Physical Activity and Protein Supplementation After Bariatric Surgery (PAPAB)
Condition: Bariatric Surgery Candidate
Study type: Interventional

Summary: 
      The purpose of this study is to determine wether regular physical activity in combination
      with protein supplementation after bariatric surgery can reduce the loss of muscle mass and
      wether a computer-assisted exercise program is more effective than a usual exercise program
      regarding frequency of physical activity, fitness and muscular strength.
    

Detailed description: 
      Bariatric surgery has become a major treatment option for severe obesity in adults. Despite
      the advantages of bariatric surgery, attention needs to be paid to the possible risks
      following the surgical treatment. Postoperative risks include protein deficiency and
      pronounced muscle mass loss. Indeed, numerous studies indicate a significant reduction in
      lean body mass resulting from protein deficiency after bariatric surgery.

      Dietary proteins have shown to play an important role in body weight regulation. A
      protein-rich diet attains satiety and thereby facilitates reduction in overall energy intake.
      It has also shown to enhance food-induced thermogenesis. Furthermore, a protein-rich diet -
      ideally in combination with exercise - preserves lean body mass and thus resting energy
      expenditure leading to an improvement of long-term energy balance. Therefore, protein-rich
      diets or protein supplements, respectively, might facilitate weight loss, especially body fat
      loss and protect against loss in muscle mass in patients who underwent bariatric surgery. The
      aim of the present randomized, placebo-controlled, double blind pilot study was to test the
      possible benefit of proteins in combination with exercise in patients undergoing bariatric
      surgery, and to examine, whether computer-assisted exercise is advantageous when comparing it
      to a usual exercise program using written exercise instructions. Therefore, we study the
      influence of postoperative protein supplementation in combination with computer-assisted
      exercise on body composition changes, and body weight reduction, as well as physical fitness,
      protein status and muscle function in obese patients after bariatric surgery.
    

Intervention name(s): Protein; Placebo; Computer-assisted exercise; Usual exercise
Intervention type(s): Dietary Supplement; Dietary Supplement; Behavioral; Behavioral
Intervention description(s): Postoperative intake of 25 g per day starting on the first day after hospital discharge until 6 months postoperatively.; Postoperative intake of 25 g per day starting on the first day after hospital discharge until 6 months postoperatively.; Postoperative regular computer-assisted exercise using Nintendo Wii Mini, Nintendo Wii Balance Board and Wii Fit Plus Software. Exercise is advised to be done 4 times per week.; Postoperative regular exercise using written exercise instructions. Exercise is advised to be done 4 times per week.
Other intervention name(s): Resource Instant Protein 88, Néstle Health Nutrition; Resource Maltodextrin, Néstle Health Nutrition
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Prevention
Keywords: Bariatric surgery; Protein supplementation; Physical activity; Muscle mass; Weight loss; Physical fitness; Muscle strength