Comparison of Different Helicobacter Pylori Detection Methods in Patients With Chronic Atrophic Gastritis
Condition: Helicobacter Pylori Infection
MeSH terms: Gastritis; Gastritis, Atrophic
Study type: Interventional

Summary: 
      As we know，Helicobacter pylori is closely related to many gastrointestinal diseases such as
      chronic gastritis, peptic ulcer disease,gastric carcinoma and gastric mucosa-associated
      lymphoid tissue lymphoma，as well as extra-digestive diseases such as urticaria and chronic
      obstructive pulmonary diseases and so on.The diagnosis of H. pylori infection is based on
      invasive methods requiring endoscopy and biopsy(e.g. histology, culture, rapid urease test,
      PCR) or on non-invasive methods (e.g. serology, 13C urea breath test, stool antigen
      test).Histology has the highest specificity among the others,and also allows us to determine
      the underlying disease and perform antibiotic sensitivity testing.Serological tests are
      widely available and more appropriate for epidemiological studies, their main weakness for
      clinical use is low specificity.The 13C urea breath test is the most accurate method in
      patients irrespective of age.Stool antigen testing,as a promising method, is easy to perform,
      and its accuracy may be improved by the use of monoclonal antibodies recently proposed for
      capturing H. pylori antigen in stool specimen.Sensitivity and specificity, usefulness,and
      limitation of tests should be considered for selection of detection methods of H. pylori. Our
      objective is to review the current methods that are used for the detection of H. pylori
      infection among patients with chronic atrophic gastritis.Except that,patients with Hp
      positive will be further treated with 10-day minocycline-based quadruple therapy,to observe
      the efficacy and safety of minocycline-based regimen for H.pylori eradication as a first-line
      therapy.
    

Detailed description: 
      Consecutive outpatients (18 to 70 years), with endoscopically proven chronic atrophic
      gastritis will be enrolled in our study.5 different methods，including histology,13C urea
      breath test,stool antigen test,serological antibody test for H.pylori and serologic test with
      a current infection marker of H.pylori，will be performed to detect H. pylori infection.And
      patients with Hp positive will be further treated with 10-day minocycline-based quadruple
      therapy.Our objective is to compare specificity and sensitivity of the current methods among
      patients with chronic atrophic gastritis,meanwhile,to observe the efficacy and safety of
      minocycline-based regimen for H.pylori eradication as a first-line therapy.
    

Intervention name(s): Histology，13C urea breath test，Stool antigen test，Serological antibody test for H.pylori and Serologic test with a current infection marker of H.pylori; Rabeprazole，Minocycline，Amoxicillin and Colloidal bismuth pectin
Intervention type(s): Diagnostic Test; Drug
Intervention description(s): The above 5 detection methods will be performed in patients who meet the inclusion criteria to detect H. pylori infection; Helicobacter pylori positive patients will be treated with rabeprazole10mg,minocycline 100mg,amoxicillin1000mg,and colloidal bismuth pectin 200mg,all twice daily for 10 days
Intervention MeSH terms: Amoxicillin; Minocycline; Rabeprazole; Bismuth; Antibodies
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic