bioihbjkbjnl/mcl2 huggingface dataset:
Treatment In Acute Benign Paroxysmal Positional Vertigo
Condition: Benign Paroxysmal Positional Vertigo; Balance; Distorted; Vestibular Disorder; Dizziness
MeSH terms: Vertigo; Benign Paroxysmal Positional Vertigo; Vestibular Diseases; Dizziness
Study type: Interventional

Summary: 
      Benign paroxysmal positional vertigo (BPPV) is a vestibular disorder that manifests itself as
      a result of dizziness caused by the otoconia in the inner ear coming out of their places and
      circulating freely in the semicircular canals or by attaching to the cupula and sensitizing
      the cupula to head movements against gravity. The aim of the study is to compare the
      effectiveness of pharmacological treatment initiated by the physician and vestibular
      rehabilitation initiated by physiotherapist in patients with acute benign paroxysmal
      positional vertigo (BPPV). Thirty patients, aged 18-50 years, who applied to the Bağcılar
      Safa Hospital, were included in the study. The patients were divided into two groups, 15
      pharmacological control group and 15 vestibular rehabilitation group. 8 patients in the
      pharmacological control group were given the drug containing betahistine by the physician,
      and 7 patients received the drug containing additional dimenhydrinate to the betahistine. In
      the rehabilitation group, exercises including head and eye movements and maneuvering were
      performed according to the direction of the canal after the exercise, and the patients were
      given a home exercise program. Treatment continued for 4 weeks. Visual Analogue Scale (VAS),
      dynamic visual acuity test, romberg, semitandem, tandem posture tests with a stopwatch,
      standing test on one leg with eyes open and closed, and unterberger tests were applied to
      patients before and after treatment.
    


Intervention name(s): Vestibular Rehabilitation
Intervention type(s): Other
Intervention description(s): Vestibular Rehabilitation which is consist of repetitive exercises and canalit repositioning maneuvers
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Benign Paroxsymal Positional Vertigo; Balance; Pysiotherapy and Rehabilitation; Canalith Repositioning Procedure; Pharmacological Therapy; Dynamic Visual Acuity; Dizziness
A Relative Bioavailability Study of Propranolol HCl 160 mg Tablets Under Non-fasting Conditions
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to compare the relative bioavailability of Propranolol
      Hydrochloride Extended Release Capsules 160 mg (Actavis) with that of INDERAL® LA 160 mg
      Capsules (Wyeth Pharmaceuticals) following a single oral dose (1 x 160 mg) in healthy adult
      volunteers under non-fasting conditions.
    

Detailed description: 
      Study Type: Interventional Study Design: Randomized, single dose, two-way crossover study
      under non-fasting conditions

      Official Title: A Relative Bioavailability Study of 160 mg Propranolol Hydrochloride Extended
      Release Capsules Under Non-Fasting Conditions

      Further study details as provided by Actavis Elizabeth LLC:

      Primary Outcome Measures:

      Rate and Extend of Absorption
    

Intervention name(s): Propranolol Hydrochloride Extended Release Capsules 160 mg; INDERAL® LA 160 mg Capsules, single dose
Intervention type(s): Drug; Drug
Intervention description(s): A: Experimental Subjects received Actavis formulated products under non-fasting conditions; B: Active comparator Subjects received Wyeth Pharmaceuticals formulated products non-under fasting conditions
Other intervention name(s): Propranolol; Propranolol
Intervention MeSH terms: Propranolol
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: Bioequivalence; Propranolol; Healthy subjects
Oxygen Reserve Index Validation for RD Lite Sensors
Condition: Healthy
Study type: Interventional

Summary: 
      Oxygen Reserve Index (ORI) is a parameter that provides information on arterial partial
      pressure of oxygen (PaO2). In this study, the PaO2 is varied by controlling the concentration
      of oxygen the study volunteer breathes. The ORI device measurement is analyzed by comparing
      it to the PaO2 measurements from a laboratory analyzer.
    


Intervention name(s): Oxygen Reserve Index - RD Lite Sensors
Intervention type(s): Device
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Retroperitoneal Packing or Angioembolization for Hemorrhage Control of Pelvic Fractures
Condition: Shock, Hemorrhagic; Fractures, Bone; Multiple Trauma
MeSH terms: Hemorrhage; Shock, Hemorrhagic; Fractures, Bone; Hip Fractures; Multiple Trauma
Study type: Interventional

Summary: 
      This study is designed to answer whether minimal invasive vessel clotting (angioembolization)
      or open surgery (retroperitoneal packing) is more effective for pelvic fractures with massive
      bleeding. Patients admitted at daytime (7am-5pm) are treated with angioembolization while
      patients admitted at nighttime (5pm to 7am) are treated with open surgery.
    

Detailed description: 
      In patients with pelvic fracture uncontrollable bleeding is the major cause of death within
      the first 24h after injury. Early hemorrhage control is therefore vital for successful
      treatment. Nowadays, recommended techniques for hemorrhage control in pelvic fractures are
      retroperitoneal pelvic packing and angioembolization, dependent upon the available technical
      staff and resources and the condition of the patient.

      Retroperitoneal pelvic packing, on the one hand, is a relatively simple method in controlling
      pelvic hemorrhage even with limited resources. Since 89% of pelvic fracture hemorrhage
      originates from venous bleeding, fracture stabilization and compressive hemostasis by packing
      is a reasonable approach. Angioembolization, on the other hand, has great high effectiveness
      with regard to bleeding control, but requires an angiography suite and technical staff. Since
      hemostasis of retroperitoneal venous bleeding often can be achieved by external pelvic
      fixation, angioembolization is required for the 11% arterial bleedings which are hard to
      control by packing. Even though many authors see both methods as complements, time is crucial
      in the multitrauma setting and the severely injured patient does not tolerate multiple
      interventions well. Until now good predictors for treatment choice are unavailable, and
      management of hemodynamically unstable pelvic fractures remains a matter of debate.

      This study was designed to answer following questions:

        -  Is retroperitoneal pelvic packing or angiography superior with regard to in-hospital
           mortality, complications, required secondary procedures, or post-intervention blood
           loss?

        -  Which of these methods is the more rapid intervention in the acute setting?
    

Intervention name(s): PACKING; ANGIO
Intervention type(s): Procedure; Procedure
Intervention description(s): By retroperitoneal access the space in front of the pelvic fracture is compressed with surgical towels, which stops effectively venous bleeding; Using en endovascular approach, bleeding arteries are identified and clotted using embolizing agents, or coils.
Other intervention name(s): retroperitoneal pelvic packing; angioembolization
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During Sleep in High Altitude
Condition: Environmental Sleep Disorder; Cheyne-Stokes Respiration; Altitude Sickness
MeSH terms: Cheyne-Stokes Respiration; Altitude Sickness; Sleep Wake Disorders; Dyssomnias
Study type: Observational

Summary: 
      One of the major challenges in adapting to high altitudes is that with increasing altitude
      sleeping quality declines rapidly. Thus, the night sleep can only provide limited to none
      regeneration. It usually takes a prolonged stay at a constant altitude to adapt sufficiently
      to the altitude and to have a refreshing night sleep. 1975 Reit et. al showed in their
      EEG-recordings that the sleep architecture (the regular succession of the particular sleep
      phases) is disturbed by repeating arousals which occur due to an irregularity in the
      breathing rhythm.

      The purpose of this study is to create a better understanding of the underlying mechanisms
      that lead to failed acclimatization and AMS, due to sleep disturbance.
    

Detailed description: 
      Under sea level conditions humans breath between 10 and 12 times per minute. The breathing
      cycle in high altitude is accelerated. If the conscious breathing control vanishes during
      sleep a periodic breathing with alternating episodes of hyperventilation and apnea is the
      result. This circumstance causes repetitive arousals that do not allow a normal sleep
      pattern. The associated adverse effects are fatigue, slow or failed acclimatization,
      weakening of the immune system, lack of motivation and the disability to make rational
      decisions.

      Sleep deprivation is a common reason for the abortion of a trip, accidents and severe forms
      of Acute Mountain Sickness (AMS).
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        participants of an expedition to Mount Kilimanjaro
      
Keywords: high; altitude; acute; mountain; sickness; sleep; disorder; periodic; breathing; hyperventilation; apnea
Single Blind Cross-over Dose Response Study in Subjects of Two Inhalers of Salmeterol and Fluticasone Propionate
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to test the body's response to several doses of two different
      inhalation products in healthy volunteers.
    

Detailed description: 
      Healthy subjects will be enrolled and will receive 2, 6, and 12 inhalations from both the
      test and reference pMDI products according to a six-period cross-over design.
      Electrocardiograms (ECGs) and plasma potassium and glucose levels will be measured pre-dose
      and over 6 hours post-dose.
    

Intervention name(s): Salmeterol; fluticasone propionate
Intervention type(s): Drug; Drug
Intervention description(s): A, D 2 puffs; B, E 6 puffs; C, F 12 puffs; A, D 2 puffs; B, E 6 puffs; C, F 12 puffs
Other intervention name(s): Sirdupla; Seretide Evohaler; Sirdupla; Seretide Evohaler
Intervention MeSH terms: Fluticasone; Xhance; Salmeterol Xinafoate; Fluticasone-Salmeterol Drug Combination
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: long-acting beta agonist (LABA); corticosteroid; pMDI; inhaler
Low Level Laser Light Therapy and Chronic Neck and Shoulder Pain
Condition: Shoulder Pain; Neck Pain; Musculoskeletal Pain; Musculoskeletal Strain; Musculoskeletal Sprain
MeSH terms: Shoulder Pain; Musculoskeletal Pain; Neck Pain
Study type: Interventional

Summary: 
      The purpose of this study was to determine whether the application of low level laser light
      therapy to the neck and shoulder region is effective in reducing chronic neck and shoulder
      pain of musculoskeletal origin.
    

Detailed description: 
      Chronic neck and shoulder pain arising from osteoarthritis, chronic muscle spasms or thoracic
      or cervical spine sprain strain can be seriously debilitating. Currently available treatment
      options such as pain relief medication, ice pack, massage, physical therapy and chiropractic
      are typically of limited effectiveness. More permanent options such as surgery are invasive
      with long recovery periods and side-effects and complications of their own. Low level laser
      light therapy, with its proven anti-inflammatory ability, offers a simple non-invasive option
      for the reduction of chronic neck and shoulder pain.
    

Intervention name(s): Erchonia PL2000; Placebo laser
Intervention type(s): Device; Device
Intervention description(s): The Erchonia PL2000 Laser emits 1 mW of red (635nm wavelength) light via an electric diode energy source. It is a hand-held device that uses rechargeable batteries or a separate power adapter.; Inactive laser light
Other intervention name(s): Erchonia PL5000; Erchonia EVRL Laser
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: chronic pain; neck; shoulder; musculoskeletal origin
Effect of Kinesio Taping on Upper Extremity Performance in Individuals With Rounded Shoulders
Condition: Shoulder Pain
MeSH terms: Shoulder Pain
Study type: Interventional

Summary: 
      The objective of this research is to study the effect of kinesio tapes with functional
      correction technique in combination with exercise management to increase strength and
      decrease pain, in people with rounded shoulders. The study would be evaluated with the
      EvaltechTM machine, (functional capacity assessment).
    

Detailed description: 
      Participants

        -  Age 25-50 years, male and female

        -  People who have a shoulder condition. (By measuring in the supine position, distance
           from the posterior aspect of acromion to the bed> 1 inch on both sides)

        -  People with moderate to severe neck and shoulder pain (VAS> 3)

        -  People who have to use their arms for work Overall more than 3 hours per day

      For attaching the tape, the researcher will prepare a replacement shirt in case the For the
      convenience of tape, the experimental group, trained by Certified Kinesio tape, attached the
      kinesio tape. Attaching the tape By using functional correction techniques, apply from the
      front of the acromion process to the spinous process T10 on both sides.

      Measurements

        1. The pressure of (average of peak force) of both arms (pounds)

        2. The pulling force (average of peak force) of both arms (pounds)

        3. Time of overhead endurance test (TMT) (seconds)

        4. Visual analog scale (VAS)

        5. The distance from the posterior aspect of acromion to the bed (inches)

      process of measuring the evaluation 3 times

        1. st after physical therapy treatment Before attaching the kinase tape

        2. nd evaluation period was 48 hours apart before the next treatment.

        3. rd evaluation period is 1 week apart.
    

Intervention name(s): Kinesio tape, functional correction technique; Elastic band strengthening shoulder exercise
Intervention type(s): Other; Other
Intervention description(s): According to Kinesio Taping, functional correction technique could use for correcting shoulder, scapular alignment and decrease pain.; The exercise in which both groups will receive Introduction of exercise with rubber bands (Elastic band) It is a home exercise (Home base exercise program) for patients to do with appropriate resistance. Which can be done at least 10 times and not more than 20 times continuously,will be asked to do all 3 positions.
1) Shoulder external rotation in shoulder abduction 90 degrees 2) Shoulder horizontal abduction in shoulder abduction 90 degrees 3) Seated bend row, which will be done 15 times, each hold for 10 seconds, do 3 sets, each set rest 2 minutes, 2 times a day ( Morning-evening) consecutively for 1 week
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: RCT among two groups,
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Kinesio tape, Functional correction, Rounded shoulder
Pediatric Endotracheal Intubation
Condition: Cardiac Arrest; Intubation, Endotracheal
MeSH terms: Heart Arrest
Study type: Interventional

Summary: 
      We hypothesized that the McGrath MAC EMS is beneficial for intubation of pediatric manikins
      while performing CPR. In the current study, we compared effectiveness of the McGrath MAC EMS
      and MIL laryngoscopes in child resuscitation with and without CC.
    


Intervention name(s): McGrath; MIL
Intervention type(s): Device; Device
Intervention description(s): video-laryngoscopy; direct-laryngoscopy
Other intervention name(s): McGrath MAC EMS; Miller Laryngoscope
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Effect of Volitional Pursed-lips Breathing
Condition: COPD
Study type: Interventional

Summary: 
      Simulation of pursed-lips breathing by defined stenoses in pulmonary function diagnostics to
      quantify the effect of the pursed-lips breathing
    

Detailed description: 
      Since many years it is recommended for COPD patients to reduce the crossdiameter of the lips
      in order to improve the exhalation by means of so-called pursed-lips breathing (PLB). But the
      effects have never been studied quantitatively. In this study, the PLB effect is simulated
      during lung function diagnostics, using different sized resistors inserted into the routine
      mouthpiece of the flow sensor to resemble the effective airway resistances of a PLB maneuver.
      This prospective, randomized study includes 20 healthy subjects and 50 COPD patients, who
      will perform lung function testing with 4 different sized resistors.
    

Intervention name(s): Baseline; MESH-Resistor 5; MESH-Resistor 10; Perforated Resistor 7; Perforated Resistor 11
Intervention type(s): Other; Other; Other; Other; Other
Intervention description(s): Lung function testing with MasterScreen™ Body, CareFusion Germany GmbH; Lung funtion testing with MasterScreen™ Body, CareFusion Germany GmbH, Mouthpiece with mesh-resistor (5hPa/L) to create laminar airflow; Lung funtion testing with MasterScreen™ Body, CareFusion Germany GmbH, Mouthpiece with mesh-resistor (10hPa/L) to create laminar airflow; Lung function testing with MasterScreen™ Body, CareFusion Germany GmbH, Mouthpiece with perforated resistor (inside diameter 7mm) to create a turbulent airflow; Lung function testing with MasterScreen™ Body, CareFusion Germany GmbH, Mouthpiece with perforated resistor (inside diameter 11mm) to create a turbulent airflow
Other intervention name(s): Rudolph Flow Resistance Standards; HANS RUDOLPH, Inc.; Rudolph Flow Resistance Standards; HANS RUDOLPH, inc; 900MR405; Fisher&Paykel Healthcare; 900MR406; Fisher&Paykel Healthcare
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Pursed-lips Breathing; Resistor
Multi-Center Clinical Evaluation of Two Daily Disposable Contact Lenses (Study 2)
Condition: Refractive Error
MeSH terms: Refractive Errors
Study type: Interventional

Summary: 
      The purpose of this study is to compare the subjective performance of two daily disposable
      contact lenses with respect to comfort and handling.
    


Intervention name(s): Nelfilcon A contact lens; UltraFilcon B contact lens
Intervention type(s): Device; Device
Intervention description(s): Soft contact lens CE-marked for daily disposable wear.; Silicone hydrogel soft contact lens CE-marked for daily disposable wear. Private-label versions may be used.
Other intervention name(s): DAILIES® AquaComfort Plus®; Procornea BYO Air Daily
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: contact lenses; daily disposable contact lenses; silicone hydrogel; contact lens comfort; near-sighted
Investigation of the Effects of a Bifidobacterium Breve Strain on Fat Loss in Healthy Adults
Condition: Obesity; Overweight and Obesity
MeSH terms: Obesity; Overweight
Study type: Interventional

Summary: 
      Overweight has become a critical issue in North America and the market value of weight loss
      products is expected to rise as the population becomes more health-conscious and aware of the
      risks associated with excess body weight. This randomized, placebo-controlled, clinical trial
      investigates the effect of Bifidobacterium breve supplementation with exercise intervention
      on fat loss.
    

Detailed description: 
      In early adulthood, excess body weight is a risk factor associated with several health
      complications later on in life and probiotics have been used for decades for maintaining
      intestinal health, and in recent years probiotics have been proposed for weight management.
      This randomized, placebo-controlled, clinical trial investigates the effect of
      Bifidobacterium breve supplementation with exercise intervention on fat loss.
    

Intervention name(s): B. breve; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Probiotic capsule. Participants will be instructed to take 2 capsules of placebo for 4 weeks during the run-in period. On day 1 participants will be instructed to take 2 capsules of B. breve B-3 in the morning before breakfast for 12 weeks.; Placebo capsule. Participants will be instructed to take 2 capsules of placebo for 4 weeks during the run-in period. On day 1 participants will be instructed to take 2 capsules of placebo in the morning before breakfast for 12 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Portion-controlled Diet Will Prevent Weight Gain in Diabetics Treated With ACTOS
Condition: Diabetes Mellitus
MeSH terms: Weight Gain
Study type: Interventional
Phase: Phase 4

Summary: 
      We hypothesized that a portion controlled diet would prevent the weight gain associated with
      the use of a peroxisome profliferator-activated receptor-gamma (PPAR-g). This is a 4 months
      randomized clinical trial in type 2 diabetics who are treated with pioglitazone and a
      standard diet, pioglitazone and a portion-controlled diet and metformin with a standard diet.
    

Detailed description: 
      A total of 60 male and female type 2 diabetic subjects will be recruited and randomized into
      1 of 3 treatment groups for the 4 months long trial

        1. ACTOS plus a standard diet

        2. ACTOS plus a portion-controlled diet

        3. Metformin plus a standard diet. The end-point of the trial is the change in body fat
           content from baseline to the end of the trial
    

Intervention name(s): Actos plus standard diet; Actos plus structured diet; Metformin plus standard diet
Intervention type(s): Other; Other; Other
Intervention description(s): Actos plus standard diet; Actos plus structured diet; Metformin plus standard diet
Intervention MeSH terms: Metformin; Pioglitazone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment