bioihbjkbjnl/mcl2 huggingface dataset:
Effect of ESPB on Postoperative Pain in Patients With Breast Cancer Implant Reconstruction
Condition: Mammary Cancer; Erector Spinae Plane Block; Postoperative Pain
MeSH terms: Breast Neoplasms; Pain, Postoperative
Study type: Interventional

Summary: 
      Nowadays, the incidence of breast cancer is the first number of malignant tumors, and the
      primary treatment method is surgery.With the development of medical technology and concept,
      radical mastectomy combined breast reconstruction are becoming more and more popular.But the
      reconstruction caused greater trauma and more severe postoperative pain.ESPB is a new nerve
      block method which thought to reduce pain after thoracic and breast surgery.However, there
      are few studies on radical mastectomy combined breast reconstruction. So, this randomized
      controlled study is conducted to explore its impact on postoperative pain and thus provide
      more data guidance for clinical.
    

Detailed description: 
      Patients: 100 breast cancer patients who are planned radical mastectomy combined breast
      reconstruction Intervention: General anesthesia + erector spinae plane block Control ：
      General anesthesia Outcome: NRS(Numerical rating scale) of postoperative pain at the sixth
      hour Study:RCT
    

Intervention name(s): Erector spinae plane block
Intervention type(s): Procedure
Intervention description(s): In the ESPB group, the patients were placed in the lateral decubitus position. The ultrasound probe was located in longitudinal orientation at the level of the T4 spinous process and then placed 3 cm laterally from the midline to the side involved in the surgery. The ultrasound landmarks, T4 transverse process, and the overlying trapezius, rhomboideus, and erector spinae muscles, were identified. Under aseptic conditions, an 80-mm 21-gauge block needle was inserted in-plane at an angle of 30-40° in the cranial-to-caudal direction until the tip contacted the T4 transverse process.After the hydrodissection with 2-3 mL of isotonic saline solution confirmed the correct needle tip position, the intermixture was injected in the interfascial plane between rhomboideus major and erector spinae muscle. Local anesthetic spread in a fascial longitudinal pattern deep to the erector spinae muscle was visualized using ultrasound guidance.
Other intervention name(s): Ultrasound-guided erector spinae plane block
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Mammary Cancer; implant reconstruction; erector spinae plane block; Postoperative Pain
A Study Comparing the Amounts of 2 Different Forms of Tafamidis (PF06291826), Both With and Without Food, In the Blood
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      2 different formulations of tafamidis will be compared under both fed and fasted conditions.
      Subjects will be fasted overnight or fed. After swallowing one of the tafamidis formulations,
      tafamidis blood concentrations will be measured periodically for 8 days. After 16 days,
      subjects will take a different formulation in the fed or fasted state or take the same
      formulation in the opposite feeding condition. This will be repeated, 16 days apart, until
      all subjects have taken each formulation both fed and fasted.
    


Intervention name(s): tafamidis
Intervention type(s): Drug
Intervention description(s): bioavailability study
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
BIOPROP20: Biologically Optimised IMRT for Prostate Radiotherapy Hypofractionated Radiotherapy With Intra-prostatic Boosts to Tumour Nodules in Men With Intermediate and High Risk Prostate Cancer
Condition: Prostate Cancer
MeSH terms: Prostatic Neoplasms
Study type: Interventional

Summary: 
      High dose radiotherapy is a very effective treatment for prostate cancer. However, there is
      an increased risk of side effects compared to lower dose radiotherapy. This study will
      investigate the use of dose painting radiotherapy. Dose painting radiotherapy administers a
      high dose of radiotherapy to areas of cancer inside the prostate and a lower (standard) dose
      to the rest of the prostate. This may improve control of the cancer without increasing the
      side effects. The radiotherapy is given in 20 doses, called fractions.
    

Detailed description: 
      For patients with prostate cancer which has not spread, the typical treatment is hormone
      therapy and radiotherapy.

      It is possible to identify areas within the prostate which contain a significant amount of
      cancer with functional MRI or with 18F choline PET CT scans. These areas are called Dominant
      Intraprostastic Lesions 'DILs'. Targeted prostate biopsies help to confirm scan results. The
      radiotherapy dose to the DILs is increased, whilst the rest of the prostate is treated with
      the standard dose. This technique is called dose painting or 'boost' Intensity Modulated
      Radiotherapy Treatment (IMRT).

      IMRT is given in 37 treatment doses called fractions, once a day for about 8 weeks. A
      hypofractionated schedule is the administration of the total radiotherapy treatment over a
      smaller number of fractions, at a higher dose per fraction. Recent evidence suggests that the
      idea of using a 'hypofractionated' treatment schedule is better and more convenient with a
      similar number of side effects as a regular schedule.

      In the study, 50 patients with intermediate/high risk prostate cancer suitable and fit for
      radical radiotherapy will be recruited. The patients undergo a staging functional MRI scan,
      fiducial marker insertion (required for image guided radiotherapy) and hormone therapy as per
      standard of care treatment. The choline PET CT scan and targeted prostate biopsies are
      optional. They are useful if the MRI is difficult to interpret and will be offered to
      patients if they are felt to be appropriate by the clinician. After 2 months hormone therapy
      (standard protocol) patients have a CT /MRI planning scan and undergo IMRT with 20 treatments
      (fractions).The patient will then be followed up until 24 months after they started
      radiotherapy treatment.

      The main aim is to assess the side effects related to the bladder and bowel at 18 weeks
      (acute toxicity) after starting hypofractionated IMRT.
    

Intervention name(s): Hypofractionated IMRT boost Radiotherapy
Intervention type(s): Radiation
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effects of Docosahexaenoic and Eicosapentaenoic Acids in Hypercholesterolemic Children Plus Diet on Docosahexaenoic Acid (DHA) Status
Condition: Hypercholesterolemia
MeSH terms: Hypercholesterolemia
Study type: Interventional

Summary: 
      To examine whether Docosahexaenoic Acid (DHA) and Docosahexaenoic + Eicosapentaenoic Acids
      (DHA+EPA) supplementation in addition to National Cholesterol Education Program Step I Diet
      in Hypercholesterolemic Children increases Docosahexaenoic Acid (DHA) plasma levels in the 2
      intervention groups versus placebo. Secondary outcome measure: effect of DHA and DHA+EPA
      supplementation on blood lipid profile
    

Detailed description: 
      In a double-blind placebo-controlled trial 36 hypercholesterolemic children, 3-13 years of
      age, 19 males and 17 females were put on National Cholesterol Education Program (NCEP)Step-I
      diet and randomised into 3 groups to receive 500 mg/day of purified Docosahexaenoic Acid
      (DHA), Docosahexaenoic Acid plus Eicosapentaenoic Acid (DHA+EPA) mixture (228 + 208 mg/day
      respectively), or wheat germ oil as placebo. They underwent at baseline and after a 4 month
      treatment: EPA and DHA levels in total plasma and in phospholipids, triglycerides,
      cholesteryl esters; dietary habits by food frequency questionnaire; blood lipid profile
      (total cholesterol, HDL cholesterol, triglycerides levels)
    

Intervention name(s): Docosahexaenoic acid; Docosahexaenoic acid (DHA)+ Eicosapentaenoic acid (EPA); Germ oil; National Cholesterol Education Program (NCEP) Step I Diet
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Other
Intervention description(s): Soft capsules 500 mg/each; 1 capsule/day for 4 months; Soft capsules, 228 mg DHA + 208 mg EPA /each; 1 capsule/day for 4 months; Soft capsules, 275 mg linoleic acid + 35 mg linolenic acid + 65 mg oleic acid /each; 1 capsule/day for 4 months; Dietary counselling aimed at achieving NCEP Dietary Guidelines: Total fat intake <30% of total calories, Saturated fat intake <10% of total calories, Polyunsaturated fat intake up to 10% of total calories, monounsaturated fat intake 10-15% of total calories
Other intervention name(s): DHA; DHA and EPA mixture; wheat germ oil; Dietary intervention; Dietary recommendations
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Hypercholesterolemic children; Docosahexaenoic acid; Eicosapentaenoic acid; Blood lipid profile
Postural Re-education in Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional
Phase: Phase 1

Summary: 
      The Global Postural Re-Education is a global approach for the treatment of musculoskeletal
      disease. Using specific progressive posture for stretching particular shortened chain muscle
      the method wants to equilibrate the never-ending war between static and dynamic muscles by
      guiding the patient in a particular breathing pattern to maintain a correct posture and
      feeling it.
    

Detailed description: 
      In some countries there is a physical therapy method called "Global Posture Reeducation"
      (GPR), which was developed by Philippe Emmanuel Souchard based on 20 years of clinical
      experience.The method consist to balance the miofascial tension probably responsible for an
      articular overloading. The method stretches the shortened antigravity muscles that are inside
      a different static muscles chains. GPR is a global approach that search the biomechanics
      cause in the near areas, and involves actively the patient in the postural and gestural
      changes.
    

Intervention name(s): Global Postural Re-education; Standard Exercise Training
Intervention type(s): Other; Other
Intervention description(s): The treatment in Global Postural Re-education is a global approach that seeks to identify the biomechanical cause of the problem also in other parts of the body and involves actively the patient in the postural change. Using principles like causality, globality and individuality, the treatment consists of the use for one hour of progressive active stretching posture for specific muscular chain that are shortened. Every posture is maintained for 20 minutes with controlled breathing and the use of manual traction; The exercise programme included passive lumbar flexion, pelvic tilt, strengthening of flexor muscles, strengthening of extensor muscles, spine mobilization and stretching exercises.
Other intervention name(s): GPR; SEP
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: exercise; low back pain; posture; rehabilitation
Effect of Healing Touch on the Experience of Women Undergoing Treatment for Breast Cancer
Condition: Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Interventional

Summary: 
      To learn what effect, if any, Healing Touch (a gentle, non-invasive form of energy work that
      promotes relaxation and can help manage the side effects of chemotherapy and radiation), has
      on physical symptoms, mood, and qualify of life for women undergoing treatment for breast
      cancer.
    


Intervention name(s): Healing Touch
Intervention type(s): Procedure
Intervention description(s): A gentle, non-invasive form of energy-balancing work that promotes relaxation and can help manage the side effects of chemotherapy.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Effect of Ocular Massage on the Management of Elevated Intraocular Pressure After Acute Angle Closure
Condition: Intraocular Pressure
MeSH terms: Ocular Hypertension
Study type: Interventional

Summary: 
      Lowering intraocular pressure remains the mainstay of therapy in the management of glaucoma.
      The effect of ocular massage on intraocular pressure in patients with acute primary angle
      closure was the important thing.This was a prospective study, in which 20 eyes from 20
      patients had acute angle closure. When they went to the hospital, ocular massage was
      performed without any medication. Intraocular pressure was detected by Goldmann tonometer,
      and Lenstar LS900 optical biometry observed changes of anterior chamber depth before and
      after ocular massage. Anterior chamber depth, anterior chamber angle and ciliary body were
      observed by Ultrasound biomicroscopy after massage, and anterior chamber angle was also
      checked by gonioscope after massage.
    

Detailed description: 
      Background: Primary angle closure glaucoma is still the most common type in Asia. Lowering
      intraocular pressure remains the mainstay of therapy in the management of glaucoma, since it
      has been shown to be effective in reducing optic nerve damage and loss of vision. The
      objective of this study was to evaluate to assess the effect of ocular massage on intraocular
      pressure in patients with acute primary angle closure.

      Methods : This was a prospective study, in which 20 eyes from 20 patients had acute angle
      closure. When they went to the hospital, ocular massage was performed without any medication.
      Intraocular pressure was detected by Goldmann tonometer, and Lenstar LS900 optical biometry
      (Lenstar LS900) observed changes of anterior chamber depth before and after ocular massage.
      Anterior chamber depth, anterior chamber angle and ciliary body were observed by Ultrasound
      biomicroscopy (after massage, and anterior chamber angle was also checked by gonioscope after
      massage.
    

Intervention name(s): ocular massage; LenstarLS900; Goldmann tonometer
Intervention type(s): Other; Device; Device
Intervention description(s): ocular massage could be applied over the globe over the closed eyelids with moderate massage strength for 15 minutes. The compression of the globe was given with finger, and press for 2 seconds, then by a 2 seconds release, with a frequency of 15 presses/minute.; observed changes of anterior chamber depth before and after ocular massage by LenstarLS900; observed changes of intraocular pressure before and after ocular massage by Goldmann tonometer
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: acute angle closure; ocular massage
Group Eczema Education Visits:Impact on Patient and Family Quality of Life
Condition: Eczema
MeSH terms: Eczema
Study type: Interventional

Summary: 
      The objective of this study is to determine whether group educational visits improve the
      quality of life of patients referred to the Dermatology Clinic. Secondary outcomes will be to
      determine whether group educational visits influences other key elements of patient care such
      as topical steroid usage, disease exacerbations, emergency visits, and phone calls to the
      office. Lastly, the investigators hope to evaluate which aspects of the educational visit
      were found to be the most helpful to families caring for children with atopic dermatitis
      (AD). Patients will be new atopic dermatitis referrals to OHSU dermatology and pediatric
      dermatology clinics. All consecutive patients with such appointments during a three month
      time period will be screened for participation in the study. Parents will be recruited via
      telephone. In the intervention group, parents will be invited to participate in a group
      education visit prior to their first appointment with a dermatologist. All parents in the
      study will fill out questionnaires. The children involved in the study will be assigned an
      eczema severity score during their routine visits, but this will be incorporated into the
      regular clinic assessment. The Childhood Atopic Dermatitis Impact Scale (CADIS) assesses the
      quality of life in households with children who have atopic dermatitis. The Eczema Area and
      Severity Index (EASI) measures the extent and severity of the patient's atopic dermatitis.
      The change in CADIS scores will be analyzed to determine if there is a more significant
      improvement in quality of life for the group in which parents receive the group eczema
      education visit.
    


Intervention name(s): Group eczema education session; Control group
Intervention type(s): Other; Other
Intervention description(s): Subjects in the intervention group will participate in a group education visit to discuss topics such as subjects' general understanding and knowledge of eczema and its treatment.; The control group will not attend the group eczema education session.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Group eczema education
Dissecting De-automatization
Condition: Mindfulness
Study type: Interventional

Summary: 
      The proposed study will assess the effects of mindfulness meditation training on an eye blink
      conditioning (EBC) task in a sample of novice meditators. This methodology will allow
      investigation of whether mindfulness interrupts classical conditioning through the process of
      de-automatization. Implicit learning rates, as reflective of unconscious habit formation and
      measured by the frequency of conditioned responses during the EBC, will be a main outcome of
      interest. The proposed study will also assess the effects of mindfulness meditation training
      on an emotion regulation (ER) task, with a specific focus on reappraisal of negative images
      and savoring of positive images.
    


Intervention name(s): Mindfulness Meditation Training; Active Listening
Intervention type(s): Behavioral; Behavioral
Intervention description(s): A researcher will guide participants through 5 mindfulness meditations, each lasting 11 minutes in length.; A researcher will read participants 5 selections from The Natural History of Selborne, each lasting 11 minutes in length.
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Lithium Disilicate Glass-ceramic Versus Hybrid Ceramic Superstructure Materials on Implant Stability
Condition: Prosthesis Survival
MeSH terms: Prosthesis Failure
Study type: Interventional

Summary: 
      The aim of this study is to assess the effect of the newly introduced (hybrid dental ceramic)
      superstructure materials, Vita Enamic versus IPS Emax on implant stability, patient
      satisfaction and crestal bone loss.
    

Detailed description: 
      This study will be conducted on patients requiring single implant replacement in the
      maxillary premolar area, admitted to the Outpatient Clinic of Fixed Prosthodontics
      Department, Faculty of Oral and Dental medicine, Cairo University.

      After a period of healing of 6 months, an implant abutment of accurate diameter and
      angulation will be placed to fit precisely into the internal hex of the fixture after removal
      of the cover screw. The platform matched abutment will be then secured into its final
      position using the abutment screw. Alginate impression will be taken and poured into dental
      stone. Using the impression transfers, impressions with polyvinylsiloxane are taken. After
      taking the impressions, the Impression transfers are removed and fixed to the implant
      replica.

      Surgeons' assistants will be asked to open the sealed envelope containing the information
      regarding the crown placement. The impressions will be sent to dental laboratory with the
      result of the sealed envelope, for preparation of the future crowns, either vita enamic
      crowns or Ips e max crowns.
    

Intervention name(s): Vita Enamic (hybrid dental ceramic); lithium disilicate glass-ceramic
Intervention type(s): Other; Other
Intervention description(s): Vita Enamic (hybrid dental ceramic) are provided as blocks to be milled using Computer aided design/Computer aided manufacturer (CAD/CAM) technology,; All ceramic crowns (Lithium disilicate glass ceramic) milled by Computer aided design/Computer aided manufacturer (CAD/CAM) technology
Other intervention name(s): hybrid, resin nanoceramic; Emax CAD, IPS Emax
Intervention MeSH terms: Lithium Carbonate
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: implant supported restorations; IPS Emax (lithium disilicate glass-ceramic); Vita Enamic (hybrid dental ceramic); implant survival; peri-implant tissue response
Atomoxetine for Treatment of Weight Gain in Olanzapine or Clozapine Patients
Condition: Schizophrenia
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 4

Summary: 
      The study investigates the use of Atomoxetine in combination with exercise and a diet support
      group (Weight Watchers)to treat weight gain associated with Olanzapine or clozapine. All
      patients must be adults who have been diagnosed with Schizophrenia or Schizoaffective
      Disorder.
    

Detailed description: 
      The study is a 6 month double-blind trial of atomoxetine in combination with a Weight
      Watchers group to help patients lose the weight they have gained taking olanzapine or
      clozapine. All participants should have been on Olanzapine or clozapine for at least 6 months
      and gained 7% of baseline weight or have a BMI of 27 or greater. In addition to the group
      support, participants are provided supervised exercise sessions and medical supervision.
      Previous studies of the group process alone were successful in helping patients lose weight.
      It is hoped that the addition of atomoxetine, which is known to cause appetite suppression,
      will be more effective in helping subjects lose weight. All subjects will receive either
      atomoxetine or placebo during the 6 month study.
    

Intervention name(s): Diet support group; Group counseling and exercise
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Diet support group weekly and exercise sessions 3 times/week, placebo medication; Support group weekly and exercise sessions 3 times/week for 24 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Weight loss; Support group; Exercise; Atomoxetine