Evaluation of Three Strategies Based on Vaginal Self-sampling Kit Send to Home of Unscreened Women for Cervical Cancer
Condition: Cervical Cancer Screening; Cervical Cancer
MeSH terms: Uterine Cervical Neoplasms
Study type: Interventional

Summary: 
      Despite the existence of an effective screening test (pap smear), cervical cancer is, every
      year in France, the cause of more than 3,000 new cases and 1,100 deaths. But, in France, 4 in
      10 women are not screened or not often enough (nearly 7 millions women). It is therefore
      necessary to develop new strategies to reach these women. The etiological factor of this
      cancer is persistent infection with High-Risk Human PapillomaVirus (HR-HPV). Thereby,
      HPV-based tests could be alternative screening tests. Vaginal self-sampling with HR-HPV test
      is simpler and less intrusive than the pap smear. It has been shown that sending vaginal
      self-sampling kit (with HPV test) to unscreened women's home is a powerful means to increase
      the participation rate of cervical cancer screening. It seems interesting to explore methods
      to increase the efficiency of this strategy by optimizing the ratio of the number of kits
      used compared to the number of kits sent. Two approaches will be tested: a system "available
      on request" of the kit and / or the addition of an SMS (Short Message Service) reminder.
    


Intervention name(s): Self-sampling kit sent at home; Self-sampling kit sent at home + SMS reminder; Letter offering a self-sampling kit "on request"+ SMS reminder; SMS offering a self-sampling kit "on request"+ SMS reminder
Intervention type(s): Behavioral; Behavioral; Behavioral; Behavioral
Intervention description(s): Selected women receive a mail inviting them either to perform a vaginal self sampling at their home (with the kit provided) or to perform a pap smear.
When women choose the vaginal self-sampling, a HPV test is performed on the sample in a virology laboratory.; Selected women receive a mail inviting them either to perform a vaginal self sampling at their home (with the kit provided) or to perform a pap smear.
After 2 months without "return", a SMS reminder about the available self-sampling kit is sent to the woman. We call "return" :
the receipt of the vaginal self-sample at the laboratory
the performance of a pap smear
Information about recent screening test or a cervical screening exclusion reason When women choose the vaginal self-sampling, a HPV test is performed on the sample in a virology laboratory.; Selected women receive a mail inviting them either to perform a vaginal self sampling at their home (kit provided on request) or to perform a pap smear.
Women are invited to ask the kit online, on our website.
For the women who ask the kit, after 2 months without "return", a SMS reminder about the available self-sampling kit is sent to the woman. We call "return" :
the receipt of the vaginal self-sample at the laboratory
the performance of a pap smear
Information about recent screening test or a cervical screening exclusion reason When women choose the vaginal self-sampling, a HPV test is performed on the sample in a virology laboratory.; Selected women receive a SMS inviting them to ask a vaginal self sampling kit to perform a sample at home and send it to a laboratory (kit provided on request).
Women are invited to ask the kit by answering "1" by SMS.
For the women who ask the kit, after 2 months without "return", a SMS reminder about the available self-sampling kit is sent to the woman. We call "return" :
the receipt of the vaginal self-sample at the laboratory
the performance of a pap smear
Information about recent screening test or a cervical screening exclusion reason When women choose the vaginal self-sampling, a HPV test is performed on the sample in a virology laboratory.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Screening
Keywords: vaginal; self-sampling; cervical cancer screening; Papillomavirus; HPV; High Risk Human papillomavirus Infection; pap smear