Brain During Effort : Effects of Hypoxia With Respiratory Patients
Condition: Chronic Obstructive Pulmonary Disease (COPD); Sleep Apnea Obstructive (OSA); Healthy Volunteers
MeSH terms: Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive; Hypoxia
Study type: Interventional

Summary: 
      Brain oxygenation is determined by the product of CaO2 and the cerebral blood flow (CBF), the
      modification of one or the other can affect the neuronal O2 availability.

      Besides the effect of the PaO2, the CBF is also regulated by the PaCO2. During effort in
      state of hypoxia, the drop of the PaO2 associated to a potential decrease of the PaCO2 and
      therefore of the CBF, can create an important dizziness between the demand and the supply of
      cerebral O2.

      It seems that hypoxia can trouble in a significant way the response of central neurons, just
      as the production of a motor cortex generated motor command.

      Studies suggest that exercise in severe hypoxia condition can constitute a necessary threat
      for brain oxygenation and the motor command, with the consequence a decrease of the exercise
      performance.

      This projects aim to study effects of hypoxia on the brain function for patients suffering
      from chronic respiratory disease. Neurophysiologic responses of the brain while resting or
      exercising, including drip and cerebral oxygenation, cortical excitation and motor command
      resulting for hypoxic subjects before and after a treatment to correct abnormalities of gaz
      in blood.

      The study will use a multidisciplinary and supplementary methodological approach : the
      near-infrared spectroscopy (NIRS) to appreciate the drip and cerebral oxygenation, CBF,
      neurostimulation procedures and electromyography (EMG) to appreciate the cortical
      excitability, measure the level of central activation and motor command.

      The goals of this study will be :

        -  Measure the drip and cerebral oxygenation, the cortical excitability, mechanisms of
           voluntary activation and central fatigue to the effort for the chronic hypoxemic patient
           compared to healthy control subjects.

        -  Analyse disruptions of locomotion parameters and posturographyc, in simple and double
           task, involving different levels of cerebral task.

        -  Analyse acute effects of an improvement of arterial oxygenation for patients suffering
           from chronic obstructive pulmonary disease (COPD) on drip and cerebral oxygenation,
           cortical excitability, mechanisms of voluntary activation and central fatigue.

        -  Evaluate effects of a treatment by continuous positive airway pressure (CPAP) for
           patients suffering from obstructive sleep apnea (OSA) with the same parameters.
    


Intervention name(s): Pedalling exercise on a cycle ergometer; Isolated contractions of the quadriceps
Intervention type(s): Biological; Biological
Intervention description(s): At 80% of the maximal aerobic power, until exhaustion; Until exhaustion
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Hypoxia; Brain; Effort