bioihbjkbjnl/mcl2 huggingface dataset:
Human Circadian Sensitivity to Very Short Light Pulses
Condition: Circadian Rhythm Disorders
MeSH terms: Chronobiology Disorders
Study type: Interventional

Summary: 
      The mammalian eye serves both visual and non-image-forming functions. New information about
      the non-image-forming anatomy and physiology of the eye has revealed effects of ocular light
      stimuli on human circadian rhythms, melatonin suppression, heart rate, pupillary reflexes,
      cognitive performance, alertness and sleep. The results of the proposed work can be used to
      make predictions about the effects of light, to make recommendations involving exposure to or
      avoidance of light, and to design environmental lighting, resulting in improved health and
      alertness and decreased errors and accidents.
    


Intervention name(s): Ocular light or darkness exposure
Intervention type(s): Other
Intervention description(s): Ocular light or darkness exposure
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Circadian rhythms; Melatonin; Ocular light exposure; Darkness Exposure; Performance; Alertness
A Test of Different Degrees of Cost Sharing on Program Uptake and Attendance
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional

Summary: 
      To test the uptake of four different cost sharing discounts for enrolling in the Weight
      Watchers weight loss program as well as outcomes (program attendance and weight loss) over 12
      months.
    


Intervention name(s): Different levels of cost sharing
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Obesity; Weight loss program; incentives
Implant Placement Using a Newly Designed Single Drill Versus Conventional Sequential Drills
Condition: Implant Complication
Study type: Interventional

Summary: 
      dental implants are usually placed by sequential set of drills which could increase the time
      of the surgery and could raise the temperature of the osteotomy preparation so a new drill
      was designed to place the implants fast and easy way
    

Detailed description: 
      Dental implant success is evident nowadays with the predictable functional and aesthetic
      results obtained . Simplified techniques and approaches are preferred for the convenience of
      both the patients and operators . Current research is focusing on decreasing the number of
      instruments used, shortening of the operation time and performing flapless approaches for
      implant placement whenever possible. This is done to reduce the postoperative complaints,
      such as pain, swelling and bleeding; thus decreasing the need for analgesics and minimising
      the occurrence of morbidity .
    

Intervention name(s): drill
Intervention type(s): Other
Intervention description(s): single 3.25 mm stainless steel drill
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: implants
Study of Mometasone Furoate/Formoterol Fumarate Inhalation Combination in Healthy Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will compare the performance of three combination metered dose inhalation devices
      and the variability of mometasone and formoterol doses delivered to the lungs in a healthy
      volunteer population
    


Intervention name(s): Mometasone furoate; Formoterol fumarate
Intervention type(s): Drug; Drug
Intervention MeSH terms: Mometasone Furoate; Formoterol Fumarate
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Dose proportionality; pharmacokinetics; mometasone; formoterol; Healthy volunteers study
Work Place Health Promotion: a Change Project
Condition: Health Prevention
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine if intelligent physical exercise training can
      increase the productivity of office workers in Denmark. Effects of intervention is measured
      after 1 and 2 years.

      The project is driven as a change project.

      The investigators measure productivity as:

        -  Individual health

        -  Sick leave

        -  Retention at the workplace
    


Intervention name(s): Intelligent physical activity
Intervention type(s): Behavioral
Intervention description(s): 30 minutes of moderate activity 6 days a week and 45 minutes of high intensity training 1 day a week. Moderate activity is monitored in diaries and high intensity training is monitored by a trainer.
Other intervention name(s): Change project; Productivity
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Health Services Research
M5 vs. M6 Comparison Study With a Sub Study Into the Dielectric Constant of Aspirated Cyst Fluid
Condition: Breast Cyst; Breast Cancer Female
MeSH terms: Cysts; Breast Cyst
Study type: Interventional

Summary: 
      The MARIA breast imaging system is a Conformité Européenne (CE)-marked radio-frequency (RF)
      medical imaging device. The system employs an electromagnetic imaging technique that exploits
      the dielectric contrast between normal and cancerous tissues. The performance and imaging
      characteristic differences between the M5 and M6 versions of MARIA are not yet well
      demonstrated in the clinical environment, particularly with regards to cysts. The evaluation
      of some aspects of this potentially important new technology will occur in this comparative
      technical study. Further, the dielectric constant of cyst fluid is currently not well
      understood and obtaining readings from aspirated cyst fluid in applicable patients will be
      attempted.
    


Intervention name(s): MARIA scan
Intervention type(s): Device
Intervention description(s): The MARIA breast imaging system comprises of a scanning unit, housed under a patient bed. The scanning unit houses a hemispherical array, into which varying sizes of insert are fitted to ensure a close fit to the breast. The patient lies prone on the bed with their breast pendulous through an aperture in the bed and the scanning unit is risen to meet the breast. The fit is non-compressing and the scanner does not use ionising radiation.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: breast; cancer; breast cancer; imaging
Sargramostim for Myeloid Dendritic Cell Deficiency
Condition: Dendritic Cell Deficiency
Study type: Interventional
Phase: Phase 1

Summary: 
      Previous studies have demonstrated a deficiency of blood dendritic cells in patients with
      kidney disease that is associated with the development of viral infections after kidney
      transplantation. We plan to test the ability of sargramostim to increase blood dendritic cell
      levels in patients with kidney disease in the hopes of developing new therapies to prevent
      viral infections after kidney transplantation.
    


Intervention name(s): Sargramostim
Intervention type(s): Drug
Intervention MeSH terms: Sargramostim
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Efficacy and Safety of HVA Regimens as Salvage Treatment in rrAML
Condition: Refractory Acute Myeloid Leukemia; Relapsed Acute Erythroid Leukemia; Salvage Treatment; HVA Regimen
MeSH terms: Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Erythroblastic, Acute
Study type: Interventional
Phase: Phase 2

Summary: 
      Up Until now, there is not well acepted treatment for relapsed/refractory (rr) acute myeloid
      luekemia (AML), which has low complete response and poor survival. According to different
      guildlines, clinical trial is the first choice for the treatment of rrAML. High expression of
      BCL-2 and hypermethylation are very important factors for drug resistance in AML. Lots of
      studies have reported combination of BCL-2 inhibitor with hypomethylating agents (HMA) showed
      a promising efficacy in elder or unfit patients with newly diagnosed AML, however, presented
      not that exciting curing effect in rrAML. It is known that overexpression of MCL-1 and BCL-XL
      is the main reason for leukemia cells being resistant to BCL2 inhibitors. Since
      Homoharringtonine (HHT) could downregulate MCL-1 and BCL-XL in leukemia cells, there might be
      a synergic effect for combination of BCL-2 inhibitors with HHT, which has been proven in the
      treatment of lymphoma. Yet, there is not a report for the use of this combination in AML. In
      this single arm multi-centers prospective study, adult patients with rrAML are included and
      treated with BCL-2 inhibitor venetoclax at a dose of 400mg per day for 14 days, combined with
      azacitidine (AZA) at a dose of 75mg/m2 per day for 7 days, and HHT 1mg/m2 per day for 7 days,
      and then the eficacy and safety of HVA regimens as salvage treatment in rrAML are assessed.
    


Intervention name(s): HVA Regimens as Salvage Treatment
Intervention type(s): Combination Product
Intervention description(s): venetoclax with a dose of 400mg per day for 14 days, combined with azacitidine (AZA) with a dose of 75mg/m2 per day for 7 days, and HHT 1mg/m2 per day for 7 days
Intervention model: Single Group Assignment
Intervention model description: Patients with rrAML are treated with HVA regimen
Masking: None (Open Label)
Primary purpose: Treatment
Assessment of Satiety Following Oral Administration of an Erythritol Sweetened Beverage
Condition: Satiety in Healthy Volunteers
Study type: Interventional

Summary: 
      Erythritol is a low calorie sugar substitute that is being increasingly used to sweeten
      beverages and other food items. Greater amounts of erythritol are required to reach the
      sweetness level of a common soft drink as compared to aspartame, resulting in higher
      osmolarity for the erythritol sweetened beverage. Since associations have been noted between
      osmolarity and satiety, investigators propose that an erythritol sweetened beverage may
      enhance satiety more than a beverage sweetened with aspartame.
    

Detailed description: 
      The effects of an erythritol sweetened beverage on satiety has yet to be specifically
      explored. In this double-blind, 2-way crossover trial, healthy volunteers will consume one of
      two beverages on each visit: either an erythritol sweetened beverage or an aspartame
      sweetened beverage. Both beverages will be prepared to the same level of sweetness.

      Timed blood samples will be collected over a period of two hours following consumption of the
      sweetened beverage. Serum total ghrelin and serum insulin will be measured from all blood
      samples. A validated hunger scale will be administered three times within the two hour
      period. Data analysis for all measures will be reported with respect to deviation from the
      initial baseline measured at time 0.
    

Intervention name(s): Erythritol; Aspartame
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Erythritol is a well tolerated, low calorie sugar alcohol that is becoming more widely used as a sugar substitute.; Aspartame is a well tolerated, commonly used artificial sweetener.
Intervention MeSH terms: Erythritol
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Erythritol; Satiety Response; Ghrelin
Evaluation of the Cutera Enlighten™ Laser With Micro-Lens Array (MLA) Handpiece Attachment
Condition: Scarring; Acne
MeSH terms: Cicatrix
Study type: Interventional

Summary: 
      The purpose of this pivotal investigation is to evaluate the efficacy and safety of the
      Cutera enlighten multi-wavelength 532 nm and 1064 nm picosecond pulse duration laser and an
      investigational micro-lens array (MLA) handpiece attachment for improvement of moderate to
      severe acne scars.
    

Detailed description: 
      This is an open-label, prospective, multicenter, pivotal study in approximately 15 male or
      female subjects, age 18 to 65 years who desire laser treatment for the improvement of
      moderate to severe acne scars. Subjects will receive laser treatments with the Cutera
      enlighten laser with the Micro-Lens Array handpiece attachment. Subjects will return to the
      site after all study treatments have been delivered for a follow-up visit at 12 weeks
      following their final study treatment.
    

Intervention name(s): Enlighten™ Laser and a MLA Attachment
Intervention type(s): Device
Intervention description(s): Subjects will receive treatments with the Cutera enlighten laser with the Micro-Lens Array handpiece attachment.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Assessing the Immunogenicity of 2 Subcutaneous Doses of CHS-1701 (Coherus Pegfilgrastim) With 2 Subcutaneous Doses Neulasta®
Condition: Immunity, Humoral
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a randomized, double-blind, 2-period parallel study in healthy subjects to assess
      immunogenicity and safety of two sequential 6 mg subcutaneous (SC) injections of CHS-1701
      compared with two sequential 6 mg SC injections of Neulasta®.
    


Intervention name(s): CHS-1701; Pegfilgrastim (Neulasta)
Intervention type(s): Drug; Drug
Other intervention name(s): Neulasta
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Danshen-Jiang-Fu Granule Prepared by Danshen From Different Producing Areas for Primary Dysmenorrhea
Condition: Primary Dysmenorrhea; Traditional Chinese Medicine
MeSH terms: Dysmenorrhea
Study type: Interventional
Phase: Early Phase 1

Summary: 
      This trial aims to compare the effect of Danshen-Jiang-Fu Granule prepared by Danshen (Salvia
      Miltiorrhiza) from different producing areas (Shandong and Sichuan) for the relief of primary
      dysmenorrhea.
    


Intervention name(s): Shandong Danshen-Jiang-Fu Granule; Sichuan Danshen-Jiang-Fu Granule
Intervention type(s): Drug; Drug
Intervention description(s): Danshen-Jiang-Fu Granule is prepared from 4 kinds of Chinese herbs including Danshen (Salvia Miltiorrhiza), Paojiang (Roasted Ginger), Xiangfu(Rhizoma Cyperi), Wuyao(Lindera Aggregata). The producing area of Danshen in Shandong Danshen-Jiang-Fu Granule is Laiwu District in Shandong province.; Danshen-Jiang-Fu Granule is prepared from 4 kinds of Chinese herbs including Danshen (Salvia Miltiorrhiza), Paojiang (Roasted Ginger), Xiangfu(Rhizoma Cyperi), Wuyao(Lindera Aggregata). The producing area of Danshen in Sichuan Danshen-Jiang-Fu Granule is Zhongjiang District in Sichuan province.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
The Effect of Uric Acid Decrement on Endothelial Function in Patients With Chronic Renal Failure
Condition: Hyperuricemia; Chronic Kidney Disease
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic; Hyperuricemia
Study type: Interventional

Summary: 
      In this prospective study, the investigators aimed to evaluate the effects of improved
      hyperuricemia, a minor cardiovascular risk factor, on endothelial dysfunction in patients
      with chronic kidney disease.
    

Detailed description: 
      Endothelial dysfunction (ED) is a key event in the development of atherosclerotic
      cardiovascular disease observed in patients with chronic kidney disease (CKD). Experimental
      models have shown that hyperuricemia causes hypertension and renin angiotensin system
      activation. In this prospective study, the investigators aimed to evaluate the effects of
      improved hyperuricemia, a minor cardiovascular risk factor, on ED in patients with CKD.
    

Intervention name(s): allopurinol
Intervention type(s): Drug
Intervention description(s): 150 mg once a day
Other intervention name(s): urikoliz
Intervention MeSH terms: Allopurinol
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Screening
Keywords: allopurinol; chronic kidney disease; endothelial dysfunction; hyperuricemia; uric acid; vascular endothelium; xanthine oxidase inhibitor
A Study to Determine if Ibuprofen in Combination With Pseudoephedrine HCl is More Effective Than Each Drug Alone in the Treatment of Nighttime Bedwetting
Condition: Enuresis
MeSH terms: Enuresis; Urinary Incontinence; Nocturnal Enuresis
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of the study is to determine if ibuprofen in combination with pseudoephedrine HCl
      in the treatment of nightime bedwetting in children is more effective than each drug alone
      and if the individual drugs are more effective than placebo.
    

Detailed description: 
      The objective of this double-blind, placebo-controlled, randomized, parallel-group study is
      to determine whether the effectiveness of ibuprofen in combination with pseudoephedrine HCl
      is greater than the individual drugs alone and greater than placebo for the treatment of
      nighttime bedwetting in children. After a screening visit, parents of eligible patients are
      to record in a diary, the number of urinations and wet and dry nights. Patients then return
      and those who continue to be eligible are randomized to study medication, which they will
      take for two weeks. Patients are randomized into four treatment groups, and the dose of
      treatment medication is determined based on body weight. The four treatment groups are: 12.5
      mg of ibuprofen suspension/kg of body weight (200-450 mg of ibuprofen) plus 15 mg or 30 mg of
      pseudoephedrine HCl, 12.5 mg of ibuprofen suspension / kg of body weight (200 - 450 mg of
      ibuprofen) plus placebo suspension, or two doses of placebo suspension. The primary efficacy
      measurement is the mean reduction in wet nights, for the 14-day baseline period to the 14-day
      treatment period. Safety assessments consist of monitoring adverse events, physical
      examination and assessment of vital signs. The study hypothesis is that ibuprofen in
      combination with pseudoephedrine HCl has a greater effect in the treatment of nighttime
      bedwetting than either ibuprofen or pseudoephedrine HCl alone, and the combination is well
      tolerated. Treatment medication are an oral suspension, expressed as mg/kg body weight.
      Patients will receive 1 of 4 treatments for 2 weeks: ibuprofen (12.5 mg/kg of body weight)
      plus 15 or 30 mg of pseudoephedrine, ibuprofen (12.5 mg/kg of body weight) + placebo, 15 or
      30 mg of pseudoephedrine, or placebo
    

Intervention name(s): ibuprofen; pseudoephedrine HCl
Intervention type(s): Drug
Intervention MeSH terms: Ibuprofen; Pseudoephedrine; Ephedrine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: nocturnal enuresis; bedwetting; ibuprofen
Bioavailability of Doravirine (MK-1439) Experimental Nano Formulations in Healthy Adults (MK-1439-046)
Condition: Human Immunodeficiency Virus-1 (HIV-1)
MeSH terms: Acquired Immunodeficiency Syndrome; HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      This study aims to evaluate and compare the relative bioavailability of different doravirine
      (MK-1439) experimental nano formulations (NFs) with that of a doravirine film coated tablet.
    


Intervention name(s): Treatment A: Doravirine 100 mg film coated tablet; Treatment B: Doravirine 150 mg tablet (40% drug loaded granule); Treatment C: Doravirine 150 mg tablet (30% drug loaded granule); Treatment D: Doravirine 150 mg tablet (50% drug loaded granule); Treatment E: Doravirine 100 mg tablet (30% drug loaded granule)
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): Single doravirine 100 mg film coated tablet administered orally at the start of Period 2; Single doravirine NF Type 1 dose (150 mg tablet [40% drug loaded granule]) administered orally at the start of Period 1; Single doravirine NF Type 2 dose (150 mg tablet [30% drug loaded granule])administered orally at the start of Period 3; Single doravirine NF Type 3 dose (150 mg tablet [50% drug loaded granule])administered orally at the start of Period 4; Single doravirine NF Type 4 dose (100 mg tablet [30% drug loaded granule]) administered orally at the start of Period 5
Other intervention name(s): MK-1439; MK-1439; MK-1439; MK-1439; MK-1439
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Ezetimibe (EZ)/Atorvastatin (Ator) (MK-0653C) vs. Ator in Chinese Hypercholesterolemic Participants (MK-0653C-439)
Condition: Hypercholesterolemia
MeSH terms: Hypercholesterolemia
Study type: Interventional
Phase: Phase 3

Summary: 
      This study will evaluate the EZ/Ator fixed-dose combination (FDC) tablet (MK-0653C) as second
      line Low-Density Lipoprotein - Cholesterol (LDL-C) treatment in Chinese participants. The
      primary hypothesis is that MK-0653C 10/10 mg is superior to atorvastatin 20 mg in percent
      change from baseline in LDL-C to 12 weeks after treatment.
    


Intervention name(s): EZ 10 mg/Ator 10 mg; EZ 10 mg/Ator 20 mg; Atorvastatin; Placebo for FDC EZ/Ator; Placebo for atorvastatin
Intervention type(s): Combination Product; Combination Product; Drug; Drug; Drug
Intervention description(s): FDC of EZ10 mg/Ator 10mg; FDC of EZ10 mg/Ator 20mg; Atorvastatin administered orally QD, either as two 10 mg tablets or as two 20 mg tablets; A single placebo tablet administered orally QD for 84 days; Two placebo tablets matching atorvastatin administered orally QD for 84 days
Other intervention name(s): Lipitor^®
Intervention MeSH terms: Atorvastatin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Laser Laryngeal Surgery
Condition: Otorhinolaryngologic Surgical Procedures; Laser Therapy
Study type: Interventional

Summary: 
      The purpose of this study is to investigate whether laser laryngeal surgery can be safely and
      potentially more effectively performed without the use of tracheal intubation or jet
      ventilation, under completely tubeless conditions. The patient's gas exchange will be
      supported by rapid insufflation of high-flow oxygen through specialized nasal cannula: the so
      called Transnasal Humidified Rapid- Insufflation Ventilatory Exchange (THRIVE).
    


Intervention name(s): THRIVE; Endotracheal tube
Intervention type(s): Device; Device
Intervention description(s): active nasal oxygen delivery system; Plastic tube for supporting ventilation during surgery
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: airway management; high flow nasal oxygen high flow nasal cannula THRIVE; high flow nasal cannula THRIVE; THRIVE