bioihbjkbjnl/mcl2 huggingface dataset:
Injection of Subcutaneous Glucose 10% in Small Shots is Effective in the Treatment of Diabetic Neuropathic Pain
Condition: Painful Diabetic Neuropathy
MeSH terms: Neuralgia; Diabetic Neuropathies
Study type: Observational

Summary: 
      Observational cohort prospective study with the following of 100 patients of type 1 and type
      2 diabetes mellitus in 2 groups each group 50 patients, each group 30 males, and 20
      females,35 patients with type 2 diabetes and 15 patients type 1 diabetes all have diabetic
      peripheral neuropathy, the second group is considered as control.
    

Detailed description: 
      Observational cohort prospective study with the following of 100 patients of type 1 and type
      2 diabetes mellitus in 2 groups each group 50 patients, each group 30 males, and 20
      females,35 patients with type 2 diabetes and 15 patients type 1 diabetes all have diabetic
      peripheral neuropathy, the second group is considered as control. the ages of all patients
      are between 20 and 50 years.

      The first group was on subcutaneous glucose 0.5 ml per site around subcutaneous nerves in the
      foot region both on palm and sole.which is repeated every 2 weeks for 2 months.

      Pain severity was evaluated by using the Visual Analogue Scale (VAS) which is a numerical
      rating scales, with a straight horizontal line of 100 mm. which is directed from the left
      with severe pain to the right with no pain. 1-3 = mild pain,4-6 = moderate pain,7-10 = severe
      pain.

      The evaluation of neuropathy was done by using the Michigan Neuropathy Screening Instrument
      (MNSI) after translation to the Arabic language.which consists a 15 self-administered
      questionnaires and examination lower extremities which comprise inspection and examination of
      vibratory senses and ankle reflexes. A score which is more than 7 was suggested to be
      abnormal.
    

Intervention name(s): GLUCOSE 10%
Intervention type(s): Drug
Intervention description(s): subcutaneous glucose 0.5 ml per site around subcutaneous nerves
Other intervention name(s): dextrose 10%
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        100 patients of type 1 and type 2 diabetes mellitus in 2 groups each group 50 patients,
        each group 30 males, and 20 females,35 patients with type 2 diabetes and 15 patients type 1
        diabetes all have diabetic peripheral neuropathy, the second group is considered as
        control. the ages of all patients are between 20 and 50 years.
      
Keywords: diabetes mellitus; diabetic neuropathy; pain; glucose 10%
Acceptance and Usability of an App Promoting Healthy Behaviours Amongst Young Women at Increased Risk of Breast Cancer
Condition: Breast Cancer; Overweight and Obesity; Diet, Healthy; Weight Gain; Alcohol Drinking; Smoking Behaviors; Healthy Nutrition; Healthy Lifestyle; Healthy Eating Index
MeSH terms: Breast Neoplasms; Overweight; Weight Gain; Alcohol Drinking
Study type: Interventional

Summary: 
      It is estimated that around 20% of breast cancers (BC) in the UK are preventable through
      adherence to appropriate health behaviours, i.e., healthy diet, physical activity, limited
      alcohol, not smoking, and that women at increased risk of BC could benefit from greater
      decreases in risk than the general population via health behaviour changes. Young women (age
      <35 years) who are at increased risk of developing BC currently receive little or no
      information regarding health behaviours and BC risk, or support for behaviour change. This
      feasibility study aims to explore whether a novel app is acceptable to women at increased
      risk and could potentially engage them with improved health behaviours which could reduce
      their future risk of BC.
    

Detailed description: 
      Aims

        1. To assess the acceptability and usability of the app to young women at increased risk of
           BC

        2. To assess the feasibility of study procedures before running a future efficacy study
           using the app as an intervention

      Objectives

        1. Explore views of users of the experiences during and after using the app

        2. Explore views of users on their experience of the two different recruitment procedures
           (targeted mailshot, or social media, newsletters and websites), and the online consent
           procedure.

        3. Interpret user data from the app including frequency and patterns of use of the
           different functions

        4. Analyse recruitment data to explore how the two different recruitment procedures could
           be improved for the next study

        5. Assemble a list of suggested changes to recruitment and consent procedures, and to the
           app, to be considered before the next study.

        6. Quantify health care professional (HCP) time required for administering the private
           Facebook chat group, and through e-mail/private message support.

        7. Quantify researcher time required for cleaning and analysis of app data.
    

Intervention name(s): App Promoting Healthy Behaviours
Intervention type(s): Behavioral
Intervention description(s): Women on the study will receive two months access to the app.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
A Clinical Evaluation of a Novel Multi-Wavelength Laser for Benign Pigmented Lesion Removal
Condition: Pigmented Skin Lesion of Suspected Benign Nature
MeSH terms: Pigmentation Disorders
Study type: Interventional

Summary: 
      To evaluate the safety and efficacy of an investigational version of the Cutera enlightenTM
      laser that offers multiple wavelengths for removal of benign pigmented lesions.
    

Detailed description: 
      The purpose of this investigation is to evaluate the safety and efficacy of an
      investigational version of the Cutera enlightenTM laser for benign pigmented lesion (BPL)
      removal. Currently, the enlightenTM laser offers two wavelengths: 532nm KTP and 1064nm
      Nd:YAG. The version of the laser under investigation allows the user to choose from a range
      of wavelengths.
    

Intervention name(s): Investigational Enlighten Device
Intervention type(s): Device
Intervention description(s): Up to 3 laser treatments, spaced 4 to 6 weeks apart
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
PACE Vape Messaging Study
Condition: Vaping; E-cigarette Use; Electronic Cigarette Use
Study type: Interventional

Summary: 
      The purpose of this study is to examine the effect of exposure to vape education messages on
      beliefs, perceptions, norms, and behaviors related to electronic vapor product use.
    

Detailed description: 
      Using content developed from the formative research phase, participants in this randomized
      controlled trial will either be exposed to ten vape education messages or to ten messages on
      sun safety, with all messages formatted for social media.

      This study will take place over a 1-month period. Individuals who complete the screening
      survey and are eligible to participate will be invited to complete a 10-15 minute baseline
      survey at the start of the study. This survey will ask questions about tobacco and electronic
      vapor product use, and beliefs about and perceptions of vape products. This survey will also
      ask about exposure to tobacco and e-cigarette marketing, exposure to prevention messaging on
      vaping and tobacco use, and peer and family influences on tobacco use. During the survey,
      participants will be presented with and be asked to provide feedback for short health-related
      messages.

      One month after completing this survey, participants will be sent an invitation to the
      follow-up survey. This survey will again ask about tobacco and electronic vapor product use,
      and beliefs about and perceptions of vape products.

      All study procedures will take place remotely, with surveys conducted online. At the end of
      the first survey, participants will be eligible to receive a $10 online gift card. Upon
      completion of the follow-up survey, participants will be eligible to receive a $15 online
      gift card. In total, participants will be eligible to receive up to $25 for completing both
      surveys. Those who are ineligible will not be asked to complete the baseline survey and will
      not be compensated.
    

Intervention name(s): Vape Messaging Intervention
Intervention type(s): Behavioral
Intervention description(s): Participants will be exposed to 10 vape education messages
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: surveys; vaping
Postoperative Pain Therapy With Hydromorphone TCI-PCA vs. Morphine PCA
Condition: Acute Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional
Phase: Phase 4

Summary: 
      Treatment of postoperative pain with hydromorphone (a strong analgesic) using
      patient-controlled analgesia with target-controlled infusion compared to conventional
      patient-controlled analgesia with morphine after elective cardiac surgery
    


Intervention name(s): Hydromorphone; Morphine
Intervention type(s): Drug; Drug
Intervention description(s): Hydromorphone is given intravenously by TCI-PCA. The TCI-PCA system steer the hydromorphone infusion pump to achieve plasma and effect-site concentrations of hydromorphone in predefined increasing steps on patient request and in predefined decreasing steps on lack of patient request within predefined plasma and effect-site concentration range, lockout times and infusion speed.; Morphine is given intravenously by PCA. The PCA pump administers a predefined bolus dose on patient request considering the predefined lockout time and infusion speed.
Intervention MeSH terms: Morphine; Hydromorphone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
PK and PD Crossover Study After Single Dose, Intravenous Administration of Two Epoetin Alfa, Human Recombinant Epoetin and Eprex, in Healthy Subjects.
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The hypothesis of this trial is that the test drug (Eritromax ®) pharmacokinetics and
      pharmacodynamics parameters are similar to the comparator drug (Eprex ®) in healthy subjects
      following administration of single intravenous dose. The objective of this randomized,
      crossover, clinical trial is to evaluate the pharmacokinetic and pharmacodynamic profile of
      the drug Eritromax® marketed by Blau Farmacêutica, compared to the product Eprex ®, produced
      by Janssen-Cilag, by assessing plasma concentration of the drug and the reticulocyte count
      following a single-dose intravenous administration of 100 IU/kg in healthy subjects.
    


Intervention name(s): Epoetin Alfa
Intervention type(s): Drug
Intervention description(s): Intravenous single-dose administration of 100 IU/kg of the test drug (Human Recombinant Epoetin) in the first period and intravenous single-dose administration of 100 IU/kg of the comparator drug (Eprex) in the second period, after 23-30 days of washout, or vice-versa.
Other intervention name(s): Eprex
Intervention MeSH terms: Epoetin Alfa
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: subject
Safety and Efficacy of ADDERALL XR in the Treatment of Adolescents Aged 13-17 With Attention Deficit Hyperactivity Disorder (ADHD)
Condition: ADHD
Study type: Interventional
Phase: Phase 3

Summary: 
      Assess the safety and efficacy of ADDERALL XR compared to placebo in the treatment of
      adolescents (aged 13-17) with ADHD. Subjects were assigned to one of two cohorts based on
      weight (<= 75 kg or > 75 kg).
    


Intervention name(s): Mixed salts of a single-entity amphetamine (ADDERALL XR); Placebo
Intervention type(s): Drug; Drug
Intervention MeSH terms: Amphetamine; Adderall
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Vitamin D Pilot Study in Patients With Multiple Sclerosis
Condition: Relapsing Remitting Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Sclerosis
Study type: Interventional
Phase: Phase 1

Summary: 
      Phase 1 study of 19-nor Vitamin D in relapsing-remitting MS. Primary measure is MRI.
    


Intervention name(s): 19 nor vitamin d
Intervention type(s): Drug
Intervention MeSH terms: Vitamin D
Intervention model: Single Group Assignment
Primary purpose: Treatment
Keywords: Vitamin D, 19 nor Vitamin D, Multiple Sclerosis
Improving HbA1c Levels by Methylcobalamin Vitamin in Diabetic Volunteers
Condition: Diabetes Mellitus
MeSH terms: Diabetes Mellitus
Study type: Interventional

Summary: 
      The current study was conducted to evaluate the prognostic implications of vitamin B12
      admission on BMI and HbA1c levels in type 2 diabetic patients treated with Dapagliflozin as a
      routine medication.
    

Detailed description: 
      Eighty diabetic patients were enrolled in this study; 37 females and 43 males with inclusion
      criteria of vitamin B12 levels less than 233 ng/ml. The participants were divided into two
      groups, the Dapagliflozin group (active comparator group) received only the
      diabetic-controlling drug Dapagliflozin 10 mg/daily orally for twelve months, whereas,
      vitamin B12 and Dapagliflozin group (Experimental group) received Vit. B12 supplements as
      methylcobalamin 500 µg orally once daily with Dapagliflozin 10 mg/daily orally for twelve
      months. Glycemic control was measured by monitoring levels of HbA1c and Vitamin B12 in the
      participant's blood four times at time intervals of three months during the study period.
      Additionally, the weight measurements were recorded during the study period at time intervals
      of three months and BMI was calculated. The data obtained was treated by statistical analysis
      using SPSS software (version 20) for the significant correlation of the independent variables
      of the study groups after vitamin B12 supplementation.
    

Intervention name(s): Vitamin B12 0.5 MG/ACTUAT; Dapagliflozin 10mg Tab
Intervention type(s): Drug; Drug
Intervention description(s): The investigators measured the blood levels of Vitamin B12 and HbA1c as well as the BMI in two study groups; The Experimental group: Vitamin B12 and Dapagliflozin group and Active Comparator group: Dapagliflozin group.
The Dapagliflozin group received only Dapagliflozin 10 mg/daily orally for twelve months, whereas, the Vitamin B12 and Dapagliflozin group received Vit. B12 supplements methylcobalamin 500 µg once daily orally with the anti-diabetic therapy Dapagliflozin 10 mg/daily orally for twelve months.; The investigators measured the blood levels of Vitamin B12 and HbA1c as well as the BMI in two study groups; The Experimental group: Vitamin B12 and Dapagliflozin group and Active Comparator group: Dapagliflozin group.
The Dapagliflozin group received only Dapagliflozin 10 mg/daily orally for twelve months, whereas, the Vitamin B12 and Dapagliflozin group received Vit. B12 supplements methylcobalamin 500 µg once daily orally with the anti-diabetic therapy Dapagliflozin 10 mg/daily orally for twelve months.
Intervention MeSH terms: Vitamin B 12; Hydroxocobalamin; Dapagliflozin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Cleft Palate With Intravelar Veloplasty Repair
Condition: Cleft Palate
MeSH terms: Cleft Palate
Study type: Interventional

Summary: 
      Cleft palate repair is the most important component of cleft surgery, not only in that it
      determines the outcome as far as speech and communication are concerned, but also in that it
      potentially has the greatest impact on maxillary growth and the dental arch relationship.
      Sommerlad technique has been described as a more physiological approach, aiming to restore
      the anatomy of the velum. This technique, often described as radical intravelar veloplasty,
      has the following distinctive components: a radical retroposition of velar musculature (m.
      levator veli palatini, m. palatoglossus, and m. palatopharyngeus), combined with minimal
      dissection of the hard palate, a tensor tenotomy, and the repair of the m. levator sling
    


Intervention name(s): Repair of cleft palate with intravelar veloplasty (IVVP)
Intervention type(s): Procedure
Intervention description(s): A triangular flap is designed comprising new epithelial tissue which will be turned over to help close the nasal mucosa. Using a single hook, the oral mucosa and gland layer is separated from the muscle layer. Dissection of the greater palatine nerve-vessel bundle. The anterior palatal flap is raised by a curved elevator. The closure of the nasal mucosa and muscle is completed. Dissection of Velo Palatine Levator begins from the posterior rim of muscle and 5 mm from the midline.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
BI 671800 ED in Steroid-naive Asthmatic Patients
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a 6 week study to investigate the effectiveness and safety of BI 671800 ED in
      patients with asthma who do not take inhaled corticosteroids.
    


Intervention name(s): BI 671800; Fluticasone propionate placebo; Fluticasone propionate; BI 671800 Placebo
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): BI 671800; Placebo matching Fluticasone propionate; Fluticasone propionate; Placebo matching BI 671800
Intervention MeSH terms: Fluticasone; Xhance
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Dissemination and Implementation of Stroke Prevention Looking at the Care Environment
Condition: Sickle Cell Disease
MeSH terms: Anemia, Sickle Cell
Study type: Interventional

Summary: 
      The Dissemination and Implementation of Stroke Prevention Looking at the Care Environment
      (DISPLACE) study is a multi-center, national, National Heart, Lung and Blood Institute
      (NHLBI)-funded grant to look at the real-world implementation of stroke prevention guidelines
      (STOP Protocol) in which transcranial Doppler (TCD), a measure of cerebral blood vessel
      velocity, is used to screen for stroke risk in children ages 2-16 with sickle cell anemia
      (SCA). Part 3 of the DISPLACE study is an implementation clinical trial designed to test
      novel implementation strategies with the goal of improving adherence and implementation of
      stroke screening. 16 of the lowest scoring implementation rates from DISPLACE Part 1 will
      participate in DISPLACE Part 3. All original 28 sites from DISPLACE Parts 1 and 2 will
      receive a patient and provider educational intervention including a re-branding of the TCD as
      "Sickle Stroke Screen" with a new infographic and educational materials. The 16 sites with
      moving to Part 3 will be provided a Provider reminder strategy, which is a web based
      application designed to remind providers of when patients are due for their Sickle Stroke
      Screen. These 16 sites will be randomized and 8 will be given an additional Patient
      Communication Strategy. These sites will have a single designed coordinator with whom
      patients will communicate with about scheduling, rescheduling, and any other questions
      regarding their Sickle Stroke Screen. Upon completion, data will be analyzed to compare those
      who have had TCD screenings done appropriately and those who did not as well as the overall
      effect of the multi level interventions on the changes in TCD rates.
    


Intervention name(s): Provider-level intervention; Patient-level intervention
Intervention type(s): Other; Other
Intervention description(s): Provider minder is a provider-based scheduling and reminder system for stroke screening in SCD; 50% of centers are randomized to a single stroke screen coordinator as the point of contact for sickle stroke screen
Other intervention name(s): Provider Minder; Single Coordinator
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized cluster controlled implementation study
Masking: None (Open Label)
Primary purpose: Other
Genius Toothbrushes on Periodontal Status of Orthodontic Patients
Condition: Periodontal Inflammation; Toothbrushing; Orthodontic Treatment
MeSH terms: Inflammation
Study type: Interventional

Summary: 
      This study evaluates the effects of genius toothbrushes on periodontal status of patients
      during fixed orthodontic treatment.Half of the patients received manual orthodontic
      toothbrushes (Oral B Ortho, Procter & Gamble, USA) with V-shaped bristles and rounded ends.
      The others received genius orthodontic toothbrush (Oral B Genius 8900, Procter & Gamble, USA)
      with Oral-B CrossAction brush head, Procter & Gamble, USA).
    

Detailed description: 
      Powered (genius) toothbrush with position detection technology provides patient to clean all
      areas of the mouth during the required time. By connecting phone to the Oral-B App, the
      genius toothbrush uses facial recognition technology to guide patient's brushing, zone to
      zone. Pressure control and personalization are another characteristics of these toothbrushes.
      Pressure sensor alerts patient if the brushing is too hard and helps her/him not to put too
      much pressure by reducing the speed of brush head. Due to the Bluetooth technology,
      toothbrushing can be performed more efficiently among orthodontic adolescent patients. In
      addition, the position detection and timer can be used to control which area is brushed in
      the mouth and how much total brushing time is continued. The application allows patient to
      see all the days brushing activity and real-time feedback on brushing habits can be received
      by this way.
    

Intervention name(s): Genius toothbrush; Manual toothbrush
Intervention type(s): Device; Device
Intervention description(s): Patients brushed their teeth twice a day for 2 minutes. An integral timer was used in the genius toothbrush group.; Patients brushed their teeth twice a day for 2 minutes. During brushing, patients in manual group assigned to use their brushes were provided with a digital timer.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Other
Keywords: Genius toothbrush; Orthodontic treatment; Periodontal health