bioihbjkbjnl/mcl2 huggingface dataset:
Testing Effect and Schizophrenia
Condition: Schizophrenia; Episodic Memory Deficits
MeSH terms: Memory Disorders; Schizophrenia
Study type: Interventional

Summary: 
      When people are tested on a previously learned material, they will latter remember it better
      even when compared to a condition where they can re-study it. This phenomenon is called
      retrieval practice and is supported by an extensive research literature mostly carried out in
      normal students. This paradigm begins to be used in cognitive remediation programs in
      patients suffering from memory difficulties.

      The objective of this study is to investigate whether retrieval practice is spared in
      patients with schizophrenia.

      If effective, this method could be used in cognitive remediation programs.

      Since episodic memory difficulties are supposed to be secondary to deficits in the
      initiation/elaboration of efficient encoding and retrieval strategies our hypothesis is that
      retrieval practice is spared in schizophrenia
    


Intervention name(s): Retrieval practice effect using word pairs and cued recall tests with feedback
Intervention type(s): Behavioral
Intervention description(s): In the first phase (encoding), people study a list of 48 word pairs non semantically associated.
Then (initial test), they recall half of word pairs or restudy the other half.
In the second phase (final test) which takes place 2 days later, they recall all the 48 the word pairs.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Schizophrenia; Episodic memory deficits
Effects of Virtual Reality-based Balance Training on Balance of Diabetic Peripheral Neuropathy Patients
Condition: Diabetic Peripheral Neuropathy
MeSH terms: Peripheral Nervous System Diseases; Diabetic Neuropathies
Study type: Interventional

Summary: 
      The study aimed to clarify the effect of virtual reality-based balance training on balance in
      patients with diabetic peripheral neuropathy compared to conventional physical therapy.
    

Detailed description: 
      A randomized control trial will be conducted at the study setting Safi Hospital Faisalabad
      after the approval of the synopsis. The study will be a single-blinded randomized control
      study. A convenient sampling technique will be used for the enrollment of the patient.
      Patient selection will be done based on defined insertion and omission criteria.

      Two groups would be made, the intervention group would receive the virtual gaming exercise
      tutoring and the control group would receive the regular physiotherapy exercises.

      The evaluation of the patients will be done at the start of the study, after six weeks, and
      after twelve weeks. Follow-up will be in the 16th weeks after the cessation of therapy.

      The patient's outcome will be measured on Berg Balance Scale and the Single Leg Stance test
      and the patient's data will be recorded before and after treatment, comparisons between
      before the treatment and after the treatment data will be made after 12 weeks. Informed
      consent/approval would be taken from each patient. Analysis and entry of data will be done by
      Statistical Package of Social Sciences Version 22 Software.
    

Intervention name(s): Virtual Reality; Conventional Physical Therapy
Intervention type(s): Other; Other
Intervention description(s): Virtual reality workout enhances balance control, self-reported balance and mental stability in healthy and stable adults. Sensory-based exercise and the response to visual acuity can increase the patient's ability to maintain their body in a stable position.; Postural training, standing, walking, and walking activities are included in the conventional physical therapy in domain of balance exercise training programs. These activities are usually boring and tedious because these exercises are repeated many times.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Virtual Reality; Balance Training; Balance; Diabetic Peripheral Neuropathy; Randomized Control Trial
FDA Phase IV - Commitment - Retinal Function Study
Condition: Safety
Study type: Interventional
Phase: Phase 4

Summary: 
      Vardenafil (Levitra) and Sildenafil (Viagra) are drugs that are marketed for use in patients
      with erectile dysfunction. The purpose of this study is to find out if there are any changes
      in the eye after taking at least 15 doses of Vardenafil and after two doses of Sildenafil.
      This is a double-blind study, which means that neither you nor the study doctor will know
      which treatment you are receiving. If you qualify for the study, you will receive:-
      Vardenafil 20 mg twice per week (Monday and Thursday) for a maximum of 8 weeks. There will be
      two times when this occurs during the study.- Sildenafil 200 mg/day for two days. There will
      be two times when this occurs during the study. - Placebo (a pill that looks like vardenafil
      or sildenafil but has no active ingredient).
    


Intervention name(s): Sildenafil; Placebo; Vardenafil (Levitra, BAY38-9456); Placebo
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): A1) Two dosis of 200 mg Sildenafil orally. Patients receive either A1) or A2) in cross over design with either B1) or B2).; A2) Matching Placebo orally. Patients receive either A1) or A2) in cross over design with either B1) or B2).; B1) At least 15 dosis of 20 mg Levitra orally. Patients receive either A1) or A2) in cross over design with either B1) or B2).; B2) Matching Placebo orally. Patients receive either A1) or A2) in cross over design with either B1) or B2).
Intervention MeSH terms: Sildenafil Citrate; Vardenafil Dihydrochloride
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Retina; PDE-5; Levitra; Viagra; Normal healthy volunteers for evaluation of retinal function
Obesity Intervention Program for University Students
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional

Summary: 
      The aim of this study is to determine the effect of preventive nursing interventions, which
      consist of education / practices including of healthy eating and physical activity and
      motivational messages which sent through social media to reduce obesity risk in university
      students who in the risk group for obesity.
    

Detailed description: 
      This study has been conducted with University students in Turkey. The selected 70 students
      were associated with obesity risk factors about obesity (owerveight or normal weight and they
      were in the risk group in terms of obesity according to the risk rating scales, and between
      19-24 years old) and randomly assigned to the experimental (35 students) and control group
      (35 students). Applications for the experimental group for 11 weeks about nutritional habits,
      practices for physical activity, and motivational messages sent via social media.

      Primary Outcome Measure: Nutrition-Exercise Attitude Score, Nutrition-Exercise Behavior
      Score, Exercise Benefit / Obstacle Score. We used some scales for evaluate the primary
      outcomes (The Scale of Nutrition-Exercise Attitude-Behavior, The Scale of Exercise Benefit /
      Obstacle).

      Bady Mass Index, Waist / Hip Ratio and Body fat percentage are secondary outcomes.

      The data was calculated with SPSS package program.
    

Intervention name(s): Protective Nursing Interventions for Reduction Obesity Risk
Intervention type(s): Behavioral
Intervention description(s): Applications for the experimental group for 11 weeks are grouped under three headings.
These; Nutritional habits, practices for physical activity, and motivational messages sent via social media.
Nutritional practices: Nutritional practices consist of group trainings, individual practices and collective events.
Practices for physical activity: Group trainings, group exercises, individual exercises and collective activities. Physical activity was done for 3 days per week and 45-60 minutes every seans for 8 weeks. In addition, activities such as collective nature walks and cycling have been carried out Practices through social media: For physical activity and healthy eating; Motivational messages were sent twice a week for 11 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: Obesity; Overweight; Physical Activity; Nutrition; Nursing
Correlation Between Optical Coherence Tomography Angiography and Photopic Negative Response in Patients With Glaucoma
Condition: Open Angle Glaucoma
MeSH terms: Glaucoma; Glaucoma, Open-Angle
Study type: Observational

Summary: 
      Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide.
      It is an optic neuropathy associated with progressive loss and degeneration of the retinal
      ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to
      neuroretinal rim excavation and corresponding visual field defects.
    

Detailed description: 
      Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide.
      It is an optic neuropathy associated with progressive loss and degeneration of the retinal
      ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to
      neuroretinal rim excavation and corresponding visual field defects.

      OCT Angiography (OCTA) is a promising tool for diagnosing and monitoring glaucomatous
      patients. It can evaluate glaucomatous damage and assess the ganglion cells' health by
      measuring blood flow within the optic nerve and the retina Correlation between vascular ,
      structural and functional changes of the peripapillary retinal nerve fiber (RNFL) and
      macular/ganglion cell complex (GCC) can lead to early detection of glaucomatous changes.
    

Intervention name(s): Optical Coherence Tomography- Angiography; Photopic negative response
Intervention type(s): Diagnostic Test; Diagnostic Test
Intervention description(s): Peripapillary retinal nerve fiber layer thickness, ganglion cell complex, superficial and deep capillary plexus vessel density were measured.; Both the implicit time and amplitude of PhNR were recorded.
Other intervention name(s): OCT-A; PhNR
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        One hundreds fifty-two eyes of 76 participants were included in this study, with the
        participants recruited from the outpatient glaucoma clinic of Benha University Hospital,
        EGYPT.
      
Keywords: Open angle glaucoma; Optical coherence Tomography; Photopic negative response
Healthy Volunteer Study To Assess The Bioavailability of GSK1265744 When Administered Orally Either When Fasted or Following a Meal.
Condition: HIV Infection; Infection, Human Immunodeficiency Virus
MeSH terms: Infections; Communicable Diseases; HIV Infections; Acquired Immunodeficiency Syndrome
Study type: Interventional
Phase: Phase 1

Summary: 
      To evaluate the single dose relative bioavailability of GSK1265744 10mg administered in
      either oral solution fasted, two 5mg tablets fasted, or two 5mg tablets following a moderate
      meal.
    


Intervention name(s): GSK1265744 10 mg oral solution; GSK1265744 5 mg tablet; GSK1265744 5 mg tablet
Intervention type(s): Drug; Drug; Drug
Intervention description(s): GSK1265744; GSK1265744 5mg tablet, fasted; GSK1265744 5mg tablet, fed
Other intervention name(s): GSK1265744; GSK1265744; GSK1265744
Intervention MeSH terms: Cabotegravir
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: HIV infected subjects; Healthy volunteer; GSK1265744.
Safety and Effects of Giving a New HIV Vaccine (GENEVAX-HIV) to HIV-Negative Volunteers
Condition: HIV Infections; HIV Seronegativity
MeSH terms: HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to see if it is safe to give GENEVAX-HIV, a new HIV vaccine, to
      HIV-negative volunteers. This study will also look at how this vaccine affects the immune
      system of these volunteers.
    

Detailed description: 
      In this open-label study, volunteers are given an intramuscular injection of GENEVAX-HIV
      vaccine using the Biojector 2000. Safety measures and immune response are assessed
      accordingly.
    

Intervention name(s): APL 400-003
Intervention type(s): Biological
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Injections, Intramuscular; HIV Antibodies; Immunity, Cellular; AIDS Vaccines; HIV Seronegativity; Dose-Response Relationship, Immunologic; Vaccines, DNA
Golgi Protein for HCC Diagnosis
Condition: Screening for Hepatocellular Carcinoma
MeSH terms: Carcinoma, Hepatocellular
Study type: Observational

Summary: 
      This case-control study was conducted on 90 patients who were equally divided into two
      groups. Group 1 included 45 patients with HCV-related chronic liver disease without clinical
      or radiological evidence of HCC (control group), and Group 2 included 45 patients diagnosed
      to have HCC by Triphasic abdominal CT (patient group). Serum AFP and GP73 were measured using
      ELISA technique
    


Intervention name(s): Serum Golgi Protein 73
Intervention type(s): Diagnostic Test
Intervention description(s): Serum test
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Group I: Included 45 patients with liver cirrhosis due to HCV infection. Liver cirrhosis
        was diagnosed clinically, laboratory, and radiologically. Chronic HCV infection was
        diagnosed by positive HCV antibody and positive quantitative HCV PCR.

        Group II: Included 45 patients with Hepatocellular carcinoma (HCC) on top of HCV cirrhosis
        diagnosed by two imaging modalities, abdominal ultrasound and the characteristic arterial
        enhancement and venous washout in Tri-phasic CT abdomen.
A Study to Evaluate the Safety, Tolerability and Immunogenicity of an Investigational RSV Vaccine Candidate (Ad26.RSV.preF) in Adults 18 to 50 Years of Age, and RSV-seropositive Toddlers 12 to 24 Months of Age
Condition: Respiratory Syncytial Viruses; Respiratory Tract Infections
MeSH terms: Respiratory Tract Infections
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The purpose of this study is to assess the safety and tolerability of an intramuscular
      regimen of two doses (1*10^11 viral particles [vp]) of an investigational respiratory
      syncytial virus (RSV) vaccine candidate (adenovirus serotype 26 respiratory syncytial virus
      pre-fusion conformation stabilized F protein [pre-F] [Ad26.RSV.preF]) in adults aged 18 to 50
      years and RSV-seropositive toddlers aged 12 to 24 months.
    

Detailed description: 
      The study, designed to assess the safety and tolerability of two doses given one month apart
      of Ad26.RSV.preF, an investigational RSV vaccine candidate based on a Ad26 vector expressing
      the RSV F protein, will be conducted in a double blinded manner. The study will be divided in
      two sequential cohorts: cohort 0 (18-50 year-old adults) and cohort 1 (12-24 month-old RSV
      seropositive toddlers). The vaccine safety will be monitored by reporting solicited and
      unsolicited adverse events (AEs) and all serious adverse events (SAEs). The data will be
      reviewed by an independent data monitoring committee (IDMC) to assess safety data and to
      ensure the continuing safety of the participants enrolled in this study. The safety will be
      monitored throughout the study.
    

Intervention name(s): Ad26.RSV.preF (1*10^11 vp); Ad26.RSV.preF (5*10^10 vp); Placebo
Intervention type(s): Biological; Biological; Drug
Intervention description(s): Participants will receive two doses of 0.5 milliliter (mL) (1*10^11 vp) via IM route on Day 1 and 29 of Ad26.RSV.preF.; RSV seropositive participants will receive two doses of 0.25 mL (5*10^10 vp) via IM route on Day 1 and 29 of Ad26.RSV.preF.; Participants will receive either 0.5 mL (cohort 0) or 0.25 mL (cohort 1) of placebo via IM route on Day 1 and 29.
Other intervention name(s): JNJ-64400141; JNJ-64400141
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
Prehabilitation and Coronary Artery Bypass Grafting
Condition: Coronary Artery Bypass Graft
Study type: Interventional

Summary: 
      To evaluate the effects of Prehabilitation Resistance training on frailty and functional
      capacity in mild to moderate clinically frail patients awaiting Coronary Artery Bypass
      Grafting) CABG. This study will contribute to describing the effect of resistance training in
      mild to moderate frails patients and were directed to be the part of cardiac rehabilitation
      and define the effects of cardiac prehabilitation and to check whether the effects of
      resistance training or routine training is similar for quality of recovery in mild to
      moderate frails patients which undergone CABG.
    

Detailed description: 
      In literature, Coronary Artery Bypass Graft (CABG) is a form of heart surgery that redirects
      blood around clogged arteries to increase blood flow and oxygen to the heart. During CABG
      surgery, the surgeon uses a portion of a healthy vessel (either an artery or vein) from the
      leg, chest, or arm to create a bypass around the clogged artery. During CABG surgery with
      cardiopulmonary bypass, a heart-lung machine artificially maintains circulation blood and
      oxygenation while the surgeon operates on the heart. It includes exercise, lifestyle changes,
      education, and emotional support. It can help improve patient's health and enable them to
      live a more active life after the patient has had a heart attack or heart surgery or if the
      patient has long-term heart problems such as heart failure.

      The time spent waiting for cardiac surgery to be scheduled is a period of great uncertainty
      for a patient. There appears to be heightened anxiety regarding the inclusion of physical
      activity in this time period, mainly as a result of their current cardiac condition or
      diagnosis
    

Intervention name(s): Resistant training (Prehabilitation); Active Comparator: Control group
Intervention type(s): Other; Other
Intervention description(s): Resistance training (10-15 repetitions: major muscle groups of upper and lower limbs [eg, shoulder overhead press, biceps curl, knee lift, and quadriceps extension in sitting and hamstrings curl exercises], one to three sets each) for 20-60 minutes five days a week.; Conventional physiotherapy group followed basic pre-operative respiratory physiotherapy including deep breathing exercises, instructions in coughing techniques, mobilization, and active exercises of the upper limbs and thorax. Walk 30 m in the hospital ward.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: CABG; Fraility; Prehabilitation
Relative Bioavailability of Zanubrutinib Tablets Compared to Capsules and Effects of Food on the Pharmacokinetics of the Tablet in Healthy Adults
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      Study to assess the relative bioavailability of zanubrutinib tablets compared to capsules and
      to evaluate the effects of food on the pharmacokinetics (PK) of the zanubrutinib tablet.
    


Intervention name(s): Zanubrutinib
Intervention type(s): Drug
Intervention description(s): Administered orally as a tablet or capsule
Other intervention name(s): BGB-3111; Brukinsa
Intervention MeSH terms: Zanubrutinib
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Open-label Pharmacokinetic Study of Diazoxide Choline Coated vs. Uncoated Formulations
Condition: Hypertriglyceridemia
MeSH terms: Hypertriglyceridemia
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a single-center, randomized, open-label, multi-dose crossover study assessing the
      pharmacokinetic profiles of diazoxide choline coated versus uncoated formulations in healthy
      volunteers. The primary objective is to compare the pharmacokinetic (PK) profiles of
      diazoxide choline controlled-release coated tablets versus uncoated tablets in healthy
      volunteers under fed conditions. Secondary objectives are to assess diazoxide choline
      pharmacokinetic (PK) parameters under fasted conditions, and to assess the safety and
      tolerability of diazoxide choline controlled-release coated tablets versus uncoated tablets
      in healthy volunteers.
    


Intervention name(s): Diazoxide choline; Diazoxide choline
Intervention type(s): Drug; Drug
Intervention description(s): Diazoxide choline controlled-release coated tablets versus Diazoxide choline controlled-release uncoated tablets administered orally once daily; Diazoxide choline controlled-release uncoated tablets versus Diazoxide choline controlled-release coated tablets administered orally once daily
Intervention MeSH terms: Diazoxide; Choline
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Sustaining Women's Smoking Cessation Postpartum
Condition: Lung Diseases; Cardiovascular Diseases; Heart Diseases
MeSH terms: Lung Diseases; Cardiovascular Diseases; Heart Diseases
Study type: Observational

Summary: 
      To conduct a five-year demonstration and education project to sustain smoking cessation
      postpartum by women who had stopped smoking in pregnancy.
    

Detailed description: 
      BACKGROUND:

      The results from this study were expected to demonstrate the effectiveness of a practical
      program to protect women and their families from direct and indirect smoke exposure and to
      contribute longitudinal data on change processes involved in smoking cessation, especially
      those over the maintenance, relapse, and recycling stages, in a relatively complete
      population through a critical transition.

      DESIGN NARRATIVE:

      The TLC Program, unique in its focus on the postpartum period, used a researched model of
      behavior change that matched messages and skill training with the woman's stage of change. It
      also addressed the whole family to create a supportive environment for individual change,
      included other steps for families to protect children from passive smoke and negative
      modeling, and focused on smoking and smoke exposure directly as well as through self-care and
      child-care messages. The program used innovative materials, including videotapes and
      intervention.

      The study took place in two multi-ethnic health-care sites where the research team had
      conducted previous studies. The study used a randomized mixed design with 500 women who
      smoked regularly before pregnancy and who had been abstinent for > 30 days at their 28th week
      of pregnancy. The primary outcome was abstinence at one year postpartum. Secondary outcomes
      were partner smoking status and exposure of the index baby. Self report was validated
      biochemically in samples of mothers and babies. The study design separated data collection
      from the experiments by enrolling subjects in a university-sponsored study of new mothers'
      health-care site.