Comparison of The Effects of Initial Oral Feeding by Cup and Bottle-Feeding of Preterm Infants
Condition: Oxygen Saturation; Heart Rate; Nutritional Status
MeSH terms: Premature Birth
Study type: Interventional

Summary: 
      The research was planned in a randomized controlled experimental design to determine the
      effects of the cup and bottle used during the first oral feeding on physiological
      characteristics and feeding performance in preterm infants. The research was carried out
      between January 2021 and February 2022 at the Neonatal Intensive Care Unit of Göztepe
      Süleyman Yalçın City Hospital. Research data were obtained from preterm infants who were born
      before 34 weeks of gestation, appropriate to selection of study group criterias and
      hospitalized in the neonatal intensive care unit. A total of 80 babies in the sample group
      were randomly assigned to the experimental (bottle) and control (cup) groups. Oxygen
      saturation, heart rate, feeding performance and test weight before, during and after feeding
      of preterms in both groups were compared. There was no statistically significantly difference
      between the experimental and control groups in terms of oxygen saturation and heart rate.
    

Detailed description: 
      The coordination of sucking, swallowing and breathing is necessary for the preterm infant to
      be effectively and safely fed by the oral route. Although the sucking motion begins in the
      27-28th week, the coordination of sucking, swallowing, and breathing appears in the 32-34th
      week. Introducing oral feeding to preterm infants is recommended by sucking the mother's
      breast when they are ready for oral feeding. Preterm infants are fed through complementary
      feeding methods such as a bottle, spoon, dropper, cup, and finger feeding until they reach
      the condition to meet their nutritional needs by sucking the mother's breast.

      Bottle feeding is one of the nutritive sucking methods commonly used in both preterm and term
      infants worldwide. When the mother is unable to breastfeed or breast milk is not available,
      preterm infants can be fed with a bottle. Bottle feeding contributes to effective feeding and
      helps the infant to relax by meeting the sucking reflex. Cup feeding has been used in
      developed and developing countries for many years to feed premature infants and those with
      low birth weights. Cup feeding is a simple, practical, effective, and low cost method that
      can be used in infants who can swallow but are unable to suck well enough to be fed
      completely from the mother's breast, and in cases where an alternative such as a gastric
      catheter or a bottle is required for feeding.

      Studies that compared bottle and cup feeding reported that the swallowing performance of
      preterm infants fed with a bottle was better, the length of hospital stay was longer in
      preterm infants fed with a cup, and the duration of feeding was longer in preterms fed with a
      cup compared to those fed with a bottle, the rate of breastfeeding after discharge was higher
      in those fed with a cup, no significant difference was found in weight gain, but the quantity
      of food intake was less and the rate of food spillage was higher in preterm infants fed with
      a cup compared to those fed with a bottle. For all of these reasons, bottle feeding is
      reported to be a safer and more appropriate method.

      This randomised controlled experimental study was carried out to compare the effect of cup
      and bottle feeding on physiological characteristics and feeding performance in preterm
      infants born at or below the 34th gestational week. A power analysis was used to determine.
      The study included a total of 80 preterms, 40 preterms for each group. The parents of preterm
      infants who met the inclusion criteria granted their written and verbal consent.

      Experimental Group

      The preterm infant was put on pulse oximetry and monitored, and heart rate and oxygen
      saturation began to be monitored. No invasive intervention or care was provided for the
      infant to rest for 1 hour before feeding. Data were collected during working hours
      (08.00-16.00) to establish common physical environment conditions for each infant. Bottles
      and teats to be used during feeding were sterilised with a steam steriliser. The heart rate
      and oxygen saturation of the infants were recorded 30 minutes before the time of feeding, and
      their signs of preparedness for oral feeding were monitored. After the data were recorded for
      30 minutes, the infant was taken out of the incubator and his/her body weight was measured
      naked with only a clean diaper to determine the test weight. All findings were recorded on
      the "Feeding Monitoring Form".

      After all steps before feeding were completed and recorded, the infant was loosely wrapped
      with a soft cloth and started to be fed by being held only by the researcher in order to
      prevent the effect of different feeding practices of the nurses on the study. As soon as
      feeding was initiated, a stopwatch was activated by another nurse who worked in the clinic in
      order to avoid any bias, and the feeding time was maintained not to exceed 30 minutes to
      prevent the infant from getting tired. During the feeding period, heart rate and oxygen
      saturation were continuously recorded. The infants in the experimental group were fed with a
      bottle. The teat of the feeding bottle was selected to be smaller in size, softer and with a
      smaller hole than the teat of the term infant and suitable for preterm infants. The same
      brand and model of bottle and its teat were used for each infant. All infants in this group
      were fed in a semi-elevated side-lying position, as it was more similar to the position in
      which the infant suckled the mother's breast. The infant's lips were tapped with the bottle
      teat for stimulating to feed, and when the infant opened his/her mouth and drooped his/her
      tongue, the teat of the bottle was put into his/her mouth. During feeding, stimulant
      behaviours such as pushing the bottle back and forth and swirling the bottle in the mouth
      were avoided in order to allow the infant to suck faster and accelerate the flow. The time
      elapsed from when the infant started to suck the bottle until he/she released the bottle from
      his/her mouth was considered as the feeding phase.

      Physiological and behavioural signs of stress (throwing the head backwards, trying to push
      the bottle and cup away with the tongue, arching back, grimacing, fanning the fingers, rapid
      and loud breathing, aspiration, coughing and trying to swallow quickly, desaturation (<90),
      apnoea, tachycardia, bradycardia and colour change) were observed in all bottle and cup-fed
      infants during feeding. Also, signs of fatigue (i.e., decreased muscle tone, inability to
      maintain flexion posture, reduced sucking-swallowing activity, spilling milk out of the
      mouth) were observed in both groups.

      In case of signs of stress and fatigue, feeding was interrupted for a short time and the
      infant was allowed to rest. When the infant was physiologically (HR of 120-160/min, SpO2 ≥90)
      and behaviourally ready, feeding was resumed and the infant was prevented from getting tired
      during feeding and actively participated in feeding. Feeding time was limited to 30 minutes,
      including the infants' resting times. When the infant was no longer sucking, another nurse
      who worked in the clinic stopped the stopwatch in order to prevent bias and the feeding phase
      was terminated. The feeding process was completed at the end of 30 minutes even if the infant
      did not take all of the food.

      After feeding, the body weight of the infants was measured only with the diaper on and the
      test weight was determined. Test weighing is a technique used to measure the amount of
      nutrition of the infant, in which the infant is weighed before and after feeding without
      undressing if the infant is dressed and without changing the diaper if the infant is
      diapered, and 1 gram corresponds to 1 ml of breast milk. After the procedure, the infant was
      put in the incubator in a right-side position to facilitate gastric discharge. The infant was
      followed up for 30 minutes after the end of the feeding. During this time, the pulse oximetry
      continued to record and no intervention was made in order to avoid any effect on
      physiological values. The recorded data were classified into pre-feeding, feeding and
      post-feeding periods, entered into a computer environment, and averaged. The amount of food
      taken by the infant during the 30-minute feeding was recorded, and if the infant was unable
      to take the entire amount of food prescribed by the physician, he/she took the remaining
      amount with an orogastric catheter after the post-feeding measurements were finished.

      Control Group

      The preterm infant was put on pulse oximetry and monitored, and heart rate and oxygen
      saturation began to be monitored. No invasive intervention or care was provided for the
      infant to rest for 1 hour before feeding. Data were collected during working hours
      (08.00-16.00) to establish common physical environment conditions for each infant. The cup to
      be used during feeding was sterilised with a steam steriliser. The heart rate and oxygen
      saturation of the infants in both groups were recorded 30 minutes before the time of feeding
      and their signs of preparedness for oral feeding were monitored. After the data were recorded
      for 30 minutes, the infant was taken out of the incubator and his/her body weight was
      measured naked with only a clean diaper to determine the test weight. All findings were
      recorded on the "Feeding Monitoring Form".

      After all steps before feeding were completed and recorded, the infant was loosely swaddled
      with a soft cloth and started to be fed by being held only by the researcher in order to
      prevent the effect of different feeding practices of the nurses on the study. As soon as
      feeding was initiated, a stopwatch was activated by another nurse who worked in the clinic in
      order to avoid any bias, and the feeding time was maintained not to exceed 30 minutes in
      order to prevent the infant from getting tired. During the feeding period, heart rate and
      oxygen saturation were continuously recorded. The infants in the control group were fed with
      a cup. The cups currently used in the clinic for feeding were selected in a size suitable for
      the preterm infant so that they would not damage the lips, palate and tongue. During feeding,
      all infants in this group were placed in semi-elevated supine position. The cup was inserted
      into the infant's lips and elevated until the milk reached the infant's mouth. The position
      of the infant was adjusted so that when the milk reached the tongue, the infant would start
      foraging, dip his/her tongue into the milk by dimpling and slurp the milk with his/her tongue
      through a negative pressure, swallow as much as he/she wants and leave the rest back to the
      cup. The cup was not raised to allow the infant to slurp the milk more quickly and the milk
      was not poured into his/her mouth, so that the infant was given complete control over the
      feeding. The stopwatch was activated when the infant began to drink the milk from the cup,
      and the stopwatch was stopped when the infant no longer slurped the milk, and the feeding
      process was completed. In case of signs of stress and fatigue, feeding was interrupted for a
      short time and the infant was allowed to rest. When the infant was physiologically (HR of
      120-160/min, SpO2 ≥90) and behaviourally ready, feeding was resumed and the infant was
      prevented from getting tired during feeding and actively participated in feeding. Feeding
      time was limited to 30 minutes, including the infants' resting times. When the infant was no
      longer sucking, another nurse who worked in the clinic stopped the stopwatch in order to
      prevent bias and the feeding phase was terminated. The feeding process was completed at the
      end of 30 minutes even if the infant did not take all of the food. After feeding, the body
      weight of the infants was measured with only the diaper on and the test weight was
      determined. After the procedure, the infant was put in the incubator in a right-side position
      to facilitate gastric discharge. The infant was followed up for 30 minutes after the end of
      feeding. During this time, the pulse oximetry continued to record and no intervention was
      made in order to avoid any effect on physiological values. The recorded data were classified
      into pre-feeding, feeding, and post-feeding periods, entered into a computer environment, and
      averaged. The amount of food taken by the infant during the 30-minute feeding period was
      recorded, and if the infant was unable to take in the entire amount of food prescribed by the
      physician, he/she took the remaining amount with an orogastric catheter after the
      post-feeding measurements were finished.
    

Intervention name(s): Cup feeding; Bottle feeding
Intervention type(s): Behavioral; Behavioral
Intervention description(s): The preterm infant was put on pulse oximetry and monitored, and heart rate and oxygen saturation began to be monitored. The infants' heart rate and oxygen saturation were recorded 30 minutes before feeding, and their signs of preparedness for oral feeding were monitored. After the data were recorded for 30 minutes, the infant was taken out of the incubator and his/her body weight was measured naked with only a clean diaper to determine the test weight. Feeding time was limited to 30 minutes, including the infants' resting time. When the infant was no longer sucking, the stopwatch was stopped, and the feeding phase was terminated. The feeding process was completed at the end of 30 minutes even if the infant did not take all of the food. The infant was followed up for 30 minutes after the end of feeding. During this time, the pulse oximetry continued to record and no intervention was made in order to avoid any effect on physiological values.; The preterm infant was put on pulse oximetry and monitored, and heart rate and oxygen saturation began to be monitored. The infants' heart rate and oxygen saturation were recorded 30 minutes before feeding, and their signs of preparedness for oral feeding were monitored. After the data were recorded for 30 minutes, the infant was taken out of the incubator and his/her body weight was measured naked with only a clean diaper to determine the test weight. During the feeding period, heart rate and oxygen saturation were continuously recorded. Feeding time was limited to 30 minutes, including the infants' resting time. When the infant was no longer sucking, the stopwatch was stopped, and the feeding phase was terminated. The infant was followed up for 30 minutes after the end of the feeding. During this time, the pulse oximetry continued to record and no intervention was made in order to avoid any effect on physiological values.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: preterm infants; oxygen saturation; heart rate