Omega-3 on Lipid Profile and Serum Leptin Level n Neonates With Intrauterine Growth Restriction
Condition: Lipid Profile; Neonates; Intrauterine Growth Restriction
MeSH terms: Fetal Growth Retardation
Study type: Interventional

Summary: 
      The aim of our study will demonstrate the effect of omega 3 supplementation on serum lipid
      profile level and leptin level in neonates with Intrauterine Growth Restriction( IUGR)
    

Detailed description: 
      Intrauterine growth restriction is a major cause of perinatal mortality and morbidity .

      It is noted to affect approximately 5-15 % of pregnant women. Egypt has one of the highest
      incidences of Intrauterine Growth Restriction. The incidence of IUGR varies among countries,
      populations, races and increases with decreasing gestational age. 14 to 20 million infants
      have been affected with Intrauterine Growth Restriction cases in the developing countries
      annually.

      A complex and dynamic interaction of maternal, placental and fetal environment is involved in
      ensuring normal fetal growth. An imbalance or lack of coordination in this complex system may
      lead to Intrauterine Growth Restriction. Intrauterine Growth Restriction( IUGR) results in
      significant perinatal and long-term complications, including increased neonatal mortality and
      morbidity and higher risk for developing metabolic syndrome later in life.

      Physiological differences have been noted in growth restricted infants. Intrauterine amino
      acid disturbances similar to biochemical changes seen in postnatal protein deprived states
      have been detected. Protein metabolism defect and altered lipid metabolism also have been
      described.

      Undernourishment in utero appears to be associated with persisting changes in the metabolic
      functions. Birth weight influences the lipoprotein profile and cholesteryl ester transfer
      protein, which promotes a proatherogenic lipoprotein profile in plasma by determining
      chemical, physical and biological properties of the respective lipoprotein particle in
      neonates.

      Recent research suggests that several of major disease of later life, including coronary
      heart disease, hypertension & type II diabetes originate in impaired intrauterine growth and
      development. These diseases may be consequence of programming whereby a stimulus or insult at
      a critical, sensitive period of early life has a permanent effect on structure, physiology
      and metabolism.
    

Intervention name(s): Omega-3 supplement group; Full feeding without receiving any supplementation group
Intervention type(s): Dietary Supplement; Other
Intervention description(s): 35 Neonates were given Omega 3 in a dose of 40mg/kg/day (8), after establishment of full-feeding and for 2 weeks duration. Omega-300 (Montana pharmaceutical industry) capsule was used which contains 1000mg Omega 3 fatty acids.; 35 full term Growth Restriction( IUGR) neonates who were followed up to full feeding without receiving any supplementation.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment