bioihbjkbjnl/mcl2 huggingface dataset:
Comparison Four Intubation Devices
Condition: Intubation
Study type: Interventional

Summary: 
      Comparison of four laryngoscope blades (Miller, Macintosh, Phillips and Wis-Hipple) for
      infant intubation during resuscitation with and without chest compressions.
    


Intervention name(s): MIL; MAC; WIS; PHIL
Intervention type(s): Device; Device; Device; Device
Intervention description(s): Direct laryngoscopy 1; Direct laryngoscopy 2; Direct laryngoscopy 3; Direct laryngoscopy 4
Other intervention name(s): Miller blade; Macintosh blade; Wis-Hipple blade; Phillips blade
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
BAY 77-1931 Long-term Extension From Phase II Study
Condition: Hyperphosphatemia
MeSH terms: Hyperphosphatemia
Study type: Interventional
Phase: Phase 2

Summary: 
      A long-term study of BAY77-1931 (lanthanum carbonate) for hyperphosphatemia in patients
      undergoing hemodialysis
    


Intervention name(s): BAY 77-1931
Intervention type(s): Drug
Intervention description(s): Lanthanum Carbonate (BAY 77-1931)
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Clinical Validation of DACP Digital Design
Condition: Refractive Errors
MeSH terms: Refractive Errors
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the visual performance of DAILIES® AquaComfort Plus®
      (DACP) Digital lenses by assessing distance visual acuity (VA) as compared to DACP sphere
      contact lenses after one week of wear.
    


Intervention name(s): Nelfilcon A digital contact lenses; Nelfilcon A contact lenses
Intervention type(s): Device; Device
Intervention description(s): Silicone hydrogel digital contact lenses; Silicone hydrogel spherical contact lenses
Other intervention name(s): DAILIES® AquaComfort Plus® Digital; DACP Digital; DAILIES® AquaComfort Plus®; DACP
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
Condition: Foot and Ankle Procedures
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this research study to evaluate the effects of dexamethasone as an addition to
      peripheral nerve block (Put the nerve to sleep with Bupivacaine a numbing medication) on
      length of pain relief (analgesia), postoperative narcotic (opioids) requirements, pain
      scores, and patient satisfaction after foot and ankle procedures.
    


Intervention name(s): Dexamethasone; Saline
Intervention type(s): Drug; Drug
Intervention description(s): 0.5% Bupivacaine with 1:200,000 epinephrine + Dexamethasone 4mg per 20cc; 0.5% Bupivacaine with 1:200,000epinephrine + Saline 1 ml per 20cc
Other intervention name(s): Decadron; placebo
Intervention MeSH terms: Dexamethasone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Pain management; Postoperative opioid requirements; Perioperative outcomes; Dexamethasone; Anesthetic adjuvant; Analgesic adjuvant
Usage of Multiple Drugs in Treatment of Postoperative Vomiting After Laparoscopic Appendectomy
Condition: to Treat the Vomiting Frequently Occur Post-laparoscopic by Different Anti Emetic Drugs
MeSH terms: Vomiting
Study type: Observational [Patient Registry]

Summary: 
      To compare and evaluate the antiemetic effect and the safety of ondansetron, inhalational
      isopropyl alcohol and super hydration on adult patients after laparoscopic appendectomy.
    

Detailed description: 
      This prospective double-blind study done on 240 patients admitted to surgical I.C.U after
      laparoscopic appendectomy. Those who had preoperative Koivuranta vomiting score of more than
      3 enrolled in our study. Every group contains 80 patients. Patients of group A received
      ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6
      hours while patients of group B received isopropyl alcohol 70% inhalation every 15 min for 4
      times then repeated after 6 hours. The last group C received intravenous normal saline at
      rate of 20 ml/kg over 30 minute and repeated by the same dose after 6 hours. The duration of
      the study was 24 hours post-operatively. As PONV is self-limited within 24 hours.
    

Intervention name(s): Ondansetron; isopropyl alcohol 70% inhalation; laparoscopic appendectomy
Intervention type(s): Drug; Drug; Procedure
Intervention description(s): ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours while patients of group; inhalation every 15 min for 4 times then repeated after 6 hours; all patients received post operatively after laparoscopic appenectomy
Intervention MeSH terms: Ondansetron
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        240 patients admitted to surgical I.C.U of King Abdul-Aziz specialist hospital for
        post-operative care after laparoscopic appendectomy surgery between March 2019 till
        February 2020. A Koivuranta Score to Predict Postoperative Nausea and Vomiting done
        preoperatively for all the patients and only those who had score of more than 3 on
        Koivuranta vomiting score (had more than 60% chance to develop PONV) enrolled in our study.
        And randomly allocated in one of three groups group A, B or C.
A Clinical Study to Assess the Effect of Food and Gender on the Pharmacokinetics of SRT2104 Administered as an Oral Suspension or Capsule Formulation to Normal Healthy Volunteers
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of this study is to assess the pharmacokinetic profile of a single 500
      mg dose of SRT2104 administered as an oral suspension and a capsule formulation to normal
      healthy male and female volunteers in both the fed and fasted state.

      The secondary objective is to assess the safety and tolerance of SRT2104 administered as an
      oral suspension and as a capsule formulation to healthy male and female volunteers in both
      the fed and fasted state.
    


Intervention name(s): 0.5g SRT2104
Intervention type(s): Drug
Intervention description(s): SRT2104 will be supplied in two forms: as 0.5g powder which will be prepared by the pharmacist/designee into a liquid suspension and as two hard gelatin capsules, each containing 0.25g SRT2104. The dosing vehicle for the liquid suspension is 1% (by weight) hypromellose acetate succinate in water, which is used as a suspension aid and a dispersant for the SRT2104.
Each formulation of test material will be administered orally, in a single dose to the subjects in the fasted state and following consumption of a standard meal. Neither the investigator nor the subjects enrolled will be blinded to treatment assignment.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Turkish Version of the Kinesthetic and Visual Imagery Questionnaire
Condition: Image, Body; Healthy; Pain
Study type: Observational

Summary: 
      Imagery is determined with two strategies to mentally simulate the movements: visual and
      kinesthetic imagery. Visual motor imagery (VMI) is associated with spatial coordinates of a
      movement in the environment and through this speciality VMI applies mainly to the imagery of
      moving objects or to movement of another person in the imagined environment, although imagine
      of own movement is also possible. Kinesthetic motor imagery depends on dynamic relationship
      among the individual, the movement and the environment and it should be determined by the
      nature of the task, the environment and individual characteristics and also requires "feel"
      the movement.

      The aim of this study is to translate this questionnaire into Turkish and the translation in
      terms of its internal consistency, test-retest reliability.
    


Intervention name(s): Determine what the imagery levels are
Intervention type(s): Behavioral
Intervention description(s): Determine the motor imagery: kinesthetic and visual imagery
Other intervention name(s): Determine the motor imagery
Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Healthy volunteers
      
Keywords: motor imagery; kinesthetic imagery; reliability; Turkish version
The Prevalence and Clinical Characteristics of Children With Local Allergic Rhinitis
Condition: Other Allergic Rhinitis
MeSH terms: Rhinitis; Rhinitis, Allergic
Study type: Interventional

Summary: 
      -  To determine prevalence of local allergic rhinitis (LAR)

        -  To evaluate clinical characteristic and severity of local allergic rhinitis

        -  To measure changing of tryptase and Specific IgE for Dermatophagoides pteronyssinus (Dp)
           after nasal allergen provocation test (NAPT)
    

Detailed description: 
      Children 8-18 years with NAR were recruited. A NAPT with Der p 1 solutions (NAPT-DP) at 200
      AU/mL, 600 AU/mL and 2000 AU/mL at 15-minute interval was performed, respectively. The
      immediate responses to NAPT-DP were assessed using symptoms score, peak nasal inspiratory
      flow (PNIF) and acoustic rhinometry (ARM). The nasal tryptase and sIgE-DP were measured at
      baseline, 15 min and 1 h after positive NAPT-DP. Allergic rhinitis (AR) patients were used as
      positive control.
    

Intervention name(s): nasal allergen provocation test
Intervention type(s): Procedure
Intervention description(s): nasal allergen provocation test
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: 1 prevalence; 2 children; 3 local allergic rhinitis
Follow-up Studies of Primary Snoring(PS) and Obstructive Sleep Apnea Hypopnea Syndrome(OSAHS) in Chinese Children
Condition: Obstructive Sleep Apnea Syndrome
MeSH terms: Apnea; Sleep Apnea Syndromes; Sleep Apnea, Obstructive; Syndrome
Study type: Observational [Patient Registry]

Summary: 
      The study is designed to investigate the natural course of Primary snoring in 1-2 years or
      more and the different effect of drug and surgical treatment applied in children with
      obstructive sleep apnea (OSAS) by comparing the polysomnography(PSG) and sleep questionaires
      in 6 months after treatment.
    

Detailed description: 
      The evolution of snoring and OSAS in children is not well established since few studies have
      been published.This study is designed to evaluate the evolution of primary snoring and OSAS
      in children who had been submitted to watchful waiting 、drug or adenotonsillectomy.The
      participated children will be evaluated by full physical examination and nocturnal
      polysomnography（PSG）, after which they were divided into 2 groups: apnea and snoring. After 6
      months following the initial evaluation, patients were submitted to a new nocturnal
      polysomnography, and all data were compared to those of the first examination.And after 3
      months and 12 months following the initial evaluation, patients will be called to complete
      the sleep questionnaire.Then analyse the change of parameters of polysomnography after 6
      months of follow-up,and describe the changes of items of sleep questionnaire.
    

Intervention name(s): Adenotonsillectomy; Conservative treatment; no treatment
Intervention type(s): Procedure; Other; Other
Intervention description(s): Adenotonsillectomy; Mometasone Furoate Aqueous Nasal Spray or uticasone propionate (1/once qd) and（or）Leukotriene antagonists(4 or 5mg/once qn) or H1 receptor antagonists; just regular follow-up
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        PS and OSAHS in Chinese children
      
Biospecimen description: 
      urine
    
Keywords: follow up; Primary Snoring; Obstructive Sleep Apnea Syndrome
Sitagliptin Metformin/PPARg Agonist Combination Therapy Add-on (0431-052)
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 3

Summary: 
      A clinical study to determine the safety and efficacy of sitagliptin in patients with Type 2
      Diabetes Mellitus who have inadequate glycemic control on metformin/peroxisome
      proliferator-activated receptor gamma (PPARg) agonist combination therapy.
    


Intervention name(s): sitagliptin; Comparator: Placebo; rosiglitazone; metformin; glipizide
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): Sitagliptin 100mg tablet each day for 54 weeks. All subjects will be given placebo to sitagliptin for a 2 week period.; Placebo to sitagliptin 100mg tablet each day for 54 weeks.; Subjects taking 4mg or greater rosiglitazone at screening will enter a 6 week stable dose period followed by a 54 week treatment period. Subjects who are taking less than 4mg/day or no rosiglitazone at screening will be titrated to a stable dose of at least 4mg over a a maximum of 8 weeks followed by a dose stable period of up to 12 weeks then a 54 week treatment period. Total treatment will be up to 77 weeks.; Subjects taking 1500mg or greater metformin at screening will enter a 6 week stable dose period followed by a 54 week treatment period. Subjects who are taking less than 1500mg/day or no metformin at screening will be titrated to a stable dose of at least 1500mg over a a maximum of 8 weeks followed by a dose stable period of up to 12 weeks then a 54 week treatment period. Total treatment will be up to 77 weeks.; Subjects not meeting specific glycemic controls during the 54-week treatment period will use glipizide as rescue therapy. Glipizide will be titrated in 5mg doses up to a maximum 40mg each day. (In Canada, the rescue therapy will be a sulfonylurea agent marketed in that country.)
Other intervention name(s): Januvia; Avandia; Glucotrol
Intervention MeSH terms: Metformin; Sitagliptin Phosphate; Rosiglitazone; Glipizide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Type 2 Diabetes Mellitus
A Study of Apatinib and Tegafur Gimeracil Oteracil in Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Condition: Head and Neck Squamous Cell Carcinoma
MeSH terms: Carcinoma; Carcinoma, Squamous Cell; Squamous Cell Carcinoma of Head and Neck
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a non-randomized, phase II, open label study of apatinib mesylate tablets plus
      tegafur gimeracil oteracil potassium capsules induction chemotherapy in locally advanced
      squamous cell carcinoma of head and neck patients who were judged surgically unresectable or
      appropriate for non-surgical definitive therapy.The primary purpose of this study is to
      evaluate the efficacy of apatinib mesylate tablets plus tegafur gimeracil oteracil potassium
      capsules in locally advanced squamous cell carcinoma of head and neck
    


Intervention name(s): Apatinib Mesylate Tablets; Tegafur Gimeracil Oteracil Potassium Capsules
Intervention type(s): Drug; Drug
Intervention description(s): 500 mg qd.p.o. every day for 21 days as a cycle; 25mg/㎡ bid p.o. every day for 14 days as a cycle
Other intervention name(s): Aitan; Aiyi; S-1
Intervention MeSH terms: Apatinib; Tegafur
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: head and neck cancer; Apatinib; Tegafur Gimeracil Oteracil; induction chemotherapy
Effect of ACP-501 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Subjects With Coronary Artery Disease
Condition: Coronary Artery Disease; Atherosclerosis
MeSH terms: Coronary Artery Disease; Myocardial Ischemia; Coronary Disease; Atherosclerosis
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is a phase 1, intravenous, open-label, single-dose escalation study to evaluate
      the safety, tolerability, pharmacokinetics and pharmacodynamics of ACP-501 (recombinant human
      Lecithin Cholesterol Acyl Transferase (rhLCAT)) in subjects with coronary artery disease
      (CAD). Four cohorts consisting of 4 subjects each will receive one dose of ACP-501. The dose
      will be escalated by cohort.
    

Detailed description: 
      After signing informed consent, subjects entered into the trial will be followed for up to 8
      weeks which includes: up to 4 weeks screening, entry criteria assessments on Day 0 and
      single-dose IV infusion on Day 1, and 4 weeks of follow-up.
    

Intervention name(s): ACP-501
Intervention type(s): Drug
Intervention description(s): A single dose infusion
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Lecithin Cholesterol Acyl Transferase; LCAT; rhLCAT; Enzyme replacement therapy; High-Density Lipoprotein (HDL); Cholesterol; Cholesterol ester; LCAT Deficiency
The Purpose of This Study Was to Determine Whether or Not Functional Training Has Similar Effects on Muscular Strength, Flexibility, Agility, Speed and Anthropometric Measures in Basketball Players as Traditional Resistance Training
Condition: Basketball; Exercise
Study type: Interventional

Summary: 
      Basketball has gained worldwide popularity and fascinated players and spectators with its
      dynamic characteristics as a team sport. This kind of sport is multifaceted that requires
      well-developed physical ﬁtness to be played successfully. Many authors have suggested that
      strength, power, agility, and speed are important performance related physical components for
      elite basketball players. The physical components require that fitness and conditioning
      attributes of basketball players are well developed to negate the limiting aspect of sport
      performance. Moreover, functional training is becoming increasingly popular within the
      fitness industry and has been considered to be a better alternative than traditional training
      methods for improving various measures of performance. The purpose of this study was to
      determine whether functional training has effects on performance and related various physical
      components of basketball players.
    


Intervention name(s): Functional Training
Intervention type(s): Other
Intervention description(s): Functional training has been defined as emphasizing multiple muscle and joint activities, combining upper and lower body movements, and utilizing more of the body in each movement. The primary goal of functional training is to transfer improvement achieve in one movement to enhancing the performance of another movement by affecting the entire neuromuscular system.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Functional; Training; Performance
Improvement of Body Image Flexibility in High School Female Athletes Doing Educational About Nutrition and Body Image
Condition: Body Image; Nutrition, Healthy
Study type: Observational

Summary: 
      Evaluation of increase in body flexibility in female high school athletes undergoing
      education on nutrition and body image
    

Detailed description: 
      This study was a prospective cohort design. Female high school athletes were asked to
      participate in three educational sessions about nutrition, body image flexibility, and RED-S
      (relative energy deficiency in sport). Pre and post-tests were done with a validated tool
      measuring body image flexibility.
    

Intervention name(s): Education
Intervention type(s): Other
Intervention description(s): 3 educational sessions about body image and nutrition
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        These are athletes at local high schools who identify as female. The demographic area is
        primarily socioeconomically middle class.
Study Evaluating SOM230 in Patients With Metastatic Carcinoid Tumors
Condition: Carcinoid Tumors
MeSH terms: Carcinoid Tumor
Study type: Interventional
Phase: Phase 2

Summary: 
      Study evaluating SOM230 in patients with metastatic carcinoid tumors
    


Intervention name(s): Pasireotide (SOM230)
Intervention type(s): Drug
Intervention description(s): Open label. Patients received starting dose of 300 µg of study drug subcutaneously (s.c.) twice (total of 600 µg ) daily for three days, which could be increased in 150 µg increments up to 900 µg twice daily (total 1800 µg daily) if control of symptoms was not achieved. Prior sponsor agreement was required for a higher dose. A dose of 2400 µg/day was the maximum allowed. Dose reductions of 300 µg/day were allowed at any time if unacceptable toxicity occurred.
Other intervention name(s): SOM230
Intervention MeSH terms: Pasireotide
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: SOM230; Sandostatin; Carcinoid syndrome
Sorafenib Alone Versus Sorafenib Combined With HAIC for Advanced HCC
Condition: Hepatocellular Carcinoma
MeSH terms: Carcinoma, Hepatocellular
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to evaluate the efficacy and safety of sorafenib combined with
      hepatic arterial infusion chemotherapy (HAIC) compared with sorafenib Alone in patients with
      hepatocellular carcinoma (HCC) with major portal venous tumor thrombus (PVTT).
    

Detailed description: 
      The results of our preliminary pilot study suggested that sorafenib combined with hepatic
      arterial infusion chemotherapy (HAIC) may improve the survivals for advanced stage HCC. Thus,
      the investigators carried out this prospective randomized control study to find out it.
    

Intervention name(s): Sorafenib; Hepatic arterial infusion chemotherapy; Folfox Protocol
Intervention type(s): Drug; Procedure; Drug
Intervention description(s): administration of Sorafenib; administration of Oxaliplatin , fluorouracil, and leucovorin via the tumor feeding arteries; Oxaliplatin , fluorouracil, and leucovorin
Other intervention name(s): HAIC; Oxaliplatin , fluorouracil, and leucovorin
Intervention MeSH terms: Leucovorin; Fluorouracil; Oxaliplatin; Sorafenib
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Hepatocellular Carcinoma; Hepatic arterial infusion chemotherapy; Sorafenib