bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Adding Chickpeas to the American Diet (Long Term Study)
Condition: Inflammation
MeSH terms: Inflammation
Study type: Observational

Summary: 
      This prospective study will assess the effects of adding legumes, especially chick peas, to
      the diet of healthy adults on the commensal bacteria from feces of human subjects and
      resulting self-reported GI symptoms as well as markers of immune function.
    

Detailed description: 
      Long-term observational study:

      Subjects enrolled will participate in an observational setting for three months. During this
      time period, individuals will be encouraged, to maintain increased legume intake and explore
      new recipes that allow them to maintain a diverse menu of legume based foods. Fecal samples
      for microbiota analysis will be collected every month. Participants will record a weekly
      online questionnaire about legume intake and GI health as well as other health status
      updates. While participants will be encouraged to maintain regular intake of chickpeas
      throughout the long-term study, consumption of other legumes will be encouraged.
    

Intervention name(s): Observational Chickpea Diet
Intervention type(s): Other
Intervention description(s): Individuals encouraged to maintain increased legume intake and explore new recipes that allow them to maintain a diverse menu of legume based foods.
Fecal samples collected monthly.
Other intervention name(s): Go'Bonzo's
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Individuals directly associated with the University of Florida (faculty, staff, students)
        or through the University of Florida's Health Street program.
      
Biospecimen description: 
      Fecal
    
Keywords: Gut Microbiota
Evaluation of the Effect of Adding Corticosteroid to Viscosupplementation
Condition: Osteoarthritis
MeSH terms: Osteoarthritis
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to evaluate if the investigators can achieve better early
      outcomes adding triamcinolone to the viscosupplementation procedure.
    

Detailed description: 
      So far there is no convincing evidence that any treatment can be really effective in slowing
      or preventing the development of OA. The viscosupplementation by intraarticular injection of
      hyaluronate-derived products has gained popularity as a treatment modality of gonarthrosis.
      Today there are various papers on the treatment of gonarthrosis by intraarticular injection.
      Several methods have shown good results. There isn't, however, a consensus on the best
      method. The investigators know that in the treatment of osteoarthritis, with the
      viscosupplementation Hylan is superior in the long term, than the infiltration with
      cortisone. The good short term results achieved by infiltration of cortisone make us think
      about the combination of these drugs. The investigators will be assessing 104 patients with
      osteoarthritis of the knee, divided into two groups. Patients in group 1 will be subjected to
      infiltration procedure 6ml of Hylan. Patients in Group 2 will undergo the procedure of
      infiltration with 6ml of Hylan and 1ml (20mg) of hexacetonide Triamcinolone. The researcher
      will apply the informed consent term, the pain visual analog scale (VAS), WOMAC and Lequesne
      questionnaires. The questionnaires will be answered before infiltration (week zero), one week
      after the puncture (week 1), four weeks after (week 4) and 12 weeks after (week 12) and 24
      weeks after (week 24).
    

Intervention name(s): Hylan GF-20 alone; Triamcinolone
Intervention type(s): Drug; Drug
Intervention description(s): A intraarticular injection of 6ml of Hylan GF-20 (Synvisc); A Intraarticular injection of 6ml of Hylan GF-20 (Synvisc) + 1ml of triamcinolone (Triancil)
Other intervention name(s): Synvisc One; Synvisc One and Triancil
Intervention MeSH terms: Triamcinolone; Hyaluronic Acid; Hylan
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: viscosupplementation; intra-articular injection; hyaluronic acid; osteoarthritis; knee
Motivational Interview for Daily Living Activities in Elderly People Undergoing Total Knee Replacement
Condition: Motivation; Behavior, Health; Nursing Caries; Nurse's Role
Study type: Interventional

Summary: 
      Purpose: In this study, it was aimed to examine the effect of motivational interview on daily
      living activities on physical adaptation and quality of life in elderly people who underwent
      total knee replacement.it was aimed to examine the effect of motivational interview on daily
      living activities on physical adaptation and quality of life in elderly people who underwent
      total knee replacement.

      Design: The research was planned as a pretest, posttest, randomized controlled study in order
      to determine the effect of the motivational interviews on the life quality and physical
      activity of old patients.

      H1: After total knee replacement, the target for daily living activities is higher than the
      patients who applied the hand and those who did not.

      H2: Patients with targeted daily living activities with total knee replacement begin to get
      used to it and begin earlier than those who do not.
    


Intervention name(s): Motivational interview; Ongoing treatment
Intervention type(s): Other; Other
Intervention description(s): The motivational interviewing technique is a client-focused, directive form of counseling to create behavior change. Its main goal is to discover and solve ambivalence. This method is especially useful for people who are reluctant or ambivalent to change.; Patients with total knee replacement receive standard nurse care. Treatment is applied. He does his own exercises at home.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: motıvatıonal ıntervıew; total knee prosthesıs; old age; quality of life; physical compatibility
Effects of Combined Interventions to Optimize Recovery During High-intensity Exercises in Healthy Adults
Condition: Healthy
Study type: Interventional

Summary: 
      The objective of the study is to evaluate the effects a complex recovery intervention during
      the breaks of a repeated sprint test on exercise performance compared to placebo and control
      conditions. The enhanced recovery package (ERP) includes neck cooling with an iced gel pad,
      drinking a 6% CHO solution, mouth-rinsing with a 10% CHO, 6 mg･kg -1 caffeine solution,
      performing submaximal squats and hyperventilating a hyperoxic mixture; all applied in each
      3-min break in-between the six 30-s sprints. This intervention will be compared to a placebo
      and a control condition.
    


Intervention name(s): ERP; Placebo
Intervention type(s): Other; Other
Intervention description(s): The ERP intervention is applied in a randomized and counter-balanced order across visits 2-4 in each 3-min break in-between the six 30-s sprints, with one intervention per visit. The order and timing of the constituents of the interventions will be strictly constant within and between participants.
ERP: 1) neck cooling with an iced gel pad, 2) drinking a ∼ 6% CHO solution, 3) mouth-rinsing with a ∼10% CHO, ∼6 mg ･ kg -1 caffeine solution, 4) performing submaximal squats and 5) hyperventilating a hyperoxic mixture; The control intervention is applied in a randomized and counter-balanced order across visits 2-4 in each 3-min break in-between the six 30-s sprints, with one intervention per visit. The order and timing of the constituents of the interventions will be strictly constant within and between participants.
1) neck "cooling" with room temperature gel pack, 2) drinking an artificially sweetened solution, 3) mouth-rinsing with artificially sweetened solution (containing no caffeine), 4) performing unloaded squat manoeuvres, 5) deep breaths with room air
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Each participant will be tested on 4 different days with a control, a placebo and an interventional condition in random order.
Masking: Single (Participant)
Primary purpose: Other
Non-inferiority Study for Visual Field Measurements Using a Virtual Reality Device
Condition: Visual Field Tests
Study type: Observational

Summary: 
      It is hypothesized that performing VF measurements with a Virtual Reality headset using
      similar testing strategies as implemented in conventional perimeters, allow for a
      non-inferior quality in VF acquisitions. The results of this study will show if valid
      measurements of such devices in human subjects can be obtained.

      The primary endpoint of this study is the non-inferiority estimation quality of participant's
      mean defect (MD) measured in decibel (dB) between the head-mounted display and an OCTOPUS
      perimeter using the dynamic strategy (DS) for participants with normal or glaucomatous visual
      field. The MD is a clinical measure for the average loss of visual function calculated from
      the visual field of a participant.
    


Intervention name(s): virtual reality perimeter
Intervention type(s): Diagnostic Test
Intervention description(s): Both groups will be examined with a standard automated perimeter as well as with the virtual reality perimeter.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        The study population consists of glaucoma patients and patients with normal visual fields
        respecting the inclusion/exclusion criteria. There is no restriction in ethnicity.
      
Keywords: Perimetry; Virtual reality device
The Acute Effects of Combined Caffeine and Sodium Bicarbonate Consumption on Isometric Mid-thigh Pull
Condition: Athletes
Study type: Interventional

Summary: 
      The aim of this study was to investigate the effects of isolated and combined caffeine and
      sodium bicarbonate consumption on acute isometric mid-thigh pull (IMTP) strength, and verify
      whether they are cumulative, neutral or subtractive.
    

Detailed description: 
      Method: Nineteen Sport Sciences Faculty students (Age 23.6±1.6 years, height 171±9.4 cm,
      weight 64.3±9.6 kg, fat percentage 20.5±7.3 %, BMI 21.7±2.4 kg/m2) participated and completed
      the intervention. This study was designed as crossover, double-blind and placebo-controlled.
      Subjects participated under 5 crossover conditions: control (without supplement) (Con),
      placebo (Pla), caffeine (Caf), sodium bicarbonate (NaHCO3) and caffeine+sodium bicarbonate
      (Caf+NaHCO3). For Caf conditions, participants consumed 6 mg/kg of caffeine, obtained from
      dosing the content of 200 mg capsules. As for NaHCO3 conditions, participants consumed 0.3
      g/kg of sodium bicarbonate dissolved in water. For the combined condition, (Caf+NaHCO3),
      intake was set at 6 mg of caffeine and 0.3 g of sodium bicarbonate per kilogram of body
      weight. All supplements were consumed 60 min before the tests. Two submaximal trials of IMTP
      were performed at increasing intensities for 5 seconds (approximately %40-60 and %60-80 of
      their individually perceived 1RM, respectively, with 60-second rest intervals).
    

Intervention name(s): Performance-Enhancing Substances; Placebo; Baseline (Control)
Intervention type(s): Other; Other; Other
Intervention description(s): All supplements were consumed 60 min before the isometric mid-thigh pull tests, to reach peak blood concentrations at evaluation time. Immediately after consumption, both Control and intervention participants rested in a quiet laboratory environment (Eskişehir Technical University, Laboratory of Human Athletic Performance), until the strength tests. Participants were previously informed verbally and in writing that they should abstain from caffeine consumption (any caffeine-containing beverages and foods, such as coffee or tea, energy drinks, cocoa and cocoa-containing foods, chocolate and chocolate-containing foods or caffeine-containing drugs) for at least 24 hours before; 20gr of maltodextrin (European origin, Alfasol®, Kimbiotek, Turkey); No supplement conditions
Intervention MeSH terms: Performance-Enhancing Substances
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: subjects participated under 5 crossover conditions: control (without supplement) (Con), placebo (maltodextrin) (Pla), caffeine (Caf), sodium bicarbonate (NaHCO3) and caffeine+sodium bicarbonate (Caf+NaHCO3). The control measurement was made as a baseline measurement without supplementation.
Masking: Double (Participant, Investigator)
Primary purpose: Other
Keywords: Caffeine; Sodium Bicarbonate; Isometric Contraction; Performance-Enhancing Substances
Conventional Versus LED Phototherapy and Their Effect on Lymphocytes Subsets of Full Term Neonates With Hyperbilirubinemia
Condition: Neonatal Hyperbilirubinemia; Phototherapy Complication
MeSH terms: Hyperbilirubinemia, Neonatal; Hyperbilirubinemia
Study type: Interventional

Summary: 
      The aim of this study is to investigate the influence of the use of different types of
      phototherapy on different lymphocytes subsets CD4 and CD8 in the treatment of
      hyperbilirubinemia in neonates.
    


Intervention name(s): phototherapy
Intervention type(s): Device
Intervention description(s): estimate CD4 and CD8 subsets in neonates with unconjugated hyperbilirubinemia after exposure to phototherapy
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Comparison of Epidural and Paracostal Catheter Placement for Pain Control After Rib Fractures
Condition: Rib Fractures; Wounds and Injuries
MeSH terms: Fractures, Bone; Rib Fractures; Wounds and Injuries
Study type: Interventional

Summary: 
      The investigators plan to compare the incidence of successful placement of epidural pain
      catheters versus paracostal catheters for the control of pain and prevention of pulmonary
      complications for adult trauma patients with blunt chest wall trauma resulting in multiple
      rib fractures. When a trauma patient has > or = to 3 rib fractures on the same side, is being
      admitted to the Surgical ICU, and is encountered within 72 hours from the time of their
      injury, they will be eligible for the study. If they (or a proxy) choose to participate,
      consent will be obtained and they will randomly be assigned to receive either an epidural or
      paracostal catheter for pain control. The aim of the study is to determine if paracostal
      catheters are noninferior to epidurals for controlling pain in multisystem trauma patients.
      Secondarily the investigators will evaluate success and time of placement of the assigned
      intervention and follow the patient throughout their hospital course to compare the success
      of analgesia provided by each modality along with any complications and/or benefits of the
      two types of catheters.
    


Intervention name(s): Thoracic epidural catheter placement; Paracostal catheter placement
Intervention type(s): Other; Other
Intervention description(s): Thoracic epidurals work by delivering local anesthetics and narcotics to the epidural space, which then diffuse into the spinal nerve roots and block the transmission of pain from the chest wall to the spinal cord and brain.; Paracostal catheters run along the outer surface of the chest wall and act by delivering local anesthetics to the intercostal nerves as traverse the lower border of the ribs.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Effect of Transcutaneous Electrical Nerve Stimulation on Quadriceps Central Activation and Gait
Condition: Tibial Femoral Knee Osteoarthritis; Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional

Summary: 
      Participants diagnosed with tibial femoral knee osteoarthritis will be assigned to one of
      three treatment groups including: active transcutaneous electrical nerve stimulation (TENS),
      placebo TENS, and a control group. Assignment of conditions will be concealed. All
      participants in each of the three groups will receive physical therapy for all 4 weeks of the
      intervention. Main outcome measures will include quadriceps central activation ratio,
      quadriceps torque production, WOMAC scores, visual analog pain scores during gait as well as
      knee joint kinetics and kinematics during gait. The purpose of this study is to to determine
      if the continuous use of TENS therapy for activities of daily living and rehabilitation will
      positively impact all outcome measures.
    


Intervention name(s): Transcutaneous electrical nerve stimulation (TENS); Placebo TENS
Intervention type(s): Device; Device
Intervention description(s): Continuous TENS use; Placebo TENS use
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Tibial femoral knee osteoarthritis; Osteoarthritis
Study of Different Pain Scores in Single-Port Access (SPA) Laparoscopic Hysterectomy Versus Conventional Laparoscopic Hysterectomy
Condition: Uterine Myoma; Uterine Adenomyosis
MeSH terms: Leiomyoma; Myofibroma; Adenomyosis
Study type: Interventional
Phase: Phase 3

Summary: 
      Purpose:

      The attempt to further reduce the operative trauma in laparoscopic hysterectomy led in new
      technique such as Single-Port Access (SPA) laparoscopic surgery. This new technique is
      considered as painless procedure and better cosmetic effect but there are not any
      publications to study a possible different pain score and cosmetic effect in new techniques
      versus conventional laparoscopic hysterectomy. In this randomized controlled study the
      researchers have investigated the pain scores and cosmetic satisfaction by modified body
      image scale and cosmetic scar scale.
    


Intervention name(s): conventional laparoscopic hysterectomy; SPA laparoscopic hysterectomy
Intervention type(s): Procedure; Procedure
Intervention description(s): conventional 3 or 4 ports laparoscopic hysterectomy; single-port access laparoscopic hysterectomy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Single-port; Laparoscopy; Hysterectomy; Pain; Cosmesis; Analgesics
Use of Remote Monitoring for COVID-19 Patient
Condition: COVID
Study type: Interventional

Summary: 
      The central hypothesis motivating this study is that remote patient monitoring (RPM) of
      infectious disease patients can efficiently facilitate self-isolation. Additionally, RPM can
      assist in more rapid identification of patients at risk, facilitate detection of patient
      deterioration, and enable early interventions, all of which play a vital role in resource
      utilization and outcomes.
    

Detailed description: 
      Aim-I To develop and test a clinical care pathway that can be utilized in similar epidemic
      conditions in the future. To study this aim, the investigators will be using the COVID-19
      medical surge as a condition to evaluate the framework of delivering care through remote
      patient monitoring. The success of this care delivery model will be evaluated on ease of
      model implementation, patient satisfaction, clinical outcomes, and the utilization of shared
      decision making.

      Aim-II To evaluate remote patient monitoring for appropriate resource utilization in epidemic
      and pandemic conditions. To evaluate this aim, the investigators plan to compare the
      emergency department (ED) visits and in-patient admission of patients with and without
      wearable remote patient monitoring devices. Additionally, the investigators will compare the
      number of patients that required critical interventions (mechanical ventilation and ECMO)
      during the hospital stay.

      Aim III To evaluate the utilization of wearable technology for upfront predictions of
      patients that would require in-patient admissions. To evaluate this aim, patients who are
      diagnosed with COVID-19 and are undergoing self-quarantine will be closely monitored using a
      wearable device, and shared-clinical decisions will be made based on the monitored data and
      patient diary. The comparison group will be patients undergoing routine standard of care at
      the hospital. ED visits, in-patient hospital admissions, and patient satisfaction will be the
      outcome measures compared between the two groups.

      Aim IV To evaluate the association between early identification of critical, abnormal vital
      signs and the prevention of serious adverse events. To evaluate this aim, patients in the
      monitored group and non-monitored group will be compared for ED visits, in-patient
      admissions, length of hospital stay, and serious adverse events.
    

Intervention name(s): LifeSignals Biosensor 1AX*; Standard of Care
Intervention type(s): Device; Other
Intervention description(s): Shared-clinical decisions will be made based on the monitored data and patient diary. Two devices will be used to monitor data, LifeSignals Biosensor 1AX* and a pulse oximeter.; This group will be treated based on standard of care at our institution.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Absorption and Metabolism of Dietary Phenolics From Raspberries
Condition: Dietary Modifications
Study type: Interventional

Summary: 
      Red raspberries are a rich source of (poly)phenolic compounds, the main components being
      anthocyanins and ellagitannins. There is growing evidence linking consumption of these
      compounds with beneficial effects on human health. However, the mechanisms involved remain
      poorly understood principally because of a limited understanding of the bioavailability of
      ellagitannins and anthocyanins. This study aims to explore the identity and amounts of the
      phenolic metabolites of anthocyanins and ellagitannins in human plasma and urine following
      acute ingestion of raspberries. For this purpose ten healthy volunteers were feed 300 g of
      blended raspberries containing in total 293 μmol anthocyanins and 250 μmol ellagitannins. All
      urine excreted over 48 h after the ingestion of raspberries was collected and blood samples
      were collected before (0 h) and after raspberry consumption up to 24 h. Metabolites were
      identified and quantified by ultra high performance liquid chromatography-mass spectrometry
      (UHPLC-MS).
    


Intervention name(s): Bioavailability of Raspberry polyphenols
Intervention type(s): Other
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Raspberries; Anthocyanins; Ellagitannins; Metabolites