Aerobic Exercise Training in Mild Cognitive Impairment Study
Condition: Mild Cognitive Impairment
MeSH terms: Cognitive Dysfunction
Study type: Interventional

Summary: 
      This study is being done to find out whether regulation of brain blood flow is altered in
      patents with mild cognitive impairment (those who have memory problems but otherwise healthy)
      when compared with healthy elderly individuals. In addition, this study will determine
      whether exercise training improves brain blood flow, brain structure, and brain function in
      patients with mild cognitive impairment (MCI).

      This is a research study because at present the investigators know little about brain blood
      flow regulation in patients with mild cognitive impairment. The investigators also know
      little about whether exercise training improves brain blood flow, brain structure, and brain
      function in patients with mild cognitive impairment.
    

Detailed description: 
      We plan to study 70 patients with amnestic MCI and 30 healthy older adults with similar age,
      sex, and educational level in this research at the University of Texas Southwestern(UTSW)
      Medical Center Dallas and Texas Health Presbyterian Hospital Dallas - Institute for Exercise
      an Environmental Medicine (IEEM).

      To help decide if you qualify to be in this study, the researchers may ask you questions
      about your health, including medications you take and any surgical procedures you have had.
      You may also have to fill out certain forms or have the following exams, tests or procedures.
      The screening process usually takes 2-3 hours.

      You will be required to come for 7-9 visits including the initial screening for eligibility
      to participate in this study. The experiments will measure your brain perfusion, vascular
      function and exercise capacity.

      For the healthy controls, the expected length of this study will be about 2-3 months
      including all the test visits. Your participation in this study will end following completion
      of your testing.

      For those with Mild Cognitive Impairment, the expected length of this study will be about 18
      months including all the test visits and exercise training. Your participation in this study
      will end following completion of your repeat testing after one-year exercise training or
      control intervention. On occasion, training may be delayed due to injury, illness or personal
      matters. If this is the case, your enrollment in the study may last longer than one year as
      we attempt to complete the training and testing.
    

Intervention name(s): Exercise; Balance training
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Patients with mild cognitive impairment will undergo moderate intensity endurance exercise training for one year.; A group of patients with mild cognitive impairment will perform flexibility and balance training for one year as a control group.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: Mild Cognitive Impairment; Exercise