bioihbjkbjnl/mcl2 huggingface dataset:
The Effects of Training and Relaxation on Fibromyalgia.
Condition: Fibromyalgia
MeSH terms: Fibromyalgia; Myofascial Pain Syndromes
Study type: Interventional

Summary: 
      Effects of physical training and relaxation exercise on pathophysiological mechanisms and
      symptoms in finbromyalgia patients.
    

Detailed description: 
      A multi-center trial examining the effects of progressive resistance group exercise compared
      with an active control group (relaxation). A person-centred model of exercise was used. The
      intervention was performed twice a week for 15 weeks and was supervised by experienced
      physiotherapists.

      Secondary aims off this multi-center study was to improve the understanding of pain
      mechanisms in fibromyalgia and how these are affected by physical exercise. Please see
      references of published articles for details.
    

Intervention name(s): Physcial activity
Intervention type(s): Behavioral
Intervention description(s): Strenght training Relaxation exercise
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Strength exercise; Physical exercise; Physiotheraphy
The Use of the Social Networking to Promote Educational and Consultative Actions Among Kidney Transplanted Adolescents.
Condition: Kidney Transplantation; Education
Study type: Interventional

Summary: 
      This study is designed to compare the knowledge, satisfaction and self-esteem of kidney
      transplanted adolescents measured through questionnaires between two groups: patients
      undergoing conventional treatment with no other intervention versus patients undergoing
      conventional treatment and receiving additional educational and consultative actions using a
      closed facebook group.
    

Detailed description: 
      Based on literature, there are strong evidences that the use of social media improves the
      outcomes of chronic treatments. Currently, there is no study using social media as an
      education tool in kidney transplant patients in Brazil. This study is designed to answer the
      question: "Does the use of a popular social media such as facebook improves the knowledge,
      satisfaction and self-steem levels among kidney transplant adolescents when compared with
      their peers ?" This is a non-blinded randomized clinical trial. Patients will be randomly
      included into one of the two groups: the control group who will not receive any intervention
      or the facebook group (who will receive additional educational and consultative support
      through a closed facebook group) After three months, knowledge level, satisfaction level and
      self-esteem will be assessed by specific designed questionnaires and by the application of
      the Rosenberg's self-esteem scale. The study will have a sample of 122 subjects, equally
      divided (61 participants in each group). Collected data will be compared using the chi square
      test.
    

Intervention name(s): Facebook group
Intervention type(s): Behavioral
Intervention description(s): A closed facebook group used to deliver multimedia content specifically produced to inform the participants about chronic kidney disease, kidney transplantation and related topics. This group is also used to share doubts and life experiences among participants and the interdisciplinary team.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants are assigned to participate into one of two groups (control group or intervention group) in parallel for the duration of the study. The control group receives no form of intervention or education. The intervention group participates into a closed facebook group.
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Kidney transplantation; Facebook; Education; Adolescent; Social Networking
Social Motivation Intervention for Children With Autism Spectrum Disorder: Improving Peer Initiation
Condition: Autism Spectrum Disorder
MeSH terms: Autistic Disorder; Autism Spectrum Disorder; Child Development Disorders, Pervasive
Study type: Interventional

Summary: 
      The purpose of this study is to investigate whether a social initiation motivation
      intervention (SIMI) focused on training children with ASD to initiate to peers during
      structured play activities will result in more frequent initiations to typically developing
      peers during free play. The SIMI approach under investigation uses behavioral strategies
      based in Applied Behavior Analysis and Pivotal Response Treatment to motivate children with
      ASD to initiate to peers. Children with ASD will be randomly assigned to either the SIMI or a
      waiting list. Treatment will be provided for 8 weeks in the context of a weekly social skills
      group.
    


Intervention name(s): Social Initiation Motivation Intervention
Intervention type(s): Behavioral
Intervention description(s): The SIMI approach under investigation uses behavioral strategies based in Applied Behavior Analysis and Pivotal Response Treatment to motivate children with ASD to initiate to peers. The adult arranges the play environment in order to promote cooperation and facilitates frequent prompting and reinforcement from peers, thereby enhancing the reward value of peer interactions.
Other intervention name(s): Pivotal Response Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Pivotal Response Treatment; Applied Behavior Analysis; Peer Initiation; Social Skills Group
Safety and Tolerability of E5555 and Its Effects on Markers of Intravascular Inflammation in Subjects With Acute Coronary Syndrome
Condition: Acute Coronary Syndrome
MeSH terms: Acute Coronary Syndrome; Syndrome
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a multi-center, randomized, double-blind, placebo-controlled study to determine the
      safety and tolerability of E5555 in subjects with Acute coronary syndrome (ACS).
    


Intervention name(s): E5555; Placebo
Intervention type(s): Drug; Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Acute Coronary Syndrome
Stabilometry and Plantar Pressures Changes After Progressive Pressure Release in Flexor Digitoum Brevis in Latent Trigger Points
Condition: Bilateral Latent Myofascial Trigger Points of Flexor Digitorum Brevis
Study type: Interventional

Summary: 
      The aim of this clinical trial is to check the effects of progressive pressure release in the
      Flexor digitorum Brevis
    

Detailed description: 
      Eighteen subjects with bilatereal lantent myofascial trigger points wil be recruited for a
      pre- test post-test study. Participants will be from 18 to 40 years old, not obese.
      Participants will be measured before and after bilateral dry needling in Flexor digitorum
      Brevis. The investigators will measure stabilometry variables and static footprint. The
      footprint variables will be divided in bilateral rear foot, bilateral midfoot, bilateral fore
      foot.

      Stabilometry will be measured by displacement of the center of pressures in X and Y with eyes
      open and closed , center of pressure (COP) with eyes open and closed, COP area with eyes open
      and closed, COP antero-posterior (a-p) and medio-lateral (m-lat) directions with eyes open
      and closed, and COP speed. Two trials will be recorded for each condition and the order of
      the conditions will be randomized across subjects, eyes open and eyes closed. Foot plantar
      pressure and surface area of two static footprints will be measured during bipedal standing.
      Static plantar pressure will be evaluated by means of maximum pressure, medium pressure and
      surface area of each aspect of the foot (rearfoot, midfoot, and fore foot).
    

Intervention name(s): progressive pressure release
Intervention type(s): Procedure
Intervention description(s): Bilateral progressive pressure release in latent trigger points of the Flexor digitorum Brevis Muscle
Intervention model: Single Group Assignment
Intervention model description: Pretest posttest of bilateral Flexor digitorum Brevis progressive pressure release intervention
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Foot; Stabilometry; Platform; therapeutics; trigger point
Effect of Cimetidine on the Single-Dose PK of IV- Administered MNTX
Condition: Healthy Adult Subjects
Study type: Interventional
Phase: Phase 1

Summary: 
      This open-label study assesses the single-dose pharmacokinetics of intravenously-administered
      MNTX in healthy adult male and female subjects in the absence of, and in the presence of,
      orally-administered cimetidine.
    


Intervention name(s): methylnaltrexone
Intervention type(s): Drug
Intervention MeSH terms: Methylnaltrexone
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Prospective Randomized Trial of Fruits or Nuts Eaten Between Regular Meals in Healthy Subjects
Condition: Healthy Subjects
Study type: Interventional

Summary: 
      Recruitment of 28 subjects that will be randomized to consume fruit or nuts as snacks between
      regular meals for two months. Laboratory tests for cardiovascular risk factors, metabolic
      rate, liver steatosis and physical activity are investigated ahead of start of the study and
      at the end of the trial period och two months. Participants will be allowed to buy fruits or
      nuts on their own but to keep track (diaries) of the amount consumed. They will be reimbursed
      for the costs of the snacks.
    


Intervention name(s): Fruits; Nuts
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Randomization to extra fruit or nuts as snacks
Other intervention name(s): Randomization to extra fruit or nuts as snacks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: fruit, nuts, liver fat, insulin, glucose; Focus of the study is to compare the often given advice to eat fruit, containing large amount of glucose and fructose, with nuts that are more rich in fat.
Magnesium Sulfate in Obese Preeclamptics
Condition: Preeclampsia
MeSH terms: Pre-Eclampsia
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to learn how medications participant will receive in the course
      of their delivery are metabolized (broken down by the body). The investigators hope to learn
      more about the way drugs are metabolized by pregnant women, and how those drugs are
      distributed in the blood and body compartments and cleared in the urine, and how maternal
      body weight affects the metabolism. With this information the investigators will be able to
      develop a treatment regimen considering factors in the body that affect magnesium levels so
      that the investigators can improve treatment of pregnant women. The goal of the study is to
      understand how different dosing of magnesium sulfate affects blood levels of the magnesium in
      larger women.
    

Detailed description: 
      The purpose of this study is to learn how medications participant will receive in the course
      of their delivery are metabolized (broken down by the body). The investigators hope to learn
      more about the way drugs are metabolized by pregnant women, and how those drugs are
      distributed in the blood and body compartments and cleared in the urine, and how maternal
      body weight affects the metabolism. With this information the investigators will be able to
      develop a treatment regimen considering factors in the body that affect magnesium levels so
      that the investigators can improve treatment of pregnant women. The goal of the study is to
      understand how different dosing of magnesium sulfate affects blood levels of the magnesium in
      larger women.

      Magnesium sulfate is generally given to patients to protect the mother against seizures in
      the case of preeclampsia. Different hospitals in the United States use different doses of
      magnesium sulfate. Participants will receive one of two accepted doses of magnesium sulfate
      for preeclampsia. The dose is usually 4g - 6g at the start, with another dose of 2-3 g every
      hour until 24 hours after delivery. Participants will be assigned to either a dose of 4 g at
      the start, followed by 1g every hour; or a dose of 6 g at the start, followed by 2g every
      hour until treatment for preeclampsia is complete. Participants will receive magnesium
      sulfate in the course of their normal clinical care whether or not they participate in this
      study.
    

Intervention name(s): Magnesium sulfate 4g loading dose, 1g/hr infusion; Magnesium sulfate 6g loading dose, 2g/hr infusion
Intervention type(s): Drug; Drug
Intervention MeSH terms: Magnesium Sulfate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy -- Use in Acute Cholecystitis Sub-Study
Condition: Acute Cholecystitis; Acute Cholangitis
MeSH terms: Cholangitis; Cholecystitis; Acalculous Cholecystitis; Cholecystitis, Acute
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate an imaging system using Indocyanine Green (ICG) to
      assist in real-time identification of anatomy during cholecystectomy (gallbladder removal) in
      patients with acute cholecystitis and cholangitis. We propose to define the effectiveness of
      NIRF-C in identifying the cystic duct junction during cholecystectomy.
    


Intervention name(s): Indocyanine Green (ICG); Near Infrared Fluorescence Cholangiography (NIRF-C)
Intervention type(s): Drug; Device
Intervention description(s): 60-30 minutes prior to cholecystectomy, 2.5 mg of indocyanine green (ICG) will be injected intravenously. An additional 2.5 mg of ICG may be injected intraoperatively if the fluorescence fades prior to imaging.; Near infrared fluorescence cholangiography will be performed intraoperatively in order to image anatomy.
Other intervention name(s): Stryker 1488 Camera System; Stryker L9000 Light Source; Stryker 1488 Coupler; Stryker 10mm Ideal Eyes Laparoscope (0 and 30 degree)
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: acute cholecystitis; acute cholangitis; cholecystectomy
Increased Salt Intake in Healthy Men
Condition: Healthy
Study type: Interventional

Summary: 
      To study the effects of an increased salt intake on metabolic, cardiovascular and
      immunoregulatory functions in healthy men.
    


Intervention name(s): Slow sodium tablets
Intervention type(s): Dietary Supplement
Intervention description(s): 6 g sodium chloride per day over 14 days
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Energy metabolism; Glucose tolerance; Blood pressure; Immunoregulation
Sutent Following Chemotherapy, Radiation and Surgery For Resectable Esophageal Cancer
Condition: Esophageal Cancer
MeSH terms: Esophageal Neoplasms
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to see whether or not the combination of cisplatin, irinotecan
      and radiation, followed by surgery, followed by oral Sutent, is effective and safe for
      patients with resectable esophageal cancer.
    

Detailed description: 
      Survival outcomes for resectable esophageal cancer remain poor. Current data strongly support
      an adjuvant systemic strategy to improve time to progression and survival in this patient
      population. Adding a well-tolerated oral targeted therapy such as Sutent, after a combined
      chemo/radiation/surgery approach in this patient population has the potential to impact on
      the minimal residual disease left behind by relatively effective pre-operative chemoradiation
      and surgery. This has the potential to improve survival. The primary endpoint is to determine
      the feasibility and efficacy of adjuvant Sutent therapy (SU11248) after concurrent
      neoadjuvant therapy with irinotecan, cisplatin, external beam conformal radiotherapy plus
      surgery for potential resectable esophageal cancer. Preclinical and clinical data suggest
      that Sutent will have activity in esophageal cancer, as the results of Sutent activity in
      solid tumors appear to be superior to the results of other antiangiogenic compounds in
      development for esophageal cancer. Therefore, by extrapolation from promising phase I, II and
      III Sutent trials we propose to translate the target effects achieved with Sutent to reduce
      local and systemic therapy failure, and thus metastasis in esophageal cancer.
    

Intervention name(s): Irinotecan; Cisplatin; Radiation; Surgery; sunitinib (Sutent)
Intervention type(s): Drug; Drug; Procedure; Procedure; Drug
Intervention description(s): Irinotecan (50mg/m2)once weekly in weeks 1, 2, 4, 5, 7, and 8; Cisplatin (65mg/m2)once weekly in weeks 1, 2, 4, 5, 7, and 8; Radiation 50 Gy (weeks 4-9); Esophagectomy; sunitinib (Sutent), dose range of 12.5mg - 50mg OD x 1 year post op.
Intervention MeSH terms: Irinotecan; Sunitinib
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: esophageal; esophagus; cancer; sutent; sunitinib
Sonographic Assessment and Visualization of Ectopics in Emergency Medicine
Condition: Ectopic Pregnancy
MeSH terms: Pregnancy, Ectopic; Cardiac Complexes, Premature; Emergencies
Study type: Observational

Summary: 
      Observational study of the use of ultrasound by emergency physicians in the evaluation of
      patients at risk of ectopic pregnancy.
    

Detailed description: 
      Emergency Physicians who have undergone training according to the American College of
      Emergency Physicians Guidelines will be evaluated in the accuracy of performing pelvic
      ultrasounds among patients at risk for ectopic pregnancy.
    

Intervention name(s): Pelvic Ultrasound
Intervention type(s): Device
Intervention description(s): Pelvic ultrasound performed by the emergency physician
Other intervention name(s): Pelvic Sonogram
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        women at risk of ectopic pregnancy in emergency department
      
Biospecimen description: 
      Blood
    
Keywords: bedside ultrasound
Comparison Colon Capsule Endoscopy vs Optical Colonoscopy for Colorectal Cancer Screening in Familiar-Risk Population
Condition: Colorectal Cancer, Genetics of
MeSH terms: Colorectal Neoplasms
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to determine if the adherence to screening in first grade
      relatives of patients with CCR is higher than optical colonoscopy.
    

Detailed description: 
      The purpose of this study is to compare the adherence and effectiveness of colon capsule
      endoscopy (CCE-2) versus conventional colonoscopy to screen first-degree relatives of
      patients with colorectal cancer.
    

Intervention name(s): COLON CAPSULE ENDOSCOPY ADHERENCE; OPTICAL COLONOSCOPY ADHERENCE
Intervention type(s): Procedure; Procedure
Intervention description(s): An exploration with a COLON CAPSULE ENDOSCOPY eaten which capsule has a video-camera in both end to see the colon.; An exploration with an OPTICAL COLONOSCOPY from the anus to see the colon.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Mindfulness and RelaxationTraining for Insomnia (MRTI) on Postmenopausal Women: a Randomized Clinical Trial.
Condition: Primary Insomnia
MeSH terms: Sleep Initiation and Maintenance Disorders
Study type: Interventional

Summary: 
      Summary

      Introduction: Insomnia is a symptom of sleep disorders most prevalent. Primary insomnia, the
      investigators analyzed, often related to stress states acquired, generalized anxiety and
      stress, which are important factors that disrupt normal sleep. The investigators point out a
      fact that still intrigue the students of medicine and sleep that is distorted perception of
      sleep by the sleepless nights, polysomnography shows greater effectiveness than that
      perceived by them. On the other hand, there is evidence that mindfulness techniques may
      reduce symptoms of stress and anxiety as well as improve the general attention, which may
      contribute to a better perception of the effectiveness of sleep. In addition, there are
      studies showing that meditation is associated with metabolic and neurophysiological
      characteristics similar to normal sleep. Objectives: To compare sleepless menopausal women
      trained for 8 weeks in the technique of mindfulness insomniac postmenopausal untrained and
      also assess the quality of sleep experienced meditators menopausal comparing them to the
      group of healthy postmenopausal women untrained in the art.
    

Detailed description: 
      Groups will be assessed by actigraphy, polysomnography and questionnaires for assessing
      stress, depression, anxiety, quality of life, self-pity, subjective states such as sedation
      and other physical or mental attitudes, vitality, emotional state and attentiveness.
      Moreover, prospective memory participants will be evaluated by means of a task as close as
      possible to real life conditions of the volunteers (green) and also the working memory is
      assessed by a test called specific counting span. Menopausal women will be evaluated for the
      presence or absence of bruxism compared to ordinary meditators, all postmenopausal.
    

Intervention name(s): mindfulness training
Intervention type(s): Behavioral
Intervention description(s): mindfulness interventions for 8 weeks for a group of menopausal insomniacs
Other intervention name(s): mindfulness,; meditation,; sleep pattern in meditators women in menopause
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: insomnia,menopause, polysomnography, mindfulness