A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome
Condition: Metabolic Syndrome; Coronary Artery Disease
MeSH terms: Coronary Artery Disease; Myocardial Ischemia; Coronary Disease; Metabolic Syndrome; Syndrome
Study type: Interventional

Summary: 
      The aim of this study is to explore the role of Canonical β-catenin/Wnt and forkhead box O
      (FOXO) pathways by means of investigating their target genes in coronary artery disease (CAD)
      pathogenesis and to examine the effects of resveratrol (RES) on these pathways in CAD
      patients.
    

Detailed description: 
      Metabolic syndrome is a constellation of cardiovascular and metabolic risk factors including
      obesity, insulin resistance, hypertension and dyslipidemia. Coronary artery disease (CAD) is
      considerably linked with these risk factors. Oxidative stress has a major role in development
      of atherosclerosis that is believed as the most common pathologic process underlying CAD. The
      up-regulated gene-expression of free radical scavenging enzymes such as manganese superoxide
      dismutase (MnSOD) by members of the forkhead box O (FOXO) transcription factors is considered
      to be one of the paramount cell defensive mechanisms against oxidative damage. It is now well
      recognized that β-catenin binds to FOXOs during oxidative stress and acts as the pivotal
      mediator in canonical Wnt signaling, so that it translocates to the nucleus and interacts
      with the family of transcription factors T-cell factor/lymphoid enhancer factor (TCF/LEF), to
      regulate the expression of Wnt target genes. Recent evidence suggested that the canonical Wnt
      signaling plays a profound role in regulation of lipid metabolism and glucose homeostasis.
      Peroxisome proliferator-activated receptor delta (PPAR-δ) is one of the Wnt target genes
      which is believed to be operative in cardiometabolic protection. Interestingly, it has been
      demonstrated that impaired Wnt signaling pathway is contributed to inflammation, foam cell
      formation, and endothelial dysfunction which are recognized as atherosclerosis pathogenic
      factors. Resveratrol (RES) (3, 4´, 5 trihydroxystilbene), a natural polyphenol with
      antioxidant effects can be found in red grapes and its processed drinks (e.g. red wine),
      peanuts, pomegranates and mulberries.Increasing body of evidence suggest a protective role
      for RES against CAD, however the underlying mechanisms still remain to be elucidated. We
      perform this study on 10 metabolic syndrome patients with three-vessel CAD and 10 sex-aged
      matched (men with 40-55 years old) healthy subjects as controls. The effects of RES on
      β-Catenin, manganese superoxide dismutase (MnSOD), and peroxisome proliferator-activated
      receptor delta (PPAR-δ) expression are evaluated in peripheral blood mononuclear cells
      (PBMCs) of participants.
    

Intervention name(s): Resveratrol (3, 4´, 5 trihydroxystilbene)
Intervention type(s): Dietary Supplement
Intervention description(s): Resveratrol (RES) (3, 4´, 5 trihydroxystilbene)
Intervention MeSH terms: Resveratrol
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Coronary artery disease; Metabolic syndrome; Resveratrol; β-catenin; Wnt signaling; FOXO; MnSOD