bioihbjkbjnl/mcl2 huggingface dataset:
Management of Myofascial Pain in Children With Sleep Bruxism
Condition: Bruxism
MeSH terms: Bruxism; Sleep Bruxism
Study type: Interventional

Summary: 
      This study compared the effectiveness of Kinesio tape and occlusal splint application in
      improving sleep quality and reducing myofascial pain in children with sleep bruxism.
    

Detailed description: 
      Forty-seven pediatric patients with sleep bruxism symptoms were randomly assigned into 3
      groups for treatment: Kinesio tape group (KT), Occlusal splint group (OS), and Exercise group
      (EG). The following assessments were made in all 3 groups, before the treatment and at the
      end of the 1st and 5th week: Wong-Baker Faces Pain Scale (WBFPS), measurement of maximum
      mouth opening, assessment of pressure pain threshold of the bilateral masseter and temporal
      muscles, and evaluation of temporal and masseter muscle thickness by ultrasonography.
    

Intervention name(s): Kinesio taping; Occlusal Splinting; Exercises
Intervention type(s): Other; Other; Other
Intervention description(s): Kinesio taping is a technique that involves the application of a special elastic tape to the skin to provide support to muscles and joints without restricting the body's range of motion. This method is designed to facilitate the body's natural healing process and improve muscle function while providing support and stability to muscles and joints. Kinesio tape is believed to help reduce pain, support muscles during movement, and aid in rehabilitation. It is commonly used in sports medicine and physical therapy to address a variety of musculoskeletal conditions and injuries.; Occlusal splinting, also known as a bite guard or night guard, is a removable dental appliance typically made of plastic that is custom-fitted to a patient's upper or lower teeth. It is primarily used to address issues related to teeth grinding (bruxism) or temporomandibular joint (TMJ) disorders. The splint is designed to fit over the teeth, creating a barrier between the upper and lower teeth to prevent grinding and clenching during sleep. Occlusal splints aim to reduce the impact of bruxism on the teeth and jaw, alleviate associated pain, protect the teeth from wear, and promote relaxation of the jaw muscles.; For patients with bruxism, exercises can be beneficial in managing symptoms and promoting relaxation of the jaw muscles. These exercises aim to reduce the frequency and intensity of bruxism, alleviate associated pain, and improve overall jaw function and comfort. It's important for patients to consult with healthcare professionals to determine the most appropriate exercises for their individual needs.
Intervention MeSH terms: Salicylic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Sporozoite Challenge of Polyprotein Vaccinees
Condition: Malaria, Falciparum; Malaria
MeSH terms: Malaria; Malaria, Falciparum
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This study examines the ability of two new malaria vaccines (FP9-PP and MVA-PP) to prevent
      the development of malaria infection after controlled exposure to the parasite. Volunteers
      for this trial will have received these vaccines in the preceding trial VAC027.1.
    

Detailed description: 
      Malaria infection kills over 2 million people each year. It is a major problem for those who
      live in endemic areas and for travellers. There is clearly a great need for a safe effective
      malaria vaccine.

      The purpose of this study is to test the clinical efficacy of two candidate malaria vaccines
      (FP9-PP and MVA-PP). These live viral vector vaccines were administered in a 'prime boost'
      regime in the preceding trial VAC027.1.

      Volunteers will now be exposed to 5 infective bites from mosquitoes carrying P. falciparum
      malaria.

      This trial will:

        1. Measure efficacy as the time in hours from malaria exposure to blood film positive for
           malaria parasites

        2. Examine immunogenicity before and after malaria infection

        3. Measure longer term vaccine efficacy by re-challenging any protected volunteers 6 - 12
           months later
    

Intervention name(s): FP9-PP (FP9 polyprotein); MVA-PP (Modified Virus Ankara polyprotein)
Intervention type(s): Biological; Biological
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Malaria; Vaccine; Prime-boost; Challenge
Theta Burst Stimulation for Compulsive Behavior Non-invasive Brain Stimulation Study
Condition: Compulsive Behavior; Obsessive-Compulsive Disorder
MeSH terms: Obsessive-Compulsive Disorder; Compulsive Behavior
Study type: Interventional

Summary: 
      This project seeks to identify causal neural mechanisms underlying unwanted, repetitive
      behaviors (compulsions). Using non-invasive brain stimulation coupled with practice in a
      computer task, we will modulate activity in a target brain region in two directions (up or
      down) and measure effects on compulsive behaviors and related measures. This work could
      ultimately lead to the ability to treat compulsions more effectively by targeting the regions
      of the brain that can help or hinder attempts to overcome compulsions.
    


Intervention name(s): Habit Override Practice; Transcranial Magnetic Stimulation
Intervention type(s): Behavioral; Other
Intervention description(s): Computerized "brain training" to provide practice in overriding avoidance habits.; Non-invasive method for temporary, focal stimulation of brain areas.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Buprenorphine Dosing Interval - 5
Condition: Opioid-Related Disorders
MeSH terms: Opioid-Related Disorders
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to explore the feasibility of extending the dosing interval of
      well maintained buprenorphine patients to 48 and 72 hours, leading to eventual 3 times/week
      dosing.
    


Intervention name(s): Buprenorphine
Intervention type(s): Drug
Intervention MeSH terms: Buprenorphine
Masking: Single
Primary purpose: Treatment
Comparative Effectiveness of Antibiotics for Respiratory Infections
Condition: Acute Otitis Media; Acute Sinusitis; Group A Streptococcal Pharyngitis
MeSH terms: Infections; Sinusitis; Pharyngitis; Otitis Media
Study type: Observational

Summary: 
      The purpose of this study is to identify and use patient centered outcomes to compare
      narrow-spectrum and broad-spectrum antibiotics for the treatment of common acute respiratory
      tract infections (ARTIs) in children.
    

Detailed description: 
      Outpatient, ARTIs account for the vast majority of antibiotic exposure to children, and
      roughly half of these antibiotic prescriptions are inappropriate. Although unnecessary
      antibiotic prescribing for viral infections has significantly decreased, there has been a
      substantial increase in prescribing of broad-spectrum antibiotics to treat ARTIs when
      narrow-spectrum antibiotics are indicated. Primary care providers, patients, and caregivers
      would benefit from studies assessing the implications of alternate antibiotic regimens for
      these common infections. Specifically, it remains unclear if treating common ARTIs with
      broad-spectrum antibiotics leads to an improvement in patient outcomes compared to treatment
      with narrow-spectrum antibiotics, particularly considering the increasing threat posed by
      antimicrobial resistance. Because of the lack of large comparative effectiveness studies with
      patient-centered outcomes addressing this issue, professional guidelines and expert
      recommendations are conflicting, and, as a result, practice patterns vary considerably.
      Therefore, using patient-centered outcomes, we aim to compare narrow-spectrum and
      broad-spectrum antibiotics for the treatment of common ARTIs in children. To accomplish this,
      we will perform a prospective cohort study of children receiving antibiotics for ARTI across
      a comprehensive pediatric healthcare network. We will conduct telephone interviews with
      parent's of children who receive antibiotic treatment for an ARTI. We will assess previously
      identified patient-centered outcomes included a health-related quality of life measure,
      occurrence of side effects, missed school/daycare, parent missed commitments and/or required
      additional childcare and symptoms were still present on day 3 after diagnosis.
    

Intervention name(s): Broad-spectrum antibiotics; Narrow-spectrum antibiotics
Intervention type(s): Drug; Drug
Intervention description(s): Amoxicillin-clavulanate, azithromycin, cefdinir, cefprozil, cefuroxime axetil, cefadroxil, cephalexin; Amoxicillin, Penicillin
Intervention MeSH terms: Anti-Bacterial Agents; Antibiotics, Antitubercular
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Child diagnosed with an ARTI and prescribed antibiotics during an outpatient visit in the
        CHOP primary care network.
      
Keywords: antibiotic use; effectiveness; acute respiratory infections; pediatrics
Assessing Foot Injuries in Infantry Recruits Wearing Different Boots
Condition: Blister; Abrasion; Stress Fracture; Ankle Sprain; Patellofemoral Pain Syndrome; Back Pain
MeSH terms: Patellofemoral Pain Syndrome; Blister; Ankle Injuries; Fractures, Stress; Foot Injuries
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      One hundred infantry recruits will be randomly assigned to two groups. Injuries will be
      monitored.
    

Detailed description: 
      One hundred infantry recruits will be randomly assigned to receive experimental infantry
      boots (DEFINITE-REGULATOR) or standard issued boots (modified Belleville 390 TROP).

      Overuse injuries and foot injuries will be monitored over a period of 14 weeks. The
      intervention group will wear experimental infantry boots and the controls will wear standard
      issue boots.
    

Intervention name(s): Experimental infantry boot - DEFINITE-REGULATOR; Control infantry boot
Intervention type(s): Device; Device
Intervention description(s): Training: infantry basic training in the experimental boots; Training: infantry basic training in the control boots
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Investigating Different Anticoagulants for Renal Replacement Therapy
Condition: Acute Kidney Injury
MeSH terms: Acute Kidney Injury
Study type: Interventional
Phase: Phase 4

Summary: 
      The aim of this study is to evaluate the effect of regional citrate anticoagulation within
      the scope of continuous renal replacement (CRRT) in critically ill patients with acute kidney
      injury (AKI) on filter life span and 90-day all cause mortality.
    

Detailed description: 
      Purpose of clinical trial:

      To evaluate the effect of regional citrate anticoagulation within the scope of continuous
      renal replacement (CRRT) in critically ill patients with acute kidney injury (AKI) on filter
      life span and 90-day all cause mortality.

      Patient population: critically ill patients with acute kidney injury requiring renal
      replacement therapy.

      Primary objective:

      Anticoagulation of the extracorporeal circuit is required in continuous RRT (CRRT). To this
      date, it is not clear which anticoagulant should be used for CRRT. Regional citrate
      anticoagulation (RCA) for CRRT in critically ill patients with AKI prolongs filter life span
      and reduces 90-day all cause mortality by approximately 8% (from 48% to 40%) compared to
      systemic heparin anticoagulation for CRRT
    

Intervention name(s): Heparin; Citrate
Intervention type(s): Drug; Drug
Intervention MeSH terms: Heparin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: CRRT; AKI; anticoagulation; KDIGO
Yoga for Adolescents
Condition: Yoga
Study type: Interventional

Summary: 
      Purpose: Specific effects of high-density Hatha Yoga(HY) training in adolescents have not yet
      been clarified. Aim of our study is to investigate the effects of high-density HY education
      on physical fitness, pulmonary function and quality of life in healthy adolescents. Methods:
      28 female adolescents will be randomly divided into two groups as yoga training and control
      groups. Training group will receive high-density HY training for 8 weeks, two days a week
      under the supervision of a physiotherapist and one day a week home program. Control group
      will not receive any exercise. Flexibility of individuals will be determined by sit-reach,
      back scratching, lateral flexion tests; muscular endurance by sit-ups, sit down-stand up on
      chair tests, balance by time up-go test; cardiorespiratory capacity by incremental shuttle
      walking test(ISWT) and respiratory functions by spirometry, quality of life will be
      determined by with the Quality of Life Scale for Children.
    


Intervention name(s): High Density Exercise Training Program - Yoga
Intervention type(s): Other
Intervention description(s): A total of 8 weeks will be applied in our study, each session of the high-density yoga program will be started with 10 minute pranayama (breath) exercises as it is in classical yoga as a preliminary preparation for the participation of individuals; the program will be completed by applying 10-20 minutes warming-stretching movements, 40 minutes surya namaskar (SN) sets, 20-30 minutes dynamic yoga asanas and 10 minutes savasana. Participants will be encouraged to study the perceived difficulty levels between 14 and 17 using the Borg scale during the sessions
Other intervention name(s): Yoga
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Yoga; physical fitness; adolescent; quality of life; sleep quality
Step-reduction in Older Men and Women
Condition: Older Adults; Reduced Physical Activity
Study type: Interventional

Summary: 
      This study investigates the effects of two weeks of reduced daily ambulation and a subsequent
      return to normal physical activity on metabolic health of older adults.
    

Detailed description: 
      Aging results in a progressive loss of muscle mass that is accelerated by periods of muscular
      disuse, common for older adults during hospitalization or convalescence from illness.
      Transient physical inactivity has been shown to cause muscular atrophy and impairments in
      insulin sensitivity in both younger and older adults. However, the recovery capacity of older
      adults after such physical inactivity remains unknown. This study aims to determine the
      impact of two weeks of daily step reduction to ≤1000 steps per day, an experimental model
      mimicking short-term physical inactivity, on glycemic control in older adults and further
      investigate whether older adults are able to recover from the consequences of this inactivity
      simply by returning to their habitual activity for 14 days.
    

Intervention name(s): Normal Daily Steps; Step-Reduction; Return to Normal Daily Steps
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Complete normal daily ambulation for one week; Reduce daily ambulation to fewer than 1000 steps per day for two weeks; Increase daily ambulation to 100% of normal daily step-count for two weeks
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Use of High-Frequency Jet Ventilation During Percutaneous Tracheostomy
Condition: Tracheostomy Complication; High-frequency Jet Ventilation; Percutaneous Tracheostomy
Study type: Interventional

Summary: 
      Percutaneous tracheostomy is the mouth opening of the tracheal ostium to the skin by creating
      an opening in the anterior wall of the trachea using Seldinger methods. This procedure is
      done using an endotracheal tube (ETT) or a laryngeal mask (LMA). High-frequency jet
      ventilation (HFJV) commonly used in oropharyngeal surgeries and creates an extra passage for
      the procedure. The investigators aimed to demonstrate the effective use of HFJV in
      percutaneous tracheostomy.
    

Detailed description: 
      Seventy five patients between 18-80 years of age who were hospitalized in intensive care unit
      were included in the study. The number of patients will be finalized by power analysis. whose
      written consent cannot be obtained and who undergo surgical tracheostomy for any reason will
      be excluded from the study. In addition, patients with active infection in the area of the
      procedure, bleeding diathesis and pathologies that interfere with the procedure in the
      ultrasonographic evaluation (thyroid diseases, etc.) will be excluded from the study.
      Patients will be divided into three groups as those using classical ventilation (group 1),
      HFJV (group 2) and classical laryngeal mask (group 3). Age, gender, height, BMI, ASA scores,
      presence and type of additional diseases, tracheostomy day, pre- and post-procedure blood gas
      analysis, duration of procedure, duration of anesthesia, complications during the procedure
      (bleeding , desaturation, accidental extubation, malposition, bradycardia, hypotension, etc.)
      will be recorded. Patients will be observed for mortality in the first 30 days after the
      procedure. Mortality results will be recorded.
    

Intervention name(s): Percutaneous tracheostomy
Intervention type(s): Device
Intervention description(s): Age, gender, height, BMI, ASA scores, presence and type of additional diseases, tracheostomy day, pre- and post-procedure blood gas analysis, duration of procedure, duration of anesthesia, complications during the procedure (bleeding , desaturation, accidental extubation, malposition, bradycardia, hypotension, etc.) will be recorded from intensive care follow-up. Patients will be observed for mortality in the first 30 days after the procedure. Mortality results will be recorded.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Supportive Care
Does Moderate Intensity Exercise Help Prevent Smoking Relapse Among Women?
Condition: Lung Cancer; Heart Disease; COPD
MeSH terms: Heart Diseases
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      This study compares the effects of a standard smoking cessation treatment, including one-time
      brief counseling and provision of nicotine patch plus an 8-week moderate intensity exercise
      program versus the same standard smoking cessation treatment plus equivalent contact control
      among 60 healthy women. We hypothesize that participants in the smoking cessation plus
      moderate intensity exercise condition will be more likely to quit smoking than participants
      in the smoking cessation treament plus contact control condition.
    

Detailed description: 
      This study compares the effects of a standard smoking cessation treatment, including one-time
      brief counseling and provision of nicotine patch plus an 8-week moderate intensity exercise
      program versus the same standard smoking cessation treatment plus equivalent contact control
      among 60 healthy women. A number of techniques will be used to increase compliance with the
      treatment program, thus more effectively isolating the effects of exercise. These include:
      (1) a two-week run-in period prior to randomization; (2) use of behavioral contracting prior
      to participant randomization; and (3) performance of all exercise on-site. Smoking cessation
      outcomes (continuous abstinence and point prevalence abstinence) will be verified by carbon
      monoxide and saliva cotinine. Physical activity will be evaluated by attendance at the
      supervised sessions. We hypothesize that participants in the smoking cessation plus moderate
      intensity exercise condition will be more likely to quit smoking than participants in the
      smoking cessation treament plus contact control condition.
    

Intervention name(s): Smoking cessation treatment plus moderate intensity exercise; Smoking cessation treatment plus health education
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Smoking cessation; Exercise; Nicotine Patch; Disease Prevention
Macrophage Activation Markers in COVID-19 Patients
Condition: COVID-19
MeSH terms: COVID-19
Study type: Observational

Summary: 
      This study is aiming to find the relation between the severity of COVID-19 in diabetic and
      obese patients and the high serum levels of matrix metalloproteinase-7 (MMP-7),matrix
      metalloproteinase-9 (MMP-9), TGF-β and PDGF Macrophage Activation Markers
    

Detailed description: 
      Acute respiratory distress syndrome (ARDS) commonly occurs in COVID-19 patients who are
      diabetic and obese, ARDS is characterized by inflammation and pulmonary fibrosis mediated by
      cytokines and biomarkers released from activated alveolar macrophages, also cytokine storm
      may occurs leading to multiple organ failure. These sequelae of COVID-19 disease in obese and
      diabetic patients are attributed to elevated plasma lipopolysaccharide which is the main
      activator of M1 and M2 macrophages. chronic activation of macrophages leads to production of
      profibrotic markers as transforming growth factor-β (TGF-β), platelet-derived growth factor
      (PDGF), matrix metalloproteinase-7 (MMP7) and matrix metalloproteinase-9 (MMP9) which promote
      fibrogenesis. In this research, we measure circulatory alveolar macrophage activation markers
      in COVID-19 obese patients with type 1 and type 2 diabetes.
    

Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        COVID-19 patients admitted to isolation hospital in Sohag "Sohag teaching hospital".
      
Biospecimen description: 
      Blood samples