bioihbjkbjnl/mcl2 huggingface dataset:
Different Types of Electrostimulation Probes During IONM
Condition: Thyroid Diseases
MeSH terms: Thyroid Diseases
Study type: Observational

Summary: 
      Intraoperative nerve monitoring is often used in many centers during thyroidectomy. According
      to the investigators' knowledge, there's no study showing superiority between bipolar and
      monopolar stimulation probes used for nerve monitoring during thyroid surgery. In this study,
      the investigators aimed to compare two different types of probes and find out
      superiorities.Twenty-one patients who underwent primary total thyroidectomy or
      hemithyroidectomy were included in the study. During surgery, amplitude and latency values
      obtained in the same patient with both bipolar and monopolar stimulation probes from 10
      different anatomical spots [vagal nerve, recurrent laryngeal nerve inferior portion,
      recurrent laryngeal nerve superior portion, external branch of superior laryngeal nerve
      (EBSLN)] were recorded prospectively, both when sheath was intact and after being dissected.
    


Intervention name(s): Bipolar and monopolar probes (SPESS MEDICA S.r.l. Via Buccari 16153 Genova (GE), Italy) administered to all participants.
Intervention type(s): Device
Intervention description(s): Bipolar and monopolar probes (SPESS MEDICA S.r.l. Via Buccari 16153 Genova (GE), Italy) administered to all participants.They compared each others(bipolar vs monopolar) via amplitudes and latency values.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Consequtive patients who underwent thyroid surgery
      
Keywords: IONM; thyroidectomy; bipolar probe; monopolar probe
Toujeo Versus NPH Self-titration Study
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 4

Summary: 
      This is a 24 week, multicentre, prospective, randomized, controlled, parallel-designed (1:1)
      pilot study.The study will compare glycemic variability in patients treated with insulin
      glargine U300/ml insulin versus conventional (NPH) insulin using a self titration
      algorithm.50 type 2 diabetes patients who are newly started on insulin will be recruited.
      They will be randomly allocated to either insulin glargine U300 or NPH insulin for 26 weeks.
      All subjects will follow a insulin-self titration algorithm. The study will consist of 9
      visits over 26 weeks. Blood glucose variability will be collected by CGM for 7 consecutive
      days at baseline (week -1) and at week 24.Secondary endpoints other than data on glycemic
      variability, including HbA1c, fasting plasma glucose, inflammatory markers will be measured
      during three periods (week 0, week 12 and week 24).
    


Intervention name(s): Insulin Glargine 300 UNT/ML; Neutral protamine hagedorn insulin
Intervention type(s): Drug; Drug
Intervention description(s): Self titration of insulin glargine U300; Self titration of NPH insulin
Intervention MeSH terms: Insulin; Insulin, Globin Zinc; Insulin Glargine; Insulin, Isophane; Isophane Insulin, Human; Isophane insulin, beef; Protamines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Pharmacokinetic Study Comparing Salmeterol/Fluticasone Easyhaler Products and Seretide Diskus
Condition: Asthma
Study type: Interventional
Phase: Phase 1

Summary: 
      The purposes of this study is to compare the test products Salmeterol/fluticasone Easyhaler
      with marketed product Seretide Diskus in terms of the drug absorbed into the blood stream
    


Intervention name(s): Salmeterol/fluticasone Easyhaler; Salmeterol/fluticasone Easyhaler with charcoal; Seretide Diskus; Seretide Diskus with charcoal
Intervention type(s): Drug; Drug; Drug; Drug
Intervention MeSH terms: Fluticasone; Xhance; Salmeterol Xinafoate; Fluticasone-Salmeterol Drug Combination; Charcoal
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Serum Opiorphin Level After Intraoperative Intravenous Lidocaine Infusion
Condition: Cancer, Breast
MeSH terms: Breast Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      A prospective, double blinded and randomized study included women with breast cancer and
      underwent mastectomy, and randomly allocated into two groups of equal size. Lidocaine group
      and control group.
    

Detailed description: 
      Women aged between 18 and 60 years old with breast cancer and underwent mastectomy, ASA I or
      II were included in the study.

        -  Group I (lidocaine): Patients were received intravenous 1 mg/kg of 2 % lidocaine as a
           loading dose (just before induction of anesthesia) then received 2mg/kg /h lidocaine as
           maintenance dose (with maximum of 200 mg/h) till the end of the operation (skin
           closure).

        -  Group II (control):- A standardized equal volume of intravenous bolus dose of normal
           saline was given as loading dose then normal saline was administered on an equal rate of
           infusion.
    

Intervention name(s): Lidocaine; Normal saline
Intervention type(s): Drug; Drug
Intervention description(s): ): Patients were received intravenous 1 mg/kg of 2 % lidocaine as a loading dose (just before induction of anesthesia) then received 2mg/kg /h lidocaine as maintenance dose (with maximum of 200 mg/h) till the end of the operation (skin closure).; A standardized equal volume of intravenous bolus dose of normal saline was given as loading dose then normal saline was administered on an equal rate of infusion.
Other intervention name(s): Active group; Placebo group
Intervention MeSH terms: Lidocaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
A Study to Investigate the Absorption, Metabolism, and Excretion of JNJ-38518168 After a Single Oral Dose in Healthy Male Participants.
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of the study is to investigate the absorption, metabolism, and excretion of 14C
      JNJ-38518168 in healthy adult male participants after a single oral dose of 30 mg 14C
      JNJ-38518168.
    

Detailed description: 
      This is an open-label (all people know the identity of the intervention), single-center,
      single-arm (single group), and single-dose study. This study will include a screening period
      of 21 days prior to study medication administration. Six men will be enrolled and admitted to
      the clinical study unit on the morning of Day -1. On Day 1, participants will receive a
      single oral solution dose containing 30 mg of 14C JNJ-38518168 given as an oral solution. The
      participants will be confined to the clinical study unit for at least 360 hours after dosing
      ie, Day -1 through Day 14 and they will be discharged on Day 15; however, participants who,
      by Day 15, do not meet the discharge criteria will extend their residency in the study unit
      for up to Day 21. They will return to the study center 7 to 10 days after discharge for the
      final safety follow-up. The study will include the following safety evaluations: adverse
      event, vital sign, 12-lead electrocardiography, physical examination, and clinical laboratory
      test. For each participant the total duration in the study is approximately 6 weeks
      (including screening and safety follow-up) or 7 weeks for participants who extend the
      residence up to Day 21.
    

Intervention name(s): JNJ-38518168
Intervention type(s): Drug
Intervention description(s): Following an at least 10-hour overnight fast, participants will receive a single dose containing 30 mg of 14C JNJ-38518168 given as an oral solution on Day 1
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Healthy; JNJ-38518168; 14C-JNJ-38518168; Absorption; Metabolism; Excretion
Pepsin in Patients With Functional Dyspepsia
Condition: Functional Gastrointestinal Disorders; Abdominal Pain; Dyspepsia; Nausea; Vomiting; Flatulence
MeSH terms: Gastrointestinal Diseases; Digestive System Diseases; Vomiting; Dyspepsia; Abdominal Pain; Flatulence
Study type: Observational

Summary: 
      This non-interventional, observational study investigates the course of symptoms in patients
      with functional dyspepsia under treatment with a fixed combination of pepsin and amino acid
      hydrochloride over a period of approximately 6 weeks. The change of the Gastrointestinal
      Symptom Score (GIS©) was the primary parameter for the assessment of efficacy and was
      performed at baseline, after 3 and 6 weeks of treatment respectively. Safety measures
      included recording of AEs and physical examination as well as measurement of vital signs. The
      aim was to observe 100 patients during the course of this non-interventional study.
    


Intervention name(s): Pepsin
Intervention type(s): Drug
Other intervention name(s): amino acid hydrochloride
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients presented with acute and chronic gastrointestinal symptoms, it was decided on the
        basis of their history, previous findings (diagnostic endoscopy and imaging, if available)
        and findings on physical examination whether they could participate in the postmarketing
        surveillance.
      
Keywords: Dyspepsia; Observational trial; Enzyme therapy; Pepsin
Dexmedetomidine in Erector Spinae Block in Postoperative Analgesia
Condition: Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      60 female patients scheduled for breast cancer surgeries, allocated in 3 groups for erector
      spinae block with bupivacaine and erector spinae block with dexmedetomidine added to
      bupivacaine and control group. During anesthesia: total intraoperative fentanyl required will
      be recorded. After surgery the first time of request for analgesic will be recorded. after
      request of analgesia all patients will be connected to PCA device containing morphine
      solution, the amount of morphine consumed during the first 24 hours will be recorded.
    

Detailed description: 
      60 female patients scheduled for breast cancer surgeries, allocated in 3 groups for erector
      spinae block with bupivacaine and erector spinae block with dexmedetomidine added to
      bupivacaine and control group. During anesthesia: total intraoperative fentanyl required will
      be recorded. After surgery the first time of request for analgesic will be recorded. after
      request of analgesia all patients will be connected to PCA device containing morphine
      solution, the amount of morphine consumed during the first 24 hours will be recorded. Other
      secondary outcomes are numerical rating scales and incidence of opioid side effects.
    

Intervention name(s): erector spinae block with bupivacaine; erector spinae block with bupivacaine + dexmedetomidine
Intervention type(s): Procedure; Procedure
Intervention description(s): Patients will receive a sonar-guided erector spinae plane block with 20 ml of bupivacaine 0.5%; Patients will receive a sonar-guided erector spinae plane block with 19 ml of bupivacaine 0.5%+ 1 ml dexmedetomidine
Intervention MeSH terms: Dexmedetomidine; Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Erector spinae block.; dexmedetomidine.; Postoperative analgesia
On the Impact of Common Sweetening Agents on Glucose Regulation, Cognitive Functioning and Gut Microbiota
Condition: Healthy Subjects
Study type: Interventional

Summary: 
      The study intention is to investigate, in healthy humans, effects of 3 commonly used
      sweeteners on cardiometabolic risk markers, cognitive functions, and influences on gut
      microbiota composition.
    

Detailed description: 
      Healthy subjects will be included in a crossover study with the purpose to investigate
      effects of 3 commonly used sweeteners on cardiometabolic risk markers, cognitive functions,
      and influences on gut microbiota composition. The subjects will consume each test product for
      14 days in a random order, separated by at least a two-week washout period. On the last day
      in each intervention period, i.e. at day fifteen, the last test portion will be consumed
      together with a standardized evening meal at 9.00 pm. Thereafter the subjects are fasting
      until arriving to the experimental unit. Upon arrival, test variables in blood will be
      determined at fasting and repeatedly for 3h postprandial a standardised breakfast served
      approximately at 8.00 am. Cognitive performance will be determined in the postprandial period
      with tests evaluating working memory capacity, selective attention, psychomotor reaction
      time, and executive functions. After each intervention period, faecal samples will be
      collected for characterization of gut microflora.
    

Intervention name(s): Sucrose; Stevia glycosides; saccharin
Intervention type(s): Other; Other; Other
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Keywords: no specific condition
Investigation of Pectoralis Muscle Strength in Elderly With Interstitial Lung Disease
Condition: Interstitial Lung Disease; Idiopathic Pulmonary Fibrosis; Sarcoidosis, Pulmonary; Geriatric
MeSH terms: Lung Diseases; Pulmonary Fibrosis; Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Sarcoidosis, Pulmonary; Sarcoidosis
Study type: Observational

Summary: 
      Interstitial lung disease (ILD) is a restrictive lung disease characterized by impaired lung
      function, exercise limitation and skeletal muscle dysfunction. There is limited data on
      skeletal muscle function in ILD, most of which are focused on the lower limb muscles. The aim
      of this study were to evaluated the change of pectoralis muscle strength and relationship of
      pulmonary function with pectoralis muscle strength.
    

Detailed description: 
      This study consisted of intervention and control groups. Thirty one patients with ILD were
      included in the patient's group and 37 healthy volunteers in the control group. All
      participants were selected from the geriatric population. Demographic and cardiopulmonary
      physiotherapy assessment of all participants were performed. Lung function test, maximal
      inspiratory and expiratory pressure and pectoralis muscle strength were measured in
      participants of both groups. All measurements were performed once.
    

Intervention name(s): Assessment of pulmonary function and pectoralis muscle strength
Intervention type(s): Other
Intervention description(s): In both groups, forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and FEV1 / FVC ratio were measured with portable spirometer according to the guidelines of the American Thoracic Society (ATS) and the European Respiratory Society (ERS). Maximal inspiratory (MIP) and expiratory pressure (MEP) were evaluated with mouth pressure device as per ATS/ERS guidelines. Sensation of dyspnea was assessed with Modified medical council research scale. Pectoralis muscle strength were measured isometrically using with digital hand held dynamometer.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The patient's group was selected from among the patients who applied to Süreyyapaşa Chest
        Diseases and Thoracic Surgery Training and Research Hospital.

        The control group was selected among volunteers invited from the local community.
      
Keywords: pectoralis muscle strength; lung function test; respiratory muscle strength; horizontal adduction
Preventive Intramuscular Phenylephrine in Elective Cesarean Section Under Spinal Anesthesia
Condition: Elective Cesarean Section; Spinal Anesthesia
Study type: Interventional

Summary: 
      Spinal anesthesia is the preferred anesthesia method in cesarean section to provide
      satisfactory analgesia and muscle relaxant with less impact on respiratory system. However,
      hypotension often occurred due to the block of sympathetic nerve, causing maternal decline of
      frontal lobe oxygenation, nausea vomit and the decrease of uteroplacental perfusion. Several
      measures are used to prevent or treat hypotension caused by spinal anesthesia: prehydration,
      limb compression, left lateral tilt of operation tables or usage of vasopressors. In the past
      decade, the most recommended vasopressor to prevent or treat hypotension in spinal anesthesia
      in cesarean section was phenylephrine, an α-adrenergic receptor, maintaining maternal blood
      pressure and fetal acid-base state. In clinical work, there are two ways to use phenylephrine
      : intravenous method with less onset time (several seconds and duration (several minutes) and
      intramuscular method with longer onset time (10-15 minutes) and duration (1 hour). Many
      trials demonstrated the protective effect of preventive intravenous phenylephrine on maternal
      hemodynamics and neonatal acid-base status. However, few trials reported the effect of
      preventive intramuscular phenylephrine on cesarean section under spinal anesthesia.
    

Detailed description: 
      Hypotension often occurred in parturients undergoing cesarean section in spinal anesthesia.
      This study aims to determine whether preventive intramuscular phenylephrine can better the
      fetal acid-base state and maternal hemodynamics.
    

Intervention name(s): Phenylephrine; Normal saline; Bupivacaine
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 5 mg (1ml) phenylephrine intramuscular injection will be given into the gluteus maximus muscle before anesthesia.100ug (1ml) phenylephrine intravenous injection will be given after the subarachnoid injection is completed .; 1ml 0.9% normal saline intramuscular injection will be given into the gluteus maximus muscle before anesthesia and after the subarachnoid injection is completed.; All patients will receive spinal anesthesia with bupivacaine.
Other intervention name(s): Metasympatol; Physiological saline; Marcaine
Intervention MeSH terms: Phenylephrine; Oxymetazoline; Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Intramuscular; Phenylephrine
A Study to Evaluate the Safety and Efficacy of HAE1 in Subjects With Moderate to Severe Allergic Asthma
Condition: Allergic Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a Phase II, multicenter, randomized, double blind, placebo controlled, multiple-dose
      study designed to evaluate the efficacy, safety, and tolerability of subcutaneously
      administered HAE1 in subjects 12-75 years old with moderate to severe asthma whose symptoms
      are inadequately controlled with moderate to high-dose ICS and LABA.
    


Intervention name(s): HAE1 (PRO98498)
Intervention type(s): Drug
Primary purpose: Treatment
Bowen's Technique in Patients With Adhesive Capsulitis
Condition: Adhesive Capsulitis
MeSH terms: Bursitis
Study type: Interventional

Summary: 
      This study will help the physiotherapists in overcoming the challenges and barriers in the
      treatment. It will also help researchers in acquiring sufficient knowledge for further
      research on the Bowen technique and its various applications as this technique is not widely
      applied in the field of physical therapy treatment.
    

Detailed description: 
      The application of the Bowen technique, producing significant results, will be opted in
      treatment for the better, improved, and innovative noninvasive management of Adhesive
      Capsulitis. This study will help the physiotherapists in overcoming the challenges and
      barriers in the treatment. It will also help researchers in acquiring sufficient knowledge
      for further research on the Bowen technique and its various applications as this technique is
      not widely applied in the field of physical therapy treatment.
    

Intervention name(s): Bowen's technique; Conventional physical therapy
Intervention type(s): Other; Other
Intervention description(s): Initially, cup move is performed which requires a vertically rolling Bowen move over the posterior border of the deltoid muscle above the axillary crease.
The subject's arm is held flexed at 90 degrees at mid-chest height. Then, the elbow is slowly and passively moved in the direction of the opposite shoulder.
After maximal adduction of the arm, the therapist firmly taps the lateral aspect of the shoulder with the heel of his/her hand.
The arm is then carried back to the original start position, where the therapist gently moves superiorly and slightly laterally over the anterior fibers of the deltoid. The arm is then carefully lowered.
The therapist strives to undertake a minimum of moves and procedures to trigger the body's own self-healing powers and assess how much pressure to use and where and when to perform a move to release the build-up of stress.
40-minute sessions thrice a week for 6 weeks.; Hot pack and transcutaneous electrical nerve stimulator (TENS) for 15 minutes.
Pendulum stretch, 10 revolutions.
Cross body stretch, 4 repetitions.
Towel stretch/hand behind the back, 4 repetitions.
Isometric internal and external rotation exercises. 40-minute sessions thrice a week for 6 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Adhesive capsulitis; Shoulder; Pain; Bowen technique