Dermoscopic Findings of Small Plaque Parapsoriasis and Patch Stage Mycosis Fungoides and Histopathological Correlation
Condition: Mycosis Fungoides of Skin
MeSH terms: Mycoses; Mycosis Fungoides; Parapsoriasis
Study type: Observational [Patient Registry]

Summary: 
      Dermoscopic findings of small plaque parapsoriasis and patch stage mycosis fungoides
      (MF),histopathological correlation of the dermoscopic findings, and using these findings to
      differentiate two diseases by demonstrating the difference in diagnostic success of
      dermatologists
    

Detailed description: 
      Limited number of studies have been conducted on the dermoscopic findings of mycosis
      fungoides (MF) and small plaque parapsoriasis for the differentiation of these two diseases.
      Therefore, prospective studies involving a large number of patients and which can reach high
      magnification levels with videodermoscopy are needed to determine the criteria for
      discrimination. In our study, dermoscopic demonstration of vascularity will be achieved
      through videodermoscopy and capillaroscopy from the lesional skin, resulting in high
      magnification levels (x200).

      In terms of histopathology and dermoscopy correlation, skin punch biopsy will be taken for
      diagnostic purposes. Videodermoscopy and lesional capillaroscopy will be performed to the
      same site of the lesion where punch biopsy will be taken. As a result patients who had the
      diagnosis of mycosis fungoides or parapsoriasis will be included to our study. After
      histopathological features are evaluated by pathologists, dermoscopic correlations will be
      examined for each lesion.

      30 patients with clinical and histopathological diagnosis of mycosis fungoides, and 30
      patients with clinical and histopathological diagnosis of small plaque parapsoriasis, who
      applied to the dermatology clinic of our hospital between february 2022 and june 2022 are
      included in the study. Patients did not use systemic treatment for 4 weeks and topical
      treatments in the last 2 weeks were included to the study.

      Patient's demographical data, clinical data, videodermoscopy findings such as vascular
      structure (vascularity (shape, clustered, uniform, non-clustered) presence of scale ( diffuse
      or in patches or grooves, etc.), orange structural areas or specific clues will be evaluated.
      If vascularity is detected at x200 magnification in patients undergoing lesional
      capillaroscopy, characterization of vascularity (point, clustered, uniform, etc.) will be
      made.

      After dermoscopic criteria are determined, the individuals whose dermatology education range
      from 1 to 15 years will be randomized and divided into two groups, and the correct diagnosis
      rates will be measured, with one group only clinical and the other group clinical and
      dermoscopy images together.
    

Intervention name(s): videodermoscopy, lesional capillaroscopy
Intervention type(s): Diagnostic Test
Intervention description(s): videodermoscopy and lesional capillaroscopy will be performed under different magnification levels to the skin lesions and data will be recorded.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients who were applied to Istanbul Teaching and Research hospital dermatology clinic
        between february 2022 and june 2022 and who meet each eligibility criteria were included to
        the study.
      
Biospecimen description: 
      Skin punch biopsy samples routinely taken for diagnostic purposes and which are compatible
      with mycosis fungoides or parapsoriasis will be evaluated by the pathologists.
    
Keywords: mycosis fungoides, parapsoriasis, videodermoscopy