Effect of Nano-hydroxyapatite and LASER on Dentin Hypersensitivity
Condition: Dentin Sensitivity
MeSH terms: Dentin Sensitivity; Hypersensitivity
Study type: Interventional

Summary: 
      The aim of this study was to evaluate the effect of nanohydroxyapatite associated with low
      potency laser therapy in eliminating or reducing dentin hypersensitivity in a randomized
      placebo-controlled clinical trial. Volunteers 18 to 50 years old with hypersensitive teeth
      were randomized into 4 groups: GPLACEBO - positioning of the laser tip without light emission
      + placebo dentifrice; GnHAP - positioning of the laser tip without light emission +
      nano-hydroxyapatite; GLASER - laser tip positioning with light emission + placebo substance;
      GLASERnHAP - positioning by laser beam with light emission + nano-hydroxyapatite.
    

Detailed description: 
      GLASER received the laser application using the infrared light spectrum with wavelength of
      808 nm with its active AsGaAl medium in two points of the vestibular face of the
      hypersensitive teeth. It was applied at each point 60 J / cm², for 16 seconds. The laser was
      applied in 2 sessions with a time interval of 24 hours. GLASERnHAP first received laser
      application and then the application of nanohydroxyapatite according to the manufacturer's
      recommendations. Before initiating laser therapy, the equipment was calibrated with a tester
      (MMOptics Ltda®, São Carlos, SP, Brazil).

      The GnHAP volunteers were submitted to the application of Desensibilize Nano P on the
      vestibular surfaces of hypersensitive teeth with the aid of a Microbrush applicator
      (Microbrush, 3M ESPE, São Paulo, Brazil) for 10 minutes. Then, a rubber cup (Unid Microdont,
      São Paulo, SP, Brazil) mounted on a low speed handpiece (Dabi Atlante, Ribeirão Preto, SO,
      Brazil) was used to scrub the desensitizing gel on teeth for 20 seconds in each tooth,
      according to the manufacturer's specifications. GPLACEBO followed the same protocol used in
      Gn-HAP. In addition to the desensitization treatment, all GnHAP and GPLACEBO volunteers
      received the positioning of the laser tip to mimic the light emission produced in GLASER and
      GLASERnHAP. The noise emitted by the laser device during mimicry was simulated through the
      sound reproduction of a smartphone application (HD Voice Recorder - iPhone 6s, Apple®,
      Cupertino, California, USA).
    

Intervention name(s): Laser; nano-hydroxyapatite; Laser + nano-hydroxyapatite; PLACEBO
Intervention type(s): Other; Other; Other; Other
Intervention description(s): GLASER received the laser application using the infrared light spectrum with wavelength of 808 nm with its active AsGaAl medium in two points of the vestibular face of the hypersensitive teeth. It was applied at each point 60 J / cm², for 16 seconds. The laser was applied in 2 sessions with a time interval of 24 hours.; The GnHAP volunteers were submitted to the application of Desensibilize Nano P on the vestibular surfaces of hypersensitive teeth with the aid of a Microbrush applicator (Microbrush, 3M ESPE, São Paulo, Brazil) for 10 minutes. Then, a rubber cup (Unid Microdont, São Paulo, SP, Brazil) mounted on a low speed handpiece (Dabi Atlante, Ribeirão Preto, SO, Brazil) was used to scrub the desensitizing gel on teeth for 20 seconds in each tooth, according to the manufacturer's specifications; GLASERnHAP first received laser application and subsequently the application of nanohydroxyapatite according to the manufacturer's recommendations.; In this group, a toothpaste without addition of fluoride or any other desensitizing agent (Natural, Contente®, Uberlândia, MG, Brazil) was applied to hypersensitive dentine. The GPLACEBO volunteers were submitted to the application of placebo dentifrice on the vestibular surfaces of hypersensitive teeth with the aid of a Microbrush applicator (Microbrush, 3M ESPE, São Paulo, Brazil) for 10 minutes. Then, a rubber cup (Unid Microdont, São Paulo, SP, Brazil) mounted on a low speed handpiece (Dabi Atlante, Ribeirão Preto, SO, Brazil) was used to scrub the desensitizing gel on teeth for 20 seconds on each tooth.
Other intervention name(s): Low level laser therapy; dentin desensitization agent based on nano-hydroxyapatite
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Volunteers 18 to 50 years old with hypersensitive teeth were randomly assigned to 4 groups: GPLACEBO - positioning of the laser tip without light emission + placeo substance; GnHAP - positioning of the laser tip without light emission + nano-hydroxyapatite; GLASER - positioning of the laser tip with light emission + plcebo substance; GLASERnHAP - positioning by laser beam with light emission + nano-hydroxyapatite.
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: nano-hydroxyapatite; Laser; desensitizing