bioihbjkbjnl/mcl2 huggingface dataset:
Orange Juice Consumption and Glucose Metabolism and Antioxidative Status
Condition: Healthy
Study type: Interventional

Summary: 
      Aim of the study is to investigate the impact of orange juice consumption (with meals or
      between meals) as well as sugar sweetened beverage (SSB) consumption (between meals) on
      glucose homeostasis and antioxidative status.
    

Detailed description: 
      Duration of the study is 3x three weeks including one wash-out week each followed by two
      weeks of juice/SSB consumption under free living conditions.

      During wash-out weeks consumption of orange juice or citrus fruits is restricted.

      During intervention weeks, participants are asked to eat three regular meals per day without
      snacking. Intervention weeks are (i) orange juice consumption with meals (ii) orange juice
      consumption between meals and (iii) SSB consumption between meals. Daily energy intake with
      orange juice/SSB is 20% of individual energy requirement. Additional caloric beverages (SSB,
      juice, coffee with sugar/milk, alcohol) are not allowed. At the beginning and the end of each
      intervention phase insulin sensitivity and antioxidative status are assessed.
    

Intervention name(s): Orange juice with meals; Orange juice between meals; Sugar sweetened beverage between meals
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): orange juice (20% of energy requirement/day); orange juice (20% of energy requirement/day); Sugar sweetened beverage (20% of energy requirement/day)
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: orange juice consumption; glucose homeostasis; antioxidative status
A Survey of Patient's Attitudes Towards Consent For Clinical Research In Anesthesiology
Condition: Informed Consent
Study type: Observational

Summary: 
      In most current academic anesthesia groups, it appears that consent for research is acquired
      on the day of surgery. This practice raises concerns because the hospital may be regarded as
      a coercive environment and there may be the possibility that the immediate preoperative
      environment prohibits adequate time for understanding the research project and making an
      informed decision about participation. However, this is often the only opportunity for
      anesthesiologists to obtain research consent. The aim of the present investigation is to
      utilize a survey study to determine if patients at Evanston Hospital are comfortable
      consenting for research on the day of surgery
    

Detailed description: 
      Patients participating in approved, minimal risk clinical research projects will be
      approached by the study investigators. Consent for clinical research will be obtained on the
      day of surgery in the ambulatory surgery unit. In addition, some patients will be contacted
      by telephone on the day prior to surgery to be informed that they will be approached about
      participation in a research project. If patients agree to participate in the clinical trial,
      they will be provided with a self-addressed envelope containing the survey and a brief cover
      letter. The research team member will explain the purpose of the survey (to determine
      patients' attitudes towards research consent on the day of surgery). Subjects will be
      requested to complete the survey within a week of the surgical procedure. Two days after
      surgery, the research team will provide a follow-up call to determine if there are any
      questions about completing the survey. Although patient names will not be identified on the
      survey packet, all surveys will be coded with the subjects study number for subsequent
      analysis.

      Questions are designed to investigate six areas of potential concern relating to informed
      consent; comprehension, situation (privacy/time), obligation (pressure) motivation,
      compunction (regrets), and satisfaction. Subjects will reply using a 5-point scale from
      1=strongly disagree to 5=strongly agree.
    

Intervention name(s): Phone call explaining the research project
Intervention type(s): Other
Intervention description(s): A phone call on the day before surgery will be provided to subjects explaining the nature of the clinical trial
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients participating in approved, minimal risk clinical research projects in the
        Department of Anesthesiology at NorthShore University HealthSystem will be approached by
        the study investigators.
      
Keywords: Informed consent; Perioperative period; Morning of surgery; Anesthesiology
Clinical Evaluation of the Efficacy of Fractional Radiofrequency for the Treatment and Reduction of Stretch Marks
Condition: Stretch Mark
MeSH terms: Striae Distensae
Study type: Interventional

Summary: 
      This is a prospective, single centre, evaluator-blind study of the performance of fractional
      radiofrequency (RF) for the treatment and revision of stretch marks. The study will evaluate
      the progress of 15 subjects requesting treatment of stretch marks. The study will involve
      four treatments on both sides of the face with 4 week intervals between each treatment.
      Subjects will be followed at 12 and 16 weeks after their last treatment. Analysis will be
      performed on all subjects who receive at least one treatment.
    


Intervention name(s): Venus Viva
Intervention type(s): Device
Intervention description(s): The Venus Viva™ fractional RF device has been shown in clinical studies to improve various skin conditions related to aging and alter collagen structures such as wrinkles, stretch marks, rhytids and scars. Beginning with the Baseline visit (Visit 1), subjects will receive a total of 4 treatments approximately 4 weeks apart.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Balance Training Using Biodex Stability System in Knee Osteoarthritis.
Condition: Knee Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional

Summary: 
      This was a randomized control Trial, conducted with two group of patients, one has received
      Balance and stability training on Biodex stability system along with conservative protocol of
      traditional exercises. the other group has received only conservative protocol of traditional
      exercises
    

Detailed description: 
      Patients with Symptomatic Knee Osteoarthritis have balance and stability deficits. In routine
      such patients are not evaluated and treated on balance and stability parameters. So this
      study was conducted with objectives to determine the effects of Balance training using Biodex
      stability system in patients with symptomatic knee osteoarthritis.

      Experimental group has received Balance and stability training on Biodex stability system
      along with conservative protocol of traditional exercises.

      Control group has received only conservative protocol of traditional exercises.
    

Intervention name(s): Balance Training; Conventional Training
Intervention type(s): Other; Other
Intervention description(s): Experimental group received balance training on Biodex stability System along with traditional exercise program. During balance training on Biodex, patients were instructed to stand on the platform with bare feet with open eyes and both legs supported. Patients were looking forward to screen having hands hang by the sides. The patients were instructed not to change their feet position and balance the body. The handles were accessible for safety point. But touching the handles cancelled the trail. Total time of training was 10 minutes each set is of 3 minutes with 20 sec rest intervals.; Control group has received traditional exercises i.e Quadriceps strength exercises, Hamstrings flexibility exercises and Balance exercises.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Parallel Assignment of patients into two groups
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Balance Training; Biodex stability system; Osteoarthrosis; Degenerative; Stability exercises
Comparison of Intravenous Co-amoxiclav Versus Benzyl Penicillin
Condition: Tonsillitis Streptococcal
MeSH terms: Tonsillitis
Study type: Interventional

Summary: 
      To compare intravenous Co-amoxiclav versus Benzyl penicillin in children with severe
      streptococcal tonsillitis in terms of efficacy, safety and cost effectiveness.
    

Detailed description: 
      Efficacy was measured through improvement (decrease in fever, settling lymphadenopathy and
      disappearance of tonsillar exudate) in Centor Criteria score on daily basis. Improvement i.e
      reduction in Centor Criteria score was recorded for all children till full recovery.

      Safety was measured by frequency of hypersensitivity reactions or severe side effects of
      antibiotics necessitating stoppage of the drug. All the children in both Groups were given
      test dose of the antibiotic before giving full dose of antibiotic prescribed.

      Cost effectiveness was compared in terms of total cost of injections (Co-amoxiclav versus
      Benzyl penicillin) which were administered to children in both groups.
    

Intervention name(s): inj co-amoxiclav 50 units/kg/day vs inj Benzyl Penicillin 25000 units/kg/day
Intervention type(s): Drug
Intervention description(s): Patients of both groups were examined and compared in terms of efficacy of treatment, safety and cost effectiveness
Other intervention name(s): Group A and B
Intervention MeSH terms: Penicillins; Amoxicillin-Potassium Clavulanate Combination; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: single blinded clinical trial
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Co-amoxiclav; Benzyl Penicilli; Tonsillitis
Effects of "Music for the Mind" on Pre-operative Anxiety in Dentistry
Condition: Dental Anxiety
MeSH terms: Anxiety Disorders
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      To examine the pre-operative effect of music for the mind compared to some other styles of
      music in patients undergoing dental procedures.
    

Detailed description: 
      120 patients were sequentially assigned to four groups of 30 subjects. the music groups
      received Music for the mind, Iranian traditional music and Mozart music through headphone for
      ten minutes prior to dental procedures, and the control group received silence through
      headphone. anxiety score and pulse rate and blood pressure were measured before and after
      receiving music
    

Intervention name(s): Music
Intervention type(s): Behavioral
Intervention description(s): Ten minutes of music or silence were applied prior to dental procedures
Other intervention name(s): Music for the mind; Mozart Music; Iranian Music
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Music; dental anxiety; "music for the mind"; mozart; iranian traditional music
A Hepatic Impairment Study for PF-04965842.
Condition: Hepatic Impairment
MeSH terms: Liver Diseases
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a Phase 1 non randomized, open label, single dose, parallel cohort study to
      investigate the effect of hepatic impairment on the PK, safety and tolerability of PF
      04965842.
    

Detailed description: 
      A minimum of 24 subjects with normal, mild or moderate hepatic function will be enrolled into
      the study, with approximately 8 subjects in each cohort. The Child Pugh classification score
      will be utilized to assess entry criteria and to assign subjects into the appropriate hepatic
      impairment group. For individual subjects, the total maximum duration of study participation
      from the Screening visit to the end of clinical research unit (CRU) stay is approximately 31
      days and approximately 63 days from the Screening visit to the Follow up contact.
    

Intervention name(s): PF-04965842
Intervention type(s): Drug
Intervention description(s): PF 04965842 is an orally bioavailable small molecule that selectively inhibits JAK1.
Intervention MeSH terms: Abrocitinib
Intervention model: Parallel Assignment
Intervention model description: Recruitment for subjects with moderate and mild hepatic impairment (Cohorts 1 and 2) will initiate first and these subjects will be enrolled in parallel.
Masking: None (Open Label)
Primary purpose: Basic Science
Effects of a High Intensity Resistance Training in Muscular Strength, Agility, and Body Composition of Anorexia Nervosa Restricting Type Patients
Condition: Anorexia Nervosa Restricting Type
MeSH terms: Anorexia; Anorexia Nervosa
Study type: Interventional

Summary: 
      The aim is to test the hypothesis that high-resistance training for 8 weeks, following the
      recommendations for healthy adolescents, is capable of eliciting increases in muscle
      strength, agility, skeletal muscle mass, and functional capacity without losing weight, body
      mass index (BMI) or fat mass in anorexia nervosa restricting type patients. Further, we
      hypothesize that the effects produced by the high-resistance training program will be
      maintained 4 weeks following the completion of the training program.
    


Intervention name(s): High-Intensity Resistance training
Intervention type(s): Behavioral
Intervention description(s): Intervention group performed 3 weekly sessions during 8 weeks in the intra-hospital gymnasium. Each session lasted 50-60 min, and started and ended with warm-up and cool-down periods (10-15 min).
The core session included bench press, leg press, lateral row, leg extension, lateral pull-down, abdominal crunch, low back extension, and push-ups exercises. The participants performed three sets of 8-10 repetitions with resting periods of 1-2 min on the weightlifting machines. Load was gradually increased 5-10 % as the participant strength was adapted. The load started at 70% of 6RM.
Functional exercises (abdominal crunch, low back extension, and push-ups) were performed at the end of the session to strengthen the core musculature consisting of 3 sets of 15s of isometric contractions at the beginning of the program and 30 s at the end. Dynamic contractions were added, starting with 10 repetitions at the beginning to 30 repetitions at the end of the program.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: anorexia nervosa; restricting type; muscle strength; exercise; body composition; physical activity
Very Low Calorie Liquid Diet for Pre op Patients
Condition: Morbid Obesity; Steatosis
MeSH terms: Obesity, Morbid
Study type: Interventional

Summary: 
      Despite the relative consensus on the benefits of pre-surgical weight loss, i.e., the
      reduction of comorbidities associated with surgical act, such as decreased visceral fat,
      liver volume, hemorrhage perioperative and surgical time, the characteristics of the diet to
      be employed in this period need to be defined more clearly. As there is no description of
      comparative studies on diet of normal consistency, using solids and liquids, there are doubts
      as to the real need for consistency liquid diet in preoperative bariatric surgery. The lack
      of robust evidence has made nutrition professionals adopt different procedures. There is
      still a belief that these patients are unable to lose weight in the preoperative period, the
      ongoing history of previous attempts without success.
    


Intervention name(s): A very low calorie diet of two different consistencies
Intervention type(s): Other
Intervention description(s): Liquid and normal consistency diet with a very low calorie diet will be given to patients pre-operatively in bariatric surgery
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Very low calorie diet; liquid diet; visceral fat; liver fat.
Cross Over Study to Prove Bioequivalence Between Two Brands of Cefalexin Suspension
Condition: Anti-Infective Agents
Study type: Interventional
Phase: Phase 1

Summary: 
      A single dose, two treatments (two cephalexin suspension brands), two sequences, cross-over
      design was used with a washout of 7 days between the two study periods. Treatment groups
      balanced with the same number of healthy volunteers who were randomly (in two strata: male
      and female) assigned to the study drug administration sequences
    


Intervention name(s): Cephalexin suspension (Optocef, BAYO5448 ); Cephalexin suspension (Keflex)
Intervention type(s): Drug; Drug
Intervention description(s): Single dose of 500 mg / 10 mL; Single dose of 500 mg / 20 mL
Intervention MeSH terms: Cephalexin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Drug Interactions When DA-8010 is Co-administered With Paroxetine or Mirabegron in Healthy Adults
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This is an open-label, 2-Part, phase 1 study to evaluate drug interactions when DA-8010 is
      co-administered with Paroxetine or Mirabegron in healthy adult subjects
    


Intervention name(s): DA-8010 5mg; Paroxetine 20mg; Mirabegron 50mg
Intervention type(s): Drug; Drug; Drug
Intervention description(s): [Part 1] DA-8010 5mg + Paroxetine 20mg [Part 2] DA-8010 5mg + Mirabegron 50mg; [Part 1] DA-8010 5mg + Paroxetine 20mg; [Part 2] DA-8010 5mg + Mirabegron 50mg
Intervention MeSH terms: Paroxetine; Mirabegron; DA-8010
Intervention model: Single Group Assignment
Intervention model description: 2-part
Masking: None (Open Label)
Primary purpose: Treatment
Effects of Consent Methods Performed According to Intelligence Types on Anxiety Associated With Third Molar Surgery
Condition: Dental Anxiety
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      The aim of this study is to investigate the effect of information provided in accordance with
      intelligence type on anxiety associated with wisdom tooth surgery.
    

Detailed description: 
      The participants who will undergo third molar surgery divided into study and control groups.
      Study group divided further into three groups according to multiple intellegence test.
      Ultimately four groups created as follows;

        1. Control: The group with standard (written and verbal) information without multiple
           intelligence test

        2. Visual/Spatial: The group with higher visual intelligence according to the multiple
           intelligence test results and watch video. Also, will given with a written informed
           consent document.

        3. Verbal/Linguistic: The group with higher verbal/linguistic intelligence according to the
           multiple intelligence test results and verbally informed in detail about the operation.
           lso, will given with a written informed consent document

        4. Bodily/Kinesthetic: The group with higher bodily/kinesthetic intelligence according to
           the multiple intelligence test results and informed with a dental model. lso, will given
           with a written informed consent document To evaluate anxiety; participants will asked to
           complete MDAS questionnairre before and after consent, and after operation. Also, saliva
           samples will obtained to evaluate the salivary cortisol before and after consent, and
           after operation.
    

Intervention name(s): Informed consent; Third molar surgery
Intervention type(s): Behavioral; Procedure
Intervention description(s): The style of informing patients about the procedure they will undergo; Surgical extraction of the third molar tooth
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Screening
Unilateral Deep Brain Stimulation (DBS) of the Nucleus (Nucl.) Accumbens (Acc.) in Patients With Treatment Resistant Obsessive Compulsive Disorder (OCD)
Condition: Obsessive Compulsive Disorder
MeSH terms: Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Study type: Interventional

Summary: 
      The purpose of the study was to evaluate whether a unilateral Deep Brain Stimulation of the
      right Nucleus Accumbens could lead to a more than 35% reduction of symptoms in patients with
      a treatment resistant Obsessive Compulsive Disorder within two years.
    

Detailed description: 
      From the late ninety's on, a few work groups published the case series of patients with
      treatment resistant OCD undergoing deep brain stimulation (DBS). This stereotactical method
      involves surgically implanted electrodes and previously has been used primarily for the
      treatment of Parkinson's disease and tremor.

      In almost all reported cases, a bilateral stimulation in the anterior limb of the internal
      capsule (ALIC was applied. However, the electrode designs between the groups varied and in
      some cases the stimulation area was extended to the adjacent ventral striatal regions
      including the nucleus accumbens (NAC).

      Cortical-striate-thalami-cortical (CSTC) circuits are supported to be implicated in the
      pathogenesis underlying OCD caused by a failure of inhibition of the ventral striatum.
      Together with other structures the nucleus accumbens forms the ventral striatum. Because of
      the predominant role of the NAC to exert modulatory effects within these circuits we
      considered it to provide a promising target location for DBS.

      Moreover the NAC ventrally borders with the anterior limb of the internal capsule and the
      subventricular lateral fundus of the nucleus accumbens is even permeated in rostral sections
      by numerous internal capsule fiber bundles. It was therefore to be expected that the
      electrode trajectories and stimulation target selected by us additionally would have an
      effect on the fibre systems of the internal capsule.

      The NAC had been introduced as primary target for DBS in treatment resistant OCD by our
      group. Pilot series showed that the right stimulation of the NAC yielded the best results,
      whereas bilateral stimulation showed no additional benefit.
    

Intervention name(s): Deep Brain Stimulation
Intervention type(s): Procedure
Intervention description(s): Unilateral Deep Brain Stimulation in the right Nucleus Accumbens
Other intervention name(s): Model 3387 DBS Lead, Medtronic, Minneapolis, USA
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Deep Brain Stimulation; Obsessive Compulsive Disorder; Nucleus Accumbens