bioihbjkbjnl/mcl2 huggingface dataset:
Effect of Chinese Traditional Medicine for Post Revascularization Treatment of Coronary Artery Disease
Condition: Percutaneous Coronary Artery Intervention; Coronary Artery Bypass Graft; Acute Coronary Syndrome
MeSH terms: Coronary Artery Disease; Myocardial Ischemia; Coronary Disease; Acute Coronary Syndrome
Study type: Interventional

Summary: 
      The purpose of this study is to built the standard of Chinese Traditional Medicine test for
      Post percutaneous coronary artery intervention and coronary artery bypass graft，also for
      acute coronary syndrome，according to the multi-site、random large sample test.
    


Intervention name(s): cipher prescription 1; cipher prescription 2
Intervention type(s): Drug; Drug
Intervention description(s): Drug granules include ginseng,RADIX NOTOGINSENG,prepared RHIZOMA PINELLIAE with alumen radix glyrrhigae calcaren once daily for 180 days; Placebo include amidon、bitter principles and diluents bases once daily for 180 days
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: percutaneous coronary artery intervention; coronary artery bypass graft; acute coronary syndrome
Validation Study on RENEW's Aingeal at KK Women's and Children's Hospital
Condition: Vital Sign; Heart Rate; Respiratory Rate
Study type: Interventional

Summary: 
      This proposal describes the evaluation of a CE-marked, FDA cleared vital signs Surveillance
      Monitoring system in a paediatric outpatient population in KK Women's and Children's Hospital
      ("KKH"), the main tertiary women and children hospital in Singapore. User acceptance of
      Aingeal and the Surveillance System will be considered within the clinical settings.
    

Detailed description: 
      RENEW's Surveillance Monitoring system is made up of two main components:

      a patient-worn wireless vital signs monitor (Aingeal) that transmits data over Wi-Fi to a
      central station software platform (Surveillance Station). The Aingeal device measures single
      lead ECG, heart rate, respiration waveform and rate, and skin temperature. A snapshot of data
      is transmitted by the devices intermittently to the Surveillance Station, enabling vital
      signs trends to be plotted. This proposal describes the evaluation of RENEW's Aingeal device
      in a paediatric outpatient population in KK Women's and Children's Hospital ("KKH"), the main
      tertiary women and children hospital in Singapore. In the paediatric population, assessment
      of RENEW's Aingeal device will include the accuracy of the device at deriving heart rate from
      single lead ECG and at deriving respiratory rate when compared against a commonly used vital
      signs monitor. User acceptance of Aingeal and the Surveillance System will be considered
      within the clinical settings.
    

Intervention name(s): Heart rate monitoring; Respiratory rate monitoring
Intervention type(s): Other; Other
Intervention description(s): The heart rate of recruited patients will be monitored for 15 minutes over 2 phases:
i) 10 minutes at rest ii) 5 minutes during physical activity in the form of walking or playing; The heart rate of recruited patients will be monitored for 15 minutes over 2 phases:
i) 10 minutes at rest ii) 5 minutes during physical activity in the form of walking or playing
Intervention model: Single Group Assignment
Intervention model description: All patients recruited will be wearing the Aingeal device at a paediatric outpatient clinic setting.
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Vital sign monitoring; Heart rate; Respiratory rate
Substudy of the Accuracy of Ingestible Event Marker (IEM) Detection by the Medical Information Device #1 (MIND1)
Condition: Device Latency
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study was to determine the accuracy of IEM detection by the MIND1 System
      by completing a series of Patch applications and IEM ingestions in the clinic.
    

Detailed description: 
      The OSMITTER study protocol was designed as a master protocol governing multiple substudies
      for the rapid assessment of candidate subcomponents for the MIND1 System. This substudy was
      conducted to determine the accuracy of IEM detection by the MIND1 System by completing a
      series of Patch applications and IEM ingestions in the clinic.
    

Intervention name(s): Placebo; Combination product of Aripiprazole + IEM + Sensor + MIND1 Application
Intervention type(s): Drug; Combination Product
Intervention description(s): Oral placebo-embedded IEM tablet.; Combination product of aripiprazole tablet embedded with sensor and wearable patch with MIND1 system on smartphone
Other intervention name(s): Abilify MyCite®
Intervention MeSH terms: Aripiprazole
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: OPC-14597 Digital; Aripiprazole; Medical Information Device #1 System (MIND1); Ingestible Event Marker
Intraocular Pressure Changes Associated With Tracheal Extubation: Comparison of Sugammadex With Conventional Reversal of Neuromuscular Blockade
Condition: Intraocular Pressure Changes During Tracheal Extubation
Study type: Interventional
Phase: Phase 4

Summary: 
      The aim of this study, comparison of effects of sugammadex versus neostigmine/atropine
      combination on hemodynamic parameters and intraocular pressure during tracheal extubation.

      This prospective, randomised study was designed to compare two reversal methods with respect
      to changes in IOP, heart rate and blood pressure during tracheal extubation period.
    


Intervention name(s): sugammadex; neostigmine+atropine
Intervention type(s): Drug; Drug
Intervention description(s): sugammadex 2 mg/kg; neostigmine 0,05 mg/kg + atropine 0,025 mg/kg
Intervention MeSH terms: Atropine; Neostigmine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Diagnostic
Keywords: two reversal methods; changes in IOP; heart rate; blood pressure; tracheal extubation
Drug-drug Interaction Study of SPH3127
Condition: Drug Drug Interaction
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      A single center, open-label, fixed sequence Phase 1, drug-drug interaction (DDI) study in
      male healthy subjects.
    


Intervention name(s): SPH3127 tablet; Itraconazole; SPH3127 tablet; Rifampin
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): 100mg once daily on Day 1 and Day 8; 200mg once daily from Day 3 to Day10.; 200mg once daily on Day 1 and Day 12.; 600mg once daily from Day 3 to Day13.
Intervention MeSH terms: Itraconazole; Rifampin
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Mechanisms of Anxiety and Depression Study
Condition: Depression; Anxiety
MeSH terms: Depression; Depressive Disorder; Anxiety Disorders
Study type: Observational

Summary: 
      Eligible participants will come in for three separate visits in which they will be
      interviewed, perform a variety of tasks, and undergo a non-invasive MRI scan. The
      investigators anticipate that (1) participants with anxiety and depression will likely
      perform differently than the healthy controls on cognitive tasks, (2) participants with
      anxiety and depression will likely show differences in brain functionality compared to the
      healthy controls, and (3) depression and anxiety likely share some underlying mechanisms.
    

Detailed description: 
      In order to determine eligibility, a brief phone screen lasting approximately 15 minutes will
      be conducted. If participants are eligible, they will be asked to come in for three separate
      visits. During the first visit, participants will complete questionnaires as well as a
      structured interview with one of the study's staff members at Palo Alto University in Los
      Altos. During the second visit, participants would come to Palo Alto University in Los Altos
      and complete questionnaires as well as a testing session involving various tasks. During the
      third visit, participants would undergo a non-invasive brain scan in which participants would
      complete a task as well as various questionnaires at Stanford University in Stanford.

      The investigators have flexible hours and can work around participants' schedules! To inquire
      more about participation, participants can either email the investigators at
      paloalto.study@gmail.com or call the investigators at (650) 417-2000 ext. 3642
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        The investigators expect to enroll 50 right-handed, English as first language, adults will
        be recruited from the community through various advertisements. The investigators expect
        that 25 will be healthy controls and 25 will be a clinical sample exhibiting clinically
        significant symptoms of anxiety and depression.
Hyperpronation and Foot Pain
Condition: Arthritis of Knee
MeSH terms: Arthritis
Study type: Interventional

Summary: 
      Effects of training and pellots
    


Intervention name(s): training and pellots
Intervention type(s): Procedure
Intervention description(s): training and pellots
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
To Evaluate the Pharmacokinetic Interactions and Safety Between Fimasartan and Rosuvastatin
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional
Phase: Phase 1

Summary: 
      A phase Ⅰ study to evaluate the pharmacokinetic interactions and safety between fimasartan
      and rosuvastatin in healthy male volunteers.
    

Detailed description: 
      After subjects have signed informed consent voluntarily, they go through screening period for
      within 21 days.

      As period I, subjects of Part A take fimasartan for 7 days and subjects of Part B take
      rosuvastatin for 7 days.

      And then, after wash out for 7 days, as period II, subjects of both Part A and B take
      fimasartan and rosuvastatin for 7 days.

      At each period, subjects of Part A have blood sampling 2nd, 4th, 6th day before medication,
      7th day before and 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 24, 36, and 48hour after
      medication(17 times in each period, 34 times in total).

      At each period, subjects of Part B have blood sampling 2nd, 4th, 6th day before medication,
      7th day before and 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 8, 12, 24, 48 and 72hour after medication(17
      times in each period, 34 times in total).
    

Intervention name(s): Fimasartan; Rosuvastatin
Intervention type(s): Drug; Drug
Intervention MeSH terms: Rosuvastatin Calcium
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: Fimasartan
Prevention of Diverticulitis by Taking a Daily Probiotic
Condition: Acute Diverticulitis
MeSH terms: Diverticulitis
Study type: Interventional

Summary: 
      There is evidence to show that daily probiotic Lactobacillus casei Shirota (LcS) in the form
      of Yakult fermented milk supports a healthy balanced population of "friendly" gut bacteria.
      This, coupled with evidence from four European trials showing probiotic benefit for recurrent
      diverticulitis and an understanding of how the disease develops, indicates that LcS may also
      be beneficial. The investigators plan to undertake a pilot study investigating whether
      consumption of once daily probiotic LcS as Yakult fermented milk would help either prevent
      attacks of diverticulitis completely or significantly reduce frequency of attacks. Subjects
      will be recruited from Surrey primary care units and will be closely monitored for 12 months
      whilst being supplied with a daily dose of for the full 12 months to see if this improves gut
      health.
    

Detailed description: 
      Because dietary fibre, obesity and diabetes are all confounding factors that influence the
      frequency and severity of attacks of diverticulitis, the research project will take account
      of this by:

        1. Monitoring dietary fibre using a diet diary

        2. Measurement of height and weight to determine BMI

        3. Screening for undiagnosed diabetes and pre-diabetes

      As well as keeping a diet diary, subjects will be asked to keep a general health diary, and
      to complete gut health questionnaires at start, 6 months and 12 months.
    

Intervention name(s): Yakult
Intervention type(s): Dietary Supplement
Intervention description(s): 62 ml dose daily for 365 days. There must be a cold chain from supplier (Yakult UK) via the primary care centre to the trial participants.
Other intervention name(s): lactobacillus casei Shirota
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: probiotic; lactobacillus; colonic diseases; dietary fibre
The SUUBI Program: Asset-Ownership for Orphaned Children in Uganda
Condition: Poverty
Study type: Interventional
Phase: Phase 1

Summary: 
      This study examines an economic empowerment model of care and support for orphaned
      adolescents in rural Uganda. The Suubi intervention focuses on economic empowerment of
      families caring for orphaned youths. It attempts to address the health risks and poor
      educational achievements resulting from poverty and limited options.
    

Detailed description: 
      The AIDS epidemic and a 20-year civil war have had a devastating impact on Uganda. The events
      have led to population displacement, worsening living conditions, exacerbation of poverty,
      and disruption of already weakened social service systems. As implemented, the Suubi Project
      goes considerably beyond the usual care, which primarily consists of institutionalization and
      reactive strategies (involving food and material aid). Specifically, the intervention
      promotes children's savings accounts, also known as children development accounts, for
      postprimary education and microenterprise development (i.e., development of small
      income-generating businesses).

      The Suubi intervention is grounded in asset theory (Sherraden 1990, 1991), which holds that
      assets (e.g., savings, educational opportunities, and economic opportunities in the form of
      income-generating activities or microenterprises) have important economic, social, and
      psychological benefits for individuals and families. Asset building is increasingly viewed as
      a critical factor for reducing poverty, improving psychosocial functioning, and positively
      affecting attitudes and behaviors.
    

Intervention name(s): Children's development account
Intervention type(s): Behavioral
Intervention description(s): Children in the experimental condition (the SUUBI program) received, in addition to the usual care, an economic empowerment intervention aimed at promoting asset accumulation for families-and consisting of three major components: 1) workshops focused on asset-building and future planning; 2) a monthly mentorship program for adolescents with peer mentors on life options; and 3) a Child Development Account (CDA), dedicated to paying for secondary schooling, vocational training and/or a family small business. The CDAs were matched savings accounts, with a match rate of 2:1 as an incentive for participants to save, but with a limit on the maximum savings that could be matched (the match cap, in this case, was equivalent to $10 a month).
Other intervention name(s): Children's savings account
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: economic empowerment model, orphans, sub-Saharan Africa
Effect of Water Intake on the DNA Adducts Formation
Condition: Healthy Adults
Study type: Interventional

Summary: 
      The main purpose of the study is to assess the effect of water intake on the formation of
      4-ABP DNA adducts.
    


Intervention name(s): 1-Increased water intake regimen; 2-Non-modified water intake regimen
Intervention type(s): Other; Other
Intervention description(s): Arm 1-Intervention; Arm 2-Control
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: healthy adults; urinary adducts; water intake
Flushes and Sertraline Trial
Condition: Menopause-Hot Flashes
MeSH terms: Hot Flashes
Study type: Interventional

Summary: 
      The primary outcome of FAST (a randomized double-blinded, placebo controlled, trial of the
      effect of sertraline vs. placebo in reducing the incidence and severity of hot flushes in
      healthy women) is to determine if 6 weeks of treatment with sertraline (50mg daily for 2
      weeks, followed by 100mg per day for 4 weeks, if tolerated) results in a greater reduction in
      hot flush score (frequency * severity) compared to placebo among women with moderate to
      severe hot flashes. The secondary aim is to determine the effect of treatment with sertraline
      on quality of life, sleep, sexual function, and mood.
    

Detailed description: 
      The primary aim of FAST is to determine if 6 weeks of treatment with sertraline (50 mg daily
      for 2 weeks, followed by 100 mg per day for 4 weeks, if tolerated) results in greater
      reduction in hot flush score (frequency x severity), frequency and severity compared to
      placebo among women with moderate to severe hot flushes.

      The Secondary Aims:To determine the effect of treatment with sertraline on quality of life,
      sleep, sexual function, mood, and cognitive function. To determine if a modified, short
      version of a sexual function instrument is valid.
    

Intervention name(s): Sertraline
Intervention type(s): Drug
Intervention MeSH terms: Sertraline
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Menopausal Symptoms; Hot flashes
a Diagnostic SIJ Injection Following a Composite of 3 Diagnostic Tests and a Pain Referral Diagram
Condition: Sacroiliac Injection
Study type: Interventional

Summary: 
      The purpose of this study is to determine the predictive value of a composite of 3 simple
      clinically practical diagnostic tests (Mekhail's test, Patrick's and Thigh thrust) combined
      with a pain referral diagram in predicting response to a single diagnostic SIJ injection.
    

Detailed description: 
      The purpose of this study is to determine the predictive value of a composite of 3 simple,
      clinically practical, diagnostic tests (Mekhail, Patrick's and Thigh thrust) combined with a
      pain referral diagram in predicting response to a single diagnostic SIJ injection. The goal
      is to test these 3 tests and compare their predictive value to the 6 tests commonly reported
      in the literature in order to provide a clinician with clinically practical special tests to
      aide in the diagnosis and treatment of SIJ mediated pain. . Specifically, we seek to evaluate
      the prognostic capacity for a series of three clinical tests (Mekhail's Test, thigh thrust
      and Patrick's Test) combined with a pain referral diagram to accurately predict the response
      (change in VAS) of a single diagnostic Sacroiliac joint and extra-capsular joint injection.
    

Intervention name(s): diagnostic exercises
Intervention type(s): Other
Other intervention name(s): questionnaires; pain surveys
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Validation of the Spanish Version of the Conceptualization of Pain Questionnaire
Condition: Child Development; Pain; Adolescent Behavior
Study type: Observational

Summary: 
      The goal of this observational study is to develop a questionnaire to assess a child's
      concept of pain and to evaluate its psychometric properties in schoolchildren aged 8-17
      years. The main question[s] it aims to answer are:

        -  Validate to Spanish language the Conceptualization of Pain Questionnaire to assess a
           child's concept of pain.

        -  Conduct an analysis to evaluate its psychometric properties. Participants will respond a
           questionnaire of 15 items and asks respondents to respond if they believe the
           items/statements to be true or false, although they are allowed to respond undecided.
    

Detailed description: 
      The inclusion criteria were: to be able to read and write in Spanish language and excluded if
      they suffered from an intellectual disability that, according to the teachers, could
      interfere with their participation in the study procedures.

      The main outcome was: The Conceptualization of Pain Questionnaire - Spanish version.
    

Intervention name(s): Validation of a questionnaire
Intervention type(s): Behavioral
Intervention description(s): The Conceptualization of Pain Questionnaire (COPAQ-S) Spanish version consist of 15 items and asks respondents to respond if they believe the items/statements to be true or false, although they are allowed to respond undecided. A score of 0 is given to incorrect responses and those marked as undecided; the sum of all the correct answers gives the total score. The higher the score, the better the participant understands the concept of pain.
Observational model: Ecologic or Community
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Schoolchildren aged 8-17 years.
      
Keywords: survey; children; health knowledge; chronic pain; pain education