bioihbjkbjnl/mcl2 huggingface dataset:
Effect of a Polyphenol Rich Diet on Vascular and Platelet Function
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      Previous work has shown that increasing fruit and vegetable intake in patients with high
      blood pressure improves cardiovascular function. Research indicates that this may be partly
      owing to compounds called polyphenols, which are found in abundance in fruits and vegetables
      and other foods such as wine, tea and dark chocolate. The investigators now wish to test if
      consuming fruits and vegetables (including berries which are very rich in polyphenols), as
      well as dark chocolate, has further benefits for cardiovascular function. A total of 110
      subjects with high blood pressure will be recruited and asked to follow a low polyphenol diet
      (2 portions of fruit and vegetables daily and no berries or dark chocolate) for four weeks (a
      washout period). They will then be randomised to continue this diet or to consume 6 portions
      of fruits and vegetables (to include 1 portion berries) and 1 portion of dark chocolate daily
      for 8 weeks. The fruit, vegetables and dark chocolate will be provided free of charge and
      delivered to the homes of the participants who are randomised to the high fruit and vegetable
      arm of the study.

      Assessment of microvascular and platelet function will be undertaken before and after
      consuming this diet. Improvements in these tests of cardiovascular function have previously
      been linked to reduced risks of heart disease in people with high blood pressure. This study
      will provide evidence as to whether or not a polyphenol rich diet can reduce the risk of
      developing heart disease.
    


Intervention name(s): Two portions of fruit and vegetables per day (excluding berries and dark chocolate); Six portions of fruit and vegetables per day (one of which must be berries) and 50g dark chocolate.
Intervention type(s): Other; Other
Intervention description(s): Two portions of fruit and vegetables per day (excluding berries and dark chocolate); Six portions of fruit and vegetables per day (one of which must be berries) and 50g dark chocolate.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Hypertension; Microvascular function
Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD)
Condition: Obsessive-Compulsive Disorder
MeSH terms: Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This pilot study is proposed to determine the acceptability, feasibility and potential
      efficacy of ketamine, a medication that modulates glutamate in the brain, as a rapid
      treatment for obsessive-compulsive disorder (OCD) symptoms in adolescents and young adults
      with OCD. This study will recruit 6 youth (ages 14-22) who are diagnosed with clinically
      significant OCD and have failed at least one adequate trial of a Serotonin Reuptake Inhibitor
      (SRI) medication and a course of Cognitive-Behavioral Therapy (CBT) (unless unable to access
      or tolerate) for OCD in the past. Participants will receive a single infusion of intravenous
      ketamine and be assessed at regular intervals post-infusion for up to 14 days. At the end of
      the 14-day treatment phase, all participants will be offered three months of open treatment
      for OCD with medication and/or CBT.
    

Detailed description: 
      See Brief Summary for description.
    

Intervention name(s): Ketamine
Intervention type(s): Drug
Intervention description(s): Single infusion of IV Ketamine, 0.5mg/kg
Other intervention name(s): Ketalar
Intervention MeSH terms: Ketamine
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Obsessive Compulsive Disorder; Ketamine; Glutamate; OCD treatment; OCD medication
Bioavailability of BIBR 1048 MS With and Without Pantoprazole Under Influence of Food in Healthy Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      To assess the extent of absorption of 150 mg of BIBR 1048 administered as capsule formulation
      with and without coadministration of 40 mg Pantoprazole and to assess the effect of food on
      rate and extent of absorption.
    


Intervention name(s): BIBR 1048 MS; Pantoprazole
Intervention type(s): Drug; Drug
Intervention MeSH terms: Pantoprazole; Dabigatran
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Dietary Intake and Vitamin D Level in Adult Women
Condition: Deficiency of Vitamin D3
Study type: Observational

Summary: 
      Vitamin D deficiency is most diagnosed among women living in the Kingdom of Saudi Arabia.
      Many factors have been attributed to the incidence of vitamin D deficiency. Saudi women are
      thought to be at greater risk for vitamin D deficiency because of their darker skin type and
      the likelihood of reduced ultraviolet exposure . The present study entitled, "Dietary Intake
      and Vitamin D Level in adult Women," was formulated as there is paucity of data on the
      etiologic importance of dietary intake in Vitamin D level on blood on women. The major
      objective of the proposed study is to assess the effect of dietary intake of nutrients and
      level of vitamin D in women .
    

Detailed description: 
      For this study, the investigators enrolled 168 women 35-55 years old to evaluate Vitamin D
      status and to determined whether status was correlated with Vitamin D deficiency.

      All women completed a self-administered questionnaire about personal socio-demographic
      characteristics; They all had anthropometric measurements of body mass index and waist
      circumference. A 24-hour dietary recall was administered to all women.

      The proximate analysis of 25 types of food was conducted according to the American
      Association of Organic Chemists (AOAC) methods. The following parameters were measured: serum
      calcium. Vitamin D, levels of parathyroid hormone.
    

Intervention name(s): Vitamin D status
Intervention type(s): Other
Intervention description(s): There is no intervention in this study
Intervention MeSH terms: Vitamin D
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Pre and post-menopausal women 35-55 years of age who were able to provide a 24 hour dietary
        record.
      
Keywords: Vitamin D; Calcium; Phytic Acid; body weight
Evaluation of Bilirubin Estimates in Newborns From Smartphone Digital Images in a Nepali Population
Condition: Jaundice, Neonatal
MeSH terms: Jaundice, Neonatal; Jaundice
Study type: Interventional

Summary: 
      This cross-sectional study evaluates the accuracy of a novel smartphone application that
      estimates bilirubin levels in newborns at Dhulikhel Hospital, Kathmandu Nepal.
    

Detailed description: 
      This cross-sectional study evaluates the accuracy of a novel smartphone application that
      estimates bilirubin levels in 200 newborns at Dhulikhel Hospital, Kathmandu Nepal. The
      Picterus Calibration Card was placed on the chest of the newborn with the hole in the card
      placed over the infant's sternum. A validated smartphone with Picterus JP was used to collect
      digital images.
    

Intervention name(s): Picterus Jaundice Pro
Intervention type(s): Device
Intervention description(s): Use Picterus Jaundice Pro, a smartphone app that is used to take photo of the newborns skin, where the Picterus calibration card is place
Other intervention name(s): Picterus JP
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Screening
The Efficacy and Safety of Sphenopalatine Ganglion Pulsed Radiofrequency Treatment for Cluster Headache
Condition: Cluster Headache
MeSH terms: Cluster Headache; Headache
Study type: Interventional

Summary: 
      The investigators aim to investigate the effectiveness and safety of sphenopalatine ganglion
      pulsed radiofrequency on cluster headache.
    

Detailed description: 
      The investigators aim to investigate whether the sphenopalatine ganglion pulsed
      radiofrequency treatment is better than traditional sphenopalatine ganglion nerve block
      technology and provides medical evidence for the clinical application and promotion of
      sphenopalatine ganglion pulsed radiofrequency treatment to provide a minimally invasive,
      safe, and effective treatment for patients with cluster headache who do not respond to drug
      treatment.
    

Intervention name(s): Pulsed Radiofrequency treatment; Nerve Block treatment
Intervention type(s): Procedure; Procedure
Intervention description(s): The pulse treatment generator (PMF-21-100-5, Baylis Medical Inc., Montreal, Canada) with a length of 10 cm, 21-gauge, and an active tip length of 5 mm is inserted vertically into the puncture point. The pulse treatment generator is set to the pulsed radiofrequency automatic mode, with a temperature of 42 °C, pulse frequency of 2 Hz, pulse width of 20 ms, and treatment duration of 360s.; A mixture of 40 mg Triamcinolone + 2 ml of 1% Bupivacaine + 2 ml of 2% mepivacaine + 1:100000 epinephrine is injected for nerve block treatment using a puncture needle.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Cluster Headache, pulsed radiofrequency
A Study to Evaluate the Pharmacokinetic Drug-drug Interactions Between VX-548, Midazolam, and Digoxin
Condition: Pain
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the pharmacokinetics of midazolam and digoxin in the
      absence and presence of VX-548.
    

Detailed description: 
      This clinical trial information was submitted voluntarily under the applicable law and,
      therefore, certain submission deadlines may not apply. (That is, clinical trial information
      for this applicable clinical trial was submitted under section 402(j)(4)(A) of the Public
      Health Service Act and 42 CFR 11.60 and is not subject to the deadlines established by
      sections 402(j)(2) and (3) of the Public Health Service Act or 42 CFR 11.24 and 11.44.).
    

Intervention name(s): VX-548; Midazolam; Digoxin
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Tablets for oral administration.; Syrup for oral administration.; Tablets for oral administration.
Intervention MeSH terms: Digoxin; Midazolam
Intervention model: Sequential Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Exclusive Breastfeeding Improves Puerperal Glucose Metabolism in Pregnant Women With Gestational Diabetes Mellitus and Links to Lipids Composition
Condition: Gestational Diabetes; Breast Feeding; Lipid Metabolism Disorders
MeSH terms: Diabetes, Gestational; Metabolic Diseases; Lipid Metabolism Disorders
Study type: Observational

Summary: 
      Breastfeeding could effectively be associated with a lower risk of future type 2 diabetes
      (T2D) in women with gestational diabetes mellitus (GDM), but the short-term protective impact
      of puerperal breastfeeding on maternal metabolic recovery of GDM women remains unascertained.
      The investigators recruited GDM participants at 6-9 weeks postpartum and retrieved clinical
      diagnoses of GDM from electronic medical records. Feeding patterns were collected via phone
      calls. Glucose metabolism parameters and lipid profiling were performed on fasting plasma
      samples collected from patients 6-9 weeks postpartum (20 breastfeeding cases vs. 15 formula
      feeding cases).
    


Intervention name(s): observe
Intervention type(s): Other
Intervention description(s): no intervention
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        women (aged 18-35 years) who delivered live-born infants equal to or greater than 37 weeks
        of gestation at the Women's Hospital of Nanjing Medical University (Nanjing, China) and
        were not using medications affecting glucose tolerance, lipid regulation and not planning
        another pregnancy within the next 2 years were enrolled. All the participants received 75g
        OGTT at 24-28 weeks of gestation and were diagnosed with GDM based on the IADPSG criteria
        (International Association of Diabetes and Pregnancy Study Groups Consensus Panel et al.).
        At 6-8 weeks postpartum, all the participants were administered regularly for a post-natal
        health check-up to classify the body and genitals basically restored status. Fasting plasma
        samples were collected to measure plasma glucose, and insulin, and reclassify glucose
        metabolic status. Frequency and amount of breastmilk feeding and formula feeding for each
        woman were evaluated by trained research staff via telephone calls.
Brain as a Therapeutic and Research Target in Trigeminal Neuropathic Pain
Condition: Trigeminal Neuropathic Pain
MeSH terms: Neuralgia
Study type: Interventional

Summary: 
      The main goal of this study to integrate techniques producing images of the brain (also
      called neuroimaging techniques) with non-invasive brain stimulation to investigate factors
      that may be associated with chronic pain in patients with Trigeminal Neuropathic Pain (TNP).
    

Detailed description: 
      Trigeminal neuropathic pain (TNP) disorders, such as classical trigeminal and post-surgical
      neuralgia, are debilitating chronic conditions with pain that is either spontaneous or that
      can be intensely evoked by light touch to the facial skin. Although neuroimaging techniques
      have provided insights into some brain mechanisms of experimental trigeminal pain in humans
      (DaSilva et al., 2002; Borsook et al., 2003), it is not well understood how structural and
      molecular mechanisms are affected during the course of TNP, and how they can be safely
      modulated for therapeutic and research purposes. Understanding these processes is crucial to
      determine the structures engaged in the development and persistence of TNP.

      We will test the hypothesis that chronicity of TNP is sustained by changes at cellular and
      molecular levels in neural circuits associated with pain perception and modulation, rather
      than by the initial peripheral etiology, and that this dysfunction can be safely targeted and
      modulated as a therapeutic approach by transcranial direct current stimulation (tDCS). To
      achieve this goal we will use a neuroimaging technique, PET, employing a mathematical model
      that permits the quantification of opioid receptor availability in vivo.
    

Intervention name(s): PET Scans; transcranial direct current stimulation (tDCS); MRI; sham tDCS (prior to real tDCS)
Intervention type(s): Procedure; Procedure; Procedure; Other
Intervention description(s): Two 90 minute scans whose maximum radiological dose is 15 mCi [11 C] carfentanil, a selective and specific mu-opioid receptor radioligand. The first one provided baseline data, and the second occurred with the sequence of sham tDCS and tDCS as described in each arm description.; In active tDCS, a 2 milli-amp transcranial direct current stimulation is for 20 minutes.; No radiotracer is used; 3 tesla scanner; all participants have MRI prior to PET scans.; For sham tDCS, current is applied only for 30 seconds, as sensations arising from tDCS treatment occur only at the beginning of application; however the equipment will be on the participant for 20 minutes to match that of the active tDCS application.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects.
Condition: Hepatic Flow Changes
Study type: Interventional

Summary: 
      Hepatic artery and portal flows are both regulated to assume the whole hepatic blood flow.
      Each counts for respectively 25% and 75%. That so-called "buffer response" assumes that when
      portal flow increases, hepatic artery flow decreases. During fluid challenge in intensive
      care unit, fluid challenge is often administered to improve hepatic perfusion. That
      observation is not demonstrated. The aim of the study is to test buffer response and portal
      flow during fluid challenge.
    

Detailed description: 
      Prospective monocentric study at Amiens Hospital University. 20 volunteers subjects will be
      include after providing informed consent. Fluid challenge will be performed with 500 ml of
      intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI.
    

Intervention name(s): MRI (magnetic resonance imaging)
Intervention type(s): Device
Intervention description(s): Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI.
Other intervention name(s): 500 ml of intra venous NaCl (0.9%).
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Short Term Group Therapy for Anxiety Disorder
Condition: Anxiety Disorder
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      Assessing Anxiety in patient suffering from anxiety disorders (NOT OCD or PTSD)before and
      after group therapy
    


Intervention name(s): Group therapy
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Relationship Between Sarcopenia and Cardiovascular Disease in Chronic Kidney Disease and the Risk Involved.
Condition: Sarcopenia; CKD; Cardiovascular Diseases
MeSH terms: Sarcopenia; Kidney Diseases; Renal Insufficiency, Chronic; Cardiovascular Diseases
Study type: Observational

Summary: 
      This study explores the risk factors for sarcopenia in patients with chronic kidney disease
      and the effects of sarcopenia on cardiovascular disease. Treatment of sarcopenia and
      cardiovascular complications provides a basis for improving the quality of life and survival
      of patients with chronic kidney disease.
    

Detailed description: 
      Sarcopeniais a syndrome characterized by the loss of skeletal muscle mass, muscle strength,
      and muscle dysfunction. The high incidence of sarcopenia in patients with chronic kidney
      disease (CKD) is strongly associated with poor quality of life, cardiovascular events, and
      increased all-cause mortality. At present, the cause of sarcopenia in patients with CKD is
      still unclear, and factors such as inflammation, malnutrition, and hormone metabolism
      disorders may affect the occurrence and development of sarcopenia. This topic explores the
      risk factors of sarcopenia in patients with chronic kidney disease and the correlation
      between sarcopenia and the risk of cardiovascular disease, and provides a basis for the
      prevention and treatment of sarcopenia and cardiovascular complications, with a view to
      improving the prognosis of CKD patients.
    

Observational model: Cohort
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        patients with chronic kidney disease
The Effect of Semaglutide on Pituitary Function
Condition: Healthy
MeSH terms: Pituitary Diseases
Study type: Interventional
Phase: Phase 4

Summary: 
      The primary aim of the study is to describe the effect of a single oral dose of semaglutide 7
      mg on growth hormone secretion.
    

Detailed description: 
      The randomized blinded placebo-controlled clinical trial is conducted on 10 healthy
      volunteers.

      5 study subjects receive once 7 mg of oral semaglutide and once placebo. 5 study subjects
      receive once 14 mg of oral semaglutide and once placebo. The study group and order of
      administration of study medication are decided on randomization. The placebo and oral
      semaglutide are administered at least 4 weeks apart.

      Blood samples are taken before and during 4 hours after the study medication administration
      (at 60, 90, 120, 150, 180, and 240 minutes after study medication administration).

      The primary endpoint is the peak value of growth hormone measured during the 4 hours after
      study medication administration.
    

Intervention name(s): Semaglutide 7 MG Oral Tablet; Placebo; Semaglutide 14 MG Oral Tablet
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Semaglutide 7 mg oral tablet taken after an overnight fast with up to 120 ml of water.; Placebo tablet is taken after an overnight fast with up to120 ml of water.; Semaglutide 14 mg oral tablet taken after an overnight fast with up to 120 ml water.
Other intervention name(s): Rybelsus 7 mg; Rybelsus 14 mg
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Blinded Randomised Single-group Crossover
Masking: Double (Participant, Care Provider)
Primary purpose: Diagnostic
Combination Therapy of Hydroxyurea With L-Carnitine and Magnesium Chloride in Thalassemia Intermedia
Condition: β-Thalassemia Intermedia
MeSH terms: Thalassemia; beta-Thalassemia
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is determination of the efficacy of combination of hydroxyurea with
      L-carnitine or magnesium in improving hematologic parameters and cardiac status in patients
      with β-thalassemia intermedia in comparison with hydroxyurea alone .
    


Intervention name(s): hydroxyurea; L-carnitine and hydroxyurea; hydroxyurea and magnesium chloride; hydroxyurea,L-carnitine and magnesium chloride
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Hydroxyurea (500 mg capsules) was administered in a single dose at a mean of 10/mg/kg/day (range8-12mg/kg/day).; Hydroxyurea (500 mg capsules) was administered in a single dose at a mean of 10/mg/kg/day (range8-12mg/kg/day). L-carnitine (Minoo, Iran, 250 mg tablets) was administered in divided doses (50mg/kg/day).; Hydroxyurea (500 mg capsules) was administered in a single dose at a mean of 10/mg/kg/day (range8-12mg/kg/day). Magnesium chloride powder ( tabib tajhiz nik, Iran) was formulated into suspension; each ml containing 1meq magnesium chloride. It was administered in divided doses at 0.6meq/kg/day.; Hydroxyurea (500 mg capsules) was administered in a single dose at a mean of 10/mg/kg/day (range8-12mg/kg/day). L-carnitine (Minoo, Iran, 250 mg tablets) was administered in divided doses (50mg/kg/day). Magnesium chloride powder ( tabib tajhiz nik, Iran) was formulated into suspension; each ml containing 1meq magnesium chloride. It was administered in divided doses at 0.6meq/kg/day
Intervention MeSH terms: Hydroxyurea
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: Hydroxyurea; magnesium chloride; L-carnitine; β-thalassemia intermedia