Omega-3, Nigella Sativa, Indian Costus, Quinine, Anise Seed, Deglycyrrhizinated Licorice, Artemisinin, Febrifugine on Immunity of Patients With (COVID-19)
Condition: Covid19; Immunodeficiency
MeSH terms: COVID-19
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      The first version of this preprint article is registered on the 4th of May 2020 under the
      digital object identifier of:10.31219/osf.io/u56fc.

      COVID-19 infections virus spread worldwide and impact many countries with sever economical
      sequences. The effective antiviral medication or vaccination for the virus is unavailable
      until the present date and it takes months or years to discover the effective treatment or
      test the efficacy of the discovered treatment.

      Based on these facts, the human immune system against the virus may have an effective role to
      regulate the infection and reduce the mortality rate among the infected patients. This
      proposed research article aims to explore the available medication/ natural supplementation
      to boost the immunity system of the patients against COVID-19 infections and reduce the
      mortality rate among infected patients. Methods: a proposed clinical trial will be carried
      out to investigate the effect of the different treatment modalities on the human immune
      system against COVID-19 infection.
    

Detailed description: 
      Natural supplementations have many reported effects on the human health ranged from immunity
      boosting to effective antiviral effect. Omeg-3 as an example affect the human health by many
      mechanisms e.g. Anti-oxidant, immunity boosting agent. Moreover, Omega-3 exerts an antiviral
      effect on Flu virus by inhibiting influenza virus replication 1. On the other hand, black
      seed supplementation exerts a chelation effect on sickle cell anemia patients and inhibits
      Human Heme Metabolism 2. Moreover, black seed exerts an antiviral effect on the replication
      of old coronavirus and the expression of (TRP-genes) family 3. In addition, Omega-3 regulates
      the human immunity against bacterial and viral infections 4. During the past years, many
      natural sources exerts an antimalarial effect with perfect reported results 5.
    

Intervention name(s): Omega 3/Nigella Sativa Oil; Omega 3/Nigella Sativa Oil/Indian Costus; Omega 3/Nigella Sativa Oil/Quinine pills; Omega 3/Nigella Sativa Oil/Anise seed capsule; Omega 3/Nigella Sativa Oil/Deglycyrrhizinated Licorice; Active Comparator
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA)
Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone; Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA)
Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone
Indian Costus supplements; Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA)
Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone
Quinine supplementation (1g Quinine); Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA)
Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone
Anise seed supplementation (450mg anise seed); Omega-3 supplementation 1000mg contains (300-400mg EPA & 200-300mg DHA)
Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone
Deglycyrrhizinated Licorice 800 mg; Standard protocol care of COVID-19 infection
Intervention MeSH terms: Quinine
Allocation: Randomized
Intervention model: Sequential Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: COVID-19; omega3; thymoquinone