bioihbjkbjnl/mcl2 huggingface dataset:
Loss of Control Eating Following Weight Loss Surgery
Condition: Loss of Control Eating
MeSH terms: Weight Loss
Study type: Interventional

Summary: 
      This study will test the effectiveness of two distinct behavioral treatments for loss of
      control eating following bariatric surgery:

        1. Behavioral Weight Loss Treatment

        2. Cognitive Behavioral Therapy

      These treatments will be compared to Standard-of-Care.
    


Intervention name(s): Standard-of-Care; Behavioral Weight Loss Treatment; Cognitive Behavioral Therapy
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Standard-of-Care with bariatric team. Participants will be encouraged to continue their care with their bariatric team.; Biweekly individual guided self-help sessions for 3 months; Biweekly individual guided self-help sessions for 3 months
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Bariatric surgery; Weight loss surgery; Behavioral weight loss treatment; Cognitive behavioral therapy; Behavioral treatment; Obesity; Morbid obesity; Binge eating; Binge eating disorder; Loss of control eating; Overeating
Study to Assess Potential Different Properties of Telmisartan Compared to Candesartan in Healthy Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 4

Summary: 
      Study to assess potential different properties of telmisartan, which due to its Vd, should
      result in stronger "beneficial" effects of AT1 blockade in tissues (e.g. aldosterone
      suppression and renin increase) plus stronger AT2 stimulation compared to candesartan
    


Intervention name(s): Telmisartan; Candesartan; Placebo
Intervention type(s): Drug; Drug; Drug
Other intervention name(s): Micardis®; Blopress
Intervention MeSH terms: Telmisartan; Candesartan; Candesartan cilexetil
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single
Primary purpose: Treatment
Positive End-expiratory Pressure and Alveolar Recruitment for One Lung Ventilation
Condition: One Lung Ventilation
Study type: Interventional

Summary: 
      Hypoxia frequently develops during one lung ventilation in the supine position.The objective
      of this article is to study the impact of preemptive alveolar recruitment and subsequent
      positive end expiratory pressure on arterial oxygenation and lung mechanics during one lung
      ventilation in the supine position in patients undergoing thoracic surgery .
    

Detailed description: 
      outcome measures: respiratory parameters (Paw, Ppla, Compliance, Vd/Vt)and oxygenation
      parameters (PaO2, shunt fraction, Pa-AO2)
    

Intervention name(s): PEEP
Intervention type(s): Other
Intervention description(s): 8 cmH2O PEEP throughout the period of OLV and 2nd TLV
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Prevention
Keywords: positive end expiratory pressure
Investigating Accelerated Learning and Memory in Healthy Subjects Using a Face Name Memory Task
Condition: Healthy Adults
Study type: Interventional

Summary: 
      The purpose of this study is to investigate whether we can accelerate learning and improve
      associative memory performance in healthy subjects by applying transcranial Direct Current
      Stimulation (tDCS) during a Face Name memory task.
    

Detailed description: 
      Associative memory refers to remembering the association between two items, such as a face
      and a name or a word in English and the same word in another language. It is not only
      important for learning, but it is also one of the first aspects of memory performance that is
      impacted by aging and by Alzheimer׳s disease. For decades, neuroscientists have investigated
      associative learning and memory and ways to accelerate and enhance associative learning and
      memory.

      Transcranial Direct Current stimulation (tDCS) is a non-invasive and painless electrical
      stimulation technique that has demonstrated to accelerate learning and improve memory in some
      studies. To investigate whether we can accelerate learning and improve associative memory
      using tDCS, we will compare the performance in a Face Name Associate memory task from 2
      groups. The first group will get active tDCS during the study phase of the Face Name Memory
      task, whereas the second group will get sham tDCS during the study phase of the task.
    

Intervention name(s): tDCS; sham tDCS
Intervention type(s): Device; Device
Intervention description(s): active tDCS; sham tDCS
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants will be randomly assigned to one of two groups: (1) active tDCS with Face Name associate memory task (2) sham tDCS with Face Name associate memory task
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: transcranial Direct Current Stimulation (tDCS); accelerated learning; memory
A Study Evaluating Efficacy, Toxicity, Harvest Yield and Quality of Life
Condition: Multiple Myeloma
MeSH terms: Multiple Myeloma; Neoplasms, Plasma Cell
Study type: Interventional
Phase: Phase 2

Summary: 
      Four monthly treatments with pegylated liposomal doxorubicin, thalidomide and dexamethasone
      for newly diagnosed myeloma patients as induction therapy prior to high dose chemotherapy and
      autologous stem cell transplant.
    

Detailed description: 
      Multiple myeloma (MM) is an incurable hematological malignancy of plasma cell origin. Plasma
      cell clonality and dysfunctional immunoglobulin production characterize the disease. The
      consequences of abnormal plasma cell growth are manifested by a myriad of symptoms and signs
      that often have significant impact on the patient's quality of life. These include
      pancytopenia secondary to predominant distribution of tumor cells within the bone marrow
      along with many other effects.

      This study is focused on the efficacy of Doxil® (pegylated liposomal doxorubicin) with low
      dose Dexamethasone and Thalidomide (Ddt) in previously untreated patients with multiple
      myeloma.
    

Intervention name(s): Doxil; Thalidomide; Dexamethasone
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Doxil 40 mg/m2 IV day 1; 50-100 mg day 1-28; Dexamethasone 40 mg day 1-4 and 15-18
Other intervention name(s): pegylated liposomal doxorubicin; thalidomid; decadron
Intervention MeSH terms: Thalidomide; Dexamethasone; Doxorubicin; Liposomal doxorubicin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Corneal and Conjunctival Sensitivity and Staining Study
Condition: Myopia; Hyperopia
MeSH terms: Hyperopia
Study type: Interventional
Phase: Phase 4

Summary: 
      The primary objective of this study is to compare subjective symptoms and ocular health in a
      group of individuals who are currently wearing soft contact lenses on a daily wear basis,
      after a short period of no lens wear and during the time course when using differing care
      regimens.
    

Detailed description: 
      The primary objective of this study is to compare subjective symptoms and ocular health in a
      group of individuals who are currently wearing soft contact lenses on a daily wear basis,
      after a short period of no lens wear and during the time course when using differing care
      regimens. Observations will be made to monitor physiology.
    

Intervention name(s): Optifree RepleniSH Multipurpose Disinfecting Solution; ReNu Multiplus Multipurpose Solution
Intervention type(s): Drug; Drug
Intervention description(s): lens care system; lens care system
Other intervention name(s): lens care system; lens care system
Intervention MeSH terms: Pharmaceutical Solutions
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
DNI Values After Periodontal Treatment
Condition: Periodontitis; Periodontal Inflammation; Inflammatory Response
MeSH terms: Periodontitis; Inflammation
Study type: Interventional

Summary: 
      The study included 70 systemically healthy individuals, as a test group of 35 patients with
      Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal
      disease. Blood samples were taken for the examination of DNI, white blood cells (WBC),
      immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and
      neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3
      months after NSPT.
    

Detailed description: 
      The role of the Delta Neutrophil Index (DNI) in the pathogenesis and follow-up of periodontal
      disease has not been comprehensively documented. The study included 70 systemically healthy
      individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control
      group of 35 individuals with no periodontal disease. Blood samples were taken for the
      examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin,
      C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with
      periodontitis, blood sample assays were repeated 3 months after NSPT.
    

Intervention name(s): Only routine non-surgical periodontal treatment was applied to the patients.
Intervention type(s): Other
Intervention description(s): The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after non-surgical periodontal treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Prospective Study of Cyclophosphamide in Systemic Lupus Erythematosus Treatment
Condition: Systemic Lupus Erythematosus
MeSH terms: Lupus Erythematosus, Systemic
Study type: Interventional

Summary: 
      The purpose of this study is to compare the genotype-based personal prescription of
      cyclophosphamide with the traditional prescription.
    

Detailed description: 
      Cyclophosphamide (CPA) has been one of the most successful therapies for severe Systemic
      lupus erythematosus (SLE). However, cyclophosphamide can cause severe side effects, including
      bone marrow suppression, infection, gastrointestinal reaction, hemorrhagic cystitis, and the
      etc. Significant variation in efficacy and toxicity of CPA has been observed. Since the
      development of applicable therapeutic drug monitoring (TDM) of cyclophosphamide has been
      reported, it will help to improve the efficacy and reduce toxicities in SLE treatment.
      However, the TDM is a passive strategy which usually lags behind the appearance of
      toxicities. Therefore，it is especially crucial to give individuals genotype-based personal
      prescription of cyclophosphamide in order to gain the most effective therapies. Thus, the
      purpose of this study is to compare the genotype-based personal prescription of
      cyclophosphamide with the traditional prescription, in order to verify the efficacy of the
      genotype-based personal prescription.
    

Intervention name(s): Genotype Detection
Intervention type(s): Genetic
Intervention description(s): To Genotype cases in the experimental group and divide them into three groups, including extensive metaboliser (EM), intermediate metaboliser (IM) and poor metaboliser (PM).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Cyclophosphamide; genotype-based therapy; prospective study
Wheatgrass Juice / Lifestyle Recommendations / Cancer Patients' Quality of Life / Chemotherapy Treatment
Condition: Fatigue
MeSH terms: Fatigue
Study type: Interventional

Summary: 
      This study is aimed to study the impact of wheatgrass juice and lifestyle recommendations
      (diet, physical activity and breathing exercises) on the well being, fatigue and
      hematological parameters of chemotherapy-naive patients with no evidence for symptoms of
      active oncological disease.The researchers hypothesize that both wheatgrass juice and
      lifestyle recommendations can improve patient's well-being during chemotherapy.
    

Detailed description: 
      Chemotherapy-naive patients will be offered to participate in a two arms study. Following
      consent, patients will be randomized to one of two arms. Patients in both arms will be
      provided by booklet and audio-cassette that specify lifestyle recommendations (diet, physical
      activity and breathing exercises). Patients in one of the study arms will be provided in
      addition with frozen wheatgrass juice (recommended daily dosage of 55-110 CC daily). Patients
      in both arms will be asked to fill in a daily patient's diary monitoring the practice of the
      lifestyle recommendations.

      Baseline assessment will include the following questionnaires: ESAS, MYCAW, FACIT- Fatigue.
      Evaluation will include weekly ESAS and FACIT-Fatigue questionnaire and subsequent evaluation
      (including ESAS, MYCAW, FACIT- Fatigue questionnaires) following 3 and 4 chemotherapy cycles
      of treatment. Follow-up evaluation will be performed at the completion of chemotherapy.
    

Intervention name(s): Wheatgrass juice
Intervention type(s): Dietary Supplement
Intervention description(s): 110 CC daily od frozen wheatgrass juice in the intervention arm
Other intervention name(s): Triticum aestivum
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Fatigue; Quality of life; Lifestyle; Complementary medicine
MTF Image Modifications
Condition: Modulation Transfer Function; Visual Acuity; Contrast Sensitivity
MeSH terms: Hypersensitivity
Study type: Observational

Summary: 
      Human visual acuity and contrast sensitivity are highly dependent on various different
      parameters. Each should be optimized for perfect visual performance. However, in real life
      our eyes lack such parameters, which might lead to unsatisfying results even after spectacle
      correction or contact lenses.

      A promising approach would be to design intra ocular lenses (IOL), which are implanted into
      the eye for example in the course of cataract extraction and are able to compensate for the
      human eyes' aberrations.

      For example cutoff frequency, edge-sharpness or specific contrast for selected structure
      sizes would need to be considered. Since, an aberration free optical system is almost
      impossible and since the impact of each single parameter is not yet known, IOL design
      parameters would have to be chosen very carefully.

      Furthermore, image quality of IOLs still is tested ex vivo by ray tracing for example, but
      this does not guarantee perfect function after implantation, as our visual system has complex
      image precessing units form the retina to the brain.

      The present study picks one of these parameters and seeks to assess its impact on visual
      quality in-vivo. By subjectively grading different images with objective changes to image
      quality by variations of the modulation transfer function (MTF), the potential influence and
      thus on our subjective visual impression shall be assessed.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        healthy, male and female subjects 18-35 years non-smokers
Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors
Condition: Brain and Central Nervous System Tumors
MeSH terms: Astrocytoma; Meningioma; Nervous System Neoplasms; Central Nervous System Neoplasms
Study type: Interventional
Phase: Phase 2

Summary: 
      RATIONALE: Biological therapies such as gefitinib may interfere with the growth of tumor
      cells and slow the growth of CNS tumors.

      PURPOSE: Phase II trial to study the effectiveness of gefitinib in treating patients who have
      recurrent or progressive CNS tumors.
    

Detailed description: 
      OBJECTIVES:

        -  Determine the maximum tolerated dose of gefitinib in patients with recurrent or
           progressive supratentorial malignant gliomas or brain or spinal meningiomas receiving
           enzyme-inducing antiepileptic drugs (EIAEDs). (Phase I of the study closed to accrual as
           of 09/19/2003).

        -  Determine the toxic effects of this drug in these patients.

        -  Determine the pharmacokinetics of this drug in patients receiving EIAEDs.

        -  Determine the efficacy of this drug in terms of 6-month progression-free survival of
           these patients.

        -  Determine the safety profile of the phase II dose of this drug in these patients.

      OUTLINE: This is a multicenter, dose-escalation study. Patients are stratified according to
      concurrent enzyme-inducing antiepileptic drugs (EIAEDs) (yes vs no) and disease type (for
      phase II only) (benign meningioma vs malignant meningioma vs hemangiopericytoma vs
      glioblastoma vs other anaplastic glioma). (Phase I closed to accrual as of 09/19/2003).

      Patients receive oral gefitinib once daily on days 1-28. Courses repeat every 28 days in the
      absence of disease progression or unacceptable toxicity.

      Cohorts of 3-6 patients (who are receiving EIAEDs) receive escalating doses of gefitinib
      until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose
      preceding that at which at least 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.

      Patients are followed at 2 weeks.

      PROJECTED ACCRUAL: A minimum of 30 patients will be accrued for the phase I portion of this
      study within 10 months . (Phase I closed to accrual as of 09/19/2003). A total of 48 patients
      will be accrued for the phase II portion of this study within 6-8 months.
    

Intervention name(s): gefitinib
Intervention type(s): Drug
Intervention MeSH terms: Gefitinib
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: recurrent adult brain tumor; adult meningioma; adult glioblastoma; adult anaplastic astrocytoma; adult anaplastic oligodendroglioma; adult pilocytic astrocytoma; adult subependymoma; adult mixed glioma; adult meningeal hemangiopericytoma; adult grade III meningioma; adult giant cell glioblastoma; adult gliosarcoma; adult grade I meningioma; adult grade II meningioma
Validation and Test-retest Study of the Star-shaped Manual Dexterity Test.
Condition: Manual Dexterity
Study type: Interventional

Summary: 
      The purpose of this study is to measure test-retest reliability and validate the star shaped
      test of manual dexterity. The purpose of this is to see if there is any significant learning
      effect, and if the test can discriminate between individuals who are at their normal skill
      level, and when they are stressed and/or fatigued. The test is designed to test hand to eye
      coordination and precision control. This is done by following a star shaped track with a pair
      of a surgical scissors. this is done 10 times, 5 times clockwise and 5 times counter
      clockwise. Each time the scissors come into contact with the border of the track, an error is
      counted. Overall completion time is recorded. As a randomized crossover study, we will have
      20 test subjects complete the test 4 times. Each test will be conducted with a pause of two
      breaks between the tests. Before each test, the test subjects are randomized to: no
      intervention, physical fatigue prior to testing, distractions during the test or both
      physical fatigue prior to testing and distractions during the test. All participants will
      complete a test with all four interventions. Furthermore, a test-retest trial will be
      conducted on 4 test-subjects. Each subject will complete the test two times with no
      interventions, with two days apart.
    


Intervention name(s): Stretched arm test; Stress; Star shaped manual dexterity test
Intervention type(s): Other; Other; Device
Intervention description(s): Measurement of static arm strength. Test subject is asked to hold a 2.5 kg weight in their dominant arm fully extended at 90-degree flexion and 15-degree abduction as long as possible without moving.; During completion of the star shaped manual dexterity test, the test subject is asked to identify cards from a regular deck of playing card by naming the suit and rank of the card. They will be asked to identify one random card during each of the 10 rounds in the completion of the test; On a piece of wood, a piece of metal (dimensions 22 cm x 22 cm) is mounted. In the center of the metal plate, is a star shaped track. The star has 6 points and the track is 9 mm wide. It measures 15,3 cm from the tips of opposing arms of the star. With a surgical scissor in his dominant hand, the test subject is instructed to follow the star shaped track ten times, five times clockwise and five times counter clockwise. Contact with the border of the track is counted as an error. A computer software program automatically registers completion time and number of errors. The test is conducted in an undisturbed environment.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Investigator)
Primary purpose: Basic Science
Keywords: Manual dexterity; hand to eye coordination; stress; fatigue