bioihbjkbjnl/mcl2 huggingface dataset:
Pericoronary Fat Attenuation Index and High-risk Plaque in Patients With Acute Coronary Syndrome
Condition: Acute Coronary Syndrome
MeSH terms: Acute Coronary Syndrome; Syndrome
Study type: Observational

Summary: 
      This study aimed to investigate the relationship between CCTA-based pericoronary inflammation
      and plaque features as well as local immune-inflammatory biomarkers in ACS patients. It is
      hypothesized that perivascular FAI might serve as a reliable sensor of coronary
      immune-inflammatory disorder, and closely related to the plaque vulnerability.
    

Detailed description: 
      The pericoronary fat attenuation index (FAI), which capture by standard coronary computed
      tomography angiography (CCTA), has emerged as a novel imaging biomarker of coronary
      inflammation. This study aimed to assess whether increased Pericoronary FAI on CCTA are
      associated with high-risk plaque (HRP) feature as well as local T cell subsets and their
      intracellular cytokines levels in non-ST elevation acute coronary syndromes ( ACS) patients.
      195 lesions in 130 non-ST elevation ACS patients were prospectively enrolled and evaluated by
      CCTA and coronary angiography in this study. Blood were taken from coronary artery
      immediately after the diagnostic angiogram. Local T cell subsets and their intracellular
      cytokines levels were detected by Flow Cytometry. CCTA and pericoronary FAI examinations were
      performed using a 320-detecor (Aquilion ONE, Toshiba Medical Systems, Otawara, Japan)
      Systems. Coronary plaque characteristics were analyzed cross each of the main coronary
      arteries using commercialized software package (Qangio CT, Medis, The Netherlands).
    

Intervention name(s): HRP frequency, plaque compostion and local immune-inflammatory activation
Intervention type(s): Diagnostic Test
Intervention description(s): HRP frequency, plaque compostion were detected by CCTA method. Local T cell subsets and their intracellular cytokines levels were detected by Flow Cytometry.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Between January 2019 and January 2020, a total of 130 patients with 195 lesions were
        included in our study for final analysis.
      
Keywords: pericoronary fat attenuation index; high-risk plaque
A Long-Term, Placebo-Controlled X-Ray Study Investigating the Safety and Efficacy of SD-6010 in Subjects With Osteoarthritis of the Knee
Condition: Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional
Phase: Phase 2

Summary: 
      The objective of this 2-year study is to evaluate the safety, tolerability and disease
      modifying efficacy of SD 6010, an inhibitor of inducible nitric oxide synthase (iNOS), in
      overweight and obese subjects with knee osteoarthritis. The efficacy of SD-6010 will be
      evaluated by radiography using joint space narrowing in the medial tibiofemoral compartment
      of the study knee as the primary endpoint.
    


Intervention name(s): SD-6010; SD-6010; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 200 mg tablets once a day for 2 years; 50 mg tablets once a day for 2 years; Placebo tablets once a day for 2 years
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: knee Osteoarthritis Disease Modifying Osteoarthritis Drug
The Effect of Food Supplements on Food Intake and Gut Hormone Levels
Condition: Obesity; Endocrine; Obesity; Appetite; Perverted
MeSH terms: Obesity
Study type: Interventional

Summary: 
      When a meal is eaten, nutrients activate the release of hormones from the bowel into the
      blood stream. Normally there is a large amount of hormone released, which tells the brain
      that an individual is full and to stop eating. When people gain weight and become overweight
      or obese, these hormone signals are reduced, resulting in these people eating more and
      gaining more weight. This study is investigating mechanisms which may break this cycle by
      using particular nutrients to restore reduced hormone levels.
    


Intervention name(s): Lauric Acid, Perilla Oil and Diindolylmethane
Intervention type(s): Dietary Supplement
Intervention description(s): Colonic release capsules containing lauric acid (2400mg), perilla oil (2100mg) and diinodlylmethane (500mg) given to volunteers 1 hour prior to standardised breakfast and lunch meal. Placebo group given cellulose capsules of same volume prior to standardised breakfast and lunch meal.
Intervention MeSH terms: 3,3'-diindolylmethane; Perilla seed oil
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Double blinded, randomised, crossover, placebo controlled.
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Nutrient; Anorexigenic hormone; Calorific Intake
Effectiveness of a Ready-to-Use-Food (RUF) Supplement to Prevent Acute Child Malnutrition
Condition: Child; Malnutrition
MeSH terms: Malnutrition
Study type: Interventional
Phase: Phase 4

Summary: 
      The overall objective of this project is to assess the effectiveness and cost-effectiveness
      of RUF (ready-to-Use Food, Plumpy Doz(r)) to prevent moderate acute malnutrition in children
      aged 6-36 months if embedded in a program of conditional household food assistance.
    


Intervention name(s): Plumpy Doz(r) - Ready-to-Use Food; Food-for-Training
Intervention type(s): Dietary Supplement; Behavioral
Intervention description(s): 47g Plumpy Doz(r) per day per child; Conditional family food supplementation (sugar, sorghum, beans, iodized salt, vegetable oil) 1800 kcal/person/day in function of attendance and participation in a sensitization program covering various themes on household, water and disease management, hygiene promotion, sanitation and dietary practices for children.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: moderate acute malnutrition, prevention, Lipid-based supplement
A Second Dose of Measles Vaccine (MV) in the Second Year of Life
Condition: Child Mortality; Child Morbidity
MeSH terms: Measles
Study type: Interventional

Summary: 
      This study evaluates the non-specific effects on child mortality and morbidity of a second
      dose of measles in the second year of life. Half of the study participants will receive a
      second dose of measles vaccine at 18 months of age while the other half will receive a second
      dose of measles by 4 years of age or at the end of the study.
    


Intervention name(s): Measles vaccine
Intervention type(s): Biological
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Bioavailability of Combination Tablet BI 1356/Metformin Compared With Single BI 1356 and Metformin Administered Together to Healthy Male and Female Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The objective was to assess the relative bioavailability of a pilot scale linagliptin 2.5 mg
      / metformin 1000 mg fixed dose combination (FDC) tablet in comparison with single tablets of
      linagliptin 2.5 mg and metformin 1000 mg administered together.
    


Intervention name(s): BI 1356/metformin; BI 1356; Metformin
Intervention type(s): Drug; Drug; Drug
Intervention description(s): fixed dose combination tablet
Intervention MeSH terms: Metformin; Linagliptin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Three Combinations Of Docetaxel And Irinotecan For Recurrent Or Metastatic Non Small Cell Lung Cancer
Condition: Carcinoma, Non-Small-Cell Lung
MeSH terms: Carcinoma, Non-Small-Cell Lung
Study type: Interventional
Phase: Phase 2

Summary: 
      A multicenter randomized phase II study evaluating the activity and tolerability of three
      different combinations of docetaxel (taxotere) and irinotecan (campto) as second line therapy
      for recurrent or metastatic non small cell lung cancer (NSCLC)
    


Intervention name(s): Irinotecan; Docetaxel
Intervention type(s): Drug; Drug
Intervention MeSH terms: Docetaxel; Irinotecan
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Incidence of Short Sublingual Frenulum in Newborns at the Hospital Nostra Senyora de Meritxell.
Condition: Ankyloglossia
MeSH terms: Ankyloglossia
Study type: Observational

Summary: 
      The aim of the study was to analyze the incidence of short sublingual frenulum in newborns of
      the Hospital Nostra Senyora de Meritxell of the Principat of Andorra.
    

Detailed description: 
      Thus, the objective of this study was to determine the incidence of AG in newborns of the
      Hospital Nostra Senyora de Meritxell of the Principat of Andorra, as well as the relationship
      with auxological data, associated malformations or diseases and hereditary component of the
      newborn.

      A random sample of 2167 individuals is enough to estimate, with a confidence of 95% and an
      accuracy of +/- 1 percentage units, a population percentage that is projected to be around
      6%. The percentage of replenishment required is projected to be 0%. With this sample, it will
      be sufficient to estimate the children who have ankyloglossia, the % of relatives who also
      have it (a population percentage that is projected to be around 25%). Confidential and
      anonymous collection of data from patients' medical records for a period of 2 years and 8
      months, and write them down in a database to finally correlate them and see if there is any
      association with the parameters studied.
    

Intervention name(s): observacional
Intervention type(s): Other
Intervention description(s): Analyze the incidence of short sublingual frenulum in newborns of the Hospital Nostra Senyora de Meritxell of the Principat of Andorra.
Association or not of the AG with auxological parameters (weight, height, cranial perimeter) at birth.
Association or not of the AG with sex.
Association or not of the AG with gestational age.
Association or not of the AG with other minor and major malformations.
Observational model: Other
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        A random sample of 2167 individuals is enough to estimate, with a confidence of 95% and an
        accuracy of +/- 1 percentage units, a population percentage that is projected to be around
        6%. The percentage of replenishment required is projected to be 0%.
Transcranial Direct Current Stimulation (tDCS) and Cognitive Processing
Condition: Aphasia; Autism; Schizophrenia
MeSH terms: Aphasia; Schizophrenia
Study type: Observational

Summary: 
      This research is being done to determine whether transcranial direct current stimulation
      (tDCS) can improve certain mental abilities. In this research, battery powered device is used
      to deliver very weak electrical current to the surface of the scalp while participants
      complete cognitive tasks. Our aim is to find out whether tDCS will improve task performance
      in both healthy adults and those with neurological impairment.
    

Detailed description: 
      Participants enrolled into this study may be asked to do the following:

        -  Grant permission for the researchers to view medical records associated with their
           language/cognitive difficulties (if applicable.

        -  Complete a questionnaire, provide a health history, and take some pencil-and-paper tests
           of problem-solving and memory in order to verify eligibility to participate and to able
           to safely undergo the experimental procedures.

        -  Complete several tasks (i.e., saying words out loud, naming objects, drawing designs,
           remembering lists of words, searching for images or letters, and/or completing puzzles)
           based upon a number of cognitive functions such as language, memory, vision, processing,
           and perception.

        -  Wear electrodes that will be placed on the scalp with a large rubberized band. These
           electrodes will administer very weak electrical current (tDCS) from a battery powered
           device for 20 to 60 minutes.

        -  Participation in several study conditions. The exact conditions and their order will be
           randomized. Under some conditions, participants may receive active stimulation (tDCS)
           and under other conditions, they may receive sham stimulation.

        -  The experimental sessions will last approximately 2 hours and participants may be asked
           to have more than one testing session in a day or to return for additional sessions.

        -  Have a Magnetic Resonance Imaging (MRI) brain scan.
    

Intervention name(s): Transcranial Direct Current Stimulation (tDCS)
Intervention type(s): Procedure
Intervention description(s): Anodal, Cathodal or Sham tDCS.
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        You must also belong to one of three groups to join this study:

          1. Healthy adults with no known deficits in cognition

          2. Adults with acquired language problems (i.e., stroke, mental illness)

          3. Adults with developmental language delays
      
Keywords: Normal cognitive function; Aphasia; Autism; Schizophrenia
Safety and Immunogenicity of the LEISH-F2 + MPL-SE Vaccine With SSG for Patients With PKDL
Condition: Post Kala Azar Dermal Leishmaniasis
MeSH terms: Leishmaniasis; Leishmaniasis, Visceral
Study type: Interventional
Phase: Phase 1

Summary: 
      A phase 1, randomized, double-blind, placebo-controlled study to evaluate the safety,
      tolerability, and immunogenicity of three injections of 10 µg LEISH-F2 + 25 µg MPL-SE given
      at 14-day intervals as an adjunct to standard chemotherapy with sodium stibogluconate (20
      mg/kg/day for 40 days) in patients with PKDL.
    


Intervention name(s): LEISH-F2 + MPL-SE vaccine
Intervention type(s): Biological
Intervention description(s): LEISH-F2 protein (10 ug) + MPL-SE (25ug) Three injections, 14 days apart
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: PKDL
Practice of the Short Wave Diathermy (SWD) Application
Condition: Electromagnetic Fields
MeSH terms: Hyperthermia
Study type: Observational

Summary: 
      Various national & international bodies like FDA, CSP has laid down the guidelines for the
      reasonable use of SWD electro therapeutic agent (EPA) ensuring safety & effectiveness.

      However, it remains uncertain, whether the practicing physiotherapists are aware of the very
      existence of this guidelines and implementing them in daily practice. Any lack of knowledge
      about this background can endanger the patient safety leading to serious health hazards.

      In the present survey, 49 physiotherapy practitioners were interviewed with a self-report
      measure to investigate their knowledge base, mode of application of SWD (6 items) & the
      awareness about recommended guidelines (5 items) etc.
    

Detailed description: 
      Study design: cross sectional survey design with the use of a self-report form to record the
      participant's views was used. Sampling frame consisted of physiotherapists working in private
      clinics in sub-urban area of Mumbai, Maharashtra, India.

      Institutional ethic committee of Terna Physiotherapy College granted permission to conduct
      this survey. The self-report forms were coded in order to conceal the identity of the
      therapist.

      In this survey 49 physiotherapists were interviewed with a self-report form consisting of
      total 23 item. In the initial section of this survey form a general information was collected
      regarding years of experience (1 item), Types of condition treated (1 item), No of patients
      treated (item 1) Duration of onset (item 1) & the type of modality used (item 1). Specific
      items interrogating therapist's knowledge about the EMF generating modality were designed to
      retrieve the information about dosage prescription (7 item), acquaintance with recommended
      guidelines & indications (item 5), years of experience with that particular modality (item1),
      Any kind of side effects observed (item 1), any action taken for the same (item 2), referring
      personnel for recommending this modality (item 1), overall therapist's experience with the
      effectiveness of this modality (item1).
    

Intervention name(s): interview method: self report form
Intervention type(s): Other
Intervention description(s): the responses about participants perception, behavior pattern and attitude were recorded on the self report form
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        49 PRACTICING PHYSICAL THERAPIST IN PRIVATE CLINICS
      
Keywords: SWD, EPA, SAFE PRACTICE
Exercise and Post-dry Needling Soreness
Condition: Shoulder Pain
MeSH terms: Shoulder Pain
Study type: Interventional

Summary: 
      Application of trigger point dry needling can induce post-dry needling soreness. This is not
      a negative experience, but sometimes some patients want to reduce it as much as possible.
      Manual therapies and exercise strategies targeting to decrease post-dry needling soreness
      need to be investigated.
    


Intervention name(s): Eccentric Exercise; Detuned Ultrasound; Placebo
Intervention type(s): Other; Other; Other
Intervention description(s): Individuals will perform 3 sets of 10 repetitions of eccentric exercise of the infraspinatus muscle after the application of trigger point dry needling; Individuals will received 10 minutes of detuned ultrasound on the infraspinatus muscle after the application of trigger point dry needling; Individuals will not perform any action after the application of trigger point dry needling
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: trigger points; disability; post-dry needling soreness; eccentric exercise
Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies
Condition: Abnormal Vaginal Flora; Clindamycin Vs Metronidazole; High Risk Pregnancies for Preterm Labor
MeSH terms: Obstetric Labor, Premature
Study type: Interventional

Summary: 
      Abnormal vaginal flora is a risk factor for preterm labor. Therefore, in high risk
      pregnancies for preterm labor the diagnosis and treatment of abnormal flora is indicated.
      Clindamycin and metronidazole given orally are both acceptable treatments in these cases. The
      purpose of this study is to compare the effectiveness of Clindamycin Vs metronidazole for the
      treatment of abnormal vaginal flora in high risk pregnancies. For this purpose, pregnant
      women who are considered high risk for preterm labor and were diagnosed with abnormal vaginal
      flora will be randomly treated either with clindamycin or metronidazole. Eradication of the
      abnormal flora and adverse effects will be monitored and compared
    


Intervention name(s): Clindamycin; Metronidazole
Intervention type(s): Drug; Drug
Intervention description(s): Oral clindamycin 300 Milligrams*2/Day for a week; Oral metronidazole 500 Milligrams*2/Day for a week
Intervention MeSH terms: Metronidazole; Clindamycin; Clindamycin palmitate; Clindamycin phosphate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Abnormal vaginal flora; clindamycin Vs metronidazole; High risk pregnancies for preterm labor; Preterm labor; Late abortion; bacterial vaginosis
Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing
Condition: Periodontitis; Dental Caries; Hypertension
MeSH terms: Periodontitis; Dental Caries; Hypertension
Study type: Interventional
Phase: Phase 4

Summary: 
      The aim of this study is to determine the beneficial effect of mouth rinses, both topical
      analgesic and saline regimens as an adjuvant therapy in the presence of standard prescription
      of post-operative pain killers on the progress of socket healing following routine dental
      extraction.
    

Detailed description: 
      Hypertension is a highly prevalent cardiovascular disease, which affects over 1 billion
      people worldwide. It varies with age, race, education and so forth.1 The National Health
      Survey of Pakistan estimated that hypertension affects 18% of adults and 33% of adults are
      above 45 years old.2It is a common disease encountered in dental setting. Its wide spreading,
      terrible consequences, and life-long treatment require an attentive approach by dentists.
      Knowledge of hypertension is important for dentists especially for risk assessment for dental
      treatment. This may lead to improved monitoring and treatment.

      Dental treatment in hypertensive patients necessitates special attention, because any
      stressful procedure may increase blood pressure and trigger acute complications such as
      cardiac arrest or stroke. Extractions are usually done for teeth which are not salvageable.
      Dentists routinely advice use of warm saline rinses to help in healing of post extraction
      socket. But for hypertensive patients this recommendation is potentially harmful There is no
      evidence based guidelines on using saline rinses for post extraction oral care among
      hypertensives. Moreover, advantage of orally dissolved topical analgesics in addition to
      orally administered analgesic is questionable.
    

Intervention name(s): analgesic mouth rinses (dissolved Aspirin); Normal saline rinses.
Intervention type(s): Drug; Drug
Intervention description(s): Group 1 and Group 2 patients will be prescribed analgesic mouth rinses (dissolved Aspirin) twice daily along with the standard prescription of analgesics and antibiotics.; Non Hypertensive patients will be prescribed normal saline rinses twice daily along with the standard prescription of analgesics and antibiotics.
Other intervention name(s): water dissolved aspirin rinse; warm saline rinses; salt water rinses
Intervention MeSH terms: Aspirin; Analgesics
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: tooth extraction; tooth socket healing; hypertension; rinses