bioihbjkbjnl/mcl2 huggingface dataset:
Exercise-induced Bronchoconstriction Diagnostics: Impact of a Repeated Exercise Challenge Test
Condition: Exercise Induced Bronchoconstriction
Study type: Observational

Summary: 
      The purpose of this study is to increase the knowledge of the possible diagnostic effect of
      exercise induced bronchoconstriction performing a repeated exercise challenge test.
    

Detailed description: 
      Prior studies have shown that the intensity influences the sensitivity of exercise challenge
      tests (ECT) and that a heart rate-based protocol does not ensure sufficient exercise
      intensity to induce bronchoconstriction. It is not common clinical practice to perform a pre
      ECT to establish maximal heart rate or maximal oxygen uptake. The heart rate formula
      recommended by ATS (HRmax= 220-age) is usually applied to determine recommended intensity of
      the ECT. Conducting a second ECT, based on the knowledge of the first test, introduce the
      possibility to adjust the intensity on an individual basis. In addition, based on clinical
      experience, patients may seem reluctant to perform maximal the first time they undergo an ECT
      on a treadmill. The hypothesis is that patients are less reluctant to perform maximal the
      second time they undergo the test when they are more accustomed to the procedure and the
      treadmill by itself.
    

Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Subjects referred to Klinikk for allergi og luftveissykdommer
Ultrasound Guided Versus Landmark Guided Small & Medium Joint Arthrocentesis
Condition: Effusion Joint
MeSH terms: Hydrarthrosis
Study type: Interventional

Summary: 
      Arthrocentesis is the removal of synovial fluid for analysis of pathologic processes. Small &
      medium joint arthrocentesis will be defined as the following joints: elbow, wrist, finger,
      ankle and toe. Ultrasound (US) and landmark (LM) small & medium joint arthrocentesis are both
      performed within the clinical setting. Both techniques are considered standard of care.
      Selection of which technique to use is dependent upon the physician's preference. There is
      currently limited data comparing the two methods. The investigators hope to determine if one
      modality is more effective in terms of success rate, number of attempts, and time to complete
      the procedure.
    

Detailed description: 
      Patients presenting to the Emergency Department who are 18 years old or older, who do not
      belong to a vulnerable group, requiring small or medium joint arthrocentesis will be included
      in this trial. The investigators will randomize each patient into LM vs US. Data collected
      will include number of attempts to tap the joint, success rate, and time for procedure to be
      completed. The arthrocentesis will be performed by PGY-3 residents only. A 21 gauge needle
      will be used for the arthrocentesis.
    

Intervention name(s): Arthrocentesis
Intervention type(s): Procedure
Intervention description(s): Athrocentesis
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Care Provider)
Primary purpose: Treatment
Comparison of C-Mac D Blade and Fastrach Laryngeal Mask Airway on Cervical Spine Motion Conditions
Condition: Intubation Complication; Cervical Discopathy
Study type: Interventional

Summary: 
      In patients with cervical spine disorders or hernia, in-line stabilization and immobilization
      during tracheal intubation is used to avoid neck injury. With direct laryngoscopy
      cranio-cervical motion can result injury. The aim of the study is to compare two different
      device (C-Mac D blade versus fastrach LMA ) regarding cervical motions during intubation.
    

Detailed description: 
      In simulated or clinical settings of restricted neck mobility, videolaryngoscopes and
      fastrach LMA have performed well but neck motion can be occured. Endotracheal intubation will
      be performed under fluoroscopy. In this study the neck motion angles will be investigated
      during intubation . The angles will be assessed on fluoroscopy images. A Angle: Angle of the
      line between occipital protuberance and anterior process of the foramen magnum with the line
      between central point of spinous process C1 vertebrae and the anterior process of foramen
      magnum. The reference line for the occiput is defined as a line between the base of the sella
      and the opisthion (lineA), and the C1 reference line as a line between the lower cortical
      margin of the spinous process (line B). The C2 reference line is defined as a line between
      the anterior , inferior margin of the C2 body and the lower cortical margin of the C2 spinous
      process (lineC). The C5 reference line is a tangent along the superior endplate of the C5
      vertebral body (line D). The groups will be compared statistically.
    

Intervention name(s): C-Mac D Blade; Fastrach LMA
Intervention type(s): Device; Device
Intervention description(s): Videolaryngoscope; Laryngeal mask airway
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: videolaryngoscope; Fastrach LMA; cervical motion
Evaluation of the Mechanism of Action of Platelet Rich Fibrin Matrix (PRFM) in Producing Skin Volume Augmentation
Condition: Aging
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Autologous platelet rich fibrin matrix will release growth factors which could increase the
      production of dermal proteins or affect the vascularity and status of neighboring tissues.
      This study is designed to evaluate the histologic and biochemical effect of injection of
      platelet rich fibrin matrix into the skin.
    

Detailed description: 
      Subjects will be treated with platelet rich fibrin matrix into the skin of the inner aspect
      of the upper arm. Injected areas will be monitored clinically and will also undergo biopsies
      between 30 minutes and 12 weeks after treatment. Specimen of treated areas will undergo
      histologic and biochemical analysis and comparison to standard laboratory control specimen of
      untreated skin.
    

Intervention name(s): Platelet rich fibrin matrix
Intervention type(s): Biological
Intervention description(s): Single treatment with platelet rich fibrin matrix
Other intervention name(s): Selphyl
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: platelet rich plasma; fibrin matrix; dermal filler
Evaluation of the Causes and Disease Processes of Chronic Lung Disease
Condition: Pulmonary Disease
MeSH terms: Lung Diseases
Study type: Observational

Summary: 
      Chronic lung diseases are disorders associated with abnormalities in any of the structures
      involved in the process of breathing and bringing oxygen into the lungs and blood. This
      includes abnormalities in the airways, lungs, blood vessels in and around the lungs, and the
      tissue covering the lungs (pleura).

      The purpose of this research study is to evaluate patients referred to the Cardiovascular and
      Pulmonary Branch of the National Heart, Lung, and Blood Institute (NHLBI) in order to;

        1. Develop a better understanding of the causes and disease processes involved in disorders
           of the lungs

        2. Identify patients eligible to participate in other P-CCMB research studies
    

Detailed description: 
      The chronic lung diseases are those disorders associated with functional and/or structural
      derangement to the alveolar structures, airways, pulmonary blood vessels, pleura and/or
      mediastinum. The purpose of this project is to permit the comprehensive evaluation of
      patients referred to the Pulmonary Branch of the National Heart, Lung, and Blood Institute
      (NHLBI) in order to: (1) develop an understanding of the etiology and pathogenesis of these
      disorders; and (2) identify individuals who will be suitable candidates for other NHLBI
      protocols. Testing and procedures will only be performed when medically indicated for the
      purposes of making a diagnosis or obtaining information likely to be useful in the management
      of the subjects' disease or condition.
    

Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        patients being screened for lung disease
      
Keywords: Computed Tomography; Fiberoptic Bronchoscopy; Pulmonary Function Testing; Cardiopulmonary Exercise Testing; Allergen Skin Testing
Effectiveness of Mechano-Analgesia and Cold Application on Ecchymosis, Pain and Satisfaction at Subcutaneous Heparin Injection
Condition: Injection Site Reaction; Injection Site Bruising
MeSH terms: Ecchymosis; Injection Site Reaction
Study type: Interventional

Summary: 
      Fifty-five patients received three subcutaneous heparin injections (165 injections) by the
      same investigator using additional techniques such as mechano-analgesia and cold application,
      and without any additional techniques.
    

Detailed description: 
      The abdomen was divided into four quarters. The first, second, and third SC heparin
      injections were applied from the right abdominal region using ShotBlocker®, left abdominal
      region with an ice pack, and lower abdominal region without any additional application,
      respectively. All the injection sites were circled using a skin marking pen (r = 5 cm).

      All the injections were administered following a standard procedure. Pain and satisfaction
      were assessed immediately after the injection by using the VAS score. Ecchymosis was assessed
      with an ecchymosis measurement tool at 48 and 60 hours after the injection (Figure 3).
    

Intervention name(s): ShotBlocker; Ice pack
Intervention type(s): Device; Device
Intervention description(s): ShotBlocker is a drug-free tool with no side effects and does not require preparation. It is a flexible, plastic, C-shaped device with a number of short (2 mm) blunt contact points on its back.; Ice pack containing gel
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: subcutaneous heparin; injection pain; ecchymosis
Construction and Application of Precise Health Education Model for Patients With PICC Tube
Condition: Tumor Chemotherapy Patients
Study type: Interventional

Summary: 
      1. In this study, the risk factors leading to catheter-related complications in the daily
           life behavior habits of patients with PICC catheter were identified, refined and
           initially established, and the Delphi method (expert consultation method) was used to
           further identify the existing and potential risk factors leading to PICC
           catheter-related complications in the daily life behavior habits of patients. To develop
           individualized and precise health education programs for risk factors, in order to build
           an accurate health education model centered on improving patients' daily life and
           behavior habits.

        2. To conduct clinical empirical study to evaluate the feasibility and effectiveness of
           precise health education program for PICC patients with catheter, and to observe the
           impact of this health education model on the knowledge, attitude and practice level of
           daily management, self-management efficacy and the incidence of related complications
           after catheter insertion in PICC patients, so as to provide a reference for health
           education of PICC patients.
    


Intervention name(s): Routine health education; Routine health education + precise health education
Intervention type(s): Behavioral; Behavioral
Intervention description(s): The control group received routine health education after catheterization, including introducing the purpose, method, advantages and complications of PICC insertion to patients before catheterization and signing informed consent. During catheterization, PICC assistant explained relevant matters needing attention and cooperative actions to the patient. After catheterization, patients were instructed to carry out grip training and limb activities.; On the basis of routine health education in the control group, the experimental group screened the high-risk behaviors of patients through the questionnaire of daily life behavior habits, and formulated the precise and concrete health education program for their high-risk behaviors
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Physical Activity and Motor Memory in Pedal Dexterity
Condition: Elderly
Study type: Interventional

Summary: 
      The main purpose of this study was to investigate if a six months period of physical
      exercise, could improve motor memory consolidation in elderly people on pedal dexterity
    

Detailed description: 
      34 subjects of both genders, with a mean age of 71 years old participated in the study.
      Subjects were divided in two groups: a control group and an experimental one. Before the
      intervention of physical exercise program, subjects performed a Tapping Pedal Test to measure
      baseline performance. After the intervention, the assessment of the impact of exercise on
      motor memory consolidation was held in three stages: Training; 1 hour after training and 24
      hours after training.
    

Intervention name(s): Regular physical activity in Motor memory consolidation
Intervention type(s): Other
Intervention description(s): After the intervention, the assessment of the impact of exercise on motor memory consolidation was held in three stages: Training; 1 hour after training and 24 hours after training. For the analysis of the results, descriptive and inferential statistics were used.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Efficacy and Safety Study of ABP 215 Compared With Bevacizumab in Patients With Advanced Non-Small Cell Lung Cancer
Condition: Non-small Cell Lung Cancer Metastatic
MeSH terms: Lung Neoplasms; Carcinoma, Non-Small-Cell Lung
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this research study is to compare the effectiveness and safety of ABP 215
      against bevacizumab in men and women with advanced non-small cell lung cancer.
    


Intervention name(s): Carboplatin; Paclitaxel; ABP 215; Bevacizumab
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Administered at an area under the concentration-time curve (AUC) 6 by IV infusion Q3W; Administered 200 mg/m² IV Q3W; Administered 15 mg/kg Q3W by IV infusion; Administered 15 mg/kg Q3W by IV infusion
Other intervention name(s): Paraplatin; Taxol; Avastin
Intervention MeSH terms: Paclitaxel; Bevacizumab; Carboplatin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Post-Marketing Surveillance of Ventavis® in Chinese Patients With Primary Pulmonary Hypertension (PPH)
Condition: Primary Hypertension
MeSH terms: Hypertension, Pulmonary; Familial Primary Pulmonary Hypertension; Pulmonary Arterial Hypertension; Hypertension; Essential Hypertension
Study type: Observational

Summary: 
      The purpose of this study is to demonstrate the safety and efficacy of inhaled Iloprost
      (Ventavis®) among adult Chinese patients with primary pulmonary hypertension, which is in
      compliance with Chinese SFDA regulation.
    


Intervention name(s): Ventavis (Iloprost, BAYQ6256)
Intervention type(s): Drug
Intervention description(s): Iloprost solution for inhalation, BAYQ6256, Synthetic Prostacyclin analog
Intervention MeSH terms: Iloprost
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Adult Chinese patients (age 18-65 male and female) with Primary Pulmonary Hypertension
      
Keywords: Primary Pulmonary Hypertension (PPH)
Origin to Insertion Kinesio Tapping vs Non-Directional Kinesio Tapping on Quadriceps Peak Torque
Condition: Quadriceps Muscle Atrophy
MeSH terms: Muscular Atrophy
Study type: Interventional

Summary: 
      This study was conducted to investigate the effect of kinesio tapping on electrical activity
      and peak torque of quadriceps during concentric and eccentric muscle contraction were carried
      out in the motion analysis Laboratory.
    

Detailed description: 
      A Pretest posttest control group design was used to. Two hundred normal subjects of both
      sexes were recruited.

      Subjects were randomly assigned into two groups of equal number.

        -  Cura Kensio-tapping group: consisted of 100 subjects (females and males) will receive
           kinesio taping from origin to insertion on the superficial muscles of Quadriceps femoris
           (vastus medialis (VM), vastus lateralis (VL), rectus femoris (RF).

        -  Placebo-Group: consisted of 100 subjects (females and males) will receive placebo
           kinesio taping across quadriceps.
    

Intervention name(s): Cura Kensio-tapping; placebo
Intervention type(s): Other; Other
Intervention description(s): Cura tapes, a cotton strip with an acrylic adhesive. allows for unidirectional elasticity up to 60% beyond its resting length.; placebo taping
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A Pretest posttest control group
Masking: None (Open Label)
Primary purpose: Health Services Research
Hospitalized Children and Adolescent Patients With Type 1 Diabetes During the COVID-19 Pandemic in Egypt
Condition: Type 1 Diabetes; Covid19
MeSH terms: COVID-19; Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Observational

Summary: 
      Although reports showed that children with well controlled diabetes do not appear to have
      increased risk of infection with SARS-CoV-2, however data are scarce regarding the extent to
      which clinical and demographic data of patient could modify the outcome and severity of the
      disease. Additionally, the link between covid-19 and diabetes remains controversial.
    

Detailed description: 
      Data from poorly controlled patients with type 1 diabetes remains controversial regarding
      whether diabetes itself could increases the susceptibility of infection with SARS-CoV-2 and
      subsequently impacts the outcomes in these patients , or the SARS-CoV-2 subsequently affects
      the risk of type 1 diabetes and increase in the prevalence of severe DKA.

      Poorly controlled diabetes and chronic hyperglycemia creates a state of low grade chronic
      inflammation, which may explain the underlying mechanism of increased susceptibility to
      infection and infer the outcome in patients with diabetes .

      Poorly controlled diabetes has been linked to multiple derangements of immune system
      including inhibition of lymphocyte proliferation in response to different stimuli, as well as
      impaired monocyte/macrophage function together with increased synthesis of pro-inflammatory
      cytokines and adhesion molecules that mediate tissue inflammation .

      Few data links the association between development of diabetic ketoacidosis in patients with
      COVID-19, where the infection could trigger higher stressful conditions, with the release of
      stress hormones leading to increased blood glucose levels and abnormal glucose variability .

      The extent to which clinical and demographic data of patients with type 1 diabetes modifies
      the outcome and severity of the disease seems entirely unclear and is the question of several
      researches.

      • Study Tools:

      All patients admitted to Pediatrics Hospital, Ain Shams University in the period between May
      to August 2020 will be subjected to:

      1- Detailed history 2. Thorough clinical examination: To assess the inclusion and exclusion
      criteria. A thorough clinical review to assess organ involvements and clinical and laboratory
      characteristics as well as the outcome measures in the studied cohort.

      3. Data collection: Demographic and data will be extracted from patients inpatient files and
      reports
    

Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        All diabetic patients admitted to Pediatrics Hospital, Ain Shams University in the period
        between May to August 2020.
      
Keywords: Type 1 Diabetes; Covid 19; Diabetic ketoacidosis
Ranolazine and Pulmonary Hypertension
Condition: Angina; Pulmonary Arterial Hypertension
MeSH terms: Pulmonary Arterial Hypertension; Familial Primary Pulmonary Hypertension; Hypertension; Angina Pectoris
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of the study is to determine if the medication, ranolazine (study drug), can help
      improve blood flow to your heart, increase your exercise capacity and improve your quality of
      life (QOL). For this study, you will be asked to perform several tests in order to determine
      if your heart function, exercise capacity, chest pain and QOL have improved after 3 months of
      treatment with ranolazine. Ranolazine is approved by the U.S. Food and Drug Administration
      (FDA) for the treatment of angina.
    

Detailed description: 
      This study is looking to enroll patients with pulmonary hypertension (PH). PH is abnormally
      high blood pressure in the arteries of the lungs. It makes the right side of the heart need
      to work harder than normal and is usually caused by a narrowing of the small arteries of the
      lung. This narrowing makes it harder for the right side of the heart to circulate the blood
      to the lungs. Over time, the right side of the heart may become enlarged and symptoms (such
      as angina [chest pain] shortness of breath, fatigue, edema) begin to appear.

      Ranolazine is a safe, well-tolerated, and FDA-approved medication for the treatment of
      chronic stable angina. Ranolazine may potentially improve blood flow to the right ventricle
      (RV), thereby relieving angina while simultaneously improving RV performance and
      contractility. This latter effect may increase stroke volume and cardiac output which could
      translate into benefits in exercise capacity and improved quality of life.

      The purpose of this single center, non-randomized, prospective pilot study is to investigate
      the effects of 3 months treatment with ranolazine on pulmonary artery hemodynamics, exercise
      capacity and quality of life in patients with PAH and symptoms of angina or angina
      equivalent.
    

Intervention name(s): Ranolazine
Intervention type(s): Drug
Intervention description(s): ranolazine 1000 mg PO BID for 3 months
Other intervention name(s): Ranexa
Intervention MeSH terms: Ranolazine
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Angina; Right Ventricular Ischemia; Pulmonary Arterial Hypertension; Pulmonary Hypertension