bioihbjkbjnl/mcl2 huggingface dataset:
Dietary Lipids as Primary Modulators of Carotenoid Absorption in Vegetables
Condition: Absorption of Carotenoids From Vegetables
Study type: Interventional

Summary: 
      The purpose of this research study is to determine how dietary fats and oils influence the
      absorption of beneficial plant pigments (carotenoids) from vegetables. The study will examine
      changes in blood carotenoids in response to eating a salad with different fats/oils.
    


Intervention name(s): Soybean Oil; Canola Oil; Butter
Intervention type(s): Other; Other; Other
Intervention description(s): Depending on the experimental group assigned, each subject which will be given one of three different amounts of soybean oil that is added to a salad.; Depending on the experimental group assigned, each subject which will be given one of three different amounts of canola oil that is added to a salad.; Depending on the experimental group assigned, each subject which will be given one of three different amounts of butter that is added to a salad.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
ELAZOP Switching Study in Korea
Condition: Open Angle Glaucoma
MeSH terms: Glaucoma; Glaucoma, Open-Angle
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to assess the safety and efficacy of switching to ELAZOP from
      prior pharmacotherapy in patients with open-angled glaucoma.
    


Intervention name(s): Elazop (Azarga)
Intervention type(s): Drug
Intervention description(s): Administer one drop of ELAZOP in treated eye(s) twice a day for up to 12 weeks
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Open angle glaucoma; OAG; Elazop; Azarga; Brinzolamide/Timolol combination
Check Yourself Study
Condition: Health Risk Behaviors; Health Care Services Quality of Care
Study type: Interventional

Summary: 
      The proposed study is a randomized controlled trial that compares the effectiveness of an
      electronic personalized health screening app incorporating motivational feedback (i.e.,
      "Check Yourself") to usual care. The purpose of this study is to determine whether Check
      Yourself is more effective than usual care in reducing health risk behaviors and improving
      quality of care among adolescents receiving primary health care services.
    


Intervention name(s): Check Yourself App with Feedback
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Treatment With Intent to Generate Endovascular Reperfusion
Condition: Ischemic Stroke
MeSH terms: Ischemic Stroke
Study type: Interventional

Summary: 
      Tigertriever is a CE marked mechanical revascularization device indicated to restore blood
      flow by removing thrombus from a large intracranial vessel in patients experiencing ischemic
      stroke within 8 hours of symptom onset. Patients who are ineligible for IV t-PA or who fail
      IV t-PA therapy are candidates for treatment.

      The objective of the TIGER Study is to evaluate the safety and effectiveness of the
      Tigertriever device in restoring blood flow in the neurovasculature by removing thrombus in
      patients experiencing ischemic stroke due to a large vessel occlusion (LVO). This study is
      designed to support substantial equivalence to approved and marketed products such as the
      Solitaire or Trevo Retriever.
    


Intervention name(s): Tigertriever revascularization device
Intervention type(s): Device
Intervention description(s): Mechanical Thrombectomy
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Mechanical thrombectomy,; Brain; Brain clot; Brain infarction; Cerebral ischemia; Neurovascular intervention; Revascularization; Reperfusion; Stent retriever; Tigertriever; Stroke; Rapid Medical
A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based
Condition: Kidney Transplantation
Study type: Interventional
Phase: Phase 3

Summary: 
      The primary purpose is to assess the benefits and risks of changing from Cyclosporine or
      Tacrolimus to Belatacept between 6-60 months after kidney transplant.
    


Intervention name(s): Belatacept; Tacrolimus; Cyclosporine
Intervention type(s): Drug; Drug; Drug
Other intervention name(s): BMS 224818; Nulojix®
Intervention MeSH terms: Cyclosporine; Abatacept; Tacrolimus; Cyclosporins
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Smoking Termination Enhancement Project (STEP)
Condition: Smoking
Study type: Interventional
Phase: Phase 3

Summary: 
      The primary aim of this research study (STEP) is to compare the effectiveness of two smoking
      cessation programs that integrate counseling and nicotine replacement with either a wellness
      program or exercise. This will help us to determine whether different lifestyle interventions
      (wellness or exercise) help increase the effectiveness of current standard programs for
      smoking cessation.
    


Intervention name(s): Cognitive Behavioral Treatment; Nicotine Patch; Wellness Program; Aerobic Exercise
Intervention type(s): Behavioral; Drug; Behavioral; Behavioral
Intervention description(s): Cognitive Behavioral Treatment; Nicotine Patch; Wellness Program; Aerobic Exercise
Intervention MeSH terms: Nicotine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Assessment of CRYOBEAUTY MAINS ET DECOLLETE Versus Liquid Nitrogen Cryotherapy, in the Treatment of Solar Lentigines
Condition: Solar Lentigo
MeSH terms: Lentigo
Study type: Interventional

Summary: 
      This study evaluates the performance of new technology "CRYOTHERAPY MAINS ET DECOLLETE"
      against a classic cryotherapy "Nitrogen Liquid " to treat solar lentigines.

      The hands and the neckline will be randomised, either left or right side and treated by two
      cryotherapy devices:

        1. CRYOTHERAPY MAINS ET DECOLLETE is the device under evaluation.

        2. Liquid nitrogen is a comparator device.
    


Intervention name(s): CRYOBEAUTY MAINS ET DECOLLETE; Liquid nitrogen
Intervention type(s): Device; Device
Intervention description(s): The intervention lasts up to 6.5 s. The device will be applied on spots <6 mm which are previously selected by the investigator team.; The intervention lasts up to 3 s. The liquid is stored in well-isolated recipients. Each patient has his recipient to avoid contamination. The investigator applies on spots <6 mm a small amount of nitrogen liquid.
Other intervention name(s): Azote médical liquide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Impact and Mechanism of Depression on Cardio-cerebral Vascular Events and Arteriovenous Fistula Dysfunction in MHD Patients
Condition: Cardio-cerebral Vascular Events; Arteriovenous Fistula Dysfunction
MeSH terms: Stroke; Arteriovenous Fistula; Fistula; Depression
Study type: Observational

Summary: 
      Depression is a common psychiatric disorder in patients on maintenance hemodialysis (MHD). It
      may contribute to poor prognosis in a number of ways, including its effect on platelet
      function. We aimed to investigate the impact and underlying mechanisms of depression on the
      occurrence of cardio-cerebral vascular events (CCVE) and dysfunction of arteriovenous fistula
      (DAVF) in MHD patients.

      In this study, MHD patients were recruited and divided into depression and non-depression
      groups using the Hamilton Depression Scale (HAMD) in this prospective cohort study. Their
      clinical and laboratory indicators were collected and the occurrence of CCVE and DAVF were
      recorded through clinical follow-up, and analyzed, and the differences and possible
      influencing factors of CCVE and DAVF occurrence were assessed between the two groups of
      patients.
    


Intervention name(s): depression
Intervention type(s): Other
Intervention description(s): The score of Hamilton Rating Scale for Depression (HAMD) is ≥8
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients undergoing maintenance hemodialysis were recruited from the First Affiliated
        Hospital of Chongqing Medical University in China.
      
Keywords: maintenance hemodialysis patients; depression; cardio-cerebral vascular events; arteriovenous fistula dysfunction; platelet
Topical Keratin in Treating Radiation Dermatitis in Patients With Breast Cancer
Condition: Breast Carcinoma; Radiation-Induced Dermatitis
MeSH terms: Breast Neoplasms; Dermatitis; Radiodermatitis
Study type: Interventional

Summary: 
      This randomized pilot clinical trial studies how well topical keratin works in treating
      radiation dermatitis in patients with breast cancer. Radiation dermatitis is a skin condition
      that is a common side effect of radiation therapy. The affected skin becomes painful, red,
      itchy, and blistered. Topical keratin may help to improve skin appearance and hydration in
      patients with breast cancer.
    

Detailed description: 
      PRIMARY OBJECTIVES:

      I. To determine a preliminary estimate of the improvement of skin's natural barrier, decrease
      of dehydration, and reduction in the appearance of inflammation associated with radiation
      therapy (RT) skin toxicity as well as patients' satisfaction with their skin after the
      application of the medical device topical keratin (KeraStat Cream) during RT in breast cancer
      patients.

      OUTLINE: Patients are randomized to 1 of 2 groups.

      GROUP I: Patients receive topical keratin topically at least twice daily (BID) until the end
      of radiation therapy (approximately 3-6 weeks).

      GROUP II: Patients receive standard of care as directed by radiation oncologist until the end
      of radiation therapy (approximately 3-6 weeks).

      After completion of study treatment, patients are followed up at 4-6 weeks.
    

Intervention name(s): Best Practice; Quality-of-Life Assessment; Topical Keratin
Intervention type(s): Other; Other; Device
Intervention description(s): Receive standard of care; Ancillary studies; Given topically
Other intervention name(s): standard of care; standard therapy; Quality of Life Assessment; KeraStat
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Omega-6 to Omega-3 Fatty Acid Ratio and Higher Order Cognitive Function in 7-to 9-year-olds
Condition: Typical Development
Study type: Observational

Summary: 
      The purpose of this study is to investigate the role of the ratio of omega-6 to omega-3 fatty
      acids on executive functions. The investigators hypothesize that participants ages 7-9 years
      with a ratio closer to 4:1 will do better on tests of executive function than participants
      with a ratio closer to the purported Western diet norm of 15:1.
    


Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        7-9 year olds
      
Biospecimen description: 
      No biospecimens will be collected.
PACE4 in Thyroid Cancer
Condition: Thyroid Nodule
MeSH terms: Thyroid Neoplasms; Thyroid Nodule; Thyroid Diseases
Study type: Observational

Summary: 
      The investigation of thyroid nodules is limited by the fact that up to 49% of the fine needle
      aspirations (FNA) performed are of "indeterminate cytological signification". Moreover, no
      fully reliable molecular marker for thyroid cancer have been described. The goal of this
      project is to study the expression of a specific kind of protein convertase in benign and in
      malignant thyroid nodules to determine its potential as a biomarker.
    

Detailed description: 
      Patients that underwent thyroidectomy at the CIUSSS de l'Estrie-CHUS will be recruited and
      classified according to the pathological diagnosis. An immunohistochemistry technique,
      developed and calibrated for the specific protein convertase studied, will be undertaken.
      Results will be interpreted by a specialized pathologist.
    

Intervention name(s): Immunohistochemistry
Intervention type(s): Diagnostic Test
Intervention description(s): Immunohistochemistry procedure on the formalin-fixed, paraffin-embedded tissue.
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Patients from the territory of the CIUSSS de l'Estrie - CHUS, that underwent a subtotal or
        total thyroidectomy
      
Biospecimen description: 
      Formalin-fixed, paraffin-embedded thyroid tissue, kept at the CIUSSS de l'Estrie - CHUS
      Pathology archives
    
Keywords: Thyroid Neoplasm; Thyroid Cancer; Bethesda Classification; Biomarkers; Protein convertase
Induced Pluripotent Stem Cells for Disease Research
Condition: Hirschsprung Disease
MeSH terms: Hirschsprung Disease
Study type: Observational

Summary: 
      The aim of this study is to determine the contribution of genetic factors to the pathogenesis
      of diseases, including diseases such as Parkinson's disease, Hirschsprung's disease, and
      autism. Patient-derived cellular models of diseases will be developed, which will require the
      collection of blood samples from patients and healthy individuals in order to generate
      induced pluripotent stem cells (iPSCs) for the development of iPSC-derived human cell
      cultures. These human cellular models will be phenotyped using a variety of methods,
      including cellular, molecular, and biochemical assays. Because these human cellular models
      will retain the genetic background from the patients and control subjects, this will allow us
      to determine the contribution of genetics to disease phenotypes. Such disease-specific
      pluripotent stem cell lines will be invaluable tools for many basic and translational
      research applications, including pathophysiological studies in a developmental context, and
      innovation and screening of small molecule drugs capable of reversing the disease phenotype
      and potentially leading to a cure for a broad range of diseases, where appropriate in vitro
      or in vivo disease models do not exist.
    


Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Individuals with Hirschsprung disease and their unaffacted family members
      
Biospecimen description: 
      whole blood
    
Keywords: Hirschsprung Disease
Neuro-modulation of the Depressed Brain Using Working Memory Training and Transcranial Direct Current Stimulation (tDCS)
Condition: Depression
MeSH terms: Depression
Study type: Interventional
Phase: Phase 2

Summary: 
      The goal of this project is to train currently major depressed patients on fundamental
      aspects of working memory while the investigators administer transcranial Direct Current
      Stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) during these training
      sessions. This working memory training would be performed using adaptive Paced Auditory
      Serial Addition Tasks (PASAT). The effects after two weeks of working memory training
      combined with tDCS or sham placebo (10 sessions) will be measured on different variables,
      each measured at the start and at the end of the two weeks of training. The investigators
      expect the greatest anti depressant results and cognitive enhancements in the group of
      depressed patients that received tDCS combined with working memory training.
    


Intervention name(s): active tDCS and working memory training; sham tDCS and working memory training
Intervention type(s): Other; Other
Intervention description(s): This group will receive 2.0 mA anodal DC stimulation over the left DLPFC and cathodal stimulation over the right DLPFC. During the stimulation, this group will be trained on working memory processes. Sessions will be scheduled daily for two consecutive weeks.; This group will receive sham stimulation (e.g., identical stimulation set-up but no electric current is sent through the electrodes). Patients however receive the real working memory training, daily, for two weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Anti-depressant effects
An Assessment of Residual Spherical Aberration, Postoperative Total High Order Aberrations, and Functional Vision Correlation Following Intraocular Lens (IOL) Implantation
Condition: Cataracts
MeSH terms: Cataract
Study type: Interventional

Summary: 
      The purpose of this study was to evaluate total residual spherical aberration (TSA) post-IOL
      implantation, and to determine if an association exists between TSA, postoperative high order
      aberrations (HOA), and functional vision following IOL implantation in patients grouped by
      pre-operative corneal spherical aberration (CSA).
    

Detailed description: 
      Patients will be grouped by pre-operative corneal spherical aberration (CSA) measures, i.e.,
      ≤0.230 micron and ≥0.270 micron.
    

Intervention name(s): Acrysof IQ (SN60WF) IOL
Intervention type(s): Device
Intervention description(s): Acrysof IQ (SN60WF) intraocular lens implanted in the capsular bag of the eye during cataract surgery. The IOL is intended for the lifetime of the patient. Unilateral (one eye only) implantation is planned.
Other intervention name(s): Acrysof® IQ Model SN60WF
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: intraocular lens; cataracts; total residual spherical aberration; high order aberrations
Use of a Colon Irrigation Device as a Preparation for a Colon Visualization Procedure
Condition: Screening Colonoscopy
Study type: Interventional

Summary: 
      A prospective, single center, study to evaluate the effectiveness of the HyGIeaCare Prep when
      used in combination with the PillCam COLON; the hypothesis is that the HyGIeaCare Prep will
      be easier for the patients to tolerate, and the results will be as good as the existing oral
      preparation.
    

Detailed description: 
      Patients who agree to participate in the study will have their HyGIeaCare procedure and then
      will present to the PillCam COLON room, in the same suite for the PillCam COLON procedure.

      The commercial preparations for the PillCam COLON procedure will be the same, except the
      HyGIeaCare procedure will replace the split polyethylene glycol-electrolyte solution
      preparation.

      2-days prior:

        -  Normal diet

        -  10 glasses of liquid

           1-day prior:

        -  Clear liquid diet all day

        -  Dulcolax 2 tabs at 2pm and 2 tabs at 8pm

        -  Nothing by mouth after midnight

      Day of Procedure:

        -  6am- Dulcolax 2 tabs

        -  8am- HyGIeaCare Procedure

        -  9am- ingest PillCam Colon

        -  10am- ingest Reglan

        -  At small bowel detection, drink 10oz SUPREP and 32oz water

        -  3hrs later- drink 10oz SUPREP and 32oz water

        -  2hrs later- insert suppository

        -  2hrs later- light meal
    

Intervention name(s): HyGIeaCare colon irrigation
Intervention type(s): Device
Intervention description(s): PillCam COLON for visualization of bowel lining
Other intervention name(s): PillCam COLON
Intervention model: Single Group Assignment
Intervention model description: HyGIeaCare colon irrigation procedure and PillCam COLON procedure
Masking: None (Open Label)
Primary purpose: Device Feasibility
Providing Personalized Health and Individual Lifestyle Enhancing Solutions (Prophiles) in CVD
Condition: Cardiovascular Diseases
MeSH terms: Cardiovascular Diseases
Study type: Interventional

Summary: 
      The objective of the proposed project is to evaluate the usability, acceptability, and
      adherence of a lifestyle and behavioral self-tracking and ePersuasive tool aimed at
      improving: 1) adherence to diet/nutrition (<1500 mg of sodium/day and less than 10% daily
      free sugar intake), physical activity (PA) (150 minutes of moderate PA/week), and sleep
      guidelines (7-8 hours of sleep/day)-- and 2) control 3% reduction in systolic BP and glucose
      from baseline to end of study follow-up after 2 months (exploratory objective) in a sample of
      20 patients with Hypertension or Diabetes. The study will utilize a Step-Wedge Design where
      the 20 patients will be divided into 4 wedges (5 patients in each wedge).
    


Intervention name(s): Lifestyle Management; Control Group
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Will use passive ubiquitous sensing through FitBit to 1)learn behavioral profiles of subjects who have pre-HTN/HTN and/or pre-diabetes /Diabetes 2) provide personalized recommendations through mobile based messaging app that will increase the likelihood of engaging in health diet/nutrition, physical activity and sleep practices; will receive standard medical care where research assistant will give pamphlets, with one size fits all recommendations for diet/nutrition, physical activity and sleep, to 10 subjects with comorbid HTN and T2D.
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Bilateral and Unilateral Horizontal Strabismus Surgery
Condition: Strabismus
MeSH terms: Strabismus
Study type: Interventional

Summary: 
      This study was done in alternating strabismus patients to compare symmetrical muscle surgery
      and asymmetrical one as regard efficacy and lateral incomitance after surgery
    


Intervention name(s): symmetrical and asymmetrical horizontal strabismus surgery
Intervention type(s): Procedure
Intervention description(s): surgery was done on the medial rectus muscle on both eyes, lateral rectus muscle in both eyes or medial and lateral rectus muscle in one eye
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment