bioihbjkbjnl/mcl2 huggingface dataset:
Norketotifen for the Treatment of Uncomplicated Influenza-like Illness
Condition: Influenza -Like Illness
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a Phase 2b, multi-center, double-blind, randomized, placebo-controlled,
      parallel-group study of NKT versus placebo in otherwise healthy adults presenting with acute
      uncomplicated ILI due to influenza or other respiratory viruses in a community setting.
    


Intervention name(s): Norketotifen; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Oral capsule; Oral capsule
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Investigation of the Effect on Cognitive Skills of COVID-19 Survivors
Condition: COVID-19
MeSH terms: COVID-19
Study type: Interventional

Summary: 
      Investigation of the Effect Of Green Walking and Intelligence Games on the Cognitive Skills
      of Individuals Between the Ages of 50-70 Survived COVID-19 Disease

      The randomized controlled study to examine the effects of green walking and intelligence
      games on the cognitive skills of individuals aged 50-70 years who had COVID-19 on an
      outpatient basis were completed with 40 individuals, 20 of which were in the green walking
      and intelligence game group and 20 were in the control group.
    

Detailed description: 
      The data were collected in Erzincan Tercan State Hospital between January-May 2022, "Patient
      Information Form," "Montreal Cognitive Assessment Implementation Guideline," "Brain Games
      (Brain Games-Memory Thinking and Brain Exercise) Information Leaflet," "Hiking Information
      Brochure," and "Experimental Group Follow-up Form" by the "Montreal Cognitive Assessment
      Scale" applied as a pre-test. As an initiative, the green walking and intelligence game group
      was given a 30-minute nature walk three days a week for a month and a 15-minute intelligence
      game practice every day. Then, the "Montreal Cognitive Assessment Scale" was applied as a
      post-test.
    

Intervention name(s): green walking and intelligence gam
Intervention type(s): Other
Intervention description(s): The randomized controlled study to examine the effects of green walking and intelligence games on the cognitive skills of individuals aged 50-70 years who had COVID-19 on an outpatient basis were completed with 40 individuals, 20 of which were in the green walking and intelligence game group and 20 were in the control group.
Other intervention name(s): control
Allocation: Randomized
Intervention model: Single Group Assignment
Intervention model description: COVID-19 on an outpatient basis were completed with 40 individuals, 20 of which were in the green walking and intelligence game group and 20 were in the control group
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: COVID-19; Attention; Nature; Memory; Intelligence; Walking
Dexamethasone Versus Nalbuphine as Adjuvants in Brachial Plexus Block
Condition: Anesthesia
Study type: Interventional

Summary: 
      Brachial plexus block is a very reliable method of regional anesthesia for the upper limb. It
      achieves ideal operating conditions by producing complete muscular relaxation and stable
      intraoperative hemodynamics.However,Local anesthetics alone have a shorter duration of
      postoperative analgesia. Hence,various adjuvants have been added to local anesthetics to
      achieve quick, dense, and prolonged block. This study assess and compare the efficacy of
      dexamethasone or nalbuphine as adjuvants to local anesthetics in supraclavicular brachial
      plexus block for upper limb surgeries.
    

Detailed description: 
      Upper-limb surgeries can be performed under either general or regional anesthesia.However,
      regional anesthesia has the advantages of long-lasting pain relief & avoidance of airway
      instrumentation.Brachial plexus block is a very reliable method of regional anesthesia for
      the upper limb. It achieves ideal operating conditions by producing complete muscular
      relaxation and stable intraoperative hemodynamics.However,Local anesthetics alone have a
      shorter duration of postoperative analgesia. Hence,various adjuvants have been added to local
      anesthetics to achieve quick, dense, and prolonged block. This study assess and compare the
      efficacy of using 8 mg dexamethasone or 10 mg nalbuphine as adjuvants to local anesthetics
      mixture (Lidocaine 2% + bupivacaine 0.5% 1:1 mixture) in Ultrasound-guided supraclavicular
      brachial plexus block for upper limb surgeries below the level of the shoulder.
    

Intervention name(s): Ultrasound (US) guided supraclavicular brachial plexus block
Intervention type(s): Procedure
Intervention description(s): Using 8 mg dexamethasone or 10 mg nalbuphine as adjuvants to (Lidocaine 2% + bupivacaine 0.5% 1:1 mixture) in ultrasound (US) guided supraclavicular brachial plexus block
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo and Active Control in Major Depressive Disorder
Condition: Major Depressive Disorder
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 3

Summary: 
      This study is to evaluate that (SEROQUEL®) quetiapine sustained-release is efficacious and
      safe in the treatment of patients with MDD.
    


Intervention name(s): Quetiapine fumarate; Duloxetine
Intervention type(s): Drug; Drug
Intervention MeSH terms: Duloxetine Hydrochloride; Quetiapine Fumarate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: MDD; Quetiapine fumarate, sustained release; Depression
Phase 1 Study of DW-0919 & DW-0920 in Healthy Male Volunteers Under Fasting Condition
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate safety and pharmacokinetics of DW-0919 and DW-0920
      in healthy male volunteers under fasting condition.
    


Intervention name(s): DW-0920; DW-0919
Intervention type(s): Drug; Drug
Intervention description(s): Dosage form: Extended release tablet Dosage: 2 tablets; Dosage form: Extended release tablet Dosage: 1 tablet
Other intervention name(s): Acetaminophen: 325mg; Tramadol: 37.5mg; Wontran ER tab.; Acetaminophen: 650mg; Tramadol: 75mg
Intervention MeSH terms: Acetaminophen; Tramadol
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
GSK1349572 Exposure in Blood, Cervicovaginal Fluid, and Cervical and Vaginal Tissue in Healthy Female Subjects
Condition: Healthy Adult Females
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to describe drug concentrations of an investigational HIV
      medication, GSK1349572, in blood plasma, cervicovaginal fluid, vaginal and cervical tissue in
      HIV negative women.
    

Detailed description: 
      Purpose: The purpose of this study is to describe first dose and steady state
      pharmacokinetics of GSK1349572 in cervicovaginal fluid (CVF) and vaginal (VT) and cervical
      (CT) tissue compared to blood plasma (BP) in HIV-1 negative women. Based on current
      literature, GSK1349572 has demonstrated a desirable pharmacokinetic profile in BP, including
      low to moderate pharmacokinetic variability (CV% 9-41), extended t1/2 (13-15h) and trough
      concentrations which remain 25-fold higher than the protein-adjusted IC90 ~0.064µg/mL for
      wild type virus. Understanding pharmacokinetic behavior of GSK1349572 in multiple female
      biological compartments will inform its role in sterilizing the genital tract in HIV-infected
      women, as well as protect mucosal tissue against HIV infection (pre/post-exposure
      prophylaxis).
    

Intervention name(s): GSK1349572 (dolutegravir)
Intervention type(s): Drug
Intervention description(s): Subjects will take an oral daily 50mg dose of GSK1349572 for 5-7 days. GSK1349572 in the CVF and BP will be measured over 24 hours after both the initial dose, and once steady state is reached 5-7 days later at the following time points: 0 (pre-dose) 1, 2, 3, 4, 5, 6, 8, 12, 18, and 24h. Cervical and vaginal biopsies will be collected once at initial dose at either 3, 6, 12 or 24 hours post dose, and again at steady state at the same single time point. Samples will be collected from 2 subjects per time point. BP and CVF samples will be obtained at 48 and 72 hours following the final GSK1349572 dose.
Intervention MeSH terms: Dolutegravir
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Soiled Airway Tracheal Intubation and the Effectiveness of Decontamination by Paramedics
Condition: Airway Management; Intubation, Intratracheal; Laryngoscopy; Vomiting
MeSH terms: Vomiting
Study type: Observational

Summary: 
      In more than one-in-five cases of out-of-hospital cardiac arrest, airways are blocked by
      vomit and blood. Sometimes, paramedics cannot clear the airway using methods they have been
      taught. If the airway cannot be cleared, the patient will die.

      Usually, these patients will have a breathing tube placed into their windpipe (intubation),
      as this provides protection from vomit and blood. To do this, the paramedic needs to be able
      to see the entrance to the windpipe.

      A new method of clearing the airway called SALAD has been used in patients to help insert a
      breathing tube, but it is not known whether the method can help paramedics. This study will
      use a manikin to see if paramedics can insert a breathing tube more often on their first
      attempt, using SALAD.
    


Intervention name(s): Training in SALAD technique
Intervention type(s): Other
Intervention description(s): The training session will be delivered, and will take around 45 minutes to complete, including time for participant practice. The training intervention will adopt the Advanced Life Support Group/Resuscitation Council 4-stage approach of skills teaching, and is comprised of: A real-time demonstration of the SALAD technique by the researcher; A repeated demonstration with an explanation of the rationale of the steps taken when performing SALAD (not real-time); Another demonstration of the SALAD technique conducted by the researcher, but guided by one of the participants; An attempt by the same participant who guided the researcher in the previous step, followed by a practice attempt by the other participants.
Observational model: Case-Crossover
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Participants will be NHS staff who are employed by Yorkshire Ambulance Service NHS Trust,
        and who are Health and Care Professions Council (HCPC) registered paramedics.
Lidocaine Infusion in Radical Cystectomy
Condition: Postoperative Ileus
Study type: Interventional
Phase: Phase 2

Summary: 
      Radical cystectomy (RC) remains the gold standard for treatment of patients with muscle
      invasive bladder cancer, or recurrent high grade non-muscle invasive bladder cancer.
      Nowadays, enhanced recovery pathway is used to decrease morbidity and improve acute
      rehabilitation after RC. Postoperative ileus is the most frequent reason for prolonged
      hospital stay following cystectomy.
    

Detailed description: 
      Radical cystectomy remains the gold standard for treatment of patients with muscle invasive
      bladder cancer, or recurrent high grade non-muscle invasive bladder cancer. The high rates of
      morbidity and mortality reflect the fact that the majority of patients undergoing this
      procedure are elderly patients with multiple comorbidities. Postoperative ileus is the most
      frequent reason for prolonged hospital stay following cystectomy. To reduce the risk of
      ileus, prokinetics such as metoclopramide should be used postoperatively. Local anesthetics
      exert their actions as local anesthesia and antiarrhythmic through Na channels blocking but
      still have many other important actions through other receptors (e.g., m1 muscarinic
      receptors) that occur at very low plasma levels compared to levels needed for Na channels
      blocking, one of these actions is the anti-inflammatory effect against surgical stress
      response. Several randomized studies found that i.v. lidocaine shortens duration of
      postoperative ileus and some of it reported decreased postoperative pain with i.v. lidocaine,
      so they recommended i.v. lidocaine as a safe, simple, and less invasive method for management
      of postoperative ileus and equal to postoperative epidural analgesia.
    

Intervention name(s): Lidocaine; IV normal saline
Intervention type(s): Drug; Drug
Intervention description(s): IV Lidocaine infusion; IV normal saline infusion
Other intervention name(s): normal saline
Intervention MeSH terms: Lidocaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Pain and Stress Management for Fibromyalgia
Condition: Fibromyalgia
MeSH terms: Fibromyalgia; Myofascial Pain Syndromes
Study type: Interventional
Phase: Phase 2

Summary: 
      This interventional, randomized controlled study seeks to test the effects of an innovative
      emotional exposure and processing treatment that targets stress resolution, by comparing it
      with cognitive-behavioral therapy and a Fibromyalgia education comparison condition. The
      investigators also will test proposed mediators of the intervention, including improved
      autonomic regulation, and explore which subgroups of patients benefit the most from each
      approach.
    


Intervention name(s): Stress and Emotions; Thoughts and Behaviors; Brain and Body
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Focus on emotions, writing about stress, assertiveness training, role playing new ways to handle relationships, and sharing feelings and experiences with others.; Focus on cognitive and behavioral skills, such as relaxation, increasing pleasant activities, pacing, and changing ways of thinking.; Focus on the empowering patients by providing the latest scientific information about fibromyalgia, including causes, the role of the nervous system, and various treatments.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Fibromyalgia; Behavioral interventions; Psychological interventions
A Serosurvey Study of Hand, Foot, and Mouth Disease in Indonesia
Condition: Hand, Foot and Mouth Disease
MeSH terms: Foot-and-Mouth Disease; Hand, Foot and Mouth Disease; Mouth Diseases
Study type: Observational [Patient Registry]

Summary: 
      This study is a sero-survey study of infants aged 6 months to 71 months in Bandung City and
      West Bandung District. As initial data to find out how many children have been exposed to
      human enterovirus type 71 (HEV-71) which causes Hand, foot, and mouth disease (HFMD).
    

Detailed description: 
      This study is a cross-sectional seroprevalence survey of EV-71, associated with HFMD, among
      children aged between 6 to 71 months in Bandung, sampled from urban and rural Primary Health
      Center in Bandung, Indonesia. This study was implemented by Department of Child Health Hasan
      Sadikin General Hospital/Medical Faculty Universitas Padjadjaran Bandung, West Java.
      Age-stratified sample of 600 children aged 6-71 months will be conducted from these sites.
      Samples testing includes routine blood counts, enzyme-linked immunosorbent assays (ELISAs)
      for enterovirus type 71 (EV71) IgG and ELISAs for other HFMD-associated enteroviruses.
    

Observational model: Cohort
Time perspective: Other
Sampling method: Probability Sample
Study population: 
        The study population are children aged between 6 to 71 months in Bandung, sampled from
        urban and rural Primary Health Center in Bandung, Indonesia
      
Biospecimen description: 
      serum
Incidence of Occluded Culprit Arteries and Impact of Coronary Collaterals on Outcome in Patients With NSTEMI
Condition: NSTEMI
MeSH terms: Non-ST Elevated Myocardial Infarction
Study type: Interventional
Phase: Phase 4

Summary: 
      It is assumed that patients with non-ST-elevation myocardial infarctions (NSTEMI) showing an
      infero- or posterolateral occluded culprit artery (OCA) during diagnostic angiography
      frequently elude standard 12-lead electrocardiogram diagnosis. In addition, coronary
      collaterals may have beneficial effects in patients with OCA.
    

Detailed description: 
      We examined consecutive NSTEMI patients within 48 h of symptom onset. All patients underwent
      early invasive angiography plus optimal medical therapy. We compared baseline
      characteristics, procedural findings including analysis of TIMI-flow and collaterals using
      the Rentrop-classification, 30-day and 6-months major adverse cardiovascular events (MACE) in
      patients with and without totally OCA.
    

Intervention name(s): percutaneous coronary intervention
Intervention type(s): Procedure
Intervention description(s): early timing
Other intervention name(s): early invasive treatment strategy in NSTEMI
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: myocardial infarction; coronary occlusion; myocardial revascularization; collaterals; prognosis
Risk Reduction in Coronary Heart Disease
Condition: Coronary Heart Disease
MeSH terms: Heart Diseases; Coronary Disease; Coronary Artery Disease; Myocardial Ischemia
Study type: Interventional

Summary: 
      Study hypothesis: Multifactorial risk reduction in coronary heart disease can reduce the risk
      of new coronary heart disease and death
    


Intervention name(s): smoking cessation; betablocker, diuretics, ACEI, ARB,; statins, ezetimibe; training; influenza vaccine; metformin, glimepiride, insulin; weight reduction
Intervention type(s): Behavioral; Drug; Drug; Behavioral; Biological; Drug; Behavioral
Intervention description(s): NRT and varenicline; blood pressure control according to ESC guidelines; Cholesterol reduction according to ESC guidelines; daily walking; vaccine (FLuarix, Influvac etc); s.glucose control according to ESC guidelines; diet tips
Intervention MeSH terms: Metformin; Glimepiride; Ezetimibe; Diuretics
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Staff Nurse Perceptions of MBT Skills Training for Working With BPD in AMH
Condition: Borderline Personality Disorder
MeSH terms: Personality Disorders; Borderline Personality Disorder
Study type: Observational

Summary: 
      Despite expert opinion unconvinced of any value for hospitalization in caring for people with
      borderline personality disorder (BPD), this patient group still accounts for a significant
      proportion of adult acute mental health (AMH) admissions. Staff nurses generally voice
      negative perceptions of BPD, a view which is linked to an uncertainty of how to approach
      these patients, and difficulties leading to personal distress and burnout.
      Mentalization-based treatment (MBT) is an evidence based approach, focusing on the mental
      states of both self and others, developed specifically to treat BPD and facilitated
      successfully in specialised settings. MBT Skills training is a compact and cost effective two
      day workshop which equips generalist mental health nurses with a skillset enabling them to
      work effectively with BPD. MBT Skills training was first offered to staff nurses in Royal
      Cornhill Hospital, Aberdeen in 2013. This study aims to assess staff perceptions on the value
      of MBT skills training, evaluating how it impacts on clinical practice when working with BPD
      in AMH.
    

Detailed description: 
      Methodology: Using two focus groups with a neutral facilitator, a purposive sample of nine
      staff nurses took part in a semi-structured exploration of BPD in AMH. Participants discussed
      challenges with patients and the impact of MBT skills training and Clinical Supervision (CS).
      The focus groups were audio recorded and transcribed verbatim. Data was examined using a
      thematic analysis.
    

Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Staff nurses who had completed the 2 day Mentalization Based Treatment (MBT) skills
        training and were still working in acute mental health.
      
Keywords: Borderline Personality Disorder; Mentalization Based Treatment; MBT Skills Training; Staff Nurse Perceptions; Acute Mental Health
Alendronate Compared to Metformin in Chronic Periodontitis
Condition: Chronic Periodontitis
MeSH terms: Periodontitis; Chronic Periodontitis
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      This is a 9 month randomised controlled clinical comparing the clinical efficacy of
      1%metformin and 1%alendronate in chronic periodontitis subjects.
    

Detailed description: 
      ABSTRACT Background: Since Metformin (MF) induces osteoblast growth and differentiation while
      Alendronate (ALN) act as an antiosteolytic agent. The aim of the present study is to evaluate
      and compare the efficacy of 1% ALN and 1% MF gel as a local drug delivery system in adjunct
      to scaling and root planing (SRP) for the treatment of intrabony defects in patients with
      chronic periodontitis.

      Methods:

      The study had 3 groups comprising of ninety subjects, divided into three groups 1% MF with
      SRP, 1% ALN with SRP and placebo gel with SRP. Clinical parameters (plaque index (PI),
      modified sulcus bleeding index (mSBI), probing pocket depth (PPD), and clinical attachment
      level (CAL) were recorded at baseline, 3, 6 and 9 months. Radiographic parameters intrabony
      defect depth (IBD) and defect depth reduction (DDR%) was calculated on standardized
      radiographs by using image analysis software at 6 and 9 months
    

Intervention name(s): SRP plus Placebo Gel; SRP plus Alendronate gel; SRP plus Metformin gel
Intervention type(s): Drug; Drug; Drug
Intervention description(s): After SRP, placebo gel was delivered subgingivally into the pocket; Alendronate (ALN) After SRP, ALN gel was delivered subgingivally into the pocket; Metformin (MF) After SRP, MF gel was delivered subgingivally into the pocket
Other intervention name(s): Placebo; Alendronate gel; Metformin gel
Intervention MeSH terms: Alendronate; Metformin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: alendronate, metformin