Comparing Autologous Blood, Corticosteroid, and Their Combined Injection for Treating Lateral Epicondylitis
Condition: Lateral Epicondylitis; Comparing Autologous Blood Corticosteroid and Their Combined Injection for Treating Lateral Epicondylitis
MeSH terms: Tennis Elbow
Study type: Interventional

Summary: 
      The goal of this clinical trial is to compare autologous blood, corticosteroid, and their
      combined injection for treating lateral epicondylitis. The main question it aims to answer
      are:

      • Which of these highly used drugs in treatment of lateral epicondylitis is more effective?
      Participants were randomly allocated into three equal treatment groups (AB versus CS versus
      their combination) with sealed envelopes prepared by a computer-based random number
      generator. Patients in the AB Group received 1 ml of autologous venous blood mixed with 2 ml
      of 2% prilocaine HCl, patients in the CS Group received 1 ml of 40 mg methylprednisolone
      acetate mixed with 2 ml of 2% prilocaine HCl, and patients in the Combined Group (AB+CS)
      received 1 ml of autologous venous blood, 1 ml of 40 mg methylprednisolone acetate mixed with
      1 ml of 2% prilocaine HCl. Each group received an equal amount of (3 ml) injected material.
      PRTEE and HGS measurements were assessed before the injection (baseline values), on Day 15,
      Day 30, and Day 90, in the same manner by the senior author.
    

Detailed description: 
      This study aimed to compare the efficacy of autologous blood (AB) and corticosteroid (CS)
      injections and their combination in treating lateral epicondylitis (LE), hypothesizing that
      the combined approach might offer immediate symptom resolution and lower recurrence. Methods:
      A total of 120 patients diagnosed with lateral epicondylitis were systematically distributed
      among three distinct therapeutic injection groups. Those in the AB group were administered
      1ml of autologous venous blood mixed with 2ml of 2% prilocaine HCl. Participants in the CS
      category were given 1ml of 40 mg methylprednisolone acetate mixed with 2ml of 2% prilocaine
      HCl. Meanwhile, patients in the combined group received a mixture containing 1ml each of
      autologous venous blood and 40mg methylprednisolone acetate, along with 1ml of 2% prilocaine
      HCl. Prior to receiving their respective injections, a comprehensive assessment of all
      participants was carried out. Follow-up assessments were subsequently conducted on days 15,
      30, and 90, utilizing metrics of patient-rated tennis elbow evaluation (PRTEE) and
      measurements of hand grip strength (HGS).
    

Intervention name(s): Corticosteroid; Autologous Blood; Local Anesthetic
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 1 ml of 40 mg methylprednisolone acetate; 1 ml of autologous venous blood; 1 ml of 2% prilocaine HCl
Intervention MeSH terms: Anesthetics; Anesthetics, Local
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A Randomized Clinical Trial
Masking: Single (Investigator)
Primary purpose: Health Services Research