bioihbjkbjnl/mcl2 huggingface dataset:
The Use of Portland Cement in Primary Anterior Teeth Pulpotomy.
Condition: Pulpotomies
Study type: Interventional

Summary: 
      - The aim of this study is to evaluate the effectiveness of White Portland cement and MTA in
      primary anterior teeth pulpotomy and follow up after 3 , 6 , 12 months ( Clinically and
      Radiographically) : Group A ( Control group ) : primary anterior teeth pulpotomized by White
      MTA . Group B : primary anterior teeth pulpotomized by White Portland Cement .

      - The aim of this study is to evaluate the effectiveness of White Portland cement and MTA in
      pulpotomy primary canines for serial extraction and extract them after 3 months for
      Histopathlogic study : Group A ( Control group ) : primary canines pulpotomized by White MTA
      . Group B : primary canines pulpotomized by White Portland Cement .
    

Detailed description: 
      -  Endodontic therapy for primary teeth faces several difficulties including morphology of
           root canals , physiological root absorption and failure to find ideal root-filling paste
           absorbs the same degree of root absorption .

        -  Pulpotomy therapy is considered easy , fast and does not include the length of canal or
           periapical region .

        -  The split mouth design will be adopted for the treated samples .

        -  Clinical success criteria :

             1. Absence of spontaneous or stimulant pain

             2. Absence gingival redness , swelling or fistula

             3. Physiological tooth mobility and absence sensitivity to percussion

        -  Radiographically success criteria :

             1. Absence periapical translucence

             2. Absence external or internal abnormal absorption
    

Intervention name(s): Pulpotomy therapy by White Portland Cement; Pulpotomy therapy by White MTA
Intervention type(s): Other; Other
Intervention description(s): Carious asymptomatic primary anterior teeth will be removed of dental caries likely to produce vital pulp exposure . The access will be refined using a sterile no. 4 or 6 round bur in a slow-speed handpiece . The remaining pulp will be treated using pulpotomy therapy by White Portland Cement; Carious asymptomatic primary anterior teeth will be removed of dental caries likely to produce vital pulp exposure . The access will be refined usinga sterile no. 4 or 6 round bur in a slow-speed handpiece . The remaining pulp will be treated using pulpotomy therapy by White MTA
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Split mouth design
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Pulpotomy; Portland cement; Primary Anterior Teeth
Single Ascending Dose Study of Intravenous Infusion of PF 07304814 in Healthy Adult Participants
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The current study is the second clinical administration with PF-07304814, the phosphate
      prodrug of the active moiety PF-00835231, and the first in healthy adult participants. It is
      to evaluate safety, tolerability and PK of single escalating doses of PF 07304814 given as a
      24-h IV infusion.
    

Detailed description: 
      The current study is the second clinical administration with PF-07304814, the phosphate
      prodrug of the active moiety PF-00835231, and the first in healthy adult participants. It is
      to evaluate safety, tolerability and PK of single escalating doses of PF 07304814 given as a
      24-h IV infusion. This is a randomized, double-blind, sponsor-open, placebo-controlled trial.
      There will be 2 cohorts with a total of approximately 16 participants planned (approximately
      8 participants in each cohort).
    

Intervention name(s): PF-07304814; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Participants will receive PF-07304814; Participants will recieve placebo
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Basic Science
Keywords: SAD, Healthy
Cyberknife for Early Stage Breast Cancer
Condition: Early Stage Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Interventional

Summary: 
      This phase II study based on the Cyberknife Society study will evaluate the technical
      feasibility and acute toxicity of Partial Breast Irradiation (PBI) with the Cyberknife. It
      will evaluate quality of life (QOL) issues as they relate to treatment-related side effects,
      cosmetic result and patient convenience. It will evaluate outcome in terms of local control
      in the treated breast.

      Radiosurgery is defined as the stereotactic delivery of ionizing radiation in 5 stages or
      less to a designated target with sub-millimeter accuracy. Radiosurgery in the context of this
      protocol will be given to the region of the tumor bed with 7 weeks of the lumpectomy and
      sent/axillary node sampling over the period of five to ten days using the Cyberknife (CK) or
      within the 7 weeks of the last chemotherapy treatment if given.
    


Intervention name(s): Cyberknife for Early Stage Breast Cancer
Intervention type(s): Radiation
Intervention description(s): Utilization of Cyberknife Robotic Radiosurgery as a 5-fraction post-lumpectomy adjuvant radiation treatment in the management of early stage breast cancer
Other intervention name(s): SBRT (Stereotactic Body Radiation Therapy)
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Depakote-ER for Depressive and Bipolar Depression
Condition: Bipolar Disorder
MeSH terms: Bipolar Disorder
Study type: Interventional
Phase: Phase 4

Summary: 
      Obtain information using a randomized treatment to assess the antidepressant and anxiolytic
      efficacy of divalproex vs. placebo for nonrefractory bipolar patients with major depressive
      episodes.
    

Detailed description: 
      Study is 6 weeks long, with 7 clinical visits.
    

Intervention name(s): Depakote-ER
Intervention type(s): Drug
Intervention MeSH terms: Valproic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
A Study to Evaluate the Long-Term Safety and Efficacy of GDC-0853 in Participants With Moderate to Severe Rheumatoid Arthritis Enrolled in Study GA29350
Condition: Rheumatoid Arthritis
MeSH terms: Arthritis; Arthritis, Rheumatoid
Study type: Interventional
Phase: Phase 2

Summary: 
      A study to evaluate the long-term safety and efficacy of GDC-0853 in participants with
      moderate to severe active Rheumatoid Arthritis (RA) who have completed 12 weeks of study
      treatment in Study GA29350. Eligible participants from Study GA29350 who elect to participate
      will receive treatment with GDC-0853 twice daily (BID) in an open-label fashion for 52 weeks,
      followed by a safety follow-up period of 8 weeks.
    


Intervention name(s): GDC-0853
Intervention type(s): Drug
Intervention description(s): GDC-0853 was administered orally at a dose of 200mg, as per the dosing schedules described above.
Other intervention name(s): RO7010939
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Woman Suffered From Leukocytopenia and Widespread Migration After Polyacrylamide Hydrogel (PAAG) Injection in Epicranial Aponeurosis
Condition: Complication
Study type: Observational

Summary: 
      Polyacrylamide hydrogel (PAAG) has been used as an injectable filler for soft tissue
      augmentation in different parts of the body , such as face, breast , or even penis for more
      than a decade . However, there are never reports about the application of a large amount of
      PAAG in epicranial aponeurosis to change the contour of the upper cranium accompanied with
      leukocytopenia. This fancy application turned out to be a disaster for the women who suffered
      from leukocytopenia , widespread migration of PAAG, recurrent swelling of the affected
      tissues and temporal pain changing with the temperature and the facial expression .
    


Observational model: Case-Only
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        A 50-year-old lady had PAAG injected into her bilateral temporal epicranial aponeurosis for
        augmentation
      
Keywords: Polyacrylamide hydrogel; leukocytopenia; migration; complication; epicranial aponeurosis; PAAG injection
BTK Inhibitor DTRMWXHS-12 in Mantle Cell Lymphoma
Condition: Mantle Cell Lymphoma
MeSH terms: Lymphoma; Lymphoma, Mantle-Cell
Study type: Interventional
Phase: Phase 1

Summary: 
      The Primary Objective is to evaluate the safety and tolerability of the DTRMWXHS-12 capsule
      in patients with relapsed/refractory MCL and recommend the dose and dosing method (RP2D) used
      in phase II study.

      The Secondary Objective is to evaluate the pharmacokinetics (PK) of multiple dose oral
      administration of DTRMWXHS-12 capsule in patients with relapsed/refractory MCL.

      The Exploratory Objective is to preliminarily evaluate the efficacy of DTRMWXHS-12 capsule in
      patients with relapsed/refractory MCL.
    


Intervention name(s): DTRMWXHS-12
Intervention type(s): Drug
Intervention description(s): DTRMWXHS-12 capsules: 150 mg, 300 mg
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Home Screening for Chlamydia Surveillance
Condition: Chlamydia Trachomatis; Gonorrhea
MeSH terms: Chlamydia Infections; Gonorrhea
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a randomized controlled trial to determine whether a home screening test for
      chlamydia and gonorrhea will lead to increased use of screening tests and increased detection
      of sexually transmitted diseases.
    

Detailed description: 
      This is a phase III randomized controlled trial. We enrolled 403 young women from a variety
      of clinical settings and neighborhoods in the Pittsburgh, PA region. Women completed a
      baseline questionnaire and then were randomized to either an intervention group (receive home
      testing kit every six months) or to a control group (receive a letter suggesting a clinic
      visit for screening). Participants were followed for 2 years, and medical chart abstraction
      was done to document tests done in clinical settings. The final study end points were number
      of tests completed, number of screening tests completed, number of STDs detected, and
      incident cases of pelvic inflammatory disease.
    

Intervention name(s): home testing kit
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Suiting up to Empathy
Condition: Empathy
Study type: Interventional

Summary: 
      Healthcare professionals with a positive attitude and empathetic towards older adults are at
      a better position to deliver quality healthcare. In this study, the investigators randomized
      pharmacy students to either a polypharmacy workshop or an immersive aging simulation suit and
      polypharmacy workshop to examine if simulation will enhance empathy levels among students
    

Detailed description: 
      Healthcare professionals with a positive attitude and empathetic towards older adults are at
      a better position to deliver quality healthcare. In this study, the investigators randomized
      pharmacy students to either a polypharmacy workshop or an immersive aging simulation suit and
      polypharmacy workshop to examine if simulation will enhance empathy levels among students.
      This will be performed in all year 1 pharmacy students
    

Intervention name(s): Use of an ageing suit; Polypharmacy workshop
Intervention type(s): Behavioral; Other
Intervention description(s): The simulation suit consists of a pair glasses which simulates narrowing of visual field; a pair of gloves ; a vest ; elbow and knee wraps and sand bags worn on the wrists and ankles; Participants will conduct a full medication review for older adults within 1 hour and develop a medication list which can be used for counselling of older adults
Other intervention name(s): PAUL Simulation Suit; Medication review polypharmacy workshop
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: randomised; simulation
A Pharmacokinetics (PK) Study in Lice Infested Children 6 Months to 3 Years of Age
Condition: Head Lice
MeSH terms: Lice Infestations
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine the bioavailability of 0.5% ivermectin cream in a
      pediatric population aged 6 months to 3 years.
    


Intervention name(s): 0.5% Ivermectin Cream
Intervention type(s): Drug
Intervention description(s): Topical 0.5% ivermectin cream applied to scalp and hair on day 1
Intervention MeSH terms: Ivermectin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Head Lice; Pediculus
YM443 in Subjects With Functional Dyspepsia
Condition: Indigestion; Nausea
MeSH terms: Nausea; Dyspepsia
Study type: Interventional
Phase: Phase 2

Summary: 
      The primary objective of this study will be to characterize the dose response profile of
      YM443 in subjects with functional dyspepsia (FD) to enable the selection of doses for the
      Phase 3 clinical trial.
    


Intervention name(s): YM443
Intervention type(s): Drug
Intervention MeSH terms: Z 338
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Nausea; Indigestion; Bloating; Functional Dyspepsia; Fullness after Meals
Psychological Symptom Change in Veterans After Six Sessions of EFT (Emotional Freedom Techniques)
Condition: Stress Disorders, Post-Traumatic
MeSH terms: Stress Disorders, Post-Traumatic
Study type: Interventional

Summary: 
      EFT (Emotional Freedom Techniques) has been shown to significantly reduce post-traumatic
      stress disorder (PTSD) and other psychological symptoms such as anxiety and depression in a
      variety of clinical trials. This study examines the effect of a six session EFT protocol on
      the symptoms of veterans with clinical scores on the PTSD Checklist-Military (PCL-M).
      Subjects in the experimental group receive EFT coaching supplemental to, and supportive of,
      the "usual care" treatment provided by their primary care provider. Subjects in the wait list
      control group receive usual care for a month, with pre and posttests, after which they also
      receive the EFT coaching protocol. Subjects are followed at three month intervals to
      determine if gains are maintained, and whether the symptom reductions are similar to those
      observed in other trials of EFT.
    


Intervention name(s): EFT (Emotional Freedom Techniques)
Intervention type(s): Behavioral
Intervention description(s): Six sessions of EFT
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: veterans,; PTSD,; EFT (Emotional Freedom Techniques),; depression,; anxiety
A Study to Assess the Long-term Performance of SmartSet® HV and SmartSet® GHV Bone Cements in Primary Total Hip Replacement
Condition: Rheumatoid Arthritis; Osteoarthritis; Post-traumatic Arthritis; Collagen Disorders; Avascular Necrosis; Traumatic Femoral Fractures; Nonunion of Femoral Fractures; Congenital Hip Dysplasia; Slipped Capital Femoral Epiphysis
MeSH terms: Arthritis; Hip Dislocation; Developmental Dysplasia of the Hip; Hip Dislocation, Congenital; Slipped Capital Femoral Epiphyses; Rheumatic Diseases; Collagen Diseases; Necrosis; Fractures, Bone; Femoral Fractures
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to monitor the performance of artificial hip joints implanted
      with two different bone cements, SmartSet® HV and SmartSet® GHV, in the treatment of patients
      with hip joint disease requiring a total hip replacement. Patients who enter the study will
      be randomly allocated to SmartSet® HV or SmartSet® GHV and will be evaluated at regular
      intervals following hip surgery using patient, clinical and x-ray assessments
    


Intervention name(s): SmartSet® HV bone cement; SmartSet® GHV bone cement
Intervention type(s): Device; Device
Intervention description(s): A high viscosity bone cement for use in total hip replacement (without gentamicin); A high viscosity bone cement for use in total hip replacement (with gentamicin)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Hip; Bone Cement
Controlled Level EVERolimus in Acute Coronary Syndromes
Condition: Acute Coronary Syndromes
MeSH terms: Acute Coronary Syndrome; ST Elevation Myocardial Infarction; Syndrome
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Acute myocardial infarction (AMI) constitutes the major cause of death in most nations and
      death rates and morbidity remain substantial in the years thereafter. Inflammation is a
      hallmark throughout the distinct stages of atherosclerotic lesion formation preceding AMI as
      well as at the time of plaque rupture and during the post-infarct repair phase. Harnessing
      its harmful consequences constitutes an attractive therapeutic approach to address this unmet
      medical need.

      The objectives of this study are to evaluate the effects of mTOR inhibition (everolimus) on
      infarct size, myocardial function and inflammation in patients with ST-Elevation Myocardial
      Infarction.

      The efficacy objectives are:

        1. (1° endpoint):

           To assess the effect of mTOR inhibition (everolimus) on myocardial infarct size as
           change from baseline (12-72 hours after percutaneous coronary intervention) to 30 days
           follow-up measured by MRI (Late Gadolinium Enhancement (LGE) for transmurality).

        2. (2° endpoint):

           To evaluate microvascular obstruction (MVO) as change from baseline (12-72 hours after
           percutaneous coronary intervention) to 30 days follow-up evaluated by MRI.

        3. (3° endpoints):

             1. Change of left ventricular volume from baseline (12-72 hours after percutaneous
                coronary intervention) to 30 days follow-up measured by MRI.

             2. Change of biomarkers from time of coronary angiography to 30 days follow-up
                including a time-course (AUC). Biomarkers comprise hs-TnT, NT-proBNP, hs-CRP, IL-6
                and inflammatory biomarkers OPG, sRANKL, OPN and CCN1.

      The safety objectives are:

      To explore the effect of mTOR inhibition (everolimus) on several clinical and safety
      laboratory parameters including plasma lipid levels and blood count. This will be
      complemented by analysis of inflammatory cell subsets in coronary thrombi and peripheral
      blood (CD4+ T helper lymphocyte subsets, monocyte subsets).
    


Intervention name(s): Everolimus; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): (d0=7.5 mg, d1=7.5 mg. d2=7.5 mg, d3=5 mg, d4=5mg); matched placebo tablets manufactured to be identical to verum tablets except content of everolimus
Intervention MeSH terms: Everolimus
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Acute Coronary Syndromes; ST-Elevation Myocardial Infarction; Infarct size; inflammation; everolimus
Multifocal Brain Magnetic Stimulation in Chronic Ischemic Stroke
Condition: Stroke
MeSH terms: Stroke; Ischemic Stroke
Study type: Interventional

Summary: 
      Transcranial magnetic stimulation for post-stroke upper-body motor deficits.
    

Detailed description: 
      This study uses transcranial magnetic stimulation (magnetic pulses delivered through a
      specially designed cap worn on the head aimed at specific motor areas of the brain (brain
      areas responsible for the body's physical movements) to test whether upper-body motor
      function can be improved.

      This is a double-blind study where half of participants will receive active transcranial
      stimulation and the other half of the participants will receive no transcranial magnetic
      stimulation; all participants will wear the cap. Participants and some members of the
      research team will not know who received active magnetic brain stimulation.
    

Intervention name(s): repetitive Transcranial Magnetic Stimulation -On; repetitive Transcranial Magnetic Stimulation -Off
Intervention type(s): Device; Device
Intervention description(s): Cap worn on the scalp will deliver active Repetitive Transcranial Magnetic Stimulation to specific parts of the brain; Cap worn on the scalp will no delivery of the Repetitive Transcranial Magnetic Stimulation to any part of the, referred to as a sham or inactive study treatment.
Other intervention name(s): transcranial magnetic stimulation (TMS); Transcranial Rotating Permanent Magnet Stimulation (TRPMS); repetitive Transcranial Magnetic Stimulation (rTMS); sham treatment; Control Group
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Active repetitive transcranial magnetic stimulation administered through cap worn by patient under healthcare provider.
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Stroke; chronic ischemic stroke; cerebrovascular accident (CVA); ischaemic stroke