bioihbjkbjnl/mcl2 huggingface dataset:
Programme Evaluation on Effectiveness of The Use of Movement-based x 'Elderspirituality - Fu Le Mun Sum' Intervention to Support Elderly People With Depressive Symptoms
Condition: Depression in Old Age
MeSH terms: Depression
Study type: Interventional

Summary: 
      Depression is one of the most common mood disorders in old age, and yet it is frequently
      under-detected and under-treated. Adopting a train-the-trainer approach, this project intends
      to utilize the dance movement therapy (DMT), as intervention, to support elderly people with
      depressive symptoms.
    

Detailed description: 
      In the present project, two evaluation studies will be conducted. The first study will
      evaluate the effectiveness of a train-the-trainer approach provided to frontline art
      development officers who will subsequently conduct interventions for the elderly. A
      participatory train-the-trainer approach will be adopted to develop a new intervention
      protocol by integrating body-movement therapeutic elements and a spiritual well-being
      enhancement group. In the second study, a quasi-experimental design will be adopted to
      examine the effectiveness of the Movement-based x 'Elderspirituality - Fu Le Mun Sum'
      intervention to support elderly people with depressive symptoms.
    

Intervention name(s): Dance Movement Therapy (DMT)
Intervention type(s): Behavioral
Intervention description(s): The main Dance Movement Therapy (DMT) methods were dance-movement improvisations, body awareness exercises, and reflection through drawing/painting, writing, and verbalization. There was an orientation to personal space and body awareness, interaction in pairs, and interaction in the whole group. The themes included exploration of boundaries, somatic resources, symbols, pleasant and unpleasant emotions, mindfulness, and body awareness, enriched movement experiences, and safety and touch. In the present study, it consists of six sessions, including (1) Movement for Self-expression, (2) Movement for Emotional Health I, (3) Movement for Emotional Health II, (4) Movement for Connection & Creativity, (5) Embracing your Dancing Child, and (6) Movement for Self-compassion.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: It is proposed that a total of 140 participants will be recruited, with 70 assigned to the intervention group, and 70 to the active control group. For the active control group, health talk will be delivered to participants which will match the length of contact and interval of contact of that in the intervention group. For the intervention group, dance movement therapy will be delivered on a regular basis.
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: Depression; Dance Movement Therapy; Depressive symptoms; Older adults; Elderly; Ageing
The Effect of Customized Insoles on Biomechanics and Pain in Patients With Functional Flatfoot
Condition: Flexible Flatfoot
MeSH terms: Flatfoot
Study type: Interventional

Summary: 
      The aim of present study is to compare the effects of 3D printing customized insoles using
      different thermoplastic materials on functional flatfoot patients' foot function and
      biomechanics
    

Detailed description: 
      Functional flatfoot is a common foot disease which induces pain and functional decline.
      Insoles can be used for intervention and correction, especially customized insoles which are
      made according to different foot types. There have been few studies using 3D printing for
      customized insoles for functional flatfoot. Besides, compared to traditional method and
      subtractive manufacturing, the effect of 3D printing customized insoles is still
      controversial and depends on technology, materials and design.The purpose of present study is
      to compare the effects of 3D printing customized insoles using different thermoplastic
      materials on functional flatfoot patients' foot function and biomechanics. Twelve patients
      with functional flatfoot (foot function index> 6) aged 20-65 years old will be recruited in
      this study. Participants plan to wear three kinds of customized insoles fabricated by 3D
      printing with Nylon and TPU or computer numerical control machine with EVA. F-Scan system and
      questionnaires will be used to record foot biomechanics and pain after wearing insoles
      immediately, and foot condition after three weeks. Statistical analysis will be adopted for
      repeated-measures analysis of variance （ANOVA） for all outcome measures and post-hoc test
      will be used to test the difference between groups.
    

Intervention name(s): Insole
Intervention type(s): Device
Intervention description(s): 3D printing insole (Nylon), 3D printing insole (TPU), CNC machine insole (EVA), shoe only
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect Of Cough Assist Device On Hemodynamic Status And Oxygen Saturation For Ventilated Children
Condition: Pneumonia Childhood; Intensive Care Unit; Children
MeSH terms: Pneumonia
Study type: Interventional

Summary: 
      Statement of the problem:

      •Is there an effect of the cough assist device on Hemodynamic status and oxygen saturation
      for ventilated children? Null hypothesis There will be no effect of cough assist device on
      hemodynamic status and oxygen saturation for ventilated children.
    

Detailed description: 
      Subjects:

      The study targets the children from both sexes.diagnosed with pneumonia in intensive care
      unit. Sample size estimation will be carried out to determine the recruited number of
      children, selected randomly from Cairo University pediatric specialized hospital, Cairo to
      participate in the study.

      Study design:

      Randomized controlled clinical trial. Children will receive intervention type randomly,25
      child will receive traditional chest physical therapy (postural drainage, percussion and
      vibration, end expiratory pressure) and bed mobility exercise.and the other 25 child will
      receive cough assist device in addition to traditional chest physical therapy (postural
      drainage, percussion and vibration, end expiratory pressure) and bed mobility exercise.

      Children will be assessed by measuring heart rate, respiratory rate, blood pressure which
      reflect the physiological status, oxygen saturation,expired Tidal Volume and dynamic lung
      compliance which reflect clinical improvement of chest condition before and after receiving
      intervention
    

Intervention name(s): Cough assist device
Intervention type(s): Device
Intervention description(s): Cough assist device Cough Assist clears secretions from the lungs by gradually applying positive air pressure to the airway and then rapidly shifting to negative air pressure . The resulting high expiratory flow simulates a deep, natural cough.
Designed chest physical therapy Percussion, vibration, end expiratory pressure and bed mobility exercise.
Other intervention name(s): Designed chest physical therapy
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Assignment
Masking: Single (Participant)
Primary purpose: Treatment
The Effect of Non-surgical Periodontal Therapy on the Gingival Crevicular Fluid Levels of Prolactin Hormone in Patients With Periodontitis.
Condition: Periodontitis; Prolactin in GCF
MeSH terms: Periodontitis
Study type: Interventional

Summary: 
      The present study will be conducted on fifty participants. All participants will receive a
      full-mouth clinical examination, and the following periodontal parameters will be recorded:
      Plaque Index (PI). Gingival Index (GI), probing depth (PD), and clinical attachment level
      (CAL). All of these measurements will be recorded at six sites at baseline for all
      participants and 3 months after non-surgical periodontal therapy for the study group. GCF
      samples will be collected from the buccal aspects of teeth that had the highest signs of
      inflammation and attachment loss for periodontitis group at baseline and 3 months after
      non-surgical periodontal therapy. As for controls, the samples will be collected from buccal
      aspect of upper first molar at baseline. The samples will be assayed for prolactin by using
      an enzyme linked immunosorbent assay kits (Elisa) according to the manufacturer instruction.
    


Intervention name(s): non-surgical periodontal therapy
Intervention type(s): Procedure
Intervention description(s): scaling and root planing
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: periodontitis; Prolactin; GCF; non-surgical periodontal treatment
Sim (Scratch in Miscarriage) Study
Condition: Recurrent Miscarriage
MeSH terms: Abortion, Spontaneous; Abortion, Habitual
Study type: Interventional

Summary: 
      There is increasing amount of evidence which suggests that miscarriage is related to a
      primary endometrial problem. Recent cochrane meta-analysis (March 2015) has proven that
      endometrial scratch improves live birth in women who underwent IVF.

      The aim of the study is to find out if scratch of the endometrium prevents recurrent
      miscarriage.
    

Detailed description: 
      The Warwick BRU-RH (Biomedical Research Unit- Reproductive Health) hypothesis is that failed
      pregnancies are the result of failed decidualisation of the endometrium.
    

Intervention name(s): Endometrial scratch; Touching the cervix
Intervention type(s): Other; Other
Intervention description(s): If patient randomised to intervention arm, will have speculum examination followed by endometrial scratch with a wallace catheter; If patient is randomised to the control arm, she will have speculum examination followed by cleaning of the cervix with a cotton tip dipped in saline
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Effects of Amino Acid Formulation on Healthy Men Undergoing Unilateral Knee Immobilization
Condition: Muscle Atrophy
MeSH terms: Muscular Atrophy
Study type: Interventional

Summary: 
      This is a safety and tolerability study investigating the effect of an amino acid formulation
      in healthy volunteers during and after limb immobilization.
    


Intervention name(s): Amino Acid; Breg Brace single-leg immobilization; Placebo
Intervention type(s): Dietary Supplement; Device; Other
Intervention description(s): 23.7 g amino acid 3 times daily for 28 days; 7 days of single leg immobilization; randomized to leg; knee brace will be worn in a fixed flexion position at 140°.; Excipient-matched placebo 3 times daily for 28 days
Other intervention name(s): Breg brace
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 2 groups of 10 each will be randomized to receive amino acid supplementation or placebo for 28 days during which they will have one leg immobilized by a removable brace.
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: protein; skeletal muscle; immobilization
A Study Comparing the Efficacy and Safety Between I-CHOP and R-CHOP in Untreated CD20-Positive Diffuse Large B-cell Lymphoma Patients
Condition: Diffuse, Large B-Cell, Lymphoma
MeSH terms: Lymphoma; Lymphoma, Large B-Cell, Diffuse
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to comparing the Efficacy and Safety between I-CHOP and R-CHOP
      in Untreated CD20-Positive Diffuse Large B-cell Lymphoma Patients.
    


Intervention name(s): IBI301 plus CHOP; Rituximab plus CHOP
Intervention type(s): Drug; Drug
Intervention description(s): Six cycles. IBI301: 375 mg/m2, IV, day 1 of each cycle; Cyclophosphamide: 750 mg/m2, IV, day 2 of each cycle; Doxorubicin: 50 mg/m2, IV, day 2 of each cycle; Vindesine: 4 mg, IV, day 2 of each cycle; Prednisone: 100 mg, po, day 2 to day 6 of each cycle.; Six cycles. Rituximab: 375 mg/m2, IV, day 1 of each cycle; Cyclophosphamide: 750 mg/m2, IV, day 2 of each cycle; Doxorubicin: 50 mg/m2, IV, day 2 of each cycle; Vindesine: 4 mg, IV, day 2 of each cycle; Prednisone: 100 mg, po, day 2 to day 6 of each cycle.
Intervention MeSH terms: Rituximab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
The Role of Anti-Reflux Surgery for Gastroesophageal Reflux Disease in Premature Infants With Bronchopulmonary Dysplasia
Condition: Gastroesophageal Reflux Disease; Bronchopulmonary Dysplasia
MeSH terms: Gastroesophageal Reflux; Esophagitis, Peptic; Bronchopulmonary Dysplasia; Hyperplasia
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to evaluate the efficacy of fundoplication in premature infants
      with GERD and BPD.
    

Detailed description: 
      Gastroesophageal reflux disease (GERD) has been postulated to result in chronic aspiration
      contributing to the development of chronic lung disease, otherwise known as bronchopulmonary
      dysplasia (BPD) in premature infants. This association has been indirectly based on anecdotal
      improvement in the respiratory status of infants with BPD after anti-reflux therapy, but the
      direct causal relationship has been difficult to prove. In addition, the historical evidence
      for infants with GERD has been based on acid reflux only which is diagnosed by 24 hour
      intra-esophageal pH monitoring, the gold standard. However, with the introduction of
      multi-channel intraluminal impedance (MII), GERD can now include non-acid reflux. The
      contribution of non-acid reflux to the development of BPD in premature infants is unknown. As
      our understanding of GERD has improved, previous assumptions regarding the efficacy of
      therapy may no longer be valid. The utilization of anti-reflux surgery (fundoplication) for
      the treatment of BPD in premature infants with GERD has not been rigorously studied. The
      efficacy of fundoplication in this patient population has yet to be determined.
    

Intervention name(s): Fundoplication
Intervention type(s): Procedure
Intervention description(s): Fundoplication
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Gastroesophageal Reflux Disease (GERD); Bronchopulmonary Dysplasia (BPD); Fundoplication
Early Versus Late Amniotomy During Labor Induction in Women With Bishop's Score of ≥ 6
Condition: Labor, Induced; Amniotomy
Study type: Interventional

Summary: 
      Labor induction is the stimulation of uterine contractions during pregnancy, before labor
      begins on its own to achieve a vaginal birth.

      A health care provider might recommend labor induction for various reasons: primarily when
      there's concern for a mother's health or a baby's health.

      Combined with oxytocin infusion, amniotomy is commonly used in the induction of labor.
      However the perfect timing of amniotomy is still unknown.

      The aim of this study is to determine whether the early amniotomy followed by oxytocin, or
      initiating induction of labor with oxytocin followed by late amniotomy, is effective to reach
      active phase of labor.
    


Intervention name(s): Amniotomy
Intervention type(s): Procedure
Intervention description(s): artificial rupture of the amniotic sac
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: labor; Amniotomy; induction
Comparison of Hydroxyethyl Starch and Crystalloid Coload Combined With Norepinephrine Infusion for Hypotension
Condition: Adverse Effect
MeSH terms: Hypotension
Study type: Interventional

Summary: 
      The purpose of this study is to investigate the ED50 and ED90 for an effective 6%
      Hydroxyethyl starch (130/0.4) or crystalloid coload combined with prophylactic norepinephrine
      infusion dose for postspinal anesthesia hypotension in patients undergoing cesarean section.
    

Detailed description: 
      Post-spinal anesthesia hypotension is a frequent complication during spinal anesthesia for
      cesarean section. The incidence of post-spinal anesthesia hypotension is as high as
      62.1-89.7% if prophylactic measures are not taken. Colloid fluid coload has been highly
      demonstrated for prevention and/or treatment of post-spinal anesthesia hypotension. In
      addition, there's some evidence that prophylactic infusion of norepinephrine could
      effectively reduce the incidence of post-spinal anesthesia hypotension in parturients
      undergoing cesarean section. However, the ED50 and ED90 for an effective 6% Hydroxyethyl
      starch (130/0.4) or crystalloid coload combined with prophylactic norepinephrine infusion
      dose for postspinal anesthesia hypotension is still unknown. The purpose of this study is to
      investigate the ED50 and ED90 for an effective 6% Hydroxyethyl starch (130/0.4) or
      crystalloid coload combined with prophylactic norepinephrine infusion dose for postspinal
      anesthesia hypotension in patients undergoing cesarean section.
    

Intervention name(s): Hydroxyethyl starch; Crystalloid
Intervention type(s): Drug; Drug
Intervention description(s): 10 ml/kg 6% Hydroxyethyl starch (130/0.4) coload combined with an initial infusion dose of prophylactic norepinephrine (0.025 ug/kg/min) simultaneous with spinal anesthesia. The dose administered to subsequent patients varied by increments or decrements of 0.005 ug/kg/min of prophylactic norepinephrine according to the responses of previous patients according to the up-down sequential allocation.; 10 ml/kg crystalloid coload combined with an initial infusion dose of prophylactic norepinephrine (0.025 ug/kg/min) simultaneous with spinal anesthesia. The dose administered to subsequent patients varied by increments or decrements of 0.005 ug/kg/min of prophylactic norepinephrine according to the responses of previous patients according to the up-down sequential allocation.
Other intervention name(s): Colloid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Crystalloid; Hydroxyethyl starch 130/0.4; Postspinal anesthesia hypotension; Cesarean section; Norepinephrine; Coload
Pilot Testing a New Computer-based Screening Tool to Detect Cognitive Impairment
Condition: Cognitive Impairment
MeSH terms: Cognitive Dysfunction
Study type: Observational

Summary: 
      A computer-based neuropsychological assessment tool is being developed to help primary care
      physicians detect neurological and psychiatric disorders. The first version will be tested
      against current tests to confirm the tool's effectiveness. Data will be collected on how well
      the tool detects disease, how well patients understand the instructions and enjoy performing
      the tasks, and if particular trials or stimuli are too difficult or too easy for all
      subjects. Adjustments can then be made to the assessment tool, if needed. The initial
      participants will be age fifty-five to seventy-five with early dementias or mild cognitive
      impairment to reduce variability.
    

Detailed description: 
      The investigators are developing a computer-based neuropsychological assessment tool to help
      primary care physicians detect neurological and psychiatric disorders. To confirm the tool's
      efficacy, the investigators will first test the prototype against established tests. The
      investigators propose to collect preliminary data on a limited group of subjects and
      age-matched controls. Collecting data on a limited group of subjects provides early insight
      into how well the tool detects disease, how well patients understand the instructions and
      enjoy performing the tasks, and if particular trials or stimuli are too difficult or too easy
      for all subjects. With this information, the investigators can make adjustments to the tool
      if needed and collect additional data on revised versions of the tool. The data will be used
      to establish the validity, reliability and sensitivity of the tool to generate consistent and
      accurate scores. The investigators will initially focus on a limited age range (age
      fifty-five to seventy-five) and limited set of diseases (early dementias or mild cognitive
      impairment) to reduce variability within the patient and control groups and to gain more
      statistical power with a smaller group of subjects.
    

Intervention name(s): cognitive testing
Intervention type(s): Other
Intervention description(s): computer-based cognitive assessment
Observational model: Ecologic or Community
Time perspective: Other
Sampling method: Probability Sample
Study population: 
        Community-dwelling adults without significant cognitive impairment
      
Keywords: neuropsychological assessment; cognitive impairment; computer-aided diagnostic tool
Study to Assess the Tolerability and Efficacy of Anacetrapib (MK-0859) Co-Administered With Statin in Participants With Heterozygous Familial Hypercholesterolemia (MK-0859-020)
Condition: Hyperlipoproteinemia Type II; Hypercholesterolemia, Familial
MeSH terms: Hyperlipoproteinemia Type II; Hypercholesterolemia; Hyperlipoproteinemias; Hyperlipidemias
Study type: Interventional
Phase: Phase 3

Summary: 
      The objective of this study is to evaluate the efficacy and tolerability of adding
      anacetrapib to ongoing statin therapy in participants with heterozygous familial
      hypercholesterolemia (HeFH).
    


Intervention name(s): Anacetrapib; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): One oral tablet, orally once daily for 52 weeks; One oral tablet once daily for 52 weeks
Other intervention name(s): MK-0859
Intervention MeSH terms: Anacetrapib
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
High Intensity Interval Versus Continuous Moderate Intensity Training: Maximizing the Benefits of Exercise in Overweight Adolescents
Condition: Metabolism; Physical Fitness
MeSH terms: Overweight
Study type: Interventional

Summary: 
      6-week, single site, two parallel arm, randomized, controlled trial comparing the
      effectiveness of a High Intensity Interval Training (HIIT) versus a continuous Moderate
      Intensity Training (MIT) program on cardiovascular and metabolic health outcomes in
      overweight adolescent males. HIIT training may be a potent time-efficient strategy to induce
      similar metabolic and cardiovascular adaptations typically associated with MIT.
    


Intervention name(s): High Intensity Interval Training; Moderate Intensity Training
Intervention type(s): Other; Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: high intensity interval training; aerobic exercise; insulin sensitivity; obesity; cardiovascular fitness