bioihbjkbjnl/mcl2 huggingface dataset:
Steroids in Bilateral Total Knee Replacement
Condition: Postoperative Inflammatory Response
Study type: Interventional
Phase: Phase 4

Summary: 
      Inflammation related to cytokine release is known to occur with surgery. The cytokine IL6, a
      major marker of inflammation is known to increase during total joint replacement surgery. IL6
      has been found to be elevated postoperatively in patients with hip fractures and has been
      linked to mental status changes and possibly other complications. It is known to lead to
      shock and participate in the inflammatory state seen in sepsis. High levels have further been
      linked to postoperative fever, confusion, symptoms of depression, acute respiratory distress
      syndrome (ARDS) and fat embolism syndrome (FES). Previously the investigators found that low
      dose steroids given in two doses in the initial perioperative period decreased the amount of
      IL6 released compared to placebo, but this was not sustained past 24 hours.

      Desmosine is a stable breakdown product of elastin from lung tissue that can be measured in
      urine samples. It is considered to be a marker of lung injury and is found to be elevated in
      patients with ARDS, congestive obstructive pulmonary disease and FES. Previously, the
      investigators have found that urine desmosine levels rise with bilateral total knee
      replacement compared to unilateral total knee replacement indicating possible lung injury.

      Therefore the investigators hypothesize:

      Continued low dose steroids given three times over a 24 hour period will:

        1. Significantly decrease peak IL6 cytokine release during bilateral total knee replacement
           and maintaining this reduction in IL6 beyond 24 hours.

        2. Decrease urinary desmosine levels, and hence be protective of lung injury.
    


Intervention name(s): Hydrocortisone; Saline
Intervention type(s): Drug; Drug
Intervention description(s): Prepared by pharmacy, 100 mg, IV, every 8 hours, 3 times; Prepared by pharmacy same volume as study drug, IV, every 8 hours 3 times
Intervention MeSH terms: Hydrocortisone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Bilateral total knee replacement; cytokine; desmosine
Impact of Socio-aesthetic Care in the Quality of Life of Patients Treated for Lymphoma During and After Hospitalization
Condition: Lymphoma
MeSH terms: Lymphoma
Study type: Interventional

Summary: 
      In the early 2000s , professional and patient organizations are mobilizing to highlight the
      psychosocial impact of cancer disease , not only during but also after the acute phase.

      In 2003, the government launched the Cancer Plan I reinforced in December 2011 by the Cancer
      Plan II whose objectives include : " Develop a personalized care taking into account the pain
      and psychological and social support " and " increase opportunities for patients to benefit
      from supportive care "and" promote the professional integration .

      This study aims to show that beyond the immediate benefits of the social aesthetic cares in
      hospital (direct soothing, improving the quality of the skin injured by chemotherapy ,
      feeling of escape ... ), these treatments can also affect quality of life for patients during
      and after hospitalization. They also may have an impact on the maintenance of social and / or
      professional satisfactory throughout the planned chemotherapy aplastic period .
    


Intervention name(s): socio-aesthetic care
Intervention type(s): Procedure
Intervention description(s): care of the face
skin cleansing with cleansing milk to remove impurities
a gentle scrub to exfoliate and cleanse the skin
a relaxing massage
moisturizing mask
application of a moisturizer suited to specific patient skin: skin reactivity, dehydration ...
care manicure / pedicure,
massages
makeup, advice (scarves, wigs care products adapted to the skin changes ...) and helping relationship.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Efficacy and Safety Study of Eltrombopag in Pediatric Patients With Thrombocytopenia From Chronic Idiopathic Thrombocytopenic Purpura (ITP)
Condition: Purpura, Thrombocytopaenic, Idiopathic
MeSH terms: Thrombocytopenia; Purpura; Purpura, Thrombocytopenic; Purpura, Thrombocytopenic, Idiopathic
Study type: Interventional
Phase: Phase 2

Summary: 
      Phase II, multi-center, 3 part, staggered cohort, open-label and double blind, randomized,
      placebo controlled study involving 3 age-determined cohorts (Cohort 1: between 12 and 17
      years old; Cohort 2: between 6 and 11 years old; Cohort 3: between 1 and 5 years old). Daily
      dosing with eltrombopag will begin with 5 patients in the oldest age cohort in an open label
      fashion, and a review of safety, pharmacokinetic and platelet count data will be performed
      regularly. If no safety concerns are identified after 12 weeks, 18 additional patients will
      be randomised to placebo or eltrombopag (2:1 randomisation). After 7 weeks of randomized
      treatment, all patients will receive eltrombopag in an open label fashion. The total duration
      of treatment with eltrombopag will be 24 weeks. If at the time of the aforementioned 12 week
      review of the first 5 patients no safety issues are identified, dosing will begin in the next
      lower age cohort with an initial group of 5 patients. The same procedure will be followed in
      terms of safety review and subsequent enrolment and randomisation of the additional patients.
      Initiation of the younger age cohort will take place once data from the previous has been
      evaluated. Doses will be adjusted according to platelet counts and tolerability. The study
      will include a review of the safety data by a Data Safety Monitoring Board.
    


Intervention name(s): eltrombopag; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): thrombopoietin receptor agonist; placebo for comparison
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: idiopathic thrombocytopenic purpura; thrombocytopenia; pharmacodynamics; ITP; eltrombopag; pharmacokinetics; chronic ITP; pediatrics
Evaluation of Surgical Correction of Anterior Vertical Maxillary Excess (Gummy Smile) by Compression Osteogenesis.
Condition: Compression Osteogenesis
Study type: Interventional

Summary: 
      The technique of compression osteogenesis will be studied to verify its value as applied to
      manage anterior vertical maxillary excess in patients wohm are suffering from gummy smile.
    


Intervention name(s): Corticotomy followed by compression osteogenesis
Intervention type(s): Procedure
Intervention description(s): Surgical corticotomy supra apical in anterior maxilla then application of the compression osteogenesis concept via traction on miniscrews implanted above the corticotomy line
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Evaluation of Exercise Benefits to Promote Health Aging Among Chronically Ill Geriatrics in a Community
Condition: Diabetes; Hypertension; Osteoporosis; Osteoarthritis
MeSH terms: Osteoporosis; Chronic Disease
Study type: Interventional

Summary: 
      The aim of this study is to evaluate the effect of hydraulic resistance circuit training for
      elderly people with chronic illness.
    

Detailed description: 
      This study is divided into three years. The aim of the first year is to analyze the types and
      percentage of chronic illness in middle- and old-aged population in communities and the
      impact on their physical and mental function. The Second year, we will use proper exercise
      prescriptions with exercise equipment available for chronic illness population and examine
      the improvement of their physical and mental functions after exercise intervention. The third
      year, we will adopt the concept of social marketing to promote knowledge about health-related
      fitness and exercise to communities and help to establish exercise center. To chronic illness
      people, the study seeks to delay the progression of disease and disability by encouraging
      them to participate in prescribed exercises. To relatively healthy people, exercise can
      achieve the purposes of healthy aging, decreased chronic illness, and improved ADLs function
      and life quality.
    

Intervention name(s): hydraulic resistance circuit training
Intervention type(s): Device
Intervention description(s): 12 weeks (3 times per week, 40 min circuit) of hydraulic resistance circuit training that consisted of 10 types of equipments for different part of strength training.
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Health Services Research
Keywords: Aging; Chronic illness; Resistance circuit training
Effects of Oxytocin on Bleeding Outcomes During Dilation and Evacuation
Condition: Abortion; Dilation and Evacuation; Hemorrhage; Blood Loss
MeSH terms: Hemorrhage; Dilatation, Pathologic
Study type: Interventional

Summary: 
      Currently, there is very little research to identify ways to decrease blood loss during D&E
      (dilation and evacuation) procedures. The objective is to determine whether routine use of
      intravenous oxytocin will improve bleeding outcomes at the time of D&E at 18-24-weeks
      gestation. To evaluate the hypothesis, investigators will perform a randomized,
      double-blinded, placebo-controlled trial. The patient will be followed until discharged from
      the postoperative care unit during which time patient satisfaction, pain score and
      postoperative bleeding will be assessed.
    


Intervention name(s): intravenous oxytocin; Intravenous Fluids and Electrolytes
Intervention type(s): Drug; Drug
Intervention description(s): 30 units of oxytocin added to 500ml of inert IV fluid (saline, lactated ringer); 500 ml of inert IV fluid
Intervention MeSH terms: Oxytocin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Multimodal Intervention Program for Children With Attention Deficits (Child ViReal Support Program)
Condition: Attention Deficit; Attention Deficit Disorder With Hyperactivity
MeSH terms: Attention Deficit Disorder with Hyperactivity
Study type: Interventional

Summary: 
      The main aim of this study is the development and implementation of a multimodal intervention
      program consisting of parent training and child training which utilizes the potentials of
      immersive virtual reality technology (iVR) in order to test its effectiveness for children
      with attention deficits.
    

Detailed description: 
      Attention deficits are commonly observed in children and attention deficit hyperactivity
      disorder (ADHD) is one of the most commonly diagnosed childhood neurodevelopmental disorders.
      It is evidently known that attention deficits affect children's school, social and family
      life making it essential for them and their parents to receive specialized supportive
      services. Behavioral parent training (BPT) and cognitive-behavioral treatment (CBT) are
      considered evidence-based interventions for children with ADHD. In fact, they have positive
      effects on the management of children's behaviors, organization, reduction of parental stress
      and enhancement of parental self-efficacy. In addition to these traditional evidence-based
      interventions, immersive virtual reality (iVR) technology has been applied lately as part of
      intervention programs for children with attention deficits / ADHD diagnosis specifically for
      cognitive training.

      In line with the above, investigators have designed and developed a multimodal intervention
      program named Child ViReal Support program. This program is comprised of parent training and
      child training and utilizes the potentials of iVR technology. In order to assess the efficacy
      of Child ViReal Support program, the investigators will conduct a randomized controlled
      trial, which consists of a pre-training phase, a training phase, a post-training phase and a
      follow-up.
    

Intervention name(s): Behavioral Parent Training (BPT); Child Training (iVR + CBT)
Intervention type(s): Behavioral; Combination Product
Intervention description(s): The parent training consists of 8 weekly group sessions where parents are trained on behavior modification techniques, optimal parental practices as well as techniques for the enhancement of their children's cognitive deficits.; The child training program is comprised of 16 individualized weekly sessions. It utilizes the potentials of immersive virtual reality (iVR) technology for the training of focused and sustained attention and combines practices based on cognitive-behavioral approach for children's training on behavioral and emotional self-regulation skills.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: immersive virtual reality (iVR); multimodal intervention; behavioral parent training; cognitive-behavioral treatment; neurodevelopmental dysfunctions; cognitive training
Long-term Effects of Intensive Insulin Treatment in Type 1 Diabetes
Condition: Coronary Heart Disease; Stroke; Renal Failure
MeSH terms: Heart Diseases; Coronary Disease; Coronary Artery Disease; Myocardial Ischemia
Study type: Interventional

Summary: 
      To investigate long-term effects on cardiovascular mortality/morbidity and renal failure in
      type 1 diabetes patients former randomized to intensive insulin treatment
    

Detailed description: 
      The Stockholm Diabetes Intervention Study (SDIS) aimed to determine whether intensified
      insulin treatment were feasible and led to less serious diabetic complications. 102 patients
      with type 1 diabetes mellitus were randomized (October 1982 to March 1984) to intensified
      conventional treatment (ICT; n=48) or standard treatment (ST; n=54). The randomized SDIS
      study lasted for 7.5 years, whereas 96 patients were fully evaluated. Thereafter patients
      were assigned to their regular clinical visits.

      In the present interventional study we wanted to study all-cause mortality and cardiovascular
      outcomes (i.e. myocardial infarction and stroke), and renal failure in the SDIS cohort until
      december 31 2011.
    

Intervention name(s): Intensive insulin treatment; Standard insulin treatment
Intervention type(s): Drug; Drug
Intervention description(s): Mealtime insulin (Actrapid) Basal insulin (Monotard); Insulin Mixtard
Other intervention name(s): Basal-bolus insulin treatment; Mixed insulin 2-3 times per day
Intervention MeSH terms: Insulin; Insulin, Globin Zinc
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Effect of Degree of Rice-polishing on Glycaemic Response
Condition: Diabetes Mellitus; Obesity
Study type: Interventional

Summary: 
      To investigate the effects of rice polishing on glycaemic and insulinaemic response in
      healthy Chinese male volunteers.
    

Detailed description: 
      There will be a total of 8 test session. Each session will last for 3.5 hours. At each test
      session, volunteers will be served with test meal and blood will be collected. After an
      overnight fast, subjects will visit the research center. Two fasting capillary blood samples
      will be collected via fingerprick. Following the fasting samples, subject will consume the
      test meals. Further blood samples will be collected at 15, 30, 45, 60, 90, 120, 150, 180
      minutes after the ingestion of test meal. These samples will be used to analyses for whole
      capillary blood glucose. At every 30 minute interval, samples will be collected for analysis
      of capillary plasma insulin.
    

Intervention name(s): Glucose Reference 1; Glucose Reference 2; Glucose Reference 3; Brown Rice; 3 % polished rice; 6 % polished rice; 9 % polished rice; 20 % Polished rice
Intervention type(s): Other; Other; Other; Other; Other; Other; Other; Other
Intervention description(s): 50 g of glucose dissolved in 250 ml of water (First glucose control visit); 50 g of glucose dissolved in 250 ml of water (Second glucose control visit); 50 g of glucose dissolved in 250 ml of water (Third glucose control visit); Unpolished brown rice containing 50 g of available carbohydrate was cooked using a rice cooker (Toyomi) at a ratio of rice to water of 1: 2; 3% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2; 6% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2; 9 % polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2; White rice (20% polished rice), containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Randomized crossover design
Masking: None (Open Label)
Primary purpose: Other
Pharmacogenetics Study on the Effects of Anesthetic Drugs on Circulatory Function
Condition: Drug Reaction; Anesthetic; Hemodynamic Rebound; Gene
MeSH terms: Drug-Related Side Effects and Adverse Reactions
Study type: Observational

Summary: 
      This study intends to study the effects of anesthetics on Circulatory Function Genomics and
      find the anesthetic effects in pharmacodynamics, pharmacokinetics, drug receptor or target
      DNA level differences, further guiding individual treatment in clinic, promoting the
      development of precision the medicine.The anesthesia medication during perioperative period
      is more and more accurate,reasonable and safe, so as to improve the satisfaction of the
      patients and their families in the perioperative period, to ensure the safety of patients.
    

Detailed description: 
      This study is a non traumatic and non intervention study, and will use a large sample of
      clinical research, the number of subjects to be enrolled in the study group are 200 cases.
      The basic information of the study was included in the study before the operation. During the
      operation, the investigators need a collection of participants's arterial blood and monitor
      the hemodynamic index and anesthesia depth by bispectral index(BIS) . Further more，the
      investigators will follow up the participants' condition after operation.Dividing the
      patients into different groups according to their clinical features.The relationship between
      vital signs and the depth of anesthesia was analyzed and compared between different
      groups.Blood samples collected during the operation were detected by gene test. Comparing the
      results of genetic testing and clinical data analysis, then the investigators will find the
      differences in the expression of the gene polymorphisms of anesthetic drugs in the
      circulating function.
    

Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients from department of thoracic and cardiovascular surgery in Xiangya Hospital,
        Central South University
      
Biospecimen description: 
      whole blood
    
Keywords: personalized medicine; genetic polymorphism; pharmacogenetics; hemodynamic change
Randomized Controlled Trial of Health Care to Elderly Patients.
Condition: Congestive Heart Failure; Angina Pectoris; Asthma; Pneumonia; Fractures
MeSH terms: Heart Failure; Angina Pectoris
Study type: Interventional

Summary: 
      To study the efficacy of multicomponent treatment and care for patients with acute illness or
      deterioration of a chronic disease at a nursing home in primary health care compared to
      traditional treatment at hospital.
    

Detailed description: 
      Managers at St. Olavs University Hospital and the City of Trondheim local authority decided
      in 2001 to establish a reinforced department at a nursing home with a multicomponent approach
      to patient treatment.

      In the study treatment at a nursing home will be compared with conventional treatment in
      ordinary hospital beds in medical, surgical and orthopedic departments at a hospital.
      Participating doctors at the hospital together with general practitioners shall develope
      inclusion criteria through Delphi technique. Eligible participants will be hospitalized from
      their ordinary home and expected to return to home after treatment. When an eligible patient
      is identified and accepted for inclusion, randomization will be performed by the Clinical
      Research Department at the Faculty of Medicine.
    

Intervention name(s): Multicomponent treatment; usual care
Intervention type(s): Other; Other
Intervention description(s): Specialized care in preparing recharge to home; Usual recharge directly from hospital to home
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Treatment of elderly.; Nursing home.; Rehabilitation.; Readmissions.