Effect of St. John's Wort and Olive Oils on the Postoperative Complications
Condition: Impacted Third Molar Tooth
MeSH terms: Tooth, Impacted; Postoperative Complications
Study type: Interventional
Phase: Phase 4

Summary: 
      Surgical removal of impacted third molars is one of the most frequent procedures carried out
      in the oral and maxillofacial surgery clinics. There are a varying range of postoperative
      complications including pain, edema and swelling. Antibiotics, analgesics and mouthwashes are
      usually prescribed for the treatment of these complications. Patients undergoing impacted
      third molar surgery are frequently prescribed chlorhexidine mouthwashes with/without
      benzydamine hydrochloride. However, to preclude the adverse effects of these chemical agents,
      there has been a search for plant-derived alternatives with anti-inflammatory, antibacterial
      and analgesic properties as part of the oral care routine following surgical removal of
      impacted third molars. However, there is no study investigating the comparison of different
      essential oils in the literature. Thus, this multicenter study was aimed to evaluate the
      effects of St. John's wort oil and virgin olive oil on the postoperative complications and
      compared with chlorhexidine gluconate plus benzydamine hydrochloride mouthwash after the
      removal of impacted wisdom teeth.This study was aimed to evaluate the effects of St. John's
      wort oil, virgin olive oil, and chlorhexidine gluconate plus benzydamine hydrochloride on the
      postoperative complications after the removal of impacted wisdom teeth.
    


Intervention name(s): Chlorhexidine Gluconate 0.12 % Mouthwash + benzydamine hydrochloride; St. John's wort oil; Virgin olive oil
Intervention type(s): Drug; Procedure; Procedure
Intervention description(s): After anesthesia, the horizontal incision was made with no. 15 scalpel blade and a full thickness mucoperiosteal flap was raised. In all surgical procedures, bone removal and/or tooth sectioning were performed under abundant irrigation. Following the extraction, granulation tissues were removed, and post extraction cavity was irrigated with sterile 0.9% saline solution. After the bleeding was controlled, the mucoperiosteal flap was repositioned by 3.0 silk sutures. The patients were postoperatively prescribed paracetamol (Parol® 500 mg, Atabay Chemical Industry, Istanbul, Turkey) to use when required with a maximum of 4 doses per day. Patients were instructed to maintain a soft diet, and refrain from mouth washing, brushing and flossing during the first 24 hour. They were also instructed to rinse their mouth with 15 ml of mouthwash for 30 seconds, 3 times a day, and continue until the 7th postoperative day.; After anesthesia, the horizontal incision was made with no. 15 scalpel blade and a full thickness mucoperiosteal flap was raised. In all surgical procedures, bone removal and/or tooth sectioning were performed under abundant irrigation. Following the extraction, granulation tissues were removed, and post extraction cavity was irrigated with sterile 0.9% saline solution. After the bleeding was controlled, the mucoperiosteal flap was repositioned by 3.0 silk sutures. The patients were postoperatively prescribed paracetamol (Parol® 500 mg, Atabay Chemical Industry, Istanbul, Turkey) to use when required with a maximum of 4 doses per day. Patients were instructed to maintain a soft diet, and refrain from mouth washing, brushing and flossing during the first 24 hour. They were also instructed to rinse their mouth with 15 ml of mouthwash for 30 seconds, 3 times a day, and continue until the 7th postoperative day.; After anesthesia, the horizontal incision was made with no. 15 scalpel blade and a full thickness mucoperiosteal flap was raised. In all surgical procedures, bone removal and/or tooth sectioning were performed under abundant irrigation. Following the extraction, granulation tissues were removed, and post extraction cavity was irrigated with sterile 0.9% saline solution. After the bleeding was controlled, the mucoperiosteal flap was repositioned by 3.0 silk sutures. The patients were postoperatively prescribed paracetamol (Parol® 500 mg, Atabay Chemical Industry, Istanbul, Turkey) to use when required with a maximum of 4 doses per day. Patients were instructed to maintain a soft diet, and refrain from mouth washing, brushing and flossing during the first 24 hour. They were also instructed to rinse their mouth with 15 ml of mouthwash for 30 seconds, 3 times a day, and continue until the 7th postoperative day.
Other intervention name(s): Kloroben Oral Rinse
Intervention MeSH terms: Chlorhexidine; Chlorhexidine gluconate; Benzydamine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment