bioihbjkbjnl/mcl2 huggingface dataset:
Prevalence of and Factors Associated With Metabolic Syndrome in Schizophrenia
Condition: Metabolic Syndrome; Quality of Life; Depression
MeSH terms: Metabolic Syndrome; Syndrome; Depression; Schizophrenia
Study type: Observational

Summary: 
      Patients with schizophrenia are more likely to have metabolic syndrome compared to general
      population. The criterion for metabolic syndrome in Asian people including: elevated waist
      circumference (male ≥ 90cm, female ≥ 80cm), elevated triglycerides ≥ 150mg/dL, reduced HDL
      cholesterol: male < 40mg/dL, female < 50mg/dL, elevated blood pressure: ≥ 130/85 mmHg,
      elevated fasting glucose: ≥ 100mg/dL. Several factors have been found to be associated with
      metabolic syndrome in schizophrenia, e.g. age, antipsychotic drugs, smoking, family history
      of metabolic disorder, stress, and quality of life.

      However, little is known about the prevalence of and factors associated in Asian. This study
      aimed to:

        1. Identify the prevalence of metabolic syndrome in patients with schizophrenia.

        2. Identify the factors associated with metabolic syndrome in patients with schizophrenia.
    

Detailed description: 
      Patients with schizophrenia are more likely to have metabolic syndrome compared to general
      population. The criterion for metabolic syndrome in Asian people including: elevated waist
      circumference (male ≥ 90cm, female ≥ 80cm), elevated triglycerides ≥ 150mg/dL, reduced HDL
      cholesterol: male < 40mg/dL, female < 50mg/dL, elevated blood pressure: ≥ 130/85 mmHg,
      elevated fasting glucose: ≥ 100mg/dL. Several factors have been found to be associated with
      metabolic syndrome in schizophrenia, e.g. age, antipsychotic drugs, smoking, family history
      of metabolic disorder, stress, and quality of life.

      However, little is known about the prevalence of and factors associated in Asian. This study
      aimed to:

        1. Identify the prevalence of metabolic syndrome in patients with schizophrenia.

        2. Identify the factors associated with metabolic syndrome in patients with schizophrenia.

      Method This study is a cross-sectional study conducting at the Faculty of Medicine, Chiang
      Mai University. Eighty participants will be recruited with the inclusion criteria of having
      diagnosed with schizophrenia according to DSM-IV-TR and aged 18 years or over. The exclusion
      criterion is having organic brain syndrome.

      Measurements PANSS CDSS WHOQOL-BREF-THAI
    

Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Participants diagnosed with schizophrenia
      
Keywords: Metabolic syndrome; Prevalence; Quality of life; Depression; Antipsychotics
Bioequivalency Study of Exemestane 25 mg Tablet Under Fasted Conditions
Condition: Breast Cancer
Study type: Interventional

Summary: 
      The objective of this study was to prove the bioequivalence of Exemestane 25 mg tablet under
      fasted conditions
    


Intervention name(s): exemestane
Intervention type(s): Drug
Intervention description(s): 25 mg tablet
Other intervention name(s): AROMASIN
Intervention MeSH terms: Exemestane
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Extracorporeal Shockwave Therapy vs Mesotherapy in the Treatment of Myofascial Pain Syndrome: a Case-control Study
Condition: Myofascial Pain Syndrome; Trigger Point Pain, Myofascial
MeSH terms: Myofascial Pain Syndromes; Fibromyalgia; Syndrome; Somatoform Disorders
Study type: Interventional

Summary: 
      Myofascial Pain Syndrome (MPS) is a disorder of the musculoskeletal system manifested by
      referred pain associated with functional limitation, muscle contractures, and possible
      neuralgic manifestations; this condition is characterized by the presence of "trigger
      points". The goal of this case-control study was to compare the effects and benefits of
      treatment with ESWT vs Mesotherapy in myofascial pain syndrome. The main question it aims to
      answer is: what is the best rehabilitation project-program between ESWT and mesotherapy for
      patients with myofascial syndrome? A case-control study was conducted at the U.O.C. of
      "Recovery and Functional Rehabilitation" A.O.U.P. "P. Giaccone" of Palermo from February 2022
      to Dicember2023. Patients were randomized into 2 groups: in group "A", No. 5 sessions of
      focal ESWT were given weekly; in group "B", No. 5 sessions of Mesotherapy with administration
      of Thiocolchicoside fl 4mg/2ml and Mepivacaine fl 10mg/1ml were given weekly. Patients in
      group "A" and group "B" were evaluated at baseline (T0), after 5 sessions (T1) and one month
      after the end of treatment (T2). Researchers will compare patients treated with ESWT and
      patients performing mesotherapy to see if there are real differences in terms of pain
      reduction and improved quality of life.
    


Intervention name(s): Extracorporeal Shockwave Therapy (Group A); Mesotherapy (Group B)
Intervention type(s): Other; Other
Intervention description(s): Each patient was evaluated before treatment for trigger points; patients underwent focal ESWT (PulseWave 2 - Mectronic Medicale s.r.l.) with a specific program for muscle contractures and myofascial pain (80-100 mJ with 2250 pulses of 5-10 Hz).; Each patient was evaluated before treatment for trigger points; after disinfection with Chlorhexidine 2% and sterile gauze, Thiocolchicoside fl 4mg/2ml, and a local anesthetic, Mepivacaine fl 10mg/1ml, diluted in 0.9% NaCl saline, for a final volume of 10 ml, were inoculated mesodermally; 6 to 12 microinjections with needle 26G 0.40x4mm, were performed.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Muscle contracture; ESWT; Mesotherapy; Myofascial syndrome; Trigger point
Effectiveness of Orally Dosed Emergency Contraception in Obese Women - LNG
Condition: Obesity
MeSH terms: Emergencies
Study type: Interventional
Phase: Phase 4

Summary: 
      Obese women are significantly more likely than their normal BMI counterparts to experience
      failure of orally-dosed emergency contraceptives. The PI's preliminary data provides evidence
      for testing a dose escalation strategy in an effort to provide improved efficacy from
      orally-dosed emergency contraceptives in obese women. The overall project will be focused on
      both levonorgestrel (LNG) - and ulipristal acetate-containing emergency contraception but
      this protocol registration is for the LNG aspect of the study procedures.
    

Detailed description: 
      Emergency contraception (EC) provides a woman with an additional line of defense against
      unintended pregnancy following an act of unprotected intercourse. Orally-dosed EC works by
      delaying ovulation and reduces the risk of pregnancy for a single act of unprotected
      intercourse by 50-70%. Unfortunately, obese women are significantly more likely than their
      normal BMI counterparts to experience failure of orally-dosed EC and in some instances EC is
      equivalent to placebo.

      The PI's preliminary data provides evidence for testing a dose escalation strategy in an
      effort to provide improved efficacy from orally-dosed EC in obese women. The hypothesis is
      that increasing the dose of orally-dosed EC agents will normalize the pharmacokinetics
      resulting in the expected treatment effect (delay in follicle rupture) in obese women. In the
      overall proposal, the investigators plan to perform detailed pharmacokinetic and
      pharmacodynamic studies of ulipristal acetate-based EC in obese women and expand upon the
      preliminary findings of levonorgestrel-based EC. This protocol registration is for the LNG
      aspect of the study procedures focused on the pharmacodynamics of LNG dose escalation
    

Intervention name(s): Levonorgestrel-based emergency contraception 1.5 mg; Levonorgestrel-based emergency contraception 3.0mg
Intervention type(s): Drug; Drug
Intervention description(s): Evaluating pharmacodynamic outcomes in obese women using 1.5mg versus 3.0mg of LNG-based EC; Evaluating pharmacodynamic outcomes in obese women using 1.5mg versus 3.0mg of LNG-based EC
Other intervention name(s): Plan B; Next Choice
Intervention MeSH terms: Levonorgestrel
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Obesity; Body weight; Emergency contraception; Levonogestrel; Ulipristal acetate
Simultaneous Lengthening of Bilateral Femora and Tibiae in Achondroplastic Patients
Condition: SHOX Gene With Short Stature
MeSH terms: Dwarfism
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether lengthening of both the tibiae and femora
      in achondroplastic patients is safe and provides reproducible outcome.
    


Intervention name(s): Lengthening over nail
Intervention type(s): Procedure
Intervention description(s): External fixator is used to lengthen either the femur or the tibia over an intramedullary nail
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Lengthening
3 Days Amoxicillin Versus Placebo for Fast Breathing Childhood Pneumonia in Malawi
Condition: Pneumonia
MeSH terms: Pneumonia
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study to assess the effectiveness of no antibiotic treatment for fast
      breathing, community-acquired childhood pneumonia in a malaria-endemic region of Malawi.
    


Intervention name(s): Amoxicillin; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Oral amoxicillin dispersible tablets (DT), 250 mg tablets, given according to age band, two times daily; Oral placebo dispersible tablets (DT), 250 mg tablets, given according to age band, two times daily
Intervention MeSH terms: Amoxicillin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Effect of Warm Water Footbaths With Added Ginger or Mustard Powder on Psychosocial Parameters in Patients With an Oncological Disease
Condition: Oncologic Disorders
Study type: Interventional

Summary: 
      A randomized, controlled, three-arm trial to investigate the effects of warm water footbaths
      with and without the addition of ginger or mustard powder on psychosocial parameters in
      patients with an oncological disease and in healthy controls.
    

Detailed description: 
      A randomized, controlled trial with cross-over design in which the subjects (23 patients with
      an oncological disease, 13 healthy controls) receive warm water footbaths with added ginger
      (experimental) or mustard powder (experimental) or without additives (active comparator). The
      wash-out period between two consecutive footbath interventions is at least one day. Outcome
      measures are assessed right before (t1), right after (t2) and 10 minutes following the
      footbath (t3). The main focus is on the change in subjective perception of warmth
      distribution between t1 and t3. Moreover, the objective skin temperature distribution and
      psychosocial scores are assessed. The primary outcome measure is analyzed with a linear mixed
      effects model (after checking for carry-over effects). Secondary outcome measures are
      described descriptively.
    

Intervention name(s): Ginger powder footbaths; Mustard powder footbaths; Warm water only footbaths
Intervention type(s): Other; Other; Other
Intervention description(s): 20-minute footbath with 12 liters of 40°C warm water and an additive of 80g dried ginger powder (reaching up to mid-calf level); 20-minute footbath with 12 liters of 40° C warm water and an additive of 80g dried mustard powder (reaching up to mid-calf level); 20-minute footbath with 12 liters of 40° C warm water without any additive (reaching up to mid-calf level)
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Each participant receives all three footbath interventions (warm water only=WA, with added ginger powder=GI, with added mustard powder=MU) in a randomized order stratified by gender. For this, participants are randomly allocated to one of six possible footbath sequences (a: MU-WA-GI, b: MU-GI-WA, c: WA-GI-MU, d: WA-MU-GI, e: GI-MU-WA, f: GI-WA-MU). For the main analysis, groups are pooled together with regard to the intervention received (WA vs. MU vs. GI) after checking for potential carry-over effects.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Ginger; Mustard; Footbath; Warmth perception; Infrared thermography; Healthy volunteers
Brain Electrophysiological Patterns in Obesity
Condition: Obesity
MeSH terms: Obesity
Study type: Observational

Summary: 
      There is growing evidence of behavioural and neurobiological overlaps between obesity and
      drug abuse. Reduction of the amplitude of P300, a component of event-related potentials (ERP)
      elicited by an oddball paradigm, is an electrophysiological characteristic and a marker of
      vulnerability in substance abuse. We want to determine whether obesity is associated with
      such electrophysiological features during an auditory oddball paradigm. We postulate that
      obesity could be associated with electrophysiological abnormalities that could be viewed as a
      possible vulnerability marker for food addiction.
    


Observational model: Case-Control
Sampling method: Non-Probability Sample
Study population: 
        a healthy but normal-weighted or obese population. Depressive state or eating disorders
        were carefully evaluated.
      
Keywords: obesity; cognitive process; reward; P300; ERP; Event-related potential during oddball paradigm; brain electrophysiological patterns; externalizing factor
Investigation of the Acute Effects of Percussive Massage Treatment and Stretching Exercise on Balance and Performance
Condition: Sports Physical Therapy
Study type: Interventional

Summary: 
      In this study, it was aimed to investigate the acute effects of Percussion Massage Therapy
      and stretching exercises on balance, horizontal jumping and performance in healthy
      individuals. It was planned to include 45 individuals in the study. Participants will be
      randomly divided into 3 groups. Horizontal jumping distance, T-Drill test and balance
      assessment will be done for all participants. After the evaluation, percussion massage
      therapy will be given to the 1st group, dynamic stretching exercises to the 2nd group, and
      static stretching exercises to the 3rd group. All measurements will be repeated after the
      intervention.
    

Detailed description: 
      48 healthy individuals meeting the inclusion criteria of Istanbul Medipol University will be
      included in the study. Individuals who are at a level to perform performance tests, who have
      not undergone orthopedic surgery in any of their regions, who do not have problems in running
      and during sudden turns, and who do not have a professional sports background will be
      included in the study. Individuals with a history of trauma, anatomical deformities and
      skeletal system fractures, diagnosed orthopedic or rheumatological diseases, being included
      in the physiotherapy program in the last 6 months, and those with pain in any region will be
      excluded from the study. Before the study, demographic information, horizontal jump test,
      T-Test and Fizyosoft balance system will be evaluated with both feet and one foot with eyes
      open and closed. After the evaluation, percussion massage therapy will be given to the 1st
      group, dynamic stretching exercises to the 2nd group, and static stretching exercises to the
      3rd group. All measurements will be repeated after the intervention.
    

Intervention name(s): Percussive Massage Group; Dynamic stretching group; Static stretching group
Intervention type(s): Other; Other; Other
Intervention description(s): Quadriceps, hamstring and gastrocnemius muscles of the participants will done massage for 3 minutes with a hypervolt massage device.; Dynamic stretching will be performed for the quadriceps, hamstring and gastrocnemius muscles of the participants with 10 repetitions.; Static stretching will be performed for the quadriceps, hamstring and gastrocnemius muscles of the participants with 10 repetitions.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: percussion massage therapy; dynamic stretching; static stretching
Phase I Safety and Immunogenicity Study of VAX102 [Flagellin.HuM2e] Influenza Vaccine in Healthy Adults
Condition: Influenza Infection
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will evaluate the safety and immunogenicity of VAX102 [Flagellin.HuM2e], a
      recombinant, inactivated, subunit influenza vaccine given as a two dose regimen at a range of
      doses.
    

Detailed description: 
      VAX102 is a cross-protective influenza A vaccine based on a recombinant protein expressed in
      E. coli. The protein comprises Salmonella typhimurium flagellin type 2 (STF2; TLR5 ligand)
      fused to Human M2e. The active component of the VAX102 vaccine is manufactured by a standard
      fermentation process. Unlike the HA and NA viral proteins, the amino acid sequence of M2e has
      remained remarkably stable in all human influenza A virus isolates. Thus an influenza vaccine
      based on the M2e antigen could elicit cross-protective immunity against most human influenza
      A virus strains. VAX102 vaccine relies on a single cross-reactive influenza A virus antigen
      manufactured by a recombinant protein fermentation-production process.
    

Intervention name(s): VAX102 [Flagellin.HuM2e]; Placebo
Intervention type(s): Biological; Biological
Intervention description(s): dose ranging, 2 i.m. doses given 28 days apart; Placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Influenza vaccines; M2e
The Impact of an Immersive Digital Therapeutic Tool on Pain Perception
Condition: Pain Perception
Study type: Interventional

Summary: 
      The goal of this experimental study is to examine the impact of a virtual reality paradigm on
      heat pain perception in healthy volunteers. The main question it aims to answer is to
      determine if the virtual reality paradigm reduces pain intensity and unpleasantness evoked by
      tonic heat pain stimulation. Tonic heat pain stimulation is applied on the left forearm of
      participants using a Peltier thermode immediately before, during and immediately after
      virtual reality exposure. Using a with-subject design, participants are sequentially exposed
      to both the virtual reality condition and an active control condition. The order of
      administration of the virtual reality and control conditions is randomized.
    

Detailed description: 
      Pain is a complex and multifaced sensory and emotional experience. Virtual reality has shown
      promise in reducing experimental pain and chronic pain. However, many previous trials in the
      field lacked proper control conditions. This experimental study examines an immersive virtual
      environment initially designed for the treatment of endometriosis patients, which
      demonstrated promising analgesic effects. The current study aims to determine the impact of
      the virtual reality paradigm on experimental pain perception both during and after virtual
      reality exposure, while using an active control condition. This study involves healthy
      individuals with no chronic pain and uses a within-subject design, comparing a virtual
      reality paradigm with an active control condition. Continuous heat pain stimulation is
      applied to the left forearm of participants with a Peltier thermode, before, during and
      immediately after virtual reality exposure. For each continuous heat pain stimulation, pain
      intensity and unpleasantness are measured using a scale from 0 (no pain) to 100 (worst pain).
      Using a with-subject design, participants are sequentially exposed to both the virtual
      reality condition and an active control condition. The order of administration of the virtual
      reality and control conditions is randomized. Both conditions are administered in a single
      experimental session at the laboratory.
    

Intervention name(s): Endocare
Intervention type(s): Other
Intervention description(s): Virtual paradigm (calming environnement)
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: Pain; Emotions; virtual reality; within-subject design
Asthma Comparative Effectiveness Study
Condition: Asthma
MeSH terms: Asthma
Study type: Observational

Summary: 
      The objective of this study is to compare the real-world effectiveness of BFC and FSC in
      asthma patients new to ICS/LABA combination therapy in a population of U.S. health plan
      enrollees.
    

Detailed description: 
      A U.S. retrospective database analysis evaluating the comparative effectiveness of
      budesonide/formoterol and fluticasone propionate/salmeterol among asthma patients
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Health plan members with asthma aged 12 to 64 years receiving two or more prescriptions for
        BFC or FSC during 6/1/2007-9/30/2010 who are naive to ICS/LABA combination therapy.
      
Keywords: Asthma; Comparative Effectiveness; Symbicort