Strategies to Reduce Iron Deficiency
Condition: Iron Deficiency
MeSH terms: Anemia, Iron-Deficiency; Iron Deficiencies
Study type: Interventional

Summary: 
      The prevalence of iron deficiency in blood donors has been demonstrated to be a direct
      consequence of repeat blood donations. Given the adverse effects of iron deficiency, it is
      priority to implement programs to remediate iron deficiency issues associated with blood
      donations. To explore this issue, the study's aims to:

        1. Determine whether regular blood donors provided with accurate information about their
           iron status and written recommended courses of action will take steps to
           prevent/mitigate iron deficiency on their own without being given iron supplements by
           the blood center; and

        2. Determine if two different amounts of iron provided by the blood center will
           prevent/mitigate iron deficiency in regular blood donors.

      To conduct this randomized, placebo controlled study, participant donors will be assigned to
      one of two arms and followed for a 24 month period. Each subject will provide additional
      blood samples of 7 ml and 4.5 ml at each study visit for the purpose of tracking hemoglobin
      (Hgb), ferritin, soluble transferrin receptor (sTfR), and hematology laboratory results.

      Under the two study arms, subjects are to be randomized into one of the following five
      blinded categories:

        -  Receive a thank you letter after each blood donation.

        -  Receive a letter informing them of their ferritin result at each visit, along with
           recommendations for blood donation.

        -  Receive pills to take daily that contain no iron (a placebo or inert pill).

        -  Receive pills to take daily that contain 19 mg of iron (the typical amount in a
           multivitamin with iron).

        -  Receive pills to take daily that contain 38 mg iron (the typical amount in an
           over-the-counter iron supplement).
    

Detailed description: 
      Inclusion Criteria

        -  Donors who have donated whole blood or double red cells ≥ 2 times in the last 12 months
           if female, or, ≥ 3 times in the last 12 months if male.

        -  Commitment to meet the donation frequency requirement for the study for two more years,
           give a blood sample at each visit, and complete baseline and follow-up surveys.

      Exclusion Criteria

        -  Subjects < 18 years of age.

        -  Subjects taking iron supplements (including multivitamins with iron) up to one month
           prior to enrollment.

        -  Females who are pregnant or plan to become pregnant in the following 2 years.

        -  Subjects unwilling to meet the requirements of the study.
    

Intervention name(s): Ferrous gluconate- 19 mg; Ferrous gluconate- 38 mg; Letter Group- Information Provided; Letter - No Information Provided; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement; Other; Other; Dietary Supplement
Intervention description(s): Receive pills to take daily that contain 19 mg of iron (the typical amount in a multivitamin with iron).; Receive pills to take daily that contain 38 mg iron (the typical amount in an over-the-counter iron supplement).; Receive a letter informing them of their ferritin result at each visit, along with recommendations for blood donation.; Receive a letter thanking the participant for their participation.; Receive pills to take daily that contain 0 mg iron.
Intervention MeSH terms: Ferrous gluconate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: hemoglobin recovery; iron recovery; iron supplements