bioihbjkbjnl/mcl2 huggingface dataset:
Comparison of Flexor Retinaculum Stretch and Carpal Mobilizations in Patients With Carpal Tunnel Syndrome.
Condition: Carpal Tunnel Syndrome
MeSH terms: Carpal Tunnel Syndrome; Syndrome
Study type: Interventional

Summary: 
      Comparison of flexor retinaculum stretch and carpal mobilizations in carpal tunnel syndrome
      patients.
    

Detailed description: 
      -  Carpal Bones Mobilization tends to improve the symptoms of carpal tunnel syndrome.

        -  Manual stretching of the flexor retinaculum effective in CTS patients.

        -  As there are no studies available to compare the effectiveness of flexor retinaculum
           stretch and carpal bone mobilization for the treatment of CTS, hence the purpose of this
           study is to find the effectiveness of carpal bone mobilization and flexor retinaculum
           stretch in improving Pain, ROM and Functional Status in patient with CTS.
    

Intervention name(s): Carpal bone mobilization; Flexor retinaculum stretch; Carpal bone mobilization and flexor retinaculum stretch
Intervention type(s): Other; Other; Other
Intervention description(s): Carpal bone mobilization 5 repetition/1 set lasted for 15 secs followed by 10 secs of rest- 3 sessions on alternate days per week for 04 weeks.
Total of 12 sessions will be given, each consisting of 45 mins.; Flexor retinaculum stretch 5 repetitions/ 1 set held for 60 secs at a time,-3 sessions on alternate days per week for 04 weeks.
Total of 12 sessions will be given, each consisting of 45 mins.; Carpal bone mobilization 5 repetition/1 set lasted for 15 secs followed by 10 secs of rest.3 sessions on alternate days per week for 04 weeks.
Flexor retinaculum stretch 5 repetitions/ 1 set held for 60 secs at a time-3 sessions on alternate days per week for 04 weeks.
Total of 12 sessions will be given, each consisting of 45 mins.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: median neuropathy; thenar muscle atrophy; compression neuropathy; flexor retinaculum
Safety, Tolerability and Pharmacokinetic Study of MB12066 in Healthy Volunteers
Condition: Metabolic Syndrome; Obesity
MeSH terms: Metabolic Syndrome
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to investigate the safety and tolerability of MB12066 after a
      single oral dose and to investigate the pharmacokinetic characteristics of MB12066 after a
      single oral dose.
    

Detailed description: 
      -  Safety/ Tolerability evaluation

           -Adverse events, Physical examinations, Vital signs, ECG (including continuous ECG
           monitoring), Laboratory tests (including hematology, chemistry, coagulation, PBS,
           NAD(P)+/NAD(P)H ratio, urinalysis), CIC

        -  Pharmacokinetic Evaluation

             -  Serial blood samples and urine collections for pharmacokinetic evaluations will be
                conducted between 0 (pre-dose) and 96 hours after a single oral dose.

             -  Blood sampling time pre-dose, 1h, 2h, 3h, 4h, 6h, 8h, 10h, 12h, 16h, 24h, 36h, 48h,
                72h post-dose

             -  Urine collection time 0h - 6h, 6h - 12h, 12h - 24h, 24h - 48h, 48h - 72h

             -  Evaluation parameters AUClast, AUCinf, Cmax, Tmax, t1/2, Vd/F, CL/F, Ae, fe, CLR
    

Intervention name(s): MB12066
Intervention type(s): Drug
Intervention description(s): MB12066 10mg, 100mg/tab. once oral dose MB12066 10, 30, 100, 150, 200mg
Other intervention name(s): beta-lapachone
Intervention MeSH terms: Beta-lapachone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Screening
Keywords: Safety; Tolerability; Pharmacokinetic
Effect on Cognitive Function of a Treatment With Aripiprazole
Condition: Schizophrenia
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 4

Summary: 
      To evaluate the effectiveness of Aripiprazole after 12 weeks of therapy for Schizophrenic
      patients.
    


Intervention name(s): Aripiprazole
Intervention type(s): Drug
Intervention description(s): Tablets, oral, 15 mg, once daily, 12 weeks.
Other intervention name(s): Abilify
Intervention MeSH terms: Aripiprazole
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Turkish Version of Evaluation of the Ability to Sing Easily (EASE-TR)
Condition: Voice Fatigue
MeSH terms: Voice Disorders
Study type: Observational

Summary: 
      The aim of the study is to translate and culturally adapt the Turkish version of the EASE
      (EASE-TR) scale and investigate its validity and reliability.
    

Detailed description: 
      The study consists of two phases. In the first phase of the study, the scale will be
      translated and culturally adapted into Turkish. The second phase involves assessing
      participants and validating the translated scale. In this phase, participants will complete
      the EASE-TR and the severity part of the Vocal Tract Discomfort Scale (VTDS) before and after
      a 1-hour performance. One hundred choir member between the ages of 18 and 65 will be included
      in the study.

      Both construct and criterion validity procedures will be used.Within the scope of construct
      validity, the "Known Groups Validity" method will be used based on variables such as
      experience duration, vocal training status, and the presence or absence of current vocal
      complaints. A comparison of pre- and post-performance EASE-TR scores will be conducted.
      Regarding criterion validity, the correlation between EASE scores and the severity part of
      the VTDS will be examined. For reliability, Cronbach's alpha and test-retest reliability will
      be calculated. The questionnaire will be administered a second time to 30 participants after
      14 days in order to measure test-retest reliability.
    

Intervention name(s): Singing activity
Intervention type(s): Other
Intervention description(s): The singing activity will involve a 1-hour performance, rehearsal, or lesson.
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Participants who sings in a professional or unprofessional choir
      
Keywords: Singing voice; Professional voice users
Dietary Energy Restriction and Metabolic Aging in Humans
Condition: Obesity
Study type: Interventional

Summary: 
      The purpose of this study is to develop an effective calorie restricted diet.
    

Detailed description: 
      This study is a 3-phase investigation designed to test two caloric restriction (CR) regimens
      for participant compliance and variability in metabolic and physiologic effects. Initially,
      and through phase 1 (1 week pre-phase, and 6 weeks phase 1), participants will maintain
      normal habits at home.

      Then for phase 2 (24 weeks), the 44 participants will be randomized to one of two diets (Diet
      HG or Diet LG), which they will consume at either 70% or 90% of baseline energy intake. The
      participants randomized to 90% CR (both diets) will form the control group. All food will be
      provided during this phase, and participants will be required to attend weekly group or
      individual meetings with the behavioral counselor and dietitian, and perform regular
      self-monitoring.

      During phase 3 (24 weeks), participants will prepare their own food at home according to
      their CR regimen and will eat to maintain the CR specified for phase 2. They will continue to
      attend the weekly meetings and to perform self-monitoring.

      Diet HG: a diet based on the USDA Food Guide Pyramid, but with additional emphasis on
      adequate fiber and low energy density foods, including use of whole grains rather than
      refined carbohydrates, limited liquid calories, high variety of low energy items such as
      fruits and vegetables and low variety of high-energy discretionary foods.

      Diet LG: a modification of the HG diet in which low energy density is maintained even though
      the percent of energy from fat and protein is increased (by increased use of high-protein
      foods and foods with high water content) and use of different carbohydrate sources and
      physically intact food items (whole grains, raw fruits and vegetables) to further lower
      glycemic load through reducing the glycemic index (GI). High fiber intakes, low energy
      density, limited use of liquid calories, high variety of low energy items such as fruits and
      vegetables and low variety of high-energy discretionary foods will be the same as for the HG
      diet.
    

Intervention name(s): Dietary composition and energy intake
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Dietary restriction; Caloric restriction
Short Term Effect of Vitamin D Supplementation on the Clinical Outcomes in Patients Undergoing Valve Replacement Surgery
Condition: Cardiac Valve Replacement Complication
Study type: Interventional
Phase: Phase 4

Summary: 
      This study evaluates the effect of Vitamin D supplementation on ICU and hospital LOS in
      patients undergoing valve replacement surgery. Half of the patients will receive
      Alfacalcidol, while the other half-the control group- will be exposed to the same environment
      without receiving alfacalcidol.
    

Detailed description: 
      Vitamin D insufficiency has been reported in more than 80% of critically ill patients,
      hospitalized in intensive care unit (ICU), including cardiac surgical patients. Moreover,
      25(OH)D levels continue to decrease from baseline throughout the hospital stay and resolves
      by 6 months. Vitamin D levels < 20 ng/ml is associated with higher mortality, infection rates
      and prolonged length of ICU saty.

      The discovery of vitamin D receptors (VDR) expressed on cardiac muscle and vasculature,
      released a strong hypothesis suggesting that vitamin D regulates RAAS activity and cardiac
      remodeling.

      The beneficial effects of vitamin D on cardiovascular system, immune function and wound
      healing could be of particular interest in critical care, and patients undergoing valve
      replacement surgery will benefit the most.
    

Intervention name(s): Alfacalcidol 1 MCG Oral Capsule
Intervention type(s): Drug
Intervention description(s): 2 mcg of oral Bone Care© soft gelatin capsules once daily with food starting from the day of admission till the end of hospital stay
Other intervention name(s): Bone care
Intervention MeSH terms: Alfacalcidol; Hydroxycholecalciferols
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: randomized ,controlled, open-label, parallel clinical trial
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: LOS; mediastinitis; secondary myocardial infection
Daytime Profile of Salivary Progesterone
Condition: Infertility, Female
MeSH terms: Infertility; Infertility, Female
Study type: Interventional

Summary: 
      The aim of this study is to perform a 12-hour profile of free saliva progesterone during the
      luteal phase after fresh and frozen embryo transfer. If progesterone levels in saliva samples
      show a constant level during daytime, this non-invasive measurement can be used in future ART
      patients with insufficient progesterone levels who might benefit from additional exogenous
      progesterone supplementation.
    


Intervention name(s): Progesterone analysis in saliva
Intervention type(s): Diagnostic Test
Intervention description(s): Analysis of salava progesterone
Intervention MeSH terms: Progesterone
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Progesterone; Saliva; IVF; Frozen embryo transfer
Digitalis Investigation Group (DIG)
Condition: Arrhythmia; Cardiovascular Diseases; Heart Diseases; Heart Failure, Congestive; Sinus Arrhythmia; Heart Failure
MeSH terms: Heart Failure; Cardiovascular Diseases; Heart Diseases; Arrhythmias, Cardiac; Arrhythmia, Sinus
Study type: Interventional
Phase: Phase 3

Summary: 
      To determine if digitalis had a beneficial, harmful, or no effect on total mortality in
      patients with clinical heart failure and sinus rhythm.
    

Detailed description: 
      BACKGROUND:

      Despite widespread use of digitalis and its availability for nearly two centuries,
      uncertainty surrounded the appropriateness of its role and value in treating congestive heart
      failure patients in sinus rhythm. The study was a multicenter collaborative effort with the
      Department of Veteran Affairs Cooperative Studies Program which provided support for a data
      coordinating center and a pharmacy coordinating center.

      DESIGN NARRATIVE:

      Randomized, double-blind, simple, multicenter, international trial with 186 centers in the
      United States and 116 in Canada. In the main trial, patients with left ventricular ejection
      fractions of 0.45 or less were randomly assigned to digoxin (3397 patients) or placebo (3403
      patients) in addition to diuretics and ACE inhibitors. In an ancillary trial of patients with
      ejection fractions greater than 0.45, 492 patients were randomly assigned to digoxin and 496
      to placebo. Patients were recruited over a three-year period at the 302 centers and followed
      for a minimum of two years. Patient enrollment began in February 1991 and ended in September
      1993. Follow-up ended in December 1995. The main results paper was published in 1997.

      Three substudies were conducted. The quality of life/6-minute walk test substudy determined
      the effect of treatment on a patient's well-being, daily activities, and functional status.
      The Holter/signal averaging electrocardiogram substudy examined the pathophysiology of sudden
      cardiac death. The neurohormonal substudy determined whether long-term administration of
      digoxin attenuated the neuroendocrine response in patients with heart failure.

      The study completion date listed in this record was obtained from the "Completed Date"
      entered in the Query View Report System (QVR).
    

Intervention name(s): digitalis
Intervention type(s): Drug
Allocation: Randomized
Masking: Double
Primary purpose: Treatment
Nutrition21 Study 1
Condition: Nutritional Supplementation
Study type: Interventional

Summary: 
      The purpose of this study is to determine the effects of nooLVL containing arginine and
      inositol supplementation on executive function and memory prior to and following playing
      video games.
    

Detailed description: 
      Gaming or "E-Sports" has become a very popular activity particularly among younger
      individuals. It requires quick reactions, executive function, memory and fine motor skill. In
      E-Sport competitions and tournaments, E-Sport players often play for hours per session over a
      series of days. Thus, the ability to maintain cognitive and executive function, concentration
      and fine motor skill is paramount. Two recent studies have evaluated the effects of ingesting
      bonded arginine silicate (ASI) and ASI with additional inositol on cognitive function. In the
      first study, ASI supplementation (1,500 mg/d for 3 days and 14 days) significantly improved
      the ability to perform complex cognitive tests requiring mental flexibility, processing speed
      and executive functioning. In the second study, adding 100 mg of inositol to the ASI
      significantly improved cognitive function in gamers after playing video games for one hour.
      This study is designed to assess the effects of bonded arginine silicate and inositol
      ingestion on reaction time and cognitive function prior to and following a 1-hour gaming
      challenge.
    

Intervention name(s): Arginine; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Bonded Arginine Silicate; Maltodextrin
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Crossover Intervention Trial
Masking: Double (Participant, Investigator)
Primary purpose: Health Services Research
Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma
Condition: Renal Cell Carcinoma
MeSH terms: Carcinoma; Carcinoma, Renal Cell
Study type: Observational

Summary: 
      detection of Survivin expression in renal cell carcinoma and correlate this expression to
      tumor grade and stage.
    

Detailed description: 
      renal cell carcinoma is the third most prevalent malignant tumor of the genitourinary system.
      deregulation of apoptosis is involved in carcinogenesis by abnormally prolonged cell
      survival, facilitating accumulations of multiple mutations and augment resistance to
      immune-surveillance. Survivin is a member of inhibitor of Apoptosis Protein family (IAPs). it
      play a role in cell cycle regulation by inhibiting apiptosis. Survivin is over-expressed in
      many human neoplasms.
    

Intervention name(s): sectioning and staining of renal neoplasms after nephrectomy operation
Intervention type(s): Diagnostic Test
Intervention description(s): nephrectomy operations will be done to patients diagnosed as having renel tumors
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients with symptoms and signs of renal neoplasms admitted to Sohag University hospital
        and underwent nephrectomy operations. excisional specimens sent to pathology Lab will be
        sectioned and stained by H&E. only cases of renal cell carcinoma will be included in the
        study.
      
Biospecimen description: 
      tissue sections from cases of renal tumors will be preserved in formalin fixed, parraffin
      embedded blocks.
    
Keywords: Renal Cell Carcinoma; Survivin; Immnuohistochemistry
Comparison of One Morphine Sulfate Sustained-Release 200mg Capsule With Two 100 mg KADIAN Capsules Under Fasting Conditions
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The objective of this single-dose, open-label, randomized, two-period crossover study was to
      compare the rate of absorption and oral bioavailability of a test formulation of morphine
      sulfate 200 mg sustained-release capsules manufactured by Alpharma Branded Products Division
      Inc. to an equivalent oral dose of the commercially available reference product, KADIAN 2 x
      100 mg capsules manufactured by Alpharma Branded Products Division Inc. when administered
      after a 10-hour overnight fast.
    


Intervention name(s): morphine sulfate sustained-release capsules; KADIAN (morphine sulfate sustained-release) capsules
Intervention type(s): Drug; Drug
Intervention description(s): 1 x 200 mg, single-dose capsule; 2 x 100 mg, single-dose capsule
Other intervention name(s): Treatment A; Test product; Treatment B; Reference product
Intervention MeSH terms: Morphine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: bioequivalence; morphine sulfate sustained release capsules; KADIAN capsules; 200 mg
Electronic Notification of Teratogenic Risks
Condition: Teratogens; Abnormalities, Drug-Induced; Contraception
MeSH terms: Congenital Abnormalities; Abnormalities, Drug-Induced
Study type: Interventional

Summary: 
      This study will use a factorial design randomized controlled trial to (1)compare
      multi-faceted decision support (intervention) to streamlined clinical alerts (control) and
      (2) evaluate whether collecting information about women's risk of pregnancy using a networked
      tablet computer (intervention) is superior to the way clinicians usually collect this
      information (control).

      Over the course of 1 year, we will abstract data from the electronic medical record when
      study clinicians prescribe teratogenic medications, conduct phone interviews with women
      prescribed medications by participating clinicians, and survey participating clinicians about
      their satisfaction with the decision support they receive. We will use this data to confirm
      our hypotheses that clinicians in the intervention groups will (1) prescribe fewer
      teratogenic medications, (2) be more likely to prescribe contraception when a teratogenic
      medication is prescribed, (3) have more patients report satisfaction with the counseling they
      received, and (4) report more satisfaction with the decision support they received.
    


Intervention name(s): Clinical decision support; stream-lined clinical alert
Intervention type(s): Other; Other
Intervention description(s): multi-faceted decision support; electronic notification that a medication is potentially teratogenic
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Health Services Research
Keywords: Teratogens; Abnormalities, Drug-Induced; Contraception
Effect of Exercise and Wellness Interventions on Preventing Postpartum Depression
Condition: Postpartum Depression
MeSH terms: Depression, Postpartum; Depression; Depressive Disorder
Study type: Interventional

Summary: 
      The purpose of this study is to examine the efficacy of the active interventions (exercise or
      wellness/support intervention) compared to usual care on the prevention of postpartum
      depression among women at risk for depression. The investigators will also examine the
      efficacy of an exercise intervention compared to a wellness/support intervention on
      postpartum depressive symptoms among women at risk for depression.
    

Detailed description: 
      The purpose of this study is to examine the efficacy of exercise and wellness/support
      interventions for preventing postpartum depression. Specifically, 450 sedentary postpartum
      women (2-6 weeks postpartum) with a history of depression prior to pregnancy will be
      randomized to one of three groups each lasting six months: (1) telephone-based exercise
      intervention; (2) telephone-based wellness/support intervention; or (3) usual care.
      Participants will also complete a follow-up assessment session at 9 months. Participants will
      be recruited via online, email, and print advertisements. The investigators will obtain
      healthcare provider consent for each participant prior to randomization. The exercise
      intervention will consist of a theory-based telephone intervention shown to increase exercise
      among postpartum women in a previous study (Lewis et al., 2011). The wellness/support
      condition will be on the same schedule as the exercise intervention and will address several
      topics related to wellness. The usual care condition will receive their choice of the
      exercise or wellness/support condition upon completion of their final assessment. The primary
      dependent variable will be depression as measured by the Structured Clinical Interview for
      DSM-IV Axis I Disorders (SCID-I) and the Edinburgh Postnatal Depression Scale (EPDS).
      Exercise adherence will be assessed using the 7-Day Physical Activity Recall Interview and
      the ActiGraph (i.e., an accelerometer, an objective measure of exercise).
    

Intervention name(s): Exercise; Wellness/Support
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Telephone-based intervention designed to increase exercise among postpartum women.; Telephone-based intervention designed to provide support to postpartum women.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention