Gait and Balance Parameters Before and After Parathyroidectomy in Patients With Primary Hyperparathyroidism
Condition: Primary Hyperparathyroidism
MeSH terms: Hyperparathyroidism; Hyperparathyroidism, Primary
Study type: Interventional

Summary: 
      This study will evaluate how Quadriceps Femoris muscle fatigue protocol affect the
      spatio-temporal gait parameters, gait symmetry and balance in individuals with primary
      hyperparathyroidism before and after parathyroidectomy. Study group will consist of 20
      subjects with primary hyperparathyroidism (PHPT) and control group will consist of 20 healthy
      subjects.
    

Detailed description: 
      Parathyroid hormone, released from the parathyroid gland, plays an important role in keeping
      the ionized calcium in between the reference values in body. Precise control of ionized
      calcium is particularly necessary to ensure the optimal function of physiological processes
      such as providing intracellular signaling, performing neuromuscular functions and bone
      metabolism. When there is a decrease in the level of ionized calcium in the systemic
      circulation due to any reason, increased calcium concentration is maintained as a result of
      the increased absorption of calcium from the kidneys, bones and intestines into the blood via
      increased parathyroid hormone. An error caused by any of the components in this regulatory
      system may cause excessive parathyroid hormone release, causing primary, secondary or
      tertiary hyperparathyroidism. Primary hyperparathyroidism (PHPT) is a common endocrinological
      disorder, which is characterized by excessive release of parathyroid hormone, resulting in a
      defect in the regulation of calcium metabolism. PHPT, is the third most common endocrine
      disease and is the most common cause of hypercalcemia. Today, PHPT is approximately
      0.25-0.66% of the population and it is seen as 3: 1 times more common in women than men.
      While the incidence of the disease increases with age, it increases dramatically after 50
      years of age. The clinical presentation of PHPT ranges from asymptomatic disease to the
      classical symptomatic disease of renal and / or musculoskeletal complications. Low plasma 25
      Hydroxyvitamin D level; bone mineral density, muscle strength, preservation of postural
      stability and functional performance of the musculoskeletal functions such as disruption
      caused by the person's walking and balance activities are adversely affected.In addition,
      fatigue, pain, and body mass index, as a result of the increase in the functional capacity of
      the person is seriously reduced quality of life and psychosocial status is adversely
      affected. Although there are studies related to bone mineral density, muscle strength and
      function, instability, fatigue, etc., which are secondary to PHPT and cause a significant
      decrease in functional capacity, there is no study to investigate the effect of M. quadriceps
      Femoris ,which has a key role in the evaluation of functional capacity, muscle fatigue on the
      gait and balance parameters in the pre and post-treatment period in the literature. The aim
      of this case-control study is to investigate the effect of Quadriceps Femoris muscle fatigue
      protocol on gait, gait symmetry and balance parameters before and after parathyroidectomy in
      patients PHPT and to compare that parameters of these individuals with healthy controls with
      similar demographic characteristics that included in the control group.
    

Intervention name(s): gait analysis
Intervention type(s): Diagnostic Test
Intervention description(s): Computerized gait analysis system will use to evaluate spatio-temporal gait parameters
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Screening
Keywords: Primary Hyperparathyroidism; Spatio-Temporal Parameters of Gait; Gait Symmetry; Balance