Effect of Interval Cancer and Screening Process on Survival and Disease-free Period in Breast Cancer
Condition: Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Observational

Summary: 
      This is a multicenter retrospective cohort of women participating in breast cancer screening
      programs in Spain between 2000 and 2009, with a cancer diagnosed during the screening or
      between the screening interval (interval cancer), specifically true interval cancers and
      false negatives. The investigators obtained woman-related information (including breast
      density), tumor-related information (including tumor phenotype), and follow-up information
      (including relapses, second neoplasms and vital status at the end of follow up (June 2014)).
      The objective is to evaluate the survival and disease-free period of women participating in
      screening programs for breast cancer with a cancer diagnosed during the screening or an
      interval cancer, specifically true interval cancers and false negatives.

      This study is part of a broader project (CAMISS study), which also includes one prospective
      cohort (CAMISS Prospective cohort - Identifier in ClinicalTrials.gov: NCT02439554).
    

Detailed description: 
      The general objective for this study is to evaluate the survival and disease-free period of
      women participating in screening programs for breast cancer with a cancer diagnosed during
      the screening or an interval cancer, specifically true interval cancers and false negatives.

      The cohort has information of women participating in breast cancer screening programs in
      Spain between 2000 and 2009, with a breast cancer diagnosed during the screening or between
      the screening interval (interval cancer), specifically true interval cancers and false
      negatives. The investigators obtained woman-related information (including breast density),
      tumor-related information (including tumor phenotype), and follow-up information (including
      relapses, second neoplasms and vital status at the end of follow up (June 2014)).

      Expected results: Nowadays there are no results of cohort analysis of the diagnostic process
      of care that integrates all those different aspects. This study will complement the
      evaluation of population screening, specifically the interval cancer and the impact on
      survival and disease-free period taking into account relevant variables like breast density,
      tumor phenotype, clinical complications, readmissions, and the surgical approach.

      This study is part of a broader project (CAMISS study) coordinated by the Evaluation of
      Health Services of Epidemiology and Public Health Group, which consists of two cohorts of
      women diagnosed with breast cancer: a prospective cohort (n=2,040 incident cases of breast
      cancer diagnosed in 18 hospitals of 5 Spanish regions) (Identifier in ClinicalTrials.gov:
      NCT02439554) and a retrospective cohort of screened women diagnosed with breast cancer
      between 2000 and 2009 in two Spanish regions (n=1,086).

      The general objective of the CAMISS study is to evaluate different aspects of health care
      received by patients with breast cancer like the diagnostic process, treatment,
      complications, survival, costs and quality of life to provide information to improve the
      effectiveness and cost-effectiveness of interventions, reduce variability, have better
      predictive rules and increase the quality of life.
    

Intervention name(s): Mode of detection: Cancer detected at screening; Mode of detection: Interval cancer
Intervention type(s): Procedure; Procedure
Intervention description(s): Cancers detected as a result of screening mammograms.; Cancers diagnosed after a negative screening mammogram and before the next screening invitation (2 years in Spain)
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Women screened for breast cancer and diagnosed for breast cancer in the screening program
        (screen-detected cancer) or within the interval between 2 screening rounds (interval
        cancer)
      
Keywords: Breast cancer, screening, survival