Studying Genes, Environment, and Prostate Cancer Risk in Patients With or Without Prostate Cancer
Condition: Hereditary Prostate Cancer; Prostate Cancer
MeSH terms: Prostatic Neoplasms
Study type: Observational

Summary: 
      RATIONALE: Gathering information about genetic and environmental factors may help doctors
      learn more about a person's risk for developing prostate cancer.

      PURPOSE: This research project is studying genes, environment, and prostate cancer risk in
      patients with or without prostate cancer.
    

Detailed description: 
      OBJECTIVES:

        -  To determine the association between variation in genes involved in ROS detoxification,
           oxidative stress response, and prostate cancer risk.

        -  To determine the association between fatty acid levels and prostate cancer risk.

      OUTLINE: Probands undergo blood and saliva sample collection for fatty acid, DNA, and
      polymorphism analyses. Archived blood and tissue samples from probands who previously
      participated in Dr. Shannon's Diet and Prostate Cancer Risk study are also analyzed. Medical
      records of probands are reviewed for demographics, history and course of disease, and
      clinical laboratory test results.

      All probands completed the "Genetic Risk Easy Assessment Tool Family History of Cancer" and
      "Diet History and Environmental Risk Factor" questionnaires at baseline. If a proband
      previously participated on our Diet and Prostate Cancer Risk study, he was asked to complete
      the "Changes in Diet, Prescriptions, Supplementals and Herbal Remedies" questionnaire in
      addition to the "Genetic Risk Easy Assessment Tool Family History of Cancer" questionnaire at
      baseline for this study.

      PROJECTED ACCRUAL: A total of 750 participants will be accrued for this study.
    

Intervention name(s): DNA analysis; polymorphism analysis; laboratory biomarker analysis; medical chart review; questionnaire administration; evaluation of cancer risk factors; study of high risk factors
Intervention type(s): Genetic; Genetic; Other; Other; Other; Procedure; Procedure
Intervention description(s): saliva samples will be collected from men (probands) who join the study.; we will genotype DNA samples (buccal) from all probands and conduct a traditional case-control analysis; 10ml blood specimen will be obtained and processed (on probands locally-consented and/or those who have an appointment at the VA in Portland, Oregon) to allow for analyses of erythrocyte fatty acids and future nutrient and DNA analyses; PSA results, prostate biopsy pathology reports and clinician notes related to the biopsy are reviewed for final data analysis; probands are asked to complete questionnaires on 1) family history of cancer, 2) diet history over the past year, 3) employment environment and risk factors and/or 4) changes to diet, medications since enrollment in originating case control study; pathology reports will be reviewed for probands whose prostate biopsies reveal cancer; these factors will be evaluated for cancer risk factors; prostate biopsy pathology reports will be reviewed for high risk factors
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        1. Recontacting previously recruited Diet and Prostate Cancer Risk study participants;
             cases and biopsy negative controls

          2. Prospective recruitment of men referred for a prostate biopsy to the Portland VA
             urology clinic

          3. Men from the public sector who learn about our study and would like to participate
      
Biospecimen description: 
      10ml blood specimen drawn from probands consented in person at the Portland VA; saliva
      samples from all consented probands (N = 748).
    
Keywords: hereditary prostate cancer; prostate cancer