bioihbjkbjnl/mcl2 huggingface dataset:
Risk Factors for Pressure Ulcers
Condition: Pressure Ulcers
MeSH terms: Pressure Ulcer; Ulcer
Study type: Observational

Summary: 
      Development of pressure ulcer (PU) is complex and multifactorial. The association of a
      constituted PU and of clinical / biological major elements is demonstrated and justifies.
      Prevention of PU is an important health priority, one that requires clear identification of
      risk factors.
    


Intervention name(s): biochemical and molecular analysis
Intervention type(s): Other
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        This prospective study consisted of 100 patients were having at least one wound of pressure
        ulcer that met the following inclusion criteria. Who followed in many departments
        (emergency, orthopedic, physical medicine) of three University Regional hospitals of
        Tunisia (Farhat Hached and Sahloul Sousse, Fattouma Bourguiba Monastir) were evaluated
        prospectively.
      
Keywords: Difficult; environmental, microbial, immunological and genetic factors; significantly different
Acute and Chronic Effect of 250 mg Citicoline Consumption on Attention in Adults: A Randomized Trial
Condition: Attention
Study type: Interventional

Summary: 
      The primary study objectives are to test whether among a sample of healthy adults consuming:
      (1) a single capsule containing 250 mg citicoline has an effect on attentional performance 1,
      2 and 3 h post-dose compared to placebo (acute effect), and (2) capsule containing 250 mg
      citicoline per day for 28 consecutive days has an effect on attentional performance compared
      to placebo (chronic effect).
    


Intervention name(s): Active capsule; Placebo capsule
Intervention type(s): Dietary Supplement; Other
Intervention description(s): 1 capsule daily for 28 days; 1 capsule daily for 28 days
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: cognition; attention; attentional performance; CPT-III; citicoline
Prolonged Cardiopulmonary Bypass Time as a Predictive Factor for AGI After Heart Valve Replacement
Condition: Heart Valve Diseases
MeSH terms: Heart Valve Diseases
Study type: Observational

Summary: 
      In this retrospective study, the investigators will analyze the correlation between
      cardiopulmonary bypass (CPB) time and acute gastrointestinal injury (AGI), and the outcomes
      of AGI in patients undergoing heart valve replacement.
    

Detailed description: 
      Patients with heart valve diseases often have chronic cardiac insufficiency. Patients
      undergoing heart valve replacement with CPB are always complicated with gastrointestinal
      tract ischemia-reperfusion injury, which usually leads to AGI. AGI after cardiovascular
      surgery, especially in that use CPB, is associated with significant morbidity and an increase
      in peri-operative mortality. Prolonged CPB time could be predictive of AGI following heart
      valve replacement. This study is to analyze the correlation between CPB time and AGI, and the
      outcomes of AGI in patients undergoing heart valve replacement. The investigators hope that
      the benefits will include fewer patients becoming seriously postoperative AGI and mortality
      after cardiac surgery.
    

Intervention name(s): CPB time
Intervention type(s): Other
Intervention description(s): Cardiopulmonary bypass time
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Heart valve diseases
      
Keywords: Heart valve diseases; Gastrointestinal tract
Induced Suppression of Platelets Activity in Aneurysmal SAH Management (iSPASM)
Condition: Subarachnoid Hemorrhage, Aneurysmal
MeSH terms: Subarachnoid Hemorrhage; Hemorrhage
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This is a phase 1/2a, randomized, double blind, single-center study comparing standard care
      alone to standard care with Aggrastat in patients diagnosed with aneurysmal subarachnoid
      hemorrhage.
    

Detailed description: 
      This is a phase 1/2a, randomized, double blind, single-center study comparing standard care
      alone to standard care with Aggrastat in patients diagnosed with aneurysmal subarachnoid
      hemorrhage. The investigational plan is to explore the safety profile of Aggrastat
      administered continuously over 7 days, beginning at least 12 hours after a clinically
      indicated Endovascular Coil Embolization procedure.

      As a part of the study, qualifying subjects will undergo two MRI scans, one at baseline and
      again prior to discharge. A neurological exam and vital signs will be administered at
      baseline, daily during drug administration, and at follow-up visits. Additional assessments
      include administration of the following questionnaires: mRS score, IADL, and QOLIBRI-OS.
    

Intervention name(s): tirofiban hydrochloride (AGGRASTAT®); MRI; Neurological Exam; Questionnaires; Vital Signs; Standard of Care Treatment
Intervention type(s): Drug; Diagnostic Test; Diagnostic Test; Behavioral; Diagnostic Test; Other
Intervention description(s): Participants will have intravenous Aggrastat administered continuously over the course of 7 days in the setting of subarachnoid hemorrhage at least 12 hours post clinically indicated Endovascular Coil Embolization procedure.; Participants will undergo 2 MRIs administered within 24 hours post Coil Embolization procedure and prior to discharge to monitor for ischemic changes.; Neurological exams will be done at screening, randomization, days 2-7, discharge, 6 week, 6 month, and one year follow up visits.; Quality of Life in Brain Injury - Overall Scale (QOLIBRI-OS) and the Lawton Instrumental Activities of Daily Living (IADL) will be administered at 6 month and 1 year follow up visits.; Vital signs which include temperature, respiration rate, blood pressure and O2 stats will be done at screening, randomization, days 2-7, discharge, 6 week, 6 month, and one year follow up visits.; Participants will receive standard of care treatment and will not receive study drug.
Intervention MeSH terms: Tirofiban
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: All subjects will be randomized 2:1, Aggrastat vs. placebo.
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Emotional Disclosure in HIV
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Interventional

Summary: 
      The specific objective of this study are to examine whether or not a treatment aimed at
      emotional disclosure may have beneficial psychological, health and immune effects for HIV
      infected individuals. The goal of the current study is to test the efficacy of emotional
      disclosure through writing in patients with HIV infection. We will compare emotional
      disclosure through writing about traumatic experiences (experimental intervention) to a
      control intervention (writing about emotionally neutral topics). [Note that HIV RNA viral
      load, CD4 T cells, urinary cortisol, health related dysfunction, psychological distress, and
      medication adherence are the 6 primary outcome variables.
    


Intervention name(s): Trauma writing; Writing about daily events
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Complementary Therapies
Association Between Vitamin D Deficiency and Preeclampsia: A Case Control Study
Condition: Pre-Eclampsia
MeSH terms: Eclampsia; Pre-Eclampsia
Study type: Observational

Summary: 
      To find out if lower levels of vitamin D is more prevalent in preeclamptic women
    


Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        This study will be carried out on 90 pregnant women recruited at pre labour room at Ain
        Shams University Maternity Hospital. They will be divided into preeclamptic group and non
        preeclamptic group, 45 cases in each one
      
Biospecimen description: 
      serum
CIK Treatment for HCC Patient Underwent Radical Resection
Condition: Carcinoma, Hepatocellular
MeSH terms: Carcinoma; Carcinoma, Hepatocellular
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a randomized controlled study. About 200 patients with hepatocellular carcinoma who
      underwent radical resection will be included. The patients will be randomized to group A
      (receive CIK treatment) or group B (just regularly follow up) without any anti-cancer
      treatment after resection of HCC, and the randomize ratio will be 1:1.
    


Intervention name(s): Cytokine-Induced Killer Cells
Intervention type(s): Biological
Intervention description(s): Cytokine-Induced Killer Cells treatment for 4 cycles
Other intervention name(s): CIK
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Single-Dose Study of LY3471851 in Healthy Participants
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The main purpose of this study is to estimate how much LY3471851 gets into the blood stream
      and how long it takes the body to remove it when administered under the skin in healthy
      participants. The study will also evaluate the safety and tolerability of LY3471851. The
      study is expected to last up to 87 days for each participant.
    


Intervention name(s): LY3471851
Intervention type(s): Drug
Intervention description(s): Administered SC.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Efficacy of Muscle Energy Techniques in the Treatment of Chronic Non-specific Low Back Pain
Condition: Low Back Pain, Mechanical
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      Chronic Non-Specific Low Back Pain is characterized as a tension, soreness and stiffness.
      Various studies, defined MET as a manual medicine treatment procedure that involves the
      voluntary contraction of the subject's muscle in a precisely controlled direction, at varying
      levels of intensity, against a distinctly executed counterforce applied by the therapist.
    

Detailed description: 
      Chronic Non-specific LBP is located in region below lower costal margins and above inferior
      gluteal margins with or without any referred pain in legs, an essentially non-attributable to
      any specific cause. It may lasting for more than 7-12 months and affect individual over a
      long period of time once in a lifetime at least. METs is useful in increasing extensibility
      and range of motion of various joints and provides good results in the patients with back
      pain. These techniques are used as the treatment of weakened muscles, restricted joints,
      reducing pain reliving muscle tension & spasm, & increased strength of the muscle. MET is a
      verstile, safe, gentle technique traditionally used to address muscular strain, PAIN, local
      edema and joint dysfunction. It was reported that post isometric relaxation is considered a
      highly effective therapy for back dysfunction patients.
    

Intervention name(s): Muscle Energy Technique plus Conventional Physical Therapy; Conventional Physical Therapy
Intervention type(s): Other; Other
Intervention description(s): Post-Isometric Relaxation of the Muscle Energy Techniques will be applied to Spinal Stabilizers and Mechanoreceptors. Hold time will be 7 seconds with 5 seconds rest between two performance x 3 times /session. Whereas, Conventional Physical Therapy consists of hot pack, TENS, Ultrasonic along with stretching and exercises of back musculature.; Conventional Physical Therapy consists of hot pack, TENS, Ultrasonic along with stretching and exercises of back musculature.
Other intervention name(s): Post-Isometric Relaxation Technique plus Conventional Physical Therapy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Muscle Energy Technique; Physical Therapy; Pain; Functional Disability; Fear Avoidance Beliefs; Quality of Life; Range of Motion
Assessment of Needs of Moisturizers After Various Laser Treatments
Condition: Dermatologic Disorders; Injury Due to Laser
MeSH terms: Skin Diseases
Study type: Interventional
Phase: Phase 4

Summary: 
      Assessment of needs of moisturizers after various laser treatments
    

Detailed description: 
      The investigators would like to assess of needs of moisturizers after various laser treatment

      : by investigating the changes in the skin barrier function after fractional carbon dioxide
      laser and fractional Er:Glass laser in mice and human skin
    

Intervention name(s): Physiogel; Moisturizer
Intervention type(s): Other; Other
Intervention description(s): Application of moisturizer on laser-treated area; Application of moisturizer on laser-treated area
Other intervention name(s): Other moisturizer: Palmitoylethanolamide; Other Names:Physiogel; Other moisturizer: Palmitoylethanolamide; Other Names:Physiogel
Intervention MeSH terms: Palmidrol
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Moisturizer, laser
Study to Assess Effect of Cyclosporine on the Blood Levels of Ticagrelor
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to assess the effect of Cyclosporine on the blood levels of
      Ticagrelor.
    

Detailed description: 
      A Single-Center,Open-Label,Randomized,3-Treatment,3-Period Cross-Over Study to Investigate
      the Potential Effect of Cyclosporine on the Pharmacokinetics, Safety, and Tolerability of
      Ticagrelor and the Effect of Ticagrelor on the Pharmacokinetics, Safety, and Tolerability of
      Cyclosporine.
    

Intervention name(s): cyclosporine; ticagrelor
Intervention type(s): Drug; Drug
Intervention description(s): Oral tablets, 600 mg , single dose; Oral tablets, 180 mg, single dose
Intervention MeSH terms: Cyclosporine; Ticagrelor; Cyclosporins
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Phase 1; Healthy male volunteers; pharmacokinetics; cyclosporine; ticagrelor; Bioavailability (plasma AUC, Cmax, plasma AUC0-t, t1/2λz, tmax)
Normobaric Hyperoxia Combined With Endovascular Treatment in Acute Ischemic Stroke (OPENS-2)
Condition: Stroke, Acute; Neuroprotection
MeSH terms: Stroke; Ischemic Stroke; Hyperoxia
Study type: Interventional
Phase: Phase 2

Summary: 
      The current endovascular treatment has increased the recanalization rate to more than 90%.
      Even so, the prognosis rate of stroke is still less than 50%. Our previous research confirmed
      that the neuroprotective effect of Normobaric Hyperoxia (NBO) from multiple perspectives.
      However, the clinical study on NBO was not satisfactory, which might be due to the absence of
      vascular recanalization therapy. Therefore, The investigators conducted this RCT study to
      further explore the Efficacy and safety of NBO combined with endovascular treatment in
      patients with acute ischemic stroke.
    


Intervention name(s): Normobaric Hyperoxia; Sham Normobaric Hyperoxia; Endovascular Thrombectomy
Intervention type(s): Drug; Drug; Procedure
Intervention description(s): Within 6 hours after stroke onset, patients were randomized into the NBO group and immediately given 100% oxygen inhalation (no more than 30 minutes after randomization) at a ventilation rate of 10L/ min using a sealed non-ventilating oxygen storage mask and keep giving oxygen for 4 hours. If the patient needs to be intubated with a ventilator to maintain ventilation, the FiO2 should be set to 1.0.; For Sham NBO group, Patients were immediately given oxygen inhalation (no more than 30 minutes after randomization) at a ventilation rate of 1l/min using the same mask and keep giving oxygen for 4 hours. If the patient needs to be intubated with a ventilator to maintain, the FiO2 should be set to 0.3 and gradualy incerased if spO2≤94%；; EVT is the international guidelines for the treatment of acute ischemic stroke with lage vessel occlusion.
Other intervention name(s): NBO; Sham NBO; EVT
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Normobaric hyperoxia; Endovascular treatment; Acute ischemic stroke
Rheoparin-coated Tubing System for Minimized Extracorporeal Circulation (MECC)
Condition: Extracorporeal Circulation; Inflammation; Blood Coagulation; Intracranial Embolism
MeSH terms: Intracranial Embolism; Embolism; Inflammation
Study type: Interventional

Summary: 
      In this study, the investigators would like to compare a heparin-coated tubing system for
      minimized extracorporeal circulation (MECC) with the conventional tubing system for MECC,
      which does not contain heparin coating. The MECC system has been used since 14 years in the
      investigators' hospital as an extracorporeal system to support circulation and provide oxygen
      to the tissues during coronary artery bypass grafting. Until today, the investigators
      performed more than 5000 MECC procedures in their department.
    

Detailed description: 
      Background

      The investigators would like to investigate a new composition of their MECC system in
      patients receiving coronary artery bypass surgery. Normally, the MECC system induces
      complement system activation and coagulation cascade, which could have a negative impact on
      postoperative outcome. A tubing system containing heparin (rheoparin) could contribute to a
      better biocompatibility in terms of a diminished activation of inflammatory reactions and a
      reduction of cerebral embolic load, which is a regular issue during extracorporeal
      circulation due to formation of solid and gaseous microemboli in the tubing system.

      Objective

      The aim is to investigate biocompatibility (coagulation, inflammation) and influence on
      cerebral embolic load of the rheoparin-coated MECC system and to compare the results with the
      current MECC system containing a rheoparin-free tubing system.

      Methods

      Patients undergoing elective coronary artery surgery are randomized to receive extracorporeal
      circulation using the MECC system with or without rheoparin coating. All procedures are
      performed according to the institutional standards.
    

Intervention name(s): MECC system with rheoparin coating
Intervention type(s): Device
Intervention description(s): MECC system for extracorporeal circulation equipped with rheoparin coating.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Preventive Effects of Ginseng Against Atherosclerosis
Condition: Ischemic Stroke; Atherosclerosis
MeSH terms: Stroke; Ischemic Stroke; Atherosclerosis
Study type: Interventional

Summary: 
      This study is a 12-month, double-blind, randomized, placebo-controlled trial. The purpose of
      this study is to determine whether ginseng is effective in the prevention of atherosclerosis
      and subsequent ischemic stroke. High-risk patients with severe atherosclerosis in the major
      intracranial arteries and extracranial carotid artery were enrolled.
    


Intervention name(s): Ginseng; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Korean Red Ginseng extract tablet (0.5 grams/tablet, 2 tablets twice a day) daily for 12 months.; Placebo (0.5 grams/tablet, 2 tablets twice a day) daily for 12 months.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Ginseng; Stroke; Quantitative magnetic resonance flow analysis
Alcohol, Gut Leakiness, & Liver Disease
Condition: Alcoholic Liver Disease
MeSH terms: Liver Diseases; Liver Diseases, Alcoholic
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The goal of this study is to investigate the role of gut leakiness in alcoholic liver
      disease. Gut leakiness may be the missing susceptibility factor that explains why some
      alcoholics develop liver disease and others don't. For this study, subjects 480 (240 male,
      240 female, ages 18-80) will be recruited. Alcoholic subjects will be recruited from
      outpatient & inpatient alcohol detoxification units from Rush, Loyola & two halfway houses
      (one for women, one for men); patients with liver disease from GI/Hepatology Services at
      Rush, Hines VA Hosp & Loyola University; and controls from hospital staffs. All subjects will
      fill out a detailed questionnaire, be interviewed by the study coordinator & undergo an exam
      by the PI to ensure that all inclusion criteria are satisfied. All subjects will have a urine
      collection for tests of intestinal permeability (urinary sugars). Gut leakiness will be
      determined by the amount of sugars in the urine.
    


Intervention name(s): Sugar test; Aspirin Challenge
Intervention type(s): Other; Drug
Intervention description(s): All participants will take two sugar tests ( sugar cocktail consisting of mannitol & lactulose) subjects within 2-3 days of the initial sugar test.; All participants will take a sugar test after 2 doses of aspirin, 1.3 g each given at 12 & 1 hour before the sugar drink.
Intervention MeSH terms: Aspirin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: intestinal permeability
Fat Cell Size and Overfeeding and Etopic Study
Condition: Over Eating
MeSH terms: Hyperphagia
Study type: Interventional

Summary: 
      It has been shown that large fat cells are associated with more risks for insulin resistance
      and more cardiovascular risk factors such as high cholesterol or triglycerides.
    

Detailed description: 
      This study will look at fat cell size and how it affects fat deposition, insulin resistance
      and muscle oxidative capacity. A comparison will be made with the differences between
      participants with larger versus smaller fat cells in insulin resistance and blood levels of
      lipids. The study will also determine if characteristics of fat cells and muscle can predict
      the development of weight gain-induced insulin resistance.
    

Intervention name(s): Overfeeding
Intervention type(s): Other
Intervention description(s): We overfed 40 young, healthy adults by 40% of their baseline energy requirements for 8 weeks. The diet consisted of 41% carbohydrate, 44% fat, and 15% protein.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Exploratory Study of Propofol and Fentanyl Pharmacodynamics
Condition: General Anesthesia
Study type: Interventional
Phase: Phase 1

Summary: 
      Exploration of the hypothesis that general anesthesia is not a singular threshold but is a
      continuum of central nervous system depression dependent on interpretation of nociceptive
      stimuli.
    


Intervention name(s): propofol
Intervention type(s): Drug
Intervention description(s): peripheral IV of propofol at increasing dose levels
Intervention MeSH terms: Propofol
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science