Sideritis Supplementation, Oxidative Stress and Health
Condition: Oxidative Stress; Lipidemia
MeSH terms: Hyperlipidemias
Study type: Interventional

Summary: 
      The aim of the present clinical study is to estimate the efficacy of a Sideritis Scardica
      extract (SidTea+), derived from the Greek mountain Taygetos, in regulating antioxidant and
      health biomarkers in healthy adults.
    

Detailed description: 
      Introduction: The mountain tea of genus Sideritis has more than 150 species, which are mainly
      distributed in the Mediterranean area. In the literature, extensive reference is made to the
      secondary metabolites of Sideritis, the main ones of which are terpenoids (i.e., iridoids and
      kauranes) and phenolic derivatives (i.e., flavonoids, phenolic acids, phenylethanoid
      glycosides). Polyphenols exhibit a wide range of biological activities, such as
      anti-atherogenic, anti-cancer, anti-mutagenic, anti-inflammatory and antimicrobial
      properties. Among phenolic derivatives, major significance is given to flavonoids, due to
      their antioxidant, anti-inflammatory, antibacterial, antiviral and anti-allergic properties
      in various pathologies. Flavonoids mainly act as antioxidants, inhibiting free
      radical-induced cytotoxicity and lipid peroxidation. Moreover, these compounds are known to
      inhibit tumor growth and proliferation and act as weak agonists or antagonists of estrogens
      by regulating endogenous hormonal activity. In these ways, they can protect against chronic
      diseases such as atherosclerosis and cancer and regulate menopausal symptoms.

      Purpose: This study aims to investigate the effect of a Sideritis Scardica extract (SidTea+)
      supplement from the Greek mountain Taygetos on health and oxidative stress indicators in
      healthy individuals. The results of the present investigation will help to elucidate the
      effects of an extract derived from a plant product on markers of health and oxidative stress
      in apparently healthy individuals.

      Methodology: 30 healthy individuals will be enrolled in the study. Participants will give
      their informed consent after they will be informed about the purposes, procedures, risks and
      benefits associated with the study. Participants will be randomly allocated to either a
      Sideritis spp or a placebo supplementation group and they will consume 1500 mg/day of
      Sideritis or placebo, distributed in three equal doses (every 8 hours) for one month. At
      baseline and post-intervention, volunteers will be assessed for their anthropometric profile,
      muscle function and cardiorespiratory capacity and will provide a resting blood sample for
      the assessment of oxidative stress and health biomarkers. Participants will be asked to
      record their diet for 3 days prior to the study and they will be asked to follow the same
      dietary pattern for 3 days before the post-intervention assessments.
    

Intervention name(s): Sideritis Scardica (SidTea+) extract supplementation; Placebo supplementation
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 1500 mg of Sideritis Scardica (SidTea+) extract per day, divided into 3 equal doses of 500 mg (every 8 hours) for a total duration of 1 month; 1500 mg of placebo per day, divided into 3 equal doses of 500 mg (every 8 hours) for a total duration of 1 month
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Sideritis; Extract; Antioxidants; Oxidative stress; Health