bioihbjkbjnl/mcl2 huggingface dataset:
A Follow-up Study on Total Endoscopic Thyroidectomy Bilateral Areola Approach
Condition: Quality of Life
Study type: Interventional

Summary: 
      Endoscopic thyroidectomy bilateral areola approach (ETBAA) is one of the most widely applied
      approach in China, meanwhile its safety and effectiveness has been broadly discussed since
      being introduced. However, these studies are generally with small sample size and short
      follow-up duration. The lack of long-term follow-up on oncological outcomes makes it
      inaccurate to evaluate the effectiveness of ETBAA versus OT. Thus, in this study, we
      evaluated long-term QoL and outcomes of patients with PTC underwent thyroidectomy via ETBAA
      versus OT.
    


Intervention name(s): Endoscopic Thyroidectomy Bilateral Areola Approach
Intervention type(s): Procedure
Intervention description(s): The endoscopic thyroidectomy achieves better cosmetic effects than open thyroidectomy, and is one of the most widely applied approach in China, meanwhile its safety and effectiveness has been broadly discussed since being introduced.
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Screening
Prevalence of Pulmonary Embolism in Patients With Dyspnea on Exertion (PEDIS)
Condition: Pulmonary Embolism
MeSH terms: Pulmonary Embolism; Dyspnea; Embolism
Study type: Observational

Summary: 
      PEDIS Study is an observational, cross-sectional, multicenter Italian study conducted in a
      consecutive series of patients who refer to the Emergency Departments (either spontaneously
      or sent by their attending physicians) for the recent (less than one months) development of
      exertional dyspnea.

      The general aim of the study is to assess the prevalence of PE in the overall population
      referring to the Emergency Departments without potential explanations for dyspnea
    

Detailed description: 
      PEDIS Study is an observational, cross-sectional, multicenter and no Profit Study.

      600 consecutive patients referring to the Emergency Departments of the participating centers
      because they have developed one or more episodes of exertional dyspnea since less than one
      month will be enrolled. All eligible patients will be interviewed and examined by trained
      study physicians. The presence of already known potential explanations for the dyspnea will
      be assessed. In addition, symptoms of the lower extremities will be elicited, as well as the
      presence of risk factors for venous thromboembolism (VTE).

      The presence or absence of pulmonary embolism will be assessed with the use of a validated
      algorithm based on pre-test clinical probability and D-dimer result. In patients in whom the
      pre-test clinical probability is low and the D-dimer result is negative, no further testing
      will be done, and PE will be considered excluded. In patients with high clinical probability,
      positive D-dimer result, or both, computed tomography (CT) pulmonary angiography will be
      performed

      The primary study objective is to evaluate Prevalence of PE in the overall population
    

Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        All consecutive patients who refer to the Emergency Departments of the participating
        centers will be eligible for the study provided they are older than 18 and younger than 75
        years, and have developed one or more episodes of exertional dyspnea since less than one
        month.
      
Keywords: Dyspnea; Pulmonary embolism
Long Term Study of Genotropin (Somatropin) for Short Children Born Small for Gestational Age (SGA)
Condition: Short Stature Born Small for Gestational Age (SGA)
MeSH terms: Dwarfism
Study type: Interventional
Phase: Phase 4

Summary: 
      To assess the long-term safety of Genotropin(somatropin) on Small for Gestational Age (SGA)
      without epiphyseal closing.
    


Intervention name(s): Genotropin (somatropin)
Intervention type(s): Drug
Intervention description(s): Genotropin(somatoropin) 12 mg, Genotropin(somatropin) will be given at a dose of 0.067 mg/kg/day or 0.033 mg/kg/day to all participating patients
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Genotropin(somatropin); SGA; Short Stature; Long-term; Safety
The Phenylephrine vs. Norepinephrine Infusion Undergoing Cesarean Section
Condition: Cesarean Section Complications
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      Compare 0.05 μg/kg/min Norepinephrine and 0.25 μg/kg/min phenylephrine effect on fetus and
      parturient during Cesarean Section
    

Detailed description: 
      1. Compare 0.05 μg/kg/min Norepinephrine and 0.25 μg/kg/min phenylephrine and control group
           effect on parturient hemodynamic change (systolic blood pressure SBP, diastolic blood
           pressure DBP,mean arterial pressure MAP,heart rate HR) and on LIDICO-rapid monitoring (
           stroke volume SV, systemic vascular resistance SVR, cardiac output CO) and peripheral
           vein (PV) blood gas during Cesarean Section.

        2. Compare 0.05 μg/kg/min Norepinephrine and 0.25 μg/kg/min phenylephrine and control group
           effect on fetus by blood gas of the umbilical vein (UV), umbilical artery (UA),
    

Intervention name(s): Norepinephrine; Phenylephrine; Ringer's Solution
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 0.05ug/kg/min Norepinephrine during Cesarean Section Operation; 0.25ug/kg/min phenylephrine during Cesarean Section Operation; 3 ml/kg/min of LR was administrated according to standard weight.
Other intervention name(s): Group 1 Elements; Group 2 Elements; Group 3 Elements
Intervention MeSH terms: Phenylephrine; Oxymetazoline; Norepinephrine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Cesarean delivery
Acceptability of Nutrient Supplements Among Women and Children in Bangladesh
Condition: Malnutrition
MeSH terms: Malnutrition
Study type: Interventional

Summary: 
      The study aims to confirm the acceptability of lipid-based nutrient supplements (LNS) for use
      as nutritional supplements for pregnant and lactating women (PLW) or infants and young
      children (IYC) and micronutrient powder (MNP) for use as nutritional supplements for infants
      and young children in Bangladesh.We hypothesized that at least 75 percent of the test dose of
      LNS and MNP offered to PLW and IYC will be consumed by them.
    

Detailed description: 
      The study will be conducted in three steps. Step 1 will be a test-feeding to compare the
      acceptability of each "version" of the LNS-child (LNS-child with cardamom flavor, LNS-child
      with no added flavor),LNS-PLW (LNS-PLW with cumin flavor, and LNS-PLW with no added flavor)
      and MNP to the others in terms of taste, smell and texture, as well as amount of the
      test-dose consumed. In Step 2, participants in the Phase 1 trial will receive a 2-week supply
      of one of the LNS products or MNP, which they will consume daily in their homes for 14 days
      under real-life conditions. In Step 3, focus group discussions will be held with participants
      to discuss different aspects of infant and child feeding and discuss best ways for the LNS or
      MNP product to be used in the context of Bangladesh.
    

Intervention name(s): Lipid-based nutrient supplement; Lipid-based nutrient supplement; Micronutrient powder
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Lipid-based nutrient supplement for pregnant and lactating women; Lipid-based nutrient supplement for infant and young children; Micronutrient powder for infant and young children
Other intervention name(s): LNS; LNS; MNP; Sprinkles
Intervention MeSH terms: Micronutrients; Trace Elements
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Keywords: Acceptability; Lipid-based nutrient supplements; Micronutrient powder; Malnutrition
Observational Study of Conjunctivitis in the Setting of DUPIXENT® Treatment for Atopic Dermatitis
Condition: Conjunctivitis; Atopic Dermatitis
MeSH terms: Conjunctivitis; Dermatitis, Atopic; Dermatitis; Eczema
Study type: Observational

Summary: 
      The primary objective of the study is to characterize the clinical phenotype(s) of
      DUPIXENT®-associated conjunctivitis events.

      The secondary objectives of the study are to characterize the course of conjunctivitis events
      during the observation period and collect and assess data on treatment for conjunctivitis
      events and its effectiveness.
    


Intervention name(s): dupilumab
Intervention type(s): Drug
Intervention description(s): No investigational agents will be provided to study patients, and no specific treatment is required during the study. DUPIXENT®-treated patients will receive DUPIXENT as standard of care for the treatment of their AD, as prescribed by their physician. However, continuous treatment with dupilumab for at least 8 weeks is required as a condition for eligibility.
Other intervention name(s): DUPIXENT®; SAR231893; REGN668
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        This study will enroll DUPIXENT®-treated patients with protocol-specified conjunctivitis
        events as well as reference patients with no clinical signs of conjunctivitis. Study
        participants will be recruited from patients being treated with DUPIXENT® for AD according
        to US Prescribing Information in the real-world setting, who develop conjunctivitis on
        treatment. These patients will be recruited with the help of a referral network of
        dermatologists and other physicians who treat patients with moderate-to-severe AD.
Peabody Developmental Motor Scale-2 in 0 - 24 Months in Turkey
Condition: Motor Development; Infant, Premature, Diseases
MeSH terms: Infant, Premature, Diseases
Study type: Observational

Summary: 
      This study is the determination of the Turkish version of the Peabody Developmental Motor
      Scale-2 and its Turkish validity reliability in infants age between 0 - 24 months and to
      spread its use for evaluation in early rehabilitation in our country.
    

Detailed description: 
      There are developments in the field of diagnosing children with a high risk of developmental
      disorders such as cerebral palsy (CP), mental problems and autism spectrum disorder in
      infancy . In particular, in infants experiencing the onset of extrauterine life in the
      neonatal intensive care unit, the combination of neonatal neuroimaging along with the
      assessment of general movements results in a highly accurate prediction of CP .A clinical
      tool often used in predictions is a neurological examination. Various standard variants are
      available, such as the Hammersmith Infant Neurological Examination (HINE), Alberta Infant
      Motor Scale (AIMS). PGMS-2 was developed by Folio and Fewell (2000) to determine the gross
      and fine motor development levels of children from birth to 71 months. The scale can be used
      for both children with healthy development and children with special needs. In the
      development of the Peabody Developmental Motor Scale (PGMS), which is the original version of
      PGMS-2 used in this study, a developmental structure was adopted instead of sticking to a
      certain theoretical perspective. PGMS is the first nationally standardized assessment tool
      that gives gross and fine motor scores separately in the United States of America (USA).This
      study is the determination of the Turkish version of the Peabody Developmental Motor Scale-2
      and its Turkish validity reliability in infants age between 0 - 24 months and to spread its
      use for evaluation in early rehabilitation in our country.
    

Intervention name(s): Peabody Developmental Motor Scale II (PDMS-2)
Intervention type(s): Diagnostic Test
Intervention description(s): is composed of six subtests (reflex, stationary, locomotion, object manipulation, grasping, and visual-motor integration) that measure inter-related abilities in early motor development. It was designed to assess gross and fine motor skills in children from birth through 5 years of age.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Infants between 0-24 months (adjusted age for premature infants will be calculated),who are
        followed as neurologically and developmentally at risk infants
      
Keywords: validity; Peabody Developmental Motor Scale II (PDMS-2); motor development
Influence of Stretching on Muscle Performance
Condition: Muscle Strength
Study type: Interventional
Phase: Phase 4

Summary: 
      The stretching is performed within sports to improve muscle performance and prevent muscle
      injury. However, recent studies are contradictory with common practice. Then raised the
      possibility that stretching before physical activity performed can decrease the muscle
      performance of healthy subjects.
    


Intervention name(s): Stretching
Intervention type(s): Other
Intervention description(s): Participants were divided into 3 groups. The group was referred to stretching 3 weekly for 4 consecutive weeks. Group B went 4 weeks without any intervention and held only one stretch before the re-test. And the group C performed passive knee mobilization. All participants were assessed for goniometry of the knee in flexion and extension and peak torque and power on the isokinetic dynamometer.
Other intervention name(s): peak of torque; performance; isokinetic dynamometer
Allocation: Randomized
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: Muscle Strength; Torque; Muscle Stretching Exercises; Range of Motion
Evaluation of Two Community Based Screening Strategies for Severe Acute Malnutrition in Children 6-59 Months in Mirria District, Niger
Condition: Malnutrition
MeSH terms: Malnutrition; Severe Acute Malnutrition; Child Nutrition Disorders
Study type: Interventional

Summary: 
      The objective of this study is to determine the efficacity of a community strategy for
      screening children 06-59 months old for Severe Acute Malnutrition (SAM) conducted by their
      mothers' compared with a community screening strategy conducted by Community Health Workers.
    


Intervention name(s): Screening by mothers; Active comparator: Screening by community health workers
Intervention type(s): Other; Other
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Screening; Malnutrition; Community Management of Acute Malnutrition
The Effect of Citrus Extract on Oxidative Stress
Condition: Elderly
Study type: Interventional

Summary: 
      This randomized, cross-over, double-blind, placebo-controlled trial aims to determine the
      effects of daily administration of citrus extract over a period of 4 weeks on markers of
      oxidative stress in elderly.
    


Intervention name(s): Citrus extract; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Citrus extract; Maltodextrin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Effect of rTMS of the Dorsolateral Prefrontal Cortex on Language Production in Healthy Participants
Condition: Language
Study type: Interventional

Summary: 
      The purpose of this study is to investigate the effects of repetitive transcranial magnetic
      stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) on language production.
    

Detailed description: 
      Background:

      Several studies investigating healthy or clinical populations have shown that (r)TMS applied
      over the dorsolateral prefrontal cortex (DLPFC) has an effect on language-related processes
      such as verbal working memory (Osaka et al., 2007), sentence comprehension (Cotelli et al.,
      2011) and language switching (Holtzheimer et al., 2005, Nardone et al., 2011).

      Clinical observations and neuroimaging studies seem to confirm the role of executive
      functions and frontal structures in language processing in monolingual and bilingual subjects
      (e.g. Fabbro et al., 2000, Abutalebi & Green 2007). However, only few studies investigated
      the effects of modulation of cognitive control-networks on lexical access.

      Aim and procedure:

      The study will investigate the role of the DLPFC and executive functioning in L1 and L2
      language processing. The core question is whether rTMS over the DLPFC will influence lexical
      access and language production.

      Each participant will take part in two sessions: 1. rTMS session 2. Sham rTMS session. After
      the application of rTMS/Sham rTMS, the participants will conduct two language tasks
      (translation, picture naming) and a non-verbal task, while the EEG is recorded.
    

Intervention name(s): rTMS; Sham rTMS
Intervention type(s): Device; Device
Intervention description(s): repetitive TMS (rTMS) can lead to temporary increases or decreases (depending on the protocol used) in excitability of the targeted area. This change in excitability has been shown to last beyond the duration of the stimulation.; Sham rTMS (or placebo rTMS) refers to a control condition in which no physiological effect on the targeted cortical region occurs.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: language; DLPFC; rTMS; Executive Functions
Effects of WBV in Children With Hemiparetic CP
Condition: Cerebral Palsy; Whole Body Vibration; Spastic Hemiplegia; Motor Performance
MeSH terms: Cerebral Palsy; Hemiplegia
Study type: Interventional

Summary: 
      The aim of this study was to investigate short and long-term effects of Whole Body Vibration
      therapy on spasticity and motor performance in children with hemiparetic cerebral palsy in
      addition to conventional physiotherapy.

      Twenty-six patients undergoing conventional physiotherapy in a private rehabilitation center
      were included in the study. Patients were randomized to treatment and control groups. Study
      was completed with a total of 22 cases (11 for each group). At the beginning of the study,
      cases were evaluated with Gross Motor Function Measure-88, LEGSys Spatio-Temporal Gait
      Analyzer, SportKAT550tm Portable Computerized Kinesthetic Balance Device and Modified
      Ashworth Scale. Cases in the treatment group were treated with Compex-Winplate for 8 weeks, 3
      times a week, 15 minutes a day in one session. All cases were reevaluated immediately after
      the treatment and 12 weeks after the treatment.
    


Intervention name(s): Whole-Body Vibration; Conventional Physiotherapy
Intervention type(s): Other; Other
Intervention description(s): Whole-Body Vibration Treatment for 3 sessions in a week for 8 weeks. Each sessions takes 15 minutes.; conventional physiotherapy for 2 sessions in a week for 8 weeks. Each sessions takes 45 minutes.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Cerebral Palsy; Spasticity; Motor Performance; Whole-Body Vibration; Conventional Physical Therapy
Remdesivir Efficacy In Management Of COVID-19 Patients
Condition: Covid19
MeSH terms: COVID-19
Study type: Interventional
Phase: Phase 3

Summary: 
      The study is open label randomized interventional phase 3 clinical trial. Patients with
      confirmed Covid-19 cases who was hospitalized in Two university isolation hospitals (Ain
      Shams University and Assiut University ) assigned hospitals for isolation.
    

Detailed description: 
      The study is open label randomized interventional phase 3 clinical trial. Patients with
      confirmed Covid-19 cases who was hospitalized in Two university isolation hospitals (Ain
      Shams University and Assiut University ) assigned hospitals for isolation.

      The included patients receive. Intervention group: Remdesivir loading dose of 200 mg
      intravenously followed by 100 mg/day intravenously for 5 to 10days + Methylprednisolone
      1-2mg/kg for 5-7 days Control group: standard of care without Remdesivir
    

Intervention name(s): Remdesivir; Standard of care_1; Standard of care_2
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Remdesivir loading dose of 200 mg intravenously followed by 100 mg/day intravenously for 5 to 10days; Hydroxycoloroquine 400mg twice on day 1 then 200mg tab twice 2-10 days; Methylprednisolone 1-2mg/kg for 5-7 days
Other intervention name(s): Veklury; Plaquenil; Steroid
Intervention MeSH terms: Remdesivir
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
PF-04634817 Renal Impairment Study
Condition: Renal Insufficiency
MeSH terms: Renal Insufficiency
Study type: Interventional
Phase: Phase 1

Summary: 
      Patients with renal impairment are the target population for PF-04634817. The clearance
      mechanism of this drug means that exposure may be increased in subjects with renal
      impairment. This study will investigate the effect of the drug in subjects with varying
      degrees of renal impairment. Pharmacokinetics, safety and toleration will be assessed.
    


Intervention name(s): PF-04634817; PF-04634817; PF-04634817; PF-04634817
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Single 50 mg dose administered to subjects with normal renal function (creatinine clearance greater than or equal to 90 ml/min); Single 50 mg dose administered to subjects with mild renal impairment (creatinine clearance 60-89 ml/min); Single 50 mg dose administered to subjects with moderate renal impairment (creatinine clearance 30-59 ml/min); Single 50 mg dose administered to subjects with severe renal impairment (creatinine clearance 15-29 ml/min)
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Subjects with Renal Impairment; healthy
A Study to Evaluate Safety and Pharmacokinetics/Pharmacodynamics of Sustained Release(SR) Exenatide
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the safety, pharmacokinetics, and pharmacodynamics
      of SR exenatide (PT302) in healthy subjects.
    


Intervention name(s): SR Exenatide (PT302); Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 0.5 mg, 1.0 mg, 2.0 mg and 4.0 mg dosage(dose escalation), single subcutaneous injection; Plcacebo of each doasage, single subcutanoeus injection
Intervention MeSH terms: Exenatide
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: diabetes; exenatide; SR exenatide; Peptron