bioihbjkbjnl/mcl2 huggingface dataset:
Study of Oral Papillomavirus In Teens and Twenties
Condition: STD
Study type: Observational

Summary: 
      Recently human papillomavirus (HPV) has been recognized to cause some oropharyngeal (tonsil)
      cancer. But very little is known about oral HPV infection and risk factors. This study will
      evaluate how common oral HPV infection is, what sexual behaviors are associated with risk for
      infection, and how long infections tend to last.
    

Detailed description: 
      18-25 year old individuals are being recruited from STD clinics in Baltimore County and
      followed every three months for this study.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        High risk young adults
      
Keywords: HPV; oral cancer; young adults
Establishment and Evaluation to the Effects of a Clinical Pathway for Acute Ischemic Stroke
Condition: Acute Ischemic Stroke
MeSH terms: Stroke; Ischemic Stroke; Cerebral Infarction; Ischemia
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to determine whether the clinical pathway for acute ischemic
      stroke(with combination of traditional Chinese medicine and western medicine) is able to
      improve the outcome of acute ischemic stroke and evaluate its effect on hospital day and
      cost, etc. Meanwhile, the study will discuss the safety and efficiency of this kind of
      Clinical Pathway
    

Detailed description: 
      Eligibility Ages Eligible for Study: 18 Years to 85 Years Genders Eligible for Study: Both
      Accepts Healthy Volunteers: No

      Criteria

      Inclusion Criteria:

      Those clinically diagnosed with acute ischemic stroke ； 18-85 years old； Over 6 hours and
      within 14 days from onset 4<=NIHSS <=22; Informed consent signed by patient or his/her family
      ；

      Exclusion Criteria:

      Hemorrhagic stroke; Cerebral hernia; Serious heart, liver, lung, kidney functional
      failure，malignancy; Not cooperative with physician; Psychological disorder; Already taken
      part in other clinical drug trial within the past 3 months
    

Intervention name(s): aspirin，chinese herbs；
Intervention type(s): Drug
Intervention description(s): aspirin 300mg/100mg,qd,chinese herbs, one dose ，qd
Other intervention name(s): Bayer
Intervention MeSH terms: Aspirin
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Acute Ischemic Stroke；clinical pathway;TCM；
A Study of the Experience of Music Therapy in Cancer Patients With Delirium
Condition: Cancer Patients With Delirium
MeSH terms: Delirium
Study type: Observational

Summary: 
      The purpose of this study is to improve our understanding of the experience of music therapy
      by cancer patients with delirium, and the experience of music therapists working with these
      patients. The researchers are focusing on patients with delirium because of the challenging
      symptoms of this condition.

      At MSK, music therapy is routinely used in patients with cancer. Music therapy sessions are
      done at the patient's bedside, where the music therapist plays live music on a guitar,
      keyboard, harp, or percussion instrument, sometimes as accompaniment to singing.
    


Intervention name(s): Music therapy; Interviews
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Music therapy sessions may last 20-60 minutes, with length and frequency to be determined mutually (generally 1-3 times per week). Music therapy sessions are done at the patient's bedside, where the music therapist plays live music on a guitar, keyboard, harp, or percussion instrument, sometimes as accompaniment to singing.; Each interview will be conducted in person in a private setting (with the exception of caregivers, who have the option to conduct interviews over the phone if it is not feasible to take place in the hospital). Each interview will follow a semi-structured interview guide and will ask for consent to audio record the interviews .
Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patient subjects who are referred for music therapy will be identified to the researcher by
        a board-certified music therapist on staff at MSKCC (excluding the Principal Investigator).
      
Keywords: Music therapy; 19-270
Effect of Flexibility Training Versus Static Stretching on Hamstring Muscle Length and Patterns of Lumbar Flexion
Condition: Static Stretching; Dynamic Stretching; Muscle; Low Back
Study type: Interventional

Summary: 
      Mobility training in the form of stretching and flexibility training of our skeletal muscle
      is a common exercise. However, the evidence are scare and there are only a few studies
      comparing the effect of prolonged static stretching (> 90 sec) and dynamic flexibility
      training as to which of these methods has the best length-enhancing effect over time.
      Further, in clinical practice concerning low back pain, the possibility of a thigh hamstrings
      muscles to affect movement control of the spine is often mentioned, a link not fully explored
      in a controlled condition. The purpose of this study is to compare the effect of eight weeks
      of dynamic flexibility training versus prolonged static stretching on mobility in the
      hamstring muscles in adults with reduced mobility in the muscles at the back of the thigh.
      The aim is also to compare the sustained effect of flexibility training between the two
      groups, eight weeks after completion of the intervention. Furthermore, the aim is to explore
      how different forms of flexibility training affects movement patterns of the lumbar spine in
      adult persons with reduced mobility in the hamstrings.
    


Intervention name(s): Mobility of the hamstrings muscles
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Acceptability/Feasibility of HIV Testing by ELISA or Rapid Test to Adult Patients in Paris, France
Condition: HIV
Study type: Interventional

Summary: 
      CDC recommends universal HIV testing in all adults, at least once during life, to reduce the
      pool of infected patients unaware of their status. Routine universal HIV testing can use
      "classical" ELISA tests from serum, or rapid tests, ideally from finger-stick whole blood
      (FSB), which have shown close predictive values from classical tests. The investigators will
      compare the acceptability and feasibility of the two methods.
    

Detailed description: 
      The multi-center prospective randomized study will compare the acceptability and feasibility
      of routine universal HIV testing to adult patients consulting their general practitioner in
      Paris, France, using either the " classical " ELISA tests from serum or rapid tests from FSB
      (Insti®).
    

Intervention name(s): HIV testing by ELISA; HIV testing by rapid test
Intervention type(s): Procedure; Procedure
Intervention description(s): HIV testing randomized between ELISA or rapid test; HIV testing randomized between ELISA or rapid test
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Adult outpatients; Paris, France
The Effect of Pioglitazone and Rosiglitazone on Atherosclerotic and Inflammatory Markers in Patients With Metabolic Syndrome
Condition: Metabolic Syndrome
MeSH terms: Metabolic Syndrome; Syndrome
Study type: Interventional
Phase: Phase 4

Summary: 
      Pioglitazone and rosiglitazone are used in the treatment of diabetic patients.
      Thiazolidinediones increase insulin sensitivity and show favorable effect blood glucose
      levels and lipid profiles. The effect of these two different thiazolidinediones on
      atherosclerotic and inflammatory markers has not been compared in prospective manner. The
      purpose of this prospective, randomized, open-label, crossover trial is to compare the effect
      of pioglitazone and rosiglitazone on atherosclerotic and inflammatory markers in patients
      with metabolic syndrome.
    


Intervention name(s): Pioglitazone, Rosiglitazone
Intervention type(s): Drug
Intervention MeSH terms: Pioglitazone; Rosiglitazone
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Rosiglitazone; Pioglitazone; FMD; PWV; atherosclerosis
A Single-Center Pilot Study to Assess Macular Function
Condition: Macular Degeneration
MeSH terms: Macular Degeneration
Study type: Observational

Summary: 
      This study seeks to evaluate a novel endpoint for future dry AMD clinical trials.
    


Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Three groups of subjects will be enrolled:

          1. Normal healthy subjects aged 20-29 years

          2. Normal healthy subjects aged 60-90 years

          3. Subjects with early dry AMD
      
Keywords: Non-exudative age-related macular degeneration
Impact of COVID-19 Pandemic on Perceived Exercise Benefits and Barriers
Condition: COVID; Isolation, Social
MeSH terms: COVID-19
Study type: Observational

Summary: 
      It is aimed to determine the physical activity level and exercise benefits and barriers
      caused by Covid-19 pandemic and reveal the relationship between them.
    

Detailed description: 
      Study hypothesis that people are tend to be physically inactive while Covid-19 pandemic. It
      is aimed to determine the exercise benefits and barriers caused by Covid-19 pandemic and
      reveal the relationship among gender, age, marial status and physical activity level.
    

Intervention name(s): Online Survey
Intervention type(s): Other
Intervention description(s): Volunteer individuals enrolled the study after approval an online informed consent form. Sociodemographic data of the participants recorded as an online survey. Then, patient reported outcomes were used to assess physical activity level (International Physical Actvity Questionairre) and Exercise Benefits and Barriers (Exercise Benefits and Barriers Scale).
Observational model: Ecologic or Community
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        The population of the individuals between 15 - 65 ages in Turkey is 56.391.925 people. It
        is calculated that there are 42.463.119 individuals cover the criterion as universe of the
        study.
      
Keywords: Covid 19; Physical activity level; Exercise benefits and barriers; Turkish Society; Social Isolation
The Effect of Gastric Bypass Surgery on Diabetes
Condition: Type II Diabetes
MeSH terms: Diabetes Mellitus, Type 2
Study type: Observational

Summary: 
      This study will investigate the effects of gastric bypass surgery on type II diabetes. The
      study will recruit patients with type II diabetes having Roux-en-Y gastric bypass, patients
      without type II diabetes having Roux-en-Y gastric bypass, and control subjects (patients
      having gastroscopy, but no surgery). Targeted enrollment is 30 patients per group. Samples of
      intestine are taken prior to surgery in gastroscopy, during surgery, and 6 months after
      surgery during gastroscopy. Meal test with incretin measurements, and feces and blood
      samplings are performed before and after surgery

      Hypotheses are:

        -  The pathogenesis of type II diabetes is linked to changes in the expression of
           intestinal endocrine cells

        -  The changes in the incretine excretion after the gastric bypass surgery partly explain
           the amelioration of type II diabetes

        -  The oxidation of lipoprotein is diminished after the gastric bypass surgery slowing the
           development of atherosclerosis

        -  The immunologic functions of the intestine are changed by the gastric bypass surgery
           attenuating systemic inflammation

        -  The gastric bypass surgery changes cholesterol and bile acid metabolism

        -  The gastric bypass surgery changes the fecal microbiota

      Primary end points are:

        -  Changes in the amounts of endocrine cells in ventricle, duodenum and jejunum

        -  Changes in the incretine secretion studied with liquid meal test

        -  Changes in the oxidation of lipoproteins

        -  Changes in the immunologic markers in ventricle, duodenum and jejunum

        -  Changes in the amounts of phytosterols, cholesterol metabolites and bile acids

        -  Changes in fecal microbiota
    


Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        All patients are recruited from Oulu University Hospital
      
Biospecimen description: 
      Serum, plasma, feces, intestinal tissue
Study to Assess the Absorption, Metabolism, Excretion and Pharmacokinetics of [14C]-AKB-9778
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      Open-label, single-dose, Phase 1 study to assess the absorption, metabolism, excretion and
      pharmacokinetics of [14C]-AKB-9778 in healthy male volunteers
    


Intervention name(s): AKB-9778 subcutaneous injection
Intervention type(s): Drug
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Body Composition, Glucose Metabolism, Insulin Resistance and Gene Expression in Muscle Cells in Healthy Overweight Women
Condition: Obesity; Type 2 Diabetes; Polycystic Ovary Syndrome
MeSH terms: Polycystic Ovary Syndrome; Overweight; Insulin Resistance
Study type: Observational

Summary: 
      In this study, we will clarify the degree of insulin resistance and characterise muscle
      glucose metabolism and gene expression in a group of overweight healthy women. The study will
      clarify how overweight influences body glucose metabolism and thereby in the long-run
      increases the risk for developing type 2 diabetes. Moreover, the study may clarify why some
      overweight women develop hormone disorders and diabetes while others remain healthy.

      The study is essential as many patients suffer from diseases aggravated by overweight. In
      addition, a genetic disposition for diabetes or polycystic ovary syndrome may give rise to
      the disease if the patient gains weight. It is therefore important that weight-matched
      control subjects are included in projects with overweight patients.

      This clinical trial includes 10 overweight women with regular hormones and normal level of
      male sex hormone. The patients included must be healthy, take no medications influencing the
      study results. The subjects must take no contraceptive pills or receive any other hormone
      treatment.

      In connection with the investigation, the following will be carried out on all patients:
      clinical examination, blood tests, hyperinsulinaemic euglycaemic clamp, muscle biopsies, bone
      scan.

      The purpose of the study is to gain more knowledge of how overweight influences women's risk
      of developing hormone diseases and diabetes.
    


Time perspective: Prospective
Keywords: Polycystic ovary syndrome; growth hormone; insulin resistance; overweight; glucose metabolism
Study To Evaluate The Efficacy And Safety Of Balovaptan In Adults With Post-Traumatic Stress Disorder (PTSD)
Condition: Stress Disorders, Post-Traumatic
MeSH terms: Stress Disorders, Traumatic; Stress Disorders, Post-Traumatic
Study type: Interventional
Phase: Phase 2

Summary: 
      This study will evaluate the efficacy and safety of 10 mg of oral administration balovaptan
      once a day (QD) compared with matching placebo in adults with PTSD.
    


Intervention name(s): Balovaptan; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Intervention of oral administration of 10mg balovaptan QD for 12 weeks followed by two weeks of follow-up period; Matching placebo
Intervention MeSH terms: Balovaptan
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Adaptation in Polyphenol Bioavailability and Bioactivity During Long Term Exposure to Polyphenol-Rich Foods
Condition: Healthy
Study type: Interventional

Summary: 
      There are two primary objectives to be addressed in this study: to assess the differential
      response in bioavailability and metabolic pathways between lean and obese individuals exposed
      to acute, short term (14 day), and long-term (10-week) consumption of polyphenol-rich fruits
      (berries and apple), and beverages (tea); and to determine the differential systemic and gut
      anti-inflammatory response between obese and lean individuals exposed to polyphenol-rich
      fruits (berries and apple), and beverages (tea).
    


Intervention name(s): Controlled diet
Intervention type(s): Other
Intervention description(s): Volunteers will be provided a controlled diet during the entirety of the 10 week treatment period. Meals will be prepared using traditional American foods.
The controlled diet will include polyphenol-rich foods, including apples, berries, and green tea. A blend of multiple polyphenol-rich foods was chosen to investigate whole foods, multiple commodities, and multiple bioactives.
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: pharmacokinetics; polyphenol metabolites; lean individuals; obese individuals
Comparative Evaluation of Post-endodontic Pain Using Two Rotary Instrumentation Systems
Condition: Pain
Study type: Interventional

Summary: 
      In this study the investigators aim to compare the post-operative pain using two single-file
      endodontic rotary systems : Reciproc and One shape.
    

Detailed description: 
      Comparison of the post operative pain with two rotary systems including Reciproc and One
      shape.

      Confounding factors were neutralized and the rotary systems were compared.
    

Intervention name(s): Control; Reciproc; One shape
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): K-file hand instrumentation; reciprocating rotary instrument; full rotation protocol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Root canal treatment; pain; endodontic instruments
Reactogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Rotarix™ (Human Rotavirus Vaccine) in Indian Infants
Condition: Infections, Rotavirus
MeSH terms: Rotavirus Infections
Study type: Observational

Summary: 
      This post marketing surveillance will evaluate reactogenicity and safety data of human
      rotavirus vaccine when administered to healthy infants according to the Prescribing
      Information in India.
    


Intervention name(s): Rotarix™
Intervention type(s): Biological
Intervention description(s): Two doses of oral vaccine.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        subjects from the age of 6 weeks at the time of the first Rotarix™ vaccination and less
        than 24 weeks of age at the time of second Rotarix™ vaccination
      
Keywords: Gastroenteritis
Needlescopic Versus Transvaginal/Transumbilical Cholecystectomy
Condition: Calculus of Gallbladder With or Without Cholecystitis; Laparoscopic Cholecystectomy
MeSH terms: Cholecystitis; Cholelithiasis; Cholecystolithiasis; Gallstones; Calculi
Study type: Interventional

Summary: 
      Laparoscopic surgery has become the golden standard for the removal of the gallbladder.
      Recently, developments have been made so that operations can be performed through a natural
      orifice instead of the abdominal wall, thus minimizing the trauma of a procedure. This study
      compares the transvaginal/transumbilical cholecystectomy with the laparoscopic operation
      using 2-3mm instruments in female patients. It also examines the benefits and disadvantages
      related to postoperative pain, cosmetic aspects, and potential physiological alterations to
      the transvaginal approach that affect sexual intercourse.
    

Detailed description: 
      The amount of trauma inflicted, especially in abdominal operations, depends largely on target
      organ access. Great efforts have been made to minimize access trauma. The further development
      of laparoscopy led to the miniaturization of surgical instruments and otherwise the use of
      natural orifices, like the stomach, rectum or vagina. The cholecystectomy is currently
      performed needlescopicly with 2-3 mm trocars and in transumbilically assisted transvaginal
      technique. The aim of this randomized study is to compare these two techniques in female
      patients that are in need of an elective cholecystectomy. The patients will be randomized on
      a 1:1 ratio into two treatment groups. In the needlescopic group the investigators will use
      two 2-3 mm working trocars and one 10 mm optic trocar, also to extract the gallbladder. In
      the transvaginal/transumbilical group the investigators will perform the Zornig technique
      using a 5 mm trocar in the umbilicus and a 10 mm trocar together with a 5 mm seizing forceps
      through the posterior vaginal vault. The primary endpoint of this trial is to measure the
      intensity of pain in motion measured from the day of the operation until postoperative day 2.
      Four different measurements of pain will be used. Furthermore the investigators examine
      perioperative complications as security parameters. The trial is supported in part by the
      German Ministry of Research and Education (CHIR-Net grant, BMBF No. 01-GH-0605).
    

Intervention name(s): Transvaginal/transumbilical; Needlescopic with 3 trocars
Intervention type(s): Procedure; Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Gallbladder; cholecystectomy; NOTES; natural orifice transluminal endoscopic surgery; gallstone