Validation of a German Translation and Cultural Adaptation of the Addenbrooke's Cognitive Examination III
Condition: Neurocognitive Dysfunction
MeSH terms: Cognitive Dysfunction
Study type: Observational

Summary: 
      The aim of the entire project was to perform a translation and cultural adaptation of the
      Addenbrooke's Cognitive Examination - III (ACE-III), adhering to the Translation and Cultural
      Adaptation of Patient Reported Outcomes Measures-Principles of Good Practice, in order to
      make it available to German clinicians.

      Part of the translation process is the cognitive debriefing which will be performed as a
      survey which rates the applicability of every single item as well as of the entire
      Addenbrooke's Cognitive Examination - III tool.
    

Detailed description: 
      The recent demographic developments have drastically increased the importance of developing
      applicable approaches to the diagnostics of dementia and the general evaluation of cognitive
      function. Many different tests were developed to thoroughly evaluate neurocognitive function.

      The Addenbrooke's Cognitive Examination, developed in 2000, was one such tests and has served
      as an open source neurocognitive examination tool ever since. The current version is the
      Addenbrooke's Cognitive Examination III (ACE-III). The aim was to develop a tool that would
      be able to identify dementia in its early stages and also to differentiate between the
      different types of dementia.

      In order to achieve reliable results, cognitive tests should be conducted in a familiar
      language and draw from the cultural background a participant is familiar with. The ACE-III
      and all its predecessors were developed in English and for an English-speaking cultural
      background, not directly applicable to the typical German patient. This made it necessary to
      perform not only a verbatim translation of test contents, but also to appropriately adapt the
      test content to reflect the cultural background of the typical German patient. The
      International Society For Pharmacoeconomics and Outcomes Research (ISPOR) - Task Force for
      Translation and Cultural Adaptation has developed the "Translation and Cultural Adaptation of
      Patient Reported Outcomes Measures-Principles of Good Practice", to ensure a consistent and
      rigorous methodology in the process of translating and adapting patient-reported outcomes
      measures.

      The Principles of Good Practice consist of ten steps:

        1. Preparation

        2. Forward Translation

        3. Reconciliation

        4. Back Translation

        5. Back Translation Review

        6. Harmonization

        7. Cognitive Debriefing

        8. Review of Cognitive Debriefing Results and Finalization

        9. Proofreading

       10. Final Report
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Male and female employees (≥ 18 years of age) of the Department of Anesthesiology and
        Operative Intensive Care Medicine (CCM, CVK), Charité Universitätsmedizin Berlin
        experienced in the field of neurocognitive testing