bioihbjkbjnl/mcl2 huggingface dataset:
Sonography-guided Steroid Injection for Carpal Tunnel Syndrome
Condition: Carpal Tunnel Syndrome(CTS)
MeSH terms: Carpal Tunnel Syndrome; Syndrome
Study type: Interventional
Phase: Phase 3

Summary: 
      Purpose: To compare the outcome between sonography-guided steroid injection and direct
      steroid injection on carpal tunnel syndrome(CTS).
    

Detailed description: 
      Material and methods: We have enrolled 26 ideopathic carpal tunnel syndrome patients (minimal
      to moderate according to Padua's classification).Thirteen patients were allocated in
      sonography approach group( sonography-guided local wrist injection, SAG) and the 13 patients
      were placed in direct approach group(direct local injection without using sonography, DAG).
      One , 3 and 6 months later after injection, we performed the outcome measures, including
      Boston symptom and functional scale, QuickDASH, nerve conduction study and sonography. If the
      patients receive the second injections, we will follow their treatment outcome by phone
      regularly at 1,3 and 6 months after first injection. If the patients were referred to
      surgery, the failures of local injection were considered and we will stop follow up them.
      After performing all assessment, we will compare the outcomes between the two groups.
    

Intervention name(s): betamethasone
Intervention type(s): Drug
Intervention description(s): Inject betamethasone on the wrist for patient with carpal tunnel syndrome with sonography- guided, directly.
Other intervention name(s): glucocorticoid preparation
Intervention MeSH terms: Betamethasone; Glucocorticoids
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: carpal tunnel syndrome; local steroid injection; sonography; sonography-guided
Safety, Tolerability, and Efficacy of PresbiDrops (CSF-1), a Topical Ophthalmic Drug for Presbyopia
Condition: Presbyopia
MeSH terms: Presbyopia
Study type: Interventional
Phase: Phase 2

Summary: 
      A study to establish safety, tolerability, and efficacy of PresbiDrops (CSF-1) in presbyopic
      subjects.
    


Intervention name(s): PresbiDrops (CSF-1); Placebo
Intervention type(s): Drug; Drug
Intervention description(s): PresbiDrops (CSF-1) is a topical ophthalmic drug.; Placebo drops contains the same ingredients as PresbiDrops except for the active ingredients.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Low Dose Continuous Administration of the Progesterone Receptor Modulator VA2914
Condition: Contraception; Gynecologic Diseases
MeSH terms: Genital Diseases, Female
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of the present study is to evaluate continuous administration of low doses of
      VA2914 for potential contraceptive activity and effects on the menstrual cycle and steroid
      hormone parameters.
    


Intervention name(s): VA2914
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: progesterone receptor modulator
Deformity of the Forefoot in Children With Unilateral Cerebral Palsy
Condition: Forefoot Adductus; Cerebral Palsy
MeSH terms: Paralysis; Cerebral Palsy; Congenital Abnormalities
Study type: Observational

Summary: 
      Midfoot and backfoot deformities are well described in children with Cerebral palsy. However,
      data regarding forefoot deformities in Cerebral palsy remain scarce in a population were foot
      deformities are the most frequent musculo-skeletal deformities.
    

Detailed description: 
      Foot deformities are the most frequent musculo-skeletal deformities in children with Cerebral
      palsy. Pain starts in the foot, especially during gait in Cerebral Palsy Children (GMFCS I
      and II) and induce gait limitations, balance disorders, wounds, aesthetic disorders and
      difficulties to support shoes.

      Metatarsus Adductus is the most common foot deformity in children with or without disorder,
      occuring on 1-2/1000 births. In 4 to 14% of the children, evolution is not favorable at 5
      years. In that case, the diagnostic of Cerebral palsy have to be considered.
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Walking child with unilateral Cerebral Palsy who benefit of a 3D Motion Analysis on the
        motion analysis laboratory in Brest, France, between august 2012 and may 2017.
      
Keywords: Cerebral Palsy; Forefoot Deformity
Peri-implant Marginal Bone and Soft Tissue Conditions Around Single Laser-Lok Implants Placed in Regenerated Extraction Sockets and in Native Bone: A 2-years Results of RCT
Condition: Partially Edentulous Maxilla, Partially Edentulous Mandible
MeSH terms: Mouth, Edentulous
Study type: Observational

Summary: 
      The aim of present study was to compare peri-implant marginal bone loss and soft tissues
      conditions around single Laser-Lok implants placed in alveolar
    

Detailed description: 
      Records of 20 consecutive patients treated with dental implants placed in post-extraction
      sockets augmented with porcine derived bone and 20 consecutive patients with implants placed
      in native bone were reviewed. For each implant, the radio- graphs from the surgical
      appointment were compared to those from the last follow-up visit and evaluated regarding
      changes of marginal bone level over time.
    

Intervention name(s): dental implants
Intervention type(s): Device
Intervention description(s): extraction sockets regenerated with xenograft
Other intervention name(s): porcine derived bone
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        patients with monoedentulism
      
Keywords: regenerated bone, native bone, dental implant
Evaluating the Efficacy of PKU Synergy in Patients Expressing Phenylketonuria or Hyperphenylalaninemia
Condition: Phenylketonurias; Hyperphenylalaninaemia, Type I
MeSH terms: Phenylketonurias
Study type: Interventional

Summary: 
      This study centres around a new one-a-day phenylalanine-free protein substitute for
      phenylketonuria patients. Fifty eligible adults (≥ 16 years) with proven phenylketonuria or
      hyperphenylalaninemia will be recruited and randomly allocated to one of two intervention
      arms (n = 25 per arm). Following a 3-day baseline period, and in addition to routine
      nutritional management, patients will receive either one sachet of the new protein substitute
      daily (intervention) or continue their usual dietary and/or protein substitute regimen
      (maximum of 1 protein substitute per day (equal to 20g protein equivalent) control) for 28
      days.
    

Detailed description: 
      This study centres around a new one-a-day phenylalanine-free protein substitute for
      phenylketonuria patients. In particular, this randomised controlled trial aims to evaluate
      the efficacy (changes relating to nutritional status and metabolic control) of this new
      protein substitute, while also capturing data pertaining to tolerance, compliance, safety and
      acceptability. Designed for poorly compliant adult patients with proven phenylketonuria or
      hyperphenylalaninemia, this new protein substitute is composed of an adapted mixture of other
      essential and non-essential amino acids, carbohydrates, vitamins and selected minerals and
      trace elements and enriched with docosahexaenoic acid (DHA). Fifty eligible adults (≥ 16
      years) will be recruited and randomly allocated to one of two intervention arms (n = 25 per
      arm). Following a 3-day baseline period, and in addition to routine nutritional management,
      patients will receive either one sachet of the new protein substitute daily (intervention) or
      continue their usual dietary and/or protein substitute regimen (maximum of 1 protein
      substitute per day (equal to 20g protein equivalent) control) for 28 days.
    

Intervention name(s): Synergy; Routine
Intervention type(s): Dietary Supplement; Other
Intervention description(s): Small serving (x1 33 g serving daily) of the new phenylalanine-free protein substitute made up with 100mL of water daily (28 days).; Patients will continue their usual dietary and/or protein substitute regimen (28 days).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Phenylketonuria; Hyperphenylalaninaemia; Inherited Metabolic Disorders
A Study of the Intervention Effect of a Hybrid Exercise Program on Frail Elderly
Condition: Frail Elderly Syndrome
Study type: Interventional

Summary: 
      The declining physical condition of frail elderly is becoming an ugent problem. Although the
      exercise intensity of Wu Qin Xi appears to be low, it is highly effective in the older
      individuals. Inspired by the characteristics and functions of Wu Qin Xi, we designed a brand
      new exercise intervention training program among frail older people, which incorporates Wu
      Qin Xi, strength exercises and endurance exercises to improve physical fitness, and even
      reverse the condition of frailty. Furthermore, to improve utility in clinical practice, we
      innovatively employed machine learning simulations to infer the condition of older adults and
      predict their level of frailty after the intervention.
    


Intervention name(s): Wu Qin Xi exercise; Wu Qin Xi, resistance training and endurance training; Resistance training and endurance training
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): The training schedule for Wu Qin Xi consisted of two phases: the first phase lasted for eight weeks, while the second phase lasted for 16 weeks. In the first phase, Wu Qin Xi group was given twice repetitions of the intervention. The second phase consisted of three repetitions of the Wu Qin Xi group. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.; During the first 8 weeks, the training consists of learning and consolidating the movements of the Wu Qin Xi. In the second 16 weeks, participants perform a full set of movement exercises. Each resistance training session contained two lower-body exercises (seated calf raises and hip abduction) and three upper-body exercises (lateral pull downs, biceps curls, and triceps push downs) and two sets for each exercise. Endurance training is performed by continuous walking on an undisturbed indoor track for 15 min. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.; Each resistance training session contained two lower-body exercises (seated calf raises and hip abduction) and three upper-body exercises (lateral pull downs, biceps curls, and triceps push downs) and three sets for each exercise. Endurance training is performed by continuous walking on an undisturbed indoor track for 30 min. Participants warmed up for 20 min prior to the intervention and cooled down for 10 min at the end.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: frailty; exercise intervention
Evaluation Of Cloumella Strut Effect In Tip Rotation
Condition: Nose Deformities, Acquired
MeSH terms: Nose Deformities, Acquired
Study type: Interventional
Phase: Phase 4

Summary: 
      The role of strut in rhinoplasty has been debated for many years and many research has been
      made over this problem but there is no significant data for descision of surgeon, so this
      study was designed to evaluate the effect of columellar strut in tip projection and rotation.
    

Detailed description: 
      In selected case of rhinoplasty use strut randomly and blindly evalute the effect of it in
      tip rotation and projection.
    

Intervention name(s): rhinoplasty
Intervention type(s): Procedure
Intervention description(s): COLUMELLA STRUT PLACEMENT
Other intervention name(s): no other name
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Keywords: RHINOPLASTY ,ESTHETIC SURGERY
Hydrogen Gas for Cancer Rehabilitation
Condition: Adult Solid Tumor
Study type: Interventional

Summary: 
      The aim of this study is the efficacy of hydrogen gas immunotherapy to rehabilitation and
      prognosis of cancer patients.
    

Detailed description: 
      By enrolling patients of multiple kinds of cancer adapted to enrolled criteria, this study
      will document for the first time the short and long term efficacy of hydrogen gas.The
      evaluation indexes include peripheral blood lymphocyte immunoassay, improvement of sleep,
      diet and exercise, progress free survival (PFS) and overall survival (OS).
    

Intervention name(s): oxyhydrogen generator (AMS-H-03); analogue machine
Intervention type(s): Device; Device
Intervention description(s): Rated gas output (L) : 3L/min, concentration of hydrogen and the oxygen was 66.6% and 33.3%, respectively. The patients inhale 3 hours each day through a cannula or mask, and persist for long term; This machine has the same apperance and gas condition
Other intervention name(s): hydrogen generator
Allocation: Randomized
Intervention model: Single Group Assignment
Intervention model description: the patients will inhale hydrogen and oxygen with oxyhydrogen generator
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Solid tumor; Hydrogen gas
Vaccine Therapy in Treating Patients With Stage II or Stage III Colon Cancer That Has Been Removed During Surgery
Condition: Colorectal Cancer
MeSH terms: Colonic Neoplasms
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      RATIONALE: Vaccines made from a patient's white blood cells and tumor cells may make the body
      build an immune response to kill tumor cells. Drugs used in chemotherapy use different ways
      to stop tumor cells from dividing so they stop growing or die. Combining vaccine therapy with
      chemotherapy may kill more tumor cells.

      PURPOSE: Phase I/II trial to study the effectiveness of vaccine therapy combined with
      leucovorin and fluorouracil in treating patients who have undergone surgery to completely
      remove stage II or stage III colon cancer.
    

Detailed description: 
      OBJECTIVES:

        -  Determine safety and immunogenicity of adjuvant autologous tumor cell vaccine in
           patients with completely resected stage II or III adenocarcinoma of the colon.

      OUTLINE: This is a multicenter study. Patients are stratified according to disease stage (II
      vs III).

      Beginning 28-35 days after total surgical resection, patients receive adjuvant autologous
      tumor cell vaccine intradermally once weekly for 3 vaccinations. The first 2 vaccinations
      also contain BCG. Patients with stage II disease receive a fourth vaccination 6 months after
      surgical resection.

      Beginning 10-17 days after the third vaccination, patients with stage III disease receive
      adjuvant leucovorin calcium IV and fluorouracil IV on days 1-5. Chemotherapy continues every
      28-35 days for a total of 6 courses. These patients also receive a fourth vaccination 1 month
      after the completion of chemotherapy.

      Patients are followed at 90 days and 6 months.

      PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.
    

Intervention name(s): BCG vaccine; autologous tumor cell vaccine; fluorouracil; leucovorin calcium; adjuvant therapy
Intervention type(s): Biological; Biological; Drug; Drug; Procedure
Intervention MeSH terms: Leucovorin; Fluorouracil; Vaccines; BCG Vaccine; Calcium; Levoleucovorin
Primary purpose: Treatment
Keywords: stage II colon cancer; stage III colon cancer; adenocarcinoma of the colon
Real-time fMRI Neurofeedback for Mild/Moderate Depression
Condition: Depression Mild; Depression Moderate
MeSH terms: Depression; Depressive Disorder
Study type: Interventional

Summary: 
      The aim of the study is to compare the effects of the self-regulation (neurofeedback) of the
      fMRI signal of the prefrontal cortex in depression to ones of more conventional
      non-pharmacological treatment, primarily, psychotherapy.
    

Detailed description: 
      The study was devoted to the neural, clinical, and psychological effects of the rt-fMRI
      neurofeedback for mild/moderate depression. Recruited unmedicated patients suffering from
      depression were assigned either to the fMRI neurofeedback (8 sessions of the left prefrontal
      cortex activity regulation) or to the active control group, i.e., a double dosage of
      cognitive-behavioral treatment or EEG neurofeedback (preliminary aborted). Depression
      symptoms were measured at baseline, at mid-treatment, and at post-treatment points. Some
      inventories of depression and related traits were also given. In the rt-fMRI group,
      self-regulation learning was also estimated by means of the fMRI signal change.
    

Intervention name(s): Real-time fMRI neurofeedback (rt-fMRI NFB); Сognitive behavioral therapy (CBT); EEG neurofeedback (EEG NFB)
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Real-time fMRI neurofeedback targeting control of the left medial prefrontal cortex. Participants continuously received visual feedback on the level of activity within the 2D region of interest corrected to the whole-slice brain volume activity. Up- and downregulation blocks were switched for better control.; A combination of individual and small-group cognitive behavioral therapy by an experienced medical psychologist and a psychiatrist.; EEG neurofeedback targeting frontal alpha asymmetry index. Participants continuously received visual feedback on their frontal alpha asymmetry index. Up-regulation condition only was utilized.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants were assigned to one of 3 groups: real-time fMRI neurofeedback (rt-fMRI NFB), EEG neurofeedback (aborted), and cognitive behavioral therapy (CBT).
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Neurofeedback; Functional Magnetic Resonance Imaging; Cognitive Behavioral Therapy
Effect of an Investigational Compound on Tolerability of Extended Release Niacin (0524A-023)(COMPLETED)
Condition: Hypercholesteremia; Hyperlipidemia
MeSH terms: Hyperlipidemias; Hyperlipoproteinemias; Hypercholesterolemia
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a 12-week clinical trial in lipid clinic patients for whom niacin therapy is
      appropriate to evaluate the efficacy of MK0524 to improve the tolerability of
      extended-release niacin. There will be 6 scheduled clinic visits and 3 treatment arms.
    


Intervention name(s): MK-0524A; ER Niacin; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: Niacin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Primary Hypercholesteremia; Mixed Hyperlipidemia
A Study to Evaluate the Effect of Camicinal on Gastroparesis Symptoms in Type 1 and 2 Diabetic Subjects With Gastroparesis
Condition: Gastroparesis
MeSH terms: Gastroparesis
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is a randomized, double-blind, placebo controlled trial designed to confirm the
      symptomatic effects of camicinal treatment vs. placebo, on gastroparesis symptoms in type 1
      and 2 diabetic subjects with gastroparesis. The primary purpose of this study is to determine
      if a low-dose of camicinal (25 milligram[mg]) for 12 weeks of repeat administration improves
      gastroparesis symptoms as measured by the Gastrointestinal Cardinal Symptom Index - Daily
      Diary (GCSI-DD) in approximately 120 subjects with type 1 or 2 diabetes mellitus (DM) who
      have documented abnormally slow gastric emptying and have symptoms consistent with
      gastroparesis.

      Subjects will be randomized in a 1:1 ratio to receive either camicinal or placebo. The study
      will consist of a screening/baseline period of up to 35 days, a 12 week treatment period, a
      2-week post-treatment assessment of symptoms and a 14 day (+/- 2 days) post treatment safety
      follow-up visit.
    


Intervention name(s): Placebo; Camicinal
Intervention type(s): Drug; Drug
Intervention description(s): Camicinal matching placebo is available as tablet to be taken orally with 100mL of water in the morning; Camicinal is available as 25 mg tablet to be taken orally with 100mL of water in the morning
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: repeat dose; phase II; GCSI-DD; pharmacodynamics; gastroparesis; type 1 and type 2 diabetes mellitus; camicinal; GSK962040; symptoms; gut motility
Peripheral Histamine 1 Receptor Blockade in IBS: Multicenter Trial
Condition: Irritable Bowel Syndrome (IBS)
MeSH terms: Irritable Bowel Syndrome
Study type: Interventional
Phase: Phase 4

Summary: 
      Purpose:

      To evaluate the efficiency of Irritable Bowel Syndrome (IBS) patients treatment with the
      H1-receptor antagonist ebastine.

      Design:

      Double blind randomized placebo controlled trial. IBS patients receive a 12-weeks treatment
      with ebastine 20mg once daily or placebo (1:1 randomization).
    


Intervention name(s): Ebastine; Placebo
Intervention type(s): Drug; Drug
Intervention MeSH terms: Ebastine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment