bioihbjkbjnl/mcl2 huggingface dataset:
Success Rate of the Miniscrews in the Mandibular Buccal Shelf
Condition: Class III Malocclusion
MeSH terms: Prognathism; Malocclusion; Malocclusion, Angle Class III
Study type: Interventional

Summary: 
      Stability of the orthodontic miniscrews placed in the mandible is still considered to bare
      higher risk of failure compared to other intraoral locations. The aim of our study was to
      determine the influence of the miniscrew size on their long-term stability, occurrence of
      oral mucosa inflammation and pain lasting over 48 hours after implantation.
    


Intervention name(s): Orthodontic miniscrew insertion in the mandibular buccal shelf
Intervention type(s): Procedure
Intervention description(s): Each patient received miniscrews in both sizes. The same orthodontist (M.S.) performed all the insertion procedures. Miniscrews were always placed in the mandibular buccal shelf, laterally to the first and second molar interproximal area, with angulation 30 degree to the bone surface, meaning that miniscrew angulation should be approximately the same as the axial inclination of the adjacent molar. Miniscrews were loaded with orthodontic force 2 weeks after the surgery. The investigated factors were:
long-term success rate of the miniscrews in the buccal shelf of the mandible (miniscrews were considered long-term stable if they served as an anchorage until completion of mandibular distalization, at least 9 months);
peri-implantitis development (enlargement of the gingiva and/or redness and/or tendency to bleed);
the patient's report of pain lasting longer than 48 hours after miniscrew insertion.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 200 Absoanchor® miniscrews (Dentos, South Korea) in two sizes: SH2018-10 (length 10 mm, ø 18-20 mm) and SH1514-08 (length 8 mm, ø 14-15 mm) were inserted in the mandibular buccal shelf of 100 Caucasians aged 20-50 years, diagnosed with Class III malocclusion that required en-masse distalization of the mandibular dentition. We designed our project as a split-mouth study, therefore each patient received both SH2018-10 and SH1514-08 miniscrews. The same orthodontist (M.S.) inserted the screws near the muco-gingival junction, following one surgical protocol. Miniscrews were loaded with orthodontic force (NiTi coil springs) of approximately 200 g, two weeks after the surgery. On the same visit patients were surveyed upon pain incidence lasting longer than 48 hours. Then TISAD stability and soft tissue condition were closely examined at each appointment. Miniscrews were considered long-term stable if they served as an anchorage until completion of distalization of the mandibular teeth.
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: miniscrew; orthodontics; skeletal anchorage
Transcranial Magnetic Stimulation for Borderline Personality Disorder
Condition: Borderline Personality Disorder
MeSH terms: Personality Disorders; Borderline Personality Disorder
Study type: Interventional

Summary: 
      Primary purpose : to assess the effect on neuropsychological tasks related to planning of 10
      daily sessions of right dorsolateral prefrontal cortex with High-frequency repetitive
      transcranial magnetic stimulation (rTMS) on borderline personality disorder (BPD) patients.

      Hypothesis : BPD patients receiving 10 sessions of rTMS will have greater improvement in the
      average number of move to achieve tasks of the Tower of London, than those receiving sham
      rTMS.
    


Intervention name(s): repetitive Transcranial Stimulation Magnetic (rTMS); sham rTMS
Intervention type(s): Procedure; Procedure
Intervention description(s): The motor threshold was determined in each subject once, before treatment. This was defined as the lowest stimulation intensity capable of inducing a visible movement at least five times out of 10 stimulations. The position of the right dorsolateral prefrontal cortex was defined as 5 cm anterior (in a parasagittal line) to the motor cortex. The stimulus intensity was 80% of the patient's motor threshold intensity. Treatments were given for 20 minutes per day over 10 working days.; sham rTMS
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Borderline Personality Disorder; Transcranial Magnetic Stimulation; Neuropsychological Test; Randomised Control Trial
Clinical Utility of Neuromodulation on Tinnitus
Condition: Tinnitus
MeSH terms: Tinnitus
Study type: Observational

Summary: 
      The aim of the present narrative review is to one of the first to critically evaluate the
      clinical effectiveness of neuromodulation as a therapeutic option for patients with tinnitus.
      Our method involves conducting a systemic review and the findings reported following PRISMA
      statement. Pubmed, Cochrane database and Google Scholar databases literature search was
      conducted for articles reporting the use of neuromodulatory interventions on tinnitus
      patients. Each article was evaluated using the Cochrane risk of bias tool.
    


Observational model: Other
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        Tinnitus patients
Treatment of Alcohol Withdrawal in Hospital Patients
Condition: Alcohol Withdrawal Syndrome
MeSH terms: Substance Withdrawal Syndrome
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to test how tolerable and effective lorazepam is when used to
      treat alcohol withdrawal in hospital patients at risk for alcohol withdrawal.
    

Detailed description: 
      Studies show that symptom-triggered dosing is best for treatment of alcohol withdrawal in
      patients on chemical dependence units without other illness. On general medical hospital
      wards, withdrawal may be affected by comorbid medical illness. A clinical trial was
      undertaken to determine whether there is a difference between symptom-triggered (ST) and
      fixed-schedule (FS) dosing of lorazepam in patients hospitalized on general medical wards at
      a University medical center. Subjects were assessed by their nurses with the Revised Clinical
      Institute Withdrawal Assessment for Alcohol (CIWA-Ar) scale. Subjects in the ST arm received
      lorazepam doses based on CIWA-Ar score. Subjects in the FS arm received scheduled lorazepam
      with tapering over 4 days.
    

Intervention name(s): Lorazepam (drug); Lorazepam
Intervention type(s): Drug; Drug
Intervention description(s): Lorazepam administered orally or IV for treatment of alcohol withdrawal in hospitalized patients; Lorazepam administered orally or IV for treatment of alcohol withdrawal in hospitalized patients
Other intervention name(s): Ativan; Ativan
Intervention MeSH terms: Lorazepam
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Alcohol withdrawal; Symptom-triggered therapy; Fixed-schedule therapy; CIWA-Ar; Lorazepam (drug)
Cartilage Adaptation and Response to Interleukins and Exercise
Condition: Osteo Arthritis Knee
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional

Summary: 
      This study will examine the effect of exercise on the turnover of collagen in articular
      cartilage and the content of cytokines in the synovial fluid from human adults with
      osteoarthritis.
    

Detailed description: 
      By using stabile isotope labelling, this study will track the formation and destination of
      newly formed cartilage collagen in adult humans scheduled for knee replacement surgery due to
      osteoarthritis. The collagen formation as well as the effect on the cytokine content of the
      synovial fluid will be examined both at rest and in response to 4 weeks of exercise/training.
      Overall the project aims to improve the basic understanding of cartilage development and
      function in relation to osteoarthritis prevention.
    

Intervention name(s): Exercise.
Intervention type(s): Behavioral
Intervention description(s): Moderate to heavy intensity resistance exercise consisting of leg press.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Basic Science
Keywords: exercise; cytokines; collagen
Quality of Analgesia After Interscalene Block After Arthroscopic Shoulder Surgery
Condition: Injury of Shoulder Region
MeSH terms: Shoulder Injuries
Study type: Interventional

Summary: 
      Shoulder arthroscopic causes post operative pain that outlasts analgesia provided by single
      injection nerve blocks.
    

Detailed description: 
      The interscalene brachial plexus block (ISBPB) is a common analgesic technique for procedures
      of the shoulder and upper arm.

      Moreover, the incidence of rebound pain is well documented and is often of considerable
      discomfort to patients, who may quickly go from little or no pain to moderate-severe pain.
      Continuous nerve block techniques with home ambulatory catheters are currently utilized to
      manage postoperative pain.This study is designed to compare the level and duration of pain
      control of Exparel® injected after bupivacaine via stop-cock connected syringes and
      bupivacaine alone for ISBPB.
    

Intervention name(s): Exparel block in arthroscopic shoulder surgery; Bupivacaine block in shoulder surgery
Intervention type(s): Drug; Drug
Intervention description(s): The interscalene block will be performed with ultrasound guidance and nerve stimulation.; The interscalene block will be performed with ultrasound guidance and nerve stimulation.
Other intervention name(s): ISBPB with bupivacaine and Exparel; ISBPB with bupivacaine alone
Intervention MeSH terms: Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Study for Pre-Surgical Weight Loss in Type II Diabetes Patients
Condition: Type 2 Diabetes; Obesity
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2; Weight Loss
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine whether the GI Sleeve is safe and effective in
      treating Type II diabetes patients
    

Detailed description: 
      Patients with obesity are at significantly greater risk of developing complications such as
      pulmonary dysfunction, diabetes, hypertension, and other co-morbid risks. NIH panel
      recommendations state that even a 10% short-weight loss would greatly reduce these risks. GI
      Dynamics' GI Sleeve represents a viable alternative to other short-term pre-surgical weight
      loss methods. GI Sleeve is a device that can be implanted and removed through minimal
      invasive endoscopic techniques. This endoscopic procedure brings potential benefits to
      patients in that it is minimally invasive, efficacious, and allows patients to recover faster
      with less morbidity and mortality.
    

Intervention name(s): GI Liner
Intervention type(s): Device
Intervention description(s): Medical device placed endoscopically in the duodenum, nutritional counseling
Other intervention name(s): GI Endobarrier Liner
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Type 2 Diabetes
The Efficacy of Pilates in the Recovery of Post-prostatectomy Urinary Incontinence
Condition: Prostate Cancer; Urinary Incontinence
MeSH terms: Urinary Incontinence; Enuresis
Study type: Interventional

Summary: 
      The purpose of this study is to compare the efficacy between a Pilates exercise program and a
      Pelvic Floor Muscle Training (PFMT) protocol combined with anal electrical stimulation (AES)
      in the recovery of urinary continence (UI) after radical prostatectomy.

      There are no studies that evaluate Pilates mat exercises for incontinence in men although it
      can be assured that this method has the pelvic floor contractions as a principle for
      practice. If this new therapeutic approach proves to be as effective as described treatment
      in improving urinary complaints, it will be an option for patients who prefer a non-invasive
      treatment.
    

Detailed description: 
      This randomized clinical trial includes 69 individuals with urinary incontinence one month
      after radical prostatectomy. One physiotherapist, with experience in urogynecology, was
      responsible for all the assessments. Urinary frequency, nocturia, 24-hour pad test, number of
      pads used per day, and the International Consultation on Incontinence Questionnaire - Short
      Form (ICIQ-SF) were the variables evaluated.

      The subjects were allocated in one of two treatment groups (G1: Pilates; G2: anal electrical
      stimulation combined with pelvic floor muscle training). Volunteers participated of 10
      sessions of the corresponding treatment and were reassessed objectively by the number of pads
      used per day, and subjectively with the score of quality of life.
    

Intervention name(s): PILATES; PFMT and AES
Intervention type(s): Other; Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Prostatectomy; Urinary Continence; Physical Therapy Modalities; Pelvic Floor; Randomized Trial.
Effectiveness of Varenicline: Testing Individual Differences
Condition: Smoking Addiction
MeSH terms: Behavior, Addictive
Study type: Interventional
Phase: Phase 4

Summary: 
      The study will evaluate the effectiveness of smoking cessation using Varenicline versus
      placebo. Effectiveness will be measured by the average number of cigarettes smoked per
      smoking day for up to 36 weeks.
    


Intervention name(s): Placebo; Varenicline
Intervention type(s): Drug; Drug
Intervention description(s): 25mg look alike riboflavin tablets to match active study medication.; Days 1-3 - .5mg tablet 1xdaily Days 4-7 - .5mg tablet 2xdaily Days 8-84 - 1mg tablet 2xdaily
Other intervention name(s): riboflavin; Chantix
Intervention MeSH terms: Riboflavin; Varenicline
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Clinical Efficacy of Virtual Reality During Office Hysteroscopy and Endometrial Biopsy in Subfertility
Condition: Infertility, Female
MeSH terms: Infertility; Infertility, Female
Study type: Interventional

Summary: 
      This study is a comparison between the current standard practice of performing a diagnostic
      hysteroscopy and a relatively recently developed technology that is added to the standard
      diagnostic hysteroscopy. The aim of the study is to find out whether this newer technology
      has an advantage for the patient, in the form of anxiety and pain reduction.
    


Intervention name(s): Oncomfort, commercially available Virtual Reality headset
Intervention type(s): Device
Intervention description(s): Virtual Reality headset, consisting of headphones with smartphone glasses - see oncomfort.com/en, CE approval conform 93/42/EEC and 2007/47/EEC
Allocation: Randomized
Intervention model: Single Group Assignment
Intervention model description: This study is a comparison between the current standard practice of performing a diagnostic hysteroscopy and a relatively recently developed technology that is added to the standard diagnostic hysteroscopy. The aim of the study is to find out whether this newer technology has an advantage for the patient, in the form of anxiety and pain reduction.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: virtual reality; hysteroscopy; infertility
Randomized Controlled Trial on Uptake of NHS Health Checks
Condition: Cardiovascular Diseases
MeSH terms: Cardiovascular Diseases
Study type: Interventional

Summary: 
      The National Health Service (NHS) Health Check is a significant part of the strategy to
      tackle premature mortality and promote healthy lifestyles. Public Health England aspires to
      an uptake rate of 75% but national uptake is less than 50%. This study aims to assess the
      impact of two new behaviourally informed NHS Health Check leaflets on the uptake of NHS
      Health Checks, by randomizing patients in Lewisham and North East Lincolnshire to the
      different leaflets and comparing patient-level uptake data. The study will test whether a
      shorter risk-framed leaflet or a shorter benefits-framed leaflet will be more effective than
      the current national leaflet at encouraging uptake of the NHS Health Check.
    


Intervention name(s): risk-framed leaflet; benefits-framed leaflet; current national leaflet
Intervention type(s): Other; Other; Other
Intervention description(s): 2-sided leaflet, emphasizing health risks of not going to the NHS Health Check; 2-sided leaflet, emphasizing benefits of attending an NHS Health Check; 4-sided leaflet
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Positron Emission Tomography (PET) During Radio-chemotherapy to Treat Otorhinolaryngological Cancer
Condition: Malignant Neoplasm of Head and Neck; Locally Advanced Malignant Neoplasm
MeSH terms: Neoplasms; Head and Neck Neoplasms
Study type: Interventional

Summary: 
      Open multicentric study assessing predictive value of 18-FDG PET (SUV max) at 20 Gy during
      radio-chemotherapy, on the loco-regional control after 2 years
    


Intervention name(s): Positron emission tomography; radiochemotherapy
Intervention type(s): Device; Radiation
Intervention description(s): Every patients will be treated with radiochemotherapy as a standard of care
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Human Fibrinogen Concentrate in Pediatric Cardiac Surgery
Condition: Hypofibrinogenemia; Afibrinogenemia; Bleeding Disorders
MeSH terms: Hemostatic Disorders; Blood Coagulation Disorders; Afibrinogenemia
Study type: Interventional
Phase: Phase 4

Summary: 
      The goal of the study is to determine whether the use of Human Fibrinogen Concentrate
      (RiaSTAP) will decrease blood loss and the need for component blood therapy in neonates and
      infants undergoing cardiopulmonary bypass.
    

Detailed description: 
      The goal of the study is to determine whether the use of Human Fibrinogen Concentrate
      (RiaSTAP) will decrease blood loss and the need for component blood therapy in neonates and
      infants undergoing cardiopulmonary bypass. RiaSTAP will be administered after termination of
      Cardiopulmonary Bypass (CPB) at a dose of 70 mg/kg, in a prospective, randomized, controlled
      study. We hypothesize that the administration of RiaSTAP in this manner will reduce
      peri-operative bleeding and transfusion requirements.
    

Intervention name(s): RiaStAP; Saline
Intervention type(s): Drug; Drug
Intervention description(s): To decrease post-operative bleeding volume.; Placebo consisting of normal saline 0.9%
Other intervention name(s): Fibrinogen Concentrate Human; Normal Saline 0.9%
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: CBP, congenital heart defects, cardiopulmonary bypass
Quality of Life in Children Glaucoma and Cataract
Condition: Paediatrics With Cataracts; Paediatrics With Glaucoma
MeSH terms: Glaucoma; Cataract
Study type: Observational

Summary: 
      The management of childhood glaucoma (CG), childhood cataract (CC) and other birth defects
      affecting the eyes requires frequent hospital attendances and often multiple surgical and
      medical interventions, and are often associated with poor vision. Chronic medical conditions
      and vision impairment can affect quality of life (QoL). The QoL of children with the above
      conditions has not previously been evaluated.
    

Detailed description: 
      We wish to evaluate health related and vision related quality of life (HRQoL, VRQoL) in
      children age 2 to 16 years with childhood glaucoma (CG), childhood cataract (CC) and
      congenital eye defects microphthalmia, anophthalmia or coloboma (MAC).

      We will recruit children who attend the children's eye clinics at Moorfields Eye Hospital at
      City Road. We will include the following subgroups:

      A) children with primary or secondary glaucoma B) children with cataract or previously
      treated for cataract C) children with microphthalmia, anophthalmia or coloboma D) control
      group: agematched children without eye and vision problems. We will ask children and their
      carers to complete two age appropriate, validated questionnaires, the PedsQL (health related
      quality of life) and the Cardiff Visual Ability Questionnaire for Children. From the medical
      notes, we will record diagnosis and best corrected visual acuity with both eyes open. We will
      also record details of previous and current treatment, such as number of previous surgical
      interventions (sum of interventions right and left eye) and number of current topical
      medications (sum of eyedrop applications per day right and left eye).
    

Intervention name(s): Quality of Life questionnaire
Intervention type(s): Other
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        We will recruit children who attend the children's eye clinics at Moorfields Eye Hospital
        at City Road. We will recruit children with healthy eyes and normal vision amongst the
        siblings who accompany new patients in Child Vision Clinics and the paediatric A&E. This
        approach will ensure that families have not previously been burdened with frequent hospital
        appointments.
Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of Simotinib Hydrochloride in Healthy Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to assess the safety and pharmacokinetics of single ascending
      doses of Simotinib Hydrochloride in healthy subjects.
    


Intervention name(s): Simotinib Hydrochloride; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Single ascending doses: 25 mg、50 mg、100 mg、150 mg、225 mg、300 mg、400 mg、500 mg、600 mg、750 mg; Single ascending doses: 150 mg、225 mg、300 mg、400 mg、500 mg、600 mg、750 mg
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment