A Clinical Study of Pain and Discomfort Associated With Advanced Lung Cancer
Condition: Advanced Lung Cancer
MeSH terms: Lung Neoplasms
Study type: Interventional

Summary: 
      In this research, the patients with advanced lung cancer accompanied by pain and discomfort
      were treated by injecting freshly manufactured tissue permeable hyaluronan fragment HA35 into
      the tissue under abdominal adipose.
    

Detailed description: 
      Pain is generally considered the most common symptom of lung cancer. The three most common
      causes of pain in patients with advanced lung cancer are: 1. metastasis of lung cancer to the
      bones, which accounts for approximately 34 percent of lung cancer pain; 2. Presence of a
      Pancoast tumor, located at the top of the lung close to the brachial plexus nerves and
      cervical sympathetic nerves, which accounts for approximately 31 percent of lung cancer pain;
      3. Spread of the cancer into the chest wall, accounting for approximately 21 percent of lung
      cancer pain.

      Palliative care is a specialized field that aims to alleviate symptoms and maximize the
      patient's quality of life. Palliative care does not focus on curing the disease or prolonging
      life, which is the goal of other cancer treatments, such as chemotherapy. However, palliative
      care is an important part of the patient's treatment plan and encompasses physical symptoms,
      psychosocial distress, spiritual distress, and caregiver distress.

      The management of pain due to lung cancer may include a combination of medications, such as
      non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, opioids (pain medications),
      and antidepressants. For metastases to the bone, radiation therapy and the use of
      bisphosphonates (drugs to help prevent bone breakdown) can alleviate pain. In addition,
      smoking cessation (stopping smoking) is recommended, as surveys have revealed that lung
      cancer patients who continue to smoke after diagnosis have a higher incidence of pain and
      other lung cancer complications than nonsmokers and those who quit smoking.

      While pain is the most common symptom of lung cancer, other symptoms include: persistent
      coughing，wheezing，shortness of breath，hoarseness，weight loss，loss of appetite，fatigue or
      feeling weak and respiratory infections (like bronchitis or pneumonia) that don't go away or
      keep returning.

      Hyaluronidase PH20 produced 35 kDa tissue permeable low molecular weight hyaluronan fragment
      by cutting high molecular hyaluronan. The previous clinical studies had shown that local
      injection of 35 kDa hyaluronan fragment effectively relieved inflammatory pain and
      neuropathic pain and promoted chronic wound healing.
    

Intervention name(s): 35 kDa hyaluronan fragment
Intervention type(s): Drug
Intervention description(s): 100 mg of 35kDa hyaluronan fragment was injected deeply into abdominal fat layer once a day for 28 consecutive days.
Other intervention name(s): B-HA
Intervention MeSH terms: Hyaluronic Acid
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: 35kDa hyaluronan fragment; palliative care; pain and discomfort; cough; fatigue