Study of Cerebral Activation During Different Rehabilitation Tasks of Lower Limb in Virtual Mirror Therapy in Healthy Subjects
Condition: Healthy
Study type: Observational

Summary: 
      The purpose of this study is to investigate the cerebral activation during visual motor
      simulation in healthy subjects in 3 conditions: observation (OBS), observation and
      imagination (OBS-IM) and observation and realization (OBS-REAL). The investigators goal is to
      compare cerebral activation during the three different tasks using EEG and fNIRS.
    

Detailed description: 
      Mirror therapy is a rehabilitation technique that has been shown to be effective in restoring
      upper limb motor skills in patients with stroke. However, it comes up against certain
      constraints of clinical use such as installation difficulties or the obligation of
      symmetrical bilateral work. These constraints can be limited by the use of so-called 2nd
      generation virtual mirror therapy technologies. It is therefore likely that these new
      technologies will improve the feasibility and effectiveness of mirror therapy in
      rehabilitation.

      The brain mechanisms involved in virtual mirror therapy are not yet fully understood. EEG
      (Electroencephalography) and fNIRS (functional Near Infra Red Spectroscopy) are two
      functional method that allows to study the cerebral cortex changes during different tasks
      (like fMRI).

      These techniques therefore makes it possible to study brain activation under more ecological
      conditions than fMRI and are therefore particularly suitable for exploring rehabilitation
      techniques.

      This research aims to study and compare in healthy subjects, using EEG and fNIRS, the brain
      regions involved in three tasks using a virtual mirror therapy device (IVS4 apparatus ;
      Dessintey, France) implying lower limb control.

      The protocol has 3 conditions :

      observation (OBS), observation and imagination (OBS-IM) and observation and realization
      (OBS-REAL).

      The order of the 3 conditions will then be randomized to avoid potential biases linked to the
      sequence of conditions.

      The EEG recording will used the 32 channels ENOBIO apparatus. The fNIRS will used the Brite
      MKII apparatus
    

Intervention name(s): Observation (OBS); Observation and imagination (OBS-IM); Observation and realization (OBS-REAL)
Intervention type(s): Device; Device; Device
Intervention description(s): Subject is seated in a chair facing IVS4. He places his right lower under the screen. The flexion / extension movement of the ankle at a frequency of 0.5 Hz is then recorded. Then for the "mirror" effect the software reverses the recorded movement, the lower right limb becomes the lower left limb on the screen.
The subject only observe the movement on the screen during the recordings. The subject does not produce any movement.; Subject is seated in a chair facing IVS4. He places his right lower under the screen. The flexion / extension movement of the ankle at a frequency of 0.5 Hz is then recorded. Then for the "mirror" effect the software reverses the recorded movement, the lower right limb becomes the lower left limb on the screen.
The subject observe the movement but also imagine to realized it.; Subject is seated in a chair facing IVS4. He places his right lower under the screen. The flexion / extension movement of the ankle at a frequency of 0.5 Hz is then recorded. Then for the "mirror" effect the software reverses the recorded movement, the lower right limb becomes the lower left limb on the screen.
The subject observe the movement on the screen and realized it
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Right handed healthy subjects aged between 18 and 75 years
      
Keywords: Virtual Mirror therapy; Electroencephalography; Near infrared spectroscopy