Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®).
Condition: Chronic Periodontitis; Bone Loss; Intrabony Periodontal Defect
MeSH terms: Periodontitis; Chronic Periodontitis
Study type: Interventional
Phase: Phase 4

Summary: 
      The aim of this study is to evaluate and compare the regenerative potential of Advanced
      Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) bone graft in the treatment of
      intrabony defects in chronic periodontitis patients.
    

Detailed description: 
      45 sites with vertical intrabony alveolar defects will be selected. These defect sites will
      be allocated randomly into 3 groups as Group I, Group II and Group III.

        -  Group I will be treated with open flap debridement and filled with A-PRF

        -  Group II will be treated with open flap debridement and filled with Bioactive glass
           (Perioglas®)

        -  Group III will be treated with open flap debridement and filled Bioactive glass
           (Perioglas®) and A-PRF.
    

Intervention name(s): open flap debridement and filled with A-PRF ( Advanced platelet rich fibrin); open flap debridement and filled with Bioactive glass (Perioglas®); open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF
Intervention type(s): Procedure; Procedure; Drug
Intervention description(s): After phase 1 therapy, surgical procedure would be carried out in the selected patients under aseptic conditions. Full thickness mucoperiosteal Kirkland flap would be raised on both buccal and lingual sides using periosteal elevator. Pocket lining epithelium would be removed and a thorough debridement and root planing would be done in the intrabony defect by using Gracey curettes and universal curettes. After placement of A-PRF in bony defect site the mucoperiosteal flaps would be sutured for complete soft tissue closure.; After phase 1 therapy, surgical procedure would be carried out in the selected patients under aseptic conditions. Full thickness mucoperiosteal Kirkland flap would be raised on both buccal and lingual sides using periosteal elevator. Pocket lining epithelium would be removed and a thorough debridement and root planing would be done in the intrabony defect by using Gracey curettes and universal curettes. After placement of perioglas in bony defect site the mucoperiosteal flaps would be sutured for complete soft tissue closure.; After phase 1 therapy, surgical procedure would be carried out in the selected patients under aseptic conditions. Full thickness mucoperiosteal Kirkland flap would be raised on both buccal and lingual sides using periosteal elevator. Pocket lining epithelium would be removed and a thorough debridement and root planing would be done in the intrabony defect by using Gracey curettes and universal curettes. After placement of perioglas with A-PRF in bony defect site the mucoperiosteal flaps would be sutured for complete soft tissue closure.
Other intervention name(s): perioglas; perioglas
Intervention MeSH terms: Methamphetamine
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 45 sites with vertical intrabony alveolar defects will be selected. These defect sites will be allocated randomly into 3 groups as Group I, Group II and Group III.
Group I will be treated with open flap debridement and filled with A-PRF
Group II will be treated with open flap debridement and filled with Bioactive glass (Perioglas®)
Group III will be treated with open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: intrabony periodontal defect; regeneration; platelet rich fibrin; bioactive glass