bioihbjkbjnl/mcl2 huggingface dataset:
Impact of Procalcitonin on the Management of Children Aged 1 to 36 Month Presenting With a Fever Without a Source
Condition: Procalcitonin; Fever Without Source; Bacterial Infection; Bacteremia
MeSH terms: Bacterial Infections; Bacteremia; Fever; Hyperthermia
Study type: Interventional

Summary: 
      Serious bacterial infections are often difficult to detect in children with fever without
      source. Procalcitonin is a better blood marker of infection than White blood cell count and
      possibly than C-reactive protein. This could lead to a reduction in antibiotic prescription.
      Our objective is to evaluate the impact of Procalcitonin result on antibiotic prescription in
      children 1 to 36 month old with fever without source and our hypothesis is that it will lower
      the antibiotic prescription rate
    


Intervention name(s): Procalcitonin dosage PCT-Q test (Brahms, Germany)
Intervention type(s): Other
Intervention description(s): Procalcitonin result available to the attending physician
Other intervention name(s): PCT-Q test (Brahms, Germany)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Diagnostic
Keywords: Procalcitonin; Antibiotic; Fever without source; Fever without focus; bacteremia; Urinary tract infection
Singing in Groups for Parkinson's Disease; A Pilot Study of Group Singing Therapy for PD-related Voice/Speech Impairment
Condition: Voice Quality and Voice Loudness Associated With Parkinson's Disease
MeSH terms: Parkinson Disease
Study type: Interventional

Summary: 
      This study will compare group singing to group speech therapy without singing. You may be
      eligible for this study if you have been diagnosed with PD for one year or more and you have
      a quiet voice or difficulty being understood.
    

Detailed description: 
      The National Parkinson Foundation Center of Excellence at Beth Israel Deaconess Medical
      Center is conducting a research study to test whether group singing therapy helps people with
      voice or speech disorders due to Parkinson's disease (PD). Communication problems, including
      loss of vocal loudness, affect many people with PD. While existing forms of speech therapy
      have been shown to be helpful, group singing may be a beneficial alternative to traditional
      speech therapy.

      The study will involve participating in weekly treatment sessions where subjects will receive
      training in vocal exercises from a speech-language pathologist with expertise in PD, as well
      as instructions for structured home practice. Participants will be assigned to a singing or
      non-singing group for the 12-week treatment phase of the study. Researchers will measure
      subjects' vocal function and communication-related quality of life before and several times
      after the 12-week program. All subjects and their care partners are welcome to participate in
      a singing group following the study.

      You may be eligible for this study if you have been diagnosed with PD for one year or more,
      and you have difficulty with your voice or speech such as quiet voice, or difficulty being
      understood.
    

Intervention name(s): Singing Therapy
Intervention type(s): Other
Intervention description(s): Singing therapy as a way to improve voice quality
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Parkinson's Disease, voice quality, vocal strength, voice loudness
Rate-limiting Amino Acids in Endurance-trained Athlete
Condition: Increased Metabolic Requirement; Healthy
Study type: Interventional

Summary: 
      Protein requirements in individuals who participate in endurance-based exercise training have
      been suggested to be greater than the current recommended dietary allowance (RDA).

      The biological value of protein depends on the amino acid composition. As liebig's law of the
      minimum, the protein synthesis is limited due to the lack of single rate limiting amino acid.
      In this case, the first rate limiting amino acid determines protein intakes to maximize the
      protein synthesis. Adding a small amount of rate-limiting amino acid to the diet improves the
      biological value of its protein diet.

      The indicator amino acid oxidation (IAAO) method has clarified the individual amino acid
      requirement in children, normal healthy adult and clinical populations. however, the IAAO
      method has never been utilized for determining the first rate limiting amino acid.

      Therefore, the purpose of this study is to address of IAAO method to be applied for
      determining the rate-limiting amino acid in endurance athlete.
    


Intervention name(s): Base protein; Sufficient protein; Branched chain amino acids; Essential amino acids; Non essential amino acids
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): 0.8 g/kg/d of protein provided as crystalline amino acid modeled after egg protein; 1.75 g/kg/d protein provided as crystalline amino acid modeled after egg protein.; Branched chain amino acids modeled after egg protein.; Essential amino acids modeled after egg protein.; Non essential amino acids modeled after egg protein.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
A Study to Evaluate 4DCT Controls
Condition: Wrist Ligament and Bone Disorders
MeSH terms: Bone Diseases
Study type: Interventional

Summary: 
      The purpose of this study is to use CT motion pictures (4DCT) to visualize and record how
      much space there is between certain wrist joint bones, both without any resistance and with
      light resistance to the movement, during a single scanning visit.
    


Intervention name(s): 4DCT
Intervention type(s): Device
Intervention description(s): CT imagining conceptually similar to time-lapse photography.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Evaluating Relative Bioavailability of OC-01 (Varenicline) Nasal Spray as Compared to Orally Administered Varenicline
Condition: Healthy Subjects
Study type: Interventional
Phase: Phase 1

Summary: 
      To assess the relative bioavailability of varenicline administered intranasally at its
      highest intended clinical strength compared to varenicline administered orally at its highest
      oral tablet strength.
    

Detailed description: 
      This study was a Phase 1, open-label, randomized, 2-way crossover study to evaluate the
      relative bioavailability of OC-01 (varenicline) Nasal Spray compared to varenicline
      administered orally as varenicline oral tablet. Approximately 22 healthy volunteer subjects
      between 18-65 years of age meeting all other study eligibility criteria were randomized
      (Treatment Period 1) to receive an intranasal dose of 0.12 mg OC-01 (50 µL spray of 0.06 mg
      into each nostril) or a single 1 mg oral dose of varenicline oral tablet. Both
      administrations were delivered while subject is in an overnight fasted state. Subjects then
      returned at least 14 days later (Treatment Period 2) to receive the alternate dose of
      varenicline that was delivered at Treatment Period 1. Again, this delivery was performed
      while subject was in an overnight fasted state.

      Participants who terminated early during the application period were asked to complete safety
      assessments (if the participants agree) prior to study exit. Participants who were terminated
      early from the study were not replaced.
    

Intervention name(s): Vaenicline oral tablet 1 mg, then OC-01 (varenicline solution) nasal spray 0.12 mg; OC-01 (varenicline solution) nasal spray 0.12 mg then Varenicline oral tablet 1 mg
Intervention type(s): Drug; Drug
Intervention description(s): Cross over bioavailability study; Cross over bioavailability study
Other intervention name(s): varenicline; varenicline
Intervention MeSH terms: Pharmaceutical Solutions; Varenicline
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Other
SmART Heart: Study of mHealth Apps to Reduce Cancer-Treatment Effects on the Heart
Condition: Acute Leukemia in Remission; Hematopoietic Cell Transplantation Recipient; Lymphoma
Study type: Interventional

Summary: 
      This pilot trial studies how well education and mobile health applications work in reducing
      the effects of cancer treatment on the heart in participants with blood cancers that are in
      remission. Education and mobile health applications may be effective ways to manage heart
      health and to reduce future heart disease risk in participants with blood cancers.
    

Detailed description: 
      PRIMARY OBJECTIVES:

      I. Determine the feasibility of recruiting and retaining hematologic malignancy and
      hematopoietic cell transplantation (HCT) survivors in a randomized cardiovascular (CV) risk
      reduction mobile health (mHealth) counseling intervention.

      II. Develop and refine a protocol to engage participants using an existing social medial
      platform and commercially available mHealth tools to reinforce lifestyle goals.

      OUTLINE: Participants are randomized to 1 of 2 groups.

      INTERVENTION GROUP: Participants receive individualized goal-setting and coaching in relation
      to physical activity and diet, supplemented with peer support through the study's social
      media platform, over 4 months. They also have access to mHealth apps including Fitbit and
      Healthwatch that provide feedback on physical activity and diet.

      CONTROL GROUP: Participants receive general information about physical activity and diet, and
      access to Fitbit and Healthwatch.

      After completion of study treatment, participants are followed up at 2 months and at 1 year.
    

Intervention name(s): Monitoring Device; Informational Intervention; Informational Intervention; Questionnaire Administration
Intervention type(s): Device; Other; Other; Other
Intervention description(s): Use Fitbit tracker; Receive individualized health and fitness information from clinician, supplemented with peer support through the study's social media platform; Receive general health and fitness information from clinician; Ancillary studies
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Prevention
Difference in Grades of Epiblepharon According to Positional Changes and General Anesthesia
Condition: Epiblepharon
Study type: Observational

Summary: 
      Epiblepharon is a very common condition among Asian children and is a fold of the skin and
      underlying pretarsal orbicularis muscle that overlaps the eyelid margin and pushes the lashes
      against the cornea. It is manifested by the anterior lamella overriding the posterior lamella
      which causes the lashes to brush against the cornea. Although the prevalence of epiblepharon
      is known to be high among Asians, its cause remains controversial. Several etiological
      factors may be involved in the pathogenesis of epiblepharon.

      Although epiblepharon in the lower lids lessens and disappears with age in many cases,
      surgery must be performed at an early age in severe cases in order to prevent ocular trauma
      as the vertically oriented cilia of the lashes can erode the corneal epithelium. Induced
      keratitis and astigmatism are indications for surgical intervention.

      Over our many years of surgical experience, the investigators came to realize that the
      severity of epiblepharon was reduced when patients were under general anesthesia during
      surgery. The purpose of this study was to investigate the role of the orbicularis muscle in
      the pathogenesis of lower lid epiblepharon and to analyze the differences in the severity of
      epiblepharon in the upright versus the supine position and before and after the induction of
      general anesthesia.
    


Observational model: Case-Only
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Subjects with epiblepharon which needed surgical correction
      
Keywords: Epiblepharon, general anesthesia, positional change
Open Versus Arthroscopic Release for Lateral Patellar Compression Syndrome: Comparative Study
Condition: Knee Arthroscopy
MeSH terms: Syndrome
Study type: Interventional

Summary: 
      Chronic anterior knee pain with a stable patella is often associated with overload and
      increased pressure on the lateral facet due to pathologic lateral soft-tissue restraints.
      "Lateral pressure in flexion" is a term describing the pathologic process of increasing
      contact pressure over the lateral patellar facet as knee flexion progresses. Eighty patients
      were involved in this study, and it was divided into 2 random groups; Group A (40
      patients)(odd number) were treated with open release after diagnostic arthroscopy and Group B
      (40 patients)(even number) were treated by arthroscopic release. All these patients are
      diagnosed as lateral patellar compression syndrome depending on clinical features, MRI and
      diagnostic arthroscopy. All patients were followed by Lysholm knee scaling score before
      surgery and two weeks , six weeks then 6 months after surgery.
    

Detailed description: 
      This study was done by two orthopedic surgeons working in three hospitals from March 2016 to
      April 2018, Eighty patients were involved in this study, and it was divided into 2 matched
      groups; Group A (40 patients) were treated with open release after diagnostic arthroscopy and
      Group B (40 patients) were treated by arthroscopic release. All these patients are diagnosed
      as lateral patellar compression syndrome depending on clinical features, MRI ( figure 1)and
      diagnostic arthroscopy. All patients were followed by Lysol knee scaling score before surgery
      , two weeks , six weeks then 6 months after surgery. The two groups are matched related to
      age and gender. 52 patients are females and age ranged from 21-48 years.

      Exclusion criteria are 1. Smoking 2.Patellar instability 3. D.M 4. Knee osteoarthritis 5.
      Previous knee surgery 6. Knee deformities involving Varus , valgus or recurvatum 7. Ligament
      laxity
    

Intervention name(s): open release
Intervention type(s): Procedure
Intervention description(s): Open release of lateral retinaculae
Other intervention name(s): Arthroscopic release
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Lateral patellar compression syndrome; Arthroscopic release; Open release
Sphenopalatine Ganglion Block in Septorhinoplasty
Condition: Pain, Postoperative; Rhinoplasty
MeSH terms: Pain, Postoperative
Study type: Observational

Summary: 
      Septorhinoplasty is a widely performed surgery that aims to correct both functional and
      aesthetic problems of the nose. Despite its expected clinical benefits, septorhinoplasty
      surgery causes postoperative pain, which affects the patient's functional recovery and
      satisfaction. Opioids, Non-steroidal anti-inflammatory drugs (NSAII), acetaminophen and local
      anesthetics are used in peroperative pain management in septorhinoplasty. Sphenopalatine
      ganglion block (SPGB), which has been recently described and has different application areas,
      is a regional analgesia technique that has been investigated for this purpose. Although there
      are studies on postoperative pain in septorhinoplasty surgeries, there are not enough studies
      on its effects on intraoperative pain.

      This study may have positive effects on appropriate pain management, patient comfort and
      surgical outcomes as multimodal analgesia management in septorhinoplasty surgeries, and may
      make significant contributions to evidence-based practices.
    


Intervention name(s): Sphenopalatine Ganglion Block
Intervention type(s): Procedure
Intervention description(s): For SPGB, the plastic part of the 16G angiogram is advanced transnasally into both nostrils, with the patient in the supine position and the head in 15-20° extension, until it contacts the posterior mucosa, and after contact, it is withdrawn 1 mm and 2 ml of 0.5% bupivacaine is dripped into the postnasal space within 1 minute. is applied.
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Patients who operated for septorhinoplasty
Validation of Pulse Wave Doppler Demodulation Algorithm for the Continuous, Non-invasive Measurement of Blood Flow Velocity
Condition: Focus is on Healthy Subjects
Study type: Observational

Summary: 
      The investigators hypothesize that performance of fast-Fourier transformation on the raw
      Doppler signals obtained from ascending aortic blood flow will recreate the pulse wave
      Doppler trace visualized on modern echocardiography machines, and that this will allow for
      the measurement and recording of vascular flow waveforms
    

Detailed description: 
      Currently there is no commercially available mechanism for the measurement of blood flow
      velocity waveforms non-invasively. Blood flow velocity waveforms require the use of invasive
      catheters, thus precluding clinical use. Such information would allow the researcher /
      practitioner the ability to continuously measure blood flow, pulse pressure, and the
      pulsatility index of any vascular structure accessible by ultrasound with minimal additional
      risk to the subject / patient. This data, when combined with arterial blood pressure data,
      could also be used to measure peripheral pressure volume loops as well as aortic vascular
      impedance, both of which cannot be currently measured in vivo.

      The ability to measure blood flow velocity waveforms at high temporal resolution would
      provide clinicians with new tools for hemodynamic optimization (both a novel means of
      estimating myocardial oxygen consumption [pressure volume area] as well as afterload [aortic
      vascular impedance]) and researchers with the ability to conduct hemodynamic experiments that
      were not previously possible. This work will serve as the foundation for several other
      related projects which depend on the ability to continuously record blood flow velocity
      waveforms.
    

Intervention name(s): measure ascending aortic blood flow with pulse wave Doppler
Intervention type(s): Device
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Healthy subjects 18-65
      
Keywords: Doppler
Long-term Functional Outcome of Children With Inflammatory Bowel Disease
Condition: Inflammatory Bowel Disease
MeSH terms: Intestinal Diseases; Inflammatory Bowel Diseases
Study type: Observational

Summary: 
      Inflammatory bowel diseases (IBD) are group of immune system disorders characterized by a
      chronic course with remission and relapses. Canada is one of the countries with the highest
      prevalence and incidence rates of IBD with 25% of patients present in children and
      adolescents.

      As with any chronic illness, IBD diagnosed early in life has a significant impact on the
      physical, emotional and social development of those affected. Consequently, it is logical to
      speculate that patients with IBD may not do as well in education levels or employment status
      attained compared to their peers without IBD. If this were the case, then interventions could
      begin in childhood to better prepare patients with IBD for the challenges of living with a
      chronic disease. Alternatively, if it is shown that they reach comparable social or
      employment milestones as adults compared to unaffected peers then this would be enormously
      reassuring to children and their parents.

      Properly designed studies to help in defining more appropriate interventions to these
      patients are needed.

      The proposed study includes circulating a survey to evaluate the functioning level of adult
      patients with IBD who were diagnosed during their childhood. The participants will be asked a
      series of questions regarding their highest level of educational achievement, the nature of
      their current employment, and their current marital status. The question format will parallel
      that of the Canadian Community Health Survey from which data from an age matched healthy
      adult Manitobans will be extracted and used as another control group. Responses will be
      analysed for any possible differences between these groups.
    


Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        The participant population will be comprised of adult patients who were initially diagnosed
        with IBD in childhood or adolescence (diagnosis was made < age of 18 years) and who were
        followed by the Section of Pediatric Gastroenterology at the Winnipeg Children's Hospital
        from 1974 - 2009.

        Controls: age and sex-matched control group will be generated using the Canadian Community
        Health Survey (CCHS) 2012 (16) with access through the local Research and Data Centre
        (RDC).
      
Keywords: IBD; Crohn; Colitis; Function
A Phase III Study Evaluating The Efficacy and Safety of HSK3486 for Sedation or Anesthesia
Condition: Sedation or Anesthesia
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a Phase III, randomized, double-blind, propofol-controlled, parallel-design,
      multi-center study to evaluate the efficacy and safety of HSK3486 for sedation or anesthesia
      in patients undergoing colonoscopy and gastroscopy.

      The study will enroll approximately 280 adults. The maximum study duration is anticipated to
      be up to nine months.
    


Intervention name(s): HSK3486; Propofol
Intervention type(s): Drug; Drug
Intervention description(s): HSK3486 intravenous (iv) 0.4 mg/kg for induction, and 0.2 mg/kg top-ups for maintenance.; Propofol iv 1.5 mg/kg for induction, and 0.75 mg/kg top-ups for maintenance.
Intervention MeSH terms: Propofol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Sedation anesthesia gastrointestinal endoscopy