Efficacy of Desensitizing Agent,Propolis After an In-office Vital Tooth Bleaching.
Condition: Post Operative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      This study was conducted to evaluate the efficacy of desensitizing agent Propolis, after an
      in -office vital tooth bleaching and to compare its desensitizing effect to traditionally
      used desensitizing agent fluoride varnish.

      Methods: Considering the inclusion and exclusion criteria 90 patients will be selected at the
      OPD of Dow University of Health Sciences Ojha campus with mild to moderate discoloration and
      randomly divided in to three groups group A control group (fluoride varnish) group B Propolis
      and group C Propolis mixed with bleaching agent. After performing the bleaching procedure
      respective desensitizing agent was applied to each group for 10 minutes. Visual analogue
      scale and Schiff's scale were used to assess the sensitivity after completion of treatment.
      Subjective non stimulated assessment of sensitivity was done by using the visual analogue
      scale from day 1 till day 7 on given Performa and Objective stimulated assessment of
      sensitivity was done at the dental office on day 1 right after the procedure and at day 7 on
      follow-up after one week.

      Kruskal-Wallis test was applied to check median pain score and sensitivity difference between
      and among the groups. Mann-Whitney U test was applied to check further pairwise comparison
      between the groups.
    

Detailed description: 
      Dental aesthetic is one of the great importance to the patients, various causes of tooth
      discoloration which usually encountered are dental fluorosis, aging, staining, smoking,
      medication use, etc. Different treatment options are available to treat discoloration depends
      on the individual case. Dental bleaching is one of the most conservative, noninvasive, low
      cost effective treatment modality to treat discoloration. In vital tooth bleaching dentists
      use 35 to 38 % hydrogen peroxide which have the deleterious effects on tooth structures. The
      main problem which is usually experienced by the patients with the vital tooth bleaching is
      dentine hypersensitivity. Methods: Considering the inclusion and exclusion criteria 90
      patients will be selected at the OPD of Dow University of Health Sciences Ojha campus with
      mild to moderate discoloration and randomly divided in to three groups group A control group
      (fluoride varnish) group B Propolis and group C Propolis mixed with bleaching agent. After
      performing the bleaching procedure respective desensitizing agent was applied to each group
      for 10 minutes. Visual analogue scale and Schiff's scale were used to assess the sensitivity
      after completion of treatment. Subjective non stimulated assessment of sensitivity was done
      by using the visual analogue scale from day 1 till day 7 on given Performa and Objective
      stimulated assessment of sensitivity was done at the dental office on day 1 right after the
      procedure and at day 7 on follow-up after one week.

      Statistical analysis was carried out by using the software SPSS IBM version 26.Median and
      inter quartile range (IQR) were reported to describe continuous variables (pain and
      sensitivity score) Normality of continuous variable (VAS pain score and sensitivity score)
      was checked by using the Shapiro-wilk test and Kruskal-Wallis test was applied to check
      median pain score and sensitivity difference between the groups. Mann-Whitney U test was
      applied to check further pairwise comparison between the groups. Chi-squire test was applied
      and cross tabulation done to see the association between all groups and visual analog scale.
      P-values of less than or equal to ≤ 0.05 were used to determine the significance of all test
      results.
    

Intervention name(s): Propolis; hydrogen peroxide 35%; fluoride varnish
Intervention type(s): Drug; Drug; Other
Intervention description(s): Vital tooth bleaching will be performed and Propolis as a desensitizing agent will be applied after bleaching to reduce dentine hypersensitivity.; hydrogen peroxide 35%; fluoride varnish
Intervention MeSH terms: Hydrogen Peroxide; Propolis; Fluorides; Fluorides, Topical
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Subjects are randomly placed into one of the groups: Control, Propolis and Propolis mixed with bleaching agent. In Propolis group Propolis paste will be applied for 10 minutes. Post operative sensitivity will be assessed for 7 days by using visual analogue and Shiff's scale.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Tooth discoloration, vital tooth bleaching, dentine hypersensitivity, desensitizing agent, Propolis; Vital tooth bleaching