Exercise Training in Pediatric-Onset Multiple Sclerosis Patients
Condition: Pediatric Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Sclerosis
Study type: Interventional

Summary: 
      Multiple sclerosis is one of the leading causes of disability in young adults. It is known
      that patients with pediatric onset multiple sclerosis (POMS) experience their first
      demyelinating attack before the age of 18. However, studies conducted with individuals with
      pediatric onset of multiple sclerosis have been reported to be few and have affected
      parameters such as physical activity, fatigue balance and quality of life. Therefore, this
      study is planned to consist of two stages. These are the following stages;

        1. Assessment of people with pediatric onset multiple sclerosis with the evaluation methods
           detailed below. After these evaluations, the relationship between the 6-minute walk test
           performance of the patients and other evaluations will be examined. Within the scope of
           the project, a publication will be prepared and uploaded with the data obtained from
           this stage.

        2. The patients are divided into two groups, one group is included in the online exercise
           program, and the other group is included in the exercise program after being put on the
           waiting list.
    

Detailed description: 
      People with pediatric onset multiple sclerosis (POMS) experience various sensory, motor,
      cerebellar and cognitive dysfunctions due to the destruction of the central nervous system.
      These disorders may cause limitation of physical activity in people with POMS. In a study
      comparing people with POMS with monophasic acquired demyelinating syndrome (mono-ADS) and
      healthy controls in terms of physical activity levels, it was reported that people with POMS
      performed less physical activity compared to other groups. In addition, it has been reported
      that people with POMS have increased complaints such as depression and fatigue and their
      quality of life decreases. The aim of this study is to (1) investigate functional exercise
      capacity and its relationship between physical activity level, muscle strength, balance,
      fatigue and quality of life in POMS patients and (2) examine the effect of online exercise
      training on physical activity, balance, fatigue and quality of life in POMS patients.
      Participants will be randomly divided into two groups, the online exercise program group and
      the control group, after the evaluations. Participants in the online exercise program group
      will be given a treatment protocol consisting of aerobic exercise and strengthening exercises
      in the presence of a physiotherapist for a total of 8 weeks, 1 hour on 2 days a week. The
      exercise program will be created according to the condition of the people and progression
      will be provided every 2 weeks. After the exercises are completed, cooling will be done with
      stretching exercises. Participants in the control group will be put on the waiting list after
      all assessment methods are applied and will be re-evaluated at the end of 8 weeks.
      Application of the exercise training online will prevent the difficulties of continuing the
      exercise program due to transportation problems, disability level or pandemic and will
      facilitate the participation of people with POMS in the study.
    

Intervention name(s): Exercise Trainning; Control Group
Intervention type(s): Procedure; Other
Intervention description(s): Participants in the online exercise program group will be given a treatment protocol consisting of aerobic exercise and strengthening exercises in the presence of a physiotherapist for a total of 8 weeks, 2 days a week for 1 hour. Before starting the exercise, the risk of possible injury will be minimized by doing warm-up exercises and preparations will be made to start the exercise. Then, the exercise program will be started with aerobic exercise. Strengthening exercises will be planned for large muscle groups, targeting body parts such as hips, knees, shoulders, abdomen and trunk. In exercises, it is planned to do 2 sets of 10-15 repetitions using elastic band, free weights or body weight. The exercise program will be created according to the condition of the people and progression will be provided every 2 weeks. After the exercises are completed, cool down will be done with relaxation and stretching exercises.; Participants in the control group will be put on the waiting list after all assessment methods have been applied and will be re-evaluated at the end of 8 weeks. After the final evaluations, they will be directed to the exercise group.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Physical Activity; Physiotherapy; Degenerative diseases; Exercise