Difference Between Interval and Continous Intradialytic Exercise on Functional Capacity in Hemodialysis Patient
Condition: Hemodialysis Complication
Study type: Interventional

Summary: 
      The goal of this study is to find out the effect of interval versus continous intradialytic
      training on muscle quality index and functional capacity in Hemodialysis patients. The main
      question it aims to answer is:

      Does interval versus continous intradialytic training have an effect on muscle quality index
      and functional capacity in hemodialysis patients? Patients will be assigned randomly by
      computerized block randomization into two groups:Group (A): 30 patients will participate in 8
      weeks of aerobic exercise in the form of high intensity interval training (HIIT)
      intradialytic pedaling exercise plus hemodialysis (3 sessions per week).Group (B): 30
      patients will participate in 8 weeks of aerobic exercise in the form of moderate intensity
      continous training (MICT) intradialytic pedaling exercise plus hemodialysis (3 sessions per
      week) . primary and secondary variables will be measured before starting treatment and after
      completion (after 2 months )
    

Detailed description: 
      Individuals with CKD (both predialysis and ESRD) may be at greater risk of sarcopenia given
      the combined reductions in physical function, skeletal muscle performance and skeletal muscle
      mass.

      Study include sixty male patients on hemodialysis for 1-3 years aged from 45 to 55 years old
      selected from hemodialysis unit at National Institute of Urology and Nephrology. Before
      starting treatment , patients will fill consent form and the study aims and procedure will be
      explained to each patient . study include Sixty male patients on hemodialysis for 1-3 years
      aged from 45 to 55 years old selected from hemodialysis unit at National Institute of Urology
      and Nephrology. Patients will be assigned randomly by computerized block randomization into
      two groups:Group (A): 30 patients will participate in 8 weeks of aerobic exercise in the form
      of high intensity interval training (HIIT) intradialytic pedaling exercise plus hemodialysis
      (3 sessions per week).Group (B): 30 patients will participate in 8 weeks of aerobic exercise
      in the form of moderate intensity continous training (MICT) intradialytic pedaling exercise
      plus hemodialysis (3 sessions per week) Karvonen formula will be used to calculate training
      heart rate THR= RHR+ (HRmax - RHR) 65%-80% AS HRmax = 220-Age patients of HIIT will perform
      aerobic exercise in the form of leg pedaling exercise in semi-supine position using leg
      ergometer at high intensity 85%-95% of HRpeak with 4 min of active breaks at an intensity of
      60%-70% of HRpeak. . Exercise will be done at the first 2 hours of dialysis (to avoid
      dialysis hypotension episodes).

      patients of MICT will perform aerobic exercise in the form of leg pedaling exercise in
      semi-supine position using leg ergometer at moderate intensity 50%-60% of HRpeak . Exercise
      will be done at the first 2 hours of dialysis (to avoid dialysis hypotension episodes).

      primary and secondary variables will be measured before starting treatment and after
      completion (after 2 months )
    

Intervention name(s): Aerobic pedaling exercise
Intervention type(s): Other
Intervention description(s): aerobic exercise in the form of leg pedaling exercise in semi-supine position using leg ergometer by different intensities
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Patients will be assigned randomly by computerized block randomization into two groups:Group (A): 30 patients aged between 45 - 55 years old will participate in 8 weeks of aerobic exercise in the form of high intensity interval training (HIIT) intradialytic pedaling exercise plus hemodialysis (3 sessions per week).
Group (B): 30 patients aged between 45- 55 years old will participate in 8 weeks of aerobic exercise in the form of moderate intensity continous training (MICT) intradialytic pedaling exercise plus hemodialysis (3 sessions per week).
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment