Pregnancy-related Changes in Melanocytic Nevi
Condition: Melanocytic Nevi (MN)
MeSH terms: Nevus; Nevus, Pigmented; Nevus, Epithelioid and Spindle Cell
Study type: Observational

Summary: 
      This study is

        -  to analyze whether more changes in melanocytic nevi (MN) occur in women during and after
           pregnancy compared to non-pregnant women of the same age

        -  and to analyze psychological effects of total body mapping and dermoscopic examination
           assisted by artificial intelligence during pregnancy.
    

Detailed description: 
      Melanocytic nevi (MN) are believed to undergo macroscopic and dermoscopic alterations during
      pregnancy. Possible changing features previously observed include color, pigment network,
      size, vascularization and the emerging of dots and globules. Recent studies have reported of
      melanoma being associated with increased mortality in pregnant women when compared to
      non-pregnant women. The new FotoFinder® ATBM master device provides the combination of total
      body mapping with deep learning-driven body scan algorithm which identifies all pigmented
      skin lesions of the body surface by pattern recognition software and supplies a risk
      assessment score (0.0-1.0; 0 indicating no suspicion for melanoma, 1 indicating a high
      suspicion for melanoma).

      This study is

        -  to analyze whether more changes in melanocytic nevi (MN) occur in women during and after
           pregnancy compared to non-pregnant women of the same age

        -  and to analyze psychological effects of total body mapping and dermoscopic examination
           assisted by artificial intelligence during pregnancy.
    

Intervention name(s): standard-of-care clinical skin examination; skin assessment with the 2D FotoFinder ATBM master system; data collection by participant questionnaire
Intervention type(s): Other; Diagnostic Test; Other
Intervention description(s): inspection of melanocytic nevi by dermatologist; The FotoFinder® ATBM master device provides the combination of total body mapping with deep learning-driven body scan algorithm which identifies all pigmented skin lesions of the body surface by pattern recognition software and supplies a risk assessment score (0.0-1.0; 0 indicating no suspicion for melanoma, 1 indicating a high suspicion for melanoma).The integrated software analyzer scores regarding malignancy probability of the moles (FotoFinder® score: 0.0-1.0) will be collected.; At baseline, the participants will complete a questionnaire concerning their previous exposure to sun, their current sun-related protective behaviours, their history of skin check frequency and skin cancer at baseline. Additionally, in each consultation newly-created study-specific questions concerning the participants' examination experience, the sun-related protective behaviours and worries about skin cancer throughout the study will be investigated.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Pregnant volunteers recruited through the Department of Gynaecology and Obstetrics at the
        University Hospital of Basel and through study advertisement displayed at gynaecological
        practices in the city of Basel.

        Non-pregnant volunteers recruited through study advertisement displayed at the University
        of Basel and at the Department of Dermatology at the University Hospital Basel and through
        an advertisement.
      
Keywords: skin cancer screening; total body mapping; deep learning-driven body scan; FotoFinder® ATBM master; malignant melanoma; pregnancy-related changes in melanocytic nevi