The Efficacy of Removal of Animal Milk From the Diet in Functional Dyspepsia: A Cross-sectional Study
Condition: Dyspepsia; Gastrointestinal System Disease
MeSH terms: Digestive System Diseases; Gastrointestinal Diseases; Dyspepsia
Study type: Observational

Summary: 
      The goal of this observational study is to learn about compare the effect of removing animal
      milk from diets on the symptoms of FD patients in describe participant population.

      The main question it aims to answer are:

      • Can removing milk and dairy from diets be used to treat FD patients?

      The participants will be divided into two groups and will do the following;

        -  removing milk and dairy products under the advice of a dietician without medical
           treatment

        -  receiving medical treatment without restricted diet.

      Researchers will compare two groups to the effect of removing milk from diet on the symptoms
      of FD patients.
    

Detailed description: 
      In this cross-sectional cohort study, 120 patients with FD diagnosed by the Rome IV criteria
      were included. Patients were divided equally into two groups; those who removed milk and
      dairy products under the advice of a dietician without medical treatment and those who did
      not. For determining the severity of symptoms, "The gastrointestinal Symptom Rating Scale
      (GSRS)" was used at the onset of the study and the end of the one-month follow-up period.

      Between the two groups, there was no statistically significant difference regarding age, body
      mass index (BMI), frequency and duration of symptoms, weight changes in the last six months,
      FD subtypes, and upper GI endoscopy results (p>0.05). Female patients outnumbered men in the
      animal milk removal group (p=0.01). Although the patients in the animal milk removal group
      had higher GSRS scores at the beginning (p=0.01), both groups had similar GSRS scores at the
      end of the study (p=0.99). After one month follow-up period, GSRS scores have improved in
      both groups compared to the baseline (p=0.01). However, the decrease in the GSRS total
      symptom score was significantly higher in the animal milk removal group compared to the free
      diet group (p=0.01). In the evaluation of GSRS symptom subsets, a statistically higher
      reduction was observed in 7 of the 15 subsets in the animal milk removal group compared to
      the free-diet group (p<0.05).

      Of the 120 FD patients who followed up for one month, 60 who removed milk products had a more
      significant reduction in GSRS symptom score and 7 of the 15 symptom subset scores than 60
      patients receiving an unrestricted diet.
    

Intervention name(s): removing milk and dairy products from diets without medical treatment; According to current standard algorithms and guidelines, appropriate treatment for FD types.
Intervention type(s): Other; Other
Intervention description(s): A specialist dietician prepared a diet list based on providing adequate balanced nutrition and is handed over to the diet group without any medical treatment; According to current standard algorithms and guidelines, appropriate treatment for FD types was arranged for the patient group who preferred to receive a free diet
Observational model: Case-Crossover
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients between the ages of 18-65 admitted to the gastroenterology outpatient clinic
        between September 2020 and March 2021, fulfilling the Rome IV Consensus criteria for the
        diagnosis of FD, were included in the study in a cross-sectional and prospective manner
        according to the order of admission
      
Keywords: functional dyspepsia; milk; dairy products