bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Mirror Neurons Stimulation on Motor Skill Rehabilitation in Children With Cerebral Palsy
Condition: Children With Spastic Diplegia, Between the Ages of 2 to 10 Years; Gross Motor Function Classification System (GMFCS) Level I,II and III
MeSH terms: Cerebral Palsy
Study type: Interventional

Summary: 
      This study aimed to develop Video Compact Disc (VCD) program that applying the concept of
      imitative learning with mirror neurons stimulation on standard rehabilitation technique in
      children with cerebral palsy. The author will also examine effectiveness of the program by
      compare the motor function measured by the gross motor function measure (GMFM-66) between
      conventional physical therapy and the mirror neurons stimulation based VCD program for six
      months.
    

Detailed description: 
      A randomized controlled trial was performed with thirty children with cerebral palsy
      recruited from Thammasat University Hospital and Rajanukul institute. Informed consent was
      obtained from the participants' parents before participation in this study. The participants
      were randomly assigned according to the randomization list to receive either the mirror
      neurons stimulation based VCD program and practice at home or conventional physical therapy
      for six months. The participants in the experiment group received the mirror neurons
      stimulation based VCD program and practice at home three times a day for six months.
      Concerning the control group, the participants received conventional physical therapy
      regularly at the hospital once a week for first two months and twice a month for last four
      months. Both experimental and control groups were measured their motor functions with gross
      motor function measure (GMFM-66).
    

Intervention name(s): The mirror neurons stimulation based VCD program; The conventional physical therapy
Intervention type(s): Procedure; Procedure
Intervention description(s): The children receive the mirror neurons stimulation based VCD program and practice at home three times a day for six months.; The children were randomly assigned to receive the conventional physical therapy for six months. Both experimental and control groups were measured their motor functions with GMFM-66 by an independent pediatric physical therapist who was blinded for treatment allocation at entry, the second month and the sixth month.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Children with cerebral palsy; Gross Motor Function Measure; Imitative learning; Mirror neuron; Action observation; Conventional physical therapy
Effect of Dry Needling on Surface Electromyographic Activity in Latent Trigger Points
Condition: Trigger Point Pain, Myofascial
MeSH terms: Myofascial Pain Syndromes
Study type: Interventional

Summary: 
      Brief summary: The purpose of this study is to determine the effect of Dry Needling (DN) on
      electromyographic activity in different situations at the latent trigger point (LTrP) point
      of the upper trapezius. Randomized controlled trial, in parallel with the crossover control
      design. Two groups with LTrP in the upper trapezius, and the DN group or the Sham-Dn group
      will be randomly selected.
    


Intervention name(s): Intervention-Dry Needling; Control-Dry Needling
Intervention type(s): Device; Device
Intervention description(s): Deep Dry Needling into the site of the latent TriggerPoint of the upper trapezius muscle. 1 session in upper trapezius muscle moving the needle up and down ten times.; Sham Dry Needling into the site of the latent Trigger Point of the upper trapezius muscle with non-penetrating needles
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Dry needling; Electromyography; Latent trigger point
The Possible Efficacy and Safety of Lansoprazole Co-administration With Neoadjuvant Chemotherapy in Women With Breast Cancer
Condition: Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Interventional
Phase: Phase 3

Summary: 
      Investigation of the possible efficacy and safety of lansoprazole co-administration with
      neoadjuvant chemotherapy in tumor response in women with breast cancer who will be planned
      for surgery.
    

Detailed description: 
      Several studies revealed that PPIs inhibit not only the H+/K+ ATPase in gastric parietal
      cells, but also the vacuolar H+ ATPase (V-ATPase) overexpressed in tumor cells, the V-ATPase
      is an ATP-dependent proton pump that transports H+ across both intracellular and plasma
      membranes to regulate intracellular and extracellular pH.

      Co-administration or pretreatment with PPIs could inhibit H+ transport via the V-ATPase in
      tumor cells, resulting in lower extracellular acidification and intracellular acidic vesicles
      which increase the sensitivity of the tumor cells to the anticancer agents. Moreover, the low
      extracellular pH induces an increased activity of drug efflux pumps P-glycoprotein (P-gp),
      which is closely associated with multi-drug resistance (MDR) of tumors. As a consequence,
      there remains a lower concentration of chemotherapeutic drugs in tumor cells and reduced
      cytotoxic efficacy, thus restoring the normal extracellular PH will decrease MDR.
    

Intervention name(s): Lansoprazole; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): administration of lansoprazole 60 mg twice daily 4 days before starting neoadjuvant chemotherapy regimen and continue till end of chemotherapy cycles; administration of Placebo capsule twice daily 4 days before starting neoadjuvant chemotherapy regimen and continue till end of chemotherapy cycles
Intervention MeSH terms: Lansoprazole; Dexlansoprazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Effects of a High-intensity Progressive-cycle Program on Quality of Life and Motor Symptomatology in Parkinson's Disease
Condition: Parkinson Disease; Exercise; Physical Activity; Quality of Life
MeSH terms: Parkinson Disease
Study type: Interventional

Summary: 
      TITLE: Effects of a high-intensity progressive-cycle program on quality of life and motor
      symptomatology in Parkinson's disease population

      BACKGROUND: The benefits of aerobic exercise in persons with Parkinson's disease (PD) have
      been widely studied; however, little research has been done on the effect of high-intensity
      aerobic exercise in this group.

      HYPOTHESIS: The high-intensity aerobic training in pedaliers, combined with balance training,
      improves motor symptoms and quality of life in a population with Parkinson Disease, Hoehn &
      Yahr 1-3.

      OBJETIVES: To ascertain whether high-intensity aerobic training with exercise peddlers and
      balance training can improve motor symptoms and quality of life in a PD population of Hoehn
      &Yahr (H&Y) disability score 1-3.

      METHODOLOGY Setting: Rehabilitation centers in secondary care. Design: A pilot randomized
      controlled trial. Participants: A total of 14 patients participated in the 8-week study.
      Interventions: They were comprised of a control group (n=7) that followed a balance protocol
      and an experimental group (n=7) that performed high intensity (70%) aerobic workout using an
      exercise peddler + a balance protocol once a week.

      Main Outcome Measures: The primary outcome measures included the 8-Foot Up and Go, test,
      6-minute walk test, test 2-minute step tets, Parkinson Disease Questionnaire-39 (PDQ39),
      Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and Tinetti test.
    


Intervention name(s): Balance; Endurance
Intervention type(s): Other; Other
Intervention description(s): Balance program (10 minutes)
Balance on bosu ball and ball drills Coordination in rings with single leg stance and ball drills Straight line walk with head up Straight line walk and hip flexion, knee flexion and head up
(Duration: 10 minutes. Sets: 2 minutes per exercise. Rest: 30 seconds between exercises); Progressive-cycle program (15-25 minutes)
Warming up Pedalling with 0 resistance (2 minutes)
Main Part* Week 1-2 : 3x2 minutes Week 3-4 : 4x2 minutes Week 5-6 : 5x2 minutes Week 7-8 : 6x2 minutes
Return to resting stage Pedalling with 0 resistance (1 minute)
(*Pedalling with resistance set at 3-4. Rest: 2 minutes between sets or 120 beats/minute. One more set added every two weeks and workout intensity maintained at 70% of heart rate reserve-HRR)
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A pilot randomized controlled trial.
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Neurodegenerative disorders; physical activity; balance; endurance
Distal Radius Fracture Prospective Database 50-80 Years Old
Condition: Radius Fracture Distal
MeSH terms: Fractures, Bone; Radius Fractures; Wrist Fractures
Study type: Observational

Summary: 
      The Problem Distal radius fractures (DRF) are common and result in a variable amount of
      disability. The investigators have completed considerable work in developing tools that
      measure impairment and disability after DRF . The investigators initial studies indicate that
      the associated disablement process is multifactorial and variable with only 25% of the
      resultant disability predicted by baseline patient and injury characteristics. The
      investigators see DRF as a signal event where some people are at-risk of transitioning from
      an active lifestyle to inactivity and subsequent health risks. The investigators recent data
      confirms variable participation following a DRF. The traditional focus in
      orthopedic/rehabilitative approaches to DRF fracture management has been localized to the
      wrist, largely ignoring this potential transition and its health impacts. The investigators
      will initiate a line of investigation that will profile the at-risk older adult who presents
      with a DRF with the ultimate goal of accurate identification and prevention of adverse
      activity transitions (active to inactive). In this study the investigators will identify the
      extent of the problem by quantifying changes in activity/participation and its short-term
      health impacts. The investigators will also identify the risk factors present at time of
      injury that predict a loss of mobility/activity/participation. This work has the potential to
      identify tools and/or clinical prediction rules that identify at-risk individuals at a
      critical time where early intervention might most easily prevent adverse outcomes associated
      with inactivity.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Participants aged 50-80 years of age who have incurred a wrist fracture
      
Keywords: distal radius fracture; Condition; risk factors; adverse activity transitions following DRF; optimal assessment approach
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of PF-06649751 Co-administered With Trimethobenzamide Hydrochloride in Healthy Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will test the hypothesis that PF-06649751 with continuous co-administration of
      trimethobenzamide hydrochloride (TMB) with will be safe and well tolerated. Single doses of
      PF-06649751 will be tested in this study, starting at a low dose and escalating to a dose
      projected to be under the current limits for drug concentration.
    


Intervention name(s): PF-06649751; Trimethobenzamide Hydrochloride
Intervention type(s): Drug; Drug
Intervention description(s): Experimental Pfizer compound.; Trimethobenzamide Hydrochloride is indicated for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.
Other intervention name(s): Tigan
Intervention MeSH terms: Trimethobenzamide
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: Phase 1, Randomized, Double Blind, Placebo-Controlled, Single-Dose Escalation, Safety, Tolerability, Pharmacokinetic, PF-06649751, Trimethobenzamide
Safety and Efficacy Study of Cyclosporine Ophthalmic Emulsion in Post-LASIK Patients
Condition: Dry Eye Syndromes
MeSH terms: Dry Eye Syndromes
Study type: Interventional
Phase: Phase 2

Summary: 
      This study will evaluate the safety and efficacy of cyclosporine ophthalmic emulsion
      administered twice daily following LASIK surgery
    


Intervention name(s): Cyclosporine Ophthalmic Emulsion 0.05% (RESTASIS®); Artificial Tears REFRESH ENDURA®
Intervention type(s): Drug; Drug
Intervention description(s): Cyclosporine Ophthalmic Emulsion 0.05% administered twice daily in each eye for 6 months following LASIK surgery; REFRESH ENDURA® administered twice daily in each eye for 6 months following LASIK surgery
Intervention MeSH terms: Cyclosporine; Lubricant Eye Drops; Cyclosporins
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: LASIK
Polyphenol/Prebiotic Blend Effects on GI Health and Microbial Composition
Condition: GI Health; Microbial Composition
Study type: Interventional

Summary: 
      The gastrointestinal (GI) ecosystem is a complex network of bacterial cells, host cells and
      tissues that change with age. Fewer numbers and less diversity of beneficial bacteria and
      greater number and diversity of non-beneficial bacteria occurs with age and conditions
      associated with accelerated aging (i.e. obesity, high fat diet)(1,2). This imbalance of the
      microbiota contributes to increased inflammation of the gastrointestinal lining and changes
      to the integrity of the intestinal cell wall.

      Prebiotics, such as non-digestible carbohydrates, can induce the growth or activity
      microorganisms that contribute to the well-being of the host. Recent studies have shown that
      prebiotic treatment can have beneficial effects on glucose levels, lipid metabolism, and
      inflammatory markers in an obese population(3). The polyphenol blend is rich in anthocyanins,
      which is a unique subgroup of flavonoids that have been demonstrated to impact the microbiome
      and have anti-inflammatory properties(4,5,6,7). This open-label study will assess the
      benefits of a prebiotic and polyphenol blend in healthy obese adults.
    


Intervention name(s): Polyphenol/prebiotic blend
Intervention type(s): Dietary Supplement
Intervention model: Single Group Assignment
Masking: None (Open Label)
SHR7390 in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer
Condition: Metastatic Castration-resistant Prostate Cancer
MeSH terms: Prostatic Neoplasms
Study type: Interventional
Phase: Phase 2

Summary: 
      This trial aims to prospectively assess the safety and efficiency of SHR7390 in metastatic
      castration-resistant prostate cancer
    


Intervention name(s): SHR7390
Intervention type(s): Drug
Intervention description(s): SHR7390
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Participants With Select Advanced Malignancies
Condition: Select Advanced Malignancies; Kidney Cancer; Clear Cell Renal Cell Carcinoma
MeSH terms: Neoplasms; Carcinoma, Renal Cell; Kidney Neoplasms
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      To evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination with
      Durvalumab versus Nivolumab Monotherapy in Participants with Select Advanced Malignancies.
    

Detailed description: 
      This is a multicenter, open-label, Phase 1/2 study to evaluate the safety, tolerability, PK,
      immunogenicity, and antitumor activity of MEDI0680 in combination with durvalumab or
      nivolumab monotherapy in adult immunotherapy-naïve participants with selected advanced
      malignancies.
    

Intervention name(s): MEDI0680; Durvalumab; Nivolumab
Intervention type(s): Biological; Biological; Biological
Intervention description(s): Participants will receive IV infusion of MEDI0680 0.1 or 0.5 or 2.5 or 10 or 20 mg/kg Q2W in dose-escalation phase and 20 mg/kg Q2W in dose-expansion phase.; Participants will receive IV infusion of durvalumab 3 and 10 mg Q2W in dose-escalation phase and 750 mg Q2W in dose-expansion phase.; Participants will receive IV infusion of nivolumab 240 mg Q2W in dose-expansion phase.
Other intervention name(s): AMP-514
Intervention MeSH terms: Nivolumab; Durvalumab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: select advanced malignancies,; kidney cancer,; clear cell renal cell carcinoma
Lactoferrin Versus Total Dose Infusion (TDI) For Treating Iron Deficiency Anemia in Pregnancy: Role of Nursing
Condition: Iron Deficiency Anemia
MeSH terms: Anemia; Anemia, Iron-Deficiency; Iron Deficiencies; Deficiency Diseases
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This study consisted of 60 cases. All the cases of pregnant women are 4 months to 8 months of
      pregnancy. The cases divided into 30 pregnant women's were given iron supplementation without
      health education and another 30 were given iron supplementation and health education for
      comparison between them. Comparative between hemoglobin levels before and after medication.
      Treatment of iron deficiency anemia with iron supplementation received for one month.
    

Detailed description: 
      The investigator will divide the participants into two groups e.g. group (A) and group (B)
      according to Hemoglobin level and receiving of oral supplementation for IDA accompanied with
      health education in case of group (A) and without health education in case of group (B). Then
      the investigator asked patient to sign the document of her investigations result to receive
      iron supplementation.

        -  After that, the investigator observes hemoglobin's Level, when it less than >11g/dl, the
           patient will be the group (A) who will receive oral iron supplementation and health
           education.

        -  Group (B) who will receive Total Dose Infusion (TDI) without health education.
    

Intervention name(s): Oral lactoferrin; TDI of LMW iron dextran
Intervention type(s): Combination Product; Combination Product
Intervention description(s): Oral lactoferrin 120 mg twice /day and it's based on fast dissolving through direct swallowing per oral route with fruits flavor taste.; Total Dose Infusion of LMW iron dextran up to 20mg/kg body weight is infused intravenously
Other intervention name(s): Oral Fizzing Lactoferrin; Parental dextran
Intervention MeSH terms: Lactoferrin; Dextrans; Iron-Dextran Complex
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Group A will receive oral lactoferrin & group B will receive Total dose infusion
Masking: Single (Participant)
Primary purpose: Treatment
Effects of Virtual Reality Versus Motor Imagery Versus Routine Physical Therapy in Patients With Parkinson's Disease.
Condition: Parkinson Disease
MeSH terms: Parkinson Disease
Study type: Interventional

Summary: 
      The aim of this study is to investigate the effects of VR and MI techniques in addition to
      routine physical therapy on motor skills, balance and ADL in patients with Parkinson's
      disease.
    

Detailed description: 
      Parkinson's disease is one of the most common, insidious neurological disorders with major
      motor symptoms, including bradykinesia, resting tremors, rigidity, and postural disorders.
      Virtual reality and motor imagery are among the more innovative techniques for rehabilitation
      of patients with Parkinson's disease that promote motor learning through both explicit and
      implicit processes.This study is unique in that it examines the effects of VR versus MI on
      motor skills, balance, and daily living activities in individuals with Parkinson's disease
    

Intervention name(s): VR with Routine physical therapy and Virtual reality; Motor Imagery with Routine physical therapy; Routine physical therapy
Intervention type(s): Other; Other; Other
Intervention description(s): VR group will be treated with virtual reality for 15 to 20 minutes along with routine physical therapy for 40 minutes session 3 days/week for 12 weeks; MI group will be treated with virtual reality for 15 to 20 minutes along with routine physical therapy for 40 minutes session 3 days/week for 12 weeks; Group A will be given routine physical therapy in 40-min sessions and 20 min of walking and cycling with a short period of rest, every alternate day (3 days per week) for 12 weeks
Other intervention name(s): Rehabilitation following VR with Routine physical therapy treatment; Rehabilitation following MI with Routine physical therapy treatment; Rehabilitation following Routine physical therapy treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Parkinson; Virtual Reality; Motor Imagery; Routine Physical Therapy
Safety and Efficacy of Honeycomb Microporous Covered Stents (NCVC-CS1) for the Treatment of Intracranial Aneurysms
Condition: Intracranial Aneurysm
MeSH terms: Intracranial Aneurysm; Aneurysm
Study type: Interventional

Summary: 
      This trial is conducted to evaluate the safety and technical effectiveness of using NCVC-CS1,
      a newly developed honeycomb microporous covered stent, for the treatment of intracranial
      aneurysms which are difficult to be cured by conventional surgical or endovascular
      procedures.
    


Intervention name(s): NCVC-CS1
Intervention type(s): Device
Intervention description(s): Intervention Description
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment