bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Naturalistic Decision-Making Model-based Oncofertility Care Education
Condition: Fertility Issues; Breast Cancer; Education
MeSH terms: Breast Neoplasms; Infertility
Study type: Interventional

Summary: 
      his study examined the effects of an oncofertility education program on decisional conflict
      in nurses caring for breast cancer patients and patients with breast cancer. Other predictors
      of decisional conflict were also examined.
    

Detailed description: 
      Background: Nurses play an essential role in transferring knowledge to patients. However,
      several factors cause nurses to adopt a negative attitude toward providing oncofertility
      care.

      Objective: This study examined the effects of an oncofertility education program on
      decisional conflict in nurses caring for breast cancer patients and patients with breast
      cancer. Other predictors of decisional conflict were also examined.

      Design: Randomized, controlled experimental research. Settings and Participants: Patients
      (61) with breast cancer and nurses (79) were recruited from a hospital in Taipei, Taiwan.

      Methods: The nursing participants were randomly assigned to receive oncofertility education
      (experimental group) or usual education (control group). Data from female patients in the
      control and experimental groups were collected before and after the nurses' educational
      training, respectively. The oncofertility education consisted of one face-to-face educational
      session and reading one educational booklet based on the Naturalistic Decision-Making (NDM)
      Model. The decisional conﬂict was measured using the Chinese version of the decisional
      conﬂict scale.
    

Intervention name(s): Naturalistic Decision-Making Model-based Oncofertility Care Education
Intervention type(s): Other
Intervention description(s): We designed the education program according to Klein's NDM model, which explored the reasoning mechanism behind decision-making (Klein, 1993). It depends on the on-the-job training date in each unit. The education program consisted of the following: (1) Information accumulation: explanations of common cancer therapies related to subsequent infertility, psychological and mental change in cancer survivors with infertility, the necessity and method of early determination of fertility intention, and type of fertility preservation. (2) Sense-making: situational case sharing, emphasis on the guidance interaction between experienced and novice nurses to understand the patient's situation. (3) Decision-making: how to provide support, how to correspond, and attitudes toward people with strong fertility intention.
Intervention model: Single Group Assignment
Intervention model description: This study examined the effects of an oncofertility education program on decisional conflict in nurses caring for breast cancer patients and patients with breast cancer.
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Education; Decisional Conflict; Breast Cancer; Nurse; Oncofertility
Anti-hypertensive Medication Dosing Regimen in Effective Blood Pressure Control
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional
Phase: Phase 4

Summary: 
      A randomised crossover trial of anti-hypertensive medication dosing regimen in effective
      blood pressure control.

      To investigate whether there is a difference in 24 hour blood pressure (BP) control when
      antihypertensive medications are taken in the morning compared with the evening.
    

Detailed description: 
      The identification of any significant difference could lead to more effective therapeutic
      management of arterial hypertension, which in turn would result in a reduced cardiovascular
      burden, lower costs and a better quality of life for hypertensive patients.
    

Intervention name(s): Anti-hypertensive Medication -
Intervention type(s): Drug
Intervention description(s): Patients will be taking their routine blood pressure lowering medication prescribed by their GP, different patients will be using different blood pressure lowering medication.
Dosing regimen either in the morning (between 06.00 and 11.00) or in the evening (between 18.00 and 23.00).
Other intervention name(s): PR1 Diruetics; PR3 Beta Blockers; PR4 Calcium channel blockers; PR5 ACE inhibitors; PR6 Angiotensin II Receptor Blockers; PR7 Centrally acting agents; PR8 Alpha blockers; PR9 Direct Renin Inhibitors; PR10 Vasodilators
Intervention MeSH terms: Antihypertensive Agents; Calcium Channel Blockers; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Angiotensin Receptor Antagonists; Renin Inhibitors
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Hypertension
The Effect of Two Different Massages on Migraine
Condition: Headache, Migraine; Manuel Therapy
MeSH terms: Migraine Disorders; Headache
Study type: Interventional

Summary: 
      The study aims to compare the effects of connective tissue massage on pain severity, attack
      frequency and duration, migraine-related disability, and quality of life in patients
      diagnosed with migraine, by comparing them with the classical massage.
    


Intervention name(s): Connective tissue massage; Classical massage
Intervention type(s): Other; Other
Intervention description(s): Connective tissue massage will be applied with short and long pulling strokes to create a reflex effect for 2 days a week, a total of 8 weeks.; Classical massage will be applied with the techniques of stroking, kneading, and friction for 2 days a week, a total of 8 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
A Two-Week Crossover Dispensing Evaluation Of Orion Daily Wear Soft Contact Lens
Condition: Myopia
MeSH terms: Myopia
Study type: Interventional

Summary: 
      The primary objective of the study is to evaluate the clinical performance of test lens
      (Orion) in comparison with control lens (Gemini) over a period of two weeks of wear.
    

Detailed description: 
      The primary objective of the study is to evaluate the clinical performance of test lens
      (Orion) in comparison with control lens (Gemini) over a period of two weeks of wear. This is
      a double-masked, randomized, bilateral, two-week crossover, dispensing study.
    

Intervention name(s): Orion daily disposable contact lens; Gemini daily disposable contact lens
Intervention type(s): Device; Device
Intervention description(s): Subjects will be randomized to wear Orion lens for 2 weeks.; Subjects will be randomized to wear Gemini lens for 2 weeks.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Resistance Exercise, Recovery Drinks and Appetite
Condition: Active Population
Study type: Interventional

Summary: 
      Whilst the effects of manipulating the macronutrient content of foods on appetite and energy
      intake has been relatively well studied at rest, little is known about these responses in a
      post-exercise context. The effect of post-exercise nutrition on recovery from or adaptation
      to exercise has been well studied. However, many exercisers do so for weight management and
      thus any post-exercise nutrition might impact on energy balance and might need to be
      carefully considered. This study will examine the impact of manipulating the composition of a
      recovery drink consumed after resistance exercise on subsequent appetite and energy intake.
    

Detailed description: 
      Subjects perform a bout of lower body resistance exercise lasting ~50 min and immediately
      post-exercise they consume one of two recovery drinks over a 5 min period. Over the next 60
      min subjective appetite responses will be measured and then 60 min after drink ingestion,
      subjects will consume an ad-libitum meal.
    

Intervention name(s): Protein drink; Carbohydrate drink
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): The protein drink was administered during this trial; The carbohydrate drink was administered in this trial
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
The Effect of Melatonin Administration on Sedation Level as Adjuvant to Propofol
Condition: TBI (Traumatic Brain Injury)
MeSH terms: Brain Injuries; Brain Injuries, Traumatic
Study type: Interventional
Phase: Phase 3

Summary: 
      This study assess the effect of administration of exogenous melatonin as adjuvant to propofol
      on the level of sedation and consequently the rate of propofol infusion.
    

Detailed description: 
      38 patients with traumatic brain injuries requiring mechanical ventilation and sedation were
      randomly allocated to two groups (melatonin group)19 patients and (control group)19 patients.
      In both groups a bolus of propofol 1mglkg was given by titration till the patient reached a
      sedation level value of (60-70) on the bispectral index (BIS), Then propofol infusion started
      at a rate of 1mglkglhr as a maintenance and rate adjusted according to our targeted sedation
      level, melatonin 10 mg tablet was crushed and mixed with 20 ml of water and administrated
      through a nasogastric tube followed by another 20 ml to flush out the residue for (melatonin
      group). While (control Group) received a placebo tablets by the same wayBIS value and
      propofol infusion rate was recorded over 12 hours.
    

Intervention name(s): Melatonin 10 MG Oral Tablet; Propofol; Placebo oral tablet
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Melatonin tablets; propofol amp; sugar pill manufactured to mimic melatonin tablets
Other intervention name(s): circadian; diprivan; palacebo tabletes (for melatonin)
Intervention MeSH terms: Propofol; Melatonin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: melatonin
Treatment of PAD by Platelet Lysate for Therapeutic Angiogenesis
Condition: Critical Limb Ischemia
MeSH terms: Peripheral Arterial Disease; Chronic Limb-Threatening Ischemia; Ischemia
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Induction of autologous angiogenesis in patients with critical limb ischemia using platelet
      lysate.
    

Detailed description: 
      Ten male and female patients diagnosed with Peripheral artery disease (PAD), will be
      recruited. This diagnosis will be based on medical history, physical examinations, laboratory
      tests, and specific diagnostic tests. Patients qualified for this study, are patients with
      distal extremity ischemia indicated by claudication and rest pain present for a minimum of 4
      weeks without evidence of improvement in response to conventional drug therapy; showed
      angiographic evidence of PAD in the affected limb; and were not candidates for surgical
      revascularization. Platelet lysate will be injected intramuscularly at different sites of the
      gastrocnemius muscle. The purpose of this study is to evaluate the safety and efficacy of
      platelet lysate injections into ischematic limbs of patients with PAD.
    

Intervention name(s): Platelet lysate
Intervention type(s): Biological
Intervention description(s): Autologous intramuscular platelet lysate injection for patients with peripheral arterial disease
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Platelet lysate; Critical limb ischemia; Peripheral arterial disease
Effects of Core Stabilization and Strengthening Exercise on Quality of Life in Clinical Lumbar Instability
Condition: Chronic Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      This study will compare the effects of 2 exercise programs including core stabilization
      exercise and general trunk strengthening exercise programs on trunk muscle activity, physical
      dysfunction, quality of life and lumbar motion in low back pain patient with clinical lumbar
      instability.
    

Detailed description: 
      Clinical lumbar instability is the one of causes of chronic low back pain, that affects to
      pain intensity and quality of life. For clinical studies using core stabilization exercise
      (CSE) as treatment have revealed conflicting findings on pain, functional disability and
      muscle responses in chronic low back pain. The CSE promotes local muscle system that to
      provide lumbar stability. However, the stability of spine related to global muscle system,
      that using in this study.
    

Intervention name(s): Core Stabilization Exercise; General Strengthening Exercise
Intervention type(s): Other; Other
Intervention description(s): the participants asked to performed CSE program, 20 min/session, 2 session/week, 10 weeks; the participants asked to performed GSE program, 20 min/session, 2 session/week, 10 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Detecting Lung Infections Through Vibration
Condition: Lung Infection
MeSH terms: Infections; Communicable Diseases
Study type: Observational

Summary: 
      The purpose of this study is to test a lung air vibrator device for vibrating air inside the
      lung. This exploratory diagnostic trial will test a novel and non-invasive means of detecting
      lower airway infections using exhaled breath sample.
    

Detailed description: 
      This study has two phases. Once the subject has consented phase 1 will start by the subject
      breathing air out of their lungs into the device. Next, the subject will simply breathe
      through the mouthpiece with the machine turned on and take samples of exhaled air.

      In phase 2, the subjects will breathe air out of their lungs into the device for 15 minutes.
      Next, the subject will simply breathe through the mouthpiece with the machine turned on and
      take samples of exhaled air for 15 minutes.
    

Intervention name(s): Group 1 will receive 15 Hz; Group 2 will receive 30 Hz; Group 3 will receive 60 Hz; Group 4 will receive 100 Hz; Phase II Optimal Frequency
Intervention type(s): Procedure; Procedure; Procedure; Procedure; Procedure
Intervention description(s): Group 1 (n=30), these subjects will receive 10 minutes of High Frequency Oscillation at 15 Hz at .75 cm on day 1. Then will have a 24 hour washout. On day 2 will receive 10 minutes of low Frequency Oscillation at 15 Hz at 1.25 cm.; Group 2 (n=30), these subjects will receive 10 minutes of High Frequency Oscillation at 30 Hz at .75 cm on day 1. Then will have a 24 hour washout. On day 2 will receive 10 minutes of low Frequency Oscillation at 30 Hz 1.25 cm.; Group 3 (n=30), these subjects will receive 10 minutes of High Frequency Oscillation at 60 Hz .75 cm on day 1. Then will have a 24 hour washout. On day 2 will receive 10 minutes of low Frequency Oscillation at 60 Hz at 1.25 cm.; Group 4 (n=30), these subjects will receive 10 minutes of High Frequency Oscillation at 100 Hz at .75 cm on day 1. Then will have a 24 hour washout. On day 2 will receive 10 minutes of low Frequency Oscillation at 100 Hz at 1.25 cm.; Participants in Phase II will undergo 10 minutes of HFO at the optimal frequency as determined during Phase I.
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Healthy normal adults age 18 to 50 Individuals with cystic fibrosis
      
Keywords: cystic fibrosis
A Study to Evaluate the Effect of 2 Drugs on the Pharmacokinetics of BMS-986205 in Healthy Subjects
Condition: Malignancies Multiple
MeSH terms: Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      Assess the effects of itraconazole and rifampin on the pharmacokinetics, safety, and
      tolerability of BMS-986205.
    

Detailed description: 
      A randomized, open-label, parallel design study in healthy participants to assess the effects
      of itraconazole and rifampin on the single-dose pharmacokinetics of BMS-986205. Safety and
      tolerability data to be collected and assessed as well.
    

Intervention name(s): BMS-986205; Itraconazole; Rifampin
Intervention type(s): Drug; Drug; Drug
Intervention description(s): BMS-986205; Oral solution; Tablet
Intervention MeSH terms: Itraconazole; Rifampin; Linrodostat
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Scandinavian Urethroplasty Study
Condition: Urethral Stricture
MeSH terms: Urethral Stricture
Study type: Interventional

Summary: 
      A multicentre, prospective, randomized study comparing bulbar urethroplasty with excision and
      primary anastomosis or with an onlay grafting procedure using buccal mucosa.
    

Detailed description: 
      The study is a prospective, randomized study to compare two common techniques of
      urethroplasty used to treat bulbar urethral strictures. One technique is excision of the
      stricture and end-to-end anastomosis of the urethra. The other technique is an onlay grafting
      procedure with buccal mucosa where the corpus spongiosum is not divided. The study is
      designed to compare complications of sexual and penile function, and is not powered to
      compare the success rates of the two techniques. The primary endpoint will be degree of
      erectile dysfunction and penile complications. The secondary endpoint will be restricturing
      leading to reoperation, and other complications.
    

Intervention name(s): End-to-end; Graft
Intervention type(s): Procedure; Procedure
Intervention description(s): Excision of the stricture and end-to-end anastomosis of the urethra.; Incision of stricture and grafting procedure with buccal mucosa where the corpus spongiosum is not divided
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: operative technique
Acidophilus for the Treatment and Prevention of Oral Candidiasis in Patients Undergoing Radiation Therapy
Condition: Oral Candidiasis
MeSH terms: Candidiasis; Candidiasis, Oral
Study type: Interventional

Summary: 
      The purpose of this study is to determine the effectiveness of using acidophilus to treat
      oral candidiasis (thrush) caused by radiation therapy to the head and neck region.

      This study will conducted in two parts. In the first part of the study, two participants will
      begin radiation therapy. When signs and symptoms of thrush are noted, such as smooth, creamy,
      white/yellow coating and/or patches on the tongue and inside of your mouth that are painful,
      you will begin taking acidophilus capsules twice each day until the last day of radiation
      therapy.

      The second part of the study is to determine if acidophilus is effective in preventing oral
      candidiasis (thrush) during radiation therapy to the head and neck region. In the second part
      of the study three participants will take acidophilus capsules twice each day beginning on
      the first day of radiation therapy and continuing until the last day of radiation therapy.
    

Detailed description: 
      To determine if Lactobacillus acidophilus ,Ritzman Natural Health Acidophilus supplements
      given twice daily during radiation treatments to the head and neck region after the
      development of oral thrush is an effective treatment for oral candidiasis.

      To determine if Lactobacillus acidophilus ,Ritzman Natural Health Acidophilus supplements
      given twice daily beginning on the first day of radiation treatments to the head and neck
      region prevents the development of oral thrush.

      To assess subjective and objective response of oral candidiasis treated with Lactobacillus
      acidophilus ,Ritzman Natural Health Acidophilus supplements.

      To assess the efficacy of Lactobacillus acidophilus ,Ritzman Natural Health Acidophilus
      supplements in preventing oral candidiasis in patients receiving radiation therapy to the
      head and neck region.
    

Intervention name(s): Acidophilus; Acidolphilus
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Use of Acidophilus in the first part of the study, two participants will begin radiation therapy. When signs and symptoms of thrush are noted, such as smooth, creamy, white/yellow coating and/or patches on the tongue and inside of their mouth that are painful, subjects will begin taking acidophilus capsules twice each day until the last day of radiation therapy.
The second part of the study is to determine if acidophilus is effective in preventing oral candidiasis (thrush) during radiation therapy to the head and neck region.; The second part of the study is to determine if acidophilus is effective in preventing oral candidiasis (thrush) during radiation therapy to the head and neck region.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: thrush
Integrative Personal Omics Profiling for Dynamic Molecular Phenotypes Monitoring During Fiber Supplementation
Condition: Prebiotics
Study type: Interventional

Summary: 
      The investigators propose a comprehensive, multiomic study that will integrate longitudinal
      data associating changes in specific gut bacteria and host in response to prebiotic fiber
      supplementation. These data will guide the development of an integrative biological signature
      relating bacterial-derived metabolites with biological outcome in the host.
    

Detailed description: 
      With this study, the investigators propose to assemble a cohort of healthy individuals that
      will receive prebiotic supplementation, during comprehensive, longitudinal characterization
      of the microbiota and host changes with clinical markers and multiple omics assays. These
      multiomic data will then be integrated, generating unique biological signatures that define
      the role that microbial metabolites from specific bacteria play in host biological activity.
      Through this study the investigators expect to gain a detailed and clear understanding of the
      physiological changes, at the mechanistic level, that occur in the microbiome and host in
      response to dietary supplementation with prebiotic fiber.
    

Intervention name(s): Dietary fiber supplementation
Intervention type(s): Dietary Supplement
Intervention description(s): Randomization to the order of first fiber: either inulin or arabinoxylan. Third cycle will include a mix of 5 fibers: inulin, arabinoxylan, resistant starch, glucomannan, and acacia gum.
Intervention model: Sequential Assignment
Intervention model description: Participants will be randomized to start fiber supplementation with one type of fiber for three weeks. After a washout period, they will supplement with the second type of fiber for an additional 3 weeks.The third cycle will be the same for all participants and they will supplement with a mix of 5 fibers for 3 weeks.
Masking: Single (Participant)
Primary purpose: Basic Science