Evaluation of the Efficacy of Different Drugs in the Treatment of the Pain in Patients With Temporomandibular Disorder
Condition: Temporomandibular Disorder
MeSH terms: Temporomandibular Joint Disorders; Temporomandibular Joint Dysfunction Syndrome
Study type: Interventional
Phase: Phase 4

Summary: 
      The most important step in the treatment of TMJ (temporomandibular joint) disease in clinical
      dentistry is diagnosis and planning. The clinical findings, drug requirement and biological
      risk of the patients determine the examination methods to be used in the Treatment of
      Temporomandibular Joint Disorders. In this context, it is thought that studies in the field
      of dentistry should be increased in order to increase the success in the treatment of TMJ
      Disorders. The aim of the study is to evaluate the efficacy of of different pain relievers as
      Dexketoprofen Trometamol + Thiocolchicoside, dexketoprofen trometamol + paracetamol and
      Dexketoprofen Trometamol in the treatment of pain in TMJ disorders.
    

Detailed description: 
      The study was carried out on 200 patients aged 18 and over, who applied to Van Yuzuncu Yıl
      University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, with
      complaints of pain due to temporomandibular disease. When patients first applied to the
      clinic, their anamnesis were taken and they were directed to MR (Magnetic Resonance) imaging
      after clinical evaluation. Patients who meet the inclusion criteria and volunteer were
      included in the study. Patients were randomly divided into 4 groups. Medications were given
      to patients by auxiliary staff and the study was double-blind. Medicines were given as
      follows. Dexketoprofen Trometamol + Thiocolchicoside (25mg + 4mg, 2x1) in the 1st group,
      Dexketoprofen Trometamol + Paracetamol (25mg + 300mg, 2x1) in the 2nd group, only
      Dexketoprofen Trometamol (25mg, 2x1) in the 3rd group and paracetamol 500 mg in the 4th
      control group (4x1) were given. In addition, patients in each group used occlusal plate for a
      minimum of 8 hours per day (at night). Medicines were used regularly for 2 weeks. Paracetamol
      500 mg was used only if needed for the next 2 weeks. The pain values of the patients was
      evaluated with the VAS scale, and the amount of mouth opening was evaluated by measuring the
      distance between the incisal edges of the lower and upper central teeth. Evaluations have
      been done at the beginning of the treatment and at the 1st week, 2nd week, 1st month and the
      3rd month and the findings were recorded. After the 1st month, the patients were followed up
      to the 3rd month and the treatment of those who need additional treatment were continued.
      Obtained data will be analyzed and evaluated statistically.
    

Intervention name(s): Dexketoprofen Trometamol + Thiocolchicoside; Dexketoprofen Trometamol + Paracetamol; Dexketoprofen Trometamol (25mg); Paracetamol
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Dexketoprofen Trometamol + Thiocolchicoside (25mg + 4mg) is a NSAID. It was given to the patients twice a day.; Dexketoprofen Trometamol + Paracetamol (25mg + 300mg) is a NSAID. It was given to the patients twice a day.; Dexketoprofen Trometamol (25mg) is a NSAID. It was given to the patients twice a day.; Paracetamol (500 mg) is a mild analgesic and antipyretic. It was given to the patients to take only if needed as max. dose 2000mg.
Intervention MeSH terms: Acetaminophen; Dexketoprofen trometamol; Ketoprofen
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment