Development of PHY606 as Adjunct Therapy for Anemia Patients
Condition: Anemia; Herbal Interaction
MeSH terms: Anemia
Study type: Interventional
Phase: Phase 3

Summary: 
      Many reasons can cause anemia, decreased RBC production or increased destruction of
      circulation RBC. The investigators investigate the Danggui Buxue Tang (PHY606) composed of
      Angelicae Sinensis Radix and Astragali Radix in the fields of genomic and metabolomics in the
      healthy people and the patiens with anemia.
    

Detailed description: 
      Many reasons can cause anemia, decreased RBC production or increased destruction of
      circulating RBC. The reasons of the former are lake of nutrients, bone marrow disorder, low
      level tropic hormone, inflammation associated with infectious, inflammatory, or malignant
      disorders and the latter are intravascular hemolysis or blood loss. Anemia is characterized
      by the sign of pallor (reduced oxyhemoglobin in skin or mucous membranes), fatigue,
      lightheadedness, and weakness associated with low hemoglobin.

      Iron deficiency anemia (IDA) is mainly resulted from inadequate iron uptake of food,
      malabsorption of iron and blood loss. Adult female are easy to have IDA compared to male
      because of menstruation, pregnancy, lactation and low caloric uptake leading to iron
      deficiency. In Taiwan, cancer-related and chronic kidney disease also lead to insufficient
      secretion of erythropoietin (EPO). The cost of long-term use EPO and its derivative drugs is
      high. Besides, drug resistance, risk of tumor growth and cardiovascular disease are all
      important issues. However, ferrotherapy will induce GI upset, muscle pain and skin hives.
      Also, iron supplementation can lead to an increase in infectious disease morbidity in areas
      where bacterial infections or where malaria are common.

      Based on the concept of dietetic invigoration, the investigators investigate the Danggui
      Buxue Tang (PHY606) composed of Angelicae Sinensis Radix and Astragali Radix in the fields of
      genomics and metabolomics in the healthy people and the patients with anemia. In the
      meantime, the investigators will explore whether PHY606 activates the immune function,
      improves anemia and reduces the side effects induced by anemia treatment. Furthermore, the
      novel metabolites from Angelicae Sinensis Radix and Astragali Radix will be tested from
      clinic back to the bench including immunological potentiation and hematopoietic function.
      According to the TCM theory, the investigators integrate with modern medicine and molecular
      biotechnology to investigate anemia and hope to provide the evidence base for clinical
      application.
    

Intervention name(s): PHY606
Intervention type(s): Drug
Intervention description(s): Danggui Buxue Tang is a well-known TCM formula indicated for anemia through immune modulation and increase energy metabolism
Other intervention name(s): Danggui Buxue Tang
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Anemia; Danggui Buxue Tang; PHY606; Side effects; TCM