Health Parameters in Soccer Players and Sedentary Individuals After Consuming a Synbiotic
Condition: Athlete; Sedentary Behavior
Study type: Interventional

Summary: 
      The main objective of this research was to carry out an experimental study, triple blind, on
      the possible immunophysiological effects of a nutritional supplement (Synbiotic, Gasteel
      Plus®, Heel España S.A.U.), containing a mixture of probiotic strains, such as
      Bifidobacterium lactis CBP-001010, Lactobacillus rhamnosus CNCM I-4036, Bifidobacterium
      longum ES1, as well as prebi-otic fructooligosaccharides, in both professional athletes and
      sedentary people. The effects on some inflammatory/immune (IL-1β, IL-10, and immunoglobulin
      A) and stress (epinephrine, nore-pinephrine, dopamine, serotonin, CRH, ACTH, and cortisol)
      biomarkers were evaluated, determined by flow cytometer and ELISA. The effects on metabolic
      profile and physical activity, as well as on various parameters that could affect physical
      and mental health, were also evaluated via the use of accelerometry and validated
      questionnaires.
    

Detailed description: 
      This investigation was a triple blinded, randomized, placebo-controlled pilot study designed
      to identify the possible differing effects of the synbiotic Gasteel Plus® supplementation.

      The participants were professional soccer players of the Second Division B of the Spanish
      League and sedentary students of the same sex and age range. Both study groups were randomly
      divided into two groups: a control group administered with placebo, and an experimental group
      administered with the synbiotic. Each participant was evaluated at baseline, as well as after
      the intervention which lasted one month. Only in the athletes group did the synbiotic
      intervention clearly improve objective physical activ-ity and sleep quality, as well as
      perceived general health, stress, and anxiety levels.
    

Intervention name(s): Synbiotic complement; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): On two separate days, the "baseline-tests" and "final-tests" were conducted. All participants performed a series of tests, before which they had to fast. The order and schedule (8 am) of the tests was the same for the "final-test" and the same materials and procedures were used. A period of 30 consecutive days elapsed between the base-line and final tests, during which the participants had to ingest their supplement (synbiotic).; On two separate days, the "baseline-tests" and "final-tests" were conducted. All participants performed a series of tests, before which they had to fast. The order and schedule (8 am) of the tests was the same for the "final-test" and the same materials and procedures were used. A period of 30 consecutive days elapsed between the base-line and final tests, during which the participants had to ingest their supplement (placebo).
Intervention MeSH terms: Complement System Proteins
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Supportive Care
Keywords: anxiety; immunity; inflammation; prebiotic; probiotic; sedentarism; soccer; stress; synbiotic