bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Assistive Device on ADL Function in Patients With Nerve Injury
Condition: Nerve Injury
MeSH terms: Wounds and Injuries
Study type: Interventional

Summary: 
      Our study is aimed to evaluate the effect of 3D printing assistive device on hand function
      for patients with neural injury.
    

Detailed description: 
      Background: Injury to the central or peripheral nerves can lead to limited hand function and
      further affect the ability of daily life. The use of assistive devices can assist functional
      activities and reduce the phenomenon of non-use. 3D printing technology was used to construct
      personalized, complicated orthosis, and one piece to reduce assembly time. But the evidence
      most are product development, but few of study investigate the effectiveness and it cannot be
      widely used for hand injuries.

      Aim: To evaluate the effect of 3D printing assistive device on hand function for patients
      with neural injury.

      Methods: Thirty neural injury patients were recruited and randomized into experimental (3D
      printing assistive device) or control (universal cuff) groups for 4 weeks of treatment
      (thirty minutes a time, twice a week). The performance was assessed by a blinded assessor
      included Active Range of motion (AROM), Box and block test, Grip dynamometer, upper extremity
      task, Disability of the arm, shoulder and hand questionnaire(DASH), General Health
      Questionnaire(GHQ-12) and Quebec User Evaluation of Satisfaction with Assistive Technology
      (QUEST). The practice performance and adverse effect were recorded. Collected data will be
      analyzed with nonparametric tests by SPSS version 20.0, and alpha level was set at .05.

      Keywords: Neural injury, 3D printing, assistive device, hand function.
    

Intervention name(s): Wear 3D printing assistive device; Wear universal cuff device
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Wear 3D printing aids and engage in functional tasks, including eating, typing, and writing.
At home: use daily, 30 minutes each time; Treatment room: 30 minutes twice a week; Wear universal cuff aids and engage in functional tasks, including eating, typing, and writing.
At home: use daily, 30 minutes each time; Treatment room: 30 minutes twice a week
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Total Knee Arthroplasty With and Without Tourniquet: Comparative Study
Condition: Total Knee Arthroplasty
Study type: Interventional

Summary: 
      Tourniquet use during total knee arthroplasty (TKA) improves visibility and reduces
      intraoperative blood loss. However, tourniquet use may also have a negative impact on early
      recovery of muscle strength and lower extremity function after TKA.Seventy Patients are
      involved in this study and were divided into two groups; Group A (35) patients were treated
      with TKA with pneumatic thigh tourniquet. Group B (35) patients were treated with TKA without
      tourniquet. All patients were suffering from severe knee osteoarthritis and they failed to
      respond to conservative treatment so they are candidates for primary TKA. The two groups are
      matched related to age and gender. Selection of patients into two groups done randomly with
      regard of odd number for group A and even number for group B
    

Detailed description: 
      This study started on March 2016 and ends on October 2018. Seventy Patients are involved in
      this study and were divided into two groups; Group A (35) patients were treated with TKA with
      pneumatic thigh tourniquet. Group B (35) patients were treated with TKA without tourniquet.
      All patients were suffering from severe knee osteoarthritis and they failed to respond to
      conservative treatment so they are candidates for primary TKA. The two groups are matched
      related to age and gender. Selection of patients into two groups done randomly with regard of
      odd number for group A and even number for group B. All patients were followed for a period
      of two weeks until removal of skin sutures for the following parameters:

      Amount of blood transfusion done at and after surgery. Amount of blood drained
      postoperatively through suction drain. Occurrence of postoperative wound hematoma. VAS
      (Visual analogue score) for thigh pain at 1st day and (2) weeks postoperatively.

      Clinical DVT.
    

Intervention name(s): Tourniquet use
Intervention type(s): Procedure
Intervention description(s): Use of Tourniquet in The TKA
Other intervention name(s): No tourniquet use
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: This is comparative study between two groups one treated by Total knee with tourniquet and other group without tourniquet
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Thigh pain; Total knee Arthroplasty; Tourniquet
Comparision of the Clinical Efficacy of Different Desensitizing Toothpastes
Condition: Dentine Hypersensitivity
MeSH terms: Dentin Sensitivity; Hypersensitivity
Study type: Interventional

Summary: 
      Dentin hypersensitivity is a common problem in society. Untreated hypersensitivity affects
      the patient's quality of life, complicates plaque control and increases the risk of caries
      and periodontal disease. This study aimed to evaluate the clinical efficacy of desensitizing
      toothpastes containing sodium fluoride, stannous fluoride, nano-hydroxyapatite, 8% arginine
      and calcium carbonate.

      Fourty eight patients with at least two teeth with positive responses to air and mechanical
      stimulus were included in the study and were divided into four groups. Sodium fluoride
      (Colgate®, Cavity Protection) in group A, stannous fluoride (Oral B® Gum Calm & Sensitivity)
      in group B, nano-hydroxyapatite (ApaCare®) in group C and 8% arginine and calcium carbonate
      combination in group D (Colgate® Sensitive Pro- ReliefTM) were used by the patients
      continuously for 16 weeks. Dentin hypersensitivity, by using VAS and Shiff scores and
      periodontal parameters were evaluated at baseline, 2nd week, 4th week and last 16th week.
    


Intervention name(s): Sodium Monofluorophosphate; Stannous Fluoride; Nano-Hydroxyapatite; 8% Arginine & Calcium Carbonate
Intervention type(s): Other; Other; Other; Other
Intervention description(s): Test toothpaste, participants will brush selected sensitive teeth each for 30 seconds followed by the whole mouth thoroughly for at least one minute. The method of application of these agents will be the fingertip method. Patients continued to use the paste twice daily, morning and evening, for 16 weeks.; Test toothpaste, participants will brush selected sensitive teeth each for 30 seconds followed by the whole mouth thoroughly for at least one minute. The method of application of these agents will be the fingertip method. Patients continued to use the paste twice daily, morning and evening, for 16 weeks.; Test toothpaste, participants will brush selected sensitive teeth each for 30 seconds followed by the whole mouth thoroughly for at least one minute. The method of application of these agents will be the fingertip method. Patients continued to use the paste twice daily, morning and evening, for 16 weeks.; Test toothpaste, participants will brush selected sensitive teeth each for 30 seconds followed by the whole mouth thoroughly for at least one minute. The method of application of these agents will be the fingertip method. Patients continued to use the paste twice daily, morning and evening, for 16 weeks.
Intervention MeSH terms: Calcium Carbonate; Calcium; Fluorides; Tin Fluorides; Fluorophosphate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Dentin Hypersensitivity; Toothpaste; Fluoride; Arginine; Nano-Hydroxyapatite
The Effects of Sphenopalatine Ganglion Acupuncture on Nasal Function
Condition: Healthy
MeSH terms: Ganglion Cysts
Study type: Interventional

Summary: 
      Sphenopalatine ganglion (SPG)-acupuncture has been shown to exhibit distinct effects in
      treatment of nasal inflammatory disease, but the mechanisms remain largely unknown.
      Investigators aimed to assess the effects of SPG acupuncture for nasal ventilation function
      and autonomic nervous system in health volunteers. The randomized, double-blind, controlled
      clinical trial enrolled healthy volunteers.Healthy subjects were randomly assigned to either
      active SPG-acupuncture group or sham-acupuncture group. All subjects were assessed for
      self-reported nasal ventilation, nasal patency (nasal airway resistance (NAR) and nasal
      cavity volume (NVC)), exhaled nasal nitric oxide (nNO) before and after acupuncture.
      Meanwhile, in order to explore underlying mechanisms of SPG acupuncture, the changes in
      neuropeptides (substance P (SP), vasoactive intestinal peptide (VIP) and neuropeptide Y
      (NPY)) in nasal secretions were investigated at baseline, 30 minutes, 2 hours, and 24 hours
      after acupuncture.
    


Intervention name(s): active sphenopalatine ganglion acupuncture; sham sphenopalatine ganglion acupuncture
Intervention type(s): Procedure; Procedure
Intervention description(s): The acupuncture point was selected in the sphenopalatine ganglion (unilateral side). The acupuncture needle was inserted from the lower border of the zygomatic arch, slightly posterior to the suture protuberance between the zygomatic process and temporal process. The needle was rotated until the participant felt "de-qi" sensations.; The acupuncture point was selected same to the sphenopalatine ganglion. But the needle was inserted at the selected acupuncture site to a depth of only 2-3cm, and the procedure of rotating, twirling and thrusting the needle was repeated, in order to blind the subject to the sham treatment.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Acupuncture; Sphenopalatine ganglion; Nasal ventilation; Neuropeptides
Followup of Glenoid Fix Utilizing Auto Bone Graft in Shoulder Replacement
Condition: Arthritis
MeSH terms: Arthritis
Study type: Observational

Summary: 
      This is a case study to evaluate the adequacy of fixation and functional outcome of the
      glenoid anchor peg following autologous bone grafting around the prosthesis at the time of
      implant.
    

Detailed description: 
      To investigate if the use of autologous bone graft around the anchor-peg glenoid prosthesis
      correlates with bony apposition on computed tomography scans, decreased radiolucent lines and
      component loosening, and functional outcomes. We hypothesize that by utilizing autologous
      bone graft from the resected humeral head, placed around the anchor peg glenoid prosthesis at
      implantation, there is a low incidence of glenoid loosening. We suggest that the absence of
      radiolucent lines correlated with excellent shoulder function.
    

Intervention name(s): X-rays and CT scan
Intervention type(s): Procedure
Intervention description(s): CT Scan x-rays
Other intervention name(s): No names
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Maximum number will be 70. Patients who received a total shoulder replacement with an
        anchor peg glenoid and autologous bone grafting from the investigator of this study will be
        recruited for this study.
      
Keywords: Glenoid component; radiolucent lines; Glenoid loosening; glenohumeral arthritis; autologous bone graft
Investigation of PICOPREP and PEG-ELS for Bowel Preparation for Colonoscopy
Condition: Colonoscopy
Study type: Interventional
Phase: Phase 3

Summary: 
      Eligible subjects undergoing a colonoscopy will randomly receive either PICOPREP or
      polyethylene glycol 4000 electrolyte lavage solution before the procedure to evaluate its
      effectiveness, tolerability and safety.
    


Intervention name(s): PICOPREP; PEG-ELS
Intervention type(s): Drug; Drug
Intervention MeSH terms: Picosulfate sodium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Prevalence of Hepatitis B in Vallés Occidental. Observational Multicentric Study
Condition: Hepatitis B
MeSH terms: Hepatitis A; Hepatitis B; Hepatitis
Study type: Observational

Summary: 
      The aim of this study is to evaluate the prevalence of hepatitis B in Vallés Occidental.
      Also, describe the stage of the disease, and whether if they are under medical treatment or
      not.
    

Detailed description: 
      The hepatitis B virus ( HBV ) is a global health problem . It is estimated that in the world
      there are about 350-400 million carriers of HBV surface antigen ( HBsAg ) 1 .

      The prevalence in Spain is estimated at a 2-7 % and is considered a second intermediate
      prevalence.

      For over 20 years, has carried out a program of primary prevention through universal
      vaccination against hepatitis B including it in the childhood vaccination schedule and has
      already been observed that in some estudi3 the prevalence has declined . For this reason , we
      want to evaluate what is the currently prevalence in our area of influence. There aren't
      recent studies to assess what is the current status of these patients ( how many , what risk
      factors which needs of treatment and with answer ...)
    

Intervention name(s): Not apply
Intervention type(s): Other
Intervention description(s): None. Just registration epidemiology dates
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        The are Included consecutively for one year ( 1 June 2014 to 31 May 2015 ) all patients who
        are in the inclusion criteria
A Trial of Treatment for Trauma-Related Nightmares in Active Duty Military Personnel
Condition: Nightmares
Study type: Interventional

Summary: 
      The purpose of this study is to obtain preliminary data of the efficacy of Exposure,
      Relaxation, and Rescripting Therapy for nightmares among active duty military personnel.
    

Detailed description: 
      This will be a pilot randomized controlled trial to compare the effects of Exposure,
      Relaxation, and Rescripting Therapy for military populations (ERRT-M) among active duty
      service members. Participants will be randomized to 5 sessions of ERRT-M (n = 20 ) or to a
      5-week waitlist control group (WL; n = 20).

      Participants will complete all interviews and self-report measures 1 weeks following
      treatment or the WL condition and 1 month after completing treatment.
    

Intervention name(s): ERRT-M for Nightmares
Intervention type(s): Behavioral
Intervention description(s): Exposure, Relaxation, and Rescripting Therapy Military version (ERRT-M) - Five 60-90 minute sessions administered once weekly. ERRT-M includes psychoeducation, sleep habit modification, relaxation training, written exposure to and rescription of nightmare content and imagery rehearsal of rescripted dream content.
Other intervention name(s): Exposure Relaxation & Rescripting
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Cardiorespiratory Performance in Diabetic Elderly
Condition: Diabetics Patients; Hypertensive Patients
Study type: Interventional

Summary: 
      OBJECTIVE: To analyze the influence of lipid control during a cardiorespiratory exercise test
      in two subgroups. DESIGN: Parallel trial study. PARTICIPANTS: The sample consisted of 40
      elderly people, male and female, divided into two groups: 20 hypertensive (G1; 68.50 ±5.85
      years) and 20 diabetic-hypertensive (G2; 68.95 ±6.79 years). MEASUREMENTS: Nutritional
      status; glucose and lipid controls - postprandial glucose (PPG), triglycerides (TG), total
      cholesterol (TC), low density lipoprotein (LDL-C), very low density lipoprotein (VLDL-C),
      high density lipoprotein (HDL-C); blood pressure, and cardiorespiratory performance. The
      significance level was set at p<0.05.
    


Intervention name(s): Cardiorespiratory performance assessment with ergospirometry test; Biochemical analysis
Intervention type(s): Other; Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Diagnostic
A Study to Compare the Actions in the Body of Healthy Subjects of Three Modified Release Formulations of YM178 Under Fasted and Fed Conditions With One Immediate Release Formulation of YM178 Under Fasted Conditions
Condition: Pharmacokinetics of YM178; Healthy Subjects
MeSH terms: Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of the study is to investigate how quickly and to what extent YM178 is absorbed
      and eliminated from the body, and how well it is tolerated, when given in three different
      tablet formulations (sustained release) once a day with and without food, and to compare the
      results with the profile of the YM178 immediate release formulation taken twice daily without
      food.
    

Detailed description: 
      Subjects reside in the clinical research unit for 3 periods of 11 days each, with a washout
      period of at least 7 days between treatment periods. . Each subject is treated with multiple
      oral doses of the IR formulation (b.i.d.) under fasted conditions and, OCAS-F, OCAS-M or
      OCAS-S formulation (q.d.) under fasted and fed conditions (high fat breakfast).

      The study is completed with a post-study visit between 7 and 14 days after discharge of
      period 3.
    

Intervention name(s): YM178 modified release (OCAS); YM178 immediate release (IR)
Intervention type(s): Drug; Drug
Intervention description(s): oral; oral
Other intervention name(s): mirabegron; Myrebtriq; mirabegron; Myrebtriq
Intervention MeSH terms: Mirabegron
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Pharmacokinetics; Phase I; YM178; Modified release (Oral Controlled Absorption System (OCAS)); Immediate release (IR); Fasted conditions; Fed conditions
A Study of Mavrilimumab Versus Anti Tumor Necrosis Factor in Subjects With Rheumatoid Arthritis
Condition: Rheumatoid Arthritis
MeSH terms: Arthritis; Arthritis, Rheumatoid; Necrosis
Study type: Interventional
Phase: Phase 2

Summary: 
      The primary objectives of this study is to explore the efficacy of mavrilimumab compared with
      golimumab in the treatment of adult subjects 18-80 years of age with moderate-to-severe
      active rheumatoid arthritis (RA) who have an inadequate response to one or more conventional
      disease-modifying anti-rheumatic drugs (DMARDs) and/or one or two anti-tumor necrosis factor
      (TNF) agents (excluding golimumab) for efficacy or safety reasons.
    

Detailed description: 
      Despite the therapeutic improvements with recent biologic agents approved for rheumatoid
      arthritis (RA), there is still a significant unmet medical need for the treatment of subjects
      with this chronic disease to achieve a faster, more complete response, and higher rates of
      remission. The aim of the current study is to compare the efficacy and safety of a
      subcutaneous dose of mavrilimumab with a marketed treatment for RA (golimumab) in 120 adult
      subjects with moderate-to-severe active RA who have had an inadequate response to one or two
      anti-TNF agents with mavrilimumab. The design of the study was exploratory and not formerly
      statistically powered.
    

Intervention name(s): Golimumab 50 mg; Mavrilimumab 100 mg
Intervention type(s): Biological; Biological
Intervention description(s): Participants received alternating doses of golimumab 50 mg (Weeks 0, 4, 8, 12, 16, 20, and 24) and placebo matched to mavrilimumab (Weeks 2, 6, 10, 14, 18, and 22) injections subcutaneously every 2 weeks for 24 weeks in combination with stable dose of methotrexate (7.5 to 25 mg per week) through oral or parenteral route.; Participants received Mavrilimumab 100 mg injection subcutaneously every 2 weeks for 24 weeks in combination with stable dose of methotrexate (7.5 to 25 mg per week) through oral or parenteral route.
Other intervention name(s): CAM-3001
Intervention MeSH terms: Golimumab; Mavrilimumab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Rheumatoid Arthritis; Golimumab; Mavrilimumab
Muscle Lipid and Insulin Resistance in the Elderly
Condition: Obesity
MeSH terms: Insulin Resistance
Study type: Interventional

Summary: 
      This project will provide novel information concerning the ability of exercise to enhance the
      capacity for oxidative metabolism of fatty acids and improve insulin resistance in older
      adults who are at high risk for the development of type 2 diabetes. Ultimately this may help
      identify mechanisms and therapeutic targets implicated in skeletal muscle metabolic
      dysregulation. The proposed study is to conduct a randomized controlled exercise training
      intervention trial in older men and women. In addition, the response to exercise in these
      subjects will be compared to those of highly endurance-trained, age-matched athletes.
    

Detailed description: 
      Hypothesis and Specific Aims:

        1. To determine whether aerobic exercise improves both skeletal muscle fat distribution and
           insulin sensitivity of older men and women. We will test two hypotheses.

           i. Physical exercise in older adults will decrease the amount of fat interspersed within
           muscle, specifically the fat between muscle groups (intermuscular adipose tissue) as
           well as decrease specific lipid metabolites within muscle cells, compared to controls.

           ii. Exercise-induced improvements in insulin sensitivity of older men and women will be
           related to the changes in muscle fat content independent of changes in total body fat or
           visceral abdominal adipose tissue.

        2. To determine whether increased capacity for oxidative fatty acid metabolism within
           muscle results in improved insulin sensitivity in older adults. We will test two
           hypotheses.

           i. Exercise training will increase the capacity of muscle to oxidize fatty acids
           assessed both in vitro and in vivo.

           ii. Improved capacity for oxidative fatty acid metabolism will predict improvements in
           insulin sensitivity.
    

Intervention name(s): Exercise Group; Health Education Group
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Sixteen week intervention where subjects will be progressed to four days per week for 45 minutes per session, 180 minutes minimum per week, of moderate intensity supervised exercise.; Sixteen week intervention. This group will not receive specific exercise education or prescription but will be asked to participate in biweekly health education sessions
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Insulin Resistance; Obesity; Exercise Training; Physical Activity