bioihbjkbjnl/mcl2 huggingface dataset:
Gene Expression Profiling of Metastatic Breast Cancer Predict the Therapeutic Response to Chemotherapy
Condition: Breast Neoplasms; Neoplasm Metastasis
MeSH terms: Neoplasms; Neoplasm Metastasis; Breast Neoplasms
Study type: Observational

Summary: 
      The investigators want to develop a gene expression profile the for prediction the
      chemotherapeutic response of patients with metastatic breast cancer.
    

Detailed description: 
      1. Metastatic breast cancer tissue is obtained from core needle biopsies pretreatment and
           is flash frozen and stored at -70℃ until processing.

        2. After patients received docetaxel combination thiotepa for two cycles, response is
           assessed using Response Evaluation Criteria in Solid Tumor Group (RECIST) guidelines.
           Degree of response is used to divide the cancers into two groups-sensitive and resistant
           tumours.

        3. The gene expression in metastatic breast cancer tissue sample is detected by microarray
           to screen gene markers that are differently expressed between groups

        4. Statistical analysis is performed using unsupervised hierarchical cluster.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        female patients with metastatic breast cancer treated by Docetaxel-based chemotherapy
      
Biospecimen description: 
      the tissue will be obtained by core niddle biopsy.
    
Keywords: Metastatic Breast Neoplasms; Gene Expression Profiling; Drug Therapy
Domiciliary VR Rehabilitation
Condition: Hemiparesis; Functional Independence; Movement Disorder; Stroke
MeSH terms: Movement Disorders; Paresis
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether domiciliary VR-based telerehabilitation is
      superior than domiciliary occupational therapy for inducing functional gains, enhancing
      corticospinal excitability, and cortical reorganization.
    


Intervention name(s): Domiciliary VR-based motor rehabilitation; Domiciliary occupational therapy for motor rehabilitation
Intervention type(s): Behavioral; Behavioral
Intervention description(s): 3 weeks, 1 to 3 sessions a day, 20min per sessions, of physical therapy using a VR gaming system.; 3 weeks, 1 to 3 sessions a day, 20min per sessions, of physical therapy using a VR gaming system.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Mother-Infant Rapid Intervention at Delivery Telephone Outreach for Neonatal Therapy (TOT) Trial.
Condition: HIV
Study type: Interventional

Summary: 
      The Telephone Outreach for Therapy Trial was designed to test an intervention to assist new
      mothers or caregivers of HIV-exposed children with administering medication for the first 6
      weeks of life to prevent mother-to-child HIV infection in the infants. To be eligible,
      mothers of infants were identified as HIV-infected in the Mother-Infant Rapid Intervention at
      Delivery Study. Mothers or caregivers of infants were randomized into two groups: the
      intervention group received a cellular phone and scheduled twice daily calls to assure infant
      medications were given, and the other group received the current standard of care. Enrollment
      into the study was completed and analysis of the study data is underway.
    

Detailed description: 
      The Telephone Outreach for Therapy Trial was designed to test an intervention to assist new
      mothers or caregivers of HIV-exposed children with administering medication for the first 6
      weeks of life to prevent mother-to-child HIV infection in the infants. To be eligible,
      mothers of infants were identified as HIV-infected in the Mother-Infant Rapid Intervention at
      Delivery Study. Mothers or caregivers of infants were randomized into two groups: the
      intervention group received a cellular phone and scheduled twice daily calls to assure infant
      medications were given, and the other group received the current standard of care. Enrollment
      into the study was completed and analysis of the study data is underway.
    

Intervention name(s): Telephone Outreach for Therapy
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Measurement of Hemodynamic Responses to Lower Body Negative Pressure
Condition: Hypotension and Shock
MeSH terms: Hypotension
Study type: Interventional

Summary: 
      This study will be collecting data on participants undergoing lower body negative pressure
      (LBNP) to simulate progressive blood loss. The goal of the study is to collect data to allow
      for development of an algorithm with machine learning to predict blood pressure responses to
      hypovolemia by analyzing the arterial waveforms collected during LBNP.
    

Detailed description: 
      Death from exsanguination continues to be a major problem in combat casualty care and the
      care of civilians subjected to trauma. The ability to detect significant blood loss using
      traditional vital signs (heart rate, blood pressure) is marginal due to a variety of
      compensatory mechanisms that maintain blood pressure in the face of marked reductions in
      circulating blood volume. Along these lines, it is critical to develop monitoring devices and
      algorithms to non-invasively assess central blood volume in humans for the purposes of
      facilitating more timely interventions. The standard way to simulate hemorrhage in humans is
      to use Lower Body Negative Pressure (LBNP). In this technique, the lower body of a supine
      volunteer is enclosed in an airtight container while suction is applied to cause venous
      pooling in the legs and reduce central blood volume. This technique generates many
      physiological adaptations that are similar to that observed during blood loss studies in
      animals and human volunteers. Thus, the purpose of this study is to obtain data for use in
      developing monitoring technology to detect hemorrhage and other surrogate markers of central
      blood volume in humans.
    

Intervention name(s): Lower body negative pressure
Intervention type(s): Other
Intervention description(s): Simulated hypovolemia by applied suction to lower extremities to cause venous pooling.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Consequences of Hypoglycaemia on Cardiovascular and Inflammatory Responses
Condition: Hypoglycemia; Inflammatory Response; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypoglycemia; Diabetes Mellitus, Type 1
Study type: Interventional

Summary: 
      People with Type 1 diabetes (T1DM), type 2 diabetes (T2DM) and healthy volunteers will
      undergo a hypoglycaemic clamp to to investigate the effect of hypoglycaemia on cardiovascular
      and inflammatory responses.
    

Detailed description: 
      Objectives: The overall aim of the present study is to investigate the effect of
      hypoglycaemia on cardiovascular and inflammatory responses, molecular mechanisms and
      epigenetic profiles in various groups of people with diabetes type 1, type 2 and healthy
      volunteers.

      Study design: Intervention study

      Intervention: All subjects will undergo a hyperinsulinemic normoglycaemic-hypoglycaemic
      glucose clamp (nadir 2.8 mmol/L), during and after which blood and urine will be sampled for
      further examination for up to one week.
    

Intervention name(s): hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp
Intervention type(s): Procedure
Intervention description(s): For this study, a hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp will be conducted to investigate the effect of hypoglycaemia. This means that subjects will receive an intravenous insulin infusion, at a continuous rate of 60 mU∙m-2∙min-1, as well as glucose 20% w/w intravenously at a variable rate, adjusted by arterial plasma glucose levels, measured at 5 minute intervals.
Other intervention name(s): hypoglycaemic clamp
Intervention MeSH terms: Hypoglycemic Agents
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Physical Activity Level and Physical Activity Awareness
Condition: Physical Activity; Awareness
Study type: Observational

Summary: 
      It is important to determine the attitudes and behaviors of individuals towards regular
      exercise participation in order to direct individuals to physical activity or to implement
      effective practices related to increasing their participation.

      The aim of this study was to determine the awareness of physical activity in young adults,
      the relationship between physical activity awareness and physical activity level and to
      investigate the differences between sexes.
    


Intervention name(s): No intervention
Intervention type(s): Other
Intervention description(s): No intervention will be applied.
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        healthy volunteers
      
Keywords: physical activity level; physical activity awareness
Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)
Condition: Carotid Artery Stenosis; Glioma; Intracranial Aneurysm; Intracranial Hemorrhages; Brain Tumor
MeSH terms: Brain Neoplasms; Intracranial Aneurysm; Intracranial Hemorrhages; Carotid Stenosis; Aneurysm; Hemorrhage
Study type: Observational

Summary: 
      Plastic particles are a ubiquitous pollutant in the living environment and food chain, so
      far, plenty of studies have reported the internal exposure of microplastics and nanoplastics
      in human tissues and enclosed body fluids.

      Neurosurgery is the only department that can open the skull. In addition to blood and
      cerebrospinal fluid, there are brain tissue and tumors in the presence of lesions. Whether
      any of these microplastics and nanoplastics are present remains a mystery. This prospective
      observational study will harvest biological samples of neurosurgery patients.

      The objective of this research is to be able to detect microplastics and nanoplastics on
      blood and operation samples of neurosurgery patients.
    


Intervention name(s): biological samples analysis
Intervention type(s): Diagnostic Test
Intervention description(s): biological samples analysis
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Included patients age 18-80 years with any types of neurosurgery Excluded patients refuse
        to participate
      
Keywords: microplastics; nanoplastics; Intracranial Aneurysm; brain tumor; Carotid Artery Stenosis
Supreme LMA Use in Urgent Caesarean Section
Condition: Airway Morbidity
Study type: Interventional

Summary: 
      The Supreme Laryngeal Mask Airway (SLMA) is a single use supraglottic device that provides a
      good seal for positive pressure ventilation and good first attempt insertion rate of 98% in
      low risk patients undergoing elective Caesarean section. It has a double aperture design that
      facilitates the introduction of an orogastric tube to aspirate gastric contents.

      The primary study hypothesis is the first attempt insertion success rate of SLMA use in
      urgent Caesarean section.
    

Detailed description: 
      Investigators propose a prospective cohort study to study the first attempt insertion success
      rate of supreme LMA in general anaesthesia for urgent caesarean section.
    

Intervention name(s): Supreme Laryngeal Mask Airway
Intervention type(s): Device
Intervention description(s): Supreme Laryngeal Mask Airway. Preoxygenation, rapid sequence induction and cricoid pressure. Induction of general anaesthesia.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Airway, Caesarean
Essential Oils for Enhancing QOL in ASD
Condition: Autism Spectrum Disorder; Quality of Life; Sleep; Anxiety
MeSH terms: Autism Spectrum Disorder
Study type: Interventional
Phase: Phase 2

Summary: 
      Essential oils (aromatic oils extracted from plant parts) are routinely used by the public
      and are available on the market. Investigators are conducting this study because it is
      unknown whether the essential oils formulations will be safe and effective for improving
      quality of life in children with Autism Spectrum Disorder (ASD) by helping them relax and
      sleep.

      Children invited to participate in this study must be between 3-9 years of age and have been
      diagnosed with Autism Spectrum Disorder. Twenty eight children and their families will be
      enrolled in the study.

      Participants will try two different fragrant oils in a double-blind randomized order. Each
      child will receive each treatment for 3 months, with a 1-month "washout" period in between
      during which no oil is used.
    

Detailed description: 
      The purpose of the study is to evaluate the use of two fragrant oil formulations to enhance
      quality of life by increasing relaxation and sleep quality in children with Autism Spectrum
      Disorder (ASD). Essential oils (aromatic oils extracted from plant parts) are routinely used
      by the public and are available on the market. Investigators are conducting this study
      because it is unknown whether the essential oils formulations will be safe and effective for
      helping children with ASD relax and sleep.

      To participate in this study children must be between 3-9 years of age and have been
      diagnosed with Autism Spectrum Disorder. Approximately 40 children will be screened to enroll
      28 children and their families in the study.

      In a double-blind crossover study, participants will be randomized to treatment order. All
      participants will receive both fragrant oil blends. Those randomized will receive one
      fragrant oil blend for 3 months, with a 1-month "washout" period in between and then start
      the second fragrant oil blend in the last 3 months. The treatment orders are A/C and C/A.

      Study participation will last for 7 months. There will be one screening visit (about 5 hours
      long, which can be split into 2 visits), two baseline visits (about 2 hours each), two
      endpoint visits (2 hours each) and 5 other clinic visits (each 45-60 minutes). Visits will
      take place at the OSU Nisonger Center and the OSU General Clinical Research Center.
    

Intervention name(s): Reconnect; Coconut oil Comparator
Intervention type(s): Biological; Biological
Intervention description(s): Topical Essential Oils mixture and aromatic method; Topical Essential Oils mixture and aromatic method
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Relaxation
Intervention for Substance Use and Sexual Risk Behavior in Homeless Youth
Condition: Substance Use; Unprotected Sex
MeSH terms: Substance-Related Disorders
Study type: Interventional

Summary: 
      This study will evaluate a program called AWARE, which is a voluntary four session
      group-based motivational interviewing (MI) intervention to reduce substance use and sexual
      risk behavior among 18-25 year olds who are experiencing homelessness. The hypothesis is that
      participants who receive AWARE will show greater reductions in substance use and sexual risk
      behavior over a 12 month period compared to participants who do not receive the program.
    


Intervention name(s): AWARE
Intervention type(s): Behavioral
Intervention description(s): AWARE consists of four group sessions. The AWARE curriculum involves sharing basic information on sexually transmitted diseases; providing condom use skills training; providing normative feedback on substance use and sexual risk behavior among young adults; discussing unrealistic beliefs about substance use and sexual risk; discussing potential benefits of both cutting down and stopping risky behaviors; and discussing risky situations and coping strategies.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Prevention
A Trial to Test an Acceptance-based Therapy Program Among Adolescent Girls With Overweight/Obesity
Condition: Weight Loss; Obesity; Overweight
MeSH terms: Obesity; Overweight; Weight Loss
Study type: Interventional

Summary: 
      The purpose of this study is to investigate the effects of an acceptance-based therapy weight
      loss intervention compared with enhanced care for adolescents.
    

Detailed description: 
      Participants will complete baseline assessments and adolescents will be randomized to either
      an ABT weight loss intervention or enhanced care.

      The intervention will include 15 sessions over 6 months. Enhanced care will include 15
      healthy lifestyle handouts over 6 months.

      Post-treatment assessments will occur.
    

Intervention name(s): ABT Weight Loss Intervention; Enhanced Care
Intervention type(s): Behavioral; Other
Intervention description(s): This includes 15 sessions that are each 90 minutes in length. Intervention sessions will be weekly for the first 2 months, bi-weekly for the next 2 months, and monthly for the last 2 months.; This includes 15 handouts on elements of a healthy lifestyle and a midpoint one-on-one nutrition consultation with a registered dietitian.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: acceptance-based therapy; adolescents; weight; weight loss; obesity; overweight
Comparison of Usual Care and Distraction (Tablet) in Children 3-5 Years Old
Condition: Anxiety
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      Randomized control trial comparing usual care and distraction (tablet) on anxiety and length
      of stay between in children 3-5 years old
    

Detailed description: 
      Two group RCT comparing usual care and distraction (tablet) on preoperative anxiety and
      length of stay in preschool children.
    

Intervention name(s): Distraction; Usual care
Intervention type(s): Behavioral; Other
Intervention description(s): Distraction (interactive tablet); Anxiolytic ordered by anesthesiologist is usual care
Other intervention name(s): Anxiolytic per anesthesia
Intervention MeSH terms: Anti-Anxiety Agents
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Group 1: usual care Group 2: distraction
Masking: None (Open Label)
Primary purpose: Treatment
Effectiveness of Bubble Nasal Continuous Positive Airway Pressure (bCPAP) in Neonatal Respiratory Distress
Condition: Neonatal Respiratory Distress
MeSH terms: Respiratory Distress Syndrome, Newborn; Respiratory Distress Syndrome
Study type: Interventional

Summary: 
      The objective of study is to determine the effectiveness of bubble Continuous Positive Airway
      Pressure (bCPAP) in neonates presenting with respiratory distress as compared to the control
      group ( using oxygen via nasal cannula). The effectiveness will be calculated in terms of
      reduction in Silverman Anderson Retraction Score.
    

Detailed description: 
      After approval from the IRB of King Edward Medical University, and taking informed consent
      from parents of the participants, total of 120 neonates fulfilling inclusion and exclusion
      criteria will be enrolled and randomly allocated in two groups; group A and group B. All
      demographic details of participants in both groups be collected. In group A, neonates will be
      given bCPAP for respiratory support while neonates in group B, will be given nasal oxygen as
      control group. Neonates in both groups will be followed for 48 hours. The effectiveness will
      be determined by the reduction in Silverman Anderson Retraction Score (SARS) up to or less
      than 3, at the end of 48 hours. Data will be collected and analysed.
    

Intervention name(s): Bubble CPAP; Nasal Oxygen
Intervention type(s): Device; Other
Intervention description(s): The bCPAP will be delivered using an oxygen flow meter as the oxygen source. This inspiratory limb containing oxygen from the flow meter will be connected to humidifier and tubing from humidifier will be connected to short binasal prongs, which would be applied to neonate with the help of adhesive bandage on both cheeks. It will be ensured that binasal prongs make appropriate seal. An orogastric tube will be placed for gastric decompression. A 1000 ml/500ml bottle filled with sterile water be used and marks will be made on it at 1cm distance, with '10' marked at base and '0' mark at the water interface.
The expiratory limb from the nasal prongs was connected to tubing that will be dipped in water up to the desired level to provide positive end expiratory pressure. Pressure is varied by varying the depth of the dipped end of tubing.; The oxygen will be delivered from a wall oxygen source, delivered between 1 to 6 L/min and the rate varied via a flow regulator.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: bubble CPAP; respiratory distress; neonates; Silverman Anderson Retraction Score
Evaluation of Cardiac CT Appropriateness at Second-generation 320-row CT
Condition: Coronary Artery Disease; Cardiac CT
MeSH terms: Coronary Artery Disease; Myocardial Ischemia; Coronary Disease
Study type: Observational

Summary: 
      The influence of the second-generation 320-row area-detector CT (ADCT) on the clinical
      indications and appropriateness of cardiac CT has not been adequately investigated. The
      purpose of the survey is to assess the distribution of appropriateness ratings and test
      outcomes of cardiac CT with second-generation ADCT.
    


Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Consecutive patients referred for coronary CT angiography at our hospital
      
Keywords: Coronary artery disease; Cardiac CT; Appropriate Use Criteria (AUC)
An Investigation To Determine The Potential Interaction Effect Between GW876008 And Midazolam.
Condition: Healthy Subjects
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will evaluate any effect of single and repeated administration of GW876008 on the
      metabolism of midazolam in healthy volunteers.
    


Intervention name(s): midazolam; GW876008
Intervention type(s): Drug; Drug
Other intervention name(s): midazolam
Intervention MeSH terms: Midazolam
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Pharmacokinetics,; tolerability,; healthy,; subjects