Acute Effects of Organic Guayusa Extract
Condition: Acute Physiological Effects of Organic Guayusa Extract
Study type: Interventional

Summary: 
      Guayusa extract is a caffeinated tea leaf unique blend of antioxidants and caffeine. It is
      marketed as an ingredient that can help support energy and performance with potential
      health-related benefits. It has also been indicated as being as safe as any other existing
      teas (i.e., green tea). However, no studies have previous studied the dose-response effects
      of guayusa extract for supporting cognitive function, mood, metabolism, nor its effects on
      resting heart rate, blood pressure, and electrocardiogram characteristics.
    

Detailed description: 
      Guayusa extract is a caffeinated Amazonian 'super-leaf' belonging to the holly species that
      contains a unique blend of polyphenol antioxidants and caffeine (~20% caffeine, 30%
      chlorogenic acids, 5% catechins). It is also remarkably low in tannins which are responsible
      for the bitter taste found in most teas - giving it a sweet flavor profile. As such, it is
      marketed as an ingredient that can help support energy and performance (e.g., via caffeine
      content) with potential health-related benefits due to its antioxidant properties. Indeed,
      ingredients such as these are often consumed by individuals prior to exercise in order to
      help improve neurocognitive performance, mood, or otherwise to support health-related goals
      such as metabolism. Whereas several studies have suggested that caffeine and chlorogenic acid
      consumption may improve performance, mood, and concentration, and some evidence in animals
      have linked catechin consumption to improved health outcomes, no studies have previous
      studied whether guayusa extract supplementation helps to support these, nor has the
      dose-effectiveness been tested, in humans.

      In this study, the effects of acute dietary supplementation with two different doses of
      botanical organic guayusa extract on neurocognitive/motor-cognitive performance, mood, focus,
      and jitteriness, resting metabolism, and resting heart rate, blood pressure, and
      electrocardiogram characteristics will be examined.
    

Intervention name(s): Acute Moderate-Dose Guayusa Extract Supplementation; Acute High-Dose Guayusa Extract Supplementation; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Participants will consume two vegan capsules with one capsule containing 600 mg AmaTea® and 1 containing 600 mg dextrose.; Participants will consume two vegan capsules with each capsule containing 600 mg AmaTea® (1200 mg total).; Participants will consume two vegan capsules with each capsule containing 600 mg dextrose (1200 mg total).
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Randomized, placebo-controlled, double-blind, crossover study
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
Keywords: dietary supplementation; cognitive performance; metabolism; heart rate; blood pressure; electrocardiogram; mood