bioihbjkbjnl/mcl2 huggingface dataset:
Etiology of Eczema Herpeticum (EH)
Condition: Eczema Herpeticum
MeSH terms: Kaposi Varicelliform Eruption; Eczema
Study type: Observational

Summary: 
      Atopic dermatitis, also called eczema, is a disease with dry, scaly, itchy skin. Those with
      atopic dermatitis may have complications from skin infections such as eczema herpeticum after
      herpes simplex virus (HSV) infection. Symptoms of eczema herpeticum include fever and
      clusters of itchy blisters which crust over and form sores. Although exposure to HSV is
      widespread, most people clear the virus and only a subset of individuals with atopic
      dermatitis develop eczema herpeticum.

      The purpose of this study is to determine why some individuals with atopic dermatitis are at
      higher risk for recurrent skin infections with HSV. The study team will compare how people
      with atopic dermatitis with a history of recurrent eczema herpeticum, people with atopic
      dermatitis without a history of eczema herpeticum, and people without atopic dermatitis
      respond to HSV.
    

Detailed description: 
      This study uses whole genome sequencing (WGS) technology to identify genetic variants that
      confer risk of recurrent atopic dermatitis with a history of eczema herpeticum (ADEH+), with
      ≥3 eczema herpeticum (EH) episodes.

      A small subgroup of individuals with atopic dermatitis (AD) suffer from life-threatening
      disseminated herpes simplex virus (HSV) skin infections, termed eczema herpeticum (ADEH+).
      The manifestation of ADEH+ however is not simply a consequence of herpes simplex virus type 1
      (HSV-1) infections, since the majority of the US population is latently infected with HSV-1
      from an early age. Most importantly, there is a bimodality in the recurrence of eczema
      herpeticum (EH) episodes; most individuals have only a single episode but a subgroup of ADEH+
      individuals has 3 or more episodes.

      This study aims to conduct an extreme trait investigation of ADEH+ with recurrent EH, ≥3
      episodes, compared to AD without a history of eczema herpeticum (ADEH-), using whole genome
      sequencing.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        A minimum of 50 recurrent Atopic Dermatitis with a history of Eczema Herpeticum(ADEH+), 500
        Atopic Dermatitis without a history of Eczema Herpeticum (ADEH-), and 237 Non-Atopic (NA)
        European American participants from the Atopic Dermatitis Research Network (ADRN) DNA
        Repository. The protocol will also enroll two independent populations of participants 1)
        children, 3-17 years of age and 2) adults 18-64 years of age. A minimum of 12 recurrent
        ADEH+ with ≥3 EH episodes, 12 ADEH- and 12 NA participants will be enrolled in each of the
        two populations.
      
Biospecimen description: 
      Blood and Skin Tissue
    
Keywords: whole genome sequencing (WGS)
RBC Transfusion in Severe Anemia With Lactic Acidosis
Condition: Anemia
MeSH terms: Anemia
Study type: Interventional
Phase: Phase 3

Summary: 
      The hypothesis of this study is that prolonged-storage RBCs are not inferior to short-storage
      RBCs for the time required to clear elevated blood lactate levels in children with severe
      anemia.
    

Detailed description: 
      This study will measure the time to resolution of lactic acidosis in patients with severe
      anemia following blood transfusion.
    

Intervention name(s): RBC transfusion
Intervention type(s): Biological
Intervention description(s): RBC transfusion of different storage age
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Anemia; Transfusion; RBC storage age; Tissue oxygenation; Malaria
Elongation of Foveal Tissue After Macular Hole Surgery
Condition: Macular Holes
MeSH terms: Retinal Perforations
Study type: Interventional

Summary: 
      In our experience, elongation of foveal tissue after macular hole surgery which was
      undetectable by conventional time-domain optical coherence tomography was often observed on
      spectral-domain optical coherence tomography images. Elongation of tissues inevitably induces
      some degree of disorganization of tissue microstructure.

      The purpose of the present study was to evaluate elongation profile of foveal tissue after
      macular hole surgery and to investigate its impact on visual acuity and metamorphopsia.
    


Intervention name(s): pars plana vitrectomy and fluid gas exchange
Intervention type(s): Procedure
Intervention description(s): A three-port standard pars plana vitrectomy was performed by a single surgeon using a 23-gauge vitrectomy system, either Associate®(Dutch Ophthalmic Research Center. Inc., Zuidland, The Netherlands) or Accurus®(Alcon Laboratories Inc., Fort Worth, USA), with one step scleral tunnel incision. In all cases, the peeling of the internal limiting membrane, approximately 1 disc diameter area from center of MH was conducted without assistance of dyes followed by complete fluid-gas exchange using 25% sulfur hexafluoride gas. Combined cataract surgery was performed in patients with visually significant cataracts or with incipient cataract in the subjects older than 60 years. All patients were instructed to maintain a face-down position for at least 7 days postoperatively.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Macular Holes; spectral domain optical coherence tomography; elongation of foveal tissue; M-score
Anatomical and Biomechanical Study About Stability in Galeazzi´s Fracture
Condition: Galeazzi's Fracture
MeSH terms: Fractures, Bone; Radius Fractures
Study type: Observational [Patient Registry]

Summary: 
      Most Galeazzi fractures can be treated adequately with open reduction and internal fixation
      (ORIF) of the radius alone, but some will remain unstable at the DRUJ and require repair of
      the TFCC.The purpose of this anatomical and biomechanical study was to define and measure
      DRUJ dislocation, displacement and instability associated with the sequential sectioning of
      the different bands in the interosseous membrane (IOM) and TFCC in the simulation of a
      Galeazzi fracture.
    

Detailed description: 
      Instability of the DRUJ is a common clinical problem associated with Galeazzi fracture.
      Stability of the DRUJ is primarily provided by both the bony anatomy of the sigmoid notch of
      the radius and ulnar head and the soft tissues surrounding the joint. The interosseous
      membrane plays an important role in DRUJ stability but the TFCC is the major soft tissue
      stabilizer of the DRUJ. The Central Band works as a restraint on the radius from proximal
      migration in cooperation with the radial head and the TFCC and also works as a load
      transmitter between the radius and ulnar to redistribute load. Some investigators suggested
      that the distal membranous portion and DOB stabilizes the DRUJ when TFCC is disrupted.
      Watanabe et al. (2005) insisted on the importance of DOB, which constrained volar and dorsal
      instability of the radius at the DRUJ in all forearm rotation positions. The purpose of this
      anatomical and biomechanical study was to define and measure DRUJ dislocation in the
      simulation of a Galeazzi fracture.
    

Intervention name(s): Open reduction and internal fixation
Intervention type(s): Procedure
Intervention description(s): Open reduction of the Galeazzi fracture dislocation with a plate.
Other intervention name(s): DRUJ reduction with Kirschner wire
Observational model: Cohort
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        Anatomical and biomechanical study: Twelve specimens from the Human Anatomy Department.

        Clinical study: Review of reports (X-rays) about patients with Galeazzi
        fracture-dislocation treated with ORIF.
Efficacy and Safety of Etelcalcetide (AMG 416) in the Treatment of Secondary Hyperparathyroidism (SHPT) in Patients With Chronic Kidney Disease (CKD) on Hemodialysis
Condition: Hyperparathyroidism, Secondary
MeSH terms: Neoplasm Metastasis; Kidney Diseases; Renal Insufficiency, Chronic; Hyperparathyroidism; Hyperparathyroidism, Secondary
Study type: Interventional
Phase: Phase 3

Summary: 
      This study is designed to assess the efficacy and safety of etelcalcetide (AMG 416) compared
      with placebo in the treatment of SHPT in CKD patients receiving hemodialysis.
    


Intervention name(s): Etelcalcetide; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Administered intravenously three times per week. The starting dose was 5 mg. The dose may have been increased at weeks 5, 9, 13, and 17 (4-week intervals) by 2.5 mg or 5 mg on the basis of the predialysis parathyroid hormone and corrected calcium concentrations obtained in the prior week. The minimum dose was 2.5 mg and the maximum dose was 15 mg.; Administered intravenously (IV) three times per week.
Other intervention name(s): AMG 416
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Secondary Hyperparathyroidism (SHPT), chronic kidney disease (CKD), hemodialysis, parathyroid hormone (PTH), hypocalcemia, bone and mineral metabolism
L Test in Children With Cerebral Palsy
Condition: Cerebral Palsy
MeSH terms: Paralysis; Cerebral Palsy
Study type: Observational [Patient Registry]

Summary: 
      The aim of the study was to investigation of the validity and reliability of the L test in
      children with cerebral palsy. Eighty children with CP with mean age of 11.60±3.85 (56 boys,
      24 girls) were included in the study. ICC ((Intraclass Correlation Coefficient) was used to
      assess interclass, intraclass and test- retest validity of the L test. Two independent
      examiners made L test, for the inter-rater reliability, twice within 1 day for the
      test-retest reliability. The minimal clinical important difference at 95% confidence interval
      intra-class correlation coefficient and standard error of measurements were calculated. The
      correlations of L test with Timed up and Go Test (TUG) and Timed up and Down Stairs Test
      (TUDS) were assessed for concurrent validity.
    

Detailed description: 
      Inclusion criteria were: cerebral palsy diagnosis, absence of other diseases that may impact
      gait performance, ambulatory for at least 20 meters, maximum level 2 according to Gross Motor
      Function Classification System. Exclusion criteria were: difficulty in following the
      instructions, severe lower extremity pain that affects mobility, orthopedic surgery within
      the last 12 months, Bothulium toxin A injection for lower extremity within the last 3 months
      and walking with a physical assistance from another person. Informed consents were obtained
      from the parents of the participants for the trial. Assessments were conducted in a special
      training and rehabilitation center where children with cerebral palsy received regular
      treatments.
    

Observational model: Other
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        children with cerebral palsy
      
Keywords: L test; cerebral palsy; children; validity; reliability
Influence of Organic Anion Transporting Polypeptide1B1(OATP1B1) Genotype on Rosuvastatin PK, PD and Lipid Profiles
Condition: Organic Anion Transporting Polypeptide1B1 (OATP1B1); Rosuvastatin
Study type: Interventional
Phase: Phase 4

Summary: 
      This study aimed to explore the influence of organic anion transporting polypeptide1B1
      (OATP1B1) genotype on pharmacokinetics, lipid lowering effect and lipid profiles after
      rosuvastatin administration.
    

Detailed description: 
      Open, one arm, single sequence study for healthy volunteers are investigated. Thirty four
      subjects may be enrolled.

      Rosuvastatin are administered once a day for 21 days. Before and after rosuvastatin
      administration, PK, PD and lipid profiles are investigated.
    

Intervention name(s): Rosuvastatin
Intervention type(s): Drug
Intervention description(s): 20 mg once daily for 21 days
Intervention MeSH terms: Rosuvastatin Calcium
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: OATP1B1; rosuvastatin
Nedaplatin in Treatment for Nasopharyngeal Carcinoma
Condition: Nasopharyngeal Carcinoma
MeSH terms: Carcinoma; Nasopharyngeal Carcinoma
Study type: Interventional
Phase: Phase 2

Summary: 
      To evaluate the efficacy of induction chemotherapy with nedaplatin, docetaxel and
      5-Fluorouracil followed by concurrent nedaplatin combined with radical radiotherapy in
      locally advanced nasopharyngeal carcinoma.
    

Detailed description: 
      This is a prospective, phase II clinical trial to evaluate the efficacy and safety of
      induction chemotherapy with nedaplatin, docetaxel and 5-Fluorouracil followed by concurrent
      nedaplatin combined with radical radiotherapy in locally advanced nasopharyngeal carcinoma
      patients. This is a multicenter study. All patients will be enrolled in endemic area. All
      patients will receive radical intense modulate radiation therapy (IMRT). The primary endpoint
      is objective response rate (ORR).
    

Intervention name(s): Docetaxel, nedaplatin, fluorouracil; IMRT; Nedaplatin
Intervention type(s): Drug; Radiation; Drug
Intervention description(s): Induction chemotherapy. Docetaxel 60 mg/m2 intravenous day1. Nedaplatin 60 mg/m2 intravenous day1. Fluorouracil 3000 mg/m2 continuous intravenous infusion 120 hours from day1. Every 21 days, 3 cycles.; Intensity modulated-radiotherapy (IMRT) is given as 2.0-2.33 Gy per fraction with five daily fractions per week for 6-7 weeks to a total dose of 66 Gy or greater to the primary tumor.; Concurrent chemotherapy. nedaplatin 100 mg/m2 intravenous at day1, 22, 43 of radiotherapy.
Other intervention name(s): DNF; RT; N
Intervention MeSH terms: Docetaxel; Fluorouracil; Nedaplatin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Induction chemotherapy; Nedaplatin; Concurrent chemoradiotherapy; Nasopharyngeal Carcinoma
Benefit of IQP-AS-118 on Blood Pressure and LDL-cholesterol
Condition: Blood Pressure; Low Density Lipoprotein Cholesterol Level
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the benefit and tolerability of IQP-AS-118 on the
      systolic and diastolic blood pressure (BP) and to explore the effects on parameters of lipid
      metabolism in subjects with elevated BP and low density lipoprotein cholesterol (LDL-C)
      levels in a pilot study.
    


Intervention name(s): IQP-AS-118; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Take one a day; Take one a day
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Telerehabilitation After Coronavirus
Condition: COVID
Study type: Interventional

Summary: 
      The aim of the study is to investigate the effects of telerehabilitation program on COVID-19
      symptoms, quality of life, level of depression, perception of dyspnea, sleep, fatigue,
      kinesiophobia and patient satisfaction in individuals diagnosed with COVID-19.
    

Detailed description: 
      Because of the risk of infection, telerehabilitation applications are recommended for
      patients with COVID-19. There are no studies in the literature evaluating the effectiveness
      of telerehabilitation program after COVID-19. In particular, the importance of the first
      eight weeks after the disease was emphasized.

      It is thought that the telerehabilitation program will improve the functional capacities and
      quality of life of patients in order to adapt to the daily life after the infection more
      easily, to cope with the symptoms brought about by the disease more easily and to prevent the
      respiratory distress, intensive care stay and inactivity due to muscle weakness.
    

Intervention name(s): Aerobic Exercise Training; Patient Education; Respiratory Exercise Training
Intervention type(s): Other; Behavioral; Other
Intervention description(s): Aerobic exercises using all body muscles and that one can do on their own after being shown online; Patient education about covid-19 and hygiene education; Respiratory exercises that one can do on their own after being shown online
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: It is planned to include 3 groups in the study. The group 1 will be informed about covid-19 and hygiene. Aerobic exercise will be offered to Group 2, aerobic exercise + breathing exercises will be offered to Group 3. The persons to be included in the groups will be determined randomly.
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: Covid-19; Telerehabilitation; Respiratory Exercises; Aerobic Exercises
Gingival Crevicular Fluid Levels of Protein Carbonyl Following the Use of Lycopene in Chronic Periodontitis
Condition: Chronic Periodontitis
MeSH terms: Periodontitis; Chronic Periodontitis
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Effect of Locally Delivered Antioxidants as An Adjunct to Non-surgical Periodontal Therapy on
      GCF Level of Oxidative Stress Marker; Protein Carbonyl
    

Detailed description: 
      The study was designed as a randomized controlled clinical trial. Total subjects selected
      were allocated into three study groups, Group I (Test group), Group II (Positive control
      group) and Group III (Negative control group). Group I: Included 8 patients with severe
      chronic periodontitis managed by Scaling and root planing and local delivery of lycopene
      loaded in solid lipid microparticles. Group II: Included 8 patients with severe chronic
      periodontitis managed by Scaling and root planing only. Group III: Included 8 patients with
      clinically healthy periodontium.

      Protein carbonyl biomarker level and clinical parameters were assisted to evaluate the effect
      of lycopene as an adjunct to scaling and root planing.
    

Intervention name(s): Lycopene + SRP; SRP only
Intervention type(s): Drug; Procedure
Intervention MeSH terms: Lycopene
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Total subjects selected were allocated into three study groups, Group I (Test group), Group II (Positive control group) and Group III (Negative control group). Group I: Included 8 patients with severe chronic periodontitis managed by Scaling and root planing (SRP) and local delivery of lycopene loaded in solid lipid microparticles. Group II: Included 8 patients with severe chronic periodontitis managed by Scaling and root planing (SRP) only. Group III: Included 8 patients with clinically healthy periodontium.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Lycopene; Chronic periodontitis; Protein carbonyl
Writing About Experiences and Health in Older Adults
Condition: Social Psychology
Study type: Interventional

Summary: 
      UCLA researchers looking for healthy females (age 60+) to participate in a study
      investigating how writing about your experiences may be related to your health.

      Once a week for 6 weeks, participants will write about their experiences and fill out online
      questionnaires. Participants will also come to the UCLA campus for blood draws and to fill
      out questionnaires 3 times: once prior to the 6-week writing period, once immediately after
      the 6-week period, and once 2-months after the writing period.
    


Intervention name(s): Writing: Group 1; Writing: Group 2
Intervention type(s): Behavioral; Other
Intervention description(s): Writing about experiences with familiar individuals in their lives, once a week for 6 weeks.; Writing about experiences with familiar places, once a week for 6 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: Immune System; Behavioral Sciences; Women's Health; Health Psychology; Writing
Motivational Interview Based Discharge Planning for Patients With Diabetic Foot Ulcers
Condition: Diabetic Foot Ulcer
MeSH terms: Diabetic Foot; Foot Ulcer; Ulcer
Study type: Interventional

Summary: 
      To evaluate the effectiveness of a discharge planning using the strategy of motivational
      interviewing among patients with diabetic foot ulcers
    

Detailed description: 
      The purpose of this study is to evaluate the effectiveness of a discharge planning using the
      strategy of motivational interviewing among patients with diabetic foot ulcers.

      A randomized controlled trial design will be used. From August 2020 to July 2022, 132
      patients hospitalized for diabetic foot ulcers will be recruited. They will be randomly
      assigned to either the experimental or the comparison group in the first year, and then they
      will be followed by one year. The control group will receive routine care; the experimental
      group will receive a discharge planning which use the strategy of motivational interviewing.
      The discharge planning will be provided individually at the following time points: before
      discharge, on post-discharge days 3, 7, 14, 21, 28, and then each month till one year.
      Outcome measures include diabetic foot ulcer self-care behaviors and self-efficacy, foot skin
      conditions, glycemic control (measured by HbA1C), the infection rate of foot, and the
      readmission rate. Data will be collected at baseline and at 1, 3, 6, and 12 months after
      discharge.

      The generalized estimating equation (GEE) will be used to evaluate the effect of the
      intervention on the diabetic foot ulcer self-care behaviors and self-efficacy, foot skin
      conditions, and the effect on glycated hemoglobin value reduction. The log-rank test will be
      used to compare the infection rate of foot, and the readmission rate between two groups.
    

Intervention name(s): a discharge planning using the strategy of motivational interviewing
Intervention type(s): Behavioral
Intervention description(s): The experimental group will receive a discharge planning which use the strategy of motivational interviewing. The discharge planning will be provided individually at the following time points: before discharge, on post-discharge days 3, 7, 14, 21, 28, and then each month till one year.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Subjects will be randomly assigned to either the experimental or the comparison group.
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Foot ulcer, motivational interviewing, discharge planning
GSK706769/KALETRA Drug-drug Interaction Study
Condition: Infection, Human Immunodeficiency Virus
MeSH terms: Acquired Immunodeficiency Syndrome; HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      To compare plasma GSK706769 PK following repeat administration of GSK706769 QD with and
      without KALETRA (LPV 400 mg/RTV 100mg) q12h
    


Intervention name(s): GSK706769 & KALETRA
Intervention type(s): Drug
Intervention description(s): GSK706769 alone and GSK706769 + Kaletra
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: KALETRA; GSK706769; HIV; healthy volunteers