bioihbjkbjnl/mcl2 huggingface dataset:
Plasma Lipid Response to Glucose Drink
Condition: Hyperlipidemias
MeSH terms: Hyperlipidemias
Study type: Interventional

Summary: 
      During dietary fat absorption, the gut packages the majority of the fats into lipid particles
      that are secreted into blood circulation. The gut is also capable of storing a considerable
      amount of fats that can be released at a later time upon receiving certain stimulus signals.
      One of the signals is glucose ingestion. This protocol examines blood lipid responses to a
      glucose drink. Participants drink a fatty formula and 5 hours later drink either a glucose
      solution or water (as control), in one of two randomized study visits. Blood lipid levels are
      monitored throughout the study period.
    

Detailed description: 
      Participants are recruited after obtaining informed consent. They first have a high fat
      liquid formula. 5 hours later, they drink 50 grams of glucose in 50 ml of water in one visit
      and 50 ml of water in another. The 2 visits are randomized. Blood samples are taken before
      and after they drink the high fat liquid formula, and continued until 3 hours after they
      drink glucose or water. Lipid levels in the blood samples are measured in the lab.
    

Intervention name(s): Glucose; Water
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Glucose drink; Control
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Tadalafil and Lenalidomide Maintenance With or Without Activated Marrow Infiltrating Lymphocytes (MILs) in High Risk Myeloma
Condition: Multiple Myeloma
MeSH terms: Multiple Myeloma; Neoplasms, Plasma Cell
Study type: Interventional
Phase: Phase 2

Summary: 
      This research is being done to find out if altering the immune system by giving activated
      marrow infiltrating lymphocytes (MILs) can improve outcomes for multiple myeloma patients who
      receive a standard autologous stem cell transplant.
    


Intervention name(s): aMIL; No aMIL
Intervention type(s): Biological; Drug
Intervention description(s): On day 0, patients will receive auto transplant followed by Tadalafil and aMIL. At day 60, patients will receive Lenalidomide.; On day 0, patients will receive auto transplant followed by Tadalafil. At day 60, patients will receive Lenalidomide.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Research Study To Compare Two Kinds Of Daily Headache
Condition: Migraine
MeSH terms: Migraine Disorders; Headache
Study type: Observational

Summary: 
      Chronic daily headache has been classified into several categories. One category is of sudden
      onset and is called New Daily Persistent Headache (NDPH). Another category of daily headache
      evolves gradually and is called Transformed Migraine (TM). This research study is being
      conducted to compare people with these two kinds of daily headache in order to improve our
      understanding of these conditions.
Use of the Atkins Diet for Children With Intractable Epilepsy: A Comparison of Daily Carbohydrate Limits
Condition: Epilepsy
MeSH terms: Epilepsy
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is designed to further investigate the use of a modified Atkins diet for children
      with intractable, daily seizures. It is a follow-up to a study recently completed by our
      institution. In this 6-month study, children will be randomized to either 10 or 20 grams of
      carbohydrate per day, then crossed over to the opposite amount at 3 months.
    


Intervention name(s): Modified Atkins diet
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Epilepsy; Ketosis; Atkins; seizures
Using Baby Books to Promote Maternal and Child Health
Condition: Condition 1 - Educational Condition (Educational Book Group); Condition 2 - Non-educational Condition (Non-educational Book Group); Condition 3 - Control Condition (No-book Group)
MeSH terms: Disease
Study type: Interventional

Summary: 
      The Baby Books Project tests whether embedding educational information into baby books can
      improve the health and wellbeing of first-time mothers and their young children.
    

Detailed description: 
      This study tests the efficacy of embedding educational information (i.e., pediatric
      anticipatory guidance) into baby books that first-time mothers read to their infants. This
      3-group longitudinal study recruited first-time mothers in their third trimester of
      pregnancy, randomly assigned them to conditions, and followed them until the child was 18
      months of age. One group received educational baby books, another group was given the same
      illustrated books with non-educational text, and the third group was not given any books.
      Thus, the effects of educational reading could be parsed from the effects of reading alone.
      The study aimed to test whether embedding pediatric anticipatory guidance in picture books is
      an effective method for increasing maternal knowledge of child development, parenting
      strategies, and safety practices, improving parenting beliefs and attitudes (e.g., parenting
      efficacy, importance of reading, use of corporal punishment), supporting optimal parenting
      practices (e.g., breastfeeding and nutrition, responsiveness, safety practices), improving
      maternal health (stress, depression), and supporting children's healthier development
      (injuries, illness, immunizations, and linguistic, social, and cognitive development).

      Survey and observational data collection occurred in participants' homes during their third
      trimester of pregnancy and when their child was 2, 4, 6, 9, 12, and 18 months of age. Twelve
      phone call interviews were conducted between these home visits. When children were 18 months,
      a retrospective medical chart audit was conducted.
    

Intervention name(s): Educational Content/Pediatric Anticipatory Guidance; Book provision
Intervention type(s): Behavioral; Behavioral
Intervention description(s): educational information from Bright Futures Guidelines for Health Supervision for birth to 18 months; Given free books prenatally and at 2, 4, 6, 9, 12, and 18 months postpartum
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Prevention
Keywords: anticipatory guidance; baby books; safety
Study Evaluating RGH-188 in the Treatment of Patients With Schizophrenia
Condition: Schizophrenia
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a study designed to evalute the safety and efficacy of RGH-188 in the treatment of
      acute schizophrenia. This study will be 10 weeks in duration; 6 weeks double-blind treatment,
      and 4 weeks safety follow-up. All patients meeting the eligibility criteria will be
      randomized to one of the three treatment groups--one of two doses of RGH-188 or placebo
    


Intervention name(s): RGH-188
Intervention type(s): Drug
Intervention MeSH terms: Cariprazine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Schizophrenia
Body Temperature and Perioperative Bleeding in Adolescent Idiopathic Scoliosis Surgery
Condition: Hypothermia; Anesthesia
MeSH terms: Scoliosis; Hypothermia
Study type: Interventional

Summary: 
      In this study, patient groups in which normothermia is preserved by using multiple active
      warming methods in the intraoperative period in AIS surgery, followed by a single compressed
      air blowing system and allowed mild to moderate hypothermia were compared.
    


Intervention name(s): heating
Intervention type(s): Procedure
Intervention description(s): patients were aggressively warmed using multiple heating methods such as pressurized air heater and intravenous fluid heater
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Predictability of Distalization and Derotation of the Carriere Motion Appliance.
Condition: Dental Malocclusion
MeSH terms: Malocclusion
Study type: Interventional

Summary: 
      To analyze the distalization or distal tooth displacement and derotation angle produced by
      Carriere Motion Appliance® (CMA) by using a repeatable and reproducible measurement digital
      technique.
    

Detailed description: 
      15 patients with Class II molar and canine relationship were submitted to orthodontic
      treatment with CMA. All patients were exposed preoperatively (STL1) and postoperatively
      (STL2) to a digital impression and afterwards were uploaded into a specific cephalometric
      software to allow the automatic mesh networks alignment of the STL digital files.
      Subsequently, the distal tooth displacement of upper canines and first upper molars and also
      the derotation angle of first upper molars were measured. The repeatability and
      reproducibility were analyzed by Gage R&R statistical analysis.
    

Intervention name(s): Carriere Motion Appliance®
Intervention type(s): Device
Intervention description(s): To analyze the distalization or distal tooth displacement and derotation angle produced by Carriere Motion Appliance® in a period of 4 months.
Intervention model: Single Group Assignment
Intervention model description: This study included 15 patients with Class II molar relationship and Class II canine relationship treated using Carriere Motion Appliance®.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Class II malocclusion; Carriere Motion Appliance; Distalization; Derotation
Sun Protection Factor Assay (SPF Assay 204/2016)
Condition: Sunscreening Agents
Study type: Interventional

Summary: 
      To evaluate the Sun Protection Factor efficacy on human skin.
    


Intervention name(s): BAY987521
Intervention type(s): Drug
Intervention description(s): Each 50 cm*2 test site area of a subject requires 100 mg of a test material to obtain a standard 2 mg/cm*2 test application. (Formulation Code:Z09-054)
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Effect of Amino Acid Addition to a Drink on the Appearance of Ingested Water in Body Fluids
Condition: Rate of Water Appearance/Delivery in the Blood Water Balance
Study type: Interventional

Summary: 
      To determine the effects of a moderate amount of amino acids on the rate of water absorption
      and availability as a precursor fluid for sweat. Young and healthy (male or female)
      volunteers will take part in three experimental trials. In each trial, volunteers will be
      given one of two commercially available sports drinks or a commercially available sport drink
      with added amino acids in a double-blinded, randomised, crossover design. Each drink will be
      a single 600 mL bolus. All beverages will be labelled with deuterium (D2O). Trials will be
      compared for temporal accumulation of deuterium in plasma over the course of 60 minutes.
      Whole blood measurements of haemoglobin and haematocrit will also be made and plasma volume
      changes calculated. It is hypothesised that the amino acid trial will increase the rate of
      fluid absorption.
    


Intervention name(s): Composition of Sports Drink
Intervention type(s): Other
Intervention description(s): The composition of sport drinks will be manipulated to determine the effect of drink composition on the appearance of ingested water in body fluid.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Double-blind, randomised, crossover design
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Health2010-14: Monitoring Biomarkers of Chronic Diseases in the General Population
Condition: Cardiovascular Disease; Type 2 Diabetes; Asthma; Allergy; Osteoporosis
MeSH terms: Osteoporosis; Cardiovascular Diseases; Chronic Disease
Study type: Observational

Summary: 
      The overall aim of the Health2010-14 is to monitor the prevalence and trends of common
      chronic diseases (osteoporosis, diabetes, cardiovascular disease, asthma, allergy, and
      eczema) that are often un-diagnosed in the general population as well as biomarkers of
      micronutrient status. Specific aims include identification of novel lifestyle and genetic
      risk factors for the above diseases by investigating gene-lifestyle interactions.
    

Detailed description: 
      Over a 5-year period a series of population-based studies are carried out including a total
      of up to 10,000 persons aged 18-69 years selected from the general population of Copenhagen,
      Denmark. The study also include a follow-up of a previous population study (the Health2006).
      Participants complete questionnaires on health, lifestyle, and social factors and undergo a
      health examination including measurements of metabolic biomarkers, allergy tests,
      anthropometric measures, bioimpedance, biomarkers of micronutrients, spirometry.
    

Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Random samples of persons living in 10 municipalities in the Western part of the Capital
        Region of Denmark (Copenhagen).
      
Biospecimen description: 
      Urine, serum, whole blood, extracted DNA
    
Keywords: epidemiology; risk factors; micronutrients
Knowledge and Practice of Chinese Medical Specialists Regarding Chronic Hepatitis B Virus Infection
Condition: Hepatitis B
MeSH terms: Hepatitis A; Hepatitis B; Hepatitis B, Chronic; Hepatitis
Study type: Observational

Summary: 
      The aim of this study was to evaluate knowledge and behavior of physicians regarding
      Hepatitis B Virus. The investigators designed a 30-item self-administered questionnaire
      assessing physicians' knowledge and behavior regarding chronic Hepatitis B Virus infection.
      These results provide data support for updating guidelines, continuing training, and even
      developing policies in medical insurance.
    

Detailed description: 
      Schedule of the study:

      Before March 1, 2015: study design, completing questionnaire design, and all preparatory
      work; Before July 1, 2015: a kick-off meeting for plot study, modifying the questionnaire,
      and obtaining all the questionnaires; Before September 30, 2015: finishing data entry,
      statistical analysis, drafting the report, and issued a final report
    

Intervention name(s): physicians
Intervention type(s): Other
Intervention description(s): physicians taking care of patients with chronic Hepatitis B Virus infection, without intervention
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        physicians fullfill the following criterion:

          1. Mainly engaged in liver disease diagnosis and treatment;

          2. Diagnosis and treatment at least 10 patients with chronic Hepatitis B Virus infection
             per week.
Post-exercise Recovery of DOMS in Recreational Athletes
Condition: Injury;Sports
MeSH terms: Athletic Injuries
Study type: Interventional

Summary: 
      The main goal of this study was to investigate the effectiveness of cryo-sauna in preventing
      the development of DOMS in the lower extremity. The second goal is to analyze the rate of
      regenerative changes in the right muscles after acute fatigue-induced exercises.
    

Detailed description: 
      The main goal of this study was to investigate the effectiveness of cryo-sauna in preventing
      the development of DOMS in the lower extremity. The second goal is to analyze the rate of
      regenerative changes in the right muscles after acute fatigue-induced exercises.

      This study design was a randomized, controlled single-blind trial with repeated measures.
      Moreover, the design was prepared according to the Consolidated Standards of Reporting Trials
      (CONSORT) for pragmatic trials. Participants were assigned into two groups: (1) experimental
      group (CRYO, n =16) - cryostimulation using a cryo sauna; and (2) control group (CONT, n =
      15) - without any intervention. This study was conducted in the Physical Exercise Laboratory.
      Both groups, CRYO and CON performed a fatigue-induced protocol consisting of counter-movement
      jumps (CMJ) (10 set for 10 repetitions). After the fatigue exercises, only CRYO underwent
      cryo sauna intervention including entry immediately after, 24, 48, and 72 hours
      post-exercise. The order of measurements at baseline included: blood sample testing (creatine
      kinase, myoglobin, leukocytes) and muscle stiffness of the lower extremity. All measurements
      we collected at baseline, immediately post, 24, 48, 72, and 96 hours post-exercise.
    

Intervention name(s): Cryosauna
Intervention type(s): Other
Intervention description(s): The intervention was Cryosauna - cryostimulation at -110°C for 1.5 minutes, for four consecutive days.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized controlled trial
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Screening
Keywords: DOMS; injury prevention; performance; muscle properties
Impact of Diet on Functional Gastrointestinal Symptoms
Condition: Gastrointestinal Disorder, Functional
MeSH terms: Gastrointestinal Diseases; Digestive System Diseases
Study type: Observational

Summary: 
      This cross-sectional survey study is to determine the prevalence of functional
      gastrointestinal (GI) disorders in the general population and to describe common triggers for
      food-related GI symptoms.
    

Detailed description: 
      Functional gastrointestinal disorders, involving symptoms such as gas/bloating, diarrhea,
      constipation and abdominal pain, are estimated to impact between 35 and 45 million Americans,
      an overwhelming 15-20% of the population. These symptoms are responsible for upwards of 20
      billion dollars in healthcare costs and extensive loss of quality of life for sufferers.
      Moreover, many patients suffer in silence, with 67% of subjects waiting more than a year
      before treatment, and 11% waiting over 10 years. Irritable bowel syndrome is the most
      prevalent functional gastrointestinal disorder, and several recent studies support the idea
      that dietary modifications may be key to alleviating this condition.

      The purpose of this study is to document gastrointestinal symptoms among the US population,
      as well as to ascertain awareness and utilization of dietary treatments that exist.
    

Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        General popultion in the United States
The Effect of Virtual Reality Glasses Applied During Emergency Surgical Intervention
Condition: Anxiety
MeSH terms: Emergencies; Anxiety Disorders
Study type: Interventional

Summary: 
      This randomized controlled trial evaluates the effect of virtual reality glasses applied
      during emergency surgical intervention with local anesthesia on patients anxiety. This study
      hypothesizes that virtual reality glasses reduces anxiety.
    

Detailed description: 
      The sample of this study consisted of 138 patients in the experimental (n=69) and control
      groups (n=69). Virtual Reality (VR) application will be applied to the experimental group
      during the emergency surgical intervention under local anesthesia. Anxiety level will be
      assessed with the Spielberger State Anxiety Scale and measured by physiological responses of
      anxiety such as systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate
      (HR), respiratory rate (RR) and peripheral oxygen saturation (SpO2) before and after VR
      application. In the control group, no application will be made except for standard care only.
    

Intervention name(s): Virtual Reality Glasses
Intervention type(s): Device
Intervention description(s): In addition to the routine practice of the emergency service, the virtual reality (VR) group will watch a video with VR glasses during the emergency surgical intervention under local anesthesia. Before the emergency surgery, the patients will be asked to wear a VR glasses compatible with mobile phones with android operating system and a headset that minimizes sound loss. Patients will be shown their preferred 3D licensed video software with relaxing music in the background. VR glasses will be put on the patients before starting the emergency surgical procedure under local anesthesia and applied until the procedure was completed. Patients will be asked to refill the The State Anxiety Inventory at the end of the emergency surgical intervention. At the same time, blood pressure, heart rate, respiratory rate, SpO2 values will be monitored on a portable monitor.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: prospective, parallel, two arm, randomized controlled clinical trial
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Anxiety; Virtual reality glasses; Emergency Surgery
MF-4181 for the Reduction of Scars Secondary to Abdominoplasty or Laparoscopy/Laparotomy Gynecologic Procedures
Condition: Scars
Study type: Interventional
Phase: Phase 2

Summary: 
      The objective of the study is to evaluate the safety and preliminary efficacy of MF-4181, a
      hydrogel scaffold, in improving scars and their resulting consequences following
      abdominoplasty or laparoscopy/laparotomy gynecologic procedures.
    


Intervention name(s): MF-4181; Standard surgical wound closure
Intervention type(s): Other; Other
Intervention description(s): Surgical procedure will be performed as per the standard of care. Scar halves randomized to treatment with device (MF-4181), opposite side treated per standard of care.; Surgical procedure will be performed as per the standard of care. Scar halves randomized to treatment with device (MF-4181), opposite side treated per standard of care.
Other intervention name(s): Hydrogel scaffold
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment