Effect of Injectable Platelet Rich Fibrin on Healing and Patient Satisfaction Following Laser Gingival Depigmentation
Condition: Gingival Pigmentation
MeSH terms: Hypopigmentation
Study type: Interventional
Phase: Phase 4

Summary: 
      The objectives of the present study are to:

        1. Evaluate the effect of I-PRF injection following laser gingival depigmentation technique
           on the healing period as a primary objective.

        2. Assess patient satisfaction following the procedure in terms of pain and esthetic
           outcome as a secondary objective.
    

Detailed description: 
      Dental esthetic needs are increasing in recent years with a greater demand on pleasant
      appearance; including a healthy set of dentitions but also esthetically improved gingival
      appearance, especially when it is located in the anterior labial region. Physiologic gingival
      hyperpigmentation affects numerous people of different ethnic backgrounds.

      Gingival depigmentation is defined as a periodontal plastic surgical procedure that are aimed
      at removing the pigmented gingiva and methods aimed at masking the pigmented gingiva.
      Techniques of gingival depigmentation can be classified as; chemical methods mainly by
      ascorbic acids, surgical methods, electrosurgery, cryosurgery, radiosurgery, and lasers.

      The study was conducted on eight patients seeking treatment for their gingival
      hyperpigmentation for esthetic reasons. A total number of 16 sites of facial gingival
      hyperpigmentation were treated, two in each patient in a split mouth technique.

        -  Group I (LASER with I-PRF): Included eight sites that were treated with laser technique
           for gingival depigmentation, followed by intramucosal field injection of I-PRF (as study
           group).

        -  Group II (LASER): Included eight sites that were treated with laser technique for
           gingival depigmentation (as a control group).

      The clinical outcomes were assessed for each patient: at baseline (pre-operative),
      post-operative, one week, one month. Clinical assessment was done by measuring DOPI, clinical
      wound healing, VAS and patient satisfaction questionnaire.
    

Intervention name(s): i-PRF; Diode Laser
Intervention type(s): Biological; Procedure
Intervention description(s): Local anesthesia was achieved using field block technique.
A soft tissue diode surgical laser unit was used in a contact method using a flexible fiber optic hand piece with initiated tip.
Laser irradiation parameters were adjusted as follows: Wavelength [940 ± 10 nm], irradiation mode [contact continuous wave], Power [2 W] and 300 μm fiber tip diameter (Jokar et al., 2019).
The treatment was depigmentation by laser thin injection by I-PRF Post-operative instructions Instruct the patients to avoid tooth brushing on the day of surgical treatment to prevent mechanical trauma and allow re-epithelialization.; Local anesthesia was achieved using field block technique.
A soft tissue diode surgical laser unit was used in a contact method using a flexible fiber optic hand piece with initiated tip.
Laser irradiation parameters were adjusted as follows: Wavelength [940 ± 10 nm], irradiation mode [contact continuous wave], Power [2 W] and 300 μm fiber tip diameter (Jokar et al., 2019).
Post-operative instructions Instruct the patients to avoid tooth brushing on the day of surgical treatment to prevent mechanical trauma and allow re-epithelialization.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment