Evaluation of the Effects of Obesity on Orthodontic Tooth Movement
Condition: Obesity, Childhood; Orthodontic Treatment
MeSH terms: Obesity; Pediatric Obesity
Study type: Observational [Patient Registry]

Summary: 
      In this study, bone remodeling in the gingival crevicular fluid was evaluated biochemically
      during canine distalization in obese individuals and compared with normal weight individuals.
      At the same time, the speed of tooth movement was measured in obese individuals and compared
      with normal weight individuals.
    

Detailed description: 
      Among the obese and normal weight patients who applied to Aydın Adnan Menderes University
      Faculty of Dentistry Department of Orthodontics for orthodontic treatment, those who met the
      inclusion criteria were selected for the study. Patients with Angle Class II malocclusion who
      required extraction of the maxillary first premolar tooth were included in the study. Obesity
      classification, as the World Health Organization (WHO) determines the obesity values in
      children; BMI values; <5% very thin, 5%-15% underweight, 16-85% normal, 86-95% overweight,
      and ≥95% obese. Percentile values were calculated with reference to the study "Reference
      Values for Weight, Height, Head Circumference, and Body Mass Index in Turkish Children"
      conducted by Neyzi et al. (2015). In our study, individuals with normal weight and without
      any systemic disease were determined as the control group, and individuals without any
      systemic disease other than obesity were determined as the study group. Leptin, IL-6, OPG and
      RANKL levels were measured in gingival sulcus fluid samples taken from the distal gingival
      groove of obese and healthy individuals who underwent canine distalization. Roth metal
      brackets and tubes with 0.022 inch slots were used for the fixed orthodontic treatment of the
      patients. After leveling the teeth of the patients with arch wires, it was waited for 2
      months in 19x25 stainless steel arch wire and then 150 gr distalization force was applied.
      DOS samples were taken from the distal gingival groove of teeth on day 7 (T2), day 14 (T3)
      and day 21 (T4), just before distalization force was applied (T0), 24 hours after force was
      applied (T1). In order to determine the speed of tooth movement, the patient's mouth was
      scanned on the days of DOS (T0, T1, T2, T3, T4) and in addition to these days, on the 28th
      day (T5) and at the end of the 3rd month (T6), with the 3shape Trios device and using the
      OrthoAnalyzer software. The amount of movement of the canine tooth was measured in mm. Before
      collecting the gingival groove fluid sample, the area was isolated with cotton rolls, and the
      adjacent teeth and marginal gingival area were air-dried. The Periopaper was then gently
      placed in the gingival sulci below the gingival margin for 30 seconds. Paper strips were
      individually sealed in eppendorf tubes and each sample was stored at -80°C until later
      analysis. Leptin, IL-6, OPG and RANKL levels were examined with Elisa kits from the samples
      obtained. The planned period for the study was determined as 3 months in total.
    

Intervention name(s): ELISA kits
Intervention type(s): Other
Intervention description(s): Making biochemical measurements with the ELISA kit
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Men and women patients aged between 12-18 years who have continued orthodontic treatmens
      
Keywords: Obesity; Orthodontic Treatment; Tooth movement; Biomarkers