Normative State and Variation in Growth, Hematology, Hydration, Oxidation, Infection, Inflammation, Guatemalan Children
Condition: Healthy
MeSH terms: Infections; Inflammation
Study type: Observational

Summary: 
      This study will provide the researchers with an opportunity for the investigation of the
      biomarkers and different human biology component variable interactions in children;
      information that can generate new correlations between markers not known at the moment.

      Regarding their analysis, variation could have multiple connotations. A categorical that
      refers to a specific state, established with a diagnostic standard. And a numerical,
      referring to a range or the absolute value limits in a continuous spectrum; this research
      will allow us to express variability in the distance amplitude of the obtained values level,
      as well as classifications or categories previously established in the possible cases.

      OBJECTIVES PRINCIPAL OBJECTIVE

      To estimate the inter and intra-individual variety in a selected series or biological
      variables determinant of growth, body composition, infection, oxidation, inflammation and
      hydration, in preschool children sharing the same institutional-based diet.

      SPECIFIC OBJECTIVES

        -  To determine the inter and intra-individual variation of growth in preschool children,
           with a similar diet, who attend Secretariat of Beneficial Works of the First Lady system
           daycare centers and to compare between semi-urban and rural.

        -  To describe the inter-individual variation of the red blood cells circulating mass in
           preschool children, with a similar diet, who attend day care centers and to compare
           between semi-urban and rural.

        -  To determine the inter-individual variation of systemic and intraintestinal oxidation in
           preschool children, with a similar diet, who attend daycare centers and to compare
           between semi-urban and rural.

        -  To describe the inter-individual variation of systemic and intraintestinal inflammation
           in preschool children, with a similar diet, who attend daycare centers and to compare
           between semi-urban and rural.

        -  To determine the inter and/or intra-individual variation of urinary tract infection and
           gastrointestinal parasite infestation in preschool children, with a similar diet, who
           attend daycare centers and to compare between semi-urban and rural.

        -  To describe the inter and intra-individual variation of the hydration status in
           preschool children, with a similar diet, who attend daycare centers and to compare
           between semi-urban and rural.

        -  To explore intra-individual associations in variables of the same research component or
           different component variables.
    

Detailed description: 
      Please note protocol is also available in Spanish.
    

Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Apparently healthy children who attend 3 daycare centers (one semi-urban, one
        urban-marginal and one rural) from the Secretariat of Beneficial Works of the First Lady
        (SOSEP) system in the Western Highlands in Quetzaltenango, Guatemala.
      
Biospecimen description: 
      Urine, feces, saliva and blood
    
Keywords: Growth; Hematology; Hydration; Oxidation; Infection; Inflammation; Guatemalan children