Contribution of Inflammation and Neuronal Integrity Markers in Patients With First-episode Conversive Motor Disorder
Condition: Conversion Disorder
MeSH terms: Inflammation; Motor Disorders; Conversion Disorder; Hysteria; Dissociative Disorders
Study type: Observational

Summary: 
      Conversion disorders, also called "dissociative disorders" (ICD-10), or "functional
      neurological disorders" (DSM-5), are a common condition, with a prevalence of 1-10% in
      medical and surgical inpatients (Toone 1990), and 10-30% in neurology patients (Carson et al.
      2000).

      They are characterized by the presence of symptoms or deficits affecting voluntary motor,
      sensory, or sensory functions suggestive of a neurological or general medical condition in
      combination with psychological factors. Functional neurological disorder is currently a
      diagnosis of elimination and its treatment remains uncodified. A better understanding of the
      pathophysiology of this disorder is needed to improve the diagnostic and therapeutic approach
      to this condition.

      Identifying new biological markers associated with motor symptoms occurring during the course
      of the functional neurological disorder would allow clinicians to acquire new diagnostic
      methods, to improve therapeutic means and their specificity and to highlight possible
      predictive factors of the clinical evolution of this pathology. At the same time, the
      identification of biological markers associated with motor symptoms will allow the patient to
      better understand and accept the diagnosis, and thus to better adhere to the proposed
      treatment.
    

Detailed description: 
      This project is an ancillary study carried out from the cohort of patients included in the
      HYCORE protocol "PET-Scan evaluation of metabolic abnormalities associated with the clinical
      evolution at 6 months of patients suffering from a motor conversion disorder" (RCB N°:
      2014-A01159-38) of which the CHU of Nîmes is the promoter. In the HYCORE project, 20 patients
      suffering from a first episode of motor conversion disorder (with paralysis, motor weakness
      or abnormal movements according to DSM-IV criteria) in acute phase (evolving for less than
      one month) recruited in the neurology and psychiatry departments of the University Hospital
      of Montpellier and Nîmes are included.

      Thinvestigtor plan to use the biological samples collected in the HYCORE project for the
      determination of markers of inflammation and neurofilaments (GFAP & NfL); the levels of
      inflammatory markers thus obtained will be put into perspective in relation to the cerebral
      metabolism observed by PET-scan as well as the persistence of a motor handicap (EDSS score)
      evaluated in the HYCORE study.
    

Intervention name(s): blood inflammatory markers (TNF-α, IL1ra, RsIL-2, IL-6, IL-10, IL-18, IFNγ, MCP-1/CCL2 GFAP)
Intervention type(s): Diagnostic Test
Intervention description(s): Bioassays of blood inflammatory markers (TNF-α, IL1ra, RsIL-2, IL-6, IL-10, IL-18, IFNγ, MCP-1/CCL2 GFAP) from sera babcocked in the HYCORE mother study.
Intervention MeSH terms: Interleukin 1 Receptor Antagonist Protein
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        20 patients with paralysis, motor weakness or abnormal movements corresponding to the
        DSM-IV criteria of conversive motor disorder consulting the SAU or the Neurology
        departments of the CHU of Nîmes and Montpellier already included in the HYCORE mother
        study.