The Analgesic Effect of Transversus Abdominis Plane (TAP) Block Following Radical Prostatectomy
Condition: Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      This study is conducted to evaluate different analgesic treatments effect following operation
      where the prostate gland is surgically removed.

      The different treatments the investigators wish to investigate is:

        1. Transversus Abdominis Plane (TAP) block.

           The TAP block is a rather new method, where a local anaesthetic is deposited between the
           two inner abdominal muscles. Between these muscles, the nerves that innervates the
           anterior part of the abdominal wall is situated.

        2. Wound infiltration

           In this method you deposit a local anaesthetic in the edges of the wound.

        3. Placebo

      No active local treatment is given.

      All patients who wish to participate will be allocated to one of three different treatment
      groups.

      Group 1:

      Will receive TAP block with a local anaesthetic and wound infiltration with saline.

      Group 2:

      Will receive wound infiltration with a local anaesthetic and TAP block with saline.

      Group 3:

      Will receive TAP block with saline and wound infiltration with saline.

      Beside this local treatment all patients will be given systemic Paracetamol (tablet) and
      Ibuprofen (tablet).

      In addition all patients will be given a pump containing morphine. The pump is connected to a
      button which the patient can activate when they experience pain. This enables the patient to
      control how much morphine he needs, following the operation.

      The hypothesis is that the TAP block is superior in reducing pain and thereby reducing
      morphine consumption compared to wound infiltration and placebo.
    


Intervention name(s): Naropine; Naropine; Placebo
Intervention type(s): Drug; Drug; Other
Intervention description(s): 20 mL of 0,75% Naropin is deposited on each side (40 mL in total) in the TAP.
At the same time 40 mL of saline 0,9% will be deposited subcutaneously as wound infiltration.
Both procedures is carried out at the end of the surgery while the patient is still anaesthetized and only this once.; 20 mL Saline 0,9% is deposited on each side (40 mL in total) in the TAP.
At the same time 40 mL Ropivacaine 0,75% will be deposited subcutaneously as wound infiltration.
Both procedures is carried out at the end of the surgery while the patient is still anaesthetized and only this once.; 20 mL 0,9% Saline is deposited on each side (40 mL in total) in the TAP.
At the same time 40 mL Saline 0,9% will be given as wound infiltration.
Both procedures is carried out at the end of the surgery while the patient is still anaesthetized and only this once.
Other intervention name(s): Ropivacaine; TAP block; Wound infiltration; Placebo; Ropivacaine; TAP block; Wound infiltration; Placebo; Ropivacaine; TAP block; Wound infiltration
Intervention MeSH terms: Ropivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Postoperative analgesic treatment; TAP block; Prostatectomy; Double blinded randomized clinical trial