bioihbjkbjnl/mcl2 huggingface dataset:
Intrauterine Insemination Predictor Factors
Condition: Infertility
MeSH terms: Infertility
Study type: Observational

Summary: 
      Multiple studies have reported on the impact of factors such as female age, duration of
      infertility, type of infertility, hormone levels (i.e. AMH, FSH, estradiol, progesterone),
      use of different ovarian stimulation protocols, timing/induction of ovulation, number of
      pre-ovulatory follicles, endometrial thickness by the time of ovulation, sperm parameters
      (i.e. concentration, progressive motility, morphology, total motile sperm count [TMSC],
      inseminating motile count [IMC]) and sperm washing procedures. Also the influence of body
      mass index and smoking on IUI outcome have been studied before. However, results on the
      predictive value of these parameters remain highly contradictory. The aim of the study is to
      examine the value of different variables in the prediction of IUI success to develop a
      clinically useful predictive model of pregnancy and live birth.
    


Intervention name(s): Homologous intrauterine insemination (IUI)
Intervention type(s): Procedure
Intervention description(s): Patients were treated with HMG/rFSH according to classic protocols of therapy and monitoring. An injection of uHCG 5000 IU/ rHCG 250 mg was given to trigger ovulation. On the day of insemination, the semen sample was obtained through masturbation after a 2-5 day abstinence period and collected in a sterile cup. TMSC was determined by multiplying grade A or grade A + B sperm motility percentages by sperm volume and concentration. To evaluate sperm viability Eosin and Nigrosin (E&N) staining was carried out according to WHO standards. Sperm capacitation was performed using density gradient centrifugation or swim-up procedure in order to remove seminal fluids and enhance sperm quality for IUI.
IUI was performed a t36 hours post-HCG. A fraction of the washed motile spermatozoa was inserted up to the uterine fundus and expelled into the uterine cavity. Daily treatment with micronized progesterone was prescribed for 14 days after IUI. Serum ß-HCG was determined 14 days after IUI.
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        The included couples were subjected to an infertility diagnostic work-up. The tests
        included collecting medical history, physical examination, transvaginal ultrasound, serum
        hormone assays between day 2 and 4 of the menstrual cycle, semen analysis, uterine cavity
        and tubal patency evaluation with hysterosalpingography (HSG) or hysterosonosalpingography
        (HSSG) and/or hysteroscopy and video laparoscopy. Assessment of vaginal infection with
        cervico-vaginal swab and cultures
Heart Transplant Registry of Városmajor
Condition: Disorder Related to Cardiac Transplantation
Study type: Observational [Patient Registry]

Summary: 
      The purpose of this registry is to determine the long term outcomes of heart transplantations
      performed at the Semmelweis University Heart and Vascular Center. All eventual interventional
      and non-interventional procedures will be accounted for and summarized.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Heart transplant recipient, cared for by the Semmelweis University Heart and Vascular
        Center
      
Biospecimen description: 
      Blood samples
    
Keywords: Heart transplant; Cardiac allograft vasculopathy; Chronic rejection; Immunosuppressant therapy
Continuous Central Venous Lactate Monitoring by Intravascular Microdialysis : a Comparison to Sequential Arterial Lactate Measurement During Shock.
Condition: Shock
MeSH terms: Shock
Study type: Observational

Summary: 
      During shock, arterial hypotension, inadequate cardiac output and microcirculatory
      alterations lead to tissue hypoxia, multiple organ failure and death. Arterial lactate is
      considered as the best marker of tissue hypoxia. A lactate decrease during the first 6 hour
      is strongly associated with better outcome and may be used as a target for assessing the
      efficiency of shock resuscitation.

      The EIRUS system (Maquet Critical Care AB, 17154, Solna, Sweden) is a new device allowing the
      continuous measurement of venous lactate through a central venous catheter.

      However, before being used extensively, such device needs to be evaluated concerning its
      accuracy. The aim of the present study is to assess the reliability of this device.
    


Intervention name(s): EIRUS system (Maquet Critical Care AB, 17154, Solna, Sweden)
Intervention type(s): Device
Intervention description(s): continuous measurement of venous lactate through a central venous catheter by microdialysis
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        ICU patients
      
Keywords: Lactic Acid
A Study Evaluating the Safety, Tolerability, and Initial Efficacy of Recombinant Human Anti-T-cell Immunoreceptor With Ig and ITIM Domains (TIGIT) Monoclonal Antibody Injection (IBI939) in Subjects With Advanced Malignant Tumors
Condition: Advanced Malignancies
MeSH terms: Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      This is an open-label, dose escalation, Phase I study to evaluate the safety, tolerability,
      pharmacokinetics and efficacy of IBI939 in subjects with advanced malignancies
    


Intervention name(s): IBI939; IBI939+ Sintilimab; IBI939+ Sintilimab
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Several dose levels will be evaluated for IBI939 administered as a single agent and in combination with Sintilimab. IBI939 will be given via intravenous (IV) infusion on Day 1 of each 21-day cycle until disease progression or loss of clinical benefit. Those who discontinue treatment with single-agent IBI939 may receive combination treatment with Sintilimab or IBI939+ Sintilimab. Combination treatment may continue until disease progression or loss of clinical benefit.; IBI939: Several dose levels will be evaluated for IBI939 in combination with Sintilimab. IBI939 will be given via intravenous (IV) infusion on Day 1 of each 21-day cycle until disease progression or loss of clinical benefit.
Sintilimab: Sintilimab will be given as 200 mg via IV infusion on Day 1 of each 21-day cycle in combination with IBI939. Combination treatment may continue until disease progression or loss of clinical benefit.; IBI939: IBI939 in combination with Sintilimab will be given with RP2D. IBI939 will be given via intravenous (IV) infusion on Day 1 of each 21-day cycle until disease progression or loss of clinical benefit.
Sintilimab: Sintilimab will be given as 200 mg via IV infusion on Day 1 of each 21-day cycle in combination with IBI939. Combination treatment may continue until disease progression or loss of clinical benefit.
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Allurion Digital Behaviour Change Intervention
Condition: Obesity
Study type: Interventional

Summary: 
      The proposed study is a prospective, non-randomized, pilot study to test the impact of the
      Allurion Digital Behaviour Change Intervention (DBCI) in participants who have been treated
      with the Allurion™ Gastric Balloon System. The study will include a nested qualitative and
      quantitative evaluations of the intervention from both the participant and Allurion provider
      perspective.
    

Detailed description: 
      The study consists of the following:

        -  Screening and enrolment period (prior to or day of Allurion Gastric Balloon System
           treatment)

        -  All participants will take part in the Allurion DBCI for 6 months following study
           enrolment

        -  All participants will complete a 6-month follow-up assessment after completion of the
           Allurion DBCI
    

Intervention name(s): Allurion Digital Behaviour Change Intervention
Intervention type(s): Device
Intervention description(s): The Allurion DBCI adheres to current National Institute for Health and Care Excellence (NICE) guidance for obesity.
Intervention model: Single Group Assignment
Intervention model description: Prospective Single Arm Cohort Pilot Study
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Intragastric balloon
Oral Hygiene Procedures on Reduction of Oral Malodor
Condition: Halitosis
MeSH terms: Halitosis
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of the study is to evaluate the effect of various oral hygiene procedures on
      reduction of oral malodor.
    

Detailed description: 
      Thirty volunteers who matched with including criteria were divided randomly into two groups.
      Both groups were instructed to brush their teeth with a scrubbing method for the first one
      week. Then, each group received the different additional oral malodor reduction regimen- in
      addition to tooth brushing tongue cleaning in one group and chlorine dioxide (ClO2) mouthwash
      in another group for three consecutive weeks. After that, all the participants were
      instructed to practice all the three oral hygiene procedures (tooth brushing, mouth washing,
      tongue cleaning) the last one week. Total volatile sulfur compounds (VSCs) measured by
      breathtron, tongue coating, plaque score and bleeding on probing (BOP) were outcomes of this
      study.
    

Intervention name(s): group 1: drug: chlorine dioxide; group 2: device: small tooth brush for tongue cleaning
Intervention type(s): Drug; Device
Intervention description(s): First, each group practiced tooth brushing only for one week. After that each group was requested to do the following procedures.
group 1 - additional use of 12ml chlorine dioxide (ClO2) mouthwash two times per day, for three consecutive weeks besides tooth brushing.
At last, each group practiced all three methods of tooth brushing, tongue cleaning, mouth washing.; First, each group practiced tooth brushing only for one week. After that each group was requested to do the following procedures.
group 2 - additional practice of tongue cleaning by a small tooth brush two times per day, for three consecutive weeks besides tooth brushing.
At last, each group practiced all three methods of tooth brushing, tongue cleaning, mouth washing.
Other intervention name(s): ClO2Fresh®
Intervention MeSH terms: Chlorine dioxide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Prevention
Keywords: halitosis; chlorine dioxide; tongue cleaning
18751-Sun Protection Factor Assay.
Condition: Sunscreening Agents
Study type: Interventional

Summary: 
      To evaluate the Sun Protection Factor (SPF) efficacy on human skin.
    


Intervention name(s): Coppertone(BAY987517)
Intervention type(s): Drug
Intervention description(s): Each 50 cm*2 test site area of a subject requires 100 mg of a test material to obtain a standard 2 mg/cm*2 test application.Formulation number - SR16-02.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Physical Activity and Neuropsychological Outcomes in a Cancer Population
Condition: Cognitive Dysfunction; Breast Cancer Survivors
MeSH terms: Cognitive Dysfunction
Study type: Interventional

Summary: 
      Many cancer survivors experience treatment-related impairments in mental abilities such as
      memory, attention, and concentration (known as cognition). Research indicates that physical
      activity can improve cognition in healthy adults; however, little is known about whether
      physical activity can improve cognition among cancer survivors. This study will test whether
      a physical activity intervention results in improvements in cognition among breast cancer
      survivors, which may lead to interventions to improve cognition.
    


Intervention name(s): Exercise; Control
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Primary purpose: Treatment
Influence of DM on Artery Blood Flow and Complications After Radial Artery Cannulation
Condition: End Stage Renal Disease
MeSH terms: Kidney Diseases; Kidney Failure, Chronic
Study type: Interventional

Summary: 
      In atherosclerotic patients undergoing kidney transplantation, arterial cannulation is
      commonly performed for continuous monitoring of systemic blood pressure and intermittent
      assessment of arterial blood gases. The radial artery is the preferred artery, because of its
      well-documented low complication rate and easy access, but, radial artery cannulation is may
      associated with complications. Atherosclerosis is a systemic phenomenon, and structural
      changes attributable to atherosclerosis, such as luminal narrowing, intimal hyperplasia, and
      reduction in distensibility occur frequently throughout the arterial tree. Especially in
      patients with diabetes mellitus (DM), the radial artery is prone to atherosclerosis and
      perhaps calcification. In a recent study, it was found that the radial artery flow was
      decreased immediately after cannulation, but recovered to its pre-cannulation value after
      5min, whereas a compensatory increase of blood flow in the ulnar artery occured immediately
      after cannulation, persisting until 5 min. This study enrolled the patients of ASA physical
      status 1-2. In the patients scheduled for elective kidney transplantation, this compensatory
      increase of blood flow in the ulnar artery may not be occurred, because of atherosclerosis,
      particularly in patients with DM. In our study, we found whether there is appropriate
      compensatory increase of blood flow in the ulnar artery after the radial artery cannulation
      in two groups, patients with DM (group DM) or without DM (group nonDM), both undergoing
      elective kidney transplantation.
    


Intervention name(s): duplex Doppler ultrasonography
Intervention type(s): Device
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: diabetes mellitus(DM); radial artery cannulation; artery blood flow; complication; End stage renal disease undergoing kidney transplantation
Open or Laparoscopic Mesolectal Excision in Low Rectum Cancer
Condition: Rectal Cancer
MeSH terms: Rectal Neoplasms
Study type: Interventional

Summary: 
      To compare the open approach and the laparoscopic-assisted approach of dissection of lateral
      lymph nodes in low advanced rectal cancer patients with clinically suspected nodal metastases
      in terms of safety, technical feasibility, and patient's oncological outcomes.
    

Detailed description: 
      the investigators collected data of sixty low advanced cancer rectum patients who underwent
      either laparoscopic (30 cases) or open total mesorectal excision (30 cases) in addition to
      lateral pelvic dissection. The duration of operation in the laparoscopically assisted
      procedure was longer than the open procedure (p=0.003). The postoperative hospital stay time
      was longer in the open group than in the laparoscopic group (P=0.043). No significant
      differences between both groups regarding the number of excised lymph nodes, disease
      recurrence, RFS, or OS rate.
    

Intervention name(s): laparoscopic-assited excision of mesorectum with pelvic lymph nodes excision
Intervention type(s): Procedure
Intervention description(s): We performed laparoscopic dissection of the lateral pelvic lymph node for thirty patients while we performed open lateral pelvic lymph node dissection for the remaining thirty patients.
Performed surgical approaches were abdominoperineal resection, internal sphincter resection, and low anterior resection. All performed surgical procedures included lateral pelvic lymphadenectomy in addition to performing total mesorectal excision.
Choosing whether to perform unilateral or bilateral lymphadenectomy depends on lymph nodes invasion by cancer was on one side or both sides.
Other intervention name(s): open excision of mesorectum with pelvic Lymph nodes excision
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Alcohol, Inflammation and Atherosclerosis
Condition: Arteriosclerosis; Myocardial Infarction
MeSH terms: Myocardial Infarction; Arteriosclerosis; Inflammation; Infarction
Study type: Interventional

Summary: 
      Effect of moderate alcohol consumption in form of red wine, beer and ethanol solution and
      corresponding de-alcoholised beverages on immune measures.

        -  In healthy middle aged men and women

        -  In a randomized controlled cross-over trial

        -  Two intervention periods over 3 weeks
    

Detailed description: 
      Alcohol consumption and mortality from all causes are associated in a U-shaped manner. That
      means that individuals who regularly consume moderate amounts of alcohol (~1 to 2 drinks/day
      at maximum) on average live longer than abstainers or heavy drinkers. This is primarily
      through a reduced risk for fatal or non-fatal coronary heart disease events (CHD) such as
      myocardial infarction. In the last 10 to 15 years compelling evidence has bolstered the
      hypothesis that atherosclerosis is at least in part an inflammatory disease. It is also
      known, that alcohol influences the immune system. These facts make an impact of alcohol on
      the various stages of atherosclerosis via anti-inflammatory effects a reasonable assumption.

      To test the effect of moderate amounts of different types of alcoholic beverages on markers
      of inflammation with high predictive potential for atherothrombotic complications of
      atherosclerosis will be examined in a cross-over short-term interventional trial. Six groups,
      each comprising 12 healthy individuals aged 22-56 will be included. After two weeks of
      abstinence from alcoholic beverages two cross-over interventional phases (each lasting 3
      weeks) with red wine, beer, de-alcoholised red wine and beer of the same brand, ethanol, or
      water will follow. The interventions will be followed by a wash-out period of 2 weeks.
      Several inflammatory markers and in-vitro migration of freshly isolated monocytes will be
      determined before and after intervention.
    

Intervention name(s): red wine, beer, ethanol; de-alcoholised red wine, de-alcoholised beer, water
Intervention type(s): Drug; Drug
Intervention description(s): Alcoholic beverages equivalent to 30g of alcohol per day for men and 20g/d for women for 3 weeks; de-alcoholised red wine, de-alcoholised beer, water
Intervention MeSH terms: Ethanol
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: alcoholic beverages; non-alcoholic beverages; inflammation; Serum concentration of inflammatory markers before and after intervention
Feasibility of Non-pharmacological Insomnia Therapy in People Living With HIV
Condition: Insomnia; Sleep Efficiency
MeSH terms: Sleep Initiation and Maintenance Disorders
Study type: Interventional

Summary: 
      To establish with a prospective randomized placebo-controlled study the feasibility of
      allied-health personnel-administered cognitive behavioral insomnia therapy (CBTI) as a means
      of improving HIV/AIDS treatment adherence.
    


Intervention name(s): Cognitive Behavioral Therapy; Behavioral Modification
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: HAART adherence; HIV; Fatigue; treatment
The Effect of Oxytocin on Gastric Emptying
Condition: Dyspepsia; Lack of Satiety
MeSH terms: Dyspepsia
Study type: Interventional

Summary: 
      The investigators have seen that oxytocin lowers satiety in healthy subjects. Patients with
      dyspepsia suffers from decreased accommodation and increased satiety postprandially. The
      investigators now want to examine whether oxytocin may diminish symptoms in these patients.
    

Detailed description: 
      Patients will come twice for a slow satiety drinking test. Once they will get saline infusion
      and once oxytocin 40 mU/min. At the same time they register satiety on a VAS scale.
    

Intervention name(s): oxytocin
Intervention type(s): Drug
Intervention description(s): 40mU/min as infusion of oxytocin
Other intervention name(s): syntocinon
Intervention MeSH terms: Oxytocin
Intervention model: Single Group Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: oxytocin; satiety; dyspepsia
Neomycin and Rifaximin Plus Neomycin in Treating Methane Positive Constipation Predominant Irritable Bowel Syndrome
Condition: Constipation-predominant Irritable Bowel Syndrome
MeSH terms: Irritable Bowel Syndrome; Syndrome; Constipation
Study type: Interventional

Summary: 
      In this study the investigators aim to compare the efficacy of neomycin to a combination of
      rifaximin and neomycin in the treatment of C-IBS subjects with methane on their breath test.
      This study will be conducted in collaboration with Dr. John DiBaise at the Mayo Clinic in
      Scottsdale, AZ and Dr. Satish Rao in Georgia Regents University in Augusta, GA.
    


Intervention name(s): Neomycin; Placebo; Rifaximin
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 500 mg po bid for 14 days; placebo for 14 days tid; 550 mg po tid
Other intervention name(s): Mycifradin; Neo-Tab; Neo-Fradin; Xifaxan
Intervention MeSH terms: Rifaximin; Neomycin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Constipation predominant Irritable Bowel Syndrome