Dexmedetomidine vs. Remifentanil Undergoing Cataract Surgery in Geriatrics
Condition: Geriatrics; Outpatients; Personal Satisfaction
MeSH terms: Cataract
Study type: Interventional

Summary: 
      Dexmedetomidine is an α2-adrenergic receptor agonist used for its sympatholytic effect,
      providing sedation, analgesia, and cardiovascular stabilization in the perioperative period.
      Remifentanil is a µ opioid agonist with a rapid onset and short duration of action, which is
      degraded by plasma esterase in tissues. Investigators aimed to compare the effects of
      dexmedetomidine and remifentanil infusions on sedation quality, side effects, and surgeon's
      satisfaction in geriatric outpatients who underwent cataract surgery.
    

Detailed description: 
      Dexmedetomidine is an α2 agonist and remifentanil is a short-acting μ, opioid agonist. The
      aim of this study was to compare dexmedetomidine and remifentanil infusions used for
      conscious sedation in geriatric patients undergoing outpatient cataract surgery in terms of
      sedation quality, hemodynamic stability, and surgeon satisfaction.

      Eighty patients were divided into two groups according to the administration of
      dexmedetomidine (Group D) and remifentanil (Group R) infusion in this randomized,
      prospective, double-blinded study. In group D (n = 40), after a loading of 1 µg/kg
      dexmedetomidine in 10 minutes, 0.4 µg/kg/h-1 infusion was administered. In Group R (n = 40),
      remifentanil at a dose of 0.05 µg/kg-1 was administered for 10 minutes, and then 0.05
      µg/kg/min-1 infusion was continued.
    

Intervention name(s): Dexmedetomidine infusion; Remifentanil infusion
Intervention type(s): Drug; Drug
Intervention description(s): After Dexmedetomidine infusion was given for 10 minutes, local anesthesia was applied by the surgeon. Peribulbar block and periorbital infiltration application were performed by applying a mixture of lidocaine (Jetokain, Adeka, Turkey) and 1/200000 adrenaline. After the local anesthetic agent was applied by the surgeon, orbital compression was provided for 5 minutes with maximum pressure to block the eyelid movements. Cataract surgery procedures of all patients included in the study were performed by the same surgeon.; After Remifentanil infusion was given for 10 minutes, local anesthesia was applied by the surgeon. Peribulbar block and periorbital infiltration application were performed by applying a mixture of lidocaine (Jetokain, Adeka, Turkey) and 1/200000 adrenaline. After the local anesthetic agent was applied by the surgeon, orbital compression was provided for 5 minutes with maximum pressure to block the eyelid movements. Cataract surgery procedures of all patients included in the study were performed by the same surgeon.
Other intervention name(s): Cataract surgery; Cataract surgery
Intervention MeSH terms: Dexmedetomidine; Remifentanil
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: geriatrics; ambulatory surgery; cataract; anesthesia; conscious sedation; dexmedetomidine; remifentanil