bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Global Postural Exercises Versus Specific Therapeutic Neck Exercises in Chronic Non-specific Neck Pain
Condition: Neck Pain; Chronic Pain
MeSH terms: Chronic Pain; Neck Pain
Study type: Interventional

Summary: 
      This study is a randomized, parallel, blinded, clinical trial of treatments. The general
      objective of this study is to analyze and compare the short-term results, during a 4-week
      follow-up, of two different treatments in patients with chronic nonspecific neck pain.

      The treatments to be applied are Global Postural Reeducation (GPR) and specific therapeutic
      exercise, applied during 8 treatment sessions in 4 weeks. These treatments will be applied by
      a physiotherapist with clinical experience in the treatment of cervical pain.

      During the study, 4 evaluations will be carried out to assess the effects of the
      interventions on pain, disability, standing postural control and neuromuscular behavior of
      the cervical muscles ((1) Baseline (pre-intervention); 2) Second pre-intervention (1 week
      later); 3) 1st post-intervention after four sessions (1+2 weeks later); 4) Final, 2nd
      post-intervention (1+4 weeks later))
    


Intervention name(s): Global Postural Reeducation; Exercise Therapeutic
Intervention type(s): Other; Other
Intervention description(s): The participants will receive treatment along 4 weeks, 2 sessions per week, and 40-45 minutes each session.
In the treatment 3 of the therapeutic postures of GPR method to will carry out following Souchard's principles of "Global Postural Reeducation"; The participants will receive treatment along 4 weeks, 2 sessions per week, and 40-45 minutes each session.
The treatment will be divided into 3 phases, where it initially starts with phase 1 (3 treatments) and progresses to phase 2 (3 treatments) until reaching stage 3 (2 treatments).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Postural Global Reeducation; Exercise; Chronic neck pain; Disability; Postural Control; Cervical muscles
The Effect of Muscular Strength Training in Patients With Drug Addiction
Condition: Substance-related Disorders
MeSH terms: Substance-Related Disorders
Study type: Interventional

Summary: 
      Physical health does not have a high priority in today's treatment of patients with substance
      use disorder (SUD). SUD patients have a poor physical health not only due to injuries related
      to the substance abuse, but also because of the addiction-related lifestyle. There are few
      studies today that provide information about SUD patient's physical health, and especially
      there is little information about their muscular strength. One of the project's aims is to
      measure muscular strength in SUD patients who are being treated for their addiction, and see
      if they have decreased neuromuscular function. If so, we will investigate the effect of
      maximal strength training on neuromuscular function in these patients.
    


Intervention name(s): strength training; no training (control)
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: rehabilitation; strength training; muscle strength; physical fitness
Treatment of Chronic Urticarial Unresponsive to H1-antihistamines With an Anti-IL5Ralpha Monoclonal Antibody
Condition: Chronic Idiopathic Urticaria
MeSH terms: Urticaria; Chronic Urticaria
Study type: Interventional
Phase: Phase 4

Summary: 
      Study to determine the efficacy of benralizumab when compared to placebo in patients with
      chronic hives that do not respond to antihistamine treatment
    

Detailed description: 
      Subjects with chronic hives that do not respond to antihistamine treatment and have hives of
      unknown cause will be eligible. Subjects who meet the inclusion/exclusion criteria after the
      run-in phase will receive 3 doses of study medication. The study also involved blood draws
      and a punch biopsy of a hive
    

Intervention name(s): benralizumab; placebo
Intervention type(s): Biological; Biological
Intervention description(s): open-label treatment; sterile water to mimic benralizumab
Intervention MeSH terms: Benralizumab
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Influence of Whole Body Vibration Compared to Conventional Physiotherapy in Patients With Gonarthrosis
Condition: Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Observational

Summary: 
      40 patients with osteoarthritis of the knee will be randomly assigned to conventional
      physiotherapy on the one and whole body vibration exercises on the other hand. The duration
      of the training will be 6 weeks, three times a week.

      The outcome will be measured by WOMAC and SF-12 scores relating to pain and quality of life.
      The second outcome criteria will be a motion analysis and balance testing before and after
      the training.

      The follow-up is 26 weeks.
    


Intervention name(s): Conventional physiotherapy; Whole body vibration
Intervention type(s): Behavioral; Behavioral
Intervention description(s): 3 times weekly 30 minutes of conventional physiotherapy to strengthen muscular strength and balance in the lower extremity.; 3 times weekly 30 minutes of exercises on a whole body vibration device to strengthen muscular strength and improve muscular balance in the lower extremity.
Other intervention name(s): Galileo; Galileo Whole body vibration
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients with osteoarthritis of the knee.
      
Keywords: Galileo; Whole body vibration; Osteoarthritis; Knee; Physiotherapy
Study of TAK-816 in Healthy Infants
Condition: Immunization
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to evaluate the efficacy (immunogenicity) of TAK-816 when
      administered to healthy Japanese infants as multiple subcutaneous doses.
    

Detailed description: 
      Haemophilus Influenzae type b (Hib) is one of the major causes of infectious meningitis in
      children, and can also cause sepsis, cellulitis, arthritis, epiglottitis, pneumonia and
      myelitis.

      TAK-816 is a conjugated Hib vaccine being tested in healthy infants aged 3-6 months at the
      time of the first dose.

      The objective of this study is to evaluate the efficacy (immunogenicity) and safety of
      TAK-816 (10 ϻg/0.5 mL) in comparison with ActHIB (Haemophilus b Conjugate Vaccine) as a
      control.

      In addition, the efficacy (immunogenicity) and safety of Absorbed Diphtheria-Purified
      Pertussis-Tetanus Combined (DPT-TAKEDA) vaccine when TAK-816 and DPT vaccine are administered
      concomitantly will also be investigated.

      For the Primary Immunization Phase of this study: three doses of TAK-816 or ActHIB 10 µg/0.5
      mL and DPT-TAKEDA 0.5 mL will be administered at 4-week intervals over 8 weeks (Visit 1, 2,
      3). At4 weeks after the third dose, a follow-up observation and evaluation will be made
      (Visit 4).

      For the Booster Vaccination Phase of this study: a single dose of TAK-816 or ActHIB 10 µg/0.5
      mL and DPT-TAKEDA 0.5 mL will be given at 52 weeks after the third dose (Visit 5). At 4 weeks
      after the fourth dose, a follow-up observation and evaluation will be made (Visit 6).
    

Intervention name(s): TAK-816+ DPT-TAKEDA; ActHIB+ DPT-TAKEDA
Intervention type(s): Biological; Biological
Intervention description(s): TAK-816 0.5 mL and DPT-TAKEDA 0.5.mL, subcutaneous injections, three doses administered at 4-week intervals over 8 weeks, followed by a fourth dose 52 weeks after third dose.; ActHIB 0.5 mL and DPT-TAKEDA 0.5.mL, subcutaneous injections, three doses administered at 4-week intervals over 8 weeks, followed by a fourth dose 52 weeks after third dose.
Other intervention name(s): Vaxem Hib; Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate)
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Immunostimulation; Haemophilus b conjugate vaccine; HIB
Investigation of the Effectiveness of Muscle Inhibition and Space Correction Techniques of Kinesiotaping Method in Female Patients With Myofascial Pain Syndrome Related to Upper Trapezius Active Trigger Points
Condition: Female Patients With Myofascial Pain Syndrome (MPS) Related to Upper Trapezius Active Trigger Points (TP)
MeSH terms: Myofascial Pain Syndromes; Fibromyalgia; Syndrome
Study type: Interventional

Summary: 
      To investigate the effectiveness of muscle inhibition and space correction techniques of
      kinesiotaping (KT) method; on pain, functional status and quality of life in female patients
      with myofascial pain syndrome (MPS) related to upper trapezius active trigger points (TP) in
      comparison to control group and to determine the advantage of each technique over another.
    

Detailed description: 
      The investigators conducted a prospective, randomized, controlled trial involving 93 female
      patients with MPS related to upper trapezius TPs and randomized the patients to KT treatment
      group with space correction technique and home exercise program (KSCT, n=20), KT treatment
      group with muscle inhibition technique and home exercise program (KMIT, n=24) and control
      group (CG, n=27) which received home exercise program only. Patients were evaluated by
      numerical rating scale (NRS) for their average and maximum pain intensity, Turkish version of
      neck disability index (NDI), and short form-36 (SF-36) scales. Statistical tests were
      conducted at the 0.05 significance level for all outcome measures.
    

Intervention name(s): Kinesiotaping with space correction technique; Kinesiotaping with muscle inhibition technique; Home exercise program
Intervention type(s): Other; Other; Other
Intervention description(s): Kinesiotaping with space correction technique twice per week for two weeks along with home exercise program; Kinesiotaping with muscle inhibition technique twice per week for two weeks along with home exercise program; Home exercise program which consists of stretching exercises towards neck area
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Myofascial pain syndrome, kinesiotaping, upper trapezius, home exercise program
Study to Explore Drug-drug Interactions Between DWC20155 and DWC20156 in Healthy Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      A randomized, open-label, oral dose, crossover study to explore drug-drug interactions
      between DWC20155 and DWC20156 in healthy subjects.
    


Intervention name(s): DWC20155; DWC20156
Intervention type(s): Drug; Drug
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Safety, Tolerability and PK of Imeglimin in Japanese Volunteers
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will assess the pharmacokinetics of single and repeated doses of imeglimin in
      healthy Japanese subjects, and the safety and tolerability of single and repeated doses of
      imeglimin in healthy Japanese subjects.
    

Detailed description: 
      Combined single and repeated dose groups with 3 escalating doses
    

Intervention name(s): Imeglimin; Placebo
Intervention type(s): Drug; Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Comparison of Anyu Peibo With Placebo in Treatment of MDD，Ⅱb
Condition: Major Depressive Disorder
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate the safety and efficacy of Anyu Peibo Capsule
      comparing with placebo in the treatment of Chinese Patients with Depression. And to provide
      some scientific evidence for protocol designing in following phase Ⅲ clinical trial.
    


Intervention name(s): Anyu Peibo; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Anyu Peibo Capsule, 0.8g twice per day, oral after breakfast and supper; Placebo Capsule, twice per day, oral after breakfast and supper
Other intervention name(s): Anyu Peibo Capsule
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Transcutaneous Measurement of Jaundice in the Newborn
Condition: Hyperbilirubinemia, Neonatal; Jaundice, Neonatal
MeSH terms: Hyperbilirubinemia, Neonatal; Jaundice, Neonatal; Jaundice; Hyperbilirubinemia
Study type: Observational

Summary: 
      Prospective comparison of measurement of bilirubin in jaundiced newborns by a transcutaneous
      device (bilirubinometer) and laboratory analysis of blood samples.

      We hypothesise that correlation of the two measurements depend on bilirubin level,
      gestational age as well as postnatal age.
    

Detailed description: 
      Whenever a blood sample is drawn for measurement of bilirubin in a newborn, a transcutaneous
      measurement of skin yellow color will be made. Such measurements will also be included in all
      infants when a CRP-test (blood sample for C-reactive protein) has been ordered, as well as in
      connection with the routine blood sampling for metabolic screening. Only infants where
      parents have given written consent for their infant will be included in the study.
    

Intervention name(s): Measurement of bilirubin in blood and skin color
Intervention type(s): Procedure
Intervention description(s): Blood sampling and analysis, measurement of skin color by transcutaneous bilirubinometry
Other intervention name(s): Diagnosis of jaundice
Intervention MeSH terms: Bilirubin
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Newborn infants admitted to normal newborn nursery
      
Keywords: Hyperbilirubinemia; Neonatal; Serum bilirubin; Transcutaneous bilirubin; Skin color
OLGA Stage is More Appropriate in Predicting Early Gastric Cancer
Condition: Early Gastric Cancer
MeSH terms: Stomach Neoplasms
Study type: Observational

Summary: 
      The aim of the present study was to evaluate characteristics of background mucosa in early
      gastric cancer (EGC), and to seek for the optimal assessment for EGC screening.
    

Detailed description: 
      Japanese endoscopic gastric atrophy (EGA) classification, operative link on Gastritis
      Assessment (OLGA), operative link on intestinal metaplasia assessment (OLGIM) and gastritis
      pattern are used in evaluating the severity of gastritis and intestinal metaplasia in
      different countries, which are risk factors of gastric cancer. The aim of the present study
      was to evaluate characteristics of background mucosa in early gastric cancer (EGC), and to
      seek for the optimal assessment for EGC screening.

      A prospective study was conducted encompassing EGC patients (cases) and non-EGC patients
      (controls). All patients were performed endoscopic examination and systematically biopsied.
      Outcome measures were assessed and compared, including EGA classification as well as the
      OLGA/OLGIM assessment. Helicobacter pylori(H. pylori) status was detected in the meantime. A
      stepwise logistic regression model was performed to analyze correlations between EGA, OLGA,
      OLGIM and EGC.
    

Intervention name(s): gastric atrophy and intestinal metaplasia
Intervention type(s): Other
Intervention description(s): use Japanese endoscopic gastric atrophy classification, Operative Link on Gastritis Assessment (OLGA), Operative Link on Gastric Intestinal Metaplasia Assessment (OLGIM) to evaluate the severity of gastric atrophy and intestinal metaplasia
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The study involved consecutive patients from 40-80 years who undergoing
        esophagogastroduodenoscopy
Fentanyl Sublingual Spray for the Treatment of Moderate to Severe Post-Operative Pain
Condition: Pain
MeSH terms: Pain, Postoperative
Study type: Interventional
Phase: Phase 2

Summary: 
      The primary objective of this trial is to evaluate analgesic efficacy of Fentanyl Sublingual
      Spray compared with placebo in participants with postoperative pain after a bunionectomy.
    


Intervention name(s): Fentanyl; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Fentanyl delivered via sublingual spray; Matching placebo delivered via sublingual spray
Intervention MeSH terms: Fentanyl
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Spinal Curvature, Mobility, and Low Back Pain Relationship in Women With and Without Urinary Incontinence
Condition: Urinary Incontinence
MeSH terms: Urinary Incontinence; Enuresis
Study type: Interventional

Summary: 
      The aim of this study was to investigate the relationship among sagittal spinal curvatures,
      mobility, and low back pain in women with and without urinary incontinence.
    


Intervention name(s): Spinal Mouse® measurement; Low back pain intensity measurement; Urogenital symptoms measurement; Disability caused by low back pain
Intervention type(s): Device; Behavioral; Behavioral; Behavioral
Intervention description(s): The sagittal thoracic spinal curvature and mobility of all participants were assessed with Spinal Mouse® (Idiag, Fehraltorf, Switzerland) in standing position.; Low back pain intensity of the patients was questioned by Visual Analogue Scale; The presence and severity of various urogenital symptoms was assessed with the Urogenital Distress Inventory-6; Disability caused by low back pain was assessed with the Oswestry Disability Index
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Diagnostic
A Study in Healthy Men and Women to Test Which Effects Memantine and BI 425809 Have on Each Other
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      Investigate the effect of steady state exposures of memantine on the steady-state
      pharmacokinetics of BI 425809 and vice versa in healthy subjects.
    


Intervention name(s): BI 425809; Memantine
Intervention type(s): Drug; Drug
Intervention description(s): Film coated tablet; Film coated tablet
Intervention MeSH terms: Memantine; BI 425809
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Study to Assess Safety and Tolerability of AZD4547 in Japanese Patient
Condition: Cancer; Advanced Solid Malignancies
MeSH terms: Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary purpose of this study is to explore the safety and tolerability of AZD4547 in
      Japanese patients with advanced solid malignancies.
    

Detailed description: 
      A Phase I, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics
      and Preliminary Anti-tumour Activity of Ascending Doses of AZD4547 in Japanese Patients with
      Advanced Solid Malignancies.
    

Intervention name(s): AZD4547
Intervention type(s): Drug
Intervention description(s): film coated tablet, PO, twice daily
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Phase I; cancer; solid tumours; advanced solid malignancies; dose escalation; FGFR TKI; Japanese
Safety and Performance of a Hernia Blocking System
Condition: Disk Herniated Lumbar
MeSH terms: Hernia
Study type: Interventional

Summary: 
      Prospective, multi-center, single-arm clinical study to assess the performance of an Hernia
      Blocking System in preventing clinically symptomatic recurrent lumbar disc herniation.
    


Intervention name(s): Hernia Blocking System
Intervention type(s): Device
Intervention description(s): Hernia Blocking System device implanted during a lumbar discectomy procedure
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Comparison of Two Exercise Programs on Knee Motor Control
Condition: Knee Pain; Patellofemoral Pain
MeSH terms: Patellofemoral Pain Syndrome
Study type: Interventional
Phase: Phase 2

Summary: 
      Pain at the front of the knee is a common condition treated by physical therapists. Treatment
      may consist of generalised strengthening exercises directed at the quadriceps muscle or
      specific retraining aimed at restoring motor control at the knee. This study compared these
      two exercise programs in a group of people who were painfree at the time to evaluate their
      effect on motor control. It was hypothesised that only the motor retraining program would
      influence motor control at the knee.
    


Intervention name(s): Motor control retraining program; Quadriceps strengthening program
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Specific retraining of VMO activation in a low-load situation,and progressed to integrate more functional positions. Use of dual channel biofeedback was incorporated; 4 exercises focused on quadriceps strengthening commencing at a resistance of 60% 1 repetition maximum. Each exercise was performed for 3 sets of 10 repetitions
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: knee pain; exercise; rehabilitation
Use of Respiratory Therapists (RTs) to Improve Outcomes and Quality of Life in Patients With COPD
Condition: Chronic Obstructive Pulmonary Disease (COPD)
MeSH terms: Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Study type: Observational [Patient Registry]

Summary: 
      Evaluate subjects in an prospective randomized controlled trial in which subjects will be
      administered scientifically validated questionnaires to determine the effect of the education
      and case management by Respiratory Therapists (RTs) on improvements in: health outcomes and
      quality of life as primary endpoints

      Utilize: Chronic Respiratory Disease Questionnaire (CRQ)

      The secondary endpoints will be: Rate of exacerbation's, Health care utilization (emergency
      room encounters, hospital admissions)
    

Detailed description: 
      Evaluate subjects in an prospective randomized controlled trial in which subjects will be
      screened and administered scientifically validated questionnaires at study entry and during
      the observation period at specified intervals to determine the effect of the education and
      case management by Respiratory Therapists (RTs) on improvements in health outcomes and
      quality of life as primary endpoints, utilizing the Chronic Respiratory Disease Questionnaire
      (CRQ). The secondary endpoints will be rate of exacerbation's and health care utilization
      (emergency room encounters, hospital admissions).
    

Intervention name(s): Respiratory Therapist Education and Case Management
Intervention type(s): Other
Intervention description(s): Respiratory Therapists will conduct home care visits over a period of one-year at two-week intervals
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients who are diagnosed with COPD
      
Keywords: COPD; Respiratory Therapist; Case Management; Education