bioihbjkbjnl/mcl2 huggingface dataset:
Bone Loss in Posterior Mandible Postextraction Sockets
Condition: Guided Bone
Study type: Observational

Summary: 
      The aim of this study is to evaluate the bone loss after extraction. The surgery protocol is
      flapless, and the teeth are mandibular premolars or molars leaving sockets with 4 walls
      intact or at least 3 walls intact and the buccal wall at 80% . This study will include 40
      patients
    

Detailed description: 
      Primary objective :

      Estimate the percentage of bone volume loss o and the percentage thickness loss of the buccal
      and palatal cortical for patients who underwent natural healing in the mandibular molar and
      premolar areas.

      Methods :

      Before tooth extraction of a premolar or molar in mandibular area by flapless technique, a
      CBCT preoperative is performed to verify the integrity of cortical and measure the height and
      width of the residual cavity. Caliper measurements will also be performed during surgery in
      order to integrate also the thickness of the bone tables and gingival thickness.

      After natural healing , the pre-implant scan performed at six months postoperatively will
      measure the height and width of the grafted cell, to compare measurements and evaluate the
      dynamics of alveolar resorption.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Population of patients aged between 18 and 80 years with one to two posterior mandibular
        teeth to extract in absence of bone graft and able to benefit from a flapless technique.
      
Keywords: Regeneration
VEGF Trap in Treating Patients With Solid Tumors or Non-Hodgkin's Lymphoma
Condition: Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific
MeSH terms: Lymphoma
Study type: Interventional
Phase: Phase 1

Summary: 
      RATIONALE: VEGF Trap may stop the growth of solid tumors or non-Hodgkin's lymphoma by
      stopping blood flow to the cancer.

      PURPOSE: Phase I trial to study the effectiveness of VEGF Trap in treating patients who have
      relapsed or refractory solid tumors or non-Hodgkin's lymphoma.
    

Detailed description: 
      OBJECTIVES:

        -  Determine the long-term safety and tolerability of VEGF Trap in patients with incurable
           relapsed or refractory solid tumors or non-Hodgkin's lymphoma with stable or responding
           disease after receiving treatment on protocol MSKCC-01131.

        -  Determine the biological effect of this therapy on suppressing tumor growth or
           progression in these patients.

        -  Determine the steady state concentration of VEGF Trap over time in these patients.

        -  Determine whether patients develop antibodies to this therapy during extended exposure.

      OUTLINE: This is an extension study for patients who showed evidence of stable disease or
      complete or partial remission after completing treatment on protocol MSKCC-01131.

      Patients continue to receive VEGF Trap subcutaneously once weekly for up to an additional 6
      months in the absence of unacceptable toxicity. Patients receive treatment at the same dose
      level as on protocol MSKCC-01131.

      Patients are followed at approximately 30 days.

      PROJECTED ACCRUAL: A maximum of 30 patients will be accrued for this study.
    

Intervention name(s): ziv-aflibercept
Intervention type(s): Biological
Intervention MeSH terms: Aflibercept
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: recurrent adult diffuse large cell lymphoma; recurrent adult diffuse mixed cell lymphoma; recurrent adult diffuse small cleaved cell lymphoma; recurrent adult Burkitt lymphoma; recurrent adult immunoblastic large cell lymphoma; recurrent adult lymphoblastic lymphoma; recurrent grade 1 follicular lymphoma; recurrent grade 2 follicular lymphoma; recurrent grade 3 follicular lymphoma; recurrent mantle cell lymphoma; stage IV adult diffuse large cell lymphoma; stage IV adult diffuse mixed cell lymphoma; stage IV adult diffuse small cleaved cell lymphoma; stage IV adult Burkitt lymphoma; stage IV adult immunoblastic large cell lymphoma; stage IV adult lymphoblastic lymphoma; stage IV grade 1 follicular lymphoma; stage IV grade 2 follicular lymphoma; stage IV grade 3 follicular lymphoma; stage IV mantle cell lymphoma; unspecified adult solid tumor, protocol specific; recurrent marginal zone lymphoma; recurrent small lymphocytic lymphoma; stage IV small lymphocytic lymphoma; stage IV marginal zone lymphoma; extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue; nodal marginal zone B-cell lymphoma; splenic marginal zone lymphoma
Safety Dermatological Evaluation: Acceptability With Gynecological Follow up - Dermacyd Tina Gel Sweet Flower
Condition: Hygiene
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to demonstrate the safety of the gynecological formulation in
      normal and usual usage condition of Dermacyd Tina Gel Sweet Flower.
    


Intervention name(s): Lactic acid (Dermacid)
Intervention type(s): Drug
Intervention description(s): Liquid soup to be applied in the external genital area, in a small quantity, with abundantly rinse after use, during 21 days.
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Bronchial Inflammation in Patients With Bronchiolithis Obliterans
Condition: Bronchiolitis Obliterans
MeSH terms: Bronchiolitis; Bronchiolitis Obliterans; Bronchiolitis Obliterans Syndrome; Inflammation
Study type: Observational

Summary: 
      The investigators plan to study the variability of lung function parameters and bronchial
      inflammatory markers in 20 patients with bronchiolitis obliterans at the age of 6 to 25 years
      compared with an age- and sex-matched control group. The investigators will perform a
      pulmonary function test (body plethysmography with TLCO), and measure the fraction of exhaled
      nitric oxide (eNO). Further a blood sample is drawn to determine the systemic inflammation.
      Finally induced sputum is collected and a cell count is performed, and cells and supernatants
      are analyzed for inflammatory markers. This investigation will be repeated after 4-6 weeks.
      The aim of this study is to define baseline values and the variability of possible outcome
      parameters for future interventional studies.
    

Detailed description: 
      The purpose of this study is to characterize the variability of lung function values and
      bronchial inflammation of 20 Patients with Bronchiolitis obliterans aged between 6 up to 25
      years. The patients' data will be compared with the results of a reference group with similar
      age conditions to determine possible outcome-parameters for following interventional studies.

      The sputum samples will be processed and quantitatively analyzed to get a profile of the
      cytological composition.

      (Sputum and serum samples are analyzed by quantitative real-time polymerase chain reaction
      (PCR) (qRT-PCR) and by cytometric bead assay (CBA).)

      Methods and Work Programme:

      This study consists of two study visits (V1 and V2)

      V1:

        -  Measurement of nitric oxide in expired air (eNO)

        -  Lung function testing with spirometry and body plethysmography

        -  Bronchodilation

        -  Lung function testing with spirometry and body plethysmography

        -  Blood test: blood count, CRP, RAST, serum inflammatory mediators, (genetic markers of
           the non-specific pulmonary defense system)

        -  Induced sputum for inflammatory mediators and microbiological investigations

      V2:

        -  Measurement of nitric oxide in expired air (eNO)

        -  Lung function testing with spirometry and body plethysmography

        -  Bronchodilation

        -  Lung function testing with spirometry and body plethysmography

        -  Induced sputum for inflammatory mediators and microbiological investigations
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients suffering from Bronchiolitis obliterans and controls
      
Biospecimen description: 
      blood, sputum cells, sputum supernatans
    
Keywords: bronchial inflammation; Bronchiolitis obliterans; Sputum; Blood; Inflammation; adaptive immune system; innate immune system
Effects of a Task Oriented Intervention With Two Goal-setting Approaches
Condition: Movement Disorder; Learning Disability; Autism Spectrum Disorder; Children
MeSH terms: Movement Disorders; Learning Disabilities; Autism Spectrum Disorder
Study type: Interventional

Summary: 
      A randomized trial investigating if effects of a goal-directed task oriented intervention is
      influenced by who takes the decision and establishes the goal (the child or the parent) and
      whether establishing a goal per se influence performance and goal-achievement. The main
      hypothesis are that children's participation in the goal-setting process would positively
      influence goal achievement, children's self-identified goals would be achievable and that
      both groups would achieve goals that were the target of a goal-directed intervention.
    


Intervention name(s): child-goal; parent-goal
Intervention type(s): Behavioral; Behavioral
Intervention description(s): The 8-week goal-directed intervention include completing a daily home program and a weekly follow-up session with the child's occupational therapist.
The parents are responsible for the day to day practice and are encouraged to let the children practice daily in their natural environment.
The home-programs focus on enhancing the agreed upon goal specific task performance. They include structured practice of tasks and adaptations and modifications of the environment and the tasks.
The weekly sessions with the occupational therapist are meant to sustain motivation, follow-up on progress, adjust the home program for the coming week and support parents in how to carry out the daily interventions.; The 8-week goal-directed intervention include completing a daily home program and a weekly follow-up session with the child's occupational therapist.
The parents are responsible for the day to day practice and are encouraged to let the children practice daily in their natural environment.
The home-programs focus on enhancing the agreed upon goal specific task performance. They include structured practice of tasks and adaptations and modifications of the environment and the tasks. .
The weekly sessions with the occupational therapist are meant to sustain motivation, follow-up on progress, adjust the home program for the coming week and support parents in how to carry out the daily interventions.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Clinical Study of AK101 in Subjects With Moderate to Severe Plaque Psoriasis
Condition: Plaque Psoriasis
MeSH terms: Psoriasis
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a multiple-center, randomized, double-blind, placebo-controlled Phase IIb study to
      evaluate the efficacy and safety of AK101, an anti-IL-12/23 p40 antibody, when administered
      subcutaneously, in subjects with moderate-to-severe plaque psoriasis. The study will consist
      of 3 periods: up to 4 weeks screening, 12 weeks double-blinded treatment and long-term
      follow-up period(up to 52 weeks).
    


Intervention name(s): AK101; Placebo
Intervention type(s): Biological; Biological
Intervention description(s): an anti-IL-12/23p40 monoclonal antibody; matching placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: IL12/23
Anemia in Orthopedic Surgery - Determination of Hb
Condition: Anemia
MeSH terms: Anemia
Study type: Observational [Patient Registry]

Summary: 
      Anemia prevalence in orthopedic surgery is up to 30 %. Identifying those patients prior to
      surgery and treating them would be ideal. Different ways of determining hemoglobin Levels are
      available. In this study classical laboratory determination, determination with HemoCue® and
      Rad-67™ will be performed to compare precision of those three methods as well as their
      correlation.
    


Intervention name(s): Hemocue and Rad-67 measurement
Intervention type(s): Device
Intervention description(s): Measurement of the hemoglobin level
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        All patients scheduled for elective orthopedic surgery.
      
Keywords: preoperative; orthopedic surgery
Epidural Steroid Injection Versus Epidural Steroid Injection and Manual Physical Therapy and Exercise in the Management of Lumbar Spinal Stenosis
Condition: Lumbar Spinal Stenosis
MeSH terms: Spinal Stenosis; Constriction, Pathologic
Study type: Interventional

Summary: 
      Lumbar spinal stenosis (LSS) is a prevalent and disabling condition in the rapidly growing
      aging population. People with LSS often have a substantial physical and psychosocial burden
      as well as significant healthcare costs affecting both the individual and society. It has
      been reported that patients with LSS over the age of 65 are more likely to undergo spinal
      surgery than any other condition with an estimated total annual inpatient expense of one
      billion. Individuals undergoing surgical treatment for LSS tend to be older, therefore
      operative morbidity and mortality are a particular concern. Functional benefit derived from
      conservative treatment may increase the health and quality of life for individuals suffering
      from LSS and avoid or delay the need for surgery in some subjects. As the population
      continues to age, identifying effective non-surgical treatment options for older patients
      with LSS is an important research priority. Ultimately, the information gained from this
      study will help fill a significant void in medical literature regarding non-surgical options
      for this patient population.
    


Intervention name(s): Epidural steroid injection plus physical therapy; Epidural steroid injection
Intervention type(s): Other; Other
Intervention description(s): Patients in the ESI+PT Group will be treated additionally with a physical therapy program emphasizing lumbar flexion exercises, aerobic and strength/ conditioning exercises, and manual physical therapy as well as receiving up to 3 epidural steroid injection(s) and educational support using The Back Book.; Patients in the ESI Group will be treated with up to 3 epidural steroid injections, educational support, and general care by the treating physician.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Satiation Study With Children Attending a Tertiary Feeding Clinic
Condition: Undernutrition; Underweight
MeSH terms: Malnutrition; Thinness
Study type: Interventional

Summary: 
      This is a pilot study of children attending the Glasgow feeding clinic (GFC) which looks
      after children with severe feeding problems who commonly have low appetite and extreme
      thinness. The investigators want to find out if thin children respond to food in the same
      way, using an established method to assess energy compensation.
    

Detailed description: 
      Thinness occurs as a result of undereating, but it is not always clear why an individual
      child has not eaten enough, or how to get them to eat more. There is a need to understand the
      child characteristics that predispose to undereating and the how these operate, in order to
      design more effective treatment and prevention programmes. The Glasgow feeding clinic (GFC)
      looks after a range of children with severe feeding problems who commonly have low appetite
      and extreme thinness.

      A Ghanaian student will come to Glasgow, funded by the Glasgow University /Scottish funding
      council Global Challenges Research fund, to learn these techniques to use in future PhD
      research. The student will conduct a pilot study of children attending the GFC. The student
      will invite 40 families to complete our standardised online questionnaire (ICFET) about their
      child's eating behaviour and collate existing growth measurements as well as their feeding
      history.

      A standardised energy compensation study will then be undertaken in 20 of the thinnest
      children. At two visits at least a week apart, the children will be given one of two similar
      tasting drinks in random order, one with very few calories and another with extra, without
      them knowing which is which. After 30 minutes they will eat as much as they want of a
      standardized lunch. All foods and drinks offered will be weighed before and after, to
      calculate the amount of energy eaten in total after the low energy drink, compared to the
      high energy drink.
    

Intervention name(s): High Energy preload; Low energy preload; Test meal
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Tests the extent to which participants reduce their intake at a meal following ingestion of a high energy preload drink; Tests the amount participants eat at a meal following ingestion of a low energy preload drink; Test meal to follow low or high energy preload
Other intervention name(s): Satiation study; Satiation study
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: cross-over energy compensation study, participants acting as their own controls
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
LCPUFA Supplementation: A Multi-Modality Imaging Study
Condition: Child Development
Study type: Observational

Summary: 
      The purpose of this study is to take images of the brain in order to see if long-chain
      polyunsaturated fatty acid (LCPUFA) exposure during infancy influences brain structure and
      function in middle childhood.
    

Detailed description: 
      LCPUFAs are essential fatty acids that are found in all cells of the body, particularly in
      the brain, retina and other nervous tissue. LCPUFAs are found naturally in seeds, nuts, fish
      and human breast milk. The body can also make LCPUFAs from shorter-chain fatty acid
      precursors.

      The researchers in the study have previously found that LCPUFA supplementation during infancy
      has a beneficial effect on vision and development in the early years of life. However,
      researchers feel there is a growing need to better understand if there are structural and/or
      functional changes in the brain that explain these benefits. It is also important to
      understand if changes in development are still present later in childhood.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Subjects who were originally enrolled as infants will be invited to participate in the
        longitudinal follow up study.
      
Biospecimen description: 
      cheek swab
    
Keywords: LCPUFA supplementation; Brain Imaging; MRI; MEG
Effect of the Addition of Dexmedetomidine to Bupivacaine During Supraclavicular Brachial Plexus Blockade
Condition: Sequelae of Fracture of Forearm and Upper Arm
Study type: Interventional
Phase: Phase 4

Summary: 
      the aim of this study was effect of the addition of dexmedetomidine to bupivacaine during
      supraclavicular brachial plexus blockade for forearm surgery, by low doses bupivacaine
      providing prolonged analgesia after surgery.
    

Detailed description: 
      Anaesthesia for surgeries to the upper extremity commonly is provided using brachial plexus
      anaesthesia.Various local anaesthetic mixtures can be used to prolong local anaesthesia
      duration and epinephrine , opioids and dexmedetomidine are frequently used for this purpose.
      this study was conducted to compare the effects of adding dexmedetomidine to local
      anaesthetics in the supraclavicular brachial plexus block by using nerve stimulators and
      ultrasonography guided. dexmedetomidine has also been found the prolong the duration of
      bupivacaine infraclavicular brachial plexus block.
    

Intervention name(s): dexmedetomidine; bupivacaine
Intervention type(s): Drug; Drug
Intervention description(s): 1 ml 100 mcg dexmedetomidine+ 15 ml 0.25 % bupivacaine are applied around brachial plexus; 30 ml 0.25 % bupivacaine is applied around brachial plexus
Other intervention name(s): precedex; marcaine
Intervention MeSH terms: Dexmedetomidine; Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Supraclavicular block
Chlorhexidine Disk for Prevention of Exit-site Infection in Peritoneal Dialysis Patients
Condition: Peritoneal Dialysis Catheter Exit Site Infection
MeSH terms: Infections; Communicable Diseases
Study type: Interventional

Summary: 
      The purpose of the study is to evaluate the efficacy and safety of chlorhexidine-impregnated
      disk in preventing catheter exit-site infection in peritoneal dialysis patients
    

Detailed description: 
      The primary aim of the study is to examine the exit-site infection rate in patients using
      chlorhexidine-impregnated dressing.

      The participant will be followed up at 2, 6, 12, 24, 36 and 52 weeks of study and during each
      visit the catheter exit-site will be examined by one of the investigators for any sign of
      infection or allergic reaction, and questionnaires about satisfaction with use of study
      material (biopatch) will be asked by a study team member at the 12 week visit of the study.
      Each participant will be followed up for one year.
    

Intervention name(s): Chlorhexidine-impregnated disk
Intervention type(s): Device
Intervention description(s): The chlorhexidine-impregnated sponge, named biopatch, is a protective disk (2.5 cm x 0.7 cm), which is hydrophilic polyurethane absorptive foam with chlorhexidine gluconate, in average of 86.8mg per disk
Other intervention name(s): biopatch disk
Intervention MeSH terms: Chlorhexidine
Intervention model: Single Group Assignment
Intervention model description: Prospective cohort study
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: peritoneal dialysis; chlorhexidine; exit site infection; tunnel tract infection