bioihbjkbjnl/mcl2 huggingface dataset:
Temperature Measurement in Post-Anesthesia Care Units
Condition: Surgery; Postoperative; Laparoscopic Surgery; General Anesthesia
Study type: Observational

Summary: 
      This study will evaluate the accuracy of several thermometers and temperature changes during
      surgery and immediately after surgery.
    

Detailed description: 
      Several measurements of temperature will be taken at 30 minute intervals during surgery under
      general anesthesia and in the post operative care unit. Measurements will be taken as
      follows:

        -  esophagus using an internal stethoscope

        -  urinary bladder using a catheter

        -  ear canal

        -  skin of the forehead using adhesive devices(4 thermometers)

        -  axilla ("armpit") using adhesive devices(2 thermometers)

        -  mouth

        -  skin of the upper chest
    

Intervention name(s): Body temperature thermometers
Intervention type(s): Device
Intervention description(s): Temperature readings every 30 minutes during and post surgery using internal stethoscope, catheter and adhesive patches/electronic thermometer.
Other intervention name(s): 1. Distal esophagus (Mon-a-therm, Tyco-Mallinckrodt Anesthesia Products,; 2. Bladder (Mon-a-therm, Tyco-Mallinckrodt Anesthesia Products,; 3. Infrared-aural canal bilaterally (GENIUS Model 3000A, Kendall Healthcare); 4. Temporal artery with an electronic scanning thermometer (Model TAT-5000, Exergen); 5. Posterior sublingual pocket with electronic thermometer (Turbo Temperature Model 2180CX01EE); 6. Forehead skin thermocouple (Mon-a-therm, Tyco-Mallinckrodt Anesthesia Products); 7. Axilla with an electronic probe (Mon-a-therm, Tyco-Mallinckrodt Anesthesia Products); 8. Forehead liquid-crystal (Crystaline II); 9. Intermittent axillary temperature (Turbo Temperature Model 2180CX01EE); 10. "Deep" temperature with a 4-cm probe on the forehead; 11. "Deep" temperature with a 7-cm probe over the subclavicular region of the upper chest
Intervention MeSH terms: Anesthetics
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients undergoing laparoscopic surgery requiring general anesthesia and a bladder
        catheter.
      
Keywords: temperature; monitor; surgery
Fludeoxyglucose (FDG) Positron Emission Tomography/Computed Tomography (PET/CT) Cervical Heterogenity Imaging Study
Condition: Cervical Cancer
MeSH terms: Uterine Cervical Neoplasms
Study type: Interventional

Summary: 
      Rationale: Diagnostic procedures, such as positron emission tomography (PET) using
      fluorodeoxyglucose (FDG), may help determine response to standard cancer therapy in patients
      with cervical cancer

      The purpose of this study is to evaluate the change in cervical tumor heterogenity as
      measured by FDG-PET/CT imaging.
    


Intervention name(s): Positron Emission Tomography
Intervention type(s): Procedure
Intervention description(s): FDG PET/CT imaging is performed at baseline, after 2 and 4 weeks of radiation therapy and approximately 3 months after chemoradiation is completed
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Cervical Cancer; Positron Emission Tomography; Fluorodeoxyglucose
Treatment of Hidradenitis Suppurativa With Eth 755nm Alexandrite Laser
Condition: Hidradenitis Suppurativa
MeSH terms: Hidradenitis Suppurativa; Hidradenitis
Study type: Interventional

Summary: 
      Patients with bilateral hidradenitis in the axilla, groin and/or inframammary will be treated
      on one side with the Alexandrite hair removal laser. The other side will serve as the
      control.
    

Detailed description: 
      Patients with bilateral disease will be chosen to participate in the study. Patients will be
      advised to discontinue any prior systemic HS treatments two weeks before their first laser
      session as a wash out period. One side of the patient will be chosen as the treatment side,
      the other as an intrinsic control. Each participant will have a total of 4 treatments with
      the laser, one treatment per month over the duration of 4 months. Patients will then
      participate in a follow-up clinic visit two months after completion of their last treatment.
      In between laser sessions, participants will be allowed to use benzoyl peroxide 10% wash as a
      skin cleanser and clindamycin 1% solution or lotion as a topical therapy, both twice daily to
      the treatment and control areas. At each visit, photographs will be taken of the lesions to
      monitor progression and to serve as a comparison to the control side. The treatment side will
      be treated with the laser and adjusted according to skin type as follows:

      Skin type I-II (Fair Caucasian): Fluence: 30J/cm2 Skin type III (Darker Caucasian, light
      Asian): Fluence: 25 J/cm2 Skin type IV (Mediterranean, Asian, Latin): Fluence: 18 J/cm2 Skin
      type V (Light skinned black, Darker mediterranean): Fluence: 16J/cm2 Skin type VI (Dark
      skinned black): Fluence 14 J/cm2

      A spot size of 12 mm and a cryogen spray delay of 50/50 will be used for all treated
      patients. The treatment area will not exceed 15cm x 15cm. If the patient cannot tolerate
      treatment with the Alexandrite laser, the patient will be terminated from the study.
      Following each treatment session, the patient will be given an ice pack to reduce any
      discomfort the patient may experience as a result of treatment with the laser. Clinical
      evaluation and photographs will determine improvement.
    

Intervention name(s): Alexandrite Laser
Intervention type(s): Device
Intervention description(s): Alexandrite 755nm hair removal laser
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: For each patient, one side of the body will serve as the treatment side and the other side as the control
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: hidradenitis suppurativa; hidradenitis; laser
Safety and Pharmacokinetics of MMX Mesalamine in Children and Adolescents With Ulcerative Colitis
Condition: Ulcerative Colitis
MeSH terms: Colitis; Colitis, Ulcerative; Ulcer
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine the safety and pharmacokinetics of MMX mesalamine
      following administration in children and adolescents with ulcerative colitis.
    


Intervention name(s): MMX Mesalamine; MMX Mesalamine; MMX Mesalamine
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 30 mg/kg/day of MMX Mesalamine tablets, dosed once daily for 7 days.; 60 mg/kg/day of MMX Mesalamine tablets, dosed once daily for 7 days.; 100 mg/kg/day of MMX Mesalamine tablets, dosed once daily for 7 days.
Other intervention name(s): Lialda, SPD476; Lialda, SPD476; Lialda, SPD476
Intervention MeSH terms: Mesalamine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Assessing Anterior Cingulate Brain Activity in People With Late-Life Depression
Condition: Depression
MeSH terms: Depression; Depressive Disorder
Study type: Observational

Summary: 
      This study will examine differences in activity of the anterior cingulate cortex, a brain
      area involved in emotion and cognitive regulation, between older adults with and without
      depression.
    

Detailed description: 
      Older adults with depression often also suffer from executive dysfunction-problems with
      planning, impulse control, and reasoning. Executive dysfunction in older adults predicts poor
      or delayed response to antidepressant treatment and has been associated with early relapse
      and recurrence of late-life major depression. Functional magnetic resonance imaging (fMRI) is
      a scan that can measure the activity of someone's brain while that person performs tasks. So
      far, no fMRI studies investigating cerebral activation patterns in late-life depression have
      been published. In this study, people will undergo fMRI while they are performing an
      executive function task. Older adults with late-life depression and older adults without
      depression will be tested and compared in order to identify the areas and patterns of brain
      activity underlying executive dysfunction in late-life depression.

      Participation in this study will consist of one study visit, during which participants will
      undergo an fMRI scan that will last 60 to 90 minutes. While being scanned, participants will
      perform cognitive tasks that involve pressing buttons in response to words viewed on a
      screen.
    

Intervention name(s): Escitalopram
Intervention type(s): Drug
Intervention description(s): 10 to 20 mg daily as part of another study in which participants are enrolled
Other intervention name(s): Lexapro
Intervention MeSH terms: Escitalopram
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Depressed and control participants are recruited from the community, with additional
        depressed participants recruited from a geriatric outpatient clinic at New York
        Presbyterian/Weill Cornell Medical College.
      
Keywords: Geriatric Depression
The Efficacy and Safety of the 1,414 nm Nd:YAG Laser System for Alleviating Back Pain in a Lumbar Disc Patient
Condition: Lumbar Herniated Intervertebral Disc
MeSH terms: Intervertebral Disc Displacement; Back Pain
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      This study aims to evaluate the efficacy and safety of the 1,414nm Nd:YAG laser system
      (ACCUPLASTI) added to Percutaneous Epidural Neuroplasty (PEN), a conventional treatment, to
      alleviate back pain in a lumbar herniated intervertebral disc patient.
    


Intervention name(s): 1,414nm Nd:YAG Laser System
Intervention type(s): Device
Intervention description(s): It has high absorption coefficient in water and a short pulse width.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Optimization of Music Compression
Condition: Hearing Loss
MeSH terms: Hearing Loss
Study type: Interventional

Summary: 
      Hearing impaired persons suffer from inferior music perception with and without hearing aids.
      Hearing aids, however, are primarily designed to improve speech intelligibility not music
      enjoyment. This study investigates the potential benefit of signal processing strategies that
      are optimized for music. The purpose of this study is to improve music compression for
      hearing impaired people.
    


Intervention name(s): Audio signal processing (applied offline before playback)
Intervention type(s): Other
Intervention model: Single Group Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Pharmacokinetic Study of Oral ALXN1840 in Japanese and Non-Japanese Adult Healthy Participants
Condition: Wilson Disease
MeSH terms: Hepatolenticular Degeneration
Study type: Interventional
Phase: Phase 1

Summary: 
      The main purpose of the study is to confirm how long ALXN1840 stays in the body of Japanese
      and non-Japanese healthy participants (that is, pharmacokinetic [PK] profile).
    


Intervention name(s): ALXN1840
Intervention type(s): Drug
Intervention description(s): Tablet for oral use.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
A Social Media Intervention for Risky Drinking
Condition: Drinking Behavior
MeSH terms: Drinking Behavior
Study type: Interventional

Summary: 
      This study is being completed to pilot prevention methods to promote wellness and reduce
      risky behaviors, including the use of substances such as alcohol and other drugs. This study
      will help the study team learn about ways of delivering this information that is both
      appealing and helpful to young adults.
    


Intervention name(s): Social media messaging
Intervention type(s): Behavioral
Intervention description(s): A motivational interviewing-based intervention delivered via private health coaching on social media for 8 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Health Services Research
GnRH Agonist Administration in the Luteal Phase of ICSI-ET Cycles
Condition: Infertility
MeSH terms: Infertility
Study type: Interventional

Summary: 
      A single dose GnRH agonist administration in the luteal phase of assisted reproduction cycles
      was reported to increase pregnancy and birth rates. This study was done to evaluate the
      reproducibility of previous findings.
    

Detailed description: 
      GnRH agonist administration in the luteal phase was reported to beneficially affect clinical
      outcome of ICSI-ET cycles. This randomized controlled trial evaluates the effect of a single
      dose GnRH agonist administered in the luteal phase on the outcome of ICSI - ET cycles
      stimulated with the long GnRH agonist protocol. Women undergoing embryo transfer following
      controlled ovarian hyperstimulation with a long GnRH agonist protocol were included. In
      addition to routine luteal phase support with progesterone women were randomized to receive a
      single dose of GnRH agonist or placebo on the sixth day after ICSI.Ongoing pregnancy rate was
      the primary outcome measure.
    

Intervention name(s): triptorelin acetate; Na Cl %0.9
Intervention type(s): Drug; Drug
Intervention description(s): Single dose of 0.1 mg triptorelin subcutaneous injection on the 3rd day after embryo transfer; 0.1 ml sterile saline subcutaneous injection on the 3rd day after embryo transfer
Other intervention name(s): Decapeptyl Ferring GmBH Kiel Germany; Isotonik NaCl %0.09 Eczacibasi-Baxter Istanbul Turkey
Intervention MeSH terms: Triptorelin Pamoate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: GnRH agonist; IVF/ICSI outcome; luteal phase
A Rehabilitation With Virtual Reality in Patients After Hip Arthroplasty Surgery (VRRS2018)
Condition: Hip Disease
Study type: Interventional

Summary: 
      .Assessing efficacy of rehabilitation with virtual reality exercises compared to traditional
      rehabilitation in the patient's operated hip arthroplasty
    

Detailed description: 
      Randomized controlled clinical study: Comparison of clinical efficacy between rehabilitation
      with virtual reality (VRRS) and traditional physiotherapy in post-surgical rehabilitation
      treatment in hospital. Motor clinical evaluations will be carried out in both groups.

      Vrrs Arm: 32 subjects will undergo a virtual motor-reality training during the post-surgical
      rehabilitation period.

      Physiotherapist's arm: 32 subjects with demographic characteristics similar to the subjects
      of the Vrrs arm will undergo the habitual rehabilitative physiotherapy.

      According to normal clinical practice, both groups perform a co-intervention in addition to
      the assigned group; Manual therapy with exercises and functional activity (walk and stairs).
    

Intervention name(s): rehabilitation
Intervention type(s): Other
Intervention description(s): rehabilitation
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: randomized
Masking: None (Open Label)
Primary purpose: Treatment
Safety and Efficacy of Empiric Levothyroxine (LT4) Dose Increase Versus Individualized LT4 Dose Increase in Hypothyroid Women During Pregnancy
Condition: Pregnancy Related; Thyroid
MeSH terms: Hypothyroidism
Study type: Interventional

Summary: 
      In women who require thyroid hormone replacement medication, the investigators will compare 2
      ways to adjust thyroid medication during pregnancy to determine superiority in maintaining
      optimal blood levels of thyroid hormone. Thyroid hormone requirements increase significantly
      in pregnancy and it is important that blood levels of thyroid hormone remain normal so the
      fetus, which cannot make its own thyroid hormone has enough for early prenatal development.
      This trial compares 2 methods for adjusting thyroid medicine during pregnancy in women with
      known thyroid disease. Pregnant women (age 18 to 45) who take thyroid medication will be
      randomized to either 1) a 2-dose per week increase in thyroid medicine once pregnancy is
      confirmed, followed by dose adjustments every 2-4 weeks, or 2) adjustments in thyroid
      medication every 2-4 weeks in micrograms per day based on results of blood tests. The
      investigators will compare thyroid hormone levels throughout pregnancy between the groups of
      mothers to determine which method is superior in meeting the increased thyroid hormone
      requirements during pregnancy.
    


Intervention name(s): levothyroxine
Intervention type(s): Drug
Intervention description(s): To compare two different methods of adjusting thyroid hormone replacement during pregnancy to maintain TSH within the normal reference range for pregnancy.
Other intervention name(s): Synthroid; Levoxyl
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Thyroid Stimulating Hormone
Patient Navigation for Lung Cancer Screening in an Urban Safety-Net System
Condition: Non-Small Cell Lung Carcinoma; Compliance Behavior; Prevention Harmful Effects
MeSH terms: Carcinoma, Non-Small-Cell Lung
Study type: Interventional

Summary: 
      The study proposes to evaluate a patient navigation intervention among a sample of 446
      individuals referred for CT-based lung cancer screening in an urban safety-net setting.
    

Detailed description: 
      Widespread implementation of CT-based lung cancer screening is underway, but its impact on
      cancer morbidity and mortality can only be achieved IF people are screened at appropriate
      intervals and abnormal findings are appropriately assessed. The degree to which individuals,
      especially those from medically underserved populations with highest lung cancer risks, will
      adhere to the complex, multi-step process of CT-based lung cancer screening has emerged as a
      key question with immediate need for solution. Specific aims of the study are as follows:

        -  Aim 1: Compare rates of completion for clinically recommended steps in the lung cancer
           screening process between patients referred for CT-based lung cancer screening who are
           randomized to the navigation intervention versus patients who receive usual care.

        -  Aim 2: Compare changes in patient-reported outcomes, including satisfaction with care,
           psychosocial distress, and tobacco use between patients in the navigation intervention
           versus those who receive usual care for the CT-based lung cancer screening process.

        -  Aim 3 (Exploratory): Explore whether differences seen in Aims 1 and 2 are moderated
           theory-based patient attitudes and beliefs (perceived susceptibility, severity of lung
           cancer, perceived benefits/barriers to screening, self-efficacy).

      This study will offer unprecedented insight into implementation of lung cancer screening for
      high-risk individuals in underserved settings. Findings will show whether navigation
      interventions increase adherence to the screening process and affect patient-reported
      outcomes among underserved populations. The proposed program aims to address these issues for
      lung cancer screening at its inception, rather than after disparities in screening uptake
      have already emerged.
    

Intervention name(s): Patient Navigation
Intervention type(s): Behavioral
Intervention description(s): Patient navigated reminder calls containing information about screening appointments, reminders, hints to facilitate communication with physicians, and smoking cessation.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Screening
The Volume Effect of Hydrodissection for Carpal Tunnel Syndrome
Condition: Carpal Tunnel Syndrome
MeSH terms: Carpal Tunnel Syndrome; Syndrome
Study type: Interventional

Summary: 
      The investigators investigated the volume effect of hydrodissection for Injection therapies
      in patients with Carpal Tunnel Syndrome. The investigators evaluated participants by Shear
      Wave Ultrasound Elastography and Artificial Intelligence Imaging Analysis
    

Detailed description: 
      The investigators investigated the volume effect of hydrodissection for Injection therapies
      in patients with Carpal Tunnel Syndrome. The investigators evaluated participants by Shear
      Wave Ultrasound Elastography and Artificial Intelligence Imaging Analysis
    

Intervention name(s): Dextrose 1mL injection; Dextrose 2mL injection; Dextrose 4mL injection
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): Dextrose 1mL injection and hydrodissection for CTS; Dextrose 2mL injection; Dextrose 4mL injection
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Regulatory T-cells in Psoriasis Patients as Targets for Therapy
Condition: Psoriasis
MeSH terms: Psoriasis
Study type: Observational

Summary: 
      The aim of this study is to understand which therapies will suppress effector cells and
      promote regulatory T cells and To test whether patients with a better response to therapy and
      longer psoriasis-free periods develop a higher numerical ratio of regulatory to effectors
      T-cells and/or regulatory cells more able to suppress the effectors.
    

Detailed description: 
      This is an observational study for the effect of different treatment options of psorisis on
      regulatory T-cells. Patients in whom a decision to treat with one of the following therapies
      (Dovobet, neotigason, narrow-band UVB and anti TNF alpha therapy) and agreed to take part in
      the study will be selected. Allocation of different treatments to patients is not part of the
      study. We will enroll 40 patients with moderate to severe psoriasis in the age range from 18
      to 70. patients must be treatment-free for at least 2 weeks for topical application and 4
      weeks for systemic treatment of psoriasis. females of child bearing potential must be on
      reliable contraception. Children below 18 years, patients above 70 years, pregnant and
      lactating patients and immunosuppressed patients are excluded from this study. Blood and
      tissue samples will be taken before and after treatment. We will also invite 10 patients who
      are receiving ellipse excisions of naevi, and who known not to have psoriasis, to provide
      control samples of distal skin beyond the margins required to demonstrate complete removal
      and control donation of blood.
    

Intervention name(s): Dovobet, neotigason, etanercept, adalimumab. infliximab
Intervention type(s): Drug
Intervention description(s): Dovobet ointment 15g/day for 6 weeks Neotigason capsule 50mg per day (oral) for 6 weeks Enbrel 50mg twice weekly subcutaneous injection for 6 weeks Humira 80mg week 0, 40 mg week 1 then every other week therafter subcutaneous injection for 6 weeks Remicade 3 separate doses of 5mg/kg intavenous injection for 6 weeks
Intervention MeSH terms: Adalimumab; Infliximab; Etanercept; Acitretin
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients and control in this study will be identified and recruited from the department of
        Dermatology by clinical members of the study team.
      
Biospecimen description: 
      Whole Blood Skin biopsy
    
Keywords: Regulatory T-cells, psoriasis, IL-10.