bioihbjkbjnl/mcl2 huggingface dataset:
Intrauterine Injection of Human Chorionic Gonadotrophin and Pregnancy Rate in ICSI
Condition: Repeated Implantation Failure
Study type: Interventional

Summary: 
      Despite recent advances in clinical and laboratory techniques of Assisted Reproductive
      Technology (ART), the pregnancy rate remains around 30% per cycle. It has been estimated that
      50% to 75% of lost pregnancies are due to failure of implantation.

      The process of implantation is a locally controlled paracrine/juxtacrine-mediated phenomenon.
      Successful implantation depends on the synchronized "cross-talk" between a functional
      blastocyst and a "receptive" endometrium. This process leads to apposition, attachment and
      invasion of embryos and subsequent normal placentation. So the objective of this study is
      investigate the impact of intrauterine injection of human chorionic gonadotropin (hCG) at the
      day of ovum pick-up on implantation and pregnancy rates in patients with recurrent
      implantation failure.
    

Detailed description: 
      The endometrium can only support implantation during a discrete period of about 6 to 9 days
      after LH peak; termed the "window of implantation". During this period endometrial glandular
      epithelium is differentiated into a highly secretory state with the production of various
      cytokines and growth factors that facilitate implantation. In fact, several substances
      secreted from the embryo or the endometrium affect implantation. These include cyclic
      adenosine monophosphate, relaxin, gonadotropin, prostaglandin E2, and glycoprotein hormones.

      Human chorionic gonadotropin (hCG) is the earliest blastocyst-derived signals received by the
      endometrium; it is transcribed as early as the 2-cell embryo stage. It is produced by the
      trophectodermal cells of the preimplantation blastocyst. Recent evidence suggests that hCG is
      also produced by the endometrial epithelial cells during the secretory.

      It has been shown that intrauterine injection of hCG before embryo transfer significantly
      improves pregnancy rates in IVF/ICSI cycles.
    

Intervention name(s): Human chorionic gonadotropin
Intervention type(s): Drug
Intervention description(s): intrauterine injected of 500 IU of hCG on the day of ovum pick-up and
Other intervention name(s): Chorimone; pregnyl
Intervention MeSH terms: Chorionic Gonadotropin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: human chorionic gonadotropin
Protein Supply in Elderly
Condition: Muscle Synthesis
Study type: Interventional

Summary: 
      Stimulating overnight muscle protein synthesis, might augment muscle hypertrophy, increase
      mitochondrial mass, and/or improve muscle tissue repair. The goal of this proposal will be to
      provide further insight into the responsiveness of the muscle protein synthetic machinery to
      food intake in relation to age.
    


Intervention name(s): Protein
Intervention type(s): Dietary Supplement
Intervention description(s): Protein drink
Other intervention name(s): casein vs water
Intervention MeSH terms: Caseins
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
A Study to Evaluate the Efficacy and Safety of INCB054707 in Participants With Vitiligo
Condition: NonSegmental Vitiligo
MeSH terms: Vitiligo
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate the efficacy and safety of INCB054707 over a 24-week
      placebo-controlled double-blind treatment period, followed by a 28-week double-blind
      extension period in participants with nonsegmental vitiligo.
    


Intervention name(s): INCB054707; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): INCB054707 will be administered once daily; Placebo or INCB054707 will be administered once daily
Other intervention name(s): Povorcitinib
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Effect of Intravenous Fluid Supplementation on Serum Bilirubin and Cardiorespiratory Parameters in Preterm Infants During Phototherapy
Condition: Hyperbilirubinemia
MeSH terms: Hyperbilirubinemia
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The aim of the study was to evaluate the influence of a systematic extra intravenous fluid
      supplementation during phototherapy in comparison to a fluid supplementation due to short
      term demand in preterm infants.
    

Detailed description: 
      60 preterm infants (GA ≤ 32 week) were assigned randomly to either receive a fluid
      supplementation due to short term demand (control group, n=30;) or a 20% extra fluid
      supplementation (study group, n=30) during intermediate phototherapy.

      Collected data:

        -  cardiorespiratory parameters(heart rate, blood pressure, SaO2 and capillary refill time,
           breathing rate, temperature) and a pain score was completed at the first day of
           phototherapy

        -  The maximum total serum bilirubin levels (TSB) within one week after onset of
           phototherapy
    

Intervention name(s): extra fluid/iv fluid supplementation during phototherapy; Non extra fluid
Intervention type(s): Other; Other
Intervention description(s): The study group received an extra intravenous fluid intake of 20% of the total fluid demand per 24 hours of NaCl 0,9% during each two hour period of phototherapy (12h total per day). The extra fluid intake was interrupted during the 12 hours break of phototherapy.; Control placebo The control group received the previous fluid regime, as intravenous fluid was given constantly, without a specific guideline according to extra fluid intake.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: preterm infants < 32 weeks of gestation
Evaluation and Treatment Planning of Patients With PAP Using Thrive Ultra Short Echo Time MRI and CT
Condition: Pulmonary Alveolar Proteinosis
MeSH terms: Pulmonary Alveolar Proteinosis
Study type: Observational

Summary: 
      The purpose of this study is twofold: to assess routine cat scan (CT) imaging as a biomarker
      for removal of lipoprotein surfactant via lung lavage (where CT is the gold-standard imaging
      technique for density quantification), and to utilize a novel UTE MRI protocol to similarly
      quantify surfactant removal. This study will also serve to generate baseline scanning that
      may aid in developing analytical tools to evaluate and treat specific lung regions of
      patients with PAP.
    

Detailed description: 
      This study will evaluate x-ray CT as a biomarker for surfactant lavage removal and evaluate
      an UTE-Thrive MRI protocol at CCHMC as an imaging alternative to CT. Potential subjects who
      meet study criteria will be identified by the Pulmonary physicians at Cincinnati Children's
      Hospital Medical Center (CCHMC) and University of Cincinnati (UC) through their clinic
      patients. The study will include two research MRIs (one pre lavage and the second 24 to 72
      hours after the first lung lavage) and if there is a clinical CT performed pre lavage, then
      one research CT will also be performed with the second research MRI. All image analysis will
      be quantitative. Whole-lung and regional density will be calculated and evaluated before and
      after lung lavage, for a quantification of changes in density in the left lung and right lung
      separately. Since the one lung will serve as control, it will allow precise error estimation
      (which we expect to be quite small and largely related to differences in lung volume). One
      purpose of this protocol is to further refine and develop ultra-short echo time (UTE) MRI
      techniques since Pulmonary Alveolar Proteinosis (PAP) patients may have multiple lavage
      sessions per year. A subject may be eligible to re-enroll to participate multiple times if
      the total number of research CTs for all enrollments is one or less for that subject.
    

Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients with Pulmonary Alveolar Proteinosis
      
Keywords: PAP; Pulmonary Alveolar Proteinosis; Pulmonary; Patients
The Effects of Social Media on Food Intake and Behaviour
Condition: Sedentary Lifestyle; Hunger; Eating
Study type: Interventional

Summary: 
      Participants will be exposed to 3 conditions, in random order:

        1. A Facebook page where 70% of posts are related to food.

        2. A Facebook page where only 20% of posts are related to food.

        3. A control condition (colouring quietly).

      During each of the above conditions participants will be provided with identical snacks. The
      snacks will be weighed before and after each condition, to determine whether there is a
      change in food intake across the 3 conditions.
    


Intervention name(s): Facebook; Facebook + Food; Colouring
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Participants will spend 30 minutes on a Facebook page that is primarily non-food related posts.; Participants will spend 30 minutes on a Facebook page that is food related posts.; Participants will spend 30 minutes colouring quietly.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Efficacy of Acupuncture and Moxibustion Treatment in Patients With Active Crohn's Disease
Condition: Crohn's Disease; CAM
MeSH terms: Crohn Disease
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether acupuncture or moxibustion therapies are
      effective in the treatment of active Crohn's disease. meanwhile, we are aim to observe the
      content of Inflammatory factors and Neurotransmitter before and after acupuncture and
      moxibustion therapy.
    

Detailed description: 
      The purpose of this study is to determine whether acupuncture or moxibustion therapies are
      effective in the treatment of active Crohn's disease. meanwhile, we are aim to observe the
      content of Inflammatory factors and Neurotransmitter before and after acupuncture and
      moxibustion therapy.

      Through treating active Crohn's disease by acupuncture and moxibustion therapies for 12
      weeks, we are aim to observe the efficiency and the probably change of Inflammatory factors
      and Neurotransmitter of colonic mucosa and we may elucidate the mechanism of the efficiency
      of acupuncture and moxibustion therapy.
    

Intervention name(s): Treatment Group; Control Group
Intervention type(s): Other; Other
Intervention description(s): patients receive herbs-partitioned moxibustion for 2 cones and acupuncture for 30 minutes，3 times a week for 12 weeks; patients receive shallow needing and bran-partitioned moxibustion with the stimulation same to the treatment group.
Other intervention name(s): acupuncture and moxibustion group; acupuncture and Herbs-partitioned moxibustion group; Sham acupuncture and moxibustion group
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Crohn's disease,acupuncture,moxibustion,inflammation factors
Appetite Responses to Cereal Products
Condition: Satisfaction, Consumer
Study type: Interventional

Summary: 
      The purpose of this clinical trial is to investigate appetite responses to 2 cereal products
      in healthy adults.
    


Intervention name(s): Ready to Eat Cereal
Intervention type(s): Other
Intervention description(s): Cereal products available in retail stores
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Evaluation of the Allergenicity of AMPHADASE INJECTION (Hyaluronidase Injection USP)
Condition: Allergic Skin Reaction
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is designed to evaluate the allergenicity of Amphadase® in healthy volunteers
      using an intradermal skin test.
    


Intervention name(s): Hyaluronidase; Histamine; Saline
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Subjects received intradermal injections of 0.02 mL Amphadase® (hyaluronidase 150 USP units/mL) at two random sites on their forearms.; Subjects received one intradermal injection of 0.02 mL Histatrol® (histamine base 0.1 mg/mL) at one random sites on their forearms.; Subjects received one intradermal injection of 0.02 mL saline at one random site on their forearm.
Other intervention name(s): Amphadase®; Histatrol®
Intervention MeSH terms: Histamine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Screening
Keywords: hyaluronidase; enzymes with tissue spreading activity; allergic reaction; intradermal skin testing
Curcuminoids for the Treatment of Chronic Psoriasis Vulgaris
Condition: Psoriasis
MeSH terms: Psoriasis
Study type: Interventional
Phase: Phase 2

Summary: 
      Turmeric (Curcuma Longa) is member of the ginger family and is best known for its culinary
      use as the major of component of curry powder. The volatile of oils (called curcuminoids) of
      the turmeric root, however, have anti-inflammatory actions which make them promising
      candidates for the treatment of psoriasis. For example, curcumin has been shown to improve
      psoriasis in experiments using in vitro models. Turmeric has been shown to have minimal side
      effects in doses up to 12 grams per day. The purpose of this study is to determine the safety
      and to estimate the efficacy of oral Curcuminoid C3 Complex® in patients with chronic
      psoriasis vulgaris.
    

Detailed description: 
      This study is no longer recruiting.
    

Intervention name(s): Curcuminoids C3 Complex®
Intervention type(s): Drug
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Alternative Medicine; Psoriasis; Turmeric; Curcumin; Dermatology
mFLOT Chemotherapy as First-line Treatment in GC
Condition: Gastric Cancer
MeSH terms: Stomach Neoplasms
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      A single center phase 1b/2 trail to identified suitable dosage and its efficacy of modified
      FLOT regime in Chinese gastric cancer patients. This trial is designed to identified
      recommended phase II dose (RP2D) of modified FLOT in Chinese patients, and to evaluate the
      efficacy of modified FLOT regime as first-line for advanced or metastatic gastric cancer.

      This trial is in 2 stages: the first stage will establish the maximum tolerated dose (MTD)
      and RP2D of docetaxel and oxaliplatin in FLOT regime. In the second stage, the efficacy of
      modified FLOT will be assessed by response rate.
    

Detailed description: 
      The RP2D of FLOT regime will be established with a standard 3+3 design, starting with the
      dose of 40mg/m2 docetaxel (dose level 1) and 65mg/m2 oxaliplatin (dose level 1). The plan of
      dose escalation will be found in following table. Chemotherapy will be administered
      two-weekly (maximum 12 cycles) until progression of disease, intolerable toxicity or withdraw
      of patients.
    

Intervention name(s): docetaxel, oxaliplatin, 5-FU, leucovorin
Intervention type(s): Drug
Intervention description(s): This is a single-arm study with all patients receiving mFLOT chemotherapy.
Intervention MeSH terms: Leucovorin; Docetaxel; Oxaliplatin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
White Matter in Pediatric Bipolar Disorder: A DTI Study
Condition: Bipolar Disorder
MeSH terms: Bipolar Disorder
Study type: Observational

Summary: 
      Fourteen subjects with bipolar disorder and 14 matching healthy controls, aged 6-13, will
      receive a magnetic resonance imaging (MRI) scan on a 3 Tesla scanner. They will also have a
      clinical interview, including the KSADS-PL. All subjects must be right-handed.
    

Detailed description: 
      We propose to investigate the connectivity of white matter tracts using diffusion tensor
      imaging (DTI) in children with very early onset bipolar disorder (BPD). We hypothesize that
      the connectivity between the prefrontal cortex and the temporal lobe and parietal lobe and
      limbic structures will be abnormal, indicating white matter and gray matter deficits in early
      onset BPD. We also hypothesize that the superior lateral fasciculus cingulum bundle and the
      inferior lateral fasciculus will have decreased fractional anisotropy in very early onset BPD
      relative to healthy controls.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Bipolar Disorder
      
Keywords: bipolar disorder; magnetic resonance imaging; white matter; diffusion tensor imaging; children; adolescents
Effect of Phosphate Binders on FGF-23 With Concurrent Calcitriol
Condition: Chronic Kidney Disease Stage 3
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic
Study type: Interventional
Phase: Phase 4

Summary: 
      Chronic kidney disease (CKD) is an established risk factor for cardiovascular morbidity and
      mortality, as shown by common manifestations of left ventricular hypertrophy (LVH) and
      arterial calcifications in CKD patients. Fibroblast growth factor-23(FGF-23) is a recently
      identified phosphaturic hormone that has been reported to be associated with the development
      of secondary hyperparathyroidism, cardiovascular morbidity, mortality, CKD progression.

      While vitamin D is the mainstay therapy in CKD mineral bone disease (CKD-MBD), increased
      FGF-23 levels have been reported with vitamin D administration. The purpose of this study was
      to investigate the effect of calcium carbonate when used in conjunction with calcitriol on
      FGF-23.
    


Intervention name(s): Calcitriol; Calcium Carbonate
Intervention type(s): Drug; Drug
Intervention MeSH terms: Calcitriol; Calcium Carbonate; Calcium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: FGF-23; Calcitriol; Calcium carbonate; CKD Stage 3
A Study of Ramosetron Plus DX, Dexamethasone, Compared to Granisetron Plus DX for the Prevention of Vomiting and Nausea
Condition: Vomiting; Nausea
MeSH terms: Nausea; Vomiting
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to compare the efficacy and safety of ramosetron plus
      dexamethasone injection with granisetron plus dexamethasone injection for the prevention of
      chemotherapy-induced vomiting and nausea.
    


Intervention name(s): Ramosetron; Granisetron
Intervention type(s): Drug; Drug
Intervention description(s): IV, concomitant administration with dexamethasone; IV, concomitant administration with dexamethasone
Intervention MeSH terms: Granisetron; Ramosetron
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Serotonin antagonists; Randomized controlled trial; Combination drug therapy; Double-blind method
Oral Health Related Quality of Life and Peri-implant Condition in Single Implant Overdenture
Condition: Quality of Life; Implant
Study type: Interventional

Summary: 
      Comparing the quality of life and periimplant condition around a single implant retained
      mandibular overdenture in two groups one will have a ball attachment and the other is having
      a (CM-LOC) one.
    

Detailed description: 
      Single implant retained mandibular overdenture is considered an economic and simple treatment
      modality for edentulous subjects. Resin matrix (CM LOC) is one of the low profile attachments
      which represent a promising retention values with subsequent improvement in chewing ability
      and in turns enhance patient quality of life.Oral health impact profile for edentulous
      patient (OHIP-EDENT) is more specific to edentulous subjects.

      Peri-implant soft tissue health (bleeding, inflammation, etc...) is a valuable marker to
      implant success. The study will record different attachment influenced-tissue response and
      its relation to implant success and oral health related quality of life (OHRQOL)
    

Intervention name(s): CM LOC attachment; ball attachment
Intervention type(s): Device; Device
Intervention description(s): CM LOC attachment; Ball attachment
Other intervention name(s): resin matrix attachment; metallic ball attachment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
PS-341 and Doxorubicin in Treating Patients With Advanced Solid Tumors
Condition: Unspecified Adult Solid Tumor, Protocol Specific
MeSH terms: Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
      they stop growing or die.

      PURPOSE: Phase I trial to study the effectiveness of combining PS-341 and doxorubicin in
      treating patients who have advanced solid tumors.
    

Detailed description: 
      OBJECTIVES:

        -  Determine the maximum tolerated dose of PS-341 in combination with doxorubicin in
           patients with advanced solid tumors.

        -  Determine the qualitative and quantitative toxic effects of this regimen in these
           patients.

        -  Determine the antitumor activity of this regimen in these patients.

      OUTLINE: This is a dose-escalation study of PS-341.

      Patients receive PS-341 IV over 3-5 seconds on days 1, 4, 8, and 11; and doxorubicin IV on
      over 3-5 minutes on days 1 and 8. Treatment repeats every 21 days in the absence of disease
      progression or unacceptable toxicity.

      Cohorts of 3-6 patients receive escalating doses of PS-341 until the maximum tolerated dose
      (MTD) is determined. The MTD is defined as the dose preceding that at which at least 2 of 3
      or 2 of 6 patients experience dose-limiting toxicity.

      PROJECTED ACCRUAL: A total of 3-31 patients will be accrued for this study within 1 year.
    

Intervention name(s): bortezomib; doxorubicin hydrochloride
Intervention type(s): Drug; Drug
Intervention MeSH terms: Doxorubicin; Liposomal doxorubicin; Bortezomib
Primary purpose: Treatment
Keywords: unspecified adult solid tumor, protocol specific