Dexmedetomidine Combined With Lidocaine Infusion Affect PONV
Condition: Lidocaine; Dexmedetomidine; Nausea and Vomiting, Postoperative
MeSH terms: Nausea; Vomiting; Postoperative Nausea and Vomiting
Study type: Interventional

Summary: 
      BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine
      decreased the incidence of postoperative nausea and vomiting (PONV). The investigators
      investigated whether IV lidocaine plus dexmedetomidine infusion could better reduce the
      incidence of PONV after laparoscopic hysterectomy.

      METHODS: Two hundred and forty women with elective laparoscopic hysterectomy were randomly
      divided into four groups: the control group (group C, n=60) received an equal volume of
      saline, the lidocaine group (group L, n=60) received IV lidocaine (bolus infusion of 1.5
      mg/kg over 10 min, 1.5 mg/kg/h continuous infusion), the dexmedetomidine group (group D,
      n=60) received dexmedetomidine administration (bolus infusion of 0.5 µg/kg over 10 min, 0.4
      µg/kg/h continuous infusion), the lidocaine plus dexmedetomidine group (group LD, n=60)
      received combination of lidocaine (bolus infusion of 1.5 mg/kg over 10 min, 1.5 mg/kg/h
      continuous infusion) and dexmedetomidine administration (bolus infusion of 0.5 µg/kg over 10
      min, 0.4 µg/kg/h continuous infusion). Primary outcome was the incidence of the first 48 h
      nausea, vomiting and PONV after surgery. The secondary outcomes included perioperative
      propofol and remifentanil consumption, postoperative fentanyl requirement, Ramsay sedation
      score, and bradycardia during post-anaesthesia care unit (PACU) stay.
    


Intervention name(s): lidocaine and dexmedetomidine infusion; Saline infusion; Lidocaine infusion; Dexmedetomidine infusion
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Patients received IV bolus infusion of lidocaine (2%) 1.5 mg/kg and dexmedetomidine 0.5 µg/kg diluted with normal saline to 20 ml in the LD group respectively, over 10 minutes before induction of anesthesia, followed by a continuous IV infusion at rate of lidocaine 1.5 mg/kg and dexmedetomidine 0.4 µg/kg made up to 20 mL every hour until 30 min before the end of operation, respectively.; Patients received 20 ml normal saline and 20 ml normal saline in the CON group respectively, over 10 minutes before induction of anesthesia, followed by a continuous IV infusion 20 ml normal saline and 20 ml normal saline every hour until 30 min before the end of surgery; patients received an IV bolus infusion of lidocaine (2%) 1.5 mg/kg made to 20ml with normal saline and 20ml normal saline respectively, over 10 minutes before induction of anesthesia, followed by a continuous IV infusion of lidocaine 1.5 mg/kg made up to 20ml and 20ml normal saline every hour until 30 min before the end of operation, respectively.; Patients received IV bolus infusion of dexmedetomidine 0.5 μg/kg made to 20ml with normal saline and 20ml normal saline respectively, over 10 minutes before induction of anesthesia, followed by a continuous IV infusion of dexmedetomidine 0.4μg/kg made up to 20ml and 20ml normal saline every houruntil 30 min before the end of operation, respectively.
Other intervention name(s): Dexmedetomidine
Intervention MeSH terms: Lidocaine; Dexmedetomidine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
Keywords: Lidocaine; Dexmedetomidine; Postoperative nausea and vomiting; laparoscopic hysterectomy