bioihbjkbjnl/mcl2 huggingface dataset:
Adipokines and Ghrelin Concentrations in Different Stages of Anorexia Nervosa
Condition: Anorexia Nervosa; Adipokines
MeSH terms: Anorexia; Anorexia Nervosa
Study type: Observational

Summary: 
      The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and
      ghrelin in different stages of anorectic patients and to evaluate their relationships between
      biochemical, hormonal and anthropometric parameters.
    

Detailed description: 
      Objective: The aim of this study is to determine serum concentrations of adiponectin (ApN),
      leptin and ghrelin in different stages of anorectic patients and to evaluate their
      relationships between biochemical, hormonal and anthropometric parameters.

      Design: The study group is composed of four groups. Group1: Treatment-naïve patients with a
      recent diagnosis of AN (n:19), Group 2: The weight recovered (10 % increase in body weight
      compared with baseline weight) subgroup of group 1 at the end of a mean 117.72±98.14 days of
      follow-up (n: 12), Group 3: Recovered patients with a previous history of AN but normal
      menstrual cycles and body weight at the present time (n:10), Group 4: Control group:
      constitutionally thin healthy young women with normal menstrual cycles (n:10). Venous blood
      was obtained for measurements of biochemical parameters, ApN, leptin and ghrelin and body
      composition was determined by bioimpedance analysis.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with anorexia nervosa and constitutionally thin healthy subjects
      
Keywords: Anorexia nervosa; Adipokines; Ghrelin; Fat mass
Long-Term Safety and Efficacy Evaluation of EPI-743 in Children With Leigh Syndrome
Condition: Leigh Syndrome
MeSH terms: Leigh Disease; Syndrome
Study type: Interventional
Phase: Phase 2

Summary: 
      EPI-743 in Leigh syndrome participants that participated in previous EPI743-12-002
      (NCT01721733) study.
    

Detailed description: 
      To monitor the long-term safety and neurodevelopmental effects of EPI-743 on children who
      complete the EPI743-12-002 placebo-controlled trial.
    

Intervention name(s): EPI-743
Intervention type(s): Drug
Intervention description(s): EPI-743 100 milligrams/milliliter (mg/mL) oral solution will be administered per dose and schedule specified in the arm.
Other intervention name(s): Vincerinone, Vatiquinone
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Leigh syndrome; Mitochondrial disorders; EPI743; Vincerinone
Radiographic Assessment of Glass Ionomer Restorations With and Without Prior Application of Nano Silver Fluoride in Occlusal Carious Molars Treated With Partial Caries Removal Technique
Condition: Partial Dentin Caries Removal
Study type: Interventional

Summary: 
      eligible teeth will be randomly divided into two groups to be treated with incomplete caries
      excavation (A), where (A1) represents teeth to be treated with application of Nano silver
      fluoride solution on remaining carious dentin prior to final permanent glass ionomer
      restoration application, (A2) represents comparator group to be restored without Nano silver
      fluoride application prior to restoration. Every participant will receive both the
      intervention and control treatment. Image of radiographic density of remaining carious dentin
      will be evaluated using PSP plate at baseline immediately after restoration and after 6
      months after restorative procedures.

      The null hypothesis tested is that application of Nano silver fluoride solution prior to
      glass ionomer restoration will not increase radiopacity of the underlying dentin treated by
      incomplete carious removal technique compared to that of direct glass ionomer restoration
      without prior application of Nano silver fluoride.
    


Intervention name(s): nano silver fluoride solution
Intervention type(s): Other
Intervention description(s): prepared Nano-silver fluoride could have the capability to arrest caries. As its Nano silver particles have an antimicrobial activity against Mutans Streptococci and Lactobacilli; the main pathogens involved in the development of carious lesions. In addition, its fluoride component is well known to enhance remineralization and inhibit bacterial activity. So, Nano silver fluoride could be a promising solution to combat residual bacteria in tooth cavity with effective remineralization potential on remaining carious dentin
Intervention MeSH terms: Fluorides
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: split mouth randomized clinical trial
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Investigation of the Effectiveness of Manual Therapy Plus Cervical Stabilization Exercise in Chronic Neck Pain
Condition: Neck Pain
MeSH terms: Neck Pain
Study type: Interventional

Summary: 
      This study aims to investigate the effectiveness of manual therapy plus cervical
      stabilization exercise compared to manual therapy alone on balance, proprioception, and neck
      muscle morphology in chronic neck pain.
    

Detailed description: 
      Neck pain is defined as pain and/or stiffness localized to the dorsal area of the area
      between the condyle of the occiput and the third thoracic vertebra. Chronic neck pain (CNP),
      defined as persistent pain lasting three or more mounts, causes disability and a reduction in
      life quality. Balance disorders or postural instability, a deficit in proprioception, changes
      in muscle recruitment, a decrease in dimension of deep cervical muscle, and an increase in
      stiffness of superficial neck muscle may lead to pain in patients with CNP. Both manual
      therapy and exercise have favorable effects on management with CNP. According to our
      knowledge, no study has investigated the effects of manual therapy plus cervical
      stabilization exercise on balance, proprioception, and neck muscle morphology in CNP, yet.
    

Intervention name(s): Manual Therapy; Cervical Stabilazation Exercise (CSE)
Intervention type(s): Other; Other
Intervention description(s): Cyriax's mobilization techniques will be applied as manual therapy. Before the mobilization, soft tissue mobilization techniques will be applied to relieve muscular spasm and preventing the patient' s anxiety. Bringing, manual traction, manual traction with rotation, manual traction with anterior-posterior gliding and lateral gliding mobilization techniques will be applied. Appropriate mobility techniques will be selected according to the complaints and symptoms of the patients. Cervical mobilization applications will take an average of 15-20 minutes.; The CSE program aims to maintain a neutral spine position and activate deep cervical muscles during exercises. It is performed in stages with gradual progression according to the stages of motor learning and sensory-motor integration, namely, static, dynamic, and functional. The program will start with postural training and then the cervical bracing technique with the activation of deep neck flexors for CSE was performed. The patients will be asked to maintain a neutral spine during the exercises and throughout the day as much as possible. The difficulty and variety of exercises will be increased weekly. It will be carried out 2 days a week for 6 weeks (12 sessions) by the supervisor physiotherapist.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants were randomly assigned to manual therapy plus cervical stabilization exercise group (intervention group) and only the manual therapy group (control group).
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: neck pain; manual therapy; exercise; postural control
Radiation Dose Escalation in Esophageal Cancer
Condition: Esophageal Cancer
MeSH terms: Esophageal Neoplasms
Study type: Interventional

Summary: 
      The aim of this trial is to find the maximum tolerable dose of radiation that can be
      delivered combined with chemotherapy (DDP & Paclitaxel) in patients with inoperable or
      medically unresectable esophageal cancer.
    

Detailed description: 
      The RTOG 8501 has established concurrent radiochemotherapy as the standard of care for cancer
      of the esophagus.However, locoregional remain problematic, with 25% of patients having
      persistence and 20% relapse of locoregional disease following the combined modality approach.
      New regimen is urgently needed for improving localregional control and survival.
    

Intervention name(s): radiochemotherapy 1; radiochemotherapy 2; radiochemotherapy 3; radiochemotherapy 4; radiochemotherapy 5; radiochemotherapy 6
Intervention type(s): Radiation; Radiation; Radiation; Radiation; Radiation; Radiation
Intervention description(s): concurrent radiochemotherapy: radiotherapy dose level 1: 50 Gy at 2 Gy/Fx/d, then 7.2 Gy at 1.2 Gy/Fx/bid; concurrent chemotherapy: carboplatin, area under the curve (AUC) 1.5-2, weekly; paclitaxel, 45-50 mg/m2, weekly; concurrent radiochemotherapy: radiotherapy dose level 1: 50 Gy at 2 Gy/Fx/d, then 14.4 Gy at 1.2 Gy/Fx/bid; concurrent chemotherapy: carboplatin, area under the curve (AUC) 1.5-2,weekly; paclitaxel, 45-50 mg/m2, weekly; concurrent radiochemotherapy: radiotherapy dose level 1: 50 Gy at 2 Gy/Fx/d, then 21.6 Gy at 1.2 Gy/Fx/bid; concurrent chemotherapy: carboplatin, area under the curve (AUC) 1.5-2,weekly; paclitaxel, 45-50 mg/m2, weekly; concurrent radiochemotherapy: radiotherapy dose level 1: 50 Gy at 2 Gy/Fx/d, then 28.8 Gy at 1.2 Gy/Fx/bid; concurrent chemotherapy: carboplatin, area under the curve (AUC) 1.5-2,weekly; paclitaxel, 45-50 mg/m2, weekly; concurrent radiochemotherapy: radiotherapy dose level 1: 50 Gy at 2 Gy/Fx/d, then 36 Gy at 1.2 Gy/Fx/bid; concurrent chemotherapy: carboplatin, area under the curve (AUC) 1.5-2,weekly; paclitaxel, 45-50 mg/m2, weekly;; concurrent radiochemotherapy: radiotherapy dose level 1: 50 Gy at 2 Gy/Fx/d, then 43.2 Gy at 1.2 Gy/Fx/bid concurrent chemotherapy: carboplatin, area under the curve (AUC) 1.5-2,weekly; paclitaxel, 45-50 mg/m2, weekly
Other intervention name(s): concurrent chemoradiotherapy regimen; concurrent chemoradiotherapy regimen; concurrent chemoradiotherapy regimen; concurrent chemoradiotherapy regimen; concurrent chemoradiotherapy regimen; concurrent chemoradiotherapy regimen
Allocation: Non-Randomized
Intervention model: Sequential Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Study of Time to Pregnancy in Normal Fertility
Condition: Fertility; Pregnancy
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine how long it takes couples of normal fertility to
      get pregnant once they begin to try, and whether instruction in fertility awareness can
      decrease time to pregnancy in these couples.
    

Detailed description: 
      Research has established that there are relatively few days of the menstrual cycle that have
      a substantial probability of pregnancy from coitus, and that there are prospective biomarkers
      that allow a woman or couple to identify these "fertile" days. However, it remains unclear
      how this knowledge may improve a couple's chances of conceiving.

      All couples participating in this study must have a history of previous pregnancy together
      and no history suggesting subfertility. Participants in this study will be randomly assigned
      to one of two groups. One group will receive instruction about identifying the days when a
      woman is mostly likely to get pregnant from intercourse, using the Creighton Model
      FertilityCare System, and the other group will receive instructions about the menstrual
      cycle, fertility, and preparing for pregnancy. Randomization is stratified by age.

      All participants will keep a daily fertility chart and use a computerized device called the
      Fertility Monitor with urine dipsticks to monitor hormones of the menstrual cycle.

      The primary outcome is time to pregnancy.
    

Intervention name(s): Instruction in the Creighton Model Fertility Care System; Preconception advice
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Instruction in the Creighton Model Fertility Care System.; Preconception advice for diet and frequency of intercourse.
Other intervention name(s): Fertility awareness instruction.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Keywords: fertility; pregnancy
Efficacy and Safety of E.Coli Nissle 1917 in Patients With Mild (Stage 1-2) or Minimal Hepatic Encephalopathy
Condition: Hepatic Encephalopathy; Liver Cirrhosis; End Stage Liver DIsease
MeSH terms: Liver Diseases; Liver Cirrhosis; Hepatic Encephalopathy; End Stage Liver Disease; Brain Diseases; Fibrosis
Study type: Interventional

Summary: 
      The purpose of study to assess the short-term efficacy and safety of probiotic E.coli Nissle
      1917 strain comparing to lactulose and rifaximin in patients with mild (Stage 1-2) or minimal
      hepatic encephalopathy
    


Intervention name(s): E.coli Nissle 1917; Lactulose; Rifaximin
Intervention type(s): Dietary Supplement; Drug; Drug
Intervention description(s): Probiotic contains biomass of E.coli Nissle 1917, 2,5-25·109 colony forming units - CFU/g; will receive 30-60 ml of lactulose in 2 or 3 divided doses so that patient passed 2-3 semisoft stools per day, 1 months of treatment; rifaximin, oral, 500 mg BID, 1 months of treatment
Other intervention name(s): MUTAFLOR capsules; DUPHALAC; Alfa Normix
Intervention MeSH terms: Rifaximin; Lactulose
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: hepatic encephalopathy; Liver Cirrhosis; End Stage Liver DIsease; E.coli Nissle 1917; Probiotic; lactulose; rifaximin
Anti-Interleukin-5 (IL-5) Study for Hypereosinophilic Syndrome
Condition: Hypereosinophilic Syndromes; Eosinophilic Gastroenteritis; Churg-Strauss Syndrome; Eosinophilic Esophagitis
MeSH terms: Esophagitis; Gastroenteritis; Eosinophilic Esophagitis; Churg-Strauss Syndrome; Hypereosinophilic Syndrome; Syndrome
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Toxicity of anti-IL-5
    

Detailed description: 
      The purpose of the study is to assess the toxicity of anti-IL-5, and to see whether it lowers
      peripheral blood eosinophils and/or tissue and whether it has a steroid and/or interferon
      sparing effect.
    

Intervention name(s): Mepolizumab
Intervention type(s): Drug
Intervention description(s): 10mg/kg (max 750 ml) once a month for 3 months
Other intervention name(s): Anti-IL5
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Lamotrigine Cognitive Function Study in Adult Untreated Epilepsies
Condition: Epilepsy
MeSH terms: Epilepsy
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to compare the effect of anti-epileptic drugs' (AEDs) long-term
      treatment on cognitive function. This study is an open-label, randomized, multicenter
      comparative trial of lamotrigine versus carbamazepine. The planned enrollment is 100
      patients.
    


Intervention name(s): lamotrigine (Lamictal); Carbamazepine (Tegretol)
Intervention type(s): Drug; Drug
Intervention description(s): lamotrigine: titration for 8 weeks (25 mg~200 mg per 2 weeks) and maintenance for 40 weeks (200 mg); Carbamazepine: titration for 8 weeks (100 mg~600 mg) and maintenance for 40 weeks (600 mg)
Other intervention name(s): lamictal; Tegretol
Intervention MeSH terms: Lamotrigine; Carbamazepine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Epilepsy; lamotrigine; cognitive function
Rapid On-site Cytopathologic Evaluation in the Diagnosis of Hilar/Mediastinal Adenopathy
Condition: Lung Cancer; Sarcoidosis; Tuberculosis
MeSH terms: Tuberculosis; Sarcoidosis; Lymphadenopathy
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether rapid on-site cytopathologic evaluation
      (ROSE) can increase the diagnostic yield of transbronchial needle aspiration (TBNA) in the
      diagnosis of hilar and mediastinal lymphadenopathy.
    


Intervention name(s): Rapid on-site cytopathologic evaluation (ROSE); TBNA
Intervention type(s): Procedure; Procedure
Intervention description(s): ROSE: examination in the endoscopy suite, by a pathologist, during the bronchoscopic procedure, of samples obtained with transbronchial needle aspiration.; transbronchial needle aspiration
Allocation: Randomized
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Transbronchial needle aspiration; Bronchoscopy; Rapid on-site cytopathologic evaluation; Mediastinal lymphadenopathy; Hilar Lymphadenopathy
Study of GSK1358820 In Patients With Post-Stroke Lower Limb Spasticity
Condition: Post-Stroke Spasticity; Cerebrovascular Accident
MeSH terms: Muscle Spasticity; Stroke
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a study to confirm the superior efficacy of GSK1358820 over placebo in patients with
      equinus deformity associated with post-stroke lower limb spasticity using the Modified
      Ashworth Scale (MAS) ankle score.
    

Detailed description: 
      This is a study to confirm the superior efficacy of GSK1358820 over placebo in patients with
      equinus deformity associated with post-stroke lower limb spasticity using the Modified
      Ashworth Scale (MAS) ankle score.
    

Intervention name(s): GSK1358820; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): botulinum toxin type A; Placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Post-Stroke; Lower Limb; botulinum toxin type A; Spasticity
A Double Blind Open Label Comparator Study to Compare Treatments in 4 to 11 Year Old Patients With Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of the study is to characterize the pharmacokinetic profiles of fluticasone
      propionate and/or salmeterol when delivered as a single oral inhalation dose of Fp MDPI and
      FS MDPI.
    


Intervention name(s): Fluticasone Propionate MDPI; Fluticasone Propionate/Salmeterol MDPI; Fluticasone propionate/salmeterol
Intervention type(s): Drug; Drug; Drug
Other intervention name(s): Fp MDPI; FS MDPI; ADVAIR; DISKUS
Intervention MeSH terms: Fluticasone; Xhance; Salmeterol Xinafoate; Fluticasone-Salmeterol Drug Combination
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Functional Electrical Stimulation On Functional Rehabilitation In Children With Erb's Palsy
Condition: Erb's Palsy
MeSH terms: Brachial Plexus Neuropathies
Study type: Interventional

Summary: 
      Erb's palsy is a type of brachial plexus injury occurs in infants due to injury of nerves
      during childbirth. Injury causes weakness or paralysis of different muscles. Different type
      of approaches are made for the treatment of erb;s palsy such passive range of motion,
      stretching ,splinting ,electrotherapy etc. In erb's palsy the most affected ranges are
      shoulder abduction and shoulder external rotation. Quasi experimental study will be done on
      the patient with erb's palsy intervention applied will be functional electrical stimulation
      (a low frequency current) applied 5 day a weeks for 2 weeks than on alternate days for the
      rest of the treatment. Setting for functional electrical stimulation will be Frequency 20 pps
      with Pulse width of 300 msec. 18 patient will be recruited . "Assumed population standard
      deviation"4.24" "Confidence level""0.95" "Acceptable error""2". Pre-intervention reading will
      be taken on modified mallet scale and universal goniometer and post intervention measurement
      will be taken after 02, 04 ,06 months.
    


Intervention name(s): Functional Electrical Stimulation
Intervention type(s): Other
Intervention description(s): functional electrical stimulation with Frequency 20 pps with Pulse width of 300 msec.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Effectiveness of a Home Rehabilitation Program vs an e-Health Program in Patients With Chronic Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      The main objetive of this study is to analyze the effectiveness of a home rehabilitaton
      program vs a e-Health program. Therapeutic approach will be by electroanalgesia and exercise
      of patients with chronic low back pain.
    

Detailed description: 
      A double blind clinical trial will be developed in a sample of 80 subjects with chronic low
      back pain. Patients will receive 3 weekly sessions of electroanalgesia and an exercise
      program for 8 weeks, for a total of 24 sessions. The aim is to analyze the effectiveness of a
      home rehabilitation program vs a web platform program on disability, pain, fear of movement,
      quality of life, resistance of the trunk flexors, lumbar mobility in flexion and muscular
      electrical activity.
    

Intervention name(s): Home Rehabilitation Program; e-Health program
Intervention type(s): Other; Other
Intervention description(s): It consists in a home rehabilitation program performing electroanalgesia and an exercise program following the Mckenzie method. Patients will be instructed in the use of the TENS device using 5x9cm electrodes at the bilateral paravertebral level, the patients that present radicular pain, the electrodes will be placed in the path of the affected nerve. The realization of exercises will be through the application of an Mckezie protocol. The duration will be the same as that used to carry out the Mckenzie protocol. Mckenzie exercises are designed to make changes in the internal components periarticular of the spine.; It consists in an e-Health rehabilitation program through a web platform performing electroanalgesia and an exercise program following the Mckenzie method. Patients will be instructed in the use of the TENS device using 5x9cm electrodes at the bilateral paravertebral level, the patients that present radicular pain, the electrodes will be placed in the path of the affected nerve. The realization of exercises will be through the application of an Mckezie protocol. The duration will be the same as that used to carry out the Mckenzie protocol. Mckenzie exercises are designed to make changes in the internal components periarticular of the spine.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Low back pain; Electroanalgesia; Exercise program; Randomized clinical trial