bioihbjkbjnl/mcl2 huggingface dataset:
Effectiveness of Percutaneous Electrolysis in the Treatment of Lateral Epicondylalgia. A Single-Blind Randomized Controlled Trial.
Condition: Epicondylitis
Study type: Interventional

Summary: 
      The concept of epicondylitis refers to the manifestation of pain ni the area of insertation
      of the epicondile muscles, and that it is accompained by limitation funcional.A tendinopathy
      is characterized as a process of degenaration, with fibroblast proliferation and
      disorganization of the fibers of collagen. This tendon pathology especially affects the
      epicondyle extensors and especially the first and second radial and short extensor carpal.
    

Detailed description: 
      Eccentric exercises of the epicondyle muscles were performed in 3 sets of 10 repetitions.
      Participants were asked to perform the exercise program on an individual basis twice every
      day for 4 weeks. The eccentric program consisted of 3 exercises, focusing on the epicondyle
      muscles. Participants were asked to do a normal flexion extension (concentric phase) and a
      slow return to the initial position (eccentric phase) included first the concentric phase,
      and the eccentric phase was slowly conducted. The exercise program was taught by a
      physiotherapist in the first session and monitored in the subsequent sessions.
    

Intervention name(s): Epte group; Dry needling group
Intervention type(s): Other; Other
Intervention description(s): Therapeutic Percutaneous Electrolysis once week for four weeks associated with eccentric exercises devices at home.; The intervention for this group consisted of dry needling in trigger points associated with eccentric exercises devices at home.
Other intervention name(s): EPTE + EXER; DN +EXER
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A specialist physician will be diagnosed the epicondylitis
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Tendinopathy; Electrolysis; Exercise; Dry needing
Cognitive Flexibility Training in Persistent Pain
Condition: Chronic Pain
MeSH terms: Chronic Pain
Study type: Interventional

Summary: 
      To determine whether participation in a cognitive training program over a training period of
      five weeks improves cognitive flexibility in patients with chronic hip, knee, and back pain.
    

Detailed description: 
      This project is a single-center prospective, randomized study to assess whether cognitive
      flexibility can be improved through training on a Lumosity®-based training module over the
      course a five week timeframe in patients with chronic hip, knee, and back pain; and whether
      changes in cognitive flexibility will correlate with perceived pain scores.
    

Intervention name(s): Training
Intervention type(s): Behavioral
Intervention description(s): The intervention group will be provided with the cognitive training module and participants will be required to complete a targeted 36-minute daily training for 35 days.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Mesenchymal Stromal Cells for Degenerative Meniscus Injury
Condition: Chronic Meniscal Injury
MeSH terms: Wounds and Injuries
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The present proposal has the objective to assess whether the addition of autologous ex vivo
      expanded mesenchymal stromal cells (XCEL-M-ALPHA) to the conventional meniscal injury
      rehabilitation program is contributing in creating the proper healing environment for the
      meniscus repair. For this purpose, 20 patients will be randomized (10 per group) to one of
      the two treatment arms (rehabilitation + xcel-m-alpha or rehabilitation alone) . The
      conduction of this clinical trial will, in addition of having the aim of improving the
      patient's quality of life, contribute to consolidate an emerging new type of therapy which is
      still under development.
    

Detailed description: 
      This is a prospective, unicentric, randomized, open-label, single-dose, two-arm, blinded
      assessor pilot study in which 20 patients with degenerative meniscus injury grade 3 (Crues et
      al.) will enter the study with the primary objective of assessing the efficacy of the
      treatment by VAS of pain at 12 month. Secondary objectives are to evaluate the safety and
      efficacy through imaging procedures and clinical questionnaires (IKDC, KOOS, Lysholm and
      SF-36.

      Patients will be randomized to one of the two treatment arms (XCEL-M-ALPHA and standard
      rehabilitation program or standard rehabilitation program alone). Thereafter, patients will
      be followed for 12 months.

      Imaging assessment will be performed by an independent blinded radiologist.
    

Intervention name(s): XCEL-M-ALPHA and standard rehabilitation; Rehabilitation
Intervention type(s): Drug; Other
Intervention description(s): Intraarticular infusion of autologous bone marrow derived ex vivo expanded mesenchymal stromal cells produced at Xcelia (Advanced Therapies Division of the Blood and Tissue Bank); Standard rehabilitation program
Other intervention name(s): XCEL-M-ALPHA
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Chronic Meniscal Injury; Degenerative meniscus; Meniscus injury; Meniscal injury; Mesenchymal stromal cells; Mesenchymal stem cells; Advanced Therapy; Bone marrow
Study of Herbal Formula Corresponding to Syndrome in Treating Post Percutaneous Coronary Intervention (PCI) Patients With Coronary Heart Disease (CHD)
Condition: Coronary Heart Disease
MeSH terms: Heart Diseases; Coronary Disease; Coronary Artery Disease; Myocardial Ischemia
Study type: Interventional

Summary: 
      We conduct this clinical trial to determine the effects of Xuefu Zhuyu capsule (based on TCM
      "Zheng Hou" theory) in helping recovery from coronary heart disease(CHD)after PCI and find
      out whether this kind of effecacy is much better within patients administered with TCM
      syndrome-based individualized medication.
    

Detailed description: 
      The effectiveness of a Chinese herbal formulae is not completely based on the disease or some
      biomedical indexes, but much more on the TCM syndrome(Chinese name:Zheng Hou)which is
      generalized from patients' TCM signs and symptoms. Thus, conventional medical curative
      effecacy evaluation system seems not to so fit for TCM clinical studies. Although many
      clinical studies from Chinese literature have reported the beneficial effects of various of
      TCM herbal agents in improving symptoms and signs as well as antagonism of specific
      pathological changes in CHD patients, most of these trials are lack of well-designed
      methodologies and the reliability of results still remains unclear. Therefore, we designed
      this clinical trial, with a randomized, placebo controlled way, to evaluate the curative
      effects of Xuefu Zhuyu capsule(a Chinese herbal medicine)in patients with Post-PCI CHD
      patients and find out whether this effects will be better displayed within subjects
      administered with syndrome-based individualized medication.
    

Intervention name(s): Xuefu Zhuyu Capsules Plus Placebo of Sheng Mai Capsules,; Sheng Mai Capsules Plus Placebo of Xuefu Zhuyu Capsules; Placebo of Xuefu Zhuyu Capsules Plus Placebo of Sheng Mai Capsules
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 3# XFZY capsules plus 3# placebo of SM capsules, po, Tid, for 4 weeks; 3# SM capsules plus 3# placebo of XFZY capsules, po, Tid, for 4 weeks; 3# Placebo of XFZY capsules plus 3# placebo of SM capsules, po, Tid, for 4 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Coronary Heart Disease; PCI; Traditional Chinese Medicine; Quality of Life
Evaluation of Accuracy of Guardian Sensor 3 in Diabetes Patients on Peritoneal Dialysis
Condition: Diabetes Mellitus (Diagnosis); End Stage Renal Disease; Dialysis
MeSH terms: Kidney Failure, Chronic; Diabetes Mellitus
Study type: Observational

Summary: 
      Assessment of performance (precision and accuracy) of Guardian Sensor™ 3 as compared with a
      gold standard reference laboratory method (YSI glucose) in diabetes patients on peritoneal
      dialysis.
    


Intervention name(s): Continuous glucose monitoring system
Intervention type(s): Device
Intervention description(s): Medtronic Guardian Connect with Guardian Sensor 3
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Diabetes patients on continuous ambulatory peritoneal dialysis
A Study Evaluating the Safety and Efficacy of BGC20-0582 Lice Treatment Gel for Head Lice Infestation
Condition: Pediculus Humanus Capitis; Head Lice
MeSH terms: Lice Infestations; Parasitic Diseases
Study type: Interventional
Phase: Phase 2

Summary: 
      The main purpose of this study is to investigate the safety and efficacy of an
      investigational treatment for head lice infestation against a placebo.
    

Detailed description: 
      The main purpose of this study is to investigate the safety and efficacy of an
      investigational treatment for head lice infestation against a placebo.
    

Intervention name(s): Placebo; BGC20-0582
Intervention type(s): Drug; Drug
Intervention description(s): Vehicle Only; BGC20-0582 is a topical gel formulation of a naturally derived product. Subjects are treated either once (day 1) or twice (day 1 and 7) with either placebo or BGC20-0582 at one of the three concentrations. Following application of the BGC20-0582 lice treatment gel of placebo the product is rinsed from the subjects hair.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Head Lice; Lice Infestation; Pediculosis; Pediculosis Capitis
A Study to Evaluate the Efficacy and Safety of SHR0302 in Patients With Rheumatoid Arthritis
Condition: Rheumatoid Arthritis
MeSH terms: Arthritis; Arthritis, Rheumatoid
Study type: Interventional
Phase: Phase 3

Summary: 
      This study is to evaluate the efficacy and safety of different doses of JAK1 inhibitor
      SHR0302 in subjects with moderate to severe active rheumatoid arthritis who had inadequate
      response to conventional synthetic DMARDs.
    


Intervention name(s): SHR0302; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): The placebo group will take drugs orally for 24 weeks, and then switch to SHR0302 dose1 for 28 weeks, in the meanwhile, SHR0302 dose1 group and SHR0302 dose2 group will continue taking drugs for the whole 52 weeks.; The placebo group will take drugs orally for 24 weeks, and then switch to SHR0302 dose1 for 28 weeks, in the meanwhile, SHR0302 dose1 group and SHR0302 dose2 group will continue taking drugs for the whole 52 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
To Test for Photo Allergy Reaction of Sunscreens
Condition: Photoallergy
MeSH terms: Dermatitis, Photoallergic
Study type: Interventional

Summary: 
      The primary objective of this tudy was to evaluate the potential of photoallergy of of sun
      care products Sun Protection Factor (SPF) 50 Y65 110, SPF 50 Y51 002, and SPF 15 V27 104
      application compared to that of a negative control (0.9% sodium chloride, NaCl) and followed
      by irradiation with UV A and UVB.

      The secondary objective aims for evaluation of the safety of SPF 50 Y65 110, SPF 50 Y51 002,
      and SPF 15 V27 104 combined with ultraviolet (UV) A/B irradiation by monitoring adverse
      events (AEs) throughout the study.
    


Intervention name(s): SPF 50 Y65 110 (BAY987519); SPF 50 Y51 002 (BAY987519); SPF 15 V27 104 (BAY987519); Sodium chloride [NaCl]
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Application of 200 µL in an occlusive patch of Webril (0.150 ± 0.010 mg) compared to that of a negative control (0.9% sodium chloride, NaCl) and followed by irradiation with UV A and UVB.; Application of 200 µL in an occlusive patch of Webril compared to that of a negative control (0.9% sodium chloride, NaCl) and followed by irradiation with UV A and UVB.; Application of 200 µL in an occlusive patch of Webril compared to that of a negative control (0.9% sodium chloride, NaCl) and followed by irradiation with UV A and UVB.; Negative control (200 µL, 0.9% sodium chloride [NaCl]) after a single 24 h application of test materials followed by irradiation with ultraviolet A (UVA) and ultraviolet B (UVB).
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Other
Accuracy of SpO2 for Noninvasive Pulse Oximeter Sensor (RD DCI)
Condition: Healthy
Study type: Interventional

Summary: 
      In this study, the level of oxygen within the blood will be reduced in a controlled manner by
      reducing the concentration of oxygen the study volunteer breathes. The accuracy of a
      noninvasive pulse oximeter sensor will be assessed by comparison to the oxygen saturation
      measurements from a laboratory blood gas analyzer.
    


Intervention name(s): RD DCI Sensor
Intervention type(s): Device
Intervention description(s): Noninvasive pulse oximeter sensor
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Balloon-Stent Kissing Technique Versus Jailed Wire Technique for the Coronary Bifurcation Lesions
Condition: Coronary Artery Disease
MeSH terms: Coronary Artery Disease
Study type: Interventional
Phase: Early Phase 1

Summary: 
      To compare the immediate and long-term clinical outcomes between Balloon-Stent Kissing
      Technique (BSKT) and Jailed Wire Technique (JWT) for the interventional treatment of coronary
      bifurcation lesions.
    

Detailed description: 
      Coronary bifurcation lesions account for 15-20% of percutaneous coronary interventions
      (PCIs)[1-2]. They have lower success rate after operation, higher re-stricture ratio by
      radiography and frequent complications, which result in adverse clinical outcomes as compared
      to non-bifurcation lesions[3-5]. Secure and efficient treatment strategies for PCI and
      bifurcation lesions are research hotspots for cardiovascular surgeons. Single-side stand
      strategy (main-support implantation stand or side-support implantation stand when necessary)
      is currently preferred for bifurcation lesions[2,6]. However, as main-support implantation
      stand could lead to plaque transposition, bifurcation ridge excursion and side a sandwich,
      the side openings could become narrower or even blocked[7]. In 2011, our centre initiated the
      use of balloon-stent kissing technique (BSKT)[8] to protect the side branch, which has higher
      success rate after operation, lower block ratio of side branch and lower incidence of
      perioperative adverse events, which led to immediate clinical effect. This study compared
      BSKT versus Jailed Wire Technique (JWT) in the interventional treatment of coronary
      bifurcation lesions to further clarify BSKT's efficacy and advantages.
    

Intervention name(s): Balloon-Stent Kissing technique; Jailed Wire technique
Intervention type(s): Procedure; Procedure
Intervention description(s): All patients underwent coronary angiogram that confirmed true bifurcation lesions, and received PCI treatment,Balloon-Stent Kissing Technique (BSKT)for the interventional treatment of coronary bifurcation lesion; All patients underwent coronary angiogram that confirmed true bifurcation lesions, and received PCI treatment, Jailed Wire technique(JWT) for the interventional treatment of coronary bifurcation lesion
Allocation: Randomized
Intervention model: Sequential Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
A Multi-centre Study Comparing the Effects of AZD2927 and Placebo on the Electrical Activity in the Heart in Patients
Condition: Arrhythmia
MeSH terms: Arrhythmias, Cardiac
Study type: Interventional
Phase: Phase 2

Summary: 
      Medical Products Agency
    

Detailed description: 
      -  A Multi-Centre, Double-Blind, Randomised, Placebo-Controlled Phase II Study to Assess
           the Effects on Atrial and Ventricular Refractoriness of an Intravenous Infusion of
           AZD2927 in Patients Undergoing an Invasive Electrophysiological Procedure.

        -  The study has an adaptive design. In the 1st dose group the planned number of randomised
           patients is 24. The tentative number of randomised patients in the optional 2nd dose
           group is 12, 24 or 36 and thus a total maximum of 60 patients will be randomised in the
           study.
    

Intervention name(s): AZD2927; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): A single dose of AZD2927 administered as an iv infusion; A single dose of placebo administered as an iv infusion
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: Atrial refractoriness; cardiac electrophysiology; IKACh
Novel MRI ANd Biomarkers in GOlimumab-treated Patients With Axial Spondyloarthritis
Condition: Axial Spondyloarthritis
MeSH terms: Spondylitis; Spondylarthritis; Axial Spondyloarthritis
Study type: Observational

Summary: 
      The study investigates different criteria for remission based on MRI and circulating
      biomarkers for inflammation, cartilage, connective tissue and bone turnover in patients with
      axial spondyloarthritis treated with Golimumab. Furthermore, the study also investigates
      factors that affect disease activity, function and participation by use of different
      questionnaires.
    


Intervention name(s): Treatment
Intervention type(s): Drug
Other intervention name(s): Treatment: Injection Golimumab 50 mg every month on the same date
Intervention MeSH terms: Golimumab
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with axial spondyloarthritis with moderate to high disease activity (Bath
        Ankylosing Spondylitis Disease Activity Index (BASDAI) at least 40 mm), who are going to
        start treatment with TNF inhibitor.
Improving Neurodevelopment in Adolescents With Congenital Heart Disease
Condition: Congenital Heart Disease; Neurodevelopment; Executive Function; Working Memory Training; Infant Open-heart Surgery
MeSH terms: Heart Diseases; Heart Defects, Congenital
Study type: Interventional

Summary: 
      Executive dysfunction can profoundly impact all dimensions of a child's development.
      Impairments in executive function are a central component of the neurodevelopmental phenotype
      associated with CHD, and manifest as behavioral dysregulation and problems with attention,
      working memory, and organization/planning abilities. Identifying effective treatment
      strategies is vital for providing optimal care for these patients. The Cogmed executive
      function intervention, an evidence-based computerized neurocognitive program, improves
      outcomes in several pediatric populations. The investigators propose to conduct a pilot study
      to evaluate its efficacy in reducing morbidities in patients with CHD. This is a single
      center, single blinded 2-arm randomized controlled trial to test the immediate post-treatment
      and 3-month follow-up efficacy of Cogmed intervention versus standard of care in adolescents
      with CHD.
    


Intervention name(s): Cogmed Working Memory Training
Intervention type(s): Behavioral
Intervention description(s): Cogmed Working Memory Program will be used as a computerized home-based intervention. Families will receive a link for downloading a web-based software program. The program will be installed on a computer at a family's home by a research assistant. Parents and adolescents will be actively involved, and during the installation session, adolescents will complete several practice trials. The 25 sessions will be completed individually by the adolescent with parental supervision. For the first 5 sessions, the participant trains on the same set of games; on the 6th session and every 5th session thereafter, a new task is introduced and replaces one of the initial tasks. At the end of each session, the adolescent can play an age-appropriate computerized game as a reward. After each session, results are uploaded by parents to a secure website, to keep track of the participant's progress. Families will be contacted weekly to check program function and discuss concerns.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Other
Buddy Taping Compared to Splint Immobilization for Displaced Paediatric Finger Fractures
Condition: Fracture Finger
MeSH terms: Fractures, Bone
Study type: Interventional

Summary: 
      Fracture immobilization with Buddy taping is not inferior to Splint immobilization for
      non-displaced extra-articular paediatric finger fractures. However, whether the same applies
      for reduced finger fractures is unclear.
    

Detailed description: 
      Displaced fractures will be reduced in the paediatric ED by Emergency physicians. After
      fracture reduction, fracture immobilization will either be done with a Splint immobilization
      or a fingertaping. After 4 and 21 days, clinical and radiographic controls will take place at
      the Hand surgery outpatient clinic.
    

Intervention name(s): fracture immobilization after reduction of displaced finger fractures
Intervention type(s): Procedure
Intervention description(s): After closed reduction of a displaced finger fracture, fracture immobilization with either Buddy taping or Splint immobilization
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Respiratory Exercises Versus Manual Therapy and Respiratory Exercises in Moderate Smokers
Condition: Manual Therapies; Respiratory Muscle Training; Exercise Therapy; Inspiratory Capacity
MeSH terms: Respiratory Aspiration
Study type: Interventional

Summary: 
      The aim of this study is to assess if an intervention of manual therapy and motor control
      exercises combined with an inspiratory muscle training program is more effective than an
      inspiratory muscle training program alone in increasing the maximum inspiratory pressure in
      moderate smokers. In addition, the study pretends to evaluate the changes caused by the
      intervention regarding possible postural changes and thoracic diameter.
    


Intervention name(s): Inspiratory Muscle training; IMT + Manual Therapy and Motor Control Exercise
Intervention type(s): Other; Other
Intervention description(s): This protocol will be performed using the Powerbreathe classic level 1 device and Yoga Respiratory Exercises (Pranayama); The Inspiratory Muscle Training protocol will be performed using the Powerbreathe classic level 1 device and Yoga Respiratory Exercises (Pranayama). Manual Therapy and Motor Control Exercises will consist of joint mobilization/manipulation and exercises in the neck and thoracic regions
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Smokers; Maximum Inspiratory Pressure