bioihbjkbjnl/mcl2 huggingface dataset:
Optic Disc, Macula, and Retinal Nerve Fiber Layer Measurements Obtained by OCT in Thyroid Associated Ophthalmopathy
Condition: Thyroid Associated Ophthalmopathy
MeSH terms: Eye Diseases; Graves Ophthalmopathy; Thyroid Diseases
Study type: Interventional

Summary: 
      The aim of the study is to compare the measurements of retinal nerve fiber layer (RNFL),
      macula and optical disc parameters obtained by optical coherence tomography (OCT), and
      intraocular pressure (IOP) between the patients with thyroid-associated ophthalmopathy (TAO)
      and healthy controls.
    

Detailed description: 
      One hundred and thirty two eyes of 66 patients with TAO and 72 eyes of 36 healthy controls
      were included in the study. Proptosis level was determined by Hertel exophthalmometer. Optic
      disc, peripapillary retinal nerve fiber layer and macula parameters were measured by OCT. All
      measurements were compared between the patients and age and sex-matched healthy controls.
    

Intervention name(s): Optical Coherence Tomography
Intervention type(s): Device
Intervention description(s): All groups were measured by optical coherence tomography.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Thyroid ophthalmopathy; optical coherence tomography
Treatment of Androgenetic Alopecia in Females, 9 Beam
Condition: Androgenetic Alopecia; Hair Loss; Female Pattern Baldness
MeSH terms: Alopecia; Alopecia Areata
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the efficacy of the HairMax LaserComb 2009 9 beam
      model in promoting hair growth in females diagnosed with androgenetic alopecia when treatment
      is applied as directed.
    

Detailed description: 
      This is a randomized double-blind, control device clinical study across 5 sites, evaluating
      changes in terminal hair count in the evaluation zone having evidence of androgenetic
      alopecia (miniaturized hair).

      The trial with 60 female subjects who have been diagnosed with androgenetic alopecia, who are
      between 25 and 60 years of age, have Fitzpatrick Skin Types I-IV, with classifications of
      Ludwig I-4, II-1, II-2, or frontal, have active hair loss within the last 12 months.

      Subjects will use the device on three non-concurring days a week as directed per device for
      26 weeks duration.

      Initial efficacy endpoint for each subject will be assess at visit 4 (week 16).

      Safety analysis will be assessed based on the reports of adverse events during study.
    

Intervention name(s): HairMax LaserComb; Control Device
Intervention type(s): Device; Device
Intervention description(s): Device application 3 times week, for 26 weeks; Device application 3 times week, for 26 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Andregenetic Alopecia; Hair Loss; Female Pattern Baldness
A Comparison of 4% Articaine Versus 0.5%Bupivacaine for Ambulatory Surgery Under Supraclavicular Block
Condition: Upper Limb Surgery; Hand Surgery
Study type: Interventional
Phase: Phase 1

Summary: 
      Effect of 2%Articaine versus 5%bupivacaine in pt undergoing short duration surgery in upper
      limb
    

Detailed description: 
      The investigator aim to compare Articaine 2% versus bupivacaine 0.5% in patient undergoing
      upper limb procedure under ultrasound guided supraclavicular block as regard onset and
      duration of sensory and motor block
    

Intervention name(s): Articaine; Bupivacaine
Intervention type(s): Drug; Drug
Intervention description(s): Supraclavicular block with 30 ml articaine 2%; Supraclavicular block with 30 ml bupivacaine 0.5%
Other intervention name(s): Artinebsa; Marcaine
Intervention MeSH terms: Bupivacaine; Carticaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Health Services Research
Keywords: Articaine; Bupivacaine; Ultrasound; Supraclavicular block
Clinical and MRI Finding of The Temporomandibular Joint Stuck Disk
Condition: TMJ Disc Disorder
Study type: Observational

Summary: 
      the study aimed to evaluate the clinical and MRI finding of TMJ with stuck disk with
      predication of the risk factors
    

Detailed description: 
      the study aimed to evaluate the clinical and MRI finding of TMJ with stuck disk with
      predication of the risk factors. Study design: this retrospective study included patients
      diagnosed as TMJ internal derangement and all the patients examined by MRI from 2008 to 2019.
      Cases with loss of continuity of articular disk or the posterior attachment of the disk were
      considered as positive cases.
    

Intervention name(s): MRI
Intervention type(s): Diagnostic Test
Intervention description(s): MRI of TMJ
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        The retrospective study included patients seeking treatment for TMD at Al-Azhar University
        Hospital and the outpatient clinic at the Faculty of Dental Medicine of Al-Azahr
        University. The sample originally included patients who provided consent to participate in
        this study and who ultimately underwent treatment for TMJD between 2008 and 2019.
Nutrition Support for Hirschsprung Disease
Condition: Nutrition Supporting; Hirschsprung Disease; Infants; Prospective Study
MeSH terms: Hirschsprung Disease
Study type: Interventional

Summary: 
      A multi-center, prospective,randomized, non-blind, controlled study was conducted to
      investigate the effects of different pre-operative nutritional support modes on perioperative
      nutritional status, surgical treatment success rate, and rehabilitation process in children
      with Hirschsprung disease.
    


Intervention name(s): supplement nutritional supporting
Intervention type(s): Dietary Supplement
Intervention description(s): Special medical formula for the purpose of formula food
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
RSPR-007 Mannitol Challenge Trial
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a double-blind, randomised, placebo-controlled, cross-over, Phase 2 trial evaluating
      two doses (a low and a high) of CRD007 for the treatment of asthmatic trial subjects with a
      positive asthma test (mannitol challenge) prior to enrolment.
    

Detailed description: 
      The present trial will include subjects with diagnosed asthma in a provocation model which
      mimics assessments of asthma control. Mannitol challenge is an indirect asthma provocation
      test, which requires the presence of inflammatory cells, particularly mast cells, in the
      airways.

      The trial involved in total 5 subject visits and will last for a maximum of 30 days for each
      subject from Visit 2 (Randomisation) to Visit 5 (Follow up).

      Visit 2,3, and 4 will be treatment visits where Investigational Medicinal Product (IMP) is
      administrated 3 hours before the Mannitol challenge.
    

Intervention name(s): CRD007; Placebo
Intervention type(s): Drug; Other
Intervention description(s): One single dose given 3 hours prior to Mannitol challenge; One single dose given 3 hours prior to Mannitol challenge
Other intervention name(s): Pemirolast sodium
Intervention MeSH terms: Pemirolast
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Cleaner Air for Better Cardiac Biomarkers
Condition: Cardiovascular Diseases
MeSH terms: Cardiovascular Diseases
Study type: Interventional

Summary: 
      This pilot project is a randomized, double-blind, sham-controlled trial investigating whether
      in-home air pollution reductions using portable air cleaners (PACs) can decrease circulating
      concentrations of biomarkers of inflammation. Using both a targeted approach to study the
      established biomarker TNFa and an exploratory approach with a commercially available
      proteomic panel, the researchers will measure concentrations of biomarkers before and after
      four weeks of home PAC use in a cohort of 74 adults with hypertension recruited from NYU
      outpatient clinical settings. Participants will also track home blood pressure measurements
      for additional exploratory analysis of potential mediation of PAC-associated decreases in
      blood pressure by biomarker concentration changes.
    

Detailed description: 
      In Aim 1, the researchers will evaluate associations with PAC use with a priori specified
      biomarker of inflammation, tumor necrosis factor alpha (TNFα). The researchers will determine
      if 4 weeks of home air filtration with PACs compared to sham is associated with significant
      reductions in TNFα concentrations when measured before and after intervention. Blood samples
      will be collected from 74 study participants before and after 4 weeks of PAC use (true and
      sham) for biomarker concentration measurement. In Aim 2, the researchers will determine if
      reductions in fine particulate matter (<2.5 μm in diameter, PM2.5) as a continuous variable
      are associated with significant reductions TNFα concentrations over a four-week period.
    

Intervention name(s): Portable air cleaner (PAC); Sham Portable air cleaner (PAC)
Intervention type(s): Other; Other
Intervention description(s): Commercially available Portable air cleaners (PAC) contain carbon filters that reduce volatile organic carbons and can reduce odors. Because of this, the researchers will remove the carbon filters from all air purifiers to preserve blinding. This will be done by unblinded research staff and devices will be labelled with an ID number to preserve blinding of the rest of the research team.; Sham Portable air cleaner (PAC) are commercially available portable air cleaners with the carbon filters and the HEPA filters removed. This will be done by unblinded research staff and devices will be labelled with an ID number to preserve blinding of the rest of the research team.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Robotic Rehabilitation Treatment of Stroke Patients
Condition: Stroke, Acute; Stroke, Ischemic
MeSH terms: Stroke; Ischemic Stroke
Study type: Interventional

Summary: 
      Storke results in severe deterioration in quality of life and exercise. Severe disorders need
      to be treated as soon as possible and they need to be rehabilitated quickly in order for
      motor functions to develop properly. In the acute / subacute phase, patients are given
      robotic treatment. In addition to the study of mtoros functions, the study of gait and
      codination is the primary result. Patients treated with soft exoskeleton receive 15
      treatments and movement testing is performed continuously. Members of the control group
      receive standard rehabilitation therapy. After 3 weeks, both groups will participate in a
      control study and then in a repeat control study at week 6. Our main goal is to compare the
      results and determine the efficiency of the robotic device.
    


Intervention name(s): Neurorehabilitation; Physiotherapy
Intervention type(s): Other; Other
Intervention description(s): Neurorehabilitation with soft exsoskeleton robotic 3-week-long; Physiotherapy 3-week-long
Other intervention name(s): Rob group; Controll groum
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: balance; soft exoskeleton; walk; robotic
Maintenance of Physical Condition and Physical Activity at One Year After Cardiac Rehabilitation Program
Condition: Coronary Disease; Acute Coronary Syndrome
MeSH terms: Acute Coronary Syndrome; Coronary Disease
Study type: Interventional

Summary: 
      Maintaining physical activity post-cardiac rehabilitation (CR) has a major role in disease
      progression and patient prognosis, especially given its potential impact on physical
      condition. Unfortunately, during a nursing interview carried out 6 months after the CR at the
      Center Hospitalier de Cholet, we find that 40% do not maintain regular physical activity.
      This observation is in line with the literature since it emerges respectively at 2 months and
      1 year post-CR that between 47% and 59% of patients do not comply with the recommendations in
      terms of physical activity (Guiraud et al, 2012).

      However, data suggest that during the post-CR follow-up phase at 6 months, there could be a
      maintenance of the physical condition assessed via the distance at the 6-minutes walk test
      (Pavy et al, 2012; Racodon et al, 2019). There is a lack of data on the maintenance of
      physical condition beyond 6 months since no study has evaluated the maintenance of physical
      condition at 1 year post-CR by 6-minutes walk test.
    

Detailed description: 
      The objective of this study is to examine the maintenance of physical condition at one year
      after cardiac rehabilitation program by the 6-minutes walk test.
    

Intervention name(s): Assigned intervention - procedure
Intervention type(s): Other
Intervention description(s): This study is defined in 3 stages :
STEP 1 : during the cardiac rehabilitation program over 4 weeks 6 minute walk test, questionnaires
STEP 2 : monitoring at 6 months after cardiac rehabilitation program Nurse interview, 6 minute walk test, questionnaires
STEP 3 : monitoring at one year after cardiac rehabilitation program Nurse interview, 6 minute walk test, questionnaires
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: physical condition; physical activity; cardiac rehabilitation
DETERMINE-preserved - Dapagliflozin Effect on Exercise Capacity Using a 6-minute Walk Test in Patients With Heart Failure With Preserved Ejection Fraction
Condition: Heart Failure With Preserved Ejection Fraction (HFpEF)
MeSH terms: Heart Failure
Study type: Interventional
Phase: Phase 3

Summary: 
      International, Multicentre, Parallel-group, Randomised, Double-blind, Placebo-controlled,
      Phase III Study Evaluating the effect of Dapagliflozin on Exercise Capacity in Heart Failure
      Patients with Preserved Ejection Fraction (HFpEF)
    


Intervention name(s): Dapagliflozin; Placebo
Intervention type(s): Drug; Other
Intervention description(s): Tablets administered orally once daily. Treatment start within 24h after randomisation for 16 weeks.; Tablets administered orally once daily. Treatment start within 24h after randomisation for 16 weeks.
Intervention MeSH terms: Dapagliflozin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Development of Eye-tracking Based Markers for Autism in Young Children
Condition: Autism Spectrum Disorder
MeSH terms: Autistic Disorder; Autism Spectrum Disorder
Study type: Observational

Summary: 
      The main aim of the present study is to examine eye-tracking based markers for social
      processing deficits in children with autism spectrum disorder (ASD). To this end a battery of
      five eye-tracking paradigms will be administered to young children with ASD and typically
      developing children. To additionally evaluate the specificity of the eye-tracking markers a
      group of children with disorders of delayed development other than ASD will be included.
    

Detailed description: 
      During an initial screening session all participants will undergo the Autism Diagnostic
      Observation Schedule (ADOS). ASD-related symptomatology and levels of impairments will be
      further characterized using the Social Responsibilities Scale 2 (SRS 2), Caregiver Strain
      Questionnaire (CSQ), Aberrant Behavior Checklist (ABC), Social Communication Questionnaire
      (SCQ), and Repetitive Behaviour Scale Revised (RBS-R).

      Subsequently all participants will be administered the following eye-tracking paradigms: (1)
      dynamic social and non-social visual preference paradigm during which dynamic geometric
      images (DGI) and dynamic social images (DSI) will be presented, (2) non-biological versus
      biological motion paradigm, (3) social attention and sharing of enjoyment paradigm, (4)
      preference for real versus schematic emotional face stimuli paradigm during which photographs
      of human faces and emoticons will be presented, (5) shared social attention and gaze
      direction paradigm.
    

Intervention name(s): Administration of five eye-tracking paradigms
Intervention type(s): Other
Intervention description(s): All subjects will undergo the battery of five eye-tracking paradigms to determine potential markers for autism.
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Children with ASD according to DSM-5 criteria will be compared with typically developing
        children and a group of children with unspecific delayed development disorders.
      
Keywords: eye tracking; visual preference
Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis
Condition: Ureteral Obstruction
MeSH terms: Hydronephrosis; Ureteral Obstruction
Study type: Observational

Summary: 
      The purpose of this study is to detect new urinary biomarkers that can be used as predictors
      on renal function in congenital hydronephrosis caused by unilateral ureteral obstruction
      (UUO) and to elucidate the pathophysiology of UUO.
    


Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Children referred to surgical treatment of congenital hydronephrosis caused by ureteral
        obstruction.
      
Biospecimen description: 
      Urine and frozen pelvic tissue
    
Keywords: Hydronephrosis; Ureteral obstruction
Single and Multiple Ascending Dose Study of V158866 in Healthy Volunteers
Condition: First in Man Study
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to investigate whether V158866 is safe when given to healthy
      male subjects in single and multiple doses.
    

Detailed description: 
      A first in human study:

      To evaluate the safety and tolerability of single and multiple doses of V158866 in healthy
      male subjects To assess the pharmacokinetics (PK) of V158866 in healthy male subjects To
      assess the pharmacodynamics (PD) of V158866 by determining whether V158866 inhibits fatty
      acid amide hydrolase (FAAH ) in healthy male subjects
    

Intervention name(s): V158866; V158866
Intervention type(s): Drug; Drug
Intervention description(s): Single ascending oral doses of V158866 and Placebo; Multiple ascending oral doses of V158866 and Placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Effect of Combined Intra-articular Injection of Lidocaine Plus Physiotherapy in Treatment of Frozen Shoulder
Condition: Frozen Shoulder; Adhesive Capsulitis
MeSH terms: Bursitis
Study type: Interventional

Summary: 
      1. Therapeutic exercise, especially stretch exercise and joint mobilization, remain the
           mainstay of conservative treatment of frozen shoulder.

             1. Nevertheless, shoulder pain during the physiotherapy reduces the treatment effect.

             2. Manipulation or arthroscopic release under general anesthesia may avoid pain during
                the intervention; however, increased risk of humeral shaft fracture and failure of
                release of pathological tissue were reported.

        2. We consider intra-articular injection is a compromized way, from a practical point of
           veiw, to reduce the pain during physiotherapy.

        3. We hypothesize that, intra-articular injection with lidocaine before joint mobilization
           and stretch exercise, can make the patient pain-free during physiotherapy, and the
           effect of combined therapy is superior to physiotherapy alone in the treatment of frozen
           shoulder.
    

Detailed description: 
      A randomized controlled trial to compare the effect in treatment of frozen shoulder between
      combined intra-articular injection with lidocaine plus physiotherapy and physiotherapy alone.
    

Intervention name(s): Lidocaine group; Physiotherapy (PT)
Intervention type(s): Procedure; Other
Intervention description(s): Patient position: prone position with arm under the abdomen and the elbow flexed to a right angle
Injection with a 25-gauge, 1.5-inch long needle fitted with 3ml syringe filled with 3ml 1% lidocaine.; - Include electric therapy, hot pack, followed by stretch exercise and joint mobilization
Other intervention name(s): Physiotherapy
Intervention MeSH terms: Lidocaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Adhesive capsulitis; Frozen shoulder; Shoulder pain; Intra-articular injection; Lidocaine injection; Physiotherapy; Manipulation; Stretch exercise
A Safety and Efficacy Study of a Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Patients With Hemophilia B
Condition: Hemophilia B
MeSH terms: Hemophilia A; Hemophilia B
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      This study will examine the safety, pharmacokinetics and efficacy of rIX-FP for the control
      and prevention of bleeding episodes in subjects who have previously received factor
      replacement therapy for hemophilia B.
    


Intervention name(s): rIX-FP
Intervention type(s): Biological
Intervention description(s): Recombinant IX-FP (rIX-FP) is a fusion protein linking coagulation factor IX with albumin, and will be administered by intravenous administration
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment