Comparison of Thyroid Volumes in Patients With and Without Endometrioma
Condition: Endometrioma; Thyroid
MeSH terms: Endometriosis; Thyroid Diseases
Study type: Interventional

Summary: 
      The aim of our study is to evaluate whether there is a statistical difference between thyroid
      gland volume in patients with pathological diagnosis of endometriosis or endometrioma and in
      patients who underwent surgery for other gynecological reasons, and to reveal the presence of
      concomitant thyroid disease in these cases.
    

Detailed description: 
      Transcripts and proteins involved in thyroid metabolism are dysregulated in the eutopic and
      ectopic endometrium of endometriotic patients, leading to triiodothyronine (T3) action,
      resistance, and local thyroxine (T4) accumulation of the ectopic endometrium. Thyroid
      stimulating hormone (TSH) acts as a proliferative and prooxidative hormone in all
      endometriums of endometriosis patients and controls. Mouse studies have confirmed that
      endometriotic implants are larger when thyroid hormones are increased.

      Since endometriosis is characterized by a chronic inflammatory process, the high prevalence
      of autoimmune thyroid diseases in patients with endometriosis may be the result of immune
      dysregulation observed in women with endometriosis (5). Thyroid involvement has already been
      described in the physiology of the endometrium and ovary, and thyroid diseases are often
      associated with gynecological and obstetric disorders such as infertility, miscarriage or
      preterm delivery.

      Despite all the links between thyroid diseases and endometriosis, there is no study related
      to thyroid volume in patients with endometriosis so far. Thyroid volume was studied in
      patients with diabetes mellitus, pregnant women, and scleroderma. We believe that the
      evaluation of thyroid volume in patients with endometriosis will contribute to the
      investigation of the relationship between these two pathogenesis, and to the treatment and
      follow-up approach.
    

Intervention name(s): Evaluating Thyroid Volumes by ultrasonography
Intervention type(s): Other
Intervention description(s): The inclusion criteria are ; having a prediagnosis of surgically planned endometrioma and to undergo gynecological surgery for a reason other than endometriosis (control group). Among the patients with pre-diagnosis of endometriosis, who applied to our clinic during the study period and accepted to participate in the study, thyroid volumes will be measured by ultrasonography during the preoperative hospitalization. The pathological diagnosis of the patients will be confirmed and patients with different results will be excluded from the study (such as malignancy, endometriosis prediagnosis but different pathology detected etc.) In the same period, gynecological surgery was planned for another reason and patients without endometriosis will form the control group.
Other intervention name(s): routine blood tests, pathology data reports
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Screening