bioihbjkbjnl/mcl2 huggingface dataset:
Effect of Bridge Exercise Performed at Different Knee Angles
Condition: Healthy
Study type: Interventional

Summary: 
      Stabilization exercises help increase strength, stability, balance, gait, and endurance
      through effective abdominal training. Bridge exercise, which is one of the closed kinetic
      exercises, is one of the most used spinal stabilization exercises. Although that exercise
      affects on the trunk muscles, it has been stated that it is related to all muscles of the
      lower extremity.There are some studies, which are examining the activation of the gluteus
      maximus, quadriceps, rectus abdominus, iliocostalis lumborum, iliocostalis thoracis, and
      gastrocnemius muscles while exercising the bridge. Although there are some studies
      investigating the activation of muscles at different knee angles, there is no study in the
      literature examining the effect of bridge exercise performed at different knee angles on the
      strength and endurance of lower extremity and trunk muscles. For these reasons, this study
      aimed to examine the effect of bridging exercises performed at different knee angles on
      muscle strength and endurance in healthy subjects.
    

Detailed description: 
      Participants included in the study will randomly divide into 3 different groups by using
      simple sealed envelope randomization method. Participants in the first group will perform
      exercise at knee angle was 45⁰ flexion, the participants in the second group will perform to
      exercise at knee angle 60⁰ flexion and the participants in the third group will perform
      exercise knee angle at 90⁰ flexion. All participants will include in a bridging exercise
      program by a blind researcher at predetermined knee angles (45⁰, 60⁰ 90⁰), 3 sets of 15
      repetitions per day, 3 days a week for 6 weeks. Evaluations will be done by a blinded
      researcher 1 week before starting the 6-week exercise program and 1 week after they finished
      the program. All evaluations will be made by the same physiotherapist by meeting with
      participants face to face. Inclusion in the research will be on a voluntary basis. As outcome
      measures, muscle strength assessment and core Endurance Assessment will be evaluated.
    

Intervention name(s): Exercise
Intervention type(s): Other
Intervention description(s): Both groups will perform bridge exercise
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Healthy individuals; Bridge exercise; muscle strenght; core endurance
Preoperative Inflammatory Status and Postoperative Acute Kidney Injury
Condition: Postoperative Acute Kidney Injury
MeSH terms: Acute Kidney Injury; Wounds and Injuries
Study type: Observational

Summary: 
      Acute kidney injury (AKI) is a common complication during the early postoperative period
      after noncardiac surgery. Patients with AKI are at an increased risk of developing chronic
      kidney disease, prolonging hospitalization, and experiencing higher rates of morbidity and
      mortality. Identifying preoperative risk factors for postoperative AKI can significantly
      contribute to the development of preventive strategies and improved perioperative care in
      this vulnerable patient population.

      The goal of this retrospective study is to investigate the predictive value of preoperative
      inflammatory status, as measured by complete blood count-derived inflammatory markers, such
      as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR),
      monocyte-to-lymphocyte ratio (MLR), derived neutrophil-to-lymphocyte ratio (dNLR),
      neutrophil-to-lymphocyte*platelet ratio (NLPR), systemic immune-inflammatory index (SII),
      systemic inflammatory response index (SIRI), and aggregate index of systemic inflammation
      (AISI), on postoperative AKI in elderly patients undergoing non-cardiac surgery.
    


Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Elderly patients (aged ≥ 65 years) who underwent a non-cardiac surgery at Tongji Hospital
        between July 2018 and December 2021 were included in our study.
Study to Assess the Efficacy and Safety of SpotOn Specs™ for the Treatment of Chronic Dizziness
Condition: Chronic Dizziness
MeSH terms: Vertigo; Dizziness
Study type: Interventional

Summary: 
      The diagnosis and management of acute vertigo and dizziness is most of the time an easy task
      for the general practitioner. However, following an acute vestibular disorder and very often
      with no any overt cause, a considerable number of patients complain on chronic dizziness and
      subjective disturbance of balance despite normal clinical and laboratory tests. Patients
      describe that perceptual visual stimulus provoke or aggravate their symptoms that are
      frequently accompanied by anxiety. These cases have been described in the medical literature
      as Phobic Postural Vertigo, Visual Vertigo, Chronic Subjective Dizziness and Motion and Space
      Discomfort (2,3,4,5). Treatment of these conditions includes physical therapy (similar to
      vestibular rehabilitation exercises) and anti-anxiety or anti-depressant agents such as
      benzodiazepines and SSRI, however, the effectiveness of these approaches is debatable.

      Because visual stimuli play a crucial role in space orientation and motion perception, it is
      reasonable to hypothesize that certain visual stabilizing signals applied on the peripheral
      visual field (that is involved mainly in the perception of motion) could be of help in
      patients suffering from dizziness. This is the rationale of a new technology (SMB- Senso
      Mental Balance Technology) developed to alleviate the feelings of dizziness.

      Trial is conducted in Meir Medical Center, Israel. Recruitment only in Israel!
    


Intervention name(s): SpotOn's corrective elements for dizziness; Placebo
Intervention type(s): Device; Device
Intervention description(s): Eyeglasses with dizziness correction elements (real SpotOn eyeglasses) or eyeglasses with placebo (sham eyeglasses) elements will be worn during the whole four weeks study period.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Phobic Postural Vertigo; Visual Vertigo; Chronic Subjective Dizziness; Motion and Space Discomfort; SpotOn
The Therapeutic Effects of Topiramate and Metformin on Second Generation Antipsychotics-induced Obesity
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional

Summary: 
      The primary aim of the study is to investigate the efficacy of metformin and topiramate on
      second-generation antipsychotic-induced obesity. The secondary domain we look at is the
      adverse effects of both drugs. The investigators hypothesize that metformin and topiramate
      are effective in treating obesity induced by second-generation antipsychotics.
    


Intervention name(s): metformin, topiramate
Intervention type(s): Drug
Intervention description(s): metformin 250 mg/d is gradually increased to 1000 mg/d over four weeks, and topiramate 50 mg/d is gradually increased to 200 mg/d over four weeks
Intervention MeSH terms: Metformin; Topiramate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: metformin; topiramate; obesity; metabolic syndrome
MeFirst: A Tailored Intervention to HPV Vaccine Decision Making
Condition: Human Papillomavirus-Related Carcinoma
Study type: Interventional

Summary: 
      This study will test whether a tailored, online educational intervention increases HPV
      vaccine uptake and intent among female college students.
    

Detailed description: 
      MeFirst is the first web-based, online, educational tool designed to promote Human
      Papillomavirus (HPV) vaccine awareness and understanding in an effort to improve HPV vaccine
      intent and uptake among female university students. HPV is the most common sexually
      transmitted infection and causes genital warts and cancer. The HPV vaccine has been
      recommended for girls ages 11-26 since 2006, yet vaccination rates remain low. Tailored
      online interventions may be more effective tools to promote behavior change among college
      students than traditional static interventions. The proposed study is a randomized controlled
      trial testing the efficacy of the MeFirst tool vs. standard static educational material on
      increasing HPV vaccination intent and uptake among female university students aged 18-26.
    

Intervention name(s): MeFirst Tailored Intervention
Intervention type(s): Behavioral
Intervention description(s): Participants will be lead through MeFirst, an interactive web-based tool that is tailored to their responses during the survey. This tool provides information regarding HPV Vaccination.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Health Services Research
Keywords: tailored intervention; college aged students; HPV
Optimizing Ovarian Stimulation for IVF and ICSI
Condition: Efficiency in Terms of Mature Oocyte Yield
Study type: Interventional

Summary: 
      Monitoring ovarian stimulation for in vitro fertilization (IVF) and intracytoplasmatic sperm
      injection (ICSI) can be simplified by reducing the procedure to measuring follicles by
      ultrasound. Proponents of a simplified procedure claim that the procedure can be reduced to
      simple monitoring by ultrasound while maintaining results (numbers of mature oocytes,
      percentage of pregnancy and live birth rates). On the other hand simultaneous blood sampling
      for measuring hormone levels is still the state of the art in many clinics. A large review
      (Cochrane review) stated that "although there was no clear evidence for a better outcome,
      combined cycle monitoring was still recommended until it could be proven that ovarian
      hyperstimulation can be avoided without hormonal monitoring". Investigators therefore perform
      a study that compares the results between 2 groups: those with ultrasound monitoring and
      those with combined monitoring. Deciding when to plan the retrieval of the oocytes can depend
      on subtle differences in the number of large follicles measured by ultrasound, but also on
      hormonal levels in the blood of the patient. Therefore the investigators planned a randomized
      study in the group of patients with combined monitoring. The investigators examined if
      delaying the moment for planning the moment of oocyte retrieval by 24 hours had any effect on
      the number of mature oocytes and pregnancy rates and what the effect of rising progesterone
      levels might be. The investigators hypothesis was that combined monitoring could lead to
      better results since recent studies have thought that rising progesterone levels, if found,
      have a negative impact on pregnancy rates. On the other hand the investigators expect to find
      that waiting for larger follicles in cases with normal progesterone levels lead to a better
      oocyte yield.
    


Intervention name(s): ultrasound; combined monitoring
Intervention type(s): Procedure; Procedure
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Comparison of Intravitreal Anti-VEGF Versus Combination Therapy in Central Retinal Vein Occlusion
Condition: Central Retinal Vein Occlusion With Macular Edema
MeSH terms: Macular Edema; Retinal Vein Occlusion; Edema
Study type: Interventional

Summary: 
      To compare the effect of intravitreal-Bevacizumab and Triamcinolone with
      intravitreal-Bevacizumab alone on visual acuity and central foveal thickness in patients with
      macular edema secondary to central retinal vein occlusion.
    


Intervention name(s): Group A
Intervention type(s): Drug
Intervention description(s): Combination of intravitreal triamcinolone acetonide (Kenacort-AⓇ) (2mg/0.05ml) and intravitreal bevacizumab (Avastin®) (1.25mg/0.05ml)
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: central retinal vein occlusion; macular edema; intravitreal bevacizumab
Effect of Beta-blocker on Cardioprotective Effect of Remote Ischemic Conditioning
Condition: Myocardial Infarction
MeSH terms: Myocardial Infarction; Infarction
Study type: Interventional
Phase: Phase 4

Summary: 
      Remote ischemic conditioning has been shown to protect myocardium from ischemia-reperfusion
      injury during cardiac intervention or cardiac surgery. However, effect of beta-blocker,
      commonly used cardiovascular medication in patients with cardiac diseases such as
      hypertension or angina pectoris, on cardioprotective role of remote ischemic conditioning has
      not been well documented. The purpose of the study is to investigate the effect of
      beta-blocker on remote ischemic conditioning in healthy volunteers.
    

Detailed description: 
      This study is prospective cross-over study investigating effect of beta-blocker on
      cardioprotective role of remote ischemic conditioning. Eleven male healthy volunteers are
      going to take oral beta-blocker (carvedilol, 12.5 mg once) or not before undergoing remote
      ischemic conditioning (consisting of 4 cycles of 5-min ischemia and subsequent 5-min
      reperfusion of upper arm), separated by 6-day wash-out period. To evaluate cardioprotective
      effect of remote ischemic conditioning, blood samples will be obtained before and after
      remote ischemic conditioning. Form the samples, human dialysate will be obtained and be
      perfused to rat heart through Langendorff apparatus before ischemia-reperfusion injury to the
      rat heart. Changes of infarct size of the rat heart will be compared between the beta-blocker
      and control groups.
    

Intervention name(s): Beta Blockers Carvedilol Phosphate
Intervention type(s): Drug
Intervention description(s): Subjects are going to take Beta Blockers Carvedilol Phosphate (12.5mg once) before undergoing remote ischemic conditioning.
Intervention MeSH terms: Carvedilol; Adrenergic beta-Antagonists
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: remote ischemic conditioning; beta-blocker
A Study of ALKS 5461 for the Treatment of Major Depressive Disorder (MDD) - the FORWARD-4 Study
Condition: Major Depressive Disorder
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 3

Summary: 
      This study will evaluate the efficacy and safety of ALKS 5461.
    


Intervention name(s): High Dose ALKS 5461; Low Dose ALKS 5461; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Sublingual tablet, taken once daily (in addition to open-label treatment with a commercially available antidepressant); Sublingual tablet, taken once daily (in addition to open-label treatment with a commercially available antidepressant); Sublingual tablet, taken once daily (in addition to open-label treatment with a commercially available antidepressant)
Other intervention name(s): ALKS 5461; ALKS 5461
Intervention MeSH terms: Naltrexone; Buprenorphine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Major Depressive Disorder; Depression; Alkermes; ALKS 5461; Samidorphan
Study of LY3074828 in Healthy Participants
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate different concentrations and formulations of
      LY3074828 compared to placebo ("dummy drug").

      The study will consist of 2 parts: Part A and Part B. Screening is required within 28 days
      prior to the start of each study part. For each participant in Part A and Part B, the total
      duration of the clinical trial will be approximately 16 weeks, including screening.
    


Intervention name(s): LY3074828; Placebo; LY900021
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Administered SC; Administered SC; Administered SC
Intervention MeSH terms: Mirikizumab
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Removable Devices in Palatal Expansion
Condition: Palatal Expansion Technique
Study type: Interventional

Summary: 
      The goal of this clinical trial si to compare two removable devices used to treat the
      transversal discrepancies in growing patients.

      The main questions it aims to answer are:

        -  the efficacy of the two devices in the palatal expansion

        -  the neuromuscolar effects developed on the stomatognatic system Participants will be
           instructed in the use and maintenance of the devices and will be checked every 15-30
           days for one year.
    


Intervention name(s): Elastodontic Device
Intervention type(s): Device
Intervention description(s): Removable device that embraces two dental archs
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: elastodontic device; growing patients; transversal palatal discrepancies
Evaluation of the Timing of the Nebulization Related to the Physiotherapy Session
Condition: Cystic Fibrosis
MeSH terms: Cystic Fibrosis
Study type: Interventional

Summary: 
      The purpose of this study is to determine the optimal time for the nebulization depending on
      the respiratory physiotherapy session in cystic fibrosis patients.
    


Intervention name(s): Airway clearance technique; Amikacin nebulization
Intervention type(s): Procedure; Drug
Intervention MeSH terms: Amikacin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Polyhexamethylene Biguanide Increases the Regression Rate of Human Papillomavirus (HPV) Infection
Condition: HPV Infection
MeSH terms: Infections; Papillomavirus Infections
Study type: Interventional
Phase: Phase 4

Summary: 
      Human papillomavirus (HPV) infection is a worldwide problem strictly linked to the
      development of cervical cancer. Persistence of the infection is one of the main factors
      responsible for the invasive progression and women diagnosed with intraepithelial squamous
      lesions are referred for further assessment and surgical treatments which are prone to
      complications. Despite this, there are several reports on the spontaneous regression of the
      infection.

      In this study the investigators will evaluate the effectiveness of a long term
      polyhexamethylene biguanide (PHMB)-based local treatment in improve the viral clearance
      reducing the time exposure to the infection and avoiding the complications associated with
      the invasive treatments currently available.

      Women diagnosed with HPV infection were randomly assigned to receive six months of treatment
      with a PHMB-based gynaecological solution (Monogin®) or to remain untreated for the same
      period of time.

      The administration of Monogin® has been performed every three days for fifteen days and then
      every fifteen days for the subsequent six months.
    


Intervention name(s): Monogin
Intervention type(s): Device
Intervention description(s): Gynaecological solution with polyhexamethylene biguanide, pH 4.0
Keywords: HPV; polyhexamethylene biguanide; intraepithelial lesions; regression rate
An Accessible Low-cost Plant Treatment for Cutaneous Ulcers
Condition: Yaws; Cutaneous; Cutaneous Ulcer; Yaws
MeSH terms: Skin Ulcer; Ulcer
Study type: Interventional
Phase: Phase 2

Summary: 
      In a search for accessible treatment options, plant medicines used by different communities
      in Papua New Guinea have been tested to identify the sap of the tree, Ficus septica, as a
      promising antibacterial agent in vitro.

      This is an open label clinical trial using an interventional approach, to compare the effect
      of the antiseptic plant sap and standard topical antiseptic, on the rate of wound development
      prevention and bacterial growth. If shown to be effective, this readily available plant
      medicine can provide a zero-cost treatment option in remote areas of PNG.
    

Detailed description: 
      The cutaneous ulcer is a painful and debilitating bacterial infection that is common in rural
      areas of Papua New Guinea (PNG). Systematic treatment with topical antiseptics such as
      chlorhexidine cream in theory represents a viable treatment option, but in reality, effective
      treatment of cutaneous ulcers in Papua New Guinea is greatly hindered by the remote and
      highly inaccessible areas that affected communities often live in. In a search for more
      accessible treatment options, plant medicines used by different communities in Papua New
      Guinea have been tested to identified the sap of the tree, Ficus septica, as a promising
      antibacterial agent in vitro. The sap displays comparable activity to chlorhexidine in disc
      diffusion assays with gram-positive bacterial wound pathogens. It also appears to dampen the
      pro-inflammatory responses of neutrophils by down regulating interleukin-6 expression. The
      sap forms a flexible plastic-like wound covering which may help deter flies from feeding on
      the wounds, and unlike chlorhexidine cream, the Ficus tree is easy to find where affected
      communities live. For this reason, this study aims to perform an open label clinical trial
      using an interventional approach, to compare the effect of this antiseptic plant sap and of a
      standard topical antiseptic, on the rate of wound development prevention and bacterial
      growth. If shown to be effective, this readily available plant medicine can provide a
      zero-cost treatment option in remote areas of PNG.
    

Intervention name(s): Topical antiseptic treatment
Intervention type(s): Biological
Intervention description(s): Prevent the development of bacterial cutaneous ulcers by applying antiseptic sap from Ficus septica tree on small wounds.
Intervention MeSH terms: Anti-Infective Agents, Local
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment