bioihbjkbjnl/mcl2 huggingface dataset:
Traumatic Characteristics of the Forensic Cases Admitted to Emergency Department and Errors in the Forensic Reports
Condition: Emergencies; Trauma
MeSH terms: Emergencies
Study type: Observational

Summary: 
      Objectives: to detect the mistakes and deficiencies of the forensic reports which was written
      and to detect the injury characteristics of the forensic cases applied to emergency service
      of a tertiary hospital.
    

Detailed description: 
      All patients who applied for reasons such as crushing, traffic accidents, firearms and
      explosive injuries, assault, all kinds of injuries, burns, electric shock, asphyxia, torture,
      child abuse, falls and other injuries, poisoning and suicide attempt are a forensic
      case.Traumatic forensic cases are often confronted in emergency departments, Aim to this
      study is to detect the mistakes and deficiencies of the forensic reports which was written
      and also aimed to detect the injury characteristics of the forensic cases applied to
      emergency department which is the most important center in region at a tertiary hospital.
    

Intervention name(s): Forensic cases
Intervention type(s): Other
Intervention description(s): Forensic cases which were admitted to the Emergency Department
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Traumatic forensic cases which applied to Emergency Department of Adıyaman University
        Tranining and Research Hospital, between January 01, 2014 and December 31, 2014.
Measuring Daily Grain Intake Study
Condition: Healthy Volunteers
Study type: Interventional

Summary: 
      The primary objective of this study is to identify markers of daily whole grain oat and whole
      grain wheat intake in humans.
    

Detailed description: 
      The aim of this study is to identify compounds that are found in blood and urine and are
      derived from repeated daily consumption of whole grain oat or whole grain wheat intake so
      that epidemiological studies can be conducted to provide more accurate associations between
      whole grain intake and health.
    

Intervention name(s): Control Refined Grain Diet; Low Whole Grain Oat Diet; High Whole Grain Oat Diet; Low Whole Grain Wheat Diet; High Whole Grain Wheat Diet
Intervention type(s): Other; Other; Other; Other; Other
Intervention description(s): Subjects will be fed the average American diet except it will be free of whole grains; Subjects will be fed the average American diet with addition of a low level of whole grain oats; Subjects will be fed the average American diet with addition of a high level of whole grain oats; Subjects will be fed the average American diet with addition of a low level of whole grain wheat; Subjects will be fed the average American diet with addition of a high level of whole grain wheat
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Other
Pelvic Floor Muscle Training on the Quality of Life in Women With Urinary Incontinence
Condition: Urinary Incontinence; Quality of Life
MeSH terms: Urinary Incontinence; Enuresis
Study type: Interventional

Summary: 
      Aim: To assess the influence of pelvic floor muscles group training in the quality of life
      and functionality of these muscles in women with UI.

      Study design: This is a randomized controlled trial.
    

Detailed description: 
      Search location: Urogynecology Ambulatory Care of Porto Alegre Clinical Hospital (HCPA)

      Patients or participants: Women will be included in aged 35-70 years who have had sexual
      intercourse in the last 12 months and who are able to understand the instruments, besides
      signing an informed consent form. Women will be excluded with latex allergy, who have made
      pelvic radiotherapy, or be undergoing chemotherapy, puerperal a year, or who use
      antidepressants and / or anxiolytics.

      Intervention and measures: The evaluation consists of a medical history form, which will
      include personal data; the assessment of the MAP function is performed by the pressure
      biofeedback; for assessment of quality of life will use the questionnaire ICQI-SF and sexual
      function the PISQ-12 before and after Pelvic Floor Muscle Training.

      Expected results: To estimate effectiveness of Pelvic Floor Muscle Training in the quality of
      life and functionality of these muscles in women with urinary incontinence.
    

Intervention name(s): Experimental; Control
Intervention type(s): Other; Other
Intervention description(s): Profile of participants: an anamnesis file was used to collect personal data;
To evaluate the quality of life: To evaluate the quality of life, using International Consultation on Incontinence Questionnaire (ICIQ-Short form) in women with urinary incontinence in baseline and after 12 weeks of intervention;
To evaluate the pelvic floor muscle functionality: To evaluate the pelvic floor muscle functionality, using PERFECT Scale and Pressure Biofeedback in baseline and after 12 weeks of intervention;; Profile of participants: an anamnesis file was used to collect personal data;
To evaluate the quality of life: To evaluate the quality of life, using International Consultation on Incontinence Questionnaire (ICIQ-Short form) in women with urinary incontinence in baseline and after 12 weeks of intervention;
To evaluate the pelvic floor muscle functionality: To evaluate the pelvic floor muscle functionality, using PERFECT Scale and Pressure Biofeedback in baseline and after 12 weeks of intervention;
Other intervention name(s): Pelvic Floor Muscle Training in group; Pelvic Floor at Home
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Women; Pelvic Floor Muscles
Study to Identify Biomarkers for Protein Intake
Condition: Identify New Biomarkers in Blood or Urine After Consumption of Meat Protein, Dairy Protein and Grain Protein in Healthy Subjects.
Study type: Interventional

Summary: 
      Results from observational studies suggest a small beneficial association between protein and
      blood pressure that may be mainly attributable to the intake of protein from plant sources.
      In epidemiological studies biomarkers of dietary intake are useful to estimate intake more
      reliably. Dietary studies using biomarkers of protein intake generally show stronger
      associations with health outcomes. However, data on biomarkers for specific types of protein
      (e.g. from dairy, meat, grain and legumes) are scarce. Therefore the purpose of this study is
      to identify new biomarkers for the intake of protein from meat, dairy and grain. In addition
      the secondary purpose is to investigate whether intake of protein from these sources
      influences kidney filtration rate and urinary acid excretion differentially.
    


Intervention name(s): Run in diet; High meat protein diet; High dairy protein diet; High grain protein diet
Intervention type(s): Other; Other; Other; Other
Intervention description(s): Fully controlled dietary period during 9 days. Participants will receive approximately 15 en% of protein. The amount of protein intake from dairy, meat, and grain will be equal to each other; Fully controlled diet during 7 days. Participants will consume 18 en% protein, mainly from meat.; Fully controlled dietary intervention during 7 days. Participants will consume 20 en% protein. Mainly from dairy; Fully controlled dietary intervention for 7 days. Participants will consume 20 en% of protein. Mainly from grain
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: Dietary protein; Biomarkers; filtration rate; urinary acid excretion
Empirical Rescue Therapies of Helicobacter Pylori Infection
Condition: Functional Dyspepsia; Scarred Peptic Ulcer
MeSH terms: Peptic Ulcer; Dyspepsia
Study type: Interventional
Phase: Phase 4

Summary: 
      The increase of antibiotic resistance to H. pylori causes failure of treatment. Furazolidone,
      amoxicillin and tetracycline are good candidates for rescue therapy since resistance to these
      three antimicrobials was rare. It is necessary to assess the efficacy and safety of these
      four bismuth-containing quadruple regimens with above antibiotics as empirical rescue
      therapies for H. pylori eradication.
    


Intervention name(s): Proton Pump Inhibitor; Bismuth; Metronidazole; Tetracycline; Furazolidone; Amoxicillin
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Other intervention name(s): Lansoprazole; Bismuth potassium citrate
Intervention MeSH terms: Amoxicillin; Metronidazole; Tetracycline; Furazolidone; Potassium Citrate; Lansoprazole; Bismuth; Proton Pump Inhibitors
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Study on Hypoallergenic Hair Dye
Condition: Contact Dermatitis; Allergy; Dermatitis; Dermatitis
MeSH terms: Dermatitis, Atopic; Dermatitis; Dermatitis, Contact
Study type: Observational

Summary: 
      Permanent hair dyes are commonly used in over the counter direct to consumer products and
      within hair salons. Allergy, also known as contact dermatitis, to hair dye is a well known
      phenomenon. Herein, we seek to decrease the risks of allergy to hair dyes by testing a novel
      version of p-phenylenediamine (PPD) with less allergy potential.
    

Detailed description: 
      For patients with PPD sensitizations, it is important to find alternatives for dark hair
      dyes. P-toluenediamine (PTD) and potentially also 2-methoxyethyl p-phenylenediamine (ME-PPD)
      show cross-reactivity with PPD and therefore we want to prove that our new compounds PPD-6
      and PPD-7 show no or significantly reduced cross-reactions with PPD and do not induce
      relevant allergic reactions in patients with proven PPD sensitizations.

      Our specific aims for this study are the following:

      A1) To show that PPD 6 and PPD 7 have reduced or optimally no reaction in standard patch
      tests in patients with proven allergy to PPD A2) To compare the sensitization pattern to
      other possible commercially available alternatives for hair dye, such as ME-PPD and PTD A3)
      To evaluate and rule out any possible non-specific irritant reaction of PPD-6 and PPD-7 in
      these patch tests (i.e. confirm in-vitro safety profile in-vivo)
    

Intervention name(s): Sensitivity Patch Testing
Intervention type(s): Diagnostic Test
Intervention description(s): Testing patches will be applied on the upper arms. Para-phenylene diamine (PPD) 1% will be applied on one upper arm. Para-toluenediamine sulfate (PTD), 2-methoxyethyl p-phenylenediamine (ME-PPD), PPD6 and PPD7 will be applied to the other upper arm.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Adults with sensitivity to PPD and/or PTD
Sleep Quality After Stellate-ganglion Block of Patients Undergoing Breast Cancer Operation
Condition: Sleep Deprivation
MeSH terms: Ganglion Cysts; Sleep Deprivation
Study type: Interventional
Phase: Phase 4

Summary: 
      Stellate-ganglion block have been done safely for more than 60 years. It has proved to
      provide survivors of breast cancer with relief from hot flushes and sleep dysfunction with
      few or no side-effects. The aim of the present study is to evaluate postoperative sleep
      quality of patients undergoing breast cancer surgery with Stellate-ganglion block performed
      in the operation.
    

Detailed description: 
      This study is a prospective, randomized, controlled (randomized, parallel group, concealed
      allocation), double-blinded trial. All patients undergoing breast cancer operation will be
      randomized 1:1 to the treatment intervention with general anesthesia as an adjunct to
      Stellate-ganglion block with 0.25% ropivacaine hydrochloride or saline. The objective of the
      trial is to evaluate the postoperative sleep quality of patients undergoing breast cancer
      operation with Stellate-ganglion block 0.25% ropivacaine hydrochloride or saline.
    

Intervention name(s): 0.25% ropivacaine hydrochloride; saline
Intervention type(s): Drug; Drug
Intervention description(s): stellate-ganglion block with 0.25% ropivacaine hydrochloride; stellate-ganglion block with saline
Intervention MeSH terms: Ropivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: bispectral index; regional cerebral oxygen saturation; Stellate-ganglion block
Descriptive Study of Biological Stress and Perceived Stress at the Center 15
Condition: Physiological Stress; Psychological Stress
MeSH terms: Stress, Psychological
Study type: Interventional

Summary: 
      The purpose of this study is to describe biological stress (cortisolemia) and perceived
      stress in Emergency Call Center Operators and Doctors while processing a center 15 call.
    

Detailed description: 
      Sample description : qualitative variables be expressed as percentages, numbers and 95%
      confidence intervals Quantitative variables will be expressed as means, standard deviations
      or medians, range, interquartile intervals Description of biological stress : it will be
      described by calculating the difference between the observed peek or peeks of cortisol ans
      the cortisol level measured at rest (means, standard deviations or medians, range,
      interquartile intervals) Description of perceived stress : the AVS will be described in terms
      of means and standard deviation Comparison of the peek-delta/base level of cortisol in the 3
      different workstations of the call center operators according to the non parametrical
      Kruskall Wallis test. Same for the lengthof service of the call operator, the severity of the
      call and the status of the doctor The AVS score (perceived stress) will be compared to the
      peek-delta/base level of cortisol (biological stress) thanks to the Spearmann correlation
      coefficient.
    

Intervention name(s): salivary sampling by a biomnis swab
Intervention type(s): Other
Intervention description(s): Each call operator will have a series of salivary sampling taken when assigned to call reception, to the unit deployment station and to the assessment station.
Only one sampling will occur to doctors who are assigned to a single workstation.
Sampling will be taken every 15 minutes during one hour and half and one last sample will be taken 2 hours after the call.
To improve interpretation of the results, a series of control-samples will be taken among the call operators and doctors during a day off and not during a security break.
There will be 4x8 samples taken for each call operator and 2x8 samples per doctor.
They will also be frozen at a temperature of -4°C and sent to the laboratory of the CHR Metz Thionville.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: stress; cortisol; emergency call center; hospital staff
A Proof of Concept Study of Inhaled Nitric Oxide for Adults With Pulmonary Non-Tuberculous Mycobacterial Infection
Condition: Nontuberculous Mycobacterium Infection
MeSH terms: Infections; Communicable Diseases; Mycobacterium Infections; Mycobacterium Infections, Nontuberculous
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate the efficacy and safety of open-label exposure of
      gNO in patients with NTM lung disease. Subjects will receive the study drug by inhaling
      through a nasal mask. Subjects will be treated for 3 weeks (5 days per week) and followed
      monthly for 3 months.
    


Intervention name(s): gNO
Intervention type(s): Drug
Intervention description(s): This is a proof-of-concept study in which all subjects will be treated with gNO (i.e. no control) to see if there can be a microbiological effect by conversion to negative sputum cultures and how long that effect can be sustained following treatment.
Participants will be treated for 3 weeks (5 days per week), Monday through Friday, and followed monthly for 3 months.
The treatment period includes a physical exam, vital signs, blood tests, echocardiogram, spirometry test, sputum sample, questionnaires, and the inhalation gas treatment. During the inhalation gas treatment, participants will wear a face mask (similar to an oxygen mask) and will be given nitric oxide gas through the participants nose for three treatments with fifty minutes each time. They will then be followed up monthly during the Follow-up period with tests that include a physical exam and questionnaires.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
ACL Repair and Multimodal Analgesia
Condition: Pain
Study type: Interventional
Phase: Phase 4

Summary: 
      This study will evaluate the effectiveness of an aggressive multimodal regimen versus
      standard multimodal for Anterior Cruciate Ligament (ACL) repair using hamstring graft for
      patients having surgery in our outpatient surgicenter.
    


Intervention name(s): multimodal:acetaminophen, gabapentin, ketamine, bupivacaine; placebo pills and injectables
Intervention type(s): Drug; Drug
Intervention description(s): acetaminophen, gabapentin, ketamine, bupivacaine and standard care which includes ketorolac, bupivacaine, fentanyl, ondansetron, dexamethasone, sevoflurane; receives standard care which includes ketorolac, bupivacaine, fentanyl, ondansetron, dexamethasone, sevoflurane plus placebos of intervention arm meds
Intervention MeSH terms: Acetaminophen; Ketamine; Gabapentin; Bupivacaine
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Endometrial Effects of Daily Progesterone s.c. 25 and 50 Mg Aqueous Formulation to Female Healthy Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a multiple dose, observer blind, randomised, parallel groups pharmacodynamic and
      pharmacokinetic study to assess the endometrial effects (predecidual changes) of a new
      aqueous progesterone formulation administered s.c. at the dose of 25 and 50 mg/day.
    

Detailed description: 
      This study is designed in order to assess the efficacy of the investigational product
      (Progesterone acqueous s.c. formulation) when it is administered at the dose of 25 and 50 mg.
      The induced predecidual changes will be evaluated through endometrial bioptic samplings,
      performed on day 11 and will be compared between the two treatment groups.

      The pharmacokinetic evaluation was designed according to internationally recognised
      guidelines for PK studies.
    

Intervention name(s): Progesterone
Intervention type(s): Drug
Intervention MeSH terms: Progesterone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single
Primary purpose: Treatment
Keywords: pharmacodynamic and pharmacokinetic study; Progesterone; healthy volunteers; Endometrial decidualisation
The CAPTURE Study: Validating a Unique COPD Case Finding Tool in Primary Care (Aim 1)
Condition: Chronic Obstructive Pulmonary Disease (COPD)
MeSH terms: Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Study type: Observational

Summary: 
      A prospective multi-center study to define the sensitivity and specificity of CAPTURE for
      identifying previously undiagnosed patients with clinically significant COPD in a broad range
      of primary care settings.
    

Detailed description: 
      The CAPTURE tool consists of a 5-item self-administered questionnaire and selected use of
      peak expiratory flow (PEF) measurement, designed to identify clinically significant COPD.

      For Aim 1 approximately 5,000 patients will be recruited across 100 participating primary
      care clinics. Eligible participants will undergo a baseline visit during which the CAPTURE
      tool and PEF will be obtained, as well as spirometry and other participant characteristics.
    

Intervention name(s): CAPTURE Tool
Intervention type(s): Other
Intervention description(s): CAPTURE Tool: a self administered 5-item questionnaire with peak expiratory flow measurements
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Adult men and women recruited from a broad range of primary care settings across the United
        States.
      
Keywords: CAPTURE, COPD
Effects of Administration of Fostamatinib on Blood Concentrations of Pioglitazone in Healthy Subjects
Condition: Rheumatoid Arthritis; Healthy Volunteers; Pharmacokinetics; Pioglitazone; Drug-drug Interaction; Amount of Pioglitazone in Blood
MeSH terms: Arthritis; Arthritis, Rheumatoid
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to investigate the drug interaction between fostamatinib and
      pioglitazone by comparing the safety, tolerability and plasma concentration of pioglitazone
      when administered alone and with fostamatinib in healthy subjects.
    


Intervention name(s): fostamatinib; pioglitazone
Intervention type(s): Drug; Drug
Intervention description(s): oral tablets, 100mg (2 X 50mg) twice daily for 8 days; oral tablets, 30mg single dose per period
Intervention MeSH terms: Pioglitazone
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Phase 1; healthy volunteers; pharmacokinetics; Rheumatoid arthritis; RA; fostamatinib; pioglitazone; drug-drug interaction
Oral Metronidazole With Lactobacillus Vaginal Suppositories to Prevent Recurrence of Bacterial Vaginosis
Condition: Bacterial Vaginosis; Recurrence
MeSH terms: Vaginosis, Bacterial; Vaginal Diseases; Recurrence
Study type: Interventional
Phase: Phase 4

Summary: 
      We are trying to determine if Oral Metronidazole with Lactobacillus Vaginal Suppositories is
      better than Oral Metronidazole in Preventing the Recurrence of Bacterial Vaginosis
    

Detailed description: 
      Bacterial vaginosis (BV) is the most prevalent cause of symptomatic vaginal discharge in the
      U.S. and has been associated with complications including preterm delivery of infants, pelvic
      inflammatory disease (PID), urinary tract infections (UTI) and acquisition/transmission of
      sexually transmitted diseases (STDs) including human immunodeficiency virus (HIV).

      Control of BV has been advocated as a means of decreasing the prevalence of these
      complications. However, the etiology of BV remains unknown and the current treatment regimens
      are inadequate in terms of initial cure and recurrence rates.

      Based on currently national guidelines by using oral metronidazole 400 BID for 7 days, a high
      recurrence rate of BV were reported.

      We hypothesize that the Oral Metronidazole with Lactobacillus Vaginal Suppositories is better
      than Oral Metronidazole in Preventing the Recurrence of Bacterial Vaginosis
    

Intervention name(s): Metronidazole Oral; "Metronidazole" and "Lactobacillus"
Intervention type(s): Drug; Drug
Intervention description(s): Oral metronidazole 400 mg BID for 7 days at first month.; Oral metronidazole metronidazole 400 mg BID for 7 days at first month and Lactobacillus vaginal suppositories for 10 days at first month,second month and third month.
Intervention MeSH terms: Metronidazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Recurrence; Lactobacillus Vaginal Suppositories