bioihbjkbjnl/mcl2 huggingface dataset:
Simplifying the World Health Organization (WHO) Protocol for Hand Hygiene: Three Steps and 15 Seconds
Condition: Hand Hygiene
Study type: Interventional

Summary: 
      This study is to investigate that non-inferiority in terms of reduction of bacterial counts
      will be retained when combining the simpler three-step technique for the use of hand rub with
      a shorter application time of 15 seconds.
    

Detailed description: 
      The WHO guideline recommends 30 seconds for application of hand rub, however, mean bacterial
      reduction after 15 seconds of hand rubbing has been recently shown to be non-inferior and
      shortening application time to 15 seconds has been suggested to improve the frequency of hand
      hygiene actions in a neonatal care unit. This study is to investigate that non-inferiority in
      terms of reduction of bacterial counts will be retained when combining the simpler three-step
      technique for the use of hand rub with a shorter application time of 15 seconds.
    

Intervention name(s): Six-step hand hygiene technique with an application time of 30 seconds; Six-step hand hygiene technique with an application time of 15 seconds; Three-step hand hygiene technique with an application time of 30 seconds; Three-step hand hygiene technique with an application time of 15 seconds
Intervention type(s): Procedure; Procedure; Procedure; Procedure
Intervention description(s): Six-step hand hygiene technique with an application time of 30 seconds; Six-step hand hygiene technique with an application time of 15 seconds; Three-step hand hygiene technique with an application time of 30 seconds; Three-step hand hygiene technique with an application time of 15 seconds
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: two different hand hygiene techniques (six steps and three steps) and two different application times for hand rub (30 seconds and 15 seconds)
Masking: None (Open Label)
Primary purpose: Screening
Keywords: reduction of bacterial counts; hand hygiene technique
Health-Related Quality of Life in Gay Men With Localized Prostate Cancer
Condition: Prostate Cancer
MeSH terms: Prostatic Neoplasms
Study type: Observational

Summary: 
      RATIONALE: Gathering information about prostate cancer, treatment, and quality of life from
      gay men with prostate cancer may help doctors plan the best treatment.

      PURPOSE: This clinical trial is collecting information about health-related quality of life
      from gay men with localized prostate cancer.
    

Detailed description: 
      OBJECTIVES:

        -  To enroll 200 gay men with localized prostate cancer in a cross-sectional study of
           prostate cancer outcomes.

        -  To complete an R01 application using pilot data collected from these patients.

        -  To complete manuscripts describing the factors that influence quality of life and
           treatment satisfaction in these patients.

      OUTLINE: Patients complete a web-based survey about their disease (biopsy Gleason score, PSA
      at diagnosis, and T-stage), treatment (treatment type, time since treatment, and use of
      healthcare services [e.g., oral medications for erectile dysfunction]), symptom distress, and
      psychosocial factors (ethnicity, health literacy, level of social support, communication with
      provider, relationship status, and communication with partner) that affect their
      health-related quality of life. The data will be used to provide the information necessary to
      tailor an existing prostate cancer survivorship intervention to address the specific needs of
      gay men with prostate cancer.
    

Observational model: Ecologic or Community
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Convenience sample contacted via Internet
      
Keywords: stage I prostate cancer; stage II prostate cancer
Distalization by Miniscrew
Condition: Distalization by Miniscrews
Study type: Interventional
Phase: Phase 1

Summary: 
      This study aimed to compare the effectiveness and efficiency of miniscrew-supported and
      standard frog molar distalizing appliances.
    

Detailed description: 
      A prospective randomized clinical trial study was carried out on twenty healthy Egyptian
      subjects, each required molar distalization as part of their comprehensive orthodontic
      treatment. The subjects were selected and treated at the outpatient clinic of the Orthodontic
      Department, Faculty of Dentistry, Ain-Shams University.

      The inclusion criteria in this subject selection in this study was as follows;

        1. All the subjects had an age range from 11 to 16 years with a mean of ±13.5 years.

        2. All the subjects had skeletal Class 1 or mild skeletal Class 2 due to maxillary excess.

        3. All the subjects had bilateral Class II molar relationship.

        4. All subjects were free from any dental anomalies.

        5. All subjects had good oral hygiene. The exclusion criteria in this study was as follows;
           1- Missing permanent teeth with exception of 3rd molar. 2- Previous orthodontic
           treatment. 3- Systemic disease that may influence orthodontic treatment and drug intake.
           4- Periodontal disease. 5- Functional mandibular deviations and facial asymmetry. 6-
           History of parafunctional habits.

      The subjects were equally and randomly divided into two groups; group A and group B which
      included ten subjects per group. These groups were classified according to the type of
      distalizer utilized:

        -  Group A: included ten subjects utilizing the conventional frog molar distalizing
           appliance (CF).

        -  Group B: included ten subjects utilizing the Miniscrews-supported frog molar distalizing
           appliance (MSF)

      The pretreatment and post-distalization Database Records All subjects had the following
      records; a clinical diagnostic sheet, orthodontic study cast (according to ABO index),
      extraoral and intraoral photographs, and CBCT.

      These records were obtained at T1 before distalization and at T2 after distalization.

      The study protocol was approved by the local ethics committee, faculty of dentistry,
      Ain-Shams University. Before commencing with treatment, all the subjects and their guardians
      received a full explanation of the treatment protocol. After which they were asked to sign a
      detailed written consent.
    

Intervention name(s): miniscrew-supported Frog molar distalizing appliance; Standard Frog molar distalizing appliance
Intervention type(s): Device; Device
Intervention description(s): miniscrew 10mm length and 1.7mm diameter FORESTADENT company; Nance buttons attached to first premolars band
Other intervention name(s): Skeletal Frog; Conventional Frog
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Exploratory Study of Efficacy on Selected Natural Extracts Reducing Post Prandial Blood Glucose Response
Condition: Blood Glucose
Study type: Interventional

Summary: 
      Randomized, balanced, incomplete block design exploratory study of efficacy, with 8 active
      treatments (4 treatments per subject; 35 or 37 subjects per treatment) compared to a
      reference treatment (all 72 subjects).
    

Detailed description: 
      Incomplete block design cross over study in which the subjects consumed commercial rice
      porridge (60 grams of extruded rice to which 300 ml of boiling water was added) in the
      morning in a fasted state. On each visit one of the seven different natural exacts was mixed
      into this porridge just before consumption. The reference was consumed by all subjects and
      consisted of plain porridge with no extract added.
    

Intervention name(s): Mulberry fruit; Mulberry leaf; White bean; Apple; Elderberry; Turmeric; Rice porridge
Intervention type(s): Other; Other; Other; Other; Other; Other; Other
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Randomized, balanced, incomplete block design exploratory study of efficacy, with 8 active treatments (4 treatments per subject; 35 or 37 subjects per treatment) compared to a reference treatment (all 72 subjects).
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
Training and Evaluation of Ultrasound-Guided Procedures
Condition: Learning Anesthesia Procedures
Study type: Interventional

Summary: 
      38 certified registered nurse anesthetist (CRNA) students will learn 5 different
      ultrasound-guided regional anesthesia blocks both with and without a novel device, the EDU
      which gives the student help finding the right needle path.
    

Detailed description: 
      38 students enrolled in a course for ultrasound-guided nerve blocks will be participants in a
      study to evaluate the benefit of learning with ultrasound guidance. The EDU, a computer
      assisted guide for ultrasound interventions will be used for half the students for each of 5
      nerve blocks/interventional procedures. Then the students will switch (crossover study) and
      perform the same interventions. Data will be recorded by dint of the tiny video cameras on
      the EDU and anonymized and evaluated.
    

Intervention name(s): With EDU
Intervention type(s): Device
Intervention description(s): using the EDU to perform the procedure
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery
Condition: Ambulation Difficulty
MeSH terms: Mobility Limitation
Study type: Interventional

Summary: 
      Although the aetiology of emergence agitation (EA) derives from multiple factors, it is a
      frequent side effect of sevoflurane anaesthesia in children. Dexmedetomidine, a potent
      selective α2-adrenergic agonist, can reduce the doses of hypnotics, opioids, analgesics, and
      anaesthetics that must be concomitantly administered. This study was conducted to assess the
      effect of dexmedetomidine infusion on sevoflurane requirements and recovery profiles with EA
      in children undergoing ambulatory surgery.
    


Intervention name(s): Dexmedetomidine; normal saline
Intervention type(s): Drug; Drug
Intervention description(s): dexmedetomidine(vs saline) 1 mcg/kg iv bolus during 10minutes, and then, 0.1 mcg/kg/h dexmedetomidine(vs saline) was infused.
Intervention MeSH terms: Dexmedetomidine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Logistic Regression of Risk Factor for the 5-year Mortality of Aortic Dissection
Condition: Aortic Dissection
MeSH terms: Aortic Dissection
Study type: Observational

Summary: 
      The relevant predictive hospital risk factors for 5-year mortality of patients with aortic
      dissection is untill unlear. The aim of this study is to collect the clinical data of 111
      hospitalized patients admitted to hospital from Aug. 2001 to Aug. 2007, and statistically
      analyze the hospital risk factors related to 5-year mortality by univariate and multivariate
      binary logistic regression.
    

Detailed description: 
      Clinical data were collected from 111 hospitalized patients admitted to hospital from Aug.
      2001 to Aug.2007, and the related factors for death within 5 years after the onset of
      dissection, which include Gender, age, history of smoking, hypertension, diabetes, renal
      insufficiency (azotemia), low admission diastolic blood pressure (<70mmHg), Stanford typing
      (Stanford A or B), long-acting calcium channel blocker treatment,ACEI /ARB treatment,
      endovascular stent and surgical aortic replacement,were statistically analyzed by univariate
      and multivariate binary logistic regression.
    

Observational model: Case-Only
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        diagnosed AD patients in Our hospital From August 2001 to August2007
Does Follow-up With Serum Beta Human Chorionic Gonadotropin (BhCG) Simplify Medical Abortion?
Condition: Medical Abortion
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate if BhCG testing to determine the completion of
      medical abortion simplifies the medical abortion protocol. Investigators hypothesize that
      women randomized to ultrasonographic determination of completion of medical abortion will
      have MORE follow-up visits/interventions beyond standard protocol than those randomized to
      medical abortion follow-up with serum BhCG.

      The investigators also hope to explore satisfaction with BhCG based follow-up among women
      seeking medical abortion. Investigators hypothesize that the majority of women who choose to
      follow-up with serum BhCG will be satisfied with this method of medical abortion follow-up.
    


Intervention name(s): serum BhCG follow-up; ultrasonographic follow-up
Intervention type(s): Other; Other
Intervention description(s): Subjects in this arm will receive medical abortion follow-up using BhCG blood draw; Subjects in this arm will receive medical abortion follow-up by ultrasound
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Keywords: medical abortion; serum BhCG follow-up; ultrasonographic follow-up; follow-up methods
Pharmacokinetics of Simvastatin and Its Metabolite Simvastatin Acid With and Without Concomitant Administration of Telmisartan in Healthy Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      To assess the pharmacokinetics of simvastatin and simvastatin acid with/without concomitant
      administration of telmisartan
    


Intervention name(s): Telmisartan; Simvastatin; Telmisartan placebo
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: Telmisartan; Simvastatin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double
Primary purpose: Treatment
Effectiveness of NephroCheckTM Test to Predict Acute Kidney Injury Following Advanced Cardiac Replacement Therapies
Condition: Acute Kidney Injury; Heart Failure
MeSH terms: Acute Kidney Injury; Wounds and Injuries
Study type: Observational

Summary: 
      The purpose of this study is to test how well the NephroCheckTM Test, a noninvasive
      laboratory test performed on urine, predicts loss of kidney function in patients that have
      had a heart transplant or a Left Ventricular Assist Device (LVAD) or Total Artificial Heart
      (TAH) implanted.
    

Detailed description: 
      Current strategies for AKI detection rely primarily on elevations in serum creatinine in
      conjunction with diminished urine output. Unfortunately, deviations in these crude parameters
      of renal function are largely insensitive and late manifestations of AKI, where acute tubular
      necrosis has likely already transpired and therefore well beyond the phase where preventive
      measures may be instituted. Early phase biomarkers, insulin-like growth factor-binding
      protein 7 ("IGFBP7") and tissue inhibitor of metalloproteinases-2 ("TIMP-2") are critical
      mediators of G1 cell cycle arrest of renal tubular cells during the early phase of cellular
      injury, providing a potential therapeutic window to prevent permanent damage. To date, no
      study has evaluated the efficacy of these early phase renal biomarkers for detecting AKI in
      advanced heart failure patients undergoing cardiac replacement therapies.

      Therefore, the aim of this prospective observational study will be to evaluate the
      effectiveness of the NephroCheckTM to predict AKI in patients undergoing transplant, LVAD
      implant, or TAH implant.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients that have had a heart transplant or LVAD implant.
      
Keywords: Left Ventricular Assist Device; Heart Transplantation; Perioperative; Acute Kidney Injury; Renal; Kidney; Total Artificial Heart
Different Strategies for Preventing Severe Acute Malnutrition in Niger
Condition: Malnutrition
MeSH terms: Malnutrition; Severe Acute Malnutrition
Study type: Observational

Summary: 
      Options for large-scale preventive distributions include fortified blended flours,
      ready-to-use foods and direct cash transfer either alone or in combination with family
      protective rations. Finding the most appropriate strategy is essential to prevent child
      malnutrition in countries like Niger with annual hunger gaps. Here, the investigators compare
      different preventive strategies on the incidence of acute malnutrition among children 6 to 23
      months.
    


Observational model: Ecologic or Community
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Children 6 to 24 months
      
Keywords: pediatrics; Ready-to-use Supplementary Food; corn soy blend; cash transfer; prevention of malnutrition; Niger
Interleukin-5 Receptor Expression in COPD
Condition: COPD
Study type: Interventional

Summary: 
      At visit one, after the subject has signed the consent form, subjects will answer questions
      and have maximum reversibility lung function test to determine if they are eligible to
      proceed with the study. Once the study team has proven that the subject is eligible to
      proceed the study team will collect a sputum sample and blood sample to study their cells. At
      visit two the subjects will undergo a research bronchoscopy at this point the study team will
      collect more samples including a BAL sample and another blood sample. Three follow up phone
      calls will be conducted after the procedure to ensure subject safety, the study team will
      record any symptoms that they are experiencing at that time. Throughout this study the
      samples will be analyzed to see if a larger subset of COPD patients could benefit from using
      the drug mepolizumab.
    

Detailed description: 
      During this study the subjects will have a bronchoscopy where the study team will collect
      airway samples to see how the subjects express certain cells. The subjects will also have two
      blood draws to provide information on the number of inflammatory cells that are present in
      their blood. This will help the study team determine if mepolizumab might be able to be used
      in more patients with COPD. The use of mepolizumab in COPD subjects with elevated blood
      eosinophils has been proven effective. However, the cellular mechanisms in the COPD
      population are unknown, including the extent to which these subjects express IL-5 in their
      airway and whether eosinophils are the sole target. Through this study the study team plans
      to provide proof of concept that mepolizumab could target additional IL-5-expressing immune
      cells in the airway, including especially PMNs. The study team will also investigate
      additional feasible biomarkers that could be utilized to predict mepolizumab responsiveness
      in COPD. The study team is hoping to determine if COPD patients with elevated blood
      eosinophils will demonstrate increased concentrations of IL-5 in their bronchoalveolar lavage
      (BAL) fluid and increased expression in their BAL of CD125+ PMNs. To address this hypothesis,
      the following specific aims will be addressed: To define the expression of IL-5R on PMNs in
      COPD and to demonstrate elevated concentrations of IL-5 in BALF obtained from COPD subjects
      with blood eosinophils (≥300/µL).
    

Intervention name(s): Bronchoscopy
Intervention type(s): Procedure
Intervention description(s): Samples obtained during bronchoscopy and blood samples will be evaluated to define inflammatory markers of COPD
Other intervention name(s): Blood Draw
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Using Interventional Informatics to Address Social Determinants of Health During Clinical Care Visits to Promote Behavior Change and PREVENT Cardiovascular Disease
Condition: Cardiovascular Diseases; Obesity
MeSH terms: Cardiovascular Diseases
Study type: Interventional

Summary: 
      Healthcare providers recognize the need for behavior change and the influence of social
      determinants on youth at risk for poor cardiovascular health (CVH), especially among those of
      low-socioeconomic status (SES). Yet, providers lack the time and community data necessary to
      provide tailored, evidence-based care within routine practice. This project will use an
      Interventional Informatics approach to help providers prescribe patient-centered,
      evidence-based physical activity and nutrition prescriptions and link patients to community
      resources to account for social determinants at the point-of-care. This project will
      integrate our existing, novel, Patient-centered Real-timE interVENTion (PREVENT) tool into
      the BJC electronic health record (EHR) and test it with providers and adolescent patients
      at-risk for poor CVH. EHR integration of PREVENT will enable a cyclical, synergistic and
      data-centric approach to impact modifiable risk factors (physical activity and food intake)
      and prevent cardiovascular disease. This approach uses health informatics technology (HIT) to
      deliver data-driven, patient-centered care and generate evidence to support the use of HIT as
      a way to prevent cardiovascular disease across diverse patients and communities.
    


Intervention name(s): PREVENT tool; Wait-list Control
Intervention type(s): Behavioral; Behavioral
Intervention description(s): PREVENT is a novel Health Information Technology tool designed to promote physical activity and healthy food intake among overweight/obese patients at the point of care. PREVENT automates the delivery of personalized, evidence-based behavior change recommendations and provides an interactive map of community resources to help providers link patients to resources in their community.; Will receive routine clinical care. After completion of follow-up measures, control participants will receive a behavior change prescription via the PREVENT tool
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research