Effect of n-3 Polyunsaturated Fatty Acids Supplementation on Human Milk Composition of Lactating Women
Condition: Nursing Women
Study type: Interventional

Summary: 
      We propose to measure the LCPUFA human milk (linolenic acid, linoleic acid, docosahexaenoic
      acid, arachidonic acid) according to fatty acids nature and quantities consumed by lactating
      women
    

Detailed description: 
      n-3 and n-6 long chain polyunsaturated fatty acids (LCPUFA) are essential particularly to
      neurodevelopment of newborn infants. Many variations in essential PUFA and LCPUFA content of
      human milk are observed according to countries and dietary habits of the mothers.

      Maternal diet supplementation of LCPUFA of lactating women may increase LCPUFA human milk
      according to consensus recommendations.

      This clinical trial is performed to evaluate the effect of different of consumption of n-3
      fatty acids (linolenic acid) in different forms (oils or margarine) in the human milk
      composition.

      Each diet will last 30 days. During the first period of 15 days, the mothers will receive
      mediterranean diet based on olive oil. Then, lactating women will be randomised into four
      groups : one group will receive olive oil (standard group), one group supplemented in
      rapeseed oil, one group with n-3 margarine and one group with diet associating rapeseed oil
      and n-3 margarine.Human milk will be collected during the first breastfeeding of the day (10
      ml) at three times : Days 0 corresponding to the usual diet , at day 15 after the
      Mediterranean diet and at day 30, after the study diet.
    

Intervention name(s): nutritional intervention; nutritional intervention; nutritional intervention; nutritional intervention
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Each diet will last 30 days. During the first period of 15 days, the mothers will receive mediterranean diet based on olive oil. Then, lactating women will receive 30gr/day rapeseed oil. Human milk will be collected during the first breastfeeding of the day (10 ml) at three times : Days 0 corresponding to the usual diet , at day 15 after the Mediterranean diet and at day 30, after the study diet.; Each diet will last 30 days. During the first period of 15 days, the mothers will receive mediterranean diet based on olive oil. Then, lactating women will receive diet associating 30gr/day of rapeseed oil and n-3 margarine. Human milk will be collected during the first breastfeeding of the day (10 ml) at three times : Days 0 corresponding to the usual diet , at day 15 after the Mediterranean diet and at day 30, after the study diet.; Each diet will last 30 days. During the first period of 15 days, the mothers will receive mediterranean diet based on olive oil. Then, lactating women will receive with 30gr/day n-3 margarine. Human milk will be collected during the first breastfeeding of the day (10 ml) at three times : Days 0 corresponding to the usual diet , at day 15 after the Mediterranean diet and at day 30, after the study diet.; Each diet will last 30 days. During the first period of 15 days, the mothers will receive mediterranean diet based on olive oil. Then, lactating women receive 30gr/day olive oil (standard group. Human milk will be collected during the first breastfeeding of the day (10 ml) at three times : Days 0 corresponding to the usual diet , at day 15 after the Mediterranean diet and at day 30, after the study diet.
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: human milk; polyunsaturated fatty acids; linolenic acid; rapeseed oil