bioihbjkbjnl/mcl2 huggingface dataset:
Transitional Treatment of Adolescents in Family Therapy
Condition: Substance Abuse
MeSH terms: Substance-Related Disorders
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to test different treatments to reduce relapse for drug-abusing
      adolescents who have completed family therapy. Adolescents receive 12 weeks of family
      therapy, designed to strengthen family relationships and develop skills for helping the
      adolescent avoid drug use. Then they are randomly assigned to receive one of three eight-week
      follow-up treatments: phone calls from a project therapist, group therapy, or a customized
      schedule of therapist visits with the adolescent, the adolescent's family and teachers,
      coaches, probation officers and others who can help the adolescent reach or maintain
      abstinence. Families are assessed using questionnaires and interviews before, during and
      after treatment, to provide information about family functioning, the adolescent's drug use,
      the adolescent's peers and other factors that may contribute to treatment success or failure.
      Adolescents also provide urine specimens for drug screening at assessment visits. Study
      investigators expect the study will show that a functional family environment and insulating
      adolescents from the influence of peers who use drugs will help prevent relapse for
      adolescents who have received family therapy.
    


Intervention name(s): MTI, Minimal Transitional Intervention; GTI, Group Transitional Intervention; STI, Systems Transitions Intervention
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Following 12 weeks of Functional Family Therapy (FFT), semi-weekly phone calls from a therapist for eight weeks.; Following 12 weeks of FFT, weekly one-hour sessions of group therapy for eight weeks.; Following 12 weeks of FFT, an individualized eight-week series of therapist meetings with the adolescent, family, police, teachers, coaches and others who can support the adolescent's reduced drug use.
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: adolescent substance abuse
Dexamethasone Tolerability in the Treatment of Acute Asthma in Children
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional

Summary: 
      The purpose of this study is to assess whether smaller volumes of oral dexamethasone result
      in better tolerability, specifically less vomiting, in pediatric patients during an acute
      asthma exacerbation.
    


Intervention name(s): Ora Sweet; Dexamethasone
Intervention type(s): Drug; Drug
Intervention description(s): A pharmaceutical suspending vehicle and flavouring agent added to the dexamethasone. All arms received the same amount of dexamethasone based on the child's weight, only in different volumes.
Intervention MeSH terms: Dexamethasone
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: pediatric; dexamethasone; management; corticosteroids; asthma
Assessment of the Pulmonary Diffusion Capacity in Healthy Infants and Infants With Chronic Lung Disease
Condition: Infant, Premature; Bronchopulmonary Dysplasia; Asthma
MeSH terms: Lung Diseases; Bronchopulmonary Dysplasia
Study type: Observational

Summary: 
      The purpose of this study is to evaluate how easily gas can be taken up by the lung. We are
      comparing infants born premature <32 weeks gestation to infants born full term >37 weeks. We
      hope to evaluate the differences between the two groups in order to learn more about
      premature lung growth and development.
    

Detailed description: 
      We hypothesize that infants who were born prematurely but are clinically without chronic
      respiratory disease have a lower lung diffusion capacity than healthy infants born at full
      term, when evaluated at comparable post-conception ages. In addition, prematurely born
      infants that develop chronic lung disease have an even lower diffusion capacity than healthy
      premature infants and full term infants. A lower diffusion capacity, when normalized to lung
      volume, would be consistent with decreased alveolarization and alveolar surface area in the
      infants born prematurely. We will study the age range of 1 to 24 month as this represents the
      period of rapid lung growth.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Recruitment for premature infants were through Infant Lung Disease clinic at Riley Hospital
        for Children and IU NICU. Healthy full term infants were recruited through advertisements
        in local newspapers.
      
Keywords: Infant, Premature; Bronchopulmonary Dysplasia; Asthma
Home-Based Asthma Support and Education for Adults
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional

Summary: 
      This study tests the hypothesis that community health workers providing home visits to
      provide education and support for self-management of asthma, assessment of the home for
      environmental triggers, resources for asthma control, and assistance in effective
      communication with medical providers over the course of one year would reduce asthma
      morbidity, asthma-related urgent health care use and exposure to indoor asthma triggers among
      low income adults with not well controlled asthma.
    

Detailed description: 
      We used a randomized controlled parallel group design to compare the intervention to a
      usual-care control group. We attempted to evaluate the effectiveness of the intervention in
      the "real world," rather than its ideal efficacy.

      The CHWs used protocols that specified education content, participant skill development and
      participant and CHW actions. The CHWs modified their approach to meet the priorities of
      participants using motivational interviewing techniques. They addressed asthma
      patho-physiology, reliever and controller medication use, self-monitoring, use of an asthma
      action plan, environmental assessment, trigger avoidance, effective use of the health care
      system, successful communication with health care providers, and weight control (obesity is
      associated with increased asthma symptoms). Participants also received low-literacy
      educational materials, in English or Spanish. The education concepts and environmental
      assessment activities were based on our prior healthy homes work modified for adults.
    

Intervention name(s): Community Health Worker support
Intervention type(s): Behavioral
Intervention description(s): For the intervention group, a trained Community Health Worker (CHW) provided education, support and service coordination through home visits. The CHW first made an in home assessment visit. At the assessment visit, the participant had the opportunity to ask questions and sign written consent. During this visit, the CHW assessed the participant's knowledge of asthma, current status of asthma control, challenges with controlling asthma, self-management practices and exposure to asthma triggers. After enrollment, the participant received up to four follow-up educational visits 0.5, 1.5, 3.5 and 7 months later. In addition to scheduled visits, the CHWs worked with their participants on an as-needed basis via telephone, email, or additional home visits.
Other intervention name(s): CHW intervention
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: asthma
EXCEL: Change in Cardiometabolic Disease Risk Factors During an Interactive Fitness Program
Condition: Cardiovascular Disease
MeSH terms: Cardiovascular Diseases
Study type: Interventional
Phase: Phase 1

Summary: 
      Childhood obesity has increased in prevalence over the past several decades and is predictive
      of adult type 2 diabetes and cardiovascular disease (CVD). Recent studies of children and
      youth suggest that exercise reduces cardiometabolic risk factors. Minimal data are available,
      however, on the effects of "exergaming" , interactive technology- mediated approaches to
      increasing physical activity in children and youth. This project involves a partnership
      between UMass Boston/GoKids Boston and Children's Hospital Boston featuring an
      interdisciplinary team of researchers and clinicians from pediatric cardiology, nursing,
      prevention and behavioral sciences and exercise physiology and is designed to examine the
      effects of exergaming on moderate or vigorous physical activity (MVPA) indices of adiposity,
      risk factors for cardiometabolic disease and self-competence in Boston Public School
      children. It is hypothesized that participation in the EXCEL/exergaming intervention for 60
      minutes, three times per week for 12 weeks will significantly increase MVPA (as measured by
      accelerometers), pre- to- post intervention and compared to an Advice only (Nutrition
      Education) group.Results of this pilot study will guide and inform a larger study of
      exergaming in children from the Boston Public Schools.
    


Intervention name(s): EXCEL; EXCEL; Nutrition Education ONLY
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Children in the EXCEL intervention will receive 12 weeks of supervised physical activity, guided by principles of behavior change, in the form of exergaming (technology-mediated interactive physical activity)3 times per week for 12 weeks and will also receive weekly group nutrition education sessions; Participants in the EXCEL intervention will receive 12 weeks of supervised physical activity in the form of exergaming (technology-mediated physical activity). Sessions will be held 3 times per week with 60 minutes of supervised physical activity.; Children in the nutrition education group will receive 30 minutes per week of group nutrition education in the school environment and delivered by a registered dietitian The nutrition education sessions will be identical to those provided for the EXCEL group.
Other intervention name(s): EXERGAMING
Intervention MeSH terms: Chlorhexidine; Chlorhexidine gluconate
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Prevention
Keywords: physical activity; cardiometabolic risk; children
Social Skills in Children With Autism Spectrum Disorders
Condition: Pervasive Developmental Disorders
MeSH terms: Autism Spectrum Disorder; Developmental Disabilities; Child Development Disorders, Pervasive
Study type: Interventional

Summary: 
      To evaluate whether a structured social skills program, called Social Skills Development,is
      superior to a wait list control group on measures of interpersonal interaction. The Social
      Skills Development (SSD) is a 16-week, group intervention that uses activities and peer
      tutors to promote interpersonal skills in children 8 to 11 years of age with Autism Spectrum
      Disorders.Following a diagnostic and social skills assessment,children are randomly assigned
      to SSD or wait list for 16 weeks. Children who were randomized to the wait list are offered
      SSD at Week 16. Children randomized to SSD are followed for 9 months to assess the durability
      of gains during the first 16 weeks.
    

Detailed description: 
      This project is designed to evaluate the acceptability and initial efficacy of a structured
      group treatment intervention for enhancing social behavior in 40 children with autism
      spectrum disorders (ASDs). An important long-term goal of this project was to develop a model
      for delivery of social skills training that could be tested in a larger trial and ultimately
      exported to schools and community settings. To accomplish these aims, we designed a
      randomized clinical trial to evaluate a structured social skills program for school age
      children with pervasive developmental disorders (PDDs)compared to a Wait List control group.
      Specific aims included gathering preliminary evidence on the efficacy of the intervention on
      various parent measures of behavior, as well as an assessment of overall social functioning
      by an independent rater who would be blind to treatment assignment. The Social Skills
      Development program uses semi-structured activities and peer tutors to promote interpersanal
      skills. To evaluate acceptability of the program, we planned to track attendance, attrition
      and parent satisfaction in the trial. Finally, to evaluate the durability of gains achieved
      during the Social Skills Development program, we re-assessed the subjects initially
      randomized to the active treatment group at 9 months post-treatment.
    

Intervention name(s): Social Skills Training
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single
Primary purpose: Treatment
Keywords: autism; pervasive developmental disorders; social skills intervention
Determining the Depth of Endotracheal Tube Insertion
Condition: Endotracheal Intubation; Individualized Depth of Endotracheal Intubation
Study type: Observational

Summary: 
      1. Airway length from the medial incisor to carina is divided into four segments ; the
           length from medial incisor to mouth angle, mouth angle to epiglottis, epiglottis to
           vocal cords and vocal cords to carina.

        2. Determining the mean length of each segments with the direct laryngoscope,
           videolaryngoscope and fiberoptic bronchoscope at the time of endotracheal intubation.

        3. Making a new formula to determine the proper individualized depth of intubation on the
           basis of the length of segments

        4. Virtual experiment : comparing the new formula with conventional method of determining
           the depth of endotracheal intubation
    


Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients who are taking operation in the university hospital
A Multiple Dose Study Of PF-04620110 In Type 2 Diabetes Patients
Condition: Type 2 Diabetes Patients
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      PF-04620110 is a novel compound proposed for the treatment of Type 2 diabetes mellitus. The
      primary purpose of this trial is to evaluate the safety and tolerability, and
      pharmacodynamics, of multiple oral doses of PF-04620110 in T2DM patients.
    


Intervention name(s): PF-04620110; PF-04620110; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 5 mg of PF-04620110 given once daily; 2.5 mg of PF-04620110 given twice daily; Matching placebo giving for 4 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: multiple dose study in type 2 diabetes patients
Effect of Plant Stanols on Cholesterol Absorption
Condition: Hypercholesterolemia
MeSH terms: Hypercholesterolemia
Study type: Interventional
Phase: Phase 4

Summary: 
      This study aims to measure the effect of three different doses of plant stanols in margarine
      on the cholesterol absorption efficiency in subjects with mildly to moderately increased
      serum LDL cholesterol concentrations
    

Detailed description: 
      Serum cholesterol lowering effect of plant sterols is well established and it is also known
      that plant stanols inhibit the absorption of cholesterol. However, there is lack of
      dose-response studies directly measuring the cholesterol absorption efficiency during
      prolonged consumption of plant stanols. Therefore this study aims to measure the cholesterol
      absorption efficiency at different plant stanol consumption levels using a stable isotope
      tracer method.

      Subjects will be randomized in their study groups that consume 20 g of margarine with
      different doses of plants stanols (0.8, 1.6 and 2.0g) based on cholesterol absorption
      efficiency at screening (high and low absorbers randomised separately). Cholesterol
      absorption test with cholesterol tracer will be conducted twice: at baseline and after 2-3
      weeks margarine consumption period.

      Cholesterol absorption efficiency will also be examined by indirect method i.e. by following
      the concentrations of serum cholesterol precursors and plant sterols in blood. In addition
      serum total, LDL and HDL cholesterol and triglycerides are followed.
    

Intervention name(s): plant stanol consumption
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: plant sterols; plant stanols; cholesterol absorption
Measuring Single-Serving Grain Intake
Condition: Healthy Volunteers
Study type: Interventional

Summary: 
      The primary objective of this study is to identify markers of a single meal of whole grain
      oat and whole grain wheat intake in humans.
    

Detailed description: 
      The aim of this study is to identify compounds that are found in blood and urine and are
      derived from a single meal of whole grain oat or whole grain wheat intake so that
      epidemiological studies can be conducted to provide more accurate associations between whole
      grain intake and health.
    

Intervention name(s): Whole grain oats; Whole grain wheat
Intervention type(s): Other; Other
Intervention description(s): A meal containing whole grain oats; A meal containing whole grain wheat
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Other
Acute Effect of Static Stretching and Pilates Stretching on the Muscle Strength
Condition: Muscle Strength; Muscle Strength Dynamometer
Study type: Interventional

Summary: 
      Introduction: Studies have shown that static stretching performed immediately before strength
      exercises impairs performance. However, unlike static stretching, dynamic stretching
      performed immediately before muscular strength exercises does not seem to result in worse
      performance, and in some cases may even provide greater strength performance. Still, the
      literature is controversial and inconclusive to date.

      Objective: To verify the acute effect of static stretching versus dynamic stretching on the
      muscle strength of young university students.

      Methods: The sample will consist of 102 physically active young university students, of both
      sexes, aged between 18 and 25 years old, subdivided into three groups: Group 1 - static
      stretching; Group 2 - dynamic stretching; and Group 3 - control. Everyone will undergo
      assessment of the isokinetic peak torque of the knee extensor and flexor muscles at 60º/s and
      180º/s in the dominant lower limb. Next, the experimental groups (Groups 1 and 2) will
      perform static or dynamic stretching exercises for the quadriceps and hamstring muscles,
      while the control group will not perform any activity. Finally, everyone will undergo muscle
      strength assessment again according to the same procedures used initially. Analysis of
      covariance (ANCOVA) will be used to compare groups, with data from the initial assessment as
      adjustment covariates.
    


Intervention name(s): Static stretching; Pilates stretching
Intervention type(s): Other; Other
Intervention description(s): Stretching exercises performed by maintaining the point of muscular discomfort without changing position for a certain period of time.; Stretching exercises performed dynamically, following the six basic principles of Pilates: concentration, control, center, precision, breathing and fluidity.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Bioequivalence Study Between a 4-mg Dose of Fine Granules of Perampanel and a 4-mg Tablet of Perampanel in Healthy Japanese Subjects
Condition: Healthy Participants
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will be conducted to demonstrate the bioequivalence between a single 4 milligram
      (mg) dose of fine granules of perampanel and a single 4 mg tablet of perampanel.
    


Intervention name(s): Perampanel; Perampanel
Intervention type(s): Drug; Drug
Intervention description(s): Single oral dose of 1 x 4-mg perampanel tablet; Single 4-mg dose of perampanel fine granules
Other intervention name(s): E2007; E2007
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Perampanel; Bioequivalence; fine granules; E2007; Japanese
Inspiratory Muscle Training and Physical Fitness in Children With Down Syndrome Randomized Control Trial
Condition: Down Syndrome
MeSH terms: Down Syndrome; Syndrome
Study type: Interventional

Summary: 
      The purpose of this study is to investigate the effect of inspiratory muscle training on
      physical fitness in Down syndrome children. Twenty Down syndrome children from both genders
      ranged in age chronologically from seven to ten years will be selected to participate in this
      study. Selection of the study sample and evaluation of physical fitness improvement as well
      as Inspiratory Muscle training will be conducted in the Down Syndrome Charitable Association
      (DSCA), Riyadh City.

      The study sample will be divided randomly into two equal groups of (A & B). All the children
      participated in the current study will receive 30 minutes of treatment session of aerobic
      exercise, group B will receive first 30 minutes of IMT then take a period time of rest about
      30 minutes before starting the aerobic exercise. Exercise frequency three times per week for
      a period of three successive months.

      The Body mass index (BMI) of each participated child will be determined by measuring weight/
      Kg and height/ m2 using Electronic weight and height scale to include BMI ≥ 29 Kg/ m2 to
      exclude the obese children. Also using Six Minute Walk Test (6MWT) for measuring the aerobic
      capacity and Pulse Oxymeter for measuring pulse rate and Oxygen saturation. In addition, The
      Gio Digital pressure gauge will be used to assess Respiratory Muscle Strength of children by
      determining the Maximal Inspiratory (MIP) and Expiratory Pressure (MEP) which used to detect
      the inspiratory training intensity and reflect the improvement in respiratory muscle strength
      after training program. Brockport Physical Fitness Test (BPFT) will be used to measure
      physical fitness of the participated children. The participated children will be assessed
      before and after three successive months .

      The obtained results of this study will measure Maximal Inspiratory (MIP) and Expiratory
      Pressure (MEP), Aerobic capacity, Musculoskeletal Function and Maximum Heart Rate (HR Max.)
      to determine the significant improvement of participated children
    


Intervention name(s): aerobic exercise training, inspiratory muscle training
Intervention type(s): Device
Intervention description(s): All participants received 30 min of aerobic exercise training thrice per week for a period of 12 weeks, whereas the group B received an additional 30 min of IMT before each aerobic exercise session.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment