bioihbjkbjnl/mcl2 huggingface dataset:
Continuous Positive Air Way Pressure in Cardiac Rehabilitation After CABG
Condition: Post-cardiac Surgery
Study type: Interventional

Summary: 
      Different studies reported that CPAP is effective to prevent respiratory complication in post
      CABG patient and have greater impact on walking time, ventilatory function and breathing
      pattern.
    

Detailed description: 
      The walking time (6 minute walk test), effect on arterial blood gasses and long term effects
      of CPAP on cardiac activity, the previous studies focus only on the acute effects of CPAP
      along with specific exercises but did not tell about the long term effects. based on these
      finding this study is design to assess the effectiveness of CPAP in Post-op CABG patients
      regarding there early mobilization, walking time, ABGs and Ejection Fraction as there
      prognostic parameters in both phase-1 cardiac rehabilitation within hospital as well as in
      long-term prognosis, is of great interest.
    

Intervention name(s): Continuous Positive Air Way Group; Control Group
Intervention type(s): Other; Other
Intervention description(s): CPAP between 10 and 12 cmH2O; Day 1: Bed mobility chest physiotherapy, active assistive ROM 5 repetitions of upper and lower limb, ACBT cycle. ABGS was analyses at first minute of exercise and vital was record after exercise.
Day 2: Active range of motion exercise progress with 5 repetitions bed to chair mobility. same exercise progress with 5 repetition and 5 minute walk( day 3rd ).walking time will increase with 10 min at 4 day and at 5th day stair climbing the ABGS was record in ICU 3 days.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Continuous Positive Airway Pressure; Coronary Artery Bypass Graft Surgery; Inpatients Rehabilitations
Localized Muscle Cooling on Balance in Healthy Individuals
Condition: Healthy
Study type: Interventional

Summary: 
      This study aims to investigate the effects of localized muscle cooling on static and dynamic
      stability in healthy adults.
    

Detailed description: 
      Healthy young adult aged 18-30 years will be recruited from the College of Applied Medical
      Sciences (CAMS), King Saud University, Riyadh. Subjects will be excluded if they had a
      history of a hip or knee injury, sensory deficits in the lower extremity, a history of
      lower-extremity surgery, or a history of a quadriceps or hamstring muscle injury. The
      protocol was submitted to and approved by the Ethics Sub-Committee of Rehabilitation Research
      chair (RRC-2018-011). Participants will be requested to sign a written informed consent form
      approved by the institution ethics committee. A total of 50 participants were randomly
      assigned to the quadriceps cooling (QC: n = 10), hamstrings cooling (HC: n = 10), calf
      cooling (CC: n = 10), back muscle cooling (BC: n = 10) or control (no cooling: n = 10) group
      by a lottery method.A baseline assessment of mean center of gravity (COG), sway velocity
      (degrees/sec) for the unilateral Stance (US) will be performed. After the baseline
      assessment, a cold pack (gel pack, temperature -6 degrees to -12 degrees Celsius) will be
      placed on the target muscle for 20 minutes. One thin dry towel will be kept between the cold
      pack and the skin to prevent skin damage. Before and after the application of ice application
      the skin sensibility will be assessed by testing the participant's to a pinprick.
    

Intervention name(s): cooling
Intervention type(s): Behavioral
Intervention description(s): the participants in the experimental group will receive a cold pack (gel pack, temperature -6 degrees to -12 degrees Celsius) will be placed on the target muscles for 20 minutes.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
A Study of RC18 Administered Subcutaneously to Subjects With IgA(Immunoglobulin A) Nephropathy
Condition: IgA Nephropathy
MeSH terms: Kidney Diseases; Glomerulonephritis, IGA
Study type: Interventional
Phase: Phase 2

Summary: 
      To evaluate the safety and efficacy of Tai Ai (Recombinant Human B Lymphocyte Stimulator
      Receptor-Antibody Fusion Protein for Injection) in the treatment of IgA nephropathy.
    


Intervention name(s): RC18 160mg; RC18 240mg; placebo
Intervention type(s): Biological; Biological; Biological
Intervention description(s): subcutaneous injection RC18 160mg on the upper arm, abdomen, or upper thigh outside;; subcutaneous injection RC18 240mg on the upper arm, abdomen, or upper thigh outside;; subcutaneous injection placebo on the upper arm, abdomen, or upper thigh outside;
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
The Impact of Cigarillo Warnings on Purchasing
Condition: Cigar Smoking
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether different cigarillo warning formats
      (pictorial, FDA-proposed text-only, current Surgeon General text-only) reduces demand for
      cigarillos. A previous study has identified that pictorial cigarillo warnings are perceived
      as more effective, but more information is needed on their impact. This study will address
      this issue by randomizing participants to see different cigarillo warning formats on
      cigarillo products within an online experimental tobacco marketplace. Participants will be
      cigarillo users who are ages 21-35.
    

Detailed description: 
      Warning labels on tobacco products convey the health risks and discourage use. Warnings are
      even more effective when they contain images that depict the health consequences. However,
      little is known about the impact of cigarillo warnings, including pictorial warnings, on
      consumer behavior. The Experimental Tobacco Marketplace (ETM) task examines the effects of
      regulations on tobacco purchasing in the context of a complex tobacco marketplace. This
      project aims to address the gap in the knowledge about cigarillo risk communication by
      providing information on best practices for cigarillo warnings. Identifying effective
      cigarillo warnings is important to inform policy and guide research on effectively
      communicating risk to ultimately decrease use and tobacco-related morbidity and mortality.
    

Intervention name(s): Cigarillo warnings-Surgeon General Text-Only; Cigarillo warnings-FDA proposed text-only; Cigarillo warnings-Pictorial
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Participants will complete 6 mock shopping trips in the Experimental Tobacco Marketplace, and be asked to spend their weekly tobacco budget. Cigarillos in the Marketplace will have one of three cigarillo warnings in the Surgeon General Text-Only format.; Participants will complete 6 mock shopping trips in the Experimental Tobacco Marketplace, and be asked to spend their weekly tobacco budget. Cigarillos in the Marketplace will have one of three cigarillo warnings in the FDA Proposed Text-Only format.; Participants will complete 6 mock shopping trips in the Experimental Tobacco Marketplace, and be asked to spend their weekly tobacco budget. Cigarillos in the Marketplace will have one of three cigarillo warnings in the Pictorial format.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The study will conduct a three-group, between-subjects experiment to compare varying cigarillo warning formats: Surgeon General text-only, FDA-proposed text-only, and study developed pictorial cigarillo warning labels.
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Cigarillo smoking; Cigarillo packaging warnings
Is There Room for Butter in a Healthy Diet?
Condition: Atherosclerosis
MeSH terms: Atherosclerosis
Study type: Interventional

Summary: 
      The aim of this study is to examine the effects in humans of a moderate butter intake on risk
      markers of cardiovascular disease compared to a diet with the same amount of olive oil
      (refined and therefore without polyfenols).

      The primary parameters are total cholesterol, LDL- and HDL cholesterol and triglycerides. The
      secondary parameters are risk markers of diabetes type 2; plasma glucose and insuling as well
      as the inflammatory marker hs-CRP.
    


Intervention name(s): Danish butter; Olive oil
Intervention type(s): Other; Other
Intervention description(s): The effect of butter intake versus olive oil (refined) intake on blood lipids (primarily)
Other intervention name(s): butter, diary
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Time Effect of the Pressure Release Technique Application in the Latent Myofascial Trigger Points
Condition: Myofascial Pain Syndrome
MeSH terms: Myofascial Pain Syndromes; Fibromyalgia
Study type: Interventional

Summary: 
      Background: Latent myofascial trigger points (MTrPs) of the levator scapulae are high
      prevalent and may influence the neck and shoulder conditions. The pressure release is one of
      the most recommended manual therapy techniques.

      Objective: To determine the time effect of the pressure release technique application in the
      latent MTrPs of the levator scapulae muscle.

      Design: A three-arm (1:1:1 ratio), double-blinded, parallel, randomized clinical trial.

      The manual technique than us apply, be sustained digital pressure with thumbs or with the
      2nd-3rd fingers on the PGM below the pain threshold and gradually increases up to a ceiling
      of tissue resistance (barrier), as decreases, adds more pressure. different times of
      sustained pressure and the number of repetitions depending on time 30 (group 1, acts as a
      control), 60 (group 2) and 90 seconds (group 3) shall apply.
    


Intervention name(s): Pressure release 90; Pressure release 60; Pressure release 30
Intervention type(s): Other; Other; Other
Intervention description(s): This is a massage technique that aims is eliminate myofascial trigger points for to treat muscle pain.; This is a massage technique that aims is eliminate myofascial trigger points for to treat muscle pain.; This is a massage technique that aims is eliminate myofascial trigger points for to treat muscle pain.
Other intervention name(s): soft tissue massage; Compression ischemic massage technique; Compression ischemic massage technique; soft tissue massage; Compression ischemic massage technique; soft tissue massage
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Myofascial Trigger Points; Liberation for Pression; Therapy Soft Tissue
Study to Evaluate the Effect of XmAb®5871 on Disease Activity in Patients With IgG4-Related Disease (RD)
Condition: IgG4-RD
MeSH terms: Immunoglobulin G4-Related Disease
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this Phase 2 study is to investigate the effect of XmAb5871 on IgG4-Related
      Disease (RD) activity
    


Intervention name(s): XmAb5871
Intervention type(s): Biological
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
PK, PD, Tolerability and Safety of MDPK67b in Healthy Volunteers
Condition: Prostatic Neoplasms
MeSH terms: Prostatic Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a Phase I, single centre, prospective, randomized, alternating panels, ascending
      doses with interspersed placebo, double-blind, crossover trial.

      The trial will include 8 volunteers divided into 2 panels (A and B) investigated in
      alternance, each submitted to 4 investigation periods following a crossover design in double
      blind, with ascending intravenous doses of MDPK67b and an interspersed placebo.

      The ascending dose sequence ranges from 2 to 48 mg, with 2-fold increase steps (3 to 4- fold
      increase steps in each individual volunteer). Three single doses will be administered at a
      minimum of 2 weeks intervals during the first 3 periods, and finally during the last period 4
      repeated doses will be administered at a three days intervals, using either the highest dose
      of the ascending sequence (i.e. 24 or 48 mg) or the maximal tolerated dose (if it has been
      exceeded in the ascending sequence of single doses).
    


Intervention name(s): MDPK67b; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Two subgroups (Panels A and Panel B) of four subjects were to be randomly allocated either to placebo or to three increasing doses of MDPK67b, administered as single infusion at intervals of at least two weeks during the first three periods with the last period involving four repeated doses administered at three-day intervals.; Two subgroups (Panel A and Panel B) of four subjects were to be randomly allocated either to placebo or to three increasing doses of MDPK67b, administered as single infusion at intervals of at least two weeks during the first three periods with the last period involving four repeated doses administered at three-day intervals.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Serial Fasciculation Measurements in Motor Neurone Disease
Condition: Motor Neuron Disease; Benign Fasciculation-Cramp Syndrome
MeSH terms: Motor Neuron Disease; Amyotrophic Lateral Sclerosis; Fasciculation; Neuromuscular Diseases
Study type: Interventional

Summary: 
      Patients with motor neurone disease (MND) typically experience relentless motor decline and
      die within three years of symptom onset from respiratory muscle weakness. There are currently
      no effective therapies and the discovery of novel therapies is hampered by the lack of a
      sensitive disease biomarker. Consequently, there is a huge drive to discover novel
      biomarkers, which can reliably track disease progression over time. These can then be
      incorporated into clinical drug trials to expedite effective drug discovery.

      Muscle fasciculations represent the hyperexcitability of diseased motor neurons and are
      almost universally present from the early stages of MND. The investigators predict that the
      site, frequency and shape of fasciculations might provide a sensitive measure of disease
      progression in an individual.

      In order to calibrate this technique, the investigators will conduct a 12-month longitudinal
      study, recruiting 24 patients from the King's College Hospital Motor Nerve Clinic, comprising
      a mixture of patients with MND and those with benign fasciculation syndrome. Patients in this
      latter group have fasciculations but do not develop weakness and have normal lifespans. They
      are therefore an optimal control group. At each visit, the investigators will take resting
      HDSEMG recordings from all four limbs and perform standard clinical measures of disease
      progression. The investigators will also monitor the decline in motor unit number using a
      newly validated neurophysiological technique, called Motor Unit Number Index (MUNIX).
    


Intervention name(s): High-density surface electromyography
Intervention type(s): Device
Intervention description(s): High-density surface electromyography
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: 20 Motor Neuron Disease (MND) patients and 5 Benign Fasciculation Syndrome (BFS) patients undergoing same assessments at 2-monthly intervals for one year
Masking: None (Open Label)
Primary purpose: Other
A Double-Blind, Placebo-Controlled Study With Open-Label Follow-Up To Determine the Safety and Efficacy of r-HuEPO in AIDS Patients With Anemia Induced by Their Disease and AZT Therapy
Condition: HIV Infections; Cytopenias
MeSH terms: HIV Infections; Anemia
Study type: Interventional

Summary: 
      To determine the safety and efficacy of erythropoietin administered to AIDS patients with
      anemia secondary to their disease and/or concomitant zidovudine (AZT) therapy.
    


Intervention name(s): Epoetin alfa
Intervention type(s): Drug
Intervention MeSH terms: Epoetin Alfa
Masking: Double
Primary purpose: Treatment
Keywords: Recombinant Proteins; Erythropoietin; Acquired Immunodeficiency Syndrome; Anemia; Zidovudine
An Assessment of Voluntary Adolescent Mental Health Screening and Referral in a Children's Hospital Emergency Department
Condition: Mental Health
MeSH terms: Emergencies
Study type: Interventional

Summary: 
      The purpose of this study is to compare the TeenScreen intervention to usual care for
      adolescents who screen positive for mental health problems in a pediatric emergency
      department. It is anticipated that adolescents receiving the TeenScreen intervention will be
      more likely to attend a first session of outpatient mental health services within 60 days of
      the initial screening than those receiving the usual care.
    


Intervention name(s): TeenScreen Program
Intervention type(s): Behavioral
Intervention description(s): Adolescents who are randomized into the TeenScreen program and their parent/guardian will receive post-screening information, a facilitated referral, and case management services from a research social worker.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: TeenScreen; Mental Health; Adolescent Mental Health; Social Work
Effects of Aquamin F on Osteoarthritis of the Knee
Condition: Osteoarthritis of the Knee
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The objective of this trial is to evaluate the effect of Aquamin F alone or in combination
      with glucosamine sulfate versus placebo on symptoms of joint pain, stiffness and immobility
      in subjects with painful osteoarthritis of the knee. The following hypotheses were tested:

      (Hypothesis 1) After 12 weeks of treatment, subjects taking Aquamin F alone or in combination
      with glucosamine sulfate will have significantly less joint pain, stiffness and immobility
      compared to subjects taking glucosamine sulfate alone or placebo alone.

      (Hypothesis 2) No significant differences will be seen for adverse events between the
      subjects taking Aquamin F, glucosamine sulfate, Aquamin F + glucosamine sulfate or placebo.
    

Detailed description: 
      Method: Subjects were randomized to receive 12 weeks of Glucosamine sulfate vs Aquamin F vs
      Placebo vs Aquamin F + Glucosamine sulfate while controlling for pain with acetaminophen.
      Subjects were then followed for blood chemistry measurements only over an additional 12-week
      period specifically to assess blood calcium levels post treatment. All participants were
      subjected to the same diet and exercise regimen and measurements included: WOMAC scores
      (pain, stiffness, mobility, total score), 6 Minute Walking Distances, active and passive
      range of motion measurements, DXA scans, blood chemistry, hematology, CRP levels and lipid
      profiles as well as rescue medication diary measurements and adverse event assessments. An
      independent statistician analyzed the data using independent t-tests and ANCOVA for
      between-group comparisons and matched-pair t-tests for within-group comparisons of patients
      included in ITT-LOCF and completer analyses.
    

Intervention name(s): Aquamin F
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Osteoarthritis; Clinical trial; Aquamin F; Glucosamine
Bioequivalence Study of Amoxicillin 400 mg/Clavulanic Acid 57 mg Chewable Tablets Under Fasting Conditions
Condition: Healthy
Study type: Interventional

Summary: 
      The objective of this study was to compare the single-dose relative bioavailability of
      Ranbaxy and GlaxoSmithKline (Augmentin®) 400 mg amoxicillin (as the trihydrate) and 57 mg
      clavulnic acid (as the potassium salt) chewable tablet, following administration of 2 tablet
      dose under fasting conditions
    

Detailed description: 
      The study was conducted as an open-label, randomized, 2-way crossover study to compare the
      single-dose relative bioavailability of Ranbaxy and GlaxoSmithKline (Augmentin® 400 mg)
      amoxicillin (as the trihydrate)/57 mg clavulanic acid (as the potassium salt) chewable
      tablet, following administration of 2 tablet dose under fasting conditions A total of 40
      subjects (22 males and 18 females) were included in this study, of which 39 (21 males and 18
      females) finished the study according to the protocol.
    

Intervention name(s): amoxicillin 400mg + clovalunic acid 57.5mg tablets
Intervention type(s): Drug
Intervention MeSH terms: Amoxicillin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: Bioequivalence
Intraprocedural Assessment of Ablation Margins Using Computed Tomography Co-registration in Primary Liver Tumor Treatment With Percutaneous Ablation
Condition: HCC
MeSH terms: Liver Neoplasms
Study type: Interventional
Phase: Phase 2

Summary: 
      A pre- and postablation scan will be made intraprocedurally to investigate the feasibility of
      intraprocedural ablation verification assessment using coregistration software
    


Intervention name(s): Additional intraprocedural pre-ablation CT-scan
Intervention type(s): Diagnostic Test
Intervention description(s): In 20 patients, besides de regular post-RFA scan, a pre-RFA contrast enhanced dual phase CT-scan will be acquired to investigate the feasibility of quantitative ablation assessment.
Intervention model: Single Group Assignment
Intervention model description: prospective, single blind, single-arm, phase II stud
Masking: None (Open Label)
Primary purpose: Treatment