The Impact of Anxiety or Depression on the Sedative Concentration of Propofol
Condition: Anxiety; Depression; Propofol; Anesthetics, Intravenous
MeSH terms: Depression; Depressive Disorder; Anxiety Disorders
Study type: Observational

Summary: 
      120 consecutive female patients, 18-65 years old, American Society of Anesthesiologists (ASA)
      physical status I to II, scheduled for hysteroscopic surgery under propofol-based intravenous
      anesthesia will be recruited in this cohort study. The day before surgery, participants will
      be assessed the state of preoperative anxiety and depression. On the day of surgery, propofol
      will be administered by target controlled infusion (TCI) pump. During induction of
      anesthesia, the level of sedation will be evaluated. The induction dose of propofol, target
      effect-site concentration(Cet), plasma concentration(Cp) and effect-site concentration (Ce)
      of propofol will be recorded.
    

Detailed description: 
      120 consecutive female patients, 18-65 years old, American Society of Anesthesiologists (
      ASA) physical status I to II, scheduled for hysteroscopic surgery under propofol-based
      intravenous anesthesia will be recruited in this prospective cohort study. The day before
      surgery, participants were asked to complete the modified HADS questionnaire in an isolated
      calm room, and the score was used to assess the patients' anxiety and depression level in the
      past 6 months. On the day of surgery, propofol (Fresenius Kabi Austria GmbH, Graz,
      Austria)was administrated by using an intravenous target controlled infusion (TCI) pump
      (Alaris PK, Basingstoke, UK) with Schnider kinetic model. The initial effect-site
      concentration (Ce) was set as 1.0 μg/ml. After the TCI system displayed that Cp and Ce were
      at equilibrium, the target concentration of propofol was increased by an increment of 0.5
      μg/ml until the patients achieved the three desired levels of sedation.The Ce and dose of
      propofol and the consuming time were recorded.
    

Intervention name(s): anxiety and depression
Intervention type(s): Other
Intervention description(s): Female patients who have a previous history of surgery or infertility, or a history of miscarriage or abortion are often susceptible to preoperative anxiety or depression. We will observe the effect of anxiety and depression on the dosage of propofol during induction.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Female patients, 18-65 years old, American Society of Anesthesiologists （ASA） physical
        status I or II, scheduled for hysteroscopic surgery under propofol-based intravenous
        anesthesia in the first affiliated hospital of Sun Yat-sen University in Guangzhou, China
        will be recruited in this cohort study.
      
Biospecimen description: 
      An intravenous cannula was placed and 5 ml blood sample was drawn from each patient. The
      serum was separated and immediately stored at -80℃ for later analysis.
    
Keywords: Female; Prospective Studies; Anesthetics, Intravenous; Propofol; Anxiety/*psychology; Depression/*psychology