BFR in Overweight Sedentary Subjects
Condition: Overweight
MeSH terms: Overweight
Study type: Interventional

Summary: 
      This project should allow the investigators to observe the effects of low load training under
      partial vascular occlusion (BFR) in comparison with resistance training at low load without
      partial vascular occlusion in sedentary people overweight on parameters : decrease in fat
      mass; increase in muscle mass 79; muscle strength; decrease in the energy cost of walking;
      increase in preferred walking speed; improvement in walking pattern in patients overweight.
      Training under partial vascular occlusion should facilitate physical activity in overweight
      people as it can be just as effective as a "classic" type training with heavy loads. Thus,
      this device could allow people for who wear heavy loads can present an obstacle to physical
      activity to feel more involved in the physical activity programs offered in medical or sports
      centers.
    

Detailed description: 
      The main objective of this study is to observe the effects of low load training under
      vascular occlusion (BFR) compared with low load resistance training without vascular
      occlusion in overweight sedentary people on parameters such as: decrease in fat mass; lower
      blood sugar levels as well as lower blood triglycerides and cholesterol levels; increased
      muscle mass; muscle strength; the reduction of the energy cost of walking; increasing the
      preferred walking speed; improving the walking pattern in overweight patients.

      3.2 Primary and secondary endpoints

      The first hypothesis is that the BFR drive will be effective in improving walking economy
      (thus reducing the energy cost of walking) and increasing the preferred walking speed, by
      improving walking patterns.

      The second hypothesis is that BFR training makes it possible to modify the body composition
      in a slight way and to promote the gain of muscle strength in overweight individuals who do
      not practice physical activity beforehand. In addition, blood tests will show a decrease in
      blood sugar, blood triglyceride levels and cholesterol.

      3.3 Study design

      This single-center project aims to test the effects of low-load training under partial
      vascular occlusion (BFR) compared to low-load resistance training without vascular occlusion
      in overweight sedentary people. The main expected effects are a decrease in fat mass, an
      increase in muscle mass and strength, a decrease in the energy cost of walking as well as an
      increase in preferential walking speed. This project is part of a continuity of research in a
      public health context in order to propose adapted and effective physical activity programs
      for an overweight population unable to train with heavy loads.
    

Intervention name(s): Exercise Intervention
Intervention type(s): Other
Intervention description(s): Training with light load with blood flow restriction (BFR)
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The procedure will consist of 6 weeks of training with or without partial vascular occlusion (depending on group A or group B) at the rate of 3 sessions per week (for a total of 18 training sessions).
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: blood flow restriction