Effects of Probiotics Improves the Endurance and Explosiveness Exercise Performance on Healthy Human.
Condition: Exercise Performance
Study type: Interventional

Summary: 
      This study may discover that supplementing with probiotics LY-66, PL-02 can promote exercise
      endurance, explosive power and reduce muscle inflammation index in healthy people.
    

Detailed description: 
      With the rise of people's health awareness and exercise habit in recent years, and the demand
      for the use of sports health food supplements has also increased. Probiotics are generally
      recognized as safe and helpful in digestion in the gastrointestinal tract. Previous animal
      experiments have found that probiotics LY-66, PL-02 are more effective in promoting the grip
      and exhausting exercise in mice. The purpose of this study is to further explore the effects
      of probiotics LY-66, PL-02 on promoting exercise endurance and explosive power in healthy
      people. This study is to compare supplementary samples with placebo and adopt a double-blind
      study design. 88 healthy adult males and females (non-sports players) aged 20-40 will be
      recruited, 44males and 44 females, with an average number of male and female subjects in each
      group, and they will be randomly assigned to the (A) placebo group, (B) LY-66 probiotic
      group, (C) PL-02 probiotics group, (D) LY-66/PL-02 doublet probiotics group. Supplemented one
      time a day, take 15 billion CFU of probiotics each time for 42 consecutive days. During the
      period of taking probiotics, squats and TABATA training were set for the subjects 2 days a
      week. From day 0 to day 42 of supplementation, subjects in each group were tested physical
      fitness and cardiorespiratory endurance every 14 days. On the 21th days, the explosiveness of
      muscle strength in each group was tested with Wingate. On the 42nd day, the exercise
      endurance test, NGS and GC-MS technology was used to detect the fecal microbiota and
      SCFA(Short-chain fatty acids) in each group, body inflammation index of each group were
      tested and use questionnaire to evaluate subjective experience. This study may discover that
      supplementing with probiotics LY-66, PL-02 can promote exercise endurance, explosive power
      and reduce muscle inflammation index in healthy people.
    

Intervention name(s): Placebo; Probiotic 1,Lactococcus lactis subsp. lactis, LY-66; Probiotic 2,Lactobacillus plantarum, PL-02; Probiotic 3,Lactococcus lactis subsp. lactis, LY-66+Lactobacillus plantarum, PL-02
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Subjects take two packs once a day, and make a 250 ml water solution for drinking.; Subjects take two packs once a day, and make a 250 ml water solution for drinking.; Subjects take two packs once a day, and make a 250 ml water solution for drinking.; Subjects take two packs once a day, and make a 250 ml water solution for drinking.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Probiotics; Intestinal flora; Exercise Performance