bioihbjkbjnl/mcl2 huggingface dataset:
Treatment for Nicotine Addiction in Women
Condition: Nicotine Dependence
MeSH terms: Tobacco Use Disorder
Study type: Interventional

Summary: 
      The purpose of this study is to use a medication tolcapone and or placebo to test if the
      symptoms of nicotine withdrawal lessens , and or changes in smoking urges, and mental
      reasoning in female smokers over a 72 hour period.
    

Detailed description: 
      The proposed trail will be use a double-blind, placebo-controlled design to conduct the first
      randomized controlled trial of the COMT inhibitor, tolcapone, in nicotine dependent women.
      This study will determine if tolcapone is superior to placebo by attenuation the severity of
      nicotine withdrawal and smoking urges during short-term abstinence. Withdrawal severity will
      be assessed by a self-report scale and cognitive assessment, including a sustained-attention
      task. Smoking urges will be assessed by a self-report scale.
    

Intervention name(s): Tolcapone; Sugar Pill
Intervention type(s): Drug; Drug
Intervention description(s): Tolcapone will be compared to sugar pill; The sugar pill (placebo) will be compared to tolcapone
Other intervention name(s): Tasmar; Placebo
Intervention MeSH terms: Tolcapone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Comparison of the Effect of MCFA and LCFA on Postprandial Appetite and Lipemia
Condition: Lipemia
MeSH terms: Hyperlipidemias
Study type: Interventional

Summary: 
      The main objective is to investigate if foods high in coconut oil (MCFA) or palm oil (LCFA)
      have different impacts on postprandial blood lipid levels and appetite via a visual analog
      scale (VAS).
    

Detailed description: 
      Postprandial lipemia has been recognized as a cardiovascular disease risk factor. The rate of
      postprandial triglyceride production and clearance in the blood, as well as the appetite, are
      influenced by the quality of the food consumed, such as the length of saturated fatty acids.
      The study will include 24 healthy adults ranging in age from 18 to 40 years old, of both
      sexes and it will be conducted at the University of Jordan. The study will involve two
      experimental test days, each separated by at least a week of washout interval, and each test
      day will last for 6 hours. All subjects will be randomly assigned to one of the experimental
      meals using computer-generated tables. Blood serum samples (2 mL) will be taken after an
      overnight fast and 2, 4, and 6 hours after eating the meals, and blood lipid profiles [total
      cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein
      cholesterol (HDL-C), and triglyceride (TG)] will be examined in a private lab. After that,
      participants will be allowed an ad libitum intake of standard meals. Each meal will be
      weighed before and after it is consumed, with the amount of food ingested being calculated.
    

Intervention name(s): Coconut oil; Palm oil
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Coconut oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits.; Palm oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: randomized crossover single-blinded intervention study
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Postprandial lipemia
Prone or Supine Extubation in Lomber Spinal Surgery
Condition: Lumbar Spinal Stenosis
MeSH terms: Spinal Stenosis
Study type: Observational

Summary: 
      The aim of this study was to investigate the emergence quality of patients extubated on prone
      or supine position after lumbar spinal surgery.

      60 patients with ASA I-II who underwent lumbar spinal surgery between 18-65 years of age were
      included in the study. Patients with difficult intubation, BMI> 35kg / m2, asthma and
      reactive airway problems, cardiovascular disease and obstructive sleep apnea will not be
      included in the study. Initial data will be recorded after standard monitorization. Induction
      is made by 2 mg / kg propofol, 1 mg / kg fentanyl and 0.5 mg / kg rocuronium will be added
      for muscle relaxation. Patients with adequate muscle relaxation will be intubated with
      appropriate endotracheal tube and mechanical ventilation will be initiated. Patients who are
      then given prone positions on the operating table will be supported with side gels. The head
      will be placed in the face gel in a neutral position. For intraoperative analgesia,
      remifentanil infusion at 0.2mcg / kg / min will be applied.

      After laminectomy is completed and control of bleeding, 1 mg / kg Tramalol and 2 mg / kg
      Metaclopromide will be applied to all patients. At the end of the skin stitching, the
      inhalation agent will be closed and the fresh gas will be turned 6 lt 100% O2. Patients who
      want to be extubated in the prone position are left in this position while the other patients
      will be placed on the stretcher in a supine position for a short time. Patients will be
      decurarized be neostigmin with atropine. Extubation will be performed in both positions when
      spontanous ventilation begins at a tidal volume of 6ml / kg and a frequency of 12-20 / min.
      All the measures will be taken to ensure airway safety while the patient is extubated pron.
      The stretcher will be brought to the side of the operating table, investigator will be ready
      for reintubation and all the necessary persons will be with the patient. Aspiration frequency
      will be recorded for each patient. During recovery after extubation, the severity of cough
      will be evaluated as mild (only once), less (more than one but not continuous) and severe
      (continuously for 5 seconds). Aldrate scores of patient will be recorded and first 9-10 time
      is estimated from extubation time. Vomiting, nausea, respiratory insufficiency, inability to
      control the airway and obvious desaturation if seen are also recorded.
    


Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients undergoing lomber spinal surgery will be sected
Effects of Milk Protein and Vitamin D on Children's Growth and Health
Condition: Bone Health; Muscle Function; Cardiometabolic Health; Appetite Regulation
Study type: Interventional

Summary: 
      The purpose of D-pro is to investigate the combined and separate effects of milk protein and
      vitamin D on bone health, growth, muscle function, body composition and cardiometabolic
      health in 6-8-year-old children.
    

Detailed description: 
      The D-pro study investigates the effects of high or medium intakes of milk protein, and
      vitamin D supplements or placebo, in healthy 6-8 year-old Danish children. The study is a
      2×2-factorial randomized controlled trial with 4 study arms. The subjects will be randomly
      allocated to receive yoghurt products with either high or medium protein content (300g/day, 6
      days/week) and to receive tablets with either vitamin D (20 μg/day) or placebo for 24 weeks.
      Measurements and biological sampling will be performed at baseline and at the end of the
      intervention.

      The primary outcome will be bone mineral density (BMD). The investigators will also measure
      effects on children's muscle function, cardiometabolic health, body composition, growth and
      growth factors, nutrient status, immune defence and risk of acute respiratory tract
      infections, as well as appetite hormones. The investigators will also assess potential
      sex-specific effects and the potential modifying effect of genotype.
    

Intervention name(s): Milk Protein (high); Vitamin D; Milk Protein (medium)
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): High protein yoghurt which contains approx. 10 g protein per 100 g. Participants will be asked to consume 300 g (=3 dl) 6 days a week.; One daily tablet containing 20 μg of vitamin D3, cholecalciferol.; Ordinary yoghurt containing approx. 3.3 g protein per 100 g. Participants will be asked to consume 300 g (=3 dl) 6 days a week.
Intervention MeSH terms: Vitamin D; Caseins
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Child Nutrition; Dietary recommendations; Milk protein; Vitamin D; Bone mineral density; Muscle strength; Immune defence
Efficacy and Safety of Repaglinide and Metformin Combined in Type 2 Diabetes
Condition: Diabetes; Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 4

Summary: 
      This trial is conducted in Asia. The aim of this trial is to investigate the efficacy of
      blood glucose control with combination therapy of repaglinide and metformin compared to
      conventional treatment with a sulphonylurea or metformin in monotherapy in type 2 diabetes
    


Intervention name(s): repaglinide; metformin; glicazide
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: Metformin; Repaglinide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Evoke Radiofrequency Device for Improvement of Skin Appearance
Condition: Improvement of Skin Appearance
Study type: Interventional

Summary: 
      The aim of the study is to evaluate the safety, efficacy, patient comfort and patient
      satisfaction after Evoke treatment
    


Intervention name(s): Evoke Device
Intervention type(s): Device
Intervention description(s): Subjects will undergo treatment with Evoke Device
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
An fMRI Study on Temporal Discounting in Bipolar Disorder
Condition: Bipolar Disorder; Suicidal Ideation; Depression
MeSH terms: Bipolar Disorder; Suicidal Ideation
Study type: Observational

Summary: 
      The investigators propose to explore the link between bipolar disorder, anxiety, and suicide
      by investigating intertemporal discounting in depressed, suicidal patients with bipolar I and
      II disorder who have various levels of anxiety. The investigators will determine the effect
      of anxiety on their intertemporal discounting (small rewards now compared to larger rewards
      later) in a decision-making paradigm and investigate the associated functional neuroanatomy
      using functional magnetic resonance imaging (fMRI).
    

Detailed description: 
      Among the various psychological properties of the decision making process is temporal
      discounting, which is a decrease in the subjective value of a good as a function of the
      amount of and delay to reward. The ability to decide between immediate versus future rewards
      depends on self-control and consideration of the future. We can reconceptualize suicide as
      intertemporal discounting with an interaction between cognition and mood. Someone
      contemplating suicide weighs the time value of costs and benefits with shifting negative and
      positive valence systems. To the best of our knowledge, no one has assessed the interaction
      between mood symptoms, anxiety, and their impact on the temporal discounting paradigm in
      bipolar patients. If we better understood the difference between anxious, suicidal and
      non-anxious, suicidal bipolar patients, we could design more effective interventions to
      prevent this tragic outcome. We propose a novel paradigm to explore the link between bipolar
      disorder, anxiety, and suicide. If we conceptualize suicidal behavior and death by suicide as
      decisions, then it makes sense to examine key aspects of decision making in these patients.
      In particular, we can examine how mood, anxiety, and suicidal ideation and behaviors arise
      from patterns of decision making, along with neural correlates of decision-making, as
      assessed with fMRI.
    

Intervention name(s): fMRI Scanning
Intervention type(s): Other
Intervention description(s): Imaging will be performed on a 3T Siemens Trio scanner. Each MRI scanning session will last no more than 90 minutes. fMRI will be used to determine brain activation and differences in intertemporal discounting.
Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        We will recruit 30 currently depressed patients (with DSM-IV bipolar I and II disorder who
        are currently or previously suicidal). Enrollment will be limited to adults aged 18-65.
      
Keywords: Magnetic Resonance Imaging; Bipolar Disorder; Suicidal Ideation
Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness
Condition: Lipid Overnutrition; Constitutional Thinness
MeSH terms: Overnutrition; Thinness
Study type: Observational

Summary: 
      For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to
      nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or
      in obese patients by promoting weight gain, either in constitutional thinness (MC) by
      blocking it. The MC is a little known entity. These patients wish to grow for her and others.
      Can they? We have demonstrated abnormalities of hormones regulating appetite (ghrelin, PYY,
      GLP1 and leptin) that may participate in thinness. Furthermore, this thinness is associated
      with osteoporosis in 25% of true MC who is 25 years old.
    

Detailed description: 
      This project aims to overfed MCs and follow the control parameters of energy metabolism. We
      will look for abnormalities in the adaptation to overnutrition in subjects with genetic
      background of thinness, which could explain the resistance to weight gain. The answer could
      possibly help to understand obesity.
    

Intervention name(s): Lipid overnutrition
Intervention type(s): Behavioral
Intervention description(s): During 4 months, the daily caloric intake will be increased by about 70 g fat as butter 20 grams, 100 grams of cheese (Emmental) and 40 grams of almonds. This overnutrition corresponds to an excess of 760 kcal / day or 21,280 calories for the period and then taken to a theoretical 2.4 kg of fat (1 kg fat = 9000 kcal).
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Constitutionnal thinness women and healthy volonteers(women)
      
Biospecimen description: 
      muscle tissue fat tissue
    
Keywords: Thinness; Leanness; healthy volunteers; Lipid metabolism disorder
DSS: Diabetes Surgery Study - Intensive Medical Management of Type 2 Diabetes, With and Without Gastric Bypass Surgery
Condition: Type 2 Diabetes; Cardiovascular Disease
MeSH terms: Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      The present study is the first stage of a research program whose ultimate goal is to conduct
      a randomized clinical trial involving type 2 diabetics with BMI from 30.0 to 39.9 kg/m2. This
      program will determine the relative effectiveness of RYGB combined with intensive medical
      management (IMM), versus IMM alone, in reducing CVD event rates and mortality in patients
      with poorly controlled diabetes. IMM will include rigorous lifestyle modification for weight
      loss and stepped pharmacologic treatment for diabetes and other CVD risk factors. The
      proposed study is a randomized trial which will provide an assessment of the efficacy of
      treatment, in reducing CVD risk factors and also assessing the feasibility, cost, and safety
      of a larger trial.
    


Intervention name(s): intensive medical management; RYGB & IMM
Intervention type(s): Other; Other
Intervention description(s): IMM will include rigorous lifestyle modification for weight loss and stepped pharmacologic treatment consistent with standard of care for diabetes and other CVD risk factors.; Roux-en-Y gastric bypass Surgery combined with intensive medical management
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: T2 Diabetes; Type 2 diabetes CVD event rates and mortality
Aspects Associated With Sleep Quality
Condition: Sleep Bruxism
MeSH terms: Bruxism; Sleep Bruxism
Study type: Observational

Summary: 
      Evaluate the correlation among the diagnostics of sleep bruxism and sleep quality obtained
      from the use of smartphone application (APP-Sleep Cycle®), PSG and questionnaires (Pittsburgh
      Sleep Quality Index-IQSP and Johansson).
    

Detailed description: 
      This study will evaluate the correlation between sleep bruxism and sleep quality diagnoses
      obtained using the application of the smartphone (APP-Sleep Cycle®), polysomnography and
      questionnaires (Pittsburgh Sleep Quality Index-IQSP and Johansson). Subjects (n = 40) between
      19 and 60 years old will be submitted to polysomnography from January to December 2019. The
      questionnaires will be applied before the polysomnography, and the APP will be used together
      with the polysomnography. The data will be tabulated and a descriptive statistical analysis
      performed. Specific statistical tests will be determined after preliminary analysis of the
      data (α = 0.05).
    

Intervention name(s): Pittsburgh Sleep Quality Index (IQSP) and Johansson; Smartphone APP; Polysomnography
Intervention type(s): Diagnostic Test; Diagnostic Test; Diagnostic Test
Intervention description(s): All participants will to answer the Pittsburgh Sleep Quality Index (IQSP) and Johansson questionnaires before polysomnography examination and use of APP.; All study participants will use a smartphone application (APP), which will be made available by the researchers, at the same time as the polysomnography exam.; All participants slept for one night in a sleep laboratory for PSG recording. The data will be confirmed by an otorhinolaryngology certified by the Brazilian Association of Sleep Disorders
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        All adults (aged 20 to 60 years) and elderly (aged > 60 years) who had undergone PSG at the
        Pelotas Sleep Institute (ISP), a private medical out patients clinic, from January to
        December 2019, will be invited to participate in the study.

        Eligibility criteria includ adequate cognitive capacity to understand and answer the
        questionnaire. Written consent will be given by all participants who agreed to participate
        in the study.
      
Keywords: Sleep bruxism; Sleep; Sleep hygiene
Comparison of Preincisional Infiltrated Dexmedetomidine and Lidocaine Plus Adrenaline for Nasal Sephoplasty Surgery.
Condition: Surgery; Pain
Study type: Interventional
Phase: Phase 4

Summary: 
      It is very important to decrease the bleeding during nasal septoplasty in order to increase
      the visibility of the surgical site. Our primary goal was to investigate the effects of
      dexmedetomidine and lidocaine plus adrenaline on visibility of surgical site and
      postoperative analgesic consumption.
    

Detailed description: 
      Nasal septoplasty is a surgery procedure which needs to have decrease the bleeding during the
      surgery for the visibility of surgical site.And postoperative pain is very usual after the
      surgery, so an effective postoperative analgesia procedure reduces the complications and
      helps to be discharged earlier from the hospital. An alpha 2 agonist Dexmedetomidine has an
      analgesic effect and vasoconstructive effect on the periferal blood vessels. Our hypothesis
      was dexmedetomidine makes a better surgecal conditions during the surgery and reduce the
      postoperative analgesic consumption. We administered the infiltrated dexmedetomidine or
      lidocaine plus adrenaline to the both side of the nasal septum 10 minutes before the surgery.
      Bleeding scores (Fromm and Boezaart Bleeding Scores) were recorded during the surgery. And
      postoperative analgesic consumptions were recorded in first 24 hours after the surgery.
    

Intervention name(s): Dexmedetomidine; Lidocaine; Adrenaline
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 2 mcg/kg dexmedetomidine was administered 10 minutes before the surgery by infiltration to the both side of the nasal septum.; 10 ml 2% lidocaine was administered 10 minutes before the surgery by infiltration to the both side of the nasal septum.; 12.5 mcg/ml 10 ml adrenaline was administered 10 minutes before the surgery by infiltration to the both side of the nasal septum.
Other intervention name(s): Precedex; Jetokain %2; Adrenalin; Epinefrin
Intervention MeSH terms: Lidocaine; Epinephrine; Racepinephrine; Dexmedetomidine; Epinephryl borate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Septoplasty, Dexmedetomidine, Surgical Conditions
Ultrasound and Peripheral Nerve Stimulator Guided Femoral Nerve Block
Condition: Spinal Cord Injuries
MeSH terms: Spinal Cord Injuries
Study type: Interventional

Summary: 
      A pre-post descriptive study was performed to examine the immediate effects of ultrasound
      (US) guided femoral nerve block with phenol (UGFNBwP) in managing lower limb spasticity of
      individuals with traumatic spinal cord injury (SCI).
    

Detailed description: 
      Study Design: A pre-post descriptive study was performed. Objectives: To examine the
      immediate effects of ultrasound (US) guided femoral nerve block with phenol (UGFNBwP) in
      managing lower limb spasticity of individuals with traumatic spinal cord injury (SCI).

      Setting: Ankara, Turkey Methods: Nineteen patients with traumatic SCI presenting with lower
      extremity spasticity were treated with UGFNBwP. Modified Ashworth Scale (MAS) of hip flexion
      and knee extension, functional independence measure (FIM) motor subscale, difficulty of
      catheterization (DoC), hygiene score (HS), spasm frequency (SF), sleep quality (SQ) and
      patient satisfaction (PS) were measured in all patients prior to treatment, at first week and
      second month.
    

Intervention name(s): Femoral nerve block with phenol
Intervention type(s): Other
Intervention MeSH terms: Phenol
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: nerve block