bioihbjkbjnl/mcl2 huggingface dataset:
Influence of Ambient Temperature on Office Behaviors
Condition: Obesity
Study type: Interventional

Summary: 
      Based on preliminary data and previous studies, we hypothesize that the ambient temperature
      experienced by an individual influences his or her food intake. Specifically, exposure to
      temperatures above the thermoneutral zone (TNZ) will decrease consumption in young adults in
      a sedentary situation. Researchers will execute a crossover randomized control trial
      specifically testing thermal exposure and its effect on individual female's food consumption.
    

Detailed description: 
      Participants will receive and wear a t-shirt. They will have a thermal image taken of the
      inner canthus of their eye and middle finger nail bed, representing a baseline of core and
      peripheral temperatures, respectively. They will also have their metabolic rate measured via
      a canopy hood method. At their initial visit, they will be randomized to either a colder
      environment (66-68°F) or a warmer environment (77-79°F) under the artifice of monitoring
      routine office work with abnormal temperature conditions. Their knowledge of the experiment
      will be limited until the end. They will experience this temperature while filling out
      paperwork and performing basic office tasks for a 7 hour work day. At the beginning and end
      of each day they will fill out a questionnaire on their appetite and thermal comfort. After
      the first 3.5 hours, another thermal image will be taken and the participant will be
      presented with lasagna and water and directed to eat at their leisure and subsequently finish
      the office tasks over the next 3.5 hours. A thermal image will be taken and metabolic rate
      will be assessed at the end of the day. Snacks will be available throughout the day. The
      participants will return approximately 1 week later to experience the other thermal
      environment following the same protocols. The participants will then be debriefed on the
      parameters of the experiment and body measurements will be taken at the end so as to prevent
      bias of the subject by limiting their food intake. We will quantify energy intake by weighing
      remaining food and comparing to known caloric content by weight from bomb calorimetry tests.
      The infrared thermal images will determine whether the temperatures experienced were extreme
      enough to initiate a change in thermoregulation.
    

Intervention name(s): thermostat
Intervention type(s): Other
Intervention description(s): ambient temperature as modified by thermostat
Other intervention name(s): Environmental
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Health Services Research
Safety and Efficacy Adipose-Derived Stem Cell Injection Partial Thickness Rotator Cuff Tears
Condition: Rotator Cuff Tear - Partial Thickness
MeSH terms: Rotator Cuff Injuries
Study type: Interventional

Summary: 
      This is a prospective, randomized, multi-site, safety and efficacy study in subjects with
      rotator cuff injuries.

      Patients will fall into two categories: treatment group (12 subjects) and non-treatment or
      control group (six subjects). The treatment group will undergo a small liposuction procedure
      and receive rotator cuff repair treatment with an ultrasound-guided injection of 5cc
      adipose-derived stem cells (ADSCs) into the point of injury. The control group will receive a
      5cc cortisone injection into the point of injury
    

Detailed description: 
      The primary objectives of this study were to evaluate the safety of adult Adipose-Derived
      Stem Cell (ADRC) injection into partial thickness rotator cuff tears as indicated through
      adverse event rate and efficacy of pain and function through Rand short form-36 questionnaire
      and ASES Shoulder Score health questionnaires.

      The secondary objective of this study was to assess the efficacy of adult ADRC injection into
      partial thickness rotator cuff tears through MRIs pre-and post-injection for the therapeutics
      intent to treat a rotator cuff injury.

      Patients enrolled on this study received either ADRC (i.e., investigational treatment group)
      or TAU (i.e., control group). The investigational treatment group underwent a small
      liposuction procedure and received rotator cuff repair treatment with an ultrasound-guided
      injection of 5cc ADRCs into the point of injury. The control group received a 5cc cortisone
      injection. All patients, regardless of treatment, were followed up as indicated on the
      schedule of events table in the clinical study protocol.

      Two clinical trial sites (Sioux Falls, SD and Fargo ND) enrolled subjects in this study.
    

Intervention name(s): Adipose derived regenerative cells; Cortisone Injectable
Intervention type(s): Biological; Drug
Other intervention name(s): ADRCs; steroid
Intervention MeSH terms: Cortisone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Influence of Sugar on the Bioavailability of Cocoa Flavanols
Condition: Healthy
Study type: Interventional

Summary: 
      The primary propose of this study is to determine the impact of ingredients and matrices on
      flavanol absorption and metabolism.
    

Detailed description: 
      The investigators have conducted a randomized, triple-blind, cross-over study in 15 healthy
      human volunteers to investigate the absorption and metabolism of cocoa flavanols from a
      high-flavanol chocolate made with added sugar and a high-flavanol chocolate containing the
      sugar substitute maltitol; a nutrient-matched low flavanol control product was also fed. All
      products were matched for macro-nutrients, as well as for alkaloids (theobromine and
      caffeine), and were similar in taste and appearance. Both high-flavanol products contained
      ~259 mg cocoa flavanols, whilst the low-flavanol chocolate contained 48 mg of cocoa
      flavanols. On each study day, subjects were cannulated and baseline blood samples were
      collected prior to consumption of any of the test chocolates. Additional blood samples were
      collected at 1, 2 and 4 hours and plasma levels of flavanols were assessed using HPLC with
      fluorescence detection. All test products were well-tolerated by study participants.
    

Intervention name(s): Low flavanol chocolate; High-flavanol with sugar; High flavanol Maltitol
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): 48 mg of total flavanols from cocoa; high-flavanol containing 251 mg cocoa flavanols; high-flavanol containing 266 mg cocoa flavanols
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: Flavanol; cocoa; maltitol; absorption; metabolism; chocolate; food matrix; bioavailability
Role of Virtual Reality Simulators in Basic Hysteroscopy Training Competence
Condition: Hysteroscopy
Study type: Interventional

Summary: 
      Evaluation the efficacy of Virtual Reality simulator training in improving basic
      gynecological hysteroscopic skills and assess training levels in Ob/Gyn residents, as
      compared to others with previous hysteroscopic experience.
    

Detailed description: 
      Diagnostic or operative hysteroscopy is one of the most common surgical intervention in
      gynecological surgery. In recent years, it has acquired a central role in diagnosis and
      treatment of a variety of uterine pathologies like fibroids, polyps and uterine malformations
      It is also pivotal in the management of primary or secondary infertility. Biopsy specimens
      are also sampled with hysteroscopy in the diagnosis of endometrial cancer.

      In recent years, the technological advancements such as the use of small diameter (3,5mm)
      rigid hysteroscopes combined with "no touch" techniques have made hysteroscopy a commonly
      accepted procedure .

      As a minimally invasive procedure, hysteroscopy is associated with fewer complications than
      traditional open surgery However, it is challenging to gain manual dexterity in hysteroscopy
      because of the fulcrum effect and the orientation between the two-dimensional screen and the
      three-dimensional uterine cavity. Other difficulties are the diminished tactile feedback and
      limited degrees of freedom, . Lack of proficiency in hysteroscopy can compromise patient
      safety by causing uterine perforation and trauma to neighboring organs. Also, pulmonary air
      embolisms and pulmonary edema are potential life-threatening complications.

      Today it is generally accepted that the traditional apprentice-tutor model is no longer valid
      for training all skills necessary in Gynecological surgery and more specifically endoscopic
      surgery This agreement is based on the recognition that, in contrast to open surgery,
      endoscopic surgery demands surgical skills and psychomotor skills that should not necessarily
      be trained simultaneously. Increasing evidence strongly suggests that psychomotor skills must
      be trained earlier and outside the operating room, and several models have been proposed for
      this aim
    

Intervention name(s): Virtual Reality Training
Intervention type(s): Device
Intervention description(s): Training the obstetrics and Gynecologist Residents on Virtual endoscopic simulation and skills acquisition
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: the efficacy of VR simulator training in improving basic gynecological hysteroscopic skills
Masking: Single (Participant)
Primary purpose: Other
Does Balnotherapy Influence the Qualitiy of Life in SLE
Condition: SLE
Study type: Interventional

Summary: 
      The aim of this study was to investigate the effects of balneotherapy on the quality of life
      and on work productivity of SLE patients.
    

Detailed description: 
      SLE patients in remission/low disease activity of three immunology centers were included in
      this randomized, controlled, follow-up study. In addition to the standard of care (SOC)
      sixteen out of the thirty SLE patients received balneotherapy (15 times, for 30 minutes) and
      fourteen patients received the SOC only. Prevalidated survey instruments including LupusQol,
      SF36, and WPAI questionnaires were recorded.
    

Intervention name(s): balneotherapy
Intervention type(s): Other
Intervention description(s): Balneotherapy, a medical remedy, with medically and legally recognized mineral waters for therapeutic and rehabilitation purposes
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Pressure Support Ventilation Versus Neurally Adjusted Ventilatory Assist in Difficult to Wean Pediatric Patients
Condition: Distress Respiratory Syndrome; Weaning Failure
MeSH terms: Respiratory Distress Syndrome, Newborn; Respiratory Distress Syndrome
Study type: Observational

Summary: 
      This study assessed the effects of NAVA versus Pressure Support Ventilation (PSV) on
      patient-ventilator interaction in pediatric patients with difficult weaning from mechanical
      ventilation after moderate Pediatric Acute Respiratory Distress Syndrome (PARDS).
    

Detailed description: 
      12 pediatric patients, admitted in Pediatric Intensive Care Unit (PICU) with moderate PARDS
      and who failed up to 3 SBTs in less than 7 days, were enrolled in this study. These patients
      underwent three studies conditions, lasting 1 hour each: Pressure support ventilation 1,
      Neurally adjusted ventilatory assist and Pressure support ventilation 2.

      During each trial were recorded the patient tracings of flow, airway pressure and electrical
      activity of diaphragm for the patient-ventilator interaction analysis.
    

Intervention name(s): pressure support ventilation versus neurally adjusted ventilatory assist
Intervention type(s): Device
Intervention description(s): All patients underwent three mechanical ventilation modes, lasting 1 hour each: pressure support mode, neurally adjusted ventilatory assist and again pressure support ventilation
Observational model: Case-Crossover
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        during the study, all patients (older than 1 month and younger than 2 years) admitted to
        Pediatric Intensive Care Unit for moderate pediatric Acute Respiratory Distress Syndrome
        and ready for weaning from mechanical ventilation were evaluated.

        All patients who failed up to 3 SBTs taking less than 7 days, presenting at least two of
        the following signs: diaphoresis, nasal flaring, tachycardia (Heart Rate increase ≥ 40 bpm)
        cardiac arrhythmias, hypotension, apnea, PETCO2 increase > 10 mmHg, decrease of arterial pH
        < 7.32, PaO2 < 60mmHg with an FiO2 ≥ 0.40 (PaO2/FiO2 less than 150), were enrolled in the
        study.
      
Keywords: patient-ventilator interaction; pediatric acute respiratory distress syndrome; difficult weaning
The Effects of Logotherapy Based Psychosocial Support Program on Nursing Students on the Meaning of Life and Life Satisfaction
Condition: Meaning of Life and Life Satisfaction
Study type: Interventional

Summary: 
      This study is a psychosocial intervention program designed to intervene in the meaning of
      life and existential problems and life satisfaction in nursing students, especially during
      the epidemic. In the short term, it expects that students will gain awareness, especially in
      areas such as life satisfaction, anxiety, aimlessness, the meaning of life, deterioration in
      functionality, and in the long term, the individual's ultimate issues (death, loneliness,
      meaning and responsibility) and provide a perspective that can cope with the problems that
      may arise in these areas. Based on all these, it is aimed to raise awareness of the meaning
      of life and life satisfaction in nursing students, who constitute a young population, with
      the existential approach and logotherapy-based psychosocial support program.

      H1. The existential approach and logotherapy-based psychosocial support program will affect
      the experimental group's meaning and purpose of life scale scores.

      H2. The existential approach and logotherapy-based psychosocial support program will affect
      the experimental group's life satisfaction scale scores.

      H3. After the existential approach and logotherapy-based psychosocial support program, there
      will be a significant difference between the experimental and control groups' meaning and
      purpose of life scores.

      H4. After the existential approach and logotherapy-based psychosocial support program, there
      will be a significant difference between the experimental and control groups' life
      satisfaction scores.
    


Intervention name(s): The existential approach and logotherapy-based psychosocial support program
Intervention type(s): Behavioral
Intervention description(s): Existential Approach and Logotherapy Based Support Program, which raises awareness about the meaning and purpose of the individual's life, enables them to produce solutions to the sense of meaninglessness, anxiety, feeling of emptiness, and many other problems, and develops different perspectives.The content of the program is base on existential analysis and logotherapy. The program lasted for eight weeks, with the first and last session of the scale applications. Additional sessions were set for each session where the aims and objectives of the session could not achieve. A session lasting at least 50 minutes were held each week.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Greek Childhood Obesity (GRECO) Study
Condition: Overweight; Obesity; Dietary Habits; Physical Activity; Blood Pressure
MeSH terms: Obesity; Overweight; Pediatric Obesity
Study type: Observational

Summary: 
      The purpose of the GRECO study were to: a) to provide national data on overweight and obesity
      prevalence in a representative sample of primary schoolchildren aged 10-12 years old, b) to
      identify those socio-economic, demographic factors, as well as dietary and physical activity
      habits and familial characteristics that are associated with childhood and preadolescent
      overweight and obesity, c) to identify lifestyle and dietary patterns that are associated
      with elevated blood pressure levels and dietary sodium intake.
    


Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        A nationwide cross-sectional sample of 10-12 years old Greek schoolchildren
      
Keywords: Overweight; Obesity; Dietary intake; Physical activity levels; Blood pressure levels; Family perceptions
Light-induced Effects on Dental Implant Stability
Condition: Missing Teeth
MeSH terms: Tooth Loss; Anodontia
Study type: Interventional

Summary: 
      Until now, limited research has observed the stability of photo functionalized sandblasted
      acid-etched (SLA) titanium implants. The study includes a sample size of sixty otherwise
      healthy patients with implant replacement, comparing nonirradiated, irradiated UVA and UVC
      titanium implants. It was an interventional study with a sample size divided into three
      groups using simple randomization. Patients with nonirradiated dental implants make the
      control group A with UVA and UVC dental implants forming groups B and C, respectively. Before
      functional loading, implant stability was measured on days zero and eight weeks. SPSS 26.0 is
      used for data analysis. The data for implant stability quotient (ISQ) levels and
      osseointegration speed index (OSI) were presented as mean ± SD for each group. The effect of
      UVA and UVC on ISQ2 compared with the baseline ISQ was done by applying multiple simple
      regression analysis models, whereas the distinction between UVA and UVC was made through a
      t-test. p ≤ 0.05 was kept statistically significant. The implants irradiated with UVA
      significantly affected ISQ levels compared to other groups.
    


Intervention name(s): photofunctionalization
Intervention type(s): Procedure
Intervention description(s): UVA and UVC photofunctionalization of dental implants
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: dental implants
The Effect of Remifentanil-dexmedetomidine Compared With Remifentanil-midazolam on Patient's Satisfaction
Condition: Peripheral Arterial Occlusive Disease
MeSH terms: Arterial Occlusive Diseases
Study type: Interventional

Summary: 
      Percutaneous trans-arterial angioplasty(PTA) is one of the peripheral arterial occlusive
      disease(PAOD) treatment. During and after PTA, ischemia-reperfusion pain is induced so proper
      analgesia is important. ischemia-reperfusion injury is due to reactive oxygen species.
      Dexmedetomidine has analgesic, sedative and anti oxidant effect. So the investigators
      research the patient's satisfaction that are given the dexmedetomidine during PTA procedure.
    


Intervention name(s): dexmedetomidine; midazolam; remifentanil
Intervention type(s): Drug; Drug; Drug
Intervention description(s): - remifentanil will be administered to both dexmedetomidine and midazolam group as a routine part of procedure and it is no of interest of the protocol
Intervention MeSH terms: Midazolam; Dexmedetomidine; Remifentanil
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Biomarker Study for Heart Failure in Children With Single Ventricle Physiology
Condition: Tricuspid Atresia; Hypoplastic Left Heart Syndrome; Unbalanced AV Canal
MeSH terms: Heart Failure; Univentricular Heart; Hypoplastic Left Heart Syndrome; Tricuspid Atresia
Study type: Observational

Summary: 
      The purpose of this study is to determine if children with heart disease where there is only
      one pumping chamber("ventricle") have proteins (biomarkers") in the blood that can be used to
      monitor the function of their heart.
    

Detailed description: 
      We will investigate whether levels of blood proteins in children with well-functioning hearts
      with one ("single") ventricle are similar to levels of these blood proteins in children with
      two ventricles. For children with hearts with a single ventricle, we will examine blood
      proteins at various levels of heart function. To assess blood protein levels, we will collect
      small (6 mL) samples of blood. Heart function will be determined by existing clinical scoring
      systems. Enrolled patients will receive an echocardiogram, which is a dynamic ultrasound
      picture of the beating heart.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Patients presenting to the UCSF Pediatric Heart Center.
      
Biospecimen description: 
      Serum
    
Keywords: Single Ventricle; Congenital Heart Disease; Children; Fontan; Tricuspid Atresia; Hypoplastic Left Heart Syndrome; Heart Failure; Biomarkers; Single ventricle physiology such as:; unbalanced AV canal; Interested in patients both before and after Fontan Surgery