bioihbjkbjnl/mcl2 huggingface dataset:
Efficacy of Therapeutic Exercise vs. Treatment of Myofascial Trigger Points.
Condition: Shoulder Tendinopathy
MeSH terms: Tendinopathy
Study type: Interventional

Summary: 
      Background: Shoulder pain commonly affects the general population, with rotator cuff
      tendinopathy being the most common cause.

      the most common cause, with rotator cuff tendinopathy diminishing function and quality of
      life, leading to a major socio-economic impact.

      quality of life, leading to a major socio-economic impact. As a result, there are two
      treatment approaches with potential effectiveness: therapeutic exercise (TE) and myofascial
      trigger point treatment (TMT).

      trigger point treatment (TTP).

      Objective: The main objective of this randomised clinical trial is to determine the efficacy
      of ET versus treatment of MTPs in shoulder tendinopathies.

      Methods: For this study, 20 participants were randomly divided into two groups: a ET group,
      with which a 10-exercise programme was initiated (n = 10), and a PGM group which was given an
      intervention protocol (n = 10).

      intervention protocol (n = 10). Both received a total of 10 sessions. Pain intensity pain
      intensity, pressure pain threshold (PPT) and range of motion (ROM) were assessed before
      starting and after 10 sessions.

      and after 10 sessions.
    


Intervention name(s): trigger point therapy; Exercise therapy
Intervention type(s): Procedure; Procedure
Intervention description(s): patients who have been treated for shoulder tendinopathy by trigger point therapy; patients who have been treated for shoulder tendinopathy by exercise therapy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: shoulder tendinopathy; supraspinatus; infraspinatus; physiotherapy techniques; therapeutic exercise; trigger points
19F MRI to Evaluate Regional Ventilation in Healthy Subjects and Subjects With Cystic Fibrosis
Condition: Cystic Fibrosis
MeSH terms: Cystic Fibrosis; Fibrosis
Study type: Interventional
Phase: Early Phase 1

Summary: 
      An open label non-randomized study enrolling up to 20 healthy participants and up to 30
      participants with cystic fibrosis to establish a healthy versus disease comparison. Each
      participant will receive a mixture of inert gas (perfluoropropane (PFP)) in a ratio of 79%
      PFP to 21% oxygen as a contrast agent to enhance visualization of the airway and alveolar
      spaces using magnetic resonance imaging of inert gas/oxygen mixtures. The study consists of a
      screening visit followed by up to 2 study visits.
    

Detailed description: 
      The goal of this study is to evaluate the ability of conventional 'thermally' polarized
      perfluorinated gases (19F) mixed with oxygen to detect changes in ventilation using magnetic
      resonance imaging (MRI). A secondary goal is to assess the repeatability and the
      within-subject variability of these findings in CF lung disease. This is an open label pilot
      study expanding on work by other investigators currently using this technique in human
      subjects. Projection images using controlled breathing techniques will be obtained using 19F
      MRI, correlating spirometric variables with regional distribution of the gases.
    

Intervention name(s): PFP
Intervention type(s): Drug
Intervention description(s): Composition: inhaled PFP, a gaseous contrast agent (79% PFP, 21% O2, pre-mixed, medical grade gas)
Administration: Full-face disposable ventilation mask and a standard Douglas Bag system.
Dosage: Two controlled breaths of contrast gas followed by a full breath and a 12-second breath-hold and scan for image acquisition.
Frequency: Repeated 5 times followed by an identical five cycles with room air to ensure PFP gas wash-out has occurred.
Other intervention name(s): Perfluoropropane gas (C3F8); 19F
Intervention model: Single Group Assignment
Intervention model description: This study enrolls both healthy volunteers and volunteers with cystic fibrosis. Both healthy and CF participants will receive the same treatment throughout the entirety of the study.
Masking: None (Open Label)
Primary purpose: Other
Keywords: Lung; Imaging; Hyperpolarized; Perfluorinated; MRI
Music and Premenstrual Symptoms and Quality of Life
Condition: MUSIC THERAPY; Premenstrual Syndrome
MeSH terms: Premenstrual Syndrome
Study type: Interventional

Summary: 
      Premenstrual syndrome is an important health problem affecting women of childbearing age.
      This study is a prospective, single-blinded randomized controlled trial. Participants were
      randomized into music, and control groups. Immediately post-intervention, the women in the
      experimental groups had significantly higher reduce premenstraul syndrome levels and increase
      a quality life.
    

Detailed description: 
      Premenstrual syndrome is an important health problem affecting women of childbearing age.
      This study aimed to show that music medicine can be used to reduce premenstrual syndrome
      levels and increase quality of life. This study is A prospective, single-blinded randomized
      controlled trial. The study was conducted between January and April 2021 with 97 women who
      are college students. Participants consisted of women over 20 years of age and with have
      premenstraul snydrome. Participants were randomized into music, and control groups.
      Immediately post-intervention, the women in the experimental groups had a significantly
      higher reduce premenstraul syndrome levels and increase a quality life. Each method (music
      and control group) is evaluated for The Premenstrual Syndrome Scale and Short form of the
      WHOQOL-BREF.
    

Intervention name(s): music medicine
Intervention type(s): Other
Intervention description(s): To reduce premenstrual symptoms by applying music medicine to people with premenstrual syndrome
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized controlled clinical trial
Masking: Double (Participant, Care Provider)
Primary purpose: Supportive Care
Keywords: Premenstrual syndrome; music medicine; quality life; midwife; nurse
Efficacy, Safety and Tolerability of Romosozumab in the Treatment of Japanese Women With Postmenopausal Osteoporosis
Condition: Postmenopausal Osteoporosis (PMO)
MeSH terms: Osteoporosis; Osteoporosis, Postmenopausal
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine if treatment with romosozumab increases bone
      mineral density in Japanese women with postmenopausal osteoporosis.
    


Intervention name(s): Romosozumab; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Administered by subcutaneous injection; Administered by subcutaneous injection
Other intervention name(s): AMG 785; EVENITY™
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Osteoporosis, Osteoporosis-Postmenopausal, Bone Diseases-Metabolic, Bone Diseases, Musculoskeletal Diseases
Evaluate Safety and Biological Activity of ATYR1940 in Participants With Early Onset Facioscapulohumeral Muscular Dystrophy
Condition: Facioscapulohumeral Muscular Dystrophy (FSHD)
MeSH terms: Muscular Dystrophies; Muscular Dystrophy, Facioscapulohumeral
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The purpose of this study is to assess the safety and biological activity of ATYR1940 in
      participants with early onset FSHD.
    

Detailed description: 
      A Phase 1b/2 open-label, intraparticipant dose-escalation study aiming to evaluate the
      safety, tolerability, immunogenicity, biological and pharmacodynamic activity of intravenous
      ATYR1940, administered once weekly for 12 weeks, in early onset FSHD participants with signs
      or symptoms prior to 10 years of age.
    

Intervention name(s): ATYR1940
Intervention type(s): Biological
Intervention description(s): Concentrate for solution for infusion
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: FSHD
Placebo and Active Controlled Study to Assess Efficacy and Tolerability of Aspirin Plus Pseudoephedrine
Condition: Common Cold; Pharyngitis
MeSH terms: Common Cold; Pharyngitis
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is compare efficacy and tolerability of a fixed combination,
      containing 500 mg Acetylsalicylic acid and 30 mg Pseudoephedrine, in comparison to its single
      components in patients with sore throat and nasal congestion.
    


Intervention name(s): Acetylsalicylic Acid (Aspirin Complex, BAYE4465) + Pseudoephedrine; Acetylsalicylic Acid (Aspirin, BAYE4465); Pseudoephedrine; Placebo
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Single oral dose of 1 to 2 Aspirin Complex sachets, each containing granules of 500 mg Acetylsalicylic Acid (ASA) and 30 mg Pseudoephedrine (PSE), to be taken orally after dissolving in a glass of water; to be repeated as needed every 6 hours for a period of not more than 3 days.; Single oral dose of 1 to 2 sachets Acetylsalicylic Acid, each containing granules of 500 mg Acetylsalicylic Acid (ASA), to be taken orally after dissolving in a glass of water; to be repeated as needed every 6 hours for a period of not more than 3 days.; Single oral dose of 1 to 2 sachets Pseudoephedrine, each containing granules 30 mg Pseudoephedrine, to be taken orally after dissolving in a glass of water; to be repeated as needed every 6 hours for a period of not more than 3 days.; Single oral dose of 1 to 2 sachets, each containing Placebo granules, to be taken orally after dissolving in a glass of water; to be repeated as needed every 6 hours for a period of not more than 3 days.
Intervention MeSH terms: Aspirin; Pseudoephedrine; Ephedrine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Sore Throat; Upper Respiratory Tract Infections; Nasal Congestion
Xeloda and Bevacizumab to Treat Rectal Cancer
Condition: Rectal Cancer
MeSH terms: Rectal Neoplasms
Study type: Interventional
Phase: Phase 2

Summary: 
      The project objective is to evaluate the efficacy of the neoadjuvant treatment with
      bevacizumab, capecitabine and radiotherapy, in patients with rectal adenocarcinoma resectable
      locally advanced (stage T3 or T4), with or without presence of ganglionar metastases and
      without distant metastases.
    


Intervention name(s): Bevacizumab; capecitabine (Xeloda); Rectal Radiotherapy
Intervention type(s): Biological; Drug; Radiation
Intervention description(s): Bevacizumab 4 cycles each 15 days, the first 10 mg/kg and the rest of cycles with 5 mg/kg.; Capecitabine 900 mg/m2 two times a day concomitant during radiotherapy period; Radiotherapy in rectum 45 Gy starting on Bevacizumab 2nd cycle during 5 weeks, 1.8 Gy per day, 5 days at week.
Intervention MeSH terms: Bevacizumab; Capecitabine
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: rectum; adenocarcinoma; neoadjuvant; bevacizumab; capecitabine; radiotherapy; locally; advanced; resectable; resectable locally advanced adenocarcinoma of the rectum; xeberecto
Exploring Immunosuppressant Medication Adherence in Kidney Transplant Patients
Condition: Adherence, Medication; Transplantation, Kidney
Study type: Observational

Summary: 
      To describe the beliefs, understanding and experience of immunosuppressant medication
      adherence in our current transplant patient population through a series of patient focus
      groups
    

Detailed description: 
      The investigators want to understand more about why some of our kidney transplant patients
      find it difficult to take their anti-rejection medicines as intended. It is hoped that if the
      investigators can improve their understanding of why some patients struggle with their
      anti-rejection medicines, the investigators will be able to find better ways to help our
      transplant patients and so fewer patients may develop problems with their transplant. This
      study will collect qualitative data from a series of focus groups with kidney transplant
      recipients to explore their beliefs, understanding and experience of anti-rejection
      medication adherence. The focus groups will also explore the support that participants have
      received to help them with their medication adherence and what support they feel should be
      available to them and to others in the future to optimise anti-rejection medication adherence
      in transplant patients. Five focus groups will be undertaken. Each focus group will include
      six patients and will last for approximately 1.5 hours. All participants will be kidney
      transplant recipients transplanted and followed up at Imperial College Renal and Transplant
      Centre.
    

Intervention name(s): Focus group
Intervention type(s): Behavioral
Intervention description(s): Kidneys transplant patients will discuss their attitudes and beliefs towards immunosuppressant medication adherence
Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Kidney transplant patients
Orlistat Induced Modulation on the Fatty Acid Composition in Obese Females
Condition: Overweight
MeSH terms: Overweight
Study type: Interventional

Summary: 
      Orlistat is a popular drug approved for long-term use which produces weight loss by
      inhibiting triglycerides, main components of fats in the diet and reducing dietary fat
      absorption by up to 30%. The effect of this drug on human blood fatty acid profile has not
      been described yet. The FA composition of RBCs, plasma and platelets can be used to monitor
      of many pathological processes. This study presents alteration of FA composition in RBCM and
      phospholipids, triglycerides and cholesteryl esters from plasma of health obese female
      volunteers treated with nutritional orientation and orlistat (120 mg t.i.d) for 3 months.
    

Detailed description: 
      Obesity treatment requires lifestyle changes such as diet, exercise, and behavioral therapy.
      Orlistat is a popular drug approved for long-term use which produces weight loss by
      inhibiting triglycerides, main components of fats in the diet, from binding to the lipase
      enzyme active sites thus halting their subsequent breakdown into monoglycerides and free
      fatty acids necessary for fat digestion, reducing dietary fat absorption by up to 30%. The
      effect of this drug on human blood fatty acid profile has not been described yet.

      The FA profile is typical of each lipid and tissue, however, alterations in diets,
      pathological processes, drugs intervention, cigarettes and alcohol consumption can alter the
      FA profile. The FA composition of RBCs, plasma and platelets can be used to monitor these
      processes. This study presents alteration of FA composition in RBCM and phospholipids,
      triglycerides and cholesteryl esters from plasma of health obese female volunteers treated
      with nutritional orientation and orlistat (120 mg t.i.d) for 3 months.
    

Intervention name(s): Orlistat
Intervention type(s): Drug
Intervention description(s): Obese women were treated with orlistat 120mg 3 times a day for 4 months, compared with basal data and with normal weight women that didn´t receive orlistat
Intervention MeSH terms: Orlistat
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Fatty acids; orlistat; lipase; BMC (Body Mass Index) between 30 to 40 kg/m2; Women; 18 to 45 years; Premenopausal stage
Effects of Gemigliptin Versus Sitagliptin or Glimepiride With Metformin on Glucose Variability(MAGE, Glucose SD) Patients With Type 2 DM(STABLE Study)
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 4

Summary: 
      To compare efficacy and safety of initial combination therapy of Gemigliptin versus
      Sitagliptin or Glimepiride with Metformin on Glucose Variability(MAGE, Glucose SD) in
      Patients With Type 2 Diabetes Mellitus.
    


Intervention name(s): Gemigliptin + Metformin / Sitagliptin + Metformin / Glimepiride + Metformin
Intervention type(s): Drug
Intervention MeSH terms: Metformin; Sitagliptin Phosphate; Glimepiride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: diabetes mellitus
Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter
Condition: Multinodular Goiter
MeSH terms: Goiter
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine the safety and effectiveness of 2 different doses
      of modified-release recombinant human thyroid stimulating hormone (MRrhTSH) when administered
      with radioiodine in patients with multinodular goiter, a condition that involves the
      enlargement of the thyroid gland. We will also evaluate the safety and effectiveness of
      radioiodine therapy alone in these patients. The goal of the treatment is to determine if
      there was a reduction in the size of the goiter and to study if goiter symptoms have improved
      after 6 months and after 36 months.
    


Intervention name(s): Placebo; MRrhTSH; MRrhTSH
Intervention type(s): Other; Drug; Drug
Intervention description(s): 33 patients to placebo + 131-I arm; 33 patients to 0.01 mg MRrhTSH + 131-I arm; 33 patients to 0.03 mg MRrhTSH + 131-I arm
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
The Effects of Transcranial Direct Current Stimulation in Mild Cognitive Impairment
Condition: Mild Cognitive Impairment
MeSH terms: Cognitive Dysfunction
Study type: Interventional

Summary: 
      Objectives: 1) To examine whether the real transcranial direct current stimulation (tDCS)
      group would perform better in the cognitive training (CT) intervention than the sham tDCS
      group and the CT group; 2) To determine if, as a consequence of the stimulation generated by
      the use of tDCS, there would be a transfer effect to other cognitive domains and to cognitive
      tasks in activities of daily living; 3) To investigate the time and spatial responses of tDCS
      on the brain cortex during and after tDCS application.

      Hypothesis to be tested: By applying anodal tDCS with the combination of a CT delivered via
      the use of tablet PCs in older adults at risk of MCI, it will enhance their cognitive task
      performance in CT and subsequently generalize to other cognitive domains as well, involving a
      transferability to cognitive tasks in activities of daily living.

      Design and subjects: A multi-centered single-blinded randomized controlled trial (RCT) with
      three groups (CT alone/Sham tDCS with the combination of a CT/ Real tDCS coupling with CT)
      The participants who will take part of this study will be older adults at risk of MCI Study
      instruments: tDCS, Ipad, Neuron Up CT Apps, EEG. Interventions: The intervention will last
      for 9 sessions (3 sessions per week for 3 weeks). Sham tDCS and real tDCS, will be combined
      with the same CT which is used in the CT group. During the experimental intervention, anodal
      tDCS will be placed on left dorsolateral prefrontal cortex (DLPFC) and cathodal tDCS on the
      contralateral deltoid muscle with the combination of a CT. During the experimental
      intervention, anodal tDCS will be placed on left dorsolateral prefrontal cortex (DLPFC) and
      cathodal tDCS on the contralateral deltoid muscle with the combination of a CT.

      Main outcome measures: Cognitive assessments, CT performance, EEG. In addition, delta and
      theta frequency suppression and alpha increment power under the anode electrode will be
      observed.
    


Intervention name(s): tDCS
Intervention type(s): Device
Intervention description(s): Transcranial direct current stimulation
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Mild Cognitive Impairment; Neuromodulation
Mitral Valve in Hypertrophic Cardiomyopathy
Condition: Hypertrophic Obstructive Cardiomyopathy
MeSH terms: Cardiomyopathies; Cardiomyopathy, Hypertrophic; Hypertrophy
Study type: Interventional

Summary: 
      The purpose of the study is to assess the role of mitral valve apparatus in the development
      of outflow tract obstruction in patients with hypertrophic cardiomyopathy and to identify the
      best surgical treatment modality to relieve outflow tract obstruction in such patients
    

Detailed description: 
      It is well-known that mitral valve plays an important role in the development of left
      ventricular outflow tract obstruction in patients with hypertrophic cardiomyopathy. In order
      to further investigate this phenomenon, the following study aims to compare mitral valve
      geometry indices, as assessed by transthoracic echocardiography, two- and three-dimentional
      transesophageal echocardiography and mitral valve quantification analysis, and papillary
      musles' function, as assessed by 2D speckle tracking imaging, in patients with hypertrophic
      obstructive cardiomyopathy, patients with arterial hypertension and left ventricular
      hypertrophy and people without structural heart disease. This will provide information on the
      geometric characteristics of mitral valve that predispose to the development of obstruction.
      Futhermore, patients with hypertrophic obstructive cardiomyopathy that are eligible for the
      surgical relief of obstruction will be randomised into four groups according to the modality
      of intervention. These groups are as follows: 1) isolated extended septal myectomy; 2)
      extended septal myectomy + edge to edge mitral valve repair; 3) extended septal myectomy +
      posterior lealfet sliding plasty; 4) extended septal myectomy + secondary chordae
      transection. After surgery, said indices will be reassessed and the degree of outflow tract
      obstruction relief noted, in order to elicit which geometrical changes are produced by each
      type of intervention. Patients will be followed long-term, up to 5 years, in order to define
      whether the addition of the intervention on mitral valve helps abolish the residual gradient
      more effectively, and whether it translates into any survival benefit.
    

Intervention name(s): isolated septal myectomy; septal myectomy + edge-to-edge mitral valve repair; septal myectomy + posterior leaflet sliding plasty; septal myectomy + secondary chordae transection
Intervention type(s): Procedure; Procedure; Procedure; Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: hypertrophic cardiomyopathy, mitral valve, echocardiography
WOODCAST Hand Resting Splint - Study of User Experience
Condition: Patient Satisfaction
Study type: Observational

Summary: 
      The aim of the study is to collect comments form users of new type of hand resting splint.
    

Detailed description: 
      An ecologically friendly and biodegradable wood-plastic composite cast (WOODCAST) is used as
      a hand resting splint in this study.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients whos treatment involves a hand resting splint. Finnish language skills (written
        and spoken).