Epidemiological Study on the Relationship Between Respiratory Health and Air Pollution From Industrial Sources
Condition: Airway Obstruction; Hypertension; Diabetes Mellitus; Dyslipidemias; Pulmonary Disease, Chronic Obstructive
MeSH terms: Pulmonary Disease, Chronic Obstructive; Airway Obstruction; Dyslipidemias
Study type: Observational

Summary: 
      The ELISABET STUDY is across sectional Survey on a representative sample of two urban area
      conduct on a representative sample. The main objective of the project is to compare the
      prevalence of the obstructive ventilatory disorders (OVD) in the Urban Community of Dunkirk
      touched by the industrial pollution in relation to the one recovered in the Urban Community
      of Lille (CUDL) less industrialized.
    

Detailed description: 
      Airflow obstruction include Pulmonary Disease, Chronic Obstruction and asthma. Identification
      of Airflow obstruction is through Functional Tests Lung. In the 1950s, high pollution levels
      were associated with increased mortality. Despite a reduction of air pollution, it has been
      established that pollution peaks have short-term effects on acute respiratory episodes. The
      Urban Community of Dunkirk (CUD) focuses many large pollutant emitters. The long term effects
      of industrial pollution on TVO are unknown.

      The main objective of the project is to compare the prevalence of Airflow obstruction in the
      Urban Community of Dunkirk affected by industrial pollution compared to that found in the
      Urban Community of Lille (CUDL) less industrialized. Secondary objectives are: 1) To assess
      the relationship between air pollution from industrial and biological markers, particularly
      the plasma concentrations of heavy metals 2) To assess the prevalence of TVO general
      population in French populations 3) Establish a baseline epidemiological and biological bank.
    

Intervention name(s): heteroevaluation scale by a nurse or doctor
Intervention type(s): Other
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        The participants were selected from electoral rolls by random sampling, with stratification
        for gender, age and centercentre (Lille or Dunkirk). All participants were all recruited
        between January 2011 and November 2013. Each selected participant received a letter asking
        him/her to contact the coordinating team and make an appointment for data collection. In
        the absence of a reply, participants were contacted by telephone. Data was collected at
        home (occasionally during a consultation in a healthcare establishment). In all cases, a
        trained, registered nurse administered a detailed questionnaire and performed spirometry
        testing.
      
Biospecimen description: 
      -  A 2 ml aliquot of heparinized plasma stored at -20 ° C

        -  Five 0.5 ml aliquots of EDTA plasma stored at -80 ° C

        -  Two 1-ml aliquots of EDTA blood stored at -80 ° C

        -  An aliquot of 10 ml and three aliquots of 5 ml of urine stored at -80 ° C

        -  Two locks of hair preserved in an envelope at room temperature

        -  Six 0.250 ml aliquots of condensate stored at -80 ° C

        -  DNA extraction.
    
Keywords: air pollution; epidemiological survey; representative sample