Nutrigenomics And Children Obesity: A Moderate Weight Loss Intervention Study
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional

Summary: 
      The consumption of diets enriched in proteins (legumes and fish) or antioxidant (fruits and
      vegetables) could have beneficial effects beyond those of the caloric restriction on
      biomarkers of the inflammatory and oxidative status. OBJECTIVE: To address the effect of a
      10-week dietary intervention aimed to weight loss in obese or overweight children (7-15 aged)
      on genomics, particularly the changes in the expression of genes related to the inflammatory
      status and oxidative stress. METHODOLOGY: 44 Navarra children and adolescents of both sexes
      from Pediatric Endocrinology Services at different Hospitals in Pamplona will be recruited.
      The effect of the intensive consumption of different groups of food will be evaluated:
      legumes and fish ( diets in proteins) and vegetable and fruits (rich diets in antioxidants).
      Before and after the intervention, the following items will be analyzed: (1) the diet of the
      subjects, (2) body composition and 3 magnitudes related to biological and development
      parameters, being: (3) lipid and metabolic phenotypic profile; (4) markers of the
      inflammatory status and oxidative stress, and (5) the genomic profile. The dietary programme
      will be implemented both in group workshops addresseded to patients and their family, and in
      individual sessions with the pediatricians and/or registered dieticians. Finally, the
      programme efficacy will be evaluated by the scoreboards integrated in the 5 variables already
      mentioned.
    

Detailed description: 
      A longitudinal intervention study in 44 overweight and obese adolescents (23 females and 21
      males; mean age 11.5 years) for 10 weeks based on a calorie restricted diet (20-40%)
      according to obesity degree.
    

Intervention name(s): Control group; Protein group; Antioxidant group
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Subjects will receive Nutritional education together with weight management counselling for overweight and obesity.
-10 weekly personal interviews with a registered nutritionist for body weight control.; Participants will receive Nutritional education and personalised structured meal plan with a calorie restricted diet (20-40% of the subject's energy expenditure at baseline) according to obesity degree, encouraging high consumption of legumes and fish (protein rich diets).
-10 weekly personal interviews with a registered nutritionist for body weight control.; Participants will receive Nutritional education and personalized structured meal plan with a calorie restricted diet (20-40% of the subject's energy expenditure at baseline) according to obesity degree, encouraging high consumption of fruits and vegetables (antioxidant rich diets).
-10 weekly personal interviews with a registered nutritionist for body weight control.
Intervention MeSH terms: Antioxidants
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: EVASYON; GENOI; antioxidants; legume; fish