Interaction Between Chlorhexidine and Fluoride
Condition: Periodontal Disease; Dental Caries
MeSH terms: Dental Caries; Periodontal Diseases
Study type: Interventional
Phase: Phase 4

Summary: 
      The aim of the present study was to study if there are interactions and reduced clinical
      effect between chlorhexidine and fluoride when they are combined in the same mouthrinse.
    

Detailed description: 
      The investigation assessed the clinical effect of a mouthrinse containing chlorhexidine (CHX)
      and sodium fluoride (NaF) during a 4-day period of non-brushing and a 6-week period of
      brushing. Two studies were designed as double-blind, randomized, cross-over clinical trials.
      In study I, 16 healthy subjects rinsed twice daily for 1 min during 4 days of no tooth
      brushing with four mouthrinse solutions: 1) 0.12% CHX + 0.2% NaF, 2) 0.2% NaF, 3) 0.12% CHX,
      and 4) placebo. In study 2, 16 healthy subjects rinsed with the same four solutions twice
      daily after tooth brushing during a 6-week period. Primary outcomes were plaque formation and
      gingivitis. Secondary outcomes were fluoride retention and microbiological parameters in
      plaque and saliva (total bacterial counts and mutans streptococci, lactobacilli and
      streptococci sanguinis counts). One way analyses of variance with post hoc
      Student-Newman-Keul´s statistical test was performed for comparisons between mouthrinses.
      Intragroup changes over time were analyzed with a paired t-test.
    

Intervention name(s): 0.12 % chlorhexidine + 0.2 % NaF mouthrinse; 0.2 % NaF mouthrinse; 0.12% chlorhexidine; Placebo
Intervention type(s): Drug; Drug; Drug; Other
Intervention description(s): In study I, subjects were asked to refrain from tooth brushing and interdental cleaning and rinse with 10 ml of the assigned test solution for one minute, twice daily (morning and evening) during 4 days.
In study II, subjects were asked to rinse with 10ml of the assigned test solution twice daily after tooth brushing during a 6-week period.; In study I, subjects were asked to refrain from tooth brushing and interdental cleaning and rinse with 10 ml of the assigned test solution for one minute, twice daily (morning and evening) during 4 days.
In study II, subjects were asked to rinse with 10ml of the assigned test solution twice daily after tooth brushing during a 6-week period.; In study I, subjects were asked to refrain from tooth brushing and interdental cleaning and rinse with 10 ml of the assigned test solution for one minute, twice daily (morning and evening) during 4 days.
In study II, subjects were asked to rinse with 10ml of the assigned test solution twice daily after tooth brushing during a 6-week period.; Contained all basic ingredients as the other three mouthrinses but no chlorhexidine and no NaF. In study I, subjects were asked to refrain from tooth brushing and interdental cleaning and rinse with 10 ml of the assigned test solution for one minute, twice daily (morning and evening) during 4 days.
In study II, subjects were asked to rinse with 10ml of the assigned solution twice daily after tooth brushing during a 6-week period.
Other intervention name(s): Chlorhexidine + NaF mouthwash; NaF mouthwash; Chlorhexidine mouthwash
Intervention MeSH terms: Chlorhexidine; Chlorhexidine gluconate
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Prevention