bioihbjkbjnl/mcl2 huggingface dataset:
The Effect of Diet and Exercise in Heart Failure
Condition: Heart Failure, Congestive; Metabolic Syndrome X; Obesity
MeSH terms: Heart Failure; Microvascular Angina; Metabolic Syndrome
Study type: Interventional

Summary: 
      A growing number of people in this country are overweight or obese. This is concerning as
      increasing weight has been shown to increase the risk of developing heart failure. However,
      there is also research to suggest that in people who already have heart failure, heavier
      people live longer. So, how does being overweight put a person at risk for heart failure, but
      once they have heart failure, protect them? There is no clear explanation for this dilemma.

      People who are obese commonly have other diseases, such as high blood pressure, high
      cholesterol, and diabetes, that increase the risk of developing heart disease. It is this
      group of diseases that is referred to as "The Metabolic Syndrome." People with the metabolic
      syndrome also have increased levels of inflammation and clotting proteins in their blood
      stream. Current treatment of the metabolic syndrome involves using medications for
      cholesterol, blood pressure, and diabetes. Diet and exercise are also commonly recommended.

      "Lifestyle intervention programs" are programs that help people lose weight by changing their
      eating habits and exercise / activity routines. Weight loss and exercise have been shown to
      lower the risk of developing diabetes and improve diabetes control, improve cholesterol
      abnormalities, and lower blood pressure. These programs have not previously included heart
      failure patients, however.

      We hypothesize that using a lifestyle intervention program in addition to the usual
      medications for heart failure will result in improved symptoms of heart failure and control
      of the metabolic syndrome.

      This study will be the first research study to look at the use of diet and exercise in
      treating heart failure patients who are overweight / obese with "the metabolic syndrome." The
      study will last 6 months. From this study we hope to learn whether diet and exercise is
      helpful in treating heart failure patients who are overweight. Specifically, the study will
      look at the short term effects on cardiac risk factors (blood pressure, cholesterol, blood
      sugar), heart failure symptoms, and exercise capacity.
    


Intervention name(s): Lifestyle Modification (diet, exercise, and behavior)
Intervention type(s): Behavioral
Intervention description(s): Patients recieve weekly sessions with dietician, replace 2 meals/day with meal replacement beverage, and initiate a walking program.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Heart failure, congestive; Metabolic Syndrome X; Obesity
Macintosh and D-Blade® in Simulated Difficult Airway
Condition: Difficult Intubation; Cervical Injury Spine
MeSH terms: Spinal Injuries
Study type: Interventional

Summary: 
      In the presented study, our aim was to compare intubation conditions regarding the modified
      Cormack & Lehane score (CL) between the D-Blade® in indirect laryngoscopy or Macintosh blade
      in direct and indirect laryngoscopy with C-MAC PM® in a simulated setting of a difficult
      airway in human subjects.
    

Detailed description: 
      Patients with unexpected difficult airway requiring endotracheal intubation (ETI) remain
      extremely challenging for emergency physicians and intubation failure with subsequent hypoxic
      complications still represents the majority of cases in a recent closed claims analysis.

      An incidence of major complications in airway management of 1 in 5,500 was estimated in the
      Fourth National Audit Project in the UK.

      Therefore, our aim was to compare intubation conditions regarding the modified Cormack &
      Lehane score (CL) between the D-Blade® in indirect laryngoscopy or Macintosh blade in direct
      and indirect laryngoscopy with C-MAC PM® in a simulated setting of a difficult airway in
      human subjects.
    

Intervention name(s): Macintosh blade; D-Blade; Intubation
Intervention type(s): Device; Device; Device
Intervention description(s): Laryngoscopy with C-MAC PM in combination with Macintosh blade; Laryngoscopy with C-MAC PM in combination with D-Blade; Intubation with C-MAC PM in combination with D-Blade
Intervention MeSH terms: Pyrithione zinc
Intervention model: Single Group Assignment
Primary purpose: Treatment
Keywords: difficult airway; carvical collar; endotracheal intubation
Effects of a School-based Exercise Program on Posture, Trunk Range of Motion, and Musculoskeletal Pain
Condition: Musculoskeletal and Connective Tissue Disorders
MeSH terms: Musculoskeletal Pain; Connective Tissue Diseases
Study type: Interventional

Summary: 
      The objective of this study was to evaluate the effects of a school-based exercise program on
      posture, trunk range of motion and musculoskeletal pain in schoolchildren. This study was a
      Randomized controlled trial. The hypothesis was that the exercise group would have the
      postural deviations corrected, would have the trunk range of motion increased and would have
      the prevalence of pain decreased, while the control group would have not. Three schools from
      Brazil participated. The students that have been included (n=300) were randomly allocated to
      experimental (EG) or control group (CG). The intervention for EG consisted in a program based
      on stretching and strengthening exercises, applied twice a week, for eight weeks, with group
      sessions of 50 minutes. CG did not perform any intervention. Qualitative and quantitative
      postural evaluation (PAS/SAPO), musculoskeletal pain (self-report) and trunk mobility were
      collected.
    


Intervention name(s): School-based exercise program
Intervention type(s): Other
Intervention description(s): The exercise program was applied, twice a week, for 8 weeks, with sessions of 50 minutes, in groups of 10 students. The exercise program was elaborate to restore muscular balance through flexibility, endurance and muscular strength. To promote flexibility stretching exercises for rotator neck muscles, lateral neck flexors, levator scapulae, upper trapezius, erector spinae, major and minor pectoralis, rhomboids, spinal lateral flexors, column rotators, piriformis, hamstrings, quadriceps, hip adductors and abductors were applied. Strengthening exercises were applied for the development of strength, endurance and control of deep flexor muscles of the cervical spine, stabilizers of the glenohumeral joint and scapula, abdominals, spine extensors and hip extensors.
Other intervention name(s): Exercise group; Intervention group; Program based on stretching and strengthening exercises
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: posture; child; prevention; muscle strength; muscle stretching exercises; exercise therapy; disease management; musculoskeletal pain; adolescent; spinal curvatures
Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)
Condition: Glaucoma
MeSH terms: Glaucoma; Glaucoma, Open-Angle
Study type: Interventional

Summary: 
      We have completed a study in which we examined the response of the retinal circulation to
      changes in posture from sitting to lying down in patients with primary open angle glaucoma
      (POAG). This alteration in position produces changes in the local blood pressure at the
      entrance to the retinal vasculature. In a healthy retina, the vasculature adapts by dilating
      and constricting in order to maintain a steady blood flow rate. In an eye with POAG, this
      often does not occur. As a result, there are large fluctuations in blood flow which may
      produce the retinal neuronal damage associated with glaucoma.

      The purpose of this study is to demonstrate that topical anti-glaucoma treatments with agents
      that have vasoactive as well as IOP-lowering effects can have a beneficial effect on
      maintaining a steady retinal blood flow rate even when there are changes in local blood
      pressure.
    


Intervention name(s): Dorzolamide 2%-timolol 0.5%; Brimonidine 0.2%-0.5% timolol 0.5
Intervention type(s): Drug; Drug
Intervention description(s): BID OU for 6 weeks; BID OU for 6 weeks
Other intervention name(s): Cosopt; RVD intervention after run-in on timolol 0.5% bid OU; Combigan; RVD intervention after run-in on timolol 0.5% bid OU
Intervention MeSH terms: Timolol; Brimonidine Tartrate; Dorzolamide
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Retinal Vascular Autoregulation
Long-term Sacral Nerve Stimulation for Irritable Bowel Syndrome.
Condition: Irritable Bowel Syndrome
MeSH terms: Irritable Bowel Syndrome; Syndrome
Study type: Interventional

Summary: 
      A recent randomised, controlled, crossover study has shown that sacral nerve stimulation
      (SNS) significantly reduces symptoms and improves quality of life of highly selected patients
      with irritable bowel syndrome (IBS). Relief of IBS symptoms during SNS is associated with
      consistent changes in rectal sensitivity and biomechanical wall properties.

      The aim of the present study is to evaluate long-term efficacy of sacral nerve stimulation on
      symptoms and quality of life in patients with IBS in a randomised, placebo-controlled,
      crossover study.
    

Detailed description: 
      Twenty two patients with IBS-D or IBS-M according to the ROME III criteria, will be enrolled
      by invitation in the study.

      Having meet inclusion criteria, the patients are first set subsensory for 4 weeks and then
      randomised to receive either OFF-subsensory or subsensory-OFF stimulation in a 4+4-week
      period.

      During the PNE test the effect of the stimulation is evaluated by specific IBS symptom and
      quality of life questionnaires (GSRS-IBS and IBS-IS) and bowel habit diaries.
    

Intervention name(s): Subsensory; OFF
Intervention type(s): Device; Device
Intervention description(s): The stimulation is set to 90% of the sensory threshold.; The stimulation is turned OFF.
Other intervention name(s): Device: External pacemaker, model 3625, Medtronic Inc.; Device: External pacemaker, model 3625, Medtronic Inc.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Irritable Bowel Syndrome; Sacral Nerve Stimulation; Symptoms; Quality of Life
Study of IGC-AD1 in Subjects With Dementia Due to Alzheimer's Disease
Condition: Dementia of Alzheimer Type
MeSH terms: Alzheimer Disease; Dementia
Study type: Interventional
Phase: Phase 1

Summary: 
      A single center, randomized, placebo controlled multiple ascending dose study of IGC AD1 to
      evaluate safety and tolerability in subjects with dementia due to Alzheimer's Disease (AD).
    

Detailed description: 
      This is a phase I Multiple Ascending Dose (MAD) study to evaluate safety and tolerability of
      IGC-AD1 in subjects with AD. Twelve subjects will be enrolled. Three different ascending
      doses of the study product will be given: low, medium and high doses. Each dose will be given
      for 2 weeks, followed by a washout period of 4 days. Given the vulnerability of the
      population, a safety cohort of 3 patients (2 active, 1 placebo) will start every dose one day
      ahead of the rest of the patients and will be followed for 24 hours for the development of
      Adverse Events (AEs). Objective criteria will be set after the safety cohort is evaluated.
    

Intervention name(s): IGC AD1; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): IGC AD1 oral Solution; Placebo of IGC AD1 oral Solution
Allocation: Randomized
Intervention model: Sequential Assignment
Intervention model description: 3 dose escalation cohorts in same 12 subjects (5:1 randomization (active:placebo)
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Effects of Cryotherapy on Joint Function and Pressure Pain Threshold in Patients With Subacromial Impingement Syndrome.
Condition: Pain; Inflammation
MeSH terms: Shoulder Impingement Syndrome; Inflammation
Study type: Interventional

Summary: 
      Background: Subacromial impingement syndrome (SIS) is a chronic and disabling disease,
      characterized by compression and mechanical abrasion of the tendons of the rotator cuff
      muscles, subacromial bursa and tendon of the long head of the biceps against the anterior
      surface of the acromion, coracoacromial ligament or the acromioclavicular joint during arm
      elevation movement. After the trauma, inflammatory processes initiate and may lead to loss of
      function when untreated. This inflammation leads the release of cytokines (IL-6, IL-10, IL-1β
      and TNF-α) whose acts as inflammatory mediators. Physical therapy works in treating SIS with
      the goal of reducing pain and inflammatory process. Cryotherapy is widely used in physical
      therapy by anti-inflammatory and analgesic effects, low cost, effectiveness and easy
      application. Objective: The aim of the study is to evaluate the effects of a cryotherapy
      protocol, applied on shoulder of subjects with SIS, on serum inflammatory mediators
      (cytokines) and local pressure pain threshold. Possible changes in function and pain will
      also be evaluated. Materials and Methods: 30 subjects will be selected and share in two
      groups, 15 healthy subjects and 15 subjects with SIS. Function assessments and quality of
      life will be held using the DASH and WORC questionnaires. Cryotherapy will be applied for 4
      consecutive days, lasting 20 minutes without interruption through ice pack over the shoulder
      of SIS carriers. For the blood samples, 20ml of blood will be collected at the first and last
      day of the intervention, and then stored at -80 ° C.
    


Intervention name(s): physical therapy; ice pack
Intervention type(s): Procedure; Other
Intervention description(s): A 20 minutes ice pack cryotherapy applied for 4 consecutive days
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: subacromial impingement; physical therapy; cryotherapy
Effectiveness of Video-Based Rehabilitation Program on Pain, Functionality and Quality of Life in the Treatment of Rotator Cuff Tears
Condition: Rotator Cuff Tear; Pain, Shoulder
MeSH terms: Shoulder Pain; Rotator Cuff Injuries
Study type: Interventional

Summary: 
      The aim of this study was to investigate the efficacy of the video-based rehabilitation
      program on pain, functionality and quality of life in the conservative treatment of partial
      tears of the rotator cuff whether it was as successful as the physiotherapist-supervised
      rehabilitation program.
    

Detailed description: 
      In our study a common exercise program, which can be used in conservative treatment of a
      partial rotator cuff tear, is applied with two different methods; a video-based
      rehabilitation program and physiotherapist-supervised rehabilitation program. Video-based
      rehabilitation program was developed to investigate whether this program is effective on
      pain, functionality and quality of life and as successful as a physiotherapist-supervised
      rehabilitation program.
    

Intervention name(s): Video-Based Rehabilitation Program; Physiotherapist-Supervised Rehabilitation Program
Intervention type(s): Other; Other
Intervention description(s): In both groups, a program consisting of exercises used in conservative treatment of rotator cuff tears was performed. A video record was made by the physiotherapist to a patient where each exercise was described in detail and the patient correctly performed the exercises according to the verbal and visual commands of the physiotherapist. This video record watched by the patients who come to the clinic and patients were asked to do the exercises in the video. Patients did the exercises under control of the physiotherapist in the clinic.; In both groups, a program consisting of exercises used in conservative treatment of rotator cuff tears was performed. Program was carried out by teaching the same exercises individually by the physiotherapist.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: rotator cuff; physiotherapy; video-based rehabilitation; exercise
Compare the Clinical Efficacy of Prototype Toothpastes.
Condition: Gingival Diseases
MeSH terms: Gingival Diseases
Study type: Interventional
Phase: Phase 3

Summary: 
      Evaluate clinical efficacy of a prototype toothpaste on control of dental plaque gingival
      inflammation
    


Intervention name(s): Fluoride; Triclosan and fluoride; Herbal Ingredient and fluoride
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Brush twice daily; Brush twice daily; Brush twice daily
Other intervention name(s): Colgate Great Regular Flavor toothpaste; Colgate Total toothpaste
Intervention MeSH terms: Listerine; Triclosan; Fluorides; Sodium Fluoride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Developing a Physically More Active Lifestyle Based on One's Own Values - RCT Among Sedentary Adults
Condition: Behavior
Study type: Interventional

Summary: 
      The main objective of the study is to provide data of the effectiveness and feasibility of
      the Acceptance and Commitment Therapy in enhancing the physically active lifestyle among
      sedentary adults. The psychological and motivational factors related to physical activity and
      behavior change will also be evaluated.
    

Detailed description: 
      In more detailed the study aimed to investigate the effectiveness of the acceptance- and
      commitment-based behavioural intervention concerning physical activity level and
      self-efficacy, as well as regarding planning and the acceptance of psychological and physical
      discomfort related to physical activity after 3 and 6 months compared to providing only
      individual written feedback on their physical activity. A further aim was to explore
      stability and maintenance of changes in physical activity at the 6 months follow-up. It was
      hypothesised that acceptance- and commitment-based behavioural intervention is more effective
      than feedback only in improving physical activity and related beliefs and cognitions.
    

Intervention name(s): ACT; REF
Intervention type(s): Behavioral; Behavioral
Intervention description(s): The intervention program consists of six group sessions, about 90 minutes per session during the 9 weeks period of time. The group size is about 8-10 members per one group. All the participants get also pedometers for monitoring their physical activity during the intervention.
The program aims to enhance physically active lifestyle and well-being through important life values and build committed action based on the chosen important things. The importance is also placed to a mindful awareness and flexibility to everyday actions related to physical activity. The program don´t include psycho-educational elements or counseling of the health or the health benefits of physical activity.; The participants will get written feedback about their physical activity level after the baseline, and after 3, 6, 9 and 15 months of baseline compared to the current physical activity recommendations. Feedback will be created to illustrate participants´ activity level during the measurement week combining also the information from the diary. Feedback will be posted home and don´t include face to face interaction. As an incentive for participation, participants will also have opportunity to attend a body composition analyze and get short interpretation (15 min) of their own results in the research center.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: physical activity; psychological well-being; acceptance and commitment therapy; adults
Seroquel XR in Schizophrenia Relapse Prevention
Condition: Schizophrenia Relapse Prevention
MeSH terms: Recurrence; Schizophrenia
Study type: Observational

Summary: 
      The purpose of the study is to determine whether the Seroquel XR treatment for 6 months
      improve the relapse prevention in schizophrenic outpatients
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Psychiatric outpatient clinics
      
Keywords: Seroquel XR; schizophrenia relapse prevention
A Study for Assessing Treatment of Patients Ages 10-17 With Bipolar Depression
Condition: Bipolar Depression
MeSH terms: Depression; Depressive Disorder; Bipolar Disorder
Study type: Interventional
Phase: Phase 4

Summary: 
      The main goal of this study is to help answer the following research question(s) and not to
      treat the child's illness.

        -  Can this study drug make children with bipolar depression feel better?

        -  Does this study drug work better than a placebo (sugar pill)?

        -  Does this study drug cause side effects in children who take it?

        -  Is this drug safe to use in children? (The study drug is a mixture of olanzapine and
           fluoxetine)
    


Intervention name(s): Olanzapine Fluoxetine Combination (OFC); Placebo
Intervention type(s): Drug; Drug
Intervention description(s): OFC doses are capsules of 3 milligrams (mg) olanzapine and 25 mg fluoxetine (3/25), 6/25, 12/25, 6/50, or 12/50 mg to be taken orally once daily in the evening for 8 weeks.; Orally, once daily in the evening for 8 weeks.
Other intervention name(s): LY900000; Symbyax
Intervention MeSH terms: Olanzapine; Fluoxetine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Bipolar I Depression