bioihbjkbjnl/mcl2 huggingface dataset:
Racial Discrimination, Pain, and the Buffering Influences of Acknowledgment
Condition: Pain, Acute
MeSH terms: Acute Pain
Study type: Interventional

Summary: 
      Black young adults (aged 18-30; N = 92) were racially included (i.e., received the ball an
      equal number of times) or excluded (i.e., received the ball only once) by other White players
      in a ball-tossing computer game called Cyberball; White experimenters acknowledged the
      exclusion for half of the excluded participants. Participants completed a cold-pressor task
      twice to measure pain sensitivity (threshold, tolerance, and unpleasantness): immediately
      prior, and after the Cyberball (and acknowledgment) manipulation. Participants also completed
      a post-manipulation survey examining the psychological effects of racial exclusion and
      acknowledgment (i.e., psychological needs satisfaction, negative affect, control).
    


Intervention name(s): Bystander Acknowledgment
Intervention type(s): Other
Intervention description(s): The experimenter said "That is so messed up that they excluded you in the task. And honestly, I would say it was racist…" acknowledgment of the participants experience, "…this shouldn't have happened, and I'm really sorry it did…" an apology, and "…I'm going to talk to the primary investigators of the study to figure out how we can make sure that this won't happen to other people" a plan of action.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Three independent groups
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: discrimination; racism
Study of Efficacy and Tolerability of Various Bowel Preps in Diabetic Patients
Condition: Diabetes Mellitus
Study type: Interventional

Summary: 
      Poor bowel preparation and patient intolerance of the procedure are the most important
      factors contributing to the limitation of colonoscopy. Inadequate bowel cleansing results in
      incomplete testing, increased potential to miss lesions, increased cost, and decreased
      patient satisfaction. The investigators hope to gain better insight into which bowel
      preparation works best in diabetic patients and hence would increase patient satisfaction,
      tolerability of the bowel preparation and decrease overall costs. The investigators will
      investigate which bowel preparation for colonoscopy will work optimally in diabetic patients
      using three different regimens.
    


Intervention name(s): Golytely (polyethylene glycol electrolyte lavage solution) and placebo; split dose of Golytely (polyethylene glycol electrolyte lavage solution) + placebo; split dose of Golytely (polyethylene glycol electrolyte lavage solution) and bisacodyl
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 4 liters of polyethylene glycol electrolyte lavage solution (PEG-ELS-(GoLytely))+ placebo given the evening prior to the colonoscopy; split dose (2 L taken the evening before and 2 L taken the morning of the colonoscopy) of 4 liters Golytely + placebo; split dose ( 2 L taken the evening before and 2 L taken the morning of the colonoscopy) of 4 liters of Golytely + bisacodyl 10 mg
Intervention MeSH terms: Bisacodyl; Pharmaceutical Solutions
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Diagnostic
The Effect of GLP-1 on the Inhibition of Glucagon Secretion
Condition: Type 2 Diabetes; Type 1 Diabetes
MeSH terms: Diabetes Mellitus
Study type: Interventional

Summary: 
      Diabetes(both types) are recognized by high levels of glucagon in the circulation.

      Glucagon is known to increase blood glucose, and might therefore contribute to the respective
      diseases. Under some circumstances the gut hormone GLP-1 inhibits the glucagon secretion.

      The investigators aim to identify the impact of GLP-1 on the glucagon secretion, at
      increasing blood glucose levels in healthy subjects, in patients with type 2 diabetes, and in
      patients with type 1 diabetes.

      The investigators think that the effect of GLP-1 on the glucagon secretion might be dependent
      of blood glucose levels.
    


Intervention name(s): Native human Glucagon-like Peptide-1 ( GLP-1(7-36)); NaCl; Native human Glucagon-like Peptide-1 ( GLP-1(7-36)); Native human Glucagon-like Peptide-1 ( GLP-1(7-36))
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Continuous iv. infusion of the native gut hormone GLP-1 (0.2 pmol/kg/min) for 210 minutes.
Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step); Continuous iv. saline infusion (NaCl Isotonic) for 210 minutes. Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step); Continuous iv. infusion of the native gut hormone GLP-1 (0.4 pmol/kg/min) for 210 minutes.
Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step); Continuous iv. infusion of the native gut hormone GLP-1 (0.8 pmol/kg/min) for 210 minutes.
Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step)
Intervention MeSH terms: Glucagon; Glucagon-Like Peptide 1
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: Glucagon-like peptide-1; Glucagon; Normal physiology; T2DM; T1DM
Comparing Differing Financial Incentive Structures for Increasing Antidepressant Adherence Among Adults
Condition: Depression
MeSH terms: Depression
Study type: Interventional

Summary: 
      The investigators will test using financial incentives by leveraging decision-making biases
      to improve adherence to antidepressants among adults newly prescribed antidepressants. This
      study will compare the effects of usual care, increasing financial incentives, and decreasing
      financial incentives on daily antidepressant medication adherence and depression symptom
      control of non-elderly adults with Major Depressive Disorder.
    

Detailed description: 
      A three arm randomized controlled trial will compare interventions to promote antidepressant
      adherence. One hundred twenty adults with major depressive disorder (MDD) who are initiating
      antidepressant treatment will be randomized in equal proportion to 1) usual care, 2) usual
      care and an escalating daily financial incentive for 6 weeks, or 3) usual care and a
      de-escalating financial incentive for daily antidepressant adherence for 6 weeks. Study
      patients will participate in three assessments over a 12 week period as well as passive
      monitoring of antidepressant daily adherence through a wireless electronic pill bottle over
      the same 12 week period. The primary outcome will be the number of antidepressant daily doses
      taken during the initial six weeks of treatment. The secondary outcome will be daily
      adherence during the next six weeks following the discontinuation of the intervention.
    

Intervention name(s): Financial incentives
Intervention type(s): Other
Intervention description(s): Providing money for taking antidepressant medication
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Health Services Research
Keywords: Medication Adherence
Evaluation of a Primary Type 2 Diabetes Prevention Programme
Condition: Diabetes Mellitus
MeSH terms: Diabetes Mellitus
Study type: Interventional
Phase: Phase 4

Summary: 
      A type 2 diabetes prevention programme, named PREDIAS was developed. It consists of 12
      lessons delivered as group sessions. Die efficacy of PREDIAS was studied in a randomized
      controlled study with 12 month follow up. Control group received written information about
      diabetes risk. Primary outcome variable was weight reduction at 12 months follow up.
      Secondary variables were impact of the intervention on glycemic parameters, lipids, eating
      and exercise behavior and other metabolic risk factors
    

Detailed description: 
      The PREDIAS programme was developed based on the interventions used in the Diabetes
      Prevention Study (DPS, Finland) and the Diabetes Prevention Programme (DPP; USA). The main
      purpose of PREDIAS was to develop a prevention programme delivered as a group programme to
      improve cost-benefit ration of diabetes prevention programmes.
    

Intervention name(s): PREDIAS; Control
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Group programme aiming at modification of lifestyle: lifestyle changes, 12 lesson a 90 minutes, delivered in a group setting, consists of analysis of barriers against lifestyle changes, behavior analysis of eating and exercise behavior, modification of unhealthy lifestyle and relapse prevention; Written Information about diabetes risks. Brochure about the value of a healthy lifestyle, calorie table, suggestions for healthy food and daily exercise
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: diabetes-prevention; lifestyle modification; behavior therapy; self-management
The Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine
Condition: Fever
MeSH terms: Influenza, Human; Fever
Study type: Interventional

Summary: 
      This study aims to conduct a double-blind, placebo-controlled study to assess the effect of
      prophylactic antipyretics on the immune responses and rates of fever after inactivated
      influenza vaccine (IIV) in children 6 through 47 months of age.

      In this study, 160 healthy children, 6 through 47 months of age, including some children at
      risk of febrile seizure, will be randomized to one of three different treatment arms.
      Children will receive either blinded therapy with prophylactic acetaminophen or placebo
      immediately following and every 4 to 6 hours in the 24 hours after receipt of a dose of IIV
      or open-label ibuprofen every 6 to 8 hours in the 24 hours after receipt of a dose of IIV.
      Children will be followed for the occurrence of fever, fussiness, changes in appetite and
      sleep patterns, and use of medical services on the day of and for two days following
      vaccination. Antibody to influenza antigens contained in the respective 2014-2015 and
      2015-2016 vaccines as measured by hemagglutination inhibition (HAI) antibody will be assessed
      at baseline and four weeks following vaccination. The proportions of children experiencing
      fever, having solicited side effects, using medical services, demonstrating a serologic
      response corresponding to seroprotection and seroconversion to each of the IIV antigens will
      be determined for groups of children in each of the three treatment arms. Likewise geometric
      mean HAI titers (GMTs) and corresponding 95% confidence intervals for each IIV antigen will
      be calculated for the three treatment arms. The investigators hope to learn whether or not
      prophylactic antipyretics affect the immune response and fever rates following IIV.
    


Intervention name(s): Acetaminophen Arm; Placebo Arm; Ibuprofen Arm
Intervention type(s): Other; Other; Other
Intervention description(s): Blinded Therapy; Blinded Therapy; Open Label Therapy
Intervention MeSH terms: Acetaminophen; Ibuprofen
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Fever; Antipyretics; Acetaminophen; Ibuprofen; Influenza vaccine; Influenza; Body temperature changes; Signs and symptoms
The Prevalence of White Spot Lesions During Orthodontic Treatment With Fixed Appliances
Condition: Dental Caries
MeSH terms: Dental Caries
Study type: Observational

Summary: 
      This study investigates how often cavities develop on the permanent teeth of patients with
      braces (orthodontic treatment). The hypothesis is that there is no difference in the number
      of cavities on the permanent teeth of patients with braces compared to similar patients
      without braces.
    

Detailed description: 
      The purpose of this cross-sectional study is to determine the prevalence of early carious
      lesions (white spot lesions, or WSLs) for patients who are receiving orthodontic treatment
      compared to patients who are not receiving orthodontic treatment.

      Subjects will be recruited from the University of Kentucky Orthodontic Clinic patient pool.
      Orthodontic care at the University of Kentucky College of Dentistry (UKCOD) is provided by
      orthodontic faculty, as well as students enrolled in the graduate orthodontic program at the
      UKCOD. Subjects will be invited to participate in this study after receiving an initial
      treatment plan with fixed appliances for at least one arch.
    

Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Participants have to be 10 years older who are treatment planned for orthodontic treatment
        with fixed appliances in the Graduate or Faculty Orthodontic Clinic at University of
        Kentucky.

        Based upon the racial distribution of patients currently receiving treatment in the
        Graduate and Faculty Orthodontic Clinics, investigators expect that study population to be
        predominantly Caucasian, with minority representation from the African-American and
        Hispanic communities. The sample composition is expected to be equally weighted with
        respect to gender.
      
Keywords: white spot; lesions; tooth
Effects of Dry Needling and Strain Counter Strain Technique in Myofascial Trigger Points of Upper Trapezius
Condition: Trigger Point Pain, Myofascial
MeSH terms: Myofascial Pain Syndromes; Sprains and Strains
Study type: Interventional

Summary: 
      To determine the effects of Dry Needling and Strain Counter Strain Technique in Myofascial
      Trigger Points of Upper Trapezius
    

Detailed description: 
      It is Randomized Controlled trail will be conduct in Mayo Hospital Lahore and Alnoor Hospital
      Awan town Lahore. Non probability consecutive sampling technique will be used to collect the
      data. Each group contain the 14 patients, Patient will be divided into two groups. Group A
      will be experimental group treated by Dry needling and strain counter strain with baseline
      treatment and Group B will be control group treated by Strain counter strain with baseline
      treatment(Hot pack 10 mints,stretching,Neck isometrics). Neck Disability index (NDI) ,visual
      analogue scale(VAS) and goniometer will be used as data collecting tools.
    

Intervention name(s): Dry Needling; Strain counter strain
Intervention type(s): Other; Other
Intervention description(s): Hot pack 10 mints,stretching,Neck isometrics, dry needling(DN) and Strain counterstrain(SCS); Hot pack 10 mints, stretchings,Neck isometrics, Strain counterstrain(SCS)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Dry needling; Myofascial trigger points; Upper Trapezius; Strain counter strain
Bread Daily Intake Enriched With Mix Fibers in Metabolic Subjects: Intestinal Microbiota and Metabolic Profile Impact
Condition: Healthy Obesity, Metabolically
MeSH terms: Obesity, Metabolically Benign
Study type: Interventional

Summary: 
      The level of fibre consumption in France is lower than the national and international
      recommendations (mean 18.8 g/d for men, 16.4 g/d for women (INCA 2007 Study) instead of 30g/d
      recommended). Fibre have beneficial effects on health and interact with the intestinal
      microbiota diversity: a diet fortified with different structure fibres increase of 25 % the
      dysbiotic intestinal microbiota in obese patient (Cotillard et al, Dietary intervention
      impact on gut microbial gene richness. Nature, August 2013). The study aim is to evaluate the
      impact of daily consumption of bread (150 g ) enriched with a mixture of fibres of different
      structure (15g) during two months on the intestinal microbiota composition in metabolic risk
      subjects (abdominal overweight or obese) and also, to assess the correlation between the
      microbiota change and their metabolic profile improvement.It is a mono centric study with a
      centre in LYON (Centre de Recherche en Nutrition Humaine Rhône-Alpes)
    


Intervention name(s): 150 g bread fortified (15 g mix fibre); 150 g unfortified bread
Intervention type(s): Other; Other
Intervention description(s): Daily consumption of 150g of a bread fortified in fibre mix (15g) during eight weeks.; Daily consumption of 150g of an usual bread in fibre-unfortified bread during eight weeks
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Evaluate PF-00547659 On Cerebrospinal Fluid Lymphocytes In Volunteers With Crohn's Disease Or Ulcerative Colitis Who Failed Or Did Not Tolerate Anti-TNFs
Condition: Crohn's Disease; Ileitis; Ileo-colonic and Colonic Crohn's Disease; Granulomatous Colitis; Regional Enteritis; Ulcerative Colitis
MeSH terms: Crohn Disease; Colitis; Colitis, Ulcerative; Enteritis; Ileitis; Ulcer
Study type: Interventional
Phase: Phase 1

Summary: 
      Study is designed to show a lack of effect on white blood cells circulating in the spinal
      fluid.
    


Intervention name(s): lumbar puncture; lumbar puncture
Intervention type(s): Procedure; Drug
Intervention description(s): 2 lumbar punctures prior to treatment; study drug 225mg SC once a month X 3 doses.; 1 lumbar puncture before and after 3 doses; study drug 225mg SC once a month X 3 doses.
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Crohn's disease lumbar puncture anti-MAdCAM monoclonal antibody PF-00547659 Ulcerative Colitis
Study to Examine the Effects of MultiStem in Ischemic Stroke
Condition: Ischemic Stroke
MeSH terms: Stroke; Ischemic Stroke; Cerebral Infarction; Ischemia
Study type: Interventional
Phase: Phase 2

Summary: 
      A study to examine the safety and potential effectiveness of the adult stem cell
      investigational product, MultiStem, in adults who have suffered an ischemic stroke. The
      hypothesis is that MultiStem will be safe and provide benefit following an ischemic stroke.
    


Intervention name(s): MultiStem; Placebo
Intervention type(s): Biological; Biological
Intervention description(s): single infusion 1-2 days following ischemic stroke; single infusion 1-2 days following ischemic stroke
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: ischemic stroke; adult stem cells
Velcade®-Melphalan Association in Autologous Stem-Cell Transplantation (ASCT)
Condition: Multiple Myeloma
MeSH terms: Multiple Myeloma; Neoplasms, Plasma Cell
Study type: Interventional
Phase: Phase 2

Summary: 
      Intensification with autologous stem cell (ASCT) is currently the most effective treatment
      for subjects under 65 and the essential goal is to achieve complete response (CR) or very
      good partial response (VGPR= greater than 90% reduction of monoclonal component). However,
      only 50% of patients achieve this CR/VGPR even with tandem ASCT early in the course of
      disease.

      Optimization of the conditioning regimen could improve this CR/VGPR rate. The combinaison of
      Velcade and HD Melphalan has never been evaluated. However, at conventional doses, Velcade
      potentiates the antimyeloma effect of Melphalan without inducing any common toxicity.

      This study will be conducted in patients under the age of 65 with de novo multiple myeloma or
      in first relapse, with Salmon and Durie stage of III, II, I with one symptomatic bone lesion
      (radiological)and no contraindication to intensification. The primary objective will be to
      increase the CR/VGPR rate 3 months after autologous peripheral blood stem cell
      transplantation conditioned by Velcade-Melphalan from 40% to 70%. With alpha=5% and bêta=10%,
      61 patients will be included.

      Secondary objectives will be to assess the toxicity of the Velcade-Melphalan conditioning
      regimen, the progression-free survival and the overall survival after intensification.
      Response rates will be evaluated according to the response criteria defined by. Analysis will
      be performed on an intention-to-treat basis.

      After conventional induction therapy and PBSC collection, patients will be offered this new
      conditioning regimen. they will be free to refuse this regimen, in which case they will
      receive standard intensification therapy by Melphalan 200 mg/m² followed by autologous stem
      cell transplantation.

      Evaluation will occur at 3 months post intensification.
    


Intervention name(s): Bortezomib
Intervention type(s): Drug
Intervention description(s): bortezomib-Melphalan
Other intervention name(s): Velcade
Intervention MeSH terms: Bortezomib
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Multiple Myeloma; Autologous Stem Cells Transplantation; High Dose Melphalan; Bortezomib