Clinical Application of Patented Lyophilized PLT in Acne Scar Repairment.
Condition: Atrophic Acne Scar
MeSH terms: Acne Vulgaris
Study type: Interventional

Summary: 
      All kinds of skin problems will cause a person's life caused by varying degrees of trouble,
      especially issues at face. No matter diseases or aging would cause mental pressure and the
      inconvenience in different ages.

      Scar caused by acne is the most common skin issue amount young people. While acne recovering,
      due to the destruction of collagen forming fibrous tissue, and scars be left. Clinical
      treatments are facial laser, argon laser and carbon dioxide laser. With the combination of
      rejuvenation to accelerate growth of collagen when needed. According to journal articles,
      facial laser combined with Platelet-rich plasma is more curative than facial laser treatment
      alone and can significantly reduce side effects (Dermatol Surg. 2014 Feb;40(2):152-61).

      Platelet has been valued in regeneration medicine due to its various growth factors with
      repairment, induction and promotion functions. Moreover, low risk of allergy for it is an
      autologous material. Platelet had been officially applied in orthopedics and more clinical
      studies in many other fields. Nowadays, preparation of PRP is by single-use centrifuge tube,
      patients have to go through blood collection process every time before therapy due to short
      shelf life of PRP. Meanwhile, amount of platelet in PRP would be different due to difference
      of individual, health condition and separation methods. Thus, leaving unknown of active
      principle and uncertainty of treatments.

      In this trial, a patented technique of lyophilized PLT preparation method is applied, collect
      250 c.c. of blood specimen by using blood bag, separate platelet in germ-free clean room,
      then lyophilize platelet to extend shelf life to at least three years after quantifying
      platelet amount. Therefore, treatment could be done after simple dissolution process of PLT
      leads to the convenience of multiple therapy lessons.
    


Intervention name(s): PLT; Saline
Intervention type(s): Other; Other
Intervention description(s): The study will be conducted by using a fractional carbon dioxide laser for acne scar treatment. After the treatment, each patient enrolled will be applied 2 mL PLT solution on the right face. Treatment mentioned above will be repeated every 3 to 4 weeks, overall 4 times treatment and one month follow up after fourth treatment. Every record will be documented in questionnaires by the principal investigator and the patient itself. Moreover, VISIA is applied for objective observation, such as spots, wrinkles, texture, pores, UV spots, brown spots, red area, and porphyrins could be objectively analyzed.; The study will be conducted by using a fractional carbon dioxide laser for acne scar treatment. After the treatment, each patient enrolled left face be applied 2 mL normal saline.
Treatment mentioned above will be repeated every 3 to 4 weeks, overall 4 times treatment and one month follow up after fourth treatment. Every record will be documented in questionnaires by the principal investigator and the patient itself. Moreover, VISIA is applied for objective observation, such as spots, wrinkles, texture, pores, UV spots, brown spots, red area, and porphyrins could be objectively analyzed.
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Intervention model description: A prospective, single-blind, parallel study at a single health care center.
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Platelet; PLT; Growth factor; Acne scar repairment; Laser