bioihbjkbjnl/mcl2 huggingface dataset:
Hydration Amongst Nurses and Doctors Oncall
Condition: Dehydration
MeSH terms: Dehydration
Study type: Observational

Summary: 
      The main purpose of this study is to assess and compare the hydration status of medical and
      nursing staff and to investigate the relationship between the hydration status, cognitive
      function and serum cortisol (marker of stress).

      We hypothesise that a significant proportion of doctors and nurses will be dehydrated at the
      end of their working day. Some, as in other occupations, may be dehydrated at the start of
      their working day. This is likely to be associated with impairment in cognitive performance
      at the end of the working day compared to the beginning and expected to be more pronounced
      after a night shift. There may be less noticeable difference amongst nursing staff given the
      protected break time. Dehydration and associated impairment in cognition is of important
      clinical value as it can impact patient care. participants will be involved in the study for
      two shifts (one day and one night), aiming at 15 medical and 15 surgical nurses as well as 15
      medical (total 15 day and 15 night shifts from each group) and surgical doctors (total 15 day
      and 15 night shifts from each group). Those that do not work both day and night shifts will
      participate for only one shift and a new participant will be recruited until target number of
      shifts is achieved.
    

Detailed description: 
      End points

        1. To assess the hydration status of hospital staff nurses and doctors oncall at work by
           measuring the following:

             1. Urine and serum osmolality

             2. Urine mass produced during the shift

             3. Kidney function (U &Es)

             4. Bioimpedance measures

                2- To assess the effect of hydration on status of cognitive function and subjective
                feelings.

                3- To assess the association between hydration status on stress hormone (cortisol)
                levels.

                Inclusion criteria All medical and nursing staff working on acute medical and
                surgical admissions at the Queens Medical Centre Nottingham.

                Exclusion Criteria:

                Pregnancy Pre-existing kidney disease Patients on diuretics Unwell in the past 6
                week with acute illness that warrants hospital admission or prescribed medication.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Nurses and doctors oncall working on acute medical and surgical admissions wards at the
        Queens Medical Centre Nottingham
      
Biospecimen description: 
      Serum and urine sampling
    
Keywords: hydration; cognitive function; doctors; nurses; Nurses and Doctors oncall
Clinical Validation Study for iVue
Condition: Normal and Ocular Pathology
Study type: Observational

Summary: 
      To demonstrate clinical substantial equivalence of iVue as comparable to commercially
      available RTVue.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Volunteers with various ocular pathology or no ocular pathology.
Social Cognition in Huntington's Disease: Cognitive Study and Functional and Morphological Imaging
Condition: Huntington's Disease
MeSH terms: Huntington Disease
Study type: Interventional

Summary: 
      Huntington's disease is a rare genetic neurodegenerative disease. It is accompanied by
      movement disorders, cognitive and behavioral. The social behavior of patients are changed,
      affecting interpersonal relationships. Patients with Huntington's disease are described as
      self-centered, lacking sympathy and empathy and mentally inflexible. These behavioral
      problems can be a major source of anxiety for patients and their families. These disorders
      also have a negative impact cognitive and motor symptoms as well as the functional abilities
      and the quality of life of patients and their entourage. Authors have suggested that these
      problems could be related inter alia to social cognition disorders. This concept refers to a
      set of skills and emotional and social experiences that regulate relations between
      individuals and can explain the behavior of individuals and groups. The objective is to
      evaluate disorders of social cognition, which may account for behavioral changes in
      Huntington's disease.
    


Intervention name(s): neuropsychological test; MRI
Intervention type(s): Behavioral; Radiation
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
A Single-portal Endoscopic Approach Through Subcutaneous Tunnel for Carpal Tunnel Release
Condition: Carpal Tunnel Syndrome
MeSH terms: Carpal Tunnel Syndrome; Syndrome
Study type: Interventional

Summary: 
      Traditional endoscopic release directly accesses the carpal tunnel and thus carries a higher
      risk of nerve irritability, even nerve injury. Based on our anatomical study, the
      investigators developed a new endoscopic technique through a single-portal palm approach that
      passes superficially to palmar aponeurosis, and cut the full transverse carpal ligament. The
      investigators will compared the technique with the standard dual-portal endoscopic technique.
    

Detailed description: 
      Conduct a multi-center, comparison clinical trial according to clinical Trial Reporting
      Standards (CONSORT). Patients in the single-portal group were treated with a single-portal
      palm approach that passes superficially to palmar aponeurosis and cut the full transverse
      carpal ligament. The comparison group were treated with Chow endoscopic technique. In order
      to assess efficiency of single-portal palm approach, the investigators will compared the
      technique with the standard dual-portal endoscopic technique. The study was approved by
      Shenzhen People's Hospital and informed consent was signed.
    

Intervention name(s): a single-portal palm approach
Intervention type(s): Procedure
Intervention description(s): a single-portal palm approach that passes superficially to palmar aponeurosis, and cut the full transverse carpal ligament.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Carpal tunnel syndrome; carpal tunnel release; pain; nerve compression syndromes
Study of 9cUAB30 in Healthy Participants
Condition: No Evidence of Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      This research study is looking at 9cUAB30 in healthy participants. Studying samples of blood
      and urine from healthy participants may help doctors learn more about how 9cUAB30 is used by
      the body.
    

Detailed description: 
      PRIMARY OBJECTIVES:

      I. To characterize the single-dose pharmacokinetics of 9cUAB30 in healthy volunteers.

      SECONDARY OBJECTIVES:

      I. To determine the toxicities of this drug in these participants. II. To correlate the
      pharmacokinetics with the toxicity of this drug in these participants.

      OUTLINE:

      Participants receive a single dose of oral 9cUAB30 on day 1. Blood and urine samples are
      collected at baseline, periodically on day 1, and then on day 8 for pharmacokinetic studies
      by high performance liquid chromatography.

      After completion of treatment, participants are followed at days 8 and 30.
    

Intervention name(s): Laboratory Biomarker Analysis; Pharmacological Study; Retinoid 9cUAB30
Intervention type(s): Other; Other; Drug
Intervention description(s): Correlative studies; Correlative studies; Given orally
Other intervention name(s): 9cUAB30
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Identifying Risk Factors for Eczema Herpeticum in Individuals With Atopic Dermatitis
Condition: Atopic Dermatitis; Eczema Herpeticum
MeSH terms: Kaposi Varicelliform Eruption; Dermatitis, Atopic; Dermatitis; Eczema
Study type: Observational

Summary: 
      Atopic Dermatitis (AD), also known as eczema, is a skin disease that causes the skin to be
      hot, dry and scaly, and have severe itching. There are different kinds of eczema. Eczema
      herpeticum (EH) is a type of eczema that spreads due to an underlying herpes virus infection.
      The purpose of this research study is to identify the risk factors that may cause EH.
    

Detailed description: 
      AD is characterized by chronic skin inflammation and infections. It is hypothesized that AD
      is caused by irritants in the environment and that symptoms of EH become worse with stress
      and changes in hormone levels. This study will examine skin cells collected from study
      participants to determine the risk factors for EH that are present in people with AD who
      develop EH.

      This study will examine dendritic cells (DC) from the skin and blood of study participants to
      determine the differences between DCs of study participants. This study will recruit four
      types of participants:

        -  Group 1 will include participants with AD, EH, and recurrent herpes simplex virus (HSV)

        -  Group 2 will include participants with AD and recurring HSV infections but without EH

        -  Group 3 will include participants with AD but without EH or HSV infection

        -  Group 4 will include participants in good general health without AD, EH, or HSV
           infection

      At the single study visit, skin and blood collection will occur.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        People of good general health, living in Germany
      
Biospecimen description: 
      Blood and skin samples will be retained
    
Keywords: Atopic Dermatitis; Eczema Herpeticum
Comparison of Laminaria and Misoprostol for Cervical Preparation Before Second Trimester Surgical Abortion
Condition: Induced; Abortion, Nonmedical
Study type: Interventional

Summary: 
      This study compares the effectiveness of cervical preparation before second trimester
      abortion using laminaria versus vaginal Misoprostol.

      The investigators hypothesize that medical preparation of the cervix with vaginal Misoprostol
      is superior to mechanical preparation using laminaria.

      The investigators believe that medical preparation makes the procedure easier to perform,
      equally safe, without addition of pain or discomfort.
    

Detailed description: 
      This is a prospective randomized study.

      The aim of the study is to compare preparation of the cervix before surgical abortion with
      laminaria and misoprostol.

      Primary outcome measures will include:

      Initial cervical opening and the need for further dilatation at the procedure Procedure
      duration

      Difficulty score performing the abortion

      Complications during and after the procedure

      Assessment of pain, using VAS scale, and the need for analgesia before and after the
      procedure
    

Intervention name(s): Laminaria, MedGyn Products, Inc. USA.; Misoprostol
Intervention type(s): Device; Drug
Intervention description(s): Insertion of Hygroscopic laminarias into the cervical canal for preparation prior to late surgical abortion. The number of laminarias is according to the cervical compliance.; Cervical preparation with vaginal Misoprostol 600 mcg overnight the day before the abortion
Other intervention name(s): laminaria tents; Cytotec
Intervention MeSH terms: Misoprostol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: late abortion; laminaria; Misoprostol; Cervical preparation
Effect of Fluconazole on the Pharmacokinetics of Pyrotinib in Healthy Subjects
Condition: Healthy Subjects
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of the study is to evaluate the effect of fluconazole on
      pharmacokinetics of pyrotinib tablet for oral administration in healthy Chinese adult
      subjects. The secondary objective of the study is to compare the safety of pyrotinib alone
      and co-administered with fluconazole.
    


Intervention name(s): Pyrotinib；Fluconazole
Intervention type(s): Drug
Intervention description(s): Drug: Pyrotinib Participants received a single oral dose of Pyrotinib tablet on the morning of day1 in treatment period 1.
Drug: Pyrotinib/Fluconazole In treatment period 2, Participants received a single oral dose of pyrotinib tablet on the morning of day9, and received a loading dose of fluconazole capsule on day6 followed by single dose of fluconazole for oral administration from D7 to D18.
Intervention MeSH terms: Fluconazole
Intervention model: Single Group Assignment
Intervention model description: Pyrotinib alone and then combination with fluconazole
Masking: None (Open Label)
Primary purpose: Other
Crossover Study to Evaluate the Effect of Food on the Pharmacokinetics of SLC-391 in Healthy Adult Subjects
Condition: Food-drug Interaction
Study type: Interventional
Phase: Phase 1

Summary: 
      This will be a single center, Phase 1, open-label, randomized, single dose, 2-period,
      2-sequence, crossover study to evaluate the PK, safety, and tolerability of a single oral
      dose of SLC-391 under fed and fasted conditions in approximately 22 healthy male and
      non-childbearing potential female subjects.

      Subjects will be randomized in a 1:1 ratio to one of two treatment sequences with 11 subjects
      per treatment sequence. Each subject will receive both treatments (Treatment A and Treatment
      B) with a washout period of at least 7 days between successive SLC-391.
    


Intervention name(s): SLC-391
Intervention type(s): Drug
Intervention description(s): SLC-391 is an AXL inhibitor
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Subjects will be randomized in a 1:1 ratio to one of two treatment sequences with 11 subjects per treatment sequence as outlined below. Each subject will receive both treatments (Treatment A and Treatment B) with a washout period of at least 7 days between successive SLC-391 single doses.
Masking: None (Open Label)
Primary purpose: Treatment
Resistance Training on Elderly Resilience
Condition: Age Problem; Healthy Aging; Activity, Motor
Study type: Interventional

Summary: 
      Background: There is on one hand sufficient evidence showing strong association between
      resilience and self-rated successful aging. On the other hand, strength training could
      contribute the cultivation of resilience among older adults. Therefore, the current study
      aims to examine the effectiveness of resistance training on resilience among Chinese older
      adults in Hong Kong.

      Methods: This study will apply a three-group, double blinded (outcome assessors and data
      analysts), randomized controlled trial (RCT) to examine the effectiveness of the
      interventions on resilience, functional fitness, and health related quality of life
      immediately after a 16-week intervention, as well as the residual effects 12 weeks after
      completion of the interventions.

      Discussion: It is expected that resistance training is promising or even superior to aerobic
      training in the improvement of resilience. Given the limited evidence on the literature, it
      is urgently needed to explore the effects of resistance training on the improvement of
      resilience in older adults. Findings of the current study can contribute to the development
      of effective resistant training programs for the promotion of resilience among older adults.
    


Intervention name(s): Resistance training; Eight-form Yang-style Tai Chi program
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Participants will receive a 16-week resistance training program, with 3 times a week (a total of 48 training sessions) and 60 minutes per session intervention, which is adopted from the 12-week resistance training program introduced in the book "Growing Stronger: Strength Training for Older Adults" (Seguin et al., 2002), with minor modifications under the advice of Physical Fitness Association of Hong Kong, China (PFA).; The active concurrent control group will receive Eight-form Yang-style Tai Chi program which has been confirmed feasible and will be taught by the qualified coach.
Other intervention name(s): Strength training group; Tai Chi Group
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Qualified participants who have signed a consent letter will be randomly assigned into three groups by a draw of lots, in a ratio of 1:1:1. The three groups will be 1) Intervention group: Resistance training (n = 40); 2) Active concurrent control group: Eight-form Yang-style Tai Chi program (n = 40); and 3) Non-treatment control group (n = 40).
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Health Services Research
Keywords: Resistance Training; Older Adults; Ageing; Resilience; Psychological Health
Safety of Riluzole in Patients With Acute Spinal Cord Injury
Condition: Spinal Cord Injury
MeSH terms: Spinal Cord Injuries; Wounds and Injuries
Study type: Observational

Summary: 
      The purpose of the study is to find out if the use of the drug Riluzole is both safe and
      improves outcome in patients with acute traumatic spinal cord injury (SCI).
    

Detailed description: 
      The primary aim of the study is to develop acute care safety and pharmacokinetic profiles of
      riluzole in patients who have sustained a acute traumatic spinal cord injury. Secondary
      objectives are to conduct exploratory analyses of functional outcomes for purposes of
      planning a subsequent Phase II randomized study of the efficiency of Riluzole for the
      treatment of acute traumatic spinal cord injury.
    

Intervention name(s): Riluzole
Intervention type(s): Drug
Intervention description(s): 50mg PO (by mouth) every 12 hours starting within 12 hours of injury and continuing for 14 days (28 doses).
Other intervention name(s): Rilutek
Intervention MeSH terms: Riluzole
Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Admitted to a NACTN hospital
      
Biospecimen description: 
      plasma and cerebral spinal fluid
    
Keywords: spinal cord injury; riluzole; pharmacokinetics; Acute Traumatic Spinal Cord Injury
Effectiveness of Propolis Mouthwash on Gingivitis
Condition: Gingivitis
MeSH terms: Gingivitis
Study type: Interventional

Summary: 
      Mouthrinses have been in used for centuries as breath fresheners, medicaments, and
      antiseptics. Recently, propolis has caught the eyes of dentists worldwide and researches are
      being carried out to infuse the usage of propolis in the dental health care treatments. There
      is belief that propolis may have a role as a tooth decay prophylaxis and help heal oral
      ulcers. Propolis is used as mouthwash, toothpaste, oral gel, and throat lozenges because of
      its proclaimed antibacterial and anti-inflammatory properties. Propolis has shown activity
      against common periodontal microorganisms, such as Candida species and the Streptococci
      mutans in vitro studies. Till date, no study has evaluated the clinical and microbiological
      effects of Malaysian Propolis as a mouthwash. Thus, the present study is designed to evaluate
      the effectiveness of Propolis as a mouthwash in the reduction of Plaque and gingivitis.The
      aim of the study is to assess and compare the effectiveness of Propolis mouthrinse with
      Chlorhexidine mouthrinse.
    

Detailed description: 
      The Randomized Controlled Clinical study with latin-square cross-over design would be used to
      assess and compare the effectiveness of Propolis and Chlorhexidine mouthrinse on gingivitis.
      Subjects with chronic generalized gingivitis with age group of 18-30 years will be selected
      for the study as the target population. Subjects who meet the inclusion and exclusion
      criteria will be selected and screened for the plaque and gingival status before including
      them in the study. They will be randomly divided into three groups.

      Group 1: 15 subjects (Placebo mouthwash) Group 2: 15 subjects (Propolis mouthwash) Group 3:
      15 subjects (Chlorhexidine mouthwash)
    

Intervention name(s): Placebo mouthwash; Propolis mouthwash; Chlorhexidine mouthwash
Intervention type(s): Drug; Drug; Drug
Intervention description(s): After using mouthwash for 21 days, they are instructed to refrain from mouthwash for 14 days (wash out period).; After using mouthwash for 21 days, they are instructed to refrain from mouthwash for 14 days (wash out period).; After using mouthwash for 21 days, they are instructed to refrain from mouthwash for 14 days (wash out period).
Other intervention name(s): Mouthwash; Mouthwash; Mouthwash
Intervention MeSH terms: Chlorhexidine; Propolis
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Prevention
The Effect of Cysteine, Tryptophan and Tyrosine Supplements on Breast Milk
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this project is to study the effect of dietary supplementation with a natural
      health product (NHP) with a focus on its effects on its levels in breast milk.
    

Detailed description: 
      The effect of oral cysteine on its levels in breast milk and plasma will be measured in
      breast feeding mothers.

      The investigators will not be studying tryptophan and tyrosine in this study. The title is an
      overview title left over from other past studies (but the investigators are only assessing
      cysteine at this time).
    

Intervention name(s): L-Cysteine
Intervention type(s): Dietary Supplement
Intervention description(s): The trade name is New Root Herbal Inc.
Other intervention name(s): Cysteine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Postpartum; Dietary Supplements; Breastfeeding Women
Message Testing in Older Adult Smokers
Condition: Smoking; Smoking Cessation
Study type: Interventional

Summary: 
      This study is examining different messages to motivate older smokers to quit smoking.
      Participants will be current smokers, between the ages of 50-80 years old, who do not have a
      history of cognitive impairment or dementia. Participants can expect to take part in a
      one-time 30 minute online survey.
    


Intervention name(s): Flyer and video
Intervention type(s): Behavioral
Intervention description(s): Participants will view a flyer and video
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Evaluation of Safety and Efficacy of Symbicort® pMDI, With or Without Spacer, in Children (6-11 Years) With Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of the study is to compare Symbicort pMDI with and without spacer in terms of
      steroid potency, improvement of lung function and asthma symptoms in children with asthma
      (6-11 years).
    


Intervention name(s): Budesonide/formoterol pMDI 40/2.25ug + spacer; Budesonide/formoterol pMDI 40/2.25 ug
Intervention type(s): Drug; Drug
Intervention MeSH terms: Budesonide; Formoterol Fumarate; Budesonide, Formoterol Fumarate Drug Combination
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Symbicort pMDI; spacer; children