Evaluation of Effect of Intravenous Morphine vs Intravenous Ibuprofen and Acetaminophen vs Intravenous Ibuprofen
Condition: Multiple Trauma; Acute Pain Due to Trauma
MeSH terms: Acute Pain; Wounds and Injuries; Multiple Trauma
Study type: Interventional
Phase: Phase 3

Summary: 
      Pain is an inseparable symptom of fractures and is the most important and common symptom that
      brings patients to medical centers; Therefore, paying attention to pain and its control is
      very important in the examination and treatment of fractures, and painkillers are usually
      needed for effective pain control. About 70-90% of the patients who go to the emergency room
      due to injuries have organ injuries. Among these patients, those who suffer from fractures
      endure severe pain, and since only 10% of patients have open fractures, the pain management
      of patients with closed fractures is particularly important. Various medicinal compounds have
      been used so far to control the pain of fractured patients, including opioid compounds such
      as morphine, non-steroidal anti-inflammatory drugs such as ibuprofen and acetaminophen.
      Opioids are the main drug class for pain control in fractures, but since they have
      significant side effects, various studies have been conducted in the field of comparing the
      anti-inflammatory effect of different drugs in fractures, and the effect of various
      combinations compared to opioids has been investigated. Non-steroidal anti-inflammatories are
      always considered as an alternative to opioids and acetaminophen has also been considered to
      reduce the dosage of opioids, so in this study the effect of three combinations of
      intravenous morphine and ibuprofen plus intravenous acetaminophen and intravenous ibuprofen
      on pain levels in patients with a closed limb fracture will be investigated.

      This study is a blind randomized clinical trial, which investigates and compares the effect
      of intravenous morphine (Daropakhsh Company) with intravenous ibuprofen (Caspian Taamin
      Company) and intravenous acetaminophen (Caspian Taamin Company) with intravenous ibuprofen
      (Caspian Taamin Company) in reducing the pain of patients with closed limb fractures. The
      population investigated in this study will include all patients referred to the emergency
      room of Al-Zahra and Ayatollah Kashani educational centers in Isfahan city in 2022-2023.
    

Detailed description: 
      The study subjects are classified into 3 groups by computerized random allocation method, the
      first group will receive 0.1 mg/kg of intravenous morphine (Daropakhsh company) and the
      second group will take 400 mg of intravenous ibuprofen (Caspian Taamin company) plus 1 gram
      of intravenous acetaminophen (Caspian company). Tamin) and the third group receives 800 mg of
      intravenous ibuprofen (Caspian Taamin Company).This study is a blind randomized clinical
      trial, which investigates and compares the effect of intravenous morphine with intravenous
      ibuprofen and intravenous acetaminophen with intravenous ibuprofen.
    

Intervention name(s): Ibuprofen 800 mg; Morphine Sulfate; Ibuprofen 400 mg plus Acetaminophen 1000 mg
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Ibuprofen from Caspian Taamin Company; Morphine Sulfate from Darupakhsh Company; Both from Caspian Taamin Company
Intervention MeSH terms: Acetaminophen; Ibuprofen; Morphine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment