bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Bodily Illusion and tDCS on SCI-related Neuropathic Pain
Condition: Neuropathic Pain
MeSH terms: Neuralgia; Illusions
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the effect of a combination of two procedures: (1)
      Bodily Illusion (BI) and (2) Transcranial direct electrical stimulation (tDCS) on neuropathic
      pain.
    


Intervention name(s): Bodily Illusions (BI) Procedure; Transcranial direct electrical stimulation (tDCS); Sham Transcranial Direct Electrical Stimulation (tDCS)
Intervention type(s): Other; Device; Other
Intervention description(s): Each sessions will consists of two types of illusions that are 15 min each, the rubber hand illusion (RHI) and the walking illusion (WI) that involve both arms and legs.; Each sessions will consists of electrical current delivered from a battery-driven, constant current stimulator using saline-soaked surface sponge electrodes. One electrode will be placed on your scalp on the right side and the other electrode over the left eye on your forehead. A weak current will be applied for 30 min at the same time as the BI.; Each session of the Sham tDCS will be applied for 30 min at the same time as the BI.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Comparing the Effectiveness of Three Types of Therapy for the Treatment of Anorexia Nervosa in Adolescents
Condition: Eating Disorders
MeSH terms: Anorexia; Feeding and Eating Disorders; Anorexia Nervosa
Study type: Interventional
Phase: Phase 2

Summary: 
      This study will compare specific family therapy, standard family systems therapy, and
      standard individual psychotherapy to determine which is most effective in treating adolescent
      anorexia nervosa.
    

Detailed description: 
      In adolescents, anorexia nervosa severely affects physical, emotional, and social
      development. Despite the seriousness and prevalence of adolescent anorexia nervosa, few
      studies have focused on the effectiveness of various types of psychotherapy treatment.
      Family-based therapy may be an effective approach to treating adolescent anorexia nervosa.
      This study will compare specific family therapy (FT), standard family systems therapy (FS),
      and standard individual psychotherapy (IT) to determine which is most effective in treating
      adolescent anorexia nervosa. The study also aims to determine potential predictors and
      moderators of outcomes, as well as the cost-benefit ratio of each treatment.

      Participants in this open-label study will be randomly assigned to one of three treatment
      groups. Group 1 will receive FT, Group 2 will receive FS, and Group 3 will receive IT. All
      participants will receive a total of 24 hours of their assigned therapy over a period of 12
      months. Study visits will occur at baseline, immediately post-intervention, and again six
      months and one year post-intervention. Weight change will be assessed, as well as changes in
      concerns about weight and shape. The cost-benefit ratio of the treatments will also be
      evaluated.
    

Intervention name(s): Family therapy (FT); Individual therapy (IT)
Intervention type(s): Behavioral; Behavioral
Intervention description(s): FT is a family-based treatment that will be given for a total of 24 hours over the course of 12 months.; IT is an ego-oriented psychotherapy treatment that will be given for a total of 24 hours over the course of 12 months.
Other intervention name(s): FBT; EOIT or AFT
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Treatment outcomes study; Anorexia; Anorexia nervosa
Fear and Anxiety Level in Dental Patients During the COVID-19 Pandemic
Condition: Fear; Anxiety; COVID-19
MeSH terms: COVID-19; Anxiety Disorders
Study type: Observational

Summary: 
      Psychological support may be needed to help patients in the face of emotional disturbances
      that may be associated with the outbreak and to help them accomplish their fear and anxiety.
      Due to the increasing fear of COVID-19 transmission during the pandemic, patients may develop
      treatment avoidance behavior in dental practices. If the fear and anxiety levels of the
      patients can be determined, it may be easy to offer special approaches to them.
    

Detailed description: 
      Officially, the first COVID-19 case in Turkey was diagnosed on March 10, 2020. To ensure
      social isolation, cities were locked down with residents to stay at home to prevent disease
      transmission. A very large part of the population may experience frustration, stress, and
      irritability while in isolation. Due to the prolonged lockdown and COVID-19 associated fear,
      the COVID-19 pandemic, which threatens people's physical health and lives, is likely to
      trigger a wide variety of psychological problems such as anxiety and depression by increasing
      their stress levels.

      The risk of cross-infection in dentistry has been described as considerably high due to close
      physical contact between dental professionals and patients, and aerosols production during
      routine dental treatments. In this uncertain process, patients remain undecided about
      attending their dental appointments. Their concern is associated with the risk of getting
      infected and transmitting the disease to family members. All these factors may increase the
      mental stress of patients.

      The essential purpose of this study is to evaluate the COVID-19 fear and anxiety level,
      COVID-19 knowledge status, and information sources in dental patients in Turkey during the
      pandemic period.
    

Observational model: Case-Crossover
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        The study population consists of individuals randomly selected from the patients who
        applied to the Faculty of Dentistry.
      
Biospecimen description: 
      Biological samples were not taken from individuals in the study. The study is a survey study.
    
Keywords: COVID-19 Pandemic; COVID-19; fear; anxiety
A Study of Capecitabine (Xeloda®) and Concomitant Radiation Therapy in Children With Newly Diagnosed Brainstem Gliomas
Condition: Brainstem Glioma
MeSH terms: Glioma
Study type: Interventional
Phase: Phase 2

Summary: 
      This study evaluated the effect of capecitabine and concomitant radiation therapy in children
      with newly diagnosed brainstem gliomas.
    

Detailed description: 
      The open-label phase 2 study NO21125 (NCT01118377) evaluated the progression-free survival,
      safety, and pharmacokinetics of capecitabine (Xeloda®) rapidly disintegrating tablets and
      concomitant radiation therapy in children and adolescent patients with newly diagnosed
      brainstem glioma. There were 2 phases to the study: A 9-week radiation phase, followed by a
      2-week rest period, and a 9-week post-radiation phase. In the radiation phase, capecitabine
      650 mg/m^2 was administered orally twice daily for 9 weeks. Concomitantly, patients received
      radiation therapy (180 cGy fractions) 5 days a week for a total target dose of 56 Gy. During
      the 9-week post-radiation phase of the study, capecitabine 1250 mg/m^2 was administered
      orally twice daily for 14 days followed by a 7-day rest period. This cycle of 14 days
      treatment followed by 7 days rest was repeated 2 additional times. The dose could be adjusted
      according to toxicity and body surface area.

      The single-arm phase 1 study NO18517 (NCT00532948) assessed the maximum tolerated dose and
      dose-limiting toxicities of capecitabine (Xeloda®) administered concurrently with radiation
      therapy in children with newly diagnosed diffuse intrinsic brain stem gliomas and high grade
      gliomas. Patients in the phase 1 study NO18517 who were diagnosed with intrinsic brainstem
      glioma and who were treated at the established maximum tolerated dose of capecitabine 650
      mg/m^2/dose twice a day were included in the analyses of the phase 2 study NO21125.

      The efficacy and safety results of study NO21125 are reported below.
    

Intervention name(s): Capecitabine; Radiation therapy
Intervention type(s): Drug; Radiation
Intervention description(s): Capecitabine was supplied as film-coated tablets.; Local irradiation using conformal, volume-based delivery techniques. The nominal energy of the X-rays was ≥ 4 MV.
Other intervention name(s): Xeloda
Intervention MeSH terms: Capecitabine
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Comparison of Antisecretory Effect of a Single Dose of Rabeprazole 20 mg and Omeprazole 20 mg in Obese Subjects
Condition: Gastroesophageal Reflux
MeSH terms: Gastroesophageal Reflux
Study type: Interventional
Phase: Phase 2

Summary: 
      This study aims to determine, in obese subjects, the antisecretory effect of a single dose of
      placebo, rabeprazole 20 mg and omeprazole 20 mg using 24h gastric pH monitoring, in a
      prospective, monocentre, randomized manner. Monitorings are separated between 6 and10 days.
      The main outcome criteria of analysis is the percentage of time with gastric pH above 3
      during 24hours.
    


Intervention name(s): Omeprazole; Rabeprazole; Lactose
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: Omeprazole; Rabeprazole
Nicotinic Enhancement of Cognitive Remediation Training in Schizophrenia
Condition: Schizophrenia; Schizoaffective Disorder
MeSH terms: Schizophrenia; Psychotic Disorders
Study type: Interventional

Summary: 
      Schizophrenia is marked by problems in attention, memory and problem solving. These deficits
      predict long-term functional outcome such as the ability to live independently and maintain
      employment, but they are not ameliorated by currently available medications. Cognitive
      training improves these functions to some degree, but this approach is time- and
      resource-intensive. The current project aims at enhancing and accelerating the benefits that
      people with schizophrenia derive from cognitive training by administering nicotine during
      some of the training sessions. This would provide the proof of principle for a type of
      treatment intervention to improve cognitive symptoms of schizophrenia.

      The current project aims at determining whether the intermittent presence of nicotine during
      cognitive training exercises in people with schizophrenia will shorten the training period
      necessary to induce significant and clinically relevant improvement and enhance the
      improvement seen after a training period of specified length.

      Hypothesis 1a: Nicotine administration during training will increase the size of all measured
      effects of the training intervention, and will accelerate the time course of performance
      enhancement on the MCCB and training exercise progression parameters.

      Hypothesis 1b: The larger training effects in the Nicotine Group will persist beyond the end
      of the intervention.

      Hypothesis 2a: Within-session progress on the training exercises will be larger in the
      presence of nicotine than in the presence of placebo.

      Hypothesis 2b: These acute nicotine-induced performance elevations will persist beyond the
      presence of nicotine through subsequent non-drug training sessions, giving evidence of an
      acute facilitation of learning processes.
    


Intervention name(s): Cognitive remediation training; Nicotine polacrilex lozenge
Intervention type(s): Behavioral; Drug
Intervention description(s): Of interest are the effects of nicotine on cognitive remediation training benefits.
Other intervention name(s): Posit Science cognitive remediation training; Nicorette polacrilex lozenges, GlaxoSmithKline, 2 mg and 4 mg
Intervention MeSH terms: Nicotine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: schizophrenia; cognition; cognitive remediation; nicotine
Treating Verbal Memory Deficits Following Chemotherapy for Breast Cancer
Condition: Breast Cancer Treatment; Cognitive Deficits
MeSH terms: Breast Neoplasms; Memory Disorders; Cognition Disorders; Cognitive Dysfunction
Study type: Interventional

Summary: 
      The primary purpose of this study is to test the effects of a targeted, computerized
      cognitive training program on verbal memory in older women who have undergone chemotherapy
      treatment for early-stage breast cancer. As measured by neuropsychological assessment, this
      treatment will result in improved verbal memory. Secondarily, processing speed and naming
      abilities are expected to improve. Enhanced self-perception of cognitive ability is also
      expected.
    


Intervention name(s): Computerized cognitive treatment
Intervention type(s): Behavioral
Intervention description(s): Participants will engage in auditory and verbal memory exercises intended to improve verbal memory functioning. The exercises are: Elephant Memory, Words where are you?, Split words, Bird Songs, Sound check, and You've got voicemail. Participants will complete the exercises 1 hour per day, 6 days per week, for 6 weeks. The program automatically adjusts difficulty level according to individual performance. The program captures and reports all relevant data to the primary investigator, including accuracy and reaction time (speed), which will be used to measure progress.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Breast Cancer; Chemotherapy; Verbal Memory; Processing Speed
A Trial Evaluating the Effects of Zoledronic Acid 5 mg Infusion on Bone Mineral Density (BMD) in Postmenopausal Osteoporosis (PMO) Patients Between the Ages of 50 and 65 Years
Condition: Postmenopausal Osteoporosis
MeSH terms: Osteoporosis; Osteoporosis, Postmenopausal
Study type: Interventional
Phase: Phase 3

Summary: 
      This study will evaluate the effects of zoledronic acid 5 mg infusion on BMD and biochemical
      markers of bone in post-menopausal osteoporotic patients aged between 50-65.
    


Intervention name(s): Zoledronic acid
Intervention type(s): Drug
Intervention MeSH terms: Zoledronic Acid
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Osteoporosis; Bone Mineral Density; Biomarkers
Consistency of 3 Consecutive Lots of a Novel HBV Vaccine With Single-blind Safety Evaluation Using Engerix™-B as Control
Condition: Hepatitis B
MeSH terms: Hepatitis B; Hepatitis
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of the present study is to evaluate the immunogenicity and safety of three
      consecutive production lots of the novel adjuvanted HBV vaccine. The safety of the candidate
      vaccine will be assessed using Engerix™-B as control.
    

Detailed description: 
      Double-blind for the identity of the consistency lots, single-blind for the control
      group/study vaccine identity.

      At the time of conduct of this study, the sponsor GlaxoSmithKline was known by its former
      name SmithKline Beecham
    

Intervention name(s): HBV-MPL vaccine 208129; Engerix™-B
Intervention type(s): Biological; Biological
Intervention description(s): 3 consecutive lots; 3-dose intramuscular injection; 3-dose intramuscular injection
Other intervention name(s): HBV-MPL vaccine 208129
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Adjuvanted hepatitis B vaccine; Hepatitis B; Recombinant hepatitis B vaccine
Trial of Olanzapine in Patients With Manic or Mixed Episode of Bipolar I Disorder
Condition: Bipolar Disorder
MeSH terms: Bipolar Disorder
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to confirm the efficacy of olanzapine in the treatment of manic
      or mixed symptoms associated with bipolar I disorder.
    


Intervention name(s): olanzapine; haloperidol; placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 5-20 mg, oral, once daily (evening), for 6 weeks; 2.5-10 mg, oral, twice daily (morning and evening), for 6 weeks.; placebo, oral tablets, twice daily (morning and evening), for 3 weeks
Other intervention name(s): LY170053; Zyprexa
Intervention MeSH terms: Haloperidol; Olanzapine; Haloperidol decanoate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Manic or mixed episode associated with bipolar I disorder
Evaluation of Chest Physiotherapy for Acute Bronchiolitis in Toddlers (BRONKINOU)
Condition: Viral Bronchiolitis
MeSH terms: Bronchiolitis; Bronchiolitis, Viral
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether chest physiotherapy with forced expiratory
      technique reduces delay of healing in acute bronchiolitis of children between 15 days and 24
      months of age.
    

Detailed description: 
      Bronchiolitis is the most common lower respiratory infection in infants, and the respiratory
      condition leading to the majority of hospital admissions in young children. It is also
      probably the most common serious illness of childhood lacking evidence-based treatment.
      Evidence against the effectiveness of chest physiotherapy with vibration and postural
      drainage techniques has been described but forced expiratory technique, as described in
      France, has never been evaluated.

      The investigators hypothesised that forced expiratory technique was able to reduce the
      duration of respiratory distress.

      Comparison(s): The investigators compare physiotherapy with forced expiratory techniques to
      simple aspiration of naso-pharyngeal secretions.
    

Intervention name(s): Chest Physiotherapy with Forced Expiratory Technique; Nasopharyngeal Aspiration
Intervention type(s): Procedure; Procedure
Intervention description(s): Chest Physiotherapy with Forced Expiratory Technique; Nasopharyngeal Aspiration
Other intervention name(s): A. Chest Physiotherapy with Forced Expiratory Technique
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Acute Bronchiolitis; Chest Physiotherapy; Forced Expiratory Techniques; Double Blind Trial; Children; Pediatric; RESPIRATORY SYNCYTIAL VIRUS
Intelligent Pain Management System for Assessing Pain in Cancer Patients
Condition: Pain; Neoplasms
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether the Intelligent Pain Management System
      (IPMS) could make recording and interfering pain timely among cancer patients with pain. The
      system's usability, feasibility, compliance, and satisfaction will also be assessed.
    

Detailed description: 
      Research indicate that over one-third of cancer patients experienced cancer pain, which is
      known as a major reason leading to lower quality of life of the patients.In this present
      study, the investigators aim to design, develop, and test the feasibility of a low cost,
      conveniently implemented mobile application to facilitate real-time pain recording and timely
      intervention among Chinese cancer patients with pain. This system evaluate real-time pain and
      Karnofsky Performance Status（KPS）scores for quality of life, and to generate an action plan
      to visit the physician or to adjust pain medication dosage when the pain threshold is
      reached. The investigators study is to test this system's effectiveness.
    

Intervention name(s): Intelligent Pain Management System
Intervention type(s): Device
Intervention description(s): A mobile phone application which can record the pain the cancer patients have and can deliver these records to doctors in order that doctors give patients prescriptions promptly.
Other intervention name(s): IPMS
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: cancer pain; mobile applications
Sequential Segmental Treatment of Emphysema With Upper Lobe Predominance (STEP-UP) Study
Condition: Emphysema
MeSH terms: Pulmonary Emphysema; Emphysema
Study type: Interventional

Summary: 
      This study is designed to demonstrate safety and efficacy in patients with severe upper lobe
      predominant emphysema. For validity of the study, the results will be compared to patients
      that receive optimal medical therapy.
    


Intervention name(s): InterVapor® treatment plus Optimal Medical Therapy; Optimal Medical Therapy
Intervention type(s): Device; Other
Intervention description(s): Patients will be treated with the InterVapor System in 1 to 2 segments in the upper lobes of each lung (2 to 3 segments total). Patients will also receive Optimal Medical Therapy. Guidelines for prescribing medical treatment for emphysema are published by the American Thoracic Society (ATS) and the National Heart Lung and Blood Institute/World Health Organization (NHLBI/WHO GOLD workshop summary).; Patients will receive Optimal Medical Therapy. Guidelines for prescribing medical treatment for emphysema are published by the American Thoracic Society (ATS) and the National Heart Lung and Blood Institute/World Health Organization (NHLBI/WHO GOLD workshop summary).
Other intervention name(s): InterVapor or BTVA
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: emphysema; InterVapor; treatments; pulmonary rehabilitation; lung volume reduction; endoscopic lung volume reduction