bioihbjkbjnl/mcl2 huggingface dataset:
The Influence of a Stabilization Splint on the Body Posture
Condition: Temporomandibular Disorders; Craniomandibular Disorders; Arthromyalgia; Chronic Disease; Occlusal Appliance
MeSH terms: Temporomandibular Joint Disorders; Temporomandibular Joint Dysfunction Syndrome; Craniomandibular Disorders; Chronic Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      The study was designed to investigate a possible influence of an occlusal stabilization
      splint on the body posture in TMD cases and controls. Interocclusal appliances or occlusal
      splints are therapeutic devices that are most frequently used in the treatment of TMD.
      Changes of the mandibular position and occlusal equilibrations are assumed to have an impact
      on the general body posture.
    

Detailed description: 
      Thirty TMD cases and 10 controls were included in the study. All participants were recruited
      from the School of Dentistry, University of Greifswald. All subjects gave their written
      consent to participate in the study. They then completed a TMD history questionnaire and
      underwent a clinical examination. The examination included palpation of the masticatory
      muscles and the TMJs, range of mandibular motion measurements, and assessment of joint
      noises. The TMD cases were required to have a diagnoses of myofascial pain and/or arthralgia.
      Controls had to be free of pain symptoms in their masticatory muscles and TMJs. Body posture
      was measured during five minutes of walking using an ultrasound-distance measuring device
      (sonoSens® Monitor) with small sensors placed on the skin that continually record changes in
      the distance between them. A static posture evaluation was performed with a contactless, and
      radiation-free static measurement of the back surface and spine using a 3D measurement system
      (formetric II). A second measurement was performed after insertion of the occlusal appliance
      and a third one after 7 days of treatment.

      The occlusal appliances were inserted after the first examination and all participants were
      instructed to use it at night and during examinations.
    

Intervention name(s): occlusal appliance
Intervention type(s): Device
Intervention MeSH terms: Salicylic Acid
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single
Primary purpose: Treatment
Keywords: temporomandibular disorder; craniomandibular disorder; occlusal appliance; clinical trial
COVID-19 and Obstetric Transmission
Condition: COVID; Pregnancy Complications
MeSH terms: Pregnancy Complications
Study type: Observational [Patient Registry]

Summary: 
      The aim of this study is to capture data, laboratory markers, and clinical outcomes of
      obstetric and neonatal outcomes in cases of COVID-19 during pregnancy and of pregnancies
      exposed to a COVID-19 vaccine in Cuyahoga County.
    

Detailed description: 
      A review of the 55 cases of obstetric COVID-19 cases world-wide demonstrate the following
      fetal complications of COVID-19: miscarriage (2%), intrauterine growth restriction (IUGR;
      10%), pre-eclampsia, and pre-term birth (39%). In Wuhan, China, nine women who were COVID-19
      positive were surveilled for vertical transmission and overall obstetric and early neonatal
      outcomes. Amniotic fluid, umbilical cord blood, and neonatal throat swabs were collected at
      the time of delivery, and breastmilk samples were collected after lactation commenced. There
      was no viral detection of COVID-19 demonstrated.2 However, two neonates in the United Kingdom
      have tested positively for COVID-19 after delivery from an infected mother. Most recently,
      antibodies were detected (IgM and IgG) in the serum of a neonate born via cesarean delivery
      to a known positive mother. Therefore, vertical transmission has not been completely ruled
      out.

      Additionally, infection at varying times of pregnancy has not been well delineated or
      correlated to neonatal or maternal outcomes at time of delivery. Therefore, there is a need
      to continue surveying and documenting clinical findings in obstetric COVID-19 cases.

      This study will follow pregnant women who are diagnosed during any point of their pregnancy
      with COVID-19 and those who were vaccinated. during pregnancy. The aim will be to evaluate
      maternal and neonatal specimens for the presence of COVID-19 virus, immune and cellular
      response.
    

Intervention name(s): RT-PCR and antibody testing
Intervention type(s): Diagnostic Test
Intervention description(s): Testing of amniotic fluid, cord blood, amnion and chorion, umbilical cord, vaginal mucous, maternal and neonatal sera, neonatal throat swab, and breast milk.
Intervention MeSH terms: Antibodies
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Pregnant women who have been diagnosed with COVID-19 at any point of their pregnancy.
      
Biospecimen description: 
      Maternal blood, neonatal blood, amniotic fluid, amnion, chorion, umbilical cord, vaginal
      secretion, cord blood, newborn throat swab, breastmilk
Effect of Curodont Repair or Placebo on the Remineralisation in Patients With Class 5 Carious Lesions
Condition: Dental Caries
MeSH terms: Dental Caries
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the therapeutic benefit of Curodont Repair for the
      treatment of early buccal carious lesions compared to placebo.
    

Detailed description: 
      All study participants must have two early class V carious lesions in need of a treatment but
      not of an invasive treatment (split-mouth design). One lesion will be treated with Curodont
      Repair and one with placebo as control (single application). 3 months later fluoride
      (Duraphat) will be applied on both lesions. Study duration is 9 months. For assessment visual
      and tactile evaluation, pictures, ECM, Diagnodent Pen, Canary System, VAS is used.
    

Intervention name(s): Curodont Repair; Placebo; Fluoride
Intervention type(s): Device; Other; Device
Intervention description(s): Self-assembling peptide, biomimetic re-mineralisation; Formulation of Curodont Repair without the peptide P11-4; Single application on day D90
Other intervention name(s): P11-4
Intervention MeSH terms: Fluorides
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Dental caries; Curodont Repair; P11-4
Effect of Core Stability Exercises on Hand Functions in Children With Hemiparesis
Condition: Cerebral Palsy
MeSH terms: Cerebral Palsy; Paresis
Study type: Interventional

Summary: 
      Background: Impaired upper extremity is the major disability facing the children with
      hemiplegia as the inability to use hands for reach; grasp and manipulation affect their daily
      life activities. little attention has been given to gain perspective about abnormal movements
      that are detectable in hemiplegic cerebral palsy that are related to one's level of core
      stability and how they affect their hand functions.
    

Detailed description: 
      Background: Impaired upper extremity is the major disability facing the children with
      hemiplegia as the inability to use hands for reach; grasp and manipulation affect their daily
      life activities. little attention has been given to gain perspective about abnormal movements
      that are detectable in hemiplegic cerebral palsy that are related to one's level of core
      stability and how they affect their hand functions.

      Objective: The purpose was to investigate the effectivness of core stability exercises on
      hand functions in hemiplegic cerebral palsy.

      Methods: Thirty hemiparetic cerebral palsied children of both sexes, ranged in age from 6 to
      8 years enrolled in this study. They randomly assigned into two groups of equal number. Group
      (A) received the selective physiotherapy exercises and group (B) received the same selective
      physiotherapy exercises program in addition to core stability exercises three times/week for
      60 min for 12 weeks. Time motor performance, gross manual dexterity and skills of the upper
      extremity were assessed by using Jebsen Taylor Test (JTHFT), Box and Block Test (BBT) and
      Quality Upper Extremity Skill Test (QUEST) respectively before and after treatment.
    

Intervention name(s): CORE STABILITY EXERCISES
Intervention type(s): Other
Intervention description(s): SELECTED CORE EXERCISES
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Natalizumab Treatment of Progressive Multiple Sclerosis
Condition: Primary Progressive Multiple Sclerosis; Secondary Progressive Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Sclerosis
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to study safety and efficacy of natalizumab treatment of primary
      and secondary progressive multiple sclerosis.

      This will be done by measuring the effect of treatment on inflammation in the CNS by means of
      osteopontin levels in the cerebrospinal fluid (CSF). Safety measures further includes
      physical and neurological examination,blood samples and MRI measures of disease activity.
    

Detailed description: 
      The study will include 12 secondary progressive multiple sclerosis patients and 12 primary
      progressive multiple sclerosis patients to treatment with IV natalizumab for 60 weeks. At
      baseline and week 60 a lumbar puncture will be performed. MRI scans will be performed at
      baseline week 12 and week 60.Safety blood samples will be collected every 12 week.
    

Intervention name(s): Natalizumab
Intervention type(s): Drug
Intervention description(s): 300 mg Natalizumab IV for every 4 week for 56 weeks (15 doses for every patient)
Other intervention name(s): Tysabri
Intervention MeSH terms: Natalizumab
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Primary Progressive Multiple Sclerosis; Secondary Progressive Multiple Sclerosis; Natalizumab; Treatment; Safety; Efficacy; Cerebrospinal fluid; Osteopontin
Health Consequences of Wintering in the French Southern and Antarctic Territories
Condition: Environmental Exposure; Winter Depression; Endocrine System Diseases; Sleep Disorder; Immunologic Activity Alteration
MeSH terms: Sleep Wake Disorders; Endocrine System Diseases; Seasonal Affective Disorder
Study type: Interventional

Summary: 
      Polar stays expose people to extreme climate, isolation and confinement. The combination of
      these factors induces psychological disorders, sleep disorders, immune and endocrine
      disturbances, and deficiencies. In the TAAF, (French Southern and Antarctic Lands) two types
      of population coexist: winter residents, exposed to these stressors over long periods, and
      country people, who benefit from milder conditions and only make short stays. In this
      context, the investigators have decided to set up this cohort study with the objective of
      comparing the state of health of the winterers of the TAAF from 2012 to 2017 with that of the
      country people of the same period, before their stay, during and the year following their
      return.
    

Detailed description: 
      Participants will answer to a questionnaire. This questionnaire will determinate participants
      health about following areas : psychological disorders, sleep disorders, immune and endocrine
      disturbances, and any deficiencies.
    

Intervention name(s): Questionary
Intervention type(s): Other
Intervention description(s): Questions about patient health after wintering in Southern and Antarctic French Lands about social and demographics items, psychologic and psychiatric items, sleep disorders, immunological disorders,and endocrinologic disorders, sociological consequences of wintering
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Intervention model description: Questionnaire
Masking: None (Open Label)
Primary purpose: Prevention
A Motivational Enhancement Approach to Skin Cancer Prevention
Condition: Ultraviolet Rays; Motivation
MeSH terms: Skin Neoplasms
Study type: Interventional

Summary: 
      The specific aims of this research are:

      Aim 1 - To describe the UV protection behaviors and beliefs of young adult patients in a
      dermatology clinic.

      Aim 2 - To examine whether or not the UV protection behaviors and beliefs of young adult
      dermatology patients are associated with age, gender, level of education, marital status,
      contact with skin cancer, time outdoors, skin type, the reason for their visit, and the date
      of data collection.

      Aim 3 - To test the efficacy of a motivational enhancement approach to UV protection
      counseling for young adult dermatology patients, as manifested by favorable changes in UV
      protection stages of change, UV protection self-efficacy, and UV protection attitudes.
    

Detailed description: 
      Although skin cancer is the most common form of cancer in the United States, it is highly
      preventable by reducing exposure to ultraviolet (UV) radiation. However, recent primary
      prevention efforts have been inadequate in evoking behavior change, as manifested by
      increasing rates of ultraviolet radiation exposure, particularly among young adults. These
      findings indicate the need to research novel approaches to skin cancer prevention.

      Motivational enhancement techniques facilitate patient-centered, directive discussions
      wherein practitioners provide clear structure and encourage patients to play an active role
      in the consultation. The use of motivational enhancement techniques for health behavior
      change in medical settings has thus far yielded encouraging results for other health behavior
      change topics, but research has not yet investigated the application of these techniques to
      skin cancer prevention discussions.
    

Intervention name(s): Brief Motivational Enhancement Intervention
Intervention type(s): Behavioral
Intervention description(s): The motivational enhancement intervention lasted 5-8 minutes and consisted of gaining the client's permission to address the topic of skin cancer prevention, exchanging information through the elicit-provide-elicit strategy of information exchange, and summarization/ conclusion based on verbal and nonverbal cues from the participant.
Other intervention name(s): Adaptation of Motivational Interviewing
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Ultraviolet Rays; Motivation; Health Education; Randomized Controlled Trial; Health Knowledge, Attitudes, Practice
Study of Maggot Therapy in Diabetic Foot Ulcers
Condition: DIABETIC FOOT ULCERS
MeSH terms: Diabetic Foot; Foot Ulcer; Ulcer
Study type: Interventional

Summary: 
      This study was a Kind of clinical trial with equal randomization, that have been done from
      January 2009 to June 2011 in the AFZALIPOOR hospital endocrine ward in Kerman-Iran on 128
      diabetic patient who had foot wounds.Replacement of conventional therapy by new methodes is
      one of the more important aims for health professional specially for nurses.One of this new
      treatment is maggot therapy.
    


Intervention name(s): procedure:maggot therapy; conventional therapy
Intervention type(s): Other; Other
Intervention description(s): each times in maggot therapy continued for three days.wound assessment was done before and after any intervention; patients receive ordinary treatment for diabetic foot
Other intervention name(s): larval therapy; mechanical debridement
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: MAGGOT THERAPY; DIABETIC FOOT; NURSING CARE; DRESSING
Exercise and Nutrition Program in Improving Physical Activity and Dietary Behavior in Non-Active, Overweight, or Obese Latinas
Condition: Obesity; Overweight
MeSH terms: Overweight
Study type: Interventional

Summary: 
      This pilot clinical trial studies how well an evidence-based exercise and nutrition program
      adapted for Latinas works in improving physical activity and dietary behavior in non-active,
      overweight, or obese rural Latinas. An exercise and nutrition program may reduce the risk for
      developing certain cancers, obesity, and chronic health conditions in Latinas who are
      non-active, overweight, or obese.
    

Detailed description: 
      PRIMARY OBJECTIVES:

      I. Adapt an effective evidence-based exercise and nutrition program to meet the needs of
      rural Latinas.

      II. Implement the adapted program in a rural Latina population. III. Evaluate feasibility and
      potential to improve physical activity and dietary behavior of the adapted program in a rural
      Latina population.

      OUTLINE:

      Phase I: Create a community advisory board to adapt Strong Women Healthy Hearts Program
      (SWHHP) using feedback on the existing SWHHP from Latinas residing in the community.

      Phase II: Conduct a small pilot study to assess effectiveness of the adapted program (one
      group pre-post design, with data collected at three time points).

      INTERVENTION GROUP: Participants undergo instructor-led exercise and nutrition education
      classes for 60 minutes each twice a week for 12 weeks.
    

Intervention name(s): Exercise Intervention; Nutritional Intervention
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Undergo instructor-led exercise program; Undergo instructor-led nutritional education program
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
What is the Impact of Probiotics on Weight Loss Maintenance in Individuals With Obesity?
Condition: Obesity
MeSH terms: Obesity; Weight Loss
Study type: Interventional

Summary: 
      Weight loss maintenance is the biggest challenge in obesity management, with the majority of
      weight-reduced individuals experiencing weight regain. The intake of probiotics has been
      shown to help in weight loss, but its potential in maximizing weight loss maintenance remains
      unknown. Therefore, the main aim of this study is to investigate the impact of probiotic
      consumption on weight loss maintenance. Secondary aims are to investigate if the intake of
      probiotics influences gut microbiota, cardio-metabolic profile, appetite and inflammatory
      markers.
    


Intervention name(s): probiotics; placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): NYCOPRO, a multistrain probiotic (7 strains of Lactobacilli and Bifidobacteria) sold in the Norwegian pharmacies. 2 capsules/day (one with lunch and one with dinner). 2 text messages daily as a reminder. Follow up meeting at ObeCe (St. Olavs hospital) every month with a research nurse, for weighing, blood pressure measurement and collection of probiotics dose for the following month.; Placebo 2 capsules/day (one with lunch and one with dinner). 2 text messages daily as a reminder. Follow up meeting at ObeCe (St. Olavs hospital) every month with a research nurse, for weighing, blood pressure measurement and collection of probiotics dose for the following month.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Probiotics; Appetite Regulation; Gastrointestinal microbiome; Caloric Restriction; Body weight maintenance; Body composition
Influence of Fampridine on Working Memory in Healthy Young Subjects
Condition: Working Memory
Study type: Interventional
Phase: Phase 2

Summary: 
      Proof of concept study on the acute effects on working memory of 10 mg fampridine SR as well
      as the effects after repeated administration of 10 mg twice daily (3.5 days).

      The hypothesis ist that fampridine improves working memory performance.
    


Intervention name(s): Fampridine SR; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Fampridine SR is an inhibitor of voltage gated potassium channels and is approved in Switzerland for treatment of gait problems in patients with Multiple Sclerosis (MS).; no active component
Intervention MeSH terms: 4-Aminopyridine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Study of PSMA-targeted 18F-DCFPyL PET/CT in the Evaluation of Patients With Renal Cell Carcinoma
Condition: Renal Cell Carcinoma; Kidney Cancer
MeSH terms: Carcinoma; Carcinoma, Renal Cell; Kidney Neoplasms
Study type: Interventional

Summary: 
      In this study the investigators aim to evaluate diagnostic utility of prostate-specific
      membrane antigen (PSMA)-targeted 18F-DCFPyL PET/CT in patients with renal cell carcinoma
      (RCC).
    


Intervention name(s): 18F-DCFPyL; PET/CT
Intervention type(s): Drug; Procedure
Intervention description(s): Positron Emission Tomography - Computed Tomography (PET/CT)
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Effects of Physical Activity on Disease Risk Factors
Condition: Childhood Obesity
MeSH terms: Pediatric Obesity
Study type: Interventional

Summary: 
      Obesity is associated with increased risk of heart disease and diabetes (Kim et al., 2010).
      Appalachian children in Athens County, Ohio, experience higher rates of obesity compared to
      the national average (20.9% vs. 15.4%), which increases their risk of obesity-related
      diseases (Montgomery-Reagan, Bianco, Heh, Rettos, & Huston, 2009). Although physical activity
      (PA) is known to improve fitness and adiposity (Gutin & Owens, 2011; Yin et al., 2009), very
      little is known about the effects of PA on the progression of chronic disease risk factors
      (biomarkers) for obesity-related diseases in children, such as inflammatory markers, lipids,
      and glucose/insulin. This lack of knowledge is due to a limited understanding of the number
      of calories burned during children's free-play PA. This study will assess the impact of a PA
      program (ACT) of known energy cost on obesity-related disease markers in 2nd-4th grade
      children compared to a sedentary control group (SED). The study will recruit children from an
      after-school program in Athens County elementary schools. Baseline and posttest data will
      include measures of height, weight, body composition, blood pressure, and physical activity
      levels. Following baseline measures, children will be randomized into either the ACT or SED
      group for 8 weeks. The ACT group will play recess-type games previously determined to expend
      ≥100 calories in 30 minutes. The SED group children will play sedentary-type activities
      during the same time period. It is hypothesized that the ACT group children will demonstrate
      significant improvements in PA after 8 weeks compared to the SED group children and that
      these improvements will be related to positive changes in body weight and body composition.
    


Intervention name(s): AKIDS II
Intervention type(s): Behavioral
Intervention description(s): Physically active intervention
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention