bioihbjkbjnl/mcl2 huggingface dataset:
Transcriptomic Profile of Endometrium in Different Histological Dating of Hormone Replacement Cycle
Condition: Infertility, Female
MeSH terms: Infertility; Infertility, Female
Study type: Interventional

Summary: 
      At present, the evaluation criterion of endometrial receptivity is controversial. The
      development of a molecular diagnostic tool, the endometrial receptivity array (ERA) for
      diagnosis of endometrial receptivity . But use of this test in patients with RIF has shown
      that the window of implantation (WOI) is displaced in only a quarter of these patients and
      use of a personalized embryo transfer (pET) on the day designated by ERA improves
      reproductive performance with higher cost .what is known to the others'population? The
      morphological changes observed on histology for each specific day after ovulation were
      described by Noyes and his colleagues in 1950 . An endometrial biopsy that shows a difference
      of more than 2 days between the histologic dating and actual day after ovulation is
      considered to be ''out of phase''. But such pET studies according to the Noyes criterion in
      hormone replacement cycle are lacking . The aim of this study is to explore the
      transcriptomic profile of endometrial receptivity in different histological dating of hormone
      replacement cycle and its clinical application.
    


Intervention name(s): personal embryo transfer
Intervention type(s): Procedure
Intervention description(s): According to the histological dating and transcriptomic profile of endometrium of hormone replacement cycle in control group, to explore the effectiveness of intervention by advanced or delayed personal embryo transfer . The establishment of standard control group: Frozen embryo transfer patients according to the inclusion and exclusion criteria were evaluated for histological dating and transcriptomic profile by endometrial biopsy on day P＋7 in an HRT cycle. After routine time transfer in the frozen embryo transfer cycle, the standard of histological dating and transcriptomic profile were determined according to the pregnancy outcome of the FET cycle .
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Influence of Shunt Occlusion on Organ Functions in Hyperammonemic Patients With Cirrhosis Having Porto-systemic Shunt.
Condition: Cirrhosis
MeSH terms: Liver Cirrhosis; Fibrosis
Study type: Interventional

Summary: 
      The spontaneous Porto-systemic shunt is occluded by intervention procedures like Balloon
      Occluded Retrograde Transvenous Obliteration (BRTO), Plug-assisted Retrograde Transvenous
      Obliteration (PARTO) and shunt occlusion procedures resulting in diversion of blood flow
      towards the portal circulation and in turn the liver. According to this investigator
      hypothesized that shunt occlusion improves liver volume and function along with beneficial
      effect on other organ systems by decreasing ammonia and improving hepatopetal flow. All
      patients with cirrhosis having large shunt(>10mm) and raised ammonia levels and will be
      randomized to receive standard medical treatment and those receiving shunt occlusion
      procedures. Investigator will assess organ functions and liver regenerative potential pre and
      post (after 3 to 15 months) procedure.
    


Intervention name(s): Shunt Occlusion; Standard Medical Treatment (SMT)
Intervention type(s): Procedure; Dietary Supplement
Intervention description(s): Catheterization of the Porto-systemic shunt (via the left renal vein for gastro-lienorenal shunt) will be accomplished using a catheter and occlusion will be performed with balloon catheter/vascular plug. Occlusion venography is then performed to define the type of varix/varices and the anatomy of the venous drainage followed by infusion of sclerosant. The occluded balloon were inflated and remained in place for a maximum of 24 hours deflated under fluoroscopy the next day/plug is deployed and sclerosant is injected to obliterate the shunt and follow up CT is done to look for completion on the next day. Follow up CT abdomen is done periodically to look for effect on shunt and organ.; These will include diet rich in BCAA (branch chain amino acids), laxatives and rifaximin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Platelet-rich Plasma (PRP) Injection for Treatment of Erectile Function
Condition: Erectile Dysfunction Due to Arterial Insufficiency
MeSH terms: Erectile Dysfunction
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      The primary objective of the present study is to investigate and compare the treatment
      efficacy of PRP injection vs placebo treatment in men with mild-moderate vasculogenic ED, as
      measured by IIEF.The secondary objective of the present clinical trial is to study the
      adverse events and safety of the PRP injection treatment in vasculogenic ED patients
    


Intervention name(s): Platelet-Rich Plasma (PRP); Normal saline injection
Intervention type(s): Biological; Biological
Intervention description(s): All subjects of this group will receive 2 sessions of PRP penile injection with 30 +/- 3 day treatment interval, 10 ml of PRP will be injected at each session.; All subjects of this group will receive 2 sessions of normal saline penile injection with 30 +/- 3 day treatment interval for all subjects, 10 ml of normal saline will be injected at each session.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: PRP; Platelet-Rich Plasma
A Pilot Study of Mirabegron and Behavioral Modification Including Pelvic Floor Exercise for Overactive Bladder in Parkinson's Disease (MAESTRO)
Condition: Parkinsons Disease
MeSH terms: Parkinson Disease; Urinary Bladder, Overactive
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to see if the study drug, Mirabegron, is safe and effective in
      treating symptoms of Overactive Bladder in people with Parkinson's Disease.
    

Detailed description: 
      This study is a randomized 1:1 placebo-controlled 10-week study of Mirabegron as add-on
      therapy to an educational intervention of behavioral modification including pelvic floor
      exercise (PFE) in a cohort of 40 Parkinson's subjects over the age of 30 with overactive
      bladder (OAB). Active drug will be Mirabegron 25 mg daily with up-titration to 50 mg daily
      after 5 weeks. Subjects will be enrolled based on response to an overactive bladder
      questionnaire at visit 2.

      Enrolled subjects will have 4 study visits to the clinic as well as 2 phone visits.

      Enrolled subjects will be asked to record urinary symptoms and pelvic floor exercises in a
      diary at 3 separate time points for a 72 hour period.
    

Intervention name(s): Mirabegron; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 25 mg po daily for 32-40 days. Following up-titration to 50 mg po daily. This is pending no adverse events on the 25 mg dose.; Placebo 25 mg po daily. Following up-titration to 50 mg po daily. This is pending no adverse events on the 25 mg dose.
Other intervention name(s): Mirabetriq; sugar pill
Intervention MeSH terms: Mirabegron
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Postoperative Skin Surface Tension Relaxing in Prevention of Facial Surgical Skin Scarring
Condition: Scar
MeSH terms: Cicatrix
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the efficacy and safety of early postoperative skin
      surface reduction in improving scar formation after facial surgery.
    

Detailed description: 
      Primary measurement: the mean scar width calculated by standard photos with rulers.

      Secondary measure: the probability of scar hyperplasia.
    

Intervention name(s): Tension reduction device
Intervention type(s): Device
Intervention description(s): Continue using this device for 3 months post surgery.
Other intervention name(s): Zipline Surgical Skin Closure Device
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: Tension Reduction
Safety, Tolerability and Immunogenicity of Two Different Formulations of Meningococcal B Recombinant Vaccine, When Administered to Healthy Infants
Condition: Meningococcal Disease
MeSH terms: Meningococcal Infections
Study type: Interventional
Phase: Phase 2

Summary: 
      To explore safety, Tolerability and immunogenicity of two formulations of a Meningococcal B
      Recombinant Vaccine when administered to healthy infants.
    


Intervention name(s): rMenB; rMenB+OMV
Intervention type(s): Biological; Biological
Intervention description(s): One dose (0.5 mL) of rMenB vaccine without OMV-NZ supplied as a full liquid formulation in a prefilled syringe was administered into the anterolateral area of the right thigh.; One dose (0.5 mL) of rMenB vaccine with OMV-NZ supplied as a full liquid formulation in a prefilled syringe was administered into the anterolateral area of the right thigh.
Other intervention name(s): Serogroup B meningococcal recombinant vaccine without OMV-NZ; Serogroup B meningococcal recombinant vaccine with OMV-NZ
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Meningococcal disease, prevention, vaccination
Optimizing tDCS Protocol for Clinical Use in Major Depressive Disorder
Condition: Depressive Disorder; Cognitive Impairment; Psychiatric Disorder
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major; Mental Disorders; Problem Behavior
Study type: Interventional

Summary: 
      In this project, the efficacy of different tDCS protocols in major depression will be
      investigated. The tDCS protocols have already been investigated in humans, and results showed
      that stimulation intensity has a different effect on tDCS long-term aftereffects based on the
      human motor cortex model. The project has three major goals: first, we want to see if the
      differential outcome of tDCS dosage, as present in healthy populations, can be translated to
      patients with major depression. Second, we want to compare the efficacy of a multi-channel
      novel protocol with conventional tDCS modules. Lastly, we are interested in the safety and
      tolerability of optimized multi-channel. The project output will be an optimized tDCS
      protocol for major depression treatment.
    


Intervention name(s): transcranial direct current stimulation (tDCS); multichannel transcranial direct current stimulation (tDCS)
Intervention type(s): Device; Device
Intervention description(s): In tDCS, direct electrical currents at the intensity of interest (2 mA for example) are generated by an electrical stimulator and are noninvasively delivered to the scalp through a pair of saline-soaked sponge electrodes (7×5 cm) or via more than two but smaller round electrodes over the target regions.; In multichannel tDCS, direct electrical currents at the intensity of interest (2 mA for example) are generated by an electrical stimulator and are noninvasively delivered to the scalp through more than two and smaller round electrodes over the target regions.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: randomized, double-blind, parallel group trial
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Keywords: major depressive disorder; tDCS
A Pilot Study to Assess Treatment of Patients With Homogeneous Emphysema Using Sequential Segmental Bronchoscopic Thermal Vapor Ablation (NEXT STEP)
Condition: Emphysema or COPD
MeSH terms: Pulmonary Emphysema; Emphysema
Study type: Interventional

Summary: 
      This study is a Prospective, single arm, single center pilot study following outcomes for 12
      months after initial BTVA treatment. The primary objectives of the study are to prospectively
      document the safety and efficacy of sequential segmental treatment with BTVA in patients with
      a homogeneous distribution of emphysema that are not candidates for endobronchial valve
      therapy.
    

Detailed description: 
      The study will include patients with severe emphysema as defined by pulmonary function tests,
      a homogeneous distribution of emphysema as determined by CT, who are not eligible for
      endobronchial valve therapy based on fissure integrity as determined by CT. Enrollment will
      continue until 10 patients have been treated per protocol or until a maximum of 15 patients
      total have been treated.

      Patients will be enrolled at Thoraxklinik University of Heidelberg, Germany and followed for
      twelve (12) months.

      The follow up data collected will include pulmonary function testing (spirometry, body
      plethysmography, DLCO), exercise capacity (six minute walk test) and imaging findings (chest
      x-ray and CT). Dyspnea score (mMRC) and quality of life questionnaire (SGRQ-C) information
      will be obtained. Information regarding adverse events, serious adverse events, and major
      medical complications will be collected at each visit. Serious adverse events will be
      adjudicated by an independent medical monitor in order to establish relatedness to the
      InterVapor device and procedure.

      Descriptive statistics will be used to summarize all safety and efficacy data. There is no
      predefined hypothesis regarding safety, or efficacy.

      Monitoring of the study will be undertaken as a continuous process to ensure that
      high-quality data are obtained and to ensure compliance with study procedures.
    

Intervention name(s): Bronchoscopic Thermal Vapor Ablation (BTVA)
Intervention type(s): Device
Intervention description(s): Bronchoscopic vapor delivery to airway segment(s) targeted for treatment
Other intervention name(s): BTVA; InterVapor
Intervention model: Single Group Assignment
Intervention model description: Single arm Pilot Study
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: COPD, Emphysema, Homogenous, Collateral Ventilation; Vapor; Ablation
The STOP-HPV Trial 1: Communication Intervention
Condition: Immunization; Vaccination
Study type: Interventional

Summary: 
      Most adolescents who receive human papillomavirus (HPV) vaccine are vaccinated in pediatric
      practices, yet missed opportunities (MOs) for HPV vaccination occur often and lead to low HPV
      vaccination rates. This cluster randomized clinical trial (RCT) will test the effectiveness
      (and cost-effectiveness) of training providers on HPV vaccine communication to reduce MOs and
      increase HPV vaccination rates.
    

Detailed description: 
      As highlighted by NCI, low HPV vaccination rates represent a major lost opportunity for
      population-wide cancer prevention. Pediatric primary care office visits are the main site for
      HPV vaccination, yet many missed opportunities (MOs) for vaccination occur in primary care
      and contribute to low vaccination rates. MOs are office visits during which a patient is
      eligible for a vaccine, but does not receive it. Many factors cause MOs - provider factors
      (e.g., time-constrained visits, lack of communication skills, and giving vaccinations only at
      preventive visits) and parent factors (e.g., vaccine hesitancy). This cluster randomized
      clinical trial will test the effectiveness (and cost-effectiveness) of training providers in
      HPV vaccine communication to reduce MOs and increase HPV vaccination rates. This training
      will be done through online educational modules (sent via text or email), weekly mini lessons
      and live office practice sessions.
    

Intervention name(s): STOP-HPV communication intervention
Intervention type(s): Behavioral
Intervention description(s): This intervention will be communication skills training.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: This study will use a cluster RCT study design to test the impact of the communication intervention to reduce missed opportunities (MOs) and raise HPV vaccine rates
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: HPV; Vaccination; Practice based intervention
Electrophysiologic Changes in Blacks Treated With CBT for Insomnia
Condition: Insomnia
MeSH terms: Sleep Initiation and Maintenance Disorders
Study type: Interventional

Summary: 
      Insomnia is a highly prevalent, often debilitating, and economically burdensome condition.
      Reviews of the literature indicate that there are ethnic differences in sleep behavior, with
      African Americans objectively and subjectively reporting more disordered sleep than Caucasian
      Americans.Chronic insomnia can have a significant impact on mental and physical health
      outcomes and has been associated with impaired cognitive performance, particularly, in areas
      of speed, attention, working memory, and executive function. In order to understand the brain
      mechanisms in sleep disorder both during resting state as well as during cognitive
      processing, the investigators will assess resting state EEG (during eyes-closed and eyes-open
      conditions) as well as ERP tasks for assessing decision-making and reward processing. The
      primary objective of the study is to evaluate the effect of a tailored, telephone-delivered
      cognitive behavioral intervention, versus a self- monitoring control condition, on symptoms
      of insomnia and its neurodynamic correlates.

      Hypotheses: Among Blacks subjectively reporting symptoms of insomnia, those randomized to the
      tailored, telephone-delivered CBT-I, compared with those randomized to the self-monitoring
      control group, will have: Hyp. 1: Greater reduction in symptoms of insomnia as measured by
      the Pittsburgh Sleep Quality Index. Hyp. 2: Greater neurophysiologic improvement (ERP, ERO)
      in the intervention condition in response to laboratory paradigms Hyp 3: Greater improvement
      in psychosocial functioning including reduction in depression and increase in quality of
      life.
    


Intervention name(s): Cognitive Behavioral Therapy for Insomnia (CBT-I); Self-Monitoring
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Cognitive-behavioral therapy is a short-term, focused psychotherapy for a wide range of psychological and behavioral issues including depression, anxiety, anger, and non-compliance. The focus of the intervention is on how one thinks, behaves, and communicates in real time, as opposed to a focus on one's early childhood experiences. The therapist assists the patient in identifying specific distortions and biases in thinking and provides guidance on how to modify these beliefs. CBT helps the patient learn effective self-help skills that are used in homework assignments that ultimately help change the way one thinks, feels and behaves. The
￼ intervention is action-oriented, practical, rational, and helps the patient gain independence and effectiveness in dealing with real-life issues. Techniques utilized in CBT-I include psychoeducation, sleep hygiene, cognitive restructuring, stimulus control, sleep restriction, and relaxation training.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Dural Puncture Epidural Technique Versus Conventional Epidural Techmique
Condition: Gynecologic Disease Requiring Laparoscopic Hysterectomy Under Neuraxial Anesthesia
MeSH terms: Genital Diseases, Female
Study type: Interventional

Summary: 
      This study will be conducted on 50 patients of ASA grade I and II aged from 25 to 55 years
      and presented for laparoscopic hysterectomy. Patients will be divided into two equal groups;
      group A control group for conventional epidural technique(n=25) and group B for 25G dural
      puncture epidural with 25G pencil point Whitacre spinal needle (n=25). Randomization will be
      done using computer generated number and concealed using sequentially numbered, sealed opaque
      envelope.
    


Intervention name(s): Conventional Epidural Technique; Dural Puncture Epidural Technique using pencil-point 25G Whitacre needle
Intervention type(s): Procedure; Procedure
Intervention description(s): Standard Lumbar Epidural Block using Touhy Epidural Needle (18G) at L2-3 inter-space and Epidural Catheter (20G) was inserted then bupivacaine 0.5% 15-20 ml with 50ug fentanyl was given.; 25G Dural Puncture Epidural Block at L2-3 inter-space then bupivacaine 0.5% 15-20 ml with 50ug fentanyl was given.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Threshold Inspiratory Trainer Versus Trigger Sensitivity Adjustment on Weaning From Mechanical Ventilation
Condition: Respiratory Failure
MeSH terms: Respiratory Insufficiency
Study type: Interventional

Summary: 
      Ninety adult patients from both gender, with acute respiratory failure, intubated and
      mechanically ventilated. Their ages ranged from 50 to 70 years. They were selected from
      Intensive Care Unit (ICU), Department of Chest Diseases, Cairo University Hospitals. They
      have randomly assigned into three equal groups. Group (A): trained by threshold IMT device
      plus routine physical therapy. Group (B): trained by adjusting MV trigger sensitivity plus
      routine physical therapy. Group (C): only received routine physical therapy. (Negative
      inspiratory force NIF, arterial blood gases, P/F ration, respiratory rate RR, tidal volume
      VT, and rapid shallow breathing index RSBI) were measured before the study and at the end of
      the study (just before weaning for successfully weaned patients, or on the 10 day of
      intervention for failed weaning patients).
    


Intervention name(s): Threshold inspiratory muscle trainer device; Adjusting mechanical ventilator trigger sensitivity; Chest physiotherapy
Intervention type(s): Other; Other; Other
Intervention description(s): The threshold inspiratory muscle trainer (IMT) device offers resistance to respiration through the spring-loaded valve.; modifying the mechanical ventilator trigger sensitivity so that patients can only initiate inspiratory flow by producing more negative intrathoracic pressure; Conventional chest physiotherapy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Supportive Care