Transcranial Direct Current Stimulation Apparatus for Domiciliary Use
Condition: Transcranial Direct Current Stimulation; Healthy Participants
Study type: Interventional

Summary: 
      Neuromodulation is characterized as a technique whose principle neurostimulation to produce
      inhibition or cortical arousal. The tDCS (transcranial direct current stimulation) is a
      noninvasive brain stimulation method used to modulate cortical excitability using low
      intensity direct current (1-2mA) directed to the scalp via cathodes and anodes electrodes;
      the current reaches the cortex, producing hyperpolarization or depolarization of the axonal
      membrane potential. Evidence has shown that this method is presented as a technique that can
      alter cortical and subcortical neural networks. This technique has been used to treat
      psychiatric disorders such as depression, acute mania, bipolar affective disorder panic,
      hallucinations, obsessive compulsive disorder, schizophrenia, withdrawal, rehabilitation
      after-stroke and pain syndromes such as neuropathic pain, migraine, pancreatitis chronic pain
      and fibromyalgia. It is low-cost technique, with virtually no side effects and carries the
      therapeutic effect by neuromodulatory pathways by distinct pathways activated by the drugs.
      In this scenario falls within the importance of developing devices for home use, inexpensive,
      and easy to use so as to maintain the benefits observed in previous studies. The tDCS is
      presented as a non-pharmacological option that may be offered in this context in society. It
      is noteworthy that, if the benefit is demonstrated, the impact will be of great importance to
      patients and to society, since these are focal techniques and low cost. Because they have no
      focal adverse effects of conventional drug treatments. Additionally, can be constituted as
      technical additive to pharmacotherapy in so much pain as in the treatment of other
      neuropsychiatric disorders. Therefore, further studies should be encouraged to increase
      knowledge of their effects and mechanisms involved. If the effectiveness of this method for
      home use is confirmed, the therapeutic impact will undoubtedly be of great importance.
      However, to make this project come true, the investigators depend on support for the
      development and validation of tDCS device for home use, so allowing the qualified knowledge
      can be applied to the clinical setting, as well as advance the development of this area of
      neuroscience in Brazil. Therefore, the aim of this study is to develop tDCS device for home
      use.
    


Intervention name(s): Active tDCS Ambulatory; Sham tDCS Ambulatory; Active tDCS Home use; Sham tDCS Home use
Intervention type(s): Device; Device; Device; Device
Intervention description(s): Procedure begins with the placement of an anode electrode placed on the primary motor cortex (cortex contralateral to the dominant) and the cathode is placed on the contralateral supraorbital region. It is used 1mA direct current transcranial stimulation applied for 20 minutes. Will be held a single session of stimulation. The total time, with initial assessment, tDCS session and final evaluation will be approximately 4 hours.; In sham group, we follow the same procedure and time as the active tDCS ambulatory protocol, but the device will be in the mode sham (inactive). The current is only applied for 30 seconds, so subjects feel a sense of the initial stimulation, but not the remainder receive current. In this group one session will also be held. The total time, with initial assessment, tDCS session and final evaluation will be approximately 4 hours.; The procedure and stimulation time is exactly the same that Active tDCS - ambulatory use, but will use the apparatus for domestic use. Will be explained to the participant as placement of the cap and the device management. This group will be made 11 sessions of tDCS, the first held in the Hospital, with supervision of the researcher. The remaining 10 will be held in the participant's home. The total time of the first meeting, with initial assessment, tDCS session and final evaluation will be around 4 hours. The time of last evaluation is approximately 1 hour.; The procedure and stimulation time is exactly the same that Active tDCS - ambulatory use, but will use the apparatus for domestic use. In sham group, we follow the same procedure and time as the active tDCS protocol, but the device will be in the sham mode (inactive). The total time of the first meeting, with initial assessment, tDCS session and final evaluation will be around 4 hours. The time of last evaluation is approximately 1 hour.
Other intervention name(s): Transcranial Direct Current Stimulation; Transcranial Direct Current Stimulation; Transcranial Direct Current Stimulation; Transcranial Direct Current Stimulation
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Device Feasibility
Keywords: Transcranial direct current stimulation (tDCS); tDCS for domiciliary use; Healthy Participants