ZnO Nanoparticles Coated Orthodontic Molar Tube
Condition: Evaluations, Diagnostic Self; Antimicrobial; Orthodontic Appliance Complication; Bacterial Overgrowth; Dental White Spot; Plaque Induced Gingivitis; Plaque, Dental
MeSH terms: Gingivitis; Dental Plaque; Dental Caries
Study type: Interventional

Summary: 
      Orthodontic treatment is an elective procedure to improve the patient's dentofacial
      appearance. The complex design of fixed appliances provides a platform that leads to
      increased plaque accumulation around orthodontic brackets. So, the risk to develop
      demineralization area adjacent to orthodontic brackets is a major barrier in achieving this
      goal. Oral hygiene is greatly complicated following the placement of fixed orthodontic
      Appliances. Molar tube in place are considered for nearly all patients experiencing fixed
      orthodontic therapy over the whole treatment period, which normally lasts 1.5 to 2 years. To
      the best of the authors' knowledge, the application and antimicrobial efficacy of zinc oxide
      (ZnO) nanoparticles coating on orthodontic molar tube material has not been integrated
      clinically. White spot lesions during orthodontic treatment have a documented etiology.
      Briefly, the accumulation of plaque and food around brackets, bands, wires, and other
      attachments caused decreased pH and increased S. mutans colonization, which led to the
      possibility of clinical demineralization.

      The aims of study are to assess the antimicrobial effect of nanoparticle coated stainless
      steel orthodontic molar tube material (OMT) with zinc oxide (ZnO) nanoparticles in relative
      to uncoated orthodontic molar tube (UOMT) against the streptococcus. mutans& lactobacllius
      bacteria that cause white spot lesion around the fixed orthodontic appliance. .
    

Detailed description: 
      Aim:

      The aim of this prospective randomized clinical trial is to assess the antimicrobial efficacy
      of nanoparticle coating stainless steel orthodontic molar tube (OMT) with zinc oxide (ZnO)
      nanoparticles in relative to uncoated orthodontic molar tube (UOMT).

      Objectives:

        1. Compare the antimicrobial properties of the zno nanoparticle coated OMT in relative to
           uncoated orthodontic molar tube (UOMT).

        2. Evaluate and compare the clinical bond failure rate between the coated OMT and the UOMT.
           The null hypothesis is that there is no significant difference in the antimicrobial
           effects and the rate of bond failure between the non-coated and coated stainless steel
           orthodontic molar tube using ZnO NPs.
    

Intervention name(s): Zinc oxide nanoparticle coated orthodontic molar tubes (experimental); orthodontic molar tubes (control)
Intervention type(s): Device; Device
Intervention description(s): nine orthodontic patients each one will receive 2 coated zinc oxide nanoparticle molar tubes in split-mouth manner and will assess for antimicrobial effect on s. mutans & lactobacillus after two weeks, in addition to evaluation of bond failure rate after three months.; nine orthodontic patients each one will receive two uncoated molar tubes in split-mouth manner and will assess for antimicrobial effect on S. mutans & lactobacillus after two weeks, also, evaluation of the bond failure rate after three months period.
Intervention MeSH terms: Zinc Oxide
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 72 orthodontic molar tubes will be divided in two groups control 36 uncoated OMT, and 36 experimental groups that will receiving the zinc oxide nanoparticle coating.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Nanoparticles; zinc oxide nanoparticle; coating; orthodontic molar tube; electrophoretic deposition cell; EPD CELL; nanomaterials; antimicrobial effect; bacterial culture