Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo
Condition: Nausea; Vomiting; Vertigo
MeSH terms: Vertigo; Nausea; Vomiting; Dizziness
Study type: Interventional
Phase: Phase 4

Summary: 
      -  Vertigo complaint is one of the common cause of patients who applied to emergency
           services.

        -  Patients who have applied to emergency services with vertigo complaint mostly have
           nausea as an additionally symptom to this complaint and anti-emetic agents can be used
           in their treatments very often.

        -  The investigators purpose is to investigate the advantages of Dimenhydrinate and
           metoclopramide to each other in the treatment of vertigo and the vertigo accompanied by
           nausea
    

Detailed description: 
      -  Vertigo describes the illusion of being subject to an involuntary movement, usually
           rotational, of the patient or the patient's surroundings which is caused by sudden tonic
           neural activity.

        -  The management and episodic treatment of patients with spontaneous vertigo related
           nausea-vomiting symptoms are somewhat controversial in the emergency department setting.

        -  Patients admitted to the emergency department with complaints of vertigo in addition to
           a large portion of the symptoms are accompanied by nausea and antiemetic agents are
           frequently used in the treatment.

        -  An ideal treatment should be rapid in onset and effective, and lack debilitating side
           effects.

        -  Although a wide variety of classes of pharmacologic agents and modalities are used, the
           emergency department treatment of acute spontaneous vertigo and associated with nausea-
           vomiting has not been well studied.

        -  It has been reported that the most commonly used medications for parenteral treatment of
           vertigo and nausea-vomiting in emergency department are dimenhydrinate (DMT) and
           metoclopramide (MTP).

        -  It has a depressant action on hyper-stimulated labyrinthine function and antiemetic
           effects, believed to be due to the antihistamine.

        -  Dimenhydrinate inhibits vomiting by affecting the histaminic receptor and cholinergic
           receptor function center of vestibular nucleus in the central vestibular system.

        -  Dimenhydrinate reduces the symptoms of vertigo with depressant effects on the labyrinth
           function by this means.
    

Intervention name(s): Dimenhydrinate; Metoclopramide
Intervention type(s): Drug; Drug
Intervention description(s): 50 mg Dramamine with 5 cc syringe in 150 ml normal saline given as a slow intravenous infusion over 15 minutes; 10 mg Metoclopramide with 5 cc syringe in 150 ml normal saline given as a slow intravenous infusion over 15 minutes
Other intervention name(s): Dramamine; Primperan; metpamid
Intervention MeSH terms: Metoclopramide; Dimenhydrinate
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Metoclopramide; Dimenhydrinate; emergency medicine