bioihbjkbjnl/mcl2 huggingface dataset:
Immediate Effects of Postural Repositioning on Voice Production Tasks in Seated Individuals With Acquired Dysarthria:
Condition: Acquired Dysarthria (Finding)
MeSH terms: Dysarthria
Study type: Interventional

Summary: 
      To determine the effectiveness of a single 10-min postural repositioning session on the
      maximum phonation duration in individuals with acquired dysarthria.
    

Detailed description: 
      The impact of dysarthria goes beyond communication. However, there have been no clear
      directives guiding clinical practice to date, and despite increasing evidence directing
      treatment, research remains limited and predominantly consists of case studies or case
      series. Despite the importance of postural control in voice production, the effects of
      postural alignment on speech production efficiency are either little investigated or not at
      all explored in the dysarthric population. This study determined the effectiveness of a
      single 10-min postural repositioning session on the maximum phonation duration (MPD) in
      individuals with acquired dysarthria.
    

Intervention name(s): postural repositioning
Intervention type(s): Other
Intervention description(s): The 10-min transdisciplinary intervention aimed (1) to facilitate and activate axial extension during standing and then during sitting; (2) to actively mobilize the trunk, cervical spine, and pelvic and shoulder girdles during standing and then during sitting; and (3) to adjust the seated position, as needed, with supports to ensure its maintenance throughout the experiment. Cushion, balls, boxes, or rolls were used to stabilize the final seated position.
Intervention model: Single Group Assignment
Intervention model description: pilot study
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: acquired dysarthria; corrected seated posture; maximum phonation duration; electromyographic patterns
Physical Exercise in Hypertension, Randomised Clinical Trial
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      Endurance training has a documented effect on hypertension. However, only low to moderate
      training intensity has so far been studied. High aerobic intensity should, from physiological
      considerations, prove more effective in also reducing high blood pressure. The present study
      is a randomised comparison of high versus moderate intensity versus training in groups, and
      general advice on 24 hour blood pressure in hypertensives. The training period is 12 weeks,
      with follow-up after 1 year. Maximum oxygen uptake, quality of life, left ventricular
      function and blood vessel reactivity are also measured.
    

Detailed description: 
      Endurance training has documented effect on blood pressure in hypertension. However, only low
      to moderate training intensity has so far been studied. Higher aerobic intensity based on
      individual measurements of maximum oxygen uptake is more efficient in increasing oxygen
      uptake, and might prove more effective in lowering blood pressure. Group training, on the
      other hand is not individualised, but less personnel required and may prove more cost
      effective. Endurance training is shown to improve both systolic and diastolic left
      ventricular function, as well as endothelial function. Both can be measured non-invasively by
      ultrasound.

      The study is an open, randomised study with four arms, comparing:

        -  High aerobic intensity interval training

        -  Moderate aerobic intensity training

        -  Group training

        -  Controls receiving standard advice on lifestyle and training

      Training effect is measured by Max. Oxygen uptake, blood pressure by continuous 24 hour
      ambulatory measurement, Left ventricular function by echo Doppler and endothelial function by
      flow mediated vasodilation by ultrasound.

      The effect of exercise on blood pressure is dependent on continued training. All patients
      will be followed up after one year.
    

Intervention name(s): Aerobic interval training; moderate intensity training; Recommendation of regular exercise
Intervention type(s): Behavioral; Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Hypertension; endurance training; endothelial function; left ventricular function; Echocardiography; Quality of life; Essential hypertension grade 1 - 2
Comparison of the Proximal Approach and Distal Approach of Axillary Vein Catheterization Under Ultrasound Guidance
Condition: Central Venous Catheterization
Study type: Interventional

Summary: 
      Ultrasound-guided axillary vein catheterization can be performed via the proximal or distal
      approach of the axillary vein. The aim of our study is to compare the first puncture success
      rate and safety between the two approaches of ultrasound-guided axillary vein catheterization
      in cardiac surgical patients with risk of bleeding.
    

Detailed description: 
      For patients after cardiac surgery, antiplatelet drugs or anticoagulants are usually used for
      preventing thrombosis. Use of those drugs is associated with increased risk of bleeding. Any
      invasive procedures may put those patients at additional risk of bleeding. Ultrasound (US)
      has become widely accepted to guide safe and accurate central venous catheterization.The
      axillary vein in the infraclavicular area is an alternative choice for subclavian vein.
      Ultrasound images of the infraclavicular axillary vein differ according to its position.
      Proximal infraclavicular axillary vein is a direct continuation of the subclavian vein. The
      associated anatomy is simple and the vein is straight and thick in longitudinal axis view,
      which are in favor of successful puncture. Meanwhile, distal axillary vein also has
      anatomical advantages for safe and successful cannulations. Distal axillary vein lies further
      away from the artery and chest wall, and the overlap between distal axillary vein and artery
      gets greater on moving laterally. It is still unknow that one of the puncture approaches is
      superior to the other. Until now, there are no studies comparing two puncture approaches in
      high bleeding risk patients. The aim of the study is to compare the success rate of first
      puncture and safety of US-guided proximal and distal axillary venous catheterization in
      cardiac surgery patients with risk of bleeding.
    

Intervention name(s): The distal approach; The proximal approach
Intervention type(s): Procedure; Procedure
Intervention description(s): The first two attempts via the distal approach will be performed . If the first two attempts failed, the subsequent attempts of venipuncture were performed using the proximal approach; The first two attempts via the proximal approach will be performed . If the first two attempts failed, the subsequent attempts of venipuncture were performed using the distal approach.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: axillary vein; central venous catheterization; ultrasound; cardiac surgery; complication
Spinal Stabilization Exercises in Individuals With Transtibial Amputatıon
Condition: Amputees; Exercise Training; Physiotherapy; Energy Metabolism
Study type: Interventional

Summary: 
      Lower extremity amputation causes rapid changes in musculoskeletal system. With the effect of
      these changes, the energy requirement for prosthetic ambulance is much higher than normal
      ambulance. Although methods such as the reduction of the segmental load of the prosthesis and
      the preference of the different prosthetic components for energy expenditure have been
      emphasized, the effect of exercise types has not been investigated in our knowledge.
      Therefore, the aim of the current study is to investigate the effect of spinal (Core)
      stabilization exercises on energy expenditure in combination with the classical physiotherapy
      program in patients with unilateral transtibial amputation. Individuals with transtibial
      amputation included in the study will be randomly divided into two groups. In group 1, basic
      exercises related to amputation will be applied for 8 weeks and in group 2 basic exercises
      with spinal stabilization exercises will be applied to the individuals. At the beginning and
      at the end of the exercise intervention, energy expenditure and exercise capacity will be
      evaluated by a portable exercise test device during '6 Minutes Step Test'; fatigue assessment
      will be done before and after 6 Minutes Step Test with 'Modified Borg Scale'; the strength of
      deep spinal muscles will be evaluated with 'Stabilizer'; dynamic balance and functional
      mobility will be evaluated by 'Timed Up & Go' Test; and the effect of the prosthesis on
      mobility will be evaluated by the sub-scale 'Mobility' of 'Prosthetic Evaluation
      Questionnaire'.
    


Intervention name(s): Exercise BE; Exercise BE+SS
Intervention type(s): Other; Other
Intervention description(s): Basic exercises related to amputation will be applied; Basic exercises related to amputation + Spinal stabilization exercises will be applied
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: amputees; rehabilitation; energy expenditure; deep muscles of the back
PERFECT Project - Part 2 - Study 2
Condition: Diabetes Prevention; Obesity Prevention
Study type: Interventional

Summary: 
      The objectives are to test the acute effects of different cereals containing pulse
      ingredients on: 1) aerobic endurance and substrate oxidation during exercise 2) response of
      blood glucose, insulin and appetite to an aerobic exercise session, and 3) food intake two
      hours following the exercise session. The investigators hypothesize that consumption of
      cereals containing pulse ingredients 60 minutes before exercise will increase aerobic
      endurance (lower oxygen consumption), decrease carbohydrate oxidation (greater respiratory
      quotient), and a reduction in lactate production during compared to the same exercise session
      following the ingestion of a non-pulse food. The investigators also hypothesize that
      consumption of cereals containing pulse ingredients will lead to lower blood glucose,
      insulin, appetite and food intake, suggesting lower calorie compensation, following a
      60-minute aerobic exercise session compared to the same exercise session following the
      ingestion of a non-pulse food.
    


Intervention name(s): Control; Pea protein; Pea Starch; Pea fibre + pea starch; Pea protein + pea starch; Pea fibre + pea starch + pea protein
Intervention type(s): Other; Other; Other; Other; Other; Other
Intervention description(s): Non pulse extruded cereal; Pulse extruded cereal; Pulse extruded cereal; Pulse extruded cereal; Pulse extruded cereal; Pulse extruded cereal
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
High-need Community Older Adults Care Delivery Model
Condition: High-need Older Adults
Study type: Interventional

Summary: 
      This study is proposed to: (1) establish a "High-need Community Older Adults Care Delivery
      Model" (HCOACDM) as a guide to handle complex needs of the high-need community older adults
      by the care managers at community care centers; and (2) evaluate the effectiveness of
      applying the HCOACDM to improve the functional ability, quality of life (QOL), depressive
      symptoms, healthcare and social service utilizations, and care delivery satisfaction of the
      high-need community older adults.
    

Detailed description: 
      A cluster randomized controlled trial with repeated measures design will be conducted to test
      the effectiveness of six-month HCOACDM on the functional ability, QOL, depressive symptoms,
      healthcare and social service utilizations, and care delivery satisfaction of the high-need
      community older adults. The high-need community older adults, screened based on the
      "High-need Community Older Adults Screening Scale" (HCOASS), will be cluster randomized based
      on the community care centers, to the intervention group (4 centers) or comparison group (4
      centers). Intervention group will receive six-month HCOACDM care and comparison group will
      receive original routine care provided by the care managers at community care centers. One
      pre-test and two post-tests, three months apart, of outcome measurements will be conducted on
      all participants. Moreover, individual semi-structured interviews will be carried out to
      explore opinions and suggestions toward the HCOACDM of the care managers in intervention
      group. It is expected that the developed HCOACDM will be useful to provide the long-term care
      for community older adults and enhance the quality of diverse and complex care delivery
      system.
    

Intervention name(s): HCOACDM; Routine care
Intervention type(s): Other; Other
Intervention description(s): The intervention, the HCOACDM, involves case screening, comprehensive assessment, and care coordination, and will be given over a 6-month period.; The routine care services include home visits, telephone checkups, meals on the wheel, and health promotion activities.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Achieving Control of Asthma in Children In Africa
Condition: Asthma
MeSH terms: Asthma
Study type: Observational

Summary: 
      The main aim of the study is to identify altogether 3000 children aged between 12 and 16
      years old with asthma symptoms in six sub-Saharan African countries. The study furthermore
      aims to assess their asthma control, current treatment, knowledge of and attitudes to asthma,
      as well as the barriers to achieving good asthma control.
    

Detailed description: 
      Asthma prevalence in young people has been rising in several African countries during the
      last decade, reaching between 10% and 20% in Central Africa, and up to 20% in South Africa.
      In addition, asthma related mortality in many African countries is high. South Africa has the
      third highest asthma related mortality rate in the world. Yet to date, a lack of asthma
      research and research infrastructure means that we do not have the evidence to either inform
      advocacy or to develop interventions that improve asthma outcomes.

      This study aims to collect data about asthma prevalence and to identify existing barriers to
      effective asthma management of young people in 6 sub-Saharan countries: Malawi, South Africa,
      Zimbabwe, Uganda, Ghana, and Nigeria. Each of these countries identifies 500 young people
      with asthma between 12 and 16 years of age through a screening questionnaire in schools.
      These 3000 young people with asthma symptoms fill in a survey about asthma, including
      questions around asthma control, current treatment and access to care, asthma knowledge,
      asthma attitudes, smoking and environmental influences. Some of the participants also discuss
      asthma related topics in focus groups. A subset of the participants furthermore do Spirometry
      and FeNO testing. In addition to the data collection, the study develops and tests options
      for an intervention aimed at improving asthma control, including the adaption of a United
      Kingdom - based theater play about asthma awareness. The development of WiFi infrastructure
      and IT solutions is promoted by the study, where appropriate.
    

Observational model: Ecologic or Community
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Young people between 12 and 14 years of age.
      
Keywords: FeNO; Africa; Spirometry; Asthma Control; ACT; Prevalence
Testing the Veggie Brek Intervention
Condition: Nutrition, Healthy
Study type: Interventional

Summary: 
      This programme of work aims to investigate the feasibility and acceptability to both children
      and nursery staff of offering vegetables to children at breakfast time at nursery. Research
      will be completed to assess the feasibility of undertaking a subsequent cluster randomised
      controlled trial (RCT) on this question.
    

Detailed description: 
      Children are not eating a sufficient amount of fruit and vegetables to ensure optimal health
      and development. Interventions are needed to help increase fruit and vegetable intake from
      the early years of children's lives, to support the development of lifelong healthy eating
      habits and the acceptance of vegetables as an important element of a normal diet. Vegetables
      are often refused by young children due to their often-bitter tastes, and so efforts to
      increase children's intake of vegetables is a health priority. Vegetables are not commonly
      offered at breakfast time, which reduces the opportunities each day for vegetables to be part
      of children's routine diets. Therefore, it is important to understand whether children will
      be willing to eat - or at least try - vegetables when offered alongside a usual breakfast
      food (e.g., cereal or toast). Preschool children eat many meals in childcare settings
      therefore nurseries provide an ideal setting in which to test whether the addition of
      vegetables at breakfast is feasible and acceptable to both children and nursery staff. This
      research will recruit nurseries in the East Midlands, UK, to investigate whether children and
      nursery staff are willing and able to offer (and eat) vegetables at breakfast. The study will
      adopt a feasibility cluster randomised controlled trial design where nurseries will be
      randomly allocated to deliver the Veggie Brek intervention or usual breakfast every weekday
      for three weeks. There will be a baseline period and follow-up period of five days where
      vegetables will be offered to children at breakfast.

      Data will also be collected to understand the nursery staff's views on the study and how
      easy/difficult the study's procedures were to implement (e.g., were instructions clear and
      could be followed, were there any barriers to offering vegetables at breakfast). This
      information will be used to inform the feasibility and acceptability of a later trial.
    

Intervention name(s): Veggie Brek
Intervention type(s): Behavioral
Intervention description(s): Offering vegetables to children at breakfast alongside their main breakfast food for three consecutive weeks (five days a week) between baseline and follow-up weeks where vegetables are also offered to children at breakfast alongside their main breakfast food for five days a week.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Single-centre interventional cluster randomised controlled trial
Masking: None (Open Label)
Primary purpose: Prevention
Combination of AB-LIFE Probiotic Plus Monacolin K to Reduce Blood Cholesterol
Condition: Hypercholesterolemia
MeSH terms: Hypercholesterolemia
Study type: Interventional

Summary: 
      This randomized study evaluates the effectiveness of a nutraceutical combining billion colony
      forming units (cfu) of three L. plantarum strains (CECT7527, CECT7528 and CECT7529) and 10 mg
      of monacolin K in reducing blood cholesterol.
    

Detailed description: 
      Cardiovascular diseases (CVDs) are the number 1 cause of death globally, and retention of
      low-density lipoprotein cholesterol (LDL-C) and similar cholesterol-rich lipoproteins
      containing apolipoprotein B (ApoB) within the arterial wall is a key initiating event in
      CVDs. Statins are the mainstay of pharmacological cholesterol-reduction therapy. However, a
      significant proportion of patients report some degree of statin intolerance, which typically
      fade away when the statin is switched, discontinued or the dosage reduced. A growing
      attention has been devoted to the correction of increased LDL-C levels through the use of
      dietary supplements, either because some patients have milder forms of hypercholesterolemia
      or as an alternative to statins in patients who may have experienced or are worried of side
      effects. Nutraceutical combinations are increasingly used in clinical practice. In this pilot
      randomized study, we sought to evaluate of the effect on LDL-C and other blood lipid
      parameters of a nutraceutical combining Red Yeast Rice extract (also known by its scientific
      name Monascus purpureus) containing 10 mg of monacolin K, plus 1 billion colony forming units
      (cfu) of the AB-LIFE probiotic formula. The later is composed of three L. plantarum strains,
      namely CECT7527 (also known as KABP011™), CECT7528 (also known as KABP012™) and CECT7529
      (also known as KABP013™).
    

Intervention name(s): AB-LIFE with Monacolin K; Placebo
Intervention type(s): Dietary Supplement; Other
Intervention description(s): Red yeast rice extract (also known by its scientific name, Monascus purpureus) certified to contain 10 mg of monacolin K, plus 1 billion total cfu of AB-LIFE probiotic formula, which is composed of 3 Lactoplantibacillus plantarum (formerly known as Lactobacillus plantarum) strains: CECT7527 (also known as KABP011™), CECT7528 (also known as KABP012™) and CECT7529 (also known as KABP013™), all in a maltodextrin carrier. Capsules are of vegetable origin (hydroxypropylmethyl cellulose).; Placebo capsules containing maltodextrin carrier only. Capsules are of vegetable origin (hydroxypropylmethyl cellulose).
Intervention MeSH terms: Lovastatin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Probiotic; Lactobacillus; Monacolin K; Monascus purpureus
Study to Evaluate the Mass Balance and Biotransformation of [14C]-Fluzoparib in Chinese Patients With Solid Tumor
Condition: Solid Tumor
MeSH terms: Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      Study to Evaluate the Mass Balance and Biotransformation of Single Dose [14C]-FZPL in Chinese
      Patients with Solid Tumor
    


Intervention name(s): [14C]-Fluzoparib
Intervention type(s): Drug
Intervention description(s): Patients will receive single dose of orally [14C]- Fluzoparib on Day 1.
Intervention MeSH terms: Fluzoparib
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Solid Tumor; 14C-Fluzoparib