bioihbjkbjnl/mcl2 huggingface dataset:
A Gluteus Maximus Strength Exercise Effectiveness for Improving Dynamic Postural Control in Female Basketball Players
Condition: Basketball
Study type: Interventional

Summary: 
      The study will be carried out at the Faculty of Nursing and Physiotherapy of the University
      of Alcalá. The study has been approved by the Animal Research and Experimentation Ethics
      Committee of the University of Alcalá. A total of 92 female basketball players aged between
      12 and 25 will be selected and randomized in two different groups.

      The control group will carry out a conventional preventive work out and the experimental
      group will carry out a specific strengthening program for the gluteus maximus in addition to
      the conventional preventive exercises.

      The treatment will take place during the basketball club season and will last 4 months, from
      January to April 2022.

      The objective is to evaluate the effectiveness of the inclusion of a specific gluteus maximus
      strength program in the conventional preventive work to improve the dynamic stability and to
      reduce the injury rate and pain in female basketball players.
    


Intervention name(s): Conventional preventive work out; Gluteus maximus strengthening specific program
Intervention type(s): Other; Other
Intervention description(s): Female players in the control group will carry out a conventional preventive work that is organised in 3 training days per week. First training session includes preventive strength and proprioception exercises. Junior and senior teams (above 16 years old) will also do plyometrics exercises. In the second training session, players will do preventive strength exercises with an increased load compared to the previous session and proprioception exercises. Junior and senior players will also do anaerobic work. In the third session, players will perform reaction speed exercises.; Female players will carry out a gluteus maximus strengthening work out in addition to the control group programme. Of the following four exercises, the first and the third ones will be done on the first training session and the second and the fourth exercises will be done on the second one. Dosage will be 2 sets of 10 repetitions for each leg.
Clam Shell: Lateral decubitus with the knees and hips bend, the working leg placed on top of the other. Separate this knee while feet stay in contact.
Unilateral gluteal bridge: Supine decubitus with one foot flat on the floor and bent knee. This leg pushes the ground with the foot until the pelvis is lifted while the other leg remains straight.
Quadruped hip extension with knee extension : Quadruped on forearms. Straighten the hip by bringing the whole leg up and back with knee extension.
Quadruped hip extension with bent knee: Performed as the previous one, but during this one, the knee of the working leg is bent at 90º.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Dynamic Postural Control; Gluteus Maximus; Lower limb; Injury prevention
Neuromodulation vs. Electrolysis in Plantar Fasciitis
Condition: Plantar Fascitis
MeSH terms: Fasciitis; Fasciitis, Plantar
Study type: Interventional

Summary: 
      The aim of the present study will be the implementation of two protocols in plantar fasciitis
      individuals: a) percutaneous neuromodulation, b) percutaneous electrolysis in plantar fascia.
      Authors hypothesized that percutaneous neuromodulation may have benefits in: pain, quality of
      life, muscular structure.
    


Intervention name(s): Percutaneous neuromodulation in tibial nerve; Percutaneous electrolysis
Intervention type(s): Other; Other
Intervention description(s): The procedure consisted in the application of a square wave biphasic electrical current, with 2-4 Hz frequency, 450 μs pulse during 25 minutes with a needle (0.30mm x 40 mm) inserted proximal to the surface on the tibial nerve.; The procedure consist on placed a needle (0.30mm x 40 mm) on the most hyperalgesic plantar fascia location with a galvanic current of 3mA, 3 times during 3 seconds.
1 time per weeK
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: pain; plantar fasciitis; ultrasound imaging; quality of life
Oral Duloxetine as a Premedication for Postoperative Pain Control
Condition: Anesthesia
MeSH terms: Pain, Postoperative
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of the study is to use duloxetine as premedication in Anterior cruciate ligament
      repair under spinal anesthesia and evaluate the effect on onset and duration of spinal
      anesthesia and postoperative pain control.
    

Detailed description: 
      We designed this randomized, double-blind study to evaluate the effectiveness of
      administration of oral duloxetine 2 hours preoperatively on the onset and the duration of the
      spinal anesthesia in arthroscopic anterior cruciate ligament (ACL) repair and the role of
      duloxetine on postoperative analgesia.
    

Intervention name(s): Duloxetine 60mg; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Duloxetine is a selective SNRI prescribed in depression, anxiety, and chronic pain like diabetic neuropathy and fibromyalgia, it acts through central and peripheral pain modulation; placebo tablets identical to duloxetine tablets
Intervention MeSH terms: Duloxetine Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
Effects of a Ketogenic Diet on Psychological Outcomes
Condition: Overweight; Mood; Appetitive Behavior
MeSH terms: Overweight
Study type: Interventional

Summary: 
      The aim of the study is to investigate how glycemia and ketonemia variations during three
      different diet protocols: a ketogenic diet without any restriction on calories intake (KD), a
      calorie-restricted ketogenic-mediterranean diet (KEMEPHY) and a calorie-restricted
      mediterranean diet (MD) affect appetite, executive functions and mood in overweight young
      women.
    

Detailed description: 
      Fifty overweight young women with a body mass index (BMI) greater than 25 will be randomly
      assigned to a ten days of ketogenic diet (KD), calorie-restricted ketogenic-mediterranean
      diet (KEMEPHY) or Mediterranean diet (MD). All subjects will begin the prescribed diet at the
      beginning of their follicular phase. Body composition, fasting blood glucose and
      β-hydroxybutyrate (BHB), visual analogue scale (VAS) to test appetite as well as
      psychological tests (one mood test and two cognitive tasks) will be obtained 5 days before
      the beginning and on the last day of the diet-period.
    

Intervention name(s): Mediterranean diet; KEMEPHY; KD
Intervention type(s): Other; Other; Other
Intervention description(s): The group received a plan for a isocaloric Mediterranean Diet; The group received a plan for a ketogenic mediterranean with herbal extracts diet; The group received a plan for a low carbohydrate ketogenic diet
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: It is single blind, parallel arms study
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: ketogenic diet; Mediterranean diet; ketones; glycaemia; executive functions
Frequency of Formula Change Prior to the Accurate Diagnosis of Pyloric Stenosis
Condition: Pyloric Stenosis
MeSH terms: Pyloric Stenosis; Gastric Outlet Obstruction; Constriction, Pathologic
Study type: Observational

Summary: 
      The purpose of this study is to determine if there is an increase in the frequency of formula
      change in patients with pyloric sctenosis prior to being correctly diagnosed.
    

Detailed description: 
      The study can be described as a prospective and retrospective study in which information will
      be gathered from questionnaires, analysis of medical records, and the information obtained
      from diagnostic procedures (i.e. Laboratory results, ultrasonography). The time of enrollment
      will be at the time of hospital admission for the study group and the control group. The
      length of time for which the patient will be involved with the study will coincide with the
      length of stay in the hospital. This will be a single center trial involving Maimonides
      Medical center. Approximately 50-100 subjects will be enrolled overall to give the study more
      credibility.

      Methods and Procedures:

      1. Study Participants: All patients admitted to Maimonides Medical Center with a diagnosis of
      pyloric stenosis two to nine weeks of age. Patients will be excluded from the study if there
      is a diagnosed milk allergy, history of prior abdominal surgery, or history of prematurity or
      metabolic disease. Controls will be made up of the same age range, with similar exclusion
      criteria, and will consist of patients admitted for other reasons than listed above, such as
      bronchiolitis and rule out sepsis.

      2: Data: Data will be received through the completion of questionnaire.

      3. Data collection and processing: Questionnaire responses will be analyzed and the responses
      will be statistically analyzed for correlation.

      Benefits: Through participation in this study, patients may help future patients diagnosed
      with pyloric stenosis be brought to the attention of a medical professional.

      Risks: With maintenance of confidentiality, risks to participants in this study are
      negligible.
    

Intervention name(s): Children with pyloric stenosis; Children without pyloric stenosis
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Both cohorts' feeding habits will be observed and recorded for the purposes of comparison; Both cohorts' feeding habits will be observed and recorded for the purposes of comparison
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Male and female children age 2 weeks to 9 weeks, either with pyloric stenosis or without
      
Keywords: pyloric; stenosis
EMST and TMS for Treatment of Dysphagia in Parkinson's Disease
Condition: Parkinson's Disease
MeSH terms: Parkinson Disease
Study type: Interventional

Summary: 
      The purpose of the study is to examine the effectiveness of different methods for the
      treatment of dysphagia in Parkinson's disease (PD). More than 80% of patients suffering from
      PD develop dysphagia during the course of their disease leading to malnutrition, loss of life
      quality, weight loss and pneumonia, which is the leading cause of death in these patients. So
      far, only a few specific treatment approaches have been investigated in PD patients with
      swallowing disorders. The investigator want to compare a 4-week expiratory muscle strength
      training (EMST), transcranial magnetic stimulation (TMS), and combination of both with a sham
      therapy. Dysphagia severity before and after intervention is measured by flexible endoscopic
      evaluation of swallowing (FEES). For the evaluation of changes in cortical swallowing
      processing the investigators apply magnetoencephalography (MEG).
    


Intervention name(s): Expiratory muscle strength training (EMST); Transcranial magnetic stimulation (TMS)
Intervention type(s): Device; Other
Intervention description(s): The EMST is performed 4 weeks, 5 days per week, for 20 minutes per day, using a calibrated or sham, handheld device (EMST 150, Aspire Products, Gainesville, FL).; A sham or active transcranial magnetic stimulation is performed at the last 5 days of EMST training.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A CLinical Study to Evaluate the Safety And Effectiveness of the CeRene DevIce to Treat HeavY Menstrual Bleeding
Condition: Menorrhagia
MeSH terms: Menorrhagia
Study type: Interventional

Summary: 
      The purpose of the study is to evaluate the safety and effectiveness of the Cerene
      Cryotherapy Device in reducing menstrual bleeding in women with heavy menstrual bleeding
      (menorrhagia) due to benign causes for whom child bearing is complete.
    


Intervention name(s): Cerene(R) Cryotherapy Device
Intervention type(s): Device
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: heavy menstrual bleeding; endometrial ablation
Trial Protocol GlobiFer - Oral Iron Repletion
Condition: Iron Deficiency
MeSH terms: Iron Deficiencies
Study type: Observational

Summary: 
      The haemoglobin level of the patients with iron deficiency should be increased clinical
      relevant after 12 weeks treatment with GlobiFer Forte.
    


Intervention name(s): Globifer Forte
Intervention type(s): Dietary Supplement
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        female , ≥ 18 ≤ 60 years of age
      
Keywords: Iron, Hemoglobin, Feritin, erytrocyty. transferin
The Impact of Platelet Functions on Spontaneous Ductal Closure in Preterm Infants
Condition: Patent Ductus Arterioses
MeSH terms: Ductus Arteriosus, Patent
Study type: Observational

Summary: 
      Although thrombocytopenia has been reported as a risk factor for patent ductus arterioses,
      there is lack of data on the function of platelets in ductal closure. Information on
      functions of platelets in ductal closure may change the known model for ductus arterioses and
      may affect the treatment modalities.
    

Detailed description: 
      Patent ductus arterioses is a common problem which involves both pulmonary and cardiac
      outcomes in preterm infants. Although thrombocytopenia has been reported as a risk factor for
      patent ductus arterioses, there is lack of data on the function of platelets in ductal
      closure.

      The investigators aim to investigate the relation between thrombocytopenia and platelet
      functions in pathogenesis of spontaneous ductal closure. The investigators hypothesize that
      Information on functions of platelets in ductal closure may change the known model for ductus
      arterioses and may affect the treatment modalities.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        preterm infants with gestational age below 30 weeks and birth weght lower than 1500 g
      
Keywords: patent ductus arterioses; ductal closure; thrombocyte
The Comparison of Energy in Take and Body Weight EXERCISE
Condition: Exercise; Energy; Body Weight
MeSH terms: Body Weight
Study type: Observational

Summary: 
      This study will compare the effect of two doses of exercise on energy intake and body weight.
      The comparison will be between three groups; two exercise groups and a control group. The
      exercise groups will not be provided with a dietary intervention and the study design also
      includes a non-exercise control group. E-Mechanic trial can make important contributions to
      understanding of the role of exercise dose in weight management. While it is accepted that
      regular exercise plays an important role in general health, the exact role of exercise in
      prevention of weight gain, weight loss and prevention of weight regain remains poorly
      understood despite exercise being widely prescribed for these purposes. The idea that current
      weight management exercise recommendations may produce increased energy intake (or other
      forms on compensation) resulting in disappointing weight loss is an important public health
      issue. The finding of this study could help shape future exercise and weight loss
      recommendations and treatment plans.
    

Detailed description: 
      The purpose of the E-MECHANIC Trial is to test the effect of two doses of exercise on energy
      intake, body weight, body composition, activity levels, and metabolic rate. The exercise
      doses will reflect current recommendations for: 1) general health (8 KKW), and 2) weight loss
      (20 KKW). A non-exercise control group will also be recruited. The primary outcome variables
      are: 1) energy intake, and 2) the discrepancy between expected weight loss and observed
      weight loss. Energy intake will be measured using doubly labeled water and laboratory-based
      food intake tests. Secondary outcome variables include resting metabolic rate, activity
      levels (excluding structured exercise), and body composition. Following a comprehensive
      baseline assessment, participants will be randomly assigned to the 8 KKW, 20 KKW, or control
      group in a 1:1:1 ratio. Additional assessments will be conducted at week 4, with another
      comprehensive assessment at week 24. The week 4 assessment is important to determine if
      endpoints change in the short-term, but not long-term.
    

Observational model: Case-Control
Sampling method: Probability Sample
Study population: 
        The study population group will be 198 sedentary, overweight and obese(BMI levels > 25
        kg/m2 and < 40 kg/m2) individuals. Based on previous studies, we expect to enroll 132
        females and 66 males. Participants will be randomly assigned to an 8 kcal/kg/week, 20
        kcal/kg/week, or control group. The exercise groups will be closely monitored during
        exercise sessions for six months in our exercise-training laboratory.
Drug Interactions and Bioavailability of Cranberry
Condition: Healthy; Drug Interactions
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the potential of cranberry juice to interact with
      conventional drugs. This study will also determine the the amount of cranberry flavonoids
      that appear in the blood and in the urine.
    

Detailed description: 
      The use of cranberry (CB) juice and powders, both alone and in combination with conventional
      medicine, has become more common for the treatment of urinary tract infections (UTIs) and and
      other acute or chronic conditions. Cytochromes P450 enzymes are a group of proteins involved
      in metabolism of certain substances. A group of cytochrome P-450 (CYP) enzymes are
      extensively involved in drug metabolism. The pharmacokinetics of many drugs often vary
      considerably among individuals, largely because of variations in the expression of different
      cytochrome P-450 (CYP) enzymes in the liver and other tissues. Flavonoids are antioxidants
      that may have health benefits. The flavonoids may also be responsible for cranberry's effects
      on urinary tract infections.

      To evaluate the drug interaction potential of cranberry, single doses of the three safe probe
      drugs alprazolam, dextromethorphan, and caffeine will be administered before and after a
      14-day treatment period with cranberry powder. Changes in the pharmacokinetics of these probe
      drugs will indicate the degree of enzyme inhibition or induction. The key pharmacokinetic
      parameters for four major CB flavonoids will be estimated by following the plasma
      concentration versus time course of absorbed flavonoids and their excretion in urine. The
      area under the plasma concentration versus time curve (AUC), oral clearance (Clo), terminal
      elimination half-life (T1/2) and renal clearance (Clren) will be determined for: epicatechin,
      quercetin (total glycosides), procyanidin A2, and cyanidin-3-galactoside.
    

Intervention name(s): Cranberry juice and capsules
Intervention type(s): Drug
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Vaccinium macrocarpon; Antioxidants; Drug Interactions
Nepal Undifferentiated Febrile Illness Trial
Condition: Undifferentiated Febrile Illness
MeSH terms: Hyperthermia; Fever
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of the study is to determine whether azithromycin or cotrimoxazole is the best
      empirical treatment for undifferentiated febrile illness in Nepal
    

Detailed description: 
      Fever is one of the most common presenting symptoms of patients presenting to health centers
      in Nepal. Many of the times, it is difficult to diagnose the cause of the fever by initial
      history, clinical examination and basic laboratory tests and the patents are treated as
      presumed enteric fever or fever without focus needing antimicrobials. In fact there are
      various causes of similarly presenting febrile illnesses including typhoid, paratyphoid,
      murine typhus, scrub typhus etc.

      Many of the traditionally used drugs including fluoroquinolones are now resistant against
      enteric fever in south asia. Oral azithromycin is now commonly used to treat undifferentiated
      febrile illness and remains effective against enteric fever. Many physicians now also use
      co-trimoxazole as it was very commonly used in the treatment of enteric fever in the past.
      Resistance to co-trimoxazole emerged two decades ago, but has subsequently largely
      disappeared and nearly all Salmonella Typhi and Paratyphi A strains from Nepal are now
      susceptible. Anecdotal reports claim that it seems to work very well against undifferentiated
      febrile illness in Nepal; it is largely stocked in government health facilities and is a
      popular and cheap treatment option.

      Both azithromycin and co-trimoxazole are available in Nepal and are extensively used in the
      treatment of undifferentiated febrile illness. Therefore it is important to know the better
      oral option to treat enteric fever and other febrile illnesses and also to have an
      alternative oral treatment in case resistance to azithromycin emerges.

      The investigators purpose to conduct a head to head, parallel group, 1:1, double blinded
      randomized controlled trial to compare azithromycin and co-trimoxazole for the treatment of
      undifferentiated febrile illness and determine the best empirical treatment for
      undifferentiated febrile illness in Nepal.
    

Intervention name(s): Azithromycin; Co-trimoxazole
Intervention type(s): Drug; Drug
Intervention MeSH terms: Azithromycin; Trimethoprim, Sulfamethoxazole Drug Combination
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Undifferentiated febrile illness; Azithromycin; Cotrimoxazole; Efficacy; Enteric fever; Fever clearance time