bioihbjkbjnl/mcl2 huggingface dataset:
Vit D Receptor Gene Polymorphism
Condition: Vitamin D Status
MeSH terms: Dental Caries
Study type: Observational

Summary: 
      The present cross-sectional observational study was conducted after the university ethical
      committee approved the research (NU/CEC/2020/0339). This study included 376 adults in the age
      group of 18-40Yrs. The patient information sheet briefed the study details and usage of
      salivary samples. Informed consent was obtained from participants. Healthy individuals free
      of associated systemic conditions, individuals not under any nutritional supplementation were
      included in the study, and lactating mothers, smokers, and menopausal women were excluded
    

Detailed description: 
      The present cross-sectional observational study was conducted after the university ethical
      committee approved the research (NU/CEC/2020/0339). This study included 376 adults in the age
      group of 18-40Yrs. The patient information sheet briefed the study details and usage of
      salivary samples. Informed consent was obtained from participants. Healthy individuals free
      of associated systemic conditions, individuals not under any nutritional supplementation were
      included in the study, and lactating mothers, smokers, and menopausal women were excluded.

      Further, the subjects were divided into active and caries-free based on caries experience.
      Two indexing methods were utilized to record the decay status, i.e., Decay, Missing, filled
      (DMFT) and Pulpal, Ulcerative, Fistula (PUFA) scores. Caries active group was further divided
      into a High-risk group (DMFT=< 10), Moderate risk (DMFT= 4-9), and Low risk (DMFT=1-3).

      Questionnaire: Baseline information was gathered, including specifics on age, sex, height,
      weight, dietary preferences (non-veg/veg), and dental hygiene practices.
    

Intervention name(s): questionnaire
Intervention type(s): Other
Intervention description(s): questionnaire
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The study population included participants with active dental caries and associated wasting
        disease of the teeth due to caries
      
Keywords: Vitamin D Gene Polymorphism; Dental Caries; Cathelicidins
To Determine if a Lower Extremity Strengthening Program Improve Quadriceps Muscle Strength
Condition: Pulmonary Disease
MeSH terms: Lung Diseases
Study type: Interventional

Summary: 
      The purpose of this study is to determine if a lower extremity strengthening program as part
      of pulmonary rehabilitation will improve quadriceps muscle strength, endurance and functional
      status as well as overall quality of life.

      Hypothesis:

        1. Lower extremity resistance training as part of a pulmonary rehabilitation program will
           improve quadriceps strength, endurance and functional capacity.

        2. Lower extremity resistance training as part of a pulmonary rehabilitation program will
           improve quality of life in patients awaiting lung transplant.
    

Detailed description: 
      Objectives:

        1. To determine if a lower extremity strengthening program as part of pulmonary
           rehabilitation is effective at increasing quadriceps strength when measured with a hand
           held dynamometer.

        2. To determine the effectiveness of a lower extremity strengthening program as part of
           pulmonary rehabilitation for improving endurance and functional capacity as measured by
           the six minute walk test.

        3. To determine if the lower extremity strengthening program as part of pulmonary
           rehabilitation improves overall quality of life as measured by the St. George's
           Respiratory Questionnaire.

        4. To provide a basic framework for a larger randomized control study evaluating if a lower
           extremity strengthening program as part of a pulmonary rehabilitation program is more
           effective than a pulmonary rehabilitation program alone at improving quadriceps
           strength, endurance, and functional level.
    

Intervention name(s): Exercise
Intervention type(s): Other
Intervention description(s): Lower extremity resistance exercises and aerobic exercises 3 times a week in 10 week pulmonary rehabilitation program prior to lung transplant.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Lung Transplant; Quadriceps Strength; Quality of Life; Patients with pulmonary disease awaiting lung transplant.
Study of the Effectiveness and Safety of Desloratadine (Aerius) Syrup in Children With Hayfever With or Without Asthma (P03472)
Condition: Rhinitis, Allergic, Seasonal; Asthma
MeSH terms: Rhinitis; Asthma; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study was to test the effectiveness and safety of desloratadine (Aerius)
      syrup in children with hayfever with or without asthma. Patients took desloratadine syrup
      once a day for 28 days. Once a week, the doctor measured the patient's hayfever symptoms. The
      doctor also rated how much relief the patient got from treatment and recorded any side
      effects.
    


Intervention name(s): Desloratadine
Intervention type(s): Drug
Intervention description(s): desloratadine syrup; 5.0 mL once daily for 28 days
Other intervention name(s): Clarinex; Aerius; SCH 34117; descarboethoxyloratadine
Intervention MeSH terms: Desloratadine
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effects of Contact Lens Wear on Children's Self-Perceptions
Condition: Myopia
MeSH terms: Myopia
Study type: Interventional

Summary: 
      The purpose of the study is to determine whether contact lens wear will improve children's
      self-perceptions more than spectacle wear.
    

Detailed description: 
      Eight to eleven year old children will be randomly assigned to wear spectacles or soft
      contact lenses. The children's self-perceptions will be measured at baseline and every six
      months. We will compare the change in self-perception between spectacle and soft contact lens
      wearers over three years. We will also examine the effect of how much children initially like
      or dislike to wear glasses on the change in self-perception over three years.
    

Intervention name(s): Soft contact lenses; Spectacle
Intervention type(s): Device; Device
Intervention description(s): Daily wear soft contact lenses disposed of daily or biweekly; Spectacles for the treatment of myopia
Other intervention name(s): 1 Day Acuvue or Acuvue 2 contact lenses; Children chose their own frames.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Keywords: Myopia; Self-Perception; Contact Lenses; Glasses; Randomized; Children; Self-esteem
PLANNED VISUAL EDUCATION ABOUT SKIN CANCER
Condition: Skin Neoplasm
MeSH terms: Skin Neoplasms
Study type: Interventional

Summary: 
      This study aimed to evaluate the effect of planned visual education based on the Health
      Belief Model on university students' attitudes and beliefs toward skin cancer. The planned
      visual education based in Health Belief Model has possitive effects on univestiy students'
      attitudes and beliefs toward skin cancer.
    

Detailed description: 
      This study aimed to evaluate the effect of planned visual education based on the Health
      Belief Model on university students' attitudes and beliefs toward skin cancer. Planned as a
      cluster-randomized controlled experimental study conducted on two groups (n=116). The study
      was carried out in Faculty of Economics and Administrative Sciences (FEAS) and Hasan Ferdi
      Turgutlu Faculty of Technology (HFTFT) from the faculties of Manisa Celal Bayar University
      (MCBU) between February-Semptember 2019. Among seven departments in FEAS and four departments
      in the HFTFT, simple random sampling was used to draw lots again. The Department of
      Econometrics from the FEAS was assigned as the intervation groups (n=58) and Mechatronics
      Engineering from HFTFT was assigned as the control group (n=58). Data were collected using
      The Student Introduction Form and The Health Belief Model Scale in Skin Cancer.
    

Intervention name(s): Planned Visual Education Based on Health Belief Model
Intervention type(s): Other
Intervention description(s): The students in IG were administered the planned visual education based on Health Belief Model for a period of seven months.
The education materials were a PowerPoint presentation, a skin cancer model, videos titled "Dear 16 years old me", "Mr. Sun", a brochure, and 3 posters.
.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The sample of this cluster randomized controlled experimental study consisted of 2nd year university students (n=116) training in Faculty of Economics and Administrative Sciences (FEAS) and Hasan Ferdi Turgutlu Faculty of Technology (HFTFT) from the faculties of Manisa Celal Bayar University (MCBU) between February-Semptember 2019. Among the faculties in MCBU, simple random sampling was used to draw lots, with the first lot being assigned to FEAS as the intervention group (IG), and the second lot being assigned to HFTFT as the control group (CG) . Among seven departments in FEAS and four departments in the HFTFT, simple random sampling was used to draw lots again. The Department of Econometrics from the FEAS was assigned as the IG and Mechatronics Engineering from HFTFT was assigned as the CG.
58 students for the CG and 58 students for the IG were recruited for the sample. Power of the study was calculated as post hoc at α=0.05 with a significance of 0.95.
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Health belief model; health attitudes; university students; skin cancer
Unblinded Data Collection Study of Concussion Using BrainPulse
Condition: Concussion, Intermediate
MeSH terms: Brain Concussion
Study type: Observational

Summary: 
      This is a prospective, non-blinded, matched control study of young athletes (ages 10-28 years
      old) in collegiate sports. The cohorts are defined in accordance to the athlete's exposure of
      injury. All subjects will complete a minimum of one recording based on their assigned cohort.
      Concussed athletes will complete an additional 3 weeks of follow-up recordings post injury.
      The symptomatic evaluation, physical examination, neurological baseline testing, and
      BrainPulse recordings will be entered in a database to determine clinical outcome and assess
      device utilization.
    

Detailed description: 
      Cohort I is defined as all enrolled athletes at the University of Wyoming and is divided into
      two sub-cohorts: Cohort Ia include all athletes participating in Division 1 Athletics; Cohort
      Ib are athletes subscribed to the Head Health Network. Cohort II is defined as all injured
      athletes participating in the teams and includes two sub-cohorts: Cohort IIa is defined as
      non- concussed injured athletes; Cohort IIb concussed athletes per reference standard.
    

Intervention name(s): BrainPulse
Intervention type(s): Device
Intervention description(s): JanMedical's BrainPulse measures the brain motion caused by pulsatile blood flow from the cardiac cycle referred to as the BrainPulse signal. The BrainPulse measures skull acceleration in response to tge brain motion using an array of sensors placed on the head.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Athletes participating in Division 1 Athletics at the University of Wyoming
Virtual Rehabilitation and Conventional Therapeutic Exercises in the Treatment of Individuals Post Stroke
Condition: Stroke; Cerebrovascular Disorders
MeSH terms: Stroke; Cerebrovascular Disorders
Study type: Interventional

Summary: 
      The purpose of this study is to determine the effects of the use the Nintendo Wii® (NW) and
      conventional therapeutic exercises in the rehabilitation of balance and gait of the
      post-stroke patients and the impact on quality of life.
    

Detailed description: 
      This Randomised clinical trial (RCT) has longitudinal and prospective feature, held at the
      Neurosciences Clinic located at the Clinic Professor Francisco Magalhães Neto the HUPES
      Complex / Federal University of Bahia from June 2015 until June 2017.

      In the initial evaluation were obtained by a trained examiner and blinded to the allocation
      of participants, all personal data of all patients, as well as evaluations of balance, gait,
      and quality of life through specific validated scales:

        1. Berg Balance Scale (BBS);

        2. Tinetti Gait Scale (TGS)

        3. Quality of Life Scale Specific for stroke (QLSSS) ;

      The investigators employ a program of conventional therapeutic exercises and virtual
      rehabilitation with NW, for a period of two months, with sessions two times a week for 50
      minutes (a total of 16 sessions).
    

Intervention name(s): Virtual Rehabilitation; Conventional therapeutic exercises; Virtual Rehabilitation and Conventional Therapeutic Exercise
Intervention type(s): Other; Other; Other
Intervention description(s): It is the use of the NW games for rehabilitation of balance and gaite in post-stroke patients.; It is the use of the conventional therapeutic exercises for rehabilitation of balance and gait in post-stroke patients.; It is the use of the conventional exercises and of the NW for rehabilitation of balance and gait in post-stroke patients.
Other intervention name(s): NW; Non-immersive virtual reality; Commercial Game; Wii-rehabilitation; Conventional physical therapy; Conventional exercises to improve balance and gait; Diagonals of PNF; PNF method; Non-immersive virtual reality; Wii-rehabilitation; Commercial Game; Conventional exercises to improve balance and gait; Diagonals of PNF
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Stroke; Hemiparesis; Physical Therapy; Virtual Reality Exposure Therapy; Video Games
Tolerability and Pharmacokinetics of Hypidone Hydrochloride in Healthy Subjects
Condition: Major Depressive Disorder
MeSH terms: Depressive Disorder; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will investigate the tolerability and pharmacokinetics of Hypidone Hydrochloride
      by multiple doses in 36 healthy male and female subjects who are of 18 to 55 years old.
    

Detailed description: 
      This is a double-blind, placebo-controlled, randomized, multiple-dose, single center study.
      36 male and female healthy subjects will be enrolled in this study. Within 14 days prior to
      study drug administration, subjects will be screened based on the inclusion and exclusion
      criteria. The study will be performed in 3 groups of 12 subjects each. In each group of 12
      subjects, 10 subjects will be randomly assigned to receive Hypidone Hydrochloride and 2
      subjects to receive matching placebo.
    

Intervention name(s): Hypidone Hydrochloride tablets; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 30mg(10mg×3), 40mg(10mg×4) or 50mg(10mg×5) Hypidone Hydrochloride tablets will be given orally once on day 1, day 9 and twice a day on day 3~8.; 3, 4 or 5 tablets of placebo will be given orally once on day 1, day 9 and twice a day on day 3~8.
Other intervention name(s): HHT101
Allocation: Randomized
Intervention model: Sequential Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Addressing Help-Seeking Barriers in Developing an Intensive Treatment for Veterans With Panic Disorder
Condition: Panic Disorder
MeSH terms: Panic Disorder
Study type: Interventional

Summary: 
      The purpose of this study is to understand some of the reasons why recently deployed veterans
      decline psychosocial treatment options for panic disorder and to test a brief weekend
      treatment for panic attacks.
    

Detailed description: 
      The population of interest for this program includes men and women returning from deployment
      in Iraq or Afghanistan who are seen in the TRP at the MEDVAMC. The study consists of two
      parts: PART 1 involves a qualitative investigation of treatment-seeking barriers specific to
      persons who refuse standard treatments and PART 2 is a pilot intervention to treat panic
      symptoms in service members who have co-existing PTSD symptoms. PART 1 will include
      approximately 15 individuals who will be interviewed by a member of the study staff. Patients
      will be interviewed individually following a semi-structured questionnaire designed to help
      identify treatment-seeking barriers. PART 2 will include 8 individuals who will be enrolled
      in an open-trial of a two-day intensive cognitive-behavioral treatment for panic disorder,
      which will occur over the weekend. No participants will be assigned to a control condition.
      All activities related to this project including the interviews and intervention will be
      delivered in either the TRP at the MEDVAMC or at the Houston Center for Quality of Care and
      Utilization Studies (HCQCUS), a nearby facility.
    

Intervention name(s): CBT
Intervention type(s): Behavioral
Intervention description(s): cognitive- behavioral treatment for panic disorder.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
TMS for Suicidal Crisis in Active Duty SMs
Condition: Suicide; Suicidal Ideation; Suicidal Impulses; Suicidal Intention; Suicidal and Self-Injurious Behavior; Suicidal Depression
MeSH terms: Suicide; Suicidal Ideation; Self-Injurious Behavior
Study type: Interventional

Summary: 
      The purpose of this study is to determine if the use of Transcranial Magnetic Stimulation
      (TMS) provides rapid reduction and sustained attenuation of suicidal crisis. TMS is a
      treatment for suicidal crisis that is quicker, less invasive, better tolerated, and with
      fewer side effects than current treatments such as Electroconvulsive Therapy (ECT) and
      medication therapies. There will be 6 months of follow-up, in order to establish the ongoing
      and lasting therapeutic effect of TMS.
    

Detailed description: 
      The programmatic-level objective of the study is to address the goals of the Army STARRS
      Program and the Suicide Prevention for America's Veterans Act through implementation of an
      effective acute treatment for patients psychiatrically admitted in suicidal crisis as well as
      other patients at high-risk for suicide. This is achieved by application of TMS, which
      provides a treatment for suicidal crisis that is quicker, less invasive, better tolerated,
      and with fewer side effects and less incapacitation than current treatments such as ECT and
      pharmacologic therapies. A recent study led by the senior consultant of this proposal
      demonstrated tolerance and efficacy for a new, high-dose regimen of TMS in a VA population
      with an average age of 47. The objective of the proposed study is to extend the application
      of TMS to a younger population of Active Duty Service Members (SM) in order to demonstrate
      efficacy for returning veterans of the Middle East wars, in particular, as well as the
      civilian young adult population. TMS dosage in the proposed study is recalibrated to
      commercially-standard levels in order to provide consistency with devices currently in
      clinical operation. In addition, follow-up in the proposed study continues for 6 months in
      order to establish persistence and durability of the therapeutic effect of TMS.
    

Intervention name(s): Neuronetics NeuroStar XPLOR magnetic stimulator - Active; Neuronetics NeuroStar XPLOR magnetic stimulator - Sham
Intervention type(s): Device; Device
Intervention description(s): Localization: Left prefrontal dorsolateral neocortex. Dose Delivery: Figure-8 solid core coil at 120% motor threshold, 10 Hz, 4 second train duration, 10 second interval for 30 minutes.
Treatment Dose: ~4k/session, 12-15k/day, 36-45k total pulses. Sessions: 9 in total; 3/day for 3 consecutive days over and above SOC.; Localization: Left prefrontal dorsolateral neocortex. Sham Delivery: Figure-8 solid core coil rendered inert via blocking insert. Dose: Zero pulses. Sessions: 9 in total; 3/day for 3 consecutive days over and above SOC.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
The Effects of Adding TCM-700C on the Standard Combination Treatment for Patients With Genotype 1 Hepatitis C Infection
Condition: Chronic Hepatitis C
MeSH terms: Hepatitis A; Hepatitis C; Hepatitis C, Chronic; Hepatitis
Study type: Interventional
Phase: Phase 2

Summary: 
      The primary objective of this study is to evaluate the effectiveness of TCM-700C as an add-on
      treatment to the combination drug therapy (Peginterferon α-2b plus Ribavirin) for patients
      with genotype 1 chronic hepatitis C infections. This will be demonstrated by a higher
      sustained virologic response rate, defined as the absence of detectable HCV RNA 24 weeks
      after the termination of combinational drug treatment, compared with the placebo add-on.
    

Detailed description: 
      This was a randomized, double-blind, placebo controlled, parallel-group, Phase 2 study to
      evaluate the effects of adding a Chinese formulation (TCM-700C) on the standard combination
      treatment for patients with Genotype 1 hepatitis C infection. Patients were screened within 4
      weeks before receive the first study drug dose. Eligible patients at baseline were stratified
      according to baseline HCV RNA (≤800,000 IU/ml vs >800,000 IU/ml) and randomized with an equal
      chance to receive either TCM-700C or placebo as an add-on to the combination drug therapy.
      The combination drug therapy was peginterferon α-2b (PEG-INTRON®, Schering-Plough) 1.5
      micrograms/kg once weekly injection for 48 weeks plus oral ribavirin (REBETOL®,
      Shering-Plough) 1000mg-1200mg daily for 48 weeks. The add-on treatment of TCM-700C or placebo
      was given 2 tablets thrice daily for 48 weeks.

      During the 48 week treatment period and 24 week untreated follow-up, patients were assessed
      at regular intervals for safety and efficacy at weeks 2, 4, 8, 12, 16 and then every 8 weeks
      thereafter until study completion. Patients who prematurely discontinued test drug therapy
      had laboratory examination re-taken on the week patient was discontinued from study.
    

Intervention name(s): TCM-700C; Peginterferon alfa-2a; Ribavirin; Placebo
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): An add-on drug to conventional treatment of Hepatitis C; conventional treatment of Hepatitis C; conventional treatment of Hepatitis C; Placebo, without acting ingredient.
Other intervention name(s): Peg-INTRON, Schering-Plough; Rebetol, Schering-Plough)
Intervention MeSH terms: Ribavirin; Peginterferon alfa-2a; Peginterferon alfa-2b
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: add-on treatment; botanical drug; HCV genotype 1; TCM-700C; genotype I