Whole Body Vibration Training and Breast Cancer Risk Factors
Condition: Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Interventional

Summary: 
      study aim is to determine the effect of whole body vibration training (WBVT) on body mass
      index, serum prolactin concentration as a risk factors for breast cancer and severity of hot
      flashes in obese postmenopausal women.
    

Detailed description: 
      Menopause is a physiological process characterized by spontaneous cessation of menstrual
      cycle lasting at least 12 months, it is normally occurring in women aged 45 - 55 years .
      Postmenopausal women have higher prevalence of menopausal symptoms that significantly affect
      their quality of life more than pre- and perimenopausal women .

      Increased adiposity, as measured by high body mass index, is associated with more severe
      menopausal symptoms also, obese female has a high risk lifestyle for the development of
      post-menopausal breast cancer .

      The link between BMI and breast cancer risk is likely to be due to increased concentrations
      of bioavailable estradiol, which results in turn from an increase in the production of
      estrogens by aromatase in the adipose tissue, conversion of hormones in fatty tissue and a
      decrease in the serum concentration. This is likely to explain the higher risk of breast
      cancer in overweight post-menopausal women .

      Menopause is also associated with atherogenic changes, including a worsening of CVD risk
      factors and decreased aerobic fitness compared with premenopausal women.

      This initially may be due to a decrease in endogenous estrogen levels, and likely further
      exacerbated by increased adiposity and reductions in exercise habits or physical activity
      levels.

      Post menopausal women recorded a high serum prolactin concentration however, they have a
      significant chance of normalizing their prolactin levels.

      Serum prolactin levels rise transiently after several physiological states including
      pregnancy, breast-feeding, exercise, meals, sexual intercourse, minor surgical procedures,
      general anesthesia, other forms of acute stress and menopause.

      Estrogen is another key regulator of prolactin and has been shown to increase the production
      and secretion of prolactin from the pituitary gland. In addition to dopamine and estrogen, a
      whole range of other hormones can both increase and decrease the amount of prolactin released
      in the body, with some examples being thyrotropin-releasing hormone, oxytocin and
      anti-diuretic hormone .

      Whole-body vibration training is a promising adjunct intervention therapy for management of
      obesity, as there is few evidence that it can reduces body mass index and enhances muscles
      strength.

      In initial stage of obesity management, WBVT is highly recommended because it allows a mild
      joints stress, deconditioning for obese patient with poor motivation because it achieve its
      target without provoking an excessive fatigue. In addition, Passive vibrations do not involve
      voluntary movement and need a lower contribution of central command, so WBVT is as effective
      as aerobic and resistance exercise in reducing fat mass and moderating the deficit of the
      relative muscle strength . Lastly, WBVT may be effective in vascular health promotion and
      prevention in young obese women.

      Whole body vibration training(WBVT) has been recognized as an effective alternative exercise
      modality to resistance exercise for its ability in enhancing force and power, generating
      capacity in skeletal muscle, increasing bone mass, improving cardiovascular function,
      reducing fat mass and moderating the deficit of the relative muscle strength. Unfortunately,
      the effect of resistance exercise on prolactin has not been extensively studied .

      So, this study was conducted to evaluate the effect of whole body vibration training on BMI,
      waist circumference, serum prolactin concentration and hot flashes in obese postmenopausal
      women.
    

Intervention name(s): whole body vibration training
Intervention type(s): Device
Intervention description(s): Oscillating platform
Other intervention name(s): (WBVT)
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: prospective study
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Breast Cancer; Hot Flashes; Prolactin; Whole Body Vibration