bioihbjkbjnl/mcl2 huggingface dataset:
Hepatocellular Carcinoma and Rheumatoid Arthritis
Condition: Carcinoma, Hepatocellular
MeSH terms: Carcinoma; Carcinoma, Hepatocellular
Study type: Observational

Summary: 
      Rheumatoid arthritis(RA) is a disorder with altered immunologic function and increased risk
      of developing malignancies, while studies examining the association between hepatocellular
      carcinoma (HCC) and RA remain lacking. The investigators aimed to investigate the risk of HCC
      between participants with and without RA.
    

Detailed description: 
      The investigators did a retrospective, observational, nested case-control study in a cohort
      that was previously recruited from a population-based RA survey. All participants were
      enrolled prospectively in Taiwan's national health insurance between Jan 1, 1999, and June
      30, 2009, and had follow-up data until Dec 31, 2009. RA was diagnosed based on the 1987
      American College of Rheumatology diagnostic criteria. The investigators matched RA and non-RA
      subjects by propensity score in a 1:1 ratio. The primary outcome was the risk of developing
      HCC. Cox proportional hazards regression was applied to estimate the hazard ratio (HR) and
      95% confidence interval (CI) of HCC for RA and non-RA cohort.
    

Intervention name(s): RA
Intervention type(s): Other
Intervention description(s): RA was diagnosed based on the 1987 American College of Rheumatology diagnostic criteria
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        All individuals were enrolled prospectively in Taiwan's national health insurance between
        Jan 1, 1999, and June 30, 2009, and had follow-up data until Dec 31, 2009
Single Ascending Dose Study of PRX003 in Healthy Subjects
Condition: Psoriasis
MeSH terms: Psoriasis
Study type: Interventional
Phase: Phase 1

Summary: 
      This single ascending dose study is to determine safety, tolerability, pharmacokinetics and
      immunogenicity of PRX003 in approximately 40 healthy subjects.
    


Intervention name(s): PRX003; Placebo
Intervention type(s): Drug; Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Neuromodulation in Depressed and Schizophrenic Patients - Changing MEP (Muscle Evoked Potentials) by tDCS (Transcranial Direct Current Stimulation)
Condition: Schizophrenia; Depression
MeSH terms: Schizophrenia
Study type: Observational

Summary: 
      Muscle evoked potentials (MEP) are supposed to different in schizophrenic and depressed
      patients, compared to a sample of healthy volunteers. Transcranial Magnetic Stimulation
      (TMS)-evoked MEP are measured in all three groups at baseline and after tDCS (2 mA, 20
      minutes). MEP amplitudes are supposed to normalize quickly in healthy volunteers, to stay
      diminished in depressed patients and to stay elevated in schizophrenic patients. These
      differences should disappear after regular pharmacological treatment. Outcome measures will
      be done in week 2 and week 4.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        15 depressed patients 15 schizophrenic patients 15 healthy volunteers
      
Keywords: differences of Muscle evoked potentials (MEP) in psychiatric illnesses; differences in neuromodulation; normalization of neuromodulation after pharmacological treatment
Quickstart of Nexplanon® at Medical Abortion
Condition: Early Pregnancy Termination; Medical Abortion; Postabortion Contraception
Study type: Interventional
Phase: Phase 4

Summary: 
      Women having abortions are at high risk for subsequent unintended pregnancy and repeat
      abortion. Clearly, encouraging contraceptive use after abortion is a high priority. Long
      acting reversible contraceptives (LARCs, Implants and intrauterine contraception) are the
      most effective methods to help women avoid a repeat unwanted pregnancy and abortion. Studies
      in surgical abortion patients, show that "quickstart" of a LARC - i.e., inserting it during
      the surgical procedure - is associated with substantially greater use of that method six
      months later than requiring women to return later to get the device. However, today a
      majority of women chose medical abortion. The clinical routine is to insert LARCs at the
      follow up 2 to 3 weeks after the abortion treatment. Frequently women choose to do part of
      the abortion treatment at home and do not return for a follow up. Thus, the possibility to
      quick start a contraceptive method in medical abortion would be a major advantage especially
      if this could be done at the time of administration of mifepristone.
    


Intervention name(s): Mifepristone; etonorgestrel
Intervention type(s): Drug; Drug
Intervention description(s): Day one of medical abortion
Other intervention name(s): Nexplanon, Contraceptive implant
Intervention MeSH terms: Contraceptive Agents; Mifepristone; Etonogestrel
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: medical abortion; postabortion contraception; LARC; Nexplanon; subdermal contraceptive implant
Effects of Herbal Supplements on Endurance Exercise Performance
Condition: Exercise Performance
Study type: Interventional

Summary: 
      Cordyceps and Rhodiola are two common herbal supplements marketed and consumed as adaptogens
      to athletes with regard to enhanced performance. The effects of these supplements has been
      well studied in animals but whether or not the same effects translate to humans is still
      unclear. Thus, the primary purpose of this study is to determine whether combined
      supplementation of Rhodiola and Cordyceps, compared to Rhodiola alone and placebo, will
      demonstrate a greater improvement in oxygen consumption (ie. VO2 max).
    

Detailed description: 
      Herbal supplements are consumed worldwide with surveys approximating five billion dollars
      spent annually by consumers in the United States alone. Herbal supplements, such as Rhodiola
      and Cordyceps, both of which are considered to be adaptogens, remain popular among athletes.
      These adaptogens act as antioxidants, which have been speculated to confer endurance
      performance benefits by delaying muscle fatigue via the attenuation of muscle damage
      accumulation and its related by-products during prolonged or exhaustive exercise.
      Nevertheless, previous research investigating the individual effects of Rhodiola and
      Cordyceps on aerobic training performance remain equivocal. Moreover, literature elucidating
      the potential additive effects of Rhodiola and Cordyceps in human subjects are scarce.
      Therefore, the purpose of the present study is to determine the acute, additive influence of
      oral Rhodiola and Cordyceps supplementation on VO2 max, with secondary variables of interest
      being plasma glucose and lactate concentration, and measures of gastrointestinal distress.
    

Intervention name(s): Placebo of calcium; Rhodiola; Rhodiola and Cordyceps
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Ingestion of 250 mg of calcium; Ingestion of 250 mg of Rhodiola; Ingestion of 250 mg of Rhodiola and 225 mg of Cordyceps
Intervention MeSH terms: Calcium
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Blocked-randomized, crossover design
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Epidemiological Study About the Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis
Condition: Candidiasis, Vulvovaginal
MeSH terms: Candidiasis; Candidiasis, Vulvovaginal
Study type: Interventional
Phase: Phase 4

Summary: 
      To determine proportion of women achieving clinical and mycological cure or have recurrences
      / reinfection after being treated for an acute episode of vulvovaginal candidiasis.
    


Intervention name(s): Clotrimazole
Intervention type(s): Other
Intervention description(s): All patients receive standard antifungal treatment for this type of infections consisting Clotrimazole 500 Single dose (standard treatment).
Intervention MeSH terms: Clotrimazole; Miconazole
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Candidiasis
Efficacy and Tolerance Evaluation of a "Revitalizing" Face Treatment
Condition: Face Aging/Photo Aging of Moderate Grade
Study type: Interventional

Summary: 
      Efficacy and Tolerance Evaluation of a"revitalizing" face treatment consisting of a day and a
      night cream
    

Detailed description: 
      Aim of the study was to evaluate clinically and by non-invasive instrumental evaluations the
      activity of a "revitalizing" face treatment consisting of a day and a night cream, applied
      for an uninterrupted period of 3 months, by female volunteers, aged 35-60 years, with
      aging/photo aging of moderate grade.
    

Intervention name(s): Nutriage SPF 30 day cream and Nutriage night cream (Difa Cooper S.p.a, Italy)
Intervention type(s): Other
Intervention description(s): A fixed quantity of both cosmetic products was applied for an uninterrupted period of 3 months, on the face included the submental area (day cream at the morning and the night cream at the evening), preferentially always at the same hour, with a mild massage
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Transverse vs Longitudinal Incision in Myomectomy
Condition: Myoma;Uterus
MeSH terms: Leiomyoma; Myofibroma
Study type: Interventional

Summary: 
      The Aim of the study is to compare between transverse and longitudinal uterine incision in
      abdominal myomectomy regarding intraoperative blood loss.
    


Intervention name(s): Longitudinal uterine incision; Transverse uterine incision
Intervention type(s): Procedure; Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Improving Oral Health With Serious Games
Condition: Caries; Tooth Decay; Cavities; Gingivitis
MeSH terms: Gingivitis
Study type: Interventional

Summary: 
      This study investigated if computer games can be effective at changing the way children take
      care of their teeth. We a museum exhibit with 3D virtual reality games called "Attack of the
      S. Mutans!" Our hypothesis was that children who played the games and visited the exhibit
      would show improved attitudes about oral health, which would translate into improved brushing
      and self-care habits.

      In this randomized controlled study with school children aged 8-12, we compared the outcomes
      for three groups: Group 1) Visited Attack of the S. Mutans!; Group 2) Experienced a hands-on
      classroom presentation about virtual reality being used for healthcare; Group 3) Received
      no-treatment.
    


Intervention name(s): Attack of the S. Mutans; Follow-up; SnowWorld
Intervention type(s): Other; Other; Other
Intervention description(s): A research assistant led groups of students through the Attack of the S. Mutans exhibit. All participants played all the games and viewed all the graphical content of the exhibit.; This group experienced the Attack of the S. Mutans! exhibit and 3 doses of follow-up booster content at a web site.; SnowWorld is a 3D first-person-shooter game developed by Firsthand Technology. In SnowWorld, the player shoots snowballs at penguins, polar bears, and other features of a frozen landscape. The game is designed to help burn victims cope with pain, and has no oral health messages.
Other intervention name(s): AOTSM
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: video games; oral health; social cognitive theory; behavior change; randomized trial; growth modeling; minority; gender
Intra-Nasal Mechanical Stimulation (INMEST) as a Treatment of Keratoconjunctivitis Sicca (Dry Eye Syndrome)
Condition: Keratoconjunctivitis Sicca (KCS)
MeSH terms: Dry Eye Syndromes; Keratoconjunctivitis; Keratoconjunctivitis Sicca
Study type: Interventional

Summary: 
      The purpose of the study is to evaluate how treatment with Intra-Nasal Mechanical Stimulation
      (INMEST) in the nasal cavity in patients with Keratoconjunctivitis sicca can relieve these
      symtoms.
    


Intervention name(s): KCS Medical Device; KCS Medical Device
Intervention type(s): Device; Device
Intervention description(s): Patient treated 6 times with the Active KCS Medical Device during 2 weeks.; Patient treated 6 times with the Inactive KCS Medical Device during 2 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Double blinded randomised clinical trial
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
A Study in Healthy Adult Volunteers to Assess the Safety and Pharmacokinetics of an Investigational Imaging Product
Condition: Healthy Subjects
Study type: Interventional
Phase: Phase 1

Summary: 
      The objective of this study is to assess the safety and tolerability of ASP5354 administered
      intravenously as a single dose to healthy subjects. This study will also assess the single
      dose pharmacokinetics of ASP5354 in plasma and urine.
    

Detailed description: 
      This is a study comprising of 5 cohorts (cohorts 1 to 5) of 6 healthy subjects in each cohort
      (4 in each ASP5354 cohort and 2 in each placebo cohort). If the data from cohorts 1 to 3 are
      sufficient to characterize safety, tolerability and pharmacokinetics and the assessed doses
      reach the expected urine ASP5354 concentration, the study may be ended without running the
      fourth or fifth cohorts.
    

Intervention name(s): ASP5354; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Intravenous; Intravenous
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Tolerability; Pharmacokinetics; Safety; ASP5354
Prospective, Randomized, Controlled, Clinical Study on Tolerability and Efficacy of hMG-IBSA
Condition: Infertility
MeSH terms: Infertility
Study type: Interventional
Phase: Phase 3

Summary: 
      Purpose of the study is the evaluation of the tolerability (both local and systemic) and the
      clinical efficacy (in terms oocytes recovered) of subcutaneously versus intramuscularly
      administered Merional® (IBSA, Lugano - CH) in patients undergoing controlled ovarian
      hyperstimulation (COH) in an ART programme (IVF).
    


Intervention name(s): hMG-IBSA; Ovarian stimulation
Intervention type(s): Drug; Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Intervention Study on Break Activities and Workers´ Psychological and Physiological Health & Performance
Condition: Exposure to Nature During Lunch Breaks; Relaxation Exercises During Lunch Breaks
Study type: Interventional

Summary: 
      The objective of this research project is to understand and to improve workers´ recovery from
      work stress. Although recovery during lunch breaks is the most common within-workday break,
      it has received only minor research attention. Therefore, we will study whether lunch breaks
      including a relaxation session or exposure to nature have more favorable outcomes than
      usually spent lunch breaks concerning: a) recovery processes, b) health, c) well-being, d)
      job performance and e) creativity. We approach recovery by combining the theoretical
      frameworks of work and environmental psychology.
    

Detailed description: 
      We conduct an intervention study in a sample of 200 knowledge-workers who engage in different
      lunch break activities for 15-minutes per day, two weeks in a row. We randomly assign
      participants to three experimental conditions: 1) exposure to nature, 2) relaxation and 3)
      control group (lunch break spent as usual). Online questionnaires before and after the
      intervention assess long term changes regarding recovery processes and the major outcome
      variables. Before, during and after the intervention, SMS and paper-pencil questionnaires
      measure the same constructs four times a day with fewer items. We also measure blood pressure
      and collect saliva samples to map cortisol excretion across the intervention period. A timed
      experimental task (i.e., the Alternative Uses Task) is used to examine differences in
      creativity between the three groups after the intervention period.

      By combining the knowledge of work and environmental psychology about recovery and
      restorative experiences, by merging three recovery perspectives (settings, processes, and
      outcomes) and by using data triangulation, we produce valid results that broaden our view on
      mechanisms underlying recovery and enhance our understanding about their links to
      psychological, behavioural and physiological outcomes, resulting in a more comprehensive
      picture of work stress recovery in general.
    

Intervention name(s): Park walk during lunch break; Relaxation during lunch break
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: lunch breaks, recovery, nature, park walking, relaxation
Cannabidiol Treatment of Cognitive Dysfunction in Schizophrenia
Condition: Schizophrenia; Schizoaffective Disorder
MeSH terms: Schizophrenia; Cognitive Dysfunction; Psychotic Disorders
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is a six-week, randomized, placebo-controlled, fixed dose trial comparing
      cannabidiol Vs. placebo added to a stable dose of antipsychotic medications in patients
      diagnosed with schizophrenia.
    


Intervention name(s): Cannabidiol; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Active Cannabidiol daily over 6 weeks; Placebo
Intervention MeSH terms: Cannabidiol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Study To Estimate The Effect Of Ketoconazole On The Pharmacokinetics Of Pf-04937319 In Healthy Subjects
Condition: Human Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will evaluate the potential for a drug-drug interaction of PF-04937319 with
      ketoconazole, a potent inhibitor of the drug metabolizing enzyme CYP3A.
    


Intervention name(s): PF-04937319 / ketoconazole
Intervention type(s): Drug
Intervention description(s): Single 20 mg dose of PF-04937319 on day 1, multiple dose of ketoconazole 200 mg twice daily from day 3 to 7, single 20 mg dose of PF-04937319 on day 6
Intervention MeSH terms: Ketoconazole
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Drug Interaction; pharmacokinetics; ketoconazole; CYP3A
Impacts of Application of Virtual Reality on Gait and Balance for Stroke Patients
Condition: Stroke
MeSH terms: Stroke
Study type: Interventional

Summary: 
      The goal of this clinical trial is to learn about effects of virtual reality combined with
      conventional therapy on the balance, gait, and quality of life in stroke patients in the
      subacute and chronic stages. The main questions it aims to answer are:

      • Virtual reality combined conventional therapy interventions can improve the gait, balance
      and functional status of stroke patients or not?

      Participants will asked to do about 3 tasks in virtual reality intervention

        -  Walk in the flat ground

        -  Cross the obstacle on the ground

        -  Cross to moving obstacles
    

Detailed description: 
      The investigators referred to the scenes designed by previous studies to develop the three
      virtual environments employed in this study and made slight modifications according to
      Taiwan's conditions. Google Earth Virtual Reality (Google Inc., Mountain View, California,
      U.S., 2017) was uesd for the first and second task and Street Champ Virtual Reality (Zynk
      Software Srl , Cluj, Romania, 2016) was used for the third task.

      Time constraints, terrain changes, and moving obstacles were set to increase the difficulty
      of the walking task. The speed obtained by the 10-m walking pretest was used as the training
      benchmark. The participants had to complete a task three times to proceed to the next level.

      For Patient Registries: on-site audit.The subjects were referred from the rehabilitation
      Clinic of Kaohsiung Municipal Ta-Tung Hospital
    

Intervention name(s): Virtual reality training
Intervention type(s): Other
Intervention description(s): Virtual reality Training for 12 sessions, two to three times for one week, one training session last for 20 minutes
Intervention model: Single Group Assignment
Intervention model description: The subjects that received virtual reality functional gait training for 12 sessions. During the virtual reality intervention, they also received routine conventional rehabilitation therapy for twice a week, and training lasted for one hour. The 6-minute walking test (6MWT), 10-meter walk test (10MWT), Berg balance scale (BBS) and Chinese version of the Activities specific Balance Confidence scale were assessed pre- and post-intervention.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: stroke; balance; virtual reality; walking pace; gait