bioihbjkbjnl/mcl2 huggingface dataset:
Shoulder Exercises in Hypermobile Patients With Shoulder Symptoms
Condition: Hypermobility Syndrome Shoulder; Shoulder Pain Chronic; Shoulder Luxation
MeSH terms: Shoulder Pain; Shoulder Dislocation
Study type: Interventional

Summary: 
      Hypermobility Spectrum Disorder (HSD) is a recent diagnosis that covers generalised joint
      hypermobility with one or more secondary symptomatic musculoskeletal manifestations. Current
      clinical management of this population with shoulder symptoms is based on limited evidence
      and includes a combination of non-specific physiotherapy modalities and exercise
      prescription. There is some evidence suggesting that strength training may be valuable for
      treatment of this patient-group. Therefore, the aim of this study is to evaluate the
      effectiveness of a heavy shoulder strengthening exercise programme in patients with HSD and
      shoulder symptoms.
    

Detailed description: 
      Hypermobility Spectrum Disorder (HSD) is a recent diagnosis that covers generalised joint
      hypermobility with one or more secondary symptomatic musculoskeletal manifestations such as
      chronic shoulder pain and shoulder instability. The evidence for treatment is sparse, but
      current clinical management of this patient-group with persistent shoulder symptoms is a
      combination of non-specific physiotherapy modalities and exercise prescription. There is some
      evidence suggesting that strength training may be valuable for treatment of this
      patient-group. The intervention consisting of heavy shoulder strengthening exercises has
      recently been tested to be feasible, and since clinical improvements were seen, the
      intervention is ready to be studied in a randomised controlled trial. Therefore, the aim of
      this study is to evaluate the effectiveness of a heavy shoulder strengthening exercise
      programme and general advice as compared to shoulder stability exercises and general advice
      (current standard care) in patients with HSD and persistent shoulder symptoms. The primary
      hypothesis is that a heavy shoulder strengthening exercise programme is superior to standard
      care.

      Sample size considerations: a clinically significant effect of 252 points or more out of 2100
      points (SD = 350 points) between the two groups over the 16 weeks is desired, which with a
      two-sided significance of 0.05, a power of 0.9, and 16% dropout, requires a total of 100
      patients. In case 100 patients are not included within 24 months, a stopping rule will be
      applied as soon as at least 76 patients are included, corresponding to a power of minimum
      0.8.
    

Intervention name(s): Exercise
Intervention type(s): Other
Intervention description(s): The exercise programme includes exercises identified in literature to target scapular and rotator cuff muscles.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Joint instability; Hypermobility; Shoulder; Strength training
MK0249 for the Treatment of Cognitive Impairment in Patients With Schizophrenia (0249-016)
Condition: Paranoid Schizophrenia
MeSH terms: Schizophrenia; Cognitive Dysfunction; Schizophrenia, Paranoid
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine the safety and effectiveness of an investigational
      drug MK0249 for the treatment of the cognitive impairment in patients with schizophrenia.
    


Intervention name(s): MK0249; Comparator: Placebo (unspecified)
Intervention type(s): Drug; Drug
Intervention description(s): MK0249 10mg (2 x 5 mg) tablet daily (qd) for 28 days.; MK0249 10mg (2 x 5 mg) Pbo tablet qd for a 28 day treatment period.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Undifferentiated schizophrenia; residual schizophrenia
A Study To Assess The Safety And Tolerability Of Different Doses Of PF-06444753 And PF-06444752 In Subjects With Allergic Rhinitis
Condition: Allergic Rhinitis
MeSH terms: Rhinitis; Rhinitis, Allergic
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to assess the safety and tolerability of different doses of
      PF-06444753 and PF-06444752 in subjects with allergic rhinitis.
    


Intervention name(s): IGE-1; IGE-2; Saline
Intervention type(s): Biological; Biological; Biological
Intervention description(s): Intramuscular, multiple dose; Intramuscular, multiple dose; Saline (0.9% sodium chloride)
Intervention MeSH terms: Immunoglobulin E
Allocation: Randomized
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Vaccines; Phase 1; Allergic Rhinitis
A Food Effect Phase I Study of the Sulfatinib in Healthy Subjects (HMPL-012)
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate to determine the effect of food on the PK of a
      single dose of 250 mg Sulfatinib and its metabolites in healthy subjects.
    

Detailed description: 
      The purpose of this study is to evaluate to determine the effect of food on the PK(
      pharmacokinetics) of a single dose of 250 mg Sulfatinib and its metabolites in healthy
      subjects and to assess the safety and tolerability of single doses of 250mg in healthy
      subjects.This study will be an open-label, randomized, two-period, crossover PK food effect
      study of Sulfatinib administered orally at 250 mg. Subjects will be screened for eligibility
      up to 14 days prior to entry into the study,there will be 2 treatments,2 weeks follow-up.
    

Intervention name(s): Sulfatinib
Intervention type(s): Drug
Intervention description(s): 250mg Sulfatinib ,single dose,oral
Other intervention name(s): HMPL-012
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Subjects
A Study to Evaluate the Long-term Safety of Arbaclofen Extended-Release Tablets for Patients With Spasticity Due to MS
Condition: Multiple Sclerosis; Spasticity, Muscle
MeSH terms: Muscle Spasticity; Multiple Sclerosis; Sclerosis
Study type: Interventional
Phase: Phase 3

Summary: 
      Spasticity is a common complication in MS and occurs in up to 84% of patients. The main sign
      of spasticity is resistance to passive limb movement characterized by increased resistance to
      stretching, clonus, and exaggerated deep reflexes. Osmotica Pharmaceutical is currently
      developing arbaclofen extended-release tablets (AERT) for the treatment of spasticity in
      patients with MS.
    

Detailed description: 
      This is a multicenter, open-label, long-term extension study to evaluate the safety and
      tolerability of oral AERT in patients with spasticity due to MS. Subjects from the double
      blind study (Study OS440-3004) may rollover into this open-label extension study, as well as
      de novo subjects. The maintenance dose will be 80 mg/day or the highest tolerated dose. Once
      the subject has reached the maintenance dose, they will remain on that dose for approximately
      1 year.
    

Intervention name(s): Arbaclofen
Intervention type(s): Drug
Intervention description(s): Arbaclofen is the active R enantiomer of baclofen.
Other intervention name(s): AERT
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Gabapentin Versus Estrogen for the Treatment of Hot Flashes
Condition: Hot Flashes
MeSH terms: Hot Flashes
Study type: Interventional
Phase: Phase 4

Summary: 
      To compare the efficacy and safety of gabapentin, estrogen and placebo in the treatment of
      hot flashes and other climacteric symptoms.
    

Detailed description: 
      HRT is associated with an increased risk of thrombo-embolic events, breast cancer and
      cardiovascular events. Safe, effective, and well-tolerated alternative therapies for hot
      flashes are needed. Gabapentin is a gamma-aminobutyric acid (GABA)-analog that we have
      reported is associated with a reduction in the frequency of hot flashes in postmenopausal
      women who were taking gabapentin for other indications. However, it is not known whether the
      efficacy of gabapentin in the treatment of hot flashes and other menopausal symptoms is
      comparable to that of estrogen, the gold standard. For this study, 60 subjects are to be
      recruited and randomized into 3 arms of 20 each (gabapentin, estrogen and placebo).We will
      perform an analysis of the results after all 60 subjects have been recruited, screened,
      enrolled and completed the study. The investigators of the study continue to be blinded to
      the study groups and their randomization. To determine if gabapentin approaches the efficacy
      of estrogen in the treatment of hot flashes,postmenopausal women between ages 35 and 60 with
      7-20 moderate-severe postmenopausal hot flashes/day will be randomized into a double-blinded
      placebo controlled trial of estrogen, gabapentin and placebo. All patients must meet
      stringent inclusion and exclusion criteria. Pre- and post-study hot flash diaries, depression
      and climacteria scales will be collected. Patients are required to undergo physical
      examination and blood work and to complete a daily hot flash and medication compliance
      records. Hot flash frequency and composite score for hot flashes will be calculated for the
      three groups based on the hot flash diary. Side effects, climacteric scale and depression
      scales will also be used.
    

Intervention name(s): Gabapentin, Estrogen and placebo administration
Intervention type(s): Drug
Intervention MeSH terms: Gabapentin; Estrogens
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Hot flashes; postmenopausal; climacteric symptoms; hormone replacement therapy; gabapentin
Can a Nasal Decongestant Test Predict Treatment Outcomes in Seasonal Allergic Rhinitis?
Condition: Seasonal Allergic Rhinitis
MeSH terms: Rhinitis; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal
Study type: Interventional

Summary: 
      We hypothesize that those patients with purely seasonal allergic rhinitis will decongest
      better than those subjects with another cause contributing to their symptoms. These latter
      patients will not improve as well on an intranasal steroid as those who decongest well,
      potentially explaining the 60% response rate in prior studies.
    


Intervention name(s): mometasone furoate nasal spray; placebo
Intervention type(s): Drug; Drug
Intervention description(s): 2 puffs in each nostril once a day for 2 weeks; 2 puffs in each nostril once a day for 2 weeks
Other intervention name(s): Nasonex; placebo comparator for Nasonex
Intervention MeSH terms: Mometasone Furoate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Reliability and Validity of Thai Calgary Depression Scale of Schizophrenia (CDSS)
Condition: Depression
MeSH terms: Depression; Depressive Disorder; Schizophrenia
Study type: Observational

Summary: 
      Depression in patients with schizophrenia is common. Several factors was found to be
      associated with depression including medical illness, quality of life, positive symptoms, and
      typical antipsychotics. The Calgary depression scale of schizophrenia (CDSS) is commonly used
      for screening depression in schizophrenia,however; the Thai version of CDSS has not been
      validated.

      This study aims to a.) test the reliability and validity of the Thai version of Calgary
      depression scale of schizophrenia (CDSS) and b.) identify the prevalence and factors
      associated with depression in patients with schizophrenia including quality of life, type of
      antipsychotic drugs, and severity of schizophrenia in 60 patients with schizophrenia at the
      Faculty of Medicine, Chiang Mai University, Thailand.
    

Detailed description: 
      Measurements:

      The Thai version of Calgary depression scale of schizophrenia (CDSS), Positive and Negative
      Syndrome Scale (PANSS), Hamilton Rating Scale for Depression-17 (HAM-D 17), Montgomery-Asberg
      Depression Rating Scale (MADRS), the Thai abbreviated version of World Health Organization
      quality of life (WHOQOL-BREF-THAI).
    

Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Pariticipants diagnosed with schizophrenia according to DSM-IV-TR.
      
Keywords: Depression; Schizophrenia
Single Rising Dose Study of BI 655088 Administered Intravenously in Healthy Male Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      Investigation of safety and tolerability of BI 655088 following intravenous infusion of
      single rising doses and exploration of the pharmacokinetics and pharmacodynamics of BI 655088
      after single dosing
    


Intervention name(s): BI 655088; Placebo
Intervention type(s): Drug; Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Triathlon® Cruciate Retaining (CR) Total Knee System Outcomes Study
Condition: Arthroplasty, Replacement, Knee
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the clinical outcomes (range of motion, pain,
      function, radiographic stability, and health related quality of life) of patients receiving
      the Triathlon® Cruciate Retaining (CR) Total Knee System. These outcomes will be evaluated by
      comparing pre-operative to post-operative scores, as well as to a control group. The control
      group is the Scorpio® CR Total Knee System.
    

Detailed description: 
      The Triathlon® Cruciate Retaining (CR) Total Knee System components are for use in cemented
      total knee arthroplasty for painful, disabling joint disease of the knee resulting from
      non-inflammatory degenerative joint disease (including osteoarthritis, traumatic arthritis or
      avascular necrosis) or rheumatoid arthritis (excluded from this study according to protocol).
      The components are designed to improve range of motion (ROM) and stability. This study serves
      to demonstrate that subjects have reduced pain, increased ROM and improved stability
      following implantation with the Triathlon Cruciate Retaining (CR) Total Knee System as
      compared to the historical control.
    

Intervention name(s): Triathlon® CR Total Knee System
Intervention type(s): Device
Intervention description(s): The purpose is to evaluate the Triathlon® CR Total Knee System.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Comparisom of Liquid Nitrogen and Vitamin D3 in The Treatment of Cutaneous Warts
Condition: Cutaneous Warts
MeSH terms: Warts
Study type: Interventional
Phase: Phase 1

Summary: 
      A total of 60 female patients (30 patients in each group) with cutaneious warts diagnosed by
      a consultant dermatologist on physical examination were included in this study.

      In Group A patients were subjected to liquid nitrogen cryotherapy (-196 0C) while patients in
      Group B were subjected to vitamin D3 (5mg/ml) for 3 sessions at every 3 weeks interval.
      Effectiveness in both groups was ascertained in terms of > 50% reduction in wart size by an
      expert dermatologist on physical examination at the end of third session. Patients were
      followed for further 6 weeks after last session to look for any sort of recurrence and
      remission.
    


Intervention name(s): liq nitrogen; intralesional vitamin D3
Intervention type(s): Drug; Drug
Intervention description(s): In Group A patients were subjected to liquid nitrogen cryotherapy (-196 0C) for 3 sessions at every 3 weeks interval. Effectiveness in was ascertained in terms of > 50% reduction in wart size by an expert dermatologist on physical examination at the end of third session. Patients were followed for further 6 weeks after last session to look for any sort of recurrence and remission.; Group B were subjected to vitamin D3 (5mg/ml) for 3 sessions at every 3 weeks interval. Effectiveness was ascertained in terms of > 50% reduction in wart size by an expert dermatologist on physical examination at the end of third session. Patients were followed for further 6 weeks after last session to look for any sort of recurrence and remission.
Other intervention name(s): cryotherapy
Intervention MeSH terms: Vitamin D; Cholecalciferol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Effectiveness of Insignia ™ Versus Standard Orthodontic Treatment With Damon Q Brackets
Condition: Orthodontic Treatment; Fixed Appliances; Insignia; DamonQ Brackets
Study type: Interventional

Summary: 
      The hypotheses tested in this study are: There is a statistical significant difference, in
      treatment duration and result of treatment in cases treated using traditional Damon Q
      brackets or using Insignia.
    


Intervention name(s): Damon self ligating orthodontic bracket; Insignia self ligating orthodontic bracket
Intervention type(s): Device; Device
Intervention description(s): Orthodontic treatment with Damon self ligating bracket; Orthodontic treatment with Insignia self ligating bracket
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Compare treatment between two appliance systems
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
The Incidence of the Intravascular Injection During S1 Transforaminal Epidural Steroid Injection in Two Approaches: Medial vs Lateral in Anteroposterior View
Condition: Lumbosacral Radicular Pain
Study type: Interventional

Summary: 
      Lumbosacral transforaminal epidural steroid injection (TFESI) is helpful for the treatment of
      lumbosacral radicular pain, but in case of intravascular injection, infrequently serious
      complication can be developed. Against this backdrop, if there is any difference of frequency
      of intravascular injection incidence during S1 (sacrum 1) TFESI between method using medial
      approach and method using lateral approach in anteroposterior view, the result can be crucial
      factor in selecting the approach. In addition, appropriate volume of injection will be
      checked in each approach.
    


Intervention name(s): S1 transforaminal epidural steroid(dexamethasone) injection
Intervention type(s): Drug
Intervention description(s): medial approach group (n=85): check intravascular injection while performing S1 transforaminal epidural steroid(dexamethasone) injection in medial side of S1 foramen under fluoroscopy
lateral approach group (n=85): same as medial approach group except using lateral side of S1 foramen
Intervention MeSH terms: Dexamethasone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Correction of Vitamin D Deficiency and Its Effect on Ovulation Induction in Women With PCOS (VIDEO): A Feasibility RCT
Condition: PCOS
MeSH terms: Vitamin D Deficiency
Study type: Interventional
Phase: Phase 2

Summary: 
      Recently, a special emphasis has recently been directed to the potential role of vitamin D
      and some regulatory peptides (e.g. adipokines and follistatin) and their associated metabolic
      roles and genetic factors in the development of PCOS and its related co-morbidities. The aim
      of this study was to assess the feasibility of conducting a pragmatic RCT assessing the
      effectiveness of adopting a protocol of screening for and correcting Vitamin D deficiency in
      women with PCOS seeking fertility treatment in a low/middle income care (LMIC) setting
    

Detailed description: 
      Research question:

      In PCOS patients, is there any effect of vitamin D testing and correction on ovulation
      induction in women with PCOS?

      Research hypothesis:

      There is effect of testing and correcting vitamin D status as regard ovulation in patients
      with PCOS
    

Intervention name(s): Vitamin D; Ovulatory Agent
Intervention type(s): Drug; Drug
Intervention description(s): 6000 IU of vitamin D3; only Clomophine Citrate
Other intervention name(s): Vidrop®, Medical Union Pharmaceuticals, Egypt; Clomiphene Citrate for induction of ovulation
Intervention MeSH terms: Vitamin D; Clomiphene
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: PCOS, vitamin D
Effects of Regular Exercise on Adult Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional

Summary: 
      The purpose of this study is to assess the effects of regular exercise on physical fitness,
      asthma control, and quality of life among adult asthmatics.
    


Intervention name(s): Exercise
Intervention type(s): Other
Intervention description(s): The exercise group is given a 24-week individualized training program, including aerobic exercise, muscular training, relaxation exercises and stretching. Patients are asked to observe their asthma control daily and to mark in their diary asthma symptoms and activity limitations as well as duration, intensity and form of exercising on daily basis. They are also asked to perform PEF-measurements twice a day for one-week period every 4 weeks. The control group receives ordinary instructions.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Asthma; Exercise; Asthma control; Physical fitness; Quality of life
Uric Acid Study in Healthy Male Volunteers
Condition: Gout; Coronary Artery Disease
MeSH terms: Coronary Artery Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is being conducted to examine the effect of AZD6140 on the levels of certain
      chemicals in subjects' blood and urine.
    


Intervention name(s): AZD6140; Placebo to match AZD6140
Intervention type(s): Drug; Drug
Intervention description(s): Oral tablets taken bid for 5 days; Oral tablets taken bid for 5 days
Intervention MeSH terms: Ticagrelor
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: Uric; Acid; Level