THE EFFECT OF HELICOBACTER PYLORI ERADICATION THERAPY TO GASTRIC WALL THICKNESS BEFORE THE LAPAROSCOPIC SLEEVE GASTRECTOMY
Condition: Helicobacter Pylori Infection; Obesity, Morbid
MeSH terms: Obesity, Morbid
Study type: Interventional
Phase: Phase 4

Summary: 
      Laparoscopic sleeve gastrectomy is one of the most popular bariatric surgery in the world.
      The most important complication about this surgery that the leakage from the stapler line
      because of the inconvenient stapler choice..The stapler colour has to be chosen to the
      gastric wall thickness. It is not known well that the effect of Helicobacter pylori to
      gastric wall thickness Nobody pay any attention about being Helicobacter pylori positive when
      they are choosing stapler colour during the Laparoscopic sleeve gastrectomy so that everybody
      use the same type of stapler in Helicobacter pylori positive and negative patients during the
      Laparoscopic sleeve gastrectomy .Because of this inconvenient staplers use in the
      Laparoscopic sleeve gastrectomy the risk of leakage would be increase. Purpose of this
      research is that what is the effect of Helicobacter pylori to the gastric wall thickness and
      if the patients who will undergo Laparoscopic sleeve gastrectomy take the Helicobacter pylori
      eradication therapy before the surgery will gastric wall thickness increase or decrease. .
    

Detailed description: 
      All patients who will undergo to Laparoscopic sleeve gastrectomy have upper gastrointestinal
      system endoscopy before the surgery in our clinical routine. In our research some patients
      who has Helicobacter pylori positive endoscopic biopsy will take Helicobacter pylori
      eradication therapy one month before the surgery and some patients will not take any
      medication about Helicobacter pylori. All of gastric specimens( Helicobacter pylori positive
      or negative ) will examine microscopically in the pathology laboratory. The two groups which
      preoperatively Helicobacter pylori positive detected in endoscopic biopsy will compare with
      Helicobacter pylori negative control group. Control group will include 30 patients. The other
      two groups will include 44 patients for each group . The number of patients of group has been
      determined by power analysis. Gastric specimen will be examined by 3 points ; fundus, corpus,
      antrum. All of microscopic measurements will be done from that points from minor curvatura.
      These 3 points ; fundus( 1 cm from the top of staple line) , corpus (middle of the staple
      line) , antrum ( 1 cm far from the bottom of staple line ). All these points 5 mm far from
      the minor curvatura. These 3 points will examine about wall thickness (mucosa-
      submucosa-muscularis propria -serosa ) and the status of Helicobacter pylori. The end of the
      study it can be determined the effect of Helicobacter pylori to the gastric wall thickness.
    

Intervention name(s): Bismuth Subsalicylate
Intervention type(s): Drug
Intervention description(s): omeprazole 2x1) + clarithromycin 2x500 mg + amoxicilline 2x1000 mg + Bismuth Subsalicylate 2x1
Other intervention name(s): amoxicillin; clarithromycin; omeprazole
Intervention MeSH terms: Amoxicillin; Clarithromycin; Omeprazole; Bismuth; Bismuth subsalicylate
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: obesity; laparoscopic sleeve gastrectomy; helicobacter pylori; gastric wall thickness