bioihbjkbjnl/mcl2 huggingface dataset:
Acute and Chronic Pain After Video-assisted Thoracoscopic Surgery for Lung Cancer
Condition: Lung Cancer
MeSH terms: Lung Neoplasms; Chronic Pain
Study type: Observational

Summary: 
      The aim of this study is to evaluate whether preoperative CT- guided hookwire localization
      would influence the incidence and intensity of acute and chronic pain after VATS.
    

Detailed description: 
      Postoperative pain after thoracic surgery has gained recognition as a adverse outcome and
      head-scratching problem. The incidence of choric postoperative pain (CPSP) in thoracic
      surgery has been reported to be 20%-80%. However, there has been not an standard treatment
      for CPSP. Many study has showed the risk factors of CPSP in thoracic surgery, such as VATS
      type, operation time, duration of drainage, preoperative pain, repeat surgery, gender,
      postoperative chemotherapy or radiation therapy , etc. It is important that
      moderate-to-severe acute postoperative pain will be transformed into CPSP. That offers a new
      management goal in postoperative pain prevention.CT-guided hookwire localization have been
      proven to be benefical for VATS to diagnose and treat small pulmonary , it can shorten
      operation timing and increase surgery success rate. However, it causes roughly 23.8% severe
      pain and complaints included wire dislodgement, pneumothorax and haemorrhage during and after
      insertion. The question is whether or not the moderate-to-severe acute postoperative pain
      from hookwire localition will change the incidence and intensity of CPSP in VATS.

      Nurses play a pivotal role in advanced practice, research, and education in the field of pain
      management. The pain management of hookwire localization may be a new vison in further
      research.
    

Intervention name(s): Hookwire localization
Intervention type(s): Other
Intervention description(s): Patients were performed CT -guided hook wire localization(20G×120mm, PAJUNK medizintechnologie, Geisingen in Germany). patients were placed on a CT table in a suitable position(supine, prone, lateral) to obtain the shortest needle insertion route for their initial CT scan. Local anesthesia of the skin and planned puncture tract was performed using 10ml Lidocaine 1%. Next, the needle was inserted into or near the pulmonary nodule.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        The institutional review board approved this prospective study. This study included 138
        consecutive patients who underwent CT-guided localization before VATS , of which 69 using
        hookwire (Group A) and 69 without hookwire (Group B). The inclusion criteria were as
        follows: patients were planned to underwent VATS for lung cancer .
      
Keywords: Lung cancer; Video-assisted Thoracoscopic Surgery; hookwire location
Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injection for Postoperative Pain Following Total Hip Arthroplasty.
Condition: Post-Operative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this phase 2 study is to evaluate the efficacy and safety of an analgesic drug
      candidate, VVZ-149 Injections. The study is designed as randomized, double-blind, parallel,
      and placebo-controlled study.
    

Detailed description: 
      VVZ-149 is a dual antagonist of GlyT2 and 5HT2A. GlyT2 blockage increases inhibitory synaptic
      transmission by glycine in the spinal cord, resulting in a reduction of pain transmissions to
      the brain. 5HT2A blockage decreases descending serotonergic facilitatory modulation on pain
      transmission by the brain and reduces nociceptor activation in peripheral nerves, which are
      primary sources of pain in post-surgical pain. VVZ-149 has been shown to have comparable
      efficacy to morphine in well controlled (blind, complete randomization with a positive
      control) animal studies using rat models of post-operative pain and formalin-induced pain.
      The PK/PD study in animals indicates that therapeutic plasma concentration in human subjects
      will be 600-1,900 ng/ml. A clinical Phase 1 study performed in healthy subjects has shown no
      clinically significant adverse events up to a plasma concentration level of 3,261 ng/ml other
      than brief symptoms of mild nausea or dizziness, and mild somnolence when the plasma exposure
      level is more than 2,000 ng/ml.
    

Intervention name(s): VVZ-149 injections; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): •VVZ-149 injection; water for injection
Other intervention name(s): Colorless, transparent liquid in water for injection; water for injection
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Randomized Study of Fluoxetine in Children and Adolescents With Autism
Condition: Autism
MeSH terms: Autistic Disorder
Study type: Interventional

Summary: 
      OBJECTIVES: I. Evaluate the efficacy of fluoxetine on social and language deficits, global
      severity and compulsive dimensions of children and adolescents with autism.

      II. Assess the effectiveness of this treatment regimen on neurocognitive deficits in this
      patient population.

      III. Compare the baseline compulsive severity and treatment outcome in these patients.
    

Detailed description: 
      PROTOCOL OUTLINE: This is a randomized, double blind, placebo controlled, crossover study.
      All patients receive oral placebo daily during week 0.

      Patients are randomized to receive either oral fluoxetine or oral placebo daily on weeks 1-8.
      Patients then crossover to receive treatment on the other arm during weeks 12-20.

      Completion date provided represents the completion date of the grant per OOPD records
    

Intervention name(s): fluoxetine
Intervention type(s): Drug
Intervention MeSH terms: Fluoxetine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double
Primary purpose: Treatment
Keywords: autism; neurologic and psychiatric disorders; rare disease
Maternal Positioning and Occipitoposterior Fetal Position
Condition: Maternal Distress in Labor; Persistent Occipitoposterior or Occipitoanterior Position; Dystocia; Fetal Position and Presentation Abnormalities
MeSH terms: Dystocia; Congenital Abnormalities
Study type: Interventional

Summary: 
      The aim of the study is to evaluate the efficacy of a specific maternal position to correct
      fetal position in occipito-posterior during the labor.

      The investigators hypothesize that the maternal position described by the Dr de Gasquet
      facilitate the rotation in occipito-anterior during the labor.

      The calculated sample size is 438 participants (219 in each group)
    

Detailed description: 
      Randomized clinical trial
    

Intervention name(s): Specific maternal position during the labor
Intervention type(s): Other
Intervention description(s): women allocated to intervention group will be invited to adopt a posture all fours type:"support on the knees, torso tilted forward, back stretched" for a minimum of 10 minutes. A cushion is placed between the legs of the woman to limit the cuts.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Maternal position; Occipitoposterior position; Labor; Dystocia; Fetal presentation Abnormalities
Human Leukocyte Antigen (HLA) - A*2402 Restricted Peptide Vaccine Therapy in Patients With Advanced Gastric Cancer
Condition: Gastric Cancer
MeSH terms: Stomach Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study it to evaluate the safety and immune response of peptides (URLC10)
      emulsified with Montanide ISA51 in treating patients with unresectable, advanced or recurrent
      gastric cancer.
    

Detailed description: 
      URLC10 has been identified as cancer specific molecules especially in non small cell lung
      cancer using genome-wide expression profile analysis by cDNA microarray technique. In a prior
      study, it has been shown that URLC10 are upregulated in esophageal cancer and gastric cancer
      and other cancer. The investigators identified that peptides derived from these proteins
      significantly induce the effective tumor specific CTL response in vitro. According to these
      findings, in this trial, the investigators evaluate the safety, immunological and clinical
      response of URLC10 peptide vaccine in the patients with gastric cancer. Patients will be
      vaccinated once in one week to the eighth vaccine and will be vaccinated once in two weeks
      from the ninth vaccine. On each vaccination day, the URLC10 peptide (1mg) mixed with
      Montanide ISA 51 will be administered by endodermic injection
    

Intervention name(s): peptide vaccine
Intervention type(s): Biological
Intervention description(s): peptides emulsified with Montanide ISA51
Other intervention name(s): Peptides Drived From URLC10 emulsified with Montanide ISA51
Intervention MeSH terms: Monatide (IMS 3015)
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: peptide vaccine; URLC10
Fluid Overload and Pulmonary Function
Condition: Water-Electrolyte Imbalance; Intensive Care Units; Pediatric; Critical Illness; Length of Stay; Respiratory Failure; Esophageal Atresia
MeSH terms: Esophageal Atresia; Respiratory Insufficiency; Water-Electrolyte Imbalance; Critical Illness
Study type: Observational

Summary: 
      Esophageal atresia is a rare but severe malformation, and it requires early surgery.
      Coloesophagoplasty is surgical repair of the esophageal with an isoperistaltic transverse
      colon graft. In the postoperative period after coloesophagoplasty children require careful
      monitoring of fluid balance, because clinically significant fluid overload can lead to
      dysfunction of various organs and systems.
    

Detailed description: 
      Esophageal atresia (EA) is a defect of the embryogenesis of the laryngotracheal tube. There
      are isolated forms of EA and combinations with a tracheoesophageal fistula (TPF). Esophageal
      plastic surgery with an isoperistaltic transplant from the transverse colon was performed in
      children with EA. After this surgical intervention children require observation in the
      intensive care unit (ICU). During this period, infusion therapy satisfies physiological needs
      and compensates for physiological and pathological losses. However, it is not always possible
      to compensate for the body's fluid needs and maintain a normovolemic state. Thus, fluid
      overload develops. It is based on a pathophysiological process when severe operational stress
      leads to the damage of glycocalyx in the vascular wall. As a result, albumin freely passes
      into the interstitium, and oncotic pressure rises in tissues. Fluid overload in the intra-
      and postoperative period can be a factor in an unfavorable outcome, leading to organ damage,
      as well as death.
    

Observational model: Case-Only
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        40 children with EA with/without TPF, aged from 1 month to 3 years, who underwent
        coloesophagoplasty at the N.F. Filatov Children city Hospital, Moscow, Russia, from
        December 1, 2017 to December 31, 2020.
      
Keywords: Liquid; Liquid overload; Mechanical ventilation; Infant; Preschool Child; Respiratory failure; Coloesophagoplasty; Esophageal atresia
Assessment of Flocked Swabs for the Identification of Group A Streptococcal Pharyngitis
Condition: Streptococcal Infection; Pharyngitis
MeSH terms: Pharyngitis; Streptococcal Infections
Study type: Interventional

Summary: 
      This is a study to to compare traditional fibre wound swabs to more recently developed
      flocked swabs for the identification of Group A streptococcal pharyngitis in children
      presenting to a children's emergency department.
    


Intervention name(s): Flocked swab
Intervention type(s): Device
Intervention model: Single Group Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Diagnostic
Keywords: Flocked swab; Group A streptococcus pharyngitis
Safety, Pharmacodynamic and Pharmacokinetic Effects of QAX576 in Healthy Volunteers.
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is designed to evaluate the safety, pharmacodynamic and pharmacokinetic effects of
      individual escalating intravenous doses of QAX576 in healthy volunteers.
    


Intervention name(s): QAX576
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: pharmacodynamic effects, safety, healthy subjects,; Healthy male and female subjects
The Effect of Pregabalin and Dexamethasone on Acute and Chronic Pain After Lumbar Spinal Surgery
Condition: Pain
MeSH terms: Chronic Pain
Study type: Interventional

Summary: 
      Multimodal analgesia may be important for optimal postoperative pain treatment and
      facilitation of early mobilization and recovery. This study investigated the analgesic effect
      of pregabalin and dexamethasone in patients undergoing lumbar spinal surgery.
    


Intervention name(s): Pregabalin; dexamethasone; placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): pregabalin: 300 mg/day, po, from operative day until third postoperative day.; Dexamethasone 16 mg, intravenous, before induction of anesthesia; vitamin B complex formula
Intervention MeSH terms: Dexamethasone; Pregabalin
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Double (Care Provider, Investigator)
Primary purpose: Supportive Care
Keywords: patients undergoing lumbar spinal surgery
Effect of Modified Playground Environment on Health, Particularly Immune System
Condition: Atopic Disorders; Immune System Diseases
MeSH terms: Immune System Diseases
Study type: Interventional

Summary: 
      Children were exposed to biodiverse material or non-diverse material in sand pits. The two
      arms were compared. Immune response and bacterial markers were followed.
    

Detailed description: 
      Children of age 3-5 were randomly divided into two groups (arms). One received guidance and
      biodiverse material for 20 minutes each day for two weeks. The other received the a similar
      material and guidance but the microbial community in the material was poor in diversity.
      Bacterial community changes and immune system markers were analyzed and compared between the
      two arms. Potential changes in Interleukin 10 was the primary outcome.
    

Intervention name(s): Biodiversity powder; Placebo
Intervention type(s): Other; Other
Intervention description(s): Biodiversity sand contained biodiversity powder that contains a highly diverse and rich microbial community but no known pathogens.; Sand that looks like intervention sand but does not have high biodiversity
Other intervention name(s): Biodiversity sand; Biodiversity intervention; Placebo sand
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: One arm received biodiversity sand and the other arm normal sand.
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: biodiversity intervention; sand box; guidance
Study of Olaparib (Lynparza™) Versus Enzalutamide or Abiraterone Acetate in Men With Metastatic Castration-Resistant Prostate Cancer (PROfound Study)
Condition: Metastatic Castration-resistant Prostate Cancer
MeSH terms: Prostatic Neoplasms
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to evaluate the efficacy and safety of olaparib versus
      enzalutamide or abiraterone acetate in subjects with metastatic castration-resistant prostate
      cancer who have failed prior treatment with a new hormonal agent and have homologous
      recombination repair gene mutations.
    

Detailed description: 
      This is a prospective, multicenter, randomized, open-label, phase 3 trial evaluating the
      efficacy and safety of olaparib versus enzalutamide or abiraterone in subjects with
      metastatic castration-resistant prostate cancer (mCRPC) who have failed prior treatment with
      a new hormonal agent (NHA) and have a qualifying tumor mutation in one of 15 genes involved
      in the homologous recombination repair (HRR) pathway. Subjects will be divided into two
      cohorts based on HRR gene mutation status.

      Approximately 340 subjects will be randomized 2:1 (olaparib : investigator choice of
      enzalutamide or abiraterone acetate) into the trial.
    

Intervention name(s): olaparib; enzalutamide; abiraterone acetate; abiraterone acetate; enzalutamide
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): 300 mg (2x 150 mg tablets) twice daily; 160 mg (4 x 40 mg capsules) once daily; 1,000 mg (4 x 250 mg tablets) once daily; 1,000 mg (2 x 500 mg tablets) once daily; 160 mg (4 x 40 mg tablets) once daily
Other intervention name(s): Lynparza; XTANDI; ZYTIGA; ZYTIGA; XTANDI
Intervention MeSH terms: Olaparib; Abiraterone Acetate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: metastatic castration-resistant prostate cancer (mCRPC); homologous recombination repair (HRR)
Physiotherapy Assessment of Patients Referred to Orthopaedic Surgeon
Condition: Musculoskeletal Pain
MeSH terms: Musculoskeletal Pain
Study type: Interventional

Summary: 
      Many patients with musculoskeletal pain in primary healthcare are referred to orthopaedic
      surgeon, however, a relatively low percentage of these patients are considered suitable for
      orthopaedic intervention.

      Physiotherapists are suitable for musculoskeletal assessments and are used as such in many
      countries i.e. Advanced Practice Physiotherapists or Extended Scope Physiotherapists,
      however, this is not an existing model of care in Sweden. To be able to consider this model
      for implementation in Sweden it is necessary to evaluate it from a healthcare as well as from
      a patient perspective.

      The study is a randomised controlled trial. Overall aim is to evaluate if a orthopaedic
      manual therapy assessment (physiotherapy) assessment of patients referred to orthopaedic
      surgeon bring any changes to referral routines, patient satisfaction and health-related
      variables when compared to standard practice.
    

Detailed description: 
      The study is a randomised controlled trial. Overall aim is to evaluate if a orthopaedic
      manual therapy assessment (physiotherapy) assessment of patients referred to orthopaedic
      surgeon bring any changes to referral routines, patient satisfaction and health-related
      variables when compared to standard practice. Patients were randomised to either
      physiotherapy assessment or standard practice (orthopaedic surgeon assessment).
    

Intervention name(s): Physiotherapy screening; Standard practice
Intervention type(s): Procedure; Procedure
Intervention description(s): Physiotherapy screening.; Orthopaedic surgeon assessment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Physiotherapy; Orthopaedic; Primary care
Effect of Life Kinetik Training on Lower Limb Coordination in Ataxic Patients
Condition: Multiple Sclerosis; Ataxia
MeSH terms: Multiple Sclerosis; Ataxia; Sclerosis
Study type: Interventional

Summary: 
      Coordination is essential for the performance of most daily motor activities. Coordination
      problems are common in MS patients. One of the most commonly reported symptoms is dysmetria
      (limb ataxia). Ataxia is thought to occur in about 80% of MS patients. It leads to
      limitations in daily life activities. Aim of Study: to investigate the effect of life kinetik
      training on lower limb coordination in MS patients with ataxia.
    

Detailed description: 
      Methods: Thirty remitting relapsing Multiple Sclerosis (RRMS) patients from both sexes with
      ataxic symptoms, will be recruited from multiple sclerosis specialized clinic in the
      Neurology department, Faculty of Medicine, Cairo University with EDSS score will be ranged
      from 2 to 4 and SARA score will be ranged from 1 to 10. Lower Extremity Motor Coordination
      Test (LEMOCOT) will be used to assess lower limb motor coordination. They will be randomly
      assigned into two equal groups; control group (GI) will receive selected physical therapy
      program and study group (GII) will receive same program of (GI) in addition to life kinetik
      training.
    

Intervention name(s): physical therapy; life kinetic exercises
Intervention type(s): Other; Other
Intervention description(s): Frenkel's exercises for lower limb, Proprioceptive neuromuscular facilitation for upper limb in the form of rhythmic stabilization; A multimodal training that combines coordinative, cognitive and visual tasks.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: randomized controlled trail
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Multiple Sclerosis; ataxia; coordination; life kinetic exercises
4-drug Nerve Block Versus Plain Local Anesthetic for Knee and Hip Arthroplasty Analgesia in Veterans
Condition: Pain
Study type: Interventional
Phase: Phase 3

Summary: 
      After total joint replacement, early hospital discharge to home (with patients capable of
      continuing a home-based rehabilitation program) is a cost- effective management strategy.
      This project will use improved local anesthetic nerve block techniques to enhance technical
      capability and clinical practice by (i) reducing pain and other morbidities during recovery,
      (ii) improving weight-bearing achievement during in-hospital physical therapy to allow for
      earlier return home, and (iii) continued rehabilitation as an outpatient at home when
      feasible (versus in an extended care facility).
    

Detailed description: 
      Patients will have spinal anesthesia for their hip or knee replacement surgery. They will
      also receive the nerve blocks described above
    

Intervention name(s): Bupivacaine + CBD (clonidine, buprenorphine, dexamethasone); Bupivacaine Only (control arm)
Intervention type(s): Drug; Drug
Intervention description(s): Nerve blocks before surgery of L2-L4 and L4-S3 for Knee replacements Nerve blocks before surgery of L2-L4 for hip replacements; Nerve blocks before surgery of L2-L4 and L4-S3 for Knee replacements Nerve blocks before surgery of L2-L4 for hip replacements
Other intervention name(s): "Marcaine" + CBD (clonidine, buprenorphine, dexamethasone); Marcaine
Intervention MeSH terms: Dexamethasone; Dexamethasone acetate; Clonidine; Buprenorphine; Bupivacaine; BB 1101
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: analgesia,; buprenorphine; clonidine; dexamethasone; bupivacaine; nerve block