bioihbjkbjnl/mcl2 huggingface dataset:
Sensorimotor Training Versus Resistance Training in Patients With Knee Osteoarthritis
Condition: Knee Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      People with knee osteoarthritis (OA) have functional instability and defective neuromuscular
      function, it was recently suggested that sensorimotor exercises may be important and needed
      to improve the effectiveness of training programs for these patients. This study objective
      was to compare the effectiveness of a supervised resistance muscular training (RT) versus
      sensorimotor training (SMT) for patients with Knee OA, on decrease of pain and functional
      improvement.
    


Intervention name(s): Sensorimotor training (SMT); Resistance training (RT); Control group (CG)
Intervention type(s): Other; Other; Other
Intervention description(s): The group realized 16 weeks of sensorimotor training, twice a week, with duration of 30 minutes each session. The intervention included agility and coordination exercises, perturbation training and stretching exercises. Also, the participants received orientation about the knee osteoarthritis.; The group realized 16 weeks of resistance training for the quadriceps and hamstring muscles, twice a week, with duration of 30 minutes each session. The intervention included strength leg raises, simple quadriceps and hamstring strengthening with cuff weights realized in 3 sets of ten repetition maximum(10RM) for each muscle group. The group also realized stretching exercises for lower limbs and received orientation about the knee osteoarthritis.; Patients in this group also received information about knee osteoarthritis and realized the same warm-up and cool-down intervention realized in the interventional groups. During 16 weeks they went to the ambulatory twice a week to perform 5 minutes of stationary bicycle and 5 minutes of stretching exercises for lower limbs.
Other intervention name(s): Agility/perturbation training; proprioceptive training; neuromuscular training
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: knee osteoarthritis; exercise therapy; resistance training; proprioception
Study Comparing a Soybean Oil-Based With an Olive Oil-Based Lipid Emulsion in ICU Patients Requiring TPN
Condition: Parenteral Nutrition
MeSH terms: Insulin Resistance
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      Many hospitalized patients who are malnourished or not eating receive intravenous feeding or
      total parenteral nutrition (TPN). Despite improving nutrition, TPN may increase the risk of
      infections and hospital complications. We do not know why TPN increases hospital
      complications, but it may be caused by the high sugar or fat content in TPN solutions.
    

Detailed description: 
      This study compares the effect of a soybean oil-based versus an olive oil-based lipid
      emulsion in healthy volunteers and in critically ill patients. In healthy volunteers, your
      blood sugar levels, blood vessel function, and your ability to fight infections will be
      examined. In ICU patients, we examines whether use of the olive oil-based lipid emulsion may
      decrease the risk of infection and hospital complications.
    

Intervention name(s): ClinOleic 20% Intravenous Emulsion; Intralipid, 20% Intravenous Emulsion
Intervention type(s): Drug; Drug
Intervention description(s): ClinOleic 20% is a lipid emulsion containing a mixture of refined olive oil (approximately 80%) and refined soybean oil (approximately 20%) corresponding to an essential fatty acid intake of approximately 20% of the total fatty acids intake.; It is made up of 20% Soybean oil, 1.2% egg yolk phospholipids, 2.25% glycerin, and water for injection
Other intervention name(s): Lipid Emulsion; 20% i.v. fat emulsion
Intervention MeSH terms: Soybean oil, phospholipid emulsion
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: parenteral nutrition; lipid emulsion; nosocomial infection; mortality; endothelial function; inflammatory markers; oxidative stress; immune function; autonomic nervous system; insulin sensitivity; carbohydrate metabolism
Posttraumatic Hypopituitarism - Incidence, Predictors and Test Validity
Condition: Traumatic Brain Injury; Hypopituitarism
MeSH terms: Brain Injuries; Brain Injuries, Traumatic; Hypopituitarism
Study type: Observational

Summary: 
      The purpose of the study is to estimate the incidence of posttraumatic hypopituitarism, and
      to identify predisposing factors in order to establish a rational responsible socioeconomic
      screening program.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients hospitalised with a traumatic brain injury at any danish hospital between
        01.01.2008 - 31.12.2008
      
Biospecimen description: 
      Serum and plasma
    
Keywords: Traumatic brain injury; Hypopituitarism; Incidence
Thorough QT Study of Nelfinavir
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 4

Summary: 
      To assess if nelfinavir has any clinically meaninful effect on cardiac function, namely ECG
      evaluation
    


Intervention name(s): Nelfinavir
Intervention type(s): Drug
Intervention MeSH terms: Nelfinavir
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double
Primary purpose: Treatment
Prevention Of Nephrotoxicity Following Bone Marrow Transplantation Using Urodilatin and Mannitol
Condition: Renal Dysfunction; Acute Renal Failure; Mortality
MeSH terms: Renal Insufficiency; Acute Kidney Injury
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of the study is to combine Urodilatin (ANP analogue), which will increase
      glomerular filtration rate (GFR), and mannitol, which will increase the rate of urinary flow
      and solute excretion. We intend to treat twenty consecutive allogeneic bone marrow transplant
      patients in a phase II study comparing results with historical controls.

      We hypothesize that the incidence of renal dysfunction, ARF and thus mortality in allogeneic
      bone marrow transplantation can be significantly reduced by the use of protective agents
      Urodilatin and mannitol. We feel that this combination is best administered prior to and
      during the first two weeks of treatment when patients encounter immunosuppressive agents and
      the onset of early transplantation complications.
    


Intervention name(s): URODILATIN (ULARITIDE, ATRIAL NATRIURETIC PEPTIDE); MANNITOL
Intervention type(s): Drug; Drug
Intervention MeSH terms: Mannitol; Ularitide
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Urodilatin; Mannitol; Acute Kidney Failure
Urgent Medical and Surgical Conditions During Flights
Condition: Syncope; Arrest; Vertigo; Pain; Chronic Obstructive Pulmonary Disease; Hypertension; CAD
MeSH terms: Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive; Vertigo; Syncope
Study type: Observational

Summary: 
      The aim of this study is to evaluate the incidence and status of urgent medical conditions.
      After defining the urgent situations, the investigators will evaluate the adequacy of the
      standard medical kits and trainings.
    

Detailed description: 
      In this study, the incidence and status of urgent medical conditions, the attitudes of health
      professionals who encounter such conditions, adequacy of Aerospace Medical Association (ASMA)
      suggested medical kits and training of cabin crew in data-received-company aircrafts and the
      demographic data of patients have been evaluated.
    

Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        All passengers who needs urgent medical support
      
Keywords: inflight emergencies
A Study to Investigate the Pharmacokinetic Drug Interactions Between Dutasteride and Tadalafil in Healthy Male Subjects
Condition: Benign Prostate Hyperplasia
MeSH terms: Prostatic Hyperplasia; Hyperplasia
Study type: Interventional
Phase: Phase 1

Summary: 
      This is open-Label, A Randomized, Crossover study to evaluate the safety and pharmacokinetic
      interaction after oral concomitant administration of Dutasteride and Tadalafil in healthy
      male volunteers.
    


Intervention name(s): Tadalafil; Dutasteride
Intervention type(s): Drug; Drug
Intervention MeSH terms: Tadalafil; Dutasteride
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Dutasteride; Tadalafil
Laryngeal Mask Position in Magnetic Resonance Imaging in Children
Condition: Laryngeal Mask Malposition
Study type: Observational

Summary: 
      The aim of the trial is to obtain and to describe the position of the laryngeal mask during
      elective magnetic resonance imaging in paediatric patient. The radiologic findings will be
      compared to the clinical performance of the laryngeal mask.
    

Detailed description: 
      Properly inserted laryngeal mask (LMA) with good clinical performance can be misplaced (on
      radiological imaging) but with not know effect on clinical practice. The percentage of the
      misplaced LMAs are relatively high, but the exact number in paediatric population is
      currently not clear. The aim of this prospective observational cohort study is to describe
      the percentage of misplaced LMAs during elective magnetic resonance imaging (MRI) in
      paediatric patient. After approval of the local ethical committee all elective paediatric
      patients in study interval (10/2016-3/2017) indicated for elective MRI of the brain or
      elective MRI of the brain and cervical spine will be included to the trial. Demographic
      characteristics - age, weight, comorbidities, anesthesia management - education of
      anesthesiologist, type of LMA, number of insertion attempts, clinical performance of the LMA,
      presence/absence of leak, the peak inspiratory pressure (mechanical ventilation), volume of
      air in cuff, complications during anesthesia and LMA soil after extraction - blood, saliva,
      mucus, gastric content. The clinical performance will be compared to the LMA position on MRI
      - position of the proximal and the distal site of the LMA cuff according to the cervical
      vertebrae, displacement of the epiglottis, distance between proximal LMA cuff and vocal
      cords, distance between distal LMA cuff and vocal cords.
    

Intervention name(s): Magnetic resonance imaging
Intervention type(s): Radiation
Intervention description(s): No intervention - description of the position of the LMA obtained during routine elective MRI scanning of the brain and/or cervical spine
Other intervention name(s): MRI
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Paediatric patients undergoing elective magnetic resonance imaging of the head (brain)
        and/or head (brain) and cervical spine
      
Keywords: Laryngeal mask,MRI
SGLT2 Inhibition and Stimulation of Endogenous Glucose Production: Protocol 2
Condition: Type II Diabetes Mellitus
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 3

Summary: 
      In Protocol 2, the investigators will determine the role of pancreatic hormones (increase in
      plasma glucagon and decrease in plasma insulin concentration) in the stimulation of EGP
      following SGLT2 inhibition.
    

Detailed description: 
      The inhibition of the renal (kidney) SGLT2 transporter has proven to be an effective
      therapeutic intervention to reduce plasma glucose levels (amount of glucose found in the
      liquid part of blood) and HbA1c.

      In this study, the investigators hope to define the role of increased plasma glucagon,
      decline in plasma insulin, and fall in plasma glucose concentration. The investigators will
      examine whether the signal for the increase in EGP (endogenous glucose production) caused by
      glucosuria (an excess of sugar in the urine, typically associated with diabetes) is mediated
      via the decrease in plasma glucose and insulin concentrations, or by the increase in plasma
      glucagon concentration.
    

Intervention name(s): Dapagliflozin; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): SGLT2 inhibitor (dapagliflozin); Placebo Comparator
Other intervention name(s): Farxiga
Intervention MeSH terms: Dapagliflozin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette's Disorder
Condition: Chronic Motor or Vocal Tic Disorder; Tourette's Disorder
MeSH terms: Tics; Tic Disorders; Tourette Syndrome
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this trial is to demonstrate the efficacy and safety of aripiprazole in
      children and adolescents aged 6~18 years with chronic tic disorders or Tourette's disorder
    


Intervention name(s): aripiprazole; placebo
Intervention type(s): Drug; Drug
Intervention description(s): Initial dose : 2mg, Maximum dose : 20mg; Initial dose: 2mg, Maximum dose:20mg
Other intervention name(s): Abilify
Intervention MeSH terms: Aripiprazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Chronic Motor Tic disorder; Chronic Phonic Tic disorder; Tourette's disorder; Aripiprazole; Abilify; Children; Adolescent
Effect of Two Different Methods on Pain and Anxiety
Condition: Pain
Study type: Interventional

Summary: 
      The aim of this study is to determine the effect of virtual reality glasses and ball
      squeezing method used during peripheral intravenous catheter placement on pain and
      anxiety.The hypotheses of this research are that virtual reality glasses and a stress ball
      reduces pain and anxiety.
    

Detailed description: 
      This study was designed as a pretest-posttest regular parallel group, randomized controlled
      experimental. The research will be carried out in the general surgery clinic of Necmettin
      Erbakan University Meram Medical Faculty Hospital. Patients will be randomly assigned to
      three groups: ball squeezing (37), virtual reality glasses (37) and control group (37). For
      Virtual Reality Glasses Group: The video containing the nature walk will be watched by
      virtual reality. 3 minutes after the individual starts watching the video, the IV catheter
      insertion attempt will be performed while continuing to watch the video. For Ball Squeezing
      Group: Patients will be given a ball and instructed to tighten and loosen with their free
      hand during intravenöz catheter placement. The intravenöz catheter insertion attempt will be
      made while the patient continues to squeeze the ball. For Control Group: No application will
      be made during intravenous catheter placement in the control group.The primary outcome of
      this study was to determine the patients' pain scores during the peripheral venous cannula
      insertion process.The secondary outcomes of the study were to determine the patients' anxiety
      levels.
    

Intervention name(s): Virtual Reality Glasses; Stress Ball
Intervention type(s): Device; Device
Intervention description(s): 3 minutes after the individual starts watching the video, the IV catheter insertion attempt will be performed while continuing to watch the video.; Patients will be given a ball and instructed to tighten and loosen with their free hand during IVC placement. The patient will continue to squeeze the ball throughout the IV catheter insertion attempt.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Peripheral Intravenous Catheter Insertion; Pain; Anxiety
Detection of Aggressive Breast Tumors Using Tc-99m-NC100692
Condition: Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Observational

Summary: 
      The purpose of this study is to compare two types of radioactive drugs to see if they provide
      the same or different information about any disease that may be present in the participants
      breast.
    


Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients that are scheduled for a biopsy at the Mayo Clinic in Rochester, MN. The patients
        must have a suspicious lesion
      
Keywords: MBI; Molecular Breast Imaging; Breast; Breast Cancer; Molecular Imaging
A Dose Linearity Study of the Labopharm Formulation of Tramadol HCl/Contramid®, 100 mg, 200 mg and 300 mg After A Single Oral Administration In Fasting Condition, In Healthy Human Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purposes of this study were:

        -  To evaluate the plasma pharmacokinetic profile of tramadol and its principal metabolite,
           the O-desmethyltramadol, after a single oral administration of 100, 200 and 300 mg of
           tramadol as the Labopharm extended-release formulation prepared with Contramid.

        -  To assess the dose linearity of tramadol and its principal metabolite, the
           O-desmethyltramadol, between 100 mg and 300 mg following a single dose administration of
           the Labopharm extended-release formulation prepared with Contramid under fasting
           conditions in young healthy volunteers.
    


Intervention name(s): Tramadol HCl
Intervention type(s): Drug
Intervention description(s): One single oral administration of Tramadol HCl 100 mg, 200 mg or 300 mg as per randomization schedule.
Intervention MeSH terms: Tramadol
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: Healthy volunteers
Progressive Resistance Training in Patients With Class III Obesity
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional

Summary: 
      To test the strength and physical performance outcomes of a 12-week progressive resistance
      training (PRT) exercise program in a small cohort of patients with Class III obesity who are
      preparing for bariatric weight loss surgery at Beth Israel Deaconess. The study will also
      test patient compliance to the 12 week PRT program. Whereas PRT exercise is currently
      recommended as a part of preoperative clinical care for bariatric surgery patients, little
      research has been done to measure the acceptance and effectiveness of a standardized PRT
      exercise protocol for improving health and perioperative care. Preliminary data from this
      study could be used to justify larger studies and further investigation.
    


Intervention name(s): Progressive Resistance Training
Intervention type(s): Behavioral
Intervention description(s): 12-week progressive resistance training (PRT) exercise program
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: bariatric surgery; class III obesity; resistance training; strength; fitness
Clinical Evaluation Gastrointestinal Motility With PillCam
Condition: Gastrointestinal Motility
Study type: Observational

Summary: 
      The purpose of this study is to evaluate the clinical usefulness of a video camera pill
      (PillCam) in assessing intestinal function in the small intestines of patients. It is
      believed that the condition of the subjects digestive system can have a large impact on their
      overall physical health. Therefore, the investigators would like to assess whether using the
      pill device helps to determine any functional problems in patients in the ICU. The
      investigators are studying ICU patients because any change in their condition can have a
      large impact on their recovery. The same device will be used in healthy subjects scheduled
      for elective ambulatory surgery.
    


Intervention name(s): PillCam
Intervention type(s): Device
Intervention description(s): Within four days of hospital admission, qualifying critically ill patients were assigned to the study and received a gastro-jejunal tube and one PillCam video telemetry capsule (Given Imaging Ltd., Yoqneam, Israel). In each critical care patient, placement of the video capsule was coupled with the placement of the medically necessary feeding tube. A flexible endoscope was inserted into the patient's mouth, and then advanced into the esophagus, stomach, and upper small intestine. The capsule was placed into a capsule delivery device and released into the distal duodenum after it had passed beyond the sight of the scope; a wire was placed to facilitate passage of the feeding tube. An abdominal X-ray was obtained to confirm feeding tube tip placement.
Other intervention name(s): PillCam video telemetry capsule, Given Imaging Ltd.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Critically ill patients (i.e., all were intubated, mechanically ventilated and sedated) and
        healthy patients scheduled for an outpatient procedure.
      
Keywords: Critical care; Endoscopy, Video Capsule; Nutrition, Enteral
Prophylactic Negative Pressure Dressings for Closed Laparotomy Wounds - A Randomised, Controlled, Open Label Trial
Condition: Infection
Study type: Interventional
Phase: Phase 2

Summary: 
      Laparotomy wounds are associated with high rates of surgical site infections (SSI). The
      effect of prophylactic negative pressure dressing of closed incisional wounds on SSI rates is
      inconclusive.
    


Intervention name(s): Negative pressure dressing; Standard wound dressing
Intervention type(s): Device; Device
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Omega-3 Fatty Acids in Chronic Periodontitis.
Condition: Chronic Periodontitis
MeSH terms: Periodontitis; Chronic Periodontitis
Study type: Interventional
Phase: Phase 4

Summary: 
      Omega 3 fatty acids is one such dietary supplement, known to modulate the host response in
      chronic conditions like cardiovascular diseases, rheumatoid arthritis, ischemic
      cerebrovascular diseases, osteoporosis by producing Resolvins and protectins without showing
      any inadvertent effects.Addition of systemic Omega 3 Fatty Acids with SRP may enhance the
      therapeutic result of Chronic Periodontitis owing to host modulation & anti-inflammatory
      properties. If proven, this can be used as a routine treatment modality.
    


Intervention name(s): Omega 3 fatty acid; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Patients with Chronic Periodontitis in Test Group were prescribed Omega 3 fatty acid tablets 300mg once daily for 12 weeks and SRP at baseline; Patients with Chronic Periodontitis in Control Group were prescribed Placebo tablets once daily for 12 weeks and SRP
Other intervention name(s): Mega-3
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Omega 3 fatty acids; C Reactive Protein; Host Modulation; Chronic Periodontitis