bioihbjkbjnl/mcl2 huggingface dataset:
The Influences Of Anterior Capsule Polishing On Anterior Capsular Changes and Intraocular Lenses Stability of Super High Myopic Eyes
Condition: Myopia, High, With Cataract and Anterior Capsule Polished
MeSH terms: Cataract; Myopia
Study type: Interventional

Summary: 
      A prospective study included 20 patients with super high myopia who underwent bilateral
      uneventful cataract. 360°anterior capsule polishing was performed with double-ended capsule
      polisher randomly in one eye, and the opposite unpolished was used as the control. The
      refractive state and size of anterior opening were measured at postoperative 1 day as the
      baseline. Then they followed up at 1 month, 3 months and 6 months after surgery to record
      refractive state, higher-order aberrations, size of anterior opening, tilt and decentration
      of IOL (intraocular lenses)and PAD(postoperative aqueous depth). The paired t test was used
      to compare the differences between the two groups, and the same test the postoperative
      follow-up comparing with the baseline.
    


Intervention name(s): 360°anterior capsule polishing
Intervention type(s): Procedure
Intervention description(s): 360°anterior capsule polishing was performed with double-ended capsule polisher
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Obesity: an Underappreciate Risk Factor for Severe Form of COVID-19
Condition: COVID-19 Pandemic; Obesity
MeSH terms: COVID-19; Obesity
Study type: Observational [Patient Registry]

Summary: 
      Our study has the objective of identifying the epidemiological profil of the patients, as
      well as, the clinical, radiological and prognosis of obese patients with covid 19.
    

Detailed description: 
      Introduction: COVID 19 pandemic continues to progress with a considerable mortality and
      morbidity throughout the world since its emergence in December 2019. Many studies were
      conducted to identify the predictive factors of mortality of those infected with the virus.
      The previous studies noticed that obesity seems to be associated with severe form of
      respiratory distress syndrome. Our study has the objective of identifying the epidemiological
      profil of the patients, as well as, the clinical, radiological and prognosis of obese
      patients with covid 19.

      Methods: investigators led a retrospective monocentric, descriptive and analytic study, in
      the department of anesthesia and intensive care unit of the university hospital of Mohamed VI
      Oujda, in Morocco, from March 2020 to October 2021, including all the patients tested
      positive for the infection.
    

Intervention name(s): Obesity
Intervention type(s): Device
Intervention description(s): the objective of identifying the epidemiological profil of the patients, as well as, the clinical, radiological and prognosis of obese patients with covid 19
Observational model: Cohort
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        investigators have included all the patients presenting an infection with SARS-CoV-2 (1069
        patients) diagnosed following the regarding of the world health organization (WHO),
        confirmed by a PCR of a nasopharyngeal swap, or highly suspected images on thoracic CT
        scans, that were hospitalized in the intensive care unit.
Field of Effects of Two Commercial Preparations of Botulinum Toxin Type A
Condition: Wrinkles in Frontal Area
Study type: Interventional
Phase: Phase 4

Summary: 
      The objective of this study is to compare the field of effects of the botulinum toxins
      (Dysport® and Botox®) using two equivalence-ratios and to gather supportive information, such
      as more detailed data on the effectiveness in reduction of wrinkles and duration of action on
      the upper part of the face of both products, trough scales and photographs evaluations.
    

Detailed description: 
      This was a monocentric, prospective, randomized and double-blind study. Twenty nine female
      patients, presenting with moderate to severe forehead wrinkles, with sweating ability who had
      never undergone previous BoNT-A injections were enrolled. Subjects have received botulinum
      toxin type-A injections in two forehead sites, Botox 2U and Dysport 5U, both reconstituted in
      the same volume of 0.02 mL per point. Baseline, twenty-eight and 112 days later, clinical and
      photographic assessments, Minor´s test, and electromyographic (EMG) evaluations were
      performed.
    

Intervention name(s): Botulinum Toxin Type A (Dysport®); Botulinum Toxin Type A/Botox®; Botulinum Toxin Type A/Dysport®
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Botulinum toxin A (Dysport®)will be administered according to an equivalence ratio of 2,5:1. Both reconstituted in the same volume per point, injected in the forehead determined site.
-Dysport®: 5 units will be injected in the left or right forehead side.; 2 units will be injected in the left or right forehead side.(opposite side of dysport injection); Botulinum toxin A (Dysport®)will be administered according to an equivalence ratio of 2:1. Both reconstituted in the same volume per point, injected in the forehead determined site.
-Dysport®: 4 units will be injected in the left or right forehead side, 2:1 ratio Dysport/Botox.
Intervention MeSH terms: Botulinum Toxins; Botulinum Toxins, Type A; abobotulinumtoxinA
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Botulinum toxin type A; field effects; dose-equivalence; anhydrotic action halos
Nutritional Intervention For The Treatment Of Uncomplicated SAM
Condition: Child Nutrition Disorders
MeSH terms: Nutrition Disorders; Child Nutrition Disorders
Study type: Interventional

Summary: 
      nutritional intervention with ready to use therapeutic food (plumpy nut. by Unicef) and
      Prebiotics supplimentation ( Galactooligosaccarides). will be given to uncomplicated severe
      acute malnourished children of 06 months to 59 months of age in southern Punjab Pakistan.one
      group will be given Ready to use therapeutic food and placebo the other group will be given
      Prebiotics supplementation (Galacto oligosaccharides) with RUTF ( Ready to use therapeutic
      Foods).for 60 days primary out will be Mid Upper Arm Circumference >11.5 centimetre
    

Detailed description: 
      it will be a double blind Randomised Controlled trial in Out Therapeutic Program centres of
      Teaching Hospital of Dera Ghazi Khan Pakistan children age of 06 months to 59 months of age
      from the community will be screened out at health centres . Uncomplicated SAM children will
      be enrolled for study Before intervention there blood sample and stool sample will be sent to
      the labs for complete blood examination and complete stool examination.

      controlled groups will be given Ready To use Therapeutic Food and Placebo (starch) 4 grams
      per day for 60 days Intervention group will be given Ready to use Therapeutic Food and
      Prebiotic ( Galactoligosaccharides 4 gram per day for 60 days
    

Intervention name(s): Nutritional intervention with Ready to use theraputic food (RUTF) and prebiotic GOS (galacto oligosaccharides) in combination; Ready to use theraputic food (RUTF) and Starch (placebo)
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 4gm of prebiotic GOS ( Galactooligosaccharides) and Ready to use theraputic food (RUTF) as per WHO standard on daily basis for 60 Days; Ready to use therapeutic food (RUTF) as per WHO standard and (Starch Placebo) soluble in water and mix in food on daily basis for 60 Days
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Investigating the Immune Response to 4CMenB in Infants
Condition: Meningitis
MeSH terms: Meningitis
Study type: Interventional
Phase: Phase 4

Summary: 
      This randomised, open-label, single-centre, descriptive study aims to investigate gene
      expression (i.e what genes are 'switched on' and 'off') following vaccination with 4CMenB and
      to relate this to vaccine reactions and to immune response.

      160 healthy Caucasian infants aged 8-12 weeks (at time of first visit) who have not yet
      received their routine infant immunisations will be recruited. Participation in the study
      will be limited to to Caucasian infants (defined as having two Caucasian parents). This is so
      that baseline variability in gene expression data which is to some degree affected by
      ethnicity is reduced.

      Participants will be randomised to either a 'test' group or 'control' group depending on what
      4CMenB schedule they receive, with 80 infants in each.

      All participants will receive the usual paediatric immunisations according to the UK national
      immunisation schedule. In addition, participants in the test groups will receive 4CMenB at 2,
      4 and at 12 months while those in the control groups will receive the same vaccine at 5, 7
      and 13 months. Blood samples will be taken from each infant at specified time points before
      and after vaccination to address the objectives of the study.

      In addition, oro-pharyneal swabs will be obtained around different vaccination timepoints to
      investigate the effect of 4CMenB vaccination on the oro-pharyngeal Neisseria microbiome.
    

Detailed description: 
      The incidence of meningococcal disease is 0.2-14 per 100,000 in industrialized countries. In
      England and Wales, during the period 2005-2010, there were 900-1300 cases annually. Disease
      is commonest in infants, young children and adolescents and case fatality is high at 8-10%.

      Until recently there were no licensed vaccines against serogroup B meningococcal disease,
      although vaccines against epidemic strains of MenB have been used in several countries.

      Unfortunately, 4CMenB is associated with significant reactogenicity. This is presumably
      related to the presence of various bacterial surface components present in the outer membrane
      vessicles (OMVs), including lipopolysacchride (LPS), which are capable of activating the
      innate immune response. The host pathways responsible for reactogenicity to OMV vaccines, and
      indeed to other vaccines, are not yet established, and the relationship between
      reactogenicity and immunogenicity is not clear.

      This study will provide information about pathways and mechanisms of immunity and may
      identify gene expression signals which can be used in future vaccine design and evaluation.
    

Intervention name(s): 4CMenB
Intervention type(s): Biological
Intervention description(s): 0.5ml IM
Other intervention name(s): Bexsero
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Teaching First Aid and Trauma Management to School Students
Condition: Trauma-related Wound; Head Injury; Choking; Nose Bleed; Child, Only; Emergencies
MeSH terms: Epistaxis; Craniocerebral Trauma; Emergencies; Wounds and Injuries
Study type: Interventional

Summary: 
      This proposal aims to describe research that will utilize first aid in primary education
      students and will attempt to identify the frequency with which the training should be
      repeated and the type of trainer who will carry out the training program.
    

Detailed description: 
      The training concerns courses with theoretical knowledge and practical skills related to
      first aid. Taking into account children's cognitive and psychological development, students
      will be trained in the following topics: calling an ambulance, managing bleeding, handling an
      unconscious patient, drowning, and managing a head injury. Classroom teachers and specialized
      staff will teach classes. The evaluation of knowledge and skills will be done with a
      questionnaire. The evaluation will take place before and immediately after the training, two
      months and seven months after the training.
    

Intervention name(s): First aid lessons
Intervention type(s): Other
Intervention description(s): The school children will have first aid training
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: first aid training, children
The Effect of AI-based Microbiome Diet on IBS-M Symptoms
Condition: Irritable Bowel Syndrome Mixed
MeSH terms: Irritable Bowel Syndrome
Study type: Interventional

Summary: 
      This study was designed as a pilot, open-labelled study. We enrolled consecutive IBS-M
      patients (n=25, 19 females, 46.06 ± 13.11 years) according to Rome IV criteria. Fecal samples
      were obtained from all patients twice (pre- and post-intervention) and high-throughput 16S
      rRNA sequencing was performed. Patients were divided into two groups based on age, gender and
      microbiome matched.

      Six weeks of AI-based microbiome diet (n=14) for group 1 and standard IBS diet (Control
      group, n=11) for group 2 were followed. AI-based diet was designed based on optimizing a
      personalized nutritional strategy by an algorithm regarding individual gut microbiome
      features. An algorithm assessing an IBS index score using microbiome composition attempted to
      design the optimized diets based on modulating microbiome towards the healthy scores.
      Baseline and post-intervention IBS-SSS (symptom severity scale) scores and fecal microbiome
      analyses were compared.
    


Intervention name(s): Personalized microbiome diet
Intervention type(s): Dietary Supplement
Intervention description(s): The personalized nutrition model estimates the optimal micronutrient compositions for a required microbiome modulation. In this study, we computed the microbiome modulation needed for an IBS case, based on the IBS-indices generated by the machine learning models. According to that, the baseline microbiome compositions are perturbed randomly with a small probability p. Perturbed profiles are accepted with a probability proportional to the decrease in the IBS-index as suggested by Metropolis sampling. This Monte-Carlo random walk in the microbiome composition space is expected to meet a low IBS-index microbiome composition nearby the baseline microbiome composition of the patient with a minimal modulation. The personalized nutrition model, then, estimates the optimized nutritional composition needed for this individual, expecting to drive the IBS-index to lower values.
Other intervention name(s): ARTIFICIAL INTELLIGENCE BASED PERSONALIZED DIET
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Consumption of Whole Grains and Legumes Modulates the Genetic Effect of the APOA5 -1131C Variant
Condition: Subjects With Mild Hypertriglyceridemia in Type 2 DM
MeSH terms: Hypertriglyceridemia
Study type: Interventional

Summary: 
      We examined whether a substitution of whole grains and legumes for refined rice in a high
      carbohydrate diet (about 65% of energy derived from carbohydrate) may modify the effect of
      this variant on changes in apolipoprotein A-V (apoA-V) and triglyceride concentrations.
    

Detailed description: 
      We genotyped the APOA5 -1131T>C in individuals with impaired fasting glucose (IFG) or newly
      diagnosed type 2 diabetes, who were randomly assigned to either a group ingesting whole grain
      and legume meals daily or a control group for 12 weeks.
    

Intervention name(s): Dietary intervention
Intervention type(s): Dietary Supplement
Intervention description(s): The intervention program consisted of replacing of refined rice intake with 1/3 of legumes, 1/3 of barleys, and 1/3 of whole grains three times per day as a high carbohydrate source and increased vegetable intake to at least 6 units (30-70 g/unit) per day for sufficient dietary fiber intake. The subjects were recommended to drink no more than one alcoholic beverage drink (15 g alcohol) per day and were assigned physical activity consisting of a regular 30-min walk after dinner each day. Participants were also instructed to record their physical activity diary for 24 h every 4 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Validation of 3 Dimensional Laparoscopic System in Disral Pancreatectomy and Splenectomy
Condition: Benign Neoplasm of Body of Pancreas; Benign Neoplasm of Tail of Pancreas
MeSH terms: Neoplasms; Brain Neoplasms
Study type: Interventional
Phase: Phase 4

Summary: 
      Traditionally, laparoscopy has been based on 2-dimensional (2D) imaging, which has
      represented a considerable challenge for those approaching this technique. Thus,
      3-dimensional (3D) visualization technology for laparoscopy has been proposed, since the
      early 1990s, as a way to facilitate laparoscopic performance. However, early 3D laparoscopic
      technology was limited in terms of image quality, so that its use had not been implemented.
      More recently, industry has developed novel 3D systems where the imaging is similar to
      stereoscopic vision, in which the depth perception is achieved by different unique images
      received by each eye. Thus, more recent studies have suggested a possible advantage provided
      by these new 3D systems during laparoscopic performance. However, comparative assessments of
      new generation 3D vs 2D laparoscopy remain limited, especially in the hepatobiliary and
      pancreatic field.

      To assess the benefits and harms of use of three dimensional systems versus two dimensional
      systems during laparoscopic distal pancreatectomy.
    

Detailed description: 
      Procedures

        1. the investigators will take the patient consent for this clinical trial.

        2. The participants will be divided with two groups with block randomized method

        3. Skillful pancreatic surgeon will perform 2D or 3D laparoscopic distal pancreatectomy.

        4. The participants will be monitor the intraoperative and postoperative course.

      Data collection

        1. operation video : operation time, number of errors (missed grasp, loss of material)

             1. Segmental operation time according to procedure

             2. Numbers of errors during operation

        2. clinical parameters:

             1. Blood examination : complete blood count (hemoglobin, white blood cell count),
                amylase, lipase, etc.

             2. Radiological examination: X-ray, Computed Tomography (CT), Magnetic Resonance
                Imaging (MRI), etc

             3. Medical records : hospital stay after operation, the time to eating, pathologic
                examination

        3. Subjective scoring in the view of operator, 1st assist.

             1. Scoring for imaging quality

             2. Scoring for harms of 3D/2D laparoscopic system

             3. Scoring for overall demand
    

Intervention name(s): 3-dimensional distal pancreatectomy; 2-dimensional distal pancreatectomy
Intervention type(s): Device; Device
Intervention description(s): 3D laparoscopy; 2D laparoscopy
Other intervention name(s): 3D; 2D
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Serum Progesterone on the Day of Embryo Transfer and Pregnancy Rate.
Condition: Ongoing Pregnancy Rate
Study type: Observational

Summary: 
      This study aims to analyze whether serum Progsterone levels on the day of Embryo Transfer are
      related with Ongoing Pregnancy rate in artificial endometrial preparation cycles with
      intravaginal micronized progesterone.
    


Intervention name(s): Analysis of serum Progesterone in blood sample
Intervention type(s): Diagnostic Test
Intervention description(s): Levels of progesterone will be determined on the day of embryo transfer in patients undergoing artificial endometrial preparation cycles.
Intervention MeSH terms: Progesterone
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Women who are undergoing IVF treatments with artificial endometrial preparation with
        hormonal replacement therapy.
      
Biospecimen description: 
      Serum
Quality of Life and Body Image in Women Underwent Thighplasty
Condition: Obesity
Study type: Interventional
Phase: Phase 1

Summary: 
      Obesity is a chronic disease now considered a major public health concern in the global
      context, as it causes or exacerbates many diseases limitations in providing quality of life
      and higher treatment costs. The increase in the number of patients undergoing bariatric
      surgery and the excess skin and subcutaneous tissue adjacent to slimming collaborate in the
      search for growth by plastic surgery. Currently several techniques of thighplasty has been
      submitted but no studies were found that evaluated the characteristic clinical and emotional
      resulting from this procedure. This study has as a goal to evaluate the body image and
      quality of life in women submitted to thighplasty.
    

Detailed description: 
      The patients have been evaluated for two different questionnaires, the Body Dysmorphic
      Disorder Examination (BDDE) and Impact Weight on Quality of Life - Lite (IWQoL-Lite). The
      sample consists of 50 patients with the desire to undergo to the thighplasty. However 25 are
      from study group and 25 control group. Just the study group was undergoing plastic surgery.
      The questionnaires have applied by signing the consent form, after 3 and 6 months both
      groups. This study is a clinical trial, control, primary, longitudinal, no random,
      analytical, held in a single center.
    

Intervention name(s): thighplasty
Intervention type(s): Procedure
Intervention description(s): Plastic surgery of thigh
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: bariatric surgery; plastic surgery; thigh; obesity; body image; quality of life
Milk Matters in Malnutrition, is it the Lactose or Dairy Protein?
Condition: Malnutrition, Child
MeSH terms: Malnutrition; Child Nutrition Disorders
Study type: Interventional

Summary: 
      This study is to look at the types of sugar and protein composition in the treatment of
      moderate acute malnutrition and its effects on gut health. The study will use 4 different
      types of ready to use supplementary foods to see which one if any has better recovery rate
      along with looking into the gut health. Children will be treated using one food for up to 12
      weeks. A subset of about 400 will be tested for intestinal permeability using the dual sugar
      test.
    


Intervention name(s): RUSF skimmed milk powder; RUSF milk protein concentrate and sucrose; RUSF soy protein and whey permeate; RUSF soy and sucrose
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): ready-to-use supplementary foods 75 kcal/kg/day (314 kJ/kg/day) and full daily doses of vitamins and micronutrients; ready-to-use supplementary foods 75 kcal/kg/day (314 kJ/kg/day) and full daily doses of vitamins and micronutrients; ready-to-use supplementary foods 75 kcal/kg/day (314 kJ/kg/day) and full daily doses of vitamins and micronutrients; ready-to-use supplementary foods 75 kcal/kg/day (314 kJ/kg/day) and full daily doses of vitamins and micronutrients
Intervention MeSH terms: Caseins
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment