bioihbjkbjnl/mcl2 huggingface dataset:
Evaluation of Galectin-3 Levels in GCF And Saliva of Patients With Different Periodontal Diseases
Condition: Periodontal Diseases
MeSH terms: Periodontal Diseases
Study type: Observational

Summary: 
      The aim of this study is to assess the levels of galectin-3 in the GCF and saliva in patient
      with gingivitis and patient with stage III periodontitis.
    

Detailed description: 
      The aim of this study is to assess the levels of galectin-3 in the GCF and saliva in patient
      with gingivitis and patient with stage III periodontitis.

      This study will be conducted in the Oral Medicine and Periodontology department, Faculty of
      Dentistry- Cairo University, Egypt.

      Patients will be selected from the outpatient clinic of the department of Oral Medicine and
      Periodontology, Faculty of Dentistry-Cairo University.
    

Intervention name(s): GCF obtaining; saliva obtaining
Intervention type(s): Diagnostic Test; Diagnostic Test
Intervention description(s): GCF sample collection by Enzyme-Linked Immunosorbent Assay (ELISA); Saliva sample collection by Enzyme-Linked Immunosorbent Assay (ELISA)
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Dental patients will be recruited in a consecutive manner from the clinic of the department
        of Oral Medicine and Periodontology, Faculty of Dentistry - Cairo University. Medical
        history and dental history will be taken; thorough oral examination will be done. The aim
        of the study will be explained to the patient and the patient's acceptance to participate
        in the survey will be received. Nonrespondent patients or patients refusing to participate
        will be reported with the cause of their refusal. Conventional oral and periodontal
        examination will be held on a dental unit using the light of the unit, mirror and probe
      
Keywords: galectin-3
Effect of Suture for Mesh Fixation in Lichtenstein Hernia Repair
Condition: Inguinal Hernia
MeSH terms: Hernia; Hernia, Inguinal
Study type: Interventional

Summary: 
      The investigators want to evaluate the effect of suturing the mesh versus using a
      self-adhesive mesh for Lichtenstein hernia repair. Effect parameters include chronic pain.
    

Detailed description: 
      Pain is a frequent problem after open inguinal hernia repair. The most frequent operative
      technique for inguinal hernia repair in adults is the Lichtenstein mesh repair, where a
      polypropylene mesh is sutured to the tissue in the inguinal region. We therefore want to
      evaluate the effect of suture for mesh fixation on the occurrence of chronic pain 12 months
      after operation.
    

Intervention name(s): suture; no suture
Intervention type(s): Procedure; Procedure
Intervention description(s): suture for mesh fixation; no suture for mesh fixation, because we use a self-adhesive mesh
Other intervention name(s): Prolene and Vicryl sutures; Progrip mesh
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Keywords: pain
Optimization of Hemodynamic Conditions During Caesarean Section Under Spinal Anaesthesia
Condition: Caesarean Section
Study type: Interventional

Summary: 
      The purpose of this study is to determine wether intravenous Phenylephrine, administered as
      start bolus and following continuous infusion (specific dosage per weight), or optimal lower
      limb bandaging is more effective in preventing hypotension during caesarean section under
      spinal anaesthesia in healthy women.

      The hypothesis is that the Phenylephrine model is superior to lower limb compression in
      preventing hypotension.
    


Intervention name(s): Phenylephrine; Lower limb compression; Placebo
Intervention type(s): Drug; Device; Other
Intervention description(s): Intravenous infusion Dosage 0,25 microgram/kg bodyweight as bolus, continuous infusion with 0,25 microgram/kg/min; Tight bandaging of lower extremity up to hips with compression bandages; Neither phenylephrine nor lower limb bandaging
Intervention MeSH terms: Phenylephrine; Oxymetazoline
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Hypotension; Caesarean section; Spinal anaesthesia; Lower limb compression / wrapping; Phenylephrine
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Condition: Anticoagulants
Study type: Interventional

Summary: 
      Single-institution uncontrolled open-label trial.
    

Detailed description: 
      The single-institution uncontrolled open-label trial is to optimize the anticoagulant therapy
      in the out-patient practice.

      The study embraces patients who are advised to take the anticoagulant therapy for some
      reasons. The study has two phases - a retrospective part and a concurrent part. At the first
      phase, researchers analyze the compliance with the anticoagulant therapy in the real clinical
      practice. At the concurrent phase, researchers conduct a single-institution uncontrolled
      open-label trial to evaluate the effectiveness, safety of the anticoagulant therapy and
      compliance with it at the antithrombotic therapy control ward, and estimate the glomerular
      filtration rate in patients taking the anticoagulant therapy.
    

Intervention name(s): prescribing anticoagulant therapy
Intervention type(s): Other
Intervention description(s): Patients who need anticoagulants were consulted by a cardiologist with subsequent recommendations
Intervention MeSH terms: Anticoagulants
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Rivaroxaban Dabigatran Apixaban
Analgesic Effect of Erector Spinae Plane Block After Caesarean Section
Condition: Ceserean Section and Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      Background: Our hypothesis was that bilateral ESP block applied from the transverse process
      of T9 in women who underwent elective cesarean section with pfannenstiel incision under
      spinal anesthesia could provide effective postoperative analgesia.The primary outcome in this
      study was total opioid consumption for 24 hours.

      Material and Method: This randomized prospective study was carried out on 50 pregnant women
      who was scheduled for elective cesarean delivery via a Pfannenstiel incision with spinal
      anesthesia.Patients were randomly allocated in to two equal groups.Group SA was categorized
      as the group which spinal anaesthesia alone (SA) was performed, Group SA+ESP was categorized
      as group which SA+ESP block was performed. All groups received 7 mg isobaric bupivacaine +15
      µg fentanyl intrathecally through spinal anesthesia. The SA+ESP group, ESP block was
      performed at the ninth thoracic transverse process with 20 ml 0.25% bupivacaine + 2 mg
      dexamethasone immediately after the operation. Total fentanyl consumption in 24 hrs, visual
      analogue scale (VAS) score for pain, time to the first analgesic request were evaluated
      postoperatively.
    


Intervention name(s): Erector Spinae Plane Block
Intervention type(s): Procedure
Intervention description(s): Erector Spinae Plane block is performed by giving local anesthetic to the plan between the erector spinae muscle and the transverse process.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Ceserean section, ESP block, postoperative pain
Adding Insulin to IVF Culture Media Significantly Improve Outcome
Condition: Infertility
MeSH terms: Infertility
Study type: Interventional

Summary: 
      Add insulin to a single step culture media for IVF embryo culture from day 0 to day 5/6 of In
      Vitro culture and detect the the effect upon embryo quality and implantation potential.
    

Detailed description: 
      The IVF culture media design and upgrade underwent many ideas during the last 3 decades, we
      suppose that adding insulin as a hormon and growth factor might improve embryo development in
      vitro so we decide to design a trial to compare the embryogenesis by sibling Oocytes of the
      same patient between to arm of the same culture media and yhe same culture condition but with
      one arm with insulin and the other is traditional one and closely monitor the outcome within
      the 2 arms abd record the results
    

Intervention name(s): Adding insulin to In Vitro culture media
Intervention type(s): Other
Intervention description(s): We will add insulin for in vitro culture of human embryos
Intervention MeSH terms: Insulin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: In Vitro; embryo quality; Intracytoplasmic sperm injection
Drug-drug Interaction Trial Between Rifampicin and BI 409306 in Healthy Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of this trial is to investigate the relative bioavailability of BI
      409306 tablets with prior 7-day intake of rifampicin tablets (Test, T) compared to BI 409306
      tablets without prior administration of rifampicin (Reference, R) following oral
      administration in healthy male subjects.

      The secondary objective is the evaluation and comparison of several pharmacokinetic
      parameters between the treatments. The secondary objectives will be assessed by descriptive
      statistics.
    


Intervention name(s): BI 409306; Rifampicin
Intervention type(s): Drug; Drug
Intervention description(s): Reference and Test Treatment; Test Treatment
Intervention MeSH terms: Rifampin; BI 409306
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Mechanical Posture Changes in Adolescent Female at Public Schools Compared to International Schools
Condition: Adolescent Behavior
Study type: Observational [Patient Registry]

Summary: 
      The aim of this study is to determine different mechanical posture changes in adolescent
      females at public schools compared to international schools.
    

Detailed description: 
      Two hundred adolescent female subjects at public schools and in this study. All subjects will
      be recruited from different schools. 1-Group A: it will be consists of 200 adolescent female
      from public schools, will be evaluated by Posture screen mobile, (BackPEI) questionnaire ,
      VISUAL ANALOG SCALE (VAS)and Depression Anxiety Stress Scales-21(DASS-21).

      2- Group B: it will be consists of 200 adolescent female from international schools, will be
      evaluated by Posture screen mobile, (BackPEI) questionnaire , VISUAL ANALOG SCALE (VAS) and
      Depression Anxiety Stress Scales-21(DASS-21).
    

Intervention name(s): mechanical posture changes
Intervention type(s): Diagnostic Test
Intervention description(s): evaluated by Posture screen mobile, (BackPEI) questionnaire , VISUAL ANALOG SCALE (VAS), Depression Anxiety Stress Scales-21(DASS-21).
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Adolescent female at schools.
Enhancing Spatial Navigation Using Non-Invasive Brain Stimulation
Condition: Mild Cognitive Impairment; Alzheimer's Disease
MeSH terms: Alzheimer Disease; Cognitive Dysfunction
Study type: Interventional

Summary: 
      Remembering how to travel from one location to another is critical in everyday life, yet this
      vital ability declines with normal aging and can be further affected by conditions that
      disproportionately affect the elderly, such as vision loss or progressive dementia. Human and
      animal research has shown that two distinct memory systems interact during navigation. The
      first, referred to as allocentric navigation, is very flexible and uses spatial knowledge of
      key features or landmarks to develop and use a mental map of the environment. This approach
      involves brain regions that are critical for new learning and memory but that decline with
      age. The second, referred to as egocentric navigation, is inflexible and relies on "habit"
      memories that link specific features with specific directions. This approach relies on brain
      regions that are critical for "automatic" responses and that are relatively unaffected by
      age.

      The main problem is that allocentric navigation declines with age and is accompanied
      increased dependence on egocentric navigation. This change increases the risk of becoming
      disoriented or "lost" when traveling in unfamiliar areas or even when traveling new routes in
      familiar areas. Therefore, the main goal of this project is to examine whether non-invasive
      brain stimulation, specifically transcranial direct current stimulation, can improve
      allocentric navigation in healthy older adults and patients with mild cognitive impairment.

      Participants will complete two functional magnetic resonance imaging sessions while learning
      new environments. Before one of these sessions, participants will receive active brain
      stimulation over the parietal cortex. Before the other session, participants will receive
      sham brain stimulation over the parietal cortex. The effects of this stimulation will be
      evaluated using both an allocentric and an egocentric memory test. Physiologic effects will
      be evaluated using both task-based and resting-state MRI.
    


Intervention name(s): Transcranial direct current stimulation (tDCS)
Intervention type(s): Device
Intervention description(s): Active and/or sham; All participants receive both stimulation condition. Groups will be counterbalanced (half receiving active tDCS in the first session and sham in the second session; the other half receiving the opposite).
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Transcranial Direct Current Stimulation
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Aging; Alzheimer's Disease/Dementia; Cognitive Disorders; Imaging; Magnetic Resonance Imaging (MRI); Neurology; Physical Medicine & Rehabilitation; transcranial direct current stimulation
Family-Focused CBT Skills App and Standard Self Help Options for Childhood Anxiety
Condition: Anxiety Disorders; Childhood Mental Disorder; Anxiety
MeSH terms: Anxiety Disorders; Mental Disorders
Study type: Interventional

Summary: 
      Anxiety disorders are among the most common psychological disorders, with prevalent onset in
      childhood and adolescence. While cognitive behavioral therapy (CBT) is considered the
      first-line treatment for pediatric anxiety, significant barriers remain in accessing CBT and
      other evidence-based treatments (EBTs), and credible self-help resources based in EBT
      concepts. This study evaluates a family-guided CBT game application (Anchors App), targeted
      to children ages 6-11 and their families, which focuses on delivering adaptive CBT-based
      coping skills to those who have sub-clinical to mild anxiety and related symptoms in a
      convenient and portable platform. Anchors App will be evaluated in two forms (standard and
      "parent-enhanced") in comparison to use of a self-help book or waitlist control. The rapid
      advancements in technology allows richer interactive capacity, content scalability,
      customizability, and subscription to a broader range of content, which this app capitalizes
      on in order to increase access to CBT skill concepts directly to pediatric stakeholder
      populations. If found to be effective, Anchors App has the opportunity to promote engagement
      of EBT concepts in every-day use through smartphone technology, and will change the landscape
      of mental health prevention and early intervention for children and families.
    


Intervention name(s): Anchors Away; Parent Enhanced Anchors Away; Self-Help E-Book
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Modular Cognitive Behavioral Therapy delivered through a mobile app.; Modular Cognitive Behavioral Therapy delivered through a mobile app. Extra modules will focus specifically on parenting skills relevant to having an anxious child.; Parents will read "Helping Your Anxious Child: A Step-by-Step Guide" (Rapee, Wignall, Spence, Lyneham, & Cobham, 2008)
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: RCT with 4 arms, one being a waitlist arm that allows for re-randomization into one of the 3 "active" study arms.
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: CBT; Self-Help; Family
Use of Laryngeal Mask Airway in Pediatric Adenotonsillectomy
Condition: Laryngeal Mask Airway; Tonsillectomy
Study type: Interventional

Summary: 
      The aim of the current study is to compare the use of laryngeal mask airway (LMA) and
      endotracheal tube (ETT) in pediatric adenotonsillectomy. The primary objective is to assess
      the incidence of post-operative laryngospasm between the LMA and ETT. The investigators also
      sought to compare anesthetic, operative, and recovery times in the LMA and ETT groups. We
      hypothesized that the LMA would be a safe efficient alternative to the ETT.
    


Intervention name(s): Endotracheal Tube; Laryngeal mask airway
Intervention type(s): Device; Device
Intervention description(s): Patients randomized to either Laryngeal Mask Airway or Endotracheal tube prior to undergoing adenotonsillectomy.; Randomized to either Laryngeal mask airway or endotracheal tube
Other intervention name(s): ETT; Endotracheal intubation; LMA
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Comparison of Hematopoietic Stem Cell Activity in Adipose Tissue From Type 2 Diabetic Patients and Healthy Volunteers
Condition: Type2 Diabetes
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      Based on solid preclinical results in mice and preliminary data in humans, this study aims to
      provide the proof of concept of the crucial role of the hematopoietic process occurring in
      human adipose tissue in the initiation of the inflammatory process at the origin of insulin
      resistance and type 2 diabetes (T2D). The main objective is to compare the number of
      pro-inflammatory macrophages derived from human adipose tissue hematopoietic stem cells (HSC)
      according to their origin, type 2 diabetes subjects or healthy volunteers.
    

Detailed description: 
      In mice, increasing data demonstrate a causal relationship between the inflammatory process
      in adipose tissue and the development of insulin resistance, resulting in type 2 diabetes
      occurrence. However, the mechanisms mediating inflammation and its metabolic consequences are
      still unclear. In humans, recent publications have suggested an important interaction between
      the metabolic status and medullar hematopoietic activity. A preliminary study performed by
      the STROMAlab's research team has identified functional hematopoietic stem cells in human
      adipose tissue samples, indicating that adipose tissue-hematopoiesis is an active mechanism.

      To determine whether an alteration in adipose tissue-hematopoiesis could be a hallmark of
      type 2 diabetes in human, biopsies of subcutaneous adipose tissue will be performed in 2
      groups of 10 volunteers: overweight/obese type 2 diabetes subjects versus healthy volunteers,
      matched on age.

      Then, hematopoietic stem cells extracted from human biopsies will be grafted into
      immunodeficient mice and after 12 weeks, flow cytometry using antibodies specific for human
      cell surface markers will be performed to quantify proinflammatory macrophages derived from
      human adipose tissue-hematopoietic stem cells.
    

Intervention name(s): Abdominal subcutaneous biopsies and Blood test
Intervention type(s): Procedure
Intervention description(s): Abdominal subcutaneous biopsies and blood test for each volunteer.
Intervention model: Single Group Assignment
Intervention model description: 20 male volunteers: 10 overweight/obese subjects with T2D and 10 healthy volunteers, age-matched.
All volunteers will be treated in the same way.
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Type 2 diabetes; Adipose tissue; Hematopoiesis; Inflammation; Macrophages
Quetiapine for Mania In Preschool Children 4 to 6 Years of Age With Bipolar Disorder
Condition: Bipolar Disorder; Mania
MeSH terms: Mania; Bipolar Disorder
Study type: Interventional
Phase: Phase 4

Summary: 
      This is an 8-week open-label study aimed at assessing the effectiveness and tolerability of
      Quetiapine, in the treatment of preschool children aged 4 to 6 years with bipolar and bipolar
      spectrum disorder. This is an exploratory, pilot study, seeking to determine whether
      Quetiapine is efficacious and well tolerated in the treatment of preschoolers with pediatric
      bipolar and bipolar spectrum disorder in this age group. The study results will be used to
      generate hypotheses for a larger randomized controlled clinical trial with explicit
      hypotheses and sufficient statistical power.
    

Detailed description: 
      Seroquel is a psychotropic agent that affects multiple neurotransmitter receptors in the
      brain: serotonin 5HT1A and 5HT2, dopamine D1 and D2, histamine H1 (IC50=30nM), and adrenergic
      receptors.

      This is an 8-week open-label study aimed at assessing the effectiveness and tolerability of
      Quetiapine, in the treatment of preschool children aged 4 to 6 years with bipolar and bipolar
      spectrum disorder. This is an exploratory, pilot study, seeking to determine whether
      Quetiapine is efficacious and well tolerated in the treatment of preschoolers with pediatric
      bipolar and bipolar spectrum disorder in this age group. The study results will be used to
      generate hypotheses for a larger randomized controlled clinical trial with explicit
      hypotheses and sufficient statistical power.
    

Intervention name(s): quetiapine
Intervention type(s): Drug
Intervention description(s): 2.5 - 5.0mg/kg PO BID quetiapine
Other intervention name(s): Seroquel
Intervention MeSH terms: Quetiapine Fumarate
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: children; bipolar disorder; quetiapine; preschoolers
The Effect of Prebiotic B-GOS on the Immune Function, Metabolism and Gut Microbiota of Elderly People
Condition: Immunosenescence
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The purpose of this study is to determine the effects of prebiotic B-GOS on the immune
      function, metabolism and gut microbiota of elderly people
    


Intervention name(s): Bi2muno® GOS; Maltodextrin
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 5.5g/day for 10 weeks; 5.5g daily for 10 weeks
Other intervention name(s): galactooligosaccharide; Dextrin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment