bioihbjkbjnl/mcl2 huggingface dataset:
Clinical Study of Umbilical Cord Mesenchymal Stem Cells Combined With Collagen Scaffold in the Treatment of Thin Endometrium
Condition: Thin Endometrium; Intrauterine Adhesion
MeSH terms: Tissue Adhesions
Study type: Interventional

Summary: 
      This is a non-blind self-control trial. We mainly compare the changes of endometrial
      thickness，changes in menstrual flow, and improvement in pregnancy before and after stem cell
      treatment in patients with thin endometrium.
    

Detailed description: 
      According to the medical history and the results of the examination, the selected cases were
      screened and the informed consent was signed. After hysteroscopy, the collagen/umbilical cord
      mesenchymal stem cell was spread on a foley catheter, and placed in the uterine cavity, and 5
      ml of saline was filled into the balloon. B-ultrasound confirmed that the stent was attached
      to the uterine wall. The balloon was removed in situ after 1 week. We mainly compare the
      endometrial thickness before and 6 months after surgery.
    

Intervention name(s): umbilical cord mesenchymal stem cells combined with collagen scaffold
Intervention type(s): Drug
Intervention description(s): 3-7 days after the end of menstruation, we underwent hysteroscopic exploration and separation if there was intrauterine adhesions. Intraoperative endometrial biopsy, recording biopsy location, endometrial specimens sent to HE examination and immunohistochemistry (vwf detection of microvessel density). The umbilical cord mesenchymal stem cell combined with collagen scaffold was spread on the balloon scaffold and placed in the uterine cavity. 5 ml of saline was filled into the balloon, and B-ultrasound confirmed that the scaffold was attached to the uterine wall. The patient was hospitalized for 2 hours and the patient's vital signs were recorded.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: thin endometrium; Intrauterine Adhesion; stem cell; Collagen scaffold
Infant Fecal Insult Study
Condition: Dermatitis
MeSH terms: Dermatitis
Study type: Interventional

Summary: 
      The rationale for the study is to better understand the dynamics of skin microflora following
      skin barrier disruption in an adult dermatitis model. The results from this study will
      provide insights in the complex interaction between skin microbiome and epidermis under
      normal and disease conditions
    


Intervention name(s): Artificial Fecal Insult; Phosphate Buffered Saline
Intervention type(s): Other; Other
Intervention description(s): protease/bile acid cocktail 200 microliters (1500 µg/ml trypsin/chymotrypsin protease mixture, 6.5 mg/ml cholic acid sodium, 6.2 mg/ml deoxycholic acid sodium, and 3.1 mg/ml chenodeoxycholic acid sodium in phosphate buffered saline; 200 microliters of phosphate buffered saline
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Randomized Controlled Trial in Liver Transplant Recipients Treated in Steroid Sparing Regimen
Condition: Chronic Hepatitis C; Organ Transplantation; Immunosuppression
MeSH terms: Hepatitis C; Hepatitis C, Chronic
Study type: Interventional
Phase: Phase 1

Summary: 
      Liver transplant subjects will be given Mycophenolate (MMF) and Tacrolimus in order to help
      prevent post-transplant rejection.
    

Detailed description: 
      Recurrent HCV in the liver allograft is becoming the leading indicator for retransplantation.
      Studies suggest that glucocorticord-based immunosuppression regimens hasten the onset and
      progression of recurrent chronic HCV liver disease. Treatment of acute allograft rejection
      with steroid boluses is also associated with rapid HCV recurrence. The relative contribution
      of various calcineurin inhibitors to recurrent HCV liver disease has not been established.
      Previous retrospective studies, as well as prospective studies have not demonstrated a
      difference in recurrent HCV liver disease rates between patients receiving CsA or tacrolimus
      immunosuppression regimens respectively.
    

Intervention name(s): Neoral; Tacrolimus
Intervention type(s): Drug; Drug
Intervention MeSH terms: Tacrolimus
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Feasibility of Superior Rectal Artery Embolization for the Treatment of Hemorrhoidal Disease
Condition: Hemorrhoidal Disease
Study type: Interventional

Summary: 
      With an estimated prevalence between 4 and 35%, the hemorrhoidal disease is the most frequent
      proctologic disease. Its symptoms are mainly rectorrhagia, externalization of the
      hemorrhoidal cushions (muco-hemorrhoidal prolapse), and/or pain and pruritus. Its acute
      complications (external and/or internal thromboses) are unpredictable.

      Surgical treatment concerns approximately 10% of patients with diagnosed hemorrhoidal
      pathologies. The elective ligature of the arteria haemorrhoidalis under trans-anal Doppler
      scanning was developed in order to reduce the postoperative morbidity of hemorrhoidal
      surgery. This technique consists in a ligation of the superior rectal artery under Doppler
      control in order to decrease the blood flow within the hemorrhoids and therefore to reduce
      them. It is effective in the treatment of internal hemorrhoidal pathology without prolapse
      (grade II). The complications rate is low and estimated between 2 and 12% : rectorrhagia
      (4.3%), thrombosed hemorrhoids (1,8%), fissure (0,8%), acute urine retention (0,7%).

      With the major advances in interventional radiology such ligation could be performed by an
      endovascular coil embolization. Until now no direct study exists on the subject but several
      case reports show the feasibility of an embolization of the superior rectal arteries for
      rectorrhagia of various etiologies such as the hemorrhoidal disease.

      Endovascular access should increase the selectivity of the embolization compared to the
      Doppler scanning technique. Indeed the arteriography makes it possible to scan all branches
      of the superior rectal artery and therefore to occlude permanently the branches that feed the
      hemorrhoidal plexuses. Moreover the endovascular embolization technique should avoid the main
      complications of the trans-anal access technique.

      The primary objective of this study is : the assessment of the efficacy of endovascular coil
      embolization of the superior rectal arteries in the management of the symptoms of the
      hemorrhoidal disease grade II and III. The secondary objective is : the assessment of
      postoperative complications.
    


Intervention name(s): NESTER COILS
Intervention type(s): Device
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of F2695 on Functional Recovery After Ischemic Stroke
Condition: Ischemic Stroke
MeSH terms: Stroke; Ischemic Stroke; Cerebral Infarction; Ischemia
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of the study is to assess the efficacy of a new serotonin-norepinephrine reuptake
      inhibitor (SNRI) nin functional recovery after ischemic stroke.
    


Intervention name(s): F2695; placebo
Intervention type(s): Drug; Drug
Intervention description(s): 75 mg OD in 2 capsules; 2 capsules
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Intuitive Eating for Disordered Eating
Condition: Eating Disorder Symptom; Eating Behavior; Body Image; Psychological Distress
MeSH terms: Feeding and Eating Disorders
Study type: Interventional

Summary: 
      Purpose: Research on intuitive eating is growing, but there are few interventions
      demonstrating the effect of learning to eat intuitively for people with disordered eating.
      Young women in particular are at high-risk for developing disordered eating. This study aimed
      to test the outcomes of a novel intuitive eating intervention for young women with disordered
      eating.

      Methods: This study is the first randomized controlled trial introducing intuitive eating to
      a sample of participants with disordered eating. Participants with current eating disorders
      were excluded from this study. Women (n=123) ages 18-30 with high levels of disordered eating
      participated in this study and were randomized to either a treatment (10-week web-based
      intervention) or control group (10-week waitlist).
    


Intervention name(s): Intuitive Eating Treatment
Intervention type(s): Behavioral
Intervention description(s): Participants received a brief web-based intervention for disordered eating which focused on a style of eating behavior called "intuitive eating". Please see arm description for more details.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Usefulness of Antibiotics in Smokers Receiving Dental Implants
Condition: Dental Implant Therapy
Study type: Interventional

Summary: 
      Objectives: This randomized clinical trial will compare the usefulness of pre- and
      postoperative antibiotics while strict asepsis will be followed during periodontal surgery in
      smokers diagnosed with Stage III Grade C Generalized Periodontitis.

      Material and Methods: Two groups of 40 consecutive patients each with fully or partially
      edentulous jaws will be enrolled. Antibiotics group (GrAB+): will receive oral doxycycline
      200 mg, 1 h pre-operatively and 100 mg g for 9 days post-operatively. Non-antibiotics group
      (GrAB- ): will receive a placebo (no antibiotics). Bacterial samples will be taken from the
      peri-oral skin before and at the end of the surgery. In 12 patients in each group, samples
      will also be taken from the nares. A visual analogue scale will evaluate symptoms of
      infection/ inflammation by both the patient and the periodontist at suture removal.
    


Intervention name(s): Antibiotic group; Non-Antibiotic group
Intervention type(s): Procedure; Procedure
Intervention description(s): Partially or fully edentulous smoker patients will be treated by dental implants and will receive systemic antibiotics; Partially or fully edentulous smoker patients will be treated by dental implants and will receive placebo
Other intervention name(s): Dental implant insertion + Antibiotics; Dental implant insertion + Placebo
Intervention MeSH terms: Anti-Bacterial Agents; Antibiotics, Antitubercular
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Electrophysiological Study of Spatiotemporal Gait Parameters in Patients in Early Stage of Multiple Sclerosis
Condition: Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Sclerosis
Study type: Observational

Summary: 
      35 patients with multiple sclerosis have been enrolled in a previous study to record and
      analyze gait parameters.

      This study aims to enroll gender and and matched healthy subjects for a control group, to
      compare patients' gait parameters with healthy subjects'.
    


Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        35 patients with multiple sclerosis progressing for less than 5 years, age 18 to 54 years
        old, and handicap score (EDSS) < 2 in all the subscores concerning gait, have been enrolled
        in a previous observational study recording and analyzing gait parameters.

        This study aims to enroll gender and aed matched healthy subjects for a control group, to
        compare patients' gait parameters with healthy subjects'.

        The 35 patients have given their consent for this new data analysis.
To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock
Condition: Cirrhosis With Septic Shock
MeSH terms: Shock, Septic; Liver Cirrhosis; Shock; Fibrosis
Study type: Interventional

Summary: 
      The consecutive patients admitted to Intensive care unit of Hepatology department of ILBS and
      full filling all the eligibility criteria will be enrolled in 1:1 ration by the process of
      randomization.- The study is an open level study. The investigators will strictly follow the
      randomization table to give therapy as per the intervention arm.

        -  Intervention:-the therapeutic intervention is vasopressor i.e. noradrenaline alone and
           terlipressin along with noradrenaline to maintain the MAP >65mm Hg.

        -  Intervention arm

             -  Arm (A) - Noradrenaline

             -  Arm (B) - Noradrenaline + low dose terlipressin
    


Intervention name(s): Low dose terlipressin; Noradrenaline; Noradrenaline
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Terlipressin-2mg (low dose ); Noradrenaline at 7.5 mcg/min, maximum of 60mcg/min. stepped up every 15 min; Noradrenaline- 3.75 mcg/min to 30 mcg/min. stepped up every 15 min
Intervention MeSH terms: Terlipressin; Norepinephrine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Probiotic Lozenge Reduce Streptococcus Mutans in Plaque in Orthodontic Bracket Patients
Condition: Malocclusion
MeSH terms: Malocclusion
Study type: Interventional
Phase: Phase 3

Summary: 
      Advances in orthodontics have improved the quality of appliances and treatment protocols,
      raising the standard of patient care. However, enamel demineralization is still a problem
      associated with orthodontic treatment, leading to the formation of white spot lesions; this
      is a grave concern to orthodontists and patients.

      The overall prevalence of white spot lesions among orthodontic patients has been reported to
      be between 4.9% and 84%.1 When basic oral hygiene is poor, orthodontic appliances create
      areas of plaque stagnation, especially around brackets, bands, wires, and other attachments.
      Levels of acidogenic bacteria, present in the plaque, notably Streptococcus mutans (S
      mutans), are higher in orthodontic patients than in non-orthodontic patients.

      This causes demineralization around the brackets and leads to white spot lesions. They are
      most prevalent around the cervical region of bands in the posterior region, whereas in the
      anterior region, the lateral incisors in both arches, followed by the canines, are most
      commonly affected.
    


Intervention name(s): Probiotic (L. brevis CD2 lozenges); Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Each Lactobacillus brevis CD2 lozenge contains not less than 1 billion Colony Forming Unit of L. brevis CD2; Each placebo lozenge contains all excipients except the active constituent (Lactobacillus brevis CD2)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: misalignment of the two dental arches; mal-align teeth
A Study to Assess the Effect of a Single Dose of ASP8062 on the Multiple Dose Safety, Tolerability and Pharmacokinetics of Buprenorphine/Naloxone in Participants With Opioid Use Disorder
Condition: Opioid Use Disorder
MeSH terms: Opioid-Related Disorders; Substance-Related Disorders
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary purpose of this study was to assess the safety and tolerability of multiple doses
      of buprenorphine/naloxone alone and buprenorphine/naloxone in combination with a single dose
      of ASP8062.

      This study also assessed the potential for pharmacokinetic interaction between ASP8062 and
      buprenorphine/naloxone.
    

Detailed description: 
      Participants were screened for up to 28 days prior to first investigational product (IP)
      administration. Eligible participants were admitted to the clinical unit on day -1 and were
      residential for a single period of 27 days/26 nights.

      Participants were discharged from the clinical unit after completion of down-titration on the
      condition that all required assessments were performed and that there were no medical reasons
      for a longer stay in the clinical unit; which was the end-of-study visit (ESV). Prior to
      discharge, participants were provided with local buprenorphine and methadone providers for
      their reference.
    

Intervention name(s): ASP8062; Placebo ASP8062; buprenorphine/naloxone
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Oral; Oral; Sublingual
Other intervention name(s): Suboxone®
Intervention MeSH terms: Buprenorphine; Buprenorphine, Naloxone Drug Combination; ASP8062; Naloxone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Suboxone®; Opioid Use Disorder; buprenorphine/naloxone; ASP8062; pharmacokinetic
Characteristics and the Future of the City Chilblains
Condition: Chilblains
MeSH terms: Chilblains
Study type: Observational

Summary: 
      Chilblains are cutaneous lesions affecting extremities (foot and fingers) with erythemic
      papules, evolving by painful relapse due to cold and sudden reheating.

      This pathology is currently poorly understood while it's frequent.

      The aim of the study is to evaluate all the characteristics of this pathology by reporting
      clinical and biological data of patient consulting for chilblains; and the other point is to
      assess the evolution of these patients.
    

Detailed description: 
      Investigators are going to collect data on patient medical report to fill up a case report
      form. And in a second time they call patient by phone to ask him/her about the evolution of
      their pathology.
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        every patient consulting for chilblains between 2012 and 2014
Pilates to Treat Neck Pain
Condition: Mechanical Neck Pain
MeSH terms: Neck Pain
Study type: Interventional
Phase: Phase 3

Summary: 
      The neck pain comes from disturbances related to the cervical spine, of multifactorial origin
      and is considered a frequent problem of disability.

      Pilates is a physical conditioning method that has been widely used to improve posture and
      develop body awareness.

      The aim of this study is to assess the impact of the Pilates method in the control of pain,
      function and quality of life in patients with chronic mechanical neck pain.

      Methods: 64 patients with chronic mechanical neck pain will be selected and randomized into
      two groups: intervention and control. Both groups will be assessed for pain, function,
      quality of life and medication intake.

      The intervention group will hold Pilates sessions for three months, with two sessions per
      week. The control group will continue with the usual drug treatment. Both groups will be
      instructed to use 750mg acetaminophen every 6 hours if there is pain, but consumption of the
      drug will be controlled.

      Although the symptoms of neck pain are common in the population, no study has investigated
      the effects of the Pilates method as a possible treatment for neck pain. The hypothesis is
      that the Pilates method can offer benefits to these patients.
    


Intervention name(s): Pilates
Intervention type(s): Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Mechanical Neck Pain; Pain; Function; Quality of life; Pilates
Bioequivalence Study of Citalopram Hydrobromide Tablets 40 mg of Dr.Reddy's Laboratories Limited Under Fasting Conditions
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a bioequivalence study of Citalopram Hydrobromide Tablets 40 mg of Dr.Reddy's
      Laboratories Limited under fasting conditions.
    

Detailed description: 
      randomized, 2-way crossover; bioequivalence study of citalopram hydrobromide 40mg tablets and
      celexa 40 mg tablets administered as

      1 x 40 mg tablet in healthy subjects under fasting conditions
    

Intervention name(s): Citalopram Hydrobromide
Intervention type(s): Drug
Intervention description(s): Citalopram Hydrobromide Tablets 40 mg of Dr.Reddy's Laboratories Limited
Other intervention name(s): Celexa Tablets 40 mg
Intervention MeSH terms: Dexetimide; Citalopram; Escitalopram
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Bioequivalence; Citalopram; Crossover
The Neural Representation of Self in Depression Patients
Condition: Depression Disorder; Healthy
MeSH terms: Depression; Depressive Disorder
Study type: Observational [Patient Registry]

Summary: 
      To be aware of oneself as a unique entity in the world occurs early in human development and
      is the prerequisite of normal social functioning. The disturbance of self representation
      characterizes a variety of mental disorders such as autism and schizophrenia. Negative
      self-bias was found to serve as the core cognitive mechanism of depression disorder. However,
      there was no evidence to show the reason lead to negative bias. In the current study,
      investigators hypothesized that the blurring self representation was the neural correlates in
      depression disorder.
    

Detailed description: 
      To test investigators' hypothesis, investigators adopted the self-referential task and fMRI
      to investigate the neural representation of self in depression patients, and compared with
      healthy control.
    

Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Individuals diagnosed with depression and healthy control
      
Keywords: depression, self-referential, neural representation