bioihbjkbjnl/mcl2 huggingface dataset:
Transversus Abdominis Plan Block, Ultrasound or Laparoscopic?
Condition: Bupivacaine; Anesthetics, Local; Anesthetics; Peripheral Nervous System Agents
Study type: Interventional

Summary: 
      Abdominal wall blocks are frequently used as part of multimodal analgesia for pain control
      after abdominal surgery. There are studies using the Transversus Abdominis Plane Block for
      postoperative pain control in laparoscopic cholecystectomies.

      In this study, the investigators aimed to compare the advantages of these two methods by
      applying the Transversus Abdominis Plan Block for postoperative pain control after
      laparoscopic cholecystectomy with the help of postoperative USG and laparoscopy during
      surgery.In this study, the investigators aimed to compare the advantages of these two methods
      by applying the Transversus Abdominis Plan Block for postoperative pain control after
      laparoscopic cholecystectomy with the help of postoperative USG and LAPAROSCOPY during
      surgery.
    

Detailed description: 
      A total of 60 patients aged 18-65, ASA 1-2-3, who will undergo elective laparoscopic
      cholecystectomy in our hospital, will be included in the study. Patients will be randomly
      divided into 3 groups with ultrasound (USG) guided (GROUP 1: USG) , Laparoscopic application
      (GROUP 2: LAP) and GROUP 3 :No-TAP blok Each group consists of 20 evil people. Written
      consent will be obtained by explaining the procedure to be performed before the operation to
      the patients. The Transversus Abdominis Plan Block will be applied to the patients by a blind
      anesthesiologist according to their group. The block to be made by the anesthesiologist who
      will apply the block procedure will be given in a closed envelope.
    

Intervention name(s): bupivacaine
Intervention type(s): Drug
Intervention description(s): In one arm the TAP infiltration will contain 10 mL of 0.25 % bupivacaine injected . This will then be repeated on the contralateral side.
Intervention MeSH terms: Bupivacaine
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: TAP block; laparoscopy; laparoscopic cholecystectomy
Study of Acetyllevocarnitine Hydrochloride Tablets in Chinese Patients With Paresthesias Caused by DPN
Condition: Diabetic Peripheral Neuropathy (DPN); Paresthesia
MeSH terms: Peripheral Nervous System Diseases; Diabetic Neuropathies; Paresthesia
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to assess the efficacy of Acetyllevocarnitine Hydrochloride
      Tablets compared with placebo after 24 weeks, in chinese patients with paresthesia caused by
      Diabetic Peripheral Neuropathy (DPN).
    

Detailed description: 
      This 24-week, multicentre, randomised, double-blind, placebo-controlled phase III study is to
      assess the efficacy and safety of Acetyllevocarnitine Hydrochloride Tablets in Chinese
      patients with paresthesia caused by DPN.The trial included a 2-week screening period, a
      1-week placebo run-in period, a 24-week randomized treatment period, and a 2-week follow-up
      period.
    

Intervention name(s): Acetyllevocarnitine Hydrochloride Tablets; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 500 mg (2×250 mg/tablet) after meal, 3 times per day; 500 mg (2×250 mg/tablet) after meal, 3 times per day
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Predictive Parameters for Difficult Tracheal Intubation Identification in Thyroid Surgery
Condition: Intubation;Difficult
MeSH terms: Thyroid Diseases
Study type: Observational

Summary: 
      Intubation manoeuvres in patients undergoing thyroid surgery might be challenging for
      anesthesiologist. Thyroid gland enlargement (goiter) or tissue fibrosis (neoplasms) could
      alter the physiologic anatomy of upper airways and trachea, resulting in compression or
      dislocation. We want to evaluate the incidence and identify predictive parameters of
      difficult intubation in patients undergoing thyroid surgery.
    

Detailed description: 
      Intubation manoeuvres in patients undergoing thyroid surgery might be challenging for
      anesthesiologist. Thyroid gland enlargement (goiter) or tissue fibrosis (neoplasms) could
      alter the physiologic anatomy of upper airways and trachea, resulting in compression or
      dislocation.

      There are few scientific data about airway management and thyroid pathology and the incidence
      of difficult tracheal intubation in this specific kind of patient is largely variable from 0%
      to 12.9%. These data have been collected from little statistical samples (from 50 to 326
      patients), the results aren't always unanimous and a study evaluating simultaneously all the
      risk factors for difficult intubation does not exist.

      We want to evaluate the incidence and identify predictive parameters of difficult intubation
      in patients undergoing thyroid surgery.

      During pre-anesthetic assessment the following data will be collected:

      Inter-incisor gap (cm) Mallampati test (1;2;3;4) Thyromental distance (cm) Prognathism (yes;
      no) Neck motility (<80°;80-90°;>90°) Total body weight (kg) History of difficult tracheal
      intubation (yes; no) Tracheal deviation at chest X-Ray (yes; no) Neck circumference (cm)
      Mediastinal goiter (yes; no) Histologic features (benign; carcinoma)

      During the post-anesthesia it will be noted down the following:

      Cormack scale (1; 2a; 2b; 3; 4) Number of necessary attempts to intubate (1;2;3;…) Time from
      induction to intubation (min) Necessity to use advanced airway management devices (Frova;
      Glidescope; Ambu-scope; fiber-optic; other)
    

Intervention name(s): Thyroid surgery
Intervention type(s): Other
Intervention description(s): Patient undergoing thyroid surgery
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        patients undergoing thyroid surgery
      
Keywords: Intubation; Difficult; thyroid
Study Evaluating Ibuprofen 600 mg Extended Release (ER) For Dental Pain
Condition: Pain
MeSH terms: Toothache
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to assess the efficacy and safety of a single dose of an
      ibuprofen 600 mg extended release formulation in post-operative dental pain. There is concern
      that the manufacturing process may affect the performance characteristics of the selected
      prototype. Therefore, two formulations of this prototype manufactured by two different
      processes, [roller compaction] and [wet granulation] will be included in this study. The
      preferred prototype manufactured by two different methods will be compared to placebo and
      each other. This study will also characterize the pharmacokinetic/pharmacodynamic
      relationship with these formulations.
    


Intervention name(s): ibuprofen; ibuprofen; naproxen; Placebo
Intervention type(s): Drug; Drug; Drug; Drug
Intervention MeSH terms: Ibuprofen; Naproxen
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Extended-release; ibuprofen
Experience With a Pediatric Summer Intensive Therapy Program
Condition: Neurodevelopmental Disorders
MeSH terms: Neurodevelopmental Disorders
Study type: Observational

Summary: 
      The purpose of this study is to explore the lived experiences of children with
      neurodevelopmental diagnoses and their caregivers with an intensive model of therapy.
      Children will receive usual care during the summer intensive program and the investigators
      will access medical records to assess effectiveness. Children and caregivers will also be
      asked to participate in semi-structured interviews upon the completion of the episode of
      care.
    

Detailed description: 
      The purpose of this study is to explore the lived experiences of children with
      neurodevelopmental diagnoses and their caregivers with an intensive model of therapy.
      Research questions include: 1.) What are the perceptions of children and caregivers about
      intensive therapy after participating in multiple intensive therapy episodes over time? 2.)
      Why do caregivers choose to continue with an intensive model of therapy periodically for
      their child with neurodevelopmental diagnoses? 3.) What were the outcomes for children with
      neurodevelopmental disabilities participating in an episode of intensive therapy? Children
      will receive usual care during the summer intensive program and the investigators will access
      medical records to assess effectiveness. Children and caregivers will also be asked to
      participate in semi-structured interviews upon the completion of the episode of care.
    

Intervention name(s): Intensive therapy program
Intervention type(s): Other
Intervention description(s): The intensive therapy program consists of physical therapy, occupational therapy, and speech therapy 3-6 hours x 4-5 days/week for 4 weeks. The individual therapies received will vary with the child/caregiver goals and be based on neuroplasticity and motor learning principles.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Children 4-15 years old with neurodevelopmental diagnoses and scheduled for an intensive
        therapy program over the summer.
      
Keywords: pediatric rehabilitation; intensive therapy
HMPL-453 Food Effect and PPI Study in Healthy Volunteer Study
Condition: Intrahepatic Cholangiocarcinoma
MeSH terms: Cholangiocarcinoma
Study type: Interventional
Phase: Phase 1

Summary: 
      A Phase 1, Open-label, 4-Period, Randomized 6-Sequence Study to Evaluate the Effect of Food
      and Rabeprazole, a Proton Pump Inhibitor, on the Pharmacokinetics of HMPL-453 in Healthy
      Volunteers
    


Intervention name(s): HMPL-453; Rabeprazole
Intervention type(s): Drug; Drug
Intervention description(s): 300 mg HMPL-453; 20 mg of rabeprazole will be administered by mouth once daily.
Intervention MeSH terms: Rabeprazole
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Open-label, 4-Period, Randomized 6-Sequence Study
Masking: None (Open Label)
Primary purpose: Treatment
Tolcapone Treatment of Pathological Gambling
Condition: Pathological Gambling
MeSH terms: Gambling
Study type: Interventional
Phase: Phase 2

Summary: 
      The goal of the proposed study is to evaluate the efficacy and safety of tolcapone in
      pathological gambling.
    

Detailed description: 
      The proposed study will consist of 8 weeks of treatment with tolcapone in 10 subjects with
      pathological gambling. The hypothesis to be tested is that tolcapone will be effective in
      reducing the urges to gamble in patients with pathological gambling. The proposed study will
      provide needed data on the treatment of a disabling disorder that currently lacks a clearly
      effective treatment.
    

Intervention name(s): Tolcapone
Intervention type(s): Drug
Intervention description(s): pill, 100-300mg/day for 8 weeks
Other intervention name(s): Brand name: TASMAR
Intervention MeSH terms: Tolcapone
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Gambling; Addiction
Role of Regulatory T Cells in Pathogenesis of Primary IgA Nephropathy
Condition: Glomerulonephritis, IGA
MeSH terms: Glomerulonephritis, IGA; Glomerulonephritis
Study type: Interventional

Summary: 
      Along structural IgA abnormalities, hyperproduction of IgA is thought to play a role in the
      pathogenesis of primary IgA nephropathy. CD4+CD25+Fox3P regulatory T cells are instrumental
      in suppressing adaptative immune responses, including B cells production of immunoglobulins.
      We, the researchers at Centre Hospitalier Universitaire de Saine Etienne, will test the
      hypothesis that IgA production in patients with IgA nephropathy is dysregulated because of a
      quantitative and/or qualitative defect of CD4+CD25+FoxP3+ regulatory T cells.
    


Intervention name(s): gene transcription and cytometry
Intervention type(s): Procedure
Intervention description(s): samply of 30 ml of blood
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: IgA; kidney; Berger'disease; regulatory T cells; pathogenesis of Berger's disease
Effect of Probiotic Inersan and Doxycycline in Chronic Periodontitis
Condition: Chronic Periodontitis
MeSH terms: Periodontitis; Chronic Periodontitis
Study type: Interventional
Phase: Phase 3

Summary: 
      Periodontitis is a multifactorial disease that can lead to the destruction of supporting
      tissues of the teeth resulting in pocket formation, recession or both. Since the primary
      etiological factors for periodontal disease are bacteria in supra and sub gingival biofilm,
      efforts for disease prevention and treatment are mainly focused on pathogen reduction and
      strengthening of epithelial barrier, thus contributing to decreased susceptibility to
      infection. Due to emergence of antibiotic resistance and frequent recolonization of treated
      sites with pathogenic bacteria, there was need for a new treatment paradigm to be introduced
      to periodontal disease. The need was fulfilled by the introduction of Probiotics and
      Bacterial Replacement Therapy. The term probiotic is derived from the Greek, meaning "for
      life" are microorganisms proven to exert health promoting influences in humans and animals.
      Food and Agriculture Organization and WHO have stated that there is potential for probiotic
      foods to provide health benefits and that specific strains are safe for human use.
    


Intervention name(s): Inersan; Doxycycline
Intervention type(s): Drug; Drug
Intervention description(s): Probiotic; Antibiotic
Other intervention name(s): Each lozenge contains not less than 1 billion CFU of Lactobacillus brevis CD2; Each tablet contains 100 mg of Doxycycline
Intervention MeSH terms: Doxycycline
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Exploring Buckwheat's Glucose Lowering Potential
Condition: Type 2 Diabetes
MeSH terms: Diabetes Mellitus, Type 2
Study type: Observational

Summary: 
      Bioactive components in buckwheat enhance insulin sensitivity in Type 2 diabetes by improving
      glucose uptake and utilization through a unique mechanism that operates independent of
      insulin.
    

Detailed description: 
      This is a single site, double-blind, randomized, controlled study designed to explore
      buckwheat's glucose lowering effects in healthy volunteers and volunteers with type 2
      diabetes. A total of 24 volunteers consisting of 12 volunteers (healthy and diabetic) per
      group for both the acute and chronic phases of testing will be recruited through
      advertisement from the local community.

      In the acute testing phase, volunteers (healthy and diabetic) will be asked to attend 4
      visits one week apart for the duration of 3 hours per visit. A fasting blood sample will be
      collected at each visit. At each visit, all volunteers will consume in random order 1 of the
      following 4 products: i) crackers containing buckwheat; ii) crackers without buckwheat); iii)
      50 mls of oral solution containing glucose; or iv) 50 mls of oral solution containing the
      sugar substitute Splenda. The crackers will contain equal amounts of available carbohydrates.
      Blood sampling will occur at 15, 30, 45, 60 minutes, and then every 60 minutes for the
      remainder of the visit. Sampling (pre and post product consumption) will measure insulin,
      glucose, and various incretins. Open venous access will be secured after the first sample has
      been obtained to minimize the number of needle pricks. Total amount of blood obtained will
      not exceed 30 mls per visit.

      In the chronic testing phase, volunteers (healthy and diabetic) will receive the crackers
      containing buckwheat for consumption each day for 7 days. Prior to food consumption, a
      fasting blood sample will be obtained each day and a urine sample will be collected on Days
      1, 3, and 7 to assess bioavailability of buckwheat compounds (concentrations in blood and
      urine), insulin and glucose. Sampling for a lipid profile (total cholesterol,
      LDL-cholesterol, HDL-cholesterol and triglycerides), liver (ALT), kidney (creatinine),
      adipose function (adipokines), various incretins, as well as inflammatory status (various
      cytokines) will be done on Day 1 and Day 7. Total amount of blood obtained will not exceed 30
      mls per visit.
    

Intervention name(s): buckwheat, rice crackers, glucose, sugar substitute
Intervention type(s): Other
Intervention description(s): crackers contain equal amounts of available carbohydrates; 50 mls of oral solution for both glucose and Splenda
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        A total of 24 volunteers were recruited from the community; 12 healthy volunteers and 12
        volunteers with Type 2 Diabetes
      
Keywords: functional food study
A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Various Degrees of Hepatic Impairment
Condition: Hepatic Impairment
MeSH terms: Liver Diseases
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of the study is to evaluate the pharmacokinetics (PK) of a single dose
      of olpasiran in participants with mild, moderate, or severe hepatic impairment compared to
      participants with normal hepatic function.
    


Intervention name(s): Olpasiran
Intervention type(s): Drug
Intervention description(s): Subcutaneous injection
Other intervention name(s): AMG 890
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Olpasiran; Hepatic Impairment; Normal Hepatic Function; AMG 890
Effect of Hemodialysis Membranes on Platelet Count
Condition: Thrombocytopenia
MeSH terms: Thrombocytopenia
Study type: Observational

Summary: 
      The purpose of this study is to determine if there is a drop in platelet count after
      hemodialysis. Hemodialysis membranes are known to activate complement and cause a drop in
      platelets and sometimes in white blood cells. The investigators are going to study one of the
      membranes which is the Fresenius Optiflux® to check if it causes a drop in platelets.
    


Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Patients were being selected from the community where undergoing dialysis.
Impact of the NO-donor Pentaerythrithyltetrantrate on Perinatal Outcome in High-risk Pregnancies
Condition: High Risk Pregnancy
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Pregnancies resulting in IUGR and also in preeclampsia are strongly associated with typical
      underlying placental pathology revealing small placentas and maldevelopment of the decidual
      blood vessels, suggesting under-perfusion from the maternal circulation. Since nitric oxide
      (NO) donors can improve decreased uteroplacental perfusion without any negative effects on
      fetal circulation, these may prevent negative pregnancy outcomes in patients at risk.

      The aim of this study is to evaluate the effectiveness of the long-lasting NO donor
      pentarythrithyltetranitrate (PETN) to reduce the likelihood of adverse pregnancy outcomes
      (intrauterine growth retardation / IUGR, perinatal death, placental abruption, and preterm
      delivery) in women recognized to be at risk for this outcome by abnormal uterine flow in mid
      gestation.
    


Intervention name(s): PETN; Placebo control
Intervention type(s): Drug; Drug
Intervention description(s): Pentaerythrithyltetranitrate: 80 mg orally twice a day; orally, twice daily
Other intervention name(s): Pentalong®, , Actavis Germany, Langenfeld, Germany
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: abortion; perinatal death; IUGR; preterm birth; placental abruption; preeclampsia
Hypertonic Saline Enhances The Field of View of Clinicians and Ease of Procedures
Condition: Nasopharyngeal Diseases
MeSH terms: Nasopharyngeal Diseases
Study type: Interventional
Phase: Phase 4

Summary: 
      Transnasal Flexible Pharyngolaryngoscopy (NPL) is one of the most common and fundamental
      evaluation procedures in otolaryngologist's practice, performed in both outpatient and ward
      settings.In the studies the desired properties for an effective topical agent to be used in
      patients undergoing NPL. To date, only a local anesthetic and/or decongestant substance is
      applied to the nostrils to relieve pain. However, to date, no studies have been performed in
      which intranasal hypertonic saline was used prior to nasal endoscopy.
    

Detailed description: 
      NPL is a technique that has been used for more than 100 years and increases brightness,
      magnification and the ability to take still and video images (3). NPL is a simple, safe,
      cost-effective, and generally well-tolerated procedure. However, a portion of patients may
      refuse to allow the procedure to be repeated as they find it uncomfortable, intolerable, or
      painful.To date, only a local anesthetic and/or decongestant substance is applied to the
      nostrils to relieve pain and increase the field of view and to reduce the duration of
      examination and unpleasant sensations for the patient on NPL procedures.This randomised
      control trial was undertaken to compare the application of nasal hypertonic sea water (3.5%)
      with nasal lidocaine 10%, topical nasal decongestant xylometazoline 0.1% (OtrivineTM) and
      nasal isotonic serum physiologic as placebo group in relation to how they effectively improve
      the adequacy of the examination and if they reduce pain and discomfort associated with
      endoscopic nasal examination.
    

Intervention name(s): Intranasal solutions application were done including one solution for per patient before nasoendoscopy procedure according to randomization
Intervention type(s): Other
Intervention description(s): Hypertonic sea water, Vemcaine, Otrivine, and a placebo were applied by intranasal before the nasoendoscopy procedure for improving the field of view of clinician and reducing the patient discomfort.
Other intervention name(s): intranasal hypertonic sea water (Ancient Secrets, USA); intranasal lidocaine (Vemcaine AstraZeneca, Södertälje, Sweden); intranasal xylometazoline (Otrivine, GlaxoSmithKline, Brentford, UK); intranasal isotonic saline (Deva, Istanbul, TR)
Intervention MeSH terms: Lidocaine; Xylometazoline
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A Double Blind, Randomized, Controlled Trial
Masking: Double (Participant, Investigator)
Primary purpose: Other
Keywords: hypertonic saline solutions; lidocaine; oxymetazoline; isotonic saline; discomfort