Weight Loss Via Bariatric Surgery and Lifestyle Modification
Condition: Obesity; Weight Loss
MeSH terms: Body Weight; Weight Loss
Study type: Observational [Patient Registry]

Summary: 
      Gastric myoelectric, inflammatory, and hormonal responses, body compositional, energy
      expenditure, and metabolic changes during the development of obesity and the weight loss
      process are underinvestigated. This project studied the myoelectrical inflammatory and
      hormonal responses of the stomach, in addition to energy expenditure and body composition
      changes during weight loss via bariatric surgery and lifestyle intervention.
    

Detailed description: 
      Gastric myoelectric, inflammatory, and hormonal responses, body compositional, energy
      expenditure, and metabolic changes during the development of obesity and the weight loss
      process are underinvestigated. This project studied the myoelectrical, inflammatory, and
      hormonal responses of the stomach, in addition to energy expenditure and body composition
      changes during weight loss via bariatric surgery and lifestyle intervention.

      Methods: We recruited 79 participants who were assigned to three groups: bariatric surgery
      (BS group n=27), lifestyle intervention (LS group, n=22), and waitlist control (C group
      n=30). For all participants, electrogastrography, inflammatory cytokines, gastric hormones
      analysis, body composition analysis, energy expenditure, and dietary assessment were done at
      baseline and at 6 months.
    

Intervention name(s): Sleeve gastrectomy; Lifestyle intervention; Control
Intervention type(s): Procedure; Dietary Supplement; Other
Intervention description(s): laparoscopic sleeve gastrectomy was done under general anesthesia by the same surgeon in the SBAHC. Routine preoperative, and postoperative care (including early post-operative dietary management) were done. Baseline assessment was taken within the last week before the surgery during the preoperative preparation and the final assessment was recorded 6 months after the surgery date.; balanced 500 to 1000-calorie-deficit diet, personalized physical activity plan, and customized behavioral modification; No interventions were applied
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        A total of 79 participants were randomly assigned to three groups: bariatric surgery (BS
        group n=27), lifestyle intervention (LS group, n=22), and waitlist control (C group n=30).
        The participants in the three groups were similar in BMI (>35 kg/m2), age (18-40 years),
        and gender. Inclusion criteria included BMI > 35 kg/m2, and being free of any acute medical
        condition, malignancy, or psychiatric disorders. Participants taking weight-losing
        pharmacotherapy or who underwent previous bariatric surgery were excluded. For all
        participants, electrogastrography, inflammatory cytokines measurements, body composition
        analysis, dietary assessment, and indirect calorimetry (as described in objective 1) were
        done at baseline, and after 6 months.
      
Keywords: gastric myoelectric activity; Inflammatory; bariatric surgery; lifestyle intervention; weight loss; body composition