Concentrated Growth Factors in Treatment of Intrabony Defects in Localized Aggressive Periodontitis
Condition: Aggressive Periodontitis
MeSH terms: Periodontitis; Aggressive Periodontitis; Aggression
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      A total of 20 intra-bony defects in 10 LAP patients were randomly assigned into two groups 10
      defects each in a split-mouth design. Group I treated by surgery plus Bio-Oss bone graft +
      collagen membrane (Control group). Group II, treated by surgery plus Bio-Oss bone graft + CGF
      membrane (Test group). Gingival index (GI), bleeding on probing (BOP), probing pocket depth
      and clinical attachment level (CAL) were assessed at baseline, 3, 6, and 12 months. Cone beam
      radiograph evaluation was taken at baseline, and 12 months after surgery..
    

Detailed description: 
      Full mouth scaling and root planing was done for all patients followed by Augmentin I gm and
      metronidazole 500 mg twice daily for 7 days. Additionally, Comprehensive oral hygiene
      instructions were given to the patients.

      Sites grouping Four weeks following phase I therapy, the twenty defect sites were randomly
      classified by sealed envelopes into two groups ten each by a masked supervisor as follows:
      Group I (10 sites) received surgery + Bio-oss bone graft (Geistlich Pharma AG, Wolhusen,
      Switzerland) + collagen membrane (control group). Group II (10 sites) received surgery +
      Bio-oss bone graft +concentrated growth factors membrane (tested group).

      After the administration of local anesthesia (Xylocaine 2% Adrenaline 1:80,000, ICPA, India),
      buccal and lingual sulcular incisions were made, and mucoperiosteal flaps were elevated.
      Thorough debridement of the defects was achieved with hand instruments. The surgical area was
      irrigated with copious amounts of sterile saline. Bio-oss granules were placed into the
      defects and the CGFs membrane was trimmed and adapted over the entire defect to cover 2-3 mm
      of the surrounding alveolar bone and to ensure the stability of the wound and the graft
      material. For control sites, Bio-oss grafts and a bioresorbable collagen membrane were
      trimmed and adjusted over the defect in such a way that the whole defect and 2-3 mm of the
      surrounding alveolar bone were completely covered. Then the flap was repositioned to achieve
      complete interproximal closure. The flap was then sutured with 4-0 absorbable sutures with
      single interrupted sutures. A periodontal pack was applied over the surgical area for 10
      days.
    

Intervention name(s): GTR; concentrated growth factor
Intervention type(s): Procedure; Procedure
Intervention description(s): intrabony defects treated by surgery and bone graft +collagen membrane; intrabony defects treated by surgery and bone graft +concenrated growth factor membrane
Other intervention name(s): regenerative surgery; regenerative surgery
Intervention MeSH terms: Mitogens
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Twenty intra-bony defects in 10 patients were randomly assigned to either test or control group in split-mouth technique (10 sites in each group).
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: aggressive periodontitis; intrabony defect,; concentrated growth factors membrane