bioihbjkbjnl/mcl2 huggingface dataset:
Carpal Tunnel Syndrome: Case Reports and Analysis - Ultrasound Imaging and Pathomechanics of Median Nerve Compression
Condition: Carpal Tunnel Syndrome
MeSH terms: Carpal Tunnel Syndrome; Syndrome
Study type: Observational

Summary: 
      Carpal tunnel syndrome is caused by compression of the median nerve at the wrist. The
      hypothesis is that ultrasound imaging can be used to visualize nerve compression in carpal
      tunnel patients during hand activity, and normal subjects will not demonstrate any nerve
      compression.
    

Detailed description: 
      Two patients with carpal tunnel syndrome underwent nerve testing to document that they had
      median nerve abnormality at the wrist. They subsequently had ultrasound imaging of the wrist
      at rest and during a stress test using hand activity. Two control subjects had nerve testing
      to prove that they had no nerve abnormality at the carpal tunnel. The carpal tunnel syndrome
      patients demonstrated nerve compression on the ultrasound images during the stress tests and
      the normal subjects showed no nerve compression.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Adult patients with upper extremity symptoms of pain, numbness, and tingling; Adult
        subjects with no upper extremity pain, numbness, or tingling
      
Keywords: carpal tunnel syndrome; median nerve; ultrasound; electrodiagnosis; Normal subjects
Effect of Hyperoxemia on Platelet Function in Healthy Volunteers
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 4

Summary: 
      Prospective, controlled, randomized crossover volunteer study to investigate the effect of
      hyperoxemia due to inhalation of oxygen (80% inspiratory fraction) via reservoir-face-mask on
      blood coagulation, especially platelet function, as measured by thrombelastography. According
      to results of basic animal and in vitro investigations, hyperoxemia may activate platelets by
      means of reactive oxygen species. This study aims at investigating a possible pro-coagulant
      effect of hyperoxemia in healthy volunteers. Additional studies on possible mechanisms are
      integrated.

        -  Trial with medical device
    


Intervention name(s): oxygen inhalation
Intervention type(s): Drug
Intervention description(s): Inhalation of 80% oxygen via face mask
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Superficial Cervical Plexus Block for Postoperative Chronic Pain
Condition: Neurosurgery
MeSH terms: Chronic Pain
Study type: Interventional

Summary: 
      The incidence of postoperative chronic pain after craniotomy is high. Postoperative chronic
      pain seriously affects patient's quality of life. Compound local scalp nerve block is a good
      choice for analgesia after craniotomy. However, the scalp nerve block commonly cannot cover
      the area of suboccipital retrosigmoid approach craniotomy, leading to incomplete block.
      Superficial cervical plexus block (SCPB) is theoretically promising to solve the analgesia
      requirements of such surgical approach. At the same time, ultrasound guidance can not only
      accurately locate, ensure the effect of block and avoid accidental injury during puncture.
      The purpose of this study is to explore whether ultrasound-guided superficial cervical plexus
      block can safely and effectively reduce the incidence of chronic pain after craniotomy via
      suboccipital retrosigmoid approach.
    


Intervention name(s): Superficial cervical plexus block; Control group
Intervention type(s): Procedure; Other
Intervention description(s): Ultrasound guidance will be used to determine the location of superficial cervical plexus nerve. The puncture will also be performed by ultrasound guidance, covered with opaque infusion dressing but performed with infusion of 10 ml 0.5% ropinacaine.; Ultrasound guidance will be used to determine the location of superficial cervical plexus nerve. The puncture will also be performed by ultrasound guidance, covered with opaque infusion dressing but performed with infusion of 10 ml normal saline.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Cervical Plexus Block; Chronic pain; Neurosurgery
Pain, Acceptance, and Discomfort With Periodontally Accelerated Osteogenic Orthodontics (PAOO)
Condition: Crowding of Anterior Mandibular Teeth
Study type: Observational

Summary: 
      Patients will be examined in the Orthodontic Department of the University of Damascus Dental
      School. Patients who will be treated in conjunction with the PAOO procedure and subjects who
      will meet the inclusion criteria will be included then the initial diagnostic records
      (diagnostic gypsum models, internal and external oral photographs, as well as radiographic
      images) will be studied to ensure that the selection criteria will be accurately matched.
      This study aims to assess patients' acceptance of the PAOO procedure as well as the levels of
      pain and discomfort associated with this treatment.
    

Detailed description: 
      Surgical procedure associated with PAOO The surgery will be performed under local anesthesia
      and then full-thickness flaps will be reflected labially only from the distal surface of the
      lower right canine to the distal surface of the lower left canine, after washing the exposed
      alveolar bone with saline, then a selective cortical cutting will be performed using a
      piezosurgery and then the Bone-D® xenograft (particle size of 0.2 mm-1.0 mm) from Medpark
      (Busan, Korea) will be placed, then the wound will be sutured. Then a schedule will be set up
      to review the patient after 1, 7, 14, and 28 days to fill out questionnaires related to pain,
      acceptance, discomfort, satisfaction, and follow-up to orthodontic treatment.
    

Intervention name(s): Periodontally Accelerated Osteogenic Orthodontics (PAOO)
Intervention type(s): Procedure
Intervention description(s): Fixed appliance will be placed for every patient, then surgical procedure will be applied after reflecting a full-thickness labial flap.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients with malocclusion

          1. Crowding on the lower arch with a moderate degree (i.e., between 4 to six millimeters
             of a tooth-size-arch-length discrepancy).

          2. Class I malocclusion

          3. With no severe skeletal discrepancy.
      
Keywords: Visual Analog Scale; Acceleration; moderate crowding
A Study to Evaluate Different Dose Levels of GlaxoSmithKline (GSK) Biologicals' Investigational Respiratory Syncytial Virus (RSV) Vaccine (GSK3888550A), Based on the Vaccine Safety and the Antibodies (Body Defences) Produced Following Vaccine Administration, When Given to Healthy Non-pregnant Women
Condition: Respiratory Syncytial Virus Infections
MeSH terms: Respiratory Syncytial Virus Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate different dose levels of the investigational RSV
      maternal vaccine (GSK3888550A) based on safety/reactogenicity and immune response data.

      As this is the first time the investigational RSV maternal vaccine (GSK3888550A) is being
      been used in humans, this study will be performed in healthy non-pregnant women 18-45 years
      of age before testing in pregnant women.
    

Detailed description: 
      Healthy non-pregnant women 18-45 years of age will be randomized in a 1:1:1:1 ratio to
      receive one of three dose levels (30, 60, 120 micrograms [µg]) of the investigational RSV
      maternal vaccine (GSK3888550A) or placebo, administered as a single intramuscular injection
      (IM).

      There will be a screening visit and five study visits scheduled at Day 1 (study vaccination),
      Day 8, Day 31, Day 61, and Day 91 to evaluate the primary and secondary objectives of
      safety/reactogenicity and immunogenicity profiles of the 3 dose levels. Subjects will also be
      contacted at Day 181. During this contact, the investigator (or delegate) will ask the
      subject if she has experienced any serious adverse events (SAEs) and or any adverse events
      (AEs) leading to study withdrawal since the last study visit (Day 360), as well as if she has
      become pregnant during the post-vaccination period. The investigator (or delegate) will also
      ask the subject about concomitant vaccinations/products/medications that she has received
      since the last study visit (D91). Contact should be performed preferably via telephone. Other
      means of contact (email/other) may be acceptable provided the required information can be
      fully collected.
    

Intervention name(s): GSK3888550A RSV Maternal vaccine formulation 1; GSK3888550A RSV Maternal vaccine formulation 2; GSK3888550A RSV Maternal vaccine formulation 3; Placebo (Normal Saline)
Intervention type(s): Biological; Biological; Biological; Drug
Intervention description(s): Single dose administered intramuscularly at Day 1 in the deltoid region of the non-dominant arm; Single dose administered intramuscularly at Day 1 in the deltoid region of the non-dominant arm; Single dose administered intramuscularly at Day 1 in the deltoid region of the non-dominant arm; Single dose administered intramuscularly at Day 1 in the deltoid region of the non-dominant arm
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Vaccines; Safety; Immunogenicity; Reactogenicity; Respiratory Syncytial Viruses
Adalimumab Biosimilar in Clinical Practice
Condition: Psoriasis
MeSH terms: Psoriasis
Study type: Observational

Summary: 
      This is an observational, retrospective, multicenter, and descriptive study of patients
      treated with adalimumab biosimilar for psoriasis, according to clinical practice.

      Existing data will be collected from the Dermatology Services database of the hospitals
      participating in the study, from the medical histories of all treated patients who meet the
      inclusion criteria and sign informed consent.

      The aim of the study is to determine the effectiveness of the different adalimumab
      biosimilars in clinical practice.
    

Detailed description: 
      Adalimumab is indicated for the treatment of moderate to severe chronic plaque psoriasis in
      adult patients who are candidates for systemic treatment. There are currently several
      biosimilar drugs (Amgevita, Imraldi, Hyrimoz, Idacio, Hulio,…) in addition to the reference
      product (Humira).

      The reduction in the cost of production of biosimilar drugs with respect to reference
      products has led to their replacement by biosimilar drugs in patients initiating biological
      therapy, but some centers are also switching to adalimumab biosimilar in patients who are
      controlled with original adalimumab (Humira).

      There are no actual clinical efficacy / safety data in our setting on the use of adalimumab
      biosimilars.

      There is also no evidence of maintenance response in patients who are switched from
      adalimumab (Humira) to biosimilar adalimumab in clinical practice.

      This retrospective study will collect demographic and disease data of the psoriasis patient
      treated with the different biosimilars of adalimumab, as well as their comorbidities,
      response to treatment, and safety. In this way, data will be available in usual clinical
      practice to improve the management of the patient with psoriasis treated with biosimilar
      drugs.
    

Intervention name(s): Adalimumab
Intervention type(s): Biological
Intervention description(s): Analysis of survival of adalimumab biosimilar in clinical practice
Intervention MeSH terms: Adalimumab
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with moderate-severe psoriasis vulgaris who are candidates for systemic treatment
        undergoing adalimumab treatment.
Long-term Study in Early Loaded Hydrophilic Surface Implants
Condition: Dental Implant
Study type: Observational

Summary: 
      Objective: To assess the clinical outcomes and patient satisfaction of early loaded implants
      with a hydrophilic, moderately rough surface for partially edentulous patients after a
      follow-up of 8.5 to 9.5 years.

      Materials and methods: A prospective observational single-centre study involving 15 patients
      with single, delayed placement and early loaded implants in the posterior area was performed.
      Clinical and radiographical parameters, including biological and technical complications and
      patient satisfaction, were assessed.
    


Intervention name(s): Dental implant (ELEMENT RC INICELL, Thommen Medical)
Intervention type(s): Device
Intervention description(s): Dental implant
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients treated in an University Clinic
      
Keywords: Dental implant; Implant crowns; Hydrophilic implant surface; Early loading; Late implant placement
Radicle Relief 1: A Study of Health and Wellness Products on Pain and Other Health Outcomes
Condition: Pain; Nociceptive Pain; Neuropathic Pain
MeSH terms: Neuralgia; Nociceptive Pain
Study type: Interventional

Summary: 
      A randomized, blinded, placebo-controlled study assessing the impact of health and wellness
      products on pain and other health outcomes
    

Detailed description: 
      This is a randomized, blinded, placebo-controlled study conducted with up to 300 adult
      participants per study arm, age 21 and older and residing in the United States.

      Eligible participants will (1) endorse a desire for less pain, (2) indicate an interest in
      taking a health and wellness product to potentially help relieve their pain, and (3) express
      acceptance in taking a product and not knowing its formulation until the end of the study.

      Participants with known liver or kidney disease, heavy drinkers, and those who report they
      are pregnant, trying to become pregnant, or breastfeeding will be excluded. Those taking
      certain medications will be excluded.

      Self-reported data are collected electronically from eligible participants over 5 weeks.
      Participant reports of health indicators will be collected during baseline, throughout the
      active period of study product use, and in a final survey. All study assessments will be
      electronic; there are no in-person visits or assessments for this real-world evidence study
    

Intervention name(s): Relief Study Product Usage
Intervention type(s): Dietary Supplement
Intervention description(s): Participants instructed to use study product daily as directed for a period of 4 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants will be stratified based on gender at birth then randomized to one of the study arms
Masking: Double (Participant, Investigator)
Primary purpose: Other
Glutamatergic and GABAergic Mediators of Antidepressant Response in Major Depression
Condition: MDD; Citalopram; Major Depressive Disorder
MeSH terms: Depressive Disorder; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 4

Summary: 
      Primarily, this study seeks to evaluate whether citalopram treatment is associated with an
      increase in the Glutamine (Gln)/Glutamate (Glu) ratio in the anterior cingulate cortex (ACC)
      from baseline to day 3 of treatment. Additionally, this study would like to examine whether
      citalopram treatment is associated with an increase in the Gln/Glu ratio in the ACC from
      baseline to day 7 of treatment. In order to more fully examine baseline neurochemical and
      functional abnormalities in participants with MDD, we also seek to scan a group of age- and
      sex-matched non-depressed comparison individuals in order to perform between-group analyses
      of baseline neuroimaging measures.
    

Detailed description: 
      Little is known about the acute effects of standard antidepressant treatments on brain
      glutamate and gamma-amino-butyric acid (GABA) levels, and their association with clinical
      response. In the current study, we used proton magnetic resonance spectroscopy (1H-MRS) to
      examine longitudinally the effects of citalopram on the glutamine/glutamate ratio and GABA
      levels in the pregenual anterior cingulate cortex (pgACC) - a region that has been repeatedly
      implicated in antidepressant response - of individuals with major depressive disorder (MDD).
      We acquired 1H-MRS scans at baseline and at days 3, 7, and 42 of citalopram treatment in
      nineteen unmedicated individuals with MDD. Ten age- and sex-matched non-depressed comparison
      individuals were scanned once and did not receive citalopram. The association between
      baseline metabolites and the change in metabolites from baseline to each time point and
      change in Montgomery-Åsberg Depression Rating Scale (MADRS) score from baseline to day 42 was
      assessed by longitudinal regression analysis, adjusting for age, sex, and baseline MADRS,
      using generalized estimating equations.
    

Intervention name(s): citalopram
Intervention type(s): Drug
Intervention description(s): citalopram 20-40 mg daily
Other intervention name(s): Celexa
Intervention MeSH terms: Citalopram
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Intervention model description: Open-label administration of citalopram to participants with major depressive disorder. MRI scans performed at baseline and days 3, 7, and 42. An age- and gender-matched group of healthy volunteers did not receive citalopram and received on MRI scan to perform between-group baseline analyses.
Masking: None (Open Label)
Primary purpose: Treatment
A Study of OV101 in Individuals With Angelman Syndrome (AS)
Condition: Primary Disease or Condition Being Studied: Angelman Syndrome (AS)
MeSH terms: Angelman Syndrome; Syndrome
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to assess the efficacy and safety of oral OV101 (gaboxadol) in
      pediatric subjects with Angelman syndrome.
    


Intervention name(s): Gaboxadol; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): OV101 versus placebo once daily at bedtime for 12 weeks; Matching placebo capsules to OV101 capsules.
Intervention MeSH terms: Gaboxadol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Effects of Thai Massage on Patients With Wrist Extensor Muscles Latent Myofascial Trigger Points
Condition: Patients With Latent Myofascial Trigger Point
Study type: Interventional

Summary: 
      The purpose of this study was to investigate the effect of Thai massage on pressure pain
      threshold, pain intensity, wrist range of motion, grip strength and patient satisfaction in
      patients with wrist extensor muscles latent Myofascial trigger points.
    


Intervention name(s): Thai massage
Intervention type(s): Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Role of Bladder Training During Post-operative Hospital Stay After Radical Hysterectomy in Patients
Condition: Uterine Cervical Neoplasms
MeSH terms: Uterine Cervical Neoplasms
Study type: Interventional
Phase: Phase 2

Summary: 
      The objective of the study is to evaluate the impact and the outcome of bladder training
      during post-operative hospital stay after radical hysterectomy, mainly after neoadjuvant
      concurrent chemo-radiation therapy for locally advanced cervical cancer.
    


Intervention name(s): bladder training; No bladder training
Intervention type(s): Device; Procedure
Intervention description(s): vescical catheter
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: bladder training, radical hysterectomy,gynaecologic cancer
Effect of Kettlebell Training on Musculoskeletal and Cardiovascular Health
Condition: Musculoskeletal Disorders
MeSH terms: Musculoskeletal Diseases
Study type: Interventional

Summary: 
      Neck/shoulder and back pain is quite common among employees in sedentary occupations.
      Furthermore, many have a low level of fitness. Strength training with dumbbells has been
      shown to alleviate neck/shoulder pain, but many people prefer to also have alternative
      training options. Empirically, kettlebell training works the neck/shoulder/back while at the
      same time training the cardiovascular system. This type of training has not previously been
      tested in a randomized controlled trial. The aim of this study is to test the effect of
      kettlebell training on musculoskeletal pain, fitness, and muscle strength.
    


Intervention name(s): Ketllebell training; Control
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Kettlebell training 3 x 20 min a week for 8 weeks; Receives a health examination before and after the intervention period, and are advised to stay active.
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Study to Evaluate the Effects of a High-Fat Meal on Bexagliflozin in Healthy Subjects
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study was to investigate the effect of a high-fat meal on the levels of
      bexagliflozin in the blood in healthy subjects.
    

Detailed description: 
      This was a single center, Phase 1, open-label, 2 × 2 crossover study designed to assess the
      effects of a high-fat meal on the PK of orally administered bexagliflozin tablets in 18
      healthy adults. Subjects were randomized 1:1 to receive bexagliflozin tablets with a high-fat
      meal on day 1 and without a meal on day 8 after an overnight fast or to receive bexagliflozin
      tablets without a meal on day 1 after an overnight fast and with a high-fat meal on day 8.

      Subjects were admitted to the clinic on the day before dosing in each treatment period, and
      stayed in the clinic until 48 h post-dose.

      The subjects dosed in the fed state received an oral bexagliflozin tablet, 20 mg, 30 min
      after starting to consume a high-fat meal following an overnight fast. The meal was to be
      ingested in its entirety over an approximate 25-minute period, such that it was completed at
      least 5 minutes prior to the scheduled time of bexagliflozin dosing for the fed state
      treatment. Subjects dosed in the fasting state received an oral bexagliflozin tablet, 20 mg,
      after an overnight fast.

      Blood samples for bexagliflozin plasma concentrations were collected at 0 h (pre-dose), and
      at 1, 2, 3, 4, 5, 6, 8, 10, 12, 16, 24, 36, and 48 h post-dose. Urine collection in 12 h
      batches was performed at pre-dose (-12 to 0 h on day 0 and day 7), and at post-dose (0 to 12
      h, 12 to 24 h, 24 to 36 h, and 36 to 48 h) intervals.
    

Intervention name(s): Bexagliflozin
Intervention type(s): Drug
Intervention description(s): Bexagliflozin tablet, 20 mg
Other intervention name(s): EGT0001442, EGT0001474
Intervention MeSH terms: Bexagliflozin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment