Effect of Consumption of Supplements and Enriched Olive Paste on Bone Metabolism Indices
Condition: Osteopenia or Osteoporosis
MeSH terms: Osteoporosis; Bone Diseases, Metabolic
Study type: Interventional

Summary: 
      It was a prospective randomized controlled trial. A sample of 115 apparently healthy
      post-menopausal women(45 -75 years of age) randomized into four groups and received
      supplements of Ca, Vitamin D and Mg with or without enriched olive paste and with or without
      Vitamin C. Changes in calciregulatory hormone were evaluated at the beginning of the study,
      at 5 and 12 months . Blood levels of vitamin D, vitamin C, Ca, Mg, the lipid profile,
      anthropometric indices and bone density were assessed at the beginning and at the end of the
      study.
    

Detailed description: 
      : It was a prospective randomized controlled trial. A sample of 115 apparently healthy
      post-menopausal women(45 -75 years of age) randomized into four groups: (I) nutritional
      intervention group(n=40) received daily 1000mg vitamin C, 500mg vitamin D3, 500mg calcium(Ca)
      and 300mg magnesium (Mg); (II) control group(n=42) received daily 500mg vitamin D3, 500mg Ca
      and 300mg Mg; (III) nutritional intervention group (n=18) received daily 150mg
      bisphosphonates, 500mg vitamin D3, 500mg Ca and 300mg Mg; and (IV) nutritional intervention
      group (n=15) received daily about 364 mg polyphenols via an innovative functional food (50g
      olive paste enriched with mountain tea extract) along with 500mg vitamin D3, 500mg Ca and
      300mg Mg. Groups I -III received supplementation for a year whereas group IV for 5 months.
      Changes in calciregulatory hormone parathormone (PTH) were evaluated at the beginning of the
      study as well as at 5 and 12 months intervals. Blood levels of vitamin D, vitamin C, Ca, Mg
      and the lipid profile were assessed at the beginning and at the end of the study.
      Anthropometric indices (weight, body fat(Kg), Body Mass Index(BMI) and bone mineral
      density(BMD) were evaluated at the beginning and at the end of the study.
    

Intervention name(s): Functional olive paste; Calciovitmag (CDCaMg); Phosporovitmag (PDCaMg); Control
Intervention type(s): Other; Other; Other; Other
Intervention description(s): Homogenised olive pastes, enriched with mountain tea, were supplied by two ac-credited Greek olive oil and olive products companies, Arcadian Taste and GAEA. The fortified olive pastes, contained 7.5 g of extra virgin olive oil, 3.75 g of salt, 3.75 g of grated oregano, 3.75 g of grated pepper, 7.5 g of grated garlic, 6.25 g of orange juice, 65 g of Kala-mon olives without seeds and 3 g of mountain tea and weighted 100 gr per portion size, as well.; Vitamin C (1000 mg), vitamin D3 (500 mg), Calcium (Ca) (500 mg ) and Magnesium (Mg) (300 mg)/day; Bisphosphonates (150 mg), vitamin D3 (500 mg), Ca (500 mg ) and Mg (300 mg)/daily; Vitamin D3 (500 mg), Calcium (500 mg) and Magnesium (300 mg)/daily
Other intervention name(s): Olive paste enriched with mountain tea; Vitamin C and D, Calcium and Magnesium; Bisphosphonates, Vitamin D, Calcium and Magnesium
Intervention MeSH terms: Calcium, Dietary; Vitamin D; Diphosphonates; Vitamins; Calcium
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Each study arm received different supplementation.
Masking: Single (Participant)
Primary purpose: Other
Keywords: postmenopausal; osteopenia; osteoporosis; supplements; functional olive paste