bioihbjkbjnl/mcl2 huggingface dataset:
Motor Learning of a Planning Task in Stroke Patients: the Maze Paradigm Measured Through Time and Error as Variables
Condition: Stroke
MeSH terms: Stroke
Study type: Observational

Summary: 
      The purpose of this study is to investigate the process of acquiring a motor skill subject in
      post-stroke, comparing them with healthy subjects.
    

Detailed description: 
      20 post-stroke patients were comprised to the experimental group (EG) and 20 health subjects
      were included to the control group (CG. Inclusion criteria: chronic stroke, single stroke
      event, lesion in anterior circulation, right handed subjects, MEEM over 23 points. The task
      consisted in a maze paradigm, made by pencil and paper, with the non affected side for EG and
      left upper extremity for CG. The instruction was given to the subjects to complete the task
      as fast as possible. The study consisted in three phases: acquisition (AQ)with 30 trials,
      transfer (TR, short retention (R1)and long term retention (R2 both with 5 trials.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        patients after stroke
      
Biospecimen description: 
      no biospecimens are to be retained
Is Patients With Pulmonary Disease Benefit a Program With Yogic Exercises?
Condition: COPD; Asthma
Study type: Interventional

Summary: 
      Is Yogic Exercises (12 weeks) increasing respiratory function, functional capacity and
      quality of life in patients with obstructive lung diseases. With follow up after 6 months.
    

Detailed description: 
      Is Yogic Exercises increasing respiratory function in patients with obstructive lung
      diseases. Will YE improve respiratory muscle strength, functional capacity, inspiratory and
      expiratory pressure, lung function, perceived dyspnea, dyspnea-related distress (DD), less
      frequency of dyspnea and heart rate variability in patients with pulmonary disease.
      Qualitative content analysis will be performed on approximately 15 interviews with patients
      participated in the yoga group about their experiences and their benefits
      perceived/experienced of the yogic exercises

      We want to try YE as an alternative treatment in patients with mild to severe pulmonary
      disease.
    

Intervention name(s): Yogic exercises; Physiotherapy
Intervention type(s): Other; Other
Intervention description(s): Yogic exercises (YE) - 2 hours per week, 1h in each session; Physiotherapy (low intensity cardiovascular training and strength training) - 2 hours per week, 1 h in each session
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Effect of KMC on Neurobehavior of Preterm Neonates
Condition: Neonatal Neurobehavior
Study type: Interventional

Summary: 
      This prospective cohort study was conducted on stable preterm infants (31 to 35 weeks
      gestation). Neonates were subjected to either daily KMC for 60 minutes, daily KMC for 120
      minutes or conventional care (controls) for at least 7 days. Neonates were evaluated by
      Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) at 36 weeks gestation.
      Salivary cortisol was measured before and after first KMC session and after 7 days.
    


Intervention name(s): KMC
Intervention type(s): Behavioral
Intervention description(s): Neonates were subjected to either daily KMC for 60 minutes, daily KMC for 120 minutes or conventional care (controls) for at least 7 days.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
A Study of the Safety and Efficacy of Anacetrapib (MK-0859) When Added to Ongoing Statin Therapy (MK-0859-021)
Condition: Hypercholesterolemia
MeSH terms: Hypercholesterolemia
Study type: Interventional
Phase: Phase 3

Summary: 
      This study will evaluate the effects of 2 different dose levels of anacetrapib on low-density
      lipoprotein-cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) in
      participants with hypercholesterolemia when added to an existing statin-modifying therapy.
    


Intervention name(s): Anacetrapib 100 mg; Placebo for anacetrapib 100 mg; Anacetrapib 25 mg; Placebo for anacetrapib 25 mg
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): 100 mg tablet, oral, once daily for 24 weeks; Placebo tablet, orally, once daily for 24 weeks; 25 mg tablet, oral, once daily for 24 weeks; Placebo tablet, orally, once daily for 24 weeks
Other intervention name(s): MK-0859; MK-0859
Intervention MeSH terms: Oxazolidinones; Anacetrapib
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Cardiac Arrhythmias in Epilepsy: the CARELINK-study
Condition: Epilepsy; Asystole; Cardiac Arrhythmias
MeSH terms: Epilepsy; Arrhythmias, Cardiac
Study type: Interventional

Summary: 
      Patients with difficult-to-treat epilepsy ("refractory epilepsy") are at high risk of sudden
      death: sudden unexpected death in epilepsy (SUDEP). Cardiac arrhythmias are one of the
      possible causes of SUDEP. When monitoring in the hospital setting, the frequency of cardiac
      arrhythmias in people with epilepsy is low: 0,4%. However, when a subcutaneous implantable
      device (Reveal XT) is used to monitor heart rhythm continuously for an extended period of
      time, the frequency of clinically relevant arrhythmias appeared much higher in two small
      observational studies (n=19): 6-20%. The aim of this study is to analyze the frequency and
      underlying mechanism of cardiac arrhythmias in a larger group of 50 people with refractory
      epilepsy with Reveal XT. In the future, this may help us to identify those epilepsy patients
      at high risk of cardiac arrhythmias, so that we can timely institute preventive measures
      (e.g. pacemaker implantation).
    


Intervention name(s): implantable heart rate monitor
Intervention type(s): Device
Intervention description(s): Implantation of Reveal XT
Other intervention name(s): Reveal XT
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Lateral Neck Sentinel Lymph Node Biopsy(LSLNB)in PTC
Condition: Thyroid Neoplasm
MeSH terms: Thyroid Neoplasms
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      Objective: To investigate the incidence of lateral neck node occult metastasis and to show
      the usefulness of sentinel lymph node biopsy (SLNB) in the detection of lateral neck node
      metastasis in thyroid carcinoma, the investigators used a radioisotope to detect the sentinel
      lymph node.

      Summary Background Data: Although occult lymph node metastasis to the lateral neck
      compartment is common in papillary thyroid carcinoma, the incidence and patterns of lateral
      neck node metastasis in papillary carcinoma are not known.
    

Detailed description: 
      On the day of the operation, patients underwent preoperative lymphoscintigraphy after the
      intratumoral injection of a Tc-99m phytate 1 mCi in 0.1-0.2 mL 0.9% NaCl under
      ultrasonographic guidance. Total thyroidectomy or lobectomy with central neck dissection
      preceded SLN detection to avoid interference by primary tumor radioactivity. After total
      thyroidectomy or lobectomy, the dissections were performed toward the internal jugular chain
      beneath the sternocleidomastoid muscle. A handheld, collimated gamma probe and
      lymphoscintigraphy were used to scan the lateral compartments (through skin and under the
      SCM) for "radioactive" lymph nodes. Removed SLNs were submitted immediately for frozen
      biopsy. If any of the SLNs were positive for metastasis on the frozen sections, MRND was
      performed immediately. In cases for which the frozen section was negative but the final
      pathology report detailed microscopic positivity in the lateral sentinel nodes, RAI ablations
      were performed without additional MRND.
    

Intervention name(s): Lateral sentinel lymph node biopsy
Intervention type(s): Procedure
Intervention description(s): Sentinel lymph node biopsy with radioisotope. Isotope injection and lymphoscintigraphy preoperatively
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Vitamin C Supplementation Intervention
Condition: Heart Failure
MeSH terms: Heart Failure
Study type: Interventional

Summary: 
      This study is to test a low-cost, simple vitamin C supplementation intervention, that is,
      comparing placebo to 500 mg/day vitamin C and 1 gram/day vitamin C daily to assess
      feasibility and acceptability of vitamin C supplementation and effects on serum vitamin C
      level, health-related quality of life (HRQOL), symptom burden, oxidative stress, and cardiac
      function.
    

Detailed description: 
      This study will address feasibility from the perspective of being able to: a) to detect
      significant differences in the serum vitamin C level after supplementation (3 months) between
      the intervention groups and the control group, b) to detect significant differences in health
      related quality of life (HRQOL), symptom burden, oxidative stress, and cardiac function after
      vitamin C supplementation (3 months) between the intervention groups and the control group.
    

Intervention name(s): Vitamin C 500 mg; Vitamin C 1000 mg; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement; Other
Intervention description(s): 500 mg tablet taken orally with one meal daily; 1000 mg tablet taken orally with one meal daily; 1 tablet taken orally with one meal daily
Other intervention name(s): L-Ascorbic acid; L-Ascorbic acid; Sugar pill
Intervention MeSH terms: Vitamins; Ascorbic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: Vitamin C supplementation
Controlled Clinical Study to Determine Novel Health Benefits of Cheese Consumption
Condition: Metabolic Syndrome X
MeSH terms: Metabolic Syndrome; Syndrome
Study type: Interventional

Summary: 
      To determine the effects of high cheese diets varying in carbohydrate content on markers of
      disease risk.
    

Detailed description: 
      Summary of Proposed Research:

      This project will involve four controlled 4 wk feeding periods in individuals with metabolic
      syndrome (currently 1/3 of US adults). After a 2 wk run-in period, 20 subjects will be fed
      one of three diets in a randomized and balanced order: a typical American High-Carb diet high
      in cheese (6 oz/day), a High-Carb diet low in cheese (0 oz/day), or a Moderate-Carb,
      high-cheese diet (6 oz/day), Low-Carb, high cheese where cheese displaces an isocaloric
      amount of carbohydrate. There will be a 2 wk washout period separating trials during which
      subjects consume their normal diet. Specific menus will be designed for each feeding phase
      and all food will be prepared for subjects. Testing will occur at baseline and after each
      feeding period. Measures of cholesterol beyond standard LDL- and HDL-cholesterol will be done
      by examining lipoprotein particle size, apolipoproteins, and fatty acid composition [i.e.,
      accumulation of saturated fat in blood and tissues, palmitoleic acid (highly linked to
      cardiovascular disease), and detection of phytanic acid (a uniquely bioactive fatty acid in
      dairy fat)]. Changes in whole body and regional fat, including measures of visceral fat and
      liver fat, will be examined non-invasively by dual-energy X-ray absorptiometry (DXA) and
      magnetic resonance imaging (MRI).
    

Intervention name(s): Nutritional and Dietary Manipulation
Intervention type(s): Other
Intervention description(s): Participants will undertake a controlled feeding intervention. All food will be prepared and delivered to participants by research staff. Participants will be asked to exclusively eat what is provided to them in efforts to control any dietary effects.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Diet Intervention; Metabolic Syndrome; Feeding Study; Prediabetes
Use of ΔIVC for Early Diagnosis of AHF in AECOPD
Condition: Acute Decompensated Heart Failure; COPD Exacerbation
MeSH terms: Heart Failure
Study type: Observational

Summary: 
      Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive
      pulmonary disease (AECOPD).

      This association is frequently underestimated with regard to the difficulty of clinical
      diagnosis.

      The investigators expect that the application of the inferior vena cava collapsibility index
      (ΔIVC)could be useful in this issue.
    

Detailed description: 
      Acute heart failure (AHF) is a common cause of COPD exacerbation however its role is very
      often underestimated. Until now, the use of echocardiography and some invasive hemodynamic
      exploration techniques such as the Swanganz catheter has been stated as reference. Other
      noninvasive diagnostic methods have been studied, such as systolic time intervals and
      Valsalva maneuver, but their application still difficult in patients with COPD exacerbation,
      especially in emergency department (ED) settings. the study aimed to evaluate the performance
      of a new diagnostic technique based on the measurement of the ΔIVC for the early
      identification of AHF in patients presenting to the ED with acute COPD exacerbation.
    

Intervention name(s): calculation of the inferior vena cava collapsibility index
Intervention type(s): Diagnostic Test
Intervention description(s): the ΔIVC was calculated by the emergency physician who was blinded from the patient's medical history using the formula ((IVCmax-IVCmin)/IVCmax) X100.A cutoff of 15% was used to define the presence(<15%) or absence(>15%) of heart failure
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        patients with history of COPD admitted to the emergency departmet for AECOPD and stable
        hemodynamic status
      
Keywords: COPD; Acute Heart Failure; Inferior vena cava; Ultrasound; Collapsibility index
CV Disease in Adolescents With Type 2 Diabetes
Condition: Cardiovascular Diseases; Diabetes Mellitus; Heart Diseases; Obesity
MeSH terms: Cardiovascular Diseases; Heart Diseases; Diabetes Mellitus
Study type: Observational

Summary: 
      To study cardiac and vascular structure and function in a population of adolescents with type
      2 diabetes mellitus (T2DM) compared to a similar group with obesity alone and a similar
      non-obese group.
    

Detailed description: 
      BACKGROUND:

      The prevalence of type 2 diabetes mellitus has increased dramatically in adolescents. This
      appears to be a direct result of the increase in prevalence and severity of obesity in the
      pediatric population. In adults with type 2 diabetes, it is well known that the risk for
      cardiovascular disease (CVD) is quite high. This has led to current clinical recommendation
      that adults with diabetes be considered equivalent in risk to those adults who already have
      existing coronary artery disease. It is not known if adolescents with type 2 diabetes have an
      equivalent high level of risk of CVD as the adult population. If they do then it would be
      expected that they would develop clinical CVD in their late 20's or 30's. This would have
      important clinical implications and would suggest the need for very aggressive management of
      CVD risk factors and diabetes.

      DESIGN NARRATIVE:

      The study is a cross-sectional evaluation of cardiac and vascular structure and function in a
      population of adolescents with type 2 diabetes compared to a group with similar age, sex,
      race and BMI with obesity alone and a non obese group with similar age, sex and race. 300
      subjects with type 2 diabetes, 300 subjects with obesity and 300 non obese subjects will be
      studied. Assessment of CVD development will be accomplished using novel non invasive imaging
      methods for subclinical atherosclerosis including echocardiographic measurement of cardiac
      structure and function, ultrasound evaluation of carotid intimal medial thickness, and
      evaluation of endothelial function by brachial artery reactivity. The primary hypothesis is
      that adolescents with type 2 diabetes will have greater abnormality in cardiac and vascular
      structure and function compared to controls with obesity. Subjects with obesity alone will
      have greater abnormality in cardiac and vascular structure and function compared to controls
      who are not obese. Correlates of cardiac and vascular abnormalities including markers of
      inflammation, adiponectin, diet and physical activity will also be evaluated.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Three groups of adolescents:

          1. Lean controls

          2. Obese controls (without diabetes)

          3. Obese with diabetes
A Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes With Inadequately Controlled Hypertension on an ACEI or ARB and an Additional Antihypertensive Medication
Condition: Type 2 Diabetes
MeSH terms: Hypertension; Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to learn if BMS-512148 (Dapagliflozin), after 12 weeks, can
      improve (decrease) blood pressure in patients with type 2 diabetes with uncontrolled
      hypertension who are on an Angiotensin-converting enzyme inhibitor (ACEI) or an Angiotensin
      Receptor Blocker (ARB).The safety of this treatment will also be studied
    


Intervention name(s): Dapagliflozin; Placebo matching Dapagliflozin
Intervention type(s): Drug; Drug
Intervention description(s): Tablets, Oral, 10 mg, once daily, Up to 12 weeks; Tablets, Oral, 0 mg, once daily, Up to 12 weeks
Other intervention name(s): BMS-512148; Farxiga™
Intervention MeSH terms: Dapagliflozin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Diabetes Mellitus, Type 2; Diabetes Mellitus; Endocrine System Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Angiotensin Receptor Inhibitors; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Cardiovascular Agents; Pharmacological Actions
Combine Serratus Anterior Plane Block Versus Erector Spinae Plane Block in Coronary Bypass Surgery
Condition: Cardiac Surgery; Postoperative Pain; Regional Anesthesia Morbidity
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      Even though Erector Spinae Plane (ESP) Block is shown to be efficient in cardiac surgery, the
      Combine Serratus Anterior Plane (CSAP) Block is still controversial if it has an efficient
      analgesic effect for sternotomy and drain tube pain relief. This study aims to compare ESP
      block and CSAP block for postoperative analgesia in coronary bypass surgery patients.
    

Detailed description: 
      Acute postoperative pain after cardiac surgery originates various surgical procedures that
      may cause pain including the incision of tissues, sternotomy, the separation of bone-joint
      structures, the severity and duration of these applications, the use of chest tubes, and the
      patient's personal inflammatory may affect the response to these stimuli. Postoperative pain
      is a critical risk factor for the development of pulmonary and cardiovascular complications
      such as atelectasis, cardiac ischemia, and arrhythmias. Researchers claim that adding
      techniques to iv drugs, such as thoracic epidural anesthesia, paravertebral block, or erector
      spinae plane block (ESP) to multimodal analgesia regimens positively affect recovery.
      Although the efficacy of ESP block in providing postoperative analgesia has been demonstrated
      in many studies, there is no study comparing CSAP and ESP block in cardiac surgery.
    

Intervention name(s): ESP block; CASP block
Intervention type(s): Procedure; Procedure
Intervention description(s): Preoperative, awake, bilateral, ultrasound-guided erector spinae plane block with 30 mL 0.25 % bupivacaine; Preoperative, awake, bilateral, ultrasound-guided combine serratus anterior plane block with 30 mL 0.25 % bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: erector spinae plane block; combined serratus anterior plane block; sternotomy
Transversus Abdominis Plane Block Versus Paravertebral Block for Post Operative Pain Relief in Open Renal Surgeries
Condition: Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      Pain relief after renal surgeries is essential as it may lead to reduction in the incidence
      of many post operative complications .

      There are a lot of regional anesthetic techniques to provide analgesia postoperatively as
      paravertebral block (PVB) and transversus abdominis plane (TAP) block.

      TAP block has been used to provide postoperative analgesia in a lot of abdominal surgeries
      including upper abdominal surgeries.It is safer technique than PVB, but the effectiveness of
      TAP block is unknown in comparison with PVB in post operative analgesia after renal surgeries
      .
    

Detailed description: 
      Pain relief after renal surgeries is essential as it may lead to reduction in the incidence
      of post operative respiratory complications . A lot of patients presented to these operations
      may have comorbidities as impaired renal function and respiratory problems , conditions like
      these may contraindicate aministration of systemic analgesia as opioids .

      There are a lot of techniques to provide analgesia postoperatively as paravertebral block
      (PVB) and transversus abdominis plane (TAP) block .

      Paravertebral block is effective technique for post operative analgesia for upper abdominal
      surgeries , but it may be associated with some complications as : pneumothorax , spread of
      local anesthetic to the epidural space and paravertebral blood vessels , and this may lead to
      systemic toxicity of local anesthetic .

      TAP block has been used to provide postoperative analgesia in a lot of abdominal surgeries
      including upper abdominal surgeries , but it is safer technique than PVB , but the
      effectiveness of TAP block is unknown in comparison with PVB in post operative analgesia
      after renal surgeries .
    

Intervention name(s): Thoracic paravertebral block; Transversus abdominis plane block
Intervention type(s): Procedure; Procedure
Intervention description(s): Thoracic paravertebral block is a technique in which , the local anesthetic agent is injected in the paravertebral space to anesthetise the spinal nerves after emerging from the vertebral canal in order to provide analgesia in the thoracic and upper abdominal area .; Transversus abdominis plane block is a technique is mostly done under ultrasound guidance to identify the transversus plane between the internal oblique muscle and the transverses abdominis muscle , the space in which the neurovascular supply of the anterior abdominal wall is present , and hence the injection of local anesthetic agent in this space results in anesthesia of the anterolateral aspect of the abdominal wall.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment