bioihbjkbjnl/mcl2 huggingface dataset:
Contrast-Enhanced Intraoperative Ultrasound During Liver Surgery for Colorectal Cancer Liver Metastases
Condition: Colon Cancer Liver Metastasis
MeSH terms: Neoplasm Metastasis; Liver Neoplasms
Study type: Observational

Summary: 
      Contrast-enhanced intraoperative ultrasound (CE-IOUS) during surgery for colorectal liver
      metastases (CLM) has become a part of clinical practice. However, if it should be selectively
      or routinely applied remains unclear. This study is carried out to clarify which are the
      criteria for a selective use of CE-IOUS if any.
    

Detailed description: 
      Contrast-enhanced intraoperative ultrasound (CE-IOUS) during surgery for colorectal liver
      metastases (CLM) is entered in clinical practice. However, its impact seems to decrease with
      the improvement of preoperative imaging. Therefore, if CE-IOUS should be selectively or
      routinely applied remains unclear: a profile of patients who may benefit of CE-IOUS
      application has to be disclosed. The aim of this study is to define reliable criteria for a
      selective use of CE-IOUS during surgery for CLM. IOUS is performed using 3-6 MHz convex
      probe, and a 7.5-10 MHz micro convex probe. Staging is completed by CE-IOUS using the
      standard 3-6 MHz convex probe and the dedicated 1.88-3.76 MHz harmonic frequency probe. In
      all patients, 2.4 mL of sulphur-hexafluoride microbubbles (SonoVue®, Bracco, Milan, Italy)
      are injected through a peripheral vein by the anesthesiologist. Ultrasound guidance is used
      to drive the dissection plane as previously described. Reference standards are histology and
      imaging at 6 months after surgery. Univariate and multivariate analyses are performed.
      Statistical significance is set at P=0.05.
    

Intervention name(s): Contrast-enhanced intraoperative ultrasound
Intervention type(s): Procedure
Intervention description(s): After entering the abdominal cavity, liver mobilization is achieved by dissecting the round and falciform ligaments. IOUS is carried out with a standard 3-6 MHz convex probe, and a 7.5-10 MHz micro convex probe. Staging was completed by CE-IOUS using the standard 3-6 MHz convex probe and the dedicated 1.88-3.76 MHz harmonic frequency probe. In all patients, 2.4 mL of sulphur-hexafluoride microbubbles (SonoVue®, Bracco, Milan, Italy) are injected through a peripheral vein by the anesthesiologist.
Other intervention name(s): Sonovue, Sonazoid, CEIOUS
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Consecutively enrolled patients with CLM who underwent surgery and during this procedure
        received IOUS and CE-IOUS.
      
Keywords: CLM
Pulmonary Tuberculosis Patients With Diabetes Mellitus
Condition: Diabetes Mellitus; Pulmonary Tuberculosis
MeSH terms: Tuberculosis; Tuberculosis, Pulmonary; Diabetes Mellitus
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the effect of enhanced glycemic monitoring of
      diabetes upon diabetes glycaemic control during tuberculosis treatment in tuberculosis-
      diabetes patients.
    

Detailed description: 
      Tight glycemic control may improve tuberculosis (TB) treatment outcome and help reduce
      symptoms. However, active TB and TB treatment hamper glycemic control. Patients starting TB
      treatment experience rapid changes in appetite, body composition, and inflammation (which
      increases insulin resistance); inflammation is a feature of untreated TB and following an
      increase as a result of initial bacterial killing, inflammation subsides with successful
      treatment. In addition, TB medication (rifampicin) increases the metabolism of oral
      anti-diabetic drugs including the widely used sulphonylureas and thiazolidinediones, though a
      possible interaction with the antidiabetic drug metformin has not been previously examined.
      Frequent monitoring of blood glucose with adjustments in anti-diabetes medication during the
      course of TB treatment may therefore be needed. However, frequent monitoring is associated
      with additional costs, and tools and skills for glucose monitoring and diabetes treatment may
      be lacking in TB or pulmonary clinics, creating a need to refer patients to other health
      providers. As such, a less intense schedule, preferably following the established decision
      points in TB treatment after 2 and 6 months would offer significant advantage. None of these
      issues have been addressed systematically so far.
    

Intervention name(s): intensive monitoring
Intervention type(s): Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: diabetes mellitus; tuberculosis; management; randomized controlled trial
Comparison Of The Sacroiliac Manipulation And Kinesiological Tape In Basketball Players
Condition: Sacroiliac Joint Dysfunction
MeSH terms: Joint Diseases
Study type: Interventional

Summary: 
      In the USA, basketball is the most popular team sport for boys and girls enrolled in the
      2003-2004 school year. Many countries offer opportunities for young people to learn the game
      in a variety of settings, from physical education classes, school competitions, public and
      private sports organizations to community entertainment programmes. While the USA has long
      been seen as the dominant power in basketball, recent results in competitions such as the
      1988 and 2004 Men's Olympic Games and 2002 World Championships show the rest of the world is
      closing the gap. Basketball continues to spread around the world, thanks to ongoing
      development programs for children and youth .
    

Detailed description: 
      One of the important parameters of postural control during landing after jump is
      stabilization time. There are several studies proving the curative effect of kinesio taping.
      However, studies investigating the effect of sacroiliac chiropractic manipulation are more
      limited than kinesio taping studies. There are fewer studies evaluating the performance of
      trait juvenile basketball players. Although there is evidence showing the effect of
      manipulation on performance, Botelho et al. state that scientific evidence in this area is
      lacking.
    

Intervention name(s): manual therapy; Kinesiology taping
Intervention type(s): Other; Other
Intervention description(s): The leg length was measured while the subjects were lying on their stomachs. Then, by grasping the lateral malleolus, the knees are bent 90 degrees and changes in leg length were observed, the positions of the SI joints were noted. Afterwards, the person; As part of the tape (kinesio tex brand) kinesio protocol used in this study, the starting position of the kinesio tape is the site of lumbar spine flexion. Kinesio tape was applied transversely to the bilateral sacroiliac joint area as a long I-shaped piece of tape with 80% tension and no tension was applied to the ends of the tape. Another short tape will be adhered to the SI joint with 80% tension at a right angle to the hip, and no tension is applied to the ends of the tape.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: balance; jump
E-mental Health Support for Rural Areas
Condition: Depression
MeSH terms: Depression; Depressive Disorder
Study type: Interventional

Summary: 
      In the treatment of depression, primary care team play an important role, but they are most
      effective when inserted into a collaborative model of disease management.

      Hypotheses:Depressed patients treated in rural primary care clinics participating in a
      e-mental heath collaborative programme to manage depression achieve at least 20% better
      recovery rates in comparison with the control group three months after the baseline
      assessment.

      Goal: to compare the effectiveness of a e-mental health collaborative programme with usual
      care in rural primary-care clinics.

      Methodology: a clinical trial with two arms will be conducted in 13 community rural hospitals
      in Chile. The active group will participate in a collaborative programme between primary care
      teams and specialized teams, with support from an electronic platform and a call center.The
      control group will receive usual care, according to the Ministry of Health's Guidelines to
      Depression.To evaluate inclusion criteria -depressive patients aged between 18 and 70 years-
      and exclusion criteria -current in treatment for depression- an interview will be used that
      will include the Mini-International Neuropsychiatric Interview (MINI) to evaluate depression
      .The principal outcome will be depressive symptoms measured with the Beck Depression
      Inventory (BDI-I), and secondary outcome quality of life measured with the Health Survey
      (SF-36) at three and six months after baseline assessment.To detect a difference of 20%, in a
      one-sided model, with an alpha of 5% and power of 80%, would require 152 depressed persons
      (76 to intervention and 76 to control group).A design effect of 1.35 based on an Intraclass
      Coefficient Correlation (ICC) of 0,03839 and 13 clinics were considered. After applying the
      design effect the sample needed increased to 206 depressed persons. Considering a retention
      rate of approximately 85% 237 depressed cases will be needed.

      A program of this kind may be useful to assist primary care teams in remote areas of the
      country, in order to improve treatment outcomes for depression that is currently addressed at
      the primary care level.
    


Intervention name(s): e-mental health collaborative programme; Usual Care
Intervention type(s): Behavioral; Other
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Primary health care; Computer communication network; Depression
Dapagliflozin in Type 1 Diabetes
Condition: Fasting Glucose; Glucose Excursion; Glycemic Control
MeSH terms: Diabetes Mellitus, Type 1
Study type: Interventional
Phase: Phase 4

Summary: 
      Dapagliflozin is a highly selective, reversible and potent inhibitor of the
      sodium-glucose-linked Transporter 2 (SGLT2), which was successfully investigated for its use
      as a treatment option in type 2 diabetes mellitus. The effect of dapagliflozin is an
      increased glucosuria, and it was shown that mean blood glucose concentrations and
      postprandial glucose excursion in special were significantly reduced in type 2 diabetic
      patients. Due to its mechanism-of action it seems likely that also type 1 diabetic patients
      will benefit from dapagliflozin. The present study is focused on the effects of dapagliflozin
      on fasting glucose homeostasis and postprandial glucose excursion in male type 1diabetic
      patients. Participants will subsequently receive 10 milligrams of dapagliflozin and placebo
      for 3 days (equals 2 x 30mg per cross-over period) in a double-blind, randomised, cross-over
      design. The effects will be measured via euglycemic hyperinsulinemic clamp studies (fasting
      glucose homeostasis) and euglycemic oral glucose tolerance clamp tests (postprandial glucose
      excursions).
    


Intervention name(s): Dapagliflozin
Intervention type(s): Drug
Intervention description(s): euglycemic hyperinsulinemic clamp tests and euglycemic oral glucose tolerance clamp tests after the short-term (i.e.: 3 days, equals 10mg / 24h) intake of dapagliflozin
Intervention MeSH terms: Dapagliflozin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: dapagliflozin; fasting glucose; postprandial glucose excursion; euglycemic hyperinsulinemic clamp; euglycemic oral glucose tolerance test
The Effect of UV-Irradiation on Cutaneous Cicatrices
Condition: Skin Cicatrices
MeSH terms: Cicatrix
Study type: Interventional

Summary: 
      The purpose of this study is to examine the effect of UV-irradiation on human cutaneous
      cicatrices by clinical examinations and histological, immunohistochemical and biochemical
      analyses.
    


Intervention name(s): ultraviolet light
Intervention type(s): Device
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single
Primary purpose: Prevention
Muscle Elastography in Spastic Cerebral Palsy
Condition: Unilateral Spastic Cerebral Palsy
MeSH terms: Muscle Spasticity; Cerebral Palsy
Study type: Observational

Summary: 
      To date, clinical tests are unable to differentiate between the cause of muscle stiffness,
      although a manual instrumented spasticity assessment for the lower limb that utilizes surface
      electromyogram has recently been proposed. This study intends to use shear wave elastography
      to assess individual muscle stiffness parameters and the individual response to botulinum
      toxin injection in the elbow and wrist flexors. Collection of baseline spasticity parameters
      could then be used to predict the effect of botulinum toxin type A and ultimately serve as a
      basis for development of a treatment model for muscle spasticity in patients with spastic
      cerebral palsy.
    


Intervention name(s): Botulinum toxin type A
Intervention type(s): Drug
Intervention description(s): Botox injection in upper extremity for spasticity in pediatric CP patients
Intervention MeSH terms: Botulinum Toxins; Botulinum Toxins, Type A; abobotulinumtoxinA
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with unilateral spastic CP with presence of dynamic muscle spasticity in the elbow
        and/or wrist flexors, who will be able to provide consent. Consent may be obtained from a
        parent or legal guardian, as applicable.
Excretion of Radiolabelled AZD0837
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This is an explorative study and the scientific question to be investigated in this study is
      if AZD0837 and/or its metabolites AR-H069927XX and AR-H067637XX and other unknown metabolites
      are excreted into the bile.
    


Intervention name(s): AZD0837
Intervention type(s): Drug
Intervention description(s): Oral solution, dosing through the Loc-I-Gut catheter, single dose
Intervention model: Single Group Assignment
Masking: None (Open Label)
Keywords: pharmacokinetics
Use of Radiofrequency Ablation for RGB Salvage
Condition: Obesity
Study type: Interventional

Summary: 
      The present study will assess the feasibility of using endoscopic radiofrequency ablation
      (RFA) to treat the gastric pouch and stoma with the intent to cause tissue contraction and
      decreased compliance after a failed Roux-en-Y gastric bypass.
    

Detailed description: 
      Obesity is a leading cause of preventable death in the United States, with approximately
      300,000 related deaths per year. The most commonly performed bariatric surgical interventions
      are Roux-en Y gastric bypass (RGB) and laparoscopic adjustable gastric band placement.
      Despite the overall initial success of RGB to induce significant EBWL in the majority of
      patients, significant weight regain occurs in about 25% of patients at 2+ years following
      surgery. Given the preliminary success of endoscopic, non-surgical salvage interventions for
      the failed (uncomplicated) RGB patient, the present study will assess the feasibility of
      using endoscopic radiofrequency ablation (RFA) to treat the gastric pouch and stoma with the
      intent to cause tissue contraction and decreased compliance. A reduction of size and
      compliance may, as others have reported, result in re-establish weight loss and achieve an
      acceptable EBWL with minimal patient morbidity.
    

Intervention name(s): RFA treatment
Intervention type(s): Device
Intervention description(s): If eligible for enrollment, a focal ablation device is selected as an intervention(size according to physician preference) and mounted on the end of the endoscope and introduced via the mouth into the esophagus and gastric pouch. The gastric pouch is treated from the top of the gastric folds to and just through the stomal anastomosis.
Other intervention name(s): HALO60, HALO90, HALO90 Ultra
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: RGB Salvage, RFA
The Risk of Uncomplicated Peptic Ulcer in a Cohort of Secondary Prevention Aspirin Users
Condition: Uncomplicated Peptic Ulcer
MeSH terms: Peptic Ulcer; Ulcer
Study type: Observational

Summary: 
      This study is conducted in a cohort of low dose aspirin (ASA) users previously ascertained.
      The aims of the post hoc analyses are:

      To estimate the incidence of uncomplicated peptic ulcer (UPU) in a cohort of low-dose ASA for
      secondary prevention of vascular disease and the relative risk of UPU associated with use and
      discontinuation of use of low dose ASA.

      To estimate the effect of proton pump inhibitors (PPI) on the occurrence of UPU among users
      of low-dose ASA for secondary prevention of vascular disease To evaluate the effect of other
      risk factors on the occurrence of UPU among users of low-dose ASA for secondary prevention of
      vascular disease.
    

Detailed description: 
      The risk of uncomplicated peptic ulcer in a cohort of secondary prevention aspirin users
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Patients aged 50-84 yrs who had a first prescription of low-dose ASA (75-300mg/day) for
        secondary cardiovascular or cerebrovascular prevention in 2000-2007 in The Health
        Improvement Network database in the UK. Patients had to be enrolled with their PCP (Primary
        Care Physician) for at least 2 years and have a health contact in the year prior. Patients
        with use of aspirin ever recorded in the database before start of follow-up as well as
        patient with cancer or alcohol abuse were excluded. Individuals were followed up until the
        earliest occurrence of one of the following endpoints; first recorded diagnosis of
        uncomplicated peptic ulcer, canser, alcohol abuse or alcohol related disease, reaching the
        age of 85 years old, date of last practice data collection, death or end of follow-up ( 30
        September 2011).Patient records were manually reviewed to validate cases.
      
Keywords: Uncomplicated peptic ulcer; Acid-suppressing drugs; Epidemiology
Treatment of Great Saphenous Vein Varicosities
Condition: Varicose Veins
MeSH terms: Varicose Veins
Study type: Interventional

Summary: 
      Venous insufficiency at lower extremities may result in clinical problems from cosmetic
      issues to ulcerations. When the frequency of venous insufficiency and its related problems
      are considered besides their diversity, it is encountered as a public health issue. This
      pathology is reported to affect 40% of women and 20% of men.1 Patients with varicose veins
      may complain of unsightly appearance, aching, heaviness, pruritus, and early fatigue of the
      affected leg. These symptoms worsen with prolonged standing and sitting and are relieved by
      elevation of the leg above the level of the heart. Also, mild edema is often present. More
      severe signs include thrombophlebitis, hyperpigmentation, lipodermatosclerosis, ulceration,
      and bleeding
    


Intervention name(s): Endovenous chemical ablation with Trendelenburg's operation (eCAT)
Intervention type(s): Procedure
Intervention description(s): Endovenous chemical ablation with trendelenburg's operation (e CAT) is a method for the treatment of varicose veins
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of Caffeine on Myocardial Oxygenation
Condition: Caffeine
Study type: Interventional

Summary: 
      The purpose of this study is to investigate the impact of caffeine on myocardial oxygenation
      and other cardiovascular magnetic resonance parameters in healthy controls.
    

Detailed description: 
      Caffeine is presumed to create a confounder with diagnostic imaging. The vasodilatory
      capacity is considered a key measure for the detection of significant coronary disease with
      stenosed epicardial arterial conduit vessels and overall microvascular function, including
      endothelial dysfunction. Twenty nine healthy controls will undergo a baseline cardiovascular
      magnetic resonance (CMR) exam. Afterwards, participants will consume coffee in the presence
      of study personnel. This will consist of 3 espresso shots, which will be consumed within 15
      minutes. Approximately 2h after coffee consumption the CMR exam will be repeated. The goal
      will be to investigate the impact of caffeine on myocardial features. In particular the
      effect on the myocardial oxygenation response to vasodilating and vasoconstricting stimuli.
    

Intervention name(s): Caffeine
Intervention type(s): Other
Intervention description(s): Consumption of 3 shots of espresso
Other intervention name(s): Coffee
Intervention MeSH terms: Caffeine
Intervention model: Single Group Assignment
Intervention model description: Controlled before-after comparison
Masking: None (Open Label)
Primary purpose: Other
Keywords: CMR; Myocardial oxygenation; Myocardial Function; Coffee
A Clinical Trial to Demonstrate the Efficacy and Safety of Cenestin 0.3 mg for the Treatment of Hot Flashes
Condition: Hot Flashes
MeSH terms: Hot Flashes
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a randomized, double-blind study to compare the efficacy and safety of daily doses of
      Cenestin 0.3 mg tablets to placebo in reducing the frequency and severity of moderate to
      severe hot flashes in postmenopausal women.
    

Detailed description: 
      The overall study duration will be approximately 16 weeks. After a screening/baseline period
      of up to 4 weeks patients will be randomized to receive either placebo tablets or Cenestin
      0.3mg tablets
    

Intervention name(s): Cenestin 0.3 mg Tablets; Placebo
Intervention type(s): Drug; Other
Intervention description(s): 1 tablet daily; 1 tablet daily
Other intervention name(s): Synthetic conjugated estrogens, A; Placebo tablets
Intervention MeSH terms: Estrogens; Estrogens, Conjugated (USP); Estrogens, conjugated synthetic A
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: menopause; vasomotor symptoms