bioihbjkbjnl/mcl2 huggingface dataset:
Comparative Evaluation of Osseodensification Versus Conventional Implant Site
Condition: Bone Density; Implant Stability
Study type: Interventional

Summary: 
      The present study is a human, prospective, randomised controlled clinical trial conducted to
      explore and compare the clinical and radiological outcome of Osseodensification protocol with
      conventional implant site preparation protocol. The trial is in accordance with the
      Consolidated Standards of Reporting Trials (CONSORT) criteria, 2010.
    

Detailed description: 
      Twenty two dental implants were placed in twelve healthy individuals satisfying the inclusion
      and exclusion criteria were recruited for the study. A detailed, thorough medical and dental
      history was obtained and each patient was subjected to comprehensive clinical and
      radiological examination. All patients were informed about the nature of the study, the
      surgical procedure involved, potential benefits and risks associated with the surgical
      procedure and written informed consent were obtained from all patients.

      All the patients received Norris implant. the implant site preparation technique being
      Osseodensification protocol for the test group and conventional implant site preparation
      protocol for the control group, eleven in each group. The clinical and radiographic
      parameters were recorded at baseline, immediate post implant placement, six months and twelve
      months postoperatively.
    

Intervention name(s): osseodensification protocol; conventional implant site preparation protocol
Intervention type(s): Procedure; Procedure
Intervention description(s): Local anaesthesia was administered and mucoperiosteal flap was reflected. Implant osteotomies was performed with sequential drilling with osseodensification protocol at 1100 rpm. The pilot drill was used in clockwise direction and the other sequential drills were used in counter clockwise direction under copious irrigation. Flap closure was achieved using 3-0 silk sutures to protect the implant site.; Local anaesthesia was administered and mucoperiosteal flap was reflected. Implant osteotomies was performed with sequential drilling with conventional implant site preparation protocol at 1100 rpm. The pilot drill was used in clockwise direction and the other sequential drills were used in clockwise direction under copious irrigation. Flap closure was achieved using 3-0 silk sutures to protect the implant site.
Other intervention name(s): Densah bur protocol; Osseodensification technique; standard drilling technique, regular drilling technique
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: wo groups were made one test and control. The control group were treated with conventional implant site preparation technique and the test group were treated with osseodensification technique.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: hounsfield
A Trial on Metacognitive Training for Depression (D-MCT)
Condition: Depression
MeSH terms: Depression; Depressive Disorder
Study type: Interventional

Summary: 
      The purpose of the present randomized-controlled trial is to investigate the efficacy of
      Metacognitive Training for Depression (D-MCT), a new low-threshold, modular group
      intervention.
    

Detailed description: 
      Despite the existence of evidence-based treatment methods, a significant treatment gap
      remains for major depression. While in acute psychiatric treatment of severely depressed
      patients a pharmacological treatment is usually applied, depression-specific
      psychotherapeutic (group) concepts are rarely part of the treatment, though recommended in
      clinical guidelines. A main reason is that present group concepts were designed primarily for
      outpatient settings and do not meet the structural requirements of inpatient care (i.e.,
      short residence time, continuous admissions and dismissals).

      Metacognitive Training for Depression (D-MCT) is a new low-threshold, modular group
      intervention which was designed to fill this treatment gap by addressing contextual and
      structural shortcomings of existing concepts for the use in inpatient treatment. The training
      targets depressive symptoms by changing (meta-) cognitive biases identified in both cognitive
      models of depression and basic research. D-MCT was positively evaluated with regard to
      feasibility and acceptance in a non-randomized pilot study.

      Aim of the present randomized-controlled trial is to investigate the efficacy of D-MCT as an
      add-on intervention in inpatient treatment of depressed patients compared with a standard
      add-on group therapy (Positivity Training, PT). Based on a power analysis, the investigators
      target a sample size of 60 depressed patients, who will be randomized either to D-MCT or PT.
      Blind to diagnostic status, symptom level as well as cognitive biases will be assessed pre-
      and post-treatment (8 group sessions) as well as 3 months later (follow-up). Primary outcome
      parameter is severity of depressive symptoms measured with the HDRS total score (17-item
      version). Secondary outcome measures are self-assessed depression (BDI), dysfunctional
      beliefs (DAS), metacognitions (MCQ), self-esteem (RSE), and quality of life (WHOQOL-BREF).
    

Intervention name(s): Metacognitive Training; Positivity Training
Intervention type(s): Other; Other
Intervention description(s): 8 group sessions á 60 min; 8 group sessions á 60 min
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Psychotherapy, Group; Metacognition; Cognitive Bias
Glucose Homeostasis Pre and Post Bariatric Surgery
Condition: Morbid Obesity
MeSH terms: Obesity, Morbid
Study type: Observational

Summary: 
      The investigators wish to study the effects of three forms of bariatric surgery: Roux-en-Y
      gastric bypass, Sleeve Gastrectomy, and Gastric Banding. The surgery is not part of the
      clinical trial. If your insurance does not cover the procedure, then you are responsible for
      payment of the surgical process. We are doing pre and post surgery testing to provide a
      better understanding of the effect of bariatric surgery-induced weight loss on metabolic
      function.
    

Detailed description: 
      Bariatric surgery is the most effective weight loss therapy for obesity. Moreover, the early
      improvement in insulin sensitivity and the resolution of type 2 diabetes after bariatric
      surgery has led to the hypothesis that bariatric surgery has specific beneficial effects on
      glucose homeostasis beyond weight loss alone. However, this hypothesis has never been
      adequately evaluated in human subjects. Therefore, the primary goal of this proposal is to
      provide a better understanding of the effect of bariatric surgery-induced weight loss on
      insulin action and pancreatic beta cell function.
    

Intervention name(s): gastric bypass; gastric banding; sleeve gastrectomy
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): Roux-en-Y gastric bypass; laparoscopic adjustable gastric banding; vertical sleeve gastrectomy
Other intervention name(s): Roux-en-Y gastric bypass; lap band; gastric sleeve
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        A total of 20 (per surgical group) morbidly obese (BMI ≥ 35 kg/m²) subjects scheduled for
        bariatric surgical procedures will participate in this study.
      
Biospecimen description: 
      plasma, tongue tissue, muscle tissue, fat tissue,liver tissue, colon tissue, stool
    
Keywords: obesity; gastric bypass; gastric banding; weight loss; insulin sensitivity; sleeve gastrectomy; fibroblast growth factor 21; fibroblast growth factor 19
Injection Technique in Subacromial Impingement Syndrome
Condition: Subacromial Impingement Syndrome
MeSH terms: Shoulder Impingement Syndrome; Syndrome; Rotator Cuff Injuries
Study type: Observational

Summary: 
      Since pain is usually accompanied by a substantial effect on daily life that results in the
      extensive use of healthcare resources. In subacromial impingement syndrome, shoulder pain
      affects the quality of life negatively by affecting upper extremity functions and
      interrupting night sleep. It is very important to control the pain in order to reduce the
      loss to the labor force and prevent the pain from becoming chronic. Various physical
      treatment methods such as ultrasound, hot pack, transcutaneous electrical nerve stimulation,
      etc., and injections or medical agents are recommended. This study aimed to compare the
      effects of ultrasound (US)-guided in comparison to landmark guided subacromial
      corticosteroids injection on shoulder range of motion (ROM), pain, and functional status in
      patients with subacromial impingement syndrome (SAIS).
    

Detailed description: 
      Patients were assigned to two groups: Group-1 included patients who received US-guided
      subacromial corticosteroid injections; Group-2 included patients who underwent blind
      subacromial corticosteroid injections. The primary Outcome Measure was a Visual analog scale.
      Secondary Outcome Measures were Shoulder joint range of motion (ROM), Shoulder Pain and
      Disability Index (SPADI), The Shortened Disabilities of the Arm, Shoulder and Hand
      Questionnaire (Quick DASH).
    

Intervention name(s): subacromial corticosteroid injections
Intervention type(s): Other
Intervention description(s): Patients with SAIS whose application of corticosteroid in their injections were the same in terms of type and dose (1 ml betamethasone dipropionate + betamethasone sodium phosphate).
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Patients with the diagnosis of Subacromial impingement syndrome who underwent subacromial
        corticosteroid injections in our interventional physiatry clinic between September 2017 and
        February 2018 were included in this study.
Evaluation of Group Health Teaching With Video in Diabetic Patients
Condition: Diabetes Mellitus
Study type: Interventional

Summary: 
      Objective:Health videos and group education to allow patients to a correct understanding of
      diabetes and insulin treatment.

      Method:

      Standards and number of patients: The patients received subcutaneous insulin injection,
      estimated 30 people enrolled.

      Experimental Design and Methods:

        1. Screening out-patient treatment with insulin use, HbA1c> 8% or poor postprandial glucose
           (PPG)

        2. At the time of the visits, invite the patient to participate in the Video group
           education on insulin therapy By answering some questions about insulin injections, such
           as: do not know how to perform; afraid of the pain; fear of inconvenience, give patients
           time to complete the questionnaire.
    

Detailed description: 
      Diabetes is a long-term chronic disease. The patients need to correct "knowledge and action"
      lifestyle in order to achieve effective blood glucose control. Upon the general control of
      diabetic patients in Taiwan, however, glycosylated hemoglobin (HbA1c) is not satisfactory.
      One of the important reasons is the low rate of insulin injection. For the use of insulin,
      the patient has many misconception. The patients in the clinic need to spend a lot of time to
      explain and description, but the results are not necessarily good. So we hope that in this
      part of the health education activities through organized groups Videos to assist doctors and
      patients as a bridge of communication, to enhance diabetes doctor thus contributing to
      glycemic control results.
    

Intervention name(s): Video
Intervention type(s): Behavioral
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Incidence of Various Types of Systemic Reactions Related to Spinal Steroid Injection: A Prospective Study
Condition: Incidence and Types of Systemic Reactions Occurring After Spinal Steroid Injection in a Large Population
Study type: Observational [Patient Registry]

Summary: 
      Many systemic reactions occur commonly after spinal steroid injections, especially in
      patients, and may be associated with underlying disease, such as hypertension and diabetes
      mellitus, as well as steroid dose and repetition of spinal steroid injection.
    

Detailed description: 
      Evaluate the incidence and types of systemic reactions after spinal steroid injections and to
      investigate the association of spinal steroid injection with patient demographics, history of
      previous injections, type and dose of steroid, and method and site of previous and current
      injections.
    

Intervention name(s): Spinal Steroid Injection
Intervention type(s): Drug
Intervention description(s): Steroid Injection
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        All patients receiving the injection were informed of the aim and protocol of this study
        and the possible local and systemic reactions associated with spinal steroid injection
      
Keywords: Spinal injection; Steroid; Systemic reaction; Complication; Side effect; Diabetes mellitus; Hypertension; Risk factor
A Drug Interaction Study of Cilnidipine and Valsartan
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The investigators investigate the potential pharmacokinetic drug-drug interaction between
      Cilnidipine 10 mg and Valsartan 160 mg in healthy male volunteers who receive Cilnidipine 10
      mg alone, Valsartan 160 mg , and both together in a 3 period repeatedly.
    

Detailed description: 
      To evaluate the safety, drug-tolerance, pharmacokinetics of Cilnidipine 10 mg or Valsartan
      160 mg monotherapy or Cilnidipine 10 mg and Valsartan 160 mg combination in healthy male
      subjects.
    

Intervention name(s): C - V - C+V; C - C+V - V; V - C - C+V; V - C+V - C; C+V - C - V; C+V - V - C
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Drug will be administered to according to C - V - C+V sequence for 3 period.; Drug will be administered to according to C - C+V - V sequence for 3 period.; Drug will be administered to according to V - C - C+V sequence for 3 period.; Drug will be administered to according to V - C+V - C sequence for 3 period.; Drug will be administered to according to C+V - C - V sequence for 3 period.; Drug will be administered to according to C+V - V - C sequence for 3 period.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: cilnidipin and valsartn; pharmacokinetic drug drug interaction; oral administration; healthy male subjects
Safety and Efficacy of a Flavonoids- and omega3s-based Compound for the Treatment of Muscular Dystrophies
Condition: Muscular Dystrophies; Muscle Inflammation
MeSH terms: Muscular Dystrophies; Myositis; Inflammation
Study type: Interventional

Summary: 
      The study aimed to assess the safety and, partially, the efficacy of dietary supplementation
      of a flavonoids-, DHA- and EPA-based natural supplement in non-ambulant DMD boys and in a
      cohort of LGMD and FSHD patients to compare its effect in MDs of different aetiology and to
      eventually highlight any differences in inflammatory involved pathways. To assess safety,
      patient's laboratory parameters were monitored and adverse events recorded, while efficacy
      was evaluated through performance scale questionnaire and strength measurement (6 minute
      walking test and Biodex System 4 Dynamometer parameter evaluation). This study was conceived
      as proof of principle for the safe use of flavonoids/omega3s-based compound as an adjuvant in
      the management of neuromuscular disorders; besides, its efficacy in alleviating symptoms
      linked to secondary effects of genetic mutation as inflammation, muscular pain and weakness
      was assessed.
    


Intervention name(s): Flavonoids, DHA, EPA; placebo compound
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): oral administration; oral administration
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: dietary supplementation; flavonoids; omega 3
Evaluation of the Effectiveness of a Continuing Education Program in Community Pharmacies
Condition: Controlled Drug Dependence
MeSH terms: Substance-Related Disorders
Study type: Interventional

Summary: 
      Preventable failures in the drug chain are related to Drugs Problems Related Use and are
      associated with medication errors (prescription, dispensing, administration or use by the
      patient or caregiver), including failures In the Medication Supply System (availability and
      quality).

      The controlled drugs are those that contain substances regulated by international conventions
      on drug control. They are important in various fields of medicine, such as pain management,
      obstetric emergencies, mental disorders such as the treatment of substance dependence,
      psychiatry and neurology. It has been defined as abuse of drugs the improper use of these for
      non-medical purposes, and associated with the use without medical prescription, which can
      produce addiction or psychic or physical dependence.
    

Detailed description: 
      Experimental study with random assignment of the staff pharmacist of Pharmacies. The staff
      pharmacists admitted will be followed for 12 months (1 year). The study will make it possible
      to determine the effect of the continuing education program accompanied by Information and
      Communication Technologies (ICT).
    

Intervention name(s): Staff pharmacy whith intervention
Intervention type(s): Other
Intervention description(s): Pharmacists who will receive continuous education through technology and communication tools, as well as accompaniment and advice from a pharmaceutical chemist
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: study protocol for a multicenter, cluster-randomized controlled trial.
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Dispensation; Health Education; Pharmacovigilance; Pharmacists
Serum Endostatin Type 2 Diabetic Patients
Condition: Diabetes Mellitus, Type 2; Coronary Artery Disease; Coronary Arteriosclerosis
MeSH terms: Coronary Artery Disease; Myocardial Ischemia; Arteriosclerosis; Diabetes Mellitus, Type 2
Study type: Observational

Summary: 
      To assess the relationship between serum endostatin (ES) and Coronary artery calcification
      (CAC) in type 2 diabetic (T2DM) patients.
    

Detailed description: 
      elevated serum endostatin levels were independently associated with increased risk, severity
      and progression of coronary artery calcification independent of traditional cardiovascular
      disease risk factors in T2DM subjects with known coronary artery disease. So, Measurement of
      serum ES levels can improve the diagnosis of coronary artery calcification and could be
      useful as a high sensitive marker for the presence and progression of atherosclerosis in T2DM
      patients.
    

Intervention name(s): serum endostatin level
Intervention type(s): Diagnostic Test
Intervention description(s): An oral (metoprolol 20 mg) was given to the patients with heart rates > 60 beats/minute and had no contraindications to beta-blockers, one hour before the scan. Sublingual nitroglycerin was given to all patients before CT examination. A 64-slice CT scanner (Sensation 64; Siemens Medical System, Germany) was used for imaging all subjects. All CT examinations were done during inspiratory breath holding.
Endostatin levels were measured using a sandwich ELISA kit according to the manufacturer's instructions endostatin ELISA kit (R&D Systems, Minneapolis, Minnesota, USA
Other intervention name(s): Computed tomography
Intervention MeSH terms: Endostatins
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        One hundred ten out documented CAD subjects were divided into two groups; group I
        (Fifty-five CAD patients without T2DM) and group II (Fifty-five CAD patients with T2DM)
        addmitted to Zagazig University hospital. Egypt
Luteal Phase Support in Insemination Cycles
Condition: Infertility, Female
MeSH terms: Infertility; Infertility, Female
Study type: Interventional
Phase: Phase 4

Summary: 
      This study is a prospective randomized trial with 242 IUI cycles. Patients are randomized in
      two groups including 121 cycles in each group. A total of 255 cycles in 167 patients are
      finally recruited. In the first group, the patients will be treated with triptorelin
      (Gonapeptyl®) in their luteal phase. As for the other group, the patients will undergo the
      luteal phase without any supportive medication. This study is going to clarify the role of
      the gonadotropin agonist (triptorelin acetate, Gonapeptyl®) as a luteal phase supporter. The
      benefit of the treatment is measured by the numbers in the live birth and clinical pregnancy
      rates.
    


Intervention name(s): Triptorelin
Intervention type(s): Drug
Intervention description(s): Triptorelin 0,1mg/ml subcutaneously once in a luteal phase in insemination cycles.
Intervention MeSH terms: Triptorelin Pamoate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Insemination; Luteal phase support; Gonadotropin-releasing hormone agonist; Triptorelin
Feeding the Rainbow to Investigate Endothelial Dysfunction
Condition: Dietary Modification; Cardiovascular Disease
MeSH terms: Cardiovascular Diseases
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The primary purpose of this study is to compare the change in blood carotene concentration
      between a food-based versus nutritional supplement-based intervention. This study will
      randomize up to 60 healthy volunteers to receive either carotenoid-enriched food; natural,
      mixed carotenoid supplementation; chlorophyll complex or placebo supplementation. Blood
      carotene levels will be measured before and after 28 days of supplementation. Preliminary
      data will also be collected on several biomarkers associated with vascular inflammation and
      endothelial dysfunction. These biomarkers will be measured before and during a fast food
      control meal at the beginning and end of the intervention period.
    


Intervention name(s): Chlorophyll complex, Standard Process; Betatene, sold as "Full Spectrum Carotenoid Complex"; Small carotenoid-rich meals; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement; Other; Other
Intervention description(s): One capsule, twice daily with meals for 28 days; One capsule per day with meals for 28 days; Single carotenoid-enriched soup or salad serving eaten daily; Safflower oil-filled capsules, one twice daily with meals
Intervention MeSH terms: Carotenoids
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: mixed carotenes