Effectiveness of Locally Delivered Morus Alba Gel on Moderate Periodontitis
Condition: Chronic Periodontitis
MeSH terms: Periodontitis; Chronic Periodontitis
Study type: Interventional

Summary: 
      Background: Periodontitis is a chronic inflammatory disease of tooth and supporting tissues
      with clinical signs of bone and connective tissue loss and is mediated by a combination of
      periodontal pathogens and host defense systems. Currently the use of herbal products in
      dentistry is increasing due to their easy availability, low cost and lesser side effects. One
      such herbal plant is Morus alba which is known to possess medicinal properties. Therefore the
      present study was conducted to determine the clinical effectiveness of subgingivally
      delivered Morus alba gel incorporated into polaxamers vehicle for its controlled release on
      periodontal pocket in adjunct to scaling and root planing for treatment of moderate
      periodontitis patients.

      Methods: one hundred eighty patients with chronic periodontitis having pocket depth of ≥5 mm
      in atleast two different teeth were treated by full-mouth scaling and root planning (SRP) and
      curettage. They were randomly assigned into one of the three groups with 60 in each group:
      Group 1: Chlorhexidine Sol-gel was applied at baseline, 15 and 30 days. Group 2: Morus alba
      Sol-gel was applied at baseline, 15 and 30 days. Grpup 3: Placebo gel was applied at
      baseline, 15 and 30 days. Plaque index (PI) (Silness and Loe), Gingival index (GI) (Loe and
      Silness), Community Periodontal index, Periodontal pocket depth and quantitative analysis
      (anaerobic culture) of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and
      Tannerella forsythia were assessed at baseline and after 45 days.
    

Detailed description: 
      Morus alba is invaluable member of the plant kingdom belonging to the family Moraceae and the
      genus Morus. It is extensively cultivated for leaf yield in sericulture. Morus alba have long
      been used in traditional medicine to improve eyesight, lower blood pressure, prevent
      diabetes, protect the liver, strengthen joints and treat fever. In particular, few studies on
      mulberry fruits have reported its biological activities such as antioxidative and
      anti-inflammatory activities. Even the root bark of has been traditionally used in Asian
      countries for medicinal purposes due to its anti-inflammatory, hypoglycemic, antibacterial
      activities. LD50 of extracts of Morus Alba leaves was found to be above 2000 mg/kg which is
      safe to be used in human beings. Therefore, in the present study the Morus alba leaves has
      been used in the gel preparation and its effectiveness is assessed against periodontal
      microorganisms.
    

Intervention name(s): Chlorhexidine gel; Morus alba gel; Placebo
Intervention type(s): Other; Other; Other
Intervention description(s): 0.1 ml of Chlorhexidine gel was administered into the periodontal pocket; 0.1 ml of Morus alba gel was administered into the periodontal pocket; 0.1 ml of Placebo gel was administered into the periodontal pocket
Intervention MeSH terms: Chlorhexidine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Chlorhexidine gluconate; Morus alba; Microbiology; Gel; Root planing