bioihbjkbjnl/mcl2 huggingface dataset:
The Use of Guide Wire in Biliary Cannulation: Angled or Straight Tipped Guide Wire?
Condition: Deep Biliary Cannulation
Study type: Interventional

Summary: 
      The purpose of the study is to prospectively evaluate the deep biliary cannulation in ERCP
      with the angled tipped guide wire or the straight tipped guide wire.
    

Detailed description: 
      Patients coming to ERCP examination are being divided randomly to two different groups. The
      deep biliary cannulation is started with predetermined guide wire. If the cannulation does
      not succeed in two minutes, the procedure is continued as normal.
    

Intervention name(s): angled and straight tipped guide wire
Intervention type(s): Procedure
Intervention description(s): Angled or straight tipped guide wire is used in the beginning of deep biliary cannulation in ERCP . If there is no success, other normal procedures (e.g. double wire cannulation and precut) are performed.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: ERCP; deep biliary cannulation; guide wire cannulation; post-ERCP pancreatitis; Success of deep biliary cannulation; Rate of post-ERCP pancreatitis; Time used to deep biliary cannulation
Impact of Disease Activity and Nutrition Treat on Postoperative Recurrence and Complications After Bowel Resection for Crohn's Disease
Condition: Crohn's Disease
MeSH terms: Crohn Disease; Recurrence
Study type: Interventional

Summary: 
      The study was aimed to determine whether perioperative nutrition treat and(or)the
      perioperative disease activity were associated with postoperative recurrence and
      complications after bowel resection for Crohn's disease.
    

Detailed description: 
      The investigators want to assess the impact of possible risk factors on intestinal resection
      and postoperative recurrence in Crohn's disease (CD) and to evaluate the disease course.

      In our clinical treatments, the investigators found that perioperative CDAI and nutrition
      treatment may have same impact on postoperative recurrence and complication in Crohn's
      disease. The investigators design this study to test it.

      The study prepare to collect the clinical data of patients who need bowel resection for CD to
      analyzed. The investigators divide those patients into two groups (N,I group). They accept
      intestinal nutrition with the respective aim that get the inflammatory index (erythrocyte
      sedimentation rate (ESR), C-reactive protein (CRP), Crohns Disease Activity Index (CDAI))
      norm or nutritional index norm before they accept surgery. Postoperative recurrence and
      complications in patients will be recorded and compared.
    

Intervention name(s): nutrition treat; surgery
Intervention type(s): Dietary Supplement; Other
Intervention description(s): intestinal nutrition treat :female：REE（Kcal/d）=655+9.6W+1.7H-4.7A; male：REE（Kcal/d）=66+13.7W+5.0H-6.8A;[W=weight（Kg）；H=height（cm）；A=age（year）]; bowel resection
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Crohn's disease; Nutrition; Bowel resection; Postoperative recurrence; complication; Active disease
Comparison of Laparoscopic Totally Extraperitoneal (TEP) and Lichtenstein Technique
Condition: Hernia, Inguinal
MeSH terms: Hernia; Hernia, Inguinal
Study type: Interventional

Summary: 
      Open tension-free mesh repair (Lichtenstein) and laparoscopic totally extraperitoneal (TEP)
      repair are the most commonly preferred techniques for inguinal hernia surgery. There's still
      a debate going on about which of these two techniques (open versus laparoscopic) is
      effective. This prospective randomized study aimed at comparing the early and long-term
      results of these two techniques (TEP vs. Lichtenstein).
    

Detailed description: 
      Various studies comparing the laparoscopic totally extraperitoneal (TEP) and Lichtenstein
      techniques have been reported. These studies have shown that TEP repair is associated with
      less postoperative pain and faster recovery. However, there are different views on the
      long-term (recurrence, chronic pain, etc.) results of the two techniques. This study was
      designed to compare the short- and long-term outcomes of open tension-free mesh repair
      technique(Lichtenstein) and laparoscopic repair technique(TEP).
    

Intervention name(s): inguinal hernia repair
Intervention type(s): Procedure
Intervention description(s): Patients who will undergo inguinal hernia repair will be divided into two groups(TEP versus Lichtenstein) according to the technique to be applied
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: hernia; laparoscopic; Lichtenstein
Package of Mentholated Measures for the Relief of Thirst in the Anesthesia Recovery Room
Condition: Thirst; Mouth Dryness; Irritation Lips
MeSH terms: Xerostomia
Study type: Interventional

Summary: 
      Package of mentholated measures for the relief of thirst in the anesthesia recovery room:
      Randomized clinical trial
    

Detailed description: 
      Perioperative thirst is intense and has a high incidence. There is evidence that strategies
      using cold and menthol could be viable alternatives to reduce thirst and the discomforts
      arising from it. For that reason, this study evaluated the efficacy of a mentholated package
      of measures (lip moisturizer and ice popsicle) compared to a non-mentholated package of
      measures in alleviating thirst in the anesthesia recovery room.
    

Intervention name(s): Mentholated lip moisturizer and ice popsicle; Non-mentholated lip moisturizer and ice popsicle
Intervention type(s): Other; Other
Intervention description(s): Mentholated package of measures; Non-mentholated package of measures
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Thirst; Ice; Menthol; Perioperative Nursing.; Recovery Room
Krill Oil Study Compared to Fish Oil
Condition: Healthy Volunteers
Study type: Interventional

Summary: 
      The main purpose of the study is to evaluate the absorption of omega-3 fatty acids into the
      blood following consumption of krill oil compared with fish oil and placebo.
    

Detailed description: 
      The main purpose of the study is to evaluate the absorption of omega-3 fatty acids into the
      blood following consumption of krill oil compared with fish oil and placebo. An additional
      purpose is to evaluate the lipid-lowering efficacy and safety of consumption of Krill Oil and
      Fish Oil to a placebo product. It has been shown that the ingestion of Krill Oil leads to
      better absorption of omega-3 fatty acids compared to ingestion of Fish Oil. It was also shown
      that consumption of krill oil and fish oil result in a favorable modification of lipid
      profiles. Therefore, it is anticipated that consumption of these krill oil and fish oil will
      improve lipid profile, as well as other health-related markers and will be safe and well
      tolerated.
    

Intervention name(s): Krill oil; Fish Oil
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Krill oil:Total omega-3 fatty acids: 560-660 mg and Astaxanthin: 1800 µg; Fish oil: Total omega-3 fatty acids: 560-660 mg
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Spacer Comparison In Adult Asthmatics
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 2

Summary: 
      Spacers are used by people with respiratory diseases who have problems using MDIs (metered
      dose inhalers). This study used fluticasone propionate/salmeterol to look at the
      pharmacokinetic profiles produced by different spacers in their washed and un-washed states.
    

Detailed description: 
      A randomised, open label, five-way crossover study to assess the systemic exposure of
      fluticasone propionate and salmeterol from SERETIDE™/ADVAIR™ 250 HFA MDI without spacer and
      with AeroChamber-Max spacer and VOLUMATIC™ both in their washed and unwashed states in adult
      subjects with mild or intermittent asthma.
    

Intervention name(s): fluticasone propionate/salmeterol
Intervention type(s): Drug
Intervention MeSH terms: Fluticasone; Xhance; Salmeterol Xinafoate
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: asthma; spacer
Safety, Tolerability, and Pharmacokinetics of GS-5745 in Subjects With Rheumatoid Arthritis
Condition: Rheumatoid Arthritis
MeSH terms: Arthritis; Arthritis, Rheumatoid
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is to assess the safety, tolerability, and pharmacokinetics (PK) of multiple
      infusions of GS-5745 in adults with rheumatoid arthritis (RA). Participants will be
      randomized in a 4:1 ratio to receive 1 intravenous (IV) infusion of GS-5745 or placebo every
      2 weeks, for a total of 3 IV infusions.
    


Intervention name(s): GS-5745; Placebo to match GS-5745
Intervention type(s): Drug; Drug
Intervention description(s): GS-5745 400 mg administered intravenously; Placebo to match GS-5745 administered intravenously
Intervention MeSH terms: Antibodies, Monoclonal
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: rheumatoid arthritis; RA; GS-5745; MMP9; phase 1
A Comparison of CPR Outcomes Between Traditional and Endomorphic Manikins With and Without Equipment
Condition: Cardiac Arrest
MeSH terms: Heart Arrest
Study type: Interventional

Summary: 
      The study's research design is a randomized experiment. 50 emergency responders (emergency
      medical responders, emergency medical technicians, advanced emergency medical technicians,
      and paramedics) will be recruited for this research. All data collection will take place in
      Lab 14 of the Benson Bunker Fieldhouse or a professional, confidential location of the
      participant's choosing.

      Prior to CPR performance, participants will be given an informed consent form to sign. The
      form will be explained in detail by the researcher collecting data. After obtaining informed
      consent, participants will be asked to fill out a demographic questionnaire to collect
      information such as age, gender, years of emergency responder experience/employment, and
      years of CPR certification. Demographic information provided by participants will be utilized
      in data analysis. The demographics form should take approximately five minutes to complete.
      Participants will be randomly assigned to the four trials they will partake in and instructed
      via oral script (one for over and one for under football shoulder pads) to perform
      four-trials total of three-minute single-rescuer CPR on both a traditional CPR manikin and
      "Fat Old Fred" (bariatric) CPR manikin. CPR must be performed in accordance with the American
      Heart Association's 2015 CPR Guidelines and participants will use a CPRmeter 2 device to
      collect data to determine the quality of CPR components (chest compression depth/recoil,
      compression rate, CPR compression duration, mean depth, mean rate, and total number of
      compressions). The entire study session should take 25 to 30 minutes to complete.
    


Intervention name(s): Cardiopulmonary Resuscitation
Intervention type(s): Other
Intervention description(s): Cardiopulmonary Resuscitation based on 2015 American Heart Association guidelines with and without protective equipment on traditional and endomorphic manikins
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Treatment
HD17 for Intermediate Stage Hodgkin Lymphoma
Condition: Hodgkin Lymphoma
MeSH terms: Lymphoma; Hodgkin Disease
Study type: Interventional
Phase: Phase 3

Summary: 
      This study is designed to test the non-inferiority of the experimental arm compared to the
      standard arm in terms of progression free survival (PFS).
    


Intervention name(s): BEACOPPescalated (Bleomycin, Etoposide, Adriamycin, Cyclophosphamide, Vincristine, Procarbazine, Prednisone); ABVD (Adriamycin, Bleomycin, Vinblastine, Dacarbazine); 30Gy IF-RT (Involved-Field Radiotherapy); 30Gy IN-RT (Involved-Node Radiotherapy)
Intervention type(s): Drug; Drug; Radiation; Radiation
Intervention MeSH terms: Prednisone; Cyclophosphamide; Dacarbazine; Etoposide; Vincristine; Doxorubicin; Liposomal doxorubicin; Bleomycin; Vinblastine; Procarbazine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Hodgkin Lymphoma; intermediate stage; PET
Enhanced Recovery After Laparoscopic Colorectal Surgery
Condition: Rectal Cancer; Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional
Phase: Phase 4

Summary: 
      Investigators would like to test the effects of spinal anesthesia as an adjunct to general
      anesthesia in patients undergoing laparoscopic abdominoperineal rectal amputation.
      Investigators hypothesize that spinal anesthesia as an adjunct to general anesthesia will
      reduce postoperative pain and opioid requirements.
    

Detailed description: 
      Effective pain management after laparoscopic rectal surgery is a fundamental requirement in
      an enhanced recovery after surgery program (ERAS). Opioids remain the mainstay for
      postsurgical pain despite well documented side effects including sedation, dizziness, nausea,
      vomiting, constipation, physical dependence, tolerance, and respiratory depression. Spinal
      analgesia as an adjunct to general anesthesia has not been studied in laparoscopic rectal
      surgery, but data from studies of patients undergoing colon cancer resection indicate a
      positive analgesic effect of spinal anesthesia as an adjunct to general anesthesia. When an
      ERAS program was used for laparoscopic colonic resection, It has been showed that an
      intrathecal mixture of bupivacaine and morphine was associated with less postoperative opioid
      consumption. In a more recent paper intrathecal morphine was a more effective method for
      treating postoperative pain in laparoscopic colon surgery than intravenous opioids within an
      ERAS program. In the present proposal the investigators would like to test the effects of
      spinal anesthesia as an adjunct to general anesthesia in patients undergoing laparoscopic
      abdominoperineal rectal amputation. It was hypothesized that spinal anesthesia as an adjunct
      to general anesthesia would reduce postoperative pain and opioid requirements.
    

Intervention name(s): Bupivacaine Injection
Intervention type(s): Drug
Intervention description(s): One group will receive bupivacaine 15 mg and morphine 100 ug intrathecally
Other intervention name(s): Marcain
Intervention MeSH terms: Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
The Effect of Basic Body Awareness Therapy on Musculoskeletal Disorders and Psychological Symptoms
Condition: University Students
MeSH terms: Musculoskeletal Diseases
Study type: Interventional

Summary: 
      During the coronavirus disease (COVID-19) pandemic, stay-at-home isolation as a precaution to
      alleviate the disease has affected the physical and mental well-being of individuals.
      University students spent time in front of the screen with online education and developed a
      sedentary lifestyle during the academic term. In this process, musculoskeletal disorders
      increased more in university students due to the increase in the use of laptop or computer,
      smartphone, and social media. The COVID-19 pandemic has caused psychological disorders as
      well as physical health problems. General population studies have shown that all forms of
      depression, anxiety, stress, sleep problems, and psychological distress are highly increased
      during this period. In a study conducted in Turkey, it was reported that students' negative
      well-being, anxiety, and physical inactivity significantly affected perceived stress during
      the COVID-19 pandemic, and students' mental health was at high risk. It has been stated that
      providing mental health supportive systems in students and encouraging physical activity
      regularly can reduce perceived stress levels.

      On the other hand, psychological interventions via video conferencing platforms have been
      proposed to promote mental health due to the limited and delayed face-to-face healthcare as a
      result of the COVID-19 pandemic. It has been stated that the use of telemedicine or e-health
      applications together with body-mind approaches such as yoga, tai chi, qigong may be
      beneficial in order to encourage physical activity and protect mental health in this critical
      period. Basic Body Awareness Therapy (BBAT), which is among the body-mind approaches, is also
      frequently used in the rehabilitation of patients with psychiatric disorders, pain, and
      chronic musculoskeletal system problems. Therefore, the aim of this study is to evaluate the
      effect of BBAT on musculoskeletal disorders and psychological symptoms in university students
      who participated in the hybrid (online + face-to-face) education program during the COVID-19
      pandemic. The importance of this study is that it is the first study on physical and
      psychological symptoms of BBAT in university students.
    


Intervention name(s): Basic Body Awareness Therapy
Intervention type(s): Other
Intervention description(s): Basic Body Awareness Therapy (BBAT), which is among the body-mind approaches, is also frequently used in the rehabilitation of patients with psychiatric disorders, pain, and chronic musculoskeletal system problems.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Basic Body Awareness Therapy; COVID-19; Musculoskeletal Pain; telerehabilitation; mental health
Comparison of 2 Different Hook-up Protocols to Perform Home-based Polysomnography
Condition: Sleep Disordered-breathing
MeSH terms: Respiratory Aspiration; Sleep Apnea Syndromes
Study type: Interventional

Summary: 
      Comparison of 2 hook-up protocols to perform home-based sleep studies in patients suspected
      of sleep-disordered breathing.

      First one: hook-up is performed in the hospital, around 4 PM, and the patient go home with
      the portable monitoring.

      Second one: hook-up is performed home, around 7 PM, and the patient has not to move after
      hook-up.
    

Detailed description: 
      All the patients will undergo 2 polysomnographies, according to two different hook-up
      protocols, within 2 weeks. Order of the exams will be randomized.

      We hypothesised that quality of recording is better when hook-up is performed at home.

      Final polysomnographic diagnosis, with the 2 different techniques, must be similar.
    

Intervention name(s): polysomnography
Intervention type(s): Device
Intervention description(s): home-based polysomnography with hook-up performed ar at home or in the hospital
Other intervention name(s): sleep study
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Investigator)
Primary purpose: Diagnostic
Keywords: polysomnography; portable monitoring; sleep; sleep disordered breathing; home based polysomnography
Human Heterologous Liver Cells for Infusion in Children With Urea Cycle Disorders
Condition: Urea Cycle Disorders; Carbamoylphosphate Synthetase I Deficiency; Ornithine Transcarbamylase Deficiency; Citrullinemia
MeSH terms: Urea Cycle Disorders, Inborn; Ornithine Carbamoyltransferase Deficiency Disease; Citrullinemia; Carbamoyl-Phosphate Synthase I Deficiency Disease
Study type: Interventional
Phase: Phase 2

Summary: 
      Urea cycle disorders are rare inherited diseases that generally have a poor outcome. In this
      study, neonates and infants with UCD will be included within the first 3 months of life and
      will be treated by repetitive application of human liver cells to reduce the risk of
      neurological deterioration while awaiting OLT.
    

Detailed description: 
      Urea cycle disorders are rare inherited diseases that generally have a poor outcome,
      especially with onset of the disease in the neonatal period. UCDs are caused by a deficiency
      of one of six enzymes responsible for removing ammonia from the bloodstream. Instead of being
      converted into urea which is removed from the body with the urine, ammonia accumulates in UCD
      patients leading to brain damage or death. In the light of a mortality rate of > 50% at the
      age of 10 years the current pharmacological and dietary therapy is of modest success.
      Furthermore, mental retardation, cerebral palsy and other neurological sequelae are common
      among surviving patients.

      In the last years, orthotopic liver transplantation (OLT) has become the best therapeutic
      option for UCD with long-term survival rates of about 90%. However, in the first weeks of
      life OLT still is technically demanding and prone to complications. With larger size of the
      recipient, the technical problems with OLT decrease considerably. The increased body weight
      usually achieved at the age of more than 8 weeks is related to a major reduction in
      transplantation related morbidity. Stabilization of metabolism until the patient can undergo
      OLT is essential.

      In this study, neonates and infants with UCD will be included within the first 3 months of
      life and will be treated by repetitive application of human liver cells. In the last
      consequence, the aim of this new therapy option is to supply a sufficient amount of healthy
      liver cells to compensate for the metabolic defect and to reduce the risk of neurological
      deterioration while awaiting OLT.
    

Intervention name(s): Human Heterologous Liver Cells
Intervention type(s): Biological
Intervention description(s): Multiple applications of liver cell suspension for infusion
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Urea cycle Disorders; Carbamoylphosphate synthetase I deficiency; Ornithine transcarbamoylase deficiency; Argininosuccinate synthase deficiency; Citrullinemia; newborns; infants; liver cell transplantation; liver cell infusion
Effects of Inspiratory Muscle Training in COPD
Condition: COPD; Inspiratory Muscle Weakness
MeSH terms: Muscle Weakness; Respiratory Aspiration
Study type: Interventional
Phase: Phase 3

Summary: 
      The additional effect of inspiratory muscle training as an adjunct to a general exercise
      training program in patients with COPD with inspiratory muscle weakness will be studied. The
      main hypothesis is that inspiratory muscle training combined with an exercise training
      program improves functional exercise capacity more than an exercise training program without
      the addition of an inspiratory muscle training program.
    


Intervention name(s): Inspiratory Muscle Training
Intervention type(s): Procedure
Intervention description(s): Three times daily inspiratory muscle training (2x30 breaths) at an intensity of >50% Pi,max
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment