bioihbjkbjnl/mcl2 huggingface dataset:
Arterial Spin Labeling (ASL) MRI for Cognitive Decline
Condition: Mild Cognitive Impairment; Alzheimer's Disease
MeSH terms: Alzheimer Disease; Cognitive Dysfunction
Study type: Observational

Summary: 
      The purpose of this study is to determine the value of Arterial Spin Labeling (ASL) MRI, a
      measure of blood flow to the brain, in Mild Cognitive Impairment (MCI) and compare it to
      existing measures. In particular, the investigators will compare ASL MRI to Positron Emission
      Tomography (PET/CT), which measures brain metabolism reflecting how well cells in a patient's
      brain are functioning. In addition, the investigators will assess the relationship of these
      measures to specific protein levels associated with Alzheimer's Disease in the patient's
      cerebrospinal fluid (the fluid that surrounds the brain and spinal cord) obtained by lumbar
      puncture. By comparing the information that is available from these procedures to the
      patient's performance on cognitive tests, the investigators hope to learn which procedures
      most accurately reflect and assist in determination of the potential causes of cognitive
      difficulties that arise with MCI, and thus, which are most useful in the clinical setting. In
      particular, PET scans have been found to be very useful in diagnosis of MCI and Alzheimer's
      Disease, but the investigators want to find out if they can get the same, or better,
      information from an ASL MRI scan, which is less expensive and easier to acquire.
    


Intervention name(s): FDG-PET; ASL-MRI; Lumbar Puncture
Intervention type(s): Drug; Other; Procedure
Intervention description(s): Diagnostic: FDG-PET imaging to examine neuronal health; Arterial-Spin Labeled MRI to examine cerebral blood flow; Lumbar puncture to acquire a small amount of cerebrospinal fluid for protein level analyses. Note that this will not be required in all participants.
Other intervention name(s): fluorodeoxyglucose; Arterial Spin Labeling; Spinal Tap
Intervention MeSH terms: Fluorodeoxyglucose F18
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        This project will focus on a population enriched in individuals with incipient AD (i.e.
        MCI). These subjects, as well as age-matched controls, will be recruited from the
        Alzheimer's Disease Center at the University of Pennsylania.
      
Biospecimen description: 
      cerebrospinal fluid
The Use of Fractional Ablative CO2 Laser vs Control on Acute Traumatic Injuries to Prevent Scar Formation
Condition: Scar; Trauma Injury; Burns; Wound Heal; Early Medical Intervention; Laser Therapy
MeSH terms: Wounds and Injuries
Study type: Interventional

Summary: 
      Surgical standard for treating traumatic burn injury scarring is to wait one year following
      the initial assault prior to beginning treatment. This study investigates the use of
      fractional ablative CO2 laser when begun within 3 months of a traumatic burn injury and it's
      impact on scar formation compared to the control. We hypothesized that early intervention
      would substantially mitigate the formation of scar tissue and help restore more normal
      appearing skin.
    


Intervention name(s): Fractional ablative CO2 laser
Intervention type(s): Device
Intervention description(s): Three treatments with a fractional ablative CO2 laser 8 weeks apart
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Each subject possessed extensive burn wounds. Wounds on each subject were divided into treatment arms of intervention with fractional ablative CO2 laser and control.
Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: early laser intervention; scar prevention; laser resurfacing; wound healing
Use of Recombinant Adenovirus Therapy to Treat Localized Prostate Cancer
Condition: Localized Prostate Cancer
MeSH terms: Prostatic Neoplasms
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The purpose of this study is to evaluate the safety and effectiveness of AD5-SGE-REIC/Dkk-3
      in patients with localized prostate cancer.
    

Detailed description: 
      This is a phase 1/2a clinical trial in subjects who are diagnosed with prostate cancer to
      evaluate the effectiveness of Ad5-SGE-REIC/Dkk-3 in the treatment of localized prostate
      cancer.

      Subjects enrolled will be diagnosed with localized prostate cancer (clinical stage T1/T2)
      having a Gleason score of 6 to 7 (3+4 or 4+3). Subjects will receive up to four (4)
      transrectal ultrasound (TRUS)-guided IT treatments with Ad5-SGE-REIC/Dkk-3 into the prostate
      approximately 6-weeks apart. Each treatment cycle will be performed using a minimum of three
      track injections through the prostrate using a total of 3 mL volume. Approximately 2 mL of
      the total volume will be injected into the most dense areas of cancer based on biopsy and MRI
      mapping (fusion biopsy) and 1 mL total volume will be injected into the opposite lobe of the
      prostate or other areas to ensure complete saturation of the prostate over multiple
      injections.

      Subjects who, in the opinion of the investigator, are progressing at any time after the
      second injection of Ad5-SGE-REIC/Dkk-3 may be discontinued and will be treated according to
      standard medical practice.
    

Intervention name(s): Ad5-SGE-REIC/Dkk3
Intervention type(s): Drug
Intervention description(s): Ad5-SGE-REIC/Dkk-3, was designed to increase intracellular production REIC protein. The adenovirus vector is a transport mechanism to infuse the REIC protein into the cell providing a temporary transfusion of protein that induces apoptosis in target cancer cells, but does not appear to have a significant effect on normal tissues.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: prostate cancer; adenocarcinoma of the prostate
Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents
Condition: Self-Harm; Depression; Suicide
MeSH terms: Suicide; Self-Injurious Behavior
Study type: Interventional
Phase: Phase 2

Summary: 
      To measure NAC-induced changes to concentrations of glutathione (GSH) in the anterior
      cingulate cortex (ACC) as measured by magnetic resonance spectroscopy (MRS) in 36 adolescents
      and young adults with NSSI (12 in each group: high, low, and placebo).
    

Detailed description: 
      This study is a double-blind, placebo controlled, 4-week course of two-tiered
      N-acetylcysteine (NAC) dosing focused on identifying the optimal dose to achieve meaningful
      change in measurable biomarkers (glutathione and glutamate).

      This design will allow us to confirm acute biological changes, select the optimal dose for
      achieving biological effects, and examine dose/concentration-response relationships with
      respect to biological markers and pharmacokinetics.

      Brief schedule of activities: Subjects will be recruited through community and clinical
      settings and screened over the phone. There will be a total of 4 in-person visits and two
      sets of on-line study activities.

      Eligible participants will be assigned to one of 3 groups (double-blinded): a low-dose NAC
      group (3600 mg/day), a high-dose NAC group (5400mg/day), and placebo (PBO). The study
      intervention period is 4 weeks. Total participation is up to 8 weeks, depending on the length
      of time between Day 0 and Day 1.

      The investigators will recruit 36 adolescents and young adults aged 16-24 years. There will
      be 12 participants in each group (PBO, 3600mg/day, 5400mg/day). The investigators will use a
      minimization procedure to ensure that the participants in these 3 groups will have similar
      age, clinical severity and medication status.
    

Intervention name(s): N-acetyl cysteine; Placebo oral tablet
Intervention type(s): Drug; Drug
Intervention description(s): 3600 or 5400 mg/day N-acetyl cysteine; Placebo
Other intervention name(s): N-acetylcysteine
Intervention MeSH terms: Acetylcysteine; N-monoacetylcystine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Instrument-assisted Soft Tissue Mobilization Versus Integrated on Mechanical Neck Pain
Condition: Non-specific Chronic Mechanical Neck Pain
MeSH terms: Neck Pain
Study type: Interventional

Summary: 
      the aim of this study is to investigate the efficacy of instrumented assisted soft tissue
      mobilization versus integrated neuromuscular inhibition technique on mechanical non-specific
      neck pain
    

Detailed description: 
      Mechanical neck pain is a prevalent condition in various populations. Neck pain occurrence is
      affected by several factors, involving environmental, psychological, and social aspects. Neck
      pain represents the fourth major disorder responsible for a person's year lived with
      disability and ranked eleventh as disability-adjusted life years of a person. The neck pain
      incidence ranges from 10.4 to 23.3% in 1-year time, while the range of prevalence was 0.4 to
      86.8%. It has a high prevalence among computer users, office workers, and females, especially
      females aged 35 to 49 years old. Myofascial trigger point (MTrP) might play an important role
      in the formation of mechanical neck pain and is known as a hyperirritable spot in skeletal
      muscle that is accompanied with a hypersensitive palpable nodule in a taut band. IASTM and
      integrated play an important role in the treatment of mechanical neck pain.this trial has
      three groups; one will receive IASTM+ conventional, the second will receive integrated +
      conventional and the third will receive conventional treatment for four week
    

Intervention name(s): instrument assisted soft tissue mobilization; integrated neuromuscular inhibition technique; conventional therapy
Intervention type(s): Other; Other; Other
Intervention description(s): the patients will receive instrument-assisted soft tissue mobilization:The subject was seated in a relaxed sitting position. M2T blade was used to find specific areas of restriction on RT upper trapezius. Then treatment plane 1 - 2 and 3 were used.The lubricant (Vaseline) was applied to the skin around the neck area prior to treatment and the tool was cleaned with an alcohol preparation pad. Then by using M2T blade with angle 45, we were giving long slow strokes without causing any discomfort or pain over muscle starting from its insertion up to its origin approximately for 2 to 3 min repeated two times.; will receive integrated neuromuscular inhibition technique: from supine lying position.we the patients will perform ischemic compression at trigger points then positional release technique and finally muscle energy technique.; the patients will receive hot back for 10 minutes, active range of motion exercise, chin tuck, stretches
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: instrument assisted soft tissue mobilization and integrated neuromuscular inhibition technique
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: instrument-assisted soft tissue mobilization; integrated neuromuscular inhibition technique
Prophylactic Antimalarial Activity of DB289 in Volunteers
Condition: Prophylactic Activity Against Malaria
MeSH terms: Malaria
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      To evaluate the prophylactic activity of orally administered DB289 against Plasmodium
      falciparum in non-immune healthy volunteers who are challenged by the bite of five P.
      falciparum-infected Anopheles stephensi mosquitoes
    

Detailed description: 
      The primary endpoint of this study is the appearance of erythrocytic parasites (parasitemia),
      which indicates a prophylaxis failure. Parasitemia will be sought by multiple means,
      including blood culture, polymerase chain reaction (PCR), Quantitative Buffy Coat (QBC)
      analysis, and thick and thin blood smears (detailed methods,Appendix II).

      QBC and giemsa-stained blood smears will be analyzed in real time and a positive result in
      any one of them is sufficient to initiate chloroquine treatment. All positive QBC analyses or
      blood smears will be confirmed by two experienced observers. On smears, the location of
      parasites will be recorded using a stage micrometer, and slides will be archived and
      available for later re-examination. PCR samples will be collected and stored for later
      analysis; cultures will be inoculated at once and maintained for 70 days.

      A positive result in any one of these tests constitutes a drug failure.
    

Intervention name(s): DB289
Intervention type(s): Drug
Intervention MeSH terms: Pafuramidine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Prevention
Keywords: prophylactic; malaria; challenge
Trial to Investigate Immune Responses Elicited by a Liquid Formulation of Influenza Virus Vaccine(CAIV-T)in Healthy Adults Aged 18 to 59 and Healthy Adults Aged 60 Years and Older
Condition: Influenza
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this clinical study was to evaluate immune responses measuring antibodies in
      serum and secretions and cellular immune responses generated by CAIV-T vaccine in healthy
      adults aged 18 years and older as a means to develop assays for application in investigating
      potential immunological correlates of protection and/or establishing assays to measure
      vaccine take.
    


Intervention name(s): CAIV-T or TIV
Intervention type(s): Biological
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Prevention
Right Ventricular Function and Exercise Capacity in Patients With Continuous-flow Left Ventricular Assist Devices
Condition: Heart Failure
MeSH terms: Heart Failure
Study type: Interventional

Summary: 
      Exercise capacity in continous-flow left ventricular assist device (CF-LVAD) patients remains
      severely reduced post-implant. While the effect of right ventricular (RV) failure early after
      pump implantation, and its effect on outcome has been extensively studied, the effects of
      late RV failure on exercise capacity and quality of life (QOL) has been sparsely described.
      Thus the purpose of this study is to examine RV function and the association to exercise
      capacity in CF-LVAD patients.
    

Detailed description: 
      When pharmacological therapy becomes insufficient in advanced end-stage heart failure (HF)
      transplantation remains the gold standard of therapies. However, due to a severe lack of
      donor organs, mechanical circulatory support is an alternative option for some eligible
      patients. Mechanical circulatory support in the form of a CF-LVAD is a pump supporting the
      left ventricle by pumping blood from the apex to the ascending aortae. Implantation with a
      CF-LVAD increases survival and improves quality of life, but peak oxygen uptake (peak VO2)
      remains severely reduced post-implant. Complex central and peripheral hallmarks of heart
      failure attribute to the continued work intolerance. Furthermore a fixed CF-LVAD pump speed
      prevents adequate circulatory support during strenuous exercise. The effects of late right
      ventricular (RV) failure on exercise capacity and quality of life (QOL) is, however, unknown
      and the purpose of this study is to examine RV function and the association to exercise
      capacity in CF-LVAD patients.
    

Intervention name(s): Cardiac Computed tomography
Intervention type(s): Other
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Clinical Trial to Evaluate the Safety and Immunogenicity of Mumps Vaccine
Condition: Mumps
MeSH terms: Mumps
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to evaluate the safety and immunogenicity of mumps vaccine in
      healthy infants aged 8-12months, compared with measles, mumps and rubella combined vaccine,
      live (MMRV).
    

Detailed description: 
      The study is a randomized, double-blind, controlled phase Ⅳ clinical trial. And 920 infants
      will be assigned to investigational group and controlled group in a 1:1 ratio. The
      investigational vaccine is manufactured by Sinovac (Dalian) Vaccine Technology Co., Ltd. The
      controlled vaccine is manufactured by Shanghai institute of biological products Co., Ltd.
    

Intervention name(s): Mumps vaccine; measles, mumps and rubella combined vaccine, live
Intervention type(s): Biological; Biological
Intervention description(s): One dose of mumps vaccine: 0.5 ml per dose, mumps live virus not less than 3.7 lg CCID50; One dose of measles, mumps and rubella combined vaccine, live: 0.5 ml per dose, mumps live virus not less than 4.3 lg CCID50
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Keywords: Mumps; Mumps vaccine; measles, mumps and rubella combined vaccine, live; infants
Effect of "Autogenous Leukocyte Platelet Rich Fibrin- Tooth Graft" Combination Around Immediately Placed Implants
Condition: Autogenous Tooth Bone Graft; Immediate Implant Placement; L-PRF
Study type: Interventional

Summary: 
      Immediate implant placement into fresh extraction sockets is gaining popularity because of
      fewer clinical procedures and maintenance of bone architecture compared to conventional
      methods, thus reducing the treatment time and increasing patient satisfaction. In addition,
      the survival rate of the immediate implantation is comparable to that of the healed
      implantation sites. Recently, ATBG made from compromised teeth was applied in bone defects
      and resulted in a good clinical efficacy. Moreover, it is more accepted by patients to use
      extracted teeth as a bone graft material, especially in the case of immediate implant
      placement. In 2020, Kizildağ and coworkers studied the outcome of PRF as an adjunct with ATBG
      on bone healing in rabbit peri-implant osseous defects. They reported that combination of
      ATBG with PRF contributed to significantly higher new bone formation and better bone/implant
      contact in rabbits with peri-implant bone defects. The main hypothesis behind this study is
      that using L-PRF with ATBG following immediate implant placement could promote stabilization
      of graft particles and enhance new bone formation with a shorter time. Therefore, the purpose
      of this study was to compare the clinical and radiographic outcomes of ATBG on bone formation
      with or without L-PRF around immediately placed dental implants in periodontally compromised
      teeth.
    


Intervention name(s): immediate implant placement with ATBG and L-PRF; immediate implant placement with ATBG
Intervention type(s): Combination Product; Combination Product
Intervention description(s): immediate implant placement using ATBG as a graft material, with L-PRF; immediate implant placement using ATBG as a graft material without L-PRF
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Efficacy Study Regarding the Beneficial Effects of Omega-3 Fatty Acids on Cardiometabolic Health
Condition: Metabolic Syndrome X
MeSH terms: Metabolic Syndrome
Study type: Interventional

Summary: 
      Fish oil supplements (which are rich in omega-3 fatty acids) have been shown to provide
      cardiometabolic benefits to individuals of all ages. Specifically, the daily consumption of
      fish oil supplements has been reported to reduce blood triglyceride levels, and influence
      glucose homeostasis and whole-body inflammation. However, recent evidence highlights
      important gaps in our understanding with respect to the impact of fish oil supplements on
      health; specifically, not everyone responds to these supplements in the same manner. The goal
      of this research is to explore how an individual's genetic make-up may modify their response
      to fish oil supplements.
    

Detailed description: 
      The typical Western diet is now recognized to have insufficient amounts of omega-3 fatty
      acids (in particular EPA and DHA). These fatty acids have several known health benefits,
      including improvements in heart health, metabolic syndrome, and inflammation. These benefits
      occur because omega-3 fatty acids can regulate a myriad of cellular functions. In order to
      increase the levels of these omega-3 fatty acids in the body, individuals must either consume
      more marine products or take an omega-3 rich dietary supplement, such as fish oil. While fish
      oil supplements are commonly consumed by people, it is now recognized that not everyone
      responds to these supplements in the same manner. Therefore this study aims to improve our
      understanding of why people respond differently to the same dietary supplement. The goals of
      this research will be accomplished using a number of approaches:

        1. The investigators will examine how fish oil supplementation leads to an enrichment of
           EPA and DHA in various cells throughout the body (erythrocytes, adipose tissue, etc).

        2. The investigators will determine the dynamic changes in EPA and DHA incorporation into
           different cell-types during distinct phases of our dietary intervention study (e.g.
           during supplementation and subsequent wash out periods).

        3. The investigators will study how fish oil supplements influence various blood markers of
           cardiometabolic health (e.g. triglycerides, cholesterol, glucose, C-reactive protein,
           etc) and whether this is modulated by an individual's genotype.
    

Intervention name(s): Fish oil supplement
Intervention type(s): Dietary Supplement
Intervention description(s): Participants are instructed to consume fish oil supplements on a daily basis for a 3-month period.
Other intervention name(s): Jamieson Omega-3 complete supplements; Ocean Nutrition MEG-3 supplements
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Fish oil; EPA; DHA; fatty acids; genetic variation; gene expression
A Study to Assess the Reliability/Feasibility of Using Emerald Touchless Sensor for Scratching and Sleep Quantification in a Subset of Participants From PEDISTAD Study (OBS15333; NCT03687359)
Condition: Dermatitis Atopic
MeSH terms: Dermatitis, Atopic; Dermatitis
Study type: Observational

Summary: 
      Primary objective: To explore and quantify the association between nighttime scratching and
      sleep patterns objectively in pediatric participants with moderate to severe atopic
      dermatitis (AD) using an innovative Emerald touchless sensor.

      Secondary objective: To evaluate the feasibility of using the Emerald touchless sensor in a
      pediatric clinical trial setting.
    

Detailed description: 
      16 weeks
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Only participants enrolled in the OBS15333 pediatric AD registry (PEDISTAD) in the United
        States (US) study sites will be allowed to participate in this study.