bioihbjkbjnl/mcl2 huggingface dataset:
Prednisone for Heart Failure Patients With Hyperuricemia
Condition: Heart Failure; Hyperuricemia
MeSH terms: Heart Failure; Hyperuricemia
Study type: Interventional
Phase: Phase 4

Summary: 
      Hyperuricemia is a very common finding in patients with heart failure. It is usually related
      to diuretic use and deteriorated renal function. The recently evidence showed that uric acid
      (UA) lowering therapy may improve clinical status in symptomatic heart failure patients with
      hyperuricemia. In their clinical practice, the investigators found that glucocorticoids could
      dramatically lower UA while improving renal function. Thus the investigators design this
      randomized head to head study to test our hypothesis that prednisone have the same efficacy
      to allopurinol on lowering UA and could improve renal function at the same time.
    


Intervention name(s): prednisone; allopurinol
Intervention type(s): Drug; Drug
Intervention description(s): 1 mg/kg/day with a maximum dose of 60 mg/day given orally; allopurinol, the dose of allopurinol is adjusted by patients' renal function, and with a maximum dose of 300mg/day.
Intervention MeSH terms: Prednisone; Allopurinol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: prednisone; allopurinol; heart failure; hyperuricemia
Radiofrquency Ablation Combined With Cytokine-induced Killer Cells for Colorectal Cancer Liver Metastases
Condition: Colorectal Cancer
MeSH terms: Colorectal Neoplasms; Neoplasm Metastasis
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      The purpose of this study is to determine whether combining of radiofrequency ablation (RFA)
      and cytokine-induced killer cells (CIK) transfusion can prolong survival of patients with
      colorectal cancer liver metastases (CRCLM).
    

Detailed description: 
      The primary objective is to evaluate whether RFA followed by CIK transfusion can prolong
      survival of patients with resectable CRCLM.
    

Intervention name(s): Radiofrequency ablation; Cytokine-induced killer cells
Intervention type(s): Procedure; Biological
Intervention description(s): Radiofrequency ablation is performed percutaneously under CT/US guidance.; The patients received autologous cytokine-induced killer cells transfusion one week after RFA treatment.
Other intervention name(s): RFA; CIK
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: radiofrequency ablation; cytokine-induced killer cells; colorectal cancer iver metastases
Growth Hormone in Children Under 2 Years With Prader-Willi in Hospital of Sabadell
Condition: Prader-Willi Syndrome
MeSH terms: Prader-Willi Syndrome; Syndrome
Study type: Observational

Summary: 
      The PWS is a genetic disease with intellectual disabilities associated with multiple
      manifestations in other body systems. It is characterized by hypothalamic-pituitary
      abnormalities with severe hypotonia during the early years of life, conditioning feeding
      difficulties. Hyperphagia appears later, causing severe obesity in pre - school ages. Other
      endocrine abnormalities associated produce short stature, GH deficiency and hypogonadotropic
      hypogonadism. These patients also have varying cognitive dysfunction associated as well as
      learning problems, compounded by the development of psychological-psychiatric and behavioral
      problems language. The aetiology of GH decreased secretion of the SPW is controversial, it is
      known that IGF -1 levels are reduced in children and adults with PWS. The rational use of GH
      is derived from knowledge of comorbidities observed in PWS, which seem to be related to GH
      deficiency: hypotonia, altered body composition, decreased growth, even obesity.

      • The GH is accepted since 2000 for the treatment of PWS. Following fatal episodes in our
      country, it was decided to start treatment at 2 years of age in an arbitrary manner, but not
      in the U.S. or France. Subsequent studies have found that GH per se is not a risk factor for
      mortality. The currently published data supporting the benefits of GH treatment when started
      between 4 and 6 months of life, even some experts advocate starting at 3 months, but due to
      the lack of consensus on the age of onset treatment, despite the benefits of your home at an
      early age before the onset of obesity often starts around 2 years of life.

      HYPOTHESIS The use of GH is safe and effective in patients with PWS children under 2 years
      old.
    


Intervention name(s): Recombinant Somatropin
Intervention type(s): Drug
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Hospitalary population
      
Keywords: Prader-Willi Syndrome; Growth Hormone; Children
Efficacy of Electroacupuncture on Acute Abdomen Emergency Care
Condition: Acupuncture
MeSH terms: Emergencies; Abdomen, Acute
Study type: Interventional

Summary: 
      Contrast to conventional Western medicine, traditional Chinese medicine is the most common
      used therapy of complementary and alternative medicine. Taiwan inherits traditional Chinese
      culture, and the people popularly accept traditional Chinese medicine for general diseases.
      However, most patients with acute or critical illness are used to admit to emergency
      department for medical services, and then transfer to the department of related specialist
      for further treatment. During the course of staying at emergent observation room, some
      diseases do not meet the criteria of admission and keep for evaluation. The longer of staying
      at emergent observation room the more waste medical resources.

      The Chinese medicine department of Changhua Christian hospital has treated patients, who
      consulted us at their own dispense, with subjective discomfort but remained at the emergent
      observation room. Detailed contents of this study include the Chinese and Western medicine,
      pharmaceutical, nursing cooperation mode, monitoring clinical effect of treating of the
      patients diagnosed with intestinal obstruction or ileus who complain about nausea, vomiting,
      abdominal pain, abdominal distension or constipation.And the patients were assigned to the
      control and treatment group. Then we give the treatment group with the electroacupuncture
      treatment,and the control groupe with the Chinese medicine seeds and the transcutaneous nerve
      stimulation (no power).The patients were diagnosed with objective analysis of tongue
      diagnosis, pulse diagnosis, heart rate variability, and questionnaire of pain. Hope that we
      can assess the efficacy of both two different treatment,and also assess the cost of medical
      care, and try to complete the syndromes statistical analysis of traditional Chinese medicine
      for abdominal pain, building the relevance of Chinese medicine physical assessment teaching
      and clinical efficacy.

      The most important of this clinical teaching is that, this is a good opportunity for Chinese
      medicine and Western medicine to cooperate with each other at the emergency department to
      confirm the efficacy of traditional Chinese medicine, not only in the field of chronic or
      geriatric diseases, but also in the field of emergency with the evidence base. This factually
      achieves communication and integration of Chinese and Western medicine, and benefits the
      public.
    


Intervention name(s): electroacupuncture
Intervention type(s): Other
Intervention description(s): acupuncture needle with TENS device
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: traditional Chinese medicine; electroacupuncture; abdominal pain
Immediate Decrease of Muscle Biomechanical Stiffness Following Dry Needling in Asymptomatic Participants
Condition: Healthy
Study type: Interventional

Summary: 
      60 healthy participants were randomized into infraspinatus, erector spinae, or gastrocnemius
      groups. One session of dry needling DN was applied to the muscle in standardized location.
      Stiffness was assessed using a MyotonPRO at baseline, immediately post DN, and 24 hours
      later. The presence of a localized twitch response (LTR) during DN was used to subgroup
      participants.
    


Intervention name(s): dry needling
Intervention type(s): Other
Intervention description(s): Physical therapy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of Infant Formula on Energy Balance
Condition: Development
Study type: Interventional

Summary: 
      The overarching goal of the research we propose here is to conduct a randomized clinical
      trial to specify the physiologic and behavioral mechanisms by which infant-formula
      composition affects all aspects of energy balance and growth during the first years of life.
    

Detailed description: 
      This is a randomized clinical trial of infants whose parents decided to formula feed them;
      mother-infant dyads will be randomized when infant is 2 weeks of age to one of 2 groups. The
      groups will differ in the composition of the formula fed to the infant during the first year
      of life.
    

Intervention name(s): Type of Formula
Intervention type(s): Other
Intervention description(s): infant formula
Other intervention name(s): cow milk formula (CMF); protein hydrolysate formula (EHF)
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Between- and within-subject longitudinal trial
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Other
Keywords: Formula Feeding; Mother; Moms; Infants; Babies; Baby; growth; energy balance
Allogeneic Mesenchymal Human Stem Cells Infusion Therapy for Endothelial DySfunctiOn in Diabetic Subjects
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This is a 16 subject trial to demonstrate the safety of allogeneic hMSCs administered via
      infusion therapy for diabetic subjects with endothelial dysfunction.
    


Intervention name(s): 20 million Allogeneic Mesenchymal Human Stem Cells; 100 million Allogeneic Mesenchymal Human Stem Cells
Intervention type(s): Drug; Drug
Intervention description(s): 1 single intravenous infusion; 1 single intravenous infusion
Other intervention name(s): allo-hMSCs; stem cells; allo-hMSCs; stem cells
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Diabetes; Endothelial dysfunction; Stem cells
Games & Well-Being Study
Condition: Attentional Processing; Adolescent Behavior
Study type: Interventional

Summary: 
      This project is focused on the neural and behavioral correlates of two different videos games
      that will be used as training tools. The two video games, developed by the Games Learning
      Society research group at the University of Wisconsin-Madison (UW) and the Wisconsin
      Institute for Discovery, are tailored to train mindfulness, particularly the regulation of
      attention; and prosocial behavior, especially sensitivity to others, in adolescents. This
      study will evaluate the hypothesis that systematic playing of mindfulness and prosocial games
      will change brain function in specific attentional, social and emotional circuits in
      potentially beneficial ways, and will impact performance on cognitive tasks of attention, and
      on measures of social cue perception and the propensity to share and behave altruistically.
      The investigators will employ behavioral and functional MRI-based neuroimaging measures to
      evaluate the investigators hypothesis.
    


Intervention name(s): Attention Training Intervention Game; Prosocial Training Intervention Game; Control for Attention Intervention; Control for Prosocial Intervention
Intervention type(s): Other; Other; Other; Other
Other intervention name(s): Tenacity; Crystals of Kaydor
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Keywords: prosocial behavior; prosocial; attention training; attention; empathy; emotion recognition
Evaluation of Apathy Using Attentional Reaction Test in Neurodegenerative Diseases
Condition: Alzheimer Disease
MeSH terms: Alzheimer Disease; Neurodegenerative Diseases
Study type: Interventional

Summary: 
      Apathy, defined as a lack of motivation in behaviour, cognition and affect, is common in
      neurodegenerative diseases. Specific scales are available for the evaluation of apathy but it
      lacks objective evaluation methods.

      The aim of this study is to evaluate the changes in reaction time task according to the
      presence or absence of reward stimulation and to assess the relation between these
      performances and apathy scales.
    

Detailed description: 
      MATERIAL: 13 patients with Mild Cognitive Impairment (MCI), 15 patients with Alzheimer's
      disease (AD) and 91 elderly healthy subjects were enrolled. A computerized test using the
      experiment software E-prime® was designed to assess reaction times (in ms) in different
      experimental conditions after a training trial (neutral, stimulation, stress, stimulation
      after stress, extinction) and relation between the performances to the test and the Apathy
      Inventory (AI) scores (lack of initiative, lack of interest, emotional blunting) were
      observed.

      METHOD: Using a computerized test, each patient is asked to press a button (mouse of the
      computer) each time the screen of the computer becomes completely white. After pressing the
      button, a randomized colorized geometric figure appears on the screen, and disappears
      automatically after a few seconds, replaced by a new white screen. Reaction time (in ms)
      between a white screen and a press of the button is analysed. After a training trial,
      reaction times are analysed in different experimental conditions: neutral - stimulation1
      (patient gets points when pressing the button) - stress (alarm) - stimulation2 (patient gets
      points when pressing, after the stress trial) - extinction (similar to neutral condition).
    

Intervention name(s): computerized test
Intervention type(s): Behavioral
Intervention description(s): Using a computerized test, each patient is asked to press a button (mouse of the computer) each time the screen of the computer becomes completely white.
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Anti-aging and Anti-oxidant Efficacy Evaluation of the MelaGene
Condition: Aging; Antioxidative Stress
Study type: Interventional

Summary: 
      The primary purpose of the present study is to evaluate the effects of MelaGene on anti-aging
      and anti-oxidant.
    


Intervention name(s): Placebo drink; MelaGene drink
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): consume 1 bottle per day for 8 weeks; consume 1 bottle per day for 8 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
AZD1981 Midazolam CYP4503A Induction Study
Condition: Healthy Male Volunteer
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of the study is to investigate if the exposure of midazolam is
      clinically significantly changed by 14 days of exposure to AZD1981 through possible enzyme
      induction of CYP3A.
    


Intervention name(s): AZD1981; Midazolam
Intervention type(s): Drug; Drug
Intervention description(s): oral tablets during 14 consecutive days.; Each subject will receive two single doses of 7.5 mg midazolam given as oral solution. The Midazolam dose will be given on Day 1 and on day 16.
Intervention MeSH terms: Midazolam
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Comparing Silicone Hydrogel Contact Lens Wearers to Hydrogel Contact Lens Wearers and Non-lens Wearers
Condition: Myopia
MeSH terms: Myopia
Study type: Interventional

Summary: 
      This study was a multi-site, prospective, randomized, non-masked, unilateral, non-dispensing
      study.
    

Detailed description: 
      The purpose of this study was to to compare physiological response baseline data between 3
      groups - habitual wearers of Daily Disposable Silicone Hydrogel (DDSH) contact lenses,
      habitual wearers of Daily Disposable Hydrogel (DDH) contact lenses, and non-lens wearers. The
      study then compared physiological response data following wear of a low Dk HEMA contact lens
      between habitual wearers of DDSH and habitual wearers of DDH.
    

Intervention name(s): Control; Test Lens
Intervention type(s): Other; Device
Intervention description(s): No lens; Low Dk HEMA contact lens worn for 3 hours
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Denosumab in Treating Patients With Recurrent or Refractory Osteosarcoma
Condition: Metastatic Osteosarcoma; Recurrent Osteosarcoma; Refractory Osteosarcoma; Stage IV Osteosarcoma AJCC v7; Stage IVA Osteosarcoma AJCC v7; Stage IVB Osteosarcoma AJCC v7
MeSH terms: Osteosarcoma; Recurrence
Study type: Interventional
Phase: Phase 2

Summary: 
      This phase II trial studies how well denosumab works in treating patients with osteosarcoma
      that has come back (recurrent) or does not respond to treatment (refractory). Immunotherapy
      with monoclonal antibodies, such as denosumab, may help the body's immune system attack the
      cancer, and may interfere with the ability of tumor cells to grow and spread.
    

Detailed description: 
      PRIMARY OBJECTIVES:

      I. To determine whether denosumab therapy either increases the disease control rate at 4
      months in patients with recurrent measurable osteosarcoma as compared to historical
      Children's Oncology Group (COG) experience or denosumab therapy produces an objective
      response rate greater than 5% (Cohort 1).

      II. To determine whether denosumab therapy increases the disease control rate at 12 months in
      patients with recurrent resected osteosarcoma as compared to historical COG experience
      (Cohort 2).

      SECONDARY OBJECTIVES:

      I. To investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of denosumab in
      subjects with recurrent osteosarcoma.

      II. To describe the tolerability of denosumab in subjects with recurrent osteosarcoma.

      III. To report the disease control rate and objective response rate for patients with
      recurrent osteosarcoma limited to bone.

      IV. To investigate biological markers potentially associated with response to denosumab in
      patients with recurrent osteosarcoma.

      OUTLINE:

      Patients receive denosumab subcutaneously (SC) on day 1 (days 1, 8, and 15 of course 1 only).
      Treatment repeats every 4 weeks (28 days) for up to 24 months or 26 courses, whichever occurs
      first, in the absence of disease progression or unacceptable toxicity.

      After completion of study treatment, patients are followed up monthly for 1 year.
    

Intervention name(s): Denosumab; Laboratory Biomarker Analysis; Pharmacological Study
Intervention type(s): Biological; Other; Other
Intervention description(s): Given SC; Correlative studies; Correlative studies
Other intervention name(s): AMG 162; AMG-162; Denosumab Biosimilar MW032; Denosumab Biosimilar QL1206; Denosumab Biosimilar TK-006; Prolia; TK-006; Xgeva
Intervention MeSH terms: Denosumab
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Integrative Medicine for Hypermobility Spectrum Disorder and Ehlers-Danlos Syndromes (IMforHSDandEDS)
Condition: Ehlers-Danlos Syndrome; Hypermobile EDS (hEDS); Hypermobility Syndrome; EDS
MeSH terms: Ehlers-Danlos Syndrome; Syndrome
Study type: Interventional

Summary: 
      A feasibility study of an integrative medicine program among patients with Hypermobility
      Spectrum Disorder (HSD) or Ehlers-Danlos syndromes (EDS)
    

Detailed description: 
      The overall purpose of this study is to assess the feasibility of conducting a 9-week
      integrative medicine program that is comprised of a prescribed anti-inflammatory
      (Mediterranean) diet, as well as general behavioral and psychosocial support among patients
      with Hypermobility Spectrum Disorder (HSD) or Ehlers-Danlos syndromes (EDS), in order to
      determine the recruitment potential in this population and to measure the ability of
      individuals to complete the program. Participants will be prescribed a food plan, and
      adherence to and feasibility of the food plan will be measured through participant food
      tracking and a subjective assessment of the food plan in a brief satisfaction survey.

      This study aims to recruit 20 patients with HSD or EDS and make preliminary observations
      regarding the effects of integrative medical care on pain reduction and improved quality of
      life.
    

Intervention name(s): Anti-inflammatory (Mediterranean-style) diet; Behavioral and psychosocial support
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Prescription of an anti-inflammatory diet, which encourages increasing whole fruits, vegetables, and grains, as well as balancing macronutrients (proteins, carbohydrates, and fat) for every meal.; Capture a complete and detailed medical history and background. Discuss familial and social support, provide psychosocial support, assess the patient's current self-management strategies for self-care, and assess the patient's current self-management strategies for mental health. Recommendations will be made in accordance with the needs of the participant.
Intervention MeSH terms: Anti-Inflammatory Agents
Intervention model: Single Group Assignment
Intervention model description: Feasibility study
Masking: None (Open Label)
Primary purpose: Other