bioihbjkbjnl/mcl2 huggingface dataset:
Comparison of Videogame Based Dance Training With Agility Ladder Drills on Agility of Volleyball Players
Condition: Healthy Athletes
Study type: Interventional

Summary: 
      This study will examine the effects of six week dance training, using the Xbox Kinect Just
      Dance 2014 programme, on the agility scores along with general and hamstring flexibility and
      extensibility of the hip flexor. The effects of the dance programme will be compared with
      those of proven agility training techniques (ladder drills).
    

Detailed description: 
      A randomised clinical trial will be used consisting of 34 (17 in each group) athletes
      undergoing training. Both groups will undergo one hour of training three times weekly for six
      weeks, with one group doing dance training (DT) using the Xbox Kinect and the other doing
      standard training (ST) using traditional ladder drills. Outcomes will be assessed using the
      Illinois Agility test for agility, sit and reach test for general flexibility, straight leg
      raise test for hamstring flexibility and the Thomas test for hip flexor extensibility.
    

Intervention name(s): XBOX Kinect Just Dance 2014; Agility Ladder Drills
Intervention type(s): Device; Other
Intervention description(s): The XBOX Kinect Just dance 2014 is videogame based interactive dance programme designed to encourage activity while gaming.; Types of ladder drill exercises including single leg hop right and left leg, bunny hop, slalom jumps, bunny twist, lateral runs right and left, high knees with forward progression, backward run, bunny hop backward, single leg lateral hops, lateral bunny hops and snake carrioca moguls.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Pronto-7: Accuracy of Non-invasive Hemoglobin Measurement in Parturients
Condition: Hemoglobin Levels in Blood
Study type: Observational

Summary: 
      The measurement of blood hemoglobin (Hb) concentration is a routine procedure in pregnant
      women. The assessment of Hb involves several steps, including a needle stick, blood
      collection, blood sample analysis in the laboratory, and waiting for the results.

      Pronto-7 (manufactured by Masimo, CA, USA) is a new portable device that allows a quick
      bedside Hb spot check. A finger clip probe, similar to the standard oxygen finger clip probe,
      provides hemoglobin values in less than 60 seconds.

      In this prospective observational study the investigators will assess the clinical accuracy
      of Pronto-7 derived Hb values compared to the gold standard laboratory Hb values in obstetric
      patients. We will be calculating the mean difference between Pronto-7 and laboratory Hb
      values. We plan to recruit 55 pregnant women admitted for vaginal or cesarean delivery at BC
      Women's Hospital.
    

Detailed description: 
      Serum hemoglobin (Hb) concentration is one of the most common laboratory tests measured when
      a pregnant woman (parturient) is admitted for a vaginal or cesarean delivery. The Hb
      concentration is normally measured from a venous blood sample in clinical laboratories using
      co-oximetry.

      A new point-of-care pulse co-oximeter, the Pronto-7 (Masimo Corporation, Irvine, CA, USA), is
      a portable device that offers a non-invasive and quick spot-checking of Hb (SpHb).
      Measurement with the Pronto-7 takes about 60 seconds and does not require the transfer of
      blood samples to a laboratory. In addition to SpHb, the device provides a perfusion index
      (PI) value (a numeric estimation of the pulse strength at the measurement site), heart rate,
      oxygen saturation, and finger temperature. Potential advantages of the Pronto-7 include
      reduced staff work, decreased exposure to potential biohazards, and reduced pain and
      discomfort to the patient.

      A similar technology is used in Radical-7 pulse co-oximeter (Masimo Corporation, Irvine, CA,
      USA) for non-invasive Hb measurement. Radical-7 has been evaluated in human volunteers
      undergoing hemodilution, in patients undergoing spine surgeries, major urological procedures,
      and in critically ill patients. However, the results regarding the accuracy of this
      technology are conflicting.
    

Intervention name(s): Pronto-7
Intervention type(s): Device
Intervention description(s): A new point-of-care pulse co-oximeter that offers a non-invasive and quick spot-checking of Hb (SpHb).
Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Pregnant women admitted to the British Columbia Women's Hospital for vaginal or cesarean
        delivery (either elective or emergency).
      
Keywords: Pronto-7; SpHb; Obstetric patients
A Study to Investigate the Effect of Formulation, Food, and Rabeprazole on the Pharmacokinetics (PK) of GDC-0853 in Healthy Participants
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the PK of GDC-0853 following changes to formulation
      and in the presence or absence of food, the proton pump inhibitor (rabeprazole), or both.
      This will be a 3-part open-label randomized study conducted in healthy adult participants.
      Approximately 63 subjects will be enrolled in this study.
    


Intervention name(s): GDC-0853; Rabeprazole
Intervention type(s): Drug; Drug
Intervention description(s): Participants will receive different formulations of GDC-0853 tablet.; Participants will receive rabeprazole 20 mg twice daily (BID) for three days prior to GDC-0853 administration and a single dose coadministered with GDC-0853.
Other intervention name(s): RO7010939
Intervention MeSH terms: Rabeprazole
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Evaluation of Safety and Efficacy of Carbon Dioxide (CO2) Acupulse Laser Treatment on Vaginal Elasticity.
Condition: Exposure Laser
Study type: Interventional

Summary: 
      The study is intended to assess the safety and efficacy of CO2 AcuPulse laser treatment in
      patients with vaginal prolapse. Eligible subjects will receive 3 treatment sessions, 4 weeks
      apart and 3 Follow Up visits, at 1, 3, and 6 months following the last treatment.
    

Detailed description: 
      Following a screening visit, eligible subjects will be enrolled into the study. Each subject
      will receive 3 treatments 4 weeks apart and 3 Follow Up visits, at 1, 3, and 6 months
      following the last treatment.

      Further demographic information and patient history will be obtained from the subjects'
      electronical files.
    

Intervention name(s): CO2 AcuPulse Laser
Intervention type(s): Device
Intervention description(s): Each subject will receive 3 treatments 4 weeks apart and 3 Follow Up visits, at 1, 3, and 6 months following the last treatment.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Study to Assess the Bioequivalence of a New ULTRACET Extended Release (ER) Tablet With Respect to a Marketed ULTRACET ER Tablet Under Fasted Condition
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the bioequivalence of a newly developed ULTRACET
      extended-release (ER) tablet of tramadol hydrochloride and acetaminophen, to the current
      marketed ULTRACET ER tablet, in healthy participants under fasted condition.
    


Intervention name(s): Tramadol HCl 75 mg/Acetaminophen 650 mg (Newly developed ULTRACET ER); Tramadol HCl 75 mg/Acetaminophen 650 mg (Marketed ULTRACET ER)
Intervention type(s): Drug; Drug
Intervention description(s): Single oral dose of newly developed ULTRACET ER, (Tramadol HCl/Acetaminophen 75/650 mg), administered under fasted condition.; Single oral dose of marketed ULTRACET ER, (Tramadol HCl/Acetaminophen 75/650 mg), administered under fasted condition.
Intervention MeSH terms: Acetaminophen; Tramadol
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Healthy; Ultracet extended release (ER); Tramadol hydrochloride; Acetaminophen; Bioequivalence
Investigation of Long-term Effects of CarelessTM on Microcirculation
Condition: Disorder of Circulatory System; Metabolic Disease
MeSH terms: Metabolic Diseases
Study type: Interventional

Summary: 
      Aim of the study is to investigate long-term effects of CarelessTM, a Mangifera indica fruit
      powder on microcirculation and endothelial function after supplementation of 4 weeks. Effects
      will be investigated with 100mg and 300mg CarelessTM and compared to placebo.
    

Detailed description: 
      Aim of the study is to investigate long-term effects of CarelessTM, a Mangifera indica fruit
      powder on microcirculation and endothelial function after supplementation of 4 weeks. Effects
      will be investigated with 100mg and 300mg CarelessTM and compared to placebo.

      To describe targeted parameter, cutaneous microcirculation will be measured at 1 mm depth as
      well as flow mediated endothelial function at the beginning and end of supplementation, each.
      Furthermore, the parameters will be determined postprandially 1 hour after glucose loading.
      Additionally the influence on the glucose metabolism, as well as on body weight and body fat
      will be documented.
    

Intervention name(s): Mango fruit powder
Intervention type(s): Dietary Supplement
Intervention description(s): Investigation of long-term effects of CarelessTM on microcirculation in healthy volunteers - a randomized, double-blind, placebo-controlled study with parallel design
Other intervention name(s): CarelessTM
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Effect of Palmitoylethanolamide on Proinflammatory Markers in Adults Recently Diagnosed With COVID-19
Condition: Inflammation; COVID19
MeSH terms: COVID-19; Inflammation
Study type: Interventional

Summary: 
      Two randomized controlled trials will be conducted to examine the effect of a food supplement
      on proinflammatory cytokines and biomarkers in an adult population recently diagnosed with
      COVID-19 who are asymptomatic or experiencing only mild symptoms. The supplement,
      palmitoylethanolamide (PEA), is marketed under the trademarked product with increased
      bioavailability and format versatility: Levagen+™ (Gencor Pacific Limited, Irvine, CA). The
      supplement curcumin is marketed under the trademarked product with increased bioavailability:
      HydroCurc (Gencor Pacific Limited, Irvine, CA)
    

Detailed description: 
      Inflammation is at the core of many chronic conditions and exacerbates infectious conditions,
      and inflammatory responses appear to be key determinants of the severity of COVID-19
      infection. Hence, controlling inflammation is considered a key strategy for slowing the
      progression of disease and tissue pathology. This research offers a natural, dietary approach
      to managing inflammation by reducing the mediators of inflammation. The beneficial effects of
      palmitoylethanolamide (PEA) and for curcumin for reducing inflammation is documented in the
      research literature. The proposed research will expand this literature in a novel manner. The
      investigators propose to demonstrate the efficacy of these dietary supplements in individuals
      from a campus population with robust immune protection - those who recently tested positive
      for COVID-19 but were asymptomatic or mildly symptomatic. Since a college population is under
      many stressors which raise inflammatory profiles during the academic year, and since a
      college population is exposed to infectious agents on campus, maintaining strong protective
      immune system following a COVID-19 infection is important.
    

Intervention name(s): palmitoylethanolamide; Placebo; Curcumin; Control (microcrystalline cellulose)
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): 4 tablets taken daily (2 in the am and 2 in the pm); 4 tablets taken daily (2 in am and 2 in pm); 500 mg HydroCurc® twice a day; 2 tablets taken daily
Other intervention name(s): Levagen; microcrystalline cellulose; Hydrocurc; microcrystalline cellulose
Intervention MeSH terms: Palmidrol; Curcumin
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: double-blind, randomized, controlled trial
Masking: Double (Participant, Investigator)
Primary purpose: Supportive Care
Keywords: palmitoylethanolamide; curcumin
Crossover Trial to Assess Efficacy and Safety of Inhaled AQ001S Compared to a Budesonide Suspension in Mild Asthmatics
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This is a prospective, active-controlled, randomized, open label, single-center, multiple
      dose, two-period crossover clinical trial to assess the efficacy, safety and pharmacokinetics
      of AQ001S compared to a budesonide inhalation suspension (comparator) in adults with mild
      asthma.

      Both treatments will be administered by nebulization.
    

Detailed description: 
      Adults patients with mild asthma (18 to 65 years old), who are 'inhaled corticosteroid
      (ICS)'-naïve for minimum 60 days at Screening Visit will be enrolled in the study. The
      patients will be treated for 28 days. The primary endpoint will be assessed by a provocative
      concentration of methacholine that results in a 20% drop (PC20) in the first second forced
      expiratory volume (FEV1) as determined by methacholine challenge test. The pharmacokinetics
      (PK) endpoint, i.e. PK profile of budesonide in plasma, and pharmacodynamics (PD) endpoints,
      i.e. recording of symptom scores, use of reliever drugs as needed, biomarkers of airway
      inflammation and pulmonary function tests will be assessed during the study.
    

Intervention name(s): AQ001S 0.125 mg/ml; Budesonide 0.125 mg/ml inhalation suspension
Intervention type(s): Drug; Drug
Intervention description(s): administered by nebulization once daily; administered by nebulization once daily
Other intervention name(s): budesonide inhalation solution 0.125 mg/ml; Budesonide inhalation suspension 0.125 mg/ml
Intervention MeSH terms: Budesonide
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Ankle Athletic Taping Fatigue After a Standard Tennis Warm up
Condition: Ankle Injuries
MeSH terms: Ankle Injuries
Study type: Interventional

Summary: 
      Identify, quantify and compare the fatigue caused in two ankle athletic tapes after the
      completion of a tennis warm-up.
    


Intervention name(s): Modified ankle athletic taping; Traditional ankle athletic taping
Intervention type(s): Procedure; Procedure
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Investigator)
Keywords: athletic tape; tennis; warm-up exercise
Botulinum Toxin Injection in Reducing Lip Scar Following Cleft Lip Repair
Condition: Cleft Lip
MeSH terms: Cleft Lip
Study type: Interventional

Summary: 
      A cleft lip is a congenital defect resulting from failing to merge developmental processes in
      the Orofacial region. One of the most common complications surgeons fear after cleft lip
      repair is a hypertrophic scar. A cleft scar negatively affects a patient's appearance,
      psychology, and function. Several techniques have been proposed to improve lip scars such as
      steroid therapy, laser therapy, and silica gel. Despite such efforts, the results were still
      unsatisfactory. Botulinum Toxin injections may provide a more reliable method
    


Intervention name(s): Botulinum; Fisher technique
Intervention type(s): Other; Procedure
Intervention description(s): injection of Botulinum Toxin injection in lip muscles following cleft lip repair surgically.; The cleft lip will be treated surgically using the Fisher technique only.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
AC-1204 26-Week Long Term Efficacy Response Trial With Optional Open-label Ext
Condition: Alzheimer's Disease
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      This study will evaluate the effects of daily dosing of AC-1204 on cognition, activities of
      daily living, resource utilization, quality of life, pharmacokinetic measures and safety
      among participants with mild to moderate Alzheimer's Disease.
    


Intervention name(s): AC-1204; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): AC-1204 taken once daily, by mouth; Placebo taken once daily, by mouth
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
CDC Medicaid Asthma Home Visit Project
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional

Summary: 
      Asthmatic children age 3-17 from low income households in King County are randomly assigned
      into a community health worker (CHW) intervention group and a control group. The intervention
      is in-home education and support related to asthma self-management. The main outcome measures
      are asthma symptom-free days, caretaker's asthma-related quality of life score, and health
      care utilization for asthma measured at baseline and 12 months after baseline enrollment.
    

Detailed description: 
      This is a randomized controlled trial. Potentially eligible subjects come from lists
      generated by health plans (Community Health Plan of Washington and Molina, who insure the
      majority of Medicaid enrollees in King County), individuals referred by primary care
      providers, and self referral. Eligible subjects that agree to participate are randomly
      assigned into a CHW intervention group or a control group. We expected to complete the study
      with 200 in each group.

      The intervention is in-home education and support by a community health worker (CHW). At the
      first home visit, the CHW assesses the participant's knowledge and skills related to asthma
      self-management, current status of the child's asthma, and resources and support for asthma
      self-management using a baseline questionnaire. The CHW inspects the home environment using
      an Environmental Home Checklist to identify environmental triggers that can cause asthma
      symptoms and affect asthma control. The CHW makes up to three follow-up visits and two
      telephone visits during the year the participant is in the study. Participants receive
      resources to help them control asthma, including vacuum cleaner, dust covers for a pillow and
      mattress and a "green" cleaning kit with cleaning supplies.

      The control group receives standard asthma care, as provided by a primary health care
      provider during the 12 months after enrollment. When the intervention period is over, the
      control group receives one visit with a CHW and the resources provided to the intervention
      group participants.

      The main outcome variables include asthma symptom-free days, caretaker asthma-related quality
      of life, and urgent health care utilization.
    

Intervention name(s): CHW intervention
Intervention type(s): Behavioral
Intervention description(s): Home education and support for asthma self management
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
High Resistant Starch (RS) Cookies and Appetite Control
Condition: Metabolic Syndrome
MeSH terms: Metabolic Syndrome
Study type: Interventional
Phase: Early Phase 1

Summary: 
      Evaluation of the effect of ingestion of high RS-cookies prepared from high amylose corn
      starch on food intake and appetite control of a cohort of healthy students. Cookies were
      prepared with increasing RS content and were fed to 18 healthy students in a blind trial
      versus a placebo.

      Parameters of interest were: short and long time intake (ad libitum test meal and 12 h diet
      diaries, respectively).
    


Intervention name(s): High RS cookies; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): High RS cookies ingestion in healthy young adults; Placebo cookies ingestion in healthy young adults
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Effects of Different Kinds of Hypotensive Drugs on Dynamic Hemodynamic Changing in Patients Under Surgeries
Condition: General Surgery
Study type: Interventional

Summary: 
      SVV is clinically affected by a variety of factors, such as abdominal pressure, body
      position, tidal volume, type and temperature of liquid treatment, etc. There are few reports
      on the effects of drugs on SVV.

      In clinical anesthesia, surgical stimulation and stress can affect patient hemodynamic
      stability, used in intraoperative vascular active drug is inevitable, they shrink or dilate
      blood vessels, speed up or slow down the heart rate, makes the ventricular preload and
      corresponding changes in the SV. Now, there is a study on SVV and PPV in patients with
      hypertension, but there are few reports on the effect of blood pressure drugs on the changes
      in patients' threshold.
    


Intervention name(s): Nicardipine; Urapidil
Intervention type(s): Drug; Drug
Intervention description(s): The patients in Group N were infused the 130/0.4 hydroxyethyl starch and sodium chloride injection ( 7 ml/kg, 0.4 ml/kg/min) after anesthesi induction and before skin incision. Then the HR, SAP, DAP, MAP, CO, CI, SV, SVI, PPV and SVV were recorded. When the circulation was stability, Nicardipine was given, and the the 130/0.4 hydroxyethyl starch and sodium chloride injection was infused again.; The patients in Group N were infused the 130/0.4 hydroxyethyl starch and sodium chloride injection ( 7 ml/kg, 0.4 ml/kg/min) after anesthesi induction and before skin incision. Then the HR, SAP, DAP, MAP, CO, CI, SV, SVI, PPV and SVV were recorded. When the circulation was stability, Urapidil was given, and the the 130/0.4 hydroxyethyl starch and sodium chloride injection was infused again.
Intervention MeSH terms: Nicardipine; Urapidil
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Diagnostic