bioihbjkbjnl/mcl2 huggingface dataset:
The Effect of Online Peer and Adult Education Given to Adolescents With Allergic Asthma
Condition: Self Efficacy; Asthma; Asthma in Children
MeSH terms: Asthma
Study type: Interventional

Summary: 
      Objectives: To examine the effect of interactive online education given by peers or adults on
      anxiety, self-efficacy, quality of life, and disease knowledge and management in adolescents
      with allergic asthma in the 10-14 age group.

      Methods: The research was conducted as a randomized controlled study. The study sample
      consisted of 84 adolescents divided into experimental groups [receiving peer(n=28) or
      adult(n=28) education] and control(n=28) group. The adolescents in the peer or adults were
      given online interactive education concerning allergic asthma and the management thereof. The
      control group received only usual training.Data were collected using an Adolescent Personal
      Data Form, the State Anxiety Inventory for Children, the Self-Efficacy Scale for Children and
      Adolescents with Asthma, the Pediatric Asthma Quality of Life Questionnaire, and the Disease
      Knowledge and Management Questionnaire. Data were collected from the adolescents before (T0)
      and immediately after education (T1), and after one (T2) and three months (T3).

      This study is a non-blinded randomized controlled trial. . All screened adolescents with
      asthma were randomly assigned to one of the three groups: the peer or adults education groups
      that received a 6 weeks asthma education and a control group that received usual care. The
      three groups were then followed prospectively immediately, 1, and 3 months after training to
      evaluate the effectiveness of training compared with usual care.
    


Intervention name(s): education
Intervention type(s): Other
Intervention description(s): Comparison of the effectiveness of peer or adult education to adolescents with asthma
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: In this study, there is an intervention and a control group.
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Adolescent; Anxiety; Asthma; Knowledge; Self-efficacy; Quality of life
A Study Comparing the Efficacy and Safety of Ziprasidone and Aripiprazole for the Treatment fo Schizophrenia or Schizoaffective Disorder in Hospitalized Patients
Condition: Schizophrenia
MeSH terms: Schizophrenia; Psychotic Disorders
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to compare the efficacy and safety of ziprasidone and
      aripiprazole in hospitalized patients with schizophrenia or schizoaffective disorder
    


Intervention name(s): Aripiprazole; Ziprasidone
Intervention type(s): Drug; Drug
Intervention description(s): Oral aripiprazole capsules 15 mg once daily from Days 1-14; thereafter, doses could be adjusted on Days 14 and 21 to 10, 15, or 30 mg once daily; patients treated for 28 days; Oral ziprasidone capsules 40 mg twice daily on Day 1, 60 mg twice daily on Day 2, 80 mg twice daily on Days 3-14; thereafter, doses could be adjusted on Days 14 and 21 to 40, 60, or 80 mg twice daily; patients treated for 28 days
Intervention MeSH terms: Aripiprazole; Ziprasidone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Consumption Status of Caffeine and Adverse Effects Experience Among Anesthetists
Condition: Caffeine; Caffeine Withdrawal; Caffeine Dependence
Study type: Observational

Summary: 
      High-caffeine consumption has been increasing in physicians, frequently causing the most
      common symptoms such as tremor, insomnia, anxiety, and nervousness and rarely leading to
      serious adverse effects like seizure, acute mania, and stroke due to caffeine overdose. There
      have been no studies regarding analysis of high-caffeine consumption and its adverse effects
      among anesthetists.
    

Detailed description: 
      This study was to examine high-caffeine consumption patterns, associated factors, and adverse
      effects based on responses anesthetists with different age of experience.
    

Intervention name(s): Survey
Intervention type(s): Other
Intervention description(s): Prevalence of safe caffeine consumption among anesthetists
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Almost all anesthetists who approved to continue the survey.
Opioid Growth Factor in Treating Patients With Advanced Pancreatic Cancer That Cannot Be Removed By Surgery
Condition: Pancreatic Cancer
MeSH terms: Pancreatic Neoplasms
Study type: Interventional
Phase: Phase 2

Summary: 
      RATIONALE: Opioid growth factor may stop the growth of pancreatic cancer by blocking blood
      flow to the tumor.

      PURPOSE: This phase II trial is studying how well opioid growth factor works in treating
      patients with advanced pancreatic cancer that cannot be removed by surgery.
    

Detailed description: 
      OBJECTIVES:

      Primary

        -  Determine the growth inhibitory effects of opioid growth factor ([Met^5]-enkephalin) in
           patients with advanced unresectable pancreatic cancer.

      Secondary

        -  Determine the pharmacokinetics of this drug in these patients.

        -  Determine the quality of life of patients treated with this drug.

        -  Determine the pain control, depression, and nutritional status of patients treated with
           this drug.

      OUTLINE: This is an open-label study.

      Patients receive opioid growth factor ([Met^5]-enkephalin) IV over 45 minutes once weekly.
      Treatment continues in the absence of disease progression or unacceptable toxicity.

      Quality of life is assessed at baseline, every 4 weeks during study treatment, and at the
      completion of study treatment.

      Patients are followed weekly for survival.

      PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.
    

Intervention name(s): opioid growth factor; metenkephalin, OGF-opioid growth factor
Intervention type(s): Biological; Biological
Intervention description(s): OGF was administered in saline at 250 ug/kg intravenously over 45 minutes; OGF given in saline iv 250 ug/kg weekly
Other intervention name(s): Opioid growth factor or OGF is a 5 amino acid peptide; opioid growth factor
Intervention MeSH terms: Analgesics, Opioid; Mitogens; Enkephalin, Methionine
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: recurrent pancreatic cancer; stage III pancreatic cancer; stage IV pancreatic cancer
Personal Protective Equipment Comfort and User Attitude During COVID-19
Condition: Covid19; Student; Physiotherapy
MeSH terms: COVID-19
Study type: Observational

Summary: 
      There are studies in the literature that evaluate the attitude, behavior and comfort level of
      students who do internships in different disciplines (medicine, pharmacy) towards the use of
      protective equipment. However, no study evaluating physiotherapy and rehabilitation students
      was found. Therefore, the present study aims to investigate the behaviors and attitudes
      regarding the use of personal protective equipment of physiotherapy and rehabilitation
      department students who are interning in the Covid-19 pandemic.
    

Detailed description: 
      A total of 250 participants, who are physiotherapy and rehabilitation intern students in
      Turkey, will be included in the present study. Data collection will be carried out using an
      online survey. The online survey link will be shared via social media accounts and via mail.
      The questionnaire created through Google forms will be delivered to the participants via the
      link. The link will be active in the data collection process. Before the participants start
      the questionnaire, they will be asked whether they were willing to participate. The
      socio-demographic characteristics (age, gender, weight, height) and health status (presence
      of chronic disease and drugs used) will be questioned. In addition, the information about the
      institution where the internship was held and the duration of the internship, internship
      hours, time spent at the internship will be collected. Personal Protective Equipment Comfort
      and User Attitude Evaluation Form will be used to evaluate participant's thoughts, attitudes
      and behaviors towards the use of personal equipment also physical complaints, comfort level
      due to personal protective equipment.
    

Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Physical Therapy Students
Clinical Evaluation of BW430C in Epilepsy
Condition: Epilepsy
MeSH terms: Epilepsy
Study type: Interventional
Phase: Phase 3

Summary: 
      To evaluate safety information of BW430C when administered using the lower starting doses and
      slower dose escalations as recommended Global Data Sheet
    


Intervention name(s): lamictal
Intervention type(s): Drug
Intervention description(s): anti-epileptic drug
Intervention MeSH terms: Lamotrigine
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: epilepsy; Incidence of rash; safety evaluation for initial dose; patients with Valproic acid
Study to Investigate the Safety and Efficacy of BRII-835 and BRII-179 Combination Therapy Treating Chronic HBV Infection
Condition: Hepatitis B, Chronic
MeSH terms: Hepatitis A; Hepatitis B; Hepatitis B, Chronic; Hepatitis
Study type: Interventional
Phase: Phase 2

Summary: 
      This is an open label, randomized, parallel-group study to evaluate the safety and efficacy
      of combination treatment BRII-835 (VIR-2218) and BRII-179 (VBI-2601) in adult participants
      with chronic HBV infection
    


Intervention name(s): BRII-835 (VIR-2218); BRII-179 (VBI-2601) with IFN-α; BRII-179 (VBI-2601)
Intervention type(s): Drug; Biological; Biological
Intervention description(s): BRII-835 (VIR-2218) will be given by subcutaneous injection; BRII-179 (VBI-2601) with IFN-α will be co-administered by intramuscular injection; BRII-179 (VBI-2601) will be administered by intramuscular injection
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Hepatitis B Virus; Chronic Hepatitis B; HBV; Hepatitis
Post-operative Thoracic Epidural Analgesia and Incidence of Major Complications: a Large Retrospective Dual Center Experi-ence
Condition: Neuropathic Pain; Chronic Pain; Thoracic Cancer
MeSH terms: Neuralgia; Chronic Pain
Study type: Observational

Summary: 
      A retrospective observational dual center study investigating side effects and major
      complications after thoracic epidural insertion according to local safety protocols.
    

Detailed description: 
      Abstract: (1) Background: Thoracic epidural analgesia is considered the gold standard in
      post-operative pain management following thoracic surgery. This study was designed to explore
      the safety of thoracic epidural analgesia and to quantify the incidence of its post-operative
      side-effects in patients undergoing thoracotomy for major surgery, such as resection of lung
      malignancies and lung transplantation. (2) Methods: This is a retrospective, dual-center
      observa-tional study implementing patients that underwent major thoracic surgery including
      lung trans-plantation and received concurrent placement of thoracic epidural catheters for
      postoperative an-algesia. An electronic system of referral and documentation of complications
      was used, and information was retrieved from our electronic critical care charting system.
      Side effects such as nausea and vomiting , itching, catheter related issues and also major
      complications such as epidural haematoma, abscess, or permanent nerve damage were
      investigated.

      The study aims to highlight the importance of a solid documentation and recording system
      alongside with the implementation of safety protocols.
    

Intervention name(s): thoracic epidural insertion
Intervention type(s): Procedure
Intervention description(s): thoracic epidural for pain relief after major thoracic surgery and lung transplantation
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Patients underwent major thoracic surgery and lung transplantation. ASA status 1-3
Dietary Arachidonic Acid, Obesity and Atopic Respiratory Disease
Condition: Allergy; Obesity
MeSH terms: Respiratory Tract Diseases; Respiration Disorders; Obesity
Study type: Observational

Summary: 
      Epidemiological studies have shown obesity to be a risk factor of asthma. Research evidence
      of obesity and atopic(ie. allergic)-related respiratory diseases, has been less clear. The
      purpose of the present study was to test the hypothesis that the relationship between obesity
      and atopic-related respiratory disease in premenopausal women is mediated by a dietary
      imbalance of omega 6 and 3 polyunsaturated fatty acids.
    

Detailed description: 
      Sixty young adult obese and non obese women, with, and without asthma, were studied using a
      cross-sectional design. Body composition was measured by plethysmography. A fasted blood
      sample was taken to measure: specific and total immunoglobulin (IgE) antibodies,biochemical
      markers of atopy; glucose and insulin to measure insulin sensitivity; estrogen(17β-estradiol)
      and sex hormone-binding globulin to measure estrogen status of the women; hormone-products of
      fat tissue ( leptin, adiponectin, resistin, tumor necrosis factor alpha (TNFα), interleukins
      (IL-6,IL-18), that have been associated with both obesity and immune processes involved in
      asthma and allergy. Dietary intake of omega 6: linoleic acid (LA), arachidonic acid(AA); and
      omega 3 fatty acids: α linolenic (ALA), eicosapentanoic (EPA) and docosahexanoic (DHA) and
      other nutrients were assessed by food frequency questionnaire.
    

Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Female subjects were recruited from the University and surrounding local communities, using
        posted flyers, website announcements, personal announcements in classes, referrals from
        local physicians, and word of mouth. Prospective subjects were interviewed initially by
        telephone.
      
Biospecimen description: 
      plasma samples
    
Keywords: arachidonic aci; adiposity; atopy
AnakInRa for Treatment of Recurrent Idiopathic Pericarditis (AIRTRIP)
Condition: Idiopathic Recurrent Pericarditis
MeSH terms: Pericarditis; Recurrence
Study type: Interventional
Phase: Phase 4

Summary: 
      Recent findings suggest that recurrent pericarditis (RP) may be a previously unrecognized
      autoinflammatory disease. The pivotal pathogenic role of interleukin (IL)-1 in RP has been
      shown by the achievement of complete responses after treatment with the recombinant
      IL-1-receptor antagonist, anakinra. Anakinra is the recombinant form of IL-1Ra. The proposed
      study is designed to demonstarate the efficacy of anakinra in RP.
    

Detailed description: 
      This is a 8-month, multicenter (3 Italian centers), randomized, double-blind,
      placebo-controlled, multicenter, medication-withdrawal study to evaluate the efficacy,
      tolerability, and safety of anakinra in adults and children with idiopathic recurrent
      pericarditis (RP).
    

Intervention name(s): Anakinra; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 2mg/Kg daily sc up to 100mgday as maximum dose; Placebo
Intervention MeSH terms: Interleukin 1 Receptor Antagonist Protein
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: pericarditis; recurrent pericarditis; corticosteroids; anakinra
Pathogenic Species and Genotypes of Bacterial Diversity in Relation to the Severity of Dental Caries
Condition: Dental Cavity
MeSH terms: Dental Caries
Study type: Observational

Summary: 
      The primary objective of this study is to estimate the distribution of pathogenic species and
      genotypes of bacterial diversity in 7 stages ICDAS (International Caries Detection and
      Assessment System) corresponding to the severity of dental caries among patients aged 3-45
      years consulting in the Dentistry Departments of the Nîmes University Hospital and the
      Montpellier University Hospital.
    

Detailed description: 
      Secondary objectives include:

        -  Compare the distribution of bacterial species in relation to stages of severity of
           caries

        -  Compare the results from plaque with those of saliva samples.
    

Intervention name(s): Dental cavity evaluation; Saliva sampling; Plaque sampling
Intervention type(s): Other; Biological; Biological
Intervention description(s): The dental cavities present will be evaluated using the ICDAS (International Caries Detection and Assessment System).; A saliva sample will be harvested.; Plaque samples from a healthy tooth and a tooth with a cavity will be harvested.
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Volunteers aged 3 to 45 who come in to the hospital for a dental consultation.

        Patients are recruted according to age in order to form two groups: 1/2 of participants
        will be between 3 and 16 years of age; the other half of participants will be between 17
        and 45 years of age.
      
Biospecimen description: 
      Plaque and saliva samples; DNA analysis is aimed at describing microbial communities.
    
Keywords: Bacteria; microbial community; hygiene
Potato Consumption and Energy Balance
Condition: Obesity
Study type: Interventional

Summary: 
      A randomized, clinical trial will be performed to assess changes in body weight and fat mass
      with daily potato consumption versus a calorie-matched snack of almonds.
    

Detailed description: 
      This is a 30-day randomized, controlled trial with 3 arms: 1) non-potato food (almonds), 2)
      standard white potato French fry, 3) standard white potato French fry with potential
      glycemia-modulating spice/seasoning mix added.

      Free-living study participants will be assigned to consume one of the 3 foods (calorie
      matched) each day for a 30-day period. Body composition (via dual energy x-ray
      absorptiometry; DXA), and blood chemistry will be assayed at baseline and study completion,
      along with a sub-sample of subjects participating in a meal-based tolerance tests at study
      completion.
    

Intervention name(s): White potato (french fries); White potato (French fries), +seasoning; Almond
Intervention type(s): Other; Other; Other
Intervention description(s): If randomized to this group, participants will be asked to consume 1 serving of French fries (~300 kcal) each day for 30 days as a part of their usual dietary intake. French fries will be portioned and provided to participants.; If randomized to this group, participants will be asked to consume 1 serving of French fries (~300 kcal) with added potential glycemia modifying seasoning mix each day for 30 days as a part of their usual dietary intake. French fries and seasoning will be portioned and provided to participants.; If randomized to this group, participants will be asked to consume 1 serving of almonds that is calorically-matched to the French fries (~300 kcal) serving in the other arms each day for 30 days as a part of their usual dietary intake. Almonds will be portioned and provided to participants.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Basic Science
Keywords: nutrition intervention; potato consumption; energy balance
Understanding and Diagnosing Allergic Disease in Twins
Condition: Allergies
MeSH terms: Diseases in Twins
Study type: Observational

Summary: 
      The purpose of this study is to gain better understanding of how the immune system works in
      twins with and without allergic disease. Healthy volunteers are not specifically targeted.
      Healthy non-allergic study participants may be found through the course of evaluation for the
      presence of allergies.
    

Detailed description: 
      The purpose of this study is to study the genetic control and gain better understanding of
      how the immune system works in twins with and without allergic disease. Although healthy
      volunteers are not specifically targeted, they might be identified when non-allergic study
      participants are found through the course of evaluation for the presence of allergies.
    

Intervention name(s): No Intervention
Intervention type(s): Other
Intervention description(s): This study does not involve any intervention other than obtaining blood, nasal/cheek/throat/skin swabs, saliva, sputum, urine, and stool samples, breathing and skin tests.
Observational model: Other
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        Healthy volunteers are not specifically targeted. Healthy non-allergic study participants
        may be found through the course of evaluation for the presence of allergies. Women,
        minorities or children will not be excluded from this study.
      
Biospecimen description: 
      Blood, nasal /cheek/throat/skin swab, saliva, urine, stool, sputum
Probiotic Intervention for Stress and Cognition
Condition: Stress; Cognition
Study type: Interventional

Summary: 
      The effect of probiotics on stress and cognitive function in healthy adults with moderate
      stress
    


Intervention name(s): Probiotics; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Capsule; Capsule
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Gut-brain axis; Probiotics