Evaluation of Serum Levels of C Reactive Protein (CRP) and Its Correlation With Fetal Ultrasound Parameters in the Prediction of Threatened Miscarriage in the First Trimester
Condition: Threatened Miscarriage
MeSH terms: Abortion, Spontaneous; Abortion, Threatened
Study type: Observational

Summary: 
      The goal of this observational study is to evaluate and compare in pregnant women with
      threatened miscarriage in the first trimester. The main questions it aims to answer are:

      What is the correlation between serum C reactive protein (CRP) levels and fetal ultrasound
      parameters in predicting threatened miscarriage? How accurate are serum C reactive protein
      (CRP) levels versus ultrasound in predicting pregnancy loss in threatened miscarriage?
      Participants will have blood tests to measure C reactive protein (CRP) levels and fetal
      ultrasound exams to assess parameters like crown-rump length.

      Researchers will compare serum C reactive protein (CRP) levels and fetal ultrasound findings
      to see if either or both can accurately predict pregnancy loss in women with first trimester
      threatened miscarriage.
    

Detailed description: 
      This observational study will enroll 100 pregnant women, with 50 in the threatened
      miscarriage group and 50 healthy controls, to compare serum C reactive protein (CRP) levels
      and fetal ultrasound findings for predicting early pregnancy loss.

      Women presenting with first trimester bleeding and cramps concerning for threatened
      miscarriage will undergo blood testing to measure C reactive protein (CRP) levels and fetal
      ultrasound to assess parameters including crown-rump length, heartbeat, yolk sac size, and
      embryonic motion.

      The control group will consist of 50 low-risk pregnant women without threatened miscarriage
      matched for gestational age. Controls will undergo the same blood and ultrasound assessments.

      Researchers will compare serum C reactive protein (CRP) levels and ultrasound measurements
      between the threatened miscarriage and control groups. They will analyze which parameters
      differ significantly between groups and examine the predictive utility of C reactive protein
      (CRP) levels versus ultrasound for determining pregnancy viability.

      Key outcomes will include correlation of C reactive protein (CRP) with ultrasound parameters,
      and diagnostic accuracy of C reactive protein (CRP) levels versus ultrasound in predicting
      pregnancy loss in threatened first trimester miscarriages.

      This study aims to help optimize early pregnancy loss prediction and counseling for women
      with potential threatened miscarriage.
    

Intervention name(s): Serum C reactive protein (CRP) level; Ultrasound
Intervention type(s): Diagnostic Test; Diagnostic Test
Intervention description(s): An immunoturbidimetric method using a Modular P Analyzer will be used to carry out HSCRP assay, with a quantitation limit of 0.5 mg/L.; All examinations will be carried out by an experience operator with a transvaginal probe on high-resolution ultrasound machines. Pregnancies will be dated from the LMP. Other measurements will be obtained during the scan as the mean gestation sac diameter, volume of the gestation sac and the embryonic heart rate (FHR).
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The study population will consist of 100 pregnant women, including 50 with threatened
        miscarriage and 50 healthy controls, recruited from obstetrics clinic at Al-Hussein
        University Hospital
      
Keywords: threatened miscarriage; ultrasound parameters; C reactive protein; first trimester