GraviD-child Follow-up of the Children´s Health, Growth and Development Within the GraviD-study
Condition: Vitamin D Deficiency; Body Composition; Vascular Health; Cardiometabolic Risk
MeSH terms: Vitamin D Deficiency
Study type: Observational

Summary: 
      GraviD is a multi-ethnic population-based pregnancy cohort. Pregnant women were invited to
      participate in the GraviD study when registering for antenatal care in parts of the region of
      Västra Götaland in Sweden in 2013-2014. All women registering for antenatal care were
      eligible for inclusion, as long as the pregnancy had not exceeded 16 gestational weeks. In
      total, 2125 pregnant women were recruited in gestational week 12 during two time-periods;
      fall 2013 and spring 2014. Blood sampling was performed in gestational week <17 and again at
      gestational week >31 by midwifes. After delivery, the maternity records were obtained, to
      collect information on child's gender, birth weight and length and other possible birth
      outcomes.
    

Detailed description: 
      In the GraviD-child study, all healthy singleton children born within the GraviD study will
      be invited to participate in a single clinical follow up. The follow-up will be conducted
      when all children are between 7-8 years of age. The study centre is located at the Queen
      Silvia Children´s hospital in Gothenburg, Sweden. The follow up consist of several parts:

        1. Measurement of body weight and height, and waist circumference.

        2. A questionnaire regarding health, physical activity, sleeping habits and diet.

        3. Endothelial function, a measure of how well the blood vessels dilute.

        4. Ultra sound of the thickness of the vessels on the neck, wrist and foot

        5. Pulse wave velocity, to measure the elasticity of the vessels on the neck and groin.

        6. Body composition using bioelectrical impedance.

        7. Blood pressure

        8. A venous blood sample of maximum 18 ml will be drawn to analyze markers of
           cardiovascular health. Blood lipids (total cholesterol, triglycerides, HDL cholesterol,
           LDL cholesterol), lipoprotein A, apolipoproteins (Apo A1 and Apo B), liver enzymes,
           glucose, insulin, HbA1c, c-reactive protein, leptin, adiponectin, nutritional biomarkers
           (such as 25-hydroxyvitamin D) will be analyzed.

      The study hypothesis is that a low maternal vitamin D status increase the risk of an
      unfavorable child cardiometabolic risk profile, vascular health and body composition.

      Recruitment start in January 2022 and will run for about a year.
    

Intervention name(s): Maternal vitamin D status
Intervention type(s): Other
Intervention description(s): Maternal vitamin D status (serum 25-hydroxyvitamin D) was collected during the GraviD study, while the woman was pregnant with the child now being followed-up in the GraviD-child study
Intervention MeSH terms: Vitamin D
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        All healthy singleton children born within the GraviD study
      
Biospecimen description: 
      Whole blood, serum, plasma