Comparative Evaluation of the Effectiveness of Diclofenac Sodium Versus Vitamin D on Myofascial Pain
Condition: Myofascial Pain Dysfunction Syndrome,Temporomandibular Joint
MeSH terms: Myofascial Pain Syndromes; Temporomandibular Joint Disorders; Temporomandibular Joint Dysfunction Syndrome; Fibromyalgia
Study type: Interventional
Phase: Phase 4

Summary: 
      It has been reported in the literature that there is a significant relationship between
      bruxism and low serum vitamin D levels. It was aimed to compare the effectiveness of
      diclofenac sodium treatment versus vitamin D supplementation on symptoms in individuals with
      myofascial pain and vitamin D deficiency.
    

Detailed description: 
      In the current literature, it has been reported that there is a significant relationship
      between teeth grinding and low serum vitamin D levels. Vitamin D has been shown to play an
      important role in the musculoskeletal and cardiovascular systems, as well as in the control
      of calcium and phosphate metabolism and in maintaining adequate blood levels of these
      minerals. Vitamin D deficiency has been associated with poor physical performance and low
      muscle strength. There are also studies to understand the relationship between TMJ disorders
      and vitamin D level (serum 25(OH) D). These studies reported a relationship between the
      presence of TMJ disorder and vitamin D deficiency.

      NSAIDs are a large group of drugs that inhibit cyclooxygenases and thus prevent the formation
      of prostaglandins. Traditionally, it has been the most commonly prescribed group of
      medications for pain in the orofacial area. It is recommended to use these drugs regularly
      for at least 2 weeks to achieve an anti-inflammatory effect in individuals with TMJ
      disorders.

      It was aimed to compare the effectiveness of diclofenac sodium treatment versus vitamin D
      supplementation on symptoms in individuals with myofascial pain and vitamin D deficiency.
    

Intervention name(s): Vitamin D; Diclofenac Sodium
Intervention type(s): Dietary Supplement; Drug
Intervention description(s): Study group using Vitamin D for myofascial pain treatment. "Diagnostic Criteria for Temporomandibular Disorders" was used in the diagnosis of patients with myofascial pain. Study group usind Vitamin D for myofascial pain treatment. Medical treatment with Vitamin D (10,000 IU/day) + Occlusal Splint treatment was applied. Occlusal Splints were made of hard acrylic with a flat surface and were used only for 8 hours during sleep for 3 months. 500 mg Paracetamol tablet was prescribed to the patients as a rescue painkiller if they needed painkillers.; "Diagnostic Criteria for Temporomandibular Disorders" was used in the diagnosis of patients with myofascial pain. Control group using Diclofenac Sodium for myofascial pain treatment. Medical treatment with Diclofenac Sodium (Voltaren 75 mg, 2x1 ) + Occlusal Splint treatment was applied. Occlusal Splints were made of hard acrylic with a flat surface and were used only for 8 hours during sleep for 3 months. 500 mg Paracetamol tablet was prescribed to the patients as a rescue painkiller if they needed painkillers.
Other intervention name(s): devit-3; Voltaren
Intervention MeSH terms: Vitamin D; Diclofenac
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: temporomandibular joint; vitamin d; myofascial pain; sodium diclofenac