Evaluation of the Effect of HFMT in Promoting Donor-site Wound Healing
Condition: Wound Heal
MeSH terms: Wounds and Injuries
Study type: Interventional

Summary: 
      Autologous hair transplantation involves follicle extraction, trimming, and implantation.
      Follicle trimming improves efficiency and postoperative appearance, resulting in the
      discarded tissue known as hair follicle-derived microtissue (HFMT). In a clinical case, HFMT
      homogenate was applied to the FUE donor area wound, resulting in reduced pain, relief from
      itching, and faster healing compared to conventional treatment. This study aims to compare
      the effects of HFMT on FUE donor area wound healing.
    

Detailed description: 
      The process of autologous hair transplantation involves three steps: FUE follicle extraction,
      follicle trimming, and follicle implantation. The purpose of follicle trimming is to improve
      the efficiency of follicle implantation and enhance the immediate postoperative aesthetic
      appearance. Therefore, during the follicle trimming process, the sebaceous glands and
      above-mentioned epidermis, partial dermis tissue, and surrounding tissue of the follicles are
      usually separated and discarded, and the remaining follicle tissue is implanted into the
      recipient area. The investigator collectively refers to the discarded tissue as hair
      follicle-derived microtissue (HFMT). In a clinical case, The investigator accidentally
      discovered that if the HFMT obtained from the follicular unit extraction (FUE) method was
      collected, cut into pieces, and made into tissue homogenate, and then the HFMT homogenate was
      used to cover the FUE donor area wound, the patient reported reduced postoperative pain and
      some relief from skin itching. Additionally, compared to conventionally treated wounds, the
      wound in the donor area healed faster. Based on these findings, this study aims to compare
      the effects of HFMT on the healing of FUE donor area wounds.
    

Intervention name(s): HFMT cell suspension; Mupirocin ointment
Intervention type(s): Other; Other
Intervention description(s): Perform FUE autologous hair transplantation on the patient according to the guidelines and standard procedures. During the procedure, a hollow punch is used to individually punch out follicular units from the donor area. The epidermis, some dermis tissue, sebaceous glands, and surrounding tissue of the follicular units are separated and removed before the remaining follicular tissue is implanted into the recipient area. The separated tissue is trimmed with surgical scissors to create a cell suspension. After completion of the procedure, the HFMT cell suspension is evenly applied to the treatment group surface. Double vaseline gauze is used to cover all donor areas and is then wrapped with sterile dry gauze with moderate pressure.; the Minoxidil ointment is evenly applied to the control group surface.
Intervention MeSH terms: Mupirocin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: hair transplantation