bioihbjkbjnl/mcl2 huggingface dataset:
Effect of Vitamin D Supplementation on Health of Low Birth Weight Infants
Condition: Vitamin D Deficiency
MeSH terms: Vitamin D Deficiency; Birth Weight
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether a weekly supplement of vitamin D to low
      birth weight term infants will reduce their mortality and hospital admissions and improve
      their immunity.
    

Detailed description: 
      We are conducting a randomised controlled trial of weekly oral vitamin D supplements to low
      birth weight (< 2.5 kg) term infants born in a large government hospital catering to a
      low-middle income population in Delhi. Mothers and infants are recruited at delivery and
      given weekly vitamin D supplements or placebo until 6 months of age. Data on infant
      morbidity, sun exposure and diet, with particular emphasis on breast milk and other milk
      intake, is collected by fieldworkers visiting the homes each fortnight. Mothers are
      encouraged to bring their infants to the hospital in case of any illness and at these visits
      the infant is seen by the project doctor who treats the infant and records additional
      morbidity data. At 6 months blood samples are being collected from a 20% random subsample of
      infants for measurement of 25OHD and indicators of immune activation. The primary outcome is
      mortality or incidence of any illness requiring admission to hospital.
    

Intervention name(s): Vitamin D3
Intervention type(s): Drug
Intervention MeSH terms: Vitamin D; Cholecalciferol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Vitamin D3; morbidity; mortality; low birth weight; supplementation; TH1; TH2; CRP; Neopterin; immune response
Accuracy of Noninvasive Hemoglobin Pulse Oximeter (Rainbow Resposable Adhesive Sensors)
Condition: Healthy
Study type: Interventional

Summary: 
      In this study, the concentration of hemoglobin within the subject's blood will be reduced in
      a controlled manner by administering fluids intravenously. The accuracy of a noninvasive
      hemoglobin sensor(s) will be assessed by comparison to hemoglobin measurements from a
      laboratory analyzer.
    


Intervention name(s): Rainbow Resposable Adhesive Sensors
Intervention type(s): Device
Intervention description(s): Noninvasive Measurement of SpHb
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Mesenchymal Stem Cells in Critical Limb Ischemia
Condition: Critical Limb Ischemia
MeSH terms: Chronic Limb-Threatening Ischemia; Ischemia
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This clinical trial aims to study the safety and efficacy of adult mesenchymal stem cells in
      critical limb ischemia.
    


Intervention name(s): mesenchymal stem cells; Plasmalyte A
Intervention type(s): Drug; Drug
Intervention description(s): Intramuscular injection; Intramuscular injection
Intervention MeSH terms: Plasma-lyte 148
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: mesenchymal stem cells; critical limb ischemia
Effect of Different Food Compositions on Bioavailability of BIIL 284 BS in Healthy Male Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      food effect, relative bioavailability, pharmacokinetics, safety and tolerability
    


Intervention name(s): BIIL 284 BS; high fat meal; low fat meal
Intervention type(s): Drug; Other; Other
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Plaque Psoriasis
Condition: Pruritus; Psoriasis
MeSH terms: Psoriasis; Pruritus
Study type: Interventional
Phase: Phase 2

Summary: 
      Study of the efficacy, safety, and tolerability of serlopitant for the treatment of pruritus
      in adults with plaque psoriasis
    


Intervention name(s): 5 mg Serlopitant Tablets; Matching Placebo Tablets
Intervention type(s): Drug; Drug
Intervention description(s): Serlopitant Tablets; Placebo Tablets
Other intervention name(s): VPD-737
Intervention MeSH terms: Serlopitant
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Allis Clamp Versus Single-tooth Tenaculum
Condition: IUD
Study type: Interventional

Summary: 
      This study aims to determine whether an Allis clamp is an effective clamp for cervical
      stabilization compared to a single-tooth tenaculum.
    


Intervention name(s): Allis clamp; Single-tooth tenaculum
Intervention type(s): Procedure; Procedure
Intervention description(s): Physicians utilized an Allis clam for cervical stabilization during IUD placement.; Physicians utilized a single-tooth tenaculum clam for cervical stabilization during IUD placement.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: Cervical stabilization
Effects of an Online Meditation Course on Quality of Life
Condition: Quality of Life
Study type: Observational

Summary: 
      Many interventions in the field of meditation are becoming increasingly popular and have
      gained worldwide acceptance over the past years, both in terms of health, but also
      psychological aspects. On the other hand, controversial and sometimes hypercritical positions
      are on the rise, questioning the positive effects of meditation on health due to the limited
      availability of high-quality scientific data. With regard to a large number of meditation
      interventions, the systematic exploration of procedures that have not yet been scientifically
      evaluated - also in online settings - is a meaningful contribution to meditation research.
    


Intervention name(s): Meditation
Intervention type(s): Behavioral
Intervention description(s): An online survey will be offered to participants who have enrolled in a 21-day meditation online course. The survey will be conducted using mobile website technology before and after the online course and additionally after 3 and 6 months.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        - All persons registering for the online course
      
Keywords: Meditation
Social Network Based Intervention to Reduce Lead Exposure Among Native American Children
Condition: Lead Poisoning
MeSH terms: Poisoning; Lead Poisoning
Study type: Interventional

Summary: 
      The purpose of this study is to examine whether adding an inter-generational component to an
      existing social network-based lay health advisor intervention increases its effectiveness in
      mobilizing a Native American community to respond to heavy metal contamination from lead and
      zinc mining.
    

Detailed description: 
      Ottawa County, Oklahoma, the site of the research, was heavily mined for zinc and lead in the
      first half of this century. Mine tailings containing heavy metals are stored in large piles
      up to 200 feet in height. Ottawa County is home to 8 Indian tribes and much of the mine waste
      is on tribal land. Specifically, the study will: a) integrate existing Native American youth
      programs with the existing lay health advisor intervention (Society of Clan Mothers and
      Fathers) to form an inter-generational intervention, b) expand the existing lay health
      advisor intervention to address cadmium in addition to lead, c) use participatory research
      methods to involve tribal youth and adults in an air monitoring study, d) assess the extent
      to which the intervention contributes to belief, attitude and behavior changes that will
      reduce heavy metal exposure and absorption in Native American children; and e) assess the
      contribution of the intervention to creating changes in organizational, community, tribal and
      government (city, county, state, federal) capacity to address heavy metal contamination in
      Ottawa County, Oklahoma.
    

Intervention name(s): Education on behaviors to reduce lead exposure
Intervention type(s): Behavioral
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Lead poisoning; Native Americans
Evaluation of Gastrointestinal Motility With SmartPill
Condition: Gastrointestinal Motility
Study type: Observational

Summary: 
      The purpose of this study is to evaluate the clinical usefulness of a capsule (SmartPill~)
      measuring pH, pressure and temperature from within the entire GI tract to determine gastric
      emptying time, combined small and large bowel transit time and total transit time. In
      addition, the Capsule will characterize pressure patterns and provide motility indices for
      the antrum and duodenum. It is believed that the condition of your digestive system can have
      a large impact on your overall physical health. Therefore,the investigators would like to
      assess whether using the pill device helps to determine any functional problems in patients
      in the ICU. The investigators are studying ICU patients because any change in their condition
      can have a large impact on their recovery.
    


Intervention name(s): SmartPill
Intervention type(s): Device
Intervention description(s): Qualifying patients were assigned to the study within four days of hospital admission. They all received a gastro-duodenal tube and capsule. The motility capsule (SmartPill®) was placed into the capsule delivery device (AdvanCE™, US Endoscopy) and advanced blindly into the stomach and released
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        ICU patients with intracranial hemorrhage
      
Keywords: Endoscopy, Video Capsule; Motility, Gastrointestinal
This Study Is To Estimate The Time Course Of Pf-04764793 In The Blood Following Dosing By Oral Inhalation From Dry Powder Inhalers
Condition: Healthy
MeSH terms: Respiratory Aspiration
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to investigate the time course of PF-04764793 concentration in
      the blood following dosing by oral inhalation from dry powder inhalers.
    


Intervention name(s): Treatment A; Treatment B; Treatment C; Treatment D; Treatment E; Treatment F; Treatment G
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): PF-04764793 250/50 using inhaler A; PF-04764793 250/50 using inhaler A; PF-04764793 250/50 using inhaler A; PF-04764793 250/50 using inhaler A; PF-04764793 250/50 using inhaler B; PF-04764793 250/50 using inhaler B; PF-04764793 250/50 using inhaler B
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Electronic Pre-visit Questionnaire to Prompt Discussions of Youth Violence in Primary Care
Condition: Exposure to Violent Event; Bullying
MeSH terms: Bullying
Study type: Interventional

Summary: 
      Pediatricians are supposed to talk about youth violence at all heath supervision visits,
      however these types of conversations rarely occur. There have been no studies assessing tools
      to prompt these discussions. The goal of this study is to see if electronic pre-visit
      questionnaires (PVQs) prompt patient-provider discussion of youth violence (YV) in the
      primary care setting. Additionally, patient-provider characteristics are explored as
      mediators to youth violence discussions, as well as feasibility and acceptability of the PVQ
      by patients and providers.

      Adolescents ages 13 to 21 who come to the Hasbro Primary Care Clinics for annual physicals
      will be recruited. A baseline phase was conducted to look at how often providers ask about
      health-related teen behaviors, assessed by exit survey. The experimental period will involve
      adolescents completing health-related behavior PVQ, given to their doctor prior to the visit.
      Exit survey will assess topics discussed. Experimental group will differ from control group
      based on PVQ containing extra questions about youth violence.
    


Intervention name(s): Pre-Visit Questionnaire
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Health Services Research
Keywords: youth violence; doctor-patient communication; health risk behaviors; pre-visit questionnaires
Combination of Intravitreal Ranibizumab With or Without Micropulse Laser for the Treatment of DME
Condition: Diabetic Macular Edema
MeSH terms: Macular Edema
Study type: Interventional
Phase: Phase 4

Summary: 
      The objective of this study is to evaluate if combination of intravitreal ranibizumab with
      micropulse laser shows non inferiority compared to intravitreal ranibizumab only in diabetic
      macular edema.
    

Detailed description: 
      To investigate the efficacy of intravitreal ranibizumab injections compared to combination
      with Micropulse Laser in Chinese patients with visual impairment in DME.

      The result of the study will be used to support new therapy in DME patients in China.
    

Intervention name(s): Intravitreal Ranibizumab; Micropulse Laser; Intravitreal Ranibizumab as needed
Intervention type(s): Drug; Procedure; Drug
Intervention description(s): All subjections received 3 initial Ranibizumab injections; After 3 initial Ranibizumab injections, Micropulse Laser will be done as needed each month if macular edema persists; After 3 initial Ranibizumab injections, Ranibizumab will be injected as needed till BCVA reaches stabilization
Other intervention name(s): Lucentis; Macular Laser Photocoagulation; Lucentis
Intervention MeSH terms: Ranibizumab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
The Effect of Art Therapy on Pain, Emesis, Anxiety and Quality of Life, Breast Cancer
Condition: Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Interventional

Summary: 
      The research sample consisted of 60 individuals, including the intervention group (n=30) and
      the control group (n=30), who received treatment at the Oncology Center of Sivas Cumhuriyet
      University Practice and Research Hospital. Personal Information Form, Pain Intensity
      Measurement-Visual Analog Scale, Rhodes nausea, vomiting and retching index, Beck Anxiety
      Inventory, FACT-G Quality of Life Scale were applied to the research data. Toxicity Rating
      Scale total score was recorded from the patient file. Within the scope of the research, a
      chemotherapy session for 10 weeks (5 sessions) with an interval of two weeks was made by the
      art expert of the art of marbling, accompanied by a ney concert. No intervention was made in
      the control group. Within the scope of the research, scale forms will be applied to both
      groups in the first interview, in the 3rd and 5th chemotherapy sessions of the patients. The
      data obtained from the study were uploaded to the SPSS (22.0) program and statistical
      evaluation was made.
    


Intervention name(s): Art therapy
Intervention type(s): Other
Intervention description(s): The intervention group is the group in which art therapy is applied. They receive chemotherapy.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: Breast cancer,; art therapy; marbling art; music therapy; pain,; emesis,; anxiety; quality of life
A Study of AK0529 in Chinese Infants Hospitalized With RSV
Condition: Respiratory Syncytial Virus Infections
MeSH terms: Infections; Virus Diseases; Respiratory Syncytial Virus Infections
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a randomized, double-blind, placebo-controlled, multicenter, phase III study to be
      conducted in infants hospitalized with RSV infection in China. The main objectives of this
      study are to investigate the efficacy and safety of AK0529 in Chinese infants.
    


Intervention name(s): AK0529; Matching placebo of AK0529
Intervention type(s): Drug; Drug
Intervention description(s): AK0529 capsule will be orally administered at the twice-daily dosing levels of 10 mg, 20 mg, or 40 mg for five days based on the patient's weight.; The placebo capsule was made with the same smell and appearance as AK0529 but without the active ingredients and will be orally administered per the same treatment schedule as those in the experimental arm.
Other intervention name(s): ziresovir
Intervention MeSH terms: Ziresovir
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Does Double With Regular Monitoring Prevent Undesired Tooth Movement?
Condition: Malocclusion
MeSH terms: Malocclusion
Study type: Observational

Summary: 
      The goal of observational study is to learn about the stability of orthodontic treatment
      results in orthodontic patients during retention phase of treatment.
    

Detailed description: 
      The aim of the present study was to three-dimensionally analyze tooth movement in retention
      phase of treatment and wherever double effectively retention prevents it.
    

Intervention name(s): Intraoral scan
Intervention type(s): Diagnostic Test
Intervention description(s): On the day of debonding, directly following retainer bonding, intraoral scans were performed (T0), using 3Shape Trios 4 (3Shape, Copenhagen, Denmark). The scans were repeated after a month. The patients were invited for repeating the scans after 1 (T1), 3 (T2) and 6 months (T3).
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        The study group comprised 300 patients adult patients (age 18 to 41) who have completed
        fixed orthodontic treatment between (1st January 2021 - 9th September 2022).
      
Keywords: retention; stability; orthodontic treatment; 3D analysis; intraoral scan
Vitamin D in Ectopic Pregnancies
Condition: Ectopic Pregnancy; Vitamin D Deficiency
MeSH terms: Pregnancy, Ectopic; Cardiac Complexes, Premature; Vitamin D Deficiency
Study type: Observational

Summary: 
      According to recent evidences, vitamin D was found to have important roles in female
      reproductive system, both in physiological and also pathological mechanisms. Since vitamin D
      is tightly related with calcium metabolism, both molecules were reported to be associated
      with some pregnancy complications including preeclampsia, gestational diabetes, low birth
      weight, preterm delivery, and cesarean section rates. The aim of the present study was to
      evaluate the vitamin D levels in ectopic pregnancies, which may have clinical importance in
      the etiology of this disorder.
    


Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        ectopic pregnancies and women with normal 1st trimester pregnancies
      
Keywords: Calcium; Magnesium; Inflammation
Adjuvant Gemcitabine Versus 5-FU/Leucovorin Based on hENT1 Immunostaining
Condition: Pancreatic Cancer
MeSH terms: Pancreatic Neoplasms
Study type: Interventional

Summary: 
      Human equilibrative nucleoside transporter 1 (hENT1) is a membrane transporter which is a
      predicting marker for gemcitabine chemotherapy. However, there is a limited evidence of it as
      an indicator for adjuvant gemcitabine chemotherapy. In this study, investigators try to
      investigate the role of hENT1 as a indicator of selection of adjuvant chemotherapy regimen
      between gemcitabine and 5-fluorouracil (5-FU).
    

Detailed description: 
      After surgical resection of pancreatic cancer, the tissue is immunostained by hENT1 antibody.
      The grades of immunostaining are categorized as 0 (0%), 1 (<50%), and 2 (>=50%). According to
      the grade, patients with grade 0 or 1 will be treated with 5-FU and those with grade 2 will
      be treated with gemcitabine. After the study, investigators will calculate the overall
      survival and recurrence free survival of the patients and investigate the role of hENT1 as a
      predictive biomarker for adjuvant gemcitabine chemotherapy.
    

Intervention name(s): hENT1
Intervention type(s): Biological
Intervention description(s): hENT1 is a membrane transporter for gemcitabine. According to the hENT1 staining, patients will be treated with gemcitabine or 5-FU.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Pancreatic cancer; Adjuvant chemotherapy; hENT1; Gemcitabine
Ultrasound Evaluation of Gastric Emptying in Diabetic Patients: a Comparison With Non-diabetic Controls
Condition: Diabetes Mellitus
Study type: Observational

Summary: 
      This is a prospective cohort study. The main objective is to compare the prevalence of a
      "full stomach" using gastric ultrasound technique, in elective surgical patients with
      diabetes mellitus compared to non-diabetic controls following the present fasting guidelines
      (2 h after clear liquid and 6h after a light meal). For patients with a full stomach or
      intermediate stomach, an consecutive ultrasound scan is performed every 10 min,until empty
      stomachstomach contents are detected to determine the mean gastric emptying time for clear
      liquid and light meal, and to investigate the risk factors for delayed stomach emptying in
      diabetic patients by logistic regression analysis .
    


Intervention name(s): Fasting 2 h after clear liquid or 6h after a light meal
Intervention type(s): Other
Intervention description(s): The fasting time for all patients is 2 h after clear liquid or 6h after a light meal, then gastric ultrasound examination is performed.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Study participants will be diabetic and non-diabetic patients who are admitted to the
        surgical department and scheduled to undergo elective surgical procedures. 100 participants
        will be recruited in total.