bioihbjkbjnl/mcl2 huggingface dataset:
Predictive Value of Inflammatory Indexes and CHA2DS2-VASc Score for LVT in ANT-MI With Left Ventricular Dysfunction
Condition: Left Ventricular Thrombus; Acute Anterior Myocardial Infarction; Left Ventricular Dysfunction
MeSH terms: Myocardial Infarction; Thrombosis; Ventricular Dysfunction; Ventricular Dysfunction, Left; Anterior Wall Myocardial Infarction; Infarction
Study type: Observational

Summary: 
      To investigate the predictive value of inflammatory indexes and CHA2DS2-VASc score for
      anterior myocardial infarction (ANT-MI) with left ventricular thrombus(LVT) (LVT).
    

Detailed description: 
      The clinical data were collected from 371consecutive patients with ANT-MI in our hospital
      from January 2014 to January 2021.As a result,totally 62 patients with LVT were selected as
      the experimental group and 186 patients with non-LVT as the control group .The observation
      indexes included baseline data, coronary angiography, disease course, laboratory examination
      and auxiliary examination.Patients with severe organic disease and having previous history of
      left ventricular aneurysm( LVA) and LVT were excluded.Data was analyzed by software SPSS 22.0
      for statistical analysis,and the logistic regression model was established.A P<0.05 was
      considered statistically significant, and the risk factors of LVT formation were
      retrospectively analyzed.
    

Intervention name(s): inflammatory indexes and CHA2DS2-VASc score
Intervention type(s): Other
Intervention description(s): inflammatory indexes and CHA2DS2-VASc score
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        The study included a total of 371 patients with anterior myocardial infarction (ANT-MI)
        treated with emergency prior percutaneous coronary intervention (pPCI) in our hospital
        betweenfrom January 2014 andto January 2021. Patients were eligible for enrollmentenrolment
        if they had a reduced left ventricularLV ejection fraction (LVEF) ( ≤40%). and if detailed
        data on demographic and clinical characteristics were documented. Exclusion criteria were
        end-stage organic disease, thrombotic hematological disorders, previous anticoagulant use,
        and poor echogenicity (Figure 1). Based on the study criteria, 123 patients were excluded
        from the study; thus, 248 patients were included in the analysis.
      
Biospecimen description: 
      blood
    
Keywords: left ventricular thrombus;anterior myocardial infarction; Risk factors
Study of Combivir for Patients With Primary Biliary Cirrhosis
Condition: Primary Biliary Cirrhosis
MeSH terms: Liver Cirrhosis; Liver Cirrhosis, Biliary; Fibrosis
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      This is a proof of principal study to determine whether combination anti-viral therapy with
      Combivir impacts on hepatic biochemistry in patients with primary biliary cirrhosis
    

Detailed description: 
      A novel human retrovirus has been cloned from a cDNA library derived from biliary epithelia
      cells extracted from patients with Primary Biliary Cirrhosis. Although there is no formal
      proof that this virus is etiologically related to the disease, we have found evidence for
      viral infection in the majority of patients with PBC using standard serologic and
      hybridization assays. In order to address the hypotheses that PBC is etiologically related to
      a retrovirus infection and that anti-retroviral therapy may be beneficial for patients with
      PBC, we have conducted 2 pilot studies using lamivudine and Combivir (lamivudine 150mg and
      Zidovudine 300mg). On the whole, little clinical improvement was observed in patients on
      lamivudine therapy alone, whereas those on Combivir had significant reductions of hepatic
      biochemistry studies and histologic improvement. Moreover, 4 of 10 Combivir patients
      completely normalized their liver function tests and the anti-viral therapy was well
      tolerated. We now propose a larger randomized trial to assess the short term (6 months)
      safety and efficacy of Combivir for patients with PBC. Efficacy in this study will be defined
      using both liver biochemistries and virologic endpoints.
    

Intervention name(s): Combination antiviral therapy; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Zidovudine 300mg and lamivudine 150mg BID for 6 months; placebo BID for 6 months
Other intervention name(s): Combivir
Intervention MeSH terms: Antiviral Agents
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: primary biliary cirrhosis C06.552.630.400; retroviral infection C02.782.815
This Study is Done in Healthy Japanese Volunteers. It Looks at How Different Doses of BI 730357 Are Taken up in the Body and How Well They Are Tolerated
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The main objective of this trial is to investigate the safety and tolerability of BI 730357
      in Japanese healthy male subjects following oral administration of single rising doses.

      Secondary objectives are the explorations of the pharmacokinetic(s) (PK), including dose
      proportionality as well as investigation of linearity of BI 730357 after single dose
      administration.
    


Intervention name(s): BI 730357; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): single rising oral dose; single rising oral dose
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
A Drug Interaction Study Between Danicopan and Midazolam, Fexofenadine, and Mycophenolate Mofetil in Healthy Participants
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study was to determine the potential drug interaction between danicopan
      (ACH-0144471) and midazolam, fexofenadine, and mycophenolate mofetil. This was a 3-part
      study, with each part being an open-label, fixed-sequence, 2-treatment study in healthy adult
      participants.
    


Intervention name(s): Danicopan; Midazolam; Fexofenadine; Mycophenolate Mofetil
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Oral tablet.; Oral syrup.; Oral tablet.; Oral tablet.
Other intervention name(s): ALXN2040; ACH-0144471 (formerly); Midazolam HCl
Intervention MeSH terms: Fexofenadine; Mycophenolic Acid; Midazolam
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: Part 1, Part 2, and Part 3 could be conducted concurrently or separately, and the order of the parts could be determined according to the needs of the program.
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Danicopan; ALXN2040; ACH-0144471; Midazolam; Fexofenadine; Mycophenolate Mofetil; Drug Interaction; Pharmacokinetics; Factor D Inhibitor; Safety
Diagnosing Perineal Tears, Does Different Assessment Methods Affect the Midwife's Clinical Judgement of Perineal Tears?
Condition: Obstetric Perineal Rupture
MeSH terms: Rupture
Study type: Interventional

Summary: 
      This study aims to compare different midwife practitioners assessments of perineal tears.
    

Detailed description: 
      Perineal injuries are one of the traumas most frequently suffered by women during
      delivery.Countries report wide variations in trauma rates, and within countries further
      variations exists among institutions and also among professional groups of caregivers.Visual
      and digital examination of the wound has been and is the most common way to assess and
      classify a perineal tear. However resent studies indicate that many tears diagnosed with this
      method are misclassified.The suggested reasons for this, apart from the fact that bleeding
      and tissue oedema make the diagnose difficult, is that many healthcare providers have too
      little training in perineal assessment and basic anatomy.

      In this prospective randomised trial consenting women will be randomised in to the common
      visual and digital assessment of the perineal tear by to different midwives, blinded to each
      others assessment or visual and digital assessment and measuring of the tear with a small
      soft ruler, Peri-Rule also by two different midwives.
    

Intervention name(s): Objective measurements of perineal tears with "Peri-Rule"; Visual and digital assessment
Intervention type(s): Device; Other
Intervention description(s): Four measurements will be used in this study.
Depth of tear, from the fourchette into the greatest depth of the perineal body.
Length of tear, from the fourchette to the apex of the vaginal tear.
Length of tear, from the fourchette along perineal skin towards the anus.
Length of the perineal body, from the fourchette to outer margin of anus.; Midwifes assessing perineal tears as standard procedure with visual and digital examination of the perineal tear.
Other intervention name(s): Peri-Rule; Visual assessment; Digital assessment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: obstetric; perineal tear; perineal injury; diagnosis
Assessment of the Safety and Ability of a Once-a-day Dose of an Orally Inhaled Medicine [i.e., Glycopyrrolate Inhalation Solution = GIS] to Improve Airflow in the Lungs When Delivered Using an eFlow Nebulizer in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Condition: Chronic Obstructive Pulmonary Disease
MeSH terms: Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Study type: Interventional
Phase: Phase 2

Summary: 
      The study assessed the safety and ability of an orally inhaled medicine [i.e., Glycopyrrolate
      Inhalation Solution = GIS] to improve airflow in the lungs when delivered using an eFlow
      nebulizer in 42 patients with Chronic Obstructive Pulmonary Disease (COPD). Each patient
      randomly received several, single doses of GIS, or placebo, separated by approximately 1 to 2
      weeks. After the dose was given, lung airflow was measured over 24 hours and blood was
      collected to measure how much GIS was in the bloodstream. The study was conducted to find the
      once-a- day GIS dose that produced the highest improvement in lung airflow using the eFlow
      nebulizer.
    


Intervention name(s): Glycopyrrolate Inhalation Solution12.5μg; Glycopyrrolate Inhalation Solution 50μg; Glycopyrrolate Inhalation Solution 100μg; Glycopyrrolate Inhalation Solution 200μg; Glycopyrrolate Inhalation Solution 400μg; Placebo 0.5mL
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Glycopyrrolate Inhalation Solution12.5μg via eFlow, once daily; Glycopyrrolate Inhalation Solution 50μg via eFlow, once daily; Glycopyrrolate Inhalation Solution 100μg via eFlow, once daily; Glycopyrrolate Inhalation Solution 200μg via eFlow, once daily; Glycopyrrolate Inhalation Solution 400μg via eFlow, once daily; Placebo 0.5mL via eFlow, once daily
Other intervention name(s): GIS; GIS; GIS; GIS; GIS; Placebo
Intervention MeSH terms: Glycopyrrolate; Pharmaceutical Solutions
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Chronic Obstructive Pulmonary Disease; COPD; Emphysema; Chronic bronchitis
Kinesio Tape Effects on Ankle Proprioception
Condition: Sprains and Strains
MeSH terms: Sprains and Strains
Study type: Interventional

Summary: 
      The aim of the present study was to establish whether Kinesio Tape (KT) on the ankle (Kase
      protocol for the lateral ankle ligament) improves Joint Position Sense (JPS) in healthy
      volunteers immediately after its application and 48 hours later.
    

Detailed description: 
      The investigators assessed Joint Position Sense (JPS) through the difference of error (DoE)
      and the deviation of the target angle (DTA). JPS was assessed before the Kinesio Tape (KT)
      was placed, immediately after and 48 hours later.
    

Intervention name(s): Kinesio tape
Intervention type(s): Device
Intervention description(s): The KT used was Kinesiology Tape® of 5 cm and it was applied according to Kase protocol (Kase K). The first layer of tape consisted of a single strip placed over the anterior talofibular ligament from insertion to origin, with a 50% tension, except the two-centimetre proximal and distal ends, applied with no tension. The same procedure was repeated for the calcaneofibular ligament and posterior talofibular ligament
Other intervention name(s): Kinesio-tape; Kinesiotape; KinesioTM tape
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: ankle lateral ligament; athletic tape; position sense; Proprioception
Possibilities and Limitations of a New Method for the Measurement of Spine Dynamics During Gait
Condition: Scoliosis
MeSH terms: Scoliosis
Study type: Observational

Summary: 
      The full body marker sets that are typically used in opto-electronic 3D gait analyses either
      disregard the spine entirely or regard it as a rigid structure. Therefore, the purpose of
      this study is to identify the possibilities and limitations of an enhanced trunk marker set
      for the measurement of spine dynamics during gait in adolescents with and without structural
      spine deformities.

      It has been hypothesized that the enhance trunk marker set:

        1. is a valid method for the measurement of spine deformations in the sagittal, frontal and
           indirectly transverse planes.

        2. is an applicable and reliable method for the measurement of spine dynamics during gait
           in healthy adolescents and in patients with structural deformities such as seen in
           scoliosis.

        3. is sensitive enough to distinguish the spinal movement pattern during gait measured in
           scoliosis patients from the one measured in healthy adolescents.

      To verify the hypotheses, the following measurements will be carried out:

        -  Biplanar radiographs (a-p and lateral) with radio-opaque markers in scoliosis patients.

        -  Instrumented gait analysis with a standard full body marker set and the enhanced trunk
           marker set in scoliosis patients and healthy controls.
    


Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Scoliosis patients: Patients attending the Orthopedic Department at UKBB for scoliosis
        treatment.

        Healthy controls: Middle and high school students in the Basel area.
Follicular Steroid Genesis in Controlled Ovarian Stimulation
Condition: Infertility; Controlled Ovarian Hyperstimulation
MeSH terms: Infertility
Study type: Interventional
Phase: Phase 4

Summary: 
      Serum concentrations of the different hormones involved in follicular steroid genesis during
      a cycle of controlled ovarian stimulation with recombinant FSH or HMG will be compared in
      this study. Serum Progesterone (P) levels at the end of Controlled Ovarian Stimulation (i.e.
      the day of triggering) have been related to cycle outcome, in terms of ongoing pregnancy and
      live birth rates. Large cohort studies show that P levels above a certain threshold are
      associated with poorer cycle outcome. The mechanisms behind P elevation are not well
      understood yet. It has been shown that P levels are positively related to ovarian response
      and to the dose of FSH given during COS. Furthermore, it has been well documented that P
      levels at the end of stimulation are significantly higher when recombinant (r) FSH is used
      for COS when compared to HMG, either in a GnRH agonist long protocol or in a GnRH antagonist
      protocol. Some authors suggest that this finding is explained by the fact that COS with rFSH
      provides a higher oocyte yield than when hMG is given, so the higher P levels observed would
      be explained by the larger number of follicles developed when rFSH is used. On the other
      hand, other authors explain this event by a different follicular esteroidogenesis when HMG is
      used for COS compared to rFSH The hypotheisis behind this assumption is that rFSH enhances P
      synthesis from its precursor pregnenolone in the granulosa cells. This P is unable to be
      further metabolized into androgens because of the lack of 17-20 lyase in the human granulosa
      cells, and therefore is delivered into circulation. On the other hand, when HMG is given for
      COS, the ∆4 pathway is promoted, and pregnenolone will be catabolized in to
      Dehidroepiandrostenodione (DHEA), in the theca cells, and this one to Androstenodione, which
      will be finally aromatized in to estrogens. This mechanism will explain the lower P and
      higher E2 levels observed in HMG cycles in comparison to rFSH cycles.
    


Intervention name(s): COS with GnRH antagonists and rFSH; COS with GnRH antagonists and HP-HMG
Intervention type(s): Drug; Drug
Intervention description(s): Controlled ovarian hyperstimulation with GnRH antagonists and rFSH in women with normal ovarian function.; Controlled ovarian hyperstimulation with GnRH antagonists and HP-HMG in women with normal ovarian function.
Other intervention name(s): GnRH antagonists and rFSH; GnRH antagonists and HP-HMG
Intervention MeSH terms: Prolactin Release-Inhibiting Factors
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Induction of Pluripotent Stem Cells From Human Fibroblasts of DM1 Patients
Condition: DM1
Study type: Interventional

Summary: 
      The objective of the study is the modelisation of human cardiomyocyts from pluripotent stem
      cells in order to study the cardiac alterations induced by CTG expansions.
    


Intervention name(s): Clinical examination, skin biopsy, blood and urine sampling
Intervention type(s): Other
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: DM1; Cardiopathy; Adult
Downmodulating Monocyte Activation for HIV-1 Associated Neurocognitive Disorders (HAND)
Condition: HIV Dementia
MeSH terms: AIDS Dementia Complex
Study type: Interventional
Phase: Phase 4

Summary: 
      HIV associated neurological disorders (HAND), are a major problem even in ART treated people.
      HAND results from chronic inflammation which is largely attributed to expansion and
      activation of monocytes. These activated monocytes, some of which also carry virus to the
      brain, invade the CNS and release cytokines / chemokines resulting in further recruitment of
      monocytes, as well as release viral proteins which injure neurons and cause activation of
      other brain cells. Persistent monocyte/macrophage activation is thus a potential critical
      target for adjunctive therapy to treat or prevent HAND. The investigators therefore propose
      to study the effects of a statin drug (Atorvastatin), which has anti-inflammatory functions,
      on the monocyte activation status in ART treated HIV+ individuals.

      The investigators objectives are based on the hypothesis that Atorvastatin treatment will
      reduce the inflammatory and activated phenotype and function of monocytes which have been
      linked to HIV associated neuropathogenesis and occur in HIV infected subjects despite ART. In
      this study the investigators propose to

      1) define the effect of Atorvastatin on monocyte activation in HIV infected / ART treated
      subjects in a double blind, placebo controlled crossover study
    


Intervention name(s): Atorvastatin (generic Lipitor); placebo
Intervention type(s): Drug; Drug
Intervention description(s): Atorvastatin is an FDA approved prescription drug which is frequently used to lower cholesterol levels.It is available in the form of tablets ranging in dose from 10-80mg.; A substance containing no medication and prescribed or given to reinforce a patient's expectation to get well.
Intervention MeSH terms: Atorvastatin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: HIV; monocytes; CD16+; statins; mcp1; inflammation
Effects of Exercise and Relaxation Techniques on Tension Headache Pain Parameters of University Students
Condition: Tension-Type Headache
MeSH terms: Tension-Type Headache; Headache
Study type: Interventional

Summary: 
      Tension headache is a common disabling disease and a worldwide public health problem. This
      research tries to demonstrate the efficacy of physical therapy, based on cervical training
      and postural self-correction instructions, which aims to increase the positive results
      obtained from traditional relaxation techniques (Schultz Autogenic Training). University
      students are selected, because headaches are very common in this sector of the population.
      The design is a non-pharmacological randomized controlled trial, with blinded evaluation of
      the response variables. The investigators compare two independent samples. One of them
      receives an only treatment (Autogenic Training) and the other group receives a combined
      program (Autogenic Training + specific cervical exercises and postural correction). Pain
      parameters (frequency, intensity and duration) and drug consumption are measured before
      treatment, and then, at 4 weeks and 3 months, to value the results.
    


Intervention name(s): Relaxation technique Autogenic Training; Combined treatment Autogenic Training + Cervical exercises and postural correction
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Autogenic Training; Autogenic Training + Cervical exercises and postural correction
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Tension-type headache; relaxation techniques; physiotherapy
Initial Experience With a New Laparoscopic Based Robotically Assisted Surgical System for Cholecystectomy
Condition: Biliary Colic; Cholecystitis
MeSH terms: Cholecystitis
Study type: Interventional

Summary: 
      The Senhance™ surgical robotic system, previously known as Telelap Alf-X (TransEnterix,
      Morrisville, NC, USA) has recently become available in the UK. It aims to provide the robotic
      benefits of greater accuracy, dexterity and control with similar operational costs to
      traditional laparoscopy.

      Patients randomly received either a standard laparoscopic cholecystectomy or the Senhance
      assisted cholecystectomy based on scheduled surgery date. A prospectively maintained database
      of the first 20 patients undergoing cholecystectomy with the Senhance Surgical System was
      retrospectively interrogated and compared to a concurrently treated group of 20
      laparoscopically treated patients during the same timeframe.
    


Intervention name(s): Senhance Assisted Cholecystectomy; Laparoscopic Cholecystectomy
Intervention type(s): Device; Procedure
Intervention description(s): Cholecystectomy performed using Senhance surgical robotic system; Standard laparoscopic cholecystectomy
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Robotic Surgery