Clinical, Functional and Inflammatory Evaluation in Asthmatic Patients After a Simple Short-Term Educational Program
Condition: Asthma; Inflammation; Patient Relations, Nurse; Spirometry
MeSH terms: Inflammation
Study type: Interventional

Summary: 
      Background: Patient education is one of the pillars of asthma treatment according to GINA
      guidelines. It has considered essential for adherence to treatment and for correct technique
      of inhaled devices.
    

Detailed description: 
      Objective: analyze clinical, functional and inflammatory features of adult patients with
      partly controlled and uncontrolled asthma, before and after an educational intervention.
      Methods: 58 adult asthmatic patients (18-70 years old) were randomized into two groups:
      intervention group (IG) (n=38) or control group (CG) (n=26). IG patients were submitted to
      three 30-minutes intervention of a shortterm educational program delivered by a nurse in 3
      visits with a one-month interval. CG group did not receive educational intervention. All
      patients were submitted to a spirometry, induced sputum collection, nitric oxide measure,
      collecting exhaled condensed (cytokine analysis) air and it's ph measure, Asthma Control Test
      (ACT), Asthma Control Questionnaire (ACQ), Asthma Quality Life Questionnaire (AQLQ), Beck
      Depression Inventory (BDI), and answered a symptoms diary, Statistical analysis: repeated
      measures (Sigma Plot Software 3.0).
    

Intervention name(s): Individualized educational program; Induced sputum collection; Spirometry; Nitric oxide measure; Questionnaires ACT, ACQ, AQLQ, BDI; Symptoms Diary; Peak flow measure; Exhaled breath condensate air measurement
Intervention type(s): Behavioral; Diagnostic Test; Diagnostic Test; Diagnostic Test; Other; Other; Diagnostic Test; Diagnostic Test
Intervention description(s): IG patients were submitted to three 30-minutes intervention of a individualized shortterm educational program delivered by a nurse, were given explanations about general aspects of the disease, prevention methods and about the importance and correct use of inhaled corticosteroids, with an educational video showing the use of the device; All participants performed induced sputum collection; All participants performed spirometry test using a Koko spirometer. Pulmonary function was assessed by spirometry prebronchodilator, after withholding short-acting beta-agonists for ≥ 6 hours and long-acting beta-agonist for ≥ 24hours. Forced expiratory volume in one second (FEV1) % predicted was used as a proxy variable for overall lung function.; All participants performed nitric oxide measure in three Mylar bags and measure was performed in a NOA280 Sievers equipment. For collection the patients blew in the balloons through a sterile nozzle in the equipment collector without prejudice or damage to the patient.; All participants answered standardized questionnaires about asthma symptoms and depression: Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), Asthma Quality Life Questionnaire (AQLQ), Beck Depression Inventory (BDI); All participants were instructed to note in the morning and evening before the use of routine inhaled corticosteroids, asthma symptoms (coughing, wheezing, shortness of breath, use of emergency inhaled corticosteroids) and three measures of peak expiratory flow (individual, provided to patients) and to return this completed diary at each study visit; All participants registered three peak flow measures in the symptoms diary by morning and night before the use of routine inhaled corticosteroids. Peak flow was measured by the electronic peak flow meter (Mini-Wright).; Exhaled breath condensate was collect during 15 to 20 minutes in a Turbo DECCS equipment (Medivac SRL, Italy) in a sterile buccal of the own apparatus with the aid of a nasal clip with the participant breathing normally without any effort or damage.
Other intervention name(s): Short term educational program; Induced sputum; Lung function test; NO measure; Peak flow; EBC collection
Intervention MeSH terms: Nitric Oxide
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 64 adult asthmatic patients (18-70 years old) were randomized into two groups: intervention group (IG) (n=38) or control group (CG) (n=26). IG patients were submitted to three 30-minutes intervention of a shortterm educational program delivered by a nurse at 3 mensal intervals. CG group did not receive educational intervention. All patients were submitted to a spirometry, induced sputum collection, nitric oxide measure, collecting exhaled condensed (cytokine analysis) air and it's ph measure, Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), Asthma Quality Life Questionnaire (AQLQ), Beck Depression Inventory (BDI), and answered a symptoms diary, Statistical analysis: repeated measures (Sigma Plot Software 3.0).
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: asthma; inflammation; patients education; spirometry