Combined Physical-cognitive Exercise and Dietary Intervention for Postmenopausal Obese Women
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional

Summary: 
      This study aims to examine the effects of dietary intervention combined with
      physical-cognitive exergaming on cognitive performance and circulating biomarkers of obese
      postmenopausal women. It is hypothesized that participants will demonstrate significant
      improvement in cognitive performance and circulating biomarkers after participating in this
      combined program compared to baseline and the dietary and control groups.
    

Detailed description: 
      An association between obesity and cognitive impairment has been consistently reported. The
      risk of having dementia in later life is about 74% higher for middle-aged obese individuals
      than those with normal BMI. Estrogen deprivation has also been found to impair cognition.
      Thus, obese postmenopausal women are likely to be at risk of having cognitive impairment. The
      common recommendation for obesity management is dietary and exercise intervention. Research
      evidence has demonstrated that either dietary intervention or moderate-vigorous intensity
      exercise enhance cognitive function in obese adults. This study aims to examine the effects
      of 12-week home-based dietary intervention combined with physical-cognitive exergaming on
      cognitive performance and circulating biomarkers of obese postmenopausal women through a
      randomised controlled trial. Participants will be randomly assigned to one of the four
      groups: 1) dietary intervention 2) combined physical-cognitive exergaming, 3) dietary
      intervention combined with physical-cognitive exergaming, and 4) control group. Outcome
      measures including cognitive performance (i.e. executive function, episodic memory,
      attention, language, and global cognition), circulating biomarkers (i.e. BDNF level,
      metabolic parameters, inflammation markers, and adiponectin levels) as well as physical
      performance will be determined at baseline and after 12-week intervention. Findings from this
      study may offer a feasible and effective intervention program to improve cognitive
      performance along with its responsible circulating biomarkers in obese postmenopausal women.
    

Intervention name(s): Dietary intervention combined with physical-cognitive exergaming; Dietary intervention; Physical-cognitive intervention
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Intermittent Fasting (IF) [self-selected diet with 25-75% of estimated baseline energy requirements for 2 days/week (fast day) along with ad libitum for 5 days/week (feed day)] combined with physical-cognitive exercise [60-70% of heart rate maximum for aerobic and 60-70% of 1 repetition maximum, 8-12 repetitions/set, 3 sets of each exercise for resistance exercise; memory, attention, and executive function for cognition], 60 minutes per session, 3 sessions per week for 12 weeks (36 sessions)].; Intermittent Fasting (IF) [self-selected diet with 25-75% of estimated baseline energy requirements for 2 days/week (fast day) along with ad libitum for 5 days/week (feed day)].; Physical-cognitive exercise [60-70% of heart rate maximum for aerobic and 60-70% of 1 repetition maximum, 8-12 repetitions/set, 3 sets of each exercise for resistance exercise; memory, attention, and executive function for cognition], 60 minutes per session, 3 sessions per week for 12 weeks (36 sessions)].
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Other
Keywords: Dietary intervention; Cognitive function; Brain-derived neurotrophic factor; Exergaming; Obesity