The Status of Parathyroid Hormone Secretion in Covid-19 Patients
Condition: COVID-19 Infection; Parathyroid Gland; Parathyroid Hormone; Calcium; Phosphorus; Alkaline Phosphatase
MeSH terms: COVID-19
Study type: Observational

Summary: 
      COVID-19 infection causes a hypersensitive immune reaction and widespread inflammation in
      various organs of the body, especially through cytokines in the lungs. This cytokine-mediated
      widespread inflammation can also affect the parathyroid glands, resulting in impaired
      parathyroid secretion.

      Researchers evaluated the levels of parathyroid hormone, calcium, phosphorus, and alkaline
      phosphatase in patients hospitalized for COVID-19 infection. Researchers excluded patients on
      intensive care therapy and patients with known parathyroid disease.

      The researchers examined the association of parathyroid hormone secretion with COVID-19
      disease, white blood cells, neutrophil / lymphocyte ratio, C reactive protein, fibrinogen,
      procalcitonin, ferritin, and D-dimer in these patients. The researchers compared the
      parathyroid hormone level of healthy people without COVID-19 infection and known parathyroid
      disease with the parathyroid hormone level of Covid-19 patients.
    

Detailed description: 
      The coronavirus-2 (SARS-COV-2) virus, which can cause severe acute respiratory syndrome
      through the droplet, has caused the global Coronavirus 19 (COVID-19) pandemic. COVID-19
      infection can be asymptomatic or lead to serious illness and even death. This virus causes a
      hypersensitive immune reaction and varying degrees of widespread inflammation through
      cytokines in various organs of the body, mainly the lungs.

      Cytokine-mediated widespread inflammation caused by the virus may also affect the parathyroid
      glands, causing their functions to deteriorate. Thus, it may cause changes in parathyroid
      hormone secretion.

      The researchers evaluated the results of serum parathyroid hormone, calcium, phosphorus,
      alkaline phosphatase tests in patients who were symptomatic and hospitalized with COVID-19
      infection. Participants also evaluated the relationship of parathormone with white blood
      cells, neutrophil / lymphocyte ratio, c reactive protein, fibrinogen, procalcitonin,
      ferritin, and D-dimer in these patients. The researchers compared the parathyroid hormone
      levels of patients with COVID-19 infection with the parathyroid hormone levels of healthy
      individuals without COVID-19 infection and parathyroid disease. So the investigators looked
      for differences in parathyroid hormone levels between both groups. Researchers did not
      include patients in the intensive care unit and patients with known parathyroid disease.
    

Intervention name(s): Venous blood was collected for biochemistry testing
Intervention type(s): Diagnostic Test
Intervention description(s): From the people in the healthy control group, 10 ml of venous blood was collected from the venous vein in the forearm of all individuals in the study. Parathyroid hormone, calcium, phosphorus, alkaline phosphatase levels were measured from this blood.
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Patients who were hospitalized and treated for COVID-19 without parathyroid disease were
        formed.