bioihbjkbjnl/mcl2 huggingface dataset:
Effect of Alternate Therapies on Intraocular Pressure in Ocular Hypertension
Condition: Ocular Hypertension
MeSH terms: Ocular Hypertension; Glaucoma; Hypertension
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the effect of complementary and alternative
      therapies, specifically alternate nostril breathing and foot reflexology, on intraocular
      pressure in patients with ocular hypertension.
    

Detailed description: 
      11 patients were recruited from Temple Ophthalmology between 2014 and 2016. Patients had
      ocular hypertension and were between the ages of 48-74. Patients were excluded if they
      currently performed ANB or FR, were unable to perform the task, had previous eye surgery or
      laser, were receiving other CAM for ocular hypertension, or were unable to complete a washout
      period. After a 30-day drug washout, patients completed either ANB or FR. After instruction,
      the assigned task was performed for 5 minutes. FR was done on a commercially available foot
      reflexology board (JAPAN TSUBO HH-700) focused at the base of the second and third toes of
      both feet. Two weeks later, patients completed the alternate task. IOP was measured before
      the task, immediately after the task and then every 30 minutes for two hours. Sign rank tests
      were used to evaluate IOP changes within and between each group.
    

Intervention name(s): Alternate Nostril Breathing; Foot Reflexology
Intervention type(s): Other; Device
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Virtual Reality by Mobile Phone: Improving Child Pedestrian Safety
Condition: Child Pedestrian Safety
Study type: Interventional

Summary: 
      The investigators will conduct a non-inferiority clinical trial to evaluate whether children
      trained in pedestrian safety amidst a Google Cardboard virtual environment achieve equivalent
      levels of pedestrian safety to children trained in a full semi-immersive virtual pedestrian
      environment
    


Intervention name(s): pedestrian safety training in pedestrian virtual environment
Intervention type(s): Behavioral
Intervention description(s): pedestrian safety training
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
The Effect of Schroth Exercises on Pulmonary Function in Adolescent Idiopathic Scoliosis
Condition: Adolescent Idiopathic Scoliosis; Pulmonary Function
MeSH terms: Scoliosis
Study type: Interventional

Summary: 
      Background: In the present study, we aimed to evaluate the effect of regular Schroth
      exercises on pulmonary functions in adolescent idiopathic scoliosis (AIS) patients who use
      rigid braces and perform Schroth exercises regularly.

      Objective: The main purpose of this study, is to investigate the effects of Schroth exercises
      on pulmonary functions in adolescents who use rigid braces and perform Schroth exercises
      regularly.

      Methods: Twenty-four patients with AIS were included in the study. The patients who wore
      rigid braces and performed the SSE therapy constituted the "Brace&Exercise" (N=12), and the
      patients who wore full-time rigid braces but did not perform exercise constituted the "Brace
      Group" (N=12) of the study. The effects of Schroth exercises on pulmonary functions were
      measured at the beginning of treatment and the 8th week of the treatment.

      Keywords: Adolescent, idiopathic scoliosis, conservative treatment, brace, respiratory
      function, Schroth exercises.
    


Intervention name(s): Brace and Exercise Treatment; Brace Treatment
Intervention type(s): Other; Other
Intervention description(s): Schroth exercises, which are a specific exercise method for scoliosis, were given to the experimental group for 8 weeks, different from the control group.; Among the patients included in the study, those who wore braces but did not agree to exercise constituted the ''Brace Group'' of the study.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effectiveness of Haptic Technology in Teaching Urinary Catheterization Skill
Condition: Educational Problems
Study type: Interventional

Summary: 
      Background: Haptic systems represent the highest level of computer based education
      technologies and enable students to learn at the highest level. These applications increase
      the student's focus as well as making the education non-monotonous and insuring teaching
      permanent by ensuring the active participation of the student.

      Objective: The study was conducted to determine the effectiveness of using haptic technology
      in teaching urinary catheter application skill on the level of success and satisfaction about
      this skill.
    

Detailed description: 
      Method: This randomized-controlled experimental study was conducted with nursing students
      registered at a public university between December 2018 and March 2019. The sample of the
      study included 78 second grade students who gave consent after being informed about the aim
      of the study and who met the inclusion criteria. Control (n=39) and experimental (n=39)
      groups were determined through randomization using simple numbers table. Urinary
      catheterization application skill was taught with the standard curriculum (demonstration on
      the model) to the control group while it was taught with haptic-controlled computer based
      simulation technology to the experimental group. Data were collected using "Structured
      Student Introduction Form," "Skill Checklist for Teaching Urinary Catheterization Skill" and
      "Questionnaire for Satisfaction with Training Methods."
    

Intervention name(s): 3D Systems Touch Haptic Simulator
Intervention type(s): Device
Intervention description(s): This simulator is computer-aided and allows us to see this application on the computer screen while practicing with a haptic arm. It gives real-like feedback in hand manipulations. The simulator has a choice of 45 minutes of full instruction, 5 minutes of haptic arm only, or the option.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The study is designed in a randomized controlled experimental type.
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Haptic education technology; Computer based simulation; Nursing education
Real World Data Study Assessing The Persistency Of Xalacom And The Other Fixed Dose Combination Products, Duotrav And Ganfort, In The United Kingdom
Condition: Glaucoma; Ocular Hypertension
MeSH terms: Ocular Hypertension
Study type: Observational

Summary: 
      The hypothesis is that there is no difference in persistency between Xalacom and the
      alternative fixed dose combination products (Duotrav and Ganfort) over a 12 month period.
    


Intervention name(s): XALACOM; Duotrav; Ganfort
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Xalacom eye drops; Duotrav eye drops; Ganfort eye drops
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        patients who had received a prescription for either Xalacom, Ganfort and DuoTrav, > 18
        years old, diagnosed with glaucoma or ocular hypertension, registered at the primary care
        practice for > 12 months
      
Keywords: Real world; observational; retrospective; database analysis
Study of Efficacy and Safety LMF237 in Patients With Type 2 Diabetes Mellitus (T2DM) Inadequately Controlled With Vildagliptin Monotherapy
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of the study was to evaluate the efficacy and safety of LMF237 50/250 mg and
      50/500 mg bid in Japanese patients with T2DM inadequately controlled with vildagliptin
      monotherapy. This study was conducted to support registration of the fixed-dose combination
      of vildagliptin and metformin for the treatment of T2DM in Japan.
    


Intervention name(s): LMF237 50/250 mg; LMF237 50/500 mg; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Corresponds to vildagliptin 50 mg twice daily and metformin 250 mg twice daily; Corresponds to vildagliptin 50 mg twice daily and metformin 500 mg twice daily; Matching placebo of LMF237 (contained vildagliptin 50 mg as active ingredient) twice daily
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Hysteroscopic vs. Cervical Injection for Sentinel Node Detection of Endometrial Cancer
Condition: Endometrial Cancer
MeSH terms: Endometrial Neoplasms
Study type: Interventional

Summary: 
      Hysteroscopic vs. Cervical Injection for Sentinel Node Detection of Endometrial Cancer: a
      multicenter prospective randomized study
    

Detailed description: 
      Hysteroscopic vs. Cervical Injection for Sentinel Node Detection of Endometrial Cancer
    

Intervention name(s): Hysteroscopic injection; Cervical injection
Intervention type(s): Procedure; Procedure
Intervention description(s): Hysteroscopic injection; Cervical injection
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Cervical injection; Hysteroscopic injection
Reaction Time in Digital Game Players
Condition: Computer Games
Study type: Observational

Summary: 
      With the increasing use of computers in recent years, the effects of games have started to be
      discussed. Young people who play computers are exposed to many stimuli during the game and
      they react to these stimuli with reactions at various rates. In our study, we wanted to find
      out whether there is a significant difference in reaction time between young people who play
      computers more than 14 hours a week and those who do not.
    

Detailed description: 
      While doing our research, the reaction time test in the Human Benchmark application, where
      the reaction time to many different stimuli on the computer can be evaluated, the Aim Trainer
      test and the auditory reaction time tests at https://playback.fm/audio-reaction-time will be
      applied. The way the tests are applied; the first test will be separated as a trial and will
      not be included in the average. The next three tests will be averaged. Height, weight,
      smoking, use of antidepressants or stimulants, any ear or hearing problems, any eye disease,
      how many days a week and how much sports they do, the dominant side, whether they play
      digital and video games, for how long, what type of device (computer, tablet, phone), which
      games (League of legends, Player unknown's battlegrounds, World of Warcraft, Valorant, FIFA,
      PES, Call of duty, NBA, Counter strike:Global offensive CS:GO, other), how many hours a day
      and how many hours a week they play digital video games will be questioned whether they
      participate in the tournament with at least one of these games.
    

Intervention name(s): Reaction Time Tests
Intervention type(s): Diagnostic Test
Intervention description(s): While doing our research, the reaction time test in the Human Benchmark application, where the reaction time to many different stimuli on the computer can be evaluated, the Aim Trainer test and the auditory reaction time tests at https://playback.fm/audio-reaction-time will be applied.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        male individuals aged between 18-25 years who have been playing digital games for more than
        2 years
      
Keywords: digital game players; reaction time
Finasteride Treatment of Severe Nodulocystic Acne
Condition: NODULOCYSTIC ACNE
MeSH terms: Acne Vulgaris
Study type: Interventional
Phase: Phase 2

Summary: 
      Double-blind, randomized, placebo-controlled, dose-ranging study to evaluate the efficacy and
      safety of once weekly, high dose oral finasteride compared to placebo for the treatment of
      severe nodulocystic acne in male subjects.
    

Detailed description: 
      There will be 180 male subjects in this study. The study is composed of a Screening Period of
      up to 30 days during which inclusion / exclusion criteria will be reviewed, screening
      laboratory results will be obtained and medication washouts will be done as required.
      Subjects will complete the sexual function questionnaire and depression scale. A one day
      Baseline Period (Day 0), during which baseline assessments of acne lesion counts, physical
      examination and Investigator's Global Assessment Scale will be done. The Baseline Period will
      be followed by a 12-week randomized double-blind Treatment Period, in which subjects will be
      randomized into Finasteride 23.5 mg group, 33.5 mg group, or placebo group. During the
      Treatment Period, subjects will visit the study site Day 14, Day 28, and Day 56 for acne
      lesion counts and review of diaries, concomitant medications and adverse events. On Day 84
      subjects will return to clinic for acne lesion counts and review of diaries, concomitant
      medications, adverse events and remaining study drug will be counted and collected. A
      physical exam and vital signs, Investigator Global Assessment, Subject Assessment of
      Efficacy, depression scale and sexual function questionnaire will be completed before the
      subject is discharged from the study.
    

Intervention name(s): Finasteride 23.5 mg tablets; Finasteride 33.5 mg tablets; Placebo tablets
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: Finasteride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: acne; nodulocystic; finasteride; 5 alpha reductase inhibitor
Trial to Evaluate the Safety and the Immunogenicity of GSK Biologicals' Influenza Vaccine GSK2186877A in Healthy Children
Condition: Influenza
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the safety and immunogenicity of GlaxoSmithKline
      Biologicals' influenza vaccine GSK2186877A in healthy children 6 to 35 months of age.

      This Protocol Posting has been updated following Amendment 1 of the Protocol, Jun 2010. The
      impacted sections are study design, outcome measures, intervention sections and number of
      subjects.
    


Intervention name(s): Influenza vaccine GSK2186877A formulation 1; Influenza vaccine GSK2186877A formulation 2; Fluarix
Intervention type(s): Biological; Biological; Biological
Intervention description(s): Intramuscular administration, 2 doses; Intramuscular administration, 1 dose; Intramuscular administration, 1 dose
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Children; Influenza; Safety; Immunogenicity; Vaccine
The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL
Condition: Chronic Lymphocytic Leukemia (CLL)
MeSH terms: Leukemia, Lymphocytic, Chronic, B-Cell
Study type: Interventional
Phase: Phase 4

Summary: 
      Patients with chronic lymphocytic leukemia (CLL)have had very poor humoral responses to
      pneumococcal polysaccharide vaccine (PPV). The vaccine in which pneumococcal polysaccharide
      antigens are conjugated to protein (PCV) have been immunogenic in CLL patients in our
      previous studies.

      The purpose of this study is to evaluate the duration of these vaccine-induced antibodies and
      the function of memory cells by giving a one dose of PPV-vaccine after several years of
      PCV-vaccination.
    


Intervention name(s): Pneumococcal polysaccharide vaccine (PPV)
Intervention type(s): Biological
Intervention description(s): One intramuscular injection
Intervention MeSH terms: Heptavalent Pneumococcal Conjugate Vaccine
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: CLL; PPV; PCV
A Study of CS3005 in Advanced Solid Tumors
Condition: Advanced Solid Tumor
MeSH terms: Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      A Phase I, Multi-center, Open-label, Dose Escalation Study of CS3005 in Subjects with
      Advanced Solid Tumors
    


Intervention name(s): CS3005
Intervention type(s): Drug
Intervention description(s): CS3005 will be orally administrated twice daily (BID) until PD, unacceptable toxicity, withdrawal of informed consent, or until maximum treatment duration per protocol (2 years)
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Long-term Safety and Efficacy Outcome Study Comparing Children Previously Enrolled in Study ROPP-2008-01 for the Prevention of Retinopathy of Prematurity (ROP)
Condition: Retinopathy of Prematurity (ROP)
MeSH terms: Retinal Diseases; Retinopathy of Prematurity; Premature Birth
Study type: Interventional
Phase: Phase 2

Summary: 
      The main purpose of this study is to evaluate the long-term efficacy and safety outcomes
      following short-term exposure to rhIGF-1/rhIGFBP-3 versus standard neonatal care in Study
      ROPP-2008-01 (NCT01096784).
    

Detailed description: 
      Long-term Safety and Efficacy Outcome Study Comparing Children Previously Enrolled in Study
      ROPP-2008-01 for the Prevention of Retinopathy of Prematurity (ROP)
    

Intervention name(s): rhIGF-1/rhIGFBP-3
Intervention type(s): Drug
Intervention description(s): Participants who received "rhIGF-1/rhIGFBP-3" in study ROPP-2008-01 (NCT01096784) will be enrolled to this study. No investigational product will be administered in this study.
Other intervention name(s): Mecasermin rinfabate
Intervention MeSH terms: Mecasermin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Novel Catheter Lock Solution for Treatment of Tunneled Hemodialysis Catheter-Associated Bacteremia
Condition: End-Stage Renal Disease; Hemodialysis Catheter-associated Infection
MeSH terms: Bacteremia; Catheter-Related Infections; Kidney Failure, Chronic
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective is to investigate the ability of systemic intravenous antibiotic plus
      antibiotic/anti-biofilm (i.e. N-acetylcysteine) lock catheter technique in eradicating
      uncomplicated catheter associated bacteremia and salvaging the infected vascular catheter.
      Secondary objectives include duration to clearance of bacteremia, future recurrence of
      bacteremia, need for catheter removal and death.
    


Intervention name(s): catheter lock solution consisting of N-acetylcystein, tigecycline and heparin
Intervention type(s): Drug
Intervention description(s): N-acetylcystein 80 mg/ml, tigecycline 1 mg/ml, and heparin 2000 units/ml. This will be a 5 ml catheter lock solution
Intervention MeSH terms: Tigecycline; Heparin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: biofilm; catheter lock solution; catheter salvage
Gardasil Knowledge
Condition: HPV
Study type: Observational

Summary: 
      Human papillomavirus (HPV) is the most common viral genital tract infection. The majority of
      women and men who are sexually active will be exposed to a strain or strains of the virus.
      While there are hundreds of viral strains, high risk strains are associated cervical and oral
      cancers. According to the Centers for Disease Control (CDC), between 2008 and 2012 there were
      38,793 deaths attributed to HPV related cancers. Vaccinations were created in an attempt to
      prevent infection from the most common high risks strains of HPV. Gardasil/HPV-9 was created
      to help prevent HPV related cancers and warts. The HPV-9 vaccine includes protection from 7
      strains of HPV associated with 74% of HPV related cancers. While Gardasil was approved and
      released in 2006, many men and women have not been vaccinated. A national immunization survey
      in 2011 of teens 13-17 years old noted that only 60% of girls and 40% of boys have received
      at least one vaccination in the series. While complete vaccination series is recommended, a
      recent study found that a single dose of Gardasil when compared to placebo created a higher
      level of serum antibodies in uninfected females.
    

Detailed description: 
      All patients seen at a single clinic will be offered participation in the anonymous survey.
      The survey will ask a series of questions regarding basic demographics, sexual history,
      smoking status, and Gardasil vaccine knowledge. The survey will serve as evidence of the
      vaccine utility by highlighting patient risk factors for HPV and patient knowledge about the
      vaccine series.
    

Intervention name(s): Gardasil
Intervention type(s): Other
Intervention description(s): None-data gathering only
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Females age 18-26 of all ethnic background
BATHE Method on Preoperative Anxiety, Patient Satisfaction and Individual Anesthesia Concerns
Condition: Anesthesia; Reaction; Anxiety Preoperative; Patient Satisfaction
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      In this study the goal is to determine the causes of concern among the patients who will
      undergo surgical operations and receive general anesthesia, to gauge their preoperative
      anxiety levels and to study the effects of the BATHE method on preoperative anxiety and
      patient satisfaction.
    

Detailed description: 
      In this study the goal is to determine the causes of concern among the patients who will
      undergo surgical operations and receive general anesthesia, to gauge their preoperative
      anxiety levels and to study the effects of the BATHE method on preoperative anxiety and
      patient satisfaction.

      500 patients who were planned to undergo elective surgery and under general anesthesia as
      anesthesia method were included in the study. Demographic data of patients, their three
      biggest fears of anesthesia and APAIS scores were recorded. The patients were divided into
      two groups, they underwent BATHE anamnesis or standard anamnesis methods according to their
      groups, then their APAIS and patient satisfaction scores were recorded.
    

Intervention name(s): Bathe anamnesis method; standart anamnesis
Intervention type(s): Other; Other
Intervention description(s): BATHE anamnesis (BA) is applied to first group and preoperative examinations are completed.; standart anamnesis is applied to second group and preoperative examinations are completed.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Screening
Keywords: preoperative anxiety; anesthesia anxiety; BATHE method; APAIS; patient satisfaction
Dermacyd PH_DETINBACK (Lactic Acid) Sweet Flower - Safety.
Condition: Hygiene
Study type: Interventional
Phase: Phase 3

Summary: 
      To prove the safety in normal conditions of use.
    


Intervention name(s): Dermacyd PH_DETINBACK (Lactic Acid) Sweet Flower
Intervention type(s): Drug
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care