Telerehabilitation Cognitive Impairments Following Chemotherapy Usability Study
Condition: Chemotherapy-Related Cognitive Impairment; Healthy
MeSH terms: Chemotherapy-Related Cognitive Impairment; Cognitive Dysfunction
Study type: Observational

Summary: 
      Develop a game-based upper-extremity motor and cognitive rehabilitation system using custom
      and adaptable virtual reality simulations.

      Perform usability study on 2 elderly healthy volunteers and 2 breast cancer survivors with
      lasting cognitive impairments following chemotherapy, so to improve the product design. The
      usability evaluation will be done at NJ Bioscience Center (North Brunswick, NJ).
    

Detailed description: 
      The study will generate data on ease of use of a system for subjects with stage II or stage
      III breast cancer survivors with lasting cognitive impairments subsequent to their first
      chemotherapy regimen. The usability component will uncover technical issues in its usability,
      as well as its rating on perceived usefulness. Data will also be collected on the ease of
      remote monitoring of the subjects by clinicians.

      This portion of the study is intended to provide information pertaining to the usability of
      the experimental system for remote integrative (cognitive and motor) therapy of breast cancer
      survivors (Stage II or III) with lasting chemotherapy related cognitive impairment (CRCI)
      subsequent to first chemotherapy regimen, living in the community.

      Specific aims are:

        1. testing of a added biosensors, new technology acceptance and ease of use at home by
           these individuals;

        2. a caregiver console and enhanced automatic session report that will allow remote
           monitoring of patient exercising and offline data processing and review.

      Participants will each perform 4 usability evaluation sessions. At the end of each session
      participants will fill a custom evaluation form, using 5-point Likert scale scoring. At the
      end of the last session participants will also fill a USE standardized usability evaluation
      form.
    

Intervention name(s): Usability study
Intervention type(s): Other
Intervention description(s): Participants will first be screened for propensity to simulation sickness and for cognitive state using the MoCA evaluation test. Those who passed the screening will perform 4 usability sessions rating the ease of use and perceived benefit of the experimental system and of a caregiver interface laptop. The 2 healthy volunteers will evaluate first, such that issues may be resolved before testing is done on the impaired participants. Each session will be compensated with a $35 payment. During each session participants will play a series of increasing difficulty simulated tasks, aimed to train primarily the executive functions domain. At the end of each session participants will rate their experience using custom subjective evaluation forms with multiple items. Each item will be scored using a 5-point Likert scale. At the end of the 4th session, participants will also fill the USE standardized usability form.
This usability evaluation will be conducted at the NJ Bioscience Center.
Observational model: Other
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        The targeted subjects will be either breast cancer survivors, living in the community,
        without requiring transfers, or healthy, age-matched volunteers.
      
Keywords: chemotherapy; cognitive impairments; breast cancer