Impact of Regional Vibration Application and Flow Mediated Dilation on Brachial Artery Hemodynamics
Condition: Vasodilation; Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      Application of vibration has been previously shown to affect tissue perfusion and utilized in
      different branches of medicine. Little is known about the acute impact of vibration
      application on peripheral artery hemodynamics. In this study, investigators intend to assess:

        1. vibration induced hemodynamic changes in brachial artery in non-diabetic patients and
           compare the characteristics of these alterations with flow mediated dilation mediated
           changes in same cohort.

        2. compare the characteristics of vibration mediated hemodynamic alterations in diabetic
           and non-diabetic subgroups.
    

Detailed description: 
      Background and Rationale:

      Vibration application has been previously shown to affect tissue perfusion and utilized in
      different branches of medicine. However, previous studies have mainly focused on the impact
      of vibration on skin perfusion or vibration with active muscle contractions, therefore
      couldn't truly demonstrate acute impact of local vibration application on peripheral
      arteries. In addition to that, as a population that is prone to develop vascular problems, it
      is not known whether diabetic patients have comparable response to vibration application with
      non-diabetic population.

      Objectives:

      In this study, investigators aim to demonstrate and compare hemodynamic alterations in
      brachial artery with paired measurements pre- and post- vibration application and compare the
      characteristics of these changes with those of flow-mediated dilation in a non-diabetic
      cohort. Additionally, differences and similarities in vascular hemodynamic response to
      vibration in diabetic and non-diabetic subgroups are intended to be elucidated.

      Methods:

      Flow mediated dilatation and vibration will be applied after the participants will abstain
      from alcohol, caffeine and nicotine for 24 hours. Flow mediated dilatation (FMD) will be
      induced via 5 min cuff inflation below left elbow at supra-systolic pressures (50mmHg above
      pre-application systolic pressure). Vibration will be applied with a commercially available
      vibration plate to forearm at 20 hz and 3 mm of vertical amplitude for 5 minutes, 30 minutes
      after termination of FMD. Left Brachial artery flow will be measured with pulsed Doppler and
      diameter will be measured via 2D ultrasonographic imaging at 0th, 2nd, 4th, 6th, 8th
      minutes.Throughout the entire application and measurement periods, patients will be
      continuously monitored with electrocardiogram.
    

Intervention name(s): Local Vibration Application Following Flow Mediated Dilation; Flow mediated dilation
Intervention type(s): Device; Other
Intervention description(s): Flow mediated dilatation will be induced via 5 min cuff inflation below left elbow at suprasystolic pressures (50mmHg above preapplication systolic pressure). Vibration is applied with a commercially available vibration plate to forearm at 20 hz and 3 mm of vertical amplitude for 5 minutes, 30 minutes after termination of FMD.; Flow mediated dilatation will be induced via 5 min cuff inflation below left elbow at suprasystolic pressures (50mmHg above preapplication systolic pressure).
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Vibration; Peripheral Artery Hemodynamics; Diabetes Mellitus