Effects on Cardiovascular Risk Factors of the Endogenous Hydroxytyrosol Generation After the Combined Intake of Wine and Tyrosol in Humans
Condition: Cardiovascular Disease
MeSH terms: Cardiovascular Diseases
Study type: Interventional

Summary: 
      The present study will assess whether the beneficial effects of a market moderate-alcohol
      drinking in the form of white wine in humans could be derived from the endogenous formation
      of hydroxytyrosol (also known DOPET), a potent dietary anti-inflammatory and antioxidant
      molecule.
    

Detailed description: 
      Epidemiological studies support that light to moderate alcohol drinking (10-20g per day), may
      reduce the risk of cardiovascular disease (CVD), stroke, dementia, depression, and all-cause
      mortality. In addition, moderate red wine consumption has recently shown to be inversely
      associated with a decline in global cognitive function and the domains of memory and
      flexibility. The claimed beneficial effects of the Mediterranean diet include prevention of
      several age-related dysfunctions including cardiovascular and neurodegenerative diseases.
      These effects have been related to the protection against cognitive decline associated with
      aging and disease by a number of polyphenols found in red wine and virgin olive oil.
      Neurodegenerative diseases, as all chronic degenerative diseases, are linked to inflammation
      and its inter-twined phenomena: the oxidation and the oxidative damage. The interrelationship
      among chronic degenerative diseases is also evidenced by the fact that vascular
      (cardiovascular) risk factors are associated to cognitive decline, and these vascular factors
      are currently the only known modifiable risk factors for Alzheimer disease.

      There is evidence suggesting that DOPET, also known as hydroxytyrosol (HOTYR), has a role in
      the cardioprotective and neuroprotective properties of wine. It is a phenolic compound
      present in virgin olive oil and wine, and it is a potent dietary anti-inflammatory and
      antioxidant molecule. Biological effects of HOTYR may explain in part some of the beneficial
      effects for human health that have been credited to moderate ethanol intake (in form of
      wine).

      The present project is not intended to provide support for the clinical use of moderate- dose
      alcohol as a treatment modality for CVD risk patients. Nevertheless, it will investigate a
      novel mechanism of action that may explain in part beneficial health effects associated to
      moderate alcohol consumption. This novel mechanism of action is mediated by compounds that at
      mid/long-term run are susceptible of a pharmaceutical and/or nutraceutical food development.
    

Intervention name(s): white wine; tyrosol
Intervention type(s): Other; Dietary Supplement
Intervention description(s): A dietary beverage: a market white wine, 13º alcohol; tyrosol in capsules
Intervention MeSH terms: 4-hydroxyphenylethanol
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Endothelial function; Inflammation; Genes related to vascular risk