bioihbjkbjnl/mcl2 huggingface dataset:
Manual Therapy in Tension-type Headache
Condition: Tension-Type Headache
MeSH terms: Tension-Type Headache; Headache
Study type: Interventional

Summary: 
      Tension-type headache (TTH) causes a significant negative impact on working and daily life
      due to the reduction in work productivity and family and social activities causes. There is
      evidence that manual therapy and exercise reduce nociceptive input from the cervical spine
      and surrounding muscles, the use of manual therapy in TTH management
    

Detailed description: 
      Increased cranio-cervical muscle sensitivity is the most prominent finding in TTH. Also, neck
      pain is markedly more common in individuals with TTH compared with the control population
      (88.4%, and 56.7%, respectively). Therefore, current research on the pathogenesis of TTH
      focuses on the role of musculoskeletal disorders in the cervical spine and the facilitation
      of nociceptive pain processing. It has been suggested that peripheral sensitivity of
      nociceptors in cranio-cervical muscles and other cervical structures, as well as sensitivity
      of nociceptive pain pathways in the central nervous system (CNS) due to long-term nociceptive
      stimuli may play a role in development and chronification of TTH
    

Intervention name(s): manipulation plus exercise; suboccipital inhibition plus exercise; exercise
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): HLVA manipulation was performed for 8 sessions (twice a week for four weeks) using a segment-specific technique for segmental dysfunctions of the upper cervical spine. . By bringing the cervical spine to light flexion and about 15-20º lateral flexion without any rotational motion, the middle finger of the manipulating hand provided deep contact, and an HVLA thrust was applied out of the rotational slack by applying a deep force from the dorsal to the ventral direction; Suboccipital inhibition was performed for 8 sessions (twice a week for four weeks) as a combined muscle and soft tissue inhibition technique. While the patient was in the supine position, the physician sitting at the top end of the table placed the fingers of both hands on the patient's suboccipital region; Patients were asked to exercise at least three days a week during treatment. The exercise program, which lasted 20 to 30 minutes, included cervical range of motion (ROM) exercises to warm-up and cool-down, and then stretching exercises of cervical and upper thoracic spine muscles (trapezius, levator scapula, sternocleidomastoid) and strengthening exercises (cervical isometric contraction and concentric contraction of the deep cervical flexor muscles).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Effects of an Intervention on Improving Midlife Women's Menopause-related Symptoms
Condition: Genitourinary Symptoms
Study type: Interventional

Summary: 
      This study was an experimental study with repeated measures. Study aims were to examine the
      effects of pelvic floor muscles training (PFMT) combined with yoga on improving
      genitourinary/climacteric symptoms, the pelvic floor muscles strength, and health-related
      quality of life (HRQL). Study participants were assigned to the intervention group or
      comparison group. Data analyses were based on the information obtained from 91 midlife women
      with a mean age of 56.6 years. Information related o the pelvic floor muscles strength was
      only obtained from 45 women. Descriptive statistics were used to represent study
      participants' individual characteristics, genitourinary/climacteric symptoms, the pelvic
      floor muscles strength, and HRQL. Paired t tests, independent t tests, and Generalized
      Estimating Equation (GEE) procedures were used to examine the intervention effects.
    

Detailed description: 
      This study was an experimental study with repeated measures. Study aims were to examine the
      effects of PFMT combined with yoga on improving genitourinary/climacteric symptoms, the
      pelvic floor muscles strength, and HRQL. Study participants were randomly assigned to the
      intervention group or comparison group. All study participants received an educational
      section (a discussion section and an abbreviated practice section) and related educational
      materials. The intervention group attended on-site group practice sessions and performed
      individual home-based practice. The comparison group performed individual home-based practice
      only. Data analyses were based on the information obtained from a sample of midlife women
      with a mean age of 56.6 years. Relevant information was mainly collected by a structured
      questionnaire. Information related to the pelvic floor muscles strength was only obtained
      from 45 women in the intervention group by using the FemiScan pelvic floor therapy system.
      Descriptive statistics were used to represent study participants' individual characteristics,
      genitourinary/climacteric symptoms, the pelvic floor muscles strength, and HRQL. Paired t
      tests, independent t tests, and GEE procedures were used to examine the intervention effects.
    

Intervention name(s): Pelvic floor muscles training (PFMT) combined with yoga
Intervention type(s): Behavioral
Intervention description(s): All study participants were instructed to perform PFMT combined with yoga with an expectation of performing a 70-minute practice section 3 days in a week. All study participants received a booklet with menopause-related information, a booklet plus an instructional Digital Video Disc for PFMT and yoga practice.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
To Demonstrate the Relative Bioavailability of Cetirizine Hydrochloride/Pseudoephedrine Hydrochloride 5 mg/120 mg Extended Release (ER) Tablets Under Fed Conditions
Condition: Allergies
MeSH terms: Malnutrition
Study type: Interventional
Phase: Phase 1

Summary: 
      To demonstrate the relative bioavailability of Cetirizine Hydrochloride/Pseudoephedrine
      Hydrochloride 5 mg/120 mg ER tablets under fed conditions.
    


Intervention name(s): Cetirizine HCl/Pseudoephedrine HCl 5 mg/120 mg Tablets (Sandoz, USA); Zyrtec-D 12 Hour 5 mg/120 mg Extended Release Tablets (Pfizer, USA)
Intervention type(s): Drug; Drug
Intervention MeSH terms: Cetirizine; Pseudoephedrine; Ephedrine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Impact of Combined Hormonal Contraceptives on UPA
Condition: Contraception
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this research study is to determine if taking a birth control pill effects how
      well an emergency contraceptive pill called Ulipristal acetate (UPA) works. This type of
      emergency contraceptive is the most effective oral method available. However, this medication
      is an anti-progestin and most regular forms of birth control contain progestin (a female
      hormone). It is unknown if taking the two close together may make the emergency contraceptive
      not work well. The overall goal of this research is to improve the effectiveness of
      contraception for women and to better counsel women.
    

Detailed description: 
      Emergency contraception (EC) provides women with an additional line of defense against
      unintended pregnancy during an act of unprotected intercourse. An antiprogestin, ulipristal
      acetate (UPA; ellaTM), has emerged as one of the most effective oral options. However, there
      is currently a lack of information regarding the practical use of UPA. Basic science studies
      have shown that UPA binds to and prevents progesterone receptor from working, leading to the
      possible concern that hormonal contraceptives, like the birth control pill, would prevent UPA
      from working. Ideally, women should start their regular method of birth control soon after EC
      use but by doing this, they may prevent the UPA EC from working. A woman could just delay
      starting her regular method of birth control but then she is still at risk for pregnancy.

      This proposal has been designed to address this gap in knowledge and will focus on the impact
      of the birth control pill on UPA's ability to delay ovulation (or the release of an egg).
      Subjects will undergo a referent cycle UPA only (Cycle 1, 1 month), followed by a washout
      cycle (Cycle 2, 1 month) and finally UPA with combined oral contraceptives (COCs) dosed 2
      days later (Cycle 3, 1 month treatment cycle). The hypothesis is that starting the birth
      control pill shortly after UPA adversely impacts UPA's ability to delay ovulation.
    

Intervention name(s): Ulipristal Acetate; Levonorgestrel (LNG)/Ethinyl estradiol birth control pill
Intervention type(s): Drug; Drug
Other intervention name(s): UPA; Ella; portia (generic); birth control pills
Intervention MeSH terms: Levonorgestrel; Ethinyl Estradiol; Ulipristal acetate; Contraceptives, Oral; Contraceptives, Oral, Combined; Estradiol
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Emergency contraception; Birth Control Pills
Osteopathic Health Outcomes in Chronic Low Back Pain (OSTEOPATHIC) Trial
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to determine whether osteopathic manipulative treatment (a type
      of spinal manipulative therapy used by osteopathic physicians) and ultrasound physical
      therapy are effective in the treatment of chronic low back pain.
    

Detailed description: 
      The purpose of this study is to determine whether osteopathic manipulative treatment (a type
      of spinal manipulative therapy used by osteopathic physicians) and ultrasound physical
      therapy are effective in the treatment of chronic low back pain. This study uses a 2X2
      factorial design to test the hypotheses.
    

Intervention name(s): A. Active OMT and active UST; B. Sham OMT and active UST; C. Active OMT and sham UST; D. Sham OMT and sham UST
Intervention type(s): Procedure; Procedure; Procedure; Procedure
Intervention description(s): Active osteopathic manipulation (OMT) and active ultrasound physical therapy (UST); Sham osteopathic manipulation (OMT) and active ultrasound physical therapy (UST); Active osteopathic manipulation (OMT) and sham ultrasound physical therapy (UST); Sham osteopathic manipulation (OMT) and sham ultrasound physical therapy (UST)
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Randomized controlled trial; Low back pain; Spinal manipulative therapy; Spinal manipulation; Osteopathic manipulation; Osteopathic medicine; Physical therapy modalities
Restoration vs. Compensation in Neurovisual Rehabilitation of Visual Field Defects
Condition: Hemianopia; Brain Injuries, Traumatic
MeSH terms: Brain Injuries; Brain Injuries, Traumatic; Hemianopsia
Study type: Interventional
Phase: Phase 2

Summary: 
      Visual field defects (VFD) are a frequent effect of cerebral lesions especially after
      posterior cerebral artery stroke. The present study was conducted to compare effects of
      vision restoration training (VRT) and compensation training (Visual Exploration Training,
      VET) on visual field performance.
    


Intervention name(s): Vision Restoration Training (VRT); Vision Exploration Training (VET)
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Evaluate Safety, Pharmacokinetics and Pharmacodynamics of BBT-877 in Healthy Japanese Male
Condition: Healthy Participants
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will collect safety, pharmacokinetic, and pharmacodynamic data in Japanese male
      subjects in order to support development worldwide.
    


Intervention name(s): BBT-877 single dose; Placebo single dose
Intervention type(s): Drug; Drug
Intervention description(s): Oral capsule, single dose.; Oral capsule, single dose.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Comparison of Two Approaches to Weight Loss Follow-Up Study
Condition: Obesity
MeSH terms: Weight Loss
Study type: Interventional
Phase: Phase 4

Summary: 
      This is a follow-up research study to determine if there are any differences in the long-term
      maintenance of two diet groups, the Atkins' diet (low-carbohydrate) or the LEARN program
      (low-fat). The Atkins' diet continues to get a significant amount of popular attention and
      very little scientific evaluation. Due to the small amount of scientific data to support a
      low-carbohydrate diet and given the wide spread use of this type of diet, it is important to
      evaluate the long-term safety and effectiveness of the Atkins' diet.

      We will evaluate whether there are any differences between these two groups 3-years after
      participation in the initial 1-year study period. We will specifically assess weight,
      cholesterol levels, glucose and insulin levels, and eating habits and mood as we did
      originally.
    

Detailed description: 
      ***PLEASE NOTE: Only those who participated in the original study of low carbohydrate and low
      fat diets are eligable for enrollment in this follow-up study***
    

Intervention name(s): Low Carbohydrate Diet
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Weight Loss
Plasma Brain Natriuretic Peptide Levels in Pregnancy
Condition: Cardiomyopathy; Pregnancy
MeSH terms: Cardiomyopathies
Study type: Observational

Summary: 
      To evaluate the maternal blood concentrations of brain natriuretic peptide (BNP) during the
      second and third trimesters of a normal pregnancy. We will attempt to define a normal range
      for pregnancy and any outliers that may serve as markers for abnormal cardiovascular
      physiology.
    

Detailed description: 
      The brain natriuretic peptide (BNP) is a useful marker for volume overload, increased filling
      pressures and stretching of the myocardium. The current literature contains limited and
      unreliable information regarding normal BNP values in pregnancy. After baseline
      echocardiogram to detect individuals with asymptomatic structural defects, the participants
      will submit to 3 blood draws during the second and third trimester and at delivery to
      determine normal pregnancy values.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Healthy pregnant women, 18-40
      
Keywords: brain natriuretic peptide; pregnancy; biomarker
Proof of Confidence Study of CCR2 Antagonist (BMS-741672) in Insulin Resistance
Condition: Type 2 Diabetes
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of the study is to determine whether a CCR2 antagonist (BMS-741672) improves
      glucose homeostasis in drug-naive type 2 diabetic patients
    


Intervention name(s): CCR2 Antagonist; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Tablets, Oral, 50 mg, once daily, 12 weeks; Tablets, Oral, 0mg, once daily, 12 weeks
Other intervention name(s): BMS-741672
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Diabetes; NOS
Evaluation of the Effect of Venous Diameter Measurement by Ultrasonography on Pain and Withdrawal Response
Condition: Pain; Withdrawal
Study type: Observational

Summary: 
      During general anesthesia, intravenous (IV) medications can disrupt the patient's comfort by
      causing a pain sensation or a withdrawal response in the heart. Propofol and rocuronium are
      among the most common causes of this condition.

      In recent years, the use of ultrasonography (USG) in anesthesia has become widespread with
      the rapid advancement of technology. The use of the patient's head is a non invasive method.

      This study is aimed to evaluate whether the size of the venous diameter assessed by
      ultrasonography in our study is an effect on pain and withdrawal response after drug
      injections.
    

Detailed description: 
      The study was conducted in patients who underwent surgical procedures under general
      anesthesia by obtaining consent from the Adnan Menderes University Medical Faculty Ethics
      Board and written consent from the patients and then being admitted to the ASA I-II age group
      18-70 years of age.

      Patients with peripheric vascular disease, vasculitis, rheumatologic disease,
      non-cooperative, under the age of 18 and over 70, ASA III and above, allergic to general
      anesthetic agents and refusing to participate in the study were excluded from the study.
    

Intervention name(s): Pain Score; Withdrawal movement score; hemodynamic response
Intervention type(s): Diagnostic Test; Diagnostic Test; Diagnostic Test
Intervention description(s): Four poin scala 0=No Pain
mild
intermediate
severe; Withdrawal movements
no movement response
movement limited to the wrist
movement limited to the elbow/shoulder,
generalized movement response.; Hemodynamic data were recorded in the patients taken in the operation room. (T0). Hemodynamic values (T1) measured 1 minute after administration of intravenous propofol were recorded. Hemodynamic values (T2) measured 1 minute after administration of intravenous rocuronium were recorded. Hemodynamic values (T3) measured 1 minute after administration of endotracheal intubation were recorded.
Observational model: Case-Crossover
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        The study was conducted on 145 patients aged 17- 70 years of ASA (American Society of
        Anesthesiologists) physical status I- II who were to undergo various elective operations.
        None of the patients was premedicated before the operation. Venous diameter measurements
        were performed in preoperative room via USG.The patients were monitored with three
        derivation electrocardiogram, non- invasive arterial pressure, and pulse oximeter.
      
Keywords: rocuronium; propofol; pain; withdrawal; venous diameter
Economic Evaluation of an Exercise Program After Multidisciplinary Rehabilitation in Patients With Chronic Low Back Pain
Condition: Chronic Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      The purpose of the study is to compare, after functional multidisciplinary rehabilitation for
      chronic low back pain, an exercise program to the routine follow-up which is simply to advice
      patients to exercise regularly at home. The exercise program should help patients stay
      active, which should translate into a better long term quality of life and decreased days off
      work.
    


Intervention name(s): Exercise program; Routine follow-up
Intervention type(s): Other; Other
Intervention description(s): 24 group exercise sessions during 12 weeks; Advice to stay active
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Chronic low back pain; Multidisciplinary rehabilitation; Exercise; Cost-effectiveness
How Our Immune System Can Help Fight Cancer
Condition: Ovarian Cancer
MeSH terms: Ovarian Neoplasms; Carcinoma, Ovarian Epithelial
Study type: Observational

Summary: 
      There is growing evidence that our immune system can help fight cancer. This has stimulated
      interest in the development and application of tumor vaccines for several human solid tumors,
      including epithelial ovarian cancer (EOC). A major obstacle to the development of these
      vaccines is that there are specialty cells called regulatory T cells that prevent the immune
      system from attacking all of our organs. These regulatory T cells also prevent our immune
      system for attacking cancer cells.

      Indoleamine 2,3-dioxygenase (IDO), an enzyme that degrades an essential amino acid tryptophan
      that is necessary for T cells to multiply, however regulatory T cells are less susceptible to
      low levels of tryptophan, and can still multiply. This allows cancer growth and progression.
      This may be explained by genetic polymorphisms (changes) in the IDO gene, which may alter its
      function. Five of these changes in the IDO gene have been described. In this research
      project, we are asking if you would donate a small piece of your tumor and ascites to see if
      we can examine your IDO gene in the tumor cells and see if any of these gene changes are
      present. We hope that this will help us understand how the immune system works in EOC.

      We hypothesize that genetic polymorphisms within the IDO gene alter its enzymatic activity
      and affect the outcome of ovarian cancer patients. These findings have the potential to
      translate into a method for predicting successful immunotherapy.
    


Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with histologically confirmed epithelial ovarian cancer (EOC) who have had
        surgical resection for their disease will be included in this study.
      
Biospecimen description: 
      surgical tissue ascites fluid
    
Keywords: ovarian
Surgical Outcome of Type II Odontoid Fracture, Harms Technique
Condition: Tramatic Odontoid Fracture
MeSH terms: Fractures, Bone
Study type: Interventional

Summary: 
      Cervical trauma is a common cause of disability following spinal cord injury, especially in
      athletic populations. The biomechanics in the atlantoaxial joint carry more than 50% of the
      rotational movement which can be affected in transverse ligament tear associated with
      odontoid fracture type II. Odontoid fracture type II considered an unstable fracture with a
      high rate of non-union in conservative treatment. Limitation of the odontoid screws in some
      cases gives the chance of posterior cervical fixation to have the superior role. Use of
      polyaxial screws in Harms technique gives the best results in maintaining the majority of the
      biomechanics.

      Purpose: our aim in this study to evaluate Harms technique in those patients regarding pain
      improvement and restoration of the motor power and to report the complications.

      Study design: A retrospective case series study. We Used the Frankel grading system to
      evaluate the postoperative neurological state.
    

Detailed description: 
      After approval of Research Ethics Committee, twelve patients with post-traumatic odontoid
      fracture type II were scheduled in our Neurosurgery department at Sohag University Hospital
      for atlantoaxial fusion using polyaxial C1 lateral mass and C2 pedicle screws between January
      2015 and January 2018.
    

Intervention name(s): Harms technique
Intervention type(s): Procedure
Intervention description(s): Atlantoaxial fusion
Other intervention name(s): C1 C2 fusion
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment