Inhibition Transcranial Random Noise Stimulation
Condition: Impulsive Behavior; Inhibition
MeSH terms: Impulsive Behavior
Study type: Interventional

Summary: 
      Inhibition control deficits is a major risk factor in the transition to the act in suicidal
      patients. Neuroimaging studies have shown that this failure was associated with hypoactivity
      in the prefrontal cortex (PFC), a brain area involved in the control of impulsivity. It was
      recently shown that a noninvasive brain stimulation session applied on the PFC reduces
      transiently impulsivity in healthy volunteers. Noninvasive brain stimulation modulates the
      activity and connectivity of neural network connected to the stimulation site. The
      investigators assume that a repetition of noninvasive brain stimulation sessions on the PFC
      will allow a more intense and longer lasting effect on impulsivity and cognitive control in
      healthy volunteers compared to a single session and to placebo stimulation. The investigators
      assume that this behavioral change will be accompanied by a change in brain activity measured
      by resting EEG for the patients in the active group. A more intense and longer lasting effect
      is an essential step to transfer these results to patient populations.

      The main objective is to study the effect of bilateral stimulation of the PFC by transcranial
      random noise stimulation (tRNS) on the inhibition control measured by the cognitive motor
      inhibition capacity (Go NoGo test). The secondary objectives are to study the effect of tRNS
      on verbal inhibition (measured with the Hayling test); on anxiety (measured with the
      State-trait anxiety inventory (STAI)),on angry (measured with the State-trait anger
      expression inventory (STAXI)) on verbal and nonverbal inhibition (measured by the Stroop
      test), on impulsive behavior (measured by the Barrat impulsiveness scale (BIS 10)) and on the
      neuronal electrical activity measured by EEG.
    

Detailed description: 
      Subjects are stimulated 3 times in a day. Each 20 minutes stimulation are separated by a
      period of at least 30 minutes. Before and after each stimulation, inhibition is evaluated by
      cognitive tests (Go Nogo test, Stroop test, Hayling test) and by the BIS 10 scale. During the
      stimulation, subjects compleat the STAXI and STAI scales. Cognitive tests are repeated 24
      hours and 8 days after the stimulation to evaluate duration of the effect. Possible side
      effects will be notified throughout the protocol.
    

Intervention name(s): transcranial random noise stimulation (tRNS) (Starstim)
Intervention type(s): Device
Intervention description(s): subjects are stimulated 3 times in a day by transcranial random noise stimulation (tRNS) (Starstim). each 20 minutes stimulation are separated by a period of at least 30 minutes. before and after each stimulation, inhibition is evaluated by cognitive tests: go nogo test, stroop test, Hayling test and by the BIS 10 scale. During the stimulation, subjects compleat the STAXI and STAI scales. Cognitive tests are repeated 24 hours and 8 days after the stimulation to evaluate duration of the effect. Possible side effects will be notified throughout the protocol.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment