bioihbjkbjnl/mcl2 huggingface dataset:
The Relative Prevalence and Severity of Autonomic Nervous System Dysfunction
Condition: Cardiovascular Autonomic Neuropathy; Diabetic Autonomic Neuropathy; Autonomic Dysfunction
MeSH terms: Peripheral Nervous System Diseases; Autonomic Nervous System Diseases; Primary Dysautonomias; Nervous System Diseases; Diabetic Neuropathies
Study type: Observational

Summary: 
      The purpose of this study is to measure the prevalence and severity of cardiac autonomic
      neuropathy (CAN), diabetic autonomic neuropathy (DAN) which in non-diabetics is termed
      advanced nervous system (ANS) dysfunction, and autonomic dysfunction as well as the overall
      sympathovagal balance (SB) in the CEFH population of diabetic patients versus non-diabetic
      patients undergoing elective vitreoretinal surgery.
    

Detailed description: 
      The purpose of this study is to measure the prevalence and severity of cardiac autonomic
      neuropathy (CAN), diabetic autonomic neuropathy (DAN) which in non-diabetics is termed
      advanced nervous system (ANS) dysfunction, and autonomic dysfunction as well as the overall
      sympathovagal balance (SB) in the CEFH population of diabetic patients versus non-diabetic
      patients undergoing elective vitreoretinal surgery.
    

Intervention name(s): ANSAR ANX 3.0 Software
Intervention type(s): Other
Intervention description(s): Three values are calculated by the ANSAR ANX 3.0® software of the spectral analysis of HRV and respiration:
RFa an indicator of parasympathetic function with normal values between 0.5 and 10 bpm2;
LFa an indicator of sympathetic function also with normal values between 0.5 and 10 bpm2;
SB or the ratio of LFa/RFa with normal reference values of 0.4 to 3.0.
The ANSAR ANX 3.0® software defines three different levels of autonomic neuropathy (autonomic dysfunction) as follows (see Figure 1):
Cardiovascular Autonomic Neuropathy (CAN): resting parasympathetic insufficiency (not enough parasympathetic protection for the heart) or RFa < 0.1 bpm2.
Diabetic Autonomic Neuropathy (DAN), or advanced autonomic dysfunction in non-diabetics, is defined as low autonomics: LFa < 0.5 bpm2 or 0.1 < RFa < 0.5 bpm2.
Autonomic Dysfunction: normal resting LFa and RFa, but low LFa response to Valsalva or low RFa response to deep breathing.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The study population will consist of patiented from the Callahan Eye Foundation.
      
Keywords: Cardiovascular Autonomic Neuropathy; Diabetic Autonomic Neuropathy; Autonomic Dysfunction
Massage Therapy in Treating Patients With Cancer Pain
Condition: Pain; Unspecified Adult Solid Tumor, Protocol Specific
Study type: Interventional
Phase: Phase 2

Summary: 
      RATIONALE: Massage therapy may help lessen pain caused by cancer.

      PURPOSE: This randomized phase II trial is studying how well massage therapy works in
      treating patients with cancer pain.
    

Detailed description: 
      OBJECTIVES:

        -  Determine whether the effects of massage therapy in patients with cancer pain are
           sufficiently promising to warrant a definitive trial.

        -  Determine the feasibility of a definitive trial.

      OUTLINE: This is a randomized, controlled, pilot study. Patients are stratified according to
      in-patient status (yes vs no) and first baseline pain score ≥ 7 (yes vs no). Patients are
      randomized to 1 of 3 treatment arms.

        -  Arm I (massage therapy): Patients receive a light touch ("Reiki") massage over 45
           minutes.

        -  Arm II (volunteer visit control): Patients receive a 45-minute visit from a trained
           volunteer who will be available to sit quietly or talk with the patient to discuss
           issues of concern, as desired by the patient. Volunteers will not touch the patient
           except to pat their shoulder or briefly hold their hand.

        -  Arm III (quiet time control): Patients receive 45 minutes of quiet time. Pain and mood
           are assessed at baseline, immediately after treatment, at 6 hours and 24 hours after
           treatment, and then daily for the next 5 days after treatment.

      PROJECTED ACCRUAL: A total of 60 patients will be accrued for this study.
    

Intervention name(s): massage therapy; visit with a volunteer; period of quiet time; questionaire about pain
Intervention type(s): Other; Other; Other; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: unspecified adult solid tumor, protocol specific; pain
Microsoft Kinect, Gait Function,Hemineglect, Vestibulo-ocular Training
Condition: Hemiplegic Gait
MeSH terms: Gait Disorders, Neurologic
Study type: Interventional

Summary: 
      Gait problems in hemineglect patient post stroke , vestibuloocular training plays a role in
      improving gait function, gait assessment using a model based study (Microsoft Kinect) for pre
      and post training assesment.
    

Detailed description: 
      The syndrome of visuospatial neglect is a common consequence of unilateral brain injury. It
      is most often associated with stroke and is more severe and persistent following right
      hemisphere damage, with reported frequencies in the acute stage of up to 80%. This may result
      in gait disturbance, high levels of energy expenditure and increase the risk of falls.
      Vestibuleo-ocular training techniques are aimed at improving or even restoring visual
      function by training patients to detect stimuli in the blind hemifield and increase their
      overall sensitivity to them. The investigators propose a model based (Microsoft Kinect), a
      device can be used for assessment of spatiotemporal gait variables as well as gait
      kinematics.
    

Intervention name(s): vestibuloocular training; regular exercise training for hemiplegic patients
Intervention type(s): Other; Other
Intervention description(s): using vestibulo ocular training program for training neglect patient; Traditional gait training program.
Other intervention name(s): regular exercise training for hemiplegic patients
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
The Importance of Exercise to Prevent Injuries in Athletes
Condition: Injury;Sports
MeSH terms: Wounds and Injuries; Athletic Injuries
Study type: Interventional

Summary: 
      Introduction: running is one of the most accessible and practiced sports in the world since
      the 21st century. Unfortunately, the incidence of injuries in the population that practices
      it is high regardless of experience, although the risk of injury increases in amateur
      runners. One of the main keys to reduce the incidence of running related injuries may be to
      improve the ability to reduce the load or impact. For this, there are different strategies
      such as a gradual increase in the load to run, and exercise within which is muscle
      strengthening and balance training or proprioception.

      Objective: to verify the effectiveness of a program of proprioceptive exercises based on the
      static and dynamic balance for the reduction of lower limb injuries in amateur runners during
      the competition season.
    

Detailed description: 
      Methodology: 66 amateur runners, after simple size calculation, will be randomized into two
      groups. Experimental group will carry out the proprioceptive exercise program during 8 weeks
      at the begining of the season and control group will continue with their usual training
      routine. The main variable running related injury will be collected weekly during the
      follow-up.

      Results: When all the data needed for the study has been collected, researchers gathers
      results and exports them for statistical interpretation.
    

Intervention name(s): Proprioceptive exercise program; Usual training routine
Intervention type(s): Other; Other
Intervention description(s): Group A will carry out two sessions of proprioceptive training per week, in a total of 8 weeks, during the pre-season period (September-October). Each session will last approximately 30 minutes and will include 6 exercises. The execution of the exercises will be supervised by a physiotherapist and a national trainer of athletics.; The subjects of the control group (group B) will be informed so that they do not include any change in their usual training routine.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: proprioception; running; prevention; injuries
Intravenous Ascorbic Acid Administration in Hysterectomy
Condition: Abdominal Hysterectomy
Study type: Interventional
Phase: Phase 3

Summary: 
      vitamin C or ascorbic acid has known role in tissue repair. due to it's
      properties(water_soluble), vitamin c is not stored in the body and when depleted, the
      bleeding tendency will increase due to dysfunctional connective tissues production in vessel
      wall and it has some important functions in platelets.
    

Detailed description: 
      In this randomized clinical trial, 1000 mg vitamin C will administrate intravenously a day
      before surgery and during surgery in patients who undergo abdominal hysterectomy.
    

Intervention name(s): vitamin C
Intervention type(s): Drug
Intervention description(s): water-soluble vitamin C injection contain of 1000 mg vitamin C that given via intravenous injection
Other intervention name(s): ascorbic acid
Intervention MeSH terms: Ascorbic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: vitamin c; Hysterectomy; bleeding; wound healing; abdominal surgeries
Effects of a Low Glycemic Load Diet on Fatty Liver in Children
Condition: Hepatic Steatosis
MeSH terms: Fatty Liver
Study type: Interventional

Summary: 
      There has been a recent increase in incidence of obesity and its associated morbidities,
      including T2 DM, hypertension and hepatic steatosis. Hepatic steatosis is a precursor to
      non-alcoholic steatohepatitis, cirrhosis and end-stage liver disease. The 1st reported case
      of pediatric hepatic steatosis was in 1980 and it is now affects 30-77% of overweight
      children. In addition to its association with obesity, hepatic steatosis has been associated
      with the metabolic syndrome, insulin resistance, and post-prandial hyperglycemia. Current
      treatment of hepatic steatosis includes weight loss with a hypocaloric low fat diet. Given
      the association with insulin resistance and post-prandial hyperglycemia, adult patients with
      hepatic steatosis that does not respond to weight loss are placed on insulin sensitizing
      drugs. We hypothesize that weight loss with a diet designed to decrease insulin resistance
      and post-prandial hyperglycemia, a low glycemic load diet, will provide a safe and effective
      way to decrease hepatic fat content in the pediatric population. This hypothesis will be
      tested with a randomized control trial comparing the effect of a low fat diet with a low
      glycemic load diet.
    


Intervention name(s): Low glycemic load diet; Low fat diet
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Outpatient behavioral counseling; Outpatient behavioral counseling
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: non-alcoholic fatty liver disease; steatohepatitis; overweight; insulin resistance
Bipolar Scissors for Circumcision
Condition: Male Circumcision
Study type: Interventional

Summary: 
      comparing the outcomes of using bipolar scissors for male circumcision to the classic scalpel
      method
    

Detailed description: 
      A prospective, randomized study, comparing two different techniques for pediatric male
      circumcision: the bipolar diathermy scissors technique with that of a classic scalpel
      technique. Study included male infants from 40 days old up to 18 month old. They were
      reviewed regarding Operative time, bleeding, complications, postoperative pain and morbidity.
      Differences in the outcome were compared.
    

Intervention name(s): Bipolar scissors; classic scalpel
Intervention type(s): Procedure; Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Comparing Outcomes of two different surgical techniques between two groups
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: bipolar; scalpel; foreskin; prepuce
The Influence of 5-HTTLPR and BDNF Polymorphisms on Anxiety and Mood After Acute Exercise
Condition: Polymorphisms; Exercise; Mood
Study type: Interventional

Summary: 
      The Influence of 5-HTTLPR and BDNF Polymorphisms on Anxiety and Mood After Acute Exercise.

      Introduction: The 5-HTTLPR (SLC6A4) and BDNF (Val66Met) polymorphism presents an action on
      the modulation of human behavior and has received great attention as a risk factor for
      several psychiatric disorders. In recent years, a growing number of studies have evaluated
      the association between these polymorphisms and personality traits related to anxiety and
      depression. Objectives: To determine the frequencies of 5-HTTLPR and BDNF polymorphisms in a
      college students population; To determine the influence of 5-HTTLPR and BDNF polymorphisms on
      mood states and anxiety after acute physical exercise. Material and Methods: Four hundred
      (400) College students will be assessed.

      In the first phase of the study, the following procedures will be performed: Screening,
      Aerobic Fitness Assessment (Step Test), Questionnaires (PAR-Q, Habitual Physical Activity
      Level, Beck Anxiety and Depression Scale, State-Trait Anxiety, and Perceived Stress Scale),
      blood sample collection and genotyping. In the second phase of the study, two (2) groups with
      or without polymorphisms will be selected (for each gene). These groups will be submitted to
      four conditions (three experimental conditions and one control condition), carried out
      randomly and separated by an interval of 1 week. In the experimental Conditions the
      volunteers will perform treadmill exercises sessions (30 minutes) in three different
      intensities (light, moderate and vigorous) and will respond to the Borg Scale at 10, 20 e 30
      minutes. In the control condition the volunteers will be instructed to remain seated (quiet
      rest), relaxed and silent for 30 minutes. In both conditions, the volunteers will complete
      the Profile of Mood States (POMS) and State-Anxiety (STAY), 05 (five) minutes before and, 5
      (five) and 20 (twenty) minutes following the interventions.
    


Intervention name(s): Exercise; Quiet rest
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Three exercises sessions - 30 min (light: 45 - 50%, moderate: 65 -70% and vigorous: 85 - 90% Heart Rate Maximal).; Quiet rest during 30 min
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Screening
Keywords: Anxiety; Mood; Physical activity; Polymorphisms
Study Comparing Etanercept 50 mg Once Weekly to 25 mg Twice Weekly in Patients With Ankylosing Spondylitis
Condition: Ankylosing Spondylitis
MeSH terms: Spondylitis; Spondylarthritis; Spondylitis, Ankylosing
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to compare efficacy, pharmacokinetics, and safety of
      investigational formulations of etanercept administered as 50 mg once weekly with 25 mg twice
      weekly and placebo in patients with ankylosing spondylitis (AS).
    


Intervention name(s): Etanercept
Intervention type(s): Drug
Intervention MeSH terms: Etanercept
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
A Study for Participants With Type 2 Diabetes Mellitus
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 2

Summary: 
      This drug is being evaluated for possible treatment of type 2 diabetes mellitus.
      Participation in this study is expected to last up to 18 weeks. A goal of this study is to
      determine the safety and effectiveness of LY2409021.
    


Intervention name(s): LY2409021; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 4 capsules by mouth taken once daily for 12 weeks; 4 capsules by mouth once daily for 12 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Diabetes Mellitus, Type 2
The Efficacy and Safety of the Loading Dose of Tranexamic Acid in Scoliosis Surgery During Perioperative
Condition: Tranexamic Acid
MeSH terms: Scoliosis
Study type: Observational

Summary: 
      This study intends to make full use of the advantage of spinal orthopedic surgery in our
      medical center.Analyze the blood loss and blood coagulation function and the influence of
      safety of load dose tranexamic acid (TXA) in scoliosis surgery during perioperative.
    


Observational model: Other
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        age:18-60 years old；American Society of Anesthesiologists (ASA):I-II；The spinal orthopedic
        undergoing elective surgery
      
Keywords: tranexamic acid; Blood conservation
Comparing a New Technique of Combining Carbon-dioxide With Electrocautery With Usual Technique of Stand-alone Electrocautery for Taking Down Left Internal Mammary Artery for Coronary Artery Bypass(CABG)
Condition: Coronary Artery Disease; Coronary Artery Disease With Myocardial Infarction
MeSH terms: Coronary Artery Disease; Myocardial Ischemia; Coronary Disease; Myocardial Infarction; Infarction
Study type: Interventional

Summary: 
      The goal of this study is to compare the efficacy of a new harvesting technique for an
      arterial conduit(LIMA - Left Internal Mammary artery) in patients undergoing Coronary artery
      bypass grafting. The researcher will compare the

        1. Time taken to harvest the artery

        2. Flow of blood between the two techniques
    

Detailed description: 
      Following consultation to our department, after a detailed history and clinical
      examination,patients with CAD, being planned for CABG, will be subjected to a detailed pre-op
      Echocardiogram and coronary angiogram. After necessary pre-op assessment, patient will be
      taken up for the surgery. Invasive monitoring will be done.

      Following dissection of LIMA by the above mentioned technique, flow of blood from the
      harvested LIMA, for one whole minute is noted. The operative time required for the dissection
      of LIMA will be noted and entered.

      The data between the two techniques will be compared statistically.
    

Intervention name(s): Modified Carbo-dissection Technique; Conventional Arm
Intervention type(s): Procedure; Procedure
Intervention description(s): This technique comes the C02 blower with electrocautery. Thereby, producing vasodilatation due to the gas and dissection aided by the electrocautery.; This technique uses only the electrocautery as conventional model
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The interventional group was compared with the conventional group in terms of two parameters : 1) operative time 2) blood flow/min
Masking: None (Open Label)
Primary purpose: Other
Keywords: CABG, LIMA harvesting, CAD
Adaptive Strategies for Resilient Intrinsic Self-Regulation in Extremes (RISE)
Condition: Chronic Pain
MeSH terms: Chronic Pain
Study type: Interventional

Summary: 
      The purpose of this study is to assess the efficacy of a resilience intervention in Veterans
      with chronic pain compared to wait list control.
    

Detailed description: 
      After being consented and screened for eligibility, participants completed baseline
      assessments and then were randomized to either the study intervention or wait list control.
      Participants who were randomized to the study intervention completed post testing assessment
      measures within two weeks of the final treatment. Participants who were randomized to
      waitlist conditions completed post testing assessment measures within 2 weeks of the end of
      the waitlist condition and then subsequently received the study intervention.
    

Intervention name(s): Resilient Intrinsic Self-Regulation Strategies in Extremes
Intervention type(s): Behavioral
Intervention description(s): The manualized intervention covered resilience strategies organized into four modules: (1) engagement, (2) social relatedness, (3) transformation of pain and (4) building a good life. The modules were delivered in 8 weekly sessions of 90 minutes each.
Other intervention name(s): Active Intervention arm
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Ceramic Versus Composite in the Treatment of Posterior Teeth by Inlays or Onlays
Condition: Dental Caries; Inlays
MeSH terms: Dental Caries
Study type: Interventional
Phase: Phase 3

Summary: 
      The main purpose of this trial is to determine which material, between ceramic and composite,
      is best to manufacture dental inlays and onlays in the treatment of moderate dental substance
      losses, generally due to dental caries. Restorations will be done using direct Computer
      Assisted Design and Manufacturing (CAD-CAM). Another aim of this study is to determine which
      factors influence the success of these restorations.
    

Detailed description: 
      WHO estimates dental caries prevalence to be over 90% adults worldwide. When tooth substance
      loss due to the decayed tissue is small, a filling is done by the dentist directly. When the
      substance loss is important, dentists often treat it with a crown, which presents the
      disadvantage of further mutilating the tooth. An intermediate technique consists in
      manufacturing an inlay or an onlay: these restorations become more and more common since they
      are a minimally invasive solution in such cases. Inlays and onlays can be made of metal,
      ceramic or composite. Patients tend to refuse metallic restorations, so that dentists
      generally have to choose between composite and ceramic. Composite wears whereas ceramics
      fracture. Published in vitro studies provide possible answers to which material is most
      effective but very few clinical studies have been conducted to confirm them. Material\'s
      choice for inlay manufacturing is thus more country-based than evidence-based (Most french
      dentists choose composite while US dentists prefer ceramics for example). The main objective
      of this trial is to compare the clinical performance of ceramic and composite inlays/onlays.
      Other objectives include looking for the prognostic factors of these restorations and
      validating the criteria proposed by the World Dental Federation (FDI) to evaluate dental
      restorations.
    

Intervention name(s): ceramic (Empress CAD, Ivoclar Vivadent); composite (Lava Ultimate, 3M Espe)
Intervention type(s): Device; Device
Intervention description(s): Leucite-reinforced glass ceramic (Empress CAD, Ivoclar Vivadent); Nanohybrid composite resin (Lava Ultimate, 3M Espe)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Dental caries; inlays; composite resins; IPS-Empress ceramic; bicuspid; FDI dental restorations evaluation criteria