Study on the Mechanism of Regulating Gut Microbiome in Obese People by Regulating Brain-gut Axis With Fast Diet
Condition: Obesity; Gastrointestinal Microbiome; Magnetic Resonance Imaging
MeSH terms: Obesity
Study type: Interventional

Summary: 
      1. Normal diet：Starting from May 20, 2018, the subjects will eat a normal diet for 4 days,
           with no restriction on calories and food types. The subjects are required to record
           their daily diet and dietary intake of calories.

        2. Fast diet of High control ：From May 24, 2018, the method of fast diet was adopted on
           alternate days. According to the dietary records of normal diet, the normal caloric
           intake of each subject was calculated. Fast diet was carried out according to 2/3, 1/2,
           1/3 and 1/4 of the original normal caloric intake.Each caloric stage last for 4 days,
           and the total cycle of fast diet was 31 days.

        3. Fast diet of Low control ：After the intervention of fast diet of high control, the
           subjects were allowed to continue the diet fast diet every other day. It was suggested
           that the daily caloric intake was 600kal/ day for males and 500kal/ day for females.
    

Detailed description: 
      1. Normal diet: the course of treatment was 4 days. The subjects were asked to record the
           daily diet and dietary intake in the daily observation scale (Table 1).

        2. High control diet intervention: the course of treatment was 31 days. According to the
           actual intake of calories, 2 / 3, 1 / 2, 1 / 3 and 1 / 4 of the actual intake of the
           subjects were calculated as the light fasting calories. The treatment course of each
           calorie stage was 4 days. The subjects recorded the daily diet and dietary intake, and
           the nutritionists calculated the daily calorie intake and dietary types of each subject
           according to the daily calorie intake of each subject's normal diet. During the period
           of high control diet intervention, the diet on the day of light fasting was provided by
           the research group. Besides the diet provided by the research group, other foods (except
           water without calories) were strictly prohibited on the day of light fasting.

        3. Low control diet intervention: the course of treatment was 31 days. It is suggested that
           the calorie intake of men and women should be 600 kcal / day and 500 kcal / day on the
           day of light fasting. The diet type can refer to the recipe made by the nutritionist.
    

Intervention name(s): Fast diet
Intervention type(s): Other
Intervention description(s): Fast diet of High control ：From May 24, 2018, the method of fast diet was adopted on alternate days. According to the dietary records of normal diet, the normal caloric intake of each subject was calculated. Fast diet was carried out according to 2/3, 1/2, 1/3 and 1/4 of the original normal caloric intake.Each caloric stage last for 4 days, and the total cycle of fast diet was 31 days.
Fast diet of Low control ：After the intervention of fast diet of high control, the subjects were allowed to continue the diet fast diet every other day. It was suggested that the daily caloric intake was 600kal/ day for males and 500kal/ day for females.
Intervention model: Single Group Assignment
Intervention model description: Normal diet：Starting from May 20, 2018, the subjects will eat a normal diet for 4 days, with no restriction on calories and food types. The subjects are required to record their daily diet and dietary intake of calories.
Fast diet of High control ：From May 24, 2018, the method of fast diet was adopted on alternate days. According to the dietary records of normal diet, the normal caloric intake of each subject was calculated. Fast diet was carried out according to 2/3, 1/2, 1/3 and 1/4 of the original normal caloric intake.Each caloric stage last for 4 days, and the total cycle of fast diet was 31 days.
Fast diet of Low control ：After the intervention of fast diet of high control, the subjects were allowed to continue the diet fast diet every other day. It was suggested that the daily caloric intake was 600kal/ day for males and 500kal/ day for females.
Masking: None (Open Label)
Primary purpose: Other
Keywords: Obesity；Gut microbiome；Task fMRI;Brain-Gut axis