bioihbjkbjnl/mcl2 huggingface dataset:
Platelet-rich Plasma in the Treatment of Intractable Postherpetic Neuralgia
Condition: PHN - Post-Herpetic Neuritis
MeSH terms: Neuralgia; Neuritis; Neuralgia, Postherpetic
Study type: Interventional
Phase: Phase 1

Summary: 
      used ultrasound-guided platelet rich plasma nerve block to treat Intractable Postherpetic
      Neuralgia.
    

Detailed description: 
      Postherpetic neuralgia (PHN) is a kind of pain caused by varicella zoster virus invading the
      human body and infecting the corresponding ganglia. The affected ganglia are inflamed or even
      necrotic, affecting the nerve endings, the dorsal horn of the spinal cord and the sensory
      nerve tissues below, and the course of the disease is more than one month or more. Most
      patients can avoid PHN by timely and effective treatment in the acute herpes zoster period.
      However, some patients with intractable postherpetic neuralgia fail to receive timely and
      effective pain control treatment in the early stage of the disease, and the current commonly
      used clinical treatment methods often fail to achieve effective treatment results. Such
      patients often have a long course of disease, which can last for three to five years or even
      longer, Nerve damage is also more serious. Long term pain has seriously affected the quality
      of life of such patients. Therefore, how to quickly and effectively control pain has become
      the diagnosis and treatment goal of such patients with intractable post herpetic neuralgia.
      Platelet rich plasma (PRP) was widely used in muscle and bone repair due to its function of
      promoting tissue repair in the early stage. Recently, it was found that PrP can also promote
      nerve repair. Therefore, in order to further explore the therapeutic effect of PRP on
      refractory PHN patients, our department used ultrasound-guided platelet rich plasma nerve
      block to treat Intractable PHN.
    

Intervention name(s): ultrasound-guided platelet rich plasma nerve block
Intervention type(s): Biological
Intervention description(s): selected persons are treated by ultrasound-guided platelet rich plasma nerve block and the regular medicine
Intervention model: Single Group Assignment
Intervention model description: patients with Intractable Postherpetic Neuralgia
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: platelet-rich plasma; Intractable postherpetic neuralgia
Free Fatty Acid Induced Insulin Resistance
Condition: Insulin Resistance
MeSH terms: Insulin Resistance
Study type: Observational

Summary: 
      This study aims to explore time-dependent effects of lipid infusion an intramyocellular lipid
      metabolites and the induction of impaired insulin signaling.
    

Detailed description: 
      Increased availability of free fatty acids impairs glucose disposal in young healthy humans.
      Patients with type 2 diabetes have reduced whole body glucose disposal, increased ectopic
      lipid deposition in skeletal muscle and the liver and impaired mitochondrial function. Recent
      studies suggest that lipid metabolites such as diacylglycerol (DAG), ceramides and long-chain
      acyl-coA represent the active mediators inducing insulin resistance. Possible targets are
      DAG-sensitive Proteinkinase C (PKC θ, PKC ε) which inhibit the insulin signaling cascade and
      ceramides which interfere with the insulin signaling cascade at Proteinkinase B/AKT. Prior
      studies raised controvesial evidence, thus, it is yet unclear, whether DAG or ceramides are
      the primary agents inducig lipid-induced insulin resistance. Therefore, the current study
      aims to explore the time course of the appearance of intramyocellular lipid compunds during
      lipid infusion in parallel assessing markers of impaired insulin action.
    

Intervention name(s): Lipovenös lipid infusion
Intervention type(s): Dietary Supplement
Intervention description(s): Lipid enriched infusions will be applied for 2-6 hours.
Other intervention name(s): soy oil
Observational model: Other
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Healthy, lean non-diabetic humans
      
Biospecimen description: 
      muscle biopsies
    
Keywords: FFA; insulin resistance; mitochondria
LEO 29102 Single and Multiple Dose Study by Dermal Application
Condition: Atopic Dermatitis
MeSH terms: Dermatitis
Study type: Interventional
Phase: Phase 1

Summary: 
      The principal aim of this study is to obtain safety, tolerability and pharmacokinetic data
      when LEO 29102 is administered cutaneously as single and multiple doses to healthy male
      subjects.

      The study is divided into one single dose part followed by a multiple dose part.
    


Intervention name(s): LEO 29102
Intervention type(s): Drug
Intervention description(s): First-in-man. Healthy volunteers
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Metatarsophalangeal Joint Sprain Kinesiotaping
Condition: Turf Toe; Metatarsophalangeal (Joint) Sprain
MeSH terms: Sprains and Strains; Foot Injuries
Study type: Interventional

Summary: 
      kinesio taping would reduce pain, improve gait performance, and enhance the functional
      capacity of turf toe patients undergoing physical therapy
    

Detailed description: 
      Health practitioners have recently become interested in using kinesiology taping in clinical
      practice as an alternative to traditional taping and bracing procedures for treating a
      variety of diseases, including sprain of metatarsophalangeal joint of the big toe. Patients
      with turf toe can benefit from kinesiology tape because it offers therapeutic support and
      stability while preserving a normal range of motion.
    

Intervention name(s): Traditional physical therapy program; Kinsio taping; placebo Kinsio taping
Intervention type(s): Other; Other; Other
Intervention description(s): 60-minutes exercise program, three times a week on alternate days for 12 successive weeks; One full strip of kinesiology taping tape and one half-length strip were needed for the kinesiology taping application; One full strip of kinesiology taping tape and one half-length strip were needed for the placebo kinesiology taping application
Other intervention name(s): exercise program; kinesiology taping; placebo kinesiology taping
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: turf toe; Metatarsophalangeal Sprain; functional ability; gait parameters; kinesiology taping
A Two-Period Open-label Trial Evaluating Efficacy and Safety of Dasiglucagon in Children With Congenital Hyperinsulinism
Condition: Congenital Hyperinsulinism
MeSH terms: Congenital Hyperinsulinism; Nesidioblastosis; Hyperinsulinism
Study type: Interventional
Phase: Phase 3

Summary: 
      The objective of the trial is to evaluate the efficacy and safety of dasiglucagon
      administered as a subcutaneous (SC) infusion in reducing hypoglycemia in children with CHI.
    


Intervention name(s): Dasiglucagon; Standard of Care
Intervention type(s): Drug; Other
Intervention description(s): Glucagon analog; Standard of care according to site and/or country
Other intervention name(s): ZP4207
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Disappearance of Graves' Orbitopathy
Condition: Thyroid Eye Disease
MeSH terms: Eye Diseases; Graves Ophthalmopathy
Study type: Observational

Summary: 
      There is a general belief among physicians involved with Graves' orbitopathy (GO) that this
      syndrome is somehow "chronic", namely that the patient's eyes do not return the way they were
      before GO appeared.

      The general impression that comes from the available studies is that the eyes of GO patients
      do not return to normal even after a very long time since the disease appearance under the
      physician's point of view, although a discrete proportion of patients feel so. However, no
      studies are available in which the issue was examined with both objective criteria and
      self-assessment.

      The present study design was to investigated the disappearance of GO, regardless to
      treatment, in all consecutive patients with a history of GO of at least 10 years who came for
      a follow-up visit to our GO clinic over a period of 5 years.
    


Intervention name(s): Ophthalmological evaluation; Questionnaire
Intervention type(s): Diagnostic Test; Diagnostic Test
Intervention description(s): exophthalmometry, evaluation of the Clinical Activity Score (CAS), assessment of diplopia, measurement of visual acuity, assessment of the corneal status; examination of the fundi; Patients were asked to fill a questionnaire on self-perception related to GO with the following questions: i) are your eyes identical to the way they were before GO appeared?; ii) are your eyes normal? iii) do you have any limitations in daily activities related to your eyes?; iv) do you have any limitations in social life related to your eyes?
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Consecutive patients with GO
Physiotherapy Versus Use of a New Ankle Trainer Device After Ankle Fracture Operation.
Condition: Ankle Fracture - Lateral Malleolus; Post-Op Complication
MeSH terms: Postoperative Complications; Fractures, Bone; Ankle Fractures
Study type: Interventional

Summary: 
      The study will compare the functions outcomes between two different rehabilitation protocol
      after operated weber b ankle fractures
    

Detailed description: 
      Patients that are operated for weber b ankle fractures will after the surgery be randomized
      into two different post operative rehabilitation protocols. One group will receive
      conventional physiotherapy with stretching of the ankle with a non-elastic band, while the
      other group will use a new spring-loaded ankle trainer. The rehabilitation will continue for
      3 weeks. Patients will be evaluated with the Olerud Molander ankle score and visual analog
      scale for pain at 3, 6, 12 and 52 weeks follow-up. Length of hospitalization and all adverse
      events will be registered. Ankle range of motion will be registered at 6, 12 and 52 weeks
    

Intervention name(s): Ankle trainer device; Conventional physiotherapy
Intervention type(s): Device; Other
Intervention description(s): The ankle trainer provides passive stretch in dorsal flexion of the ankle as well as active plantar flexion.; The patients were instructed in stretching exercises using a non-elastic band
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: ankle fracture; rehabilitation
Characterization of Adalimumab Concentrations in Pediatric Patients With Inflammatory Rheumatic Disease With and Without Methotrexate
Condition: Rheumatic Diseases
MeSH terms: Rheumatic Diseases; Collagen Diseases
Study type: Observational

Summary: 
      This study is to assess standardized Adalimumab (ADA) concentrations in Pediatric
      inflammatory rheumatic diseases (PiRD) patients treated with ADA for ≥ 12 weeks with and
      without concomitant methotrexate (MTX) therapy and to assess peak and trough ADA
      concentrations in ADA naïve patients after first ADA administration with and without MTX
      (pre-phase).
    


Intervention name(s): pharmacokinetics (PK) measurement
Intervention type(s): Other
Intervention description(s): two ADA-PK samples will be collected during routine rheumatology visits in case of medical indicated blood draw (1 trough PK sample and 1 random PK sample per subject)
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        PiRD patients treated with ADA for medical reasons at the University Children's Hospital
        Basel/ Switzerland and at the University Children's Hospital of Tuebingen/ Germany
      
Keywords: pharmacokinetics; pharmacodynamics; Adalimumab; methotrexate; drug-drug interaction; trough ADA concentration; peak ADA concentration; Pediatric inflammatory rheumatic diseases
The Clinical Safety of Alcoholic Extract Sahastara Remedy of Extract Capsule in Healthy Volunteers
Condition: Osteoarthritis
MeSH terms: Osteoarthritis
Study type: Interventional
Phase: Phase 1

Summary: 
      The clinical safety of Sahastara remedy alcoholic extract in healthy volunteers.
      Investigators will investigate safety of 100 and 200 mg of Sahastara remedy extract capsule
      in healthy volunteers. This is Clinical trial Phase I.
    

Detailed description: 
      The sahastara remedy (SHT) is a Thai traditional medicine that is use to relieve pain of
      musculoskeletal problem. There is study shown that SHT extract was not found acute and
      chronic toxicity in rat. However, there is no study regarding safety in human. Thus, this
      study is a clinical trial Phase I that investigate clinical safety of SHT alcoholic extract
      in healthy volunteers. The clinical safety will monitor for 28 days in continuously use of
      100 and 200 mg SHT extraction 3 time a day and after stop intervention for 14 days.
    

Intervention name(s): Sahastara remedy alcoholic extract
Intervention type(s): Drug
Intervention description(s): comparison of different dose of drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Pharmacokinetics and Optimal Dose of Ertapenem in Hemodialysis Patients
Condition: End Stage Renal Disease
MeSH terms: Kidney Failure, Chronic
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine the amount of ertapenem in the blood over time
      between hemodialysis session.
    

Detailed description: 
      After a hemodialysis session, subject will be administered ertapenem and the amount of
      ertapenem in the blood will be measured at seven time periods before the initiation of the
      next hemodialysis session.
    

Intervention name(s): Ertapenem
Intervention type(s): Drug
Intervention description(s): Subjects are hemodialysis patients who are admitted to Oakwood Hospital - Dearborn
Other intervention name(s): Invanz
Intervention MeSH terms: Ertapenem
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: ertapenem; pharmacokinetic; pharmacodynamics; hemodialysis; requires hemodialysis three times a week
Treatment of Chronic Deep Vein Thrombosis (DVT) and Post-Thrombotic Syndrome (PTS) With the EkoSonic® Endovascular System
Condition: Deep Vein Thrombosis; Post-thrombotic Syndrome
MeSH terms: Thrombosis; Venous Thrombosis; Postthrombotic Syndrome; Postphlebitic Syndrome; Syndrome
Study type: Interventional
Phase: Phase 4

Summary: 
      To evaluate the efficacy of ultrasound accelerated thrombolysis using the EkoSonic®
      Endovascular System with standard infusion of thrombolytic drug for post-thrombotic syndrome
      from chronic venous occlusion.
    

Detailed description: 
      The study is designed to evaluate the safety and efficacy of ultrasound accelerated
      thrombolysis using the EkoSonic® Endovascular System with standard infusion of a thrombolytic
      drug for PTS and chronic DVT. Clinical effectiveness will be evaluated using a standard
      measure of severity of post-thrombotic syndrome over a year.
    

Intervention name(s): EkoSonic® Endovascular System; Alteplase
Intervention type(s): Device; Biological
Intervention description(s): Recombinant tissue plasminogen activator
Intervention MeSH terms: Tissue Plasminogen Activator
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: deep vein thrombosis; post-thrombotic syndrome; chronic deep vein thrombosis
Pilot Study of Free From Falls Program in Multiple Sclerosis
Condition: Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Sclerosis
Study type: Interventional

Summary: 
      This pilot study will compare how often people with multiple sclerosis (MS) fall before
      participating in the Free From Falls (FFF) educational program, during the program, and for 8
      weeks after the program. The protocol will also evaluate the accuracy, efficiency and
      convenience of an email survey to count how often people fall.
    

Detailed description: 
      This pilot study will recruit people with MS who report falling at least twice in the
      previous 2 months to participate in the FFF program. All subjects will record their falls and
      injurious falls on a daily basis for at least 3 weeks before the program, during the program
      and for 8 weeks after the program. The program will consist of a weekly 2 hour session. One
      hour of the session will be educational and one hour of the program will involve exercise.
      The outcome of this study will be change in fall rate between the periods before, during and
      after the program.
    

Intervention name(s): Educational intervention
Intervention type(s): Behavioral
Intervention description(s): This is an 8-week comprehensive fall prevention exercise and education program, with one 2-hour session each week, for people with MS, adapted from a similar program for older adults.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Accidental falls; Multiple Sclerosis; Education; Exercise; Postural balance
Obstructive Sleep Apnoea and Adipose Tissue Dysfunction
Condition: Obstructive Sleep Apnoea; Obesity; Hypoxia
MeSH terms: Apnea; Sleep Apnea Syndromes; Sleep Apnea, Obstructive; Hypoxia
Study type: Observational

Summary: 
      Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of
      cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea.
      Reduced adipose tissue oxygen availability has been described in obesity and may also be a
      mechanism in obstructive sleep apnoea. Hypoxia induces inflammation and fibrosis in adipose
      tissue which are factors contributing to cardiovascular risk. The investigators hypothesize
      that adipose tissue's oxygen uptake is reduced in subjects with obstructive sleep apnoea by
      comparing in vivo AT oxygenation and blood flow in tissue of control subjects.
    

Detailed description: 
      Assessment includes a adipose tissue biopsy and measurement of oxygenation and blood flow by
      a Clarke type electrodes and non-invasive Doppler techniques.
    

Intervention name(s): Continuous positive airway pressure devices
Intervention type(s): Device
Intervention description(s): overnight use of CPAP device
Other intervention name(s): CPAP
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Subjects with newly diagnosed obstructive sleep apnoea and controls
      
Biospecimen description: 
      adipose tissue and blood samples
    
Keywords: obesity; hypoxia; adipose tissue
Lornoxicam With Low Dose Ketamine Versus Pethidine to Control Pain of Acute Renal Colic
Condition: Renal Colic
MeSH terms: Colic; Renal Colic
Study type: Interventional

Summary: 
      Patients with acute renal colic divided into 2 groups. Group L administered ornoxicam and
      Group P administered pethidine and VAS was recorded for both groups.
    

Detailed description: 
      Prospective, randomized, double blind clinical study including 120 patients with acute renal
      pain admitted in emergency department. They were randomly assigned to one of two groups using
      a computer-generated table. Group L received lornoxicam 8 mg IV plus 0.15 mg.kg-1 ketamine
      and Group P received pethidine 50 mg IV. Parameters were observed at baseline and after 0,
      15, 30, 45 and 1 hour of drug treatment. The efficacy of the drug was measured by observing:
      patient rated pain, time to pain relief, rate of pain recurrence, the need for rescue
      analgesia, adverse events and functional status.
    

Intervention name(s): Lornoxicam and mepridine
Intervention type(s): Drug
Intervention description(s): compare the effect of each to control pain
Intervention MeSH terms: Lornoxicam
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: Renal pain; lornoxicam; pethidine; emergency room; ketamine
Dose-comparison Study of Prednisone in Heart Failure
Condition: Heart Failure
MeSH terms: Heart Failure
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to examine the efficacy of three doses of prednisone, a
      glucocorticoid, in treatment of patients with symptomatic heart failure.
    

Detailed description: 
      Heart failure is a leading cause of cardiovascular morbidity and mortality in the world. Most
      patients with acute symptomatic heart failure are admitted with fluid overload. Intravenous
      loop diuretics are an essential component of current treatment in such patients. Newly
      emerging evidence showed that glucocorticoids could potentiate natriuretic peptides' action
      by upregulating the expression natriuretic peptide receptor A (NPR-A) in the kidney, and
      produce a potent diuresis. Therefore, the investigators designed this nonblinded, randomized
      dose comparison study to compare the efficacy of prednisone at 15, 30 and 60 mg/day in
      patients with in symptomatic heart failure.
    

Intervention name(s): prednisone; prednisone; prednisone
Intervention type(s): Drug; Drug; Drug
Intervention description(s): The patients with symptomatic heart failure are treated with prednisone at dose of 15 mg/day.; The patients with symptomatic heart failure are treated with prednisone at dose of 30 mg/day; The patients with symptomatic heart failure are treated with prednisone at dose of 60 mg/day
Intervention MeSH terms: Prednisone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: heart failure; diuresis; prednisone
Exploratory Study to Investigate Efficacy of LAS41004 in a Psoriasis Plaque Test
Condition: Psoriasis
MeSH terms: Psoriasis
Study type: Interventional
Phase: Phase 2

Summary: 
      The aim of the exploratory study is to compare the dose-related efficacy of LAS41004 in a
      Psoriasis Plaque Test (PPT).
    


Intervention name(s): LAS41004; reference
Intervention type(s): Drug; Drug
Intervention description(s): once daily, topical, 100 microgram; once daily, 100 microgram
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: PPT, topical, psoriasis