bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Obesity Surgery on Renal Function
Condition: Impaired Renal Function
MeSH terms: Renal Insufficiency; Obesity
Study type: Observational

Summary: 
      Increasing risk of impaired renal function as a result of obesity is well known. Early data
      has postulated that weight loss might improve kidney function, but the evidence is rather
      limited due to the difficulties in measuring glomerular filtration rate(GFR) after weight
      loss. Cystatin C, GFR measurement using Cockcroft-Gault (CCG) and Modification of Diet in
      Renal Disease (MDRD) equations, have all yield conflicting results after weight loss surgery.

      The study aim to assess:

        1. use of 51Cr-EDTA Clearance as the methodological gold standard in evaluating changes in
           renal function before and after weight loss surgery.

        2. the reliability of using MDRD, CCG and Cystatin C in measuring GFR after weight loss
           surgery

        3. the differences in alterations in renal function dependent on the surgical procedures(
           gastric bypass, gastric band, sleeve gastrectomy).

        4. the use of urine albumin/creatinine ratio in detecting alterations in microalbuminuria.
    

Detailed description: 
      This is a prospective study on obese human subjects undergoing bariatric surgery. Forty-five
      patients due to undergo gastric bypass (n=15), gastric banding (n=15), and gastric sleeve
      surgery (n=15) will be recruited.

      Subjects will be screened prior to entry into the study with full history, examination,
      routine bloods (FBC, U+E, liver function tests, and glucose).

        1. Blood samples and 24h urine specimens are taken at four time points: preoperatively as
           well 6 weeks, 6 and 12 months postoperatively.

        2. The following methods of GFR assessment will be executed the same time point:
           measurement of serum creatinine concentration, calculation of the abbreviated and
           extended MDRD formulae, CCG, creatinine clearance, serum Cystatin C concentration and
           the 51Chromium-EDTA clearance.

      Inclusion criteria

        1. Patients with a BMI of >35kg/m2 approved for obesity surgery based on the NICE criteria.

        2. Patients with a GFR <60 mL/min/1.73

      Exclusion criteria

      1. Allergy to chromium
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        1. Patients with a BMI of >35kg/m2 approved for obesity surgery based on the NICE
             criteria.

          2. Patients with a GFR <60 mL/min/1.73 m2
      
Keywords: obesity related glmerulopathy; 51 Cr-EDTA clearance; impaired renal function; gastric band; GFR measurement; gastric bypass; sleeve gastrectomy
Preoperative Cognitive Therapy for Improving Health Outcomes After TKA in High-risk Catastrophizing Subjects
Condition: Catastrophization
Study type: Interventional

Summary: 
      The investigators propose a randomized controlled trial to evaluate the effects of treatment
      intended to reduce pain catastrophizing among patients reporting high pain catastrophizing
      prior to total knee replacement(TKR), total hip replacement(THR), or shoulder surgery in an
      effort to thereby reduce the incidence of persistent post-surgical pain (PPP) and enhance
      physical function at 3-months post-surgery. Preemptive treatment aimed at a known predictor
      of PPP following total knee replacement is highly innovative and have potentially high impact
      for public health. Cognitive therapy is a well-tolerated modality among chronic pain patients
      with few if any side effects. Cognitive therapy (CT) represents an inexpensive method that
      could greatly reduce suffering and costly post-surgical pain management for high risk TKR
      patients.
    

Detailed description: 
      Aim 1 is to determine which CT protocol is most effective in reducing Pain Catastrophizing
      Scale (PCS) and Coping Strategies Questionnaire Catastrophizing Subscale (CSQ-CAT) scores in
      high-risk TKR candidates. CT will consist of four-to-eight weekly 1-hr individual cognitive
      therapy sessions prior to surgery.

      Aim 2 is to compare the most efficient treatment from Aim 1 with a control group to evaluate
      pain relief at 3 months.
    

Intervention name(s): Cognitive Therapy; Routine Care
Intervention type(s): Other; Other
Intervention description(s): CT will be used as a preemptive treatment in an effort to minimize the effects of catastrophic thinking.; Routine Care. No Cognitive Therapy Intervention
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: n=80 Subjects for Aim 1 and another n=80 Subjects for Aim 2
Masking: Single (Investigator)
Primary purpose: Prevention
Comparison Between the Lingually Based and the Buccally Based Triangular Flap Design in the Surgical Removal of Impacted Mandibular Third Molars
Condition: Tooth, Impacted
MeSH terms: Tooth, Impacted
Study type: Interventional

Summary: 
      The primary objective of this study was to compare between the lingually based triangular
      flap with the buccally based triangular flap in the surgical removal of impacted mandibular
      third molars.
    

Detailed description: 
      Many flap designs used for impacted third molar surgery do not place the mucoperosteal
      incision on sound bone, as they involve incisions that are placed on the extraction socket
      resulting in higher incidence of mucosal dehiscence, followed by secondary wound healing

      This study involved 20 patient with bilaterally mesially angulated impacted third molar
      (class II position B). One side was surgically removed using the lingually based triangular
      flap and the other side was surgically removed using the bucally based triangular flap
    

Intervention name(s): Lingually based triangular flap; Buccally based triangular flap
Intervention type(s): Procedure; Procedure
Intervention description(s): A lingually based triangular flap was used to remove the impacted third molar. An incision was made adjacent to the distal surface of the mandibular second molar and extended along the sulcus to the distobuccal corner of the mandibular second molar, an oblique vestibular incision was made and extended into the vestibular fornix of the mandible. Aligned with the mesiobuccal cusp of the second molar.
It was continued posterosuperior towards the anterior border of the mandibular ramus An incision will be made from the anterior border of the mandibular ramus to the distal surface of the mandibular second molar.; The impacted teeth was removed using a buccal based triangular flap. It will be extended along the sulcus to the distobuccal corner of the second molar . The incision was continuous, with a relieving vertical incision, oblique into the mandibular vestibular fornix, aligned with the mesiobuccal cusp of the second molar.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: this study involved 20 patient with bilaterally mesially angulated impacted third molar (class II position B). One side was surgically removed using the lingually based triangular flap and the other side was surgically removed using the bucally based triangular flap
Masking: Single (Participant)
Primary purpose: Treatment
A Phase III Study to Evaluate the Safety, Tolerance, and Efficacy of Early Treatment With Zidovudine (AZT) in Asymptomatic Infants With HIV Infection
Condition: HIV Infections
MeSH terms: Infections; Communicable Diseases; HIV Infections; Acquired Immunodeficiency Syndrome
Study type: Interventional
Phase: Phase 3

Summary: 
      Primary: To determine the efficacy of early treatment with zidovudine (AZT) in HIV-infected
      asymptomatic infants. To determine the safety and tolerance of AZT in this patient
      population.

      Secondary: To compare the virologic and immunologic parameters between the treatment groups.
      To determine the efficacy of AZT as an early treatment to prevent development of CD4+ cell
      depletion in HIV-infected asymptomatic infants.

      AZT is currently indicated for primary treatment in children with HIV-associated signs and
      symptoms and for those with significant immunodeficiency. This study will attempt to
      determine whether early treatment with AZT prevents the development of symptoms in
      HIV-infected infants who are asymptomatic.
    

Detailed description: 
      AZT is currently indicated for primary treatment in children with HIV-associated signs and
      symptoms and for those with significant immunodeficiency. This study will attempt to
      determine whether early treatment with AZT prevents the development of symptoms in
      HIV-infected infants who are asymptomatic.

      Patients are randomized to receive oral AZT (at age-adjusted doses) or placebo. Patients are
      evaluated at weeks 2 and 4 and every 4 weeks thereafter; those who reach a study endpoint
      will have their treatment unblinded to allow the clinician to determine which treatment
      regimen the patient should then receive. Patients who meet the criteria for changes to
      open-label AZT will be given the appropriate age-adjusted dose without unblinding the
      original randomization assignment. Patients who complete or discontinue treatment are
      followed every 6 months for up to 2 years.
    

Intervention name(s): Zidovudine
Intervention type(s): Drug
Intervention MeSH terms: Zidovudine
Primary purpose: Treatment
Keywords: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Zidovudine
Internet-delivered CBT for Functional Abdominal Pain in Adolescents - a Pilot
Condition: Functional Gastrointestinal Disorders; Abdominal Pain; Dyspepsia
MeSH terms: Gastrointestinal Diseases; Digestive System Diseases; Dyspepsia; Abdominal Pain
Study type: Interventional

Summary: 
      This pilot-study aims to evaluate the treatment effects and feasibility of an
      internet-delivered CBT-program adjusted for adolescents with functional abdominal pain and
      functional dyspepsia.
    

Detailed description: 
      Functional abdominal pain (FAP) and functional dyspepsia, are common in adolescents and
      associated with impaired quality of life. In adults with IBS, internet-delivered CBT leads to
      reduced symptoms and increased quality of life, but studies in children are lacking. This
      pilot-study aim to evaluate the treatment effects and feasibility of an internet-delivered
      CBT-program for adolescents with FAP and FD.

      Method: Pilot study with a pre-post-design and no control group. The internet-delivered
      CBT-program will last for 10 weeks and include weekly therapist support, consisting of online
      messages and telephone calls.
    

Intervention name(s): Internet-delivered CBT
Intervention type(s): Behavioral
Intervention description(s): The Internet-delivered exposure treatment is based on the well-established internet-delivered CBT-treatment for IBS in adults, adapted for adolescents with FAP/FD and their parents. Main component in the treatment is exposure for symptoms. The purpose of the treatment is to reduce fearful and anxious responses to symptoms and lessen avoidance of symptoms in the adolescents, and to teach the parents how parental behavior can influence symptoms in children as well as how to support exposure. Detailed behaviour analysis is made for each individual and instruction is given on how to gradually expose to symptoms to lessen fear for symptoms and widen the behavioral repertoire.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
AMG 529 First in Human Study
Condition: Cardiovascular
Study type: Interventional
Phase: Phase 1

Summary: 
      A study to assess the safety and tolerability of AMG 529 following single, ascending doses
      administered subcutaneously (SC) or intravenously (IV) in healthy adults.
    


Intervention name(s): AMG 529; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Ascending single doses of AMG 529 by subcutaneous (SC) or intravenous (IV) injection; Single doses of matching placebo by SC or IV injection
Allocation: Randomized
Intervention model: Sequential Assignment
Intervention model description: Within each dose cohort participants were randomized in a 3:1 ratio to receive either AMG 529 or placebo.
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Pilot Study of Robot-assisted Therapy for Post-stroke Forearm and Wrist Rehabilitation Training
Condition: Stroke
MeSH terms: Stroke
Study type: Interventional
Phase: Phase 1

Summary: 
      A pilot study to assess the effectiveness of CR2-Haptic and determine the feasibility of
      including robotic therapy into the daily rehabilitation program.
    

Detailed description: 
      The objective of this study is to clinically assess the effectiveness of CR2-Haptic and
      determine the feasibility of including robotic therapy into the daily rehabilitation program,
      and investigate the acceptance from patients and therapists. Total of 7 patients will be
      recruited in this study, all the patients will receive 1.5 hours of standard therapy together
      with 0.5 hour of robot therapy every day. The robot therapy will be a 30 mins long session
      for 3 to 5 days per week over a period of six weeks. The study will include forearm
      pronation-supination and wrist flexion-extension training.
    

Intervention name(s): Robot-assisted therapy for wrist and forearm; Standard rehabilitation therapy
Intervention type(s): Device; Other
Intervention description(s): Robot therapy by using a single degree reconfigurable robot to train for wrist and forearm rehabilitation training.; Standard therapy of stroke rehabilitation including speech, physical, occupational therapies and group activities
Other intervention name(s): CR2-Haptic Rehabilitation Robot
Intervention model: Single Group Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Stroke; Robot-assisted therapy; Rehabilitation
Comparing Safety and Immunogenicity of HEPLISAV-B® to Engerix-B® in Chronic Kidney Disease (CKD) Patients
Condition: Chronic Kidney Disease
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of the study is to demonstrate the safety and immunogenicity of a new
      investigational hepatitis B virus vaccine, HEPLISAV-B, in patients 18 to 75 years of age who
      have progressive loss of kidney function.
    


Intervention name(s): HEPLISAV-B; Engerix-B; Placebo
Intervention type(s): Biological; Biological; Other
Intervention description(s): Intramuscular (IM) injections of HEPLISAV-B at Weeks 0, 4, and 24; Intramuscular (IM) injections at Weeks 0, 4, 8, and 24; Placebo(saline) intramuscular (IM) injection at Week 8
Other intervention name(s): Hepatitis B vaccine (recombinant), adjuvanted; Hepatitis B vaccine (recombinant); Saline
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Keywords: chronic kidney disease; kidney failure; kidney failure,chronic; chronic kidney failure; hepatitis B virus (HBV) vaccine; hepatitis B vaccine; hepatitis B; hepatitis; HBV; prevention and control; dialysis
Breathing Exercise in Pregnancy-induced Hypertension
Condition: Pregnancy Induced Hypertension
MeSH terms: Respiratory Aspiration; Hypertension, Pregnancy-Induced; Hypertension
Study type: Interventional

Summary: 
      To determine the effects of Breathing control vs Alternate nostril breathing on maternal
      cardiovascular parameters in pregnancy and to determine the effect of breathing control vs
      Alternate nostril breathing on Fetal Heart rate. Many evidence-based studies show breathing
      exercises have beneficial and useful effects on the hypertensive population and also have
      positive effects on pregnancy-induced hypertension.
    

Detailed description: 
      Many breathing interventions are used for pregnancy-induced hypertension but the comparison
      is limited between two breathing techniques. In this study, a comparison will be carried out
      between evidence-based breathing techniques including breathing control and alternate nostril
      breathing to see which of these two exercises gives the best effects on females with
      pregnancy-induced hypertension.
    

Intervention name(s): Group A; Group B
Intervention type(s): Other; Other
Intervention description(s): Close your eyes and exhale through your left nostril fully and slowly, once you have exhaled completely, release your right nostril and place your ring finger on the left nostril.
Breathe in deeply and slowly from the right side. Make sure your breath is smooth and continuous. Aerobics exercises (Walking): 3-5 days per week at moderate intensity, of approximately 30 minutes.
Start slowly and gradually increase your walking pace over 3 minutes until the activity feels moderate (slightly increased breathing, but should still be able to talk.
Walk at a moderate pace for about 10 minutes the first then gradually increase time with RPE(8-9).; The position of the woman should be relaxed and comfortable e.g., crock lying, sitting, standing position. Place one hand on chest and other on stomach and close eyes to relax and focus on breathing. Slowly breathe in through nose with your closed mouth.Breathe out through your nose and try to use as small effort as possible and make your breaths slow, relaxed and smooth.
Aerobics exercises (Walking): 3-5 days per week at moderate intensity, of approximately 30 minutes.
Start slowly and gradually increase your walking pace over 3 minutes until the activity feels moderate (slightly increased breathing, but should still be able to talk.
Walk at a moderate pace for about 10 minutes the first then gradually increase time with RPE(8-9).
Other intervention name(s): Alternate nostril breathing
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Breathing control; Alternate nostril breathing; Maternal cardiovascular parameters; Fetal Heart rate
Clinical Study on the Effect of Probiotic Compound Powder on the Immunity Improvement of Preschool Children
Condition: Immunity
Study type: Interventional

Summary: 
      This is a randomized controlled trial, to evaluate the effect of WONDERLAB Probiotic Compound
      Powder on improving immunity of preschool children
    

Detailed description: 
      The community hospital will recruit 140 preschool children, aged 5 to 6 years old, according
      to the inclusion and exclusion criteria, and randomly assigned them to 2 groups. 70 subjects
      in the placebo group and 70 in the experimental product group.

      First entered a one-week washout period, and then entered a 25-week clinical intervention,
      and finally ensured that 100 volunteers completed the whole study, and the withdrawal rate
      was about 28%.
    

Intervention name(s): Wonderlab Kids instant probiotics; Instant probiotic placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): During study intervention, subjects are required to take the randomly assigned product based on the randomization list.
Taking assigned product directly or mix it with milk/water/other liquids below 37 ℃, take it half an hour after meal.1 bottle a day. Lasting for 24 weeks intervention period.; Subjects are required to take the randomly assigned Instant probiotic placebo based on the randomization list.
Taking assigned product directly or mix it with milk/water/other liquids below 37 ℃, half an hour after meal.
1 bottle a day. Lasting for 24 weeks intervention period.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The community hospital will recruit 140 preschool children, aged 5 to 6 years old, according to the inclusion and exclusion criteria, and randomly assigned them to 2 groups. 70 subjects in the placebo group and 70 in the experimental product group.
First entered a one-week washout period, and then entered a 25-week clinical intervention, and finally ensured that 100 volunteers completed the whole study, and the withdrawal rate was about 28%.
Masking: Single (Investigator)
Primary purpose: Other
Keywords: Rotavirus; Upper respiratory tract infection; Bristol scoring method
Biosignals by Wearable Devices in Hypothyroidism
Condition: Hypothyroidism
MeSH terms: Hypothyroidism
Study type: Observational

Summary: 
      This is a prospective observational cohort study. Monitoring continuous biosignals using
      wearable devices in thyroid cancer patients who are planned to withdraw their levothyroxine
      for radioactive iodine therapy. Through this, bio signals can be collected in the subjects in
      hypothyroid status. Physical activity, heart rate, and sleep data will be collected during
      the study period.
    

Detailed description: 
      A prospective observational cohort study including two groups.

      Hypothyroid group:

      Patients with differentiated thyroid carcinoma underwent total thyroidectomy Patients who are
      planned to withdraw their levothyroxine for radioactive iodine therapy Biosignals will be
      monitored continuously using Fitbit devices

      Control group:

      Patients with differentiated thyroid carcinoma underwent total thyroidectomy Patients who are
      planned to get rhTSH (not to withdraw their levothyroxine) for radioactive iodine therapy
      Biosignals will be monitored continuously using Fitbit devices Thyroid hormone levels and
      continuously collected bio signals including activity, heart rate, and sleep data will be
      obtained during study period.

      Association between thyroid status and bio signals will be investigated.
    

Intervention name(s): levothyroxine withdrawal
Intervention type(s): Other
Intervention description(s): All participants of this study are decided to get radioactive iodine therapy using levothyroxine withdrawal or human recombinant TSH injection prior to the study enrollment. That decision is independent with this study protocol. This study just collect continuous bio signals using wearable devices in the patients undergoing two different preparation methods for radioactive iodine therapy. That is why this study is an observational cohort study.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with differentiated thyroid carcinoma underwent total thyroidectomy Patients who
        are planned to get radioactive iodine therapy