bioihbjkbjnl/mcl2 huggingface dataset:
Early Neurocognitive Rehabilitation in Intensive Care
Condition: Critical Illness
MeSH terms: Critical Illness
Study type: Interventional

Summary: 
      The purpose of this project is to assess the efficacy of an early neurocognitive intervention
      for ICU patients, in terms of psychopathological, neuropsychological and functional
      improvement. The treatment is supported in an interactive advanced computing platform that
      includes the continuous biomedical registration of the patients and a virtual reality
      software specifically designed for critical patients.

      The investigators expect an improvement in neuropsychological, psychopathological and
      functional status at hospital discharge and 3 months follow-up in those patients that have
      received the early neurocognitive intervention comparing with patients treated as usual.
      Furthermore the investigators expect a decrease of episodes and/or duration of delirium in
      ICU patients.
    


Intervention name(s): Neurocognitive stimulation
Intervention type(s): Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Critical illness; Neurocognition; Neurocognitive stimulation; Delirium; Virtual Reality; cognitive; rehabilitation; ICU
A School-based Prevention Intervention to Promote Wellbeing in Preadolescents
Condition: Major Risk Factors for Noncommunicable Diseases
MeSH terms: Noncommunicable Diseases
Study type: Interventional

Summary: 
      This is a field study aiming to evaluate a school-based prevention intervention, Diario della
      Salute (DDS).
    

Detailed description: 
      Diario della Salute (DDS) is a school-based prevention intervention based on the following
      theories:

        1. social-cognitive theory (Bandura, 1977; 1986)

        2. theory of multiple intelligences (Gardner, 1987)

        3. emotional intelligence theory (Goleman, 1997)

        4. theory of planned behavior (Ajzen, 1991)

        5. transtheoretical model of change (Prochaska, Diclemente, 1982; 1992).

      DDS is composed by:

        1. tools for children and their parents on health and social and emotional well-being
           issues:

             1. a diary for teens telling the story of four same-age students (e.g. experimenting
                with risky behaviors, conflicting feelings and thoughts, need for independence and
                control),

             2. a diary for parents telling the experience of a mum and a dad with teenage children
                (e.g. problems in the relationship with teenage children, family conflict, parental
                disappointment, etc.);

        2. five highly-standardized interactive lessons (2-4 hours each) on health issues
           administered by previously trained teachers.

      Assignment of schools to study arms (DDS intervention vs. no intervention) will be
      cluster-randomized. Schools will be matched by number of students and average socioeconomic
      status. In some study areas schools will not be allocated by chance, but they will be
      analyzed separately from other schools.

      Two anonymous surveys focusing on main outcomes (wellbeing, tobacco smoking, alcohol,
      physical activity and diet) will be before and after the intervention. Pre and post surveys
      will be linked through an anonymous code (Galanti, 2006).
    

Intervention name(s): Diario della Salute (DDS)
Intervention type(s): Other
Intervention description(s): DDS is composed by
tools for children and their parents on health and social and emotional well-being issues:
a diary for teens telling the story of four same-age students (e.g. experimenting with risky behaviors, conflicting feelings and thoughts, need for independence and control),
a diary for parents telling the experience of a mum and a dad with teenage children (e.g. problems in the relationship with teenage children, family conflict, parental disappointment, etc.);
five highly-standardized interactive lessons (2-4 hours each) on health issues administered by previously trained teachers.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: universal prevention; primary prevention; health promotion; wellbeing; smoking; alcohol; diet; physical activity; emotional and social skills
Measuring Droplets in Children
Condition: Droplet Spread
Study type: Interventional

Summary: 
      This study will measure the size and quantity of respiratory particle production in children
      under a variety of conditions, including face coverings/masks and various common activities.
    


Intervention name(s): Various commercially available face coverings
Intervention type(s): Device
Intervention description(s): Various commercially available face coverings
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
A Comparative Study of Intrathecal Magnesium Sulphate & Midazolam With Epidural Ropivacaine for Caesarean Patients
Condition: Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      This study compares whether addition of Magnesium or Midazolam intrathecally to epidurally
      administered isobaric Ropivacaine improves the quality of blockade, haemodynamics and
      duration of analgesia post-operatively. 25 parturients were given intrathecal Magnesium and
      rest of the 25 parturients were given intrathecal Midazolam combined with 0.75% Ropivacaine
      via epidural route.
    

Detailed description: 
      Magnesium sulphate and Midazolam have been used in clinical trials as adjuvants to local
      anaesthetics via intrathecal and epidural routes and are effective in augmenting the quality
      of block and prolonging post-operative analgesia.

      Noxious stimulation leads to the release of glutamate and aspartate neuratransmitters which
      bind to various sub-classes of excitatory aminoacid, including the NMDA receptor. Intrathecal
      magnesium potentiates neuraxial anaesthesia by blocking NMDA receptors with out causing
      significant side effects as reported in various studies.

      Intrathecal Midazolam produces antinociception at spinal cord-level through benzodiazepine
      GABA-A receptor complex which are present abundantly in the lamina 2 of spinal cord.
      Midazolam also releases endogenous opioid acting at spinal delta receptors and also enhances
      adenosine release which also augments analgesia.
    

Intervention name(s): intrathecal magnesium sulphate,; Intrathecal midazolam
Intervention type(s): Drug; Drug
Intervention description(s): comparision of effects of intrathecal magnesium sulphate with intrathecal midazolam when administered along with epidural 0.75% Ropivacaine; comparision of effects of intrathecal magnesium sulphate with intrathecal midazolam when administered along with epidural 0.75% Ropivacaine
Other intervention name(s): Magneon; Mizolam
Intervention MeSH terms: Magnesium Sulfate; Midazolam
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: magnesium sulphate; intrathecal route; midazolam
A Study of Crenezumab in Participants With Mild to Moderate Alzheimer Disease
Condition: Alzheimer Disease
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      This randomized, placebo-controlled, double-blind, parallel-arm study will evaluate the
      safety and tolerability of at least two dose levels of intravenous (IV) crenezumab in 24-72
      participants with mild to moderate Alzheimer disease (AD) (mini-mental state examination
      [MMSE] 18 to 28 points, inclusive). An optional open-label extension (OLE) will be offered
      after the completion of initial double-blind stage.
    


Intervention name(s): Crenezumab dose level 1; Crenezumab dose level 2; Crenezumb dose level 3; Placebo
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Participants will receive crenezumb dose level 1 IV infusion once every 4 weeks up to Week 13 in double-blind treatment window or up to Week 61 in optional OLE window.; Participants will receive crenezumb dose level 2 IV infusion once every 4 weeks up to Week 13 in double-blind treatment window or up to Week 61 in optional OLE window.; Participants will receive crenezumb dose level 3 IV infusion once every 4 weeks upto Week 13 in double-blind treatment window or up to Week 61 in optional OLE window.; Participants will receive placebo matched to crenezumab IV infusion once every 4 weeks upto Week 13 in double-blind treatment window.
Intervention MeSH terms: Antibodies, Monoclonal
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Opt-In Versus Opt-Out for Colorectal Cancer Screening Outreach
Condition: Cancer of the Colon
MeSH terms: Colonic Neoplasms
Study type: Interventional

Summary: 
      This is a randomized controlled pilot study aimed at testing different outreach strategies
      (opt-in versus opt-out) to increase colorectal cancer screening through completion of mailed
      home fecal immunohistochemical testing (FIT).
    

Detailed description: 
      This is a randomized controlled pilot study aimed at testing different outreach strategies to
      increase colorectal cancer screening using mailed fecal immunohistochemical testing (FIT).
      The investigators will randomize a cohort of subjects between the ages of 50-74 into 2 arms:

        1. Opt-In - subject must actively choose to receive a home FIT kit.

        2. Opt-Out - a FIT kit is sent as a default unless the subject actives chooses not to
           receive the kit or reports prior screening.
    

Intervention name(s): Opt-In Outreach; Opt-Out Outreach
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Subjects will receive a communication (mail or electronic) describing the importance of colorectal cancer screening with the option to elect to receive a home FIT kit or report prior screening.; Subjects will receive a communication (mail or electronic) describing the importance of colorectal cancer screening with the option to choose not to receive a home FIT kit or report prior screening. A FIT kit will otherwise be sent to the subject as a default.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Screening
Dual Endpoint Nerve Stimulation Versus Ultrasound in Infraclavicular Block for Hand Surgery
Condition: Hand Surgery
Study type: Interventional

Summary: 
      Current best practice for performance of infraclavicular block dictates the use of a
      dual-endpoint nerve stimulation technique that still only results in a 79% success rate. Use
      of an ultrasound-guided technique has the potential to significantly improve success. A
      randomized, controlled study to evaluate this area remains to be performed and is required to
      demonstrate to anesthesiologists that an ultrasound-guided approach should supersede nerve
      stimulation as the technique of choice for infraclavicular block.
    


Intervention name(s): Ultrasound Guided Infraclavicular Nerve Block; Dual-Endpoint nerve stimulation
Intervention type(s): Procedure; Procedure
Intervention description(s): Use of Ultrasound to help guide needle placement and local anesthetic injection during infraclavicular nerve block.; Use of dual-endpoint nerve stimulation to guide needle placement and local anesthetic injection during infraclavicular nerve block.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: infraclavicular nerve block ultrasound dual endpoint stimulation
Duration of Protection: GSK DTaP Vaccines
Condition: Diphtheria; Acellular Pertussis; Tetanus
MeSH terms: Diphtheria
Study type: Observational

Summary: 
      The purpose of this study is to assess duration of protection for GSK DTaP vaccines in
      preventing pertussis.
    


Intervention name(s): Infanrix; Pediarix; Kinrix
Intervention type(s): Biological; Biological; Biological
Intervention description(s): Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed Indicated as a 5-dose series in infants and children 6 weeks to 7 years of age.; Diphtheria and Tetanus Toxoids and Acellular Pertussis Ad-sorbed, Hepatitis B (Recombinant) and Inactivated Poliovirus Vaccine Indicated as a 3-dose series in infants born of hepatitis B surface antigen (HBsAg)-negative mothers. PEDIARIX may be given as early as 6 weeks of age through 6 years of age (prior to the 7th birthday).; Diphtheria and Tetanus Toxoids and Acellular Pertussis Ad-sorbed and Inactivated Poliovirus Vaccine
Sampling method: Non-Probability Sample
Study population: 
        Kaiser Permanente Northern California (KPNC) member who received 5 doses of acellular
        pertussis vaccines between ages 1 month and 84 months at KPNC.
Respiratory Muscle Training and Intermittent Hypoxia: Additive Health Effects?
Condition: Pre-Hypertension
MeSH terms: Prehypertension; Hypoxia
Study type: Interventional

Summary: 
      The prevalence of pre-hypertension and hypertension in the elderly is very high. Apart from
      medication, physical exercise training is a potential strategy to reduce blood pressure,
      however, the ability to perform exercise can be limited in the elderly. Hence, alternative
      non-pharmacological strategies to reduce blood pressure are necessary. Two interventions that
      have been shown to positively influence blood pressure are respiratory muscle training (RMT)
      and intermittent hypoxia (IH). Whether a combination of RMT and IH yields even better effects
      is currently unknown. Therefore, in this study, the effect of a single session of RMT with
      and without IH on blood pressure and associated cardiovascular parameters will be
      investigated in elderly subjects with pre-hypertension.
    


Intervention name(s): RMT; RMT + IH; Control
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): RMT consists of six bouts of 5-min of volitional hyperpnoea . After each RMT bout, participants will breathe room air for 5 minutes.; RMT and IH consist of six bouts of 5-min of volitional hyperpnoea. After each RMT bout, participants will breathe a hypoxic gas mixture (10.5% O2 ) for 5 minutes.; No intervention
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Visual Based Program and Climate Change
Condition: Anxiety State; Efficacy, Self
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      Climate change represents a global crisis with far-reaching implications for health,
      including mental health. Among vulnerable populations, such as nursing students, climate
      change anxiety is emerging as a noteworthy concern. Recognizing the need to address this
      issue, our research aims to investigate the impact of a virtual-based program on climate
      change awareness, anxiety levels, and self-efficacy among nursing students. As future
      healthcare professionals, nursing students play a pivotal role in promoting sustainable
      health practices and addressing the health impacts of climate change. This study seeks to
      contribute valuable insights into the effectiveness of virtual interventions in raising
      awareness and enhancing the coping mechanisms of nursing students in the face of climate
      change challenges.
    

Detailed description: 
      Aim:

      To investigate the impact of a virtual-based awareness program on climate change anxiety,
      awareness, and self-efficacy among nursing students through a randomized control study.

      The anticipated outcome is that the virtual-based program will positively influence nursing
      students' climate change perceptions, reduce climate change anxiety, and enhance
      environmental self-efficacy. The outcome will be assessed through pre- and post-intervention
      measurements using the respective tools, providing insights into the program's effectiveness
      in addressing these psychological and behavioral aspects related to climate change awareness
      and action among nursing students.
    

Intervention name(s): virtual based climate change program
Intervention type(s): Behavioral
Intervention description(s): The Interactive digital-based educational program Sessions:
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Effects of a Single OMT on Intraocular Pressure (IOP) in Ocular Hypertenive or Glaucoma Suspect Subjects
Condition: Ocular Hypertension; Glaucoma
MeSH terms: Glaucoma; Ocular Hypertension
Study type: Interventional

Summary: 
      The hypothesis is that osteopathic manipulative treatment (OMT)will significantly reduce
      intraocular pressure (IOP) in individuals with ocular hypertension (OHT) and glaucoma suspect
      patients.
    

Detailed description: 
      Glaucoma is a leading cause of irreversible blindness in the United States and the world.
      Approximately 2.8 million Americans have been diagnosed with glaucoma. Based on pilot studies
      and the clinical experience of the PI, a power analysis indicated that in order to lower IOP
      by 4 mm Hg 28 subjects would be needed, 14 in the experimental group and 14 in the
      control/comparator group.

      The intervention is OMT. Based on the anatomy of the eye and the dysfunctions underlying
      primary open angle glaucoma (POAG), the presumed mechanisms are one or the other or a
      combination of the following. 1) Anatomic: the OMT benefit may occur by the biomechanical
      restoration of drainage through the trabecular meshwork and Schlemm's canal. 2) Neurologic:
      the OMT may affect the parasympathetic innervations from the Edinger-Westphal fibers via the
      cranial nerve III as well as the sympathetic innervations arising in the T1 to T3 levels then
      via the superior cervical ganglion which then course to the eye.

      The OMT protocol takes 25-27 minutes to administer and addresses cranial, cervical, upper
      body, spinal and sacral structures designed to affect the anatomic, physiologic processes
      (e.g. lymphatic drainage from the neck and face), neurologic structures (sympathic and
      parasympathetic) affecting visual processes. A very similar OMT protocol was used in a study
      on healthy elder and resulted in improved balance and equilibrium. In that study there were
      no adverse outcomes reported.

      The control/comparator subjects will lay on the OMT table for the same 25-27 minutes in the
      same time periods in which experimental subjects were in the prone, lateral recumbent, and
      supine positions.
    

Intervention name(s): osteopathic manipulative treatment (OMT); osteopathic manipulative treatment (OMT)
Intervention type(s): Procedure; Procedure
Intervention description(s): OMT is a form of manual medicine performed by osteopathic physicians
Other intervention name(s): OMT is a form of manual medicine
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Aromatherapy Protocol for Pain Reduction in Hospice Patients
Condition: Pain
Study type: Interventional

Summary: 
      The purpose of this study is to introduce aromatherapy with current pain medication protocols
      to see if it improves patient satisfaction and reduces pain in hospice care patients.
    


Intervention name(s): Aromatherapy treatment
Intervention type(s): Other
Intervention description(s): 60 minutes after pain medication administration primary investigator will turn on the diffuser (manufacture ScentSationals)and administer aromatherapy with a mixture of four drops of lavender and four drops of peppermint for 60 minutes.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: hospice care
Iron & Vitamin C Study
Condition: Spinal Cord Injury
MeSH terms: Spinal Cord Injuries
Study type: Observational

Summary: 
      Iron overload is a life-threatening condition that can lead to liver disease, cardiac
      disease, diabetes and arthritis. Simultaneous supplementation with both iron and AA may place
      individuals with SCI at risk for iron overload as well as oxidative damage by iron-generated
      free radicals. Both conditions of high and low iron stores may present with common signs and
      symptoms. Accurate diagnosis of iron disorder should consider CRP, hematocrit, hemoglobin,
      serum iron, TIBC, percent saturation of iron binding capacity, serum ferritin and hepcidin.

      The investigators are proposing a study to determine the effect of concurrent AA and iron
      supplementation on iron status of individuals with SCI. The investigators goal is to identify
      abnormal status that may be attributed to simultaneous supplementation of iron and AA to
      develop future supplementation protocols in this population for optimal iron status.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        US Veterans with spinal cord injuries greater than 6 months who are located near Bronx, NY
      
Biospecimen description: 
      Blood samples will be obtained for analysis.
    
Keywords: Spinal Cord Injuries; Ascorbic Acid; Vitamin C; Iron; Dietary Supplements
The Use of Quantitative Pregnancy Test in Amniotic Fluid as a Diagnostic Tool for Rupture of Fetal Membranes
Condition: Premature Rupture of Membrane
MeSH terms: Premature Birth; Fetal Membranes, Premature Rupture; Rupture
Study type: Interventional

Summary: 
      Two groups will be recruited. The first group are pregnant ladies that have unequivocal
      rupture of fetal membranes that is diagnosed by seeing the amniotic fluid leakage in the
      vagina. The second group are normal pregnant ladies without rupture of membranes. both groups
      will be tested by taking vaginal washing fluid. Quantitative and qualitative pregnancy tests
      will be measured in this fluid.
    

Detailed description: 
      Beta subunit of human chorionic gonadotropin assay will be measured in the vaginal washing in
      two groups. The first group are pregnant women in the second or third trimester. These women
      have definite rupture of membranes diagnosed by visual leaking of the amniotic fluid from the
      cervix during speculum examination. The second group are pregnant women with intact
      membranes. Assessment of both the qualitative and quantitative beta subunit of human
      chorionic gonadotropin will be done
    

Intervention name(s): assessment of beta subunit of human chorionic gonadotropin
Intervention type(s): Diagnostic Test
Intervention description(s): Vaginal washing fluid will be collected and sent for measurement of beta subunit of human chorionic gonadotropin
Intervention MeSH terms: Chorionic Gonadotropin
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Diagnostic