bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Different Flow Anesthesia on Atelectasis
Condition: Atelectasis; Due to Anesthesia; General Anesthesia; Low- Flow Anesthesia; Minimal Flow Anesthesia
MeSH terms: Pulmonary Atelectasis
Study type: Observational

Summary: 
      Evaluation of atelectasis that may be caused by different flow rate anesthesia applications
      during the operation with lung ultrasound score.
    


Intervention name(s): Lung Ultrasound Score
Intervention type(s): Procedure
Intervention description(s): Measuring the atelectasis area by ultrasound guidance from 12 different regions of the lung
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        ASA I-II septoplasty and rhinoplasty patients aged 18-65 years
      
Keywords: Lung Ultrasound Score; Minimal Flow Anesthesia; Atelectasis
Development and Assessment of Feasibility of Non-invasive Multiple Sensor Hypo-Sense as a Tool for Detection of Hypoglycemia
Condition: Type 1 Diabetes; Nocturnal Hypoglycemia
MeSH terms: Diabetes Mellitus, Type 1; Hypoglycemia
Study type: Interventional

Summary: 
      Hypo Sense is a non- invasive method for detection of hypoglycemia. The Hypo Sense combines
      an array of non-invasive sensors which monitors the patient's physiological parameters (heart
      & respiration rate, perspiration, skin temperature and arm motion) designed as a wrist watch
      device.

      The Hypo sense is intended for monitoring symptoms of hypoglycemia in diabetic patients in
      hospital environment among type 1 and type 2 diabetes adults as an adjunctive device to
      reference methods

      The proposed study will be consisting of two main segments:

      The primary aim of segment 1 of the study is data collection and calibration of the Hypo
      Sense sensor prototype compared to standard invasive reference glucometer.

      The primary aim of segment 2 of the study is to validate the Hypo Sense prototype performance
      in detecting hypoglycemic events.

      During the first segment of the study we intend to collect in parallel measurements of blood
      glucose using reference method (capillary glucometer) and continuous data generated by the
      non- invasive study device during approximately 4 hours, in which a hypoglycemic event will
      be induced.

      The reference and study device data will be analyzed using multivariate regression model to
      formulate a calibration algorithm model. This model will translate the set of the
      physiological recorded parameters into detection of hypoglycemic events.

      During the second segment of the study we intend to evaluate the validity of the Hypo Sense
      sensor ability to detect hypoglycemic events compared to standard invasive reference method
      (capillary glucometer).
    


Intervention name(s): Hypo-Sense (non invasive sensor)
Intervention type(s): Device
Intervention description(s): Parallel measurements of capillary blood glucose using reference methods (both capillary glucometer and continuous sensor) and data generated by the non- invasive study device during approximately 4 hours, in which a hypoglycemic event will be induced.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Type 1 Diabetes; Hypoglycemia detection; Non-invasive sensor; Nocturnal hypoglycemia
The Effect of HIIT in Handling Obesity in Children
Condition: High Intensity Interval Training; Child Obesity
MeSH terms: Obesity; Pediatric Obesity
Study type: Interventional

Summary: 
      In this study the investigators wish to investigate whether a short duration High-intensity
      Interval Training(HIT) is superior to a moderate activity training modus with regards to
      improving weight-loss, Blood pressure and sleep quality in severely obese children and
      adolescents also receiving a multidisciplinary treatment regime.
    

Detailed description: 
      Prevalence of overweight and obesity among children and adolescents are rapidly rising
      worldwide. Despite the alarming situation, great confusion of how to tackle obesity persists
      for two main reasons: the condition is much more complex than initially thought, and many
      aspects regarding pathophysiology remain unrevealed, leading to an insufficient understanding
      of the disorder. Childhood obesity is, strongly associated with numerous disorders e.g.
      hypertension, insuline resistance, sleep apnea, depression and many more.

      High intensity Interval Training has proven beneficial in treating obesity and comorbidities
      in adults. The investigators wish to investigate whether twelve weeks of High-intensity
      Interval Training(HIT) twice a week is superior to a moderate activity training modus for
      same period of time with regards to improving weight loss, blood pressure and sleep quality,
      in severely obese children and adolescents also receiving a multidisciplinary treatment
      regime. Participants are severely obese children and adolescents referred to the outpatient
      Clinic for treatment of obesity. Participants are randomizid to either moderate training or
      HIIT. Antropometric measures, blood pressure and sleep quality as measured by sensewear
      armbands, are done at baseline, after the twelve weeks of training and again one year after
      inclusion. Participants are monitored with pulse monitors during training sessions to
      register if training goals are obtained.
    

Intervention name(s): HIIT; Moderate training
Intervention type(s): Behavioral; Behavioral
Intervention description(s): High Intensity Interval Training for twelve weeks; Moderate training for twelve weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized Controlled trial
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Child Obesity; Adolescents; High Intensity Interval Training; Moderate training
1.2% Rosuvastatin Subgingivally Delivered In Chronic Periodontitis With Type 2 Diabetes Mellitus
Condition: Chronic Periodontitis; Type2 Diabetes
MeSH terms: Periodontitis; Chronic Periodontitis; Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      The purpose of the present study was to evaluate the effects of subgingival delivery of 1.2%
      Rosuvastatin (RSV) gel as an adjunct to scaling and root planing in chronic periodontitis
      (CP) with Type 2 diabetes mellitus patients.
    

Detailed description: 
      Background: The purpose of this double-masked, randomized, controlled clinical trial was to
      evaluate the effects of subgingival delivery of 1.2% Rosuvastatin gel as an adjunct to
      scaling and root planing (SRP) on clinical and radiographic parameters and compare this
      method with SRP plus placebo gel alone in chronic periodontitis (CP) with type 2 DM patients.

      Methods: Eighty CP patients with type 2 DM are included in this study. They were divided into
      two groups: 1) SRP + 1.2% Rosuvastatin gel (RSV group); 2) SRP + Placebo gel (Placebo group).
      At baseline, 3, 6 and 9 months after treatment, clinical measurements, including plaque index
      (PI), modified sulcus bleeding index (mSBI), probing depth (PD), clinical attachment level
      (CAL) and radiographic parameters intrabony defect depth (IBD), percentage change in
      radiographic defect depth reduction (DDR%) were assessed.
    

Intervention name(s): SRP plus Rosuvastatin gel; SRP plus placebo gel
Intervention type(s): Drug; Drug
Intervention description(s): SRP followed by 1.2% Rosuvastatin placement into intrabony defect; SRP followed by placebo gel placement into intrabony defect
Intervention MeSH terms: Rosuvastatin Calcium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Gastrointestinal Tolerance and Safety of an Infant Formula Containing Prebiotics, Probiotics and Postbiotics.
Condition: Gastrointestinal Tolerance
Study type: Interventional

Summary: 
      A study to investigate the gastrointestinal tolerance and safety of a new formula containing
      prebiotics, probiotics and postbiotics.
    


Intervention name(s): Infant formula containing prebiotics, probiotics and postbiotics
Intervention type(s): Other
Intervention description(s): Infant formula containing prebiotics, probiotics and postbiotics
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
High-activity Natural Killer Immunotherapy for Small Metastases of Melanoma
Condition: Melanoma
MeSH terms: Melanoma
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The aim of this study is the safety and efficacy of high-activity natural killer
      immunotherapy to small metastases of melanoma.
    

Detailed description: 
      By enrolling patients with small metastases of melanoma adapted to enrolled criteria, this
      study will document for the first time the safety and the short and long term efficacy of
      high-activity natural killer cells.

      The safety will be evaluated by statistics of adverse reactions. The efficacy will be
      evaluated according to local relief degree, progress free survival (PFS) and overall survival
      (OS).
    

Intervention name(s): High-activity natural killer
Intervention type(s): Biological
Intervention description(s): Each treatment: 8-10 billion cells in all, transfuion in 3 times, i.v.
Other intervention name(s): HANK cell
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Metastatic Melanoma; High-activity natural killer
Study of Docosahexanoic Acid in Patients With Cystic Fibrosis (CF)
Condition: Cystic Fibrosis
MeSH terms: Cystic Fibrosis; Fibrosis
Study type: Interventional
Phase: Phase 2

Summary: 
      Patients with Cystic Fibrosis have increased oxidative stress and impaired antioxidant
      systems. Under certain conditions, docosahexaenoic acid (DHA) intake may have a favorable
      role in reducing redox status.

      In this randomized, double-blind, cross-over study, DHA (Pro-Mind) and placebo (sunflower
      oil) capsules, will be given, daily to 10 patients, 5 mg/kg for 2 weeks then 10 mg/kg for the
      next 2 weeks. Biomarkers of lipid peroxidation and vitamin E levels will be measured. Plasma
      and platelet lipid compositions will be determined.
    


Intervention name(s): Docosahexaenoic acid; Sunflower Oil
Intervention type(s): Drug; Drug
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
The Pharmacokinetics Study of Concentrated Herbal Formula and Traditional Herbal Decoctions in Humans
Condition: Healthy
Study type: Observational

Summary: 
      The purpose of this study is to investigate the pharmacokinetics in humans of San Huang Xie
      Jin Tang (SHXJT) and evaluate the bioequivalence between herbal concentrate and traditional
      decoction.
    


Intervention name(s): San Huang Xie Jin Tang
Intervention type(s): Drug
Observational model: Defined Population
Time perspective: Other
Keywords: Pharmacokinetics; Bioavailability; Therapeutic Equivalency
Sexual Absorption of Vaginal Progesterone
Condition: Infertility; Pregnancy
MeSH terms: Infertility
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to determine if sexual intercourse lowers serum progesterone in
      women using vaginal progesterone gel (Crinone®), and increases serum progesterone in their
      male sexual partners. We hypothesize, based on previous estrogen studies done by our group,
      that intercourse will interfere with absorption of vaginal progesterone.
    

Detailed description: 
      The effects of intercourse on the absorption of vaginal progesterone for the female user and
      her sexual partner have not been studied. However, a previous study performed by our group
      found that intercourse lowered the absorption of vaginal estrogen cream in women, and men
      absorbed a small but statistically significant amount of estradiol during intercourse.
      Vaginal progesterone gel may be used by women for several clinical indications, and if
      intercourse alters the absorption and distribution of vaginal progesterone, clinical outcomes
      may be compromised. If intercourse lowers absorption, the efficacy of the treatment could be
      reduced. If intercourse enhances absorption, side effects may be increased. Also, if the male
      sexual partner absorbs vaginal progesterone, undesirable side effects may occur.
    

Intervention name(s): Crinone vaginal progesterone gel; Placebo vaginal gel
Intervention type(s): Drug; Drug
Intervention description(s): Crinone vaginal progesterone gel is inserted in the female vaginal using the pre-filled applicator.; Placebo vaginal gel is inserted in the female vagina using the pre-filled applicator.
Intervention MeSH terms: Progesterone
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Initial assignment randomized, then crossed over to the other treatment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Diagnostic
Keywords: Assisted reproductive technology; Infertility; Progesterone; Vaginal gel; Luteal-phase support
A Study to Evaluate the Effect of Multiple Oral Doses of JNJ-42847922 on the Steady-state Pharmacokinetics of an Oral Contraceptive Containing Ethinyl Estradiol and Levonorgestrel in Healthy Female Adult Participants
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the effect of multiple 40 milligram (mg) doses of
      JNJ-42847922 on the steady state pharmacokinetics (PK) of multiple doses of a combination
      oral contraceptive (OC) containing ethinyl estradiol (EE) and levonorgestrel (LN) in healthy
      female adult partcipants.
    


Intervention name(s): Ethinyl Estradiol + Levonorgestrel; JNJ-42847922
Intervention type(s): Drug; Drug
Intervention description(s): Participants will receive one OC tablet containing EE 0.03 mg and LN 0.15 mg once daily on Days 1 to 21 in cycles 1 and 2.; Participants will receive 40 mg of JNJ-42847922 once daily on Days 14 to 21 in cycle 2.
Other intervention name(s): Microgynon 30
Intervention MeSH terms: Levonorgestrel; Ethinyl Estradiol; Ethinyl estradiol, levonorgestrel drug combination; Estradiol
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Three-Dimensional Printed Customized Titanium Mesh for Mandibular Augmentation
Condition: Alveolar Bone Loss
MeSH terms: Alveolar Bone Loss
Study type: Interventional

Summary: 
      Completely or partially edentulous patients suffer from resorption of the alveolar bone, they
      always seek rehabilitation which becomes challenging. Alveolar ridge augmentation is widely
      done now to offer these patients functional and esthetic restoration. Many techniques have
      been proposed to obtain good results of ridge augmentation. Titanium Mesh (TiMe) is widely
      used, also digital and computer-guided surgery now plays an important role to improve the
      techniques and results in ridge augmentation procedures.
    


Intervention name(s): 3D customized Titanium Mesh (Study); Conventional ridge augmentation (Control)
Intervention type(s): Procedure; Procedure
Intervention description(s): approach for planning and augmenting atrophic posterior mandibular ridge using a pre-customized TiMe on a 3D model. The 3D surgical model will be virtually created from a cone-beam computed tomography (CBCT) and printed using Fused deposition modeling (FDM) machine. The 3D model will be then used to contour the TiMe in accordance with the needed amount of augmentation then will be used to help pack and contour the graft material.; the conventional technique of ridge augmentation using Titanium Mesh
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Temporomandibular Dysfunction and Cervical Posture
Condition: Temporomandibular Dysfunction
MeSH terms: Temporomandibular Joint Disorders; Temporomandibular Joint Dysfunction Syndrome
Study type: Observational

Summary: 
      The aim of this research was to determine the existence of a correlation between the degree
      of temporomandibular dysfunction and cervical posture in different occlusal classes in
      adolescents. A cross-section, observational study was carried out, in which 296 adolescents
      took part. For the evaluation, the patients were divided into groups according to the
      presence and severity of the temporomandibular dysfunction, using a questionnaire and
      occlusal Angle classification. The posture analysis was carried out using photogrammetry and
      the software Alcimage® to measure the predefined angle based on the protuberances of the
      Spinous Process of the 7th Cervical Vertebra (C7), Manubrium of the sternum and Mentum
      Vertex.
    

Detailed description: 
      The evaluation of signs and symptoms of TMD was obtained from a Questionnaire (15) which
      includes information regarding difficulties opening the mouth and movement of the mandible,
      pains in the head, nape of the neck, neck or joint regions, noise in the temporomandibular
      joints, and the habit of clenching or grinding the teeth. The questionnaire is comprised of
      10 questions with possible answers of yes (10 points), sometimes (5 points) and no (0
      points). For each question, only one answer can be checked. The total score is used to
      classify the severity of the TMD as severe (70 to 100 points), moderate (45 to 65), mild (20
      to 40) and no dysfunction (0 to 15).

      The clinical (visual) assessment of head posture was conducted using a postural grid. Each
      subject was asked to remain in his or her normal posture, in a standing position. The self
      balance position was used to standardize the posture of each subject, asking them to look
      straight ahead, parallel to the floor, keeping the gaze horizontal
    

Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        adolescents aged between 10 and 20 years. As criteria for inclusion, age group and the
        presence of first permanent molar
      
Keywords: temporomandibular dysfunction; posture
Safety and Gastrointestinal Effects of Intravenous Methylnaltrexone
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 2

Summary: 
      This study evaluates the safety of multiple doses of IV MNTX in normal healthy adults.
    


Intervention name(s): IV Methylnaltrexone
Intervention type(s): Drug
Intervention MeSH terms: Methylnaltrexone
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Influence of Oxytocin on Pair-bonding and Emotion Regulation
Condition: Healthy
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The neuropeptide oxytocin (OXT) has been identified as a key modulator of human social
      behavior and it has been recently shown that OXT also contributes to pair-bonding in men.
      However, it is still elusive whether OXT has similar effects in women. In the present study,
      the investigators examine the effect of intranasal OXT on behavioral ratings of and neural
      responses to the male partner in female participants. In a second experiment, the modulatory
      effect of OXT on emotion regulation is investigated.
    


Intervention name(s): Syntocinon-Spray
Intervention type(s): Drug
Intervention description(s): Intranasal administration of 24 IU Oxytocin
Intervention MeSH terms: Oxytocin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Healthy women
Evaluation of Pneumococcal Vaccine Formulations in Elderly
Condition: Infections, Streptococcal
MeSH terms: Streptococcal Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this observer-blind study is to evaluate the safety, reactogenicity and
      immunogenicity of pneumococcal vaccines in elderly. Subjects will be vaccinated twice with an
      interval of two months.
    


Intervention name(s): Pneumococcal vaccine GSK2189241A; Pneumo 23™
Intervention type(s): Biological; Biological
Intervention description(s): Two doses of 0.5 ml will be administered intramuscularly; one dose at Month 0 and another at Month 2.; One dose of 0.5 ml will be administered intramuscularly at Month 0, and a placebo dose to keep the blinding at Month 2.
Intervention MeSH terms: Heptavalent Pneumococcal Conjugate Vaccine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Streptococcus pneumoniae; pneumococcal vaccine
The Effect of General and Spinal Anesthesia on Neutrophil-to-lymphocyte Ratio
Condition: Anesthesia, General; Anesthesia, Spinal; Umbilical Cord
Study type: Observational

Summary: 
      The aim of the study was to evaluate the effects of anesthetic techniques (general and spinal
      anesthesia) on umbilical cord neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte
      ratio (PLR) and mean platelet volume (MPV) in patients undergoing cesarean section.
    

Detailed description: 
      This study was designed to evaluate the effects of anesthetic techniques (general and spinal
      anesthesia) on umbilical cord NLR, PLR and MPV in patients undergoing cesarean section.

      The primary endpoint was to compare the effects of general and spinal anesthesia on umbilical
      cord NLR. Secondary endpoints were determined the general and spinal anesthesia on routine
      umbilical cord PLR, MPV and newborn Apgar scores at 1st and 5th min.
    

Intervention name(s): General anesthesia; Spinal anesthesia
Intervention type(s): Other; Other
Intervention description(s): Evaluate the effects of general anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.; Evaluate the effects of spinal anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.
Intervention MeSH terms: Anesthetics
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        elective ceserean surgery
      
Keywords: anesthesia; cesarean section; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; mean platelet volume
An Intervention to Promote Active Transport for Short Distance Travel in Older Adolescents
Condition: Transport Behaviour Intervention
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether a theory- and evidence-based intervention
      aiming to promote active transport for short distance travel among older adolescents is
      effective in increasing attitude, subjective norm, self-efficacy, awareness and habit towards
      active transport, and intention to use active transport after obtaining a driving license.
    


Intervention name(s): Active transport lesson; Active transport lesson and Facebook group
Intervention type(s): Other; Other
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Keywords: determinants; active transport; intervention; adolescents