bioihbjkbjnl/mcl2 huggingface dataset:
The Effect of Progressive Relaxation Exercise on Fatigue in Intensive Care Nurses
Condition: Intensive Care Nurse; Fatigue
MeSH terms: Fatigue
Study type: Interventional

Summary: 
      This study was planned as a randomized controlled experiment. It was aimed to examine the
      effect of progressive relaxation exercises applied to intensive care nurses on fatigue. The
      sociodemographic information of the participants will be collected with the 'Personal
      Information Form' and their fatigue levels with the 'Fatigue Severity Scale'. SPSS 22.0
      package program will be used in the analysis of the data. p<0.05 will be considered
      significant.
    

Detailed description: 
      Intensive care nurses experience high levels of fatigue due to the physically and mentally
      demanding tasks they undertake. For example; Conditions such as prolonged seizures,
      difficulty sleeping, and heavy workload trigger this fatigue. One of the non-pharmacological
      interventions used in the management of fatigue experienced by intensive care nurses is
      progressive relaxation exercise (PGE). PGE involves voluntary, continuous and systematic
      stretching and subsequent relaxation of various muscle groups and was first described by
      Jacobson in 1938. The purpose of PGE is to focus attention on skeletal muscles and relax the
      whole body. While doing the exercise, the individual feels the difference between tension and
      relaxation in the muscles. Thus, when needed, it learns to relax in order to reduce the
      tension in the muscles. In the literature, it has been shown that PGE reduces the severity of
      fatigue caused by different chronic diseases. In this context, in this study, it is aimed to
      examine the effect of progressive relaxation exercise applied to intensive care nurses on
      fatigue and to contribute to the literature and to the fatigue management of nurses in line
      with the results obtained.
    

Intervention name(s): Progressive relaxation exercise
Intervention type(s): Behavioral
Intervention description(s): It consists of sessions involving deep breathing and stretching and relaxing the body.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized controlled
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Fatigue; Intensive Care Nursing; Progressive Relaxation Exercises
Enhancing Speech Fluency With Non-invasive Brain Stimulation in Developmental Stuttering
Condition: Stuttering; Fluency Disorders; Speech Disorders
MeSH terms: Stuttering; Speech Disorders
Study type: Interventional

Summary: 
      This study aims to test whether the addition of transcranial direct current stimulation
      (TDCS) to speech fluency training results in improvements in speech fluency in adults with
      developmental stuttering. Half of the participants will receive anodal TDCS on five
      consecutive days, the other half will receive a sham stimulation for the same amount of time.
    

Detailed description: 
      Studies using TDCS have shown improvements in motor performance, and in expressive language
      skills in clinical and healthy populations. The benefits of single sessions of TDCS are
      short-lived. However, stimulation over multiple sessions can increase and prolong learning
      effects that can persist for several weeks after the end of the stimulation period. We aim to
      target left hemisphere frontal regions involved in speech production with TDCS, and to pair
      this stimulation with speech fluency training.
    

Intervention name(s): Anodal TDCS; Fluency Training
Intervention type(s): Device; Behavioral
Intervention description(s): 20 minutes 1mA anodal stimulation to left inferior frontal cortex. Cathode positioned on right supra-orbital ridge.; Speech tasks will be completed using fluency-enhancing techniques: metronome-timed speech and auditory choral speech.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Stammering; Brain stimulation
Does Ultraviolet Irradiation Reduce Platelet Reactivity and Improve Coronary Microvascular Function in Man?
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      Endothelium derived nitric oxide (NO) regulates vascular tone and blood pressure in man. NO
      also inhibits platelet aggregation and mediates a variety of beneficial anti-inflammatory and
      repair mechanisms. NO may also be a mediator in the release of the endogenous fibrinolytic
      factor, tissue-plasminogen activating factor (t-PA) from the endothelium.1 Via these actions
      it plays a very important role in protection of the vasculature from atherothrombosis and
      clinical sequelae such as myocardial infarction and stroke.

      Visible and ultraviolet (UV) light relax vascular smooth muscles by producing NO in a
      phenomenon known as photorelaxation.2 The investigators have demonstrated significant stores
      of pre-formed, bound NO and other nitrosospecies in human skin, which are rapidly released
      upon exposure to UVA.3 The investigators have demonstrated recently that serum nitrite and
      nitroso-species are increased after standing in a UVA phototherapy cabinet and that local UVA
      exposure is associated with increased forearm arterial blood flow that is independent of skin
      temperature. The investigators have also demonstrated a fall in mean arterial blood pressure
      in subjects exposed UVA.

      Cardiovascular morbidity and the prevalence of hypertension vary with latitude. The
      investigators hypothesise that some of this geographical variation may be explained by a
      diminished sunlight/UVA exposure with attendant negative effects upon NO bio-availability.4
      To further examine the potential beneficial effects of UVA exposure we will examine the
      effects of whole-body UVA upon platelet activation and upon myocardial/coronary arterial flow
      reserve. The investigators will correlate these measures with systemic nitrate, nitrite and
      nitroso-species content in healthy volunteers.

      HYPOTHESES

        1. UVA irradiation enhances coronary flow reserve in healthy volunteers.

        2. UVA irradiation suppresses platelet activation in healthy volunteers.

        3. UVA irradiation enhances the release of endogenous fibrinolytic factors in healthy
           volunteers.
    


Intervention name(s): UVA Radiation
Intervention type(s): Radiation
Intervention description(s): UVA radiation exposure for 20 minutes
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: hypertension; UV radiation; coronary flow reserve; nitric oxide
Neuromuscular Training Improves Single-Limb Stability
Condition: ACL Injury
MeSH terms: Anterior Cruciate Ligament Injuries
Study type: Interventional

Summary: 
      Pretest/post-test study design, study will try to determine if a 6-week neuromuscular
      training program designed to decrease the incidence of anterior cruciate ligament (ACL)
      injuries would improve single-limb stability in young female athletes. Healthy female high
      school athletes will participate in this study. Single-limb postural stability for both lower
      extremities will be assessed with Stork balance test, Star Excursion Balance Test for Dynamic
      Balance and Single leg stance test for static balance. Participants will be included through
      convenient sampling. Informed consent will be taken from all the participants.
    

Detailed description: 
      In this Controlled single-group pretest/post-test study design, study will try to determine
      if a 6-week neuromuscular training program designed to decrease the incidence of anterior
      cruciate ligament (ACL) injuries would improve single-limb stability in young female
      athletes. Current study hypothesized that neuromuscular training would result in an
      improvement of postural stability, with the greatest improvement taking place in the
      medial-lateral direction. Healthy female high school athletes will participate in this study.
      Single-limb postural stability for both lower extremities will be assessed with Stork balance
      test, Star Excursion Balance Test for Dynamic Balance and Single leg stance test for static
      balance. Participants will be included through convenient sampling. Informed consent will be
      taken from all the participants. Those individuals who will match the inclusion and exclusion
      criteria will be a part of the study. The neuromuscular training program will consist of
      three 90-minute training sessions per week for 6 weeks. Following the completion of the
      training program, each subject will be re-evaluated to determine change in total,
      anterior-posterior, and medial-lateral single-limb stability.
    

Intervention name(s): Strengthening, resistance exercise, plyometric and dynamic movement training
Intervention type(s): Other
Intervention description(s): (1) balance training and hip/pelvis/trunk strengthening, (2) plyometrics and dynamic movement training, and (3) resistance training.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Single limb stability; Neuromuscular Training; Female athletes; ACL
Evaluation of Patients Who Underwent Sleeve Gastrectomy With Jejunoileal Anastomosis for the Treatment of Morbid Obesity
Condition: Sleeve Gastrectomy With Jejunoileal Anastomosis
MeSH terms: Obesity; Obesity, Morbid
Study type: Observational

Summary: 
      Laparoscopic sleeve gastrectomy operations performed for morbid obesity are among the most
      common methods in the world. Gastric or intestinal bypass surgery with or without sleeve
      gastrectomy is thought to be more effective in controlling both weight loss and metabolic
      diseases. For this purpose, Roux-en-y gastric bypass, transit bipartition, duodenal switch,
      jejunoileal bypass are performed. The aim of this study was to evaluate the effects of
      jejunoileal bypass surgery on weight loss and metabolic diseases in patients with sleeve
      gastrectomy.
    

Detailed description: 
      Bariatric surgery results in more and more long-term weight loss than traditional treatment
      in moderate and severe obesity. Due to morbid obesity, jejunoileal bypass has been applied
      since 1970. Laparoscopic sleeve gastrectomy and jejunoileal anastomosis are among the rare
      techniques described in 2012. There are few studies on this technique.

      Between 2015 and 2018, jejunoileal bypass operations with laparoscopic sleeve gastrectomy for
      morbid obesity will be evaluated in Inonu University gastroenterology surgery clinic. The
      patients' age, gender, body mass index, weight loss in follow-up periods, whether there is
      back weight gain, the effects on metabolic diseases, early and late complications will be
      evaluated.
    

Intervention name(s): Sleeve gastrectomy with jejunoileal anastomosis
Intervention type(s): Procedure
Intervention description(s): The sleeve gastrectomy was performed first, after using a sealer and divider device to dissect the omentum away from the greater gastric curvature from approximately 5 cm proximal to the pylorus up to the angle of His. Excision of the fundus and the body of the stomach was then performed with a laparoscopic linear stapler upon a 36 French orogastric tube (bougie). An isoperistaltic side-to-side anastomosis between the jejunum (at 50 cm distal to the Treitz ligament) and the distal ileum ( at 200 cm proximal to the ileocecal valve) was then created using the same linear stapler with a blue cartridge (3.5 mm). A soft Penrose drain was left at the subdiaphragmatic space, and the abdominal wound was closed.
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Patients aged between 18 and 60 years with a body mass index greater than 40, no
        comorbidity or a body mass index of 35-40, with a comorbidity (diabetes mellitus,
        hypertension, obstructive sleep apnea)
      
Keywords: obesity, diabetes mellitus, bariatric surgery
ISP-TACE Versus TACE for HCC With PVTT
Condition: HCC; Portal Vein Tumor Thrombosis
MeSH terms: Thrombosis
Study type: Observational

Summary: 
      For patients with advanced hepatocellular carcinoma (HCC) and portal vein tumor thrombosis
      (PVTT), the survival benefit of transarterial chemoembolization (TACE) remains modest. This
      study aimed to investigate whether TACE in combination with irradiation stent placement (ISP)
      could prolong the survival in patients with HCC and PVTT.
    


Intervention name(s): ethiodized oil; doxorubicin;Gelfoam;; stent; idoine-125
Intervention type(s): Drug; Device
Intervention description(s): Conventional TACE was performed in both groups as follows. First, multiple angiographies were performed to detect the hepatic arterial anatomy and the possible feeding arteries of tumor, selective catheterization of the artery feeding the tumors was performed. A mixture of ethiodized oil was injected, followed by injection of Gelfoam particles.; In the ISP-TACE group, stent placement was performed one week before TACE. Under fluoroscopic and ultrasonic guidance, the outer stent was firstly placed at the site of the obstructed portal vein, and a self-expandable nitinol stent was immediately followed through a same 10-F sheath.
Intervention MeSH terms: Doxorubicin; Ethiodized Oil; Gelatin Sponge, Absorbable
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Between January 2011 and December 2016, patients with HCC and PVTT underwent TACE combined
        with irradiation stent placement or TACE monotherapy as an initial treatment at the
        authors' center were retrospectively reviewed.
      
Keywords: transarterial chemoembolization; stent; irradiation; survival; decompensation; tumor response
Carbetocin Versus Syntometrine for Prevention of Postpartum Hemorrhage After Cesarean Section
Condition: Postpartum Hemorrhage; Blood Loss
MeSH terms: Postpartum Hemorrhage; Hemorrhage
Study type: Interventional
Phase: Phase 4

Summary: 
      to compare effectiveness and tolerability of carbetocin versus syntometrine in prevention of
      Postpartum hemorrhage after cesarean section
    

Detailed description: 
      A double blind randomized study conducted on 450 pregnant subjected randomly either to single
      100 μg IV dose of carbetocin (150 women) or combination of 5 IU oxytocin and 0.2 mg
      ergometrine (300 women) after fetal extraction and before placental removal.

      Prevention of postpartum haemorrhage (PPH) after cesarean section (CS) had been evaluated by
      measurement of drop of Hemoglobin and hematocrit, incidence of PPH and number of subjects
      needed additional oxytocic
    

Intervention name(s): carbetocin; Syntometrine
Intervention type(s): Drug; Drug
Intervention description(s): Oxycontin analogue; Uterotonins
Other intervention name(s): Pabal; Oxytocin methergine combination
Intervention MeSH terms: Oxytocin; Carbetocin; Methylergonovine; Syntometrine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Keywords: Carbetocin; syntometrine; postpartum hemorrhage; cesarean section
Paclitaxel Plus Estramustine in Treating Patients With Metastatic Prostate Cancer
Condition: Prostate Cancer
MeSH terms: Prostatic Neoplasms
Study type: Interventional
Phase: Phase 2

Summary: 
      RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
      they stop growing or die. Combining more than one drug may kill more tumor cells.

      PURPOSE: Phase II trial to study the effectiveness of paclitaxel plus estramustine in
      treating patients who have metastatic prostate cancer that has not responded to hormone
      therapy.
    

Detailed description: 
      OBJECTIVES: I. Determine the effect of weekly paclitaxel plus estramustine on PSA response in
      patients with metastatic hormone-refractory prostate cancer. II. Describe the toxic effects
      of this treatment in this patient population. III. Determine the effect of treatment on pain,
      asthenia, and quality of life. IV. Determine the objective response rate after treatment
      among the patients with bidimensionally measurable disease.

      OUTLINE: Patients receive estramustine orally twice a day on days 1-3 of each week for 6
      weeks. Patients also receive paclitaxel IV over 1 hour on day 2 of each week for 6 weeks.
      Courses repeat every 8 weeks in the absence of unacceptable toxicity and disease progression.
      Quality of life is assessed prior to treatment and at weeks 4, 8, 20, and 24. Patients are
      followed every 3 months for 2 years, every 6 months for years 2-5, and then annually
      thereafter.

      PROJECTED ACCRUAL: There will be 17-52 patients accrued into this study over 14 months.
    

Intervention name(s): estramustine phosphate sodium; paclitaxel
Intervention type(s): Drug; Drug
Intervention MeSH terms: Paclitaxel; Estramustine
Primary purpose: Treatment
Keywords: adenocarcinoma of the prostate; stage IV prostate cancer; recurrent prostate cancer
Safety and Efficacy of Propionyl-L-Carnitine in the Treatment of Peripheral Arterial Disease (Intermittent Claudication)
Condition: Peripheral Vascular Diseases; Intermittent Claudication
MeSH terms: Peripheral Arterial Disease; Peripheral Vascular Diseases; Vascular Diseases; Intermittent Claudication
Study type: Interventional
Phase: Phase 3

Summary: 
      Patients with peripheral artery disease have decreased blood flow to exercising muscle
      causing pain. This decreased blood flow to the muscle affects the level of acylcarnitines
      which in turn decreases the level of carnitine. Carnitine allows muscles to function
      properly. This study will test the safety and efficacy of Propionyl-L-Carnitine taken in
      combination with a monitored exercise training program.
    

Detailed description: 
      To test the hypothesis that Propionyl-L-Carnitine taken in combination with monitored
      exercise training may improve exercise performance the study will randomize male or female
      adults with peripheral artery disease and claudication to receive either
      Proprionyl-L-Carnitine or Placebo.
    

Intervention name(s): Propionyl-L-Carnitine; PLC
Intervention type(s): Drug; Drug
Intervention description(s): 2 grams per day for six months; 2 grams/day for six months
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Perhipheral Artery Disease; Claudication; Exercise; Intermittent Claudication due to Peripheral Artery Disease
Respiratory Rate Accuracy - Healthy Adults
Condition: Normal Respiration Patterns
Study type: Observational

Summary: 
      The objective of this study is to evaluate the Fingertip Respiratory Rate algorithm
      performance of the Nonin Medical X-100SP pulse oximetry systems with the 8300AA sensors and
      Onyx 3 fingertip oximeter. There is no treatment or interventions being performed.
    

Detailed description: 
      1. Start data collection system(s) and allow them to run 15 minutes prior to study start of
           each subject.

        2. Confirm that the subject meets inclusion/exclusion criteria and has signed the current
           IRB- approved Informed Consent Form

        3. Collect Demographic and Anthropometric Data from the subject.

        4. Place Pulse Oximetry Sensors

        5. Place nasal cannula for capnography recordings

        6. A summary of Respiratory rate protocol.

             1. Stage 1: Subject will rest quietly and breathe at a normal comfortable rate for 40
                minutes. The start and stop times will be marked on the data collection system.

             2. Stage 2: Immediately after Stage 1 is complete, the subject will start the 25
                minute paced breathing protocol which will ramp from 5-45 BPM. A computer program
                will be used to guide the subject through the stage 2 paced breathing. The start
                and stop times will be marked on the data collection system.
    

Intervention name(s): Diagnostic
Intervention type(s): Diagnostic Test
Intervention description(s): Diagnostic
Observational model: Other
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        A minimum of 30 subjects will be included in this study. The subject selection will be an
        approximately equal mix of males and females with varying skin tones. At a rate of 3-4
        subjects per day, enrollment will take approximately 7-10 days to complete.
BIIB033 Single Ascending Dose Study in Healthy Volunteer Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of the study is to evaluate the safety and tolerability of single dose
      of BIIB033 administered to healthy adult volunteers.
    

Detailed description: 
      BIIB033 is an investigational product being developed to promote remyelination in subjects
      with multiple sclerosis (MS). This healthy volunteer study will evaluate safety and
      tolerability of a single dose of BIIB033.
    

Intervention name(s): BIIB033; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Single, escalating doses of BIIB033 (8 cohorts IV, 1 cohort SC); Single dose of placebo comparator (8 cohorts IV, 1 cohort SC)
Other intervention name(s): Anti-LINGO-1 antibody
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Human volunteers
A Real-World Observational Study for the Safety and Efficacy of Baraclude in Korean Pediatric Patients With Chronic Hepatitis B
Condition: Hepatitis B
MeSH terms: Hepatitis A; Hepatitis B; Hepatitis B, Chronic; Hepatitis
Study type: Observational

Summary: 
      This is a local, prospective observational study (regulatory post marketing surveillance) to
      access the safety and effectiveness of Baraclude in Korean pediatric patients with chronic
      HBV infection who are between the ages of 2 and less than 16 years.
    


Intervention name(s): Non-interventional
Intervention type(s): Other
Intervention description(s): Non-interventional
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Participants will be enrolled with chronic hepatitis B virus (CHB)between the ages of 2 and
        less than 16 years and who will begin treatment with Baraclude.