bioihbjkbjnl/mcl2 huggingface dataset:
Evaluation of Novel Optical Smartphone Application for Blood Pressure Measurements in Critically Ill Patients
Condition: Hypotension
MeSH terms: Hypotension
Study type: Observational

Summary: 
      Evaluation of a novel mobile application designed to estimate blood pressure
      (systolic-diastolic and mean arterial pressure) based on collected optical signals on
      patient's finger treated in intensive care unit patients
    

Detailed description: 
      The purpose of the study is to compare the blood pressure values measured by a novel mobile
      phone application ( camera of the smartphone will be obstructed by the patient's right index)
      and the values measured by reference method used (the radial arterial line)

      All patients admitted in the intensive care unit at Erasme Hospital Brussels, Belgium will be
      recruited and if they have an arterial line for at least two days

      The OptiBP Application is a mobile application installed on a mobile phone which is a
      non-invasive data-logger intended to acquire physiological data from patients. By applying
      the patient's finger on a smartphone's camera, a movie is generated and transformed into
      values of diastolic, mean and systolic blood pressure.

      Three measures will be taken (spaced by one minute) with both methods each hour for 5 hours
      and this will be done for 2 days.

      The patient's blood pressure will be measured in parallel with the mobile application and
      with the reference equipment (arterial line).

      Then, the values obtained by the two methods will be compared to confirm the reliability of
      the data obtained with the novel mobile application.

      The goal is therefore to compare blood pressure values as obtained by the analysis of the
      data recorded by the OptiBP Mobile Application, against simultaneous measurements provided by
      the arterial line (gold standard)
    

Intervention name(s): OPti BP measurements
Intervention type(s): Device
Intervention description(s): measurement of blood pressure with the new smartphone App ( OPTIBP)
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        All intensive care unit patients with an arterial catheter for at least 48 hours
Sperm Quality in Consecutive Sperm Samples After 4-7 Days and 2 Hours of Sexual Abstinence
Condition: Semen Quality
Study type: Interventional

Summary: 
      The main purpose of the study is to assess to which degree a series of sperm parameters known
      to be associated with fertilization and implantation potential in artificial reproductive
      technology (ART) differ in consecutive sperm samples produced after 2-7 days and 2 hours of
      sexual abstinence in males from couples referring for ART treatment.
    


Intervention name(s): 2-7 days of Sexual abstinence; 2 hours of sexual abstinence
Intervention type(s): Other; Other
Intervention description(s): 2-7 days of Sexual abstinence; 2 hours of sexual abstinence
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Semen quality; Sexual Abstinence; sperm motility; DNA fragmentation
Using a Novel Functional MRI Technique to Evaluate for Neurotoxicity
Condition: Central Nervous System Lymphoma
MeSH terms: Lymphoma
Study type: Observational

Summary: 
      The purpose of this study is to test resting state functional Magnetic Resonance Imaging
      (rsfMRI) scans to see if rsfMRI scans are better than the standard task based fMRI scans at
      diagnosing or monitoring central nervous system lymphoma.
    


Intervention name(s): Resting State fMRI (rsfMRI); Auditory Attention and Executive Functions Test; Memory Test; Motor Speed Test; Self Reported Quality of Life Questionnaire
Intervention type(s): Diagnostic Test; Other; Other; Other; Other
Intervention description(s): rsfMRI before receiving High-dose chemotherapy with autologous stem cell transplantation/HDC-ASCT (pre-HDC-ASCT), at approximately 3 months (+/- 2 weeks) after HDC-ASCT (early post-HDC-ASCT) and approximately 6months (+/- 2 weeks) after HDC-ASCT (late post-HDC-ASCT).; Trail Making Test (Parts A & B): Part A is a timed test of visual scanning and graphomotor speed; AT: 3 minutes. Part B is a timed measure of set-shifting; Administration Time (AT): 5 minutes. Test-retest reliabilities=0.64-0.94.
Brief Test of Attention-BTA assesses auditory working memory; AT: 10 minutes. Test-re-test reliability=0.70.
Controlled Oral Word Association Test-COWAT is a timed measure of phonemic verbal fluency. It requires the subject to generate as many words as possible, beginning with a given letter of the alphabet (i.e., F, A, and S). The subject is allowed 60 seconds per letter, and the resultant score is the total number of words produced. Test-retest reliability=0.88. AT: 5 minutes.; The Hopkins Verbal Learning Test-Revised (HVLT-R): The HVLT-R is a test of verbal learning and memory.; Grooved Pegboard Test (GPT)-Dominant Hand and Non-Dominant Hand. It is a timed test of manual dexterity, in which the time to completion is scored separately for each hand.; The Functional Assessment of Cancer Therapy-Brain Cancer (FACT-BR Version 4) consists of 46 questions with five domains assessing physical well-being, social/family well-being, emotional well-being, functional well being, additional concerns. The neuropsychological and QOL assessments will be performed by a neuropsychologist or by a trained RSA under the neuropsychologist's direct supervision.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Potential research subjects will be identified by a member of the patient's treatment team,
        listed protocol investigators, or Neuroradiology research team at Memorial Sloan Kettering
        Cancer Center (MSKCC).
      
Keywords: resting state functional Magnetic Resonance Imaging; rsfMRI; 17-403
The Effects of Body Mass İndex On İntraabdominal Pressure And Regional Cerebral Oxygen Saturation İn Prone Position
Condition: Cerebral Hypoxia During and/or Resulting From A Procedure
MeSH terms: Hypoxia, Brain; Hypoxia
Study type: Observational

Summary: 
      A total of 40 ASA (American Society of Anesthesiology) physical status I-III who underwent
      lumbar disc hernia repair for one or two levels were included in this prospective study. A
      standard anesthesia protocol was performed in all patients. Routine intraoperative monitoring
      consisted of electrocardiography, automatic noninvasive arterial blood pressure, pulse
      oximetry, capnography, and cerebral tissue oxygen saturation through NIRS.Patients'
      demographics such as age, gender, height, weight, BMI, smoking status and pre-existing
      medical conditions were recorded.The patients were allocated equally to two groups according
      to BMI as Group I: BMI ≥30kg/m2,Group II <30 kg/m2.
    

Detailed description: 
      Routine intraoperative monitoring consisted of electrocardiography, automatic noninvasive
      arterial blood pressure, pulse oximetry, capnography, and cerebral tissue oxygen saturation
      through NIRS.Frontal lobe oxygenation was monitored continuously and recorded every 5
      minutes.Before positioning patients on the operating table, a Foley catheter was placed. IAP
      was measured in the following positions in all patients: 1) in the supine position after
      intubation 2) in the prone position before the skin incision.All patients were placed into
      the prone position on the silicone pads after general anesthesia.Before statistical analysis,
      the 40 patients were allocated equally to two groups according to the World Health
      Organization Guideline of BMI: Group I: BMI ≥30kg/m2, Group II <30 kg/m2
    

Observational model: Case-Control
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        40 ASA physical status I - III patients undergoing lumbar disc hernia repair for two or
        less levels. The ethical committee approval for the study was taken from the Abdurrahman
        Yurtaslan Oncology Training and Research Hospital (2014-2182). The informed consent was
        obtained for all the patients that were included in the study
      
Keywords: cerebral oxygenation, prone position, obesity
Safety of and Immune Response to an HIV Vaccine (SF-2 gp120) With or Without MTP-PE/MF59 Adjuvant
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      Part A: To compare the safety and immunogenicity of two dose levels of gp120 (CHO) in MF59
      emulsion alone or with MTP-PE/MF59 adjuvant, administered at 0, 1, and 6 months.

      Part B: To evaluate the safety and immunogenicity of gp120 in MF59 when administered in five
      monthly injections.

      One experimental AIDS vaccine is the gp120 vaccine. The HIV envelope glycoprotein 120 is
      manufactured through recombinant DNA technology and used as an immunogen. Antibodies directed
      against gp120 can neutralize HIV-1, and gp120 can also stimulate certain types of
      cell-mediated immune responses. Because many immunogens, including candidate HIV vaccines,
      may evoke relatively weak immune responses, the use of adjuvants, or substances that augment
      immune responses to vaccines, is of interest. MTP-PE/MF59, composed of the immunomodulator
      MTP-PE combined with MF59 emulsion, appears to be a promising adjuvant and has been selected
      for studies with the gp120 vaccine.
    

Detailed description: 
      One experimental AIDS vaccine is the gp120 vaccine. The HIV envelope glycoprotein 120 is
      manufactured through recombinant DNA technology and used as an immunogen. Antibodies directed
      against gp120 can neutralize HIV-1, and gp120 can also stimulate certain types of
      cell-mediated immune responses. Because many immunogens, including candidate HIV vaccines,
      may evoke relatively weak immune responses, the use of adjuvants, or substances that augment
      immune responses to vaccines, is of interest. MTP-PE/MF59, composed of the immunomodulator
      MTP-PE combined with MF59 emulsion, appears to be a promising adjuvant and has been selected
      for studies with the gp120 vaccine.

      In Part A, 32 volunteers (eight on each of four treatment arms) are randomized to receive one
      of two doses (15 or 50 mcg) of gp120 vaccine with either MTP-PE/MF59 adjuvant emulsion or
      MF59 emulsion alone. The volunteers receive three IM injections at 0, 1, and 6 months. In
      Part B, 16 female volunteers (eight on each of two treatment arms) are randomized to receive
      either MF59 emulsion alone (placebo) or MF59 emulsion plus gp120 vaccine (50 mcg). Volunteers
      receive five IM injections at monthly intervals.
    

Intervention name(s): rgp120/HIV-1 SF-2; MTP-PE/MF59
Intervention type(s): Biological; Biological
Masking: Double
Primary purpose: Prevention
Keywords: Vaccines, Synthetic; Adjuvants, Immunologic; HIV Envelope Protein gp120; AIDS Vaccines; HIV Seronegativity; HIV Preventive Vaccine
Integrated Chiropractic and Acupuncture Treatment for Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is being conducted to compare the effectiveness of integrated chiropractic and
      acupuncture care for the management of low back pain.
    

Detailed description: 
      This study is being conducted at the Southern California University of Health Sciences.
      Eligible subjects will be randomized to one of three treatment groups: chiropractic care
      alone, acupuncture care alone, and chiropractic and acupuncture care combined.

      Subjects will be treated on pragmatic basis for 60 days and then followed up for an
      additional 60 days. All examinations and treatments will be provided free of charge. The
      expected benefits for the participants are decreased pain and improved function.
    

Intervention name(s): Chiropractic; Acupuncture
Intervention type(s): Other; Other
Intervention description(s): Spinal manipulation and active and passive therapy.; Acupuncture needling, moxa, Tui Na and cupping.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Low back pain; Chiropractic; Acupuncture; Integrated care
Stress Prevention at Work: Intervention Efficacy and Implementation Process Evaluation
Condition: Stress, Psychological
MeSH terms: Stress, Psychological
Study type: Interventional

Summary: 
      The Stress prevention at work (SPA) project intends to evaluate the method named Productivity
      Measurement and Enhancement System (ProMES) as a stress preventive approach among health care
      employees.
    

Detailed description: 
      Stress-related illnesses are today together with musculoskeletal disorders the predominant
      cause of production loss and absenteeism. The risks of developing stress-related mental
      illness is today well established, however, it is less studied how this can be successfully
      treated or prevented in workplaces through interventions.

      The SPA project intends to evaluate the method the Productivity Measurement and Enhancement
      System (ProMES). The method is mainly evaluated for production improvement, but there are
      indications that it also has stress-reducing effect on working groups. The method gives
      employees within health care opportunities to participate actively in productivity-enhancing
      measures. The employees, along with their immediate supervisors, identify and prioritize
      responsive and desirable results in all of the activities important dimensions. International
      studies have shown that participation (participation) has positive effects on employee
      performance and attitudes.

      The aim of this study is to test whether efforts in targeting the organization and work
      environment can reduce stress and prevent stress-related ill health in the workplace. Primary
      outcomes of the study are tense work i.e. imbalance between demand and control and other
      primary indicators of stress, such as sleep and recovery.

      The hypothesis in study 1 is that productivity enhancing workplace interventions based on a
      participative approach also increases employees' sense of control and control over their own
      work. This in turn means that the method also could be used to reduce the occurrence of tense
      work and thus affect / reduce the stress-related illness.
    

Intervention name(s): ProMES
Intervention type(s): Behavioral
Intervention description(s): Productivity measurement and enhancement system (ProMES) is a participatory intervention for productivity enhancement. Core strategies of this method could be addressing known work stressors such as absence of influence and control, insufficient interaction with coworkers, unclear and conflicting tasks, insufficient participation in decision-making and insufficient feedback
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: work related stress
Circular pOlyethylene Drape in preVention of Surgical Site infEction: A Randomized Controlled Trial
Condition: Surgical Wound Infection
MeSH terms: Infections; Communicable Diseases; Surgical Wound Infection; Wound Infection; Surgical Wound
Study type: Interventional

Summary: 
      This study is to evaluate the effectiveness of the plastic ring wound retractor to reduce the
      rate of surgical site infection in patients who undergo open abdomen surgery for
      gastrointestinal tract.
    

Detailed description: 
      Participants who are determined to undergo open abdomen surgery will be screening for the
      eligibility first. If eligible and agreed to participate, each participant will be assigned
      to either the experimental group or control group based on the electronic randomization. The
      experimental group will use the plastic ring wound retractor, while the control group will
      use a conventional surgical pad for wound protection method. Each participant will be blind
      to the randomization result because he/she will be under general anesthesia. Once the surgery
      is finished, the patient will be assessed on the surgical wound at postoperative day 1, 7,
      14, 30. Two groups will be compared for the surgical wound infection rate.
    

Intervention name(s): use of plastic ring wound retractor
Intervention type(s): Device
Intervention description(s): the experimental arm will use the plastic ring wound retractor for wound protection.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The experimental group will be using the plastic wound retractor, while the control group will use a conventional surgical pad for wound protection.
Masking: Single (Participant)
Primary purpose: Prevention
Evaluation of the Ease of Use, Preference, and Safety of EutropinPen Inj.
Condition: Short Stature, Idiopathic; Infant, Small for Gestational Age; Growth Hormone Deficiency; Chronic Renal Failure; Turner Syndrome
MeSH terms: Dwarfism; Kidney Failure, Chronic; Turner Syndrome; Gonadal Dysgenesis
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to assess the ease of use, preference, and safety after 8 weeks
      subcutaneous administration of EutropinPen Inj. in patients pretreated with recombinant human
      growth hormone by reusable device.
    


Intervention name(s): Somatropin
Intervention type(s): Drug
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effects of Personalized Training at Home Combining Endurance and Resistance in Patients Suffering From Marfan Syndrome
Condition: Marfan Syndrome
MeSH terms: Marfan Syndrome; Arachnodactyly; Syndrome
Study type: Interventional

Summary: 
      Marfan syndrome (MS) is an autosomal dominant genetic disorder caused by a mutation in the
      fibrillin-1 gene (FBN1) encoding the protein fibrillin-1. Fibrillin is the main component of
      microfibrils, elements found in all of the body's tissues, and this pathology is
      characterized by the multitude of its clinical manifestations. These patients may develop
      aneurysms in the aortic root and one of the main factors of morbidity in patients with MS is
      aortic dissection. Prevention mainly involves preventive aortic surgery. However, the
      repercussions are global and can affect the functioning of other tissues such as skeletal
      muscle tissue, bone tissue, lung tissue and the eyes. The association of skeletal (scoliosis,
      hyperlaxity), muscular and ocular disorders is clearly associated with an impairment in the
      quality of life. These disorders are associated with pain and disability which affect
      professional activity, leisure and family life.

      Physical activity could represent a relevant alternative for these patients. A recent animal
      study suggests that moderate training is beneficial.
    

Detailed description: 
      The main objective is to show that the quality of life of patients with Marfan syndrome can
      be improved by personalized training at home. The goal is to be able to offer new non-drug
      management based on physical activity to these patients.

      Improved quality of life; Improvement of muscle strength by a muscle strengthening protocol;
      Improvement of cardiovascular function parameters. Regular coaching throughout the study.

        1. / Assessment of muscular capacities

        2. / Assessment of cardiovascular and respiratory capacities

        3. / Response to psychometric questionnaires

        4. / Participation in a training circuit (training protocol)
    

Intervention name(s): Endurance training; Muscle building training
Intervention type(s): Other; Other
Intervention description(s): Aerobic circuit training; Muscle strengthening circuit training
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 3 groups of physical training intervention compared with control group
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Physical training
Effect of a 4-week Post-exercise Sauna Bathing on Targeted Gut Microbiota
Condition: Healthy Males
Study type: Interventional

Summary: 
      Body temperature fluctuations induced by acute exercise bouts may influence the intestinal
      barrier with related effects on epithelial permeability, immune responses, and release of
      metabolites produced by the gut microbiota.
    

Detailed description: 
      Untrained males aged 22±1.5 years were randomly assigned to exercise training (ET) with or
      without post-exercise sauna treatments (S). Participants in the group ET+S (n=8) exercised 60
      minutes, 3 times per week, on a bicycle ergometer followed by a 30-minute dry Finish sauna
      treatment. The control group (ET, n=7) engaged in the same exercise training program without
      the sauna treatments. Blood and stool samples were collected before and after the 4-week
      training program. Blood samples were analysed for the concentration of high-sensitivity
      C-reactive protein (hsCRP) and complete blood counts. Stool samples were analysed for pH,
      quantitative and qualitative measures of targeted bacteria and fungi, zonulin, and secretory
      immunoglobulin A. This study evaluated the effects of post-exercise sauna bathing in young
      men undergoing endurance training on gut bacteria inflammation and intestinal barrier
      function. Investigators hypothesized that sauna bathing applied immediately after a physical
      training session may impact homeostatic control of the gut microbiota and the function of the
      intestinal barrier.
    

Intervention name(s): The exercise 60 minutes, 3 times per week, on a bicycle ergometer followed by a 30-minute dry Finish sauna treatment.; The same exercise training program without the sauna treatments
Intervention type(s): Diagnostic Test; Diagnostic Test
Intervention description(s): Participants in the group ET+S (n=8) exercised 60 minutes, 3 times per week, on a bicycle ergometer followed by a 30-minute dry Finish sauna treatment.Blood and stool samples were collected before and after the 4-week training program.; The control group (ET, n=7) engaged in the same exercise training program without the sauna treatments. Blood and stool samples were collected before and after the 4-week training program.
Other intervention name(s): ET+S; ET
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: This study used a randomized, parallel group design. The participants were randomly assigned to exercise training (ET) without or with post-exercise sauna treatments (ET+S) by using a permuted blocks of block size 4. design with a computer.
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: gut microbiota, exercise, sauna bathing, intestinal barrier