Exercise, Brain, Cognition, OMICs, Molecular Markers and Functionality in People at Risk of Mild Cognitive Impairment
Condition: Mild Cognitive Impairment; Alzheimer Dementia
MeSH terms: Dementia; Alzheimer Disease; Cognitive Dysfunction
Study type: Interventional

Summary: 
      This project aims to examine the effect of a 5-month period supervised exercise intervention
      on brain, cognition, OMICs, Molecular Markers and functional status in older people at risk
      of mild cognitive impairment. Secondarily, the effect of this intervention on antioxidant
      capacity, lipid metabolism and glucose, physical health (functional capacity, blood pressure,
      body composition) and mental (quality of life and depression) will be studied, as well as
      other factors risk (genetic and biological) for the development of Alzheimer. A total of 100
      people aged between 65 and 75 years old at risk of mild cognitive impairment will be randomly
      distributed in the supervised exercise intervention group (n = 50) and control group (n =
      50). The design will include a 5-month intervention with measurements at pre and post
      intervention and a third measurement (retest) after 3 months of completion. The
      multicomponent supervised exercise program will include aerobic, strength, cognitive and
      coordinative-agility-balance works, and progression will be established in different load
      parameters (frequency, volume, intensity, density). Therefore, randomized controlled studies
      are needed to know the specific effect of dose-response considering the various dimensions in
      parallel such as neuroimaging, cognitive status and OMICS. This will allow us to understand
      from a comprehensive perspective the causes and mechanisms underlying the response. This
      project will significantly increase scientific knowledge about the role of exercise on brain
      as a therapeutic measure in people at risk of mild cognitive impairment from a
      multidimensional perspective. The project will have a significant impact at social and
      economic level by transferring the study findings to social and health setting by means of
      agents and networks provided for the project.
    


Intervention name(s): Supervised Exercise Programme
Intervention type(s): Behavioral
Intervention description(s): The methodology will be multicomponent, including aerobic, strength, coordination-cognitive and balance-agility. The physical exercise sessions will be designed in such a way that they work the dimensions but being attractive and motivating for the participants. Each session will include 10 minutes of warm-up with smooth running and mobility exercises; 35-40 minutes of aerobic, strength, coordination-cognitive and balance-agility progressively developed; and 10 minutes back to calm at low intensity with stretching exercises. Nutritional intervention will not be included. For quality purposes, we will use small groups (10-15 pers). After each session participants will be asked about their subjective perception of the effort and the intensity will be controlled by heart rate monitors.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: Physical exercise; ageing; dementia; Alzheimer; magnetic resonance image; cerebral; cognition; metabolomic; older people; mild cognitive impairment