bioihbjkbjnl/mcl2 huggingface dataset:
Relation of Consummatory & Anticipatory Food Reward to Obesity
Condition: Obesity
MeSH terms: Obesity
Study type: Observational

Summary: 
      Obesity is associated with increased risk for mortality, atherosclerotic cerebrovascular
      disease, coronary heart disease, colorectal cancer, hyperlipidemia, hypertension, gallbladder
      disease, and diabetes mellitus, resulting in over 111,000 deaths annually in the United
      States (Calle et al., 1999; Flegal et al., 2005). In the US, 65% of adults are overweight or
      obese (Hedley et al., 2004). Unfortunately, the treatment of choice for obesity (behavioral
      weight loss treatment) only results in a 10% reduction in body weight on average and most
      patients regain this weight within a few years (Jeffery et al., 2000). Further, most obesity
      prevention programs do not reduce risk for future weight gain (Stice, Shaw, & Marti, 2006).
      The limited success of treatment and prevention interventions may be due to an incomplete
      understanding of the processes that increase risk for obesity. Recent data suggest that obese
      adults show abnormalities in reward from food intake and anticipated food intake relative to
      lean adults, but the precise nature of these abnormalities is unclear and it has not been
      established whether these abnormalities predate obesity onset or are a consequence. It is
      vital to elucidate risk factors for obesity onset to advance understanding of etiological
      processes and determine the content of prevention and treatment programs.

      The goals of this study are to (1) determine whether adolescents at high-risk for obesity, by
      virtue of having two obese parents, show abnormalities in reward from food intake
      (consummatory food reward) and anticipated reward from food intake (anticipatory food reward)
      compared to adolescents who are at low-risk for obesity, (2) determine whether abnormalities
      in consummatory and anticipatory food reward increase risk for weight gain and obesity onset,
      (3) examine moderators that may amplify the relations of consummatory and anticipatory food
      reward to unhealthy weight gain, and (4) examine changes in consummatory and anticipatory
      food reward in those participants who show obesity onset relative to those not showing
      obesity onset.
    


Intervention name(s): Functional Magnetic Resonance Imaging
Intervention type(s): Other
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        162 lean adolescents between 14-17 years old with BMIs between the 25th and 75th percentile
        at baseline
      
Biospecimen description: 
      Saliva
    
Keywords: fMRI obesity adolescents
Efficacy and Safety of Rivastigmine Capsules in Patients With Probable Vascular Dementia
Condition: Vascular Dementia
MeSH terms: Dementia; Dementia, Vascular
Study type: Interventional
Phase: Phase 3

Summary: 
      The goal of this research study is to evaluate the effectiveness, tolerability and safety of
      rivastigmine capsules in males and females between the ages of 50 and 85 years old with
      probable vascular dementia.
    


Intervention name(s): Rivastigmine
Intervention type(s): Drug
Intervention MeSH terms: Rivastigmine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Dementia,vascular,rivastigmine,stroke,memory loss
Fludarabine / Total Body Irradiation Regimen for ALLO HCT in Acute Lymphoblastic Leukemia
Condition: Adult Lymphoblastic Lymphoma
MeSH terms: Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Lymphoid
Study type: Interventional
Phase: Phase 2

Summary: 
      The goal of this research is to test if the conditioning regimen, fludarabine and total body
      irradiation (FluTBI), can lead to a safer and more effective stem cell transplant treatment
      regimen for ALL patients older than 40 years of age and/or younger patients with high risk
      medical conditions. The primary objective is to establish the efficacy of allo HCT in older
      ALL patients using myeloablative FluTBI conditioning regimen. The investigators are also
      assessing the safety and toxicity of allo HCT in older ALL patients using myeloablative
      FluTBI conditioning regimen.
    


Intervention name(s): Fludarabine; Total Body Irradiation
Intervention type(s): Drug; Procedure
Intervention MeSH terms: Fludarabine
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: ALL
The Effect of Liraglutide Adjunct to Insulin on Glucagon Response to Hypoglycaemia in Subjects With Type 1 Diabetes
Condition: Diabetes; Diabetes Mellitus, Type 1
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1; Hypoglycemia
Study type: Interventional
Phase: Phase 1

Summary: 
      This trial is conducted in Europe. The aim of this trial is to investigate if liraglutide
      adjunct to insulin treatment changes the glucagon response during hypoglycaemia in subjects
      with type 1 diabetes compared with conventional insulin treatment after 4 weeks' treatment
      with liraglutide or placebo.

      Subjects will initially be randomised to one of the three dose groups, and subsequently
      randomly allocated to one of two treatment sequences (liraglutide/placebo or
      placebo/liraglutide).
    


Intervention name(s): liraglutide; placebo
Intervention type(s): Drug; Drug
Intervention description(s): Administered subcutaneously (s.c., under the skin) once daily for 4 weeks.; Administered subcutaneously (s.c., under the skin) once daily for 4 weeks.
Intervention MeSH terms: Liraglutide
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Can B12 and Folate Levels Predict HPV Penetration in Patients With ASCUS?
Condition: ASC-US; Human Papilloma Virus
MeSH terms: Papilloma
Study type: Interventional

Summary: 
      Non-classified atypical squamous cells (ASCUS) is the most common abnormal cervical cytology
      (%39). The risk of cervical intraepithelial neoplasia 2-3 is 5% and the risk of carcinoma is
      around 0.1% after diagnosis. Mostly human papillomavirus (HPV) is responsible for this
      transition. Most of them are transient, but some infections become persistent and can
      progress into precancer and invasive cancer. In the process of progression to cancer;
      patients with cell cycle problems are thought to be at risk. In some studies, B12 and folate
      deficiency, which play a role in DNA synthesis and repair, have been shown to induce
      incorrect binding of uracil to DNA, leading to DNA breakage and repair disorder. Therefore,
      in this study, it has been aimed that the relation of presence of atypical squamous cells and
      HPV persistence with folate and vitamin B12 levels which effect on immune system.
    

Detailed description: 
      Participants were divided into two groups according to their smear results; atypical squamous
      cells of undetermined significance (ASCUS) (study group: 100 patients) and women who did not
      have intraepithelial neoplasia as a result of smear (control group: 100 patients). Patients
      who had well preserved sufficient number of squamous epithelial cells, who did not have
      bleeding, fixation failure, inflammation or atrophy, and had negative cervical cytology smear
      were considered as control group. HPV test was also requested from the study group. B12 and
      folate blood levels were compared between the groups.
    

Intervention name(s): Vitamin B12 and folate
Intervention type(s): Dietary Supplement
Intervention description(s): Vitamin B12 and folate levels in blood
Intervention MeSH terms: Vitamin B 12; Hydroxocobalamin
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: ASCUS; HPV; Vitamine B12; Folate
99mTc-DARPinG3-based HER2 Expression Molecular Imaging in HER2-positive Breast Cancer During Chemo+Targeted Therapy
Condition: HER2-positive Breast Cancer; Female
MeSH terms: Breast Neoplasms
Study type: Observational

Summary: 
      An open-label, single center study with 99mTc-DARPinG3 SPECT and biopsies of primary tumour
      in HER2-positive Breast Cancer in dynamic of chemo+targeted therapy, where the primary
      endpoint of the study is to find out the correlation between the HER2 expression measured by
      99mTc-DARPin G3 SPECT and standard histopathology from primary tumor in dynamic of
      chemo+targeted therapy.
    

Detailed description: 
      none Methodology: Open-label, exploratory, single center study. The subjects will receive a
      single injection of the labelled tracer.
    

Intervention name(s): 99mTc-DARPinG3
Intervention type(s): Drug
Intervention description(s): Diagnostic test (99mTc-DARPinG3-based SPECT) is used for the assessment of the effect of anticancer therapy.
Other intervention name(s): Diagnostic injection of 99mTc-DARPinG3.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Breast cancer female patients.
      
Biospecimen description: 
      Tumor biopsies.
    
Keywords: 99mTc-DARPinG3; Breast Cancer; HER2 expression; chemotherapy and targeted therapy
TactiCath® Prospective Effectiveness Pilot Study
Condition: Paroxysmal Atrial Fibrillation
MeSH terms: Atrial Fibrillation
Study type: Interventional

Summary: 
      EFFICAS II proposes to test the hypothesis that treatment efficacy correlates to contact
      force parameters applied for pulmonary vein isolation (PVI) during AF ablation.
    

Detailed description: 
      EFFICAS II is a single-arm, prospective study, where the operator will have access to contact
      force information and use it actively to optimize the ablation result and adapting power if
      necessary. The endpoint will correlate contact force parameters initially applied in PV and 3
      months PV isolation status, and compare results to those of EFFICAS I.
    

Intervention name(s): Electrophysiology study
Intervention type(s): Other
Intervention description(s): after 3 months to check for pulmonary vein isolation (PVI) status
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Diclofenac Potassium With or Without Vaginal Dinoprostone Prior to Hysterosalpingography
Condition: Infertility, Female
MeSH terms: Infertility; Infertility, Female
Study type: Interventional

Summary: 
      The aim of our study is to determine the efficacy of oral diclofenac potassium with or
      without vaginal dinoprostone prior to hysterosalpingography in primarily infertile patients
      on the pain scores during HSG.
    

Detailed description: 
      hysterosalpingography is a diagnosis procedure in the evaluation of infertile women and
      considered to be the traditional and the gold standard in the assessment of the patency of
      the fallopian tubes. The major disadvantage of hysterosalpingography is pain. In a study
      reported the patients complained of moderate to severe pain during the procedure. It is
      reported that some patients undergoing hysterosalpingography was more stressful and anxiety
      and effect on pain scores.
    

Intervention name(s): diclofenac potassium + dinoprostone; diclofenac potassium + placebo
Intervention type(s): Drug; Drug
Intervention description(s): patients will have of oral diclofenac potassium 60 minutes before the procedure plus one tablets of vaginal dinoprostone (6 mg) 6 hours prior to the procedure by the patient; patients will have of oral diclofenac potassium 60 minutes before the procedure plus one tablets of vaginal placebo 6 hours prior to the procedure by the patient
Intervention MeSH terms: Diclofenac; Dinoprostone
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: double blind placebo controlled trial
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
A Study to Compare Two Paracetamol Formulations.
Condition: Pain
Study type: Interventional
Phase: Phase 1

Summary: 
      A pharmacokinetic study investigating the rate and extent of absorption of paracetamol and an
      adjuvant from two different paracetamol formulations.
    


Intervention name(s): Marketed paracetamol; Experimental paracetamol formulation
Intervention type(s): Drug; Drug
Intervention description(s): Marketed paracetamol; Experimental paracetamol formulation
Intervention MeSH terms: Acetaminophen
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: healthy volunteer; pharmacokinetics; paracetamol
IgE-mediated Allergies Among Type 1 Diabetes Mellitus Children, Single Centre Observational Study
Condition: Diabetic Children
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Observational

Summary: 
      an interviewer-administrated questionnaire was designed to take history of allergy in
      diabetic child come to outpatient clinic fulfilling inclusion criteria and used to collect
      data. Skin prick testing was performed to all diabetic children with history of allergy.
      Laboratory assessment of Serum Total IgE, IL5 and eosinophils%.
    


Intervention name(s): skin prick test
Intervention type(s): Diagnostic Test
Intervention description(s): Skin prick testing was performed to all diabetic child with history of allergy. The recommended method of prick testing includes the appropriate use of specific allergen extracts, positive and negative controls, interpretation of the tests after 15 - 20 minutes of application, with a positive result defined as a wheal ≥3 mm diameter more than negative control for detection of specific IgE to one or more of common aeroallergens.
The location of each allergen was marked with a pen on the volar aspect of forearm to properly identify test results, at least 2 cm from the wrist and the antecubital fossae. The distance between two skin prick tests should be appropriate to avoid false-positive reactions due to direct contamination of a nearby test. A drop of each test solution should be placed on the skin in identical order for each subject tested and immediately pricked with a single-head metal lancet.
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Children with at least 2 years' duration of Type 1 Diabetes Mellitus. Participants: among
        200 cases with Type 1 DM children following up at endocrinology unit
More Time Better Outcome - a Randomised Trial to Investigate the Effect of More Dietetic Time in Dialysis Patients
Condition: Renal Failure
MeSH terms: Renal Insufficiency
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether spending more time with a dietitian will
      improve dietary compliance in a group of hemodialysis patients, with particular respect to
      phosphate control.
    

Detailed description: 
      -  randomised prospective controlled trial

        -  stable haemodialysis patients on thrice weekly haemodialysis (URR > 66%)

        -  either had standard dietetic review - 6 monthly or intensive review - monthly

        -  all patients had to have a serum phosphate > 1.8 mmol/l over the previous three months
           to be recruited

        -  study period 6 months, and then patients followed for a further 3 months
    

Intervention name(s): additional review by dietician
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: hemodialysis; phosphate; calcium phosphate product; dietician; dietetic advice
PEACe: Ivy, Thyme and Cisti Extract (Phytus) Efficacy in Acute Cough
Condition: Cough; Common Cold
MeSH terms: Common Cold; Cough
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to investigate the efficacy of Phytus in Acute Cough
    

Detailed description: 
      Common colds are the most frequently encountered human diseases worldwide. Common cold is a
      conventional term used for mild upper respiratory illnesses, which comprises a heterogeneous
      group of self-limited diseases caused by numerous viruses. The frequency is age-specific with
      fewer episodes in adults than in younger children. Cough due to the common cold is probably
      the most common cause of acute cough. In a significant subset of patients with "post
      infectious" cough, the etiology is probably an inflammatory response triggered by a viral
      upper respiratory infection (ie, the common cold). The resultant sub-acute or chronic cough
      can be considered to be due to an upper airway cough syndrome, previously referred to as
      postnasal drip syndrome.

      Thyme leaf (Thymus vulgaris) expels phlegm and relieves congestion . It is antiseptic and an
      immune stimulant. The primary chemical constituents of Thyme include essential oil (borneol,
      carvacrol, cymol, linalool, thymol), bitter principle, tannin, flavonoids (apigenin,
      luteolin), saponins, and triterpenic acids. Thyme warms and stimulates the lungs, expels
      mucus, and relieves congestion. It also helps deter bacterial, fungal, and viral infections.
      The thymol content of thyme works as an expectorant and cough suppressant and is frequently
      used in cough syrups.
    

Intervention name(s): Phytus (Cisti, Thyme and Ivy Leaves)
Intervention type(s): Drug
Intervention description(s): Phytus is a medicinal herb containing Ivy leaves, Cisti and Thyme.
Other intervention name(s): herbal medicine
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: cough; thyme; Cisti; Ivy Leaves
The Effects of Therapeutic Recreation Activities on Aberrant Behaviours of Individuals With Intellectual Disabilities
Condition: Therapeutic Recreation; Intellectual Disability; Recreational Activities; Aberrant Behaviors
MeSH terms: Intellectual Disability
Study type: Interventional

Summary: 
      The aim of this study was to determine the effect of Therapeutic Recreation Activities on
      Aberrant Behavior of Adolescents With Intellectual Disabilities.

      The research was carried out at Meram Melike Hatun Special Education Vocational School in
      Konya. The study took place between May 2019 and June 2019. The parents of the participants
      who participated in the study consisted of the experimental group (n = 16) and the remaining
      parents (n = 16) formed the control group and the sample group (n = 32). The personal
      information form which measures demographic characteristics developed by the researchers
      according to the literature, and The Aberrant Behavior Checklist Scale were used. Data were
      analyzed in SPSS statistics 23 program. According to Shapiro Wilk test, sample group was not
      normal. For this reason, non-parametric tests were performed. In descriptive data, the mean,
      number, percentage will be used; Comparative statistics were made according to the
      assumptions of non-parametric test (Wilcoxon test, Mann Whitney U test). Therapeutic
      Recreation Activities was applied as total of 16 sessions, consisting of two sessions per
      week and each session lasting about 1 hour. The program was implemented by researcher.
    


Intervention name(s): Therapeutic Recreation Program
Intervention type(s): Behavioral
Intervention description(s): The experimental recreation program, which consisted of two sessions per week and lasted approximately
1 hour each session, lasted for 8 weeks between May 2019 and June 2019 for the adolescents in the experimental group. The Therapeutic Recreation Activity Program, which consists of 16 sessions, is organized according to the self-determination and entertainment development model. This model aims to provide individual development and prosperity by creating an entertaining environment with therapeutic recreation. According to the degree of enjoyment, activity improves freedom of choice, preferences and ability to express oneself. Pleasure is a feeling that the participant feels deeply during therapeutic recreation. Provides entertainment experience. Pleasure increases individual motivation to participate, as well as making the best use of physical, social and emotional conditions
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Dermal Tolerability of Dapsone Gel in Healthy Volunteers
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will determine the cumulative irritation potential and sensitization potential of
      dapsone gel and vehicle after repeat applications on the skin of healthy volunteers.
    


Intervention name(s): dapsone gel; dapsone gel vehicle; sodium lauryl sulfate; Normal saline
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Patches containing dapsone gel will be applied to the skin.; Patches containing dapsone gel vehicle will be applied to the skin.; Patches containing sodium lauryl sulfate (Positive Control) will be applied to the skin.; Patches containing normal saline (Negative Control) will be applied to the skin.
Intervention MeSH terms: Dapsone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Use of Antioxidant in Endometriotic Women to Improve Intracytoplasmic Sperm Injection (ICSI)
Condition: Endometriosis
MeSH terms: Endometriosis
Study type: Interventional
Phase: Phase 2

Summary: 
      ROS plays an essential role in the pathogenesis of many reproductive processes. High
      follicular fluid ROS levels are associated with negative IVF outcomes.

      is plasma level of reactive oxygen species is affected by antioxidant treatment in
      endometriotic women?
    

Detailed description: 
      Study design, size, duration: : prospective randomized controlled clinical trial 50 patients
      with endometriosis diagnosed by US prepared for ICSI were enrolled in the study after
      consent. they were randomized into 2 groups 25 received antioxidants before starting the
      protocol , 25 did not receive . randomization was done by closed envelop single blind for
      patient Participants/materials, setting, methods: was done in the Egyptian centre for IVF
      from March 2013 to October 2013 . 50 patients with endometriosis diagnosed by US prepared for
      ICSI were enrolled in the study after consent. they were randomized into 2 groups 25 received
      antioxidants before starting the protocol , 25 did not receive . all patients were subjected
      to plasma sample before start long protocol for induction and second on day of ovum pick up .
      embryo transfer was done according to embryo grading .
    

Intervention name(s): ascorbate 1000mg, vitamin E 400, zinc and selenium
Intervention type(s): Drug
Intervention description(s): anti oxidant in the form of ascorbate 1000mg, vitamin E 400, zinc and selenium) are given to half patients only before IVF , plasma level of ROS are detected before and on day of oocyte retrieval then correlated to pregnancy outcome
Intervention MeSH terms: Vitamin E; Selenium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: ICSI; antioxidants; ROS; endometriosis