bioihbjkbjnl/mcl2 huggingface dataset:
The Role of Platelet Surface α2β1 Integrin Expression as a Risk Factor in Thrombotic and/or Bleeding Complications
Condition: Genetic Polymorphism
MeSH terms: Hemorrhage
Study type: Observational

Summary: 
      This study will begin to define these critical determinants for patients undergoing
      procedures in the hybrid interventional cardiology/cardiac surgery suite. In future studies,
      the data obtained from this study will be used to prospectively stratify patients in terms of
      bleeding verses thrombotic risk to design studies to optimize anticoagulation and
      anti-platelet therapies in the hybrid setting.
    

Detailed description: 
      The aim of this study is to test the association of DNA polymorphisms linked to the level of
      αβ1 integrin expression on platelets with clinical outcome in terms of bleeding or thrombotic
      complications. The association of polymorphisms in other genes such as GPVI, PAR-1, and
      COX-2, as well as PLA ½ status, will also be examined and considered in the context of other
      factors such as medications including IIb/IIIa inhibitors, anticoagulants, type of procedure,
      obesity smoking status, etc.

      Lower levels of platelet surface expression of the α2β1 integrin are associated with an
      increased risk of bleeding complications following hybrid procedures, especially when the low
      level of integrin expression is associated with other risk factors that may exacerbate
      bleeding such as vigorous anti-coagulation, aggressive anti-platelet therapy and other
      genetic risk factors that contribute to a hemorrhagic phenotype. Conversely, higher level
      expression of the α2β1 integrin is likely associated with a greater tendency to thrombotic
      complication that is again modified by other coexisting risk factors.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        patients undergoing procedures in a hybrid interventional cardiology/cardiac surgery suite
      
Biospecimen description: 
      Whole Blood
    
Keywords: Genetic Polymorphism; Integrin alpha2beta1; Phenotype
Entamoeba Gingivalis and Periodontal Disease
Condition: Periodontal Diseases
MeSH terms: Periodontal Diseases
Study type: Observational [Patient Registry]

Summary: 
      This current study aims to clarify the relationship between the occurrence of Entamoeba
      gingivalis infection and the specter of gingivitis & chronic periodontitis among Egyptian
      patients in comparison to healthy volunteers as a control group.
    

Detailed description: 
      Three groups will be included in the current study. 40 Plaque samples will be collected from
      gingivitis patients (group 1), 40 from chronic periodontitis patients (group 2) plus 40
      samples from healthy volunteers (group 3). Diagnosis of parasitic stages will rely on direct
      microscopic detection using permanent stains, Trichrome stain and haematoxylin and eosin
      stain in addition to direct wet mount examination.
    

Intervention name(s): Plaque Samples
Intervention type(s): Other
Intervention description(s): After carefully drying of the selected site and isolation by cotton roll, plaque samples will be collected by sweeping movement of the probe at gingival crevices of the tooth aspect with pervious inclusion criteria for obtaining of the plaque sample. Samples will be immediately dipped in sterile Eppendorf tubes containing PVA.
Observational model: Case-Control
Time perspective: Other
Sampling method: Probability Sample
Study population: 
        Gingivitis & Chronic periodontitis patients will be selected from the outpatients Clinic,
        Department of Oral Medicine, Periodontology and Diagnosis, Faculty of Dentistry, Fayoum
        University. Clinical examination for all patients will be performed including the following
        periodontal parameters: plaque index, gingival index, probing depth, and clinical
        attachment level. These measurements will be recorded by a single calibrated expert
        examiner at six sites for all teeth (mesiobuccal, mesiolingual, midbuccal, distobuccal,
        distolingual, and midlingual). PI is assessed by measuring the presence or absence of
        supragingival biofilm with a sweeping movement of the probe around the surfaces of all
        teeth
Transitioning Open Heart Surgery Patients From Insulin Infusions to Detemir
Condition: Diabetes Mellitus
Study type: Interventional
Phase: Phase 4

Summary: 
      In this study we will determine the proper method for transitioning patients from a
      continuous insulin infusion to periodic injections of a newer long-acting insulin called
      detemir (Levemir).
    

Detailed description: 
      High sugar (glucose) is common after surgery, even in patients who do not have diabetes. High
      glucose contributes to severe hospital complications and even death. Insulin infusions appear
      to reduce this risk, but are generally only continued for a few days after surgery. In this
      study, we will determine the proper method for transitioning patients from a continuous
      insulin infusion to periodic injections of a newer long-acting insulin called detemir
      (Levemir). 90 patients who have undergone recent open heart surgery and are requiring an
      insulin infusion will be enrolled. They will be randomly assigned to one of three doses of
      detemir, which consists of 50%, 65%, or 80% of the total daily insulin infusion requirement
      in the fasting state. Subjects will also receive identical mealtime coverage according to the
      amount of carbohydrate (glucose) that is ingested. It is expected that the high dose group
      will achieve superior glycemic control without excessive hypoglycemia.
    

Intervention name(s): Detemir; Detemir; Detemir
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Detemir dosed at 50% of calculated basal insulin infusion requirements; Detemir dosed at 65% of calculated basal insulin infusion requirements; Detemir dosed at 80% of calculated basal insulin infusion requirements
Other intervention name(s): Levemir
Intervention MeSH terms: Insulin Detemir
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: diabetes; hyperglycemia; open heart surgery; cardiothoracic surgery; detemir; insulin infusion; intravenous insulin
The Effect of Ingesting or Rinsing Sucrose and Sucralose on Self-control, Cognitive Performance, and Blood Glucose
Condition: Self-control; Cognitive Performance; Blood Glucose Response
Study type: Interventional

Summary: 
      The purpose of this study is to examine the effects of ingesting or mouth rinsing a sucrose
      (carbohydrate) versus a sucralose (carbohydrate-free) drink on self control, cognitive
      performance, and blood glucose level.
    


Intervention name(s): Ingestion of solution; Rinising of solution
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Participants will ingest the solution; Participants rinse the solution in the oral cavity
Intervention MeSH terms: Pharmaceutical Solutions
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
A Study of Aleglitazar in Combination With Ibuprofen in Healthy Volunteers
Condition: Healthy Volunteer
Study type: Interventional
Phase: Phase 1

Summary: 
      This randomized, double-blind, placebo-controlled, parallel group study will investigate the
      safety and tolerability, and the effect of aleglitazar in combination with ibuprofen on renal
      function, renin-angiotensin system and pharmacokinetics in healthy volunteers. Volunteers
      will be randomized to receive daily doses of aleglitazar or placebo in combination with
      ibuprofen. The anticipated time on study drug is 5 weeks.
    


Intervention name(s): aleglitazar; placebo; ibuprofen
Intervention type(s): Drug; Drug; Drug
Intervention description(s): repeated daily doses; repeated daily doses; repeated daily doses
Intervention MeSH terms: Ibuprofen
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Pharmacokinetic Drug Interactions Between Single and Concomitant Administrations of Amlodipine, Losartan, and Hydrochlorothiazide in Subjects With (Pre)Hypertension
Condition: Essential Hypertension
MeSH terms: Hypertension; Essential Hypertension
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is aimed to evaluate the pharmacokinetics and the drug-drug interaction among
      anti-hypertension drugs-amlodipine, losartan, and hydrochlorothiazide. This pilot study
      provides useful information to develop a new fixed dose combination drug.
    


Intervention name(s): multiple dose, crossover study between single and concomitant administrations of amlodipine, losartan, and hydrochlorothiazide
Intervention type(s): Drug
Intervention description(s): amlodipine 10 mg for 9 days , losartan 100 mg for 9 days, hydrochlorothiazide (HCTZ) 25 mg for 9 days and combination of amlodipine 10 mg, losartan 100 mg and hydrochlorothiazide (HCTZ) 25 mg for 9 days, 4 way crossover study
Intervention MeSH terms: Losartan; Amlodipine; Hydrochlorothiazide
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Effect of Inguinal Hernia Repair on Uroflowmetric Parameteres
Condition: Inguinal Hernia; Urinary Retention; Lower Urinary Tract Symptoms
MeSH terms: Urinary Retention; Hernia; Hernia, Inguinal; Lower Urinary Tract Symptoms
Study type: Interventional

Summary: 
      Post operative acute urinary retension or voiding dysfunction are complications after
      inguinal hernia repair and they cause a great deal of discomfort and stress to patients.
      Furthermore, they can also increase hospital costs by increasing hospital stay, and by
      growing the need for outpatient appointments after an elective surgical procedure. Some
      studies recommend prophylactic alpha blockers to minimizing these adverse effects.

      Investigators aimed to determine the changes of uroflowmetric values for male patients
      following elective inguinal hernia repair.
    

Detailed description: 
      Inguinal hernia repair is a common procedure performed in general surgery, with an annual
      rate of 28 per 100,000 of the population in the USA. The incidence of post operative
      inability voiding in males following open or laparoscopic inguinal hernia repair varies from
      3 to 25%. Evaluating risk factors to reduce the occurence of this complications after one of
      the most commonly performed surgery by general surgeons could help reduce that high rate of
      that complication. Although some authors recommend prophylactic alpha blockers, there is no
      consensus on whether these can decrease rate of urinary retention or voiding dysfunction in
      male patients.

      In current study, investigators aimed to determinate the uroflowmetric parametric changes of
      patients after elective inguinal hernia repair.
    

Intervention name(s): Inguinal hernia repair
Intervention type(s): Procedure
Intervention description(s): Lichtenstein procedure or laparoscopic method (Total extraperitoneal) inguinal hernia repair
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: The patients who underwent elective open or laparoscopic inguinal hernia repair were treated by a single general surgeon.
Masking: Single (Participant)
Primary purpose: Diagnostic
Keywords: complication; uroflowmetry
Efficacy and Safety Study of QAW039 in the Treatment of Patients With Moderate to Severe Atopic Dermatitis.
Condition: Atopic Dermatitis
MeSH terms: Dermatitis, Atopic; Dermatitis; Eczema
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine whether QAW039 is safe and has beneficial effects
      in people who have moderate to severe atopic dermatitis (AD).
    


Intervention name(s): QAW039; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Capsules; Capsules
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Atopic eczema; Skin Diseases
The Effect of Aroma Massage on Constipation
Condition: Constipation
MeSH terms: Constipation
Study type: Interventional

Summary: 
      Advancing age arising changes in health status and systems adversely affect the quality of
      life of the elderly and the elderly face many complex health problems. Constipation is one of
      the common problems in the elderly. Therefore, The aim of this study is to examine effects of
      aromatherapy massage on constipation in the elderly.
    

Detailed description: 
      Old age is a physiological period of life in which various changes take place, meaning that
      the elderly must be given special consideration as a group with regard to health care.
      Advancing age arising changes in health status and systems adversely affect the quality of
      life of the elderly and the elderly face many complex health problems. Constipation is one of
      the common problems in the elderly. Insufficient liquid intake, insufficient or unsuitable
      diet, decreased mobility, the side effects of medication, underlying diseases, and rectal
      sensory-motor dysfunction are among the causes of constipation in the elderly. Constipation
      is a preventable and treatable problem, which if left untreated can cause physical and
      associated psychological problems such as back and waist pain, rectal pressure, loss of
      appetite, confusion, incontinence, nausea and vomiting, urinary dysfunction, fissure, rectal
      prolapse, hemorrhoids, intestinal obstruction, and syncope. Constipation can be managed using
      pharmacological methods, such as laxatives, enemas, suppositories, along with
      nonpharmacological procedures, such as changes in nutritional habits, fluid intake,
      education, activities to develop healthy intestinal habits, exercise, massage, aroma massage,
      biofeedback, stress management and acupuncture.
    

Intervention name(s): Aroma massage
Intervention type(s): Other
Intervention description(s): The older adult participants in the experimental group were applied aroma massage through gentle movements with slight pressure for 15 min a day, five days a week for three weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Supportive Care
Keywords: aroma massage; constipation; elderly; nursing
Dyslipidemia in Cardiovascular Disease
Condition: Dyslipidemia
MeSH terms: Cardiovascular Diseases; Dyslipidemias
Study type: Interventional
Phase: Phase 4

Summary: 
      A multi-center, randomized, double-blinded equivalence clinical trial to evaluate efficacy
      and safety of LipiLou 20 mg versus Lipitor 20 mg in hypercholesterolemic patients with higher
      risk cardiovascular disease in Korea.
    


Intervention name(s): Atorvastatin (Lipilou); Atorvastatin (Lipitor)
Intervention type(s): Drug; Drug
Intervention description(s): treatment of dyslipidemia administration : PO, qod; treatment of dyslipidemia administration : PO, qod
Other intervention name(s): Lipitor
Intervention MeSH terms: Atorvastatin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Dyslipidemia
Bent-arm Throw and Tennis Performance
Condition: Tennis Serve Performance
Study type: Interventional

Summary: 
      The objective of this study is to explore the relaitonship betwenn bent-arm throw and tennis
      serve performance.

      Young players (9-12 years) will be assessed at the beginning of the season and at mid-season
      to measure the accuracy, the speed and the gesture of tennis serve. During a mid-season, they
      will have to perform a bent-arm throw warm-up program 5 minutes before each training session
      to increase their ability to throw.
    


Intervention name(s): Bent-arm throw exercises
Intervention type(s): Other
Intervention description(s): The participants will have to perform bent-arm throw exercises 5 minutes before each training session
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Total Xenoestrogen Body Burden in Relation to Mammographic Density, a Marker of Breast Cancer Rlisk
Condition: Breast Cancer Risk
MeSH terms: Breast Neoplasms
Study type: Observational

Summary: 
      Mammographic density is sensitive to estorgen exposure and constitutes a strong intermediate
      maker of breast cancer risk. We hypothesize that women with higher serum xenoestrogen levels
      will have greater mammographic density.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Subjects recruited from screening mammography population
      
Biospecimen description: 
      Serum Xenoestrogen
    
Keywords: Breast; Estrogens; Mammography
A PHASE 1, OPEN-LABEL, CROSS-OVER, FIXED SEQUENCE STUDY TO EVALUATE THE EFFECT OF MULTIPLE DOSES OF DS-1971A ON THE SINGLE DOSE PHARMACOKINETICS OF PROBE SUBSTRATES FOR CYP2B6, CYP2C8, CYP2C9, CYP2C19 AND CYP3A4 ENZYMES IN HEALTHY MALE AND FEMALE SUBJECTS
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This is an open-label, cross-over, fixed-sequence study. All subjects will receive the same
      treatment in two study periods. The study is designed to test whether DS-1971a has any effect
      on the activity of various enzymes involved in the metabolism of medicines, using test
      medications. These will be given without and then with DS-1971a to see if DS-1971a has any
      effect on the blood levels of the test medicines.
    


Intervention name(s): DS-1971a; midazolam hydrochloride; Omeprazole; Pioglitazone hydrochloride; Buproprion; Tolbutamide
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): 200mg tablet; 2.5mg oromucosal liquid; 20mg gastro-resistant capsule; 15mg tablet; 150mg Prolonged release tablet; 500mg tablet
Intervention MeSH terms: Pioglitazone; Tolbutamide; DS-1971a; Midazolam; Omeprazole
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Pharmacokinetics
The Activation on Prefrontal Cortex With Acupuncture and Moxibustion for Major Depressive Disorder: A Study of Functional Near Infrared Spectroscopy
Condition: Depressive Disorder, Major
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 2

Summary: 
      This study evaluates the activation on prefrontal cortex with acupuncture and moxibustion for
      major depressive disorder.Half of participants will receive the treatment of acupuncture and
      moxibustion, while the other participants will receive the fluoxetine.
    

Detailed description: 
      Major depressive disorder (MDD) is a psychiatric condition with high morbidity, disability,
      suicide and recurrence rate and become the hot and difficult topics in the medical study.
      Given the unsatisfactory response rates of many FDA-approved antidepressants, acupuncture is
      increasingly considered an important alternative therapy. A large number of clinical trials
      have confirmed that acupuncture is a generally safe, effective, and well-tolerated therapy
      for depression, but for MDD, the acupuncture clinical trials were only reported out of China.
      According to the clinical symptoms in patients with MDD, the chief TCM patterns are liver qi
      constraint and heart yang insufficiency, and the secondary TCM patterns are blood stasis, qi
      and blood deficiency. So we propose to combine acupuncture with moxibustion and select Baihui
      (DU20), shenting(DU24), Neiguan (PC6), Hegu (LI4), Taichong (LV3), Zusanli(ST36), Zhongwan
      (RN 12) and Gaunyuan (RN4) to Soothe the Liver, regulating the heart, warm the yang qi, boost
      qi and invigorate blood for MDD. We hypothesize that the acupuncture's antidepressant effect
      is based on the neural network reconstructing mechanism through studying the cerebral cortex
      function, hippocampal synaptic plasticity, Neurons electrophysiological change. We will
      employ multi-disciplinary methods in neuropsychology, neuroimaging, computer science, and
      electrophysiology to explore the important mechanism underlying acupuncture and moxibustion
      treating MDD.
    

Intervention name(s): acupuncture and moxibustion; Fluoxetine
Intervention type(s): Other; Drug
Other intervention name(s): Prozac
Intervention MeSH terms: Fluoxetine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Acupuncture; Moxibustion; Major Depressive Disorder; MDD; Neural Network Reconstruction; cerebral function; functional near infrared spectroscopy (fNIRS) imaging
Growth Hormone and Insulin Growth Factor 1 Deficiencies in Children/Adolescents Following Traumatic Brain Injury: The Impact on Growth and Neuropsychological Development
Condition: Traumatic Brain Injury
MeSH terms: Brain Injuries; Brain Injuries, Traumatic; Wounds and Injuries
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The purpose of this study is to look at the relationship between growth hormones, and
      recovery from a TBI - traumatic brain injury. It is believed that a TBI may interfere with
      the body's ability to produce growth hormones. These hormones may be needed by the body for
      growth, mental development and sexual maturation.
    


Intervention name(s): Growth Hormone Replacement
Intervention type(s): Drug
Intervention MeSH terms: Hormones
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Growth Hormone replacement; subject 8 to 21; moderate to severe traumatic brain injury; growth hormone deficient
Evaluation of the Middle Turbinate Implant for Affixing the Middle Turbinate to the Nasal Septum
Condition: Sinusitis
MeSH terms: Sinusitis
Study type: Interventional

Summary: 
      The purpose of this study is to determine the functional performance of the Middle Turbinate
      Implant (MTI). The MTI will be used in all patients requiring endoscopic sinus surgery in
      which the Principal Investigator determines clinical relevance.
    


Intervention name(s): Middle Turbinate Implant
Intervention type(s): Device
Intervention description(s): Middle Turbinate Implant placement at time of surgery and follow ups.
Other intervention name(s): MTI
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: turbinate; implant; sinus surgery; Turbinates