bioihbjkbjnl/mcl2 huggingface dataset:
Functional Movement Analysis (FMS) of Diaphragmatic Breathing-Immediate Effect on Shoulder Mobility
Condition: Shoulder Pain; Diaphragm Issues
MeSH terms: Shoulder Pain
Study type: Interventional

Summary: 
      The diaphragm is defined as a thin, smooth muscle that separates the thoracic and abdominal
      cavities. The shoulder and diaphragm muscle have a clear relationship through innervation and
      myofascial tissue connection. Fascia is often neglected medically, rehabilitatively, or
      performance as the underlying cause of problems. Bones, organs, and muscles appear to float
      in the fascial web, a continuous three-dimensional system of connective tissue. Plastic and
      viscoelastic properties, which can change tension and shape under the influence of manual
      techniques and movement retraining, ensure that the structural changes are reversible.
      Functional Movement Analysis (FMS) is a screening system that aims to predict the risk of
      injury and functional deficiencies. FMS consists of 7 basic motion component tests. It is
      scored on a scale of zero to three and creates a composite score whose sum ranges from 0 to
      21 points. One of the 7 motion models evaluated is shoulder mobility. According to the
      results of this study, people who perform activities that require shoulder mobility will be
      guided as to whether the use of diaphragmatic breathing will be effective for preparation,
      rehabilitation or performance improvement. The aim of the study was to observe whether
      shoulder mobility increased in healthy individuals taught diaphragm breathing compared to the
      control group.
    


Intervention name(s): Shoulder Mobility; Diaphragmatic Breathing
Intervention type(s): Other; Procedure
Intervention description(s): t is one of the seven functional movements studied in FMS. This test requires the participant to simultaneously hold one hand behind the back (internal rotation) and the other hand behind the head (external rotation) with the fisted hands, and bring the hands as close to each other as possible in the back area. The distance measurement in cm is taken with a tape measure between 3 fingers of both hands.; The participant will lie on his back in a comfortable position, diaphragmatic breathing will be taught first in the application group and he will be asked to do diaphragmatic breathing for 90 seconds. At the end of this period, the participant will be referred back to the evaluator physiotherapist, and the physiotherapist will evaluate the shoulder mobility again without knowing which group the participant is in.
In the participant control group, shoulder mobility will be evaluated and the practitioner will be asked to stay in a comfortable position on his back for 90 seconds next to the physiotherapist. At the end of the period, shoulder mobility will be evaluated again by the assessing physiotherapist.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Diaphragmatic Breathing; Functional Movement Analysis (FMS); Shoulder Mobility
Efficacy of Capacitive-Resistive Therapy on the Treatment of Myofascial Pain
Condition: Myofascial Pain Syndrome of Neck
MeSH terms: Myofascial Pain Syndromes; Fibromyalgia
Study type: Interventional

Summary: 
      Myofascial pain syndrome (MPS) is a painful musculoskeletal condition affecting the
      individuals' daily life presenting with muscle spasm, referred pain patterns, stiffness,
      restricted range of motion caused by trigger points. Capacitive-resistive diathermy therapy
      heats deep tissues by transferring energy through radiofrequency waves. Currently, although
      this modality is used to treat various acute or chronic musculoskeletal disorders, there is
      no specific data about myofascial trigger points in the literature. The investigators aimed
      to evaluate the efficacy of capacitive-resistive diathermy on the myofascial trigger point of
      neck/upper trapezius muscle area compared with the sham intervention of capacitive-resistive
      diathermy.

      Volunteers with active myofascial trigger points in the upper trapezius and neck were
      included the study after being examined by sports medicine specialists. Exclusion criteria
      were fibromyalgia, discal hernia, radiculopathy, myelopathy, having received trigger point
      injection and physical therapy within the last 1 month, neck or back surgery, rheumatismal
      diseases, pregnancy. Patients were randomly allocated into two groups. Group 1 will be
      treated with capacitive resistive diathermy and exercise. Group 2 will be treated with
      placebo (sham) capacitive-resistive diathermy and exercise for 10 sessions at intervals of
      24-48 hours. Visual analog scale (VAS), neck disability index (NDI) score, cervical range of
      motion (cROM), active trigger point numbers will be evaluated before and after treatment. The
      study was designed as a prospective, randomized, placebo-controlled double-blind trial. The
      study was approved by the Istanbul Faculty of Medicine Ethics Committee. All participants
      were informed of the study and signed written informed consent.
    


Intervention name(s): Capacitive-Resistive Therapy
Intervention type(s): Device
Intervention description(s): Capacitive-resistive diathermy therapy heats deep tissues by transferring energy through radiofrequency waves.
Other intervention name(s): Exercise
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Myofascial Neck Pain; Capacitive-resistive Therapy
Inhaled Fentanyl Citrate & Dyspnea
Condition: Dyspnea
MeSH terms: Dyspnea
Study type: Interventional
Phase: Early Phase 1

Summary: 
      "Dyspnea" refers to the awareness of breathing discomfort that is typically experienced
      during exercise in health and disease. In various participant populations, dyspnea is a
      predictor of disability and death; and contributes to exercise intolerance and an adverse
      health-related quality-of-life. It follows that alleviating dyspnea and improving exercise
      tolerance are among the principal goals of disease management. Nevertheless, the effective
      management of dyspnea and activity-limitation remains an elusive goal for many healthcare
      providers and current strategies aimed at reversing the underlying chronic disease are only
      partially successful in this regard. Thus, research aimed at identifying dyspnea-specific
      medications to complement existing therapies for the management of exertional symptoms is
      timely and clinically relevant. The purpose of this study is to test the hypothesis that
      single-dose inhalation of fentanyl citrate (a mu-opioid receptor antagonist) will improve the
      perception of dyspnea during strenuous exercise in healthy, young men in the presence of an
      external thoracic restriction. To this end, the investigators plan compare the effects of
      inhaled 0.9% saline placebo and inhaled fentanyl citrate (250 mcg) on detailed assessments of
      neural respiratory drive (diaphragm EMG), ventilation, breathing pattern, dynamic operating
      lung volumes, contractile respiratory muscle function, cardio-metabolic function and dyspnea
      (sensory intensity and affective responses) during symptom-limited, high-intensity,
      constant-work-rate cycle exercise testing with and without external thoracic restriction in
      healthy, men aged 20-40 years.
    


Intervention name(s): Fentanyl Citrate; CWS; Placebo
Intervention type(s): Drug; Other; Drug
Intervention description(s): Chest wall strapping to reduce vital capacity by 20% of its baseline value; 0.9% saline
Other intervention name(s): chest wall strapping
Intervention MeSH terms: Fentanyl
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Fentanyl Citrate; Opioids; Exercise
Long Term Immunity and Safety Following Vaccination With the JEV IC51 (IXIARO®, JESPECT®) in Pediatric Population In Non Endemic Countries. Uncontrolled, Ph3 FU-Study
Condition: Japanese Encephalitis
MeSH terms: Encephalitis, Japanese; Encephalitis
Study type: Interventional
Phase: Phase 3

Summary: 
      The study investigates long-term immunity and safety of IC51 (IXIARO®, JESPECT®) in a
      pediatric population vaccinated in the parent study IC51-322.
    


Intervention name(s): Blood draw; IC51 has given in the parent study IC51-322
Intervention type(s): Procedure; Biological
Intervention description(s): blood draw at Month 12, Month 24 and Month 36.; No more vaccinations in IC51-324 since this a study for long-term follow-up on safety and immunogenicity after vaccinations in parent study IC51-322.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Cognitive Behavioral Therapy for Post-Traumatic Stress Disorder in Individuals With Severe Mental Illness
Condition: Stress Disorders, Post-Traumatic; Schizophrenia
MeSH terms: Schizophrenia; Stress Disorders, Traumatic; Stress Disorders, Post-Traumatic
Study type: Interventional
Phase: Phase 2

Summary: 
      This study will develop a cognitive behavioral therapy (CBT) program to treat symptoms of
      post-traumatic stress disorder (PTSD) in people with severe mental illnesses who are treated
      within community mental health systems.
    

Detailed description: 
      A significant proportion of people with SMI who are treated within the public sector also
      suffer from PTSD. Evidence suggests that these individuals often receive inadequate mental
      health services because effective treatments have not been explored. This study will develop
      and implement a CBT treatment that is designed specifically for the SMI/PTSD population.

      In the first year of the study, a treatment manual and a CBT treatment model, including
      education, social skills training, and exposure therapy, will be developed. In the following
      two years, the treatment program will be tested in individuals with SMI and PTSD. Scale
      ratings, self-report checklists, and daily logs of behavior will be used to assess PTSD
      symptoms. Scale ratings and self-report surveys will also be used to measure hostility,
      functional status, depression and schizophrenia symptoms, and satisfaction with the study.
      Assessments will be made throughout the study.
    

Intervention name(s): Cognitive Behavioral Therapy (CBT)
Intervention type(s): Behavioral
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Psychotic Disorders
Bioequivalence Study Comparing Arimidex Tablet and Anastrozole ODF in Japanese Healthy Male Subjects
Condition: Safety; Pharmacokinetics
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is to investigate whether anastrozole ODF is bioequivalent with Arimidex tablet
      after a single oral administration of each anastrozole formulation.
    

Detailed description: 
      A Randomised, Open label, Single centre, 2 way Crossover Bioequivalence Study Comparing
      Arimidex Tablet 1 mg and Anastrozole Orally Rapid Disintegration Film Formula 1 mg After
      Single Oral Administration in Japanese Healthy Male Subjects
    

Intervention name(s): Anastrozole ODF; Arimidex tablet; Anastrozole ODF; Arimidex tablet
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Each volunteer will receive a single dose of Anastrozole ODF with water.; Each volunteer will receive a single dose of Arimidex tablet with water; Each volunteer will receive a single dose of Anastrozole ODF without water.; Each volunteer will receive a single dose of Arimidex tablet with water
Intervention MeSH terms: Anastrozole
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Bioequivalence; pharmacokinetics; safety; anastrozole; Arimidex; Japanese; healthy subject
Milk Protein and Bone Health in Postmenopausal Women
Condition: Bone and Bones; Osteoporosis Risk; Osteoporosis, Postmenopausal
MeSH terms: Osteoporosis; Osteoporosis, Postmenopausal
Study type: Interventional

Summary: 
      The process of bone remodeling exhibits pronounced diurnal pattern that is important for bone
      health. A balanced rate of bone resorption is required to maintain bone health, a balance
      that can be disturbed during the life-cycle to effect net rate of formation (as occurs during
      growth and development to adulthood) or net resorption (as occurs, for example, during the
      menopause). Bone turnover is a nutritionally modulated process and the investigators believe
      a milk-based protein supplement (MBPS) can modulate beneficially the rate of bone resorption
      over the time period when bone remodeling is most active i.e. late evening/overnight. In this
      novel approach to the timing of nutrient ingestion, the proposed nutrient intervention seeks
      to modify (reduce) the rate of bone resorption and promote the rate of bone formation to the
      benefit of bone health in this at risk population..
    

Detailed description: 
      Study design:

      A block randomised, controlled study among healthy, post-menopausal women with osteopenia
      receiving a milk-based protein supplement (MBPS) in the evening, or not,(CONTROL) for a
      period of 24 weeks.

      Composition of MBPM - 25g of milk-based proteins + 1000mg dairy-based calcium fortified with
      40ug Vit D flavoured and textured. All formulations to be supplied food grade and product
      tested by Dairygold Co-operative Society, Mitchelstown, Ireland.

      Participants:

      60 Post-menopausal women with osteopenia as determined by site-specific bone mineral density
      BMD (DXA) diagnosed and screened by a clinician and for dietary intake of calcium and Vit D
      by a clinical dietitian.
    

Intervention name(s): Milk-based protein matrix (MBPM); Habitual dietary behaviour
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Ingestion of the Test Product at 10:00 pm, post-absorptive of the evening meal, each day for the 24 week period of intervention; Subjects to maintain habitual dietary behaviour for the 24 week intervention
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A block randomised, controlled study among healthy, post-menopausal women with osteopenia receiving a milk-based protein supplement (MBPS) in the evening, or not (CONTROL), for a period of 24 weeks.
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Osteoporosis; Postmenopausal; Bone Turnover Markers; Dairy Products
Pre-probiotic Supplementation for Post-covid Fatigue Syndrome
Condition: Long COVID
MeSH terms: Post-Acute COVID-19 Syndrome; Fatigue
Study type: Interventional

Summary: 
      The goal of this randomized controlled double-blind parallel-group interventional trial is to
      evaluate the effects of of dietary supplementation with a pre-probiotic on patient- and
      clinician-reported outcomes, and brain tissue metabolism in patients with post-covid fatigue
      syndrome.
    


Intervention name(s): Dietary Supplement: Experimental; Dietary Supplement: Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Combination of pre-probiotic; Inert compound
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Supportive Care
Keywords: Prebiotic; Probiotic; Metabolism; Fatigue
Luminopia One Pilot Study
Condition: Amblyopia
MeSH terms: Amblyopia
Study type: Interventional

Summary: 
      A single-arm, multi-center, open-label pilot study to evaluate the feasibility, safety, and
      efficacy of the Luminopia One digital therapeutic in improving visual acuity in a pediatric
      amblyopia population.
    


Intervention name(s): Luminopia One
Intervention type(s): Device
Intervention description(s): Luminopia One is a digital therapeutic that allows patients to watch videos with therapeutic modifications applied.
Intervention model: Single Group Assignment
Intervention model description: A single-arm, multi-center, open-label pilot study conducted in two phases. Phase 1 enrolled 10 participants at 1 site and phase 2 enrolled 74 participants at 9 sites.
Masking: None (Open Label)
Primary purpose: Treatment
A Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of JNJ-28431754 in Patients With Type 2 Diabetes Mellitus
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (ie,
      blood levels of JNJ-28431754) and pharmacodynamics (ie, urine and blood levels of glucose) of
      JNJ-28431754 compared to placebo in patients with Type 2 diabetes mellitus.
    

Detailed description: 
      This is a randomized (study drug assigned by chance), double-blind (neither physician,
      patient nor the sponsor knows the assigned treatment), placebo-controlled, single and
      multiple (14 days) ascending dose, parallel group study in 3 study centers (United States,
      Germany and South Korea). Five cohorts (groups) of patients with Type 2 diabetes mellitus
      (T2DM) will be studied. One dose level will be evaluated in each cohort. Sixteen (16)
      patients will be randomly assigned to receive JNJ-28431754 and four (4) patients to receive
      matching placebo within each cohort. The planned doses are 30, 100, 300 and 600 mg per day.
      Twice-daily dosing may also be evaluated in one or more of the cohorts. An additional cohort
      of Asian patients will also be evaluated at a dose level, which was previously tested in a
      prior cohort and considered to be well tolerated. Blood and urine samples will be collected
      from patients during the study for pharmacokinetic and pharmacodynamic assessments. The
      safety and tolerability of JNJ-28431754 will be monitored throughout the study.
    

Intervention name(s): JNJ 28431754; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): A liquid suspension of 30 mg, 100 mg, 300 mg of JNJ-28431754 taken once (or twice) daily or 600 mg taken once daily will be administered by study personnel directly into the patient's mouth using an oral liquid dispenser for 14 days (Day 1 and Days 3 through 16).; A liquid suspension of placebo will be administered by study personnel directly into the patient's mouth using an oral liquid dispenser once or twice daily for 14 days (Day 1 and Days 3 through 16).
Other intervention name(s): Canagliflozin
Intervention MeSH terms: Canagliflozin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Diabetes Mellitus, Type 2; JNJ-28431754; Canagliflozin; Sodium Glucose Co-transporter (SGLT2 inhibitor); Pharmacokinetics; Pharmacodynamics
Evaluation of Air Abrasion Surface Pretreatment in the Repairing Capacity of Defective Composite Restoration
Condition: Repair
Study type: Interventional

Summary: 
      This study is conducted to compare the efficacy of surface pretreatment using air abrasion
      sandblasting aluminum oxide particles (Al2O3) versus not pretreatment in the repair capacity
      of defective composite restoration indicated for repair.
    

Detailed description: 
      First the rationale for the repair, rather than the replacement of defective direct composite
      restorations proved a less invasive procedure with decreased tooth loss avoiding weakening
      and overtreatment of tooth. Less traumatic or stressful than replacement for patients with
      good acceptance; Increased longevity of the restoration; Reduction of potentially harmful
      effects on the dental pulp and Less risk of iatrogenic damage to adjacent teeth.

      Secondary using surface treatment strategies aim to prepare a clean surface with high surface
      energy to provide better wettability with adequate surface roughness and surface area by
      removing the superficial layer of the aged composite which lead to increase integrity between
      old and new resin restoration.
    

Intervention name(s): Air abrasion sandblasting aluminum oxide particles (Al2O3) AquaCare single (Velopex, Medivance Instruments Ltd., London, UK)
Intervention type(s): Device
Intervention description(s): Air abrasion sandblasting aluminum oxide particles (Al2O3) Aqua Care single (London, UK) will be done for the defective area then repairing with bioactive injectable composite, Beautiful Flow Plus X F00 (Shofu, Japan).
Other intervention name(s): sandblasting
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: repair; defective restoration; sandblasting
A Study to Evaluate How VI-0521 Affect Psychomotor Performance in Healthy Overweight and Obese Subjects.
Condition: Overweight; Obesity
MeSH terms: Overweight
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine how VI-0521 affect speed and reaction time on
      specific tasks that require eye and hand coordination, compared to placebo.
    


Intervention name(s): VI-0521; Placebo; Alcohol; alcohol placebo
Intervention type(s): Drug; Drug; Other; Other
Intervention description(s): Phentermine 3.75 mg and topiramate 23 mg daily for the 1st week; Phentermine 7.5 mg and topiramate 46 mg daily for the 2nd week; Phentermine 11.25 mg and topiramate 69 mg daily for the 3rd week; Phentermine 15 mg and topiramate 92 mg daily for the 4th week; Placebo daily for 4 weeks; fruit juice
Intervention MeSH terms: Ethanol
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Overweight; Obesity; coordination; psychomotor
Safety and Efficacy Study of Cefdinir Oral Suspension, in Pediatric Subjects to Treat Acute Otitis Media
Condition: Acute Otitis Media
MeSH terms: Otitis; Otitis Media
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      To evaluate the safety and efficacy of cefdinir oral suspension in children between 6 months
      and 4 years of age, with acute otitis media, who are at risk of persistent or recurrent
      otitis media.
    


Intervention name(s): cefdinir
Intervention type(s): Drug
Intervention description(s): cefdinir oral suspension, 25 mg/kg once daily for 10 days
Other intervention name(s): ABT-198, Omnicef, cefdinir
Intervention MeSH terms: Cefdinir
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment