Bowel Preparation Before Rectal Cancer Surgery
Condition: Rectal Cancer
MeSH terms: Rectal Neoplasms
Study type: Interventional

Summary: 
      Traditionally bowel preparation before surgery of rectal cancer could be troublesome for
      patients especially for patients with kidney and cardio- vascular diseases, where salt and
      electrolyte balance can be a problem.

      Cleaning the bowel without complications for the patient is one of the aims for this study.

      The other aim is to see if patient nutritional status improves with nutritional drinks as a
      complement to food intake 4-6 weeks before surgery.
    

Detailed description: 
      In our institution, patients undergoing surgery for cancer in the rectum are often prepared
      with energy drinks in order to receive a higher energy level before the operation. As a
      result of this the patients often avoid nausea and have a better intestinal function after
      surgery and less complications. We think that this treatment has worked well on the patients
      but no scientific studies have been done on these patients. As a complementary result of the
      treatment with nutritional drinks we have found that the colon is empty already after a short
      time of treatment.

      The actual study's purpose is to find out if rectal cancer surgery can be performed without
      traditionally bowel preparation. Nutritional drinks are to be used instead of traditional
      bowel preparation. Patients are randomized into two groups, stratification for stricture,
      malnutrition and laparoscopic surgery and each group should either bee treated with
      traditional bowel preparation, Laxabon® (A) or nutritional drinks, Fresubin Energy drink (B)
      before surgery. Patients in subgroup B take nutritional drinks seven days before surgery
      instead of ordinary food. Bowel purity degree is measured peroperatively.

      The secondary aim is to see if malnutrition can be improved with nutritional drinks as a
      complement to ordinary food intake before surgery. For four to six weeks before surgery 50 %
      or more of the caloric need is substituted with nutritional drinks in subgroup B (Fresubin
      Energy drink 15-30 kcal/kg*day). Subgroup A only eats ordinary food throughout the same
      period, before surgery.

      Bowel purity degree, physiological functions, and body mass index are measured in all four
      groups before and after surgery. All patients in the study keep records of physical activity
      daily, and food diary twice a week. Complications are registered.

      Blood samples for hormones and electrolytes are taken before and after surgery.
    

Intervention name(s): Fresubin Energy Drink; Laxabon®
Intervention type(s): Dietary Supplement; Drug
Intervention description(s): Fresubin energy drink 30 kcal/kg*dag-1, seven days before surgery; Laxabon® 4 litres starting the day before surgery
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: patients with rectal cancer undergoing surgery; Bowel purity degree; Bowel preparation; Rectal cancer; Nutritional status; complications with traditional bowel preparation; Complications; Physiological status