Influence of Genetic and Physiological in Weight Loss
Condition: Overweight and Obesity; Chronic Disease
MeSH terms: Overweight; Weight Loss; Chronic Disease
Study type: Interventional

Summary: 
      The study focuses on the influence of polymorphism in the FTO genes rs9939609 and PPARᵧ
      Pro12Ala, oxidative stress and systemic inflammation on changes in body composition and rest
      metabolism induced by HIIT and continuous aerobic programs in obese or overweight
      individuals.
    

Detailed description: 
      Although the positive effects of continuous aerobic training are already well documented in
      the literature on health aspects. The weight loss induced by physical training is still very
      discrete when compared to other antiobesity means. Studies demonstrate an important
      variability in responses to physical exercise, indicating that individuals respond more or
      less to weight loss. Among these aspects, the factors that may influence exercise-induced
      weight loss have not yet been elucidated. Thus, the objective of the study is to analyze the
      influence of polymorphism in the genes FTO rs9939609 and PPARᵧ Pro12Ala, oxidative stress and
      systemic inflammation on changes in body composition and rest metabolism induced by
      continuous and continuous aerobic programs. Healthy individuals with overweight and / or
      obesity, aged 20-45 years, were randomly assigned to three groups: Continuous Aerobic (AC),
      Intermittent High Intensity Training (HIIT) and Control Group (CG). Groups (AC) and (HIIT)
      engaged in a 12-week program. Before the start of the program, at the sixth week and 48 hours
      after the intervention, they performed blood collections, ergospirometry, dual X-ray
      densitometry (DEXA), nutritional assessments. In addition, collection of buccal mucosa was
      performed for genotyping of polymorphisms studied. Initial differences between the groups, as
      well as between the dependent variables studied will be assessed using the two-way ANOVA test
      or its non-parametric equivalent. Correlation and regression tests will be performed to
      verify the influence of the independent variables and the magnitude of the exercise-induced
      weight loss, according to the normality of the data or differences between the standard
      deviations. The hypothesis tested is that genetic and physiological factors influence the
      weight loss independent of the training modality.
    

Intervention name(s): High-intensity interval training; Aerobic exercise moderate intensity; Control Group
Intervention type(s): Other; Other; Other
Intervention description(s): HIIT training is being conducted on a three-day weekly frequency on a stationary bike. The protocol consisted of two weeks of adaptation with 12 weeks of training that alternated between sprints ranging from 30 s to 60 s (> 95% VO2max), and active recovery ranging from 180 s to 120 s (30 W on the bicycle).; The aerobic training is performed in a walking or running mode, with three weeks of adaptation (2x / wk - 20 to 30 minutes / session, <threshold 1) and 12 weeks of training (3 to 5x / wk - 40 to 60 minutes / session, with prescribed intensities between the anaerobic threshold - L1 and the respiratory compensation point - L2).; The control group is participating in lengthening classes to increase the adherence and control of the influencing variables. Classes are being held once a week for 60 minutes.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Experimental, controlled and randomized study.
Masking: None (Open Label)
Primary purpose: Treatment