Lenalidomide in Treating Patients With Relapsed Mycosis Fungoides/Sezary Syndrome
Condition: Lymphoma
MeSH terms: Mycoses; Lymphoma; Mycosis Fungoides; Sezary Syndrome
Study type: Interventional
Phase: Phase 2

Summary: 
      RATIONALE: Lenalidomide may stop the growth of mycosis fungoides/Sezary syndrome by blocking
      blood flow to the cancer.

      PURPOSE: This phase II trial is studying how well lenalidomide works in treating patients
      with relapsed mycosis fungoides/Sezary syndrome.
    

Detailed description: 
      OBJECTIVES:

      Primary

        -  Determine the response rate and duration of response in patients with relapsed mycosis
           fungoides/Sézary syndrome treated with lenalidomide.

        -  Determine the progression-free survival of patients treated with this drug.

      Secondary

        -  Determine the toxicity of this drug in these patients.

        -  Correlate the antiangiogenetic and costimulatory effects of this drug with clinical
           activity in skin biopsies from these patients.

        -  Assess the specific immune effector cell recruitment and augmentation of antitumor
           response in these patients. (Northwestern University only)

      OUTLINE: This is a multicenter study.

      Patients receive oral lenalidomide once daily on days 1-21. Treatment repeats every 28 days
      for 2 courses. Patients with progressive disease are removed from study. Patients achieving
      complete response receive 2 additional courses of treatment beyond complete response.
      Patients achieving partial response or stable disease may continue to receive lenalidomide as
      above for up to 2 years. Treatment continues in the absence of disease progression or
      unacceptable toxicity.

      Patients undergo tissue biopsies at baseline and on day 1 of course 2. Tissue specimens are
      analyzed for vessel density, presence of adhesion molecules, and immunophenotyping of dermal
      infiltrate.*

      NOTE: *At Northwestern University only, blood and tissue samples from 5-10 patients are
      collected. Peripheral blood samples are analyzed for immune cell repertoire (CD4+, CD8+ T
      cells, NK cells, NKT cells, CD4+, CD25+ T-regulatory cells, monocytes, and dendritic cell
      subsets), cell surface molecules, and for TH1/TH2-associated cytokines, such as interleukin
      (IL)-2, IL-4, IL-10, IL-12, interferon gamma, and tumor necrosis factor alpha, by flow
      cytometry at baseline, day 15 of course 1, and at the end of course 1. Immunological
      activation is assessed by analyzing surface expression of CD45RO and CTLA-4 on CD4+ and CD8+
      T cells in blood and skin samples. Skin specimens are stored for future research studies on
      predictive markers of lenalidomide activity.

      After completion of study treatment, patients are followed every 3 months for 1 year.

      PROJECTED ACCRUAL: A total of 35 patients will be accrued for this study.
    

Intervention name(s): lenalidomide
Intervention type(s): Drug
Intervention description(s): 10 mg daily orally administered on days 1 - 21 followed by 7 days rest of a 28-day cycle, increasing dose by 5 mg every cycle, up to a maximum of 25 mg.
Intervention MeSH terms: Lenalidomide
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: recurrent mycosis fungoides/Sezary syndrome; stage I mycosis fungoides/Sezary syndrome; stage II mycosis fungoides/Sezary syndrome; stage III mycosis fungoides/Sezary syndrome; stage IV mycosis fungoides/Sezary syndrome