The Effect of Nordic Recommended Diet on the Features of Metabolic Syndrome - Multicentre Study
Condition: Abdominal Obesity; Insulin Resistance; Impaired Glucose Tolerance; Type 2 Diabetes; Cardiovascular Diseases
MeSH terms: Cardiovascular Diseases; Metabolic Syndrome; Insulin Resistance; Glucose Intolerance; Obesity, Abdominal; Syndrome
Study type: Interventional

Summary: 
      SYSDIET (Systems biology in controlled dietary interventions and cohort studies) is one of
      the three centres in the NCoE Food, Nutrition and Health, 2007-2011. It consists of 12
      partners from five Nordic countries working on multidisciplinary fields of science related to
      nutritional biology. The main objective of SYSDIET is to reveal mechanisms by which Nordic
      foods and diets could be modified to promote health and prevent insulin resistance, type 2
      diabetes and cardiovascular diseases, all of which being connected to metabolic syndrome.
      Furthermore, the aim is to build up a Nordic platform for cohort studies and carefully
      conducted multi-centre dietary intervention studies, where novel nutritional systems biology
      tools can be applied besides human studies also in animal and cell culture studies. In order
      to achieve the main objective a Nordic multi-centre randomized controlled human intervention
      study is being conducted in 2009-2010 in 6-8 centres of SYSDIET consortium.

      Health of the Nordic populations has substantially improved during the last 30 years. This is
      due e.g. to marked decline in cardiovascular morbidity and mortality. However, during the
      last 10-20 years increasing obesity and sedentary lifestyle have resulted in an increase of
      metabolic syndrome and type 2 diabetes.

      Having this background, the aim of the SYSDIET consortium is to carry out a controlled,
      randomized dietary intervention study in persons with features of metabolic syndrome to find
      out the effects of a healthy Nordic food on major abnormalities in metabolic syndrome.

      Altogether 167 persons aged 30 to 65 years were recruited from 6-8 centers (40-60
      subjects/center) of the SYSDIET cohort. The main inclusion criterion is BMI 27-38 kg/m2. The
      subjects should also have at least two other IDF criteria for metabolic syndrome. Recruited
      persons will start the study by following their conventional diet for one month as a run-in
      period. After that subjects will be randomly assigned into Experimental- or
      Control-diet-group for 6 months. Experimental diet is rich in whole grain products, berries,
      fruits, vegetables and fish, and its fat intake is modified according to current Nordic
      recommendations. Control diet is based on the current information of the mean dietary intake
      and food consumption. The diets will be realized according to eating habits in each Nordic
      country.
    

Detailed description: 
      Substudy of the multicentre SYSDIET-study has been conducted in one of the centres, Aarhus,
      Denmark.

      This study aims was determine if a "Healthy Nordic Diet (HND)" fulfilling the Nordic
      Nutrition Recommendations does affect 24-h ambulatory BP in subjects with features of
      Metabolic Syndrome. Of the 167 SYSDIET subjects with MeS, 37 were enrolled in a Danish sub
      study on 24-h ambulatory BP performed at 0 and 12 wks after randomization. 32 completed the
      sub study. All maintained stable body weight, physical activity level, medicine, and alcohol
      habits during the intervention, as prescribed.
    

Intervention name(s): Experimental diet; Control diet
Intervention type(s): Other; Other
Intervention description(s): Diet based on Nordic recommendations: rich in whole grain products, berries, fruits and vegetables, recommended fat quality. Realised based on eating habits of each Nordic country.; Diet based on the information of the current dietary intake and food consumption in Nordic countries.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Systems biology; Nutrition; Nordic diet; Dietary recommendations; Metabolic syndrome; Features of metabolic syndrome