bioihbjkbjnl/mcl2 huggingface dataset:
Testing the Effectiveness and Safety of a Passive Industrial Exoskeleton for the Upper Limb
Condition: Prevention of Diseases of the Musculoskeletal System
Study type: Interventional

Summary: 
      This research will provide data on evaluation of the effectiveness and safety of using a
      passive exoskeleton designed to reduce the negative impact of static and dynamic loads
      associated with lifting and holding weights and having workspace over head on the
      musculoskeletal system of workers. To evaluate a passive industrial exoskeleton for upper
      limb support, a protocol was developed in which individual production operations will be
      modeled.
    

Detailed description: 
      This research will recruit 12 volunteers. During a 4-hour laboratory visit, each subject will
      perform two identical experimental tests: one test without an exoskeleton and another one
      using the exoskeleton. To avoid sequence bias, the test order will be randomized (balanced).
      The labor operation will be simulated. This operation's cycle will consist of lifting the
      load, which is 5-10 kg off the table, holding it over head and touching 4 points in order on
      a horizontal plate for 2 min. After this volunteer is resting for 1 min. The work will be
      performed for 105 minutes, then a break of 15 minutes, then 105 minutes of work. Heart rate
      (Polar) will be monitored. An ergospirometric device (Metamax) will be used to collect muscle
      activity data (Trust-M, Myoton), inertial sensors (Trust-M) will be used to evaluate the
      biomechanics of movements. In addition, questionnaires will be filled out for a subjective
      assessment of the use of exoskeleton prototypes (local discomfort scale, exoskeleton
      properties assessment questionnaire).
    

Intervention name(s): Passive industrial exoskeleton for the upper limb; The protocol will be performed without exoskeleton
Intervention type(s): Device; Other
Intervention description(s): The goal is to compare the human response to the simulated industrial tasks; The protocol will be performed without exoskeleton
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Randomized counterbalanced cross-over design
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: industrial exoskeleton; exoskeleton; passive industrial exoskeleton
To Determine the Effectiveness of Saddle Block vs Spinal Anesthesia in TURP
Condition: Haemodynamic Instability
Study type: Interventional
Phase: Phase 3

Summary: 
      To determine the effectiveness of saddle block vs spinal anesthesia in TURP.
    

Detailed description: 
      This study is being conducted to determine the effectiveness of saddle block vs spinal
      anesthesia in terms of haemodynamic stability and Vasopressor usage.
    

Intervention name(s): 0.5% Hyperbaric Bupivacaine
Intervention type(s): Drug
Intervention description(s): In both groups 0.5% Hyperbaric Bupivacaine is given intrathecally and then saddle group is advised to stay in sitting position for next 5minutes so that drug can block only lower segments of nerves, Lumber 5th to Sacral dermatomes level. The spinal group is advised to take supine position immediately so that drug distribution be uniform uptill T10 level of spinal dermatome. Then outcomes regarding haemodynamic status and vasopressor usage are recorded
Other intervention name(s): Hyperbaric Bupivacaine
Intervention MeSH terms: Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: In Both the groups after injecting 0.5% hyperbaric Bupivacaine intrathecally the outcomes are monitored and compared.
Masking: None (Open Label)
Primary purpose: Treatment
Assessment of Dyslipidemic Patients' Knowledge, Quality of Life, and Adherence
Condition: Dyslipidemias
MeSH terms: Dyslipidemias
Study type: Interventional

Summary: 
      A randomized, parallel two-arm interventional study, the patients were divided into 1:1
      ratio, in which both groups offered optimal pharmacological therapy also one group
      (interventional) offered predesign pharmaceutical care plan aimed to improved patients
      knowledge, adherence, satisfaction, and quality of life, while the other group
      (non-interventional) received conventional pharmaceutical care plan.
    


Intervention name(s): Pharmaceutical care plan
Intervention type(s): Behavioral
Intervention description(s): The design of the intervention was based on a stepwise approach to address the following point in each participant: set priorities for patient care, assessment of patient's educational needs, and development of a comprehensive and achievable pharmaceutical care plan.
The participants will be educated about their illness and informed about the proper use of their medication in a structured manner (it involved the following items: dyslipidemia as a disease, complications, who therapy reduces its risk and complications, goal of therapy). Behavioral modifications will involve the following: physical exercise, diet, smoking cessation. Patients will obtain this information verbally and provided in a written manner through a brochure that design for this study.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Rehabilitation After Arthroscopic Partial Meniscectomy
Condition: Knee Pain
Study type: Interventional

Summary: 
      Water-Based vs. Land-Based Rehabilitation After Arthroscopic Partial Meniscectomy in
      Middle-Aged Active Patients with a Degenerative Meniscal Tear: A Randomized, Controlled Study
    

Detailed description: 
      In this study, we aimed to determine and compare the benefits of water-based exercise (WBE)
      and land-based exercise (LBE) on pain, functionality, and quality of life after arthroscopic
      partial meniscectomy (APM). Middle-aged (35-50), active 30 patients having APM for a
      degenerative meniscal tear randomized into LBE (n=15) and WBE (n=15) groups. The pain level
      (visual analogue scale [VAS]), isokinetic muscle strength, quality of life (Short Form-36
      [SF-36]), and function level (single-leg hop test and Lysholm questionnaire) were evaluated
      prior to treatment and at follow-up visits at the fourth and eighth week after surgery. The
      exercise sessions were conducted 3 times a week for 4 weeks in both groups.
    

Intervention name(s): Land based exercise; Water based exercise
Intervention type(s): Other; Other
Intervention description(s): The patients who had land based exercise; The patients who had water based exercise
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Rehabilitation; Exercise; Aquatherapy
The Length of the Right Main Stem Bronchus as a Guide to Right-sided Double-lumen Tube Use
Condition: Therapeutic Procedural Complication
Study type: Interventional

Summary: 
      The Length of the Right Main Stem Bronchus Measured by Computerised Tomography as a Guide to
      Right-sided Double-lumen Tube Use
    

Detailed description: 
      The double lumen tube (DLT) is the most popular way to isolate the lungs for thoracic
      surgery. The variable anatomy of the length of the right main stem bronchus seems to be the
      main reason clinicians are unwilling to use the right-sided DLT (R-DLT). The factors that
      could compromise the adequate ventilation of the right lung are mostly the variable length of
      the Right Main Stem Bronchus and the misalignment of the lateral orifice of the right-sided
      DLT in regard to the right upper lobe bronchus (RULB). The objectives of this study were to
      validate an alternative method to estimate the length of the Right Main Stem Bronchus by
      Computerised Tomography as a Guide to Right-sided Double-lumen Tube Use
    

Intervention name(s): the Length of Right Main Stem Bronchus
Intervention type(s): Other
Intervention description(s): The distance between the carina and the proximal margin of the right upper lobe orifice on the coronal plane measured by computerised tomography
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Other
Laser Hair Removal for Treatment of Pilonidal Disease
Condition: Pilonidal Disease
Study type: Interventional

Summary: 
      This project is a pilot study to determine if symptomatic pilonidal disease can be primarily
      managed with laser hair removal vs surgery.
    

Detailed description: 
      This project will consist of surgical evaluation in pediatric surgery or colorectal surgery
      clinics, referral to dermatology clinic for informed consent, and if enrolled, participation
      in up to 8 laser hair removal sessions with regular follow-up for a period of 2 years after
      completion of therapy.
    

Intervention name(s): Laser hair removal
Intervention type(s): Procedure
Intervention description(s): Those who consent to participate in the study will be treated with up to 8 sessions of laser hair removal utilizing a long-pulsed laser to the natal cleft at treatment intervals of 4-6 weeks.
Other intervention name(s): Laser depilation
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Psychosocial Consequences of the Screening of Von Hippel Lindau Diseases for Patients Operated for a hémangioblastoma of Nervous Centrasl System
Condition: Hemangioblastoma (HB) of the Central Nervous System (CNS)
MeSH terms: Hemangioblastoma
Study type: Interventional

Summary: 
      Von Hippel-Lindau (VHL) disease is a severe autosomal dominant genetic disorder (with almost
      complete penetrance) that predisposes to many tumors including some associated with a poorer
      outcome. Clear cell renal cell carcinoma (CCRCC) is the leading cause of mortality.

      The diagnosis of VHL disease may be challenging because tumors have an asynchronous and
      multi-organ development and there is often no apparent hereditary context. As it is admitted
      that VHL disease is underdiagnosed, some countries have decided to recall patients presenting
      one of the potentially VHL disease-associated tumors to screen them for VHL mutation.
      Screening is currently recommended in guidelines but many patients may have not been
      previously screened.

      Hemangioblastoma (HB) of the Central nervous system (CNS) is one of the typical VHL tumors
      and up to 20% of patients with HB show VHL mutation. VHL diagnosis in this population enables
      the diagnosis of other tumor types at an early stage of development since HB is
      chronologically the second tumor occurring during the VHL disease history.

      But it raises critical problems and questions: difficult announcement of a potentially severe
      disease and psychosocial dimension related to inheritance of the disease.
    


Intervention name(s): evaluation of anxiety with psychosocial scales
Intervention type(s): Other
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Efficacy of Clarithromycin and Flouroquinolones Based Regimens in H.Pylori Eradication in Covid-19 Era
Condition: Helicobacter Pylori Infection
Study type: Interventional

Summary: 
      Era of COVID-19 and the related panic lead to widely spread antibiotics misuse especially for
      azithromycin. Cross sensitivity between azithromycin and clarithromycin can impact success
      rates of H. pylori treatment regimens.(1) Here we aim to explore this point in Egyptian
      patients.

      Sample size Supposing the cure rate of clarithromycin-based regimen to levofloxacin based
      regimen is 69% versus 84.5% respectively. Using Medcalc, the minimal required sample size is
      116 patients for each arm (type 1 error= 5%, type II error=20%). Each arm increased by 10% to
      compensate for drop-out. The sample size will be 135 for each arm.

      Study Arms:

        -  Arm 1: The first group will receive (amoxicillin 1g/12 hrs, Clarithromycin 500 mg/12hrs,
           esomeprazole 40mg/12hrs)

        -  Arm 2: The second group will receive (esomeprazole 40 mg/12hrs, levofloxacin 500 mg/24
           hrs, and amoxicillin 1gm/12 hrs).

        -  To confirm patient compliance, we will ask patients to bring their remaining medication
           and counted the rest of their pills. Patients with a compliance of <80% will be excluded
           from the study per protocol (PP) analysis.
    


Intervention name(s): Amoxicillin
Intervention type(s): Drug
Intervention description(s): Anti-H. pylori regimens
Other intervention name(s): Clarithromycin; Levofloxacin
Intervention MeSH terms: Amoxicillin; Clarithromycin; Levofloxacin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
The Effect of Quran of Post Operative Pain
Condition: Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional
Phase: Phase 2

Summary: 
      Postoperative pain management is crucial for surgical patients. Management of postoperative
      pain entails reducing painful symptoms, improving the quality of recovery and resuming normal
      daily living activities. In addition to the benefits derived from relieving postoperative
      pain in women undergoing cesarean section, prolonged immobility as a result of pain during
      puerperium is associated with risk of thromboembolic disease.

      Postoperative pain has negative physiological and psychological impact on patients'
      well-beings and delays the postoperative recovery. Pain may also impair the mother's ability
      to provide an optimal care for her infant in the immediate postpartum period. Besides that,
      it also reduces the maternal ability to breast-feed her infant effectively.

      Effective pain relief should not interfere with the mother's ability to move around and care
      for her infant, and that it results in no adverse neonatal effects in breast-feeding women.

      Non-pharmacological techniques for reduction of pain are growing rapidly. Spiritual
      intervention with listening to Quran recitations as an adjunctive therapy in the
      postoperative period is a non-pharmacological technique that is inexpensive, non-invasive and
      has no side-effects. Spiritual and Islamic implication could improve postoperative pain 6-8
      hours and 24-30 hours in Muslim patients undergoing abdominal surgery. However, there is
      limited number of published studies on the effect of spiritual and religious intervention on
      pain after cesarean section.

      Listening to Quran recitation elicits a relaxation response of calmness, mindfulness, and
      peacefulness in Muslims. Pray therapy results in optimal harmonization, which improves
      psychological, social, spiritual, and physical health status.

      The current study aims to investigate the effects of listening to Quran recitation on pain
      intensity among patients after cesarean section according to the cultural, social and
      economic differences in Egypt.
    


Intervention name(s): Quran group
Intervention type(s): Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver Disease
Condition: Alagille Syndrome; Cholestasis; Biliary Atresia
MeSH terms: Cholestasis; Biliary Atresia; Alagille Syndrome
Study type: Interventional

Summary: 
      OBJECTIVES:

      I. Determine the role of magnesium deficiency in the pathogenesis of decreased serum vitamin
      D and reduced bone density in children with chronic cholestatic liver disease.
    

Detailed description: 
      PROTOCOL OUTLINE:

      Patients receive magnesium sulfate IV over 1 hour on day 3. Patients then receive oral
      magnesium gluconate supplementation daily. Treatment with magnesium sulfate repeats once at
      3-6 months.
    

Intervention name(s): magnesium gluconate; magnesium sulfate
Intervention type(s): Drug; Drug
Intervention MeSH terms: Magnesium Sulfate
Primary purpose: Treatment
Keywords: Alagille syndrome; biliary atresia; cholestasis; gastrointestinal disorders; rare disease
Assessment of Fluoroscopy Times With Surgeon Versus Technologist Control
Condition: Urolithiasis; Kidney Stones
MeSH terms: Kidney Calculi; Nephrolithiasis; Urolithiasis; Urinary Calculi
Study type: Interventional

Summary: 
      This is a prospective randomized trial to study the effect of assigning the control of the
      fluoroscopic x-ray activation to the surgeon as compared to the radiation technologist.
      Radiation exposure will be assessed from the collected data, fluoroscopy time, and dose
      parameters (cumulative absorbed dose and dose area product). From exposure data, entrance
      skin dose (ESD) and midline absorbed dose (MLD) will be calculated. The primary outcome in
      this study will be total fluoroscopy time for the procedure. A secondary outcome will be the
      ESD. The investigators will further analyze the contribution of clinical predictors (e.g.
      stone size/location) and procedural predictors on fluoroscopy times and ESD.

      It is hypothesized that a 30% reduction in fluoroscopy time will occur when the operating
      surgeon is controlling the activation of the x-ray beam.
    


Intervention name(s): Technologist control of fluoroscopy; Surgeon control of fluoroscopy
Intervention type(s): Procedure; Procedure
Intervention description(s): Technologist control of fluoroscopy; Surgeon control of fluoroscopy
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Urolithiasis; Kidney Stones; Ureteroscopy; Fluoroscopy
High Clopidogrel Dose Versus Prasugrel and Ticagrelor in High Reactive Stable Patients
Condition: Coronary Artery Disease
MeSH terms: Coronary Artery Disease
Study type: Interventional
Phase: Phase 3

Summary: 
      Dual antiplatelet therapy with Aspirin and Clopidogrel for at least one year is essential in
      patients following an acute coronary syndrome (ACS) or percutaneous coronary intervention
      (PCI) with drug eluting stent(s) implantation. Interindividual variability in platelet
      response to Clopidogrel has been reported, with several mechanisms (intrinsic high platelet
      reactivity [PR], variability of the drug metabolism, and various drug interactions) being
      implicated for high post-Clopidogrel treatment PR. The investigators aim to perform a
      prospective, single-center, investigator-initiated, randomized, study to compare platelet
      inhibition by Prasugrel 10 mg/day, Ticagrelor (90 mg twice daily) and high-dose 150 mg/day
      Clopidogrel in patients with High on-treatment platelet reactivity (HTPR) with standard dose
      of Clopidogrel. Patients with HTPR (defined as area under curve-AUC ≥ 450 or > 45 Unit) and
      with loss-of-function allele CYP2C19*2 will be enrolled in the study and will be randomized
      (Day 0) in a 1:1:1 ratio, to either Clopidogrel 150 mg a day or Prasugrel 10 mg a day or
      Ticagrelor (90 mg twice daily) until Day-15 and-30 post randomization.
    


Intervention name(s): Clopidogrel; Prasugrel; Ticagrelor
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Patient will be randomized to this intervention will receive in the first time the double dose of clopidogrel and after 15 days and 30 days we will control the responsivness of the study drug.; Patient will be randomized to this intervention will receive in the first time prasugrel and after 15 days and 30 days we will control the responsivness of the study drug.; Patient will be randomized to this intervention will receive in the first time Ticagrelor and after 14 days and 28 days we will change their therapy with the high clopidogrel dose or Prasugrel (dual crossover).
Intervention MeSH terms: Clopidogrel; Ticagrelor; Prasugrel Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: antiplatelet effect; prasugrel; clopidogrel; stable angina
A Long-Term Safety and Efficacy Study of Eszopiclone in Elderly With Primary Chronic Insomnia
Condition: Insomnia
MeSH terms: Sleep Initiation and Maintenance Disorders
Study type: Interventional
Phase: Phase 4

Summary: 
      To evaluate the long-term safety and efficacy of eszopiclone administered for 12 weeks in
      elderly subjects with primary chronic insomnia.Administration of eszopiclone 2 mg daily at
      bedtime for 12 weeks in elderly subjects with a diagnosis of primary chronic insomnia will be
      safe and well tolerated, improve subjective sleep measures, improve measures of Quality of
      Life and next day insomnia symptoms, and have no significant withdrawal central nervous
      system adverse events or rebound insomnia.
    

Detailed description: 
      A double-blind, randomized, placebo controlled, parallel group study of eszopiclone in
      elderly subjects with primary chronic insomnia. The study will involve up to 9 visits and
      subject participation will be approximately 18 weeks. This study was previously posted by
      Sepracor Inc. In October 2009, Sepracor Inc. was acquired by Dainippon Sumitomo Pharma., and
      in October 2010, Sepracor Inc's name was changed to Sunovion Pharmaceuticals Inc.
    

Intervention name(s): Eszopiclone; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 2 mg tablet once per day in the evening; Tablet one per day in the evening.
Other intervention name(s): Lunesta
Intervention MeSH terms: Eszopiclone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: insomnia; chronic; primary
Adverse Events in Dry Needling
Condition: Muscle Soreness; Headache; Knee Osteoarthritis; Back Pain; Neck Pain; Needle Stick; Shoulder Pain; Hip Osteoarthritis
MeSH terms: Osteoarthritis; Shoulder Pain; Osteoarthritis, Hip; Myalgia; Headache; Neck Pain; Needlestick Injuries
Study type: Observational

Summary: 
      The purpose of this prospective cohort survey study is to further explore the incidence of
      adverse events with dry needling by physical therapists - as well as any differences or
      similarities between patient-reported vs therapist-reported incidence of AEs.
    

Detailed description: 
      The study design will comprise of an observational study, where practicing clinicians will
      log data from dry needling sessions and patients will report via online surveys. Clinician
      logs will be collected weekly via an online REDCap survey . Patients will be instructed to
      complete an online REDCap survey in the event that an adverse event occurs. Data will be
      collected for a period of 4 mo.

      Descriptive statistics will be used to calculate frequencies of various AE's and rates of
      occurrence per 100 treatments. Adverse events will be classified on how frequently they
      occur, ranging from very common (>1/10 treatments) to very rare (<1/10,000 treatments).

      The investigators will then examine for differences between patient-reported and
      clinician-reported incidences and also explore for any correlations between adverse events
      and other various reported factors.
    

Intervention name(s): Observational dry needle
Intervention type(s): Other
Intervention description(s): No intervention provided by the study. Observation of any adverse events that occur surrounding dry needling by a physical therapist.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Any patient receiving DN as a regular part of their physical therapy care for any
        diagnosis.
      
Keywords: dry needling; adverse event; physical therapy