bioihbjkbjnl/mcl2 huggingface dataset:
Fitness Training After Traumatic Brain Injury
Condition: Craniocerebral Trauma
MeSH terms: Brain Injuries; Craniocerebral Trauma
Study type: Interventional

Summary: 
      The aim of this project is to compare the efficacy of two different fitness exercise
      programmes on improving fitness and psychosocial functioning in a traumatic brain injured
      population. We hypothesize that a supervised fitness-centre based exercise programme,
      compared to an unsupervised home-based exercise programme will show significant improvements
      in cardiorespiratory fitness, depression and community integration.
    

Detailed description: 
      The objective of this project is to compare a three-month supervised fitness centre-based
      exercise programme to a 3-month unsupervised home-based exercise programme on discharge from
      inpatient rehabilitation on improving cardiorespiratory fitness and psychosocial functioning
      in a traumatic brain injured population. We plan to carry out a multi-centre, assessor
      blinded, randomised controlled trial with a parallel group design to compare the two
      interventions. We hypothesise that the supervised fitness-centre based programme will provide
      significantly better outcomes, and that these gains will not only be evident on completion of
      the programme, but will be maintained on follow-up, thereby demonstrating that investment in
      a supervised exercise programme can provide beneficial long-term effects.
    

Intervention name(s): Cardiorespiratory fitness training
Intervention type(s): Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single
Primary purpose: Treatment
Keywords: 'traumatic brain injury'; 'head injury'; 'brain injuries'; 'exercise therapy'; 'physical fitness'
Baby Friendly Initiative Implementation: Maternity Staff Experiences
Condition: Experience, Life
Study type: Observational

Summary: 
      This qualitative, case study will explore the experiences of maternity staff in England when
      implementing the World Health Organisation and Unicef Baby Friendly Initiative (BFI)
      standards within a maternity organisation.
    

Detailed description: 
      A range of maternity staff over 4 UK NHS hospitals will be recruited and interviewed by one
      chief investigator regarding their experiences of working with the BFI standards in their
      daily professional practice.
    

Intervention name(s): Interviews and focus groups
Intervention type(s): Other
Intervention description(s): Unstructured and semi-structured interviews with open ended questions.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Maternity and neonatal staff who meet the inclusion criteria.
      
Keywords: Staff experience,barriers,challenges,facilitators
Therapeutic Potential of Omega-3 Fatty Acids Supplementation in Dry Macular Degeneration and Stargardt Disease
Condition: Dry AMD; Stargardt Disease 1
MeSH terms: Macular Degeneration; Stargardt Disease; Geographic Atrophy
Study type: Interventional

Summary: 
      Prospective, randomised, double-blind study to assess the Therapeutic Potential of Omega-3
      Fatty Acids Supplementation in Dry Macular Degeneration and Stargardt Disease (Macular
      Degeneration Omega-3 Study - MADEOS.
    

Detailed description: 
      Age-related macular degeneration (AMD) is the leading cause of blindness in developed
      countries. By the year 2040, the number of people suffering from AMD is estimated to increase
      by 50%. Stargardt disease is the most prevalent form of macular dystrophy in children, with
      an estimated prevalence of 1 in 10000.

      There is no effective treatment available that stops progression or improves vision in
      patients with dry AMD or Stargardt disease.

      Considering the success in animal studies and observational human studies with omega-3 fatty
      acids supplementation when the blood ratio AA (arachidonic acid)/EPA (eicosapentaenoic acid)
      is <2, the sponsor hypothesizes that, when the blood ratio of AA/EPA is maintained below 2,
      the visual acuity in the group with active supplements will improve, in comparison to the
      control group, in patients with moderate and severe dry AMD and moderate and severe
      Stargardt.
    

Intervention name(s): Madeos; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Arm 1: Omega 3; Arm 2 : Placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Omega-3; dry AMD; Stargardt; visual acuity
Ultrasonography vs Cole Formula to Predict Endotracheal Tube Diameter
Condition: General Anesthesia
Study type: Interventional

Summary: 
      This study aims to compare the accuracy of measurement between ultrasonography and Cole
      formula in predicting uncuffed endotracheal tube diameter.
    

Detailed description: 
      Approval from Ethical Committee of Faculty of Medicine Universitas Indonesia was acquired
      prior conducting the study. Subjects were given informed consent before enrolling the study.
      Non-invasive blood pressure (NIBP) monitor, ECG and pulse-oximeter was set on the subjects in
      the operation room. The uncuffed endotracheal tube (ETT) diameter predictions were measured
      firstly using ultrasonography (USG), then with Cole formula. After that, polyvinyl chloride
      (Mallinckrodt) ETT intubation with Cole diameter measurement was inserted using direct
      laryngoscopy. If the ETT was too small, use a 0.5 mm bigger ETT than the prediction diameter,
      if it too big, use a 0.5 mm smaller ETT than the prediction diameter. Reintubation and
      measurements using both methods were recorded. If bradycardia or desaturation happened,
      positive pressure ventilation, 100% oxygen, atropine 0,01-0,02 mg/kg, adrenaline 0,01 mg/kg
      could be given. Data was analyzed using SPSS using Bivariat Chi-square test or Fisher Exact
      Test (categorical comparative analytical study).
    

Intervention name(s): USG; Cole Formula
Intervention type(s): Device; Other
Intervention description(s): USG used was SonoSite® M-Turbo Bothell, WA, USA, probe linear (Array HFL 38 frekuensi 6-13 MHz). Internal subglottic diameter equals external diameter of the uncuffed endotracheal tube or trachea diameter, result rounded to the smallest uncuffed endotracheal tube size.; Internal diameter of the uncuffed endotracheal tube equals (age in years/4) + 4mm.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Cole formula; Pediatric patients; intubation; Ultrasonography; Endotracheal tube; uncuffed; pediatric
Walking Training With Partial Body Weight Support on Static and Dynamic Surfaces in Stroke Survivers
Condition: Stroke
MeSH terms: Stroke; Body Weight
Study type: Interventional

Summary: 
      The purpose of this study is evaluate the effects of walking training with partial body
      weight support on static (floor) and dynamic (treadmill) surfaces in individuals with
      hemiparesis due to stroke. For this purpose, two training protocols will be employed in three
      experimental groups: G1 will do the walking training with partial body weight support on
      static surfaces and G2 will do the walking training with partial body weight support on
      dynamic surfaces
    


Intervention name(s): Static surface; Dynamic surface
Intervention type(s): Procedure; Procedure
Intervention description(s): During all session time the subject will walk on the floor with partial body weight support. This protocol will be repeated in all sessions.; During all session time the subject will walk on the treadmill with partial body weight support. This protocol will be repeated in all sessions.
Other intervention name(s): floor walking training; Treadmill Training
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Rehabilitation; Gait; Stroke; Biomechanics
Detection of Bone Marrow Changes: Comparison of MRI and DECT
Condition: Bone Marrow Changes
Study type: Observational

Summary: 
      Prospective study where magnetic resonance imaging is compared to dual-energy computed
      tomography for the detection of bone marrow changes.
    


Intervention name(s): magnetic resonance imaging
Intervention type(s): Other
Intervention description(s): magnetic resonance imaging is compared to dual-energy computed tomography for the detection of bone marrow changes
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with bone marrow changes
A Multicenter, Randomized, Open Label Trial of a New Animal Extracted Surfactant to Treat RDS in Preterm Infants
Condition: Respiratory Distress Syndrome
MeSH terms: Respiratory Distress Syndrome; Respiratory Distress Syndrome, Newborn; Syndrome
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      The purpose of this study is to determine the efficacy and safety of the new pulmonary
      surfactant produced by Butantan Institute among premature infants with gestational age below
      34 weeks with RDS, comparing to the pulmonary surfactants commercially available in Brazil.
    

Detailed description: 
      Exogenous surfactant replacement therapy has been one of the major advances in the treatment
      of premature infants with respiratory distress syndrome (RDS). It has decreased the mortality
      among premature infants with RDS, determining changes in the children mortality rates among
      the developed countries. High cost, however, has been a major handicap for its wide use in
      developing and underdeveloped countries. Based on that, Butantan Institute (Sao Paulo,
      Brazil) has developed a new porcine pulmonary surfactant preparation at lower production
      cost. Initial animal studies showed similar improvement in lung mechanics and histopathologic
      findings to those observed with commercially available preparations.

      Comparison(s): The new surfactant developed and produced by Butantan Institute will be
      compared to the commercially available pulmonary surfactants in Brazil, regarding to the
      efficiency to maintain a good arterial oxygenation, low airway pressures after treatment,
      similar mortality rates, and similar rates of complications like bronchopulmonary dysplasia
      and pulmonary hemorrhage.
    

Intervention name(s): Butantan; Control
Intervention type(s): Drug; Drug
Intervention description(s): Use of Butantan surfactant 100 mg/kg, IT, maximum of 3 doses; The pulmonary surfactants commercially available in Brazil Survanta or Curosurf: 100 mg/kg, IT, maximum of 3 doses.
Other intervention name(s): Butantan Surfactant; Survanta or Curosurf
Intervention MeSH terms: Poractant alfa; Beractant
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Respiratory distress syndrome; Pulmonary surfactant; Mortality; Prematurity
hCG Priming in Women With Low Ovarian Reserve
Condition: Infertility, Female; Ovarian Reserve; In Vitro Fertilization
MeSH terms: Infertility; Infertility, Female
Study type: Interventional
Phase: Phase 4

Summary: 
      The aim of this trial is to examine the possible effects of hCG administration for eight
      weeks prior to IVF/ICSI in women with low ovarian reserve. Primary outcome is the proportion
      of the antral follicle count that reach the pre-ovulatory stage.
    

Detailed description: 
      One of the fundamental goals in In Vitro Fertilisation (IVF) is obtaining a high number of
      good quality oocytes, in order to select and transfer embryos with the highest possible
      implantation potential thereby optimizing the chance of a pregnancy and ultimately a live
      birth. This is done by applying an individualized controlled ovarian stimulation (iCOS)
      protocol, primarily based on ovarian reserve markers like antral follicle count (AFC) and
      Anti-Müllerian hormone (AMH), when deciding the follicle stimulating hormone (FSH)
      stimulation dose. Certain patients, the so called "poor ovarian responders' (PORs), pose a
      clinical challenge because they have a poor ovarian reserve and develop a limited number of
      pre-ovulatory follicles in respond to ovarian stimulation despite high FSH stimulation doses,
      thus experiencing reduced live birth rates.

      The aim of the present study is to examine the possible effects of long-term LH activity by
      the administration of hCG for eight weeks in between two identical IVF/ICSI cycles and
      compare cycle characteristics and outcome. The primary outcome is the follicular output rate
      (FORT) which reflects the proportion of antral follicles at the start of controlled ovarian
      stimulation that reaches the pre-ovulatory state. Secondary outcomes include amongst others
      AMH and antral follicle count at baseline (cd 2-3), number of pre-ovulatory follicles,
      oocytes retrieved, and embryos developed.

      We hypothesize that eight weeks of androgen priming by hCG increases the proportion of antral
      follicles that reaches the pre-ovulatory state during controlled ovarian stimulation for
      IVF/ICSI in women with poor ovarian reserve.
    

Intervention name(s): Ovitrelle
Intervention type(s): Drug
Intervention description(s): Ovitrelle 260 IE once daily for 8 weeks prior to IVF/ICSI
Intervention MeSH terms: Chorionic Gonadotropin
Intervention model: Single Group Assignment
Intervention model description: Women will undergo two identical consecutive IVF/ICSI treatments: a Control cycle including blastocyst culture and freeze-all and a subsequent identical Study cycle, separated by eight weeks of androgen priming by daily hCG-injections. Both IVF/ICSI cycles are performed in the fixed GnRH-antagonist protocol using a daily dose of 300 IU rFSH initiated from cd 2-3 and the GnRH antagonist (Fyremadel 0.25 mg) from stimulation day 5-6.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: IVF; Poor ovarian reserve; Controlled ovarian stimulation; Ovarian stimulation; hCG priming
Modulation of Cerebral Blood Flow Using Iron Chelators
Condition: Stroke; Problem of Aging
MeSH terms: Stroke
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The purpose of this study is determine if the iron chelator, desferrioxamine can increase
      blood levels of hypoxia-inducible transcription factor 1 (HIF-1 protein) and to see if there
      is a corresponding increase in blood flow to the brain.
    


Intervention name(s): desferrioxamine
Intervention type(s): Drug
Intervention description(s): intravenous infusion at 10mg/kg/hr for a total of 6 hours at final infused doses of 60mg/kg.
Other intervention name(s): Desferal, desferoxamine
Intervention MeSH terms: Deferoxamine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: brain blood flow; stroke; cerebrovascular; aging; cerebrovascular hemodynamics
Acute Phase Reactant in Non-COVID-19 Bacterial Pneumonia
Condition: Pneumonia; Acute-Phase Reaction
MeSH terms: Pneumonia; Acute-Phase Reaction
Study type: Observational

Summary: 
      This study is a cross-sectional study, was conducted at Chest department of Kasr Al-ainy
      Hospital, Cairo university during the period between October 2020 and April 2021.

      The aim of the work was to evaluate levels of acute phase reactants(APR) in Non-COVID-19
      bacterial pneumonia, and to correlate between levels of APR and the disease severity.
    

Detailed description: 
      51 patients were included in our study, diagnosed as Non-COVID pneumonia

      Inclusion criteria:

        1. PCR(polymerase chain reaction) negative for COVID.

        2. All patients of both sexes with pneumonia .

      Exclusion criteria:

        1. Non pulmonary infections.

        2. Post surgery patients.

        3. Renal patients.

        4. hepatic patients.

        5. Cardiac patients.

        6. Recent pulmonary embolism.

      Methodology in details:

      All patients were subjected to:

        1. Full history with emphasis on:

             -  Epidemiological features (age, gender).

             -  Risk factors (smoking, DM).

             -  Clinical presentation (cough, Fever and duration of illness).

        2. Clinical examination (local chest examination).

        3. Laboratory investigations: venous blood samples were taken to measure APR
    

Intervention name(s): Blood sampling
Intervention type(s): Diagnostic Test
Intervention description(s): blood sampling to measure APR
Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        All patients( 51 patients diagnosed as non-COVID19 Pneumonia) were subjected to:

          1. Full historywith emphasis on:

               -  Epidemiological features .

               -  Risk factors (smoking, DM).

               -  Clinical presentation (cough, Fever and duration of ilness).

          2. Clinical examination (local chest examination).

          3. Laboratory investigations: venous blood samples were taken for:• Complete blood
             picture, differential leucocytic count and platelets count, ESR ,CRP, d-dimer and
             ferritin
      
Biospecimen description: 
      • Complete blood picture, differential leucocytic count and platelets count: Done by The
      newly developed automated hematology analyzer (Sysmex, Kobe, Japan) enumerates and classifies
      blood cells by a combination of direct current detection and flow cytometry. (Daves et al.,
      2015).
Effects of Preparing Parents To Participate In Their Child's Care In The Recovery Room
Condition: Perioperative Nursing
Study type: Interventional

Summary: 
      The objectives of this study were to evaluate the effect of a preoperative educational DVD on
      parents' knowledge acquisition, participation and anxiety related to their child's care in
      the recovery room (RR). It also aimed at evaluating the DVD in terms of children's
      postoperative distress, pain, analgesic requirements and length of recovery.
    

Detailed description: 
      Following the development of a validated preoperative educational Digital Versatile Disc
      (DVD) for parents, a randomized clinical trial, with a pre-test-post-test control group, was
      conducted on 123 French or English speaking parent-child dyads whose child was aged from 3 to
      10 years and underwent an ear-nose-throat (ENT) or dental same day surgery at a Canadian
      pediatric hospital. The parents in the control group received the standard preoperative
      preparation (verbal and written information about hospital procedures and the hospital's
      surgical virtual tour). The parents in the experimental group viewed the DVD and received the
      standard preoperative preparation. Parents and children were videotaped in the recovery room;
      parental participation and children's distress were measured using observational scales. A
      validated multiple choice questionnaire was used to measure parents' knowledge acquisition,
      whereas a visual analogue scale allowed parents to report their anxiety level prior to,
      during and after their stay in the recovery room. A chart review was conducted to collect
      data on children's postoperative pain, analgesic requirements and length of recovery. In
      order to assess the effect of the DVD on parents and their child, T-test, chi-square analyses
      and repeated measures ANOVAs were conducted among 105 dyads.
    

Intervention name(s): "You and your child in the recovery room" DVD; Standard pre-operative preparation
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Attendance to the Pre-anesthetic assessment clinic to meet with registered practical nurse and anesthesiologist (physical assessment and medical history). Completion of the Surgery Virtual Tour.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)
Condition: Dental Plaque; Gingivitis
MeSH terms: Gingivitis; Dental Plaque
Study type: Interventional
Phase: Phase 4

Summary: 
      The objective of this clinical research study is to assess the efficacy of a commercially
      available triclosan/copolymer toothpaste compared to a commercially available oral hygiene
      multi-component regimen encompassing the use of a manual toothbrush, a toothpaste containing
      stannous fluoride / sodium hexametaphosphate and a mouthwash containing cetylpyridinium
      chloride relative to a negative control regimen in reducing established dental plaque and
      gingivitis over three and six months of assigned product use.
    


Intervention name(s): Triclosan/fluoride toothpaste; stannous fluoride toothpaste; fluoride only toothpaste; Cetylpyridinium chloride mouthwash; Fluoride only mouthwash
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): Brush whole mouth with Total toothpaste (triclosan/fluoride) using Total 360 toothbrush for 1 minute, 2 times/day for 6 months (study duration).; Brush whole mouth with Crest Pro-Health toothpaste using an Oral B Pro-Health toothbrush for 1 minute, 2 times/day for 6 months (study duration).; Brush whole mouth with Crest Cavity Protection toothpaste using an Oral B Indicator toothbrush for 1 minute, 2 times/day for 6 months (study duration). Immediately after each brushing, rinse whole mouth with 20 ml of Crest fluoride Mouthwash for 30 seconds.; Immediately after each brushing with Crest Pro-Health toothpaste, rinse whole mouth with 20 ml of Crest Pro-Health Mouthwash for 30 seconds.; Immediately after each brushing with Crest Cavity Protection toothpaste, rinse whole mouth with 20 ml of Crest Pro-Health For Me mouthwash for 30 seconds.
Other intervention name(s): Total toothpaste; Crest Pro-Health toothpaste; Crest Cavity Protection toothpaste; Crest Pro-Health Multi-Protection Mouthwash; Crest Pro-Health For Me Breezy Mint mouthwash
Intervention MeSH terms: Triclosan; Cetylpyridinium; Fluorides; Tin Fluorides
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Study of Baricitinib in Participants From 2 Years to Less Than 18 Years Old With Juvenile Idiopathic Arthritis
Condition: Juvenile Idiopathic Arthritis
MeSH terms: Arthritis; Arthritis, Juvenile
Study type: Interventional
Phase: Phase 3

Summary: 
      The reason for this study is to see if the study drug baricitinib given orally is safe and
      effective in participants with JIA from 2 years to less than 18 years old.
    


Intervention name(s): Baricitinib; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Administered orally.; Administered orally.
Other intervention name(s): LY3009104
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Polyarticular JIA; Oligoarthritis; Juvenile psoriatic arthritis (JPsA); Enthesitis-related juvenile idiopathic arthritis (ERA)