bioihbjkbjnl/mcl2 huggingface dataset:
Functional Trunk Training in Ataxia Patients
Condition: Ataxia, Spinocerebellar; Ataxias, Hereditary
MeSH terms: Ataxia; Cerebellar Ataxia; Spinocerebellar Ataxias; Spinocerebellar Degenerations
Study type: Interventional

Summary: 
      The study is to examine the effect of functional trunk training on trunk control and upper
      extremity functions in patients with autosomal recessive ataxia.
    

Detailed description: 
      Hereditary ataxias are a group of genetic diseases characterized by slow progressive gait
      disturbance. In addition, coordination disorders can be seen in extremities, speech and eye
      movements. Atrophy is common in the cerebellum. Friedreich's ataxia, ataxia telangiectasia,
      ataxia with vitamin E deficiency, infantile-onset spinocerebellar atrophy and
      Marinesco-Sjögren syndrome are autosomal recessive hereditary ataxias. The constant main sign
      of autosomal recessive ataxia is progressive ataxia.

      The trunk has an important role on dynamic stabilization for postural reactions and limb
      movements. A good trunk support enables movements in other parts of the body to occur more
      regularly. Trunk stabilization is important to support upper and lower extremity movements,
      to meet the loads, and to protect the spinal cord. The relationship between upper extremity
      function, daily living activities and trunk functions has been emphasized in many studies but
      comparative studies about the rehabilitation were very less.

      This study is to evaluate the effect o functional trunk training in patients with autosomal
      recessive ataxia.
    

Intervention name(s): Functional training; Routine training
Intervention type(s): Other; Other
Intervention description(s): The therapy program was planned for 8 weeks and the sessions were performed in 45 minutes (min) for 3 days a week. The functional reach (forward-lateral-cross), trunk rotation exercises were performed in the sitting positions.(25min) Facilitation of trunk extension and elongation in the prone position (10 min). Thoracic mobilization on exercise ball (10min).; The therapy program was planned for 8 weeks and the sessions were performed in 45 minutes (min) for 3 days a week. The strengthening exercises were applied on the mat (3x10 for the first 4 weeks and 3x15 repetition for the last 4 weeks). Eyes open-closed perturbation training was performed for trunk control in sitting and standing positions (10 min.).
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants were divided in two groups. Two groups will get two different intervention.
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: ataxia,rehabilitation,trunk,disabilities
Pilot Trial of Contingency Management for Long-Term Cannabis Abstinence
Condition: Cannabis Use; Adolescent Behavior
MeSH terms: Marijuana Abuse
Study type: Interventional

Summary: 
      This study is a critically important first-of-its-kind investigation of the potential
      research utility of using contingency management to examine long-term changes in cannabis use
      with six months of abstinence. These pilot data will inform a later trial which will focus on
      testing the longitudinal relationships between adolescent cognition and cannabis use,
      questions of high and growing public health significance given adolescents' increased access
      to cannabis with legalization.
    


Intervention name(s): Contingency Management
Intervention type(s): Behavioral
Intervention description(s): Six months of cannabis abstinence will be incentivized using a standard contingency management approach involving an escalating schedule of payment for abstinence and attendance.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Clinical Trial to Evaluate the Effects of Two Novel Hydration Beverage Formulas on Rehydration in Healthy Adults
Condition: Dehydration; Rehydration; Exercise Performance; Exercise Recovery; Fluid Balance; Cognitive Performance
MeSH terms: Dehydration
Study type: Interventional

Summary: 
      Dehydration lowers both physical and mental performance if it is severe enough. Performance
      declines are more pronounced in hot conditions or after prolonged strenuous activity such as
      exercise. Most individuals drink less than their sweat losses during activity, while some
      individuals overdrink and develop a sodium deficiency.

      Water and electrolyte balance must be restored as part of the recovery process after any
      activity that causes sweating. Plain water causes a decrease in plasma sodium concentration
      and osmolality, which reduces the desire to drink and increases urine production. Unless the
      volume ingested exceeds the loss, individuals are in net negative fluid balance throughout
      the recovery period due to urinary losses. When sodium and potassium are added to rehydration
      fluids, urine production is reduced in the hours following rehydration. Rehydration is only
      possible if a volume of fluid equal to or greater than the amount lost through sweat is
      consumed, together with adequate electrolytes.

      The test products for this study, TP1 and TP2, are novel hydration beverage formulas. They
      are an electrolyte drink mixture with five essential vitamins and three times more
      electrolytes than typical sports beverages. The test products create an osmotic force that
      permits water to be supplied to the bloodstream sooner in the digestive system by using a
      specific ratio of sodium, glucose, and potassium. This randomized, placebo-controlled,
      semi-blind, crossover study will evaluate the effects of the test products on rehydration in
      healthy adults.
    


Intervention name(s): TP1; TP2; Placebo
Intervention type(s): Other; Other; Other
Intervention description(s): Participants will receive TP1 during one experimental visit.; Participants will receive TP2 during one experimental visit.; Participants will receive placebo during one experimental visit.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
The Effect of Topiramate on Etonogestrel Concentrations in Contraceptive Implant Users
Condition: Migraine; Migraine;Menstrual; Contraception
MeSH terms: Migraine Disorders
Study type: Interventional
Phase: Phase 1

Summary: 
      A prospective, non-inferiority study to evaluate the pharmacokinetic effect of topiramate on
      serum Etonogestrel (ENG) levels in contraceptive implant users.
    


Intervention name(s): Topiramate
Intervention type(s): Drug
Intervention description(s): Topiramate - Participants will undergo a 6 week titrated regimen of oral topiramate to reach a maximum dose of 400mg per day:
Week 1 - topiramate PO 25mg daily Week 2 - topiramate PO 25mg twice daily Week 3 - topiramate PO 50mg twice daily Week 4 - topiramate PO 100mg twice daily Week 5 - topiramate PO 150mg twice daily Week 6 - topiramate PO 200mg twice daily
Intervention MeSH terms: Topiramate
Intervention model: Single Group Assignment
Intervention model description: Prospective, non-inferiority study to evaluate the pharmacokinetic effect of topiramate on serum ENG levels in contraceptive implant users
Masking: None (Open Label)
Primary purpose: Treatment
Binding of Lu AG06466 in the Brain in Healthy Men
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      A study to learn how Lu AG06466 and one of its break down products binds in the brain after
      single and repeated dosing
    

Detailed description: 
      The study will be conducted in two Parts. Part A: cross over, fed/fasted determined by
      randomized sequence Part B: sequential group

      PET scans will be used to quantify MAGL occupancy
    

Intervention name(s): Lu AG06466
Intervention type(s): Drug
Intervention description(s): capsules, orally
Other intervention name(s): ABX-1431
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Percutaneous Removal and Margin Ablation for Breast Cancer
Condition: Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      We hypothesize that radiofrequency ablation after single-insertion image guided vacuum
      assisted biopsy (IVEB) can be used to achieve negative margins in small unicentric breast
      cancers (≤1.5 cm).
    

Detailed description: 
      Using the Mammotome Breast Biopsy System (IVEB) in conjunction with MRI to predict extent of
      disease, ultrasound to direct removal of the tumor, touch preparation cytology for diagnosis,
      and ablation of margins using radiofrequency ablation (RFA), we propose to develop a
      comprehensive system for same-day diagnosis and treatment of patients with small breast
      lesions.
    

Intervention name(s): Percutaneous Removal and Margin Ablation
Intervention type(s): Procedure
Intervention description(s): Patients with a diagnosis of unicentric invasive breast cancer diagnosed by IVEB will then be assigned to the next available surgery date. On that day, the patient's axillary staging will be done, followed by ablation of the biopsy cavity using RFA. The breast surgery may include lumpectomy (which will be directed with US-guidance to assure more accurate removal of the en bloc IVEB site and the margin zone of ablation) or simple mastectomy with or without reconstruction. The tissue specimen will be sent immediately from the operating room to Pathology for routine processing.
Other intervention name(s): Mammotome Breast Biopsy System (IVEB), Ethicon Endo-Surgery; Radiofrequency Ablation (RFA), RITA Medical Systems; Lumpectomy; Mastectomy
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Image Guided Vacuum Assisted Biopsy; Radiofrequency Ablation; Breast Conservation Therapy; Mastectomy; MRI
The Clinical Profile of Parkinson Disease in Egypt
Condition: Parkinson's Disease
MeSH terms: Parkinson Disease
Study type: Observational

Summary: 
      Multi-center, retrospective observational cohort study in 4 tertiary referral centers in
      Cairo over the period from 2004 to 2016.

      Study population. including all patients with idiopathic Parkinson disease attending.
      Patients were diagnosed in accordance to the United Kingdom - Parkinson Disease Society Brain
      Bank criteria.
    

Detailed description: 
      Retrospective, observational study that involve Medical Record Review (MRR). Data extraction
      and collection from medical records was organized through an electronic structured data
      collection form by two of authors (H.S and N.S).

      The abstraction documents included; patient's age, sex, family history, age at onset, type
      and side of motor symptoms onset, associated non-motor manifestations. Moreover; management
      plan, drug history, outcome and disease progression were also verified and recorded.

      During medical record reviewing (MRR); any missing documentation or poorly recorded
      information was managed by deleting the case.
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Parkinsonian syndromes
IMPAACT 2002: Cognitive Behavioral Therapy and Medication Management for Treatment of Depression in US Youth With HIV
Condition: HIV; Depression
MeSH terms: Depression; Depressive Disorder
Study type: Interventional

Summary: 
      IMPAACT 2002 is a prospective, multi-site, two-arm, cluster-randomized study to evaluate
      whether a health and wellness Cognitive Behavioral Therapy and Medication Management (COMB-R)
      intervention for depression demonstrates improved depression and medical outcomes for
      HIV-infected youth in the United States (US) compared to enhanced standard care (ESC).
    

Detailed description: 
      IMPAACT 2002 was a prospective, multi-site, two-arm, cluster-randomized study that evaluated
      whether a health and wellness Cognitive Behavioral Therapy and Medication Management (COMB-R)
      intervention for depression demonstrated improved depression outcomes (e.g., decreased
      depressive symptoms and greater remission and response rates) and medical outcomes (e.g.,
      increased cluster of differentiation 4 (CD4) T-cell count, decreased HIV RNA level) among
      HIV-infected youth in the US compared to enhanced standard care (ESC). Sites were randomized
      to either the COMB-R intervention or the ESC control arm. Youth enrolled in the study
      attended a Screening/Entry Visit and study visits at Weeks 1, 6, 12, and 24. They had two
      additional follow-up visits at Weeks 36 and 48 for the study team to evaluate if observed
      effects of the intervention were maintained. The intervention was a treatment for depression
      that included a manualized Health and Wellness Cognitive Behavioral Therapy and an
      algorithm-driven Medication Management designed to address the unique challenges faced by
      this population.
    

Intervention name(s): Health and Wellness Combined Cognitive Behavioral Therapy and a Medication Management Algorithm; Enhanced Standard of Care
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Behavioral therapy based on a manualized approach developed specifically for youth living with both HIV and depression, using problem-solving, motivational interviewing and cognitive-behavioral strategies to decrease adherence obstacles and increase wellness. The medication management algorithm includes guidance for clinicians on strategies and tactics to treat depression in this population, including factors to consider when deciding on treatments (i.e., drug-drug interactions, side effects).; Ongoing psychopharmacological and psychosocial counseling and treatment for depression at HIV clinical treatment centers enhanced by providing clinicians with up-to-date information and didactic training on current principles for use of medication and psychotherapy in the treatment of depression.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Cognitive Behavioral Therapy; Medication Management
El Paso Public Health Biorepository
Condition: Oral Disease; Bacterial Disease
MeSH terms: Bacterial Infections; Mouth Diseases
Study type: Observational

Summary: 
      The prevalence of tooth decay and other oral diseases are overlooked indicators of overall
      public health. To improve the understanding of oral health in El Paso, the City of El Paso
      Health Department will work with Texas Tech University Health Sciences Center at El Paso to
      determine factors that contribute to poor oral health, and lead to cavities and
      periodontitis. The team will collect saliva from children and young adults to study oral
      infections, markers of inflammation, and other contributors to oral illnesses in
      Mexican-American individuals.
    

Detailed description: 
      As per summary above.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Male and female patients between the ages of 10-21.
      
Biospecimen description: 
      Saliva and blood samples; bacterial and human DNA will be stored
Food-Effect Pharmacokinetic Study of PL2200
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This trial is a food-effect study to assess fasted versus fed pharmacokinetics of PL2200.
    


Intervention name(s): PL2200 fasted; PL2200 fed
Intervention type(s): Drug; Drug
Intervention description(s): Fasted state; Fed state
Intervention MeSH terms: Aspirin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Keywords: Food-effects PK study in healthy subjects.
Recognition of Second Twin. Second Training vs Naive Performer. PROMPT Mannequin
Condition: Twin Vaginal Delivery Skills
Study type: Interventional

Summary: 
      Anterior foot identification in second twin delivery Two different population of resident in
      ObGyn Group 1 previous formal lecture on twin vaginal delivery followed by PROMPT mannequin
      scenario.

      Group 2 naive residents
    

Detailed description: 
      The present study is addressed to evidential skills in residents with and without previous
      specific didactical approach to twin vaginal delivery in identification of anterior fetal
      foot.

      The two group are randomized by age, sex, seniority. Both the naive and the previous lecture
      groups are invited to scenario without knowing the intention to test their skills.

      The time to reach, the number of attempts are recorded.
    

Intervention name(s): twin vaginal delivery simulation
Intervention type(s): Device
Intervention description(s): skill test after formal lecture and simulation in group 1 and after digital learning only
Other intervention name(s): formal lecture; digital learning
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: two groups randomized One with previous lecture and training, one without
Masking: Single (Participant)
Primary purpose: Treatment
Vascular Reactivity in Metabolic Syndrome and Diabetic Patients Using Diffuse Optical Spectroscopy
Condition: Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Metabolic Syndrome
Study type: Observational

Summary: 
      Metabolic Syndrome is a highly prevalent condition that is comprised of several major
      clustering factors that increase the risk for developing cardiovascular disease. Diffuse
      Optical Spectroscopy is a non-invasively measure can show changes in the microvasculature of
      human. Diffuse Optical Spectroscopy measures the optical absorption and scattering properties
      of near-infrared light in tissues such as muscle in order to quantify the absolute
      concentration of oxygenated and deoxygenated hemoglobin, water, and lipids. It provides
      quantitative and functional information on the microvasculature related to tissue perfusion,
      metabolic changes, and indicators of tissue damage.
    

Detailed description: 
      The researchers can use Diffuse Optical Spectroscopy to monitor changes in the
      microvasculature of patients with Metabolic Syndrome and diabetic mellitus, and patients with
      Diabetic Peripheral and Autonomic Neuropathy, versus non-diseased and predisposed subjects by
      evaluating the changes in oxygen metabolism. The Diffuse Optical Spectroscopy measure the
      changes in the concentration and oxygen saturation of hemoglobin in the microvasculature
      under stress, for example, during exercise and in response to changes in breathing habits.
      The sensitivity of Diffuse Optical Spectroscopy to tissue hemodynamics provides an impressive
      arena of useful clinical applications..
    

Intervention name(s): Diffuse Optical Spectroscopy
Intervention type(s): Device
Intervention description(s): Diffuse Optical Spectroscopy non-invasively measure changes in the microvasculature
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        primary care clinic, community sample
      
Keywords: Metabolic Syndrome
Study of Endostar With Cisplatin and Capecitabine as 1st Line Treatment in the Advanced Gastric Cancer
Condition: Advanced Gastric Cancer
MeSH terms: Stomach Neoplasms
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to investigate whether endostar (recombinant human
      endostatin)with cisplatin and capecitabine (Xeloda) as 1st line treatment in the advanced
      gastric cancer is effective and safe.
    

Detailed description: 
      Endostar, a recombinant human endostatin, has shown its antitumor ability in combination in
      NSCLC and breast cancer. But to gastric cancer, few clinical data has been reported. However,
      bevacizumab, an angiogenesis inhibitor was shown effective in combination with chemotherapy
      in advanced gastric cancer in some phase II study. So in this study, we want to explore
      whether endostar is also effective and safe in advanced gastric cancer. Response predictive
      factor is expected to be identified.
    

Intervention name(s): endostar, cisplatin, capecitabine; capecitabine; cisplatin
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Product 1: endostar
Dosing schedule: 15mg daily dose, d1-14
Mode of administration: intravenously; Product 2: capecitabine
Dosing schedule: 1000mg/m2 bid, days 1-14, every 3 weeks
Mode of administration: orally; Product 3: cisplatin
Dosing schedule: 80mg/m2, day 1 of every 3 weeks
Mode of administration: intravenously
Intervention MeSH terms: Cisplatin; Capecitabine; Endostar protein
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Comparison of the LMA Unique and LMA Supreme in Children
Condition: Children
Study type: Observational

Summary: 
      The goal of this study is to compare the LMA Unique and LMA Supreme in children having
      surgery. We hypothesize that the airway leak pressures with the LMA Supreme will be superior
      to the LMA Unique. Airway leak pressures will be measured by recording the circuit pressure
      at which equilibrium is reached. The ease of placement, fiberoptic grade of laryngeal view,
      feasibility of use, and complications (airway related, gastric insufflation, trauma) will
      also be assessed.
    

Detailed description: 
      The LMA Supreme is a newer version of the current model, the laryngeal mask airway Unique.
      Both models are approved for use by the FDA, and are routinely used for airway management
      during general anesthesia. Three main features distinguish the laryngeal mask airway Supreme
      from the original LMA: i) a curved rigid airway tube, ii) provision for a gastric drain tube,
      and iii) a larger mask for improved fit and airway seal.

      The aim of this randomized prospective study is to compare two types of the laryngeal mask
      airway: the laryngeal mask airway Unique and the laryngeal mask airway Supreme, in pediatric
      patients without the use of neuromuscular blockade. Based on the design features listed
      above, we hypothesize that the airway leak pressures with the LMA Supreme will be superior to
      the LMA Unique. Airway leak pressures will be measured by recording the circuit pressure at
      which equilibrium is reached. The ease of placement, fiberoptic grade of laryngeal view,
      feasibility of use, and complications (airway related, gastric insufflation, trauma) will
      also be assessed.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Children weighing 10 to 25 kg undergoing surgical or medical procedures under anesthesia
        requiring a supraglottic airway device
      
Keywords: supraglottic airway devices in children