bioihbjkbjnl/mcl2 huggingface dataset:
Theory Based Integrated Program on Medication Adherence Among Community Dwelling Schizophrenia
Condition: Schizophrenia; Medication Adherence; Medication Compliance
MeSH terms: Schizophrenia
Study type: Interventional

Summary: 
      This clinical trial aims to evaluate the effectiveness of the theory-based integrated program
      in promoting medication adherence in patients with schizophrenia. The purpose of this study
      are:

        -  To explore the effectiveness of the theory-based integrated program in promoting
           community-based schizophrenia patients' adherence to medication(like :motivation,
           attitude and behavior)

        -  To explore the effectiveness of the theory-based integrated program in improving the
           psychiatric symptoms of patients with schizophrenia in the community.

      Participants (the experimental group) received routine home visits from psychiatric mental
      nurses, including drug administration, drug side effects and symptom management, life care,
      and the theory-based program provided by the researcher(treatment as usual + the theory-based
      integrated program).

      The comparison group: received routine home visits from psychiatric mental nurses, including
      drug administration, drug side effects, and symptom management, life care,(treatment as
      usual).
    

Detailed description: 
      Members of the experimental group received routine home visits, plus a 1-hour the
      theory-based program intervention 12 times in the 1st, 3rd, 5th, 7th, 9th, 11th, 13th, 15th,
      17th, 19th, 21st, and 23rd weeks, and each patient received a total of 12 hours of
      intervention.

      The control group received routine home visits by psychiatric mental nurses, and the nurse
      provided patients with answers to questions about medications or care and handling of life
      events. The visits and intervention time frequency were the same as those in the experimental
      group.

      Both groups were received baseline (T0), after the 6th hours intervention (T1) and 12th hours
      intervention by nurses to collect data on the main outcome variables: adherence to
      medication, mental symptoms, motivation to take medication, and attitude towards medication.
    

Intervention name(s): The theory based integrated program
Intervention type(s): Behavioral
Intervention description(s): The theory-based integrated program is administered by a nurse trained in motivational interviewing.In the 12-hour intervention, this program uses motivational interviewing skills to increase the patient's attitude towards medication, enhance the support of significant others around them, and increase the patient's control over their own behavior.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Schizophrenia, Medication Adherence, Randomized control trail,community, schizophrenia
Prescription-grade Crystalline Glucosamine Sulfate Therapy in Erosive Hand Osteoarthritis
Condition: Erosive Osteoarthritis of the Hand
MeSH terms: Osteoarthritis
Study type: Observational

Summary: 
      The objective of this study is to evaluate the efficacy of prescription-grade Crystalline
      Glucosamine Sulfate (pCGS), as an add-on treatment to conventional therapy, compared to usual
      therapy alone, in patients with erosive osteoarthritis of the hand (EHOA).

      This is a 6-months retrospective study including patients with concomitant gonarthrosis and
      EHOA, defined as the presence of central erosion in at least two interphalangeal joints.
      Eligibility criteria are symptoms duration for at least 3 months, with a global hand pain
      score ≥40 mm on a 0-100 Visual Analogue Scale (VAS) and a Functional Index for Hand
      Osteoarthritis (FIHOA) score ≥6. The participants are stratified into two groups based on
      whether or not pCGS, at the daily dose of 1500 mg, was added to the conventional therapy for
      hand osteoarthritis (HOA). The latter consists of education and training in ergonomic
      principles, exercise and the use on-demand of acetaminophen or oral non-steroidal
      anti-inflammatory drugs. Patients are evaluated at baseline, after 3 and 6 months. Primary
      outcome measures are the change from baseline to month 6 in VAS and in FIHOA score. Secondary
      outcomes are duration of morning stiffness, health assessment questionnaire (HAQ), medical
      outcomes study 36-item short form (SF-36), symptomatic drugs consumption and percentage of
      treatment responders, according to the OMERACT/OARSI criteria.
    


Intervention name(s): Glucosamine Sulfate
Intervention type(s): Drug
Intervention description(s): Treatment for at least 6 months with prescription-grade crystalline Glucosamine Sulfate in addition to conventional treatment
Other intervention name(s): Acetaminophen; Non-steroidal anti-inflammatory drugs
Intervention MeSH terms: Acetaminophen; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        The participants are stratified into two groups (pCGS Group and Control Group) based on
        whether or not prescription-grade crystalline GS treatment, prescribed for the actually
        approved indication of knee OA, was added to the conventional therapy. This stratification
        is based on regrouping patients with similar clinical characteristics at baseline.
Efficacy and Safety of Lambdalina (Lidocaine Cream) Versus Placebo as an Anesthetic for Laser Hair Removal
Condition: Local Anesthesia
Study type: Interventional
Phase: Phase 2

Summary: 
      Double-blind, randomized, placebo-controlled trial to assess the efficacy of Lambdalina
      (lidocaine cream) in reducing pain associated with laser hair removal in women.
    


Intervention name(s): Lambdalina® (Lidocaine 4% cream); Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Lambdaline dose: 2 g for 10 cm2.; Placebo dose: 2 g for 10 cm2.
Intervention MeSH terms: Lidocaine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Pain management; Lidocaine
Pharmacokinetic Study of Intravenous Iron Sucrose in Adolescents on Hemodialysis or Peritoneal Dialysis Receiving Epoetin
Condition: Anemia
MeSH terms: Anemia
Study type: Interventional
Phase: Phase 4

Summary: 
      This is an open-label, multicenter pharmacokinetic study of HD od PD patients receiving
      erythropoietin. Patients were administered 100mg of iron sucrose undiluted by slow IV push
      over 5 minutes. Patients underwent serial blood draws and were subsequently followed for 7
      days for safety endpoints.
    

Detailed description: 
      This is an open-label, multicenter pharmacokinetic study of HD of adolescent PD patients
      receiving erythropoietin. Patients between the ages of 12 and 18 were administered 100mg of
      iron sucrose, undiluted by slow IV push over 5 minutes, and underwent serial blood draws. The
      patients were subsequently followed for 7 days for safety endpoints.
    

Intervention name(s): iron sucrose injection USP
Intervention type(s): Drug
Intervention MeSH terms: Ferric Oxide, Saccharated
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Anemia; Pharmacokinetics
Choose to Lose for Women-Weight Loss to Reduce Breast Cancer Risk Factors
Condition: Obesity; Overweight
MeSH terms: Overweight; Weight Loss
Study type: Interventional
Phase: Early Phase 1

Summary: 
      This study is investigating the changes in specific hormone levels in women age 30-45 after a
      12 week weight loss intervention.
    

Detailed description: 
      In sum, excess body weight and inactivity have emerged as strong avoidable causes of
      postmenopausal breast cancer, with the greatest potential for primary prevention occurring
      during the premenopausal years. However, surprisingly, no study to date has examined the
      effects of a standard behavioral weight loss intervention on breast cancer risk markers in
      premenopausal women. Understanding the effects of weight loss in premenopausal women is a
      critical next step in existing research and will inform the development of future breast
      cancer primary prevention programs. The purpose of this study is to determine the feasibility
      of recruiting, treating, and retaining 20 overweight/obese women in a 12-week randomized
      control trial examining feasibility and effects of a behavioral weight loss program on breast
      cancer risk markers in premenopausal women. Participants will be randomly assigned to either
      a 12-week comprehensive behavioral weight loss program (n=10) or control condition (n=10).
      All women will be assessed at baseline and after 3 months of treatment.
    

Intervention name(s): Behavioral Weight loss
Intervention type(s): Behavioral
Intervention description(s): Intervention groups will meet weekly for 12 weeks. Weekly meetings will focus on weight loss in women age 30-45 through behavioral weight loss topics. These topics are designed with the Look AHEAD protocols.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
An Open-Label Study of an Ophthalmic Solution to Reduce Intraocular Pressure in Patients With Ocular Hypertension
Condition: Ocular Hypertension
MeSH terms: Ocular Hypertension; Glaucoma; Hypertension
Study type: Interventional

Summary: 
      The purpose of this study is to determine the safety and tolerability of topical C-KAD
      Ophthalmic Solution in reducing intraocular pressure in patients with ocular hypertension.
    


Intervention name(s): C-KAD Ophthalmic Solution
Intervention type(s): Drug
Intervention description(s): 4 drops applied daily for 150 days
Intervention MeSH terms: Ophthalmic Solutions
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Changes of Inflammatory Cytokines in the Tears of Moderate and Severe MGD Treated With Topical Loteprednol Etabonate
Condition: Moderate and Severe Meibomiang Gland Dysfunction (Stage 3 or Stage 4 Meibomiang Gland Dysfunction)
Study type: Interventional

Summary: 
      Meibum lipids are modified in patients with MGD, resulting in tear instability, evaporative
      dry eye, and eyelid inflammation. These changes add to corneal damages and exacerbate ocular
      symptoms, which are all associated with the constant release of inflammatory mediators. To
      our knowledge, there has been no study on tear cytokine levels in MGD patients treated with
      topical loteprednol etabonate. The investigators, thus, evaluated both inflammatory tear
      cytokine levels and corresponding clinical outcomes for analyzing the efficacy of topical
      loteprednol etabonate in moderate and severe MGD. The aim of this research was to determine
      the concentration of inflammatory tear cytokines in patients with MGD and to compare the
      changes in tear cytokine levels between topical loteprednol etabonate and warm compress
      treatment group and warm compress only treatment group.
    


Intervention name(s): topical loteprednol etabonate (lotemax 0.5%) with warm compress & ocular massage; warm compress only group
Intervention type(s): Drug; Other
Intervention MeSH terms: Loteprednol Etabonate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
In Vivo Damage Induced bu UV in the Epidermis of the Scalp
Condition: Squamous Cell Carcinomas
MeSH terms: Carcinoma, Squamous Cell
Study type: Interventional

Summary: 
      Squamous cell carcinomas (SCC) are the second most common skin cancer in humans. The
      incidence of SCCs in the USA in 2012 was estimated at 700,000 casesSCCs have a metastatic
      course in 3% to 5% of cases that is of poor prognosis. In men, the SCCs of the scalp
      represent the most frequent location of the head and neck, the 3rd location of the whole
      body. The SCCs of the scalp are more undifferentiated than in other locations. In addition,
      actinic keratoses of scalp, precursors of SCC, are more resistant to treatment than in other
      areas. These particularities of the SCCs of the scalp suggest the existence of specific
      factors at the epidermis level of the scalp.

      UV-induced damage to DNA is the defining event in skin photocarcinogenesis. It has already
      been shown that DNA damage induced by UV and the kinetics of repair of this damage may vary
      with age or phototype of patients, but the topographic variation of DNA damage has never been
      studied, although it is known that gene expression in skin cells may differ from one region
      of the body to another.

      the hypothesis is therefore that the particular characteristics of KAs and SCCs at the scal
      level could be explained by an increased sensitivity to UV-induced damage. It is planned to
      study UV-induced damage and its repair at the scalp level in humans compared to the forearm.
    


Intervention name(s): solar irradiation and biopsies
Intervention type(s): Other
Intervention description(s): the minimum erythematous dose (DEM) will be calculated using a solar irradiator on the scalp (study area) and on a forearm (control area). On D2 (D1+24h) a solar irradiation corresponding to 2 DEM will be performed on a region of the scalp (studied area), as well as on a forearm (control area). A 3mm biopsy will be performed 15mn after irradiation in these 2 regions to study DNA damage. At D4 (D2+48h) a 2nd biopsy of 3 mm will be performed to study the repair of induced DNA damage.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Deep Friction Massage: Symptomatic
Condition: Tendinopathy
MeSH terms: Tendinopathy
Study type: Interventional

Summary: 
      Despite DFM being a widely-used technique and the empirical grounding regarding the
      importance of the pressure applied, there is no study characterizing the pressure applied
      during DFM, remaining it a discretion of the physiotherapist. Additionally, it is not known
      how the amount of pressure applied may influence pain mechanisms or function in the
      symptomatic patellar tendon. Having this, our objective is to characterize the pressure
      applied during deep friction massage and evaluate the immediate effects of different
      pressures applied during deep friction massage in the time until analgesia as well as in
      function, in patellar tendinopathy.
    


Intervention name(s): DFM: Mean pressure; DFM: Mean pressure - 25%; DFM: Mean pressure + 25%
Intervention type(s): Other; Other; Other
Intervention description(s): Deep friction massage as described by Dr. James Cyriax, performed with the mean pressure previously obtained in a baseline assessment.; Deep friction massage as described by Dr. James Cyriax, performed with the mean pressure previously obtained in a baseline assessment decremented by 25%.; Deep friction massage as described by Dr. James Cyriax, performed with the mean pressure previously obtained in a baseline assessment incremented by 25%.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: patellar tendon
A First-in-Human Study Evaluating AGA2118 in Men and Postmenopausal Women
Condition: Osteoporosis
MeSH terms: Osteoporosis
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objectives of the study are to assess the safety and tolerability of AGA2118
      after single subcutaneous or intravenous administration in healthy men and postmenopausal
      women and to assess the safety and tolerability of AGA2118 after multiple subcutaneous
      administrations in men and postmenopausal women.
    

Detailed description: 
      This is a Phase I, Randomized, Double-Blind, Placebo-Controlled, Single and Multiple
      Ascending Dose Study to Evaluate the Safety, Tolerability, Absolute Bioavailability,
      Pharmacokinetics, and Pharmacodynamics of AGA2118 in Men and Postmenopausal Women.

      The study consists of the single ascending dose (SAD) part and the multiple ascending dose
      (MAD) part. In the SAD part, up to 56 healthy men and postmenopausal women will be
      sequentially enrolled to receive a single subcutaneous (SC) dose of AGA2118 or a single
      intravenous (IV) dose of AGA2118 or placebo. In the MAD part, up to 32 healthy men and
      postmenopausal women will be sequentially enrolled in various dose cohorts to receive
      multiple SC doses every 4 weeks of AGA2118 or placebo.
    

Intervention name(s): AGA2118; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Part 1 - SAD study: SAD participants in various cohorts will receive various single dose of AGA2118 via either SC or IV.
Part 2 - MAD study: MAD participants in various cohorts will receive various multiple doses of AGA2118 Q4W via SC.; Part 1 - SAD study: SAD participants in various cohorts will receive a single dose of placebo via either SC or IV.
Part 2 - MAD study: MAD participants in various cohorts will receive multiple doses of placebo via SC.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Sugammadex on Remifentanil Ce for Preventing Emergence Cough in Male
Condition: Gallbladder Diseases
MeSH terms: Gallbladder Diseases
Study type: Interventional

Summary: 
      The primary purpose of this study is to investigate the optimal Ce of remifentanil for
      preventing emergence cough following extubation during general anesthesia in male patients
      who are reversed with sugammadex or neostigmine.
    

Detailed description: 
      Remifentanil is a potent ultrashort-acting opioid, with rapid onset and offset of drug
      effect. It allows rapid anesthetic emergence even after a prolonged infusion, and decreases
      the at-risk time during extubation. In addition, cough suppression of remifentanil enables
      smooth extubation with reduced complications. However, the infusion of remifentanil
      suppresses the emergence cough effectively in clinical practice, whereas it still delays the
      awakening from anesthesia, resulting in prolonged emergence time. Reduced Ce of remifentanil
      during emergence would decrease the adverse events that are associated with remifentanil
      infusion.
    

Intervention name(s): Sugammadex Injectable Product; Neostigmine Injectable Product
Intervention type(s): Drug; Drug
Intervention description(s): Sugammadex of 3 mg/kg is injected.; Neostigmine of 50 ug/kg and Glycopyrrolate of 10 ug/kg are injected.
Intervention MeSH terms: Neostigmine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Prevention
Study to Assess the Way the Body Absorbs, Distributes, Breaks Down and Eliminates Radioactive BMS-986278 in Healthy Male Participants
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to assess the way the body absorbs, distributes, breaks down and
      eliminates radioactive BMS-986278 as well as the safety and tolerability of BMS-986278 in
      healthy male participants.
    


Intervention name(s): [14C] BMS-986278; Kinevac®
Intervention type(s): Drug; Drug
Intervention description(s): Specified dose on specified days; Specified dose on specified days
Other intervention name(s): Sincalide
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Healthy volunteers
Healthy Diet for Healthy Moms and Babies
Condition: Gestational Diabetes; Obesity; Pregnancy, High Risk
MeSH terms: Diabetes, Gestational
Study type: Interventional

Summary: 
      The purpose of this clinical study is to collect baseline information on dietary habits and
      metabolic risk factors, and to examine the effects of a dietary intervention focusing on
      fiber and antioxidant rich berries on the development of gestational diabetes, maternal
      glucose and lipid control and inflammation in obese pregnant women at risk of developing
      diabetes. With the ongoing epidemic of obesity, the prevalence of gestational diabetes is
      significantly increasing and the goal of this research is to identify optimal dietary
      strategies that can reverse this condition or control the rise in blood glucose among those
      with already developed diabetes.
    


Intervention name(s): Blueberry + soluble fiber
Intervention type(s): Dietary Supplement
Intervention description(s): Dietary frozen blueberries and soluble fiber for 20 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Care Provider)
Primary purpose: Treatment
Data Construction Project for Artificial Intelligence Learning: Chest Auscultation Sound Data
Condition: Auscultation for Clinical Evaluation
Study type: Observational

Summary: 
      The purpose is to establish chest auscultation data and related clinical data for diagnosing
      heart and lung diseases.
    

Detailed description: 
      The incidence of cardiovascular diseases worldwide is steadily increasing. According to the
      report of the American Heart Association, there were 271 million cardiovascular diseases in
      1990, and 523 million cases in 2019, about doubling in 30 years. The number of deaths due to
      cardiovascular disease is also steadily increasing from 12.1 million in 1990 to 18.6 million
      in 2019.

      Physical examination, which is the most basic skill in patient care, consists of inspection,
      auscultation, percussion, and palpation. Among them, auscultation is the most widely used
      test in all areas where a stethoscope is used, and it is a basic examination that is
      essential from primary medical institutions to tertiary medical institutions for non-invasive
      initial diagnosis in patients complaining of chest symptoms.

      However, if a specialist in the field with a lot of experience does not interpret it
      carefully, it is difficult to make a decision, and the deviation of the test results is
      large, so a significant number of patients depend on expensive follow-up tests (ultrasound,
      CT, MRI, etc.) This leads to a vicious cycle of incurring costs and unnecessary treatment.

      Recently, with the development of machine learning techniques, computing technologies, and
      artificial intelligence (AI) based on a lot of data, various learning technologies are
      applied as tools for disease diagnosis and prognosis prediction in medicine.

      Through machine learning-based chest auscultation sound analysis, there is an expectation
      that disease diagnosis and prognosis prediction will be able to overcome differences and
      interpretations by examiners. It can be very helpful in preventing overuse of tests and
      reducing medical costs.
    

Intervention name(s): Chest auscultation
Intervention type(s): Diagnostic Test
Intervention description(s): Chest auscultation data
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients who obtained chest auscultation will be enrolled.