Impact of Poplar Propolis on Metabolic Disturbances of Insulin Resistance
Condition: Insulin Resistance
MeSH terms: Insulin Resistance
Study type: Interventional

Summary: 
      Propolis, a natural resinous mixture rich in polyphenols, produced by bees from a variety of
      plant sources, has shown significant therapeutic effects and may prevent the development of
      certain chronic diseases. Current evidence supports the beneficial effect of these bioactive
      phytochemicals on the management of type 2 diabetes mellitus (T2DM) and other chronic
      diseases. The objective of this study is to evaluate the effect of poplar propolis extract
      powder (PPEP) on glucose homeostasis and other clinical parameters in insulin-resistant
      patients (diagnosed by HOMA-IR index > 1.85 for men and > 2.07 for women).
    

Detailed description: 
      Backgroud: Propolis, a natural resinous mixture rich in polyphenols, produced by bees from a
      variety of plant sources, has shown significant therapeutic effects and may prevent the
      development of certain chronic diseases. Current evidence supports the beneficial effect of
      these bioactive phytochemicals on the management of type 2 diabetes mellitus (T2DM) and other
      chronic diseases. The objective of this study is to evaluate the effect of poplar propolis
      extract powder (PPEP) on glucose homeostasis and other clinical parameters in
      insulin-resistant patients (diagnosed by HOMA-IR index > 1.85 for men and > 2.07 for women).

      Methods: The trial was a randomized, controlled, crossover, intervention study.
      Insulin-resistant patients (n=9) (8 women, 1 man), with a mean ± SD age 49 ± 7, were
      subjected to two periods of supplementation (propolis and placebo) for 3-months, separated by
      a 2-week washout period. The quantity of propolis administered was determined individually to
      reach 6 mg of polyphenols/kg. Fasting blood test and oral glucose tolerance test (OGTT) were
      performed before and after each treatment.
    

Intervention name(s): Propolis; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Propolis supplements were packaged in marine capsules and consisted of poplar propolis powder (propolis concentrate, carob powder, magnesium stearate and silicon dioxide), concentrated to 30% total polyphenols.
Each supplementation period lasted 3 months, with a 2-week wash-out period, to allow total excretion of polyphenols by the body and do not interfere with the new supplementation phase.
The subjects in this study were submitted to five visits, allowing the tracking of biological parameters (clinical examination, fasting blood samples, HGPO) during the study. During the supplementation phases, follow-up by telephone call was performed.; Placebo powder capsules (maltodextrin, fatty acids, magnesium salts and silicon dioxide) are presented in the same packaging to have an identical appearance and taste. Patients in the propolis group were dosed with propolis to reach 6 mg total polyphenols/kg body weight, based on the results of a previous preclinical study in mice.
Each supplementation period lasted 3 months, with a 2-week wash-out period, to allow total excretion of polyphenols by the body and do not interfere with the new supplementation phase.
The subjects in this study were submitted to five visits, allowing the tracking of biological parameters (clinical examination, fasting blood samples, HGPO) during the study. During the supplementation phases, follow-up by telephone call was performed.
Intervention MeSH terms: Propolis
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: The present trial was a randomized, double-bind, controlled, crossover, dietary intervention study. During this trial, two types of supplementations were randomly administered during two treatment periods (propolis and placebo), using a random number table. The placebo served as the reference group for comparison. Participants and caregivers were blinded to the type of treatment consumed.
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Prevention
Keywords: Propolis