bioihbjkbjnl/mcl2 huggingface dataset:
Therapeutic Ultrasound on Renal Function
Condition: Ultrasound Therapy; Complications; Low Back Pain
MeSH terms: Low Back Pain
Study type: Interventional

Summary: 
      This study evaluates whether therapeutic ultrasound (TUS) treatment applied to lumbar region
      with chronic low back pain affect renal function.
    

Detailed description: 
      Low back pain is a common problem and there are many treatments for chronic low back pain,
      including TUS. Investigators routinely observed increased blood creatinine and urea levels in
      some of patients who received TUS.

      Half of patients will receive TUS treatment for low back pain while the other half will not
      receive. The patients will be evaluated at baseline and the end of the treatment . The serum
      creatinine, serum cystatin C, 24-hour urine creatinine, creatinine clearance, 24-hour urine
      microalbumin and microprotein, urine volume, and GFR will be measured at each evaluation.
    

Intervention name(s): physiotherapy modalities
Intervention type(s): Other
Intervention description(s): The physiotherapy modalities will be applied for five sessions a week for 3 weeks.
The all patients will be treated with superficial heating (the moist heat pack will be applied to the patient's lower back for 20 minutes) , transcutaneous electrical nerve stimulation(frequency of 100 Hz, pulse duration of 100 μs, sensory-level amplitude was applied for 25 minutes) , exercise therapy (consisting of flexion, extension, stretching, mobilisation, and postural exercises performed for approximately 25 minutes ) .
In addition to these therapies, continuous therapeutic ultrasound treatment will be applied to patients in first group for 10 minutes; frequency of 1 megahertz, intensity of 1.5 W/cm2, effective irradiation area of the transducer head 5 cm2 .
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Diagnostic
Keywords: Chronic Pain; physiotherapy; renal function
Wristbot: A Novel Device for the Assessment of Proprioceptive Deficits After Stroke
Condition: Stroke
MeSH terms: Stroke
Study type: Interventional

Summary: 
      The WristBot constitutes a comprehensive, integrated robotic system for the early diagnosis
      and rehabilitation of sensory and fine motor dysfunction to neurological or orthopedic
      disease.
    

Detailed description: 
      The WristBot constitutes a comprehensive, integrated robotic system for the early diagnosis
      and rehabilitation of sensory and fine motor dysfunction to neurological or orthopedic
      disease. It has been validated in three clinical trials, including orthopaedic patients,
      Parkinsons disease and 9 chronic stroke patients. Its unique feature uses adaptive,
      progressive robot-aided therapy to achieve intensive, task specific wrist movements.

      In the context of the proposed project we will target the stroke population. Integration
      refers here to the system's ability to perform the assessment of proprioceptive status and
      proprioceptive training in a single device. The scope of the current project is investigating
      the efficacy of the proprioceptive assessment of the WristBot and correlating the result
      throughout the rehabilitation protocol. The proposed technology comprises a hardware device
      with four motors that can apply torques to the human wrist about its three degrees of freedom
      (i.e. axes of rotation: wrist flexion/extension,abduction/adduction and forearm
      pronation/supination). This allows for guided and controlled movements of the wrist by
      delivering assistive, resistive, perturbation or no forces (patient actively moves the
      wrist). It contains a set of specialized software modules that a) allow for the objective,
      psychophysical assessment of sensory dysfunction in patients, and b) provide specialized
      training modules designed to improve sensory and motor functions of the wrist.
    

Intervention name(s): Wristbot
Intervention type(s): Device
Intervention description(s): The proposed technology comprises a hardware device with four motors that can apply torques to the human wrist about its three degrees of freedom (i.e. axes of rotation: wrist flexion/extension,abduction/adduction and forearm pronation/supination). This allows for guided and controlled movements of the wrist by delivering assistive, resistive, perturbation or no forces (patient actively moves the wrist). It contains a set of specialized software modules that a) allow for the objective, psychophysical assessment of sensory dysfunction in patients, and b) provide specialized training modules designed to improve sensory and motor functions of the wrist.
Intervention model: Single Group Assignment
Intervention model description: Prospective single arm intervention
Masking: None (Open Label)
Primary purpose: Diagnostic
Observing the Curative Effect of Assisted Reproduction by TCM Multi-channel Interventional Therapy
Condition: Failure After Assisted Reproductive Technology
Study type: Interventional
Phase: Phase 2

Summary: 
      Objective: To evaluate the curative effect of TCM multi-channel interventional therapy on
      women with ART Failure; to compare the curative effect of the dual therapy and triple therapy
      on women with ART Failure; to choose the best TCM interventional therapeutic plan.

      Methods: The cases with ART Failure from West China second University Hospital of Sichuan
      University (West China Women's and Children's Hospital of Sichuan University) meeting the
      inclusion criteria were randomly divided into three groups: the dual therapy group, the
      triple therapy group and the control group, compare the natural pregnancy number, the
      condition during the period of secondary IVF-ET and the improvement of the kidney deficiency,
      liver depression and blood stasis syndrome among those three groups.
    

Detailed description: 
      Objective: To evaluate the curative effect of TCM multi-channel interventional therapy on
      women with ART Failure; to compare the curative effect of the dual therapy and triple therapy
      on women with ART Failure; to choose the best TCM interventional therapeutic plan.

      Methods: The cases with ART Failure from West China second University Hospital of Sichuan
      University (West China Women's and Children's Hospital of Sichuan University) meeting the
      inclusion criteria were randomly divided into three groups: the dual therapy group, the
      triple therapy group and the control group, compare the natural pregnancy number, the
      condition during the period of secondary IVF-ET and the improvement of the kidney deficiency,
      liver depression and blood stasis syndrome among those three groups.

      The results will show the effect of TCM multi-channel interventional therapy for patients
      with ART failure
    

Intervention name(s): The dual therapy; The triple therapy
Intervention type(s): Other; Other
Intervention description(s): TCM prescriptionⅡof cultivated emotion and assisted reproduction +auricular acupoint therapy; TCM prescriptionⅡof cultivated emotion and assisted reproduction + auricular acupoint therapy+ retention enema of TCM
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: TCM multi-channel therapy; ART failure
Phase II BGG492 Capsule Extension for Partial Epilepsy
Condition: Partial Onset Seizures
MeSH terms: Seizures
Study type: Interventional
Phase: Phase 2

Summary: 
      This long-term extension study will assess the safety, tolerability and efficacy of BGG492 as
      adjunctive treatment in patients with partial onset seizures.
    


Intervention name(s): BGG492
Intervention type(s): Drug
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Partial onset seizure; seizure frequency; nervous system diseases; central nervous system diseases; CNS; brain diseases; neurologic manifestations; adjunctive treatment; AEDs; antiepileptic drug
A Preliminary Drug Drug Interaction Study With TA-8995
Condition: Pharmacokinetic Interactions
Study type: Interventional
Phase: Phase 1

Summary: 
      A study in healthy males to look at how multiple doses of TA-8995 affect blood levels and
      rate of removal of other drugs, using single doses of digoxin and midazolam as examples, to
      see if there are any potential drug interactions that might affect patients in future
      studies. The study will examine whether co-administration of TA-8995 affects the
      pharmacokinetics of digoxin and midazolam measured by area under the curve (AUC).
    


Intervention name(s): TA-8995; Midazolam; Digoxin
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: Digoxin; Midazolam
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
The Effect of Aromatherapy Applied After Cesarean Section on Pain Intensity and Comfort Level
Condition: Cesarean Section Complications
Study type: Interventional

Summary: 
      Today, many complementary therapies such as acupuncture, reflexology, homeopathy,
      hypnotherapy, music and aromatherapy are tried in addition to medical methods to reduce pain
      and anxiety. Aromatherapy is a therapy method in which essential oils are used to protect and
      improve physical and psychological health. Oils can be applied directly to a single person or
      indirectly to people in a room by inhalation . In direct application without steam, essential
      oils can be applied by inhalation by dripping onto a cotton ball . It is stated that lavender
      aromatherapy, one of the most commonly used aromatherapies, has analgesic, antiseptic,
      sedative, antispasmodic and healing properties Ylang Ylang aromatherapy is stated analgesic,
      anti-inflammatory, antimicrobial, antiemetic,anti-tarral, carminative, sedative, antiseptic,
      spasmolytic properties. In the studies conducted, anxiety, labor pain, labor duration, and
      psychological effects of aromatherapy were examined, but no study was found in which lavender
      and chamomile essential oils were used and the effects of pain and comfort level were
      examined. The aim of this study is to determine the effect of lavender and Ylang Ylang
      essential oils in relieving pain and increasing comfort after cesarean section.
    


Intervention name(s): Ylang Ylang oil with inhalation; Lavender oil with inhalation
Intervention type(s): Other; Other
Intervention description(s): Ylang Ylang OIL WILL BE INHALED; LAVENDER OIL WILL BE INHALED
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Aromatherapy; pain; ceserean
Phytoestrogens as an Alternative to Estradiol in Ovulation Induction in PCOS
Condition: Polycystic Ovaries
MeSH terms: Polycystic Ovary Syndrome
Study type: Interventional
Phase: Phase 4

Summary: 
      Prospective study conducted on 150 women with polycystic ovarian syndrome (PCOS) were
      randomly divided into 3 groups: group I (50 women) received clomiphene citrate (CC) only 50
      mg orally every 8 hours started from cycle day 3 for 5 days, group II (50 women) received 2mg
      estradiol valerate daily from cycle day 7 - 11 in addition to CC and group III (50 women)
      received phytoestrogen (20mg of cimifuga racemosa from day 1- 12) in addition to CC.
    

Detailed description: 
      Prospective study conducted on 150 women with PCOS were randomly divided into 3 groups: group
      I (50 women) received CC only50 mg orally every 8 hours started from cycle day 3 for 5 days,
      group II (50 women) received 2mg estradiol valerate daily from cycle day 7 - 11 in addition
      to CC and group III (50 women) received phytoestrogen (20mg of cimifuga racemosa from day 1-
      12) in addition to CC.
    

Intervention name(s): phytoestrogen; estradiol valerate; clomiphene citrate
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 20mg of cimifuga racemosa from day 1- 12; 2mg from cycle day 7 to day 11; 50 mg orally every 8 hours started from cycle day 3 for 5 days
Other intervention name(s): Klimadynon; cycloprogynova; clomid
Intervention MeSH terms: Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Clomiphene; Enclomiphene; Zuclomiphene; Estradiol; Polyestradiol phosphate; Phytoestrogens
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: PCOS; Phytoestrogens; ovulation induction
Effect of Low-Magnitude, High Frequency Vibration Treatment on Femoral Shaft Fracture Healing
Condition: Fracture, Closed, Comminuted, Healing
MeSH terms: Fractures, Bone; Fractures, Closed
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      Diaphyseal long bone fractures are usually associated with high energy trauma in which
      femoral shaft fracture is one common fracture in young age group. Surgery is usually needed
      for the diaphyseal lone bone fractures and the painful conditions always hinder weight
      bearing which is important for fracture healing and functional recovery. Fracture healing in
      cortical bone is less predictable than trabecular bone because they are less active and blood
      supply is more critical. Therefore accelerating fracture healing and rehabilitation of long
      bone fracture will absolutely bring significant economic benefit to the society in term of
      hospitalization and sick leave cost.

      Low-magnitude, high-frequency vibration (LMHFV) treatment can provide systemic mechanical
      stimulation and is reported with multiple effects on musculoskeletal tissues. LMHFV can
      enhance the blood circulation and osteogenic effect in normal subjects and animals. Our
      previous clinical study also indicated that LMHFV could enhance the balancing ability and
      muscular function in normal post-menopausal women after treating whole-body vibration. For
      the fracture healing effect, an acceleration of healing by inducing callus formation and
      maturation in rat model was also reported in our previous studies.

      In this study a total of 50 unilateral closed femoral shaft fracture patients of either
      gender aged 20-40 years old will be recruited and they will be randomized to either control
      and vibration group. The vibration group will be treated with LMHFV for 6 months. The
      findings of this study will provide very useful scientific data to support the application of
      LMHFV for fracture healing.
    


Intervention name(s): vibration platform provide low magnitude and high frequency vibration treatment, which is self-developed by our research team
Intervention type(s): Procedure
Intervention description(s): Stand on a vibration platform at 35Hz, 0.3g, 20mins/day and 5days/week
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Vibration treatment; Fracture healing; Muscular function
Translating 3-Step Workout for Life in a Local Senior Living Community
Condition: Frail Elderly; Muscle Weakness
MeSH terms: Muscle Weakness
Study type: Interventional

Summary: 
      The study evaluates the feasibility of a staff-lead workout program, 3-Step Workout for Life,
      in a local senior living community. Eligible participants will complete assessments before
      and after the workout program.
    

Detailed description: 
      The 3-Step Workout for Life program is designed to help older adults improve muscle strength
      and apply the improved muscle strength to perform activities of daily living. The 10-week
      workout consists of single-joint resistance exercise, multiple-joint resistance exercise, and
      activities of daily living exercise. Participants will exercise in small groups in a
      community room as well as one-on-one with the fitness staff in their home. The community
      fitness staff will learn the 3-Step Workout for Life program from the University partner and
      deliver the program.
    

Intervention name(s): 3-Step Workout for Life
Intervention type(s): Behavioral
Intervention description(s): a 10-week moderate exercise program
Intervention model: Single Group Assignment
Intervention model description: Single group with pretest and posttest
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Occupational Therapy; Aging in place; Activities of daily living; Community program
Data on Oral Contraceptives Compliance in Non Stop Regimen
Condition: Contraception
Study type: Observational

Summary: 
      Adherence to the dosing scheme is the principal element of COC efficiency. On the other hand
      noncompliance seemed to be an inseparable element of any oral treatment. The aim of the study
      is to evaluate in everyday practice the relation between dosage errors and indicated factors,
      potentially influencing the compliance with the dosing scheme.
    


Intervention name(s): Qlaira or Yaz (BSP products defined as Combined Oral Contraceptive) and Cerazette or Azalia (competitor's products defined as Progestogen Only Pill)
Intervention type(s): Drug
Intervention description(s): One tablet per day, orally, 28 tablets per cycle, during three consecutive cycles.
Intervention MeSH terms: Contraceptive Agents; Desogestrel; Contraceptives, Oral; Contraceptives, Oral, Combined; Progestins
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Gynecological practices ptients - starters or current users.
      
Keywords: Contraception; Compliance
Stroke Team Remote Evaluation Using a Digital Observation Camera- Long Term Outcomes(STRokE DOC-LTO)
Condition: Telemedicine Evaluation vs Telephone Evaluation
MeSH terms: Stroke
Study type: Observational

Summary: 
      SPECIFIC AIM: The specific aims of this study are to evaluate the long term outcomes of
      patients previously enrolled in the STRokE DOC ("STRokE DOC Trial (NCT00283868)")
      telemedicine clinical trial.

      AIM 1: Aim 1 is a non- randomized, retrospective, data collection study assessing long term
      patient outcomes of patients previously enrolled in a telemedicine vs. telephone clinical
      trial (STRokE DOC Trial ("STRokE DOC Trial (NCT00283868)"); now completed). STRokE DOC-LTO
      will evaluate, (only for those patients previously enrolled in the original telemedicine vs.
      telephone clinical research trial), the long term patient outcomes; comparing telemedicine
      versus telephone-only consultations.
    

Detailed description: 
      SPECIFIC AIM: The specific aims of this study are to evaluate the long term outcomes of
      patients previously enrolled in the STRokE DOC ("STRokE DOC Trial (NCT00283868)")
      telemedicine clinical trial.

      AIM 1: Aim 1 is a non- randomized, retrospective, data collection study assessing long term
      patient outcomes of patients previously enrolled in a telemedicine vs. telephone clinical
      trial (STRokE DOC Trial ("STRokE DOC Trial (NCT00283868)"); now completed). STRokE DOC-LTO
      will evaluate, (only for those patients previously enrolled in the original telemedicine vs.
      telephone clinical research trial), the long term patient outcomes; comparing telemedicine
      versus telephone-only consultations.

      Specific Protocol Information: The protocol will contact these patients by telephone. One of
      5 Stroke Center team members will contact the patient, using strict telephone scripted
      language (approved by the IRB) and ask questions regarding

        1. current functional status

        2. death

        3. Hemorrhage

        4. Recurrent Stroke

        5. Disposition for 3 time periods (6 months after index event, 12 months after index event,
           and "current" time of contact.
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Inclusion Criteria are:

          1. Male or female subjects, age > 18 years.

          2. Prior enrollment into the STRokE DOC ("STRokE DOC Trial (NCT00283868)") clinical
             research trial.
      
Keywords: telemedicine; telephone; outcomes
Effectiveness of a Community-based Multi-modal Tai Chi Rehabilitation Program for Patients After Total Knee Arthroplasty
Condition: Total Knee Arthroplasty
Study type: Interventional

Summary: 
      The rate of falls in patients after total knee arthroplasty (TKA) is high and related to
      lower limb muscle weakness and poor balance control. However, since routine post-TKA
      rehabilitation is uncommon, it is paramount to explore alternative strategies to enhance
      balance and physical functioning in post-TKA patients. As Tai Chi is a proven strategy for
      improving balance in older people, the proposed study aims to determine the feasibility and
      acceptability of a 12-week community-based post-TKA multimodal Tai Chi program and to collect
      preliminary data with respect to the efficacy of such a program in improving balance and
      physical functioning in post-TKA patients as compared to usual postoperative care.
    

Detailed description: 
      This is a single-blinded 2-arm RCT. TKA participants will be randomized to either a 12-week
      community-based rehabilitation program starting at 12 weeks after TKA, or usual
      post-operative care without outpatient physiotherapy. A third group of asymptomatic controls
      will be recruited to provide comparisons at various time points. All post-TKA participants
      will undergo five clinical assessments: 1 week before TKA, and at 6, 12, 24 and 52 weeks
      after TKA. The untreated asymptomatic controls will be assessed at baseline, and 12 and 52
      weeks from baseline
    

Intervention name(s): 12-week community-based multi-model Tai Chi rehabilitation program; Usual post-operative care; Untreated asymptomatic controls
Intervention type(s): Other; Other; Other
Intervention description(s): Participants will receive 12 x 90 minute sessions of supervised exercises over 12 weeks. In addition to usual care, supervised exercise will be held at the Center of Sports Training and Rehabilitation inside the University and each class will be restricted to no more than 8 participants to ensure sufficient personalized attention. Each training session involves warm-up together with stretching of lower extremity muscles, strengthening exercises of the major lower extremity muscle groups by Theraband, balancing exercise, Tai Chi training, and rest/ cool-down. All lower-extremity exercises will be performed bilaterally.; No intervention will be provided; No intervention will be provided
Other intervention name(s): Fall prevention program
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: Tai Chi; Lower limb muscle strength; Balance; Rehabilitation; Multi-faceted intervention