Vaccination Coverage and Level of Protection in Patients at Risk
Condition: Diabetes; Chronic Kidney Disease; Allergy; Cystic Fibrosis; Heart Disease
MeSH terms: Cystic Fibrosis; Kidney Diseases; Renal Insufficiency, Chronic; Heart Diseases
Study type: Observational

Summary: 
      The purpose of this study is to determine

        1. vaccination coverage of recommended vaccines (routine childhood vaccines and vaccines
           against seasonal flu and pneumococci) in children with chronic diseases (allergy, cystic
           fibrosis, diabetes mellitus type 1, congenital heart disease, immunocompromised and
           solid organ transplant patients)

        2. the level of protection against measles, mumps, rubella and pertussis in children with
           chronic diseases.

        3. vaccination coverage of recommended vaccines (diphtheria, tetanus, pertussis and
           vaccines against seasonal flu and pneumococci) in adults with chronic diseases
           (nephropathy, diabetes mellitus, COPD, heart failure, HIV and solid organ transplant
           patients)

        4. the level of protection against diphtheria, tetanus and pertussis in adults with chronic
           diseases.
    

Detailed description: 
      1. Chronically ill children

           1.1 What is the vaccination status for vaccines recommended by the Superior Health
           Council in pediatric chronically ill patients (2-16 years of age) who consult within the
           University hospital of Leuven?

           Patients with one of the following chronic conditions will be included:

             -  Cystic fibrosis

             -  Diabetes Mellitus type 1

             -  Allergic constitution

             -  Congenital heart disease

             -  Solid-organ transplantpatients

             -  Immunodeficiency (congenital or acquired)

             -  Cancer

           The vaccination coverage for the following vaccines will be determined:

             -  Poliomyelitis

             -  Diphtheria

             -  Tetanus

             -  Pertussis

             -  Haemophilus influenzae type b

             -  Hepatitis B

             -  Measles-Mumps-Rubella

             -  Pneumococci

             -  Meningococcal serogroup C

             -  Rotavirus

             -  Diphtheria-Tetanus-Polio: booster (older than 7 years)

             -  Human papillomavirus (girls of 13 yrs)

             -  Seasonal flu (cystic fibrosis, immunodeficiencies)

           Timeliness of the vaccines given will also be determined.

           1.2 Is the vaccination coverage of pediatric patients (2-16 years of age) comparable to
           the data on healthy children in 2012?

           1.3 What are possible factors that influence coverage in this specific patient
           populations?

           1.4 If the vaccination coverage is too low (below 90-95 percent), what are possbile
           solutions to increase the coverage rates within this group?

           1.5. Determine antibody titers in this same population for the following
           vaccine-preventable infectious diseases:

             -  Measles

             -  Mumps

             -  Rubella

             -  Pertussis

           1.6 Are antibody titers in this population similar to antibody titers measured in
           seroprevalence studies of healthy children in the same age group?

        2. Adult patients at risk

      2.1 What is the vaccinatiestatus for vaccines recommended by the Superior Health Council of
      adult patients at risk (over 18 years of age) who consult within the University hospital of
      Leuven?

      Patients with one or more of the following chronic conditions will be included in the study:

        -  Chronic obstructive pulmonary disease (COPD)

        -  Heart failure

        -  Diabetes mellitus (Type 1 and 2)

        -  Chronic kidney disease (stadium IV and V)

        -  Solid organ Transplant patients

        -  HIV

        -  HSCT

      The vaccination coverage for the following vaccines will be determined:

        -  Seasonal flu (yearly)

        -  Diphtheria-tetanus (date of last dose)

        -  Pneumococcus (1 dose/last dose before 5 years of age)

        -  Pertussis (1 dose)

        -  Hepatitis B (3 doses in specific risk groups)

      2.2 Who immunizes these adult patients at risk?

      2.3 What are possible risk factors who influences vaccination status in the adult population?

      2.4 If the vaccination coverage is too low (below 90-95 percent), what are possible solutions
      to improve this coverage in these groups?

      2.5 What are the antibody titers measured in the adult risk groups with a chronic condition
      for the following vaccine-preventable infectious diseases:

        -  Diphtheria

        -  Tetanus

        -  Pertussis

      2.6 Are antibody titers measured in this population comparable to those of healthy subjects
      as measured in previous seroprevalence studies?
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Chronically ill patients (pediatric and adult) in follow-up at the University Hospital
        Leuven, Belgium
      
Biospecimen description: 
      Serum samples