Cognitive Changes Associated With Breast Cancer Treatment
Condition: Breast Cancer; Cognitive Side Effects of Cancer Treatments; Stage I, II and III A Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Observational

Summary: 
      Patients with cancer often complain that their "mind does not seem to be clear." This can be
      due to stress, depression, anxiety, or physical problems caused by cancer or the treatments
      used to control symptoms. There are many purposes for this study; one of them is to learn
      about the effects of cancer treatments on the brain, and another is to identify useful tools
      to detect these effects. The results of this study may stimulate new research comparing
      different treatments to the current treatment so the researchers may learn how to treat
      symptoms more effectively and improve patient quality of life. We would also like to learn
      more about the effects chemotherapy may have on DNA.
    

Detailed description: 
      This is a prospective, longitudinal study to examine time-dependent neurocognitive changes in
      patients with breast cancer receiving adjuvant chemotherapy. This study will assess
      chemotherapy-induced cognitive dysfunction. The researchers will recruit patients with
      localized breast cancer undergoing adjuvant chemotherapy for the first time and will test the
      effects of chemotherapy on patients' cognitive function utilizing a standardized
      neuropsychological battery. Patients scheduled for chemotherapy will be given a battery of
      neuropsychological undergo MRI evaluation prior to beginning chemotherapy and one month
      following completion of treatment.
    

Intervention name(s): Questionnaires, MRI, Comet assay and Cell senescence; Questionnaires, MRI, Comet assay and Cell senescence; Questionnaires, MRI, Comet assay and Cell senescence
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Neuropsychological and psychological testing MRI, Comet assay and Cell senescence; Neuropsychological and psychological testing MRI, Comet assay and Cell senescence; Neuropsychological and psychological testing, MRI, Comet assay and Cell senescence
Other intervention name(s): Wide Range Achievement Test - Reading subtest (WRAT 4, 43); Phonemic Verbal Fluency (44); California Verbal Learning Test II (45); Logical Memory I and II (WMS III, 46); Brown Location Test (47); Paced Auditory Serial Addition Test (PASAT, 48); Trail Making Tests (49); The Trail Making Test (Part B); Grooved Pegboard (50); Digit Symbol (WAIS-III, 62); Continuous Performance Test (CPT, 51); Center for Epidemiological Study - Depression (CES-D, 52); Spielberger State Anxiety Inventory (STAI, 53); Fatigue Symptom Inventory (FSI, 54); Functional Assessment of Cancer Therapy-Cognition (FACT-Cog, 55); Wide Range Achievement Test -Reading subtest (WRAT 4, 43); Phonemic Verbal Fluency (44); California Verbal Learning Test II (45); Logical Memory I and II (WMS III, 46); Brown Location Test (47); Paced Auditory Serial Addition Test (PASAT, 48); Trail Making Tests (49); The Trail Making Test (Part B); Grooved Pegboard (50); Digit Symbol (WAIS-III, 62); Continuous Performance Test (CPT, 51); Center for Epidemiological Study - Depression (CES-D, 52); Spielberger State Anxiety Inventory (STAI, 53); Fatigue Symptom Inventory (FSI, 54); Functional Assessment of Cancer Therapy-Cognition (FACT-Cog, 55); Wide Range Achievement Test -Reading subtest (WRAT 4, 43); Phonemic Verbal Fluency (44); California Verbal Learning Test II (45); Logical Memory I and II (WMS III, 46); Brown Location Test (47); Paced Auditory Serial Addition Test (PASAT, 48); Trail Making Tests (49); The Trail Making Test (Part B); Grooved Pegboard (50); Digit Symbol (WAIS-III, 62); Continuous Performance Test (CPT, 51); Center for Epidemiological Study - Depression (CES-D, 52); Spielberger State Anxiety Inventory (STAI, 53); Fatigue Symptom Inventory (FSI, 54); Functional Assessment of Cancer Therapy-Cognition (FACT-Cog, 55)
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Potential subjects for the study will be identified MSKCC's clinic.

        Healthy control group participants will be recruited through advertisements and flyers
        which will be available/advertised in the community. Health control participants will also
        be recruited by asking survivors if they have a friend who might want to volunteer for the
        study.
      
Biospecimen description: 
      blood
    
Keywords: Breast Cancer; Quality of life