bioihbjkbjnl/mcl2 huggingface dataset:
IgA Nephropathy, Lymphocyte Homing and IgA Class Switch
Condition: IgA Nephropathy
MeSH terms: Kidney Diseases; Glomerulonephritis, IGA
Study type: Interventional

Summary: 
      IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world and it
      represents an important cause of end-stage kidney failure. This disease was described as a
      distinct entity in 1968 by J Berger and N Hinglais. The aetiology and the pathogenesis remain
      still obscure. Clinical observations and immunisation studies indicate that IgAN represents a
      dysregulation of the immune system, rather than an intrinsic renal abnormality. Twenty years
      ago, some authors proposed the mucosa-bone marrow axis to explain the pathogenesis of the
      disease. Mucosal IgA plasmocytes are displaced and take up residence in systemic sites. The
      unusual characteristics featured by the IgA produced by these cells (charge, size,
      glycosylation) drive their accumulation, deposition and mesangial activation characteristic
      of IgAN.

      Evidence is emerging that altered lymphocyte homing may ultimately explain this aberrant
      localization.
    


Intervention name(s): blood test
Intervention type(s): Other
Intervention model: Single Group Assignment
Masking: None (Open Label)
Virtual Reality Walking for Neuropathic Pain in Spinal Cord Injury
Condition: Spinal Cord Injuries; Neuropathic Pain
MeSH terms: Spinal Cord Injuries; Neuralgia; Wounds and Injuries
Study type: Interventional

Summary: 
      This study will examine the effectiveness of one of two virtual reality treatments on
      neuropathic pain in individuals with spinal cord injury.
    

Detailed description: 
      The investigators are investigating the effectiveness of one of two possible investigational
      virtual reality treatments on neuropathic pain in individuals with spinal cord injury.
      Participants will be randomized to one of these two treatments.
    

Intervention name(s): Non-Interactive Virtual Reality Walking; Interactive Virtual Reality Walking
Intervention type(s): Other; Other
Intervention description(s): Individuals will wear a head-mounted display to allow them to visualize virtual legs in the virtual environment. When wearing the display, individuals will see the legs and arms of their virtual avatar from a first-person perspective.
Individuals will engage in virtual reality sessions in their home twice daily over the course of 10 days in a two-week period. Each daily session will take approximately 30 minutes, with 5-10 minutes dedicated to the virtual walking experience. Additionally, each daily session will be scheduled a minimum of 4 hours apart.; Individuals will wear a head-mounted display to allow them to visualize virtual legs in the virtual environment. When wearing the display, individuals will see the legs and arms of their virtual avatar from a first-person perspective.
Individuals will engage in virtual reality sessions in their home twice daily over the course of 10 days in a two-week period. Each daily session will take approximately 30 minutes, with 5-10 minutes dedicated to the virtual walking experience. Additionally, each daily session will be scheduled a minimum of 4 hours apart.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants will be randomly assigned to one of two intervention arms. Both groups receive the same number of sessions, duration of sessions, and measures procured.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Virtual Reality
Human Papillomavirus and Rate of Pregnancy Achieved Via Medically Assisted Procreation
Condition: Infertility; Sub-fertility; Papillomavirus Infections
MeSH terms: Infections; Papillomavirus Infections; Infertility
Study type: Observational

Summary: 
      The main objective of this study is to investigate the association between the presence of
      HPV infection in one or both members of infertile/sub-infertile couples and the outcome of
      pregnancies obtained by assisted reproduction.

      The success of assisted medical procreation is defined as achieving a pregnancy resulting in
      the birth of a living, viable child.
    

Detailed description: 
      The secondary objectives of this study are:

      A. To study the alterations of sperm present in infertile men according to the presence of
      HPV in semen.

      B. Identify the specific HPV genotypes involved.

      C. To study a potential link between HPV and embryonic characteristics (as classified by
      Giorgetti)

      D. To study a potential link between HPV and survival of the conceptus: products of
      miscarriage or stillbirth, duration of pregnancy, birth weight.

      E. To study a potential link between HPV and fetal malformations.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The study population consists of couples under care for infertility in the participating
        centers. Gamete donations are not included.
      
Biospecimen description: 
      Samples collected (semen and cervical smears) will be sent to the Virology Laboratory of the
      Hôpital St-Eloi, CHU Montpellier, for analysis. After analysis, the remains of viral DNA will
      be banked for future studies on the Papilloma Virus.
    
Keywords: Medically assisted procreation; Assisted reproductive technology; Human papilloma virus
Long-Term Effects of Aortic Valve Mismatch
Condition: THE LEFT VENTRICULAR REMODELING AFTER MECHANICAL AORTIC VALVE REPLACEMENT
MeSH terms: Ventricular Remodeling
Study type: Interventional

Summary: 
      The real impact of the existence of an aortic valve mismatch after aortic valve replacement
      in various studies conducted so far is a source of controversy. There is currently no
      long-term impact of the aortic valve mismatch on the reversal of left ventricular remodeling
      and its impact functional.To evaluate these effects of aortic valve mismatch on abilities to
      the effort, the quality of life and the regression of left ventricular hypertrophy long term
      after a aortic valve replacement, conducting a new study is fundamental. This study is even
      more essential in patients with a young life expectancy theoretical long and physical
      activity.Our study aims to determine whether the existence of an aortic valve mismatch has an
      influence on: The functional capacity to the effort by measuring the maximum oxygen
      consumption during a stress test (VO2 max) The reversal of left ventricular remodeling
      (cardiac ultrasound doppler), diastolic dysfunction (cardiac ultrasound and Doppler
      measurement Brain Natriuretic Peptide (BNP). This study will analyse these data in patients
      who received youth a VAN by mechanical aortic valve prosthesis.
    


Intervention name(s): exercise training; subjects are asked to exercise during 20 or 30 minutes
Intervention type(s): Other; Other
Intervention description(s): subjects are asked to exercise 20 or 30 minutes.; subjects are asked to exercise during 20 or 30 minutes
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Keywords: THE LEFT VENTRICULAR REMODELING AFTER MECHANICAL AORTIC VALVE REPLACEMENT; exercise training
Comparison of McGrath and Macintosh Laryngoscope for DLT Intubation
Condition: Intubation; Difficult; Thoracic Diseases; Intubation Complication
MeSH terms: Thoracic Diseases
Study type: Interventional
Phase: Phase 4

Summary: 
      The investigators previous study showed that McGrath Series 5 videolaryngoscope is an
      alternative tool for double-lumen tube intubation. But it is not determined about the
      advantages and disadvantages of McGrath Series 5 videolaryngoscope for double-lumen tube
      intubation, compared with traditional Macintosh laryngoscope.
    

Detailed description: 
      The investigators designed a randomised controlled study to compare of McGrath Series 5
      videolaryngoscope and Macintosh laryngoscope for DLT intubation.
    

Intervention name(s): videolaryngoscope; Direct laryngoscope
Intervention type(s): Device; Device
Intervention description(s): a kind of videolaryngoscopes, which are widely used in difficult airways.; A kind of traditional laryngoscopes
Other intervention name(s): McGrath series 5 videolaryngoscope; Macintosh laryngoscopes
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: videolaryngoscope; double lumen intubation
A Safety and Efficacy Study of VI-0521 to Evaluate the Long Term Treatment of Obesity in Adults With Obesity-Related Co-Morbid Conditions. An Extension Study of Protocol OB-303 (NCT00553787)
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to evaluate the long-term safety and efficacy of VI-0521
      compared to placebo for the treatment of overweight and obesity in adults who have completed
      study OB-303 (NCT00553787) at selected study sites. This is an extension study of protocol
      OB-303 (NCT00553787).
    


Intervention name(s): VI-0521; Placebo; VI-0521
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 7.5 mg phentermine and 46 mg topiramate; placebo; 15 mg phentermine and 92 mg topiramate
Other intervention name(s): Qsymia; Qnexa; PHEN/TPM; Qsymia; Qnexa; PHEN/TPM
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Obesity
Retinal Function in Diabetic Patients Without Retinopathy
Condition: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2
MeSH terms: Retinal Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 1
Study type: Observational

Summary: 
      The primary purpose was to assess, in diabetic patients without diabetic retinopathy and
      control subjects, color vision, contrast sensitivity, electroretinography, and
      flicker-induced vasodilatation using the Dynamic Vessel Analyzer, in order to specify the
      earliest impaired retinal cells in diabetes, and gain more insight into diabetic retinopathy
      pathogenesis.
    

Detailed description: 
      Type 1 and type 2 diabetic patients with no diabetic retinopathy and no hypertension were
      compared with sex and age-matched control subjects. Color vision was tested with the
      desaturated LANTHONY 15-Hue test. Contrast sensitivity was assessed with the Pelli-Robson
      contrast sensitivity test. Pattern-electroretinogram, Ganzfeld full-field electroretinogram
      and multifocal electroretinogram were recorded according to the International Society for
      Clinical Electrophysiology of Vision (ISCEV). Flicker-induced vasodilatation in retinal
      arteries and veins was assessed using the Dynamic Vessel Analyzer.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        For diabetic patients :

        age between 20 and 55 type 1 or type 2 diabetes mellitus diabetes duration of more than 5
        years no diabetic retinopathy on fundus examination or fundus photographs

        For control subjects :

        sex and age matching with the diabetic patients no diabetes, no familial or personal
        history of elevated blood sugar
      
Keywords: Diabetic retinopathy; Color vision; Contrast sensitivity; Electroretinogram; Flicker-induced vasodilatation; Dynamic Vessel Analyzer
A Study of Trimetrexate Plus Leucovorin in Children With Pneumocystis Carinii Pneumonia
Condition: Pneumonia, Pneumocystis Carinii; HIV Infections
MeSH terms: Pneumonia; Pneumonia, Pneumocystis
Study type: Interventional

Summary: 
      To evaluate the safety and efficacy of trimetrexate glucuronate with leucovorin protection in
      pediatric patients with Pneumocystis carinii pneumonia (PCP) who are refractory to or have
      demonstrated severe or life-threatening toxicities to standard therapies (e.g., TMP/SMX or
      parenteral pentamidine).
    

Detailed description: 
      Patients receive intravenous infusions of trimetrexate glucuronate and leucovorin for 21
      days. Leucovorin is continued for 3 additional days after discontinuation of trimetrexate
      glucuronate. Patients are followed for 1 month.
    

Intervention name(s): Trimetrexate glucuronate; Leucovorin calcium
Intervention type(s): Drug; Drug
Intervention MeSH terms: Leucovorin; Trimetrexate; Calcium; Levoleucovorin
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Trimetrexate; Pneumonia, Pneumocystis carinii; Leucovorin; Drug Therapy, Combination; Acquired Immunodeficiency Syndrome
The Influence of Deep TMS on Cerebellar Signs in Patients With Machado Joseph Disease
Condition: Machado Joseph Disease (SCA3)
MeSH terms: Machado-Joseph Disease
Study type: Interventional
Phase: Phase 2

Summary: 
      To test the effects of low frequency deep rTMS using the novel HCERMJD-coil on cerebellar
      deficits in patients with SCA3 and to establish its safety in this population.

      Investigator is anticipate that stimulation of the cerebellum with the novel HCERMJD-coil may
      induce significantly therapeutic effects in patients with SCA3 and will pave the way for
      establishing a novel and effective treatment for this disorder.
    


Intervention name(s): Deep TMS
Intervention type(s): Device
Intervention description(s): 1Hz Stimulation
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Machado Joseph disease; Deep TMS; TMS; Transcranial Magnetic Stimulation; SCA3; Magnetic Stimulation; Brainsway
A Study of LY2409021 in Patients With Type 2 Diabetes
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 2

Summary: 
      LY2409021 is being evaluated for possible treatment in type 2 diabetes. This study is
      designed to compare LY2409021 given alone or given in combination with metformin against
      placebo the change in hemoglobin A1c after a 24-week treatment period.
    


Intervention name(s): LY2409021; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Administered Orally; Administered Orally
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Type 2 Diabetes Mellitus
New Oral Anticoagulant Therapy for the Prevention of Blood Clots Following Hip or Knee Replacement Surgery
Condition: Total Knee Replacement; Total Hip Replacement
Study type: Interventional
Phase: Phase 2

Summary: 
      LY517717 (a capsule given by mouth) is a blood thinner that may prevent blood clots from
      forming in the legs and may prevent those blood clots from traveling to the lungs. Leg and
      lung blood clots occur commonly after patients have surgery to replace a hip or knee joint.
      These clots often occur while patients are in bed in the hospital after hip or knee joint
      surgery. The purpose of this study is to test if different dose strengths (amount of drug in
      the capsules) of LY517717 can prevent blood clots from forming and to determine if LY517717
      is safe. This study will compare LY517717 to enoxaparin, another blood thinner. Enoxaparin is
      one of the standard medications given after hip or knee joint surgery.
    


Intervention name(s): LY517717; enoxaparin
Intervention type(s): Drug; Drug
Intervention MeSH terms: Enoxaparin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Prevention
Keywords: elective; primary unilateral
N-acetylcysteine in Alcohol Dependence
Condition: Alcoholism
MeSH terms: Alcoholism
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The present study is designed to find out if N-acetylcysteine works in reducing alcohol
      drinking and craving.
    

Detailed description: 
      The 2 groups (placebo and N-acetylcysteine) will be compared in a double-blind,
      placebo-controlled trial. The total study duration is 9 weeks which includes a 1-week
      screening period and an 8-week randomized study drug treatment period.
    

Intervention name(s): N-acetylcysteine; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Patients will take oral N-acetylcysteine 900 mg/day for 1 week, 1800 mg/day for 1 week, 2700 mg/day for 1 week, and then 3600 mg/day.; Patients will take oral placebo (identical matching placebo) during the study period.
Intervention MeSH terms: Acetylcysteine; N-monoacetylcystine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: N-acetylcysteine; Alcoholism; Treatment
Thermal Imaging in Old and Frail in the Community
Condition: Old Age; Debility
MeSH terms: Frailty
Study type: Interventional

Summary: 
      This study aims to test whether infrared thermal imaging using a non-touch, non-ionising,
      thermal camera system is feasible and reliable as an independent technique for thermal
      comfort assessment in older people and frail older people living in a care home and with or
      without mild cognitive impairment.
    

Detailed description: 
      Thermal comfort (TC) is a complex interaction involving physiological, social, cultural and
      clothing factors. In hospital and in care homes, health-issues (frailty, dementia,
      immobility) can affect a person's perception of TC.

      In the UK 18,000 care homes provide living-communities for approximately 400,000 people. Many
      are old/frail and vulnerable to indoor chilling. A quality indicator for a good ''home''
      environment is related to TC. However, in multiplyoccupied rooms TC varies between
      individuals. The challenge in health-assessment is in identifying ''uncomfortable'' residents
      (too hot/too cold). As TC is a subjective perception; a carer cannot reliably predict TC in
      another person.

      The objectives are to use infra-red thermal imaging (IRTI) to 'see' the body temperature map,
      to demonstrate prevalence of TC/thermal discomfort, to demonstrate whether there is
      correspondence/dissociation between TC self-report and IRTI-measured body/extremity (hand)
      temperature.

      The study aims to establish if TC can be predicted by an independent non-invasive imaging
      device

      Expected achievements are a two-way pathway to health impact:

        1. identification of eligible adults via NHS intermediary care- and awaiting care home
           residency

        2. expert guidance and collaboration with NHS partners

        3. translation of results from community to NHS setting e.g. stoke/aged care medicine for
           improved thermal care on the hospital wards Longer-term the expected achievement (5-7
           years)-working with NHS colleagues and design/product development teams is expected to
           lead towards a commercialisation pathway.
    

Intervention name(s): Infra red thermal imaging
Intervention type(s): Other
Intervention description(s): thermal image using a non-touch, non-ionising, thermal camera system
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Thermal Comfort
A Clinical Study of Systane® Lid Wipes in Brazil
Condition: Ocular Tolerance; Skin Tolerance
Study type: Interventional

Summary: 
      The purpose of this study is to verify the skin and ocular tolerance of the product Systane®
      Lid Wipes.
    


Intervention name(s): Systane® Lid Wipes
Intervention type(s): Other
Intervention description(s): Commercially-marketed, individually-packaged, pre-moistened eyelid wipe for daily cleaning
Intervention model: Single Group Assignment
Masking: Single (Participant)
Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia
Condition: Restlessness; Pain
MeSH terms: Psychomotor Agitation
Study type: Interventional
Phase: Phase 4

Summary: 
      Dexmedetomidine is a highly selective α2 adrenoreceptor agonist approved by the US FDA for
      short-term postoperative sedation and analgesia.It can also reduce the stress response
      without respiratory depression.

      In this prospective, randomized, double-blind, placebo-controlled study，we gave
      dexmedetomidine or saline placebo 1h before operations were over and assessed the effects of
      dexmedetomidine on stress response and postoperative analgesia in patients undergoing
      thoracotomy during anesthesia recovery period.
    

Detailed description: 
      Dexmedetomidine can significantly reduce the emergence agitation and postoperative pain in
      patients who received chest surgery
    

Intervention name(s): dexmedetomidine; saline placebo
Intervention type(s): Drug; Drug
Intervention description(s): In this arm,midazolam(0.03-0.05mg/kg), propofol(1.5-2.5mg/kg),sufentanil(0.6-0.82μg/kg )and rocuronium(0.8-1.0mg/kg) were used in anesthesia induction.
Anaesthesia was maintained with propofol（4-6mg kg-1h-1），remifentanil (0.1-0.2 μg kg-1 min-1）and sevoflurane（1%).Propofol was titrated to maintain intraoperative Narcotrend values between 20 and 46.
Patients in this arm received dexmedetomidine 0.2μg/kg i.v. during 10 minutes 1 hour before the end of surgery; In this arm,midazolam(0.03-0.05mg/kg), propofol(1.5-2.5mg/kg),sufentanil(0.6-0.82μg/kg )and rocuronium(0.8-1.0mg/kg) were used in anesthesia induction.
Anaesthesia was maintained with propofol（4-6mg kg-1h-1），remifentanil (0.1-0.2 μg kg-1 min-1）and sevoflurane（1%).Propofol was titrated to maintain intraoperative Narcotrend values between 20 and 46.
Patients in this arm received saline placebo of the same volume i.v. during 10 minutes 1 hour before the end of surgery
Intervention MeSH terms: Dexmedetomidine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
A Long Term Study of Clozapine in Patients With Treatment-resistant Schizophrenia
Condition: Schizophrenia
MeSH terms: Schizophrenia; Schizophrenia, Treatment-Resistant
Study type: Interventional
Phase: Phase 2

Summary: 
      Clozapine is an antipsychotic. This open study will evaluate the safety and efficacy of long
      term treatment of clozapine in patients with treatment-resistant schizophrenia.
    

Detailed description: 
      Clozapine is an antipsychotic. This open study will evaluate the safety and efficacy of long
      term treatment of clozapine in patients with treatment-resistant schizophrenia.
    

Intervention name(s): Clozapine
Intervention type(s): Drug
Other intervention name(s): Clozaril
Intervention MeSH terms: Clozapine
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Schizophrenia, treatment-resistant, clozapine