Fatigue Reduction Diet in Lymphoma Survivors
Condition: Lymphoma, Large B-Cell, Diffuse; Fatigue
MeSH terms: Lymphoma; Lymphoma, Large B-Cell, Diffuse; Fatigue
Study type: Interventional

Summary: 
      The purpose of this small preliminary study is to gather preliminary data to support a large
      randomized controlled trial of a fatigue reduction diet intervention among diffuse-large
      B-cell lymphoma (DLBCL) survivors. This study will provide nutritional counseling to 10 adult
      patients (18 years or older) with DLBCL who have completed their upfront chemotherapy
      treatment and remained in remission for 2 years prior to enrollment. The study will employ
      individualized dietary counseling, provided by a registered dietitian (RD), by phone or video
      teleconferencing in 8 sessions over 3 months. Dietary intake and fatigue will be assessed at
      baseline and 3 months. The objective of the study is to determine feasibility of the
      intervention and adherence to the fatigue reduction diet. Data obtained from this preliminary
      study would be used to support a well-powered future randomized trial of FRD vs regular diet
      in survivors of DLBCL.
    

Detailed description: 
      Fatigue is highly prevalent in survivors of diffuse-large B-cell lymphoma (DLBCL). Fatigue
      has been linked to chronic inflammation, and diets high in antioxidant nutrients (diet rich
      in fruit, vegetables, whole grains, and omega-3 fatty acid-rich foods) have been associated
      with lesser prevalence and severity of fatigue. Studies are needed, however, to test if
      antioxidant-rich diets could improve fatigue in this patient population. This
      fatigue-reducing diet (FRD) was shown to improve fatigue and sleep in breast cancer survivors
      compared to regular diet. This FRD diet aligns with the standard of care dietary
      recommendations for cancer survivors promoted by the American Cancer Society (ACS) . The
      purpose of this small preliminary study is to gather preliminary data to support a large
      randomized controlled trial. This study will provide nutritional counseling to 10 adult
      patients (18 years or older) with DLBCL who have completed their upfront chemotherapy
      treatment and remained in remission for 2 years prior to enrollment. The study will employ
      individualized dietary counseling, provided by a registered dietitian (RD), by phone or video
      teleconferencing. Phone counseling will be weekly for the first month, and then biweekly for
      the next two months, for a total of 8 phone sessions. Counseling sessions take ~15-30
      minutes. Dietary intake will be assessed using an electronic food frequency questionnaire at
      baseline and 3 months. Fatigue will be assessed using an online survey at baseline and 3
      months. The purpose of the study to ascertain the percentage of patients who are able to
      complete all the study questionnaires and visits and adhere to the fatigue reduction diet.
      Data obtained from this preliminary study would be used to support a well-powered future
      randomized trial of FRD vs regular diet in survivors of DLBCL.
    

Intervention name(s): Fatigue Reduction Diet
Intervention type(s): Other
Intervention description(s): Participants receive individualized nutrition counseling to adopt the fatigue reduction diet protocol.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: fatigue reduction diet