Lung Ultrasound-guided Fluid Resuscitation in Neonatal Septic Shock
Condition: Septic Shock
MeSH terms: Shock, Septic; Shock
Study type: Interventional

Summary: 
      object name: Lung ultrasound-guided fluid resuscitation in neonatal septic shock.

      type of study: prospective observational study. goal of study: The effects of severe
      ultrasound-assisted fluid resuscitation and conventional fluid resuscitation on the prognosis
      of children with neonatal septic shock were compared to evaluate the application value of the
      two techniques in fluid resuscitation of neonatal septic shock.

      research design: In this study, children with neonatal septic shock diagnosed in the neonatal
      intensive care unit of the Second People 's Hospital of Guangdong Province from January
      1,2022 to December 31,2023 were included in the population. According to the different
      monitoring methods used in conventional / clinical shock treatment, 30 cases of fluid
      resuscitation assisted by severe ultrasound, 30 cases of fluid resuscitation assisted by
      NICOM and 30 cases of conventional fluid resuscitation were collected, a total of 90 cases.

      ( 1 ) The demographic data, blood examination and microbiological examination data of the two
      groups at admission were collected.

      ( 2 ) The fluid volume, blood lactic acid, blood pressure, vasoactive drugs ( such as
      dopamine and epinephrine / norepinephrine ), mechanical ventilation, renal replacement
      therapy and antibiotic use were collected before fluid resuscitation.

      ( 3 ) The cumulative fluid infusion volume during fluid resuscitation ( 6 hours ), and the
      use of vasoactive drugs and mechanical ventilation for 6 hours were collected.

      ( 4 ) NICU hospitalization time, cumulative hospitalization time and mortality were
      collected.

      Data collection :

      ( 1 ) The demographic data, blood examination and microbiological examination data of the
      three groups at admission were collected.

      ( 2 ) The fluid volume, blood lactic acid, blood pressure, vasoactive drugs ( such as
      dopamine and adrenaline / norepinephrine ), mechanical ventilation, renal replacement therapy
      and antibiotic use before fluid resuscitation were collected.

      ( 3 ) The cumulative fluid infusion volume during fluid resuscitation ( 6 hours ), and the
      use of vasoactive drugs and mechanical ventilation for 6 hours were collected.

      ( 4 ) NICU hospitalization time, cumulative hospitalization time and mortality were
      collected.
    

Detailed description: 
      Efficacy evaluation: The main efficacy criteria: NICU hospitalization time and cumulative
      hospitalization time, mortality. Secondary efficacy criteria: cumulative fluid volume during
      fluid resuscitation (6 hours), and use of vasoactive drugs and mechanical ventilation for 6
      hours.
    

Intervention name(s): lung ultrasound-guided fluid resuscitation
Intervention type(s): Diagnostic Test
Intervention description(s): For the LUGFR group, therapy was applied based on the same treatment guidelines, and initial lung ultrasonography was performed after enrollment as baseline assessment of lung. The lung ultrasound was conducted using the Doppler ultrasound diagnostic instrument (Philips CX50) at a probe frequency range of 8 to 12 MHz. Lung ultrasonography was conducted using the 12-region method that included the anterior, lateral, and posterior walls on both sides of the lung, which was focused on the condition of A-lines, B-lines (including confluent B-line and compact B-lines), lung consolidation and pleural effusion
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Lung ultrasound; fluid resuscitation; neonatal septic shock