bioihbjkbjnl/mcl2 huggingface dataset:
Text Messaging to Improve HIV Testing Among Young Women in Kenya
Condition: HIV Infection
MeSH terms: HIV Infections
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether regularly scheduled HIV sensitization text
      messages (SMS) are effective in increasing HIV testing rates among young women in Kenya.
    

Detailed description: 
      In Kenya, women have higher rates of infection (6.9%) than men (4.4%) and young women aged
      15-24 years are over three times more likely to be infected than young men of the same age
      group. HIV testing and counseling remains critical to identifying new infections and
      preventing the spread of HIV but many young women do not test and still continue to engage in
      high risk behavior.

      HIV programs have begun to leverage mobile phones and text messages to increase the reach and
      scale of interventions. Kenya currently has 32.2 million mobile phone subscribers,
      representing a 79.2% country penetration. Text messages have been used successfully in Kenya
      for marketing purposes and have even been demonstrated to increase antiretroviral (ART)
      adherence. Despite advances in mobile-based applications to improve issues in health, none of
      these health applications have yet been able to reach the scale of mobile phone-based
      financial products in Kenya.

      Given the potential synergies of text message use and need for HIV testing, a randomized
      quasi-experimental study was conducted to test whether weekly text messages encouraging HIV
      testing and improving HIV awareness would increase HIV testing, enhance HIV risk perception
      and reduce high risk behaviour among young women 18-24 years old in a predominantly rural
      region in Kenya.

      Women in the intervention arm received access to a suite of HIV sensitization text messages
      sent weekly to increase their awareness of HIV and encourage them to test with the option of
      texting back for more information to a maximum of three times per week. Women in the control
      arm did not receive these messages. All women were followed up for six months with monthly
      SMS surveys collecting data on their HIV testing practices, sexual behaviour and risk
      perception.
    

Intervention name(s): Weekly HIV sensitization text messages
Intervention type(s): Behavioral
Intervention description(s): Weekly HIV sensitization text messages with option to text back up to 3 times per week for additional messages. Message topics included pregnancy, condoms, sexually transmitted infections, contraceptives, anal sex and personal risk of HIV. All messages ended with the phrase "Get tested for HIV".
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: SMS; Text messages; Young women; HIV
A WrapAround Case Management Program for Youth Injured by Violence
Condition: Intentional Injury
Study type: Interventional

Summary: 
      This is a feasibility study of a WrapAround Case Management Program for Youth Injured by
      Violence. Youth (aged 10-24) who have been injured by violence and visit the emergency
      department will be offered a support worker who will provide WrapAround Case Management. This
      study is designed to assess the feasibility of recruitment, enrollment and follow-up.
    


Intervention name(s): WrapAround Case Management
Intervention type(s): Behavioral
Intervention description(s): Youth Injured by Violence will be paired with a support worker who has extensive experience working with youth affected by violence.It is important to note that the wraparound concept involves individualized care planning and management. As such, the specific care plan will be different for each participant. Through early intensive meetings, they will develop a mentoring relationship. They will work with the youth to develop a support team, which may include family, teachers, child welfare workers and truly anyone the youth has decided can help them in their path to making positive choices.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: youth; violence; injury; emergency department; intervention
Physical Therapy Treatment on Children and Adolescents With Neurological Pathologies
Condition: Neurologic Disorder; Duchenne; Pediatric Disorder; Sensorimotor Disorder Nos
MeSH terms: Muscular Dystrophy, Duchenne; Nervous System Diseases
Study type: Interventional

Summary: 
      To evaluate the positive effects of a home-based physical therapy intervention added to the
      usual physical therapy programs performed in children with neurological pathologies that
      induce sensorimotor impairments that affect their quality of life and the importance of the
      implications of their families in their treatment.
    


Intervention name(s): Home-based physiotherapy; Usual Physiotherapy
Intervention type(s): Other; Other
Intervention description(s): Manual Therapy, passive and active mobilizations, stretching, respiratory techniques; Usual care provided for the management of neurological disorders in children
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Childhood; Neurologic disorder; Duchenne
Effects of Ketamine on Mentalizing and Metacognition in Healthy Volunteers
Condition: Ketamine-Induced Psychotic Disorder; Social Cognition; Theory of Mind
MeSH terms: Psychotic Disorders; Shared Paranoid Disorder
Study type: Interventional
Phase: Phase 4

Summary: 
      Antipsychotic medication shows generally good effect sizes when looking at reduction of
      positive psychotic symptoms of schizophrenia, such as paranoia or delusion. However, social
      functioning often remains deficient in patients, meaning dopamine-receptor antagonists are
      not sufficient in treatment of people with schizophrenia.

      A naturalistic video-based paradigm, named MASC has been used in the past to model over- and
      undermentalizing in patients with autism spectrum disorder and schizophrenia, since deficits
      in mentalizing can be explained by either overinterpreting a social situation (e.g. paranoid
      thoughts about intentions of others towards self) or by lacking the skill to read intentions
      of others.

      To find out whether experimental manipulation via a non-competetive N-methyl-D-aspartate
      antagonist can induce difficulties with social cognition similar to those observed in people
      with schizophrenia, the investigators will conduct a RCT applying either ketamine or a
      placebo intravenously while participants are completing the above mentioned mentalizing task
      in the fMRI-scanner.
    


Intervention name(s): Ketamine; Nacl 0.9%
Intervention type(s): Drug; Drug
Intervention description(s): Ketamine is applied with a Graseby 3500 intravenous infusion pump controlled by the STANPUMP software (Steven Shafer, M.D., Anesthesiology Service, PAVAMC 3801 Miranda Ave., Palo Alto, USA). Target plasma levels are 100 ng/ml with an initial bolus administered as a 2 mg/ml solution.; Saline solution will also be applied with the Graseby 3500 intravenous infusion pump controlled by the STANPUMP software (Steven Shafer, M.D., Anesthesiology Service, PAVAMC 3801 Miranda Ave., Palo Alto, USA).
Intervention MeSH terms: Ketamine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: ketamine; fMRI; psychosis; mentalizing; social cognition; metacognition
Investigating Inter-individual Variability in Glycemic and Insulin Responses
Condition: Hyperglycemia; Insulin Sensitivity
MeSH terms: Insulin Resistance; Hyperglycemia
Study type: Interventional

Summary: 
      This study aims to test the following hypothesis in healthy lean young men:

        -  There are differences in glycemic response (GR) and insulin response (IR) between
           Chinese, Malay and Asian-Indian

        -  There are differences in GI values to the same food between ethnic groups

        -  There are ethnic differences postprandial GR and IR for high vs low GI foods

        -  Mastication, salivary amylase activity, gastric emptying rate and gut microbiota
           composition influences inter-individual glycemic and insulinemic variability

        -  Ethnic differences in mastication, salivary amylase activity, gastric emptying rate and
           gut microbiota composition determines the inter-ethnic glycemic and insulinemic
           variability
    

Detailed description: 
      There is extensive evidence that numerous biological digestive factors varies between
      individuals and influence postprandial glycemic response (GR) and insulin response (IR),
      which are well established risk factors that precipitate the development of Type 2 diabetes
      mellitus (T2DM). However, no study to date has measured and compared physiological parameters
      such as mastication, salivary amylase activity, gastric emptying rates and gut microbiota in
      a multi-ethnic Asian population, with varying prevalence of obesity and T2DM. The aim of this
      study is to investigate ethnic differences in GR and IR as well as the GI values of foods.
      Additionally, we aim to examine how physiological digestive factors contribute to
      inter-ethnic and inter-individual variability in GR and IR. The study outcomes can
      potentially explain, in part, the varying susceptibility to obesity, T2DM and DM control
      between Chinese, Malays and Asian-Indians in Singapore, as reflected by the differences in
      prevalence of obesity, T2DM and DM control among the three local ethnic groups.
    

Intervention name(s): Jasmine rice; Parboiled basmati rice
Intervention type(s): Other; Other
Intervention description(s): Standardised rice:cooking liquid ratio for 50g available carbohydrate portion; Standardised rice:cooking liquid for 50g available carbohydrate portion
Other intervention name(s): Dreamrice
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Ethnic differences; Inter-individual variability; Glycemic response; Insulin response; Mastication; Salivary alpha-amylase; Gastric emptying; Metagenome
Clinical Trial Comparing Three Anterior Cruciate Ligament Reconstructive Procedures
Condition: Knee Injuries
MeSH terms: Knee Injuries
Study type: Interventional

Summary: 
      The objective of this prospective study is to assess the clinical, functional and
      radiological outcomes of three different ACL reconstruction procedures: Bone Patella Bone
      graft, Single bundle hamstring graft and anatomical Double bundle graft in terms of pain,
      swelling, mobility, quadriceps girth size, stability, proprioception, bone mineral density
      and functional status.
    

Detailed description: 
      Anterior cruciate ligament (ACL) reconstruction surgery is one of the common procedures
      performed by orthopedic surgeons with approximately 100,000 cases performed per year in the
      United States. A large amount of sports injuries were related to ACL problem. As such, ACL
      injuries and treatment is still widely under intensive study.

      Traditionally, ACL surgery has been focused on using bone patella bone graft and single
      bundle hamstring graft. Problems of knee pain, unstable fixation, rotational instability and
      degenerative changes were reported. Recently, the use of double bundle hamstring graft to
      reconstruct the ACL according its anatomy aiming to improve the rotational stability was
      proposed. However, results about the clinical, functional and radiological outcomes are
      limited.

      The objective of this prospective pilot study is to assess the clinical, functional and
      radiological outcomes of three different ACL reconstruction procedures: Bone Patella Bone
      graft, Single bundle hamstring graft and anatomical Double bundle graft in terms of pain,
      swelling, mobility, quadriceps girth size, stability, proprioception, skin sensation, bone
      mineral density and functional status.

      Subjects to be operated for ACL reconstruction and meeting the inclusion and exclusion
      criteria will be recruited. Subjects will be randomly assigned to the three surgical groups
      by block randomization. Demographic information, parameters in recovery domain, functional
      domain and stability domain, isokinetic test, motion analysis domain, proprioception and
      radiographical measurements will be made at baseline and at day 1, week 2, week 4, week 8,
      month 3, month 5, 1 year and 2 years post-surgery. The effect of different surgical
      techniques and time on the different outcomes will be analysed by 2-way ANOVA.
    

Intervention name(s): Single bundle hamstring; Double bundle hamstring; Bone patellar tendon bone
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): Single bundle hamstring; Double bundle hamstring; Bone patellar tendon bone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Anterior cruciate ligament rupture; Anterior cruciate ligament(A02.513.514.100)
Relative Bioavailability Study to Compare Inhalation of Terbutaline Sulphate 1,5mg Via Turbuhaler M3 With Turbuhaler M2
Condition: Healthy Volunteers
MeSH terms: Respiratory Aspiration
Study type: Interventional
Phase: Phase 1

Summary: 
      Relative bioavailability study to compare inhalation of Terbutaline Sulphate 1,5mg via
      current version of Turbuhaler with inhalation via a new version
    

Detailed description: 
      An Open-label, Single-dose, 2-period Cross over Study in Healthy Male and Female Volunteers
      to Assess Relative Bioavailability of Terbutaline Sulphate 1.5 mg after Inhalation via the M3
      Turbuhaler (New Version) Compared with the M2 Turbuhaler (Current Version)
    

Intervention name(s): terbutaline sulphate delivered dose; terbutaline sulphate metered dose
Intervention type(s): Drug; Drug
Intervention description(s): 0.4 mg terbutaline sulphate (delivered dose) per inhalation; 0.5 mg terbutaline sulphate (metered dose) per inhalation
Other intervention name(s): Turbuhaler New Version; Turbuhaler Current Version
Intervention MeSH terms: Terbutaline
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Healthy volunteers, pharmacokinetic, inhalation
Phase II Double Blind Placebo Controlled Trial of Risperidone in Tourette Syndrome
Condition: Tourette Syndrome
MeSH terms: Tourette Syndrome; Syndrome
Study type: Interventional
Phase: Phase 2

Summary: 
      OBJECTIVES: I. Conduct a randomized, double blind, placebo controlled, parallel study of the
      atypical neuroleptic risperidone (RIS) in the treatment of children and adults with moderate
      to severe Tourette Syndrome.

      II. Evaluate further the safety of RIS in this population.
    

Detailed description: 
      PROTOCOL OUTLINE: This is a randomized, double blind, placebo controlled study. Initially,
      all patients receive placebo capsules twice daily in a single blind fashion during the first
      2 weeks of study.

      Then, patients are randomized to receive either risperidone (RIS) or placebo for 8 weeks. The
      dose of RIS is increased weekly over the first 4 weeks of treatment, as tolerated.

      Patients continue RIS for 4 additional weeks at the dose prescribed during week 4.

      All patients receive diagnostic evaluations at the beginning and end of the 2 week initial
      single blind phase, and at the end of weeks 2, 4, 6, and 8 of the active treatment phase.
    

Intervention name(s): risperidone
Intervention type(s): Drug
Intervention MeSH terms: Risperidone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Tourette syndrome; neurologic and psychiatric disorders; rare disease
L-methylfolate Supplementation to OROS-Methylphenidate Pharmacotherapy in ADHD Adults
Condition: Attention Deficit Hyperactivity Disorder
MeSH terms: Hyperkinesis; Attention Deficit Disorder with Hyperactivity
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      This pilot study seeks to evaluate initial evidence for the effect of L-methylfolate
      supplementation to OROS-Methylphenidate pharmacotherapy on ADHD symptoms and associated
      features in adults with ADHD, as well as tolerability of this supplementation. The
      investigators will conduct a 12-week double-blind randomized placebo-controlled trial with
      L-methylfolate supplementing open-label OROS-Methylphenidate (OROS-MPH). The investigators
      propose to examine 40 adult (ages 18-55) subjects satisfying the DSM-IV diagnostic criteria
      for ADHD.
    


Intervention name(s): L-methylfolate; OROS-Methylphenidate; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 15mg/day L-methylfolate.; All subjects will be treated with open-label OROS-MPH; 15 mg matched placebo comparator, with open-label OROS-Methylphenidate
Other intervention name(s): Deplin®; Concerta®
Intervention MeSH terms: Methylphenidate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: ADHD; Attention Deficit Hyperactivity Disorder; Deplin; L-methylfolate; Natural Treatments; Medical Food
Sevoflurane Induced Emergence Agitation
Condition: Emergence Agitation
MeSH terms: Psychomotor Agitation; Emergence Delirium
Study type: Interventional
Phase: Phase 4

Summary: 
      Investigators evaluated the effect of intranasal ketamine or alfentanil addition to oral
      midazolam for prevention of emergence agitation.Seventy-eight, 1-8 year-old children,
      undergoing urological surgery with sevoflurane anesthesia was included in the study. All the
      children received oral midazolam 0.5 mg/kg 40 minutes before anesthesia induction then
      enrolled to one of the study groups, randomly. Ketamine group (Group MK; n=26) patients were
      given 2mg/kg intranasal ketamine whereas, alfentanil group (Group MA; n=25) were given
      10microgram/kg intranasal alfentanil 8-10 min before the induction of anesthesia. Saline
      group (Group MS; n=27) received intranasal isotonic saline.Parental separation, mask
      acceptance were evaluated with a 4- point scale. Emergence agitation was evaluated with
      Pediatric Anesthesia Emergence Delirium score.
    


Intervention name(s): midazolam; alfentanil; ketamine
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Group M; Group MA; Group MK
Intervention MeSH terms: Midazolam; Ketamine; Alfentanil
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Child; Sevoflurane; Emergence delirium; General anesthesia; Premedication.
Simultaneous Integrated Boost Radiotherapy and Concurrent Chemotherapy for Locally Advanced Esophageal Carcinoma
Condition: Esophageal Neoplasms
MeSH terms: Esophageal Neoplasms
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This phase Ⅰ/Ⅱ trial is designed to explore a higher radiation dose by using IMRT
      simultaneous integrated boost technique with or without concurrent chemotherapy for locally
      advanced esophageal carcinoma.
    

Detailed description: 
      Despite the application of IMRT and the studies of concurrent chemoradiation in esophageal
      carcinoma, which improves 5-year survival rate from 10% to 20%-40% and decrease recurrence
      rate from 80% to 50%-60%, local recurrence remains to be the most common failure pattern.
      Therefore, enhancing local control is the key to obtain a better survival.

      A phase Ⅱ study of radical radiotherapy with IMRT simultaneous integrated boost technique and
      concurrent chemotherapy for esophageal carcinoma use the same radiation dose as the high dose
      arm in RTOG 94-05, which reveals an significantly improved median survival time of 23 months
      and 3-year overall survival rate of 44.4%. This study implies the simultaneous integrated
      boost technique may be effective to some extent. But the question is how to identify patients
      who may gain potential benefits, and whether this therapeutic model can be copied in the
      specific situation in China? Few adverse effects such as perforation, hemorrhage and stenosis
      was reported, mainly owing to the lack of cases. For widely application of this new technique
      in the clinic, more studies need to be conducted in the future to obtain sufficient evidence.

      The current IMRT can simultaneously achieve prophylactic dose (DT 50Gy) and radical dose (DT
      60-64Gy) in respective target volume by using inverse intensity-modulated planning system.
      However, it is still controversial on whether esophageal carcinoma can receive prescription
      dose more than 2.0Gy each time. That is to say, it is challengeable to find an optimal
      fraction dose and total dose between tumor and adverse effects. For this reason, the dose
      escalation trial is to be conducted to explore the clinical value and optimal dose to
      esophageal carcinoma with different radiosensitivity, and also provide data support for phase
      Ⅲ clinical trials.
    

Intervention name(s): IMRT simultaneous integrated boost; Paclitaxel; Nedaplatin; Esophagectomy
Intervention type(s): Radiation; Drug; Drug; Procedure
Intervention description(s): To achieve a prophylactic dosage and radical dosage once respectively; Paclitaxel from 45 to 60 mg/m2 per week concurrent with radiotherapy for 5weeks; Nedaplatin 25mg/m2 per week concurrent with radiotherapy for 5weeks; Radical esophagectomy 4-6 weeks after neoadjuvant therapy
Other intervention name(s): Taxel
Intervention MeSH terms: Paclitaxel; Nedaplatin
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment