Peritonsillar Infiltration With Levobupivacaine for Posttonsillectomy Pain
Condition: Pain
Study type: Interventional
Phase: Phase 4

Summary: 
      The investigators aimed to evaluate the effects of different concentrations of preincisional
      peritonsillar levobupivacaine (0.25% ve 0.5%) on postoperative pain and bleeding
    

Detailed description: 
      72 ASA I-II patients between 3 and 12 years of age who scheduled to undergo tonsillectomy
      were enrolled in this randomized, prospective and placebo-controlled study. The indications
      for tonsillectomy were recurrent infections and tonsillar hypertrophy leading to obstructive
      symptoms.

      The patients included to the study were randomly assigned to one of the 3 groups to receive
      different concentrations of levobupivacaine or saline.

      The mean arterial pressure (MAP) and heart rates (HR) of all patients were recorded during
      the whole anesthesia and surgical procedures. The duration of anesthesia and surgery were
      also recorded. Additional remifentanil 1 µgr kg-1 IV was administered to the patients if HR
      was increased by 25 % of the basal value.

      During postoperative period, symptoms such as pain, fever and dysphagia, adverse affects such
      as nausea and vomiting and hemorrhage were evaluated. Pain was evaluated by FLACC (Faces,
      leg, activity, cry, consolability), FPRS (Faces pain rating scale) ve Wong-Baker facies
      scales at postoperative 0, 30 and 60 minutes and 2, 6, 12 and 24 hours. Total analgesic
      consumption during the postoperative period were recorded. If the patients had no
      complication, they were discharged at the postoperative 24th hour.
    

Intervention name(s): Group S; Group LL; Group HL
Intervention type(s): Other; Drug; Drug
Intervention description(s): Peritonsillar infiltration with saline Additional remifentanil 1 µgr kg-1 IV was administered to the patients if HR was increased by 25 % of the basal value.
During postoperative period, symptoms such as pain, fever and dysphagia, adverse affects such as nausea and vomiting and hemorrhage were evaluated. Pain was evaluated by FLACC (Faces, leg, activity, cry, consolability), FPRS (Faces pain rating scale) ve Wong-Baker facies scales at postoperative 0, 30 and 60 minutes and 2, 6, 12 and 24 hours. Total analgesic consumption during the postoperative period were recorded. If the patients had no complication, they were discharged at the postoperative 24th hour.; Peritonsillar infiltration with low-dose of levobupivacaine 0.25%. Additional remifentanil 1 µgr kg-1 IV was administered to the patients if HR was increased by 25 % of the basal value.
During postoperative period, symptoms such as pain, fever and dysphagia, adverse affects such as nausea and vomiting and hemorrhage were evaluated. Pain was evaluated by FLACC (Faces, leg, activity, cry, consolability), FPRS (Faces pain rating scale) ve Wong-Baker facies scales at postoperative 0, 30 and 60 minutes and 2, 6, 12 and 24 hours. Total analgesic consumption during the postoperative period were recorded. If the patients had no complication, they were discharged at the postoperative 24th hour.; Peritonsillar infiltration with high dose of levobupivacaine 0.5%. Additional remifentanil 1 µgr kg-1 IV was administered to the patients if HR was increased by 25 % of the basal value.
During postoperative period, symptoms such as pain, fever and dysphagia, adverse affects such as nausea and vomiting and hemorrhage were evaluated. Pain was evaluated by FLACC (Faces, leg, activity, cry, consolability), FPRS (Faces pain rating scale) ve Wong-Baker facies scales at postoperative 0, 30 and 60 minutes and 2, 6, 12 and 24 hours. Total analgesic consumption during the postoperative period were recorded. If the patients had no complication, they were discharged at the postoperative 24th hour.
Other intervention name(s): Saline; Chirocaine 0.25%; Chirocaine 0.5%
Intervention MeSH terms: Levobupivacaine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: posttonsillectomy pain; levobupivacaine