bioihbjkbjnl/mcl2 huggingface dataset:
Evaluation of CO2 Rebreathing During Exercise With the Increasing Ventilation Assisted by NIV With a Dual-limb Circuit
Condition: Chronic Obstructive Pulmonary Disease
MeSH terms: Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Study type: Interventional

Summary: 
      Ventilated by a single-limb tubing with PEV caused CO2 rebreathing to COPD patients during
      exercise with the increasing ventilation. The aim of this study was to evaluate whether CO2
      rebreathing could be avoided with the use of the dual-limb circuit, to provide a theoretical
      basis of more rational clinical application of NIV in the setting of increasing
      ventilation(eg, after exercise).
    

Detailed description: 
      Exercise training is a key component of pulmonary rehabilitation. It has shown signifcant
      improvements in both exercise tolerance and quality of life in patients with COPD. The
      intensity of exercise training is of great importance to yield a true physiologic effect.
      However, in patients with severe COPD, exertional dyspnea and leg fatigue make it impossible
      for the patient to maintain intensity of training for enough time to achieve a physiologic
      training effect. NIV has been reported to be used as support for exercise to improve exercise
      tolerance and respiratory performances in patients with mild-to-severe COPD with inconsistent
      results. Evidence from previous studies have suggested that NIV with a single-limb circuit
      with Whisper Swivel II expiratory valve or Plateau exhalation valve assisted during exercise
      in patients with COPD caused CO2 rebreathing. CO2 rebreathing may have a negative impact on
      efficacy. Previous studies have proved that exercise tolerance was improved ventilated by NIV
      with a dual-limb circuit. In theory, NIV with a dual-limb circuit consists of one inhalation
      limb that introduces air into the patient's airways and one exhalation limb that leads
      exhaled gas outside of the airways, there is no risk of rebreathing. However, there was no
      report on whether there's no risk of rebreathing in COPD patients ventilated during exercise
      by a dual-limb circuit. Therefore, the aim of the study was to determine whether there was no
      CO2 rebreathing occurred assisted with NIV with dual-limb circuit in patients with stable
      severe COPD after exercise with exertional dyspnea.
    

Intervention name(s): dual-limb NIV
Intervention type(s): Device
Intervention description(s): dual-limb NIV was served with servo i ventilator
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Investigation of Secreted Phosphoproteins and PiP3 (Phosphoinositolphospat 3) in Sputum
Condition: Healthy; Smoking, Cigarette
Study type: Interventional

Summary: 
      The aim of this study is to validate two new biomarkers in sputum samples. These are PiP3
      (phosphoinositolphospat ) and phosphor proteins, representing important proteins within
      inflammatory situations of the lung.
    

Detailed description: 
      Within the study, sputum samples will be collected at 3 repetitive occasions in a 3 week
      interval of the different donors.

      The objective is to assess for biomarker specificity and reproducibility in the two groups
      (smokers and non-smokers). The methods for measurement shall be validated by repetitive
      measurement of the sputum samples, i.e. comparison of multiple measurements of the same
      sample and comparison of different samples from the same donor.
    

Intervention name(s): Induced sputum procedure
Intervention type(s): Other
Intervention description(s): induced sputum is a sputum specimen produced for diagnostic tests by aerosol administration of a hypertonic saline solution.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Determination of the Efficacy of Slendertone® Face to Tone the Muscles of the Face and Reduce the Signs of Facial Aging
Condition: Facial Muscle Toning
MeSH terms: Facies
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study was to determine the efficacy of Slendertone® Face™, to tone the
      muscles of the face and reduce the signs of facial aging among the following characteristics:
      radiance, tone, lift, firmness and complexion, following a 12-week programme of facial muscle
      toning. Slendertone® Face is a neuromuscular electrical stimulation (NMES) device which
      features a headset unit designed for application to the face for facial toning. The purpose
      of the headset is to locate and support a pair of stimulation electrodes on each side of the
      face, over the facial nerve just anterior to the ear.
    

Detailed description: 
      The trial was planned with 100 healthy female volunteers between 25 and 55 years of age.

      Treated group: Face device 20 minutes per day, 5 days per week for 12 weeks.

      Control group: No NMES.

      Both Groups: No changes to usual beauty routine, or use of beauty products with an anti-aging
      claim, or changes to usual diet or exercise habits over the course of the 12 week study
      period.

      Assessments:

      Ultrasound measurements of the zygomaticus major muscle were planned at Baseline, and at the
      end of Weeks 6 and 12.

      Psychometric questionnaires at Baseline, end of Weeks 6 and 12.
    

Intervention name(s): Slendertone Face
Intervention type(s): Device
Intervention description(s): Slendertone Face 20 minutes/day, 5 days/week for 12 weeks.
Other intervention name(s): Slendertone Face, Type 371; Class II, Powered Muscle Stimulator
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Facial toning; Facial lift; Improve facial complexion; Improve facial tone; Improve radiance of the face; Reduce signs of facial aging; firming, lift, tone face
Arthrodesis Versus Extra-articular Plate Fixation in Lisfranc Injury
Condition: Lisfranc Injuries
MeSH terms: Wounds and Injuries
Study type: Interventional

Summary: 
      The purpose of this study is to compare arthrodesis of the first TMT-joint to extraarticular
      bridge plate fixation of the same joint in acute Lisfranc injuries.
    

Detailed description: 
      We want to compare arthrodesis of TMT 1 to temporary bridge plating of TMT 1 in acute
      Lisfranc injuries where at least tarsometatarsal joints 1-3 are involved.

      We preform arthrodesis of TMT 2 and 3 in both groups.
    

Intervention name(s): Temporary extraarticular plate fixation; Primary arthrodesis; Primary arthrodesis TMT 2 and 3
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): Arm 1: Primary arthrodesis TMT 1 Arm 2: Temporary extraarticular plate fixation TMT 1; Primary arthrodesis; Primary arthrodesis TMT 2 and 3 when instability is present
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Changes of Cerebral Glucose Metabolism After 12 Weeks of Paroxetine Treatment in Panic Disorder
Condition: Panic Disorder
MeSH terms: Panic Disorder
Study type: Interventional
Phase: Phase 4

Summary: 
      Panic disorder is one of the most prevalent and disabling psychiatric disorders. Brain
      regions such as amygdala, hippocampus, periaqueductal gray (PAG), locus coeruleus,
      parahippocampal gyrus, frontal cortex, and thalamus has been reported to be related with the
      pathophysiology and treatment outcome in panic disorder. Paroxetine has been used as primary
      agent for treatment of panic disorder but there is little information on how paroxetine
      affects the brain function in patients with panic disorder.

      The specific aim of this study is to examine the differences in brain activity between
      responders and nonresponders and to determine the predictor of paroxetine treatment in
      patients with panic disorder in terms of brain activity.
    


Intervention name(s): Paxil CR
Intervention type(s): Drug
Intervention description(s): 12 week treatment of Paxil(20-40mg)
Intervention MeSH terms: Paroxetine
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: panic disorder; paroxetine; PET
Advanced Electronic Population Health and Personal Health Record Tools to Improve Once Lifetime Hepatitis C Screening
Condition: Hepatitis C
MeSH terms: Hepatitis A; Hepatitis C; Hepatitis
Study type: Interventional

Summary: 
      This study involves randomizing patients due for once in a lifetime Hepatitis C screening
      based on Center for Disease Control and Prevention and United States Preventative Services
      Task Force guidelines in one of three primary care clinics within the MetroHealth System to
      bulk messaging and bulk ordering for HCV antibody vs usual care (routine alerting).
    

Detailed description: 
      All patients had to have an active personal health record account at the time of being
      randomized.

      Patients had to have been seen by their primary care provider in the last 6 months to be
      eligible and therefore had a "missed opportunity" for Hepatitis C screening.

      Control group received "usual care" which in our system included alert (health maintenance
      reminder) to the primary care provider at the time of the visit and passive alert in their
      personal health record (i.e. an alert if they log into their personal health record and look
      for reminders for preventative care that it due/overdue).

      Intervention group received same care as control group plus automatic ordering of the
      hepatitis C screening test and active electronic letter their personal health record that
      they were due for hepatitis C screening, what hepatitis C is, what the testing and if
      positive, treatment could involve, and instruction to go to one of the laboratories in the
      healthcare system to have their blood drawn if they were interested in the testing.
    

Intervention name(s): Bulk ordering and bulk messaging; Routine alerting
Intervention type(s): Other; Other
Intervention description(s): Patients in the intervention group had the hepatitis screening test ordered for them in bulk and then a bulk message sent to them through the personal health record describing hepatitis C and how they could be tested.; Passive alerting to providers (during face-to-face encounters using the electronic health record) and to patient (when they review preventative screening recommendations through their personal health record).
Intervention MeSH terms: Caffeine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Investigator)
Primary purpose: Screening
Keywords: preventative screening; electronic health records; personal health records; population health tools
Bioequivalency Study of Fenofibrate 160mg Tablets Under Fasting Conditions
Condition: Healthy
Study type: Interventional

Summary: 
      The study was conducted as an open label, balanced, randomised, two-treatment, two-period,
      two-sequence, single-dose crossover bioavailability study on fenofibrate formulations
      comparing fenofibrate 160 mg tablets of Ranbaxy Laboratories with Tricor 160 mg tablets in
      healthy, adult, human subjects under fasting conditions.
    

Detailed description: 
      This was an open-label, randomized, single-dose, 2-way crossover, relative bioavailability
      study performed on 40 healthy adult male subjects.

      As per protocol, enough healthy, adult, human subjects were to be enrolled in the study to
      allow the dosing of 40 subjects in the first period. 40 subjects were enrolled and a total of
      37 subjects completed both the periods of study.
    

Intervention name(s): fenofibrate 160 mg tablets
Intervention type(s): Drug
Intervention MeSH terms: Fenofibrate
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: bioequivalence fenofibrate tablets
Cholecalciferol Supplementation on Disease Activity, Fatigue and Bone Mass on Juvenile Systemic Lupus Erythematosus.
Condition: Systemic Lupus Erythematosus
MeSH terms: Lupus Erythematosus, Systemic; Fatigue
Study type: Interventional

Summary: 
      The potential role of vitamin D on disease susceptibility, activity and severity has been
      considered for several autoimmune rheumatologic diseases include systemic lupus erythematosus
      (SLE) . Although, there are few studies of vitamin D supplementation in SLE patients,
      especially in Juvenile Onset Systemic Lupus Erythematosus (JoSLE).

      The objective of this study is to evaluate the effect of vitamin D supplementation
      (cholecalciferol 50.000 international units (IU)/week for 24 weeks) on disease activity
      (clinical and laboratory parameters), fatigue and bone mass.
    

Detailed description: 
      This is a study 24-week, two arm, double blinded randomized clinical trial to evaluate the
      effects of high-dose vitamin D3 supplementation compared with placebo, on activity disease,
      fatigue and bone mass.

      Sixty JoSLE patients will be randomized to receive placebo or vitamin D3 (50.000 IU/week) for
      24weeks. The patients return to visits in week 12 and week 24 for evaluation. Study will
      record clinical history, drugs in use, disease activity, and bone mass parameters.
    

Intervention name(s): Cholecalciferol; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): All patients and physicians were blinded to group assignment and treatment allocation. The first group received oral cholecalciferol of 50,000 IU/week and for 6 months. All subjects were evaluated at baseline and after the end of supplementation for clinical and laboratory parameters.; The second group received identical placebo tablets for 6 months. All subjects were evaluated at baseline and after the end of supplementation for clinical and laboratory parameters.
Other intervention name(s): Vitamin D3; No other names
Intervention MeSH terms: Vitamin D; Cholecalciferol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Lupus; Juvenile; Cholecalciferol; Disease activity; Bone Mass; Fatigue; Safety
Influence of Emotions on Decision-making in Parkinson's Disease
Condition: Parkinson Disease
MeSH terms: Parkinson Disease
Study type: Interventional

Summary: 
      Parkinson's disease mainly affects the dopaminergic neurons of the Substancia nigra, which
      project on the striatum. Neuronal death within this structure leads to a decrease in dopamine
      levels. Dopamine is a neurotransmitter essential to the proper functioning of the basal
      ganglia highly involved in the control of voluntary and involuntary movements.

      It also leads to cognitive and behavioral changes. Among these changes, the investigators
      will mainly remember the idea of the emergence of difficulties to make the right decisions,
      for example at the financial, medical .... This disruption would be the result of executive
      dysfunction. By definition, executive functions allow us to evaluate, plan and organize our
      actions to achieve a goal.
    

Detailed description: 
      Some research shows that positive emotional states are associated with greater
      self-confidence, greater optimism, and better regulation of our decision-making. The goal is
      to test whether positive emotional induction could improve decision-making in Parkinson's
      disease.

      Listening to music would decrease anxiety levels and increase self-esteem levels. Who says
      Parkinson says dopamine deficiency and so the investigators can think that the investigators
      can help patients by inducing a positive emotion through musical stimulation.

      All participants will be subject to emotional induction. They will be divided into two
      different conditions: either they will be induced in a positive state, or they will be
      maintained in a neutral state. For this, video clips (positive or neutral) containing music
      will be presented. Immediately after the presentation of the video, participants will have to
      perform the Iowa Gambling Task test. This is a sequential task to evaluate decision-making
      capabilities.
    

Intervention name(s): cognitive examination; viewing of video; Iowa Gambling Task
Intervention type(s): Other; Other; Other
Intervention description(s): mini mental test of Parkinson, Hospital Anxiety and Depression Scale, 5 words by Dubois, fast test frontal assessment, Trail Making Test; viewing during 5 minutes scale of differential emotions and Positive and Negative Affect Scale; Test of Iowa Gambling Task
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: influence of emotions; positif emotional induction; decision making; Iowa Gambling Task
Comparing Acceptance and Commitment Therapy (ACT) and Cognitive Therapy (CT) for Test Anxiety
Condition: Anxiety
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      This study proposes to compare the effectiveness of an acceptance-based intervention and a
      cognitive control-based intervention for coping with test anxiety in nursing students during
      the HESI (Health Education Systems, Inc.) examination.

      Subjects will be randomized to receive either the CT or the ACT condition. In both
      conditions, subjects will receive an education on test anxiety to inform them about what test
      anxiety is and why it occurs. Then, the different conditions will receive the respective
      treatment of either CT or ACT. The study is considered minimum risk because the nursing
      students will only be exposed to an amount of anxiety that is typical of their testing
      experience. Both conditions will meet three times, with each session lasting approximately
      one and a half hours. The purpose of the treatment is to provide subjects with tools to help
      them cope with their test anxiety.
    


Intervention name(s): CT; ACT
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Cognitive Therapy Intervention: Subjects receiving the CT strategies will be taught to restructure their negative thoughts to make them more positive, based on the concept that thoughts are linked to their problems with test anxiety because beliefs can cause strong powerful emotions and behaviors. Subjects will be taught not to blame their environments for emotional and behavioral responses, and they will be shown how to change their beliefs in order to affect their emotions and their behaviors.; Acceptance-and-Commitment Therapy Intervention: Subjects receiving the ACT strategies will be taught to defuse from their anxiety (or recognize that their thoughts are just thoughts). They will be taught to accept their anxiety and to learn to live with anxiety. Subjects will be told that while they cannot control the occurrence of their thoughts, they can control whether or not they choose to view them as separate from the self versus part of the self.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: test anxiety
Effect of Exendin-(9-39) on Fasting Adaptation and Protein Sensitivity
Condition: Congenital Hyperinsulinism
MeSH terms: Congenital Hyperinsulinism; Nesidioblastosis; Hyperinsulinism
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The purpose of this study is to examine the effects of exendin-(9-39) on fasting blood
      glucose and protein induced hypoglycemia on subjects with Congenital Hyperinsulinism. Funding
      Source - FDA Office of Orphan Products Development (OODP).
    

Detailed description: 
      This is a placebo controlled study with randomized crossover design to evaluate the effect of
      the glucagon-like peptide-1 (GLP-1) receptor antagonist, exendin-(9-39), on fasting blood
      glucose levels, protein-induced hypoglycemia, and fasting tolerance of subjects with
      congenital hyperinsulinism due to mutations in the ATP- sensitive potassium channel (KATP)
      channel.
    

Intervention name(s): Exendin-(9-39); placebo
Intervention type(s): Drug; Drug
Intervention description(s): 100-500pmol/kg/min; placebo (0.9% NaCl)
Other intervention name(s): (0.9% NaCl)
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: In a random crossover design, subjects were assigned to either intervention (6 hour infusion of exendin( 9-39) at a dose range of 100-500pmol/kg/min) or vehicle (6hr infusion of 0.9%NaCl)
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Hyperinsulinism; Hypoglycemia; KATP channel
Evaluation of Monocyte Volume Distribution Width (MDW) for Early Detection of Sepsis
Condition: Sepsis; Severe Infection
MeSH terms: Sepsis; Toxemia
Study type: Observational

Summary: 
      The measurement of monocyte volume width distribution (MDW) is intended for use with adult
      patients presenting to the emergency department (ED), where a CBC with Differential has been
      ordered, as an aid in the early detection of patients with or developing sepsis. The study
      will establish the clinical performance of MDW for detection of sepsis in the ED.
    

Detailed description: 
      A prospective multi-center study to establish the clinical utility of the measurement of
      monocyte volume width distribution, a cell population parameter of the CBC-Differential, on
      the Beckman Coulter Unicel DxH analyzers. The study will validate the cut-off for the early
      detection of sepsis in an adult emergency room population where the standard of care included
      a CBC with Differential and will evaluate the diagnostic performance of the parameter.
    

Intervention name(s): CBC-Diff Monocyte volume width distribution (MDW)
Intervention type(s): Diagnostic Test
Intervention description(s): MDW measurement used to detect sepsis. Results will not be used to manage patients
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        All adult patients with suspicion who present to ED and for whom CBC with Diff is performed
        upon ED presentation.