Prospective Cross-sectional Evaluation of Penile Helicine Circulation in Veno-occlusive Erectile Dysfunction
Condition: Erectile Dysfunction Due to Arterial Disease
MeSH terms: Erectile Dysfunction
Study type: Observational

Summary: 
      Background: The aim of this study is to evaluate the usefulness of Power Doppler in order to
      improve the diagnostic work up of veno-occlusive erectile dysfunction patients.

      Materials and Methods: Two hundred and two patients affected by erectile dysfunction, mean
      IIEF 5 = 13.5 (12-17) for at least 6 months, were enrolled in a prospective cross-sectional
      study. All patients underwent Dynamic Power Doppler after intracevernous injection of
      vasoactive drugs. Poor responders patients subsequently underwent to cavernosometry to get a
      full assessment of the vascular framework.
    

Detailed description: 
      Veno-occlusive continence is linked both to the integrity of neurological, vascular, and
      endocrine structures and to the fibro-elastic characteristics of the cavernous tissue. In
      most subjects with Erectile Dysfunction (ED), the erectile tissue presents histological
      alterations such as the reduction of smooth muscle cells and the increased deposition of
      connective tissue. A hypothesis describes these changes as promotors for the onset of
      veno-occlusive dysfunction (VOD).

      Dynamic cavernosometry, supplemented by contrast cavernosography, still represents the gold
      standard for the diagnosis of VOD allowing the visualization of the competent venous
      districts. These investigations, which had moderate popularity in the 1980s and underwent
      several variations in the methodology of execution, are rarely used today due to their
      invasiveness, the need for dedicated instruments and the scarce success of commonly adopted
      surgical treatments (vein ligation surgery).

      The recent introduction of endovascular techniques sheds new light on the correct
      classification of vascular ED, especially in those patients with a sub-optimal response to
      the use of drug therapy as an alternative to prosthetic surgery.

      Advances in imaging techniques, including Power Doppler (PD) ultrasonography, allow an
      accurate and complete study of penile circulation including the study of low-flow vessels.

      The introduction of PD, during the penile duplex ultrasound routinely performed, had
      additionally permitted the extension of the field of the study into the arteriolar
      circulation of the corpora cavernosa, making possible the assessment of the vessels with a
      "low speed flow", like the helicine arteries, which escape the standard Doppler Pulsated
      evaluation; especially during the phases of the penile tumescence and partial rigidity,
      phases 1-2, according to Erection Hardness Score .

      From an anatomical and vascular point of view, the helicine arteries usually describe an
      acute angle with the cavernous artery, delineating a Cavernous Terminal Unit (CTU).

      The dynamic penile echo-color-doppler ultrasound can evaluate the correct assessment of the
      CTU, by applying the PD function. In fact, the PD module, with calibration of the pulse
      repetition frequency (PRF) of the transducer at 700 HZ applied to the cavernous arteries in
      the dynamic phase, allows the study of the ramifications of the arteries up to the 3rd order
      and their inclination in relation to the main trunk, expression or not of the integrity of
      the CTU. In this contest, PD applied to dynamic penile duplex ultrasound, has established
      itself as a method potentially suitable in the assessment of patients with VOD.
    

Intervention name(s): Ultrasound and doppler
Intervention type(s): Diagnostic Test
Intervention description(s): Penile echocolour doppler ultrasound
Observational model: Case-Crossover
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Male patients affected by erectile dysfunction for at least 6 months