bioihbjkbjnl/mcl2 huggingface dataset:
Effectiveness of Video-assisted Cardiopulmonary Resuscitation
Condition: Cardiac Arrest
MeSH terms: Heart Arrest
Study type: Interventional

Summary: 
      Sudden cardiac arrest is a major public health problem worldwide and it is one of the leading
      causes of death in industrialized countries. Emergency Medical Services (EMS) dispatchers
      play an important role to recognize cardiac arrest and give help to the lay first responder
      via telephone CPR (T-CPR) which improves survival rates. The current technology allows the
      live video connection between the scene and the dispatcher which provides the opportunity for
      video-assisted CPR (V-CPR) via the bystander smartphone.

      Effectiveness of V-CPR has only been investigated to a limited extent. Comparing
      effectiveness of V-CPR (effectiveness of chest compression, time parameters eg. time to first
      chest compression) to T-CPR and non-instructed CPR can be useful to implement V-CPR
      technology.
    

Detailed description: 
      Sudden cardiac arrest is a major public health problem worldwide and it is one of the leading
      causes of death in industrialized countries. EMS dispatchers play an important role to
      recognize cardiac arrest and give help to the lay first responder via telephone CPR (T-CPR)
      which improves survival rates. The current technology allows the live video connection
      between the scene and the dispatcher which provides the opportunity for video-assisted CPR
      (V-CPR) via the bystander smartphone.

      Effectiveness of V-CPR has only been investigated to a limited extent. Comparing
      effectiveness of V-CPR (quality of chest compressions: depth, rate, hand position), time
      parameters: time to recognize cardiac arrest, time of check breathing, total no-flow time, to
      first chest compression) to T-CPR and non-instructed CPR can be useful to implement V-CPR
      technology.
    

Intervention name(s): Video-assisted CPR; Telephone-assisted CPR
Intervention type(s): Other; Other
Intervention description(s): Participants in V-CPR group get video-based (vocal and visual) instructions from the dispatcher.; Participants in T-CPR group get voice-based (vocal) instructions from the dispatcher.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Pilot Study on Exercise After Achilles Tendon Rupture
Condition: Achilles Tendon Rupture
MeSH terms: Rupture
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose is to study the effect of early NEuroMuscular EXercise (NEMEX) versus
      conventional treatment (late exercise) in patients with acute non-operative achilles tendon
      rupture (ATR).
    

Detailed description: 
      There is currently no consensus on treatment for achilles tendon rupture with regard to
      surgical or non-surgical treatment. In addition, the optimal time to start exercise treatment
      after the injury, with or without surgery, is not well understood. Animal studies show
      positive effects of early mobilization in tendon healing. Neuromuscular exercise has shown
      better effects than strength exercise in people with knee injury or knee disease. There are
      few studies in humans focusing on exercise as treatment, without surgical intervention, after
      ATR.
    

Intervention name(s): Early Neuromuscular Exercise
Intervention type(s): Other
Intervention description(s): 30 patients are randomized to early neuromuscular exercise (n=15) or treatment as usual, i.e., late exercise (n=15). Both groups are given an orthosis and are instructed to wear this for eight weeks. The experimental group starts with a structured exercise program one week after the diagnosis. The patients attend one training session/week during eight weeks, guided by a physical therapist. The level of training is progressed during this time. The patients in the control group (treatment as usual) are given exercise instructions and information at one occasion; 2 weeks after diagnosis. Both groups are followed up, by a blinded assessor, with valid and reliable self-reported and physical function outcomes at 1, 4, 8 and 16 weeks after injury.
Other intervention name(s): Treatment as usual (late exercise)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Achilles tendon rupture; Non-surgical treatment; Exercise; Neuromuscular training
Peers EXCEL Trial to Improve Glycemic Control
Condition: Type 2 Diabetes
Study type: Interventional

Summary: 
      The purpose of the study is to gather input about the value of adding a newly developed
      diabetes self-management program to an existing diabetes self-management program.
      Participants will self-identify as African-American/Black with type 2 diabetes, and
      prescribed a diabetes medication. Participants can expect to be in the study for 6 months.
    

Detailed description: 
      Both programs utilized in this study focus on topics such as diet, exercise, and stress. Both
      programs offer ideas to manage diabetes symptoms, discuss appropriate exercises, provide
      guidance on healthy eating, review the use of medicine, and offer tips on communicating with
      healthcare providers and voicing concerns to family members.

      The new program is culturally-tailored for African Americans and focuses on helping patients
      take their medicines as prescribed.

      The purpose of this research study is to evaluate this newly developed combined diabetes
      self-management program.
    

Intervention name(s): Peers LEAD; HLWD
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Two group session focusing on beliefs about medicines and diabetes, discrimination/mistrust, and communication with providers, and 2 peer-based phone calls from Ambassadors to occur weekly for weeks 3-8, then bi-weekly for weeks 9-12.; Weekly group sessions for two months. Sessions will last up to 2.5 hours and focus on a different diabetes self-management topic.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: African-American; medication adherence; diabetes self-management
The Impact of Multi-Touch Functional Digital Game on Intelligence and Vitality for the Community-dwelling Elderly
Condition: Aging
Study type: Interventional

Summary: 
      This single-blinded, randomized, controlled trial includes 32 elderly. The participants were
      randomized to intervention(Happy Table) and control(cognitive stimulation activity) groups.
      Each group is divided in 16 participants. In one session, participants in the Happy Table
      group completed 40 minutes of intervention using Happy Table serious game, whereas those in
      the Control group completed 40 minutes of cognitive stimulation game.
    

Detailed description: 
      At the first visit, the subjects are fully informed of the study if appropriate after
      determining whether they meet the selection criteria. This single-blinded, randomized,
      controlled trial includes 32 elderly. The participants were randomized to intervention(Happy
      Table) and control(cognitive stimulation activity) groups. Each group is divided in 16
      participants. In one session, participants in the Happy Table group completed 40 minutes of
      intervention using Happy Table serious game, whereas those in the Control group completed 40
      minutes of cognitive stimulation game.
    

Intervention name(s): Functional digital game training group; Individual cognitive training
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Functional digital game training group is divided in 16 participants. In one session, participants in the functional digital game training group completed 40 minutes of intervention using various functional digital game such as working memory, memory, and attention. (Total 10 session); Functional digital game training group is divided in 16 participants. In one session, participants in the individual cognitive training group completed 40 minutes of intervention using various cognitive training such as working memory, memory, and attention. (Total 10 session)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: Elderly; Functional Digital Game; Multi-touch Game; Intelligence
Menopausal Treatment Using Relaxation Exercises (MaTURE)
Condition: Hot Flushes; Hot Flashes
MeSH terms: Hot Flashes
Study type: Interventional

Summary: 
      Hot flashes occur in as many as two thirds of U.S. women during menopause and are severe
      enough to require treatment in 20%. Although postmenopausal hormone therapy is effective in
      suppressing hot flashes, it is associated with increased risk for a variety of serious
      adverse effects. There is an urgent need for alternative treatments that are effective, safe,
      and easy to use. In this study, the investigators will compare two different types of
      behavioral relaxation therapies, paced respiration and music therapy, for treatment of
      menopausal hot flashes. Effects on frequency of hot flashes, other symptom and
      quality-of-life outcomes associated with hot flashes, and physiologic measures of
      sympathetic/parasympathetic activity will be examined.
    


Intervention name(s): Paced Respiration; Music Therapy
Intervention type(s): Other; Other
Intervention description(s): Practice paced respiration 15 minutes per day for a total of 12 weeks.; Practice music therapy for 15 minutes per day for a total of 12 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Nonoperative Management Protocol in Patients With Blunt Splenic Injuries
Condition: Blunt Injuries
MeSH terms: Wounds and Injuries; Wounds, Nonpenetrating
Study type: Observational

Summary: 
      This study was designed to explore the adverse events and associated risk factors before and
      after protocol-based NOM of BSI over a 12-year period in our institution.
    

Detailed description: 
      The nonoperative management (NOM) protocol with angioembolization (AE) presents a trend in
      dealing with trauma patients with blunt splenic injury (BSI). This study was designed to
      explore the adverse events and associated risk factors before and after protocol-based NOM of
      BSI over a 12-year period.
    

Intervention name(s): Patient before cohort (2005-2010); Patient after cohort (2011-2016)
Intervention type(s): Other; Other
Intervention description(s): The NOM protocol with AE was recognized and accepted after our previous study reported in 2004.; The protocol of NOM became more aggressively and strictly adhered to since 2011.
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        A retrospective study was performed on adult trauma patients with BSI who were admitted
        from 2005 to 2016. The patients were divided into before cohort (2005-2010) and after
        cohort (2011-2016).
A Study Evaluating The Safety Of PF-05280014 And Trastuzumab In Healthy Male Volunteers (REFLECTIONS B327-06)
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is to prove that there is no difference in the number of healthy male volunteers
      that will experience pyrexia (i.e. fever with body temperature of 38°C or higher) within a 24
      hour period after administration of a single dose of 6mg/kg of PF-05280014 or trastuzumab
      sourced from the United States (trastuzumab-US). The study will also compare the safety of
      both drugs.
    

Detailed description: 
      Safety evaluation.
    

Intervention name(s): PF-05280014; Herceptin®
Intervention type(s): Biological; Biological
Intervention description(s): Concentrate for solution for infusion, sterile vial 150 mg, single-dose 6 mg/kg administered as 90-minute infusion on Day 1; Concentrate for solution for infusion, sterile vial 440 mg, single-dose 6 mg/kg administered as 90-minute infusion on Day 1
Other intervention name(s): Trastuzumab-Pfizer; Trastuzumab-US
Intervention MeSH terms: Trastuzumab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Keywords: Trastuzumab; Healthy Male Volunteers; Single-Dose; Phase 1; Biosimilarity
A Study to Test the Safety, Pharmacokinetics, and Pharmacodynamics of Single Ascending Intravenous Doses of UCB0107 in Healthy Male Subjects
Condition: Healthy Male Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of the study is to evaluate the safety and tolerability of single ascending doses
      of UCB0107 administered by intravenous (iv) infusion in healthy male subjects.
    


Intervention name(s): UCB0107; Placebo
Intervention type(s): Drug; Other
Intervention description(s): Pharmaceutical form: solution for infusion
Route of administration: intravenous use; Pharmaceutical form: intravenous infusion
Route of administration: intravenous use
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: Phase 1; UCB0107
Management of Patients With Type 2 Diabetes and Hypertension Using Mobile Health Care System
Condition: Diabetes; Hypertension; Obesity
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether cellular phone based health care system is
      effective in the treatment of diabetes and hypertension.
    

Detailed description: 
      Diabetes care is facilitated by a patient's being engaged in a self-management program with
      the advice and counsel of physicians, but many diabetic patients can not receive the
      continous monitoing and advice from his physician in their every day life. It is very
      difficult to keep up life style modification in their real life.

      Few studies have examined the effects of cellular phone based intervention that provide an
      interactive component daily. Our goal is to test the hypothesis that diabetes and
      hypertension management using cellular phone based health care system would result in
      significant improvement of blood glucose and blood pressure level.
    

Intervention name(s): Mobile Health Care System (DrUB)
Intervention type(s): Device
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Mobile Health Units; Chronic Disease
Efficacy of N-Acetylcysteine in Treatment of Overt Diabetic Nephropathy
Condition: Diabetic Nephropathy; Chronic Kidney Disease; Diabetes Type 2
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic; Diabetic Nephropathies; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      Diabetic nephropathy has become the single most frequent cause of end-stage renal disease.

      On a molecular level, at least five major pathways have been implicated in glucose-mediated
      vascular and renal damage and all of these could reflect a single hyperglycaemia-induced
      process of overproduction of reactive oxygen species.

      Recent studies have shown that inflammation, and more specifically pro-inflammatory cytokines
      play a determinant role in the development of micro- vascular diabetic complications, most of
      the attention has been focused on the implications of TNF-α in the setting of diabetic
      nephropathy.

      Glutathione is the most abundant low-molecular-weight thiol, and Glutathione/ glutathione
      disulfide is the major redox couple in animal cells.

      N-acetylcysteine is effective precursors of cysteine for tissue Glutathione synthesis.

      Not only does N-acetylcysteine exhibit antioxidant properties, but it may also counteract the
      glycation cascade through the inhibition of oxidation.

      N-acetylcysteine can also reduce the apoptosis elicited by reactive oxygen species .

      Indeed, N-acetylcysteine has been shown to inhibit reactive oxygen species induced mesangial
      apoptosis and to be able to protect cells from glucose-induced inhibition of proliferation.
    


Intervention name(s): N-acetylcysteine
Intervention type(s): Drug
Intervention description(s): 600 mg of effervescent N-acetylcysteine tablet twice per day for three months
Intervention MeSH terms: Acetylcysteine; N-monoacetylcystine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: diabetic nephropathy; proteinuria; antioxidant
Crossover Bioequivalence Study of Quetiapine Fumarate 25 mg Tablets Under Fed Conditions
Condition: Bipolar I Disorder
MeSH terms: Malnutrition
Study type: Interventional

Summary: 
      The objective of this study was to prove the bioequivalence of Roxane Laboratories'
      Quetiapine Fumarate 25 mg Tablet under fed conditions.
    


Intervention name(s): Quetiapine Fumarate
Intervention type(s): Drug
Intervention description(s): 25 mg tablet
Other intervention name(s): Seroquel
Intervention MeSH terms: Quetiapine Fumarate
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
LIPT - Liraglutide in Polycystic Ovary Syndrome
Condition: Polycystic Ovary Syndrome; Cardiovascular Disease
MeSH terms: Polycystic Ovary Syndrome; Cardiovascular Diseases; Syndrome
Study type: Interventional
Phase: Phase 4

Summary: 
      Polycystic ovary syndrome (PCOS) affects 5-10% of women in fertile age. PCOS is associated
      with metabolic syndrom, diabetes and and increased risk og cardiovascular disease.

      The study investigates the effect af intervention with GLP-1-analog on risk markers of
      cardiovascular disease in women with PCOS.

      70 women will be included in af RCT.

      Hypothesis: GLP-1-analog treatment in women with PCOS (without diabetes) will result in a
      beneficial reduction in risk markers of vascular thrombosis and early cardiovascular disease.
    


Intervention name(s): Liraglutide for 26 weeks; placebo
Intervention type(s): Drug; Drug
Intervention description(s): GLP-1-analogue Liraglutide s.c. 1,8mg daily for 26 weeks; Placebo s.c. daily for 26 weeks
Intervention MeSH terms: Liraglutide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Assess Biomarkers of Tobacco Exposure and Nicotine Pharmacokinetics in Smokers After a 5-Day In-Clinic Confinement Switch to an Electronic Cigarette or Nicotine Gum
Condition: Smoking
Study type: Interventional

Summary: 
      A single-center, randomized, controlled, switching, open-label, parallel cohort study.
      Smoking subjects will be confined to a clinic for 9 days. During their stay, baseline
      assessments during ad libitum smoking will occur for the first 3 days. Following baseline,
      subjects will be switched to either an Electronic Cigarette or Nicotine Gum, and post-product
      switch assessments will occur for 6 days.
    


Intervention name(s): Usual Brand Cigarette; Electronic Cigarette #1; Electronic Cigarette #2; Leading U.S. Nicotine Gum
Intervention type(s): Other; Other; Other; Other
Intervention description(s): Combustible cigarette brand style smoked most frequently by subject; Electronic cigarette; Electronic cigarette; 4 mg nicotine polacrilex gum
Other intervention name(s): UB Cigarette; VUSE® Digital Vapor Cigarette (original flavor, 29 mg nicotine); VUSE® Digital Vapor Cigarette (menthol flavor, 26 mg nicotine)
Intervention MeSH terms: Menthol; Nicotine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: biomarkers of tobacco exposure; exposure; tobacco; nicotine; nicotine gum; electronic cigarette; e-cig
A Study to Determine if a New Malaria Vaccine is Safe and Induces Immunity Among Kenyan Adults, Young Children and Infants
Condition: Malaria,Falciparum
MeSH terms: Malaria; Malaria, Falciparum
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This is a clinical trial to evaluate the safety and immunogenicity of R21/MM in healthy
      Kenyan participants from the different age groups.Participants will receive 3 vaccinations 4
      weeks apart.
    

Detailed description: 
      The study includes three age groups:

      Group 1: healthy adults (18-45 years) Group 2: young children (aged 1-5 years) Group 3:
      infants (aged 5- <12 months of age) Each group will receive 3 vaccine doses which will be
      4-weeks apart. A booster dose will be administered at 9-25 months post 3rd dose.

      The trial is funded by The European & Developing Countries Clinical Trials Partnership
      (EDCTP), European Union, ref: RIA2016V-1649 MMVC
    

Intervention name(s): R21 in Matrix- M adjuvant vaccine
Intervention type(s): Biological
Intervention description(s): R21: Protein particle malaria vaccine candidate in Matrix-M: Saponin based vaccine adjuvant.
Intervention MeSH terms: Adjuvants, Vaccine
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Perennial Allergic Rhinitis Study In Pediatric Subjects
Condition: Rhinitis, Allergic, Perennial
MeSH terms: Rhinitis; Rhinitis, Allergic; Rhinitis, Allergic, Perennial
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to determine if the investigational drug is effective and safe
      in children with perennial allergic rhinitis.
    

Detailed description: 
      A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate
      the Safety and Efficacy of Once-Daily, Intranasal Administration of GW685698X Aqueous Nasal
      Spray 50mcg and 100mcg for 12 Weeks in Pediatric Subjects Ages 2 to <12 Years with Perennial
      Allergic Rhinitis (PAR)
    

Intervention name(s): GW685698X
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Perennial allergic rhinitis; pediatric
A Open-label, Drug-Drug Interaction With Maraviroc (DDI)
Condition: Infection, Human Immunodeficiency Virus
MeSH terms: Acquired Immunodeficiency Syndrome; HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a Phase 1, open-label, single sequence, two-way interaction study in healthy male and
      female subjects. For the effect of maraviroc on the pharmacokinetics (PK) of BMS-626529 (the
      active moiety of BMS-663068), there is no formal hypothesis to be statistically tested. The
      purpose of this assessment is to estimate the effect of maraviroc on the PK of BMS-626529
      when coadministered in healthy subjects. For the effect of BMS-663068 on the PK of maraviroc,
      the hypothesis to be statistically tested is that BMS-663068 will not have a clinically
      significant effect on the PK of maraviroc when coadministered in healthy subjects.
    


Intervention name(s): BMS-663068; Maraviroc
Intervention type(s): Drug; Drug
Intervention description(s): BMS-663068; Maraviroc
Intervention MeSH terms: Maraviroc; Fostemsavir
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment