Comparison of Complete Decongestive Therapy With Intermittent Pneumatic Compression for Treatment of Lipedema
Condition: Lipedema
MeSH terms: Lipedema
Study type: Interventional

Summary: 
      Lipedema is a chronic, progressive and hereditary adipose tissue disorder characterized by an
      abnormal increase of subcutaneous adipose tissue, especially in the lower extremities. In
      contrast to obesity, lipoedema may not improve with weight loss and does not include the risk
      of metabolic syndrome such as diabetes, hypertension and dyslipidemia. However, if not
      treated for lipedema, medical complications such as hypermobility, joint problems, walking
      difficulties, and psychological complications such as anxiety and depression may develop.The
      aim of this study was to compare the effects of combined decongestive treatment and
      intermittent pneumatic compression treatment combined with aerobic exercise on pain, quality
      of life and fatigue in patients with lipedema.
    

Detailed description: 
      Lipedema is a chronic, progressive and hereditary adipose tissue disorder characterized by an
      abnormal increase of subcutaneous adipose tissue, especially in the lower extremities. It is
      often seen in female sex. The main determinants of lipedema are bilateral symmetric swelling
      of the hypodermis of the legs which are painful with palpation or spontaneous and easy
      ecchymosis and hematoma with minor trauma.

      Lipedema usually begins in the period of hormonal change in adolescence or after a few years
      and can progress in women during hormone changes such as pregnancy, gynecologic surgery or
      menopause.

      Lipedema is a different diagnosis from obesity, but it can be misdiagnosed as primary obesity
      due to clinical overlap. In contrast to obesity, lipoedema may not improve with weight loss
      and does not include the risk of metabolic syndrome such as diabetes, hypertension and
      dyslipidemia. However, if not treated for lipedema, medical complications such as
      hypermobility, joint problems, walking difficulties, and psychological complications such as
      anxiety and depression may develop.

      However, if not treated for lipedema, medical complications such as hypermobility, joint
      problems, walking difficulties and psychological complications such as anxiety and depression
      may develop.

      Treatment for lipedema includes conservative and surgical options. In conservative treatment
      to control edema, combined decongestive treatment which consists of manual lymphatic drainage
      and compression bandaging, intermittent pneumatic compression and exercise options are
      included.

      The aim of this study was to compare the effects of combined decongestive treatment and
      intermittent pneumatic compression treatment combined with aerobic exercise on pain, quality
      of life and fatigue in patients with lipedema.
    

Intervention name(s): Combined decongestive treatment (CDT) & Combined exercise; Intermittent pneumatic compression & Combined exercise; Combined exercise
Intervention type(s): Combination Product; Combination Product; Combination Product
Intervention description(s): Combined decongestive treatment consists of manual lymphatic drainage and compression bandaging for 30 sessions.; Intermittent pneumatic compression for 5 days a week, for 6 weeks (totally, 30 sessions).; 30 minutes aerobic exercise program including treadmill training consisted of a 5-minute warm-up and cool-down period and 25-minute submaximal aerobic exercise 5 days a week, for 6 weeks. Exercise intensity was calculated from the initial 6MWT. Each session was completed with 15 minutes of strengthening and stretching exercises.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Lipedema; Combined decongestive treatment; Intermittent pneumatic compression