bioihbjkbjnl/mcl2 huggingface dataset:
Effect Of Dry Needling On Quality Of Life In Patients With Trigger Fingers
Condition: Trigger Finger Disorder
MeSH terms: Trigger Finger Disorder
Study type: Interventional

Summary: 
      This study will be conducted to investigate the effect of dry needling on quality of life in
      patients with trigger finger
    

Detailed description: 
      Trigger finger (TF) is one of the most prevalent causes of hand disability and is a common
      cause of referral to orthopedic clinics. Trigger finger is tenosynovitis of the flexor
      sheaths that typically occurs in the 4th finger and thumb as a result of repetitive use. The
      incidence of TF is 28:100,000 per year or lifetime risk of 2.6% in the general population. It
      has the highest incidence being between 52 and 62 years more in women (75%). Thumb and fourth
      digit (ring finger) are the most commonly affected fingers.

      Dry needling (DN) is a relatively new technique used by physical therapists to treat
      myofascial trigger points (MTrPs) and various pain syndromes. Dry needling is defined as a
      "skilled intervention using a thin filiform needle to penetrate the skin that stimulates
      myofascial TrPs, muscles, and connective tissue for the treatment of musculoskeletal pain
      disorders. DN has analgesic and anti-inflammatory effects, it is commonly used to relieve
      pain and reduce inflammation.
    

Intervention name(s): Dry needling; conventional treatment
Intervention type(s): Procedure; Other
Intervention description(s): Firstly the skin is cleaned with a piece of cotton immersed in alcohol. Then sterilized disposable thin, stainless steel needles (25 × 0.30 mm) will be inserted into the skin over the nodule in A1 pulley anatomic location. The duration of needling will be 1 minute. The needle will be inserted deeply at 45° to the level of metacarpophalangeal level to the nodule. The needle may be inserted into the tendon. This is confirmed by needle movement when the patient ﬂexes and extends the distal phalanx. The needle is withdrawn slowly until this motion ceases, and the needle tip is in the A1 pulley. This will be repeated 2 times per week for 5 weeks.; Finger splint is designed to stabilize and immobilize a small finger joint. A wide, flat band offers comfortable pressure distribution and control. Contoured finger splint with a comfortable, close fit. The patient will use the splint at night. Can easily be adjusted to accommodate swollen digits. Suitable for a number of finger conditions.
Therapeutic ultrasound is often used by physiotherapists to reduce pain, increase circulation and increase mobility of soft tissues. Additionally, the application of ultrasound can be helpful in the reduction of inflammation, reducing pain and the healing.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Youth Epilepsy and Successful Self-Management Intervention
Condition: Epilepsy
MeSH terms: Epilepsy
Study type: Interventional

Summary: 
      This study is designed as a pilot test of the YESS! web-based intervention for adolescents
      with epilepsy. One hundred twenty participants will be given access to the intervention for a
      period of eight weeks. The investigators are testing the feasibility and acceptability of the
      the study procedures, measures and of the intervention itself. The study also evaluats the
      potential for impact on the users.
    

Detailed description: 
      YESS! is a web-based self management program developed to enhance the motivation and skills
      of youth with epilepsy.

      This clinical trial uses a pre-test, post-test design where all consenting participants are
      given access to the intervention.
    

Intervention name(s): YESS!
Intervention type(s): Behavioral
Intervention description(s): Web based self-management education
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Efficacy of Matricariae Chamomilla L., Melissa Officinalis L. and Tyndallized Lactobacillus Acidophilus (H122) for Infantile Colics
Condition: Infantile Colics
MeSH terms: Colic
Study type: Interventional
Phase: Phase 4

Summary: 
      A multicenter prospective, randomized comparative study will be conducted in infants with
      colic, according to Rome III criteria. Enrolled infants will be assigned at random to receive
      Chamomilla L., Melissa Officinalis L. and tyndallized L. Acidophilus (H122), L reuteri DSM
      17938 (108 CFU) or simethicone. Treatment will be given to subjects for 28 days and they will
      be followed for 4 weeks. Treatment success will be assessed at the end of study period. Daily
      crying and fussing times will be recorded in a structured diary, and maternal questionnaires
      will be completed to monitor changes in infant colic symptoms and adverse events.
    

Detailed description: 
      This will be a prospective, multicentre, open label, randomized, controlled trial. All
      consecutive infants diagnosed with IC, according to Rome III criteria, will be prospectively
      enrolled in a 12 months period by 3 different Pediatric Gastroenterology units: Department of
      Translational Medical Science, Section of Pediatrics, University of Naples "Federico II";
      Institute of Pediatrics of the University of Foggia; Endoscopy and Gastroenterology Unit,
      Department of Pediatrics, University of Messina.

      After the enrollment, all children will be randomly assigned to receive Chamomilla L.,
      Melissa Officinalis L. and tyndallized L. Acidophilus (H122) (Group A), L reuteri DSM 17938
      (108 CFU) (Group B) or Simethicone (Group C). Treatment will be given to subjects for 28
      days. The study's primary outcome is defined as a reduction in the duration of average crying
      times, from baseline (day 0) to end of treatment (day 28). The secondary outcome measure is
      the number of participants who respond to treatment on days 28. Infants who experience a
      decrease in the daily average crying time of 50% from baseline will be considered as
      responders to the treatment. Parents will be instructed to complete a structured 28-day
      maternal diary, modified from Barr et al. in order to record the frequency of colic episodes
      and the daily crying and fussing time (in minutes), feeding schedule, stool frequency and
      characteristics, and any adverse events experienced (14). Follow-up visits will be conducted
      on study days 7, 14, 21 and 28 by the same study investigator. At that visit, diaries and
      unused study products will be returned.
    

Intervention name(s): Standardized extract of Chamomilla L., Melissa Officinalis L. and tyndallized L. Acidophilus (H122); Lactobacillus reuteri DSM 17938 (108 CFU); Simethicone
Intervention type(s): Dietary Supplement; Dietary Supplement; Drug
Intervention MeSH terms: Simethicone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Infantile colics
Randomized Trial Comparing Endoscopy and Surgery for Pancreatic Cyst-gastrostomy
Condition: Pancreatic Pseudocysts
MeSH terms: Pancreatic Cyst; Pancreatic Pseudocyst
Study type: Interventional

Summary: 
      Patients with pancreatitis can develop inflammatory fluid collection around the pancreas
      called pseudocysts. Pseudocysts may cause abdominal pain when they are more than 6cm in size.
      These pseudocysts can be treated (drained) by surgery or by endoscopy. Both treatment options
      are the current standard-of-care at all institutions around the World. The aim of this study
      is to identify the better of the two techniques, surgery versus endoscopy, for treatment of
      patients with pancreatic pseudocysts. This will be done by comparing a) the rates of
      pseudocyst recurrence b) quality of life of patients following treatment and c) cost
      associated with treatment, between both treatment modalities.
    

Detailed description: 
      The purpose of this study is to examine endoscopic ultrasound guided celiac plexus neurolysis
      (CPN) with analgesic therapy in patients with unresectable pancreatic cancer will decrease
      the severity of abdominal pain when compared to analgesic therapy alone. The specific primary
      aim of this study is to evaluate the efficacy of EUS-CPN + analgesic therapy (Group 1) in
      pain relief of patients with unresectable pancreatic cancer when compared with analgesic
      therapy (Group 2). The hypothesis will be tested by comparing the changes in reported pain
      severity between those who receive EUS-CPN in addition to analgesic therapy as compared to
      analgesic therapy alone.
    

Intervention name(s): Endoscopic cyst-gastrostomy; Surgical cyst-gastrostomy
Intervention type(s): Procedure; Procedure
Intervention description(s): After passing a small camera into the stomach the pseudocyst will be punctured and drained into the stomach by stent placement.; After making an incision in the abdomen the pseudocyst contents will be emptied and the pseudocyst will be sutured to the stomach.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Bioequivalence Study of Daclatasvir From Prodactariv 60 mg Film Coated Tablets (International Drug Agency for Pharmaceutical Industry (IDI), Egypt) and Clatazev 60 mg Tablets (Bristol-Myers Squibb Pharma, UK)
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      An open label randomized, single dose, two-way crossover bioequivalence study to determine
      the bioequivalence of Daclatasvir from Prodactariv 60 mg F.C.T (International Drug Agency for
      Pharmaceutical Industry (IDI), Egypt) and Clatazev 60 mg F.C.T (Bristol-Myers Squibb Pharma,
      UK) in Healthy Human Volunteers Under Fasting Condition
    

Detailed description: 
      Primary Pharmacokinetic Parameters: Cmax, AUC0→t and AUC0→∞ Secondary Pharmacokinetic
      Parameters: Ke, tmax and t1/2e. ANOVA using 5% significance level for transformed (with the
      90% confidence intervals) and untransformed data of Cmax, AUC0→t and AUC0→∞ and for
      untransformed data of Ke, tmax and t1/2e.

      The confidence intervals of logarithmically transformed Test/Reference ratios for Cmax,
      AUC0→t and AUC0→∞ to be within 80.00-125.00%.

      A comprehensive final report will be issued upon the completion of the study.
    

Intervention name(s): Prodactariv; Clatazev
Intervention type(s): Drug; Drug
Intervention description(s): 1 tablet contains 60 mg Daclatasvir; 1 tablet contains 60 mg Daclatasvir
Other intervention name(s): Daklinza; Daklinza
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Strength Training to Improve Gait in People With Multiple Sclerosis
Condition: Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Sclerosis
Study type: Interventional

Summary: 
      This study will pilot a strengthening intervention targeted to muscles found to be important
      to gait in people with multiple sclerosis (MS). Previous studies that have tried to
      strengthen leg and trunk muscles in people with MS have failed to improve walking ability
      consistently. The investigators think that is because strengthening exercises were not
      targeted to the correct muscle groups. For this study the investigators propose targeting
      muscle groups that they have found to be strong contributors to walking in a prior study.
      This is the first study to target these muscles, so the investigators propose doing a small
      trial to first evaluate the feasibility of the strength program and the outcomes. The
      investigators will measure strength and walking measures twice before and once after an
      8-week strengthening intervention in a single group of 10 people with MS who are able to walk
      independently. The results of this study will help inform future, larger trials that could
      change the way strength training is conducted in people with MS.
    


Intervention name(s): Strength exercise
Intervention type(s): Other
Intervention description(s): Strengthening exercises performed with physical therapist.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: rehabilitation; physical therapy
Multiple Ascending Dose Tolerability, Pharmacokinetic and Pharmacodynamic Study of DG3173
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This multi-ascending dose study is designed to investigate the safety, tolerability,
      pharmacokinetic and side effect profile of multiple ascending doses of DG3173, in up to 48
      healthy volunteers.
    


Intervention name(s): DG3173; DG3173+Octreotide; Octreotide; DG3173 Placebo; DG3173 Placebo+Octreotide Placebo; Octreotide+DG3173 Placebo
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Intervention MeSH terms: Octreotide
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Impact of Visceral Osteopathic Treatment on Meconium Evacuation in Preterm Infants
Condition: Meconium Ileus
MeSH terms: Meconium Ileus
Study type: Interventional
Phase: Phase 4

Summary: 
      Timing of the first and last meconium stool is critical for oral feeding tolerance and proper
      gastrointestinal function. The time until premature infants pass their first meconium ranges
      from 1 hour to 27 days (median: 43 hours). Obstruction of the gastrointestinal tract by
      tenacious, sticky meconium frequently leads to gastric residuals, a distended abdomen and
      delayed food passage Recent data support the concept that complete rapid evacuation of
      meconium plays a key role in feeding tolerance . If duration to full enteral feedings is
      extended, the probability to acquire infections due to intravenous access for parenteral
      nutrition increases and hospital stay of the infant prolongates. Previously two prospective
      trials focusing on the problem of delayed meconium evacuation in preterm with different
      therapeutic pharmacological approaches were published by our group. None of the applied
      therapies appeared to be effective or had a beneficial effect- quite the contrary one agent
      (Gastrografin) was supposed to have severe negative side effects. Therefore we were looking
      for an alternative, non-invasive, holistic solution for the problem of delayed meconium
      excretion. Osteopathic treatment with the emphasis on the relationship of the structural and
      functional integrity of the body and with its variety of therapeutic manual techniques seemed
      to be remedy. Treating the abdomen of premature infants with visceral osteopathic techniques
      might be more effective to mobilize meconium from small bowel and deep parts of the colon.
      Therefore we hypothesized that repeated visceral osteopathic treatment accelerates meconium
      evacuation in premature infants, and thereby enhances feeding tolerance in this population.
    


Intervention name(s): Osteopathic treatment
Intervention type(s): Procedure
Intervention description(s): visceral osteopathic treatment algorithm: Global listening and local listening on the abdomen Release lower ribs and thoracic diaphragm Pylorusrelaxation Release of the Duodenum and the C-Loop Small intestine diagnosis- Lifting the gut and bringing it to a stillpoint Root of mesentery diagnosis (and manipulation) Mobilisation of the ileocoecalic valve Mobilisation of colon ascendens, transversum, descendens Root of sigmoid diagnosis and manipulation
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: premature infant; visceral osteopathy; alternative medicine; meconium passage; enteral feedings; hospital stay
Venner a.p. Advance Video Laryngoscope
Condition: Intubation; Resuscitation
Study type: Interventional

Summary: 
      The purpose of this study was to compare the Venner a.p. advance video laryngoscope to Miller
      laryngoscope during resuscitation with and without chest compressions.
    

Detailed description: 
      Endotracheal intubation (ETI) is a life-saving procedure performed daily in emergency
      medicine. The European Resuscitation Council (ERC) 2010 cardiopulmonary resuscitation (CPR)
      guidelines suggest that intubators should be able to secure the airway without interrupting
      chest compression. However, ETI with uninterrupted chest compression in patients can be a
      very difficult skill to acquire.
    

Intervention name(s): VAVL; MIL
Intervention type(s): Device; Device
Intervention description(s): Videolaryngoscope; Direct laryngoscopy
Other intervention name(s): Venner a.p. advance video laryngoscope; Miller Laryngoscope
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
RP5063 in Subjects With Schizophrenia or Schizoaffective Disorder
Condition: Acute Schizophrenia; Schizoaffective Disorder
MeSH terms: Schizophrenia; Psychotic Disorders
Study type: Interventional
Phase: Phase 2

Summary: 
      The objective of this study is to evaluate the efficacy and safety of RP5063 relative to
      placebo for the treatment of schizophrenia or schizoaffective disorder.
    


Intervention name(s): RP5063; placebo; RP5063; RP5063; aripiprazole
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): daily; daily; daily; daily; daily
Intervention MeSH terms: Aripiprazole; RP5063
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
The Influence of a "Cooling Ice Spray " Application on the Time to Stability After a Forward Jump?
Condition: Healthy
Study type: Interventional

Summary: 
      The aim of this study is to investigate the influence of a brief application of cold (by
      means of Cooling Ice Spray on the lateral ankle)on the time to stabilization of healthy
      subjects.
    

Detailed description: 
      In sports are "Cooling Ice Spray" applications after an injuries one of the most common and
      popular methods used. It is very popular mainly because of its analgesic effect and easy
      application. It is assumed that such application will not affect the athletes. Nevertheless
      after an application of cold a reduced nerve conduction velocity was measured, resulting in a
      reduction in pain and a reduced transmission rate. Usually the static equilibrium or the
      perception of joint position was investigated and not the time to stability. As far as we
      have been known so far been no study that has examined the impact of a brief application of
      cooling ice spray on the time to stability after dynamic function. Therefore this study
      what's to investigate the influence of "Cooling Ice Spray" on the time to stability after a
      forward jump.
    

Intervention name(s): Cooling Ice Spray; water
Intervention type(s): Other; Other
Intervention description(s): A bursts of the "Cooling Ice Spray" over a period of 10 seconds (15 cm distance) will be applied at the dominant foot in before each test.; A bursts of the water spray (room temperature over a period of 10 seconds (15 cm distance) will be applied at the dominant foot in before each test.
Other intervention name(s): Perskindol Cool Spray; Placebo water
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Diagnostic
Keywords: Cooling ice spray; Time to stability; Jump
Study of BK1301 (DTaP Vaccine) as a Booster in Adolescents
Condition: Diphtheria; Tetanus; Pertussis
MeSH terms: Whooping Cough; Tetanus; Diphtheria; Tetany
Study type: Interventional
Phase: Phase 3

Summary: 
      This study is designed to assess the immunogenicity and safety of DTaP vaccine (BK1301) as a
      booster dose in adolescents.

      The purposes of this study are as follows:

        -  To confirm the non-inferiority of BK1301 to Adsorbed Diphtheria-Tetanus Combined Toxoid
           (DT toxoid) with respect to booster responses for anti-diphtheria toxoid (anti-D) and
           anti-tetanus toxoid (anti-T) antibodies

        -  To confirm that booster responses for anti-pertussis toxoid (anti-PT) and
           anti-Filamentous Hemagglutinin (anti-FHA) antibodies are more than 80% of participants
           received BK1301
    


Intervention name(s): Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed (DTaP vaccine, BK1301); Adsorbed Diphtheria-Tetanus Combined Toxoid (DT toxoid)
Intervention type(s): Biological; Biological
Intervention description(s): 0.5 mL, subcutaneous injection; 0.1 mL, subcutaneous injection
Other intervention name(s): TRIBIK®; DTBIK®
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Diphtheria; Tetanus; Pertussis; DTaP vaccine; Adolescents
Pediatric Epilepsy Trial in Subjects 1-24 Months
Condition: Epilepsy
MeSH terms: Epilepsy
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is being conducted to evaluate the effectiveness and safety of LAMICTAL added to
      the current therapy of pediatric patients age 1-24 months old with partial seizures. The
      medication used in this study has been approved by FDA for the adjunctive treatment of
      partial seizures in patients 2 years and older.
    


Intervention name(s): lamotrigine
Intervention type(s): Drug
Intervention MeSH terms: Lamotrigine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: partial seizures; pediatric; epilepsy
Effect of Gender and HIV Infection on Zidovudine and Lamivudine Pharmacokinetics
Condition: HIV
Study type: Interventional
Phase: Phase 4

Summary: 
      This study evaluated the blood and blood cell concentrations of zidovudine and lamivudine in
      men versus women and in those with versus without HIV infection. Additionally, markers of
      side effects were correlated with blood levels of the drugs. The hypothesis was that women
      and those with HIV would have higher drug levels, as well as markers of side effects.
    


Intervention name(s): zidovudine 300mg and lamivudine 150mg as Combivir
Intervention type(s): Drug
Intervention description(s): twice daily for 12 days in the HIV-negative group and indefinitely for their care in the HIV-positive group
Intervention MeSH terms: Lamivudine; Zidovudine; Lamivudine, zidovudine drug combination
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Pharmacokinetics; antiretroviral therapy; nucleoside analogs; mitochondrial toxicity; clinical pharmacology; cellular pharmacology; pharmacogenetics