Non Invasive Mechanical Ventilation Versus Respiratory Rehabilitation in Hypercapnic COPD
Condition: Lung, Hyperlucent; Positive-Pressure Respiration, Intrinsic
MeSH terms: Positive-Pressure Respiration, Intrinsic; Lung, Hyperlucent
Study type: Interventional
Phase: Phase 4

Summary: 
      Objective: To analyze the additional benefits of exercise training application by the
      non-invasive home mechanical ventilation in patients with stable COPD and hypercapnic
      respiratory failure. SUBJECT: moderate-severe COPD (FEV1 <60%) in chronic respiratory failure
      (hypoxemia and hypercapnia PaCO2> 45mmHg). GROUPS: 45 patients included prospectively and
      randomly into 3 groups of 15: a) training + NIPPV group, b) Group training, c) Group NIPPV.
      Hypothesis: A training program to the effort associated with treatment with NIPPV
      significantly increase the effects compared with each treatment. MAIN OBJETIVE: Effects on
      exercise capacity as measured by the test of endurance cycling and test 6-minute walk
      (distance). SECONDARY OBJECTIVES: Impact on quality of life and dyspnea, as measured by
      questionnaire and CRQ, systemic inflammatory response (CRP, IL-8, TNF-α), changes in
      peripheral muscle strength (1RM test, isometric) and effects score BODE index.
    

Detailed description: 
      1. POPULATION: Patients with COPD diagnosed according to criteria established by the ATS
           (American Thoracic Society) and the SEPAR (Spanish Society of Pneumology and Thoracic
           Surgery) to submit a modereda-severe obstruction to airflow (FEV1 <60%) and a clinical
           impact of their disease. Patients must have chronic respiratory failure with hypoxemia
           and hypercapnia (PaCO2> 45 mmHg). Patients should be stable and appropriate therapy.

        2. SAMPLE: 45 patients diagnosed at the Department of Pulmonology, Hospital Virgen del
           Rocío de Sevilla, informed consent.

        3. EXCLUSION CRITERIA a. Other cardiorespiratory diseases. b. Systemic diseases c.
           Disability or discomfort to participate in an exercise program or noninvasive
           ventilation

        4. STUDY GROUP: The patients were prospectively included and randomized to one of three
           groups of 15 patients:

             -  Group exercise training program of positive pressure ventilation and noninvasive.

             -  Group exercise training program.

             -  Group program Ventilation Noninvasive positive pressure.

        5. Variables: All patients underwent the following baseline tests:

           • CXR, elementary analysis, 12-lead electrocardiogram

           • simple spirometry and bronchodilator test

           • Blood gases

             -  static lung volumes (FRC, RV, TLC) by plethysmography.

             -  Study of diffusion (DLCO) by single breath technique

             -  maximum muscle pressures both inspiratory and expiratory.

             -  Estimation of muscle strength:

                a. Repetition maximum test (Test 1 RM) b. Maximum isometric quadriceps strength and
                biceps measured with dynamometer (MIE Myometer ltd. With CAS software) c.
                Determination of muscular fatigue in the isometric tests of quadriceps and biceps,
                with the same system dynamometer (MIE Myometer ltd., Software CAS)

             -  Stress Test:

                a. Maximum, with cycle ergometer and methodology already known, including:
                Determining, from the respiratory gases, oxygen consumption, carbon production and
                indirect anaerobic threshold, breathing pattern (minute ventilation, tidal volume,
                respiratory rate) , electrocardiography and pulse oximetry during exercise with
                heart rate control, blood pressure and dyspnea Borg scale.

                b. Submaximal cycle ergometer resistance with 70% of the load reached the ultimate
                test, with essentially control the resistance time, distance walked, and control of
                saturation (pulse oximetry) and heart rate achieved.

                c. Shuttle walking test, walk test is performed continuously walk between two
                points separated 10 meters and control the pace of a hearing.

             -  Assessment of dyspnea and quality of life:

                  1. Baseline dyspnea index and index of transitional measures functional
                     impairment, magnitude of the task and the magnitude of effort (Test of
                     Mahler).

                  2. Assessment of quality of life based on the specific questionnaire (CRQ)
                     proposed by Guyatt for COPD patients and modified for your understanding in
                     Spanish-speaking subjects.

        6. STUDY DESIGN:

      The training program (trained group) was carried out for 12 weeks and sessions of 40 minutes
      duration:

        1. 20 minutes of bicycle ergometer with an initial charge of about 70% of initial maximal
           oxygen consumption, increasing the load every two weeks as tolerated.

        2. Weightlifting in 2 sets of 6 replicates of 5 simple exercises. These are held at a
           station multigimnástica (CLASSIC Fitness Center, KETTLER) and are:

             1. Simple bending of the arms (pull cable to the chest "Chest pulls"): effects on the
                latissimus dorsi, deltoids and biceps. Procedure: Sitting in the face of the tower
                of strength, approaching the bar to the chest and arm span later after return to
                the starting position.

             2. Simple extension of the arms (force to the neck "Neck press / shoulder press):
                Effects on the deltoids and triceps. Procedure: Sitting upright on the bench and
                held the weight to shoulder height, arm span will be held over his head, slowly
                returning after bending arms to starting position.

             3. Arm flexion and extension against resistance (Butterfly "Butterfly"): Effects on
                the pectoral and deltoid muscles. Sitting upright on the bench with your forearms
                and elbows on a lever, takes it to the midline, giving way slowly to the starting
                position.

             4. Leg extensions ("Leg extension"): Effects on quadriceps. Sitting on the bench leg
                extension is performed against resistance.

             5. Leg Curl ("Leg curls): Effects on femoral biceps and calves. Lying prone on the
                bench legs are flexed against the weight.

                Resistance is increased gradually from 50% of the maximum weight you can lift the
                patient on one occasion, early in the week, up to 85%. Every two weeks the weight
                limit is reassessed to adjust the training load in each patient (Test 1 RM).

                The groups that come under the non-invasive ventilation program will do so for 12
                weeks. Noninvasive ventilation was initiated with support pressure applied with a
                bilevel positive pressure ventilator (BiPAP ® Respironics, Inc.) This is a
                ventilatory support system that maintains pressure at two different levels, a level
                of positive expiratory pressure, or EPAP ( equivalent to conventional mechanical
                ventilation PEEP) and a positive inspiratory pressure (IPAP, equivalent to pressure
                support), even in the presence of flow variations.

                The device can be programmed in different modes. In the spontaneous (S), the system
                cycles to EPAP to IPAP when the patient's inspiratory flow exceeds 40 ml / sec.
                over 30 msec. IPAP level is maintained for more than 180 milliseconds and cycles to
                EPAP when inspiratory flow falls below a certain level, when it detects an
                expiratory effort or the IPAP is held for more than 3 seconds. Thus, the patient
                retains control over the respiratory rate, inspiratory flow and time. T mode, the
                system provides the patient ventilatory support to a programmable frequency without
                detecting any inspiratory effort (similar to a controlled manner in the
                conventional mechanical ventilation). ST mode would be intermediate between them
                and equivalent to assist-control ventilation in a volume ventilator.

                The NIV will be implemented initially through a nasal mask (Respironics) with a
                size appropriate to the patient, fixed by elastic belts fastened with Velcro, and
                with sufficient strength to prevent escape but while avoiding excessive pressure in
                order to achieve maximum comfort the patient. If leaks are important in the mouth
                that hindered the NIV, is replaced by an oronasal mask (Respironics).

                The first set parameters are: IPAP 10 cm H2O, EPAP 4 cm H2O, and ST mode, setting a
                respiratory rate of 12 breaths per minute. The IPAP was progressively increased to
                a maximum of 20 cm H2O, depending on patient tolerability, clinical response and
                arterial oxygen saturation by pulse oximetry continuously monitored, trying to
                avoid possible leaks through the mask.It can also supply oxygen through a tube
                connected to the mask at a rate of 2-4 liters per minute in order to maintain
                oxygen saturation at around 85-90%.

                Patients were ventilated continuously during the night hours (minimum between 6-8
                hours per night).

                Upon completion of 12 weeks of treatment applied according to each study group, all
                tests were repeated at baseline and compared the results.

           7. EXIT CRITERIA STUDY:

             -  Offset of the patient.

             -  Loss of 3 or 5 consecutive sessions staple.

             -  On the initiative of the patient.

                8. Statistical analysis:

           Analyzing the effect size at the expense of an improvement in work reached about 15 W
           higher than the stress test, assuming a standard deviation of this parameter of + / -
           10W, An alpha of 0.05 and a beta of 0, 1 (statistical power 90%) and calculating a loss
           ratio of 15%, we estimate a sample size of 15 patients for each group.

           Comparing before and after the training response in each group were performed using a
           paired t test. Comparisons between groups were made using analysis of variance (ANOVA).
           The Pearson correlation coefficient and linear regression analysis will allow to examine
           relationships between physiological variables. Be considered significant at p <0.05. The
           dispersion of a mean value is expressed as mean + / - standard deviation.
    

Intervention name(s): ventilation; excecise training; Both
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): positive-pressure breathing bilevel (BiPAP ® Respironics, Inc.) Parameters initially programmed be: IPAP 10 cm H2O, EPAP 4 cmH2O, method ST setting yourself respirations 12 breaths minute. The IPAP was progressively increased to a maximum of 20 cm H2O, depending on patient tolerability, clinical response and arterial oxygen saturation was continuously monitored by pulse oximetry, trying to avoid possible leaks through the mask. It can also supply oxygen through a cannula connected to the mask at a flow rate of 2-4 liters per minute to maintain oxygen saturation at around 85-90%.
Patients aired uninterruptedly during nighttime (minimal between 6-8 hours night).; The training program (trained group) was carried out for 12 weeks and sessions of 40 minutes duration:
20 minutes of bicycle ergometer with an initial charge of about 70% of initial maximal oxygen consumption, increasing the load every two weeks as tolerated.
Weightlifting in 2 sets of 6 replicates of 5 simple exercises. These are held at a station multigimnástica (CLASSIC Fitness Center, KETTLER); both types of intervention
Other intervention name(s): Non invasive positive ventilation; pulmonary rehabilitation; ventilation and exercise
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: COPD; Exercise trainig