Advanced Approach to Arterial Stiffness
Condition: Arterial Stiffness
Study type: Observational

Summary: 
      The aim of the 3A Study is to assess the role of MetS on the arterial mechanics and vascular
      health in different age groups using the Cardio Ankle Vascular Index (CAVI) of the Vasera
      system and the "classic" carotid-femoral Pulse Wave Velocity (PWV).
    

Detailed description: 
      Hypothesis The aim of thie 3A study is to assess the role of MetS on the arterial mechanics
      and vascular health in different age groups using the Cardio Ankle Vascular Index (CAVI) of
      the Vasera system and the "classic" carotid-femoral Pulse Wave Velocity (PWV).

      STUDY OBJECTIVES

        1. Objectives Primary Objective: Assess the influence of MetS on CAVI values (primary study
           endpoint) in 3 different age groups (40-54, 55-69, 70-85 years) of a European
           population.

        2. Secondary Objectives

             -  Establish the CAVI values in a European population according to the clusters of
                (MetS) components i.e. cardiovascular risk factors: abdominal obesity, high
                triglycerides, low HDL cholesterol, elevated blood pressure (BP), systolic or
                diastolic, and elevated fasting glucose (and diabetes), as well as tobacco smoking.

             -  Assess the correlation between CAVI and the carotid-femoral PWV in the full
                population and in each age group; and compare the impact of MetS and its components
                on both the CAVI and PWV

             -  To establish, the relationship between cardiovascular risk factors and the
                evolution of arterial stiffness as evaluated by CAVI and carotid-femoral PWV over a
                2-year follow-up period.

             -  To assess changes and predictive value of CAVI on organ damages and CV events
                during the follow-up period.

             -  To assess 24h ABPM and its correlations and variations with the CAVI and PWV in
                patients with MetS and/or its different components.

      This is a multinational European prospective longitudinal study.
    

Intervention name(s): Cardio Ankle Vascular Index (CAVI) of the Vasera system VS1500N
Intervention type(s): Device
Intervention description(s): CAVI will be measured using the Vasera device (VS1500 n - Fukuda Denshi co, Japan). This device is easy to use and calculates automatically the CAVI.
CAVI measurements will be performed according to the manufacturer Measurements will be performed after five to ten minute - period of rest in order to obtain a steady hemodynamic state and to limit measurements variability.
Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        All patients aged 40-85 with life expectancy over 2 years will be included. Patients will
        be stratified according to their age (3 groups: 40-54, 55-69, 70-85 years)) and the
        presence or not of MetS.
      
Keywords: Cardio ankle vascular index; CAVI; pulse wave velocity; PWV; Non invasive arterial structure assessment