bioihbjkbjnl/mcl2 huggingface dataset:
Therapeutic Dance Intervention for Children With Cerebral Palsy
Condition: Cerebral Palsy
MeSH terms: Cerebral Palsy
Study type: Interventional

Summary: 
      Children with cerebral palsy (CP) have motor impairments that make it challenging for them to
      participate in standard physical activity (PA) programs. There is a need to evaluate adapted
      PA programs for this population. Dance can promote coordination, posture, muscle strength,
      motor learning, and executive functioning. This pilot study evaluated the feasibility and the
      effects of a new therapeutic ballet intervention specifically designed for children with CP
      on physiological and executive functions outcomes.
    

Detailed description: 
      8 children with CP (9-14y/o; 75% female) participated in a six-week therapeutic ballet
      program. Participants had body composition (DXA), muscle strength (hand-grip dynamometer),
      habitual physical activity, gait and selective motor control functions, and executive
      function tasks before and after the intervention. Follow-up assessments of habitual physical
      activity, gait and executive functions were completed four to five week post-intervention.
    

Intervention name(s): Therapeutic Dance
Intervention type(s): Other
Intervention description(s): Participants attended therapeutic ballet sessions three times per week for six weeks.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Validity of Sentinel Lymphnode Biopsy After Neoadjuvant Chemotherapy Cancer Patients With Radiologically Positive Axillary Lymph Nodes
Condition: Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Observational

Summary: 
      Sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NAC) is currently
      debatable. It is possible that the tumor response to chemotherapy may alter the lymphatic
      drainage thus causing lower SLN identification rate and higher false negative rate. Further,
      the response of NAC can be different in each lymph nodes. It is doubtful whether SLNB can
      accurately predict axillary lymph node (ALN) status after NAC. The aim of this study to
      determine the identification rate, the false-negative rate, and the accuracy of SLNB after
      NAC for node positive breast cancer.
    


Intervention name(s): Sentinel lymph node biopsy; Neoadjuvant chemotherapy; complete axillary lymph node dissection; positron emission tomography and ultrasonogram
Intervention type(s): Procedure; Drug; Procedure; Procedure
Intervention description(s): Sentinel lymph node biopsy after neoadjuvant chemotherapy for the patients with clinically positive-nodes at presentation; Neoadjuvant chemotherapy for breast cancer patients with clinically positive-node at initial diagnosis; Complete axillary lymph node dissection after sentinel node biopsy for estimation of false-negative rate of sentinel node biopsy; Routine evaluation of axillary nodal status using 18-fluorodeoxyglucose positron emission tomography and ultrasonogram before and after chemotherapy
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Advanced breast cancer patients with node-positive proved in preoperative imaging study
      
Keywords: sentinel lymph node biopsy; neoadjuvant chemotherapy; breast cancer; locally advanced breast cancer; positive axillary lymph node; negative conversion
An 8 Week Depression Study In Adults Diagnosed With Major Depressive Disorder
Condition: Major Depressive Disorder (MDD)
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 2

Summary: 
      A Placebo Controlled Study Evaluating Efficacy, Safety and Tolerability of Radafaxine in
      Patients with Major Depressive Disorder (MDD)
    


Intervention name(s): Radafaxine
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: GW353162; Major Depressive Disorder; MDD
A Study of Galcanezumab in Participants With Chronic Cluster Headache
Condition: Chronic Cluster Headache
MeSH terms: Cluster Headache; Headache
Study type: Interventional
Phase: Phase 3

Summary: 
      The main purpose of this study is to evaluate the efficacy of the study drug known as
      galcanezumab in participants with chronic cluster headache.
    


Intervention name(s): Galcanezumab 300 mg; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Administered SC; Administered SC
Other intervention name(s): LY2951742
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Investigation of Seasonal Variations of Brain Structure and Connectivity in SAD
Condition: Seasonal Affective Disorder; Major Depressive Disorder; Neuroimaging
MeSH terms: Depressive Disorder; Depressive Disorder, Major; Mood Disorders; Seasonal Affective Disorder
Study type: Interventional

Summary: 
      Seasonal Affective Disorder (SAD) is a subtype of Major Depressive Disorder, characterized by
      a recurrent temporal relationship between the season of year, the onset and the remission of
      a major depressive episode. Estimates of the annual prevalence state that 1-6% of the
      population will develop SAD with the larger prevalences found at greater extremes in
      latitude. SAD is most likely triggered by the shortening photoperiod experienced in the
      winter months leading to a deterioration of mood. Recent cross-sectional neuroimaging studies
      have found cellular and neurotransmitter changes in response to seasonality, ultimately
      having an impact on the affect of patients. Conversly, this study aims to investigate the
      changes in neurocircuitry related to depression and euthymic states. Patients with SAD offer
      a unique ability to study these changes since they have predictable triggers for the onset of
      depression (i.e. the winter months) and remission (i.e. the summer months).
    


Intervention name(s): Bright Light Therapy
Intervention type(s): Device
Intervention description(s): Light box that emits light at 10,000 lux or higher and has been demonstrated to regulate circadian rhythm that is aberrant in the SAD population
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
The Effect of Bilateral Sphenopalatine Ganglion Block on Postoperative Pain in Patients to be Subject to Septorhinoplasty Surgery
Condition: Anesthesia of Mucous Membrane
MeSH terms: Ganglion Cysts; Pain, Postoperative
Study type: Interventional

Summary: 
      The aim of this study is to examine the effects of bilateral sphenopalatine ganglion block on
      surgical conditions, hemodynamics, intraoperative and postoperative analgesic use, recovery
      characteristics, and postoperative pain during septorhinoplasty under general anesthesia. The
      study was planned as double-blind, randomized, controlled. 72 patients who will undergo
      septorhinoplasty surgery will be collected. (g power analysis was performed.) Evaluation of
      the effectiveness of bilateral sphenopalatine ganglion block was planned. Patients will be
      divided into 2 equal groups (36 patients). After the induction of general anesthesia, one
      group (Group: 1) will be administered 8mg dexamethasone and 10mg bupivacaine submucosal, the
      other group (group:2) will be administered 4 cc saline. aspects will be evaluated.
    


Intervention name(s): Bilateral endoscopic sphenopalatine ganglion block; placebo
Intervention type(s): Procedure; Procedure
Intervention description(s): After the induction of general anesthesia, one group (Group: 1) will be administered 8mg dexamethasone and 10mg bupivacaine submucosal,; Placebo group (group:2) will be administered 4 cc saline. aspects will be evaluated.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: sphenopalatine ganglion block; septhorhinoplasty; general anesthesia
The Efficacy of Derotation Banding on Outcome Measures in Children With Cerebral Palsy
Condition: Cerebral Palsy, Spastic
MeSH terms: Paralysis; Cerebral Palsy
Study type: Interventional

Summary: 
      The aim of the study is to compare the conventional rehabilitation program and derotation
      taping applied with Kinesio Tex tape in addition to conventional rehabilitation in children
      with hemiplegic or monoplegic cerebral palsy with femoral internal rotation deformity.
    

Detailed description: 
      Conventional rehabilitation (CR) practices will be applied to the control group. Conventional
      rehabilitation (KT) application will be applied to the study group in addition to Kinesio Tex
      tape derotation banding. With the kinesio tape application, it is aimed to provide
      economical, ergonomic and effective support to the patients in non-clinical times. It is
      aimed to evaluate the patients' balance, quality of life, performance test, spasticity level
      and gait quality.
    

Intervention name(s): Kinesio Taping; Conventional Rehabilitation
Intervention type(s): Other; Other
Intervention description(s): Derotation taping with Kinesio Tex is applied to the patients through a pediatric physiotherapist.; Conventional rehabilitation program is applied to the patients through a pediatric physiotherapist
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomised controlled trial
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Kinesio taping; Cerebral palsy
Effects of Whole Egg Consumption on Inflammation, Mood, and Recovery in Collegiate Female Gymnasts
Condition: Inflammation
MeSH terms: Inflammation
Study type: Interventional

Summary: 
      The objectives were to investigate the effects of whole egg consumption by collegiate female
      gymnasts on inflammatory markers, mood, and recovery.
    


Intervention name(s): Whole egg consumption
Intervention type(s): Other
Intervention description(s): The participants in the whole egg group consumed two whole eggs immediately after exercise.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Comparing Hypofractionated Radiotherapy Boost to Conventionally Fractionated
Condition: Prostate Cancer
MeSH terms: Prostatic Neoplasms
Study type: Interventional

Summary: 
      The main purpose of study is to compare the effectiveness of Hypofractionated IMRT boost
      Radiotherapy to Conventional IMRT boost Radiotherapy for high-risk prostate cancer patients
      combined with Androgen Deprivation Therapy.
    

Detailed description: 
      Additional objectives of the study for high-risk (non-metastatic) prostate cancer patients
      are as follows:

        1. Analysis of number of circulating tumor cells in peripheral blood as a
           prognostic/predictive factors for survival.

        2. Analysis of miRNA expression levels (100, 141 and 143) in peripheral blood as a
           prognostic and predictive factors.

        3. Evaluation of the usefulness expression of selected proteins (PTEN, SMAD4, Cyclin D1,
           SPP1) as prognostic and predictive factors.

        4. Evaluation of the usefulness of the expression level of antigen-specific T cells, B-and
           NK cells as a prognostic factors.

        5. Evaluation of usefulness of the fiducial markers for localizing the prostate gland
           position during irradiation for the selected control imaging methods (2DkV, CBCT, MVCT).
    

Intervention name(s): Hypofractionated IMRT boost radiotherapy; Conventional Fractionated IMRT boost radiotherapy
Intervention type(s): Radiation; Radiation
Intervention description(s): All patients included into this arm are irradiated to 46 Gy a 2 Gy fraction to the whole pelvis and seminal vesicles and prostate gland (I phase) and than the boost dose is limited to the prostate gland with some part of seminal vesicles with hypofractionated dose of 7.5 Gy in two fractions (II phase) to the total dose of 61 Gy. Additionally all patients received neoadjuvant Androgen Deprivation Therapy (3-4 months prior starting radiotherapy) and during radiotherapy and during the follow-up up to 24 months.; All patients included into this arm are irradiated to 46 Gy a 2 Gy fraction to the whole pelvis and seminal vesicles and prostate gland (I phase) and than the boost dose is limited to the prostate gland with some part of seminal vesicles with conventional fractionated dose of 2 Gy in 15 fractions (II phase) to the total dose of 76 Gy. Additionally all patients received neoadjuvant Androgen Deprivation Therapy (3-4 months prior starting radiotherapy) and during radiotherapy and during the follow-up up to 24 months.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: high risk prostate cancer radiotherapy hypofractionation
Alzheimer's Disease and Physiological, Cognitive Function and BDNF Levels of Plasma Adaptation After Exercise Training
Condition: Alzheimer's Disease
MeSH terms: Alzheimer Disease
Study type: Interventional

Summary: 
      Alzheimer's disease (AD) is a neurodegenerative disease leading to one of the most common
      forms of dementia in humans and memory disorder is one of the first symptoms that lead to
      diagnosis.
    

Detailed description: 
      Present in greater amounts in the regions of the hippocampus and cortex, the Brain-derived
      neurotrophic factor (BDNF) is essential to both learning and memory processes. This protein
      is found in lower amounts in people with AD. Acute physical activity of moderate to vigorous
      intensity would increase the levels of plasma BDNF whether for a healthy person or a person
      with AD. Nevertheless in rest, healthy people have higher level of BDNF than individuals with
      AD. There are no studies on the effect of chronic exercise based on BDNF level at rest in
      people with AD. In a hypothetical endurance training of 18 sessions, whether interval or
      continuous training the levels of BDNF would increase in people with AD at rest. Their
      physiological and neuropsychological performances would also show a rise.
    

Intervention name(s): Endurance Training; therapeutic education meetings
Intervention type(s): Device; Other
Intervention description(s): 40 people will submitted to endurance training: 20 will perform a continuous training and 20 will perform an interval training. The variables that will be analyzed are maximum aerobic power, endurance, heart rate, prehension strength, Mini-Mental State Examination (MMSE), REY's test, biological examination and level of BDNF plasma, before and after the intervention and one month after the end of the intervention and one month after the end of the intervention.; Group of 20 people will be the control group and will not perform ET. However, they will have 9 therapeutic education meetings.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: endurance training; BDNF analysis; cognitive function; physiological abilities
Diaphragm's Manual Therapy in Patients With Chronic Neck Pain
Condition: Neck Pain
MeSH terms: Neck Pain
Study type: Interventional

Summary: 
      The aim of this study is to evaluate the effect of diaphragm's manual therapy in addition to
      cervical spine manual therapy in terms of pain, cervical spine range of motion, trigger
      points pain pressure threshold, disability and quality of life in patient with chronic
      aspecific neck pain.
    


Intervention name(s): Real Treatment Group; Sham Treatment Group
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Real Diaphragm manoeuvres The experimental manoeuvres include the Doming The Diaphragm Technique as described by Digiovanna (2004), Chila (2011) and Yao (2014) and the Manual Diaphragm Release Technique as described by Ricard (2009), De Coster (2005) and Roha (2015). Both manoeuvres are performed in two sets of 10 repetitions, within a 1-minute interval.
Multifaced physiotherapy/osteopathic treatment includes: vertebral mobilisations (C0-D1), high-velocity low-amplitude (HVLA) thrusts of the cervical spine, soft tissue techniques; Sham Diaphragm manoeuvre: the physiotherapist will simply lie hands on the rib cage, and rest along the anterolateral costal margin below rib 7, during normal breathing of the patient for 40 breathes.
Multifaced physiotherapy/osteopathic treatment includes: vertebral mobilisations (C0-D1), high-velocity low-amplitude (HVLA) thrusts of the cervical spine, soft tissue techniques
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Cervical spine;; Diaphragm;; Manual Therapy; Pain; Range of Motion
GCF Levels of IL-1β and IL-6 in Gingivitis and Stage III-Grade C Periodontitis
Condition: Periodontitis
MeSH terms: Gingivitis; Periodontitis
Study type: Observational

Summary: 
      Periodontal diseases are chronic diseases that occur as a result of a violation of the
      balance between microbial dental plaque and the host response. Gingivitis is a disease
      characterized by inflammation of the gingiva that occurs in one or more areas without loss of
      attachments.1 in periodontitis, an inflammatory event that begins in the gingiva along with
      gingivitis spreads to the periodontal ligament, alveolar bone and soft tissues that support
      the tooth, causing the destruction of these structures.2 Cytokines are low molecular weight
      proteins that participate in the initial and active stages of inflammation and immunity. In
      periodontal disease pathogenesis, cytokine response has been reported to play a very critical
      role in determining disease progression.3 IL-1beta and IL-6 are key cytokines in chronic
      inflammatory diseases and have the potential to initiate bone loss and tissue destruction
      seen in periodontal disease.4the purpose of this study; it is to determine the degree of
      inflammation and periodontal destruction by determining the levels of IL-1beta and IL-6
      cytokines in the gingival crevicular fluid of periodontal healthy and diseased individuals.
    

Detailed description: 
      Periodontal measurement were done at 6 sites per tooth After clinical evaluation, individuals
      were divided into 3 groups

        1. Healthy control groups:

           clinically healthy gingiva

        2. Gingivitis groups:

           BOP score of 10% or greater and PD≤3mm

        3. Periodontitis groups:

      AL ≥5 mm, PD≥6 mm and tooth loss due to periodontitis of ≤4. GCF samples were collected using
      strips.
    

Intervention name(s): gingival crevicular fluid
Intervention type(s): Diagnostic Test
Intervention description(s): GCF samples were collected in the morning hours 24-48 hours after clinical periodontal measurement.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        individuals who have periodontal disease will be selected
      
Biospecimen description: 
      Gingival crevicular fluid
    
Keywords: periodontal disease; periodontitis; gingivitis; cytokines
Cervical Epidural Waveform Analysis Using Pressure Monitoring Kit
Condition: Analysis, Event History
Study type: Observational

Summary: 
      The purpose of this study is to analyze the reliability of epidural wave form during
      cerivical epidural injection.
    

Detailed description: 
      The epidural space can be confirmed by loss of resistance (LOR) technique. However, LOR has
      very low specificity, although its sensitivity is high. Especially, cysts between ligaments,
      clefts in ligamentum flavum, paraspinal muscle and nonspecific spaces between muscles make
      false LOR.

      Epidural wave form analysis (EWA) is very simple and reliable method which can substitue the
      LOR technique. If the epidural needle is located correctly in the epidural space, the
      investigators can observe a pulsatile wave and this pulsatile wave corresponds to arterial
      wave. Generally, sensitivity of EWA through needle is known to be superior to the sensitivity
      of EWA through catheter and most studies were focused on catheter EWA.

      Cervical epidural space shows high false LOR rate and Lee et al demonstrated that false LOR
      at cervical epidural space was 68.7%. Therefore, nonspecificity of LOR technique require
      substitution method which can confirm epidural space.
    

Intervention name(s): cervical epidural injection
Intervention type(s): Procedure
Intervention description(s): sensitivity, specificity, positive predictive value, negative predictive value
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Patients who complain chronic neck pain due to cervical spinal disease or acute herpes
        zoster
      
Keywords: cervical epidural space; wave form analysis
Comparison of MMFS Dosages in Older Adults
Condition: Anxiety; Depression; Sleep Quality; Cognitive Impairment
MeSH terms: Cognitive Dysfunction
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is designed to compare the effectiveness of different doses of brain health
      supplement MMFS relative to placebo on cognition, mood, and sleep quality.
    

Detailed description: 
      This is a phase 2 study in older adults with at least mild progressive behavioral symptoms,
      subjective sleep maintenance problems, and at least mild progressive cognitive deficit. The
      study is a randomized, double-blind, placebo-controlled, three-way crossover design, in which
      participants will receive oral placebo, low dose MMFS, and high dose MMFS twice daily for 6
      weeks. Over three study periods (2 weeks each), subjects will receive two different dosages
      of MMFS (low dose: ~22.5 mg/kg LBM/day and high dose: ~35 mg/kg LBM/day) and placebo. After
      periods 1 and 2 there will be a one week washout period in which the subject will not take
      any study tablets. Randomized patients and their informants (required) will complete 5
      assessments total: at baseline in the clinic (visit 1; prior to taking any study tablets),
      and 4 times at home via online assessments (at the beginning of period 1 and at the end of
      periods 1, 2, and 3. The effectiveness of different MMFS dosages on cognition, mood, and
      sleep quality will be assessed using a Neuropsychological Test Battery, Profile of Mood
      States-Brief Form, daily sleep diaries, and Insomnia Severity Index. The safety profile of
      different MMFS dosages will be determined by monitoring the AE/SAE and subjective remarks
      during the study period. A range of safety and tolerability assessments will also be
      performed (including vital signs and laboratory tests).
    

Intervention name(s): Low Dose MMFS-205-SR; High Dose MMFS-205-SR; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Twice daily, oral 500mg tablets; Twice daily, oral 500mg tablets; Twice daily, oral
Other intervention name(s): L-threonic acid magnesium salt, L-TAMS; L-threonic acid magnesium salt, L-TAMS; inactive sugar pill
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
Keywords: cognition; mood; sleep