Nebulized Versus Intravenous Magnesium Sulfate in Treatment of Asthma Exacerbation
Condition: Asthma Attack
MeSH terms: Asthma
Study type: Observational

Summary: 
      A prospective study in Beni-Seuf University Hospital that was conducted on 123 adult patients
      with acute asthma exacerbations. Patients were classified into group (I): received IV
      magnesium sulfate, group (II): received nebulized magnesium sulfate, and group (III): control
      group. Blood pressure, respiratory rate, pulse, peak expiratory flow rate (PEFR) measurement
      using a peak flowmeter, Fischl index and need for hospitalization in patients with acute
      bronchial asthma were done for all patients before treatment, immediately after the
      treatment, "30", and "60" min after treatment.
    

Detailed description: 
      Inclusion criteria :

        -  adult patients between the ages of 18 and 50 years with acute attack of bronchial asthma

        -  from both sexes

        -  Normal renal function

        -  Normal cardiovascular function

      Exclusion criteria:

        -  Patients were younger than 18 years or older than 50 years.

        -  Patients suffered from chronic obstructive pulmonary disease, renal disorder and heart
           failure

      All patients were subjected to: complete history taking, blood sampling for serum magnesium
      measurement (on admission before the initial treatment and after the initial treatment) the
      patients were randomly separated into 3 equal groups each group consists of 41 patients.

      The 1ST group has been managed by an initial treatment plan (consists of supplemental oxygen
      therapy to keep oxygen saturation higher than 90%., nebulization of 1 ml salbutamol
      respirator solution mixed with 9 ml normal saline solution for one session [Farcolin
      respirator solution: each 20 ml of Farcolin contains Salbutamol sulfate 0.121 gm. Made in
      Egypt, by: Pharco Pharmaceuticals -Alexandria], Intravenous administration of hydrocortisone
      100 mg for a single dose [Solu-Cortef: vial contains powder of 100 mg Sodium hydrocortisone
      sodium succinate dissolved with 2 ml solvent of sterile bacteriostatic water for IV
      injection. Manufactured by: Egyptian Int. Pharmaceutical Industries co. (e.i.p.i.co.) -
      Egypt. Under license of: Pfizer]) plus a single dose (2000 mg) of magnesium sulfate prepared
      by mixing 20 ml of 10 % magnesium sulfate (2000 MG) [14] ,manufactured by Memphis
      Pharmaceuticals and Chemical Industries, with 30 ml of distillated water for injection to
      produce 50 ml of isotonic magnesium sulfate solution (324 MSOM/L) administered intravenously
      over 1 hour.

      The 2nd group has been managed by the same initial treatment plan plus a single dose (2000
      mg) of magnesium sulfate prepared by mixing 20 ml of 10 % magnesium sulfate (2000 MG) [14]
      ,manufactured by Memphis Pharmaceuticals and Chemical Industries, with 30 ml of distillated
      water to produce 50 ml of isotonic magnesium sulfate solution (324 MSOM/L). nebulized using
      jet nebulizer over 1 hour.

      The 3rd group has been managed by the same treatment plan Without using magnesium sulfate. (a
      control group) the following were recorded for each patient at a fixed interval (before the
      initial treatment, immediately after the initial treatment, 30, and 60 min after the initial
      treatment):

        1. blood pressure, respiratory rate and pulse rate

        2. Peak expiratory flow measurement using peak flow meter.

        3. Fischl index for relapse and need for hospitalization in patients with acute bronchial
           asthma. [16[ .
    

Intervention name(s): Magnesium sulfate
Intervention type(s): Drug
Intervention description(s): Blood pressure, respiratory rate, pulse, peak expiratory flow rate (PEFR) measurement using a peak flowmeter, Fischl index and need for hospitalization in patients with acute bronchial asthma were done
Intervention MeSH terms: Magnesium Sulfate
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        131 patients were included in the study.Eight subjects were excluded due to presence of
        heart failure or renal failure.