bioihbjkbjnl/mcl2 huggingface dataset:
External Oblique Intercostal Plane Block Versus Subcostal Transversus Abdominis Plane Block in Supra-umbilical Surgical Incisions
Condition: Pain, Postoperative
MeSH terms: Pain, Postoperative; Surgical Wound
Study type: Interventional

Summary: 
      Various newer techniques have been proposed to enhance analgesia in upper abdominal region.
      The subcostal transverse abdominis plane (SCTAP) block is the deposition of local anesthetic
      in the transverse abdominis plane inferior and parallel to the costal margin. There is a
      growing consensus that the SCTAP block provides better analgesia for upper abdominal
      incisions than the traditional transverse abdominis plane block.

      The External oblique intercostal plane (EOIP) block is a novel technique reported by Hamilton
      et al. performed EOPB by administering LA superior or deep of the external oblique muscle
      from the sixth intercostal space leading to the blockage of thoracoabdominal nerves at
      T6-T10. It has several attractive aspects such as easy sono-anatomy ribs one strip of muscle
      so easy to demonstrate even in obese patients, there is a bony backstop, easy expandable
      fascial plane that can accommodate a catheter and it is shallow block with no big vessels
      nearby.
    


Intervention name(s): external oblique intercostal plain block (EOIP); subcostal transversus abdominis plane block (SCTAP); control group
Intervention type(s): Procedure; Procedure; Other
Intervention description(s): A high-frequency linear ultrasound probe will be placed in a longitudinal parasagittal orientation at the sixth intercostal space in the anterior midaxillary line. A 21G 10 cm needle will be inserted using an in plane approach. The tip of the needle will be placed into the fascial plane on the deep aspect of the external oblique muscle. A volume of 20 mL of LA mixture (10 mL of bupivacaine 0.5%, 5 mL of lidocaine 2% and 5 mL of normal saline to make a mixture totaling 20 ml.) will be injected.; The US probe will be placed immediately below the costal margin on oblique plane toward the lateral close to midline to identify the rectus abdominis muscle. The transversus abdominis muscle will be identified lying posterior to the rectus muscle. An 8cm 22-gauge block needle will be inserted using an in- plane approach. transversus abdominis plane will be accessed by placing the needle adjacent to costal margin but medial to linea semilunaris. The needle will be advanced slowly in-plane to promote hydrodissection along the oblique subcostal line. A volume of 20 mL of LA mixture (10 mL of bupivacaine 0.5%, 5 mL of lidocaine 2% and 5 mL of normal saline to make a mixture totaling 20 ml.) will be injected.; No LA injection
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Investigation of Immediate, Short and Long Term Effects of Mulligan Mobilization With Movement Techniques in Nonspesific Chronic Low Back Pain
Condition: Chronic Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      Introduction: Although the effectiveness of many mobilization methods in chronic low back
      pain (CLBP) was shown, these effects were not monitored in the long term. The aim of this
      study was to identify the immediate, short and long-term effects of mulligan mobilization
      with movement (MWM) in terms of pain, range of motion (ROM), flexibility, endurance,
      functionality and disabilities in patients with CLBP. Methods: The study was designed in
      randomized-placebo controlled with 36 people randomly distributed into 2 groups. Sustained
      natural apophyseal glide (SNAG) was applied to the lumbar region, straight leg raise (SLR)
      with traction to the hip, and internal rotational mobilization techniques and home exercise
      program were applied in Group 1 (n=19); and the same techniques were applied as sham
      mobilization in Group 2 (n=17). The evaluations were made as post-intervention for immediate
      effect, and were also made at the 5th week, 3rd month, and 6th months for short and long-term
      effect. Evaluation was also made for pain in 12th month.
    


Intervention name(s): Mulligan mobilization with movement
Intervention type(s): Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Acute Effects of Ginger Extract Consumption on Risk Markers of Cardiovascular Disease
Condition: Cardiovascular Disease
MeSH terms: Cardiovascular Diseases
Study type: Interventional

Summary: 
      The primary aim of the study was to investigate the acute effect of ginger drink consumption
      on the risk markers of cardiovascular disease.
    

Detailed description: 
      A randomized, single-blind human intervention study involving 22 healthy male volunteers was
      designed to investigate the acute effects of ginger drink consumption on risk markers of
      cardiovascular disease (CVD). The primary outcome measure is reduction in blood pressure
      while the secondary outcome measures are improvement in flow mediated dilatation (FMD) and
      changes in plasma biochemical profile parameters related to CVD. Participants were given 300
      ml of ginger extract or water (placebo) with breakfast, followed by a lunch at 2 hours on two
      visits separated by 2 weeks. Blood and urine samples were collected at regular intervals as
      well as blood pressure measurement done during the two visits. Vascular function was measured
      by flow mediated dilatation (FMD) and pulse wave velocity (PWV) at baseline, 2 and 4 hours
      after the the consumption of the study drink and placebo. The blood and urine samples were
      analysed for changes in lipid profile and other markers of CVD.
    

Intervention name(s): Ginger drink; Placebo: Super pure water
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 300 ml ginger drink; Placebo: Super pure water
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: Ginger; blood pressure; flow mediated dilatation
The Cardiopulmonary Effects and Diaphragm Function of Complete Inspiratory Muscle Training in Patients With Upper Abdominal Surgery
Condition: Inspiratory Muscle Training; Postoperative Pulmonary Complications; Respiratory Muscle Function; Abdominal Surgery
MeSH terms: Respiratory Aspiration
Study type: Interventional

Summary: 
      Upper abdominal surgical treatment may have reduced respiratory muscle function and
      mucociliary clearance, which might be a consequence of postoperative pulmonary complications
      (PPCs). The threshold inspiratory muscle training (IMT) may serve as an effective modality to
      improve respiratory muscle strength and endurance in patients. However, whether this training
      could help patients with upper abdominal surgery remain to be determined.
    


Intervention name(s): Inspiratory muscle training; Regulated care and education
Intervention type(s): Behavioral; Behavioral
Intervention description(s): The initial training intensity of the preoperative threshold IMT trainer (DofinTM, Breathing Strength Builder, Taiwan) was moderate to high intensity (≥50% of MIP), which was according to the patient's baseline level and increased by 5-10% per week. The frequency is 25-30 minutes each time, twice a day and five days per week for at least two weeks. The participants would receive at least 10 times training sessions before surgery; Regulated care and education will be applied
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The study population will be randomized and separated in two groups, Intervention and Usual care group.
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: inspiratory muscle training; postoperative pulmonary complications; respiratory muscle function; abdominal surgery
GooDMoMS: A Multimodel Pregnancy and Postpartum Intervention for Gestational Diabetics
Condition: Gestational Diabetes Mellitus; Pregnancy
MeSH terms: Diabetes, Gestational
Study type: Interventional

Summary: 
      This study includes a behavioral educational intervention that focuses on healthy eating and
      physical activity during pregnancy and the postpartum among women newly diagnosed with
      gestational diabetes mellitus (GDM).
    

Detailed description: 
      This is a pilot trial in which 30 women newly diagnosed with gestational diabetes are
      randomized to either one of two groups: 1) active internet intervention or 2) self-directed
      educational intervention. The primary pregnancy outcome is change in A1C. The primary
      postpartum outcome is weight.
    

Intervention name(s): lifestyle counseling
Intervention type(s): Behavioral
Intervention description(s): Participants receive lifestyle counseling on healthy eating and physical activity through an internet-based program or self-directed educational program.
Other intervention name(s): healthy lifestyle; glucose control
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: gestational diabetes
Body Mass Index and Post-dural Puncture Headache
Condition: This Study Investigated the Influence of Body Mass Index (BMI) on PDPH in Elective Caesarean Section Patients in Whom 27G Spinal Needles Were Used
MeSH terms: Post-Dural Puncture Headache; Headache
Study type: Interventional

Summary: 
      Post-dural puncture headache (PDPH) is seen more frequently in pregnant women due to stress,
      dehydration, intra-abdominal pressure, and insufficient fluid replacement after delivery.
      Obesity protects against PDPH in pregnant women; increased intra-abdominal fat tissue reduced
      cerebrospinal fluid leakage by increasing the pressure in the epidural space. Therefore, this
      study investigated the influence of body mass index (BMI) on PDPH in elective caesarean
      section patients in whom 27G spinal needles were used.
    

Detailed description: 
      The study included 420 women with American Society of Anesthesiology physical status I-II who
      underwent elective caesarean section under spinal anesthesia. The patients with a BMI less
      than 30 were accepted as normal weight (Group I) and those with a BMI above 30 were accepted
      as obese (Group II). Dural puncture performed with a 27G Quincke spinal needle at the L3-4 or
      L4-5 intervertebral space and given 12.5 mg hyperbaric bupivacaine intrathecally. The
      patients were questioned regarding headache and low back pain 6, 12, 24, and 48 hours after
      the procedure, and by phone calls on days 3 and 7.
    

Intervention name(s): spinal anesthesia
Intervention type(s): Procedure
Intervention description(s): 12.5 mg hyperbaric bupivacaine intrathecally following a successful dural puncture performed with a 27G Quincke spinal needle at the L3-4 or L4-5 intervertebral space in the sitting position
Other intervention name(s): bupivacaine
Intervention MeSH terms: Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Diagnostic
Study of Post-Exposure Ingavirin® Prophylaxis of Influenza and Acute Respiratory Viral Infections
Condition: Influenza, Human; Acute Respiratory Infection; Common Cold; Flu; Viral Infection
MeSH terms: Infections; Communicable Diseases; Influenza, Human; Respiratory Tract Infections; Virus Diseases; Common Cold
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of the study was to evaluate efficacy of prophylactic Ingavirin intake by people
      having contact with sick people infected with influenza and other acute respiratory viral
      infections
    

Detailed description: 
      The study includes 7 days of treatment period and 30 days of follow-up, 37 days total.

      The participant was receiving Ingavirin or placebo for 7 days. Then during 30 days the
      participant was under supervision.

      Visits were performed at days 2-7 (every day) since inclusion and then every 5 days during
      follow-up period.

      Wherever during the study the participant developed symptoms of flu or other acute
      respiratory viral infection, the participant was taken for medical care to observe his
      condition, symptoms dynamics, lab tests, including laboratory verification of viral origin of
      the disease. Medical care was established for 10±2 days since symptoms. Everyday for 3 days
      and additional visits for 5±1 and 10±2 days of the disease.

      The patient had the required symptomatic treatment, additionally the patient could be
      institutionalised if necessary.

      Wherever the participant developed symptoms during treatment period, the patient was taken
      investigational drug on schedule.
    

Intervention name(s): Ingavirin (Imidazolyl Ethanamide Pentandioic Acid); Placebo oral capsule
Intervention type(s): Drug; Drug
Intervention description(s): Broad-spectrum antiviral agent; Placebo capsule to match Ingavirin capsule
Intervention MeSH terms: Pentanedioic acid imidazolyl ethanamide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Prevention
Keywords: Profilaxis; Ingavirin
Effects of Magnetic Tape on the Autonomic Nervous System
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      The effect of magnetic tape on pain and autonomic nervous system in subject with lower back
      pain.
    

Detailed description: 
      The effects of magnetic nanoparticles in tape applied in the lumbar spine on the autonomic
      nervous system measured with fully automated pupillometry and on pain in the spine measured
      with posterior to anterior pressure on the spinous process and the skin pinch test
      paravertebrally
    

Intervention name(s): Magnetic tape; Placebo tape
Intervention type(s): Other; Other
Intervention description(s): Tape with magnetic nanoparticles applied to the skin; Tape without nano particles applied to the skin
Allocation: Randomized
Intervention model: Single Group Assignment
Intervention model description: Single group design with random allocation of intervention placebo versus treatment tape. Next day other intervention was used
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: Magnetic tape; magnetic nano particles; Pupillometry; Autonomic nervous system; lower back pain; PA test; Skin pinch test
Effects of Transcutaneous Electrical Nerve Stimulation on Cortical Excitability in the Primary Motor Cortex in Healthy Adults
Condition: Transcutaneous Electrical Nerve Stimulation
Study type: Interventional

Summary: 
      Recently, non-invasive brain stimulation has become a powerful tool in both basic research
      and clinical application. Among several non-invasive brain stimulation techniques,
      transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS)
      have received the most attention. About DC stimulation, the change of polarity could modulate
      the spontaneous neuronal activity and make effect on decision making, language, memory,
      sensory perception, and pain. In spite of that the concept of transcranial alternating
      current stimulation (tACS) is not novel, AC is relatively safe compared to DC, and researches
      have revealed that AC might potentially have the effect on the cortical excitability.
      However, there are still many areas about AC stimulation which remain unknown, such as
      mechanism, application, and potential influence on cortical excitability.
    


Intervention name(s): transcutaneous electrical nerve stimulation, TENS
Intervention type(s): Device
Intervention description(s): Then participants will receive stimulation for 20 minutes.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: transcutaneous electrical nerve stimulation; transcranial magnetic stimulation
Effects of Dexmedetomidine on Respiratory Mechanics and Oxygenation During One Lung Ventilation With Chronic Obstructive Lung Disease
Condition: COPD, One Lung Ventilation
Study type: Interventional

Summary: 
      COPD is often associated with the airflow limitation and the pulmonary hyperinflation. During
      the one-lung ventilation (OLV), COPD patients' physiologic dead space increases and
      hypercapnia may develop. In addition, an alveolar overdistention by the pulmonary
      hyperinflation would divert pulmonary blood flow and impair arterial oxygenation.
      Dexmedetomidine has both vasoconstricting and vasodilatatory effects on a peripheral
      vasculature and a smooth muscle but its effects on bronchial smooth muscle is unknown. The
      investigators will evaluate the effects of dexmedetomidine (bolus of 1.0 μg kg-1 over 10 min
      followed by a continuous infusion at 0.5 μg kg-1 h-1 infusion during one-lung ventilation) as
      bronchodilator in COPD patients when administered during surgery with the one lung
      ventilation. If result successfully shows the effect of dexmedetomidine as a predominantly a
      vasodilator on bronchial tree, the investigators study can support the dexmedetomidine as a
      vasodilator for pulmonary vessels and bronchial smooth muscle and as an excellent adjunct to
      anesthetic agents in COPD patients during the OLV.
    


Intervention name(s): saline infusion; dexmedetomidine infusion
Intervention type(s): Drug; Drug
Intervention description(s): saline infusion, bolus of 1.0 μg kg-1 over 10 min followed by a continuous infusion at 0.5 μg kg-1 h-1 infusion during one-lung ventilation, intravenous; dexmedetomidine, bolus of 1.0 μg kg-1 over 10 min followed by a continuous infusion at 0.5 μg kg-1 h-1 infusion during one-lung ventilation, intravenous
Intervention MeSH terms: Dexmedetomidine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
The Dermisgraft Epithelialization and Late Scar Healing
Condition: Burns
Study type: Interventional

Summary: 
      Study Synopsis

      Title; The dermis graft: epithelialization and late scar evaluation A Clinical Prospective
      multicenter trial

      Objectives; The objective of this study is to compare a dermal graft with a conventional
      split thickness skin graft regarding healing quality and scarring.

      Design; the study is a prospective, controlled clinical multicenter trial.

      Study population; Atleast 20 burn patients (18-80 years) with a full thickness burn that
      requires permanent skin cover.

      Time plan; Enrollment will continue until atleast 20 patients have been included and
      completed the study.
    

Detailed description: 
      Background: Donor site morbidity is a major concern such as wound healing disturbances,
      hypertrophic scarring and hypo-/hyperpigmentation. The dermal graft technique is an
      alternative to the standard split-thickness skin graft (STSG) technique to minimize donor
      site morbidity. Immediate cover of the donor site after harvest leaving a non-exposed wound
      is a big advantage. The aim of the study was to compare the functional and aesthetic outcome
      between two treatment methods (dermal graft with STSG).

      Methods: From February 2017 to December 2020, 21 patients received a dermis graft and a
      regular split-thickness skin graft in a prospective randomized study design. The recipient
      and the donor site were compared separately regarding healing time, scarring and patient
      subjective satisfaction. All sites (both donor and recipient) were analyzed histologically
      regarding remodeling and scar formation.
    

Intervention name(s): Skin transplantation to heal burn injuries
Intervention type(s): Procedure
Intervention description(s): The study compare two different treatment modalities, STSG (split-thickness skin graft) versus dermis graft after excision of devitalized/necrotic tissue.
A dermatome will be used for graft harvest.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Evaluation of Platelet Function After Statin Loading Dose in Patients Before Percutaneous Coronary Intervention
Condition: Platelet Dysfunction
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate the effect of a loading dose of two different
      statins on platelet reactivity (atorvastatin, metabolized by CYP3A4, and rosuvastatin, which
      is rather independent of this enzyme)in patients at least 5 days in therapy with aspirin and
      clopidogrel (with or without an undergoing treatment with statins) undergoing PCI for
      coronary disease with chronic stable angina and/or evidence of inducible myocardial ischemia.
    

Detailed description: 
      An initial assessment of platelet reactivity in response to the TRAP (thrombin receptor
      agonist), ADP and arachidonic acid (respectively, indicative of the response to clopidogrel
      and aspirin) will be performed with impedance aggregometry (Multiplate® analyzer system).
      Patients with a increased residual platelet reactivity to ADP test (AUC > 47) will receive a
      different antiplatelet therapy and will then be excluded from the study, the other will be
      randomized to 3 groups of treatment.
    

Intervention name(s): Atorvastatin; Rosuvastatin; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 80 mg; 40 mg; no statin loading dose
Other intervention name(s): TORVAST; TOTALIP; CRESTOR; NO STATIN DRUGS
Intervention MeSH terms: Atorvastatin; Rosuvastatin Calcium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Platelet; Atorvastatin; Rosuvastatin; Multiplate; reactivity
Efficacy and Safety of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID)
Condition: Agammaglobulinemia; IgG Deficiency; Common Variable Immunodeficiency
MeSH terms: Agammaglobulinemia; IgG Deficiency; Primary Immunodeficiency Diseases; Immunologic Deficiency Syndromes; Common Variable Immunodeficiency
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to demonstrate the effect of IgPro10 on the prevention of
      serious bacterial infections in patients with primary immunodeficiency.

      As secondary endpoints the rate of overall infections, the tolerability and safety of IgPro10
      are studied.

      A part of the patients are participating in a pharmacokinetic substudy.
    


Intervention name(s): Immunoglobulins Intravenous (Human)
Intervention type(s): Drug
Intervention MeSH terms: Immunoglobulins; Immunoglobulins, Intravenous; Antibodies
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Immunoglobulin Intravenous; Agammaglobulinemia; Hypogammaglobulinemia; Common variable immunodeficiency; Immunoglobulin G; Children