PPG to Predict Ejection Fraction and Other Echographic Data in the General Population
Condition: Valvular Heart Disease; Pericardial Disease; Cardiomyopathies
MeSH terms: Heart Diseases; Cardiomyopathies; Heart Valve Diseases
Study type: Observational

Summary: 
      The investigators are aiming to investigate the association between ejection fraction (EF)
      determined by echocardiography and signals obtained from Photoplethysmography (PPG) in the
      general population. The investigators are also aiming to investigate the association between
      blood pressure and signals obtained from PPG in the general population.

      Finally, the investigators are also aiming to investigate the association between signals
      obtained from PPG in the general population to cardioechographic findings such as, valvular
      heart disease, structural heart diseases, cardiomyopathies, pericardial disease etc.
    

Detailed description: 
      The investigators are proposing a cross-sectional cohort study, where any individual, 18
      years old or older, scheduled for an echocardiography at Tulane University's outpatient
      cardiology clinic can be included. After consenting participants, information on their
      demographics, personal health habits, medications, and medical history will be collected via
      reviewing, their electronic medical health records. All participants will undergo an
      echocardiography as part of their routine medical care by their treating physician. Important
      echocardiographic findings will be noted such as, EF, valvular heart disease, pericardial
      disease, cardiomyopathies and structural heart disease. Additionally, PPG recordings will be
      collected simultaneously while performing echography using the Biostrap wristband.

      The investigators will analyze the association between each echographic imaging feature, and
      the PPG waveform obtained. PPG waveform features will be used to develop a predictive model
      capable of calculating an estimate of ventricular ejection fraction without echocardiography.
      All echocardiograms will be performed by experienced operators at Tulane Medical Center
      facilities. The study will occur at a single study site Tulane Medical Center and clinics,
      with appropriate facilities and equipment to conduct the study accurately and safely.

      An experienced echocardiogram technician or cardiology fellow will collect the PPG recordings
      using the Biostrap application. De-identified echocardiogram reports, including information
      on LVEF will be matched with the participant's pulse report.
    

Intervention name(s): Photoplethysmography
Intervention type(s): Diagnostic Test
Intervention description(s): Photoplethysmography (PPG) is a non-invasive technique that can detect volumetric changes in the peripheral blood. It only requires skin contact and relies on light absorption. PPG is a good indicator of the cardiovascular dynamics in the human body. PPG has been incorporated into various new smartphones and wearable devices such as, smartwatches and fitness wristbands making it readily available to all consumers. This sensor can record biometrics such as, heart rate, blood pressure, oxygen saturation, etc.
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        All patients undergoing an echocardiogram at Tulane Medical Center may be asked to
        participate in the study.
      
Keywords: Structural heart disease; Photoplethysmography; Ejection Fraction