bioihbjkbjnl/mcl2 huggingface dataset:
REBT Intervention Program for Career Decision-making Difficulties in High School Pupils
Condition: Career Decision-making Difficulties; Worry; Psychological Distress
Study type: Interventional

Summary: 
      Career decision-making difficulties are frequent problems for adolescents. Regular
      intervention or prevention programs mainly provide information for the students about
      themselves, about the world of work, about their interests and preferences etc. Rational
      emotive behavioral therapy (REBT), a form of Cognitive behavioral therapy (CBT) provides help
      for adolescents to efficiently cope with emotional problems (e.g., psychological distress)
      related to the career decision-making process. The present study aims to investigate the
      efficiency of an REBT career intervention program implemented in a school setting. School
      settings are appropriate to deliver group intervention for students. Classes from Romanian
      public high-schools will be randomized in either intervention or treatment as usual groups.
    

Detailed description: 
      The intervention will be group based, delivered in 8 sessions, over 8 weeks. Each of the
      eight modules aimed a different component: Psychoeducation, Information about self and world
      of work, Steps of career decision-making, Problem solving. Additionally, for the REBT groups:
      Relationship between cognitive distortions/irrational beliefs and emotions, Cognitive
      restructuring, Exposure/behavioral activation and emotional problem solving, Maintenance of
      gaining. Homework would be given at every session. REBT intervention programs delivered in
      school settings represent ecological modalities to target vulnerable groups. Adolescents will
      complete assessments at four time points: T1 (baseline), T2 (post-intervention), T3 (3 months
      follow-up) and T4 (6 months follow-up).
    

Intervention name(s): REBT Career Intervention; Regular Career Intervention
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Eight sessions of regular career intervention with rational emotive behavioral therapy (REBT) methods.; Eight sessions of regular career intervention.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: career indecision; career decision-making difficulties; worry; psychological distress
Comparison of Two Tests in the Assessment of the Accuracy of Esophageal Pressure Variations Measurement During Mechanical Ventilation
Condition: Esophageal Pressure Measurement
Study type: Observational

Summary: 
      Esophageal pressure measurement, obtained with the use of an esophageal balloon catheter, is
      fundamental to assess mechanical characteristics of the respiratory system during mechanical
      ventilation. The correct positioning of the catheter (usually at the medium third of the
      esophagus) is crucial for an accurate measurement of esophageal pressure. Usually the correct
      positioning of the catheter is verified with an occlusion test (If the patient is breathing
      spontaneously) or with thoraco-abdominal compressions (if the patient is sedated and
      paralyzed). Aim of this study is to compare the accuracy of these two methods at different
      PEEP and esophageal catheter positions.
    


Intervention name(s): Occlusion test; Thoraco-abdominal compressions
Intervention type(s): Other; Other
Intervention description(s): Occlusion test to assess the correct positioning of esophageal balloon catheter when the patient is breathing spontaneously.; Thoraco-abdominal compressions to assess the correct positioning of esophageal balloon catheter when the patient is sedated and paralyzed.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients admitted to ICU after surgery treated with mechanical ventilation
      
Keywords: Esophageal pressure, Mechanical ventilation
Impact of Periodontal Bacteria at Baseline on the Effectiveness of Periodontal Therapy
Condition: Periodontitis
MeSH terms: Periodontitis
Study type: Interventional

Summary: 
      In light of the controversy that are already approved but that however still exists regarding
      the efficacy and influence of the protocols for the management of Periodontitis, the aim of
      this study was to evaluate, at 6 months follow-up, the post-treatment clinical parameters and
      immunological and gingival microbial profiles in patients with periodontitis, treated by
      either SRP in addition to full mouth scaling or quadrant scaling
    

Detailed description: 
      This trial was conducted in accordance with the World Medical Association's Declaration of
      Helsinki of 1975, and reviewed in 2008. The local ethical committee of the University of
      Messina approved the study protocol and each patient was carefully informed about the
      possible inherent risks of the study and provided their informed written consent 102
      patients, , aged 27 to 65 (mean age 44.2) were assessed for eligibility. In all subjects,
      subgingival plaque was acquired from 4 separate proximal sites at 180 days after therapy.
    

Intervention name(s): Scaling and root planing
Intervention type(s): Procedure
Intervention description(s): Full mouth or quadrant SRP
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
The Whole Body Vibration for Sarcopenic Hospitalized Patients Aged 80+ Years
Condition: Sarcopenia
MeSH terms: Sarcopenia
Study type: Interventional

Summary: 
      Resistance training have been recommended for sarcopenic patients. However, the whole body
      vibration training would further benefit for sarcopenic patients on the basis of resistance
      training remains unclear. The purpose of this study is to explore the effect of the whole
      body vibration training on improving the mobility of elderly patients with sarcopenia. The
      whole body vibration involves different frequencies that can improve muscle strength and keep
      aged upright, including the legs and core. These kinds of exercises can improve stability and
      help prevent falls.
    


Intervention name(s): the whole body vibration; resistance training
Intervention type(s): Behavioral; Behavioral
Intervention description(s): most people stand on the platform with knees bent at about a 30-degree angle, while the surface beneath their feet vibrates an astounding 30 times per second.; Resistance training is a form of exercise that improves muscular strength and endurance. During a resistance training workout, you move your limbs against resistance provided by your body weight, gravity,bands, weighted bars or dumbbells.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Avdoralimab an Anti-C5aR Antibody, in Patients With COVID-19 Severe Pneumonia ( FORCE )
Condition: COVID
MeSH terms: Pneumonia
Study type: Interventional
Phase: Phase 2

Summary: 
      The primary objective of this trial is to improve the proportion of COVID-19 patients with
      severe pneumonia who no longer need to be hospitalized, and to reduce the need for and
      duration of mechanical ventilation in patients with COVID-19 pneumonia complicated by acute
      respiratory distress syndrome (ARDS).
    


Intervention name(s): avdoralimab; Placebo
Intervention type(s): Biological; Other
Intervention description(s): intravenous administration of avdoralimab; intravenous administration of placebo
Other intervention name(s): IPH5401
Intervention MeSH terms: Avdoralimab
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Home Pregnancy Test Evaluation Study
Condition: Pregnancy Testing
Study type: Interventional

Summary: 
      This study will evaluate consumer preference and consumer results from a number of
      commercially available home pregnancy tests.

      The study is being conducted as a formal assessment home pregnancy tests sold in Western
      Europe.
    

Detailed description: 
      The study will be conducted in two parts:

      Part 1: Volunteers representative of pregnancy test users will use a range (4 of 7 different
      tests being evaluated) in their own home to gain usability data. All products will be used
      according to their instructions for use which, where required, will be translated into
      English prior to the study start. A study questionnaire will be completed after each test is
      used.

      Part 2: The volunteers will attend the study site soon after completing their last home test
      and be required to read randomised results of tests conducted by study technicians (pregnant
      and not pregnant) to gain an understanding of their ability to correctly read results of the
      tests. The technician will also read and record the test results to enable both the
      laboratory agreement (technician read) and the consumer readability to be determined and
      compared for each product.

      Each volunteer will be required to provide a urine sample for determining pregnancy status
      and quantitative urinary hormone measurement (this is done to confirm the result obtained at
      home using the HPTs).

      At the end of the testing period the volunteers will also be asked to rank the four products
      they have used in the study, based on a series of statements regarding usability and
      readability of the tests
    

Intervention name(s): home pregnancy test
Intervention type(s): Diagnostic Test
Intervention description(s): Each participant will use 4 different home pregnancy tests
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Effect of Pulsing Electrical Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study
Condition: Diabetic Peripheral Neuropathy
MeSH terms: Peripheral Nervous System Diseases; Diabetic Neuropathies
Study type: Interventional
Phase: Phase 4

Summary: 
      To determine if pulsed electric field therapy reduces lower leg and foot pain associated with
      diabetic neuropathy and lessens the need for medication.

      The MedRelief device sends a sub-threshold electric signal through the skin using electrodes
      as means of signal delivery. The signal or waveform, frequency and strength were created to
      match the characteristics of signals the body generates to help natural healing.
    

Detailed description: 
      A multi-center, randomized, open-label study involving 23 patients with chronic diabetic
      peripheral neuropathy meeting study entry criteria. Subjects will be randomly assigned to
      receive one of two treatments using an FDA cleared MedRelief device: (1) a MedRelief SE 55
      device set on "pulsed" mode at 10 microsecond burst intervals 4150 Ha, or (2) a MedRelief SE
      55 device set on "continuous" mode at 4150 Hz. Subjects will wear the device on target foot
      each night for a minimum of 6 hours over a two week (15 day treatment)period.

      Subjects will complete a daily pain diary, medication form, and device use form. Subject
      global assessments and physician global assessments will occur at baseline, study visits Day
      7, Day 15 and Day 21 (end of study).

      Response to therapy will include pain reduction, improvement in sensation, improved response
      to vibratory stimulation and reduction of edema in study subjects.
    

Intervention name(s): MedRelief SE 55
Intervention type(s): Device
Intervention description(s): 4150 Hz signal continuous or pulse, high intensity, high modulation for 6 hours each night during treatment phase
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: diabetes mellitus; neuropathy; distal symmetric polyneuropathy; pulsed electric fild
The Effect of Screen Time on Recovery From Concussion
Condition: Concussion, Brain
MeSH terms: Brain Concussion
Study type: Interventional

Summary: 
      This study will prospectively examine the effect of screen time on recovery from concussion.
      Patients 12 to 25 years of age presenting to the ED with a concussion will be randomized to
      allow for screen time as tolerated or to abstain from screen time for the first 48 hours of
      recovery. The amount of screen time use and duration of concussive symptoms will be assessed
      through daily surveys and a daily post-concussive symptom score (PCSS).
    


Intervention name(s): Screen time permitted; Screen Time Abstain
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Cohort will not be directed to abstain from screen time; Cohort will be directed to abstain from screen time
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: screen time
Lot-to-lot Consistency of Tritanrix™-HepB/Hib-MenAC & Its Non-inferiority vs Tritanrix™-HepB/Hiberix™ in Infants
Condition: Tetanus; Hepatitis B; Haemophilus Influenzae Type b; Whole Cell Pertussis; Diphtheria
MeSH terms: Hepatitis B; Whooping Cough; Tetanus; Diphtheria; Hepatitis
Study type: Interventional
Phase: Phase 3

Summary: 
      The primary purpose of this study is to demonstrate the lot-to-lot consistency of 3
      production lots of GSK Biologicals' Hib-MenAC (Haemophilus influenzae type b and
      meningococcal serogroups A and C) vaccine when reconstituted with Tritanrix™-HepB
      (diphtheria, tetanus, pertussis, and hepatitis B) vaccine and administered as a single
      injection.
    

Detailed description: 
      The study is double blind. However the active control vaccine Tritanrix™-HepB/Hiberix™ will
      be administered in a single-blind manner. Blood samples will be collected for immunogenicity
      analyses. GSK Biologicals' OPV vaccine will be administered concomitantly with the study
      vaccines at 2, 4 and 6 months of age according to local country regulation. The study will
      last approximately 5 months per subject
    

Intervention name(s): Hib-MenAC mixed with Tritanrix™-HepB
Intervention type(s): Biological
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single
Primary purpose: Prevention
Keywords: Haemophilus influenzae type b; diphtheria; tetanus; Prophylaxis diphtheria; pertussis; hepatitis B; meningococcal serogroups A & C diseases
Study of Dupilumab and Immune Responses in Adults With Atopic Dermatitis (AD)
Condition: Atopic Dermatitis
MeSH terms: Dermatitis, Atopic; Dermatitis; Eczema
Study type: Interventional
Phase: Phase 2

Summary: 
      This was a 32-week, randomized, double-blind, placebo-controlled, parallel-group study
      assessing immunization responses to vaccination in adults with moderate to severe atopic
      dermatitis who are treated with subcutaneous dupilumab.
    


Intervention name(s): Dupilumab; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Administered via subcutaneous injection.; An inactive substance containing no medicine administered via subcutaneous injection.
Other intervention name(s): REGN668; SAR231893; Dupixent
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Novel MRI Sequence- MR Fingerprinting
Condition: Disease
Study type: Interventional

Summary: 
      Magnetic Resonance Imaging (MRI) has become one of most important medical imaging tools over
      the past 30 years because it is non-invasive, requires no ionizing radiation, and provides
      exquisite images of soft tissues and anatomic structures with many tissue/disease specific
      contrasts. While MRI has served the community well for many years, it is increasingly clear
      that it also has significant limitations.

      One of the principle limitations is the lack of quantitative information for tissue/structure
      characterization. The current paradigm of MRI is to use a set of scanner settings to generate
      an image "weighted" by a specific MR contrast mechanism (physical parameter), where it is
      hoped that variations in the parameter will be accentuated. However, without quantitative
      knowledge of the parameters, the final image contrast may depend on many factors, which
      complicates image interpretation and diagnostic performance. Quantitative measurement can
      provide a great deal of information about tissue properties and pathological conditions,
      since these parameters ultimately determine the contrast that is observed in conventional
      images.
    

Detailed description: 
      The purpose of this study is to evaluate novel quantitative MRI techniques in clinical
      studies to determine whether they can provide better, faster and more useful information for
      clinical diagnosis. In this study, the investigators propose to apply MR Fingerprinting and
      evaluate its performance for different diseases. These include, but are not limited to,
      diseases in the liver, kidney, cardiac, pancreas etc. The investigators hypothesize that the
      quantitative MR Fingerprinting imaging technique will lead to improved tissue
      characterization and diagnosis.
    

Intervention name(s): MR Fingerprinting
Intervention type(s): Device
Intervention description(s): The MR fingerprinting technique requires less than 15 minutes and will be added following the standard MRI sequence.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Prevention of Acute Mountain Sickness by Intermittent Hypoxia
Condition: Acute Mountain Sickness
MeSH terms: Altitude Sickness; Hypoxia
Study type: Interventional

Summary: 
      Acclimatization by mountaineering prior to high altitude sojourns have shown to be effective
      in prevention of acute mountain sickness (AMS).

      The aim of this study is to investigate whether intermittent exposure to normobaric hypoxia
      during sleep is also effective to prevent AMS.
    


Intervention name(s): Hypoxic Exposure
Intervention type(s): Other
Intervention description(s): Sleeping in normobaric hypoxia for 14 nights at altitudes from 2500 - 3300 m prior to one night at 4500 m
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Prevention
Keywords: acute mountain sickness; intermittent hypoxia; acclimatization
Estimating Apnea Phenotypes From Polysomnography: Oxygen
Condition: Sleep Apnea
MeSH terms: Apnea
Study type: Interventional

Summary: 
      This study seeks to employ advanced methods to estimate the individual factors contributing
      to sleep apnea from standard recordings made during routine clinical sleep studies. This
      study focuses on breathing control or "loop gain" as one of the factors contributing to sleep
      apnea. Increased levels of oxygen in the air is known to make breathing more stable by
      lowering "loop gain". Here, our goal is to use a new method capable of detecting a reduction
      in loop gain with oxygen. The investigators also aim to test whether a high loop gain
      measured at baseline/placebo predicts a greater improvement in sleep apnea with oxygen
      therapy.
    

Detailed description: 
      In a single-blinded randomized crossover study, inspired oxygen/air (40%/21%) is delivered on
      two separate nights. Loop gain is measured from routine polysomnography using a novel
      mathematical method. A value of loop gain >1 reflects unstable breathing, and a value less
      than but approaching 1 denotes a system more prone to oscillate. Loop gain is measured as the
      changes in ventilatory drive/effort that arises subsequent to changes in ventilation (e.g.
      due to obstructive apnea). A simple chemoreflex model (gain, time constant, delay) is fit to
      surrogate ventilation data (derived from airflow) during sleep. The best model is one that
      best matches the elevated ventilatory drive (measured as ventilation in the absence of
      airflow obstruction) based on the prior apneic/hypopneic fall in ventilation. Loop gain is
      calculated from this model. We aim to use loop gain measured on and off oxygen to determine
      whether a strong response (reduction in apnea severity) can be predicted by a higher loop
      gain (in the sham arm) using our method. We also assessed whether assessing upper airway
      anatomy/collapsibility, dilator muscle responsiveness, and the arousal threshold helped to
      predict responses to treatment.
    

Intervention name(s): Inspired oxygen (40%); Sham
Intervention type(s): Drug; Other
Intervention description(s): Supplemental oxygen at 40% inspired via venturi mask (15 L/min). Equivalent to 5 L/min via nasal cannula.; Medical air with 21% oxygen via venturi mask (15 L/min).
Other intervention name(s): Supplemental oxygen; Medical air
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Treatment