bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Saline Eustress in Plant Food (ESEPF)
Condition: Healthy Diet
Study type: Interventional

Summary: 
      The aim of the project is to study if supplementation with eustress plant food like lettuce
      grown in mild salinity condition affects health in a healthy population.
    

Detailed description: 
      Salinity can affect the levels of bioactive compounds in leafy vegetables. The aim of the
      project is to verify the impact, if any, of the changing of bioactive compounds in the
      physiology of the study population. The participants will be randomly assigned to the control
      group that will eat 100 gr of untreated (control) lettuce and the intervention group that
      will consume 100gr of eustress lettuce. Blood samples and urine samples will be collected at
      time zero (start) after 12 days. Each subject will be subjected to two venous blood samples
      taken at the beginning of the observation and at the end. The samples obtained will be
      transported in certified containers for the safe transport of biological samples, and,
      subsequently, processed by the experimenters at the laboratories of the Molecular Biology
      section of the University of Palermo. Serum and plasma will be obtained from each blood
      sample. All information thus obtained will be recorded in a database in which each person
      will be identified with a numerical code, in order to comply with current privacy
      regulations. Body weight, Barefoot standing height, Body mass index, Body composition will be
      measured in the different groups of study. Samples will be analyzed and compared for glucose,
      insulin, albumin, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, AST,
      ALT, GGT, ALP, Ferritin, free Iron, transferrin, total proteins, magnesium, calcium, insulin,
      osteocalcin, calcitonin, parathyroid hormone, c terminal peptide of collagen (CTX), Vitamin
      D, Phosphate, Potassium.
    

Intervention name(s): Placebo comparator: Control group. To the control group was assigned lettuce without any change in salinity but with the same characteristic of eustress lettuce (soil, water, harvesting time).; Experimental: Eustress group. To the intervention Eustress group was assigned the eustress lettuce.
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Lettuce without any eustress was assigned to each participant belonging to the control group which ate 100gr every day for 12 day; 100gr of eustress lettuce were assigned to each participant belonging to the intervention group which ate 100 grams every day for a total of 12 days
Other intervention name(s): control lettuce; Eustress Intervention group
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: control vs intervention
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin
Condition: Duodenal Diseases; White Spot Lesion
MeSH terms: Duodenal Diseases
Study type: Interventional

Summary: 
      With our study, we aimed to determine whether there is a correlation between zonulin, which
      plays a crucial role in intestinal barrier function and is implicated in the etiopathogenesis
      of many chronic and autoimmune diseases, and scattered white spots lesions associated with
      lymphatic stasis and inflammation in the duodenum.
    

Detailed description: 
      During esophagogastroduodenoscopy (EGD), rarely encountered lesions in the duodenum present
      as scattered white spots (SWS) on the normal mucosa. Although not fully understood in terms
      of specific association with any particular disease and clinical significance, some studies
      have often observed chronic non-specific duodenitis (CND) and intestinal lymphangiectasia
      (IL) in lesions with SWS. This condition is thought to be related to lymphatic stasis.

      Patients included 63 individuals with identified SWS during EGD and 30 patients with a normal
      appearance of the duodenal mucosa were selected as the control group. SWS lesions were
      categorized into two groups, grade 1 and grade 2, based on the degree of density and
      endoscopic appearance. Biopsies were taken from the duodenum, antrum, and corpus. It was
      examined for IL, CND, giardiasis, and villous atrophy. Venous blood samples were collected
      from all patients for serum zonulin levels.
    

Intervention name(s): sws grade 1; sws grade 2; control
Intervention type(s): Diagnostic Test; Diagnostic Test; Diagnostic Test
Intervention description(s): Blood for zonulin level was drawn from the group of patients with typical white lesions in the duodenum, called grade 1.; Blood for zonulin level was drawn from the group of patients with typical white lesions in the duodenum, called grade 2; Group of patients without scattered white lesions in the dueodenum on endoscopy.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Traditional Chinese Medicine in Individualized Treatment of Patients With Diabetes Symptoms
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      Based on the Individualized treatment of diabetes symptoms to evaluate the method of syndrome
      differentiation treatment of Traditional Chinese medicine.
    


Intervention name(s): Chinese herbal medicine; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): According to the traditional Chinese medicine syndrome of subject to make up a prescription within the 35 kinds of chosen Chinese herbal medicine, and the dosage without limitation.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Chinese herbal medicine; diabetes symptoms
Speckle Tracking Echocardiography Analysis of Left Ventricular Myocardium After Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Obstructive Cardiomyopathy
Condition: Hypertrophic Obstructive Cardiomyopathy
MeSH terms: Cardiomyopathies; Cardiomyopathy, Hypertrophic; Hypertrophy
Study type: Interventional

Summary: 
      Objective to investigate the left ventricular (LV) systolic function by speckle tracking
      echocardiography before and after percutaneous intramyocardial septal radiofrequency ablation
      for hypertrophic obstructive cardiomyopathy (HOCM).

      Percutaneous intramyocardial septal radiofrequency ablation (named Liwen Procedure) is a safe
      and effective treatment approach for HOCM and results in sustained improvement in exercise
      capacity and persistent in reducing left ventricle outflow tract (LVOT) gradient. However,
      the systolic function of the myocardial after Liwen procedure in HOCM patients is not well
      exploration and research. Strain evaluation using speckle tracking echocardiography is an
      excellent tool for assessing regional and global LV functions.

      In this study, the investigators aimed to characterize regional and global strain using
      speckle tracking echocardiography to assess LV radial, circumferential and longitudinal
      systolic myocardial function in patients with HOCM before and after Liwen procedure.
    


Intervention name(s): Percutaneous Intramyocardial Septal Radiofrequency Ablation for hypertrophic obstructive cardiomyopathy
Intervention type(s): Procedure
Intervention description(s): Under transthoracic echocardiography (TTE) guidance, the puncture site is positioned at the apex. A guiding line is applied along the septal long axis and the radiofrequency ablation electrode needle(17G, Cool-tip™ RF Ablation System and Switching Controller;Medtronic, Minneapolis, MN, USA) pierced towards the hypertrophic anterior interventricular septum (AIVS) 8-10 mm from the subaortic valve. Each ablation lasts for up to 12 min and the ablation power is gradually increased from 30-40W. Then, the ablation needle is withdrawn 10 mm to prepare for the next application. Overall, 3-4 applications are performed in each patient. The ablation creates an area of thermal coagulative myocardial necrosis that appears as a hyperechogenic reflection detected by TTE. If deemed necessary, we repeat the procedure at the posterior interventricular septum (PIVS).
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Cardiomyopathy, hypertrophic; Speckle tracking echocardiography
Effects of Different Types of Anaesthesia on Intraocular Pressure During Lumbar Disc Herniation Surgery
Condition: Anesthesia; Disk Herniated Lumbar; Intraocular Pressure
MeSH terms: Intervertebral Disc Displacement
Study type: Interventional

Summary: 
      The aim of this study was to investigate the effects of anaesthesia methods on intraocular
      pressure during lumbar disc surgery performed in the prone position.
    

Detailed description: 
      The study included 75 patients with lumbar disc herniation between the ages of 18-75, with
      the American Society of Anesthesiologists (ASA) 1-2. The patients were randomly divided into
      3 groups: propofol, desflurane, spinal. Intraocular pressure (IOP) was measured at 5 time
      points throughout surgery, including baseline (T1), 10 minutes after anesthesia (T2), 10
      minutes after prone positioning (T3: early prone), 30 minutes after prone positioning (T4:
      late prone), and 10 minutes after returning to the supine position (T5). Hemodynamic
      parameters were measured at these time points. Hemoglobin and hematocrit values were measured
      preoperatively and on the first postoperative day.
    

Intervention name(s): Spinal Anesthesia Group; Desflurane Group; Propofol Group
Intervention type(s): Other; Other; Other
Intervention description(s): Effect of spinal anesthesia on intraocular pressure; Effect of general anesthesia with desflurane on intraocular pressure; Effect of general anesthesia with propofol on intraocular pressure
Intervention MeSH terms: Propofol; Desflurane
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The study included 75 patients with lumbar disc herniation between the ages of 18-75, with the American Society of Anesthesiologists (ASA) 1-2. The patients were randomly divided into 3 groups: propofol, desflurane, spinal. Intraocular pressure was measured at 5 time points throughout surgery, including baseline (T1), 10 minutes after anesthesia (T2), 10 minutes after prone positioning (T3: early prone), 30 minutes after prone positioning (T4: late prone), and 10 minutes after returning to the supine position (T5). Hemodynamic parameters were measured at these time points. Hemoglobin and hematocrit values were measured preoperatively and on the first postoperative day.
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: prone position; intraocular pressure; hemodynamics; anesthesia,spinal; anesthesia,general
Effect of Isoflavone Supplementation Associated With Physical Exercise in the Health Parameters of Postmenopausal Women
Condition: Bloodpressure
Study type: Interventional

Summary: 
      This study evaluate if 10 weeks of mixed exercise combined with isoflavones could have
      greater effects on climacteric symptoms, body composition and hydratation, lipidic and
      inflamatory profile than exercise alone in postmenopausal women. the participants will be
      randomly assigned to the group: placebo and exercise or 100mg of isoflavone and exercise.
    

Detailed description: 
      Several endocrine metabolic changes occur during the climacteric period, due to the lack of
      estrogen and also by the aging process and some studies show that ingestion of isoflavones by
      postmenopausal women may have benefits. Theoretically the isoflavone potentiate the effects
      obtained during exercise
    

Intervention name(s): exercise; isoflavone; Placebo
Intervention type(s): Other; Other; Other
Intervention description(s): The training program consisted of aerobic and resisted combined physical exercises performed during 10 weeks, three times weekly with 45 minutes sessions: 5 minutes of warm-up on treadmill, 20 minutes of aerobic exercises and 20 minutes of resistance exercises.; Daily supplementation in 1 capsule per day of 100mg of isoflavones (containing 3.3% genistein, 93.5% dadzein and 3.2% glycitein).; Daily supplementation in 1 capsule per day containing starch of corn.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: isoflavone; blood pressure; climateric symptoms; exercise
QLB Versus PVB for Acute Pain and Quality of Recovery After Laparoscopic Partial Nephrectomy
Condition: Nerve Block, Nephrectomy, Analgesia
MeSH terms: Acute Pain
Study type: Interventional

Summary: 
      This trial is a prospective, randomized, single-center, open-label, parallel-arm,
      blinded-analysis trial, the objective of which is to evaluate the effect of transmuscular
      quadratus lumborum block (TMQLB) in the pain relief and quality of recovery in laparoscopic
      partial nephrectomy compared with thoracic paravertebral block (TPVB).
    


Intervention name(s): preoperative single-shot TMQLB; preoperative single-shot TPVB; patient controlled intravenous analgesia(PCIA)
Intervention type(s): Procedure; Procedure; Drug
Intervention description(s): The patient is placed in the lateral position. The curved probe of Ultrasound Scanner is used for scan and located vertical to the iliac crest at the posterior axillary line to find the Shamrock sign. The 22-G needle is then inserted in plane and directed to the QL muscle. After the proper position of the needle tip between the psoas major muscle and the quadratus lumborum muscle is confirmed, 0. 6 ml/kg 0.5% ropivacaine is injected into the interfascial plane.
Followed by IPCA in the first 48h after surgery: morphine boluses: 1.5-2 mg, lockout time :10 min, 1h limitation: 6-8 mg morphine.; The patient is placed in the lateral position, the spinous processes of T10 are identified and marks are made 2cm lateral to the spinous processes. The curve probe of ultrasound scanner is placed transversally at the mark to identify the paravertebral space. Then a 22-G needle is inserted in-plane from lateral to medial and advanced until the tip reached the paravertebral space surrounded by the parietal pleura and the superior costotransverse ligament. 0.4 ml/kg 0.5% ropivacaine is injected into the paravertebral space of T10.; at the end of surgery, patient is administered a PCIA with morphine boluses: 1.5-2 mg, lockout time :10 min, 1h limitation: 6-8 mg morphine.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Supportive Care
Reducing Radioisotope Dose: the Half-Dose CZT Study
Condition: Coronary Artery Disease
MeSH terms: Coronary Artery Disease; Myocardial Ischemia; Coronary Disease
Study type: Interventional

Summary: 
      This is a pilot study to see whether cardiac imaging can be performed using half the standard
      dose of radioisotope.
    

Detailed description: 
      The aim of this study is to compare the image quality of the half radioisotope dose scans
      obtained using a CZT (cadmium zinc telluride) camera with scans acquired using a standard of
      care imaging protocol/radioisotope dose performed on a traditional (conventional) camera.

      The proposed strategy of a half dose/extended time protocol with the CZT camera should yield
      a similar count activity and consequently image quality equivalent to that detected by a
      conventional SPECT system.
    

Intervention name(s): Half-dose isotope for NuclearStressTest
Intervention type(s): Other
Intervention description(s): Half-dose of tracer or radioisotope will be used for Nuclear stress test of the heart. This is imaging test of the heart to see the function of arteries of the heart.
Other intervention name(s): SPECT using CZT
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Coronary Artery Disease
Doxapram as an Additive to Propofol Sedation in Sedation for ERCP
Condition: Sedation; Hypoxia
MeSH terms: Hypoxia
Study type: Interventional
Phase: Phase 4

Summary: 
      Sedation is needed in order to complete endoscopic retrograde cholangiopancreatography (ERCP)
      to alleviate discomfort and pain during the procedure. This is usually achieved with use of
      opioids and/or sedative agents such as benzodiazepines or propofol. Traditionally
      benzodiazepines have been used but nowadays propofol is becoming the drug of choice for
      sedation during ERCP.

      The problem with propofol sedation is the fact that it may case cardiorespiratory depression
      and there is no antidote for this like there is for benzodiazepines. Cardiovascular
      depression can usually be easily counteracted with drugs that are used to raise blood
      pressure or heart rate during general anesthesia but respiratory depression remains a
      problem.

      The aim of this study is to try to counteract the respiratory depression caused by propofol
      sedation using an old respiratory stimulant doxapram as opposed to placebo using a double
      blind randomized protocol.

      The investigators hypothesis is that boluses and an infusion of doxapram will alleviate the
      respiratory depression caused by propofol sedation.
    


Intervention name(s): Doxapram; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): An injection and infusion of normal saline (NaCl 0.9%) as a placebo comparator to doxapram
Other intervention name(s): Dopram; Stimulex; Respiram
Intervention MeSH terms: Doxapram
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Supportive Care
Keywords: Cholangiopancreatography, Endoscopic Retrograde; Sedation
Injection of Autologous CD34-Positive Cells for Critical Limb Ischemia
Condition: Peripheral Artery Disease; Peripheral Vascular Disease; Critical Limb Ischemia
MeSH terms: Vascular Diseases; Peripheral Arterial Disease; Chronic Limb-Threatening Ischemia; Peripheral Vascular Diseases; Ischemia
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The purpose of this study is to evaluate the safety and efficacy of intramuscular injections
      of adult stem cells in patients with Critical Limb Ischemia (CLI).
    


Intervention name(s): CD34-positive cells; CD34-positive cells; Saline and 5% autologous plasma
Intervention type(s): Biological; Biological; Biological
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: PAD; PVD; CLI; Stem Cells
Therapeutic Effect of Two Fluoride Varnishes on White Spot Lesions: a Clinical Study
Condition: Dental Caries
MeSH terms: Dental Caries
Study type: Interventional
Phase: Phase 4

Summary: 
      The study hypothesis is the difference in therapeutic effect of two varnish formulations (G1
      = NaF, 2.26%F, G2 = NaF, 2.71% F + CaF2). These products are commercially available in the
      Brazilian and international market and they are used for dental caries as white spot lesions
      control.
    

Detailed description: 
      The aim of this study was to evaluate the therapeutic effect of two varnish formulations (G1
      = NaF, 2.26%F, G2 = NaF, 2.71% F + CaF2) on the remineralization of white spot lesions (WSL).
      The sample was composed of 15 (7- to 12-year-old) children with 45 active WSL in anterior
      permanent teeth. The children were randomly divided in two groups providing 22 lesions for G1
      and 23 for G2. The children were submitted to weekly varnish applications 4 times. The WSL
      were evaluated twice: baseline and on week 4. Maximum lesion dimensions (mesial-distal and
      incisal-gingival) were measured in millimeters and classified in four grades of size. WSL
      were also recorded assessing lesion activity by one calibrated examiner. The Pearson
      chi-square and Fisher's exact tests were used (P < 0.01). WSL reductions were observed in
      both varnish groups (Chi-square= 0.15, d.f.=1, P=0.90); and with similar magnitude (in mm):
      1.19 and 1.29 for G1 and G2, respectively. Thirty-six WLS (15 in G1 and 26 in G2) were
      classified as inactive in week 4 reaching an overall value of 80%. No difference was observed
      between G1 and G2 regarding activity scores (Fisher's exact test, p > 0.01). It can be
      concluded that after 4 applications the two varnish formulations tested produced similar
      clinical effects indicating the reduction and the control of carious activity in most WSL.
    

Intervention name(s): sodium fluoride; sodium fluoride calcium fluoride
Intervention type(s): Drug; Drug
Intervention description(s): sodium fluoride 5%; sodium fluoride 5% + calcium fluoride
Other intervention name(s): Duraphat®, Colgate Palmolive GmbH, Hamburg, Germany; Duofluorid XII®, FGM, Joinville, Brazil
Intervention MeSH terms: Listerine; Calcium; Fluorides; Sodium Fluoride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: White spot lesion; Tooth remineralization; Fluoride varnishes
Preliminary Study of Peel Force and Discomfort of Removal of Adhesive Barriers in Normal and Peristomal Skin
Condition: Dermatologic Complications
Study type: Observational

Summary: 
      This purpose of this study is to look at three commercially available ostomy barriers on
      peristomal (around the stoma) skin. Repeated barrier application and removal over years
      causes changes to the skin that the investigators wish to investigate. The primary objective
      is to measure peel force on normal skin and peel force on peristomal skin, with the intent of
      determining if differences occur. The study hypotheses is that no differences exist.
    

Detailed description: 
      This is a single center, non-invasive exploratory study utilizing a sample of convenience.
      This study compares three commercially available barrier materials on peristomal skin and
      normal abdominal skin.
    

Intervention name(s): Control Abdominal Skin; Peristomal Abdominal Skin
Intervention type(s): Device; Device
Intervention description(s): Three barrier materials will be peeled from abdominal skin after a set period at a set rate.; Three barrier materials will be peeled from abdominal skin after a set period at a set rate.
Other intervention name(s): SoftFlex; FlexWear; FlexTend; SoftFlex; FlexWear; FlexTend
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Ostomates with a normal peristomal skin and normal ipsilateral abdominal skin
      
Keywords: ostomy appliance
Single Anastomosis Sleeve Iejenal Bypass in Obese Patient With Hiatus Hernia
Condition: Obesity, Morbid
MeSH terms: Obesity, Morbid; Hernia, Hiatal
Study type: Interventional

Summary: 
      single anastomosis sleeve jejunal bypass with hiatal repair for morbid obesity with reflux
      manifestations
    

Detailed description: 
      preoperative endoscopy was done and if hiatus hernia was present the patient is undergo
      single anastomosis sleeve jejunal bypass with hiatal repair for morbid obesity with reflux
      manifestations
    

Intervention name(s): Single anastomosis sleeve jejunal bypass with hiatal repair
Intervention type(s): Other
Intervention description(s): Single anastomosis sleeve jejunal bypass with hiatal repair
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment