Doxycycline in the Treatment of Aggressive Periodontitis
Condition: Aggressive Periodontitis
MeSH terms: Periodontitis; Aggressive Periodontitis; Aggression
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The aim of the study was to compare the clinical effects of systemic use of doxycycline to
      amoxicillin plus metronidazole as adjunctive treatment in nonsurgical debridement of
      aggressive periodontitis (AgP). Twenty four patients with aggressive periodontitis were
      enrolled in this clinical study. They all received oral hygiene instruction and full-mouth
      nonsurgical debridement using manual instruments. The test group received as adjunctive
      antibiotic treatment 200 mg of doxycycline the first day followed by 100 mg per day during 14
      days. The control group received 500 of amoxicillin and 250 of metronidazole, three times a
      day for 7 days.
    

Detailed description: 
      This comparative clinical study was conducted in the department of Periodontology, Center for
      Dental Consultation and Treatment (CDCT), Rabat, Morocco.

      Prior to participation, the purpose of the investigation was fully explained to all
      participants and written informed consent was obtained from all patients. The study protocol
      was approved by the biomedical ethical committee of University Mohammed V in Rabat, Morocco,
      and conducted according to the principles outlined in the Declaration of Helsinki on
      experimentation involving human subjects.

      Patients : Twenty four subjects diagnosed with localized (LAgP) or generalized aggressive
      periodontitis (GAgP) (8 patients with LAgP and 16 with GAgP) were enrolled in the study.
      Patients were aged between 16 and 26 years and were from both genders (22 female and 2
      male).The diagnosis was based on the classification of the American Academy of Periodontology
      (AAP).

      Clinical variables were pocket depth, plaque index, gingival index

      At the end of the debridement sessions, patients were assigned doxycycline or the amoxicillin
      plus metronidazole regardless the type of AgP. So that, experimental group of patients were
      administered 200 mg of doxycycline the first day followed by 100 mg per day for 14 days, and
      the control group were administered 250 mg of metronidazole and 500 mg of amoxicillin, three
      times a day for 7 days.

      Data analysis The data were analyzed using the patient as a unit (subject based analysis).
      The statistical analysis was performed with a statistical program (SPSS Inc., Chicago, IL,
      USA). The improvement of periodontal status was evaluated by calculating, for each patient,
      the difference in Plaque Index (DIP), gingival index (DIG) and probing depth (DPD) ≥ 4mm,
      between baseline and 3 months post treatment. For each patient, the quantitative variables
      (PI, GI, and MPD) were expressed as medians and quartiles and were compared before and after
      treatment using the Wilcoxon test. Improved plaque index (DIP), gingival index (DIG), and
      probing depth (DPD ≥ 4mm) was compared between the two groups (doxycycline and amoxicillin
      plus metronidazole) using the Mann-Whitney test. A level P<0,05 was accepted for statistical
      significance.
    

Intervention name(s): amoxicillin plus metronidazole; Doxycycline
Intervention type(s): Drug; Drug
Intervention description(s): patients were administered 250 mg of Flagyl and 500 mg of Dyspamox, three times a day for 7 days; patients were administered 200 mg of Longamycine the first day and 100 mg per day for 14 days
Other intervention name(s): Dispamox and Flagyl; Longamycine
Intervention MeSH terms: Amoxicillin; Metronidazole; Doxycycline
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: aggressive periodontitis; systemic antibiotics; doxycycline