bioihbjkbjnl/mcl2 huggingface dataset:
Assessment of Validity of Depth by PocketCPR as Sites of Smartphone on Arm
Condition: Chest Compression With Smartphone
Study type: Observational

Summary: 
      For Cardiopulmonary Resuscitation(CPR) education, depth of chest compression is most
      important teaching point. However, the tool to feedback depth of chest compression like
      Resusci Annie Skill Reporter(Laedal Medical AS, Norway) is very helpful but too expensive to
      be used widely. In these days, smartphone free application can measure depth of chest
      compression in real-time. This study assess the validity of depth of chest compression by
      smartphone application, PocketCPR, as three sites of smartphone on arm or hand.

      1. grap it in hand, 2. fix it on upper arm with arm band, 3. grap it in hand with arm band

      To analyze the difference between Skill Reporter manikin and PocketCPR application, the
      investigators will use Intraclass Correlation Coefficient(ICC) as statistical method.
    


Intervention name(s): Site of smartphone on chest compressor' arm
Intervention type(s): Device
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Basic Life Support certtification licenced by American Heart Association

        Clinical experience more than 3 years associated with CPR
COPD Treatment by Transplantation of Autologous Bronchial Basal Cells
Condition: Chronic Obstructive Pulmonary Disease (COPD)
MeSH terms: Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Chronic obstructive pulmonary disease (COPD) is a group of disease characterized by
      obstructed airflow. Usually, the lung structure is gradually impaired along with the
      progression of the disease. Recently, the treatment of disease is challenged by shortage of
      approaches for regenerating the injured lung tissue. Here in this study, investigators intend
      to perform a single-centered, open, concurrent-controlled phase I/II clinical trial with
      autologous bronchial basal cells on COPD treatment since they were proved to regenerate lung
      tissue in animal models. The participants is recruited and divided into experiment group and
      control group. For patients from experiment group, bronchial basal cells will be isolated,
      expanded, carefully characterized in vitro and transplanted autologously into lung by
      fiberoptic bronchoscopy. No intervention is performed for patients from control group. During
      the study, the safety and efficacy will be evaluated on all the subjects by measuring the key
      indicators.
    


Intervention name(s): Autologuos transplantation of bronchial basal cells
Intervention type(s): Biological
Intervention description(s): Autologuos transplantation of bronchial basal cells
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: COPD; cell therapy; bronchial basal cells; autologous transplantation
Role of Ipsilateral Motor Cortex in Executing Movements With Increasing Demand on Precision
Condition: Stroke
MeSH terms: Stroke
Study type: Observational

Summary: 
      It is well known that the motor area of one hemisphere of the brain (motor cortex) controls
      the movement of the opposite of the body. However, it is not clear whether as the movement
      becomes more complicated, the motor cortex of both hemispheres of the brain are involved.
      Currently the role of the motor cortex on the same side of the body (referred to as
      ipsilateral motor cortex) in hand performance remains controversial. The investigators
      demonstrated previously in healthy subjects that transiently lowering the activity of
      ipsilateral motor cortex improved the performance of the opposite hand. What is not know are
      the mechanisms involved in these changes of behavior. Transcranial magnetic stimulation (TMS)
      is a device that allows the non- invasive stimulation of the brain. When brain is stimulated
      repetitively at a very low rate and low intensity for about 15 minutes, the stimulated brain
      area becomes less active. This effect lasts 10 minutes and is called a "transient artificial
      lesion" as it mimicks the effects of transiently interfering with the function of the
      stimulated brain area. In the present study the investigators will conduct experiments using
      repetitive TMS to downregulate the activity of the motor area as in previous experiments and
      measures its effect on activity of motor cortex of both hemispheres. The investigators will
      study healthy subjects. It would be important to understand the effects in more detail for
      the design of treatment strategies in patients after stroke, which will be a topic of future
      studies.
    


Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        30 Stroke patients with 15 in each group based on location of stroke 50 healthy volunteers
      
Keywords: Stroke; Physical Medicine & Rehabilitation; Neurology; Neurophysiology; Neuroscience; Transcranial Magnetic Stimulation (TMS)
The Comparison of Warming Techniques in Patients Undergoing Open Abdominal Surgery in Litotomy Position
Condition: Temperature Change, Body
MeSH terms: Body Temperature Changes
Study type: Interventional

Summary: 
      The patients scheduled to undergo major abdominal surgery in litotomy position will be
      randomized into two groups in order to compare the effects of two warming techniques during
      the intraoperative period.
    

Detailed description: 
      The patients will be randomized into two groups. All patients will receive prewarming with
      forced-air warming device for 30 minutes. All patients will receive warmed fluids during
      intraoperative period. One group will receive warming with only forced-air warming device and
      the other group will receive warming with both forced-air warming device and water mattress.
      Timpanic, esophageal and peripheral temperature monitoring will be performed.
    

Intervention name(s): HICO-VARIOTHERM 550; Mistral-Air Plus forced air warming device
Intervention type(s): Device; Device
Intervention description(s): Warming during perioperative period.; Warming during perioperative period.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Apomorphine Nasal Powder in the Treatment of Parkinson's Disease "Off" Periods.
Condition: Parkinson's Disease
MeSH terms: Parkinson Disease
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      To determine the safety and tolerability of repeated dosing with Apomorphine Nasal Powder in
      subjects with Parkinson's Disease.
    


Intervention name(s): Apomorphine Nasal Powder
Intervention type(s): Drug
Intervention MeSH terms: Apomorphine
Intervention model: Sequential Assignment
Intervention model description: 3-week, double-blind, placebo-controlled, 3 × crossover efficacy phase followed by 12 week open label phase, followed by 36 week open continuation phase
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Usability Study to Assess the Reveal LINQ Insertable Cardiac Monitor System
Condition: Syncope; Recurrent Symptomatic Atrial Fibrillation
MeSH terms: Syncope; Atrial Fibrillation
Study type: Interventional

Summary: 
      The purpose of the Reveal LINQ Usability Study is to assess the functionality of the Reveal
      LINQ insertable cardiac monitor and accompanying system in patients indicated for an
      insertable cardiac monitor
    

Detailed description: 
      The Reveal LINQ Usability Study is a prospective, non-blinded, non-randomized, multi-center
      clinical trial. Subjects will transmit device data via manual interrogation on a weekly basis
      during the first month and will be evaluated in the office at 1-month post-implant, in
      addition to an automatic nightly wireless data transmission using the MyCareLink® home
      monitor. All subjects will be requested to wear an external Holter for 48 hours at
      approximately 4 weeks post-insertion. Follow-up visits will continue at 6 and 12 months
      post-implant, with monthly manual interrogations. Subjects will be exited at their 12 month
      follow-up visit. The overall study will be conducted in 2 phases which differ primarily on
      inclusion criteria: Phase I subjects (initial 30 subjects) will have any indication for an
      ICM, Phase II subjects (all subjects following the initial 30 subjects) will be atrial
      fibrillation (AF) pre-ablation patients. The study will assess functionality of the Reveal
      LINQ device by assessing sensing performance and data transmission.
    

Intervention name(s): Insertable Cardiac Monitor Implant
Intervention type(s): Device
Intervention description(s): The Reveal LINQ is a leadless device that is recommended to be implanted in the region of the thorax. Two electrodes on the body of the device continuously monitor the patient's subcutaneous ECG. The device stores ECG recordings from the patient-activated episodes and ECG recordings from automatically detected arrhythmias. Documentation of episode occurrence will be retained.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
The Effect of Probiotics on Maintenance of Health in Pregnancy and Infants
Condition: Pregnancy
Study type: Interventional
Phase: Phase 2

Summary: 
      This phase 2 study evaluates the effect of perinatal use of probiotics on the number of
      diagnosed viral, bacterial and fungal infections in pregnant women and on the maintenance of
      a health pregnancy. In addition, the effect of probiotics intake during pregnancy and
      breastfeeding on the infant's overall health status will be evaluated.
    

Detailed description: 
      Throughout pregnancy women undergo many biological changes, including alterations in their
      microbiota. These infections can exacerbate pregnancy complications and increase the risk of
      preeclampsia and preterm birth. The present study aims to evaluate the potential effects of
      perinatal use of probiotics on the number of diagnosed viral, bacterial and fungal infections
      in pregnant women and on the maintenance of a healthy pregnancy. Potential infections include
      but are not limited to influenza/colds, bacterial vaginosis, mastitis, candidiasis, urinary
      tract infection and gingivitis. Additionally, the benefits of probiotic intake by the mother
      on the infant during pregnancy and breastfeeding will be evaluated.
    

Intervention name(s): Probiotic; Placebo
Intervention type(s): Dietary Supplement; Other
Intervention description(s): Dosing regimen of one capsule daily for a maximum of 18 weeks; Dosing regimen of one capsule daily for a maximum of 18 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: probiotics; infections; bacterial vaginosis
Comparison of Efficacy and Safety of Insulin Detemir and NPH Insulin in Children and Adolescents With Type 1 Diabetes
Condition: Diabetes; Diabetes Mellitus, Type 1
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Interventional
Phase: Phase 3

Summary: 
      The trial is conducted in Europe and Middle East. The aim of the trial is to compare the use
      of Insulin Detemir once or twice daily combined with mealtime Insulin Aspart against that of
      NPH Insulin once or twice daily combined with mealtime Insulin Aspart. The trial involves
      children and adolescents with Type 1 Diabetes.
    


Intervention name(s): insulin detemir; insulin NPH; insulin aspart
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: Insulin; Insulin, Globin Zinc; Insulin Aspart; Insulin Detemir; Isophane Insulin, Human; Insulin, Isophane; Isophane insulin, beef
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Study Comparing Powered Ported Bone Marrow Aspiration Procedures to Manual Standard Bone Marrow Aspiration Procedures Using Healthy Volunteers
Condition: Healthy
Study type: Interventional

Summary: 
      This single center, randomized, controlled trial will compare the manual standard bone marrow
      aspiration device to the powered ported bone marrow aspiration device for use in the iliac
      crest in healthy adult volunteers. The study will compare the subjects' perceived level of
      pain, time to sample acquisition, and quality of specimen yield of these devices. To serve as
      their own control, each subject will receive bilateral bone marrow aspiration procedures
      using both the manual standard and powered ported devices.
    

Detailed description: 
      This single center, randomized, controlled trial will compare the manual standard bone marrow
      aspiration needle to the power ported aspiration needle for use in the posterior iliac crest
      of healthy volunteers for bone marrow aspiration specimen collection. The study will compare
      the quality of specimen yield of the devices, subject reported level of pain with needle
      insertion and aspiration, and time from needle/skin contact to needle insertion and to sample
      acquisition. Each subject will serve as his/her own control and will receive bilateral bone
      marrow aspiration procedures using both the manual standard and power ported needles. The
      order in which the devices are used for each subject's procedures and on which side each
      device will be used will be randomized.
    

Intervention name(s): Jamshidi Manual Standard Device; OnControl Powered Ported Device
Intervention type(s): Device; Device
Intervention description(s): Jamshidi Manual Standard Device; OnControl Powered Ported Device
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Aspiration Procedures; Bone Marrow; To compare powered ported bone marrow aspiration procedures to manual standard bone marrow aspiration procedures
Reducing the Duration of Untreated Psychosis
Condition: First Episode Psychosis
MeSH terms: Psychotic Disorders; Mental Disorders
Study type: Observational

Summary: 
      The study examines the possible effect of a community campaign to decrease the duration of
      untreated psychosis in persons with their first episode of a psychotic disorder.
    

Detailed description: 
      The study examines whether a community campaign can reduce over time the duration of
      untreated psychosis (DUP) among persons with first episode psychosis (FEP). The DUP of mental
      health patients with FEP who sought services at a public outpatient or an inpatient facility
      was assessed for a 15 month period prior to the campaign launch. This serves as the baseline
      or historical control. The DUP will continue to be assessed for another 3 years. The
      hypothesis being tested is that there will be a significant decrease in DUP between baseline,
      one-year, two-year and three-year follow-ups. This study is being carried out with Latinos in
      Los Angeles County because as a group, particularly among Spanish-speaking immigrants,
      Latinos are at high risk for prolonged DUP.
    

Intervention name(s): Community Campaign La CLAVE
Intervention type(s): Other
Intervention description(s): A community campaign to teach community residents and professional networks the signs and symptoms of psychosis using social media, community talks, and advertising.
Observational model: Ecologic or Community
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Living in the catchment area of San Fernando Mental Health Outpatient clinic, a clinic with
        the Los Angeles County Department of Mental Health
A Study of Continuous Endostar Intravenous Infusion Combined With Pemetrexed and Carboplatin in Advanced Non Small Cell Lung Cancer Patients
Condition: Non-Small Cell Lung Cancer
MeSH terms: Lung Neoplasms; Carcinoma, Non-Small-Cell Lung
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is to evaluate the safety, tolerability, clinical efficacy and pharmacokinetics of
      continuous Endostar intravenous infusion combined with pemetrexed and carboplatin in advanced
      non small cell lung cancer (NSCLC) patients.
    


Intervention name(s): Carboplatin; Pemetrexed; Endostar; Centrum
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): d1, AUC 5, i.v.; d1, 500 mg/m2, i.v.; d2-d21, continuous Endostar intravenous infusion, 7.5 mg/m2/d, 15 mg/m2/d or 30 mg/m2/d, etc.; 1 tablet/day
Intervention MeSH terms: Carboplatin; Pemetrexed; Endostar protein
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Endostar; Carboplatin; Pemetrexed; NSCLC; Phase I
Exploratory Study to Evaluate Uncorrected Distance Vision and Quality of Vision After Light Treatments of an Implanted RxSight Light Adjustable Lens (RXLAL) With The Light Delivery Device (LDD) in Subjects With Preoperative Corneal Astigmatism
Condition: Aphakia; Cataract
MeSH terms: Cataract; Astigmatism; Aphakia
Study type: Interventional

Summary: 
      The objective of this study is to evaluate uncorrected distance vision and quality of vision
      as measured by the McAlinden QoV questionnaire 3 months following the final lock-in treatment
      of the implanted RxSight Light Adjustable Lens (RxLAL) with the Light Delivery Device (LDD)
      in subjects with preoperative keratometric astigmatism. This is an exploratory study. No
      primary effectiveness endpoints will be defined.
    


Intervention name(s): Light Adjustable lens (LAL) and Light Delivery Device (LDD)
Intervention type(s): Device
Intervention description(s): Primary and Fellow eyes will receive Light adjustable lens with Light delivery Device treatments
Intervention model: Single Group Assignment
Intervention model description: All subjects will receive the same treatment; however, each subject will have their eyes randomized to primary or fellow assignment. If only one eye of a patient meets study eligibility, that eye will automatically be designated as the primary eye.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Light Adjustable Lens; Intraocular lens; LAL
Efficacy of RTS,S/AS01 Vaccine Against Episodes of Malaria Due to P. Falciparum Infection in Children.
Condition: Malaria
MeSH terms: Malaria
Study type: Interventional
Phase: Phase 2

Summary: 
      This phase IIb trial is being done to find out if the RTS,S/AS01 vaccine helps to prevent
      children from falling ill with malaria and to evaluate vaccine safety.

      The Protocol Posting has been updated in order to comply with the FDA Amendment Act, Sep
      2007.
    


Intervention name(s): GSK malaria vaccine 257049 Vaccine; Sanofi-Pasteur's Human Diploid Cell Rabies Vaccine
Intervention type(s): Biological; Biological
Intervention description(s): 3 dose intramuscular injection; 3 dose intramuscular injection
Other intervention name(s): RTS; S/AS01E vaccine
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Malaria; Plasmodium; RTS; S/AS01; Falciparum
Study of the Reversibility of Vigilance Dysfunction at 6 Months of Continuous Positive Airways Pressure (CPAP) in Patients With Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)
Condition: Vigilance Dysfunction
Study type: Interventional

Summary: 
      It is a monocentric prospective pilot study in Poitiers University Hospital, specifically
      analyzing the vigilance disorders in the Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)
      and their reversibility after 6 months of Continuous positive airways pressure (CPAP).

      All subjects were administered a test of vigilance (Test of Attentional Performance) both
      before and after the 6 months of CPAP.

      The main objective is the study of the reversibility of alertness disorders on the number of
      omissions in the subtest visual vigilance of the TAP ( (Test of Attentional Performance) at 6
      months of CPAP in the OSAHS in patients with a memory complaint.
    


Intervention name(s): tests of attentional performance
Intervention type(s): Diagnostic Test
Intervention description(s): tests of attentional performance before and after 6 months of continuous positive airways pressure
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Effect of Food on the Pharmacokinetics (PK) of Emraclidine in Healthy Adult Participants
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary purpose of this study is to evaluate the effect of food (a high-fat meal) on the
      pharmacokinetics of emraclidine and metabolite CV-0000364 following single oral dose
      administration in healthy adult participants.
    


Intervention name(s): Emraclidine
Intervention type(s): Drug
Intervention description(s): Tablets
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Validation of a Lung Inflammation Model in Healthy Volunteers by Radiological Tools and Glucocorticoid Treatment
Condition: Experimental Lung Inflammation
MeSH terms: Pneumonia; Inflammation
Study type: Interventional

Summary: 
      The purpose of this study is to investigate the local and systemic inflammatory response and
      haemostatic alterations in the lungs after lipopolysaccharide (LPS) instillation and to
      determine the feasibility of imaging techniques to quantify lung inflammation in an adapted
      human endotoxin instillation model.

      The investigators will also explore whether glucocorticoid treatment can blunt LPS effects.
    


Intervention name(s): Dexamethasone; Sterile isotonic saline
Intervention type(s): Drug; Drug
Intervention description(s): Two doses of 40mg dexamethasone (in 100 ml physiologic saline solution, respectively) will be administered intravenously prior to LPS instillation.; two doses of 100 ml physiologic saline solution will be administered intravenously prior to LPS instillation.
Intervention MeSH terms: Dexamethasone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science