bioihbjkbjnl/mcl2 huggingface dataset:
Transluminal Flexible Endoscopic Procedure in Foregut and Urologic Surgery
Condition: Gastric Foreign Body, Nos; Disorder of Abdomen (Disorder); Foreign Body in Esophagus; Prostatic Diseases; Disease of Small Intestine
MeSH terms: Prostatic Diseases; Foreign Bodies
Study type: Interventional

Summary: 
      NOTES access is safe and feasible in the controlled human setting and comparable to
      standard-of-care surgical techniques. NOTES exploration of the abdomen provides adequate
      visualization comparable to laparoscopy.
    

Detailed description: 
      This is a prospective clinical trial to evaluate the feasibility of obtaining peritoneal
      cavity access from natural orifice translumenal endoscopic surgery (NOTES) during combined
      laparoscopic-endoscopic foregut surgery. Post-operative course will be compared with a
      historical chart-review control group of patients undergoing standard laparoscopic foregut
      and urologic surgery.

      The study group will be compiled by open enrollment for male and female adult subjects
      scheduled for combined laparoscopic-endoscopic surgery of the stomach, abdominal esophagus,
      prostate, bladder, proximal small intestine or who meet inclusion and exclusion criteria. The
      historical chart-review control group will be randomly chosen from patients from 2003-2006
      having undergone combined laparoscopic-endoscopic surgery of the foregut, prostate, or
      bladder and as determined by CPT coding.

      The purpose of the study is to determine if NOTES access and abdominal exploration is
      feasible, safe, offers comparable visualization to laparoscopy in a controlled human setting.
    

Intervention name(s): Natural Orifice Transluminal Endoscopic Surgery (NOTES); Natural Orifice Translumenal Endoscopic Surgery (NOTES)
Intervention type(s): Procedure; Procedure
Intervention description(s): Patients will have the standard laparoscopic procedure and the NOTES procedure will be added. The surgical procedure will require two operating teams: one led by a laparoscopic surgeon, the other by an endoscopic surgeon. During the usual course of the surgery, the flexible endoscope will be passed through the mouth urethra top gain access to the peritoneal cavity.; chart review of historical data from control group
Other intervention name(s): NOTES Surgery; NOTES Surgery
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Laparoscopic Surgical Procedures; Endoscopic Surgical Procedures; Laparoscopic & endoscopic procedures with a gastrotomy; or opening in bladder or urethra
Functional Outcome Assessment After (Calcaneal) Trauma Surgey
Condition: Fractures; Trauma; Surgery
MeSH terms: Wounds and Injuries
Study type: Observational

Summary: 
      To include patient after traumatic (calcaneal) fractures for this study. They can be included
      to analyze gait with the OFM foot model, a non invasis model. Patient will be invited to the
      movement laboratory of the MUMC. Markers will be detached with dubble sided tape on
      anatomical points. After that gait will be recorded with infra-red camera's and an animation
      model will be formed. With this model further analysis can be made to range of motion between
      different segement of the foot. These results will be compared with patient with an
      arthrodesis, healthy subjects, futher questionnaires, physical examination and radiographic
      findings will be correlated.
    

Detailed description: 
      All subjects are asked to come to the movement laboratory of Maastricht University Medical
      Centre on one individual day. Before gait analyses the following characteristics were
      measured; height, weight, BMI, knee and ankle width (measured between the two condyles of the
      knee and the measured between the two malleoli of the ankle) and leg length . All
      measurements are performed by researchers who was trained in the examination of the foot. At
      least one static trial was performed with all 42 markers, with the subjects in stance phase
      in an anatomic neutral position. After calibrating the markers and calculating the
      subject-specific joint axes in the static trial, 6 markers were removed, according to the OFM
      protocol. After that the subjects were asked to walk barefoot in normal speed after a number
      of practice trials. For this speed at least 8 proper recordings were made during walking. The
      healthy subjects were also asked to walk in slow speed and 8 proper recordings were made
      during this slow-speed walking. One whole step was considered complete from heel landing
      (initial contact) to toe-off. A force plate was used to determine the heel-strike and toe-off
      phase during walking. Corrections in the axes of the knee and ankle were made if necessary
      and tiles were saved for further data output.
    

Intervention name(s): ORIF
Intervention type(s): Procedure
Intervention description(s): surgery for foot and ankle fractures
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        healthy subjects and patients after foot and ankle trauma fracture surgery
Calcium, Dairy, and Body Fat in Adolescents
Condition: Obesity; Energy Metabolism
MeSH terms: Obesity
Study type: Interventional

Summary: 
      Lifestyle choices,including diet,are conducive to healthy body weights in children. Dairy
      products and calcium supplementation have been associated with moderation of body weight and
      body fat. This study was designed to test the following hypotheses with overweight and obese
      adolescents consuming a controlled diet:

        -  Dietary calcium supplementation as calcium carbonate or dairy calcium modulates energy
           balance in adolescents.

        -  Increased calcium in the diet of adolescents will increase fecal fat excretion and
           thereby decrease fat absorption.

        -  Calcium and dairy product supplementation will increase lipid oxidation resulting in an
           increase in energy expenditure.
    

Detailed description: 
      Subjects will consume a controlled diet containing 800 mg calcium for two three week periods.
      During one period they will also receive a frozen ice cream like product (smoothie) twice a
      day based on soy protein that contains no additional calcium. During the other period they
      will receive a similar product twice a day based on either dairy protein that contains 650 mg
      calcium or based on soy protein that contains 650 mg calcium as calcium carbonate
    

Intervention name(s): C (smoothies based on soy protein containing no additional calcium); B (smoothies based on soy protein containing calcium); A (smoothies based on dairy protein containing calcium)
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Two smoothies per day based on soy protein containing no additional calcium; Two smoothies daily based on soy protein containing 650 mg calcium as calcium carbonate; Two smoothies daily based on dairy protein containing 650 mg calcium
Intervention MeSH terms: Calcium, Dietary; Calcium
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Keywords: calcium carbonate; obesity; dairy; energy expenditure
Cohort Study of Endometriosis at Different Sites
Condition: Recruitment
MeSH terms: Endometriosis
Study type: Observational

Summary: 
      To present the clinical characteristics of pelvic or extra-pelvic endometriosis and explore
      the potential risk factors of pathogenesis and recurrence by comparing patients with
      endometriosis at different sites
    

Detailed description: 
      Endometriosis is a chronic inflammatory disease defined as the presence of endometrial glands
      and stroma outside of the internal epithelial lining of the cavum uteri, affecting up to 10%
      of reproductive age women. It is rarely found in extrapelvic locations.This form of
      endometriosis may be difficult to diagnosis due to pleomorphic presentation. Despite complete
      excision with a safe margin and histopathological examination has been considered as
      definitive diagnosis and primary therapeutic treatment for extra-pelvic endometriosis, what
      is understood mainly comes from case reports and retrospective observations with limited
      number of cases. Moreover, approximately 6%-14% of patients with PEM who had underwent
      narrowly operative resection still suffered recurrent lesions, while risk factors were barely
      identified.

      Patients with endometriosis at different sites in our hospital were collected for analysis of
      clinical characteristics namely demographic information, medical history, surgical records,
      pathological and imaging reports, serum levels of cancer antigen 125 (CA125), peri-operative
      medication. During long-term follow-up, prognosis of individuals could be identified by
      telephone or clinical interview. Based on data from medical records or clinical observation,
      risk model predicting recurrence will be established by comparing patients with different
      outcomes or exposed to different risk factors. Thus, management of endometriosis might be
      improved. Hopefully, pathogenesis of recurrent and primary endometriosis might be explained.
    

Intervention name(s): Surgical endometrioma excision
Intervention type(s): Procedure
Intervention description(s): We collect medical records of patients who had underwent surgical endometrioma excision at different sites in our hospital and conduct telephone or clinical interview
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Women aged between 18 years old to 50 years old, who were diagnosed as endometriosis (both
        pelvic and extra-pelvic) and received surgical treatment in PUMCH.
Factors Associated to Success of Hepatitis C Therapy
Condition: Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted
MeSH terms: Hepatitis A; Hepatitis C; Hepatitis
Study type: Observational

Summary: 
      The aim of this study is to evaluate the sustained virologic response (RVS) in HVC patients
      treated with pegylated-interferon or conventional-interferon and ribavirin, and to
      investigate the associated factors with RVS, by means of retrospective analysis.
    

Detailed description: 
      Chronic hepatitis C virus(HVC) is a major public-health problem since it presents a long
      phase of clinical latency which makes its early diagnosis difficult and results in the
      development of a large number of cases to complications such as cirrhosis, hepatic
      insufficiency and hepatocarcinoma. In Brazil, it is estimated three million estimated cases
      to 52 thousand reports. The aim of this study is to evaluate the sustained virologic response
      (RVS) in HVC patients treated with pegylated-interferon or conventional-interferon and
      ribavirin, and to investigate the associated factors with RVS, by means of retrospective
      analysis.
    

Intervention name(s): pegylated-interferon, conventional-interferon, ribavirin
Intervention type(s): Drug
Intervention description(s): Genotype 1: pegylated-interferon 2a or 2b plus ribavirin for 48 weeks. Genotype 3: conventional-interferon 2a or 2b plus ribavirin for 24 weeks.
Other intervention name(s): Pegasys; PegIntron; Ribavirin
Intervention MeSH terms: Interferons; Ribavirin
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        HVC patients attended in SAE e HD.
Bimanual Training in Children With Hemiplegia
Condition: Hemiplegia; Cerebral Palsy; Children
MeSH terms: Cerebral Palsy; Hemiplegia
Study type: Interventional

Summary: 
      A randomized control trial of bimanual training in children with hemiplegia. The protocols
      have been developed at Columbia University to be child friendly and draws upon our experience
      since 1997 with constraint-induced movement therapy in children with cerebral palsy. The
      investigators will test the hypothesis that bimanual training (HABIT) will result in improved
      hand function in children with hemiplegia.
    

Detailed description: 
      A new treatment involving bimanual (Hand-Arm Bimanual Intensive Therapy (HABIT). The
      protocols have been developed at Columbia University to be child friendly and draws upon our
      experience since 1997 with constraint-induced movement therapy in children with cerebral
      palsy. The investigators developed HABIT in 2004 as an alternative to constraint-therapy that
      avoids use of a restraint. The interventions are performed in a 15 day day-camp setting with
      several children and at least one therapist per child. The investigators have conducted 24
      day camps to date since 2002, and are now collaborating with clinicians worldwide to expand
      our treatment availability. The aim is to promote the use of and improve the coordination of
      movement of both hands together. PARTICIPATION IS FREE. Please check out our website for more
      information: http://www.tc.edu/centers/cit/
    

Intervention name(s): HABIT
Intervention type(s): Behavioral
Intervention description(s): 90 hours of bimanual training over 3 weeks in a day camp environment
Other intervention name(s): constraint-induced movement therapy, bimanual training, occupational therapy, physical therapy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: cerebral palsy; constraint-induced therapy; constraint-induced movement therapy; CP; hemiplegia; hand; forced use; motor control; children; HABIT; Hand-arm bimanual intensive therapy; bilateral training; bimanual training; functional therapy; physical therapy; occupational therapy; intensive; pediatric; development; upper extremity; hemiplegic; childhood stroke
Evaluation of the KLOX BioPhotonic WoundGel System in the Treatment of Surgical Wounds
Condition: Surgical Wounds
MeSH terms: Wounds and Injuries; Surgical Wound
Study type: Interventional

Summary: 
      This is a multicenter, randomized, prospective, controlled study in patients having bilateral
      breast reduction. Objectives of the study are to evaluate the safety and efficacy of the KLOX
      BioPhotonic WoundGel System compared with the ones of Silicone Sheets in the treatment of
      surgical wounds.
    


Intervention name(s): KLOX BioPhotonic WoundGel System; Silicone sheets
Intervention type(s): Device; Device
Intervention description(s): Patients will then be re-randomized to one of the three comparisons: treatment starting on day 7 post-surgery, treatment starting on Day 21 post-surgery, or two consecutive treatments applied once weekly.; Treatment of the surgical wounds with silicone sheets.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Study to Evaluate GSK2190915 in Subjects With Mild Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 2

Summary: 
      This study will evaluate the safety and effect of repeat oral doses of GSK2190915 on lung
      function in mild asthmatics using a number of clinical and biological markers of efficacy.
    


Intervention name(s): GSK2190915
Intervention type(s): Drug
Intervention description(s): Investigational Product
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: GSK2190915; Repeat; Oral; Dose; Challenge; Asthma; Allergen
Study of a Cohort of Cases of Synovial Sarcoma Treated in the Orthopedic Surgery and Traumatology Department of the Hospital de Sant Pau Between 1983 and 2016
Condition: Soft Tissue Sarcoma Adult
MeSH terms: Sarcoma; Sarcoma, Synovial
Study type: Observational [Patient Registry]

Summary: 
      The main objectives of this study are the following: to describe the prognostic factors of
      survival of synovial sarcoma in patients treated by the orthopedic surgery unit oncologic of
      the orthopedic surgery and traumatology service of the Hospital de Sant Pau during the years
      1983-2016.
    

Detailed description: 
      Another objectives of this Study are:

      To analyze exhaustively a series of cases of synovial sarcoma (as an example of classic
      subtype of soft tissue sarcoma) to analyse the complementary tests performed and their
      evolution over time.

      To analyse the results of surgical treatment and adjuvant therapies in synovial sarcoma and
      its evolution over time.

      To study the prognostic factors dependent on the patient and the applied therapeutics.

      To establish a results-based treatment and follow-up algorithm for patients diagnosed with
      synovial sarcoma.

      To describe the epidemiological characteristics of the group of patients in the study.

      To evaluate the overall survival and disease-free survival as well as the mortality of the
      disease.

      To assess the rate of local recurrence and remote dissemination of synovial sarcomas in the
      series.

      To demonstrate the influence of neoadjuvant chemotherapy and radiotherapy in the treatment of
      the tumor.

      Conduct a study by age group with respect to the influence on patient survival. To carry out
      a study by tumor-sized groups with respect to the influence on the survival of the patients.

      To carry out a chronological study on the influence of the advances in the treatments on the
      survival of the patients.

      Compare the results obtained with the published literature.
    

Intervention name(s): Soft tissue sarcomas in adults
Intervention type(s): Other
Intervention description(s): Adult sinovial sarcoma
Observational model: Cohort
Time perspective: Other
Sampling method: Probability Sample
Study population: 
        The overall sample size will be 90 cases of synovial sarcoma diagnosed and treated by the
        unit, considering a sufficient number of cases in the analysis with sufficient potency to
        respond to the issues raised methodology. Sources of information all clinical records of
        the patients will be reviewed and a total of 104 elements collected, collecting data in
        relation to the epidemiology, personal and family history, physical examination,
        complementary tests of Local and extension diagnosis, time to diagnosis and treatment,
        pathological diagnosis, surgical technique, adjuvant therapy, complications of treatment,
        staging, clinical evolution, recurrences and metastases, functional valuation and data of
        survival and follow-up.
      
Keywords: Synovial sarcoma
Reconstruction of Upper Eyelid With a Newly Modified Cutler-Beard Technique With Tarsoconjunctival Graf
Condition: Reconstructive Surgical Procedure
Study type: Interventional

Summary: 
      To study the results of a modified Cutler-Beard technique , using a contralateral
      tarsoconjunctival graft, in patients who underwent excision of large malignant tumors of the
      upper eyelid
    

Detailed description: 
      A tarsoconjunctival graft was harvested from the contralateral upper eyelid, with an extra 3
      mm of conjunctiva from the superior edge of tarsus and was attached to the upper eyelid
      defect, differently than previously described.

      Functional, cosmetic outcomes and postoperative complications were evaluated.
    

Intervention name(s): 'Cutler-Beard modified with graft'
Intervention type(s): Procedure
Intervention description(s): A tarsoconjunctival graft was harvested from the contralateral upper eyelid, with an extra 3 mm of conjunctiva from the superior edge of tarsus and was attached to the upper eyelid defect, differently than previously described.
Other intervention name(s): Modified Cutler-Beard technique with tarsoconjunctival graft
Intervention model: Single Group Assignment
Intervention model description: Retrospective review of charts of the patients enrolled
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Cutler-Beard; tarsoconjunctival graft; upper eyelid
Study of Vitamin D in the Severely Mentally Ill
Condition: Schizophrenia; Schizoaffective Disorder
MeSH terms: Schizophrenia; Psychotic Disorders
Study type: Interventional
Phase: Phase 4

Summary: 
      Supplementation of Vitamin D in those with low levels will increase the level and result in
      some improvement in health and psychopathology measures.
    

Detailed description: 
      Subjects with levels of Vitamin D between 7ng/ml and 30ng/ml will, after signing consent
      forms, be randomly assigned to either start immediately on Vitamin D for three months or to
      start after a delay of three months. Those with levels below 7gn/ml will start immediately.
      All will be evaluated monthly with blood tests, PANSS, movement disorder ratings and
      information on health and progress from the clinical chart.
    

Intervention name(s): Vitamin D3; Vitamin D3
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 50,000 units of Vitamin D3 weekly; Vitamin D3 50,000 units weekly
Other intervention name(s): Cholecalciferol; Cholecalciferol
Intervention MeSH terms: Vitamin D; Ergocalciferols; Cholecalciferol; Vitamins
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Vitamin D; Schizophrenia; Severely Mentally Ill
Progesterone Supplementation in Threatened Abortion
Condition: Threatened Abortion; Progesterone Resistance
MeSH terms: Abortion, Threatened
Study type: Interventional
Phase: Phase 4

Summary: 
      To decide whether progesterone supplementation in threatened abortion is a sound practice.
    

Detailed description: 
      This study was conducted at Obstetrics and Gynecology Department, Tanta University in the
      period from January 2018 to December 2018. Patients: Eligible patients (n=190) were randomly
      allocated into 2 groups; study group who will receive progesterone supplementation
      (Prog.group) and control group who will receive no treatment (place.group).
    

Intervention name(s): Progesterone; Placebos
Intervention type(s): Drug; Drug
Intervention description(s): received rectal progesterone suppositories 400 mg once daily; received placebo suppositories rectally once daily.
Intervention MeSH terms: Progesterone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment