Glycolic Acid Plus Salicylic Acid in Treatment of Plane Wart
Condition: Plane Wart
MeSH terms: Warts
Study type: Interventional

Summary: 
      To determine clinical efficacy of glycolic acid 15%plus salicylic acid 2% gel in treatment of
      Plane wart .
    

Detailed description: 
      Warts are typically small, rough, hard growths that are similar in color to the rest of the
      skin. They typically asymptomatic , except when on the bottom of the feet, where they may be
      painful While they usually occur on the hands and feet, they can also affect other locations
      One or many warts may appear They are not cancerous .

      Warts are caused by infection with human papillomavirus(HPV). Factors that increase the risk
      include use of public showers, working with meat, eczema and a weak immune system. The virus
      is believed to enter the body through skin that has been damaged slightly.

      Warts are classified to common wart, plane wart, plantar wart, genital wart. Plane warts are
      circumscribed papules with hyperkeratotic surfaces that can occur singly or in groups. In
      these types of warts, the human papilloma virus (HPV) has been shown to infect the
      keratinocyte. Although no viral subtype is absolute, typically the infection is with HPV
      types 3, 10, 28, and 41 These warts are small in size (1-5mm), flat, or slightly elevated
      lesions. Plane viral warts typically present as skin-colored or light brownish,papules on the
      face, beard area, or on the back of the hands, and primarily affect children.

      Plane warts can greatly affect a patient's quality of life, and their persistence or
      recurrence cause frustration.

      Their evolution is variable, and although two thirds of cases regress spontaneously in the
      course of two years due to immunological mechanism

      The following therapies have been used in the treatment of Plane wart with varying success:
      salicylic acid, cryotherapy, retinoic acid, photodynamic therapy (topical 5-aminolevulinic
      acid photodynamic therapy), pulsed dye laser (PDL), and Candida antigen.

      New medication is a combination of glycolic acid 15% plus salicylic acid 2% gel.

      Glycolic acid has been used in the treatment of Plane wart . It has been suggested that
      alpha-hydroxy acids can produce an authentic exfoliation and dehiscence of the coenocytes
      from recently formed layers of the stratum corneum. Alpha-hydroxy acids also reduce the
      number of desmosomes and tonofilaments.in this study all patients will be instructed to avoid
      sun exposure during the treatment and to use broad spectrum sunscreen The treatment was
      started once daily over the entire face and maintained for two months. A fine layer of face
      gel was applied on the whole surface where the warts were present, avoiding the eyelids and
      lips. In children 7 to 10 years of age, face gel was applied by their parents. Clinical
      controls were performed at Weeks 2, 4, 6, and 8.
    

Intervention name(s): Glycolic Acid Plus Salicylic Acid in Treatment of Plane Wart
Intervention type(s): Other
Intervention description(s): Prior to the procedure, patients will be instructed to avoid sun exposure during the treatment and to use broad spectrum sunscreen The treatment was started once daily over the entire face and maintained for two months. A fine layer of Glycolic Acid Plus Salicylic Acid face gel was applied on the whole surface where the warts were present, avoiding the eyelids and lips. In children 7 to 10 years of age, face gel was applied by their parents. Clinical controls were performed at Weeks 2, 4, 6, and 8.
Intervention MeSH terms: Salicylic Acid; Salicylates; Glycolic acid
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: glycolic acid-Salicylic Acid-Treatment of Plane Wart