bioihbjkbjnl/mcl2 huggingface dataset:
Fox Investigation for New Discovery of Biomarkers
Condition: Parkinson's Disease
MeSH terms: Parkinson Disease
Study type: Observational

Summary: 
      This is an observational, multi-center study to assess clinical features and biologic
      biomarkers in Parkinson's disease (PD) patients compared to healthy controls (HC). The
      primary objective of this study is to discover clinical and biologic markers of PD for use in
      clinical trials of disease-modifying therapies.
    

Detailed description: 
      BioFIND is a two-year observational clinical study designed to discover and verify biomarkers
      of Parkinson's disease (PD). BioFIND is collecting clinical data and biospecimens, including
      blood and cerebrospinal fluid (CSF), in a population of 120 well-defined, moderately advanced
      PD subjects and 120 healthy controls.

      BioFIND will follow standardized data acquisition protocols to ensure that tests and
      assessments conducted at multiple sites can be pooled. Data and samples acquired from study
      participants will enable the development of a comprehensive Parkinson's database and
      biorepository, which will be available to the scientific community to conduct research on
      novel PD biomarkers.
    

Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Parkinson's disease and healthy control subjects
      
Biospecimen description: 
      Cerebrospinal Fluid (CSF), whole blood, DNA, plasma
    
Keywords: Parkinson's; Biomarkers; Neurodegenerative disorder
Color and Pupil Function
Condition: Pupil
Study type: Interventional

Summary: 
      This study will examine the effects of different colors of light on pupil function and
      alertness.
    


Intervention name(s): Light
Intervention type(s): Other
Intervention description(s): A brief, 1 minute exposure to light of varying color and intensity. The combination of color and intensity will be the same in all participants, but the order in which they are received is randomized.
Intervention model: Single Group Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
Continuous Blockade of the Brachial Plexus
Condition: Arthroses; Degenerative Disorder; Osteoarthritis
MeSH terms: Osteoarthritis
Study type: Observational

Summary: 
      This study will answer the question whether there is a difference in the effects and
      complication rates of ultrasound guided continuous interscalene block (CISB) and nerve
      stimulation-guided continuous cervical paravertebral block (CCPVB). The aim of this study is
      to evaluate the differences in efficacy and side effects - if any.
    

Detailed description: 
      This is a prospective randomized double-blinded study that will compare two commonly used
      approaches for the continuous blockade of the brachial plexus: the CCPVB, which focusses on
      the six cervical nerve root (C6 root), and CISB, which focuses on the upper trunk of the
      brachial plexus. Data of sensory testing, motor strength, shoulder pain, phrenic nerve
      function, recurrent laryngeal nerve (RNL) function, ipsilateral Horner's syndrome, block time
      and medication doses used for block placement, will be collected. All observations and
      measurements will be made by a member of the research team who is unaware of patient
      allocation to any particular group.
    

Intervention name(s): Ultrasound-guided CISB; nerve stimulator-guided CCPVB
Intervention type(s): Device; Device
Intervention description(s): This group will receive ultrasound-guided CISB with the catheter placed on the upper trunk of the brachial plexus; This group will receive landmark with nerve stimulator based needle placement and then nerve stimulator-guided CCPVB with the catheter placed on the 6th cervical spinal root
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients who are are scheduled for shoulder arthroplasty or rotator cuff repair surgery at
        an area hospital
Down-titration of Steroids in Patients With Difficult Asthma With no Bronchial Hyperreactivity
Condition: Asthma
MeSH terms: Asthma; Bronchial Hyperreactivity
Study type: Interventional

Summary: 
      An 8 week 'real-life' inhaled corticosteroid (ICS) dose reduction study in patients with
      severe asthma without evidence of bronchial hyperactivity.
    

Detailed description: 
      We aim to describe the proportion of patients with severe asthma, but without objective
      evidence of active disease, who can successfully be reduced in ICS dose for a period of 8
      weeks. This is also intended as an exploration of the methodology and feasibility of
      step-down studies with this patient group, to act as a pilot for future projects.

      This study enrolled patients from the SATS severe asthma study, in which they had undergone
      systematic investigation for comorbidities, triggers and barriers to good asthma control.

      After baseline investigations, the patient's ICS dose is halved (or as close as possible to,
      but not below, 50%). Patients continued on the same inhaled steroid drug and device. Patients
      taking a combined ICS/LABA inhaler halve the dose of this, as per usual clinical practice.
      Other asthma medicaitons are continued unchanged.
    

Intervention name(s): Change to dose of patient's regular medication
Intervention type(s): Drug
Intervention description(s): Dose reduction of the drug each patient was already taking
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Serum and Peritoneal CEA and CA 19-9 for Gastric Adenocarcinoma
Condition: Gastric Adenocarcinoma
MeSH terms: Adenocarcinoma
Study type: Observational

Summary: 
      For preoperative staging and prediction of peritoneal dissemination of gastric
      adenocarcinoma, usage of serum and peritoneal levels of carcinoembryonic antigen (CEA) and CA
      19-9 may be helpful. Additionally, the prognosis of the patients with gastric adenocarcinoma
      treated with gastrectrectomy may be associated with serum and peritoneal levels of tumor
      markers.
    

Detailed description: 
      Clinical usage of tumor markers on preoperative staging and prediction of peritoneal
      dissemination of gastric adenocarcinoma is a controversial issue. It has been thought that
      there is a positive correlation between serum and peritoneal levels of carcinoembryonic
      antigen (CEA) and CA 19-9 and pathologic features of gastric tumors and peritoneal
      dissemination.

      In this study, it was aimed to evaluate the effect of serum and peritoneal CEA and CA 19-9 to
      predict TNM stages and peritoneal washing cytology in patients with gastric adenocarcinoma
      after curative gastrectomy, and to determine predictive value of these measurements to the
      development of recurrence and death.
    

Intervention name(s): gastrectomy; sampling of peritoneal washing aspirate
Intervention type(s): Procedure; Procedure
Intervention description(s): radical total/subtotal gastrectomy with D2 lymph node dissection; After thoroughly examination of the peritoneal cavity revealing the absence of peritoneal dissemination, the peritoneal cavity was washed with 200 ml of saline, and at least one third was aspirated from several regions of the peritoneal cavity, including near the primary tumor, the left and right subphrenic areas and the pouch of Douglas with suction tubes to a clean bottle and designated as the peritoneal sample for determination of peritoneal levels of CEA and CA 19-9.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        gastric adenocarcinoma treated with curative gastrectomy
      
Keywords: gastric adenocarcinoma; tumor markers; peritoneal cytology
Clinical Validation of Embryo Cinematography
Condition: Embryo Diagnosis and Selection
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether the multivariable model for embryo
      selection (Meseguer et al. 2012) together with undisturbed controlled conditions obtained by
      a time-lapse incubator system is effective in improving ongoing pregnancy rate in comparison
      with standard incubator and an embryo selection process based exclusively in morphology.
    


Intervention name(s): Observe embryo development with "Unisense FertiliTech A/S" (EC Certificte DGM - 673); Observe embryo development
Intervention type(s): Device; Device
Intervention description(s): Observation of exact timing of embryo cleavages together with other morphology dynamics parameters.; Observe embryo development in the traditional manner
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Diagnostic
EPO906 Therapy in Patients With Prostate Cancer
Condition: Prostatic Neoplasms
MeSH terms: Prostatic Neoplasms
Study type: Interventional
Phase: Phase 2

Summary: 
      This study will examine whether the new investigational drug EPO906, given by intravenous
      infusion (IV directly into the vein), is effective in shrinking tumors and preventing the
      growth of cells that cause prostate cancer.
    


Intervention name(s): epothilone b
Intervention type(s): Drug
Intervention MeSH terms: Epothilones; Epothilone B
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: prostate cancer; prostate; androgen independent; cancer; tumor; tumour; neoplasm; carcinoma; intravenous; epothilone
E-nose and Inflammatory Asthma Phenotypes
Condition: Persistent Asthma
MeSH terms: Asthma
Study type: Interventional

Summary: 
      Patients with persistent asthma have different inflammatory phenotypes. The electronic nose
      is a new technology capable of distinguishing volatile organic compound breath-prints in
      exhaled breath among different pulmonary diseases.

      Question of the study. Is the electronic nose breath-print analysis able to discriminate
      among different inflammatory asthma phenotypes?
    

Detailed description: 
      Materials/patients and methods. Fifty-two consecutively enrolled patients with persistent
      asthma were included in a cross-sectional proof of concept study. Inflammatory asthma
      phenotypes were recognized by inflammatory cell counts in induced sputum. Breath-prints were
      analyzed by discriminant analysis on principal component reduction, resulting in
      cross-validated accuracy values. Receiver Operating Characteristics (ROC) was calculated.

      Legal and ethical aspects The study was conducted in accordance with the Declaration of
      Helsinki principles (18th Word Medical Assembly, 1964) and was approved by the Clinical
      Research Ethics Committee (approval number: IIBSP/10/122/1161) of our institution. The
      participants provided their written informed consent to participate in this study and
      personal identification data were anonymized.
    

Intervention name(s): electronic nose
Intervention type(s): Other
Intervention description(s): Exhaled gas to assess e-nose VOC profiles was collected as described. Briefly, patients breathed through a mouthpiece into a 2-way nonrebreathing valve (Hans rudolph 2700, Hans rudolph, Kansas City, Mo) with an inspiratory VOC filter and an expiratory silica reservoir to dry the expired air. Expiratory air was collected in a 10-L "Tedlar bag". Within not more than 10 minutes, the bag was connected to the e-nose device (Cyranose 320®; Smith Detections, Pasadena, CA), provided with a 32 organic polymeric nano-composite sensor array, for 5 minutes and changes in the nano-sensor electrical resistance generated a breath-print VOC profile.
Other intervention name(s): Cyranose 320®; Smith Detections, Pasadena, CA
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Screening
Keywords: asthma; inflammation; electronic nose
Arthrocentesis and Temporomandibular Joint Disorders a Conservative Alternative to Surgical Treatments
Condition: TMJ Internal Derangement
Study type: Observational

Summary: 
      This study aims to evaluate the efficacy of arthrocentesis in the treatment of internal
      derangement of the temporomandibular joint (TMJ).
    

Detailed description: 
      This work was designed as a prospective case series clinical study. Patients imaging was
      evaluated with Cone-Beam Computed Tomography and Nuclear Magnetic Resonance at the beginning
      of the treatment and after the last arthrocentesis.
    

Intervention name(s): TMJ arthrocentesis
Intervention type(s): Procedure
Intervention description(s): lavage of the superior TMJ space with saline and sodium hyaluronate (SH)
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        A total of 30 patients with TMJ internal derangement and pain with history of failed
        conservative management were selected. 70% had anteriorly displaced discs (AD), and 30
        complained of other disorders (osteophytes, signs of soft tissues inflammmation, TMJ
        structure alterations).
      
Keywords: TMJ arthrocentesis; internal derangement; conservative treatment
A Trial To Assess The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of Single Doses Of PF-04937319 In Subjects With Type 2 Diabetes Mellitus
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to characterize the safety, tolerability, pharmacokinetics, and
      pharmacodynamics of PF-04937319 following single escalating oral doses in adult subjects with
      Type 2 Diabetes Mellitus (T2DM).
    

Detailed description: 
      The purpose of this phase 1 study is to characterize the safety, tolerability,
      pharmacokinetics, and pharmacodynamics of PF04937319 following single escalating oral doses
      in adult subjects with T2DM.
    

Intervention name(s): Placebo; PF-04937319
Intervention type(s): Drug; Drug
Intervention description(s): Placebo to match PF-04937319 will be provided.; The initial planned dosing schedule is: 10, 30, 100, 200, and 400 mg, with one cohort to be determined. Doses shown may be adjusted upwards or downwards and may be adjusted to include intermediate doses. All doses will be administered as a single oral dose as a powder-in-capsule (PIC) formulation. PF-04937319 will be supplied as 10 mg and 80 mg (and potentially 1 mg) PIC.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Other
Keywords: phase 1; safety and tolerability; PK; PD; type 2 diabetes mellitus; T2DM
Trial of the Efficacy of Intravenous Immunoglobulin for Treating Women With Unexplained Secondary Recurrent Miscarriage
Condition: Secondary Recurrent Miscarriage
MeSH terms: Neoplasm Metastasis; Abortion, Spontaneous; Abortion, Habitual; Recurrence
Study type: Interventional
Phase: Phase 3

Summary: 
      The investigators want to test whether infusions of intravenous immunoglobulin - a blood
      product known to modify immune responses - in early pregnancy will increase the chance of a
      subsequent live birth in women with three or more miscarriages after a birth and a total of
      at least four miscarriages. This will be done in a trial where 82 patients will be randomly
      allocated to infusions with intravenous immunoglobulin or placebo during pregnancy.
    


Intervention name(s): Intravenous immunoglobulin; Human albumin
Intervention type(s): Drug; Drug
Intervention description(s): Intravenous infusions, 25-35 g each time, 4th to 15th gestational week; Repeated infusions of Human Albumin 5%, 250-350 ml between 4th and 15th gestational week
Other intervention name(s): Intravenous immunoglobulin Privigen CSL Behring 100mg/ml; Human Albumin 5% CSL Behring
Intervention MeSH terms: Immunoglobulins; Immunoglobulins, Intravenous; Antibodies; gamma-Globulins; Rho(D) Immune Globulin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: recurrent miscarriage; immunology; intravenous immunoglobulin; miscarriage
The Interaction Between Appetite Hormones
Condition: Obesity
Study type: Interventional

Summary: 
      Glucagon Like Peptide (GLP) -1 affects metabolic response corrected for weight change
    

Detailed description: 
      Many obese people have had several successful weight losses, however very few can maintain
      the weight loss over a longer period (e.g. one year) Therefore, we want to investigate the
      metabolic response and the importance for maintenance of weight loss in obese people, who
      lost at least 7, 5 % body weight by low calorie diet followed by 52 weeks of diet weight
      maintenance with or without supplement of GLP-1.
    

Intervention name(s): GLP-1; low calorie diet
Intervention type(s): Other; Dietary Supplement
Intervention description(s): GLP-1; low calorie diet
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Basic Science
Dynamic Plantar Pressures Changes After Dry Needling in Flexor Digitorum Brevis Versus Non Emission Laser
Condition: Flatfoot
MeSH terms: Flatfoot
Study type: Interventional

Summary: 
      Thirty-six subjects randomly distributed between a dry needling intervention group and a
      control group whose intervention is a non-emission laser. All the subjects will be measured
      before and after the interventions of each group. The measurements will be made on a pressure
      platform to record the dynamic footprint variables.
    

Detailed description: 
      Thirty-six subjects randomly distributed between a dry needling intervention group and a
      control group whose intervention is a non-emission laser. All the subjects will be measured
      before and after the interventions of each group. The measurements will be made on a pressure
      platform to record the dynamic footprint variables of the first step of both feet.
    

Intervention name(s): Bilateral dry needling in latent trigger points of the Flexor digitorum Brevis Muscle; Bilateral non emission Laser in latent trigger points of the Flexor digitorum Brevis Muscle
Intervention type(s): Other; Other
Intervention description(s): Bilateral dry needling in latent trigger points of the Flexor digitorum Brevis Muscle in flatfoot; Bilateral non emission Laser in latent trigger points of the Flexor digitorum Brevis Muscle in flatfoot
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Foot; gait; Dry Needling; trigger point
Influenza Vaccination in Bone Marrow Transplantation
Condition: Influenza
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to determine whether influenza vaccination protects patients who
      receive a certain type of bone marrow transplantation.
    

Detailed description: 
      Patients who receive bone marrow transplantation are at high risk for complications from
      influenza infection. It is not whether influenza vaccination protects patients who undergo a
      type of bone marrow transplantation called "nonmyeloablative", or "reduced intensity" bone
      marrow transplantation. This study compares the response to influenza vaccination in a group
      of these patients to that in healthy people.
    

Intervention name(s): inactivated split-virus influenza vaccine
Intervention type(s): Biological
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Peripheral blood stem cell transplantation; Non-myeloabalative; Influenza vaccination; Humoral immune response; Immunogenicity
Preferences About Personal Protective Equipment
Condition: Dental Anxiety; Behavior, Child; Preference, Patient
Study type: Observational

Summary: 
      Personal protective equipment (PPE) gained importance during the Coronavirus Disease 2019
      (COVID-19) pandemic, which is a global hot topic for all healthcare staff.
    

Detailed description: 
      To assess children and parents preferences about dentists' appearance concerning their PPE
      and to determine the relationship between the preferences of the children and their parents.

      A total of 250 children aged with 6-12 years and their parents were enrolled in the study.
      Standardised pictures with different sex, attire, eye protector, hair protector, mask and
      gloves were shown to children and their parents separately and asked to chose their
      preferences. Dental anxiety of children and their parents were determined with MCDASf and
      MDAS, respectively. Decayed-missing-filled teeth (DMFT) index was employed to the children.
    

Intervention name(s): Dental anxiety scales
Intervention type(s): Behavioral
Intervention description(s): The Faces Version of Modified Child Dental Anxiety Scale (MCDASf), which is a psychometric dental anxiety scale for children with eight questions, was used to determine the dental anxiety levels of the children. The scores of each question are represented by varying cartoon faces according to emotions ranging from 1 'relaxed' to 5 'very anxious'. The total scores range from 8 to 40. The scores were categorized as not anxious (>9), slightly anxious (9-16), fairly anxious (17-24), very anxious (25-32), and extremely anxious (33-40).
the Modified Dental Anxiety Scale (MDAS) was administered to parents, differently from children. The MDAS has five questions. The scores of each question range from 1 'relaxed' to 5 'very anxious.' The total score ranges from 5 to 25.
Observational model: Case-Crossover
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        children who presented for the first time to the Faculty of Dentistry in Rize and their
        parents
      
Keywords: Personal protective equipment; dental anxiety; parents; preferences; health care professionals