bioihbjkbjnl/mcl2 huggingface dataset:
Waist Circumference Versus Body Mass Index to Predict Severity of Gastroesophageal Reflux Disease
Condition: Gastroesophageal Reflux Disease; Obesity
MeSH terms: Gastroesophageal Reflux; Esophagitis, Peptic
Study type: Observational

Summary: 
      Gastroesophageal reflux disease (GERD) is a common and important disorder. Previous studies
      have demonstrated the association of obesity with GERD, and now obesity is regarded as a risk
      factor for GERD. Moreover, body mass index (BMI), an indicator of general obesity, correlates
      with severity of symptoms and degree of erosive esophagitis. Waist circumference, an
      indicator of abdominal obesity, has stronger correlation with intra-abdominal pressure and
      low-grade inflammatory state when compared with BMI. Nevertheless the association of waist
      circumference with severity of GERD has not been studied.

      The primary aim of this study is to compare BMI with waist circumference for their
      independent association with severity of GERD. The secondary aim is to evaluate independent
      risk factors of severity of GERD.
    

Detailed description: 
      This is a cross-section observational study. Outpatients presenting with acid reflux or heart
      burn are interviewed with standardized questionnaire to quantify severity of symptoms. The
      eligible patients undergo upper endoscopy to diagnose erosive esophagitis and further
      classify the degree of erosions according to Los-Angels classification. Enrolled patients
      receive anthropometric measurements to record body weight, body height and waist
      circumference on the day of enrollment.

      Two outcomes are studied: the severity of GERD symptoms and the Los-Angels Classification of
      erosive esophagitis.
    

Intervention name(s): Anthropometric measurements
Intervention type(s): Other
Intervention description(s): All patients undergo anthropometric measurements to record body weight, body height and waist circumference on the day of enrollment
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Outpatients at a general hospital with 1000 beds in north-eastern Taiwan
      
Keywords: Gastroesophageal reflux disease; Waist circumference; Body mass index; Obesity
Effect of Whole-body Vibration on the Ankle Joint, Plantar Pressure, and Running Paramethers
Condition: Range of Motion; Running; Gait
Study type: Interventional

Summary: 
      The main purpose of this study was the assessment of whole-body vibration warm-up, modified
      drop jumps, and combination of both on the range of motion of dorsiflexion in the ankle joint
      and running time. 16 recreationally active runners performed 4 different warm-up variants one
      week apart: 5 sets of 30 s calf raises on the platform but without vibration (CTRL), the same
      as CTRL group but with vibration with 30 s rest intervals between sets (WBV), 6 drop jumps
      with a 30 s rest interval between sets (DJ); last group was combination of both WBV and DJ
      groups (WBV+DJ). The study included muscle flexibility tests for the soleus and gastrocnemius
      muscles performed before the warm-up, 3 minutes after warm-up and immediately after a 3000 m
      run on a treadmill. The running time was measured and the run had to be completed in the
      shortest possible time.

      Additionally, in the third week of the study there were performed static and dynamic foot
      measurements immediately before and after a 3000 m treadmill run. The main purpose of that
      gait analysis was to assess the impact of a 3km run on plantar pressure patterns and gait
      parameters in recreational runners.
    


Intervention name(s): LADY 1 Pro, New Life Balance; exercises
Intervention type(s): Device; Other
Intervention description(s): whole-body vibration training on the platform; calf raises and modified drop jumps
Intervention model: Single Group Assignment
Intervention model description: The participants engaged in four experimental sessions within 4 weeks. These sessions were conducted in a randomized sequence, with a one-week gap between each session. During each session, every participant performed one of the following tasks: 5 sets of 30 s calf raises on the platform but without vibration (CTRL); 5 sets of 30 s calf raises on the vibration platform with 30 s rest intervals between sets (WBV); 6 drop jump with a 30 s rest interval between sets (DJ); 5 sets of 30 s calf raises on the vibration platform followed by 6 drop jumps with a 30 s rest interval between sets (WBV + DJ).
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: runners; muscle flexibility; ankle; range of motion; foot arches; plantar pressure patterns; Footscan
Efficacy of Duloxetine Compared to NSIADs in Osteoarthritis of Knee
Condition: Osteo Arthritis Knee
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional
Phase: Phase 2

Summary: 
      Osteoarthritis (OA) is the most common degenerative joint disease, affecting more than 25% of
      the population . Knee OA is an insidious disease related to structural changes in the joint
      over many years. Progressive articular damage results in a loss of the extracellular matrix
      of cartilage in addition to changes in subchondral bone.

      Duloxetine, a selective serotonin, and norepinephrine reuptake inhibitor, it seems to be
      effective in treating neuropathic and chronic pain conditions.
    

Detailed description: 
      This will be a 13-week A randomized open labelled clinical trail in Iraqi Kurdistan Region,
      that will be designed to assess the efficacy of duloxetine tablet compared with other group
      (Nonsteroidal anti-inflammatory) drug on the reduction of pain caused by osteoarthritis of
      the knee.

      Patients will be divided into two groups, first group (case) will receive duloxetine tablet
      30mg for two weeks then titrated up to duloxetine 30mg BID. Patients will be instructed to
      take the medication with meals. Patients will be observed at visits (0) baseline then at
      second visits at 13 weeks then will be compared to control group that will receive NSAID
      (nonsteroidal anti-inflammatory drug) at baseline (0) visit then 2nd visits at 13 weeks.
    

Intervention name(s): Duloxetine 30 MG; Nonsteroidal Antiinflammatory Drug
Intervention type(s): Drug; Drug
Intervention description(s): patient in first group (case) will receive duloxetine tablet 30mg for two weeks then titrated up to duloxetine 30mg BID. Patients will be instructed to take the medication with meals. The for 13 weeks; patient in this second group will receive NSAID for 3 weeks
Other intervention name(s): Cymbalta; NSAID
Intervention MeSH terms: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Duloxetine Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Patients will be divided into two groups, first group (case) will receive duloxetine tablet 30mg for two weeks then titrated up to duloxetine 30mg BID. Patients will be instructed to take the medication with meals.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Duloxetine, Osteoarthritis, Kurdistan Region
Intraosseous Infusion for Neonatal Asphyxiated Resuscitation
Condition: Asphyxia Neonatorum
MeSH terms: Asphyxia Neonatorum; Asphyxia
Study type: Interventional

Summary: 
      Intraosseous infusion is better than umbilical vein infusion for neonatal asphyxiated
      resuscitation
    


Intervention name(s): Intraosseous infusion; Umbilical vein infusion
Intervention type(s): Procedure; Procedure
Intervention description(s): Using intraosseous infusion for resustation in this group; Using umbilical vein infusion for resustation in this group
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Supportive Care
Dysport® Adult Upper Limb Spasticity
Condition: Nervous System Disorders
MeSH terms: Nervous System Diseases
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this research study is to assess the efficacy of Dysport compared to placebo
      in improving muscle tone in hemiparetic subjects with upper limb spasticity due to stroke or
      traumatic brain injury.
    


Intervention name(s): Botulinum toxin type A; Botulinum toxin type A; Placebo
Intervention type(s): Biological; Biological; Drug
Intervention description(s): 500 U, I.M. (in the muscle) injection on day 1 of a single treatment cycle.; 1000 U, I.M. (in the muscle) injection on day 1 of a single treatment cycle.; I.M. (in the muscle) injection on day 1 of a single treatment cycle.
Other intervention name(s): AbobotulinumtoxinA (Dysport®); AbobotulinumtoxinA (Dysport®)
Intervention MeSH terms: Botulinum Toxins; Botulinum Toxins, Type A; abobotulinumtoxinA
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Assessment of Arterial Dynamic Elastance as a Function Variable of Arterial Load
Condition: Hypovolemia
MeSH terms: Hypovolemia
Study type: Interventional

Summary: 
      The goal of the study is to determine Eadyn as a functional measure of arterial load, in
      conjunction with other actual afterload indices, derived from both invasive arterial pressure
      tracing and non-invasive signals, such as arterial saturation, non-invasive cardiac output
      obtained by bio-reactance, and non-invasive stroke volume. A secondary aim is the correlation
      of the different non-invasive signals with the invasive arterial pressure tracing
      characteristics.
    

Detailed description: 
      Fifteen patients, who provide written informed consent, will be included. All of them are
      scheduled for a major surgical intervention, in whom standard haemodynamic monitoring
      includes arterial pressure monitoring.

      Non-invasive wired patches, connected to a Cheetah cardiac output monitor, will be installed,
      as well as traditional haemodynamic monitoring (ECG, SaO2, non-invasive blood pressure). A
      computer link between a Philips monitor (MP50 or MP70) is made, to obtain selected curves in
      a digital format for post-intervention processing. After awake insertion of an arterial
      catheter in the radial or brachial artery and induction of anaesthesia, patient becomes
      intubated and mechanically ventilated.

      Before surgery, following data will be registered for 5 min.: ECG, invasive arterial pressure
      tracing, cardiac output (Cheetah monitor), SaO2 tracing, arterial pressure tracing and pulse
      pressure and stroke volume variation (Nexfin).

      When SVV > 15%, the operation table will be put in Passive Leg Raising (PLR) to optimize the
      filling status of the patient (test of preload dependency). When positive haemodynamic
      reaction is present, the patients will obtain a rapid infusion bolus of 250 ml of
      crystalloids.
    

Intervention name(s): arterial line; Cheetah®
Intervention type(s): Device; Device
Intervention description(s): In mechanically ventilated patients systolic pressure variation will be captured and passive leg raising with positive result fluid filling will be initiated.; In mechanically ventilated patients systolic pressure variation will be captured and passive leg raising with positive result fluid filling will be initiated.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: elastance; fluid responsiveness
Aging and Estrogen on Cortical Function
Condition: Memory Loss; Cognitive Changes; Postmenopausal Symptoms
MeSH terms: Memory Disorders
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This study will focus on how estrogen affects parts of the brain associated with memory and
      how the effect of estrogen is altered with aging in postmenopausal women.
    

Detailed description: 
      The broad goal of this proposal is to determine the effect of aging on areas of the brain
      whose function is impacted by gonadal steroids in women. The overarching hypothesis is that
      aging differentially alters the effects of estrogen on the brain. Our preliminary data
      indicated that aging alters the effect of estrogen on brain regions involved in cognition and
      thus, the current study focused on the impact of aging on functional changes induced by
      estrogen in cortical and subcortical areas associated with verbal working memory and
      declarative/episodic memory.

      As our model, we will use women in whom the absence of gonadal function makes it possible to
      control the duration and amount of estrogen exposure, specifically postmenopausal women who
      are younger (45-55) or older (65-80) who receive either oral or transdermal estradiol to
      achieve premenopausal early follicular phase estradiol levels.. We evaluate the effects of
      low dose estrogen exposure at 48 hr and 1 month to determine whether the short-term changes
      in brain regions involved in cognition with low dose estrogen exposure seen in our
      preliminary studies are confirmed and whether changes with short-term estrogen exposure
      persist with more prolonged exposure, a finding that would have enormous clinical relevance.
      These studies, using sophisticated neuroimaging tools (structural and functional magnetic
      resonance imaging [MRI] and [18F] 2-fluoro-2-deoxy-D-glucose positron emission tomography
      [FDG-PET]), provide a unique window into the brain in women.
    

Intervention name(s): Estradiol oral capsule; transderman estrogen patch; trasdermal placebo patch; placebo oral capsule
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): 1 oral capsule (1 mg estradiol) administered daily for one month; transdermal estrogen patch (50 mcg/day) for one month; transdermal placebo patch with patch change every 84 hr for one month; placebo oral capsule administered daily for one month.
Other intervention name(s): Micronized Estradiol; Estradiol; Climara; Estraderm; Estrogen patch; Placebo patch; Placebo capsule
Intervention MeSH terms: Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol; Polyestradiol phosphate; Estrogens
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Each participant was randomized to placebo or estrogen using a block randomized design by age group
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
Keywords: aging; postmenopausal women; estrogen; memory
The Efficacy of Midazolam & Ketamine Versus Midazolam & Fentanyl for Sedation in Ambulatory Colonoscopies
Condition: Colonoscopy; Conscious Sedation
Study type: Interventional
Phase: Phase 4

Summary: 
      Providing adequate sedation and analgesia is an integral part of the practice of colonoscopy
      procedure.

      There are various protocols and methods used to prevent discomfort and alleviate pain.
      Conscious sedation is one of the options recommended by the American Society for
      Gastrointestinal Endoscopy, although the choice of the exact protocol is left to the
      physician's discretion.

      This study will attempt to recommend a preferred protocol based on a double blind randomized
      prospective method.

      The efficacy of midazolam and ketamine will be compared to the efficacy of midazolam and
      fentanyl for sedation in ambulatory colonoscopies.

      The results will be compiled from objective data and patient and physician interviews.
    


Intervention name(s): Midazolam, Fentanyl; KETAMINE, MIDAZOLAM
Intervention type(s): Drug; Drug
Intervention description(s): fentanyl 0.07 mcg/kg + midazolam 0.05 mg/kg if needed adding midazolam up to a total of 0.1 mg/kg; Ketamine 0.25 mg/kg + midazolam 0.05 mg/kg if needed adding midazolam up to a total of 0.1 mg/kg
Intervention MeSH terms: Midazolam; Fentanyl; Ketamine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: colonoscopy; conscious sedation; midazolam; ketamine; fentanyl
Step Away From Depression - Evaluation of a Pedometer Intervention With Inpatients With Major Depression
Condition: Depression
MeSH terms: Depression; Depressive Disorder
Study type: Interventional

Summary: 
      The purpose of this study is to determine if the use of pedometers can help depressive
      inpatients in psychiatric clinics to increase their level of physical activity. Therefore
      patients are given a pedometer and instructions how to raise their level of daily steps.
      Intervention group is compared with a control group that is receiving treatment-as-usual. The
      intervention is hypothesized to increase number of daily steps and have positive effects on
      mood, depression and anxiety.
    


Intervention name(s): Pedometer
Intervention type(s): Device
Intervention description(s): Patients receive a pedometer with instructions how to raise their number of daily steps
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Physical Activity; Mental Health; Health Behavior; Walking; Physical Exercise; Mental disorder
Cardiac Function in Severe Aneurysmal Subarachnoid Haemorrhage Patients
Condition: Aneurysmal Subarachnoid Haemorrhage; World Neurosurgeon Federation Score ≥ III
MeSH terms: Subarachnoid Hemorrhage; Hemorrhage
Study type: Observational [Patient Registry]

Summary: 
      Cardiac dysfunction can occur in aneurysmal subarachnoid haemorrhage and might impact
      patient's neurologic outcome Condition Aneurysmal subarachnoid haemorrhage World Neurosurgeon
      Federation Score ≥ III
    

Detailed description: 
      Trans-thoracic echocardiography on day 1, day 3 and day 7 Speckle-Tracking of
      echocardiographic loops by a cardiologist blinded to the patient's management and outcome
    

Intervention name(s): Echocardiography
Intervention type(s): Procedure
Intervention description(s): Speckle-Tracking of echocardiographic loops by a cardiologist blinded to the patient's management and outcome
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Severe Aneurysmal subarachnoid haemorrhage
      
Keywords: Aneurysmal subarachnoid haemorrhage
Healthy Eating Better Breathing: A Feeding Study in Patients With Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional

Summary: 
      The study is a randomized, crossover meal-replacement pilot intervention to determine
      feasibility of a larger scale dietary trial in asthma and gather preliminary evidence for the
      impact of a healthy diet on asthma outcomes. Participants with doctor-diagnosed asthma were
      randomized to crossover trial of a 4-week dietary intervention or usual diet with a 4-week
      washout period. During the dietary intervention, all meals and snacks were provided by the
      study.
    

Detailed description: 
      The objective of the study is to demonstrate feasibility of a randomized, controlled clinical
      trial of a dietary intervention in a population of adults with asthma and to determine sample
      size estimates for a larger, more definitive trial aimed at improving asthma clinical
      outcomes and improving markers of inflammation and oxidative stress. The study uses a feeding
      trial design comprised of a 4 week dietary intervention in which all meals are provided to
      study participants and a 4 week control diet comprised of usual dietary intake. Participants
      are randomized to the intervention or control diet and then cross over to the alternate
      assignment after a 4 week washout period.
    

Intervention name(s): healthy diet
Intervention type(s): Other
Intervention description(s): Participants were provided meals and snacks for one month that represented a healthy diet that is high in unsaturated fats, approximating a Mediterranean diet
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Study to Assess the Safety and Tolerability of Idebenone in the Treatment of Friedreich's Ataxia Patients
Condition: Friedreich's Ataxia
MeSH terms: Ataxia; Cerebellar Ataxia; Friedreich Ataxia
Study type: Interventional
Phase: Phase 3

Summary: 
      This study is meant to assess the safety and tolerability of idebenone in patients with
      Friedreich's Ataxia over a 12 months period.
    

Detailed description: 
      The study involves 6 clinic visits.
    

Intervention name(s): Idebenone
Intervention type(s): Drug
Intervention description(s): Patients ≤ 45 kg/99 lbs: idebenone 1350 mg/day; Patients > 45 kg/99 lbs: idebenone 2250 mg/day
Intervention MeSH terms: Idebenone
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Friedreich's Ataxia; Idebenone; ICARS
A Phase III Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes Who Are Not Well Controlled With Diet and Exercise
Condition: Type 2 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this clinical research study is to determine whether dapagliflozin can improve
      (decrease) blood glucose values in patients with Type 2 diabetes who have never been treated
      with medication or have been taking medication for less than 24 weeks since their original
      diabetes diagnosis. The safety of this treatment will also be studied.
    

Detailed description: 
      All eligible participants will receive single-blind placebo medication during the 2-week
      lead-in period. All participants may receive additional open-label treatment with metformin,
      500-2000 mg, as needed for rescue, based on protocol specific criteria.
    

Intervention name(s): Dapagliflozin; Dapagliflozin placebo; Metformin
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Tablets; oral; 2.5, 5.0, or 10 mg; once daily in the morning or evening for up to 102 weeks; Tablets, oral, 0 mg, once daily in the morning or evening for up to 102 weeks
Other intervention name(s): BMS-512148; Tablets, 500-2000 mg, orally as needed in any arm for rescue, based on protocol specific criteria
Intervention MeSH terms: Metformin; Dapagliflozin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Yoga Exercise for Improving Balance in Patients With Subacute &Ｃhronic Stroke
Condition: Depression; Stroke
MeSH terms: Stroke; Depression
Study type: Interventional

Summary: 
      Hypothesis: This study investigated the hypothesis that subacute and chronic stroke patients
      who received a combination of yoga and traditional physiotherapy were getting more
      improvement in standing balance than traditional physiotherapy. And we also hypothesis yoga
      can improve post-stroke depression symtom.
    


Intervention name(s): Yoga
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Yoga; Stroke; Standing balance; Depression