bioihbjkbjnl/mcl2 huggingface dataset:
An Intervention Targeting Daily Adaptive Skills Through Executive Function Training for Adults With ASD
Condition: Autism Spectrum Disorder; High-functioning Autism; Autism
MeSH terms: Autistic Disorder; Autism Spectrum Disorder; Child Development Disorders, Pervasive
Study type: Interventional

Summary: 
      The current study is a single group pilot study of a novel intervention program which targets
      improvements in executive functions and adaptive skills in transition age young adults with
      high-functioning autism spectrum disorder. The main aim of the study is to test the
      effectiveness of the intervention using a pretest-posttest comparison. It is hypothesised
      that there will be an increase in executive functions and adaptive skills after the
      intervention.
    

Detailed description: 
      The participants engaged in a 10-week group-based intervention program which aims to improve
      daily adaptive skills based on executive functions and help the transition into adulthood in
      young adults with ASD. Before and after the intervention, the participants and their parents
      completed questionnaires that measure executive functions and adaptive skills, and the
      participants additionally completed an assessment of social adaptive skills. The differences
      between pre- and post-intervention scores of the outcome measures were analyzed using
      Wilcoxon signed-rank tests to evaluate the effect of the program.
    

Intervention name(s): Skills for Adaptive Functioning through Executive training (SAFE; tentative title)
Intervention type(s): Behavioral
Intervention description(s): An intervention program to improve adaptive skills and executive functions in young adults with high-functioning autism spectrum disorder was administered weekly for 10 weeks to the participants. The participants also completed pre-, mid- and post-intervention assessments.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Autism Spectrum Disorder; High-functioning Autism; Autism; Executive Function; Intervention
Effect of Integrated Neuromuscular Training on Medium Fast Bowler in Cricket
Condition: Sports Physical Therapy
Study type: Interventional

Summary: 
      Effect of Integrated Neuromuscular Training on Explosive Strength, Speed and Endurance of
      Medium Fast Bowler in Cricket
    

Detailed description: 
      Integrated neuromuscular training (INT) is a combination of functional movement training and
      speciﬁc strength, balance, speed, sensitivity, and isometric training, which aims to evaluate
      and prevent sports injury and improve sports performance. Neuromuscular control defects are
      mainly manifested as decreases in muscle strength, explosive power, or abnormal activation
      patterns. INT is deﬁned as a conceptual training program that incorporates general (e.g.,
      fundamental movements) and speciﬁc strength and conditioning tasks (e.g., resistance,
      balance, agility, plyometric) to improve injury resilience and to enhance sporting and motor
      skill performance. The majority of studies in youth examining neuromuscular training
      strategies to improve performance and injury prevention include multiple components (for
      example, balance, strength, plyometric, agility, speed, coordination. INT sessions are
      characterized by short bursts of physical activity interspersed with brief rest periods.

      the purpose of this study is to find the effect of integrated neuromuscular training on
      explosive strength, speed and endurance of medium fast bowler in cricket
    

Intervention name(s): Integrated neuromuscular training program group; General fitness exercises program group
Intervention type(s): Other; Other
Intervention description(s): Integrated neuromuscular training program group will do plyometric training, speed and sensitivity training, resistance training for 3 days in a week and total for eight weeks.; General fitness exercises program group will do general fitness exercise for 3 days in a week and total for eight weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Sports Rehabilitation; Integrated Neuromuscular Training; Speed; Endurance; Explosive strength; Fast bowler; Cricket
A Study in Healthy Men to Test How Different Doses of BI 1815368 Are Tolerated and How BI 1815368 is Taken up in the Body With or Without Food
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      Single-rising dose (SRD) part The main objectives of the SRD part of this trial are to
      investigate safety, tolerability and pharmacokinetics (PK) of BI 1815368 in healthy male
      subjects following oral administration of single rising doses.

      Bioavailability (BA) part The main objective of the BA part is to investigate the relative
      bioavailability of a tablet formulation versus oral solution and to assess the influence of
      food on the relative bioavailability of the tablet formulation.
    


Intervention name(s): BI 1815368 formulation 1; Placebo; BI 1815368 formulation 2
Intervention type(s): Drug; Drug; Drug
Intervention description(s): BI 1815368 formulation 1; Placebo; BI 1815368 formulation 2
Allocation: Randomized
Intervention model: Sequential Assignment
Intervention model description: This study has 2 parts: a single rising dose (SRD) part and a bioavailability (BA) part. For the SRD part the intervention study model is sequential, while for the BA part the intervention study model is crossover.
Masking: Single (Participant)
Primary purpose: Treatment
Late Night Snack and Insulin Glargine
Condition: Type 1 Diabetes; Hypoglycemia
MeSH terms: Diabetes Mellitus, Type 1; Hypoglycemia
Study type: Interventional

Summary: 
      Twenty patient with Type 1 diabetes, using insulin glargine as basal insulin, participated in
      a prospective, controlled crossover trial comparing blood glucose profiles over two 24 h
      periods with and without a late night snack (a slice of rye bread, 20 g carbohydrates, at 10
      p.m.), in randomized order. The main endpoint was the number of hypoglycemic episodes with a
      confirmed laboratory blood glucose ≤ 50 mg/dl between 10 p.m. and 8 p.m. the following day.
      Secondary endpoint was the blood glucose profile during this period.
    

Detailed description: 
      The order of studies (with and without a late night snack) was determined by randomization.
      Study-related procedures started at 6 p.m. (standard blood glucose profiles with
      determinations at 6, 8, and 10 p.m, at midnight, at 2, 4, 6:45, 8:45 a.m., and at noon and 2,
      6, and 8 p.m. of the following day). At 10 p.m. a late night snack (one slice of whole meal
      rye bread containing approximately 20 g of carbohydrate) was eaten or no nutrients were
      consumed, as determined by the randomization protocol. After one day without study-related
      activities, the study was repeated with the complementary protocol (crossover design).
      Patients were instructed to use fast-acting insulin to correct hyperglycemia three times per
      day (before major meals) or to take in additional carbohydrate when symptomatic or chemical
      hypoglycemia was noted. They were asked not to perform strenuous exercise beyond their normal
      daily activities.
    

Intervention name(s): Late night snack; No late night snack
Intervention type(s): Dietary Supplement; Other
Intervention description(s): The late night snack was one slice of whole meal rye bread containing approximately 20 g of carbohydrate.; Patient consumed no nutrients at late night.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Hypoglycemia; Type 1 diabetes
A Study of Recombinant Human Erythropoietin in Anemic Cancer Patients Undergoing Chemotherapy
Condition: Chemotherapy Induced Anemia
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to evaluate the effectiveness and safety of recombinant human
      erythropoietin in anemic cancer patients undergoing chemotherapy.
    


Intervention name(s): recombinant human erythropoietin; recombinant human erythropoietin
Intervention type(s): Drug; Drug
Intervention description(s): 3600IU(s.c.)/week for 7 weeks and 54000IU(s.c.)/week for 5 weeks; 36000IU(s.c.)/week for 12 weeks
Intervention MeSH terms: Epoetin Alfa
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Short-term Cardiovascular Benefits of Wearing Particulate-filtering Respirators
Condition: Autonomic Nervous System Imbalance; Blood Pressure; Inflammation; Vasoconstriction; Blood Coagulation Disorders
MeSH terms: Hemostatic Disorders; Blood Coagulation Disorders; Inflammation
Study type: Interventional

Summary: 
      An intervention study to assess the short-term cardiovascular effects of reducing personal
      air pollution exposure by wearing particulate filtering respirators.
    

Detailed description: 
      A group of healthy adult college students fulfilling the recruitment criteria were randomly
      divided into two sub-groups. One sub-group weared the particulate filtering respirators for 2
      continuous days during which the respirator was required to wear as much as possible both
      indoor and outdoor. The other group acted as normal at the same time. The measurements on
      health effects including heart rate varibility, blood pressure, circulating biomarkers as
      well as the ambient air pollution were performed in both groups during the intervention
      period. After a 3-week rest period,the two groups interchanged their roles of wearing the
      respirator or not. The same measurements of both health effects indicators and ambient air
      pollution were repeated.
    

Intervention name(s): Wear respirator
Intervention type(s): Behavioral
Intervention description(s): Healthy adult subjects wore the particulate filtering respirators for continuous 48 hours as much as possible both indoor and outdoor.
Other intervention name(s): particulate filtering respirator
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: Heart rate variability; Blood pressure; Circulating biomarkers; Respirator; Fine particulate matter
BPA Levels Relationship With IVF/ICSI Outcomes in Unexplained Infertility
Condition: Infertility Unexplained; IVF; Infertility, Female
MeSH terms: Infertility; Infertility, Female
Study type: Interventional

Summary: 
      The relationship between BPA elevation in urine, blood, and follicle fluid and embryo
      quality, IVF/ICSI outcomes.
    


Intervention name(s): BPA levels
Intervention type(s): Other
Intervention description(s): BPA (Bisfenol A) in urine, blood and follicle fluid samples
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Study of Time-restricted Eating on Weight Loss.
Condition: Obesity; Insulin Resistance
MeSH terms: Insulin Resistance; Weight Loss
Study type: Interventional

Summary: 
      This is a randomized controlled trial studying the effects of time-restricted eating (TRE) on
      weight loss in obese humans. Obesity is the number one risk factor for type 2 Diabetes
      Mellitus (T2DM), and numerous studies demonstrate that weight loss is an effective strategy
      to prevent T2DM and improve the metabolic health of people diagnosed with T2DM.
      Unfortunately, classical calorie restriction diets often fail to produce long-term weight
      loss due to low compliance, reduced resting metabolic rate (RMR), and other factors.
      Therefore, novel dieting techniques must be explored in order to successfully treat obesity
      and prevent T2DM. Studies in mice provide compelling evidence that feeding/fasting cycles can
      be altered to produce beneficial effects on weight loss and metabolic health markers in the
      absence of calorie restriction. Limited research in human subjects suggests that this feeding
      paradigm may translate to human health as well, however, more research needs to be done in
      order to confirm this hypothesis. This study will determine if TRE can lead to weight loss in
      obese human subjects. Secondary outcomes include changes in body composition, HOMA-IR,
      hormonal and biochemical serum markers, RMR, and total energy expenditure (TEE).
    


Intervention name(s): Time-restricted Eating plan; Consistent Meal timing plan
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Research team will prescribe an eating plan for the participant to follow for the 12 week study. The eating plan will consist of eating during a specified 8 hour window and fasting for the remaining 16 hours of the day.; Research team will prescribe an eating plan for the participant to follow for the 12 week study.The eating plan will consist of eating three structured meals each day during three specified meal windows.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: This is a randomized controlled trial. Participants will randomly assigned to one of two diet interventions for the duration of the 12-week study.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Weight loss; Diet; Time-restricted feeding
A Study to Evaluate JNJ-64565111 Pharmacokinetics and Safety in Adult Participants With Varying Degrees of Renal Function
Condition: Kidney Failure, Chronic
MeSH terms: Renal Insufficiency; Kidney Failure, Chronic
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of study is to evaluate the pharmacokinetics of a single, subcutaneous dose of
      JNJ-64565111 in adult participants with varying degrees of renal function including
      participants with end stage renal disease, requiring hemodialysis, compared with participants
      with normal renal function.
    


Intervention name(s): JNJ-64565111
Intervention type(s): Drug
Intervention description(s): All participants will receive a single SC dose of JNJ-64565111 solution on Day 1.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Prepubertal Children With Growth Failure Associated With Primary Insulin-Like Growth Factor-1 (IGF-1) Deficiency
Condition: Growth Disorders; Insulin-Like Growth Factor-1 Deficiency
MeSH terms: Growth Disorders; Failure to Thrive
Study type: Interventional
Phase: Phase 3

Summary: 
      This study is intended to determine whether twice daily weight based dosing with recombinant
      human insulin-like growth factor (rhIGF-1) will safely and effectively increase the growth of
      prepubertal children with short stature associated with low IGF-1 levels but who produce
      sufficient growth hormone (GH). Subjects will be randomized to either an observation arm or
      to active treatment.
    

Detailed description: 
      Prepubertal growth failure associated with primary IGF-1 deficiency (IGFD). Primary IGFD is a
      term that has been used to describe patients with intrinsic cellular defects in GH action. In
      this protocol, primary IGFD is defined as short stature (height standard deviation
      score[SDS]<-2 below the mean for age and gender), low serum IGF-1 (IGF-1 SDS <-2 below the
      mean for age and gender), and levels of growth hormone (GH) that are normal (≥7ng/mL) after a
      GH stimulation test. Primary IGFD is believed to result from a lower than normal ability to
      produce IGF-1 when exposed to normal levels of GH, i.e., a type of GH insensitivity or GH
      resistance.

      This trial is one year, randomized, open label, observation-controlled, parallel-dose
      comparison efficacy and safety study conducted in approximately 40 centers across the United
      States.
    

Intervention name(s): rhIGF-1 (mecasermin, Tercica, Inc.)
Intervention type(s): Drug
Intervention description(s): Twice Daily Injection
Intervention MeSH terms: Mecasermin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Primary IGF-1 Deficiency
Efficacy and Safety Study of Tazarotene (Tazorac) for the Treatment of Brittle Nails
Condition: Brittle Nails
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to determine whether topical tazarotene (Tazorac), a
      receptor-selective synthetic retinoid that normalizes epidermal differentiation, ameliorates
      signs and symptoms of brittle nails.
    

Detailed description: 
      "Brittle nails," referring to nails that chip, peel, or split excessively, occur in up to 30%
      of women and 15% of men, with highest prevalence among the elderly. Treatment of brittle
      nails involves restoration and maintenance of a normal degree of nail plate hydration by
      minimizing exposure to dehydrating chemicals and by use of moisturizers, such as
      alpha-hydroxy acids. Retinoids are vitamin A analogs that play a role in skin cell
      differentiation and proliferation. Tazarotene is a topical receptor-selective synthetic
      retinoid that normalizes epidermal differentiation and reduces the influx of inflammatory
      cells into the skin. In this single-center, open-label trial, subjects applied tazarotene to
      the nails twice daily for 24 weeks. Signs and symptoms were rated by the investigators and
      subjects during treatment and 12 weeks after discontinuation.
    

Intervention name(s): Tazorac
Intervention type(s): Drug
Intervention description(s): All patients were to apply topical tazarotene (Tazorac) twice daily to all affected fingernails for 24 weeks.
Other intervention name(s): Tazarotene
Intervention MeSH terms: Tazarotene
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: brittle nails; Tazarotene; Tazorac
Evaluation of Tiotropium 2.5 and 5 mcg Once Daily Delivered Via the Respimat® Inhaler Compared to Placebo in 1 to 5 Year Old Patients With Persistent Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 2

Summary: 
      The primary objective of this trial is to evaluate the safety and efficacy of two doses of
      tiotropium inhalation solution delivered via the Respimat® inhaler once daily in the
      afternoon in patients (1 to 5 years old) with persistent asthma on top of inhaled
      corticosteroid (ICS) treatment.
    


Intervention name(s): tiotropium-bromide; tiotropium-bromide; placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): IMP; IMP; placebo matching tiotropium
Intervention MeSH terms: Bromides; Tiotropium Bromide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Reactogenicity, Safety and Immunogenicity of QazCovid-in® COVID-19 Vaccine
Condition: Covid19; SARS-CoV Infection; Vaccine Adverse Reaction
MeSH terms: COVID-19; Severe Acute Respiratory Syndrome
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Randomized, blind, placebo-controlled phase- i study and randomized, open phase phase-ii
      study of QAZCOVID-IN®- COVID-19 inactivated vaccine in healthy adult volunteers from 18 years
      old and elder
    

Detailed description: 
      Purpose of the Phase-I clinical study Evaluation of the safety,acceptability and
      immunogenicity of QazCovid-in®-COVID-19 inactivated vaccine when administeredtwice in healthy
      volunteers aged 18-50 years.

      Purpose of the Phase-II clinical study Evaluation of the safety and immunogenicity of
      QazCovid-in® - COVID-19 inactivated vaccine with single and dual use in healthy volunteers
      aged 18 and above.
    

Intervention name(s): QazCovid-in® - COVID-19 inactivated vaccine; Placebo
Intervention type(s): Biological; Other
Intervention description(s): QazCovid-in® (inactivated) Vaccine manufactured by Research Institute for Biological Safety Problems Republic of Kazakhstan; Placebo (sodium chloride bufus, solvent for the preparation of dosage forms for injection 0.9%) The use of placebo: intramuscularly, twice, spaced 21 days apart, at a dose of 0.5 ml (22 volunteers)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: vaccine, I/II phase, safety, immunogenicity, QazCovid-in®
Exploratory Non Comparative Study to Evaluate the Efficacy of Highly Bioavailable Curcumin (Flexofytol) in Patients With Knee Osteoarthritis
Condition: Knee Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The purpose of this study is to evaluate the efficacy of bio-optimized curcumin(Flexofytol)
      during a 90-days period in knee ostearthritis patients on the serum levels of specific
      biomarkers of osteoarthritis and on the evaluation of pain.
    


Intervention name(s): Flexofytol (bio-optimized curcumin)
Intervention type(s): Dietary Supplement
Intervention description(s): 2x3 caps/day (before breakfast and in the evening) for 3 months
Intervention MeSH terms: Curcumin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: osteoarthritis; curcumin; biomarker; pain
Obstetrics and Gynecology Residents and Experts' Knowledge of, Attitudes Toward, Practice Behaviors, and Self-confidence Levels of Caring for Lesbian, Bisexual, and Transgender (LBT+) Patients in Turkey; A Descriptive-cross Sectional Study
Condition: Knowledge, Attitudes, Practice
Study type: Observational

Summary: 
      Obstetrics and Gynecology residents and experts' knowledge of, attitudes toward, practice
      behaviors, and self-confidence levels of caring for lesbian, bisexual, and transgender (LBT+)
      patients in Turkey; A descriptive-cross sectional study
    

Detailed description: 
      There are various studies about LGBT people's problems while utilizing healthcare services
      and interactions with physicians in Turkey and other countries. There is a lack in the
      curriculum for obstetricians and gynecologists regarding LGBT individuals' healthcare
      problems. In this study, we tried to evaluate obstetrics and gynecology residents/experts'
      knowledge level about LGBT individuals, attitudes toward these sexual minority individuals in
      their clinical practices, practice behaviors and experience levels about this condition, and
      their confidence level about caring for sexual minority individuals by performing
      cross-sectional study using online survey platform.
    

Intervention name(s): Obstetrics and Gynecology residents and experts'
Intervention type(s): Behavioral
Intervention description(s): Obstetrics and Gynecology residents and experts' knowledge of, attitudes toward, practice behaviors, and self-confidence levels of caring for lesbian, bisexual, and transgender (LBT+) patients in Turkey (Istanbul)
Observational model: Ecologic or Community
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Turkish Obstetrics and Gynecologists (residents and experts) working active in Istanbul
      
Keywords: LGBT; attitude; knowledge; practice behaviour; self confidence
Mucociliary Clearance Time in Chronic Rhinosinusitis (CRS) Patients After Sinus Surgery
Condition: Chronic Rhinosinusitis
MeSH terms: Sinusitis
Study type: Interventional

Summary: 
      The investigators are looking at the effects of baby shampoo nasal irrigation on the movement
      of mucous in the nose in patients who have undergone sinus surgery for chronic sinus
      problems.
    


Intervention name(s): 1% Johnson's Baby Shampoo
Intervention type(s): Other
Intervention description(s): nasal irrigation 2x a day for 4 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment