The Immun Status Changes Due to Intermittent Fasting
Condition: Intermittent Fasting
Study type: Interventional

Summary: 
      Positive effects of calorie restriction on quality of life and diseases are reported.
      Intermittent fasting, one of the calorie restriction methods, has been shown to be beneficial
      for health with many metabolic effects, not just calorie restriction. Preclinical studies
      show the disease-modifying effects of intermittent fasting in animal models on a wide variety
      of chronic disorders, including obesity, diabetes, cardiovascular disease, cancers, and
      neurodegenerative brain diseases. There are very few studies evaluating the effects of
      intermittent fasting on the immune system, and only TNFα, IL6 and IL10 cytokines were
      evaluated in these studies to evaluate the immune system. In this study, we aimed to evaluate
      the conditions of inflammatory markers in peripheral blood before and after intermittent
      fasting period in overweight volunteers with a Body Mass Index between 25 and 30. Volunteers
      will have intermittent fasting for 3 weeks, which conforms to the 16-hour fasting and 8-hour
      meal format.
    

Detailed description: 
      In a 1997 article by Weindruch and Sohal, they reported that reducing food availability
      (calorie restriction) throughout life has significant effects on aging and lifespan in
      animals. There are many modalities for calorie restriction, one of which is intermittent
      fasting. Intermittent fasting involves having little or no energy intake during a certain
      period of the day, then free intake of energy for the rest of the day. Some of the modalities
      applied in this context can be listed as 12 hours fasting-12 hours eating, 16 hours fasting-8
      hours eating, 20 hours fasting-4 hours eating. Studies in animals and humans show that most
      of the health benefits of intermittent fasting are not just the result of decreased free
      radical production or weight loss. Instead, intermittent fasting elicits cellular responses
      that can adapt to improve glucose regulation between and within organs, increase stress
      resistance, and suppress inflammation. During intermittent fasting, cells activate pathways
      that increase their defenses against oxidative and metabolic stress and remove or repair
      damaged molecules.Preclinical studies show the disease-modifying effects of intermittent
      fasting in animal models on a wide variety of chronic disorders, including obesity, diabetes,
      cardiovascular disease, cancers, and neurodegenerative brain diseases . Periodic opening and
      closing of metabolism with intermittent fasting not only provides the ketones necessary for
      cells to use during the fasting period, but also elicits highly regulated systemic and
      cellular responses to increase mental and physical performance and disease resistance.

      There are very few studies evaluating the effects of intermittent fasting on the immune
      system, and only TNFα, IL6 and IL10 cytokines were evaluated in these studies to evaluate the
      immune system. In one of these studies, it was reported that proinflammatory cytokines of
      TNFα, IL6, which were measured after intermittent fasting for 30 days for 14 hours, decreased
      significantly.

      In this study, the investigators aimed to evaluate the effect of 16-hour fasting and 8-hour
      intermittent fasting application on overweight volunteers with a Body Mass Index of 25-30 for
      inflammatory markers in peripheral blood .
    

Intervention name(s): Intermittent fasting
Intervention type(s): Other
Intervention description(s): 30 overweight male volunteers who will have 3 weeks intermittent fasting which has 16 hours fasting and 8 hours eating in a day period.
Intervention model: Single Group Assignment
Intervention model description: Cytokine levels before and after intermittent fasting period for 3 weeks
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Cytokine; Intermittent fasting