bioihbjkbjnl/mcl2 huggingface dataset:
Bone Healing in Immediate Dental Implants
Condition: Alveolar Bone Loss; Platelet Rich Plasma
MeSH terms: Alveolar Bone Loss
Study type: Interventional

Summary: 
      To study the effect of platelet-rich plasma concentrate on marginal bone loss and bone
      mineral density in immediate implant placement through CBCT.
    

Detailed description: 
      12 subjects were equally categorized into two groups. Group, I was the control group;
      whereas, the subjects in Group II received Platelet Rich Plasma (PRP) therapy. All subjects
      were given a standard treatment with single implant system. Inserted implants were analyzed
      through Cone Beam Computerized Tomography (CBCT). Records were registered at the baseline, at
      12th week before functional loading and 26th week after functional loading.
    

Intervention name(s): PRP injection; Automated blood cell separator to extract PRP
Intervention type(s): Biological; Device
Intervention description(s): PRP was prepared using patient's blood and mixed with saline or mixture of calcium chloride and thrombin to form a liquid solution; in order to inject at the surgical site after placement of implant.; Blood was withdrawn from antecubital vein and mixed with anticoagulant. Blood sample was then centrifuged to obtain platelet rich plasma which was injected at surgical site after implant placement.
Other intervention name(s): Platelet Rich Plasma injection; Automated blood cell separator/ centrifuge
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Dental implant, Cone Beam Computerized Tomography (CBCT).
Treatment Preferences in Patients With Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Observational

Summary: 
      Together with the guidance of health professionals try to obtain information from media,
      popular magazines and books and the internet regarding diseases and treatment methods in
      patients with low back pain with the development of technology. In parallel with this
      information which they obtained, they turn to different treatment methods. This study was
      carried on examining how pain duration affects treatment preferences in patients with low
      back pain.
    


Intervention name(s): Assesment of treatment preference
Intervention type(s): Other
Intervention description(s): Multiple-choice survey questions were created by the researchers based on the studies in the literature regarding the pain and treatment preferences of the participants
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        A total of 155 individuals between the ages of 18-65 with complaints of low back pain,
        meeting the inclusion criteria and agreeing to participate in the study were included in
        the study.
      
Keywords: low back pain; acute pain; subacute pain; chronic pain; treatment preference
Evaluation of Risk Factors for Gestational Diabetes Mellitus
Condition: Diabetes, Gestational; Menstrual Cycle Abnormal
MeSH terms: Diabetes, Gestational; Diabetes Mellitus
Study type: Interventional

Summary: 
      This study examines the relationship between the age at menarche and gestational diabetes
      mellitus (GDM). In this retrospective study, the sample included all pregnant women diagnosed
      with GDM in a pregnancy polyclinic in Kocaeli, Turkey between 2014 and 2019. The sample
      included 373 participants: 233 in the GDM group and 140 in the control group. The groups were
      compared in terms of age at menarche.
    


Intervention name(s): oral glucose loading test
Intervention type(s): Other
Intervention description(s): oral glucose loading test was performed to all participants. gestational diabetes and control group were compared in terms of menarche age.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: menarche; gestational diabetes mellitus; cycle, menstrual
A Pharmacokinetic Study of the Coadministration of LY2216684 With Sertraline
Condition: Major Depressive Disorder
MeSH terms: Depressive Disorder; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 1

Summary: 
      LY2216684 is being studied as adjunctive treatment for major depressive disorder (MDD) in
      participants who are partial responders to selective serotonin reuptake inhibitors (SSRIs).
      Sertraline is a medication that is widely used to treat MDD and is a known substrate of
      cytochrome P450s (CYP450s), including CYP450 2D6 (CYP2D6), CYP450 2C19 (CYP2C19), CYPP450 3A4
      (CYP3A4), and a modest inhibitor of CYP2D6. Based on the diversity of hepatic metabolic
      clearance pathways for LY2216684 and its elimination by the kidney, it is expected that
      CYP2D6 inhibition by sertraline will not result in a substantial change in the
      pharmacokinetic (PK) profile of LY2216684. LY2216684 is only known to be a moderate inhibitor
      of CYP2C19, so it is unlikely that coadministration of sertraline with LY2216684 will result
      in a clinically meaningful change in the PK of sertraline. This study is being conducted to
      test these hypotheses.
    


Intervention name(s): LY2216684; Sertraline
Intervention type(s): Drug; Drug
Intervention description(s): po administration; po administration
Intervention MeSH terms: Sertraline
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Efficacy and Safety of Emodepside in Adolescents and Adults Infected With Hookworm
Condition: Hookworm Infections
MeSH terms: Hookworm Infections; Ancylostomiasis
Study type: Interventional
Phase: Phase 2

Summary: 
      To compare the efficacy and safety of emodepside to that of albendazole (Zentel®) in
      participants aged 12-60, inclusive, infected with hookworm.
    


Intervention name(s): Emodepside; Albendazole 400mg
Intervention type(s): Drug; Drug
Intervention description(s): Treatment with Emodepside 30 mg; Treatment with Albendazole 400 mg
Intervention MeSH terms: Albendazole; Emodepside
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Hookworm; Emodepside; Efficacy; Safety; Confirmatory Stage; Soil Transmitted Helminth
Educational Video for Improving Follow-up After an Emergency Department Visit for Asthma
Condition: Asthma
MeSH terms: Asthma; Emergencies
Study type: Interventional

Summary: 
      The study will assess the efficacy of a three-part Emergency Department (ED)-based "Asthma
      Belief and Control" intervention on healthcare utilization, asthma controller medication use,
      symptoms, and quality of life during the 6 months following an Emergency Department visit.
    

Detailed description: 
      Inner-city children are particularly at risk for poor asthma treatment outcomes and
      frequently obtain their asthma care in the ED. Prior studies have had limited success in
      improving primary care follow-up, quality of care, and long-term outcomes after a pediatric
      ED visit for asthma. Prior ED-based interventions have been designed to address barriers to
      follow-up with a primary care provider (PCP) such as an inability to obtain a follow-up
      appointment or lack of transportation. Focus groups and surveys of inner-city families have
      found that beliefs about the benefits of follow-up care and the role of preventive asthma
      medications have a strong impact on adherence to therapy.

      This study will develop a brief educational video about the benefits of follow-up asthma care
      using a multi-disciplinary panel of experts at the Children's Hospital of Philadelphia and
      focus groups of parents of children with asthma. This educational video will then be combined
      into an intervention along with symptom screening and a reminder phone call that has been
      demonstrated to improve follow-up rates in a previous study. The combined intervention will
      be tested using a randomized trial design to determine its efficacy on healthcare
      utilization, asthma controller medication use, symptoms, and quality of life during the 6
      months following an ED visit. The research is conducted as part of a research career
      development award.
    

Intervention name(s): Intervention Subjects
Intervention type(s): Behavioral
Intervention description(s): The subject's family will view a brief educational video about asthma control and therapy developed using provider and patient focus groups; a mailed reminder will be sent to the family to schedule a follow-up appointment.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Asthma; Emergency; Primary Care; Children
Sleep Duration in Women With Previous Gestational Diabetes
Condition: Gestational Diabetes
MeSH terms: Diabetes, Gestational; Diabetes Mellitus
Study type: Interventional

Summary: 
      Women with a history of gestational diabetes (GDM) are at high risk of developing diabetes in
      the future. Sleep disturbances are emerging as risk factors for incident diabetes. The
      purpose of this study is to test the effects of 6-week sleep extension in women with a
      history of GDM and short sleep on glucose metabolism by randomized controlled study.
    

Detailed description: 
      The primary aim of this study is to evaluate the effects of a sleep extension intervention in
      non-diabetic women with a prior history of GDM and habitual short sleep duration on the
      outcomes of glucose metabolism. The participants will be randomized to a 6-week sleep
      extension intervention group, using technology-assisted sleep intervention, or a healthy
      living information control group. Glucose metabolism parameters will be assessed by an oral
      glucose tolerant test.
    

Intervention name(s): Sleep extension; Healthy living
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Sleep extension aims to increase sleep duration for at least 30 minutes using weekly coaching; Participants will receive weekly health education
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: sleep duration; glucose metabolism
Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD)
Condition: COPD; Emphysema; Chronic Bronchitis
MeSH terms: Bronchitis; Bronchitis, Chronic; Emphysema
Study type: Observational

Summary: 
      The aim of this study is to investigate the mechanisms whereby leukocytes are recruited to
      the lung in chronic obstructive pulmonary disease (COPD) and cause tissue destruction. The
      hypothesis is that in COPD more leukocytes enter the lung and it is these cells that are
      responsible for the degradation of lung tissue. We, the researchers at Imperial College
      London, will isolate leukocytes from the blood of patients with COPD, healthy smokers and
      normal subjects and measure the movement of the leukocytes to chemoattractants. We will
      examine further, which cell surface receptors are responsible for this trafficking of cells.
      Furthermore, the differentiation of these cells in vitro will be compared with cells from
      healthy smokers and normal subjects. Specifically, the expression of enzymes that are
      responsible for tissue destruction and the cell surface receptors on these cells will be
      investigated. The objective is to identify the mechanisms whereby leukocytes from COPD
      patients behave differently to cells from healthy smokers and normal subjects with a view to
      identify novel targets for drug therapy.
    

Detailed description: 
      Chemotaxis experiments will be performed in order to ascertain the migratory characteristics
      of leukocytes towards specific chemoattractants. Comparisons of cells from different subjects
      will be compared. In addition, the effects of various pharmaceutical interventions on this
      mechanism will also be addressed and compared within subject groups. In some experiments,
      cells will be differentiated in vitro and their cellular expression and regulation of
      inflammatory mediators and chemoattractants examined. Again comparisons will be made between
      subject groups and the efficacy of various pharmacological agents on these cells
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients who had taken inhaled or oral steroids or who had suffered an exacerbation of
        their airway disease in the previous 6 weeks were excluded.
      
Biospecimen description: 
      Blood
    
Keywords: chemokine; chemokine receptor; neutrophil; lymphocyte; monocyte
The Use of an Online Learning and Consent Platform in Infertility Treatment
Condition: Patient Satisfaction
Study type: Interventional

Summary: 
      The primary purpose of this study is to objectively assess if interactive multimedia
      tutorials (online videos) enhances patients' comprehensive understanding of assisted
      reproductive technology (ART) adding EngagedMD, an online library of interactive videos,
      compared to the traditional process of consent and one-on-one teaching using a 15 question
      evaluation. The secondary outcome will be to qualitatively assess patients' overall
      experience of the teaching process comparing the addition of the EngagedMD content to solely
      traditional teaching for infertility treatment.
    

Detailed description: 
      Participants: This will be a multi-center trial with each center planning on recruiting 100
      couples. Half of the couples will be planning on undergoing ovulation induction with
      insemination (OI/IUI) and the other half in-vitro fertilization (IVF).

      Procedures (methods): This is a multi-center prospective randomized controlled trial where
      couples undergoing OI/IUI or IVF will be randomized to receiving the current traditional
      standard of in-person treatment teaching by their physician and nursing team with standard
      paper consents or to the identical process of in-person teaching with the addition of
      unrestricted access to the EngagedMD online video resource platform with online consents.

      Patient demographics, knowledge base, psychological impact of with the treatment, teaching
      and the consent process and overall satisfaction with the process as a whole will be assessed
      using surveys administered at three time points throughout the treatment process. A subset of
      patients that agree will be contacted after the completion of the treatment cycle for a live
      phone interview.
    

Intervention name(s): EngagedMD online learning platform
Intervention type(s): Other
Intervention description(s): The EngagedMD online learning platform is a compilation of learning modules and questions designed to give patients at-home access to visual and audio aids in infertility treatment. It also gives patients the ability to read and sign consents from home.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized controlled trial comparing one group receiving standard care and the other with standard care with the addition of the online learning platform
Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Patient education
Basiliximab in Moderate to Severe Ulcerative Colitis
Condition: Ulcerative Colitis
MeSH terms: Colitis; Colitis, Ulcerative; Ulcer
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to assess the safety, effectiveness and pharmacokinetics of two
      levels of intravenous basiliximab in ulcerative colitis, compared to placebo.
    


Intervention name(s): Basiliximab
Intervention type(s): Drug
Intervention description(s): 3 doses of 40mg, IV at baseline, week 2, and week 4
Other intervention name(s): Simulect
Intervention MeSH terms: Basiliximab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: ulcerative colitis basiliximab
The Role of Protein Tyrosine Kinase 7 (PTK7) in Non-small Cell Lung Cancer
Condition: Tumor Progression
MeSH terms: Lung Neoplasms; Carcinoma, Non-Small-Cell Lung
Study type: Observational

Summary: 
      To understand the mechanism and cellular functions of PTK7-associated signaling pathways in
      promoting lung cancer progression and conferring treatment to epidermal growth factor
      receptor tysosine kinase inhibitors (EGFR TKIs).
    

Detailed description: 
      -  RNA extraction: We will extract total RNA from cell lysates by using Tri-reagent
           (Molecular Research Center, Inc., Cincinnati, Ohio) and an RNA Mini Kit (Qiagen, Hilden,
           Germany) according to the manufacturer's instruction. RNA obtained from the Mini Kit
           column will be eluted. The quantity and quality of the purified RNA will be evaluated
           using a NanoDrop ND-1000 spectrophotometer will be stored at -80 °C for further
           mutational analyses.

        -  Data acquisition: We will record and follow patients' clinical information, including
           ethnicity, age, gender, smoking status, histological types, lung cancer stage (the TNM
           status), metastatic sites, ECOG score, CT/CXR imaging, chemotherapy or radiation
           treatment at the time of diagnosis of lung cancer and through the entire clinical
           courses. Specific marker such as TTF1, is used to ensure the diagnosis of primary lung
           tumor. Clinicopathologic stage assigns according to the seventh tumor-node-metastasis
           classification. We assess the treatment responses according to the Response Evaluation
           Criteria in Solid Tumors (RECIST) using the unidimension method, and record the best
           response achieved per treatment. Treatment response, progression-free survival, and
           overall survival are recorded prospectively for further analysis.

        -  Statistical analysis: All categorical variables will be analyzed with Pearson's χ² test,
           except where a small size required the use of Fisher's exact test. The progression-free
           survival curve and overall survival will be plotted by the Kaplan-Meier method and
           compared by the log-rank test. Multivariate analysis for overall survival will be
           performed using the Cox's proportional hazards model. Two-sided p-values of less than
           0.05 is considered significant. All analyses will be performed using SPSS software
           (version 16.0 for Windows; SPSS Inc.).
    

Observational model: Case-Only
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        only citizens of Taiwan will be enrolled.
      
Biospecimen description: 
      Biopsy tissue, DNA, RNA
    
Keywords: non-small cell lung cancer; epidermal growth factor receptor tyrosine inhibitor
Clinical Trial of CT1812 in Mild to Moderate Alzheimer's Disease
Condition: Alzheimer's Disease
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This is a multi-center, randomized, double-blind, placebo-controlled, parallel group study of
      two doses of CT1812 in adults with mild to moderate Alzheimer's Disease to evaluate the
      safety and tolerability of oral CT1812, administered for 28 days. This trial may include up
      to 8 qualified investigator sites in Australia.
    

Detailed description: 
      Screening procedures will occur up to 42 days. Eligible subjects will randomized at the
      clinic on Day 1 and receive the first dose of study drug. Dosing for 28 days thereafter
      off-site and a total of 5 clinic visits over the treatment period for safety and lab
      assessments. Then a 7 day post-treatment completion follow-up visit (Day 35) and End of Study
      for last safety assessments (Day 49).
    

Intervention name(s): CT1812; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Active study drug; non-active study drug
Other intervention name(s): Study Drug; Matching placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Internet-Based Cervical Cytology Screening Program
Condition: Cervical Cancer
MeSH terms: Uterine Cervical Neoplasms
Study type: Observational

Summary: 
      The purpose of this study is to assess whether a system that couples automated screening of
      Pap Tests with transmission of machine selected digital images, and review by cytologists at
      a remote location, performs to a clinically effective standard of accuracy.
    

Detailed description: 
      This clinical study uses the automated screening capabilities of the FocalPoint Primary
      Screening System (BD) for gynecologic cytology specimens (Pap tests) to allow for automated
      field of view (FOV) selection, digital image capture, and subsequent Internet-based
      transmission to a custom designed computer-based image reading station. The system utilizes
      liquid-based cytology preparations (ThinPrep, SurePath). In such a system, no skilled
      cytology human resources are necessary at the scanning site, and all expertise can be
      centralized. Pilot studies showed that the task was feasible to a clinically relevant
      standard of care. Phase 1 trials on preselected and seeded specimens confirmed this clinical
      standard. The phase 2 trials extend the concept to a prospectively enrolled population of
      patients from 2 sites (Walter Reed, Mass General) thereby testing the concept in a population
      of normal disease prevalence. The final phase 3 will be a larger study with intended use
      design, siting a screening device at the 121st Army Hospital in Korea and interpreting the
      specimen images in the US. In addition to the reading of the specimens, the system is
      designed to give immediate "loop closing" results back to each specimen's originating point
      immediate upon completion of the test.
    

Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Females presenting to clinics at MGH or WRAMC for a Pap test
      
Keywords: Cervical cancer, automation, Internet, telecytology
Glycine vs Placebo for the Schizophrenia Prodrome
Condition: Schizophrenia Prodrome
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      Glycine is a natural amino acid neurotransmitter that acts as a co-agonist at NMDA receptors
      in brain. We hypothesize that symptoms of the schizophrenia prodrome will improve with
      glycine to a greater degree than with placebo.
    

Detailed description: 
      A pilot clinical trial comparing glycine to placebo in patients with the schizophrenia
      prodrome.
    

Intervention name(s): Glycine; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Glycine 0.4 g/kg bid; Placebo
Intervention MeSH terms: Glycine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: schizophrenia prodrome