Gut Microbiota Stunted Children NTT
Condition: Stunting
MeSH terms: Growth Disorders
Study type: Observational [Patient Registry]

Summary: 
      NTT Province is on the list of priority areas of high prevalence of stunting, Southwest
      Sumba, South Middle East, and Kupang district have a stunting prevalence of 36.2%, 34.5% and
      48.1% respectively in 2020. Therefore, it is necessary to conduct a profile study.
      microbiota, SCFA, gastrointestinal integrity, parasites, hygiene practice, and cognition in
      stunting and healthy toddlers in the province of East Nusa Tenggara,
    

Detailed description: 
      Stunting indicates a public health problem because it is associated with an increased risk of
      morbidity and mortality, decreased motor and mental function development, and reduced
      physical capacity. Stunting is a chronic nutritional deficiency condition that affects the
      growth and development, and intelligence of children. Lack of nutrients can cause intestinal
      microbiota dysbiosis where this will reduce the metabolism of short chain fatty acids (SCFA)
      which will affect the absorption of nutrients in the small intestine and cause impaired
      immunity, which in turn worsens stunting conditions. The composition of the gut microbiota is
      influenced by age, sex, geographic area and food intake. Therefore, the description of
      knowledge, attitudes and applications in society, especially mothers and child subjects, was
      also analyzed using a hygiene practice questionnaire. The aim of the study was to obtain an
      overview of the gut microbiota, gastrointestinal integrity, parasitic infections, hygiene
      practices and cognitive scores in stunting and healthy toddlers in several areas in the
      province of East Nusa Tenggara as a baseline study to be followed up by intervention study.

      The research will be conducted for 3 (three) months in 2021/2022. The subjects involved
      represented 100 stunted children and 100 healthy children aged 36-45 months from each region.
      Determination of the sample with a sampling quota. The variables studied were the nutritional
      status of under five years children, characteristics of children under five (age, gender,
      birth weight (BBL), birth length, breast feeding history, immunization history, history of
      diarrhea, history of ARI (Upper Respiratory Tract Infection)), mother and family
      characteristics (age, education). , occupation, father's occupation, total family income),
      home environment and hygiene, vaccination history, gastrointestinal microbiota status,
      gastrointestinal integrity, parasites, hygiene practices, and cognitive scores.
    

Intervention name(s): No Intervention
Intervention type(s): Other
Intervention description(s): No Intervention
Observational model: Family-Based
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        This observational study used a cross sectional design with a quantitative approach. The
        cross-sectional research design is a research conducted at one time and one time to find
        the relationship between the independent variable (risk factor) and the dependent variable
        (effect) as baseline data
      
Biospecimen description: 
      stool and blood sampling
    
Keywords: stunting; Gut microbiota; toddler; SCFA; Parasite; Hygiene Practice