Anti-Inflammatory Efficacy of Ginger Containing Dentifrice in the Control of Biofilm Induced Gingivitis
Condition: Gingivitis
MeSH terms: Gingivitis
Study type: Interventional
Phase: Phase 3

Summary: 
      The goal of this clinical trial is to test efficiency of using toothpaste containing (Ginger)
      over a period of three month to control on gingival inflammation and plaque accumulation
      through measuring the clinical periodontal parameters (Gingival Index (GI), Bleeding on
      probing (BOP) and modified Quigley-Hein Plaque Index (mQHPI ) in comparison with Colgate
      total toothpastes in patients with biofilm induced gingivitis.
    

Detailed description: 
      Objectives:

        1. Measuring the clinical periodontal parameter (gingival index) and salivary cytokine
           IL-1β and superoxide dismutase SOD over a period 3 months before and after using
           Capitano (ginger containing) and Colgate total toothpastes for patients with gingivitis.

        2. Measuring the clinical periodontal parameter ((Gingival Index (GI), Bleeding on probing
           (BOP) and modified Quigley-HeinPlaque Index (mQHPI )) over a period 3 months before and
           after using Capitano (ginger containing) and Colgate total toothpastes for patients with
           gingivitis by ELISA.

        3. correlation between ( Interleukin 1 beta and SOD) and clinical periodontal parameters
    

Intervention name(s): Capitano zenzero toothpaste; Colgate total toothpaste
Intervention type(s): Drug; Drug
Intervention description(s): Filming toothpate formulation, enriched with 3%ginger as active ingredient and Zinc coco sulfate as surfactant, cleansing and emulsifying agent.
Subjectswill then be given the test intervention, Capitano zenzero toothpaste, and will be asked to brush with it for two minute twice per day and will be instructed torefrain from eating and drinking for 30 min after brushing. participants will be received a toothbrush with medium-hardness bristles .the bass technique method of brushing by was comprehensively explained to all participants.. Next, the participants will be re-evaluated after 3 months .; Subjects will then be given Colgate total toothpaste, as an active comparator, and will be asked to brush with it for two minutes twice per day and will be instructed to refrain from eating and drinking for 30 min after rinsing. participants will be received a toothbrush with medium-hardness bristles . participants will be received a toothbrush with medium-hardness bristles .the bass technique method of brushing by was comprehensively explained to all participants.. Next, the participants will be re-evaluated after 3 months .
Other intervention name(s): Ginger toothpaste
Intervention MeSH terms: Listerine; Sodium Fluoride
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 80 subjects with plaque induced gingivitis, caused by accumulation of plaque, will be selected and enrolled in this study. Subsequently, subjects will be equally divided and randomly allocated for two groups, each group received a similar number of subjects (n=40) with a 1:1 allocation.
Masking: Double (Participant, Investigator)
Primary purpose: Treatment