Assessment and Training Visio Spatial Neglect in a Virtual Reality Environment
Condition: Hemispatial Neglect; Stroke
MeSH terms: Perceptual Disorders
Study type: Interventional

Summary: 
      There is a lack of effective rehabilitation methods for visio-spatial neglect (VSN). By using
      virtual technology, a new method (virtual reality, VR method) has been created which focuses
      on stimulating attention networks: top down scanning training in a 3D game, combined with
      intense visual, audio and tactile bottom-up stimulation, also including visuo-motor training.

      Objective. To evaluate clinical and functional improvement in stroke patients with VSN, as
      well as before and after training with the new VR method Method:- An intense visio spatial
      scanning training, enhanced by directed visual, audio and tactile stimulation cues and
      feedback, also including visio-motor activation was designed in a VR game. The in-house
      developed software was based on the Tetris game. The VR method consists of an interactive 3D
      environment: a desktop computer, a monitor, 3D glasses and a force feedback interface. 15
      patients with chronic (>6 months) visio spatial neglect was included due to right-sided
      ischemia. A VR neglect test battery including a Posner task were repeated three times during
      a 5 weeks baseline before the training started (to establish the chronic state) and again
      after 15 hours training (3x1 h for 5 weeks). Evaluation of a new method for training
      attention after stroke causing visio spatial neglect.

      The method has been designed for home rehabilitation and is well suited for a tele-medicine
      approach. It was built with standard components and is easy to manufacture at a low cost. The
      idea is to give access to effective training, to make it available at the stroke unit with
      the possibility for the patient to loan it it at discharge for home rehabilitation. The
      concept of an all in one, easy-to-use device for testing, training and outcome evaluation
      should be beneficial These preliminare results has been promising and indicates that the
      RehAtt™ method could become an further developed into an effective and stimulating
      intervention tool that would lower rehabilitation costs and reduce tiresome travelling to
      hospitals for training.
    

Detailed description: 
      A VR environment was used training (RehAtt) of post-stroke patients with neglect. Patients
      played the VR games three times a week for five weeks, totally 15 hours.

      A neglect test battery five neglect tests was repeated three times during a five week
      baseline to estabish a chronic state and reduce the test by test learning effect, then again
      after the 5 weeks training period. The main outcome results were thereafter obtained by
      comparing the 5 neglect tests: Star cancellation test, Baking Tray Task, Line Bisection,,
      Extinction and Posner task - unified index by SPSS Repeated Measurement ANOVA from the 3
      baseline visits to the results after intervention. The Catherine Bergego neglect scale was
      used to assess activities in daily life before and after intervention as well as after six
      months.

      Patients were included if they had a neglect that had persisted for more than six months
      after a right sided ishemic stroke.

      Neglect was diagnosed if one or more of the four neglect subtests of the VR test battery was
      below cut off (See below and Appendix for details).

      The exclusion criteria were severe visual impairment, severe medical illness, severe
      depression or cognitive dysfunction (MMSE ≤ 23 points). All patients received oral and
      written information with an informed and signed consent. The Umeå university ethics review
      board (IRB) approved the study (2010-266-31M).

      The hardware consists of a standard PC, a video graphics card, a sound card, headphones and a
      separate numeric keyboard to measure behavioural responses. In the VR test part, we used a
      19" CRT monitor and shutter glasses for stereoscopic vision. A 27" monitor and 3D vision
      glasses (Nvidia, Santa Clara, CA, USA) replaced them in the VR game part. A robotic pen
      (Phantom omni haptic device, Sensable technologies, Wilmington, USA) was used as a pointer
      using the right hand for assessment activities and the paretic left hand when playing the VR
      game for intervention.
    

Intervention name(s): VR-method
Intervention type(s): Other
Intervention description(s): Neglect rehabilitation by intense scanning training and multi sensory stimuli using Virtual Reality
Other intervention name(s): RehAtt
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Stroke, rehabilitation, spatial neglect