Evaluation of Halitosis After Treatment With Photodynamic Therapy Associated With Periodontal Treatment
Condition: Halitosis
MeSH terms: Halitosis
Study type: Interventional

Summary: 
      The aim of this randomized, controlled clinical trial was to treat oral halitosis in healthy
      adults with photodynamic therapy associated with periodontal treatment and follow them up for
      3 months. The participants with halitosis will be randomized into two groups: G1-treatment
      with photodynamic therapy or G2-cleaning of the tongue with a tongue scraper . Halitosis were
      evaluated measuring volatile sulfur compounds using gas chromatography After the treatments,
      a second evaluation will be performed, along with a microbiological analysis (qPCR) for the
      identification of the bacteria T. denticola
    

Detailed description: 
      Halitosis is an unpleasant odor that emanating from the mouth. A recent metanalysis shows
      worldwide trend towards a rise in halitosis prevalence. Studies show halitosis returns in a
      week after treatment with photodynamic therapy (PDT). Probably, bacteria residing in the
      periodontal sulcus could recolonize the dorsum of the tongue. To date, there are no study in
      adult population that associate halitosis and periodontal treatment with follow-up
      evaluation. The aim of this randomized, controlled clinical trial was to treat oral halitosis
      in healthy adults with photodynamic therapy associated with periodontal treatment and follow
      them up for 3 months. The participants (n=40) with halitosis will be randomized into two
      groups: G1-treatment with photodynamic therapy (n = 20) or G2-cleaning of the tongue with a
      tongue scraper (n = 20). Halitosis were evaluated measuring volatile sulfur compounds using
      gas chromatography After the treatments, a second evaluation will be performed, along with a
      microbiological analysis (qPCR) for the identification of the bacteria T. denticola. The
      evaluation of halitosis and the microbiological analysis will be repeated. After that,
      patients will receive periodontal treatment. The participants will return after 1 week and
      three months for an additional evaluation. Quality of life will be measured by Oral Health
      Impact Profile (OHIP-14) Comparisons will be made with ANOVA test, with the level of
      significance of 5 %. This protocol will determine the effectiveness of phototherapy regarding
      the reduction of halitosis in adults.
    

Intervention name(s): Pdt Photodynamic Therapy; tongue scrapper
Intervention type(s): Device; Other
Intervention description(s): device irradiation with low intensity laser (wave length = 660 nm) 9 J (Joules) per point(6 points) and radiant 90 seconds PS will be applied in sufficient quantity to cover the middle third and back of the tongue and wait for 5 minutes.six points with the distances of 1 cm between them will be irradiated.; Tongue scrapping will be performed by the same operator in all patients. Posterior -anterior movements will be performed with the scrapper over the lingual dorsum. in order to promote the mechanical removal of tongue coating
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Bio-equivalence Study Enrollment:40
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: photodynamic therapy; periodontal disease; randomized controlled clinical study