bioihbjkbjnl/mcl2 huggingface dataset:
Can Amino Acid Supplementation Augment the Anabolic Response in Tendon After Exercise
Condition: Tendinopathy
MeSH terms: Tendinopathy
Study type: Interventional

Summary: 
      The goal of this study is to determine if an oral provision of amino acids will enhance
      exercise-induced increases in markers of Achilles tendon collagen production.
    

Detailed description: 
      Tendon pain is a common complaint in older adults. The mechanisms contributing to the large
      number of tendon problems in older adults are not known. It has been shown that tendon
      cross-sectional area (CSA) is reduced with aging concurrent with a significant loss of tendon
      collagen. Exercise is used to reverse the loss of muscle mass with aging but surprisingly
      exercise interventions designed to reduce tendon problems in older people are relatively
      unexplored. In young adults, exercise stimulates tendon collagen synthesis and enhances the
      production of growth factors, which stimulate tendon collagen production. It is presumed that
      exercise-induced increase in collagen synthesis contributes to the increase in tendon
      stiffness and CSA noted in young adults after chronic resistance exercise (RE). In contrast,
      our preliminary work indicates that RE is not effective at reducing the effects of aging on
      tendon. The investigators have demonstrated that 12-weeks of RE does not lead to increases in
      tendon CSA or stiffness, even when skeletal muscle mass and strength are greatly enhanced. To
      prevent tendon injury, greater tendon CSA and stiffness aid in withstanding the force
      generated by trained skeletal muscle. Greater CSA and stiffness also optimize force transfer
      through tendon to maximize musculoskeletal function. Our findings indicate that RE is not an
      optimal intervention for reversing age-related changes in tendon properties. Novel
      interventions are clearly needed that will enhance collagen synthesis leading to an increase
      in tendon stiffness and CSA while also improving skeletal muscle mass and strength in older
      individuals. This study will evaluate the effectiveness of various methods for stimulating
      tendon collagen synthesis during a bout of acute exercise. Specifically, the investigators
      propose two approaches to this problem.

        1. An acute bout of cycling exercise will enhance the release of growth factors leading to
           a larger increase in tendon collagen synthesis.

        2. A bolus of amino acids given orally will increase the release of key stimulators of
           tendon collagen synthesis leading to enhanced collagen synthesis after acute exercise.
    

Intervention name(s): Amino Acids
Intervention type(s): Dietary Supplement
Intervention description(s): Oral bolus of essential amino acids
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: tendon; amino acid; exercise
Effects of One Evening Dose of 3 mg Eszopiclone on Next Day Driving Ability
Condition: Primary Insomnia
MeSH terms: Sleep Initiation and Maintenance Disorders
Study type: Interventional
Phase: Phase 3

Summary: 
      To assess next day driving ability and psychomotor/memory function following a single night
      time dose of eszopiclone in insomnia patients.
    

Detailed description: 
      The study is a single centre, randomised, double blind, placebo controlled 2-way crossover
      design in a group of 32 male and female primary insomnia patients. The medications under
      investigation are eszopiclone and placebo. Patients will receive the study medications and
      placebo on the evening of Day 2 of each treatment period. Performance will be assessed on Day
      3 of each treatment period. Each treatment period will be separated by at least a 7-day
      washout period. This study was previously posted by Sepracor Inc. In October 2009, Sepracor
      Inc. was acquired by Dainippon Sumitomo Pharma., and in October 2010, Sepracor Inc's name was
      changed to Sunovion Pharmaceuticals Inc.
    

Intervention name(s): Eszopiclone; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): eszopiclone 3 mg; Placebo tablet
Other intervention name(s): S-Zopiclone; Lunesta
Intervention MeSH terms: Eszopiclone; Zopiclone
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Mindfulness Interventions and Chronic Widespread Pain in Adolescents
Condition: Fibromyalgia; Chronic Widespread Pain
MeSH terms: Fibromyalgia; Myofascial Pain Syndromes; Chronic Pain
Study type: Interventional

Summary: 
      The primary objective of this study to determine the feasibility and acceptability of a
      mindfulness intervention for adolescents with juvenile fibromyalgia/ chronic widespread pain
      and other similar chronic symptoms.
    

Detailed description: 
      The primary objective is to test the feasibility, safety, tolerability and acceptability of a
      mindfulness meditation intervention for adolescents with juvenile fibromyalgia/chronic
      widespread pain.

      The purpose of the program is to test how effective an 8-week meditation and stress reduction
      class is in helping adolescents with chronic symptoms (including but not limited to
      fibromyalgia or chronic widespread pain, irritable bowel syndrome, joint pain, chronic
      fatigue, and others).

      Participants will attend group sessions led by an instructor experienced in MBSR in an
      academic setting. The mindfulness meditation group sessions will take place at the Yale
      School of Medicine.

      Participants will attend 90-minute weekly group sessions and a 4-hour retreat with
      approximately 6-8 other study participants at Yale School of Medicine. Participants are asked
      to practice at home by listening to pre-recorded 15-20 minute guided meditations.
    

Intervention name(s): Mindfulness Group
Intervention type(s): Behavioral
Intervention description(s): Participants will attend weekly 1-2-hour group sessions (of 6-8 persons) led by a trained expert based on the working MBSR protocol. The weekly sessions will be scheduled in a time mutually convenient for participants and their parent/guardian that will accompany them to each group session. The MBSR group sessions will take place at the Yale School of Medicine.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: fibromyalgia; juvenile fibromyalgia; juvenile primary fibromyalgia syndrome (JPFS); adolescent pain; mindfulness; MBSR
Resin Salve Versus Honey Treatment in Wound Care
Condition: Wound Healing; Wound Infection
MeSH terms: Wound Infection; Wounds and Injuries
Study type: Interventional

Summary: 
      In recent years, salve prepared from Norway spruce (Picea abies) resin and refined honey from
      manuka myrtle (Leptospermum scoparium), has successfully been used in medical context to
      treat both acute and chronic surgical wounds. The objective of this prospective, randomized
      and controlled clinical trial is to investigate healing rate and healing time of surgical
      wounds in patients, who have undergone peripheral vascular surgery, and whose complicated
      wounds are candidate for topical treatment with the resin or honey. In addition, factors
      contributing with delayed wound healing, antimicrobial properties, safety and
      cost-effectiveness of the resin salve and medical honey will be analyzed.
    


Intervention name(s): Abilar 10% resin salve; Activon Tube 25 g
Intervention type(s): Device; Device
Intervention description(s): The resin salve may be spread directly onto the wound, after which the area is covered with a bandage suitable for local wound care. The bandage prohibits salve from moving away from the wound area. If the skin condition is more widespread or contains cavities or fistulae, the salve may be spread as a film with a thickness of at least 1 mm onto a gauze or gauze ribbon that is then used to fill the cavity or fistulae channel. Bandages are changed every 1-3 days, depending on the degree of infection and amount of wound secretion.; Wound care with the medical honey is carried out in the same manner than the resin salve treatment: honey may be spread directly onto the wound and the wound area is covered with a bandage suitable for local wound care. Similarly, if the skin condition is more widespread or wound contains cavities or fistulae, the medical honey may be spread as a film with a thickness of at least 1 mm onto a gauze or gauze ribbon that is then used to fill the cavity or fistulae channel. Bandages are changed every 1-3 days, depending on the severity of infection and amount of wound secretion.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Wound healing; Wound infection; Resin salve; Medical honey
Dietary Guide in Active Older Adult Men
Condition: Men; Diet Modification; Obesity; Overweight; Life Style; Weight Loss
MeSH terms: Overweight; Weight Loss
Study type: Interventional

Summary: 
      The present study aimed to determine the effects of negative-calorie diet supplemented with
      exercise, on weight loss and lipid profile, and to compare its efficiency with low-calorie
      diet with exercise among elderly adult men with abnormal weight gain.
    

Detailed description: 
      Background and Aim: Negative-calorie diet is among the popular dieting guides for weight
      loss; however, there is still little knowledge about this method. The present study aimed to
      determine the effects of negative-calorie diet supplemented with exercise, on weight loss and
      lipid profile, and to compare its efficiency with low-calorie diet with exercise among
      elderly adult men with abnormal weight gain.

      Materials and Methods: Participants included sedentary men (age 45-75 years) with overweight
      or obesity (n=37). They were randomly divided into 2 groups including negative calorie diet
      with exercise, and low-calorie diet with exercise. Of all 37 participants, 30 persons
      completed the treatment. The weight assessment parameters including change in weight and body
      composition, blood sample tests were performed pre- and three month post-intervention.
    

Intervention name(s): NCDsport; LCDsport
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Negative Calorie Diet supplemented with exercise; Low-Calorie diet with exercise
Other intervention name(s): group I; group II
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Caloric Restriction; Diet; Exercise; Obesity; Overweight; Sedentary lifestyle; weight loss; Men
Magnesium Sulphate and Extubation Quality
Condition: Perioperative Complication
Study type: Interventional
Phase: Phase 4

Summary: 
      The investigators aimed to search effect of magnesium Sulfate on extubation quality scores,
      recovery and pain in larynx micro surgery. The patients allocated to two groups to receive
      magnesium sulfate 30 mg/kg in 100 ml saline infusion (maximum 2g) (Group m) or saline 100 ml
      (Group S) before induction of anesthesia. Anesthesia induction performed with propofol 2
      mg/kg, rocuronium 0.6 mg/kg, remifentanil 0.5 µg/kg and general anesthesia maintained with
      total intravenous anesthesia (propofol 3-7 mg/kg, remifentanil 0.05-0.1 µg/kg/min and O2/air
      30/70 mixture) to the all patients. Extubation quality scores, Extubation time, NRS scores
      were assessed.
    

Detailed description: 
      The investigators aimed to search effect of magnesium sulfate on extubation quality, recovery
      feature and complications.98 adult patients scheduled for larynx laser microsurgery were
      included and randomly allocated to two groups to receive magnesium sulfate 30 mg/kg in 100 ml
      saline infusion (maximum 2g) (Group m) or saline 100 ml (Group S) before induction of
      anesthesia. Anesthesia induction performed with propofol 2 mg/kg, rocuronium 0.6 mg/kg,
      remifentanil 0.5 µg/kg and general anesthesia maintained with total intravenous anesthesia
      (propofol 3-7 mg/kg, remifentanil 0.05-0.1 µg/kg/min and O2/air 30/70 mixture) to the all
      patients. Paracetamol 15 mg/kg applied to all patients.Extubation quality score, extubation
      time, stay in postanesthesia unit (PACU) time, numeric rating scale (NRS) and complications
      were recorded.
    

Intervention name(s): Magnesium sulfate; Saline
Intervention type(s): Drug; Drug
Intervention description(s): magnesium sulphate IV 30 mg/kg (10 min) infusion apply to the Group M; 100 ml saline infusion apply to the Group S
Other intervention name(s): Intravenous magnesium infusion; Saline infusion
Intervention MeSH terms: Magnesium Sulfate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Comparison Of Direct Myofascial Release And Bowen's Technique For Non-Specific Neck Pain
Condition: Neck Pain
MeSH terms: Neck Pain
Study type: Interventional

Summary: 
      Neck pain is described as pain in the neck region that may or may not radiate to both the
      upper limbs and that will last for at least one day. Non-specific neck pain is the common
      cause of neck symptoms that is mainly due to mechanical causes, postural problem, depression,
      anxiety or occupational activities. Poor posture causes abnormal muscle loading and muscle
      injury
    

Detailed description: 
      Neck pain is described as pain in the neck region that may or may not radiate to both the
      upper limbs and that will last for at least one day.Poor posture causes abnormal muscle
      loading and muscle injury.It becomes a constant source of neck pain and instability. It
      reduces range of motion and weakens the shoulder and neck muscles. According to a population
      based survey the prevalence of lifetime neck pain ranges from 67% to 87%.

      Trigger points cause myofascial pain syndrome which is among the leading cause of
      non-specific neck pain. Myofascial release technique (MRT) is often used to treat
      non-specific neck pain.Another therapy that focuses on myofascial work is Bowen therapy that
      follows a dynamic approach to release fascia and muscles. The technique involves very gentle
      cross fiber movements that are applied on fascia, muscles, tendons and viscera to induce the
      effect. The technique is applied at specific body regions following specific sequences with
      regular rest intervals that cause fascial stretching. The technique consists of slightly
      picking up muscles and then rolling the muscles to direct them toward a specific region of
      body. The rest periods help the body to integrate and absorb the effects of therapy. The
      sensory impulses caused by the Bowen therapy interact with nervous system and realign and
      correct the disturbed mechanisms.
    

Intervention name(s): Direct myofascial release treatment; Bowen therapy
Intervention type(s): Other; Other
Intervention description(s): Myofascial Release will be applied with Forearm and/or ulnar border of the palm. Deep Pressure will be applied and glided medially towards the base of the neck and/ or towards the upper scapular region; Thumb of the therapist will be placed on the top of the targeted muscle. The skin will be carried away gently from the spine without disturbing the muscle. The thumb was then hooked into the lateral aspect of the muscle to form a pressure on the muscle. Then the thumb will be flattened in the medial direction, when this happened the muscle would plop or respond in some way.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Pain; Range of motion; Myofascial release; Bowen therapy; Anxiety
Effect of Topiroxostat on Urinary Albumin Excretion Early Stage Diabetic Nephropathy and Hyperuricemia With or Without Gout
Condition: Diabetic Nephropathy
MeSH terms: Kidney Diseases; Diabetic Nephropathies; Hyperuricemia
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to investigate the effect of topiroxostat on urinary albumin
      excretion and the safety in patients with early stage diabetic nephropathy and hyperuricemia
      with or without gout. Participants are randomized to placebo (n=20) or topiroxostat (n=40)
      for 28 weeks. The investigational drugs for this study are supplied by FUJI YAKUHIN CO., LTD.
    


Intervention name(s): Topiroxostat BID, (Oral daily dosing for 28 weeks); Placebo BID, (Oral daily dosing for 28 weeks)
Intervention type(s): Drug; Drug
Intervention description(s): The dose of topiroxostat is increased up to 160 mg/day in a stepwise manner.; Subjects randomized to the placebo arm will receive placebo.
Intervention MeSH terms: FYX-051
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Impact of n-3 Polyunsaturated Fatty Acids in a Protein-enriched Diet With Low GI in Type 2 Diabetes Patients
Condition: Overweight; Obese; Insulin Resistance; Diabetes
MeSH terms: Overweight; Insulin Resistance
Study type: Observational

Summary: 
      Type 2 diabetes is tightly associated with overweight and obesity. Inflammatory processes are
      crucial triggers for insulin resistance that paves the way to type 2 diabetes. In a previous
      study the investigators have shown that n-3 polyunsaturated fatty acids diminish adipose
      tissue inflammation in morbidly obese non-diabetic subjects. in this observational study the
      investigators will apply n-3 polyunsaturated fatty acids as addition to a protein-enriched
      diet with low glycemic index to overweight and obese patients with insulin resistance,
      prediabetes and manifest type 2 diabetes over up to 6 months. Primary efficacy parameters are
      changes from baseline in HbA1c and body weight for for type 2 diabetes and all other
      patients, respectively.
    


Intervention name(s): n-3 PUFA in protein-enriched low-GI diet
Intervention type(s): Dietary Supplement
Intervention description(s): 3 g per day n-3 polyunsaturated fatty acids in a protein-enriched low-GI diet
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        overweight to obese insulin resistant, prediabetic and diabetic patients
      
Biospecimen description: 
      serum and plasma samples for biochemical analyses
    
Keywords: observational study
Communication Bridge: A Person-centered Internet-based Intervention for Individuals With Primary Progressive Aphasia
Condition: Primary Progressive Aphasia
MeSH terms: Aphasia; Aphasia, Primary Progressive; Pick Disease of the Brain; Frontotemporal Dementia
Study type: Interventional

Summary: 
      This study will use a randomized controlled trial design to evaluate the effect of two
      evidence-based treatments for adults with mild Primary Progressive Aphasia (PPA). The aim of
      the study is to help us better understand the effects of speech language therapy on
      communication abilities in individuals with PPA.

      Participants with a diagnosis of PPA and their actively-engaged care partners will be
      involved in the study for 12 months. Each participant will receive a laptop equipped with the
      necessary applications and features for the study. Participants will receive 5 evaluations
      and 15 speech therapy sessions with a licensed speech therapist, as well as access to
      Communication Bridge, a personalized web application to practice home exercises that
      reinforce treatment strategies. There are no costs to participate in this study.
    


Intervention name(s): Communication Bridge™; Evidence-Based Impairment Focused
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Evidence-based speech language therapy treatment will be compared and contrasted in the two arms of the study.; Evidence-based speech language therapy treatment will be compared and contrasted in the two arms of the study.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: NIH Stage 2 behavioral clinical trial
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: aphasia; primary progressive aphasia; dementia; communication; frontotemporal dementia; Alzheimer's disease
Effect of TU-100 in Patients With Functional Constipation
Condition: Functional Constipation
MeSH terms: Constipation
Study type: Interventional
Phase: Phase 2

Summary: 
      The primary objective of this study is to evaluate the improvement in the severity of
      constipation (from Baseline to Day 28), determined by the constipation severity instrument
      (CSI) score [1], compared to placebo, following a total daily oral dose of 15 g TU-100
      administered for 28 consecutive days in adult subjects with functional constipation.
    


Intervention name(s): DAIKENCHUTO (TU-100); Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Subjects will be randomized to 15 g/day of TU-100. Dosage is granule. Subjects will ingest two 2.5 g doses of TU-100 three times daily for 34 consecutive days.; Subjects will be randomized to 15 g/day of placebo. Dosage is granule. Subjects will ingest two 2.5 g doses of placebo three times daily for 34 consecutive days.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Gastric Emptying
Remote Monitoring and Social Support for Hypertension Management
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      A 3-arm randomized pilot trial aimed at comparing the effectiveness of different remote
      approaches to improving blood pressure (BP) control.
    

Detailed description: 
      The investigators plan to leverage the Way to Health (WTH) platform to develop and evaluate a
      new HTN service-delivery model that is integrated with routine clinical care at Penn Family
      Care (PFC), an academic family medicine practice in West Philadelphia. Among patients with
      poorly controlled HTN:

        1. The investigators will assess the effects of monitoring blood pressure and medication
           adherence with feedback to the patient and to the clinical practice, as needed if out of
           control.

        2. The investigators will also compare the impact of providing feedback to a social support
           partner with facilitated cheerleading.
    

Intervention name(s): Remote Monitoring; Remote Monitoring + Social Support
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Remote BP monitoring and medication adherence; Remote BP monitoring and medication adherence with enhanced support from a support partner ("facilitated cheerleading")
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Supportive Care