Cognitive and Emotional Skills to Aid Smoking Prevention
Condition: Tobacco Smoking
Study type: Interventional

Summary: 
      The purpose of the current proposal is to investigate the extent to which interventions
      designed to improve cognitive (working memory) and emotional (distress tolerance) regulatory
      processes enhance the effectiveness of standard no-smoking informational interventions.
      Emotional and cognitive dysregulation increases the likelihood of smoking and makes it
      particularly challenging to benefit from standard interventions. Working memory and
      associated deficits make it more difficult for individuals to utilize information from
      interventions, make judicious decisions regarding the cost and benefits of smoking, and to
      resist targeted advertising. In addition, disruptions in emotion regulatory capacities
      increase the probability of using cigarettes as a coping mechanism to self-regulate negative
      affect and stress. Individuals with affective disturbances smoke at higher rates and have
      more difficulties quitting, and are more likely to smoke as a way to reduce negative affect.
      The goal of the current project is to generate new insights and new approaches to smoking
      prevention among low-SES youth by investigating (1) the influence of known SES-related
      deficits in working memory and affect regulation on proximal measures of smoking risk, and
      (2) the potential for targeted interventions to reverse these risks. Specifically, the
      investigators examine the influence of working memory training and distress tolerance
      (mindfulness) interventions on cognitive/affective targets placing individuals at risk for
      smoking initiation and maintenance.

      The specific aims of this study are therefore to investigate:

        1. The feasibility and acceptability of school- and community-based brief interventions
           targeting working memory and distress tolerance in a diverse sample of low SES
           adolescents.

        2. The effects of working memory and distress tolerance interventions, relative to a
           standard informational intervention alone, on specific cognitive-affective targets-delay
           discounting and distress tolerance--relevant to cigarette smoking initiation and
           maintenance.

        3. The impact of cognitive /affective target activation on proximal measures of smoking
           risk/behavior and related health outcomes following intervention.
    

Detailed description: 
      Overview. The investigators are targeting a high-risk (low SES adolescents) population at a
      highly relevant period (high school) for smoking onset. The study design calls for block
      randomization of 150 non-smoking adolescents to one of three intervention conditions: (1) a
      control condition offering health education combined with a smoking prevention informational
      intervention (C+SPII), (2) a Working Memory intervention delivered prior to a smoking
      prevention informational intervention (WM+SPII), (3) a Distress Tolerance Intervention
      delivered prior to a smoking prevention informational intervention (DT+SPII). Smoking risk
      proximal outcomes are assessed by smoking propensity self-report, delay discounting, and
      implicit associations to smoking; smoking behavior is assessed at one-month follow-up.

      Research material will consist of participant self-report of smoking, peer smoking, and
      parental smoking as well as self-report of personality characteristics (e.g. sensation
      seeking) that are associated with risk behaviors. Biological data (from exhalations) is also
      sampled for analysis of CO, to confirm non-smoking status.

      Location of Interventions:

      At this writing, the investigators are awaiting funding confirmation to decide among three
      options for how we will provide the interventions at the high school. The investigators have
      thought through and planned for the following three possibilities: (1) a school-time
      intervention in selected classroom space specific to the randomized intervention, (2) an
      afterschool intervention in open classroom space, and (3) an afterschool intervention in a
      community center. The investigators prefer these options in descending order (1 to 3), but
      final negotiation of space is pending their ability to confirm with the sites that the
      investigators will indeed do the project (have obtained funding). For example, as noted in
      the application, "the headmaster of Fenway High School, Peggy Kemp, is extremely supportive
      of our work, and plans to provide both institutional and social support in our endeavor." In
      the investigators' meetings with her, she suggested that the investigators try to provide the
      intervention during the school week; noting that these interventions fit the instructional
      demands for either the home room or PE time. Use of these in-school instructional slots would
      require approval of the school superintendent, but the process of obtaining such approval
      necessarily awaits confirmation of funding. The letters of support the investigators have
      obtained documents that if they are unable to realize option #1 or option #2, they can still
      realize this project demands by utilizing option #3.

      Interventions: Participants will be randomized (using a random number table utilizing
      variable block sizes) to 1 of 3 study conditions according to two block randomization
      factors: sex and parental smoking status. Each intervention is to be delivered over eight
      consecutive weeks. Interventions are to be led by the Project Director, Dr. Eugenia Gorlin,
      with ongoing supervision from Drs. Otto and Doan. All interventions will be delivered in
      groups. Each of the study interventions is to be delivered twice a week over eight
      consecutive weeks. The school year for the targeted high school students lends itself to 8
      waves of intervention. With 30 individuals per wave (randomized to 10 in each intervention
      for any given wave), the investigators anticipate achieving our full subject pool in 5 waves.
      Group nesting will be accounted for in the analytic plan.

      The Smoking Prevention Informational Intervention (SPII) will be common to all randomized
      conditions in the study. The investigators selected the intervention from brief primary-care
      based interventions which followed the National Institutes of Health U.S. Public Health
      Service Tobacco Use and Dependence Clinical Practice Guideline. Youth will be provided with
      age-appropriate education on the norms and health consequences of smoking, affirmation of
      their non-smoking status, and help in developing a personalized strategy to maintain
      abstinence. Additionally, the investigators will incorporate a motivational interviewing
      component. Many of these elements are consistent with elements used in the youth MI program
      for adolescent smokers by Colby et al. (2005). The investigators will further incorporate
      into the SPII intervention Colby and associates' guided imagery about future
      smoking/non-smoking life status, and the initiation of our group sessions with open-ended
      exploration of the perceived likes and dislikes about smoking, and, during 4 sessions,
      provision of videotaped vignettes developed by the Massachusetts Department of Public Health
      to stimulate discussion on four content areas: health effects, social consequences,
      addiction, and financial cost. The SPII will be delivered following each of the 3 specific
      intervention conditions described in the "Study Arms" section.

      All of the groups will have 8 weeks of training sessions, with sessions scheduled twice per
      week and each lasting up to 1 hour. Snacks will be served at these training sessions. In
      addition, participants will be asked to practice class skills (e.g., 20 min of practice 3
      times a week) outside of these sessions for approximately 1 hour per week (for the memory
      program, this includes scheduling time in the computer room provided for this study).

      Data Analysis Overview:

      The following data analytic procedures are planned as of the current writing, but may be
      modified to incorporate new, more rigorous statistical modeling approaches as they become
      available.

        1. The feasibility/ acceptability of school- and community-based brief interventions will
           be assessed by recruitment and attendance rates across the study period; acceptability
           (attendance of 80% of interventions by 70% of the randomized sample) will be assessed
           across the 3 conditions.

        2. The investigators hypothesize that the WM+SPII and DT+SPII interventions, relative to
           C+SPII, will lead to higher WM and higher DT, respectively. Further, the investigators
           expect that WM will be higher in WM+SPII than in DT+SPII, and that DT will be higher in
           DT+SPII than in WM+SPII. The latter contrast will indicate if the two active treatments
           differ from each other on WM and/or DT; to perform these latter analyses, the
           investigators will replace the dummy variable contrasting WM+SPII and C+SPII, with a
           dummy variable comparing WM+SPII to DT+SPII.

        3. To evaluate the impact of cognitive/affective target activation on proximal smoking
           risk/behavior following intervention, WM and DT will both be added (simultaneously) as
           time-varying predictors of outcome in MLM models for each of the 3 measures of smoking
           risk (susceptibility to smoking, implicit attitudes toward smoking, and delay
           discounting) and for actual smoking behavior (smoking behavior is dichotomous, so it
           will be analyzed using a GLMM with a logistic linking function). The regression
           coefficients for WM and DT predicting outcome in these models will indicate the degree
           to which each is related to smoking risk over and above the other, and controlling for
           the parallel change over time between these variables and the outcomes. This approach
           calculates the relation between both WN and DT with proximal measures of smoking risk
           within subjects over time. The Benjamini-Hochberg method will be used to correct for
           multiple statistical tests.
    

Intervention name(s): Distress Tolerance Intervention; Working Memory Intervention; Control Informational Intervention
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): See arm/group description.; See arm/group description.; See arm/group description.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention