The Compatibility of Preoperative Endometrial Biopsies With Postoperative Final Pathology in Endometrial Cancer
Condition: Endometrial Cancer Stage; Gynecologic Cancer
MeSH terms: Endometrial Neoplasms
Study type: Observational

Summary: 
      Although there are many studies comparing preoperative and postoperative histological
      diagnoses in the literature, there are no studies evaluating the compatibility of
      preoperative histological diagnoses obtained from different centers with postoperative
      histological diagnoses.Therefore, in our study, we aimed to determine whether preoperative
      pathological specimens need to be re-evaluated in the referenced hospitals by comparing the
      compatibility of endometrial specimens in secondary care and tertiary centers with their
      final pathologies.In our study, we aimed to reveal the under and overdiagnosis rates of the
      preoperative histological diagnoses of our hospitals compared to the final pathology.
    

Detailed description: 
      Medical data of 960 patients diagnosed with endometrial cancer by endometrial biopsy between
      2002 and 2016 were retrospectively analyzed. Of these patients, 41 were excluded from the
      study due to non-surgical treatment, 254 patients having biopsy only in one center
      preoperatively, and lack of medical data in 52 patients.The study included 613 patients who
      had preoperative endometrial biopsy specimens evaluated by two different centers, diagnosed
      with endometrial cancer and treated surgically. Our study was conducted in the gynecological
      oncology department of our university after obtaining the approval of the ethics committee
      numbered 430-2019.The clinicopathological characteristics of the patients were evaluated by
      examining the hospital records of age, gravida, parity, BM (body mass index), menopausal
      status and systemic diseases. Histopathological and clinical features of endometrial cancer
      were reviewed.In this study, endometrial biopsy samples taken in the second stage state
      hospital were re-evaluated by the gynecopathologist working at the university hospital and /
      or the evaluation process was carried out in two steps by examining the repeated endometrial
      biopsy sampling.Patients diagnosed with endometrial cancer were treated surgically in our
      clinic. Endometrial sampling results based on uterine cancer risk groups; While
      histologically endometrioid and nonendometrioid were evaluated in two groups, the greade1-2
      (low risk), greade3 (high risk) of uterine cancer were evaluated in four groups as those
      without malingnancy (benign and premaling lesions).By comparing these preoperative
      histological diagnoses with postoperative surgical final pathology, the accuracy rates for
      histological type and greade were determined. In addition, lower diagnosis, comorbidity and
      higher diagnosis rates compared to final pathology were examined for two different centers.
    

Intervention name(s): re-evaluation of endometrial biopsy samples by a gynecopathologist working at a university hospital
Intervention type(s): Diagnostic Test
Intervention description(s): The endometrial biopsy samples taken at the second stage state hospital were re-evaluated by the gynecopathologist working at the university hospital and / or the repeated endometrial biopsy sampling was examined and the evaluation process was carried out in two steps.
Observational model: Case-Only
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Patients who received treatment in a tertiary care center for cancer of endometry
      
Keywords: preoperative endometrial biopsies; postoperative final pathology; Endometrial Cancer