bioihbjkbjnl/mcl2 huggingface dataset:
Blood Levels of Sevoflurane and Desflurane
Condition: Anesthetics, Inhalation
MeSH terms: Respiratory Aspiration
Study type: Observational

Summary: 
      16 patients with American Society of AnesthesioIogy (ASA) physical status I-III will
      recruited to this study. Patients will divided to the 2 groups. %1.5 Sevoflurane will apply
      in Group S and %6 Desflurane will apply in Group D. Each groups will divide 2 subgroups. Two
      lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be
      performed to Group Sb and Group Db. At the time point 40.minutes first blood sample will
      given from patients. Blood sample will be taken at intervals of 10 minutes from groups of two
      lung ventilation. In groups of one lung ventilation, blood samples will be taken at the time
      interval of 10 minutes after one lung ventilation started. All blood samples will be assess
      in Gas Chromatography.
    

Detailed description: 
      Investigator aimed to assess blood level of sevoflurane and desflurane during two lung
      ventilation and one lung ventilation. The investigators will use Gas Chromatography for
      define drugs levels. 16 patients with ASA I-III patients who undergo thoracotomy and
      abdominal surgery will be recruited to this study. Patients will divided in to the 2 groups.
      %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D during
      anesthesia maintenance. Each groups will divide 2 subgroups which are one lung ventilation
      groups and two lung ventilation groups. Two lung ventilation will be performed to Group Sa
      and Group Da, one lung ventilation will be performed to Group Sb and Group Db. Sequential
      blood samples will be taken from both arterial and central venous canula at the same time
      point. First blood samples will be taken at 40. minutes of anesthesia. Sequential samples
      will be taken at interval of 10 minutes during two lung ventilation. In one lung ventilation
      second blood samples will be taken at the 10. minutes of one lung ventilation. After than at
      the interval of 10 minutes, collection of blood samples both arterial and central venous will
      be continue.

      All collection will assess with gas chromatography.
    

Intervention name(s): Sevoflurane; Desflurane
Intervention type(s): Drug; Drug
Intervention description(s): Measurement of blood desflurane level during one lung ventilation; Measurement of blood desflurane level during one lung ventilation
Other intervention name(s): Blood sevoflurane level; Blood desflurane level
Intervention MeSH terms: Sevoflurane; Desflurane
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        16 patients with ASA I-III who undergo thoracotomy or abdominal surgery
      
Keywords: blood sevoflurane concentration; blood desflurane concentration; one lung ventilation
Study Evaluating Absorption, Distribution, Metabolism and Excretion (ADME) of Single Dose [14C] AZD2423 in Volunteers
Condition: Neuroscience
Study type: Observational

Summary: 
      Phase I study to evaluate the excretion of radioactivity, the metabolic profile,
      pharmacokinetics, safety and tolerability following a single oral administration of
      [14C]AZD2423 in healthy male volunteers aged 50 to 65 years (inclusive).The purpose of this
      study is to investigate how and how quickly AZD 2423 or its break down products are excreted
      by analysing blood, faeces and urine samples collected during the study.
    


Intervention name(s): AZD2423
Intervention type(s): Drug
Intervention description(s): AZD2423
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        primary care clinic/community sample
      
Biospecimen description: 
      Pharmacogenetic samples
    
Keywords: Radioactive; ADME; Neuropathic pain
Feasibility and Acceptability of an Educational Intervention to Improve the Management of Depression in Primary Care.
Condition: Patients With Moderate Depression,; First or Second Episode
MeSH terms: Depression; Depressive Disorder
Study type: Interventional

Summary: 
      Qualitative study based on interviews and questionnaires with patients participating to an
      educational intervention to improve the management of depression in primary care.

      Objective is to assess feasibility and acceptability of an educational intervention to
      improve the management of depression in primary care To elaborate an educational program for
      the management of depression in primary care.
    

Detailed description: 
      To assess feasibility and acceptability of an educational intervention to improve the
      management of depression in primary care To elaborate an educational program for the
      management of depression in primary care.

      And perspectives are to elaborate an educational intervention to care depression in primary
      care
    

Intervention name(s): an educational intervention
Intervention type(s): Behavioral
Intervention description(s): To elaborate an educational program for the management of depression in primary care
Intervention model: Single Group Assignment
Masking: None (Open Label)
Keywords: patients; moderate depression
Attention Training and Its Effects on Body Image Disturbance
Condition: Body Dissatisfaction; Eating Disorder Symptoms
MeSH terms: Feeding and Eating Disorders
Study type: Interventional

Summary: 
      Research has consistently found attentional biases towards negative weight-related stimuli in
      individuals with eating disorders. It has been suggested that these biases may act as a
      vulnerability factor for the development and maintenance of body dissatisfaction and may
      therefore be an important target for intervention. Previous studies have demonstrated the
      capacity to modify the patterns of attention allocation to threatening stimuli in a variety
      of anxiety disorders, with a subsequent and sustained reduction in anxiety symptoms. Thus,
      the present study aimed at testing the efficacy of attention training in reducing attentional
      biases and eating disorder symptoms in individuals with elevated levels of body image
      disturbance and eating disorder symptomatology of clinical severity. Thirty-two participants
      were randomly allocated to receive eight sessions of a 10-minute computer task aimed at
      training their attention away from weight-related stimuli or a control placebo training
      condition. Results showed that participants in the attention training group had a
      significantly greater reduction in their attentional bias and body dissatisfaction from pre-
      to post-training relative to the placebo condition. At follow-up, both groups showed a
      significant decrease in body dissatisfaction from their pre-training levels. The only
      significant difference between groups in eating disorder symptoms at follow-up was in terms
      of the attention training group experiencing a greater reduction in weight and shape
      concerns.
    


Intervention name(s): attention training; placebo training
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Glutamate Reducing Interventions in Schizophrenia
Condition: Clinical High Risk for Psychosis
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 1

Summary: 
      Participants will be administered several doses of pomaglumetad (POMA) (low and high doses)
      over 14 days to individuals at clinical high risk for developing psychosis and use magnetic
      resonance imaging (MRI) brain imaging to determine whether these doses of POMA are affecting
      glutamate levels.
    

Detailed description: 
      A double-blind, randomized, phase 1b, multiple dose trial of 14 days of treatment with POMA
      (80 mg, 160 mg, 240 mg, 320 mg) in clinical high risk patients to determine which dose, if
      any, reduces glutamate and metabolism using MRI techniques. The GO NO-GO decision will be
      whether or not any dose tested in the R61 phase of the trial decreases left hippocampal CA1
      region cerebral blood volume (CBV).
    

Intervention name(s): Pomaglumetad methionil
Intervention type(s): Drug
Intervention description(s): metabotropic glutamate 2/3 receptor (mGlu2/3R) agonist
Other intervention name(s): POMA; LY2140023
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Double-blind, randomized, phase 1b, multiple dose trial
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
The Effect of Acupuncture on Anxiety and Working Memory
Condition: Memory Impairment; Anxiety
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      This study endeavors to examine the relationship between acupuncture, anxiety, and
      performance on a test of working memory. In the study, all participants will complete the
      State-Trait Anxiety Inventory (STAI) survey to determine how anxious they are at the moment
      and how anxious they tend to be in general. Then ½ of subjects will receive acupuncture for
      20 minutes and ½ will rest quietly for 20 minutes. After this period, all subjects will again
      complete the STAI survey. Then all subjects will complete the Automated Operations Span Task
      (AOSPAN) which is a computerized test of working memory. Statistical analysis will be
      performed to determine if acupuncture had any effect on State-level anxiety and on
      performance on the AOSPAN.
    


Intervention name(s): Acupuncture
Intervention type(s): Procedure
Intervention description(s): After completing questionnaires and anxiety survey, a licensed acupuncturist will insert needles according to Clean Needle Technique into specific acupuncture points. Procedure will last 20 minutes.Following acupuncture treatment, participants will complete anxiety survey and memory test.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Acupuncture; anxiety; memory
Investigation of the Effect of Internet Addiction Level in University Students
Condition: University Students
MeSH terms: Behavior, Addictive; Internet Addiction Disorder
Study type: Observational

Summary: 
      The internet, which has become a part of our daily life; serves many purposes such as quick
      access to information, e-mail, and chat, banking and shopping, having a good time, using
      social networking sites. Internet addiction, which was first defined by Ivan Goldberg in
      1996, is defined as the inability to control internet use, which causes pressure, feelings of
      anxiety, and dysfunctional behaviors in daily life activities. Social media, digital games
      and smartphone addiction are among the addiction types whose active ingredient is the
      internet, and internet addiction is expressed as a whole, regardless of the type of addictive
      application or activity. Considering that internet use is common among young people, one of
      the risk groups in terms of internet addiction is university students. As a matter of fact,
      Günay et al. stated that approximately 8% of university students are at risk of internet
      addiction.

      In the literature, musculoskeletal problems and pain in the thumb and related joints,
      reduction in pinch strength, and hand function have been reported with smartphone use. In
      addition, a significant relationship was found between the time spent surfing the Internet
      and pain at the base of the thumb. However, to the best of our knowledge, no study has been
      found that examines the effect of internet addiction level on thumb pain threshold, hand
      strength and manual dexterity in university students. The aim of our research is to determine
      the level of internet addiction in university students and to examine the effect of internet
      addiction level on thumb pressure pain threshold, hand strength and manual dexterity.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Students aged between 18-25 and studying at Bandırma Onyedi Eylül University
      
Keywords: Internet Addiction; Pain Threshold; Hand Strength; Manual Dexterity
Cardiac Output Pulmonary Arterial Catheter Compared to FloWave™ 1000
Condition: Congestive Heart Failure; Ischemic Cardiomyopathy; Mitral Valve Prolapse; Mitral Regurgitation; Aortic Valve Disease; Tricuspid Regurgitation
MeSH terms: Heart Failure; Cardiomyopathies; Mitral Valve Insufficiency; Tricuspid Valve Insufficiency; Aortic Valve Disease; Mitral Valve Prolapse; Prolapse
Study type: Observational

Summary: 
      The purpose of this study is to compare cardiac output results obtained using the
      thermodilution push technique with the Pulmonary Arterial Catheter (PAC) to the predicted
      cardiac output results obtained from the non-invasive FloWave™ 1000 device.
    


Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Any patient that has a Swan Ganz PAC catheter in place.
      
Keywords: Non-invasive Cardiac Output
Effectiveness of Aerobic Exercises on the Autistic Children
Condition: Autism Spectrum Disorder
MeSH terms: Autism Spectrum Disorder
Study type: Interventional

Summary: 
      Autism spectrum disorder (ASD) is a neurodevelopmental disorder manifesting stereotypic
      behaviors and problem in communication and social interaction. Different physical therapy
      interventions like aerobics help to improve recurrent behaviors and task performance of
      autistic children. This study was focused to see the effect of jogging on the stereotypic
      behaviors and task performance of autistic children. A single blinded randomized study was
      conducted on 38 autistic children, randomly allocated to two groups, performing jogging and
      ball exercises. Repetitive Behavior Scale-revised(RBS-R) and Jebsen Hand Function Test (JHFT)
      was used for assessment. Exercise was performed for 3 weeks and 4 sessions per week.
    


Intervention name(s): Aerobic Exercise; Ball Exercises
Intervention type(s): Procedure; Procedure
Intervention description(s): Jogging was performed for 20 minutes. Jogging was performed by experimental group for 3 weeks and 4 sessions per week.; Ball exercises like stability ball roll, stability ball hug, stability ball catching, ball throwing and ball tapping exercises were for 10 minutes. Ball exercises was performed by both groups for 3 weeks and 4 times per week .
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: Autism spectrum disorder; Physical therapy; Stereotypic behaviors; ASD; Repetitive behaviors; Aerobic exercises; Jogging; Ball exercises.
Evaluation of Weekly Tafenoquine
Condition: Malaria
MeSH terms: Malaria
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is a phase 2b, placebo controlled, randomized, blinded study of the efficacy of WR
      238605, a new primaquine analog, compared to placebo as chemosuppression of P. falciparum
      malaria in Nyanza Province, western Kenya.
    


Intervention name(s): Tafenoquine; Placebo
Intervention type(s): Drug; Other
Intervention description(s): Tafenoquine 200mg and 400 mg; Placebo
Intervention MeSH terms: Tafenoquine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Exercise Intensity and Type 2 Diabetics
Condition: Type 2 Diabetes
Study type: Interventional

Summary: 
      The purpose of this study is to determine if a single session of aerobic exercise effectively
      controls the blood pressure (BP) of individuals with type 2 diabetes mellitus (T2DM) over the
      24h of post-exercise period, and the effects of intensity of aerobic exercise on these BP
      responses.
    


Intervention name(s): Aerobic exercise
Intervention type(s): Other
Intervention description(s): Intensity of aerobic exercise
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Aerobic Exercise; Blood Pressure
Effect of Easy Sleep Complex Essential Oil Inhalation on Sleep Disorders
Condition: Sleep Disorder
MeSH terms: Sleep Wake Disorders; Parasomnias
Study type: Interventional

Summary: 
      Sleep disorders affect human health tremendously. It has been reported that aromatherapy by
      fragrance inhalation can be used as an adjuvant therapy to modulate parasympathetic nervous
      activity for relieving stress and mood, and promoting sleep quality. Many researches
      confirmed that lavender essential oil can be used as an adjuvant therapy for sleep disorders.
      It can effectively relieve stress and modulate physical and mental status. However, many
      studies about aromatherapy lack sleep detection instruments to objectively confirm their
      effects on sleep physiology. Therefore, this study adopts Easy sleep complex essential oil as
      the experimental group. The lavender essential oil containing orange, petitgrain, rose,
      lavender, rosewood, ho wood, amyris essential oil and lavender oil is chosen as control
      group. The subjects will be randomly assigned to one of the two groups. The efficacy results
      will be evaluated and compared between the two groups. The investigators expect that
      aromatherapy by fragrance inhalation with Easy sleep complex essential oil will improve sleep
      quality more effectively than lavender essential oil.
    

Detailed description: 
      A Randomized, Single-blind, Active-Controlled Trial to Evaluate the aromatherapy by fragrance
      inhalation using Easy sleep complex essential oil in patients with sleep disorders.
    

Intervention name(s): Aromatherapy with essential oil
Intervention type(s): Other
Intervention description(s): the aromatherapy by fragrance inhalation
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: aromatherapy essential oil; Easy Sleep complex essential oil; Lavender essential oil; sleep disorders
Efficacy of MVA-NP+M1 in the Influenza H3N2 Human Challenge Model
Condition: Influenza
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 2

Summary: 
      A Phase 2, single center, randomized, double blind study evaluating the safety, efficacy, and
      immunogenicity of MVA NP+M1 in the H3N2 human influenza challenge model; on healthy adult
      volunteers.
    

Detailed description: 
      The study consists of an outpatient vaccination phase (155 participants), and at least 2
      months later an inpatient challenge phase (134 participants). Participants are randomized
      93:62 to receive either MVA-NP+M1 or Placebo. Up to 20 participants will be challenged over
      several 3-week blocks, and the remainder at the final 3-week block for a total of 80
      MVA-NP+M1 and 54 Placebo recipients challenged.
    

Intervention name(s): MVA-NP+M1; Saline; H3N2 (A/Belgium/2417/2015)
Intervention type(s): Biological; Biological; Biological
Intervention description(s): Trial Vaccine; Sodium Chloride Placebo; Challenge Agent
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Study to Compare the Pharmacokinetics of Mometasone Furoate Alone and in Combination With Indacaterol in Patients ≥ 6 to < 12 Years Old With Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 2

Summary: 
      This clinical study was designed to assess the pharmacokinetics, safety and tolerability of
      single inhaled doses of mometasone furoate (MF) when administered alone via MF Twisthaler®
      (TH) or as an indacaterol acetate/MF fixed dose combination (QMF149) via the Concept 1 (C1)
      device in pediatric asthma patients.
    

Detailed description: 
      This study was an open-label, two-period, single-sequence crossover study that consisted of
      four distinct study periods:

        -  Screening: Participants underwent a screening period of up to 14 days where were
           assessed for eligibility.

        -  First Treatment: On the first treatment visit (Day 1) participants received a single
           inhaled dose of 100 μg MF administered via the TH device followed by a 4-7-day washout
           period.

        -  Second Treatment: On the second treatment visit (Day 6-9) participants received a single
           inhaled dose of 75/40 μg indacaterol acetate/MF fixed dose combination (FDC) (QMF149)
           via C1 (Breezhaler®) device. Participants were allowed to use rescue medication (as
           needed) and potentially their Standard of Care (SoC) asthma therapy (excluding MF and
           indacaterol acetate).

        -  Safety Follow-up: Upon completion of the treatment period, participants were followed up
           for safety assessments for 30 days.
    

Intervention name(s): Mometasone furoate; QMF149; Standard of Care (Soc)
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Single inhaled dose of 100 µg mometasone furoate (MF) administered via Twisthaler® on Day 1; Single inhaled dose of QMF149 (75/40 µg indacaterol acetate/MF fixed dose combination) administered via Concept 1 device on Day 6-9; Asthma therapy: budesonide and salbutamol being the most frequently used (excluding MF and indacaterol acetate)
Other intervention name(s): MF
Intervention MeSH terms: Mometasone Furoate
Intervention model: Single Group Assignment
Intervention model description: Single-sequence crossover study
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: QMF149; mometasone furoate; indacaterol; pediatric; asthma; PK
A Study to Evaluate the Efficacy and Safety of Eptinezumab for the Prevention of Migraine in Participants That Are Not Helped by Previous Preventive Treatments
Condition: Migraine
MeSH terms: Migraine Disorders
Study type: Interventional
Phase: Phase 3

Summary: 
      Evaluation of eptinezumab in the prevention of migraine in participants with unsuccessful
      prior preventive treatments.
    

Detailed description: 
      The total study duration from the screening visit to the completion visit is approximately 76
      weeks and includes a screening period (28-30 days), a placebo-controlled treatment period (24
      weeks) and a treatment extension period (48 weeks).

      The participant will start treatment at the baseline visit and follow a 12-week dosing
      schedule with either eptinezumab (100 or 300 milligrams [mg]) or placebo by intraveneous (IV)
      infusion. Participants who were assigned to placebo in the placebo-controlled treatment
      period, will be randomly allocated to one of two treatment groups: eptinezumab 300 mg or
      eptinezumab 100 mg.
    

Intervention name(s): Eptinezumab; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Eptinezumab, concentrate for solution for infusion 100 mg/milliliter (mL); concentrate for solution for infusion, intravenously
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment