bioihbjkbjnl/mcl2 huggingface dataset:
Chronic Pancreatitis. Effect of Pioglitazone on Endocrine Function, Exocrine Function & Structure, Pain & Life Quality
Condition: Chronic Pancreatitis; Insulin Resistance; Normal or Mildly Abnormal Stool Fat Levels
MeSH terms: Pancreatitis; Pancreatitis, Chronic; Insulin Resistance
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine if study drug (Pioglitazone) treatment will improve
      pre-diabetes (insulin resistance) or ealy diabetes and improve clinical symptoms (pain) or
      laboratory evidence of chronic pancreatitis.

      The goal of the investigators is to gather information from this study to help gain
      understanding of a potential therapy for chronic pancreatitis.
    

Detailed description: 
      The pancreas is a digestive organ that secretes insulin (and other hormones) into the blood
      for regulating blood sugar (glucose) and digestive enzymes into the intestine for digesting
      and absorbing nutrients consumed in meals. Chronic pancreatitis is a progressive clinical
      disease of the pancreas, associated with swelling (inflammation), scarring (fibrosis) and
      loss of normal functioning tissue. Patients develop diabetes mellitus (elevated blood sugar),
      malabsorption of nutrients, weight loss and pain. Presently chronic pancreatitis is
      considered an irreversible condition because the mechanisms responsible for chronic
      pancreatitis are poorly understood and no therapy is proven. However, recent studies provide
      important clues that oral medications (Thiazolidinediones) used to treat diabetes mellitus
      might improve or reverse features of chronic pancreatitis, including elevated sugar or
      diabetes, reduced secretion of digestive enzymes, and pancreatic swelling and scarring.

      Note: Takeda Pharmaceuticals North America (TPNA) provided pioglitazone and placebo pills
      with identically appearance until June 28, 2010, approximately the middle of the study.
    

Intervention name(s): Pioglitazone; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Participants randomized to pioglitazone receive 30 mg taken once daily for 48 weeks.
Other intervention name(s): Actos
Intervention MeSH terms: Pioglitazone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Chronic pancreatitis; Insulin resistance
Measurement of Glucose Metabolism in Humans: Effect of Recurrent Hypoglycemia on Hypothalamic GABA
Condition: Type 1 Diabetes; Healthy
MeSH terms: Hypoglycemia
Study type: Interventional

Summary: 
      You are invited to participate in a study designed to investigate the effects of diabetes
      mellitus, high and low glucose, and high blood insulin on the brain. You were selected as a
      possible participant because you fit into one of the following categories. a) you are either
      healthy and competent, are not pregnant and you have no known medical disease and therefore
      your glucose metabolism will be typical of a normal person, or b) you have diabetes.
    

Detailed description: 
      Glucose is a major fuel for most organs in the human body, particularly the brain. How and
      where the body uses glucose is regulated by a number of hormones, for instance insulin and
      glucagon. In a number of diseases, in particular diabetes mellitus, the glucose supply to the
      brain may be different than normal, which may be a cause for reduced glucose awareness.

      The purpose of this study is to determine the effects of altered glucose metabolism on the
      brain. For example, patients with long duration diabetes mellitus lose their ability to
      secrete the hormones necessary to protect them against hypoglycemia, which may be due to
      alterations in glucose availability to the human brain.

      To measure these effects, we will use intravenous infusions of glucose and insulin.
    

Intervention name(s): hypoglycemia (low blood sugar) and MRI
Intervention type(s): Other
Intervention description(s): hypoglycemia (low blood sugar) and MRI
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Self-Care for Lymphedema in Patients With Breast Cancer
Condition: Breast Cancer
MeSH terms: Breast Neoplasms; Lymphedema
Study type: Observational

Summary: 
      RATIONALE: Identifying why patients don't do self care for lymphedema may help doctors plan
      better at-home self-care treatment.

      PURPOSE: This research study is looking at self-care practices for lymphedema in patients
      with breast cancer.
    

Detailed description: 
      OBJECTIVES:

      Primary

        -  To systematically identify and describe the barriers to completing recommended at home
           self-care of lymphedema in patients with breast cancer.

        -  To identify patient recalled instructions as to at home self-care practices for
           lymphedema as told to them by healthcare professionals and others.

        -  To identify the current at home self-care practices of breast cancer survivors with
           treatment treated lymphedema.

      Secondary

        -  To examine the relationship between at home self-care activities and symptoms in breast
           cancer survivors with lymphedema.

        -  To examine the relationship between at home self-care activities and quality of life in
           breast cancer survivors with lymphedema.

        -  To identify patient-perceived benefits to at home self-care.

      OUTLINE: Patients complete questionnaires about their breast cancer diagnosis and treatment
      history, lymphedema history and problems, and years of education and income. Patients also
      complete surveys about home self-care practices for lymphedema and any benefits, burdens, or
      barriers of at home care.
    

Intervention name(s): questionnaire administration; survey administration; quality-of-life assessment
Intervention type(s): Other; Other; Procedure
Intervention description(s): Completed self-report form; Completed self-report form-other; Completed self-report form qol
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Breast Cancer patients
      
Keywords: male breast cancer; recurrent breast cancer; stage I breast cancer; stage II breast cancer; stage IIIA breast cancer; stage IIIB breast cancer; stage IIIC breast cancer; stage IV breast cancer
The Effects of Thrust Joint Manipulation on the Resting and Contracting Thickness of Transversus Abdominis in Subjects With Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      The primary aim of this study is to examine how different physical therapy interventions
      affect the resting state and contraction state of a certain abdominal muscle in patients with
      low back pain.
    

Detailed description: 
      Patients with low back pain (LBP) will undergo ultrasound imaging of the transversus
      abdominis to measure the muscle thickness at rest and at the contracted state prior to
      intervention and again immediately after intervention. In this randomized controlled trial,
      patients will be randomized into one of two groups. One group will receive the intervention
      of thrust joint manipulation of the lumbar spine and the other group will receive the
      intervention of non-thrust joint manipulation of the lumbar spine.
    

Intervention name(s): Thrust Joint Manipulation of the Lumbar Spine; Non-thrust Joint Manipulation of the Lumbar Spine
Intervention type(s): Other; Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Thrust Joint Manipulation; Non-thrust Joint Manipulation; Transversus Abdominis
Cardiovascular Outcomes Of Diet Counseling
Condition: Coronary Artery Disease; Obesity
MeSH terms: Coronary Artery Disease
Study type: Interventional
Phase: Phase 3

Summary: 
      (1) What effect does behavioral counseling for vegan, for low to moderate fat, and for
      lowered carbohydrate diets have on coronary blood flow? (2) What are the effects of different
      diet protocols when caloric intake and exercise are equalized? (3) Do people, so counseled,
      maintain their modified behaviors after they have completed their diet program? (4) How does
      targeting different diets affect secondary indices associated with heart disease such as
      weight, lipid, inflammatory, and thrombotic factors?
    

Detailed description: 
      Given the current epidemic of overweight and obesity on a global scale ("globesity") and the
      consequent world public health objective of reducing that obesity, it is evident as a
      practical matter that, the main line of attack must be through diet. The public health
      objective and the lack of information regarding the long-term public health effects of
      alternative weight-loss diets motivated this comparative study of the three major types of
      weight-loss diets and their long term effects on coronary blood flow. Secondary endpoints are
      inflammatory and other variables associated with heart disease and obesity.

      Specifically we asked: (1) What effect does behavioral counseling for vegan, for low to
      moderate fat, and for lowered carbohydrate diets have on coronary blood flow? (2) What are
      the effects of different diet protocols when caloric intake and exercise are equalized? (3)
      Do people, so counseled, maintain their modified behaviors after they have completed their
      diet program? (4) How does targeting different diets affect secondary indices associated with
      heart disease such as weight, lipid, inflammatory, and thrombotic factors?
    

Intervention name(s): Medium-intensity Minimally-directive Counseling
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Obesity; Diets; Heart Disease; Randomized controlled trial; Ischemia.
Placebo Effect in the Treatment of Atopic Dermatitis
Condition: Atopic Dermatitis
MeSH terms: Dermatitis, Atopic; Dermatitis; Eczema
Study type: Interventional

Summary: 
      The study is initiated in the indication of atopic dermatitis to study the impact of placebo
      in the treatment of pruritus. Classical conditioning and expectation via
      instructions/anticipation maintain the effect of placebo.
    


Intervention name(s): dimetindene; instruction; conditioning
Intervention type(s): Drug; Behavioral; Other
Intervention description(s): receiving either dimetindene or a placebo (saline) via infusion; information about the drug dimetindene and its efficacy versus no information and unawareness of treatment influencing expectations of an efficient treatment; classical conditioning; experiencing and observing the efficiency of a drug manipulated by a conditioning process versus no learning experience.
Other intervention name(s): learning experience
Intervention MeSH terms: Dimethindene
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Health Effects of Coffee Consumption
Condition: Overweight
MeSH terms: Overweight
Study type: Interventional

Summary: 
      Epidemiological studies have indicated a positive health impact of coffee. Nevertheless,
      intervention studies testing the effect of daily coffee consumption over a longer period are
      lacking so far. Moreover, there is a lack of knowledge about the properties of different
      coffees and their influence on weight development. Therefore, we tested the effect of two
      coffees differing in their alkyl pyridine content over a period of 3 months on weight
      development.
    

Detailed description: 
      Participants were randomly associated to two groups, a test coffee group and a control coffee
      group. After coffee abstinence of 1 months, participants in both groups got a coffee machine
      and coffee pads for three months. Clinical data have been assessed before and after coffee
      abstinence and after 3 months of coffee consumption.
    

Intervention name(s): test coffee; control coffee
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): test coffee with higher alkyl pyridine content; control coffee with regular alkyl pyridine content
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: overweight; body weight; coffee
Oral T7 Oral Testosterone in Man
Condition: Healthy Males; Male Contraceptive
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to test how the body absorbs and processes new forms of oral
      testosterone. Information gained during the study may help develop better forms of
      testosterone therapy in the future.
    

Detailed description: 
      We will be using three drugs: The first, acyline, temporarily turns off the body's production
      of testosterone for about two weeks. Subjects will receive acyline as shots three times over
      a six-week drug administration period. During the time when the body's production of
      testosterone is turned off, we will give testosterone either by itself or with a medication
      called finasteride by mouth twice daily for one week to see how much is absorbed and present
      in the bloodstream after administration. Subjects will go through three one-week study drug
      exposure periods. During two of the three one-week study drug administration periods subjects
      will also take a second medication, finasteride, by mouth twice daily. On the last day of
      each one-week drug administration period, subjects will be admitted to the University of
      Washington General Clinical Research Center overnight for monitoring of your blood
      testosterone levels. There will be 3 overnight visits for this study. This study will allow
      us to determine the absorption of testosterone taken by mouth, and the relative impact of two
      different doses of oral finasteride on testosterone absorption.
    

Intervention name(s): First Intervention (7 days); First Washout (7 days); Second Intervention (7 days); Third Intervention (7 days); Second wash-out period
Intervention type(s): Drug; Other; Drug; Drug; Other
Intervention description(s): Acyline 300mcg/kg subcutaneous (days 1, 15 & 29) + testosterone undecanoate 200 mg, twice daily orally + finasteride placebo; Washout of 7 days between each of the 3 treatment arms; Acyline 300mcg/kg subcutaneous + testosterone undecanoate 200 mg, twice daily orally + finasteride 0.5mg twice daily, orally; Acyline 300mcg/kg subcutaneous + testosterone undecanoate 200 mg, twice daily orally + finasteride 1mg twice daily, orally; Washout of 7 days between each of the 3 treatment arms
Other intervention name(s): propecia; no active drugs; propecia; propecia; no active drug
Intervention MeSH terms: Finasteride
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: 5α-reductase; androgen; dihydrotestosterone (DHT); drug delivery; oestradiol
Pain Perception of People Who Are Unable to Have Headache
Condition: Headache; Pain, Head; Muscle Tenderness; Healthy
MeSH terms: Myalgia; Headache
Study type: Observational

Summary: 
      Headaches are extremely common illnesses with a combined lifetime prevalence of 90-99% in
      Europe. Despite this high prevalence, there are persons who have never, in their whole life,
      encountered a headache.

      The aim of the study is to identify factors that protect against headache by studying pain
      perception, muscle tenderness and pain tolerance in people who never have had a headache
      (headache resistant) versus non-resistant controls.

      The investigators hope to contribute with novelty to the current understanding of headache
      pathophysiology and development of more efficient treatment of headache.

      The investigator examining:

      Quantitative sensory testing (cold pain threshold and heat pain threshold), Muscle tenderness
      (total tenderness score) and cold pressor test (time in the water and pain rating). All tests
      are performed the same day, by one investigator who are blinded to the grouping of the
      participants.
    


Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        50 Headache resistant and 50 non-resistant male participants from the Danish Blood Donor
        Study.
      
Keywords: Headache; Healthy; Muscle Tenderness; quantitative sensory testing; cold pain threshold; heat pain threshold; Total Tenderness Score; Cold Pressor Test; Headache Resistant
Lactoferrin Versus Ferrous Sulphate for the Treatment of Iron Deficiency Anemia During Pregnancy
Condition: Iron Deficiency Anemia of Pregnancy
MeSH terms: Anemia; Anemia, Iron-Deficiency; Iron Deficiencies; Deficiency Diseases
Study type: Interventional

Summary: 
      The study aims to compare the efficacy and the safety of Lactoferrin versus ferrous sulphate
      for the treatment of iron deficiency anemia during pregnancy.
    

Detailed description: 
      The study was done at ainshams university maternity hospital on 100 pregnant women randomized
      in two groups .

      Group one lactoferrin group Group two ferrous sulphate group
    

Intervention name(s): Complete blood count
Intervention type(s): Diagnostic Test
Intervention description(s): To measure hemoglobin difference and serum ferritin levels .
Other intervention name(s): Serum ferritin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Comparison of I-Gel Laryngeal Mask Airway Placement Methods in Elective Surgery
Condition: Effective I -Gel Mask Airway Placement Technique
Study type: Interventional

Summary: 
      To compare the jaw thrust maneuver with the conventional technical methods to place the I-Gel
      laryngeal mask
    

Detailed description: 
      Patients who underwent elective surgery under general anesthesia and who were between the
      ages of 18 and 75 and who had ASA score I-II-III would be included in the study. Patients'
      mallampati scores, thyromental distances, mouth openings will be recorded.

      Patients will be divided into two groups according to supraglottic airway insertion method.

      Both groups will record the insertion time of i-gel, number of trials, operative time,
      placement complications.

      Recorded complications (blood, laryngospasm, etc.) during insertion and removal of
      supraglottic airway devices will be assessed.

      Patients' postoperative sore throat will be questioned and recorded.
    

Intervention name(s): i-gel placement maneuvers
Intervention type(s): Other
Intervention description(s): the i-gel was inserted with triple airway maneuver (mouth opening, head extension and jaw thrust) In the classic maneuver , the index finger used as a guide, pushes the back of i-gel towards the hard palate, inserting it into the pharynx till a resistance is felt and the i-gel is then fixed it its place.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: i-gel; jaw-thrust
Low Intensity 'Blue Light' Treatment of Seasonal Affective Disorder
Condition: Seasonal Affective Disorder
MeSH terms: Mood Disorders; Seasonal Affective Disorder
Study type: Interventional

Summary: 
      One of the most frequently investigated hypothesis of the pathophysiology underlying Seasonal
      Affective Disorder(SAD) or so called winter depression is a disturbance of circadian rhythms.
      Since the circadian system is especially sensitive for the blue portion of the light
      spectrum, a new light therapy device with more blue light (blue enriched polychromatic light)
      was tested for its efficacy to treat SAD. In chronobiological terms this light is
      hypothesized to be more potent in inducing non-visual effects. In the present study
      fluorescent tubes that emit a high portion of short wavelength light on top of the normal
      wavelengths are tested for its superiority in treating SAD. This blue-enriched light (colour
      temperature 17000 ºK) is compared to standard light treatment (5000 º K) in SAD patients.,In
      a earlier study it was shown that the therapeutic effect of blue enriched light were equal to
      standard light treatment using light in both conditions with an intensity of 10 000 lux. In
      the present study, blue enriched light with an intensity of 750 lux was used, because of the
      possible saturation effect in the former study. The investigators hypothesise that blue-
      enriched light with a low intensity improve the therapeutic effects of light treatment
      leading to a higher response or the same response in a shorter time schedule compared to
      standard light treatment.
    


Intervention name(s): Blue enriched light with a low intensity; standard light treatment
Intervention type(s): Device; Device
Intervention description(s): 30 minutes in the morning, 750 lux; standard light treatment, 30 minutes, 10 000 lux
Other intervention name(s): Blue enriched light treatment; Philips energy light HF 3309, 2 lamps PLL36 W 17000 K; Philips Energylight HF 3309, 2 lamps PLL36 W, color 5000K, 10 000 lux
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Seasonal Affective Disorder; phototherapy; circadian rhythms; blue enriched light; melanopsin; low intensity