Effect of High-intensity Interval Training on Cardiac Function and Regulation of Glycemic Control in Diabetic Cardiomyopathy
Condition: Diabetic Cardiomyopathies; Type2 Diabetes
MeSH terms: Cardiomyopathies; Diabetic Cardiomyopathies; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      According to data of the International Diabetes Federation (IDF), diabetes in general affects
      approximately 415 million people worldwide and this number is still increasing.
      Cardiovascular diseases, one of the major complications of diabetes, are the leading cause of
      mortality and morbidity in the diabetic population. One of the cardiovascular complications
      is diabetic cardiomyopathy, in which structural and functional changes occur in the heart
      impairing cardiac function.

      Exercise training has already proven the benefits on glycemic control in diabetes. This is
      also the case for the effects on cardiac function. However, as results are conflicting, it
      remains unclear which elements of exercise training should be focused on. For instance,
      high-intensity interval training (HIIT) is gaining interest as positive effects are already
      shown on glycemic control. Therefore, the potential of HIIT to improve cardiac function in
      diabetes should be investigated. Further on, the effects of exercise training on cardiac
      function are mainly investigated during rest by the use of transthoracic echocardiography.
      Therefore, as data are lacking, it remains unclear how the diabetic heart functions during
      exercise.

      The aim of the present study is to investigate the effects of different training modalities
      (e.g. HIIT) on heart function in diabetes both during rest and during exercise itself.
      Therefore, cardiac function will be evaluated by the use transthoracic (exercise)
      echocardiography. This will be combined by the evaluation of several biochemical parameters.

      The results will provide more insight in the pathology of diabetic cardiomyopathy as well as
      the potential of exercise training for this cardiovascular complication. Eventually, this
      research will contribute to the optimization of exercise programs for patients with diabetes.
    


Intervention name(s): high-intensity interval exercise training (HIIT); moderate-intensity exercise training (MIT)
Intervention type(s): Other; Other
Intervention description(s): This program includes 24 weeks of exercise training and is divided in different phases (phase 1: week 1-2, equal to the MIT group, phase 2: week 3-6, 6 bouts of high-intensity exercise, phase 3: week 7-12, 7 bouts of high-intensity exercise, phase 4: week 13-24, 8 bouts of high-intensity exercise). The exercise training program consists of 3 exercise sessions per week (for 6 months).; This program includes 24 weeks of exercise training and is not devided in phases. The exercise training program consists of 3 endurance exercise sessions per week (for 6 months). The total exercise volume equals the exercise volume of the HIIT group.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Type 2 diabetes; Diabetic cardiomyopathy; Cardiac function; Exercise echocardiography; Exercise training