Epidural Dexmedetomidine vs Nalbuphine for Labor Analgesia
Condition: Epidural Anesthesia; Labor Pain
MeSH terms: Labor Pain
Study type: Interventional
Phase: Phase 2

Summary: 
      The aim of this study is to compare epidural dexmedetomidine vs nalbuphine added to
      bupivacaine in labor analgesia and determine the privilege of one over the other and to
      compare the effect of both analgesics after delivery.
    

Detailed description: 
      Labor pain often causes a strong stress response in women. Recently, it is concerned by most
      mothers and doctors that how to effectively alleviate the pain during delivery. There is no
      standard treatment for labor pain. A wide range of pharmacological and non-pharmacological
      labor pain relief techniques are available for pregnant women . Labor analgesia, also known
      as painless childbirth, refers to the use of various methods to reduce maternal labor pain or
      make it disappear. The ideal labor analgesia should be based on maternal and child safety,
      and should have fast acting, good analgesic effect and less adverse reaction. Epidural block
      anesthesia is convenient, and has less adverse reaction and obvious effect in the commonly
      used analgesic methods, which is widely used in the current way of analgesia. Dexmedetomidine
      is a highly selective α2 adrenergic receptor agonist that has sedative, hypnotic, and
      analgesic effects . Nalbuphine is a synthetic agonist antagoLabor pain often causes a strong
      stress response in women. Recently, it is concerned by most mothers and doctors that how to
      effectively alleviate the pain during delivery. There is no standard treatment for labor
      pain. A wide range of pharmacological and non-pharmacological labor pain relief techniques
      are available for pregnant women . Labor analgesia, also known as painless childbirth, refers
      to the use of various methods to reduce maternal labor pain or make it disappear. The ideal
      labor analgesia should be based on maternal and child safety, and should have fast acting,
      good analgesic effect and less adverse reaction. Epidural block anesthesia is convenient, and
      has less adverse reaction and obvious effect in the commonly used analgesic methods, which is
      widely used in the current way of analgesia. Dexmedetomidine is a highly selective α2
      adrenergic receptor agonist that has sedative, hypnotic, and analgesic effects . Nalbuphine
      is a synthetic agonist antagonist opioid that has the characteristics of mu-antagonist and
      kappa-agonist activities. Nalbuphine has gained popularity as a parenteral analgesic for
      intraoperative, postoperative, and obstetrical uses . The purpose of this study is to compare
      between the 2 drugs in decreasing labor pain. st opioid that has the characteristics of
      mu-antagonist and kappa-agonist activities. Nalbuphine has gained popularity as a parenteral
      analgesic for intraoperative, postoperative, and obstetrical uses . The purpose of this study
      is to compare between the 2 drugs in decreasing labor pain.
    

Intervention name(s): Dexmedetomidine; Nalbuphine
Intervention type(s): Drug; Drug
Intervention description(s): Dexmedetomidine, a highly selective α₂ receptor agonist, has a sympatholytic, sedative and opioid sparing effect.; Nalbuphine, a derivative of 14-hydroxymorphine is a strong analgesic with mixed k agonist and µ antagonist properties. The analgesic potency of nalbuphine has been found to be equal to morphine
Other intervention name(s): Precedex; Nalufin
Intervention MeSH terms: Dexmedetomidine; Nalbuphine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Dexmedetomidine; Nalbuphine