bioihbjkbjnl/mcl2 huggingface dataset:
Therapeutic Effect of the Low FODMAP Diet in Children With Functional Abdominal Pain.
Condition: Functional Abdominal Pain Syndrome
MeSH terms: Abdominal Pain
Study type: Interventional

Summary: 
      Diet components are important factors in pathogenesis of functional gastrointestinal
      disorders, especially in the irritable bowel syndrome. Fermentable oligosaccharides,
      disaccharides, monosaccharides and polyols (FODMAP) are a group of short chain, poorly
      absorbed and osmotically active carbohydrates, which can induce gastrointestinal symptoms
      because of rapid fermentation in different segments of the gut. Low FODMAP diet is a novel
      treatment option with proven efficacy in reducing symptoms of functional gastrointestinal
      disorders in adults. Conversely, although functional abdominal pain is a common health
      problem in children, the efficacy of a low FODMAP diet remains understudied in this
      population.

      The aim of this study was to compare the effects of two diets: a low FODMAP diet and a diet
      based on standard dietary advice of the National Institute for Health and Care Excellence
      (NICE), on abdominal symptoms in children with functional abdominal pain.
    


Intervention name(s): The low FODMAP diet.; The diet based on NICE guidelines.
Intervention type(s): Other; Other
Intervention description(s): The low FODMAP group had reduced the intake of FODMAP. Children received 3 main meals and 2 snacks daily prepared by the catering company according to the Human Nutrition Recommendations for Polish Population. The dietary intervention lasted four weeks.; The control group based on NICE guidelines received diet contained products with different FODMAP content. Children received 3 main meals and 2 snacks daily prepared by the catering company according to the Human Nutrition Recommendations for Polish Population. The dietary intervention lasted four weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: low FODMAP diet; functional abdominal pain; children
Using Preimplantation Genetic Diagnosis in Autosomal Dominant Polycystic Kidney Disease Patients: a Multicenter Clinical Trial
Condition: Polycystic Kidney, Type 1 Autosomal Dominant Disease
MeSH terms: Arthrogryposis; Kidney Diseases; Polycystic Kidney Diseases; Polycystic Kidney, Autosomal Dominant
Study type: Interventional

Summary: 
      Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic hereditary
      kidney disease in humans. ADPKD may affect all the generations of the ADPKD family and the
      probability of ADPKD is 50% in the second generation for each gender. It has been confirmed
      that PKD1 and PKD2 are two pathogenic genes of ADPKD. Nowadays, the investigators have
      established an effective gene detection technology platform for PKD1/2 gene with long
      fragment PCR and next generation sequencing. First, the investigators performed genetic
      testing in patients with clinically diagnosed ADPKD and strong fertility desire, but afraid
      of hereditary risk. Using Preimplantation genetic diagnosis, including multiple annealing and
      looping-based amplification cycles amplification technique, the investigators successfully
      screened out healthy embryos by In Vitro Fertilization. Then the investigators transplanted
      embryos returned to the parent. When the baby is born, using umbilical cord blood gene
      detection, the investigators confirmed that the neonates do not inherit genetic defects form
      parents. The investigators have succeeded in one couple. The investigators design a
      multicenter clinical trial to confirm those procedures efficacy and safety.
    


Intervention name(s): Preimplantation Genetic Diagnosis
Intervention type(s): Procedure
Intervention description(s): Using Preimplantation genetic diagnosis, including multiple annealing and looping-based amplification cycles amplification technique, the investigators have had screened out healthy embryos by In Vitro Fertilization. Then the investigators transplanted embryos returned to the parent. Finally, participants will have healthy baby without pathogenic gene inheritance.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Allogeneic Stem Cells Implantation Combined With Coronary Bypass Grafting in Patients With Ischemic Cardiomyopathy
Condition: Coronary Artery Disease; Ischemic Cardiomyopathy
MeSH terms: Coronary Artery Disease; Myocardial Ischemia; Coronary Disease; Cardiomyopathies; Ischemia
Study type: Interventional
Phase: Phase 2

Summary: 
      The aim of the present study is to investigate safety and efficacy of intramyocardial
      implantation of a novel mesenchymal precursor cell type (iMP) in patients with ischemic
      cardiomyopathy at the time of coronary artery bypass grafting.
    

Detailed description: 
      This study aims to investigates in situ cardiac regeneration utilizing precision delivery of
      a novel mesenchymal precursor cell type (iMP) during coronary artery bypass surgery (CABG) in
      patients with ischemic cardiomyopathy (LVEF < 40 %). Preoperative scintigraphy imaging
      (SPECT) will be used to identify hibernating myocardium not suitable for conventional
      myocardial revascularization for iMP implantation. iMP cells will be implanted
      intramyocardially in predefined viable peri-infarct areas that show poor perfusion, which
      could not be grafted due to poor target vessel quality. Postoperatively, SPECT will be used
      to identify changes in scar area.
    

Intervention name(s): Intramyocardial implantation of of a novel mesenchymal precursor cell type (iMP).
Intervention type(s): Procedure
Intervention description(s): Intramyocardial implantation of a novel mesenchymal precursor cell type (iMP).
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: coronary artery disease; heart failure; stem cells implantation
Effect of Exercise Frequency on Metabolic Control and Heart Function in Type 2 Diabetes
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      This study will compare two interventions with the same exercise intensities and caloric
      expenditure but with different exercise frequency, on metabolic control and other risk
      factors in individuals with type 2 diabetes.
    


Intervention name(s): accumulated exercise; traditional exercise
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Exercise therapy; Time factors
Job-Seekers Training for Patients With Drug Dependence - 1
Condition: Substance-Related Disorders
MeSH terms: Substance-Related Disorders
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to examine the effectiveness of a 12-hour basic job-training
      program designed to give drug abuse treatment patients the skills they need to find and
      secure a job and set vocational goals and methods for locating employment. The intervention
      to be evaluated is modeled after the Job Seekers' Workshop, which was manualized and has been
      tested in trials.
    


Intervention name(s): Behavior Therapy
Intervention type(s): Behavioral
Allocation: Randomized
Keywords: behavioral intervention
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AK002
Condition: Indolent Systemic Mastocytosis
MeSH terms: Mastocytosis; Mastocytosis, Systemic
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a Phase 1 study to investigate the safety and tolerability of AK002 in patients with
      indolent systemic mastocytosis (ISM).
    


Intervention name(s): AK002
Intervention type(s): Drug
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: ISM; Mastocytosis; Indolent Mastocytosis
Pilot Study of Rituximab for the Treatment of Acute Immune Thrombocytopenic Purpura (ITP)
Condition: Purpura, Thrombocytopenic, Idiopathic
MeSH terms: Purpura; Purpura, Thrombocytopenic; Purpura, Thrombocytopenic, Idiopathic
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to assess the feasibility of a randomized, double blind, placebo
      controlled trial of add-on rituximab for non-splenectomized adults with acute immune
      thrombocytopenic purpura (ITP).
    

Detailed description: 
      Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by severe
      thrombocytopenia and bleeding. With current standard therapies, adult-onset ITP tends to
      recur thus exposing patients to prolonged risks of hemorrhage and toxicities of standard
      treatments. Rituximab, a chimeric anti-CD20 monoclonal antibody, has been shown to be
      effectively raise the platelet count in some patients with ITP and there is clinical and
      biological evidence to suggest that, if given early, rituximab may prevent ITP relapses.

      We have designed a randomized, double blind, placebo controlled pilot trial of rituximab for
      the treatment of non-splenectomized adults with acute ITP who are receiving standard
      treatments. The primary objectives of this trial are to determine the feasibility of
      recruitment, randomization and blinding; the safety of rituximab in ITP; and the event rate
      in the control group which will be used to calculate the sample size for a larger trial.
      Secondary objectives are to determine rates of 6-month event free survival where an event is
      defined as any of: a platelet count <50; the need for rescue treatment; or significant
      bleeding. Data from this pilot trial will inform the design of a larger phase III trial.
    

Intervention name(s): Rituximab; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 375mg/m2 per week for 4 consecutive weeks; Saline IV placebo once per week for 4 consecutive weeks
Other intervention name(s): Rituxan, Mabthera
Intervention MeSH terms: Rituximab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Idiopathic Thrombocytopenic Purpura; Rituximab; Feasibility study
Effect of Lugol's Solution in the Patients With Graves' Disease
Condition: Graves Disease
MeSH terms: Graves Disease
Study type: Observational

Summary: 
      Context: Although some of endocrine surgeons administer Lugol's solution to decrease thyroid
      gland vascularity, there is still no agreement on its effectiveness.

      Objective: The aims of this clinical trial are to evaluate thyroid blood flow and microvessel
      density in the patients with Graves' disease according to the Lugol's solution treatment
      preoperatively.

      Design: Retrospective clinical trial. Setting: A tertiary referral center. Method: Thirty-six
      patients were randomly assigned to preoperative medication with Lugol's solution. Patients in
      group 1 (n=17) received Lugol's solution for 10 days before surgical intervention, whereas
      patients in group 2 (n=19) didn't receive it.

      Main Outcome Measures: Blood flow through the thyroid arteries of patients with Graves'
      disease was measured by color flow Doppler ultrasonography. The microvessel density (MVD) was
      assessed immunohistochemically and Western blot analysis using the level of expression of
      CD-34 in thyroid tissue. The thyroid gland's weight and blood loss were measured in all
      patients.
    

Detailed description: 
      Thirty-six patients were randomly assigned to preoperative medication with Lugol's solution.
      Patients in group 1 (n=17) received Lugol's solution for 10 days before surgical
      intervention, whereas patients in group 2 (n=19) didn't receive it. Blood flow through the
      thyroid arteries of patients with Graves' disease was measured by color flow Doppler
      ultrasonography. The microvessel density (MVD) was assessed immunohistochemically and Western
      blot analysis using the level of expression of CD-34 in thyroid tissue. The thyroid gland's
      weight and blood loss were measured in all patients.
    

Intervention name(s): lugol's solution
Intervention type(s): Drug
Intervention MeSH terms: Lugol's solution
Time perspective: Prospective
Keywords: Graves' disease, Lugol's solution
A Trial of Robotic-assisted Versus Laparoscopic Abdominoperineal Resection for Treating Low Rectal Cancer
Condition: Rectal Cancer
MeSH terms: Rectal Neoplasms
Study type: Interventional

Summary: 
      In this study, the investigators assessed the difference in efficacy and safety among
      robotic-assisted versus laparoscopic abdominoperineal resection for patients with low rectal
      cancer.
    

Detailed description: 
      Patients will be eligible for inclusion if their primary tumors is low rectal cancer.

      Eligible patients will be randomly assigned to robotic-assisted (arm A) versus laparoscopic
      (arm B) abdominoperineal resection.
    

Intervention name(s): Robotic-assisted resection.; Laparoscopic resection
Intervention type(s): Procedure; Procedure
Intervention description(s): Robotic-assisted abdominoperineal resection.; Laparoscopic abdominoperineal resection
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Low rectal cancer; Robotic; Laparoscopic; Abdominoperineal resection
Motor, Non-motor and Genetic Determinants of Progression in Parkinson's Disease: A Mexican Multicenter Cohort Study
Condition: Parkinson's Disease
MeSH terms: Parkinson Disease; Disease Progression
Study type: Observational [Patient Registry]

Summary: 
      The objective of the study is to assess the effect of motor, non-motor and genetic factors on
      the progression of Parkinson's disease as well as its impact on complications rates.

      A large sample of Mexican subjects with Parkinson's disease attending several referral
      centers will be included.

      Data collected will include disease severity and motor scales, non-motor scales as well as
      genotyping for monogenic forms of the disease.

      Assessments will be performed every 6 months for two years.
    

Detailed description: 
      Demographic and clinical data will be collected after obtaining a signed informed consent.

      Recruitment will be competitive. Data collected includes age, gender, motor phenotype, age at
      onset, age at diagnosis, smoking history, family history, antiparkinsonic treatment, other
      treatments and a complete neurological evaluation.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Subjects diagnosed with idiopathic or genetic Parkinson's disease attending any of the
        participant sites in Mexico.
      
Biospecimen description: 
      Serum and/or saliva
    
Keywords: Parkinson's disease; Motor; Non-motor; Progression; Complications
Evaluation of Functional Status, Physical Activity and Quality of Life in Patients With Rotator Cuff Syndrome
Condition: Rotator Cuff Syndrome
MeSH terms: Syndrome; Rotator Cuff Injuries
Study type: Observational [Patient Registry]

Summary: 
      Pain is one of the most important factors affecting the quality of life. The quality of life
      of patients with pain and restricted shoulder movements can be affected in patients with
      Rotator Cuff Syndrome (RCS).
    

Detailed description: 
      The aim of our study is to examine the effect of the pain on functional status, quality of
      life and physical activity levels in daily life activities of RCS patients.
    

Intervention name(s): Quality of life and daily living activities assessment tests
Intervention type(s): Other
Observational model: Case-Only
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        This study was applied patients which were diagnosed with RC syndrome the Physical Therapy
        and Rehabilitation Department at Istanbul Medipol Mega University Hospital.
      
Keywords: Pain; Physical activity; Rotator cuff syndrome; Quality of life
Effects of Sterile Kinesio Tape on Anterior Cruciate Ligament Reconstruction
Condition: Postoperative Pain; Edema
MeSH terms: Edema
Study type: Interventional

Summary: 
      Anterior cruciate ligament reconstruction (ACLR) is a surgical tissue graft replacement of
      the anterior cruciate ligament, located in the knee, to restore its function after an injury.
      ACLR is used as the gold standard in coping with pain, deformity, and instability for the
      patients. The most important factors affecting the success of both surgery and postoperative
      rehabilitation programs are edema, joint movement limitation and pain around the knee in the
      early postoperative period. If these parameters are managed well in the postoperative period,
      the quality of life of the patient increases much earlier. In this respect, kinesio taping
      treatment, which is practical, comfortable, and safe for the patient, is one of the
      complementary treatment modalities with positive clinical results. No researchers have
      studied the effects of Sterile Kinesio Tape applied during ACL reconstruction on edema, pain
      and range of motion in immediate care postoperatively. The purpose of our study İS to assess
      effects of Sterile Kinesio Tape application on postoperative edema, pain and range of motion
      after ACLR within 72 hours. Thirty-seven patients who have undergone ACLR will be recruited
      to our study. Patients will be randomized into 2 groups; Group 1: Sterile Kinesio tape
      application, Group 2: Control group. All patients will be assessed for pain intensity (with
      Visual Analog Scale-VAS), edema (with tape measurement) and range of motion (with goniometric
      measurement-knee flexion/extension). Assessments will be done every day for 3 days (a total
      of 3 measurements). Group 1 will receive Sterile Kinesio Taping application within 72 hours
      applied with Sterile Web Cut Kinesio Tape without tension additional to standard during ACLR
      postoperative care. Group 2 will receive only standard postoperative care.
    


Intervention name(s): sterile kinesio taping
Intervention type(s): Other
Intervention description(s): Application area will be cleaned and dried prior to application to increase the adhesiveness of the tape and application will be done by an experienced physiotherapist during ACLR surgery.
Other intervention name(s): taping
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Patients are randomized into 2 groups; Group 1: Sterile Kinesio tape application (n=28), Group 2: Control group (n=28). Group 1 will receive Sterile Kinesio Taping application within 72 hours applied with Sterile Web Cut Kinesio Tape without tension additional to standard postoperative care. Group 2 will receive only standard postoperative care.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Kinesiotape; Anterior Cruciate Ligament Reconstruction; Edema; Pain; Range of Motion
A Randomized, Open-Label, Comparative 3-Way Treatment Crossover Study of 24-Hour Intragastric pH Profile of Once Daily Oral Administration of Esomeprazole 40mg, Lansoprazole 30mg, and Pantoprazole 40mg at Steady State in NSAID-Using Patients
Condition: Heartburn; Upper Abdominal Pain; Nausea; Acid Regurgitation
MeSH terms: Abdominal Pain; Heartburn
Study type: Interventional
Phase: Phase 4

Summary: 
      This study looks at controlling intragastric pH following administration of esomeprazole 40
      mg, lansoprazole 30 mg and pantoprazole 40 mg taken orally, once daily in patients taking
      either non-selective or cyclooxygenase-2 (COX-2) selective nonsteroidal anti-inflammatory
      drugs (NSAIDs).
    


Intervention name(s): Esomeprazole; Lansoprazole; Pantoprazole
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 40mg Oral; 30mg Oral; 40mg Oral
Other intervention name(s): Nexium; Prevacid; Protonix
Intervention MeSH terms: Esomeprazole; Pantoprazole; Lansoprazole; Dexlansoprazole
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Nexium; esomeprazole; lansoprazole; pantoprazole; Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Smart Technology for Weight Loss and Metabolic Health
Condition: Obesity; Overweight; Prediabetes; Weight Loss; Lifestyle
MeSH terms: Overweight; Prediabetic State; Glucose Intolerance; Body Weight; Weight Loss
Study type: Interventional

Summary: 
      The study will evaluate whether a technology-based lifestyle intervention program using
      primarily a smartphone platform is an acceptable and effective way for treating obesity. The
      goal of the program is to achieve weight loss and enhance the health of overweight or obese
      subjects by improving their diet and activity via smartphone applications as compared with
      conventional in-person weight management programs.
    


Intervention name(s): Wearable technology, smartscale; Smartphone applications; Standard Weight Management Visits
Intervention type(s): Device; Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Obesity; Overweight; Prediabetes; Smartphone application; Technology; Weight Loss; Lifestyle Intervention
WBV Training on Physical Function and Muscle Strength in Knee OA
Condition: Knee Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional

Summary: 
      In this study compare different frequencies of whole body vibration training on physical
      function and muscle strength in patients with knee osteoarthritis.
    

Detailed description: 
      This randomized controlled trial is to compare different frequencies of whole-body vibration
      (WBV) training on physical function and quadriceps muscle strength in patients with knee
      osteoarthritis and further will be researched which frequencies are effective for knee OA
      patients and how much WBV training is useful modality for knee osteoarthritic patients. This
      research will have significant effects in improving muscle strength and functional level of
      knee OA patients.
    

Intervention name(s): WBV technique; Whole body vibration technique
Intervention type(s): Other; Other
Intervention description(s): Whole body vibration with frequency of 16-25 Hz were given from week 1-8 for 10 minutes/10 repetitions. Time were increased weekly Convention therapy were hot pack 10 minutes, stretching exercise (SLR) 10 repetition x 3 sets and quadriceps exercise 10 repetition x 3 sets.
3 session/week for 8 weeks; Whole body vibration with frequency of 26-35 Hz were given from week 1-8 for 10 minutes/10 repetitions. Time were increased weekly Convention therapy were hot pack 10 minutes, stretching exercise (SLR) 10 repetition x 3 sets and quadriceps exercise 10 repetition x 3 sets.
3 session/week for 8 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Knee Osteoarthritis; Physical Function; Muscle Strength; Whole Body Vibration