Meteorin-like Levels in Individuals With Periodontitis
Condition: Periodontitis; Gingivitis; Healthy
MeSH terms: Gingivitis; Periodontitis
Study type: Observational

Summary: 
      Metrnl has proven to be an inflammatory-related immunoregulatory cytokine and shown to play a
      role in the pathogenesis of human inflammatory diseases. Metrnl is highly expressed from the
      oral mucosa to the esophagus. Periodontitis is a chronic inflammatory disease that can start
      with localized inflammatory reactions created by the supporting tissues surrounding the teeth
      against microorganisms and then result in loss of teeth. The authors think that Metrnl may
      play a role in the periodontitis. The aim of this study is to compare the Metrnl, TNF-α,
      IL-1β, TGF-β, IL-10 and VEGF levels of healthy and periodontitis individuals.
    

Detailed description: 
      Periodontitis is a destructive chronic inflammatory disease that can start with localized
      inflammatory reactions created by the supporting tissues surrounding the teeth against
      microorganisms and then result in loss of teeth. Cytokines play an important role in
      inflammation that occurs in periodontal disease.

      Tumor Necrosis Factor-α (TNF-α), Interleukine -1β ( IL-1β )and Interleukine-6 (IL-6),
      Prostaglandin E2 (PGE2) and Interferon gamma (IFN- γ) levels are associated with periodontal
      destruction in the pathogenesis of periodontal disease. Vascular endothelial growth factor
      (VEGF) are important features of inflammation, wound healing and bone healing. Cytokines such
      as Interleukine-10 (IL-10) and transforming growth factor- β (TGF-β) have been reported to
      decrease periodontal disease progression rate.

      Gingival crevicular fluid shows the cellular response in the periodontium. The most important
      host-related ingredients are inflammatory markers, including cytokines, enzymes, and
      interleukins. Saliva analysis is used in the diagnosis of systemic conditions as well as in
      the diagnosis of oral pathologies.

      Meteorin- like (Metrnl) is a protein that plays a role in natural and acquired immune-related
      functions and inflammatory responses, and expressed in barrier tissues (skin and mucosa) as
      well as various macrophage populations, from dendritic cells and some granulocytes. Metrnl
      has proven to be an inflammatory-related immunoregulatory cytokine and shown to play a role
      in the pathogenesis of human inflammatory diseases. Metrnl, which is highly expressed from
      the oral mucosa to the esophagus, may play a role in the onset of periodontitis and an
      effective marker in preventing the progression of destruction. We think that Metrnl plays an
      important role in periodontitis, an inflammatory disease. The aim of this study is to compare
      the Metrnl, TNF-α, IL-1β, TGF-β, IL-10 and VEGF levels of healthy and periodontitis
      individuals
    

Intervention name(s): Saliva; gingival crevicular fluid
Intervention type(s): Other; Other
Intervention description(s): individuals' saliva samples will be collected and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.; GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.
Other intervention name(s): sampling; sampling
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Individuals will be divided into three different groups, about 20-25 people in each group.
      
Biospecimen description: 
      Gingival Crevicular Fluid and Saliva
    
Keywords: Meteorin-like