bioihbjkbjnl/mcl2 huggingface dataset:
Ultrasound-Assisted Paravertebral Block v. Traditional Paravertebral Block For Pain Control
Condition: Paravertebral Peripheral Nerve Block; Acute Pain Management
MeSH terms: Acute Pain
Study type: Interventional

Summary: 
      The overall purpose of this research study is to compare the effectiveness of ultrasound
      assisted paravertebral block placement versus traditional "blind" technique for postoperative
      analgesia following thoracotomy or visually assisted thoracoscopic surgery.
    

Detailed description: 
      The purpose of this project is to determine if there is a difference between paravertebral
      block performed with ultrasound assistance and paravertebral block performed with traditional
      technique in terms of twenty - four hour hydromorphone (dilaudid) consumption and visual
      analogue pain scores at rest or with deep breathing at twenty - four hours. This study will
      determine if ultrasound technique used for placement of paravertebral catheter facilitates
      safety of paravertebral catheterization and improves therapeutic effect of paravertebral
      blockade for pain control after thoracotomy. The investigators will also examine if
      ultrasound assisted paravertebral blockade improves pulmonary status in post-thoracotomy
      patient.
    

Intervention name(s): Thoracotomy; Video-Assisted Thoracoscopic Surgery (VATS)
Intervention type(s): Procedure; Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Peripheral nerve block; Ultrasound guidance; Postoperative pain management post status thoracotomy; Postoperative pain management post status VATS
Comparison Study: Ligasure Versus Conventional Hemorrhoidectomy in III and IV Degree Hemorrhoids.
Condition: Hemorrhoidectomy; Hemorrhoids Third Degree; Hemorrhoids Fourth Degree; Operative Time; Pain, Postoperative; Wound Healing; Return to Work
MeSH terms: Hemorrhoids; Pain, Postoperative
Study type: Interventional

Summary: 
      A comparison study was performed between Ligasure and Milligan morgan hemorrhoidectomy to
      find out the outcome between these two techniques in 3rd and 4th degree hemorrhoids.This
      advance vessel sealing device is used to seal the pedicle of the vessel and does not burn the
      surrounding tissues , so the outcome was monitored in terms of operative time, post operative
      pain pain, duration of wound healing in 3 weeks and return to normal activities
    

Detailed description: 
      INTRODUCTION:

      Milligan Morgan hemorrhoidectomy is conventional procedure in 3rd and 4th degree hemorrhoids
      but recent advances in ligasure hemorrhoidectomy have shown to produce favorable results.
      Comparison of these two is studied in terms of pain outcome as patient perceives, operative
      time, wound healing and return to normal activities.

      OBJECTIVES:

      To compare the outcome of ligasure hemorrhoidectomy with conventional hemorrhoidectomy in III
      and IV degree hemorrhoids.

      STUDY DESIGN:

      Randomized controlled trial

      STUDY SETTING:

      The study was conducted in surgical unit 1, Services hospital, Lahore.

      DURATION OF STUDY:

      Study was completed in six months after the approval of synopsis i.e. from 1st April 2014 to
      30th September 2014.

      DATA COLLECTION PROCEDURE:

      After approval from hospital ethical committee, 100 patients fulfilling the inclusion
      criteria has been recruited from outdoor and emergency department. A detailed history had
      been taken including demographic data (age, address) and all patients had been clinically
      examined .Patients was divided in two groups randomly using random number tables. Group A:
      Conventional hemorrhoidectomy. Group B: Ligasure hemorrhoidectomy. Patients had been
      requested to sign an informed consent. They had been assured regarding confidentiality and
      expertise used for the procedure. All procedures have been performed by a single surgical
      operating team to control bias. Preoperatively operative time was noted. Post operatively
      pain had been assessed after 6 hours, 24 hours, and 48 hours, wound has been assessed in 2nd
      and 3rd postoperative week to assess epithelization and return to normal activities in days.
      All data had been collected and recorded on the Proforma
    

Intervention name(s): Hemorrhoidectomy
Intervention type(s): Procedure
Intervention description(s): excision of 3rd and 4th degree hemorrhoids
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Covidien 5mm ligasure
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Visual Analogue pain score; conventional Hemorrhoidectomy; Ligasure Hemorrhoidectomy
Safety and Efficacy of Nicardipine for the Control of Blood Pressure After SAH
Condition: Subarachnoid Hemorrhage; Intracerebral Hemorrhage
MeSH terms: Subarachnoid Hemorrhage; Cerebral Hemorrhage; Hemorrhage
Study type: Observational

Summary: 
      The purpose of this research is to explore ways to improve and simplify control of blood
      pressure in patients with SAH or ICH. This research will be done by comparing tow different
      medications that are routinely used to help control blood pressure. None of the medications
      used in this study nor any procedures performed are experimental.
    


Intervention name(s): Nicardipine and Nipride
Intervention type(s): Drug
Intervention MeSH terms: Nicardipine
Observational model: Defined Population
Time perspective: Prospective
Keywords: Patients with SAH or ICH
HIV Treatment-Readiness Measure (HTRM) Validation
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Observational

Summary: 
      The goal of this study is to assess the reliability of the HIV

      Treatment Readiness Measure (HTRM) to assist clinicians in:

      (1) determining whether or not youth living with HIV are ready to initiate HAART and (2)
      identifying youth who may be in need of additional support services to facilitate their
      adherence to HAART. The current study will examine the psychometric properties of the HTRM
      and establish its test-retest reliability over a two week period. If the HTRM is found to be
      reliable, a subsequent study will examine its predictive validity.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        HIV-infected, English speaking youth between 13 and 24 years of age who are enrolled in
        care at an AMTU or collaborating site, not currently on HAART but planning to initiate
        HAART within the next two months.
      
Keywords: HIV Treatment Readiness Measure (HTRM); Highly Active Antiretroviral Treatment (HAART); Adherence; Treatment readiness; HIV
Study to Assess Efficacy and Safety of Aclidinium Bromide and Aclidinium Bromide/Formoterol Fumarate in Stabile COPD Patients
Condition: COPD
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a multiple dose, randomised, parallel, double blind, double dummy, multicentre and
      multinational Phase III study to determine the efficacy and safety of Aclidinium
      bromide/Formoterol fumarate compared with individual components and placebo and Aclidinium
      bromide compared with Placebo when administered to patients with stable Chronic Obstructive
      Pulmonary Disease (COPD).
    


Intervention name(s): Aclidinium bromide/formoterol Fixed-Dose Combination; Aclidinium bromide; Formoterol Fumarate; Placebo
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Inhaled Aclidinium bromide/formoterol Fixed-Dose Combination, twice per day via Genuair; Inhaled Aclidinium bromide 400 μg, twice per day via Genuair; Inhaled Formoterol Fumarate 12 μg, twice per day via Turbuhaler; Inhaled dose-matched placebo, twice per day via Genuair or via Turbuhaler
Intervention MeSH terms: Bromides; Formoterol Fumarate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Dexmedetomidine in Different Dose Levels as Adjuvant to Bupivacaine-induced Ultrasound-guided Femoral Nerve Block.
Condition: Dexmedetomidine; Femoral Nerve Block; Arthroscopic Knee Surgery
Study type: Interventional
Phase: Phase 4

Summary: 
      The duration of sensory block after single dose of long acting local anesthetics is not
      sufficient to avoid the postoperative use of opioids. Alpha-2 adrenoceptor agonists such as
      clonidine have been shown to increase the duration of peripheral nerve block. Dexmedetomidine
      is a more potent and selective α-2-adrenoceptor compared to clonidine. To the best of our
      knowledge, the use of Dexmedetomidine in different dose levels as adjuvant to local
      anesthetic was not previously reported for femoral nerve block.
    


Intervention name(s): peri-neural dexmedetomidine as adjuvant to bupivacaine in femoral nerve block; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): ultrasound guided femoral nerve block with injection of 25 ml bupivacaine 0.5% perineurally with 1 ml dexmedetomidine 25, 50, or 75 microgram perineurally.
After adequate assessment of femoral nerve block, patients will be transferred to the operating room to receive a standard general anesthesia.
Intervention MeSH terms: Dexmedetomidine; Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: femoral nerve block; peri-neural dexmedetomidine
Activity To Improve Outcomes in Peripheral Arterial Disease
Condition: Peripheral Arterial Occlusive Disease
MeSH terms: Peripheral Arterial Disease; Peripheral Vascular Diseases; Arterial Occlusive Diseases
Study type: Interventional

Summary: 
      Peripheral artery disease (PAD) results in blockages of arteries (blood vessels) in the legs
      and decreased blood flow to the legs. This may cause difficulty or pain with walking or other
      activities that use leg muscles. Exercise may help improve blood flow in the legs and improve
      the ability to walk. This research project is being implemented in adults with PAD to examine
      the effects of exercise or weight loss programs on lower extremity blood flow, health, and
      physical function.
    

Detailed description: 
      This pilot study seeks to gather data on different exercise interventions in PAD.
      Collectively, the proposed studies will gather data on the role of novel exercise
      interventions in those with PAD who are receiving conservative treatment as well as those who
      have undergone an endovascular intervention for lower extremity arterial disease.

      We hypothesize that patients who undergo an exercise intervention will: A) show improved
      lower extremity perfusion and B) improve their functional ability, compared to a standard
      care control group over 6 months of follow-up. We further hypothesize that these improvements
      are mediated through angiogenesis and increased perfusion of the lower limb, as well as
      improvements in muscle strength, mass, and function.
    

Intervention name(s): Active Exercise; Neuromuscular electrical stimulation; Weight loss and active exercise; Ad lib activity at home
Intervention type(s): Other; Other; Other; Other
Intervention description(s): Active exercise on a treadmill; Neuromuscular electrical stimulation; Weight loss and active exercise on a treadmill; Ad lib activity at home
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Peripheral arterial disease; Endovascular; Exercise; Perfusion; Functional capacity
Efficacy of Interferential Laser Therapy in Shoulder Pain
Condition: Shoulder Musculoskeletal Disorders
MeSH terms: Musculoskeletal Diseases
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine the advantages of the interferential laser therapy
      in shoulder pain reduction compared with the conventional low level laser therapy modality.
    

Detailed description: 
      The spatiotemporal superposition of two independent and opposite beams of laser generates a
      constructive interference pattern that increases the therapeutic effects in the irradiated
      tissue. Patients diagnosed of shoulder pain from different musculoskeletal disorders will
      received conventional or interferential laser therapy. This is a comparative, randomized and
      double - blind clinical study. Two identical equipments of near infrared laser therapy will
      be used. Number of sessions: 15. Frequency of the sessions: daily. Irradiation technique:
      manual, contact and punctual.Pain will be evaluated by visual analog scale (VAS) at rest and
      during analytical shoulder movements (abduction, adduction, internal rotation, external
      rotation, flexion, extension) and by means of a pain and disability index (SPADI).
      Evaluations will take place at pre and post treatment.
    

Intervention name(s): Interferential Laser therapy
Intervention type(s): Device
Intervention description(s): Two GaAlAs laser (810 nm, 100mW)were used. In the interferential laser treatment, two probes were simultaneously applied. In the conventional laser group, only one probe was switched on. Laser was applied at five points over the pain area. The laser emission mode was continuous with an energy dose of 6 joules per point and session, a power density of 1.09 w/cm2 and an irradiation time per point of 60 s. The average output power was 100 mW and the total energy dose delivered in a patient session was 30 J. Every treatment was along 15 sessions. Hence, the accumulated energy delivered on the whole was 450 Joules for the conventional group of patients (using one beam) and 900 Joules for the interferential one (using two beams).
Other intervention name(s): Interference Laser Therapy.; Device Brand Name: Laser Sys. Stim 540(Mettler Electronics).; SN: 105XLS147 (first laser) and 105XLS148 (second laser).
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Interferential laser therapy
IL-6 in Exercise-Induced Anorexia
Condition: Appetitive Behavior; Pediatric Obesity
MeSH terms: Pediatric Obesity; Anorexia
Study type: Interventional

Summary: 
      This study investigates the effect of high intensity exercise, with and without the
      inflammation inhibitor, ibuprofen, on plasma levels of IL-6 and other selective biomarkers of
      inflammation and appetite on food intake and subjective ratings of appetite in normal-weight
      boys.
    


Intervention name(s): High Intensity Exercise/Ibuprofen
Intervention type(s): Other
Intervention description(s): HIEX, with and without the inflammation inhibitor, ibuprofen, on plasma levels of IL-6 and other selective biomarkers of inflammation and appetite on food intake and subjective ratings of appetite in normal-weight boys.
Intervention MeSH terms: Ibuprofen
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Fifteen normal-weight boys (aged 13-18y) were randomly assigned in a crossover design to four sessions: 1) Water + Rest; 2) Rest + ibuprofen; 3) Water + high intensity exercise; 4) high intensity exercise + ibuprofen. High intensity exercise consisted of three 10min bouts of high intensity exercise at 75% VO2peak at 60-70RPM with 1:30min active rest interposed. IBU was given in a 300mg liquid solution. EI, visual analog scale ratings and plasma biomarkers of appetite, inflammation, stress and glucose control were measured.
Masking: Single (Participant)
Primary purpose: Basic Science
Timing of Meal Insulin Boluses for Optimal Postprandial Glycemic Control in Type 1 Diabetes
Condition: Type 1 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Interventional

Summary: 
      Blood glucose levels in patients with type 1 diabetes tend to peak after eating a meal due to
      the delayed action of insulin when compared to carbohydrate absorption from food. It is the
      hypothesis of the investigator that administering the insulin for a meal 20 minutes before
      the meal will result in lower blood glucose peaks compared to administration of insulin
      immediately before or 20 minutes after starting to eat.

      All subjects will eat the same meal on three different occasions. Insulin will be
      administered at one of the three times at each visit.
    

Detailed description: 
      Subjects enrolled in this study will be between the ages of 12 and 30 years inclusive. All
      subjects will be on an insulin pump and use carbohydrate counting as their method for insulin
      dosing at a meal.

      Subjects in this study will complete three study visits lasting from approximately 8:30am
      until 1:30pm. At each visit, the subject will eat the same frozen breakfast meal. Subjects
      will be supplied with the same insulin to maintain consistency between visits and between
      subjects.

      Insulin will be administered at different times, depending upon the randomization group
      assigned to the participant. The three different times the insulin will be given is either 20
      minutes before the meal, immediately before the meal and 20 minutes after the meal. All
      subjects will complete all three insulin bolus times. Blood glucose will be measured by
      fingerstick every 30 minutes until the completion of the visit.
    

Intervention name(s): Insulin
Intervention type(s): Other
Intervention description(s): The timing of insulin delivery varies with each study visit. The dose is given based on carbohydrate content and blood glucose level. The insulin is given either 20 minutes before the meal, immediately before the meal, or 20 minutes after the meal.
Other intervention name(s): Insulin time
Intervention MeSH terms: Insulin; Insulin, Globin Zinc
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Blood Glucose; Meal insulin
Exploratory Study of Additional Use of Scopolamine Butylbromide, Glucagon or NPO-11 Following Single Dose of NPO-11 in Healthy Adult Men
Condition: Healthy
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to evaluate the safety and efficacy of the additional
      administration of scopolamine butylbromide, glucagon or NPO-11 following a single
      intragastric dose of NPO-11 during endoscopy in healthy adult men. The safety will be
      evaluated based on adverse events and adverse drug reactions (ADRs) observed with NPO-11 +
      scopolamine butylbromide or glucagon, and following additional administration of NPO-11. The
      efficacy will be evaluated based on changes in the frequency of gastric peristalsis
      classification after the initial dose and the additional dose, and on the presence or absence
      of gastric peristalsis at each evaluation point.
    


Intervention name(s): NPO-11; NPO-11; NPO-11
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 20 mg butylscopolammonium bromide after administration of NPO-11; NPO-11 after administration of NPO-11; 1 mg glucagons after administration of NPO-11
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: During; Endoscopy; Gastric; Peristalsis
Laboratory Diagnosis and Prognosis of Severe Dengue
Condition: Dengue Fever
MeSH terms: Dengue; Severe Dengue
Study type: Observational

Summary: 
      A study of dengue in children presenting to outpatient departments of 5 large hospitals in Ho
      Chi Minh City and Tien Giang province, Viet Nam.

      Different blood tests are compared at the early stages of dengue fever onset in their ability
      to accurately and specifically detect children whose dengue will progress to severe disease.
    

Detailed description: 
      In a prospective study in the outpatients department of three large hospitals in Ho Chi Minh
      City, Viet Nam, we will determine the early diagnostic sensitivity, specificity, positive and
      negative predictive values of two NS1 diagnostic tests in severe dengue cases.

      The study is intended to develop a prognostic algorithm for the early identification of
      severe dengue cases.

      Routine demographic, haematological and biochemical laboratory markers will be utilized to
      derive a prognostic algorithm that is clinically-useful for guiding patient triage and
      interventions.

      We hope to discover and evaluate new early biomarkers of severe dengue and will evaluate
      candidate host response molecules and virological markers for their prognostic value.

      We further plan to understand the phylogeography of DENV in the super-urban setting of HCMC.

      We will use genome scale sequencing of DENV together with geospatial information on the
      residential addresses of patients to better understand transmission dynamics in space and
      time in a high transmission super-urban district of HCMC and thereby identify opportunities
      for public health interventions.
    

Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patient presenting to outpatient department of participating hospitals with symptoms of
        dengue fever
      
Keywords: Dengue fever; severe dengue fever; NS1 detection assay; Prognosis; Diagnosis
Pharmacokinetic Profile in Plasma and Epithelial Lining Fluid of Finafloxacin
Condition: Safety and Tolerability
Study type: Interventional
Phase: Phase 1

Summary: 
      This study investigates the safety, tolerability, and PK profile of finafloxacin as a novel
      fluoroquinolone and a potential therapeutic agent for lower respiratory infections such as
      bacterial pneumonia. A comparison of the PK profile of finafloxacin in plasma and lung ELF
      using different bronchoscopic ELF sampling techniques (BMS and BAL) is conducted.
    


Intervention name(s): Finafloxacin 800 mg (as 4 x 200 mg tablet) once daily for 3 days
Intervention type(s): Drug
Intervention MeSH terms: Finafloxacin
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment