The Effects of Supplementation of Conjugated Linoleic Acid on Body Fat Reduction
Condition: Obesity; Adiposity
MeSH terms: Obesity
Study type: Interventional

Summary: 
      This is a double-blinded randomized controlled trial, to evaluate the effectiveness of daily
      supplementation of 3.2 g CLA on body fat reduction and lipid profile in overweight or obese
      Chinese adults, during a lifestyle counselling-based weight loss.
    

Detailed description: 
      This will be a parallel randomized, double-blinded, placebo-controlled trial. Sixty-six
      overweight or obese men and women aged from 18 to 45 years with elevated body fat percentage,
      who also meet our inclusion and exclusion criteria, will be randomly assigned to: the
      treatment group, daily supplementation of 3.2 g CLA (Cis-9, trans-11 isomers and trans-10,
      cis-12 isomers) plus lifestyle counselling weight loss program; or the control group, daily
      supplementation of sunflower oil. The intervention will include a 3-day run-in phase and
      12-week interventional phase. At baseline and the end of the intervention, physical
      examination including questionnaires, anthropometric measurement, body composition by Dual
      Energy X-ray Absorptiometry (DXA), biological sample collection will be undertaken. During
      the invention, regular lifestyle counselling sessions will be delivered, and detailed record
      will be tracked for all participants to monitor and improve the adherence and safety.
    

Intervention name(s): Conjugated linoleic acid group; Sunflower oil group
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): supplementation of 3.2 g/day conjugated linoleic acid in 8 capsules, and receive education sessions every four weeks (Dietary and lifestyle counselling, featured with low fat and low added sugar, moderate physical activity); supplementation of equivalent sunflower oil in 8 capsules, and receive education sessions every four weeks (Dietary and lifestyle counselling, featured with low fat and low added sugar, moderate physical activity)
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: This will be a parallel randomized, double-blinded, placebo-controlled trial. Sixty-six overweight or obese men and women aged from 18 to 50 years with elevated body fat percentage, who also meet our inclusion and exclusion criteria, will be randomly assigned to: the treatment group, daily supplementation of 3.2 g CLA (Cis-9, trans-11 isomers and trans-10, cis-12 isomers) plus lifestyle counselling weight loss program; or the control group, daily supplementation of sunflower oil. The intervention will include a 3-day run-in phase and 12-week interventional phase. At baseline and the end of the intervention, physical examination including questionnaires, anthropometric measurement, body composition by Dual Energy X-ray Absorptiometry (DXA), biological sample collection will be undertaken. During the invention, regular lifestyle counselling sessions will be delivered, and detailed record will be tracked for all participants to monitor and improve the adherence and safety.
Masking: Double (Participant, Investigator)
Primary purpose: Treatment