Effect of Protein Supplementation After Bariatric Surgery
Condition: Protein Malnutrition
MeSH terms: Malnutrition; Kwashiorkor
Study type: Interventional

Summary: 
      Obese patients, who underwent bariatric surgery, are at risk to develop protein malnutrition.
      The aim of this study is to evaluate the influence of postoperative protein supplementation
      on weight reduction, body composition and protein status.
    

Detailed description: 
      Bariatric surgery has become a major treatment option for severe obesity in adults. It has
      proven its efficiency regarding weight loss and its benefits concerning the improvement or
      even remission of obesity related comorbidities. Additionally, bariatric surgery procedures
      can be performed laparoscopically, which decreases the complication rate and reduces
      postoperative pains. Despite the advantages of bariatric surgery, attention needs to be paid
      to the possible risks following the surgical treatment. Postoperative risks often concern the
      nutritional status. It has been shown that, beside different micronutrient deficiencies,
      bariatric surgery also leads to an increased risk of developing protein malnutrition.
      Discussed reasons for this are the malabsorption of nutrients and the restricted food intake
      after surgery, which may lead to reduced protein consumption. Postoperative occurrence of
      vomiting or different food intolerances may support this effect. Accordingly, if an
      inadequate supply persists, a protein deficit will occur and this, in turn, may lead to an
      undesirable reduction in muscle mass and plasma protein levels. Based on this background,
      numerous studies indicate an increased incidence of protein malnutrition after bariatric
      surgery by detecting a decrease in levels of albumin and prealbumin, a significant reduction
      in lean body mass, as well as an inadequate protein intake after surgical treatment.

      Dietary proteins have shown to play an important role in body weight regulation. There is
      evidence that a protein-rich diet is supposed to facilitate weight loss, to support
      successful weight maintenance, to attain satiety and to preserve lean body mass. Therefore,
      the use of protein supplements after bariatric surgery may minimize the risk for developing
      protein malnutrition and hence optimize the postoperative care.

      The primary aim of this randomized, placebo-controlled, double blind pilot study was to
      evaluate the influence of postoperative protein supplementation on body weight reduction,
      body composition and protein status.
    

Intervention name(s): Resource Instant Protein 88; Resource Maltodextrin
Intervention type(s): Drug; Drug
Intervention description(s): Protein product: Resource Instant Protein 88, Nestlé Health Nutrition; postoperative intake of 30 - 35 g powder per day over 6 months.; Placebo product (Resource Maltodextrin, Nestlé Health Nutrition). Postoperative intake of 30 - 35 g powder per day over 6 months.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Supportive Care
Keywords: Bariatric surgery; Protein malnutrition; Protein supplementation; Body composition; Body fat mass; Protein intake