bioihbjkbjnl/mcl2 huggingface dataset:
Bipolar Disorder in Late Life
Condition: Bipolar Disorder
MeSH terms: Bipolar Disorder
Study type: Observational

Summary: 
      The purpose of this study is to look at certain structural changes in the brain in people
      with bipolar disorder or those with a history of Bipolar disorder.
    

Detailed description: 
      Individuals with bipolar disorder or those with a history of bipolar disorder may have
      certain structural changes in their brain. The purpose of this study is to look at those
      changes, as well as the assessment of risk factors for bipolar disorders, involving both
      social and psychological aspects of behavior, age, education, marital relations, nutrition,
      physical activity, etc., compared with persons not having bipolar disorder. These changes in
      the brain will be measured by Magnetic Resonance Imaging (MRI).
    

Intervention name(s): Valproic Acid
Intervention type(s): Drug
Intervention description(s): Tablets, 250mg-3000mg
Other intervention name(s): Depakote
Intervention MeSH terms: Valproic Acid
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Subjects recruited from the adult inpatient and outpatient psychiatric clinics at Duke
        University Medical Center and John Umstead Hospital (Butner, NC).
      
Biospecimen description: 
      DNA collected for genetic databank.
    
Keywords: BPD
Effect of Hyaluronic Acid in the Treatment of Periodontal Pockets
Condition: Chronic Periodontitis With Infra-bony Defects
MeSH terms: Periodontitis; Chronic Periodontitis
Study type: Interventional

Summary: 
      The aim of this study is to evaluate the effect of hyaluronic acid in the surgical treatment
      of periodontal pockets in people with gum disease.

      This research consists of clinical and radiographic studies. Participants should have
      symmetric periodontal pockets in the upper or lower jaw.

      Participants will be treated surgically using hyaluronic acid on one side of the jaw.

      Clinical indexes and radiographic cone-beam computed tomographic (CBCT) images will be taken
      for each participant before surgical treatment and 12 months after surgical treatment.
    

Detailed description: 
      The aim of this study is to evaluate the effect of hyaluronic acid in the surgical treatment
      of infra-bony pockets in chronic periodontitis patients.

      This research consists of clinical and radiographic studies.

      1- The clinical study: is a randomized controlled trial with a split mouth technique.

      Chronic periodontitis patients with Infra-bony pockets will be collected from the Department
      of Periodontics in faculty of dentistry - Damascus university.

      Participants should have symmetric infra-bony pockets in the upper or lower premolar area
      with pocket probing depth more than 6 mm.

      Participants will be treated surgically using open flap curettage.

      Open flap curettage will be done for each patient in both sides of the jaw, but hyaluronic
      acid will be used in one of the two sides with random allocation of the site that in going to
      be treated with hyaluronic acid.

      Plaque index, gingival index, bleeding on probing, tooth mobility index, pocket probing depth
      and clinical attachment loss will be taken for each participant four times; before surgical
      treatment, 3 months, six months and 12 months after surgical treatment.

      Radiographic study: will be done using CBCT radiography technique. CBCT will be taken for
      each participant before and after 12 months of surgical treatment. Different distances,
      vertical bone fill and depth of infra-bony defect will be measured on CBCT images.
    

Intervention name(s): Hyaluronic Acid
Intervention type(s): Drug
Intervention description(s): This material will be used in conjunction with the ordinary surgical procedure
Intervention MeSH terms: Hyaluronic Acid
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Hyaluronic acid; infra-bony defects; chronic periodontitis; experimental; radiographic; clinical; periodontal surgical treatment; open flap curettage
Survey of Thai-Muslim Health Status
Condition: Diabetes; Hypertension; Hyperlipidemia
MeSH terms: Hypertension; Hyperlipidemias; Hyperlipoproteinemias
Study type: Observational

Summary: 
      The purpose of this study was to determine the prevalence and risk factors of diabetes,
      hypertension, hyperlipidemia among Thai muslim population aged 35-75 years.
    

Detailed description: 
      This was a cross-sectional study conducted in Bangkok and surrounding provinces.
      Approximately 1500 participants were enrolled. Study staff interviewed participants on basic
      demographic data, health status, physical activities, food frequency and 24-hour recall.
      Anthropometry (body weight, height, hip and waist circumference) and physical assessment
      (blood pressure)were measured. Ten milliliters of venous blood was drawn by venipuncture
      after a 12 h overnight fast for determination of fasting plasma glucose (FPG) and blood lipid
      concentrations (total cholesterol, triglyceride, and HDL-cholesterol). FPG was measured by
      the enzymatic colorimetric method with glucose oxidase.21 Total cholesterol was determined by
      the cholesterol oxidase method and serum triglycerides concentration was determined by
      standardized enzymatic procedures using glycerol phosphate oxidase assay.22, 23 HDL-
      cholesterol was measured by enzymatic assays.24 LDL cholesterol was calculated according to
      the method of Friedwald et al.25 All samples were analyzed when internal quality control met
      the acceptable criteria. Intra-and inter-assay CVs were 2.01% and 3.01% for FPG, 1.87% and
      4.24% for total cholesterol, 0.93% and 11.6% for triacylglycerols, and 0.99% and 1.49% for
      HDL cholesterol, respectively.
    

Intervention name(s): No intervention
Intervention type(s): Other
Intervention description(s): No intervention
Observational model: Ecologic or Community
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Thai muslim residents in 4 muslim communities in and around Bangkok.
      
Biospecimen description: 
      Blood serum
    
Keywords: Thai-muslim; Thai-HALAL; Diabetes; Hypertension; Hyperlipidemia; Metabolic syndrome
To Assess the Drug-drug Interaction Potential Between Dapivirine Vaginal Ring-004, Containing 25 mg of Dapivirine, and Clotrimazole 10 mg/g (1%)
Condition: HIV- Prevention
Study type: Interventional
Phase: Phase 1

Summary: 
      A Study to assess the drug-drug interaction potential, between Dapivirine Vaginal Ring-004,
      containing 25 MG of Dapivirine.
    

Detailed description: 
      AN OPEN-LABEL, RANDOMISED TRIAL, WITH A THREE-PERIOD CROSSOVER PART IN HEALTHY HIV-NEGATIVE
      WOMEN TO ASSESS THE DRUG-DRUG INTERACTION POTENTIAL BETWEEN DAPIVIRINE VAGINAL RING-004,
      CONTAINING 25 MG OF DAPIVIRINE, AND CLOTRIMAZOLE 10 mg/g (1%) ADMINISTERED AS A VAGINAL
      CREAM, WITH A FOLLOW-ON PERIOD TO ASSESS THE EFFECT OF MULTIPLE RING REMOVALS AND
      RE-INSERTIONS DURING THE 28-DAY PERIOD OF THE DAPIVIRINE VAGINAL RING-004 USE ON THE SYSTEMIC
      AND LOCAL EXPOSURE AND RESIDUAL AMOUNT OF DAPIVIRINE IN USED RINGS
    

Intervention name(s): Dapivirine Ring-004; Dapivirine Ring-004 for 28 days along with clotrimazole; Clotrimazole
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Treatment A: Dapivirine Ring-004 for 28 days; Treatment B: Dapivirine Ring-004 for 28 days along with clotrimazole, 5 g per day for 7 days; Treatment C: Clotrimazole, 5 g per day for 7 days
Other intervention name(s): Treatment A; Treatment B; Treatment C
Intervention MeSH terms: Dapivirine; Clotrimazole; Miconazole
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
SAD/MAD Study to Assess Safety, Tolerability, PK & PD of MEDI1814 in Subjects With Mild-Moderate Alzheimer's Disease.
Condition: Mild-Moderate Alzheimer's Disease; Healthy Elderly
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to assess the safety, drug levels and effects on the body of 1
      or 3 injections of MEDI1814, in people with mild to moderate Alzhiemer's Disease or healthy
      elderly people.
    


Intervention name(s): MEDI1814 for IV injection; MEDI1814 for Subcutaneous Injection; IV Placebo; Placebo for Subcutaneous Injection
Intervention type(s): Biological; Biological; Biological; Biological
Intervention description(s): Monoclonal antibody for IV Injection; Monoclonal antibody for subcutaneous injection; Placebo for IV injection; Subcutaneous Placebo Injection
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Basic Science
First-In-Human Intracoronary OCT-FLIm In Patients Undergoing PCI
Condition: Atherosclerosis Coronary Artery With Angina Pectoris; Atheroscleroses, Coronary; Atherosclerotic Plaque; Thin-cap fIbroatheroma; Atherosclerosis
MeSH terms: Atherosclerosis; Angina Pectoris; Coronary Artery Disease; Myocardial Ischemia; Plaque, Atherosclerotic
Study type: Interventional

Summary: 
      Patients will undergo intracoronary imaging using combined optical coherence
      tomography-fluorescence lifetime imaging (OCT-FLIm) during percutaneous coronary
      intervention, and the obtained imaging data will be used to assess the efficacy of this
      dual-modal catheter imaging strategy in characterizing high-risk plaque.
    

Detailed description: 
      Fluorescence lifetime imaging (FLIm) is a novel imaging approach allowing label-free
      biochemical characterization of atherosclerotic plaque. A combined optical coherence
      tomography (OCT) and FLIm that can provide a simultaneous structural and biochemical
      assessment of atheroma has been constructed successfully. This study sought to investigate
      whether the dual-modal intravascular OCT-FLIm is able to characterize high-risk plaques in
      patients undergoing percutaneous coronary intervention.

      Forty patients with multivessel coronary artery disease, who had at least one obstructive
      lesion (>70% diameter stenosis) that is considered suitable for PCI, will be included in the
      study. Culprit and mildly stenotic non-culprit plaques will be imaged using OCT-FLIm
      catheter.

      Six-month follow-up assessment is systematically scheduled in all patients to assess temporal
      changes in FLIm signatures according to treatment strategies (medical therapy, interventional
      therapy etc).
    

Intervention name(s): Dual-modal OCT-FLIm
Intervention type(s): Device
Intervention description(s): Intracoronary imaging using dual-modal OCT-FLIm catheter
Intervention model: Single Group Assignment
Intervention model description: Single group patient enrollment and scheduled 6-month follow-up assessment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Fluorescence lifetime imaging; High-risk coronary plaque; Optical coherence tomography; Intravascular imaging; Biochemical imaging
Computer-assisted Cognitive Rehabilitation (CACR), Placebo CACR and Psycho-stimulants in the Treatment of ADHD
Condition: Attention Deficit Disorder With Hyperactivity
MeSH terms: Hyperkinesis; Attention Deficit Disorder with Hyperactivity
Study type: Interventional
Phase: Phase 3

Summary: 
      Current research aimed to compare the efficacy of computer-assisted cognitive rehabilitation
      (CACR), stimulant drugs and Placebo CACR on executive functions and clinical symptoms of
      children with attention deficit/hyperactivity disorder (ADHD).
    

Detailed description: 
      The investigators administered a randomized controlled trial (RCT) through random assignment
      of ADHD subjects in to three different groups to compare the effects of CACR,
      immediate-release methylphenidate, and a Placebo CACR (i.e. some computerized tasks assumed
      not having any therapeutic effects) on the functioning of children with ADHD.
    

Intervention name(s): Computerized cognitive rehabilitation; Ritalin; Placebo CACR [PCACR]
Intervention type(s): Other; Drug; Other
Intervention description(s): - Computerized cognitive rehabilitation: 20 ninety-minute sessions of computerized cognitive rehabilitation.; -drug therapy: 2 or 3 doses of 10 mg tablets of Immediate-release Methylphenidate (Ritalin) per day for 2 months.; PCACR: 20 ninety-minute sessions of Placebo computerized cognitive training.
Other intervention name(s): Immediate release methylphenidate
Intervention MeSH terms: Methylphenidate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: ADHD
IOP Fluctuations in Patients With Primary Open-angle Glaucoma, Before and After Selective Laser Trabeculoplasty
Condition: Primary Open Angle Glaucoma; Pigmentary Glaucoma; Pseudoexfoliative Glaucoma
MeSH terms: Glaucoma; Glaucoma, Open-Angle
Study type: Interventional

Summary: 
      Selective laser trabeculoplasty (SLT) is an increasingly popular treatment modality in
      early-to-moderate glaucoma patients. SLT has been suggested to reduce IOP more consistently
      during the nocturnal period than during the diurnal period in a group of medically-treated
      patients with primary open angle glaucoma (POAG). At present, there is scarce data on SLT
      effects on the 24-hour IOP pattern in patients with glaucoma and there is no data on the
      24-hour effect of SLT in untreated glaucoma patients.

      The purpose of this study is to assess the changes of IOP over a 24-hour period in patients
      with glaucoma undergoing SLT.
    


Intervention name(s): Sensimed Triggerfish
Intervention type(s): Device
Intervention description(s): Portable investigational device using a contact lens sensor that monitors the IOP fluctuation continuously over 24-hours
Intervention model: Single Group Assignment
Masking: None (Open Label)
Keywords: Glaucoma; SLT
Bone Mineral Density in Pediatric Epilepsy
Condition: Epilepsy
MeSH terms: Epilepsy
Study type: Observational

Summary: 
      What are the effects of the currently used AEDs on bone mineralization in children and
      adolescents between the ages of 8 to 18? This is a pilot observational study using DEXA scans
      to measure bone mineral density in 100 patients The primary objective is to collect
      preliminary data on bone mineral density, body weight, dietary calcium intake, and activity
      level.
    


Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Pediatric subjects with generalized or partial seizures
The Effect of Osteopathic Manipulative Treatment on Recovery of Coronary Bypass Patients
Condition: Cardiovascular Disease
MeSH terms: Cardiovascular Diseases
Study type: Interventional

Summary: 
      The purpose of the study was to determine the effect on recovery after surgery of patients
      who received a standardized daily protocol of osteopathic manipulative treatment.Patients
      undergoing elective coronary artery bypass surgery were voluntarily enrolled in the study and
      assigned to one of three groups.One group received a standardized daily treatment protocol
      along with conventional care, another received daily similar placebo treatment with
      conventional care, and a final group received only conventional post surgical care.The
      research hypothesis was that daily treatment with osteopathic manipulative treatment would
      reduce hospital stay and hasten recovery from surgery.Persons in the treatment group had
      earlier discharge, and faster recovery of bowel function and basic mobility.
    

Detailed description: 
      Fifty-three persons were voluntarily enrolled into this randomized, double-blinded placebo
      controlled trial to examine the effects of osteopathic manipulative treatment (OMT) on the
      post operative recovery of persons undergoing elective coronary artery bypass graft (CABG)
      surgery. Participants were assigned randomly to one of three cohorts: one with only
      conventiobnal treatment, one with a daily standardized protocol of OMT and a third with a
      daily time matched placebo OMT protocol.All patients received standard state of the art care
      consistent with national standards of post CABG care. The study showed favorable trends in
      terms of hospital length of stay , return of bowel function, and mobility.
    

Intervention name(s): Osteopathic Manipulative Treatment
Intervention type(s): Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: coronary artery bypass graft; osteopathic manipulative treatment; cardiovascular disease
Magnetic Resonance Spectroscopic and Diffusion Tensor Imaging of Adolescents With Autism Spectrum Disorders
Condition: Autism Spectrum Disorders
MeSH terms: Autistic Disorder; Autism Spectrum Disorder; Child Development Disorders, Pervasive
Study type: Observational

Summary: 
      The primary objective of this study is to conduct magnetic resonance spectroscopic (MRS) and
      imaging (MRI) scans to assess the structural and neurochemical profile of the brain in 20
      children and adolescents, 6-17 years old with Autism Spectrum Disorder (ASD). For comparison,
      MRS and MRI will also be obtained from 10 healthy control subjects, matched to the 20
      subjects with ASD in age, sex, dexterity, and IQ. All eligible subjects will be administered
      a detailed assessment battery consisting of cognitive assessments (neuropsychological battery
      including subsets of the DANVA2 and the CANTAB) and measures of psychosocial functioning
      (SAICA and M-FES). The study includes 1-3 visits for the screening period at Massachusetts
      General Hospital (approximately 4 hours of assessments) and one scanning visit at McLean
      Hospital (approximately 1.5 hours).

      The investigators hypothesize that youth with ASD versus controls will exhibit increased
      glutamate concentrations, reflecting glutamatergic overactivity, and increased Cho
      concentrations, suggesting neuronal abnormality. Furthermore, the investigators hypothesize
      that compared to neurotypical controls, the structural integrity of white mater tracts will
      be disrupted in ASD.
    


Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Subjects will be recruited from current patients of The Alan and Lorraine Bressler Clinic
        for Autism Spectrum Disorders. We propose to contact by letter (via regular mail or email)
        or telephone patients who have been identified by clinicians as expressing interest in the
        study. Subjects who have participated in previous protocols in our program may also be
        eligible to participate in this study. We propose to contact by letter or telephone past
        study participants who have expressed interested in being contacted about future studies
        they may be eligible for in our office. If a potential subject's clinician ascertains that
        the patient has an interest in study participation, the clinician will only offer contact
        information for the study to the patient and/or the patient's parents. The patient and/or
        parent can then contact the study coordinator for more information on the actual study.
      
Keywords: Autism Spectrum Disorders; Pervasive Developmental Disorders; Asperger's Syndrome; Adolescents; Magnetic Resonance Spectroscopy; Diffusion Tensor Imaging
Acamprosate in the Treatment of Binge-Eating Disorder
Condition: Binge Eating Disorder
MeSH terms: Bulimia; Feeding and Eating Disorders; Binge-Eating Disorder
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      The purpose of this research study is to determine the efficacy (how well it works),
      tolerability and safety of acomprosate compared with placebo in patients with binge eating
      disorder.
    


Intervention name(s): acamprosate; placebo
Intervention type(s): Drug; Other
Intervention description(s): 999 mg/day - 2997 mg/day, oral; oral, placebo
Other intervention name(s): Campral
Intervention MeSH terms: Acamprosate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
A Pilot Study of Technetium [99Tc] Methylene Diphosphonate in the Treatment of Psoriatic Arthritis
Condition: Arthritis, Psoriatic
MeSH terms: Arthritis; Arthritis, Psoriatic
Study type: Interventional
Phase: Phase 4

Summary: 
      This study is aim to evaluate the efficacy and safety of technetium [99Tc] methylene
      diphosphonate (99Tc-MDP, trade name: Yunke) in the treatment of psoriatic arthritis.
    

Detailed description: 
      This is a single-arm, open label, 24 weeks study. Patients with psoriatic arthritis get
      99Tc-MDP 22mg (5.5mg/set, four sets) was injected intravenously once a day for 7 successive
      days, one course every 4 weeks until week 24.
    

Intervention name(s): 99Tc methylene diphosphonate
Intervention type(s): Drug
Intervention description(s): 22mg qd，Once a day for 7 consecutive days
Other intervention name(s): Yunke
Intervention MeSH terms: Diphosphonates; Methylene diphosphonate
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: 99Tc-MDP
A Study to Compare Bioavailability of Naloxone Nasal Spray, Naloxone Hydrochloride (HCl) Intravenous (IV) and Intramuscular Injection (IM) in Healthy Volunteers
Condition: Healthy Volunteer
Study type: Interventional
Phase: Phase 1

Summary: 
      The main objective of this study was to compare the bioavailability of two test formulations
      of Naloxone Nasal Spray with the reference formulations of Naloxone HCl IV and IM injection
      under fasted conditions.
    


Intervention name(s): Treatment A: Naloxone Nasal Spray; Treatment B: Naloxone Nasal Spray; Treatment C: Naloxone HCl Intravenous (IV) Injection; Treatment D: Naloxone HCl Intramuscular (IM) Injection
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Participants received naloxone nasal spray following a 10 hour fast.; Participants received naloxone nasal spray following a 10 hour fast.; Participants received naloxone HCl IV injection following a 10 hour fast.; Participants received naloxone HCl IM injection following a 10 hour fast.
Intervention MeSH terms: Naloxone
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment