bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Progressive Resistance Training on Physical State Energy and Fatigue During Pregnancy.
Condition: Pregnancy Related
MeSH terms: Fatigue
Study type: Interventional

Summary: 
      The purpose of this study is to compare the effects of progressive resistance training on
      physical state energy and fatigue during pregnancy. This study was a randomized controlled
      trial used to find the effects of progressive resistance training on physical state energy
      and fatigue during pregnancy. The data was collected from Sheikh Zaid Hospital via Visual
      analogue scale-fatigue, Numeric pain rating scale and Short form health survey-36. Sample
      size of 30 females was taken in 15 each group.
    

Detailed description: 
      According to the findings of a study on physical activity during pregnancy in 2021, obese
      women, who exercise less than ladies of normal body weight may gain from gradually increasing
      their amount of exercise to reduce the amount of weight gain associated with pregnancy.
      Exercise during pregnancy was consistently associated positively with sob-R among the women
      in both categories, which denotes that it may have an impact on the control of lepton
      activity and pregnancy-induced insulin resistance. Overall, our research suggests that obese
      women, who are lepton-resistant and at pregnant women at high risk of gestational diabetes,
      fast weight gain, and increased fetal adiposity should receive advice and supportive services
      to raise their activity level, with an emphasis on the fact that even slight improvements in
      action can be good for both child and maternal health.
    

Intervention name(s): progressive resistant exercises
Intervention type(s): Other
Intervention description(s): Group A (Experimental Group):
• Warm up Exercise + stretching Exercise (upper and lower extremity) + progressive resistance exercises Warm up Exercise (for 5 min) Stretching (upper and lower extremity)
3. Progressive Resistance exercises:
Leg press :( dual leg press): Leg press target the
"Quadriceps" or quads .but they also work your "Hamstrings".
Leg curls (dual leg curls):
Leg curls Target the "hamstrings" and "Calf" muscles Leg Extension
The Muscles worked:
Rectus femoris
Vastus lateralis
Vastus medialis
Vastus intermedius
4. Arm lat pull (dual arm lat pull):
Back extension (lumber extension):
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Energy state; Fatigue; Pregnancy; Muscle stretching exercises
Carbohydrates to Prevent Hypoglycaemia During Physical Activity in Patients With Type 1 Diabetes
Condition: Hypoglycaemia
MeSH terms: Hypoglycemia
Study type: Interventional

Summary: 
      Backgrounds/Aims: It was the aim to prospectively study the optimum regime of "preventive"
      carbohydrate administration for prevention of hypoglycaemic episodes during a standardized
      bout of physical activity.
    

Detailed description: 
      Research design and methods: 24 patients with type 1 diabetes participated in one experiment
      without physical activity and in three experiments with a 4 km, 60 min hike starting at 2
      p.m., either administering 2 x 10 g or 2 x 20 g carbohydrates (muesli bars) before starting
      and at 30 min (during the hike). Plasma glucose was determined with a laboratory method and
      additional carbohydrates needed to treat hypoglycaemia between 2 and 8 p.m. were recorded.
    

Intervention name(s): low amount of carbohydrates; high amount of carbohydrates; Rapid-acting carbohydrates
Intervention type(s): Other; Other; Other
Intervention description(s): different regimens of carbohydrate administration to prevent hypoglycaemia during a standardized bout of moderate physical activity in patients with type 1 diabetes; different regimens of carbohydrate administration to prevent hypoglycaemia during a standardized bout of moderate physical activity in patients with type 1 diabetes; different regimens of carbohydrate administration to prevent hypoglycaemia during a standardized bout of moderate physical activity in patients with type 1 diabetes
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: carbohydrate, hypoglycemia
Acoustic Radiation Force Impulse-Imaging in Comparison to Transient Elastography for Liver Fibrosis Staging in HCV
Condition: Chronic Hepatitis C
MeSH terms: Hepatitis C; Hepatitis C, Chronic; Hepatitis; Hepatitis, Chronic; Liver Cirrhosis
Study type: Interventional

Summary: 
      This study will evaluate the effectiveness of Acoustic Radiation Force Impulse (ARFI)-
      Imaging compared to Transient Elastography (FibroScan) in differentiating liver fibrosis in
      patients with chronic hepatitis C. Patients who are scheduled to have a liver biopsy will
      also undergo ARFI and FibroScan testing. The liver biopsy will be used as the reference
      method. The target sample size is 433.
    


Intervention name(s): FibroScan; Acoustic Radiation Force Impulse (ARFI)- Imaging
Intervention type(s): Device; Device
Primary purpose: Diagnostic
Chiropractic for Back and Neck Pain in an Emergency Department Setting
Condition: Back Pain; Neck Pain; Anxiety
MeSH terms: Back Pain; Emergencies; Neck Pain
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This study aims to examine the efficacy of an Integrative approach utilizing Chiropractic as
      an add-on therapy for the treatment back and neck pain in an emergency department setting

      Chiropractic is well established as an effective treatment for back pain. The investigators
      cumulative experience in Asaf Harofeh Medical Center has shown Chiropractic to be an
      effective therapy for simple back and neck pain in an emergency room (ER) setting.

      This study will examine weather Chiropractic can decrease pain, increase range of motion and
      decrease anxiety in patients admitted to the Emergency Room with simple back and neck pain
      without neurological findings. Chiropractic will be performed as an add on therapy on top of
      analgesic therapy.
    


Intervention name(s): real chiropractic; Sham Chiropractic
Intervention type(s): Procedure; Procedure
Intervention description(s): real chiropractic manipulation; Placebo stimulation using 'activator' thumper
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: back pain; neck pain; anxiety; range of motion
Antioxidants in Gestational Diabetes
Condition: Gestational Diabetes Mellitus
MeSH terms: Diabetes, Gestational; Diabetes Mellitus
Study type: Interventional
Phase: Phase 4

Summary: 
      Fasting and two hours postprandial blood sugar were done to all cases between 28 and 32 weeks
      and high blood sugar levels were found so Cases were controlled by both diet and insulin.

      The 200 pregnant women with Gestational diabetes mellitus were randomized using automated web
      based randomization system into 2 groups, Group1 received 1 gram L-ascorbic acid (vitamin C
      )per day from the time of diagnosis until the time of delivery in addition to routine
      treatment of diabetes (diet & insulin). Group2 received only the treatment of diabetes
    

Detailed description: 
      The 200 pregnant women with Gestational diabetes mellitus were randomized using automated web
      based randomization system into 2 groups, Group1 received 1 gram L-ascorbic acid oral once
      daily (vitamin C )per day from the time of diagnosis until the time of delivery in addition
      to routine treatment of diabetes (diet & insulin). Group2 received only the treatment of
      diabetes (diet and insulin
    

Intervention name(s): L-ascorbic acid
Intervention type(s): Drug
Intervention description(s): 1 gram L-ascorbic acid (vitamin C …..) per day from the time of diagnosis until the time of delivery
Other intervention name(s): vitamin C
Intervention MeSH terms: Ascorbic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: antioxidants; Gestational diabetes mellitus; oxidative stress
Ability to Cope With Type 1 Diabetes
Condition: Depression
MeSH terms: Diabetes Mellitus, Type 1; Depression
Study type: Observational

Summary: 
      The purpose of this study is to learn about the relationship that exists between coping
      skills and blood glucose control. In addition to this, we will study the effect of type 1
      diabetes on coping skills in different age groups, genders, ethnicities, socioeconomic
      groups, and the duration of diabetes.
    

Detailed description: 
      Coping with type 1 diabetes can be very difficult. Type 1 diabetes is a very unique chronic
      disease because it requires constant attention to several responsibilities such as daily
      glucose monitoring, multiple daily insulin doses, and strict diet and exercise. Several
      studies have shown that increased rates of poorer glucose control are a result of struggling
      to cope with type 1 diabetes. This may be due to the fact that many type 1 diabetics
      experience a feeling of exhaustion, or "burnout," after a certain period of time due to an
      overwhelming amount of responsibility.

      In our study we would like to determine how children's ability to cope with diabetes affects
      glucose control. By completing several questionnaires, we can analyze different kinds of
      coping skills through a complex scoring system. These scores will then be analyzed in
      comparison to your glucose control using HbA1c.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients of diabetes clinic, Texas Children's Hospital.
      
Keywords: Depression; Socioeconomic status; Type 1 diabetes mellitus; Children; Adolescents
Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF
Condition: Ectopic Pregnancy
MeSH terms: Pregnancy, Ectopic; Cardiac Complexes, Premature
Study type: Observational

Summary: 
      This study evaluates the increased risk of ectopic pregnancy associated with marked variation
      of estradiol during the early luteal phase and high progesterone on hCG day in IVF.
    

Detailed description: 
      This is a retrospective cohort study of 578 patients who had no risk of EP (672 fresh
      transfer IVF cycles) between January 2005 and December 2014. Few studies have reported the
      relation between hormonal levels and ectopic pregnancy (EP) in IVF. Investigators describe EP
      incidence according to estradiol (E2) and progesterone (P4) levels on hCG day and seven days
      later (hCG+7) or their variation between both days.
    

Intervention name(s): Analysis of Ectopic Pregnancy incidence
Intervention type(s): Other
Intervention description(s): Collect retrospectively data. Analysis of Ectopic Pregnancy incidence through Estradiol (E2) and progesterone (P4) levels on hCG day and seven days later (hCG+7)
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Patients who had no risk of EP (672 fresh transfer IVF cycles) between January 2005 and
        December 2014.
Comparison of Efficacy of Paravertebral and Epidural Analgesia After Videothoracoscopic Lung Lobectomy
Condition: Lung Cancer
Study type: Interventional
Phase: Phase 2

Summary: 
      Thoracic surgery correlates with significant pain in postoperative period. In order to
      alleviate the pain various combinations of pharmaceuticals and administration methods are
      employed. So as to reduce the extent of surgical trauma and, consequently, correlated pain
      various operation techniques are used. In traditional thoracotomy epidural anesthesia remains
      a golden standard. Epidural anesthesia however demands high skills to be performed correctly
      and presents an increased risk of grave complications. In videothoracoscopic (VATS)
      operations paravertebral blockade can be employed, yet there is no certainty if its efficacy
      after lung lobectomy. We therefore designed a prospective, randomized, parallel group, single
      site study to test the hypothesis, that continuous paravertebral blockade is as efficient in
      postoperative pain reduction as continuous epidural blockade and possesses a higher safety
      profile.
    


Intervention name(s): Continuous Thoracic Epidural Block; Continuous Thoracic Paravertebral Block; Patient-Controlled Analgesia with Morphine
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): Before anesthesia, continuous thoracic epidural block of T5/T6 is performed (Portex Epidural Minipack set). Identification of paravertebral space by loss of resistance technique (air). A catheter is advanced ca. 3-5 cm, and test dose with 2 ml of lidocaine 2% i injected. At the end of surgery syringe with 0,25% bupivacaine with epinephrine 1:200.000 is connected to catheter and 6 ml bolus is injected, followed by an infusion of the same mixture at 0,06 ml/kg/h for postoperative pain management.; Before anesthesia, continuous thoracic paravertebral block of T5/T6 is performed (Portex Epidural Minipack set). Identification of paravertebral space by loss of resistance technique (normal saline). After injection of 5-10 ml of normal saline a catheter is advanced medially ca. 5 cm. At the end of surgery syringe with 0,25% bupivacaine with epinephrine 1:200.000 is connected to catheter and 20 ml bolus is injected, followed by an infusion of the same mixture at 0,08 ml/kg/h for postoperative pain management; Once arrived at the PACU all patients are placed on a postoperative analgesia regimen, that include:
patient-controlled analgesia with morphine (bolus dose 2 mg, lockout time 10 min)
paracetamol 1000 mg iv every 8 hrs
ketoprofen 100 mg iv every 12 hrs
Intervention MeSH terms: Morphine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: paravertebral block; thoracic epidural analgesia; videothoracoscopic surgery; lung lobectomy
Study of INS115644 Ophthalmic Solution in Subjects With Ocular Hypertension or Glaucoma
Condition: Ocular Hypertension; Open Angle Glaucoma
MeSH terms: Glaucoma; Glaucoma, Open-Angle; Ocular Hypertension; Hypertension
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this trial is to evaluate the safety and tolerability of INS115644 Ophthalmic
      Solution in subjects with bilateral ocular hypertension or early primary open angle glaucoma
      and to investigate the intraocular pressure lowering effects of INS115644 Ophthalmic
      Solution.
    


Intervention name(s): INS115644 Ophthalmic Solution; Placebo; INS115644 Ophthalmic Solution; INS115644 Ophthalmic Solution; INS115644 Ophthalmic Solution
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): One drop of Concentration #1 in one eye and one drop of placebo in contralateral eye every 12 hours for three days; One drop of placebo in each eye every 12 hours for three days; One drop of Concentration #2 in one eye and one drop of placebo in the contralateral eye every twelve hours for three days; One drop of Concentration #3 in one eye and one drop of placebo in the contralateral eye every twelve hours for three days; One drop of Concentration #4 in one eye and one drop of placebo in the contralateral eye every twelve hours for three days
Intervention MeSH terms: Pharmaceutical Solutions; Ophthalmic Solutions
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Bilateral ocular hypertension or early primary open angle glaucoma
TDN, Manual Therapy and Exercise For the Management of Achilles Tendinopathy
Condition: Achilles Tendon Injury
MeSH terms: Tendinopathy; Tendon Injuries
Study type: Interventional

Summary: 
      Conflicting evidence exists regarding the recommendations from the Orthopaedic section of the
      American Physical Therapy Association for treatment of Achilles tendinitis. Trigger point dry
      needling is effective in reducing pain in several body regions, but no published (TDN)
      studies are found reporting the effect on Achilles tendinopathy. The purpose of this study is
      to investigate whether a treatment program performed including TDN, manual therapy and
      exercise will result in a significant improvement in pain, strength and function compared to
      a treatment program including manual therapy and exercise for Achilles tendinopathy. Subjects
      with Achilles tendinopathy that receive treatment including TDN, manual therapy and exercise
      will demonstrate a significant improvement in pain, strength and functional outcomes compared
      to the group that receives manual therapy and exercise.
    

Detailed description: 
      This study is a randomized controlled trial, pretest-posttest control group design comparing
      the effect of TDN, manual therapy and exercise to manual therapy and exercise on human
      subjects with Achilles tendinopathy following eight treatments in four weeks and a follow up
      examination at three months.
    

Intervention name(s): manual therapy and exercise; trigger point dry needling
Intervention type(s): Procedure; Procedure
Intervention description(s): soft tissue mobilization, stretches, concentric and eccentric strengthening; trigger point dry needling to trigger points located in the gastrocnemius, soleus and tibialis posterior
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Impact of the Introduction of ORKAMBI on Anxiety, Depression, Quality of Life and Adherence of Adolescents and Young Adults
Condition: Cystic Fibrosis
MeSH terms: Cystic Fibrosis; Fibrosis; Depression
Study type: Observational

Summary: 
      The aim of this project is to evaluate the psychological reshuffle induced by ORKAMBI. The
      particular focus of this study is the consequence of its introduction on anxiety, depression,
      quality of life and adherence to all cystic fibrosis (CF) treatment. To answer this question
      investigators will monitor the psychological function of CF adolescents and young adults
      treated with ORKAMBI and compare them to CF adolescents and young adults not treated with
      ORKAMBI.
    

Detailed description: 
      Introduction of KALYDECO then ORKAMBI, as a personalized medicine in the therapeutic strategy
      of Cystic Fibrosis (CF) may deeply modify the prognosis of patients with CF. These approaches
      realize the dream of short-circuiting the molecular mechanism of the disease and therefore
      opens the perspective of an extended and functional survival. It suddenly offers the
      possibility of a completely new future to the patient and his family, and therefore must
      deeply impact on the psychological function of all involved. Moreover, those new therapies
      may also modify the adherence to CF basic treatment, as it brings a new feeling of good
      health and the hope of a longer life. For that reason there is a need to investigate
      modifications of the psychological state of mind induced by the treatment with ORKAMBI in CF
      adolescents and young adults.

      This project aims to understand the psychological impact and to study the consequences of the
      introduction of ORKAMBI on adherence to CF treatment, anxiety, depression and quality of
      life.

      To answer this question, investigators will evaluate the psychological function of
      adolescents and young adults, aged 12 to 20 years, with CF treated with ORKAMBI, and compare
      it to other adolescents and young CF adults not treated with ORKAMBI.

      This is a cohort prospective study, with a 1 year follow-up.
    

Intervention name(s): Questionnaires
Intervention type(s): Behavioral
Intervention description(s): Answering 4 questionnaires : anxiety, depression, quality of life and adherence
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        CF Center patients
      
Keywords: Cystic Fibrosis; Orkambi; Adherence; Adolescent; Anxiety; Depression; Psychology
Development of Ivermectin for Alcohol Use Disorders
Condition: Alcohol Use Disorder
MeSH terms: Alcoholism; Alcohol Drinking
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Current pharmacotherapies for alcohol use disorders (AUDs) have limited efficacy. Thus, the
      development of effective treatments for AUDs represents an important public health objective.
      Repositioning, i.e. using existing approved drugs for other indications, represents a fast
      and economically feasible approach for drug development. Ivermectin (IVM) is an FDA-approved
      antiparasitic medication that can significantly reduce alcohol intake in mice, suggesting
      that it may be useful in the treatment of AUDs in humans. The goal of this project is to
      provide key clinical evidence that IVM can be repositioned as a novel therapeutic agent to
      treat AUDs.
    

Detailed description: 
      Current pharmacotherapies for alcohol use disorders (AUDs) have limited efficacy. Thus, the
      development of effective treatments for AUDs represents an important public health objective.
      Repositioning, i.e. using existing approved drugs for other indications, represents a fast
      and economically feasible approach for drug development. Ivermectin (IVM) is an FDA-approved
      antiparasitic medication that can significantly reduce alcohol intake in mice, suggesting
      that it may be useful in the treatment of AUDs in humans. The goal of this project is to
      provide key clinical evidence that IVM can be repositioned as a novel therapeutic agent to
      treat AUDs. We will enroll 10 alcohol dependent individuals in a placebo-controlled
      randomized pilot safety trial of IVM (30 mg orally once) over a 2-day (1-night) inpatient
      stay at the UCLA CTRC and employ a well-characterized battery of behavioral paradigms (i.e.,
      alcohol administration and cue exposure). The goals of the study are to test: (a) the safety
      of combining IVM, at a dose currently shown to be safe in humans (30 mg), with moderate doses
      of alcohol (0.08 g/dl); and (b) whether IVM reduces the reinforcing effects of alcohol during
      alcohol administration and whether it reduces alcohol craving during cue exposure, as
      compared to placebo.
    

Intervention name(s): Ivermectin; Placebo; Alcohol
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Ivermectin is a semi-synthetic macrocyclic lactone used worldwide as a broad-spectrum antiparasitic avermectin.; Matched placebo
Other intervention name(s): Stromectol; Sugar pill; 5% ethanol IV solution
Intervention MeSH terms: Ethanol; Ivermectin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: ivermectin, alcoholism, alcohol use disorder, treatment