bioihbjkbjnl/mcl2 huggingface dataset:
Reciprocal Inhibition Versus Reciprocal Facilitation In Spinal Cord Injury Patients
Condition: Spinal Cord Injuries
MeSH terms: Spinal Cord Injuries
Study type: Interventional

Summary: 
      Reciprocal inhibition is a medulla spinalis control mechanism that facilitates motor
      activities in healthy people. As the agonist muscle contracts, the antagonist muscle is
      inhibited so that the agonist action can take place properly. In the literature, there are
      studies showing that in patients with upper motor neuron lesions, this reverses, and
      reciprocal facilitation occurs instead of inhibition. However, there is no clear situation in
      this regard, there is a need for more methodologically sound studies. Our aim in this study
      is to investigate the presence of reciprocal facilitation in patients with spinal cord
      lesions (SCL).
    

Detailed description: 
      Reciprocal inhibition is a spinal segmental control mechanism that facilitates motor
      activities in healthy people and is also used in treating spasticity. Considering the current
      literature, there are some studies claiming that this is reversed in patients with upper
      motor neuron lesions and that there is reciprocal facilitation instead of inhibition.
      However, the proposed evidence is not convincing. Our aim in this study was to investigate
      the presence of reciprocal facilitation in detail in patients with upper motor neuron
      lesions. This study was conducted in five patients with spinal cord lesions and five healthy
      individuals. Both the tibialis anterior and soleus muscles of the cases were recorded using
      surface and multi-motor unit electromyography (EMG) electrodes. To elicit an H reflex in the
      soleus muscle, an electric current was delivered through the popliteal fossa using the
      monopolar technique. The Achilles tendon was tapped with the reflex hammer to elicit a T
      reflex. Since the H-reflex and T-reflex responses were detected in the tibialis anterior
      muscle surface and multi-motor unit EMG recordings, the findings were evaluated as direct
      stimulation, cross-talk, and reciprocal facilitation. Methodologically, This research aimed
      to be a guiding study for future studies.
    

Intervention name(s): Tendon tap; Tibial nerve stimulation
Intervention type(s): Diagnostic Test; Diagnostic Test
Intervention description(s): While examining the T reflex, the ankle was held passively in neutral, dorsiflexion and plantar flexion positions by the investigator.; H-reflex responses were examined by tibial nerve stimulation
Other intervention name(s): T-reflex; H-reflex
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: Group I. Spinal cord injuries Group II. Healthy Control
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Spinal Cord; motor neuron; Spasticity
Quality of Life Following Gastric Bypass Surgery.
Condition: Obesity
Study type: Observational

Summary: 
      A central goal of health care is to maximize patient functioning and well-being. This has
      prompted measurement of health-related quality of life (HRQOL) that encompasses physical,
      psychological, and social functioning. While obese people have generally impaired HRQOL,
      people seeking bariatric surgery for obesity appear to have poorer HRQOL than obese
      individuals seeking non-surgical treatment or obese individuals not seeking weight-loss
      treatment. HRQOL improves significantly after bariatric surgery, but often with large
      individual variations in outcome. As gastric bypass is an invasive procedure with
      irreversible influences on eating behaviour and possible serious adverse events, it is
      important to identify potential risk factors for a poorer long-term result. In Denmark,
      bariatric surgery is free of charge for patients fulfilling the Danish Health and Medicines
      Authority guidelines, which until 2011 were in line with international guidelines. However,
      in 2011 access to surgery was dramatically restricted and the annual number of operations
      reduced from 0.9 per 1000 inhabitants (2010) to 0.2 per 1000 inhabitants (2012). The
      restrictions involved a tightening of the criteria for patients without manifest obesity
      comorbidities, raising lower body mass index (BMI) threshold from 40 to 50 and increasing the
      lower age limit from 18 to 25 years (11). It is not known whether patients fulfilling the
      tighter criteria benefit more from surgery than patients who only met the previous criteria.

      This study assessed HRQOL changes associated with Roux-en-Y gastric bypass with follow-up
      over an average of 22 months. The aim was to explore whether postoperative HRQOL variations
      were associated with identifiable socio-demographic or clinical characteristics. In
      particular, whether HRQOL changes differed for patients fulfilling the current Danish
      criteria and patients only fulfilling the previous criteria.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients treated with Roux -en-Y gastric bypass surgery in 2008-2010 i Region of Southern
        Denmark.
      
Keywords: Gastric bypass; Health-related quality of life; SF-36; Questionnaire; Treatment guidelines
Comparison of Dysport Reconstitution at 1.5 mL and 2.5 mL for the Treatment of Moderate to Severe Glabellar Lines
Condition: Glabellar Lines; Wrinkles
Study type: Interventional
Phase: Phase 4

Summary: 
      This study is designed to evaluate the safety, efficacy, and subject and investigator
      satisfaction of 2 different injection volumes of Dysport in the glabellar lines.

        1. To determine the proportion of composite responders (based on blinded evaluator and
           subject assessments) who achieve at least a 1-point reduction from baseline in glabellar
           line severity score (GLSS) at maximum frown line on Day 30.

        2. To assess the GLSS, at maximum frown and at rest, by live assessment at all visits.

        3. To evaluate the onset of effect on appearance of glabellar lines starting at the Day 2
           visit (subject and blinded evaluator).

        4. To assess the subject's satisfaction with the treatment.

        5. To evaluate investigator satisfaction of treatment outcome.

        6. To evaluate subject psychological well-being.

        7. To evaluate subject age appraisal.

        8. To evaluate all adverse events during the course of the study.
    

Detailed description: 
      Five month, randomized, subject- and evaluator-blinded, multi-center, mult-visit study.
      Subjects treated with Dysport following the US on-label guidelines.
    

Intervention name(s): Dysport reconstituted at 1.5 mL (0.05 mL/injection); Dysport reconstituted at 2.5 mL (0.08 mL/injection)
Intervention type(s): Device; Device
Intervention description(s): Subjects treated for moderate to severe (GLSS = 2 or 3) glabellar lines at maximum frown.; Subjects treated for moderate to severe (GLSS = 2 or 3) glabellar lines at maximum frown.
Intervention MeSH terms: abobotulinumtoxinA; Botulinum Toxins, Type A
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
A Study Comparing Imatinib and Imatinib/Pegylated Interferon in Chronic Myeloid Leukemia
Condition: Health Care Quality; Health Care Evaluation
MeSH terms: Leukemia; Leukemia, Myeloid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Study type: Interventional
Phase: Phase 2

Summary: 
      Patients with chronic myeloid leukemia in imatinib induced CHR are randomized between
      imatinib 400 mg daily and imatinib 400 mg daily + PegIntron 30 ug weekly.

      Primary endpoint: To compare at 12 months between the treatment arms the rate of Major
      Molecular Response (=99,9% tumour reduction) at 12 months
    

Detailed description: 
      130 patients registered, 112 randomized. 56 pats in each treatment arm. 12 months study
      duration. Rate of Major Molecular Response was at 12 months 53 vs 82 % (p=0.002) in favour of
      the combination arm.
    

Intervention name(s): imatinib and pegylated interferon
Intervention type(s): Drug
Intervention description(s): imatinib 400 mg p.o. daily pegylated interferon 50 ug s.c. weekly
Other intervention name(s): Gleevec; PegIntron
Intervention MeSH terms: Interferons; Imatinib Mesylate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Chronic myeloid leukemia, imatinib, interferon
Magnetic Prefrontal Stimulation for Studying the Role of the Cortex in High-level Cognition Processes and Reward System
Condition: Healthy Volunteers
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The investigators intend to study the role of the cortex in high- level cognition processes
      and sensory adaptation, by the use of non-invasive Transcranial Magnetic stimulation and
      various cognitive tests.
    


Intervention name(s): TMS
Intervention type(s): Device
Intervention description(s): TRANSCRANIAL MAGNETIC STIMULATION
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: reward; TMS; cognition; Motivation; Perception; Decision making
A Comparison Between Sonoguided Injection Corticosteroid and Hyaluronic Acid Injection in Treatment of Trigger Finger
Condition: Trigger Finger
MeSH terms: Trigger Finger Disorder
Study type: Interventional

Summary: 
      The study is to compare the effect between steroid injection and Hyaluronic acid in treatment
      trigger finger. Using sonoguided injection technique achieves more accurate injection
      location and therapeutic effect. We hypothesize hyaluronic acid has both lubricant and
      anti-inflammation effect in treatment of trigger finger, and can provide better outcome and
      lower adverse effect than steroid injection.
    

Detailed description: 
      This is a prospective, randomized, double-blinded controlled study. Patients with the
      diagnosis of trigger finger will be recruited and enrolled from Taipei Veteran General
      Hospital PM&R outpatient clinic. Subjects will be randomized into two groups; hyaluronic acid
      and triamcinolone acetonide injections, both via ultrasound-guided with one injection only.We
      hypothesize that through the anti-inflammatory property of the hyaluronate acid, the
      treatment effects will be as effective as the traditionally used steroid injections with
      equal or even lower recurrence rate for treatment of trigger finger. We expect that
      injections of hyaluronate into tendon sheath could become a new treatment option for trigger
      finger.
    

Intervention name(s): triamcinolone acetonide; Hyaluronic Acid
Intervention type(s): Drug; Drug
Intervention description(s): used ultrasound-guided inject 1c.c triamcinolone acetonide 10mg/mL (Shincort®, YSP, Taiwan)into the sheath of the flexor tendons, penetrated to the A1 pulley.
One injection only Steroid; used ultrasound-guided inject 1c.c Hyaluronic acid (Artz®, Seikagaku, Japan)into the sheath of the flexor tendons, penetrated to the A1 pulley.
One injection only
Other intervention name(s): triamcinolone acetonide 10mg/mL (Shincort®, YSP, Taiwan); Hyaluronic acid (Artz®, Seikagaku, Japan)
Intervention MeSH terms: Triamcinolone; Triamcinolone Acetonide; Triamcinolone hexacetonide; Hyaluronic Acid; Triamcinolone diacetate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Hyaluronic acid, trigger finger
Low Energy Dense, Weight Maintenance, Risk of Cardiovascular Disease
Condition: Body Weight Decreased
MeSH terms: Body Weight
Study type: Interventional
Phase: Phase 3

Summary: 
      Investigators presumed that low energy density (LED) diet consumers will have lower risk of
      cardiovascular disease and are able to maintain their weight longer .
    

Detailed description: 
      Previous studies introduced different dietary interventions for weight loss maintenance.
      Besides the debate on low fat or low carbohydrate diets, focusing on some food groups
      including fruits, vegetables and low fat dairies in the diet may be helpful for weight
      maintenance. However, energy intake is the key factor of weight maintenance. Energy intake
      will decrease by reducing energy density (ED) of a diet without producing short-term calorie
      restriction or feeling hunger. There are several studies which showed the beneficial effects
      of low energy density diets on weight reduction. However, few studies discuses regarding the
      effects of such diets on weight maintenance.
    

Intervention name(s): low energy dense; control; diet
Intervention type(s): Other; Other; Other
Intervention description(s): This group received a diet appropriate with their weight in the form of low energy density diet; This group received a diet appropriate with their weight in the form of an usual diet regarding the energy density.; Calorie requirements of each subject were estimated based on resting energy expenditure (by the use of Harris-Benedict equation) and physical activity levels.
Other intervention name(s): LED; usual; low energy dense; control
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Health Services Research
Keywords: overweight; obesity; low energy dense
Minimal Water Exchange Versus Left Water Exchange in Unsedated Colonoscopy
Condition: Water Exchange Colonoscopy
Study type: Interventional

Summary: 
      Minimal water exchange colonoscopy is theoretically more convenient and faster than water
      exchange colonoscopy. But few studies compared the differences between the two methods.
      Therefore, we attempted to evaluate the effect of minimal water exchange colonoscopy
      prospectively.
    


Intervention name(s): minimal water exchange
Intervention type(s): Other
Intervention description(s): Use a new technique, minimal water exchange colonoscopy, which adds the infusion of modest amounts of water by constant pressure on the air-water valve button of the endoscope to achieve intubation.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: water-aided colonoscopy
Teh Effect of Subgingival Irrigation Wif Ketorolac and Chlorhexidine in Patients Wif Chronic Periodontist
Condition: Chronic Periodontitis
MeSH terms: Periodontitis; Chronic Periodontitis
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      In this study, 40 patients with a history of Mild- Periodontitis who were diagnosed with
      clinical and radiographic findings showed that all of the periodontal parameters before the
      treatment, during the treatment period Then, scaling & Root planing and oral hygiene
      instructions were given to the patients, and after 2 weeks, the patients who received the
      study were randomly divided into two groups (Balanced Block Randomization) with four blocks
      according to the visit time. To group A, oral chlorohexidine and to B group, the drug
      Ketorolac was given. 5 mm of the drugs required every 15 days the areas underwent a gingival
      wash with an insulin syringe, which lasted for 3 months.
    

Detailed description: 
      In this study, 40 patients with a history of Mild- Periodontitis who were diagnosed with
      clinical and radiographic findings showed that all of the periodontal parameters before the
      treatment, during the treatment period Then, scaling & Root planing and oral hygiene
      instructions were given to the patients, and after 2 weeks, the patients who received the
      study were randomly divided into two groups (Balanced Block Randomization) with four blocks
      according to the visit time. To group A, oral chlorohexidine (Ghol Darou-Tehran) and to B
      group, the drug Ketorolac (Exir-Boroujerd) was given. 5 mm of the drugs required every 15
      days the areas underwent a gingival wash with an insulin syringe, which lasted for 3 months.
      Pl, BI, PD were evaluated in the study sessions. At the end of the clinical change, a
      multiple measure ANOVA test was used to compare the preceding and follow-up sessions in both
      groups, considering the intervention method as Between subject comparison And measured at the
      time of measurement as a Repeated Factor.
    

Intervention name(s): Ketorolac; Chlorhexidine 2%
Intervention type(s): Drug; Drug
Intervention description(s): Ketorolac 3% topical subgingival irrigation was put into the periodontal pocket using an insulin syringe; Chlorhexidine 2% topical subgingival irrigation was put into the periodontal pocket using an insulin syringe
Other intervention name(s): Group A; Group B
Intervention MeSH terms: Chlorhexidine; Ketorolac
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: split mouth
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Botulinum Toxin Type A (AGN-151607) for the Prevention of Post-operative Atrial Fibrillation in Adult Participants Undergoing Open-chest Cardiac Surgery (NOVA)
Condition: Post-Operative Atrial Fibrillation
MeSH terms: Atrial Fibrillation
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a multi-center, randomized, double-blind, placebo-controlled, parallel group,
      dose-ranging study to evaluate the efficacy and safety of botulinum toxin type A (AGN-151607)
      injections into the epicardial fat pads, foci of ganglionic plexi, to prevent Post-Operative
      Atrial Fibrillation (POAF) in patients undergoing open-chest cardiac surgery.
    


Intervention name(s): AGN-151607; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Injections will be made into each 1 of 5 fat pads. The total injection volume into each fat pad will be 1 mL. One-time treatment.; Injections of placebo will be made into each 1 of 5 fat pads. The total injection volume into each fat pad will be 1 mL. One-time treatment.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Decreasing Rates of Intraurethral Catheterization Postoperatively in Spine Surgery
Condition: Post-operative Urinary Retention
MeSH terms: Urinary Retention
Study type: Interventional
Phase: Phase 4

Summary: 
      Randomization (1:1) of male patients, over age 50, undergoing elective spine surgery to
      tamsulosin versus a placebo.
    

Detailed description: 
      Postoperative urinary retention (POUR) is a common complication following certain surgical
      operations. While much is known about the innervation and neural regulation of bladder
      emptying and storage, the cause of urinary retention after surgery is not fully understood.
      Early research has indicated that a small dose of tamsulosin (Flomax®), a commonly used
      medication approved to treat urinary symptoms in men with benign prostatic hypertrophy, may
      reduce the incidence of POUR. Urinary retention is a prevalent issue in patients undergoing
      spinal surgery, leading to patient discomfort and prolonged length of stay. We hypothesize
      that the use of perioperative tamsulosin in patients undergoing spinal surgery will decrease
      the incidence of POUR.

      The study is a prospective, double-blind, randomized, placebo-controlled trial. Subjects will
      be randomized 1:1 to receive either oral tamsulosin 0.4 mg or placebo, taken once each
      evening, beginning 5 days prior to surgery and continuing through the first postoperative
      day. The primary endpoint is met when the patient is able to spontaneously empty their
      bladder post-operatively, or needs to be catheterized with either a straight or indwelling
      urinary catheter for post-operative urinary retention, whichever occurs first.
    

Intervention name(s): Tamsulosin; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Active drug; Lactose-filled capsules identical to active drug
Other intervention name(s): Flomax; Flomaxtra; Contiflo XL; Urimax
Intervention MeSH terms: Tamsulosin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Prevention
Generic Tazarotene Cream, 0.1% in the Treatment of Acne Vulgaris
Condition: Acne Vulgaris
MeSH terms: Acne Vulgaris
Study type: Interventional
Phase: Phase 3

Summary: 
      To compare the safety and efficacy profiles of Tazarotene Cream, 0.1 % to the reference
      listed drug Tazorac® (tazarotene) Cream, 0.1 % in order to demonstrate bioequivalence, and to
      demonstrate superiority of the 2 active creams over that of the cream vehicle (placebo) in
      the treatment of acne vulgaris.
    

Detailed description: 
      This is a randomized, placebo-controlled, parallel-group, multicenter, double-blind study of
      Tazarotene Cream, 0.1% in subjects with acne vulgaris. Subjects will be assigned in a 1:1:1
      ratio to test product, reference product, or cream vehicle. Subjects will be admitted into
      the study only after written informed consent has been obtained and all of the inclusion and
      none of the exclusion criteria have been met. Randomized subjects will apply the study
      medication once daily in the evening for 12 weeks (84 days).
    

Intervention name(s): Vehicle; Tazarotene Cream, 0.1 %; Tazorac Cream, 0.1%
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Cream Vehicle (placebo) (G & W Laboratories, Inc.)- vehicle; Tazarotene Cream, 0.1 % (G & W Laboratories, Inc.) - test product; Tazorac Cream, 0.1% (Allergan, Inc.) - reference product
Other intervention name(s): Placebo; Active; Reference Listed Drug
Intervention MeSH terms: Tazarotene
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
RECO Flow Restoration Device Versus Solitaire FR With the Intention for Thrombectomy Study
Condition: Ischemic Stroke
MeSH terms: Ischemic Stroke
Study type: Interventional

Summary: 
      Endovascular therapy is increasingly used for patients with moderate-to-severe acute ischemic
      stroke.This study will compare the efficacy and safety of RECO(a novel, self-expanding stent
      retriever) with Solitaire FR within 8 hours of stroke onset caused by the large vessel
      occlusion.
    

Detailed description: 
      RECO is a novel, self-expanding stent retriever, designed to yield rapid flow restoration in
      acute cerebral ischaemia. The proposed study is a multicenter, randomized, prospective,
      parallel-group, open-label clinical trial with a blinded outcome, to test the RECO(a novel,
      self-expanding stent retriever), as compared with Solitaire FR stent retriever.
    

Intervention name(s): RECO flow restoration device; Solitaire FR flow restoration device
Intervention type(s): Device; Device
Intervention description(s): RECO flow restoration device is a novel, self-expanding stent retriever designed to yield rapid flow restoration in acute cerebral ischaemia.; Solitaire FR flow restoration device has been approved by the FDA and CFDA.
Other intervention name(s): RECO; Solitaire FR
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: acute ischemic stroke,endovascular recanalization; mechanical thrombectomy