Effect of Glutaraldehyde-based Desensitizer in the Control of Tooth Sensitivity and Tooth Color Post- Whitening
Condition: Dentin Sensitivity
MeSH terms: Dentin Sensitivity; Hypersensitivity
Study type: Interventional

Summary: 
      Tooth whitening is one of the most indicated aesthetic procedures in dentistry and there is
      evidence that it interferes with aspects of patients' quality of life. However, the
      sensitivity, associated with the post-procedure period, challenges clinicians and
      researchers. The use of topic desensitizing agents could be a alternative for the control of
      this adverse effects of bleaching agents. The objective of this randomized clinical study,
      therefore, is to evaluate the effect of glutaraldehyde-based desensitizing agent associated
      on tooth sensitivity and tooth color after bleaching with 35% hydrogen peroxide. 25 patients
      will be selected divided into two groups for a double-blind and split-mouth study. Among the
      results it is expected: that the use of glutaraldehyde desensitizing agent helps in the
      control of post-bleaching sensitivity, without harming the final color obtained of patients
      submitted to the proposed clinical protocol.
    

Detailed description: 
      Tooth whitening will be performed in 3 sessions with an interval of 7 days. Desensitizing
      agent and placebo will be applied in all sessions in a split mouth design . All groups will
      receive in-office bleaching treatment according to the steps described below:1 Prophylaxis;
      2- Application of gingival barrier; 3- Application of the desensitizing product or placebo in
      accordance with the established groups; 4- Handling the bleaching material following the
      manufacturer's instructions: applications of whiteness HP35% bleaching gel for 15 minutes
      each, totaling 45 minutes; 5- Final removal of the whitening gel and the gingival barrier
      followed by washing with water.

      Application of the desensitizer or its placebo (step 3) will follow the following sequence:1.
      Relative insulation with cotton rolls; 2- Active application of the product on the buccal
      surfaces of all teeth with the aid of a Microbrush for 10 seconds.; 3- Wait 60 seconds and
      apply a light jet of air until the tooth surface is no longer shiny; 4- Wash with water for
      10 seconds.

      To assess the patient's perception of pain, participants will be provided with a
      questionnaire to be filled out daily for 21 days from the first whitening treatment session.
      The criteria are based on the personal perception of the pain threshold, related to the level
      of sensitivity caused by bleaching treatment. The visual analogue scale (VAS) will be adopted
      as a reference. Numerical scale on which the number 0 (zero) corresponds to total absence of
      pain and 10 (ten) to maximum bearable pain.

      The color records of the bleached teeth will be performed by a single evaluator who will do
      it session :T0- baseline, T1- a week after the first session; T2- a week after the second
      session; T3- a week after the third session. An area of interest for color registration will
      be the middle third of the buccal surface of the teeth, following the the guidelines of the
      American Dental Association. Visual analysis will be performed using a Vita Classical scale
      following a color scale order organized by value. A second color analysis will be performed
      with the aid of a spectrophotometer that acts according to the CIELab and CIEDE 2000 system.
      The region for color evaluation with the Easyshade will be standardized as the middle third
      of the buccal surface of the anterior teeth.
    

Intervention name(s): GLUMA DESINSITIZER; PLACEBO
Intervention type(s): Other; Other
Intervention description(s): GLUTARALDEHYDE; DESTILLED WATER
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: It is a split mouth study composed of two groups randomized between left and right sides.
Masking: Double (Participant, Investigator)
Primary purpose: Supportive Care
Keywords: Tooth Bleaching; dentin adhesives; tooth sensitivity