bioihbjkbjnl/mcl2 huggingface dataset:
The Effects of Mental Fatigue Created by Social Media on Upper Extremity Performance
Condition: Mental Fatigue; Upper Extremity Performance; Social Media
MeSH terms: Fatigue; Mental Fatigue
Study type: Observational

Summary: 
      There are a limited number of studies in the literature, and it is stated that mental fatigue
      caused by social media use causes a decrease in upper-extremity movement speed and a decrease
      in lower-extremity endurance performance. Therefore, this study aims to determine the effects
      of social media-induced mental fatigue on upper extremity performance.
    

Detailed description: 
      Mental fatigue is a psychobiological condition that requires prolonged cognitive activity and
      is characterized by subjective feelings of "tiredness" and "lack of energy." It reduces
      sport-related decision-making, technical skills, motor control and endurance performances.
      This has led to a condition known as social media fatigue among many users, where they feel
      exhausted from repeated exposure to an enormous amount of information from brands. Social
      media fatigue is "the tendency of social media users to withdraw from social media when they
      are overwhelmed by too many social media sites, too many friends and followers, and too much
      time spent online to maintain these connections".Researchers have drawn attention to the
      negative effects of internet-induced fatigue, which is increasing daily, and emphasized that
      excessive internet use can lead to physical and psychological problems. Although there are a
      limited number of studies in the literature, there is a limited number of studies
      investigating the effects of mental fatigue caused by social media use on upper extremity
      performance.Therefore, this study aims to determine the effects of mental fatigue caused by
      social media on upper extremity performance.
    

Intervention name(s): Social Media Fatigue
Intervention type(s): Other
Intervention description(s): Mental Fatigue creation protocol: It has been reported that at least 30 minutes of social media use causes mental fatigue and impairs lower extremity and decision-making performance (Fortes et al., 2021). For mental fatigue with social media, participants will be created with 45 minutes of continuous use of social media (instagram, facebook, twitter, youtube) on smartphones by concentrating with headphones.
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        It will be conducted on Bandırma Onyedi Eylül University Faculty of Health Sciences
        students.
A Virtual Reality Intervention to Improve Weight Maintenance
Condition: Weight Loss
MeSH terms: Body Weight; Weight Loss
Study type: Interventional

Summary: 
      The purpose of this study is to determine if use of a virtual reality platform, Second Life,
      is more effective than traditional face-to-face methods for maintaining weight loss in
      overweight and obese individuals.
    

Detailed description: 
      This study has two main parts. During the first 6 months (-6 to 0 months)potential subjects
      will be on a diet developed by researchers at the University of Kansas Medical Center (KUMC).
      Subsequent to 6 months, participants who lost 5% weight will begin the weight maintenance
      phase of the study (0-12 months). Thus the total duration of the study is 18 months.

      Approximately 68% of U.S. adults are classified as overweight or obese (BMI >25).
      Behaviorally based weight loss programs, typically delivered by face-to-face clinics, produce
      clinically significant reductions in body weight over 3-6 months. However, approximately 50%
      of those who lose weight regain more than 45-75% of the weight lost within 12-30 months.
      Face-to-face clinics present many barriers and burdens to individuals including scheduling
      and logistical and financial burdens.

      Virtual Reality (VR) environments allow participants to create virtual representations of
      themselves called "avatars". An existing VR called "Second Life" will be used for
      participants randomized to VR. Participants avatars attend group meetings and use headsets
      for voice communication to interact with each other.

      Those not randomized to VR will participate in traditional face-to-face group weight loss
      intervention. The study will examine many different factors to determine if those
      participants in the Second Life group experience improved weight maintenance.
    

Intervention name(s): Second Life; Group Phone Conference Call
Intervention type(s): Other; Behavioral
Intervention description(s): Second Life is an online virtual reality environment.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Obesity; Overweight; Weight Maintenance
Safety Study to Evaluate the Effects of Mild and Moderate Renal Impairment on the Pharmacokinetics of ABT-335 and Rosuvastatin When Administered Concomitantly
Condition: Dyslipidemia, Renal Insufficiency
MeSH terms: Renal Insufficiency; Dyslipidemias
Study type: Interventional
Phase: Phase 1

Summary: 
      Safety Study to Evaluate the Effects of Mild and Moderate Renal Impairment on the
      Pharmacokinetics of ABT-335 and Rosuvastatin When Administered Concomitantly
    


Intervention name(s): ABT-335; Rosuvastatin
Intervention type(s): Drug; Drug
Intervention description(s): 45 mg once daily for 10 consecutive days; 10 mg once daily for 10 days
Intervention MeSH terms: Rosuvastatin Calcium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Dyslipidemia
Young Adult Smoker's Treatment Demand
Condition: Smoking Cessation
Study type: Observational

Summary: 
      The purpose of this study is to determine whether tailored online advertisements will drive
      young adult smoker's (18 to 26 years old), who are motivated to quit, to use Internet-based
      cessation treatment.
    


Intervention name(s): Online advertisement
Intervention type(s): Behavioral
Intervention description(s): Internet advertisement with messages tailored for young adult smoker's motivated to quit
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Young adult Internet users
Evaluation of Treatments for Homeless Youths
Condition: Substance Abuse
MeSH terms: Substance-Related Disorders
Study type: Interventional
Phase: Phase 2

Summary: 
      Youth who leave home for the streets are at significantly more risk for a multitude of
      problems, yet little research is available to guide treatment intervention efforts with this
      population. Studies document high rates of substance use, HIV risk, mental health problems,
      teenage pregnancy and criminality. Research to date examining homeless, street living youth
      has been primarily descriptive; less effort has been directed towards developing and
      evaluating treatment interventions for this group. The majority of homeless youth do not
      receive substance abuse treatment, with one study reporting that only 15% of street living
      youth report ever receiving mental health services. The effectiveness of the Community
      Reinforcement Approach (CRA) with street living youth was studied in our recently completed
      Stage 1 trial. The proposed study is a Stage II clinical trial examining outcome of CRA
      individual therapy as compared to two interventions commonly employed, yet little researched,
      with this group. All clients will be randomized to one of three theoretically distinct
      interventions: (1) CRA therapy, (2) Motivational Enhancement Therapy (MET), or (3) Case
      Management (CM). The relative effectiveness of these interventions will be evaluated at 3, 6,
      and 12 months post-baseline. The Social Ecology Theory of Development (Bronfenbrenner, 1979)
      guides our change hypotheses and intervention. Proposed change mechanisms (mediators) for
      each intervention will be evaluated. Differential treatment response as a function of
      ethnicity, gender, age, sexual orientation and abuse (moderators) will be investigated to
      better understand the interventions. The study will also examine how, if at all, treatment
      engagement, retention and expectations impact youth response to the three treatments.
      Information gained through this project may help address the gap in our understanding of how
      best to effectively intervene with a group at high risk for continuing health and
      psychological problems.
    


Intervention name(s): Community Reinforcement Approach (CRA) + HIV prevention; Case Management + HIV Prevention; Motivational Enhancement Therapy (MET) + HIV prevention
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): 12 sessions of the CRA and 2 sessions of HIV prevention.; 12 sessions of case management and 2 sessions of HIV prevention.; 2 sessions of MET and 2 sessions of HIV prevention.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Substance abuse; Homelessness; HIV risk behavior
Neopep-S Ingredient Easy Dew MD Regen Cream
Condition: Dry Skin
Study type: Interventional

Summary: 
      The purpose of this clinical study is to provide patients diagnosed with dry skin due to
      various causes such as atopic dermatitis and Yangjin The effect on skin regeneration after
      applying EasyDew MD Regen Cream containing Neopep-S, a regeneration factor, and It is
      intended to assess safety.
    

Detailed description: 
      The total study period for this clinical study is 12 months from the date of IRB approval,
      led by researchers from a single institution It's a clinical study. The individual
      participation period of the participant is one month.

      Subjects are those diagnosed with dry skin due to a variety of factors (and/or courts)
      Agents) perform screening tests after agreeing in writing to participate in the clinical
      study.

      Evaluating the screening test results, and subjects who meet the selection criteria and do
      not meet the exclusion criteria, for clinical research It must be registered. Random
      assignments of the study group and control group are conducted in a random number table at a
      5:5 ratio.

        -  Control group: 10 people with dexian med cream

        -  Research Group: 10 people applying EasyDew MD Regen Cream Clinical study subjects are
           randomly assigned to control and study groups. The control group is Dexian, a foreign
           medical device product Med cream is applied, and in the case of the study group,
           EasyDewMD Regen cream provided through prescription is applied. clinical practice
           Subjects apply an appropriate amount twice a day (morning and evening) to skin areas
           with dry skin symptoms and can be absorbed well Let's make it happen. After applying the
           medical device for clinical research, the progress is observed for one month, and the
           subject is subject to about one month of clinical research During the period, research
           institutes will be regularly visited to evaluate their validity and safety on the day of
           screening (Visit1), the day of medical device application (Visit2), 2 weeks after
           medical device application (Visit3), and 1 month after application (Visit4).
    

Intervention name(s): Easy Dew MD Regen Cream
Intervention type(s): Device
Intervention description(s): The subject applies the provided medical device twice a day (morning and evening) to areas with symptoms of dry skin so that it can be absorbed well.
Other intervention name(s): Physiogel Stability Intensive Cream MD
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
RYGB and the Gastric Adipose Axis
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine if interruption in gastric-adipose tissue axis
      signaling contributes to early improvements in oxidative stress, insulin sensitivity, and
      inflammation, and to determine if interruption of the stomach in RYGB results in reduction of
      plasma acylated ghrelin (AG) and in an altered acylated ghrelin:unacylated ghrelin (AG:UAG)
      ratio which may contribute to decreased oxidative stress and improved insulin sensitivity.
    


Intervention name(s): human ghrelin; very low calorie diet; Hyperinsulinemic/Euglycemic Clamp
Intervention type(s): Drug; Other; Procedure
Intervention description(s): 0.5-1 pmol/kg.min of human ghrelin administered by IV two times; standard very low calorie diet that is prescribed for all RYGB patients after their operation; Insulin and glucose infusions to measure glucose kinetics.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Obesity; Bariatric surgery; Nashville, Tennessee
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of CC-99677 in Healthy Adult Subjects
Condition: Healthy Volunteer
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a phase 1, randomized, single-center, 3-part, FIH study to assess the safety,
      tolerability, pharmacokinetics (PK, or how the drug behaves in the body), and
      pharmacodynamics (PD, or what the drug does to the body) of single and multiple doses of
      CC-99677 and to characterize the effect of food on the single-dose PK of CC-99677 in healthy
      adult subjects.
    

Detailed description: 
      This first-in-human (FIH) study aims to identify a safe and tolerable dose of CC 99677 in
      support of phase 2 and/or phase 3 studies to be conducted in subjects with underlying
      inflammatory diseases.

      The study also aims to evaluate the PK of CC-99677 following administration of single and
      multiple oral doses, including assessment of the effect of food on the single dose PK of CC
      99677, and to assess the effect of CC 99677 on electrocardiogram (ECG) parameters in healthy
      adult subjects. The pharmacodynamics (PD) and pharmacogenomics (PG) of CC 99677 will also be
      assessed.

      Parts 1 and 2 are designed to evaluate the safety, tolerability, PK, and PD of single and
      multiple ascending doses of CC 99677, respectively. The study has been designed to allow for
      safety, tolerability, and PK data to be gathered in a stepwise fashion. Part 1 will consist
      of escalating single doses in sequential groups. Approximately 48 subjects will be enrolled
      into 6 planned dose level cohorts. Part 2 will consist of escalating multiple doses
      (administered for 14 days) in sequential groups. In Part 2, approximately 40 subjects will be
      enrolled into 5 proposed dose level cohorts. Each dose level cohort will consist of 8
      subjects; 6 subjects will receive CC-99677 and 2 subjects will receive placebo according to
      the randomization schedule. In both Part 1 and Part 2, a higher daily dose level will not be
      initiated until adequate information on the preceding dose level is available and reviewed.
      Parts 1 and 2 will also employ strict dose escalation, individual subject, and intra cohort
      stopping criteria. Parts 1 and 2 will be placebo controlled to appropriately characterize the
      safety and tolerability of CC 99677.

      Part 3 is designed to characterize the effect of food on the single dose PK of CC 99677.
    

Intervention name(s): CC-99677; Placebo
Intervention type(s): Drug; Other
Intervention description(s): CC-99677; Placebo
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Healthy Volunteer; Safety; CC-99677
Cognitive-behavioral Therapy for Generalized Anxiety Disorder in Primary Care
Condition: Generalized Anxiety Disorder
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      The feasibilty and preliminary comparative effectiveness of two methods of
      cognitive-behavioral therapy - metacognitive therapy and intolerance of uncertainty therapy -
      for primary care patients with generalized anxiety disorder is investigated in a pilot study
      using a randomized controlled design. Purpose of the study is to examine the feasibility of a
      full-scale randomized controlled trial. Research questions primarily concern recruitment,
      measurement, and adherence.
    


Intervention name(s): Metacognitive therapy; Intolerance of uncertainty therapy
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Metacognitive therapy is a form av cognitive-behavioral therapy which aims to change cognitions about worry in patients with generalized anxiety disorder.; Intolerance of uncertainty therapy is a form av cognitive-behavioral therapy which aims to reduce cognitive and behavioral avoidance of uncertain situations or cognitions which lead to worry in patients with generalized anxiety disorder.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
iCBT for Children and Adolescents With Obsessive-compulsive Disorder II
Condition: Psychotherapy Intervention Evaluation
MeSH terms: Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Study type: Interventional

Summary: 
      Internet-based psychotherapy for children and adolescents with obsessive-compulsive symptoms
      and an age of 6 to 18 years. Sessions are verified with teleconferencing with an
      psychotherapist, children and their parents. The psychotherapy is supported by an App and a
      wristband to obtain psychophysiological data. The investigators have already successfully
      performed a feasibility study.The goal of the current proposal is to develop an internet and
      smart phone delivered CBT (iCBT) for the treatment of pediatric OCD on the bases of the
      feasibility study. Internal testing on iCBT therapy package and developmental workchanges has
      been done. The investigators are now evaluating effectiveness in an RCT.
    

Detailed description: 
      In this study the investigators test effectiveness of an internet-based therapy approach for
      children with obsessive-compulsive disorders in an RCT design with a waiting control group.
      The investigators are planninng the investigation of 20 patients in each group.Therapy is
      verified by experts via teleconferences and a therapy app. Outcomes for the treatment group
      are evaluated before randomization (baseline, t0), 16 weeks (end of treatment, t1), 32 weeks
      (follow-up 1, t2), and 48 weeks after randomization (follow-up 2, t3). For the waiting
      list-group, outcomes are measured before the first randomization (baseline), at 16 weeks
      (waiting list period), 32 weeks (end of treatment), 48 weeks after the first randomization
      (follow-up I) and 64 weeks after the first randomization (follow-up II).
    

Intervention name(s): Cognitive-behavioral psychotherapy
Intervention type(s): Behavioral
Intervention description(s): The goal is to develop an internet and smart phone delivered CBT (iCBT) for the treatment of pediatric OCD on the bases of our feasibility study. This group will start directly with therapy of 16 weeks. The waiting group gets the same intervention after 16 weeks of waiting.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: cognitive-behavioral psychotherapy; obsessive-compulsive disorder; internet-based
Post Operative Pain Assessment After Pulpectomy of Primary Molars With Two Different Rotary Systems
Condition: Pulp Necroses
MeSH terms: Dental Pulp Necrosis; Pain, Postoperative; Necrosis
Study type: Interventional

Summary: 
      Evaluation of post operative pain after pulpectomy procedures for primary molars with
      irreversible pulp damage and without periapical radulicency using two different systems (One
      shape file ( ratation movemont) and wave one gold file ( reciprocation movement)
    


Intervention name(s): Pulpectomy using single file system ( One Shape file); Pulpectomy using single file system ( WaveOne Gold file)
Intervention type(s): Other; Other
Intervention description(s): Rotary file instrument for pulpectomy of primary molars ( One shape file); Rotary file instrument for pulpectomy of primary molars ( WaveOne Gold file)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Other
The Improvement in Uroflow and Postvoid Residual Urine After Urethral Meatotomy in Children With Meatal Stenosis
Condition: Urethral Meatal Stenosis
MeSH terms: Constriction, Pathologic
Study type: Observational

Summary: 
      The improvement in uroflow and postvoid residual urine in children after urethral meatotomy
      for meatal stenosis. The hypothesis is that there is an improvement in both parameters, thus
      justifying the procedure.
    

Detailed description: 
      Urethral meatal stenosis is a known complication of circumcision occuring in up to 3% of
      newborns undergoing circumcision. It is customary to perform a meatotomy in order to prevent
      bladder outlet obstruction, although bladder outlet obstruction has never been proven and
      improvement has only been proved in a single, small, retrospective study. Our intention is to
      evaluate the improvement in objective parameters (uroflow and postvoid residual urine) after
      urethral meatotomy by measuring these parameter before the procedure, one month after the
      procedure and one year after the procedure. Symptoms assessment will also be performed.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Toilet trained children, before puberty, scheduled for urethral meatotomy for the treatment
        of urethral meatal stenosis.
      
Keywords: Meatal stenosis; Meatotomy; Uroflow; Postvoid residual
Beneficial Effects of Microsurgical Varicocelectomy on Semen Parameters for Causes Other Than Infertility
Condition: Varicocele
MeSH terms: Infertility; Varicocele
Study type: Observational

Summary: 
      The purpose of this study is to evaluate whether clinical varicoceles are associated with
      abnormal semen parameters and whether varicocelectomy could improve the semen parameter in
      patients unrelated with infertility.
    

Detailed description: 
      While most studies are continued to validate the observations of significant improvements in
      sperm density and motility after varicocele ligation in infertile patients, there have been
      few studies to investigate the effects of varicocelectomy on semen parameters in adult men
      unrelated with infertility. The purpose of this study was to determine whether
      varicocelectomy could improve the semen parameter of these patients as well as whether
      clinical varicoceles are associated with abnormal semen parameters in patients unrelated with
      infertility.
    

Intervention name(s): Microsurgical subinguinal varicocelectomy
Intervention type(s): Procedure
Observational model: Case-Only
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        men with clinical varicoceles underwent microsurgical varicocelectomy due to causes other
        than infertility such as testicular pain, discomfort or scrotal mass