bioihbjkbjnl/mcl2 huggingface dataset:
Effect of Dexamethasone Combined With Ondansetron on Postoperative Nausea and Vomiting in Patients With Patient-controlled Analgesia After Video-assisted Thoracoscopic Surgery
Condition: Nausea; Vomiting
MeSH terms: Nausea; Vomiting; Postoperative Nausea and Vomiting
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to study the effect of dexamethasone combined with ondansetron
      on postoperative nausea and vomiting in patients with patient-controlled analgesia after
      video-assisted thoracoscopic surgery.
    


Intervention name(s): Dexamethasone; Ondansetron
Intervention type(s): Drug; Drug
Intervention description(s): Experimental: Dexamethasone 8 mg IV after induction of anesthesia, Ondansetron 4 mg IV at the end of surgery and 12 mg mix to intravenous patient controlled analgesia device.; Active comparator: Ondansetron 4 mg IV at the end of surgery and 12 mg mix to intravenous patient controlled analgesia device.
Intervention MeSH terms: Dexamethasone; Ondansetron
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Keywords: Postoperative nausea and vomiting after video-assisted thoracoscopic surgery
Feasibility of Medical Abortion by Direct-to-Consumer Telemedicine
Condition: Pregnancy
Study type: Observational

Summary: 
      This pilot study is designed to obtain preliminary data on the safety, acceptability, and
      feasibility of direct-to-consumer telemedicine abortion.
    

Detailed description: 
      The objective of this pilot study is to obtain preliminary data on the safety, acceptability,
      and feasibility of direct-to-consumer telemedicine abortion.
    

Intervention name(s): medical abortion
Intervention type(s): Drug
Intervention description(s): medical abortion
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Women seeking abortion
The Effect of Exercise on Hepatic Glucose Metabolism
Condition: Obesity; Type 2 Diabetes
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      It is known that obesity and/or physical inactivity greatly increase a person's risk of
      developing heart disease and other serious health problems. This is partly because diabetes
      is associated with inflammation, oxidative stress, and insulin resistance. Diabetes is also
      associated with high levels of triglycerides in the blood and tissues such as the liver
      (known as fatty liver or steatosis). This elevation of fat in the liver is known to cause
      liver insulin resistance and impair the function of the liver and this impairment contributes
      to the development of diabetes.

      Studies have shown that both aerobic exercise and weight loss have beneficial results on
      insulin resistance. However, the cause of this benefit remains unclear. We know that both
      aerobic exercise and/or weight loss can improve how muscle responds to insulin. However, it
      is also known that aerobic exercise and/or weight loss lowers liver fat content, thereby
      making it possible that the liver's response to insulin is also improved by weight loss
      and/or exercise training. An improved responsiveness of the liver to insulin could lower
      blood sugar levels after a meal and it could also lower morning blood sugar levels. However,
      very little is known about how exercise and/or weight loss improves liver function in people
      with type 2 diabetes.

      Hypothesis 1: Improved hepatic insulin sensitivity, as a result of exercise training will
      increase the amount of glucose from an oral load that is taken up by the liver in subjects
      with DM.

      Hypothesis 2: Increases in hepatic insulin sensitivity as a result of exercise will cause
      reductions in EGP during the fasted state, and will improve the suppression of EGP seen in
      response to hyperinsulinemia.
    


Intervention name(s): Aerobic exercise
Intervention type(s): Behavioral
Intervention description(s): 12 weeks of aerobic exercise with weight maintenance
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Obesity; Type 2 diabetes; Liver
Corticosteroid And Ozone Injection In Patıents With Carpal Tunnel Syndrome
Condition: Carpal Tunnel Syndrome
MeSH terms: Carpal Tunnel Syndrome; Syndrome
Study type: Interventional

Summary: 
      There are a limited number of studies on the use of ozone in CTS.The aim of this clinical
      study is to compare the effectiveness of corticosteroid injections and ozone injections added
      to splint and exercise therapy in mild-moderate CTS patients..

      106 patients included in the study were randomized and divided into three groups. During the
      follow-up, a total of 90 patients, 30 patients in each group, completed the study.
    

Detailed description: 
      106 patients included in the study were randomized and divided into three groups.

      During the follow-up, a total of 90 patients, 30 patients in each group, completed the study.

      Neutral hand-wrist rest splint and tendon-nerve gliding exercises were given to 30 patients
      included in the control group.

      In addition to the treatment given to the first group, 40 mg (1 ml) triamcinolone acetonide
      was injected under USG guidance to 30 patients included in the corticosteroid group.

      In addition to splint and exercise therapy, 3 cc ozone (O2-O3), 10 micrograms were injected
      under USG guidance to 30 patients in the ozone group.

      Patients in all three groups were evaluated at the beginning of treatment, 6 weeks and 3
      months after treatment.

      Evaluation methods include provocative tests (Tinnel, Phallen, Flick tests), visual analogue
      scale (VAS) numbness day/night and VAS pain scores, sensory tests (two-point discrimination
      and Semmes Weinstein monofilament test (SWMT)), hand and finger grip strengths. measurement,
      Boston carpal tunnel syndrome questionnaire (BCTA), median nerve cross-sectional area (MSCA)
      measurement with USG and electrophysiological parameters were used.
    

Intervention name(s): splint and exercise and advices; Triamsinolon Asetonid ozone; ozone
Intervention type(s): Other; Other; Other
Intervention description(s): A hand-wrist support splint and tendon shifting exercises were applied to the upper extremity of the affected side.; 40 mg (1 ml) of triamcinolone acetonide was injected to the median nerve's around at wrist level under ultrasound guidance.; In addition to the treatment and recommendations given to the first group, the affected side was injected with ultrasound-guided 3 cc ozone (O2-O3) into the wrist with a concentration of 10 micrograms/ml.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: ozone injection; corticosteroid injection; carpal tunnel sendromu; ultrasound guided injection
Improved Management and in-Hospital Mortality
Condition: Mortality; Malaria
MeSH terms: Malaria
Study type: Interventional

Summary: 
      The study intend to evaluate whether the use of standardised malaria case management protocol
      plus financial incentives added to the availability of free drugs reduce the case-fatality at
      the paediatric ward.
    

Detailed description: 
      Mortality at the national paediatric ward in Guinea-Bissau is very high. During a civil war
      in 1998/1999 the hospital case fatality (CF) decreased by more than 40%, increasing again
      after the the war. This was attributed to the available free drugs from the humanitarian aid
      and food incentives to the personnel. Free emergency kits for treatment of severe malaria was
      introduced, however the CF did not decline. Therefore, the ward was split into two groups of
      rooms: intervention and control. All the staff of the ward was trained in the use of a
      standardised guideline for treatment of severe malaria and randomly assigned to one of the
      groups. All children hospitalised for malaria received the drug emergency kits. The only
      difference in the intervention group were the small financial incentives and supervision for
      strict adherence to the guidelines procedures.
    

Intervention name(s): Guideline adherence and financial incentive
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: malaria; mortality; hospital; incentive; personnel; paediatric
Prothrombin Time Predicts Steroid Response in Severe Alcoholic Hepatitis.
Condition: Alcoholic Hepatitis
MeSH terms: Hepatitis A; Hepatitis; Hepatitis, Alcoholic
Study type: Observational

Summary: 
      Alcoholic hepatitis (AH) is the most severe form of acute alcohol-related liver disease.
      Maddrey's discriminant function (mDF) >32 defines the severe form of AH, which is associated
      with a high mortality. Corticosteroid therapy (CS) represents the main medical treatment that
      may reduce short-term mortality. Lille score at day 7 assesses the therapeutic response to
      steroid therapy. At present, no parameters able to predict the response to steroid therapy
      have been highlighted. The mDF depends mainly on prothrombin time (PT). Aim of the present
      study was to evaluate if the PT value could predict the response to CS in severe AH (sAH).
    


Intervention name(s): prothrombin time
Intervention type(s): Diagnostic Test
Intervention description(s): Prothrombin time at value at diagnosis was used to assess the presence of a correlation with Lille score at day 7 and therefore wether it could predict response to medical treatment.
Intervention MeSH terms: Thrombin
Observational model: Case-Only
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Patients admitted to the Internal Medicine and Alcohol Related Diseases Unit of a teaching
        hospital with a clinical diagnosis of severe alcoholic hepatitis
      
Keywords: early liver transplantation; alcohol; cirrhosis; corticosteroid therapy; Maddrey's discriminant function; Lille score; prothrombin time; Alcohol Use Disorder; steroid response
Evaluation of Therapeutic Video Games for Pre-school Children With Acute Lymphoblastic Leukemia
Condition: Childhood Lymphoblastic Lymphoma
MeSH terms: Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Lymphoid
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the effectiveness of therapeutic video game.
    

Detailed description: 
      Children cancer was the third-ranked causes of children's death. During the long treatment
      courses, children are always forced to accept lots of drug therapy and invasive procedures
      without understanding the medical purpose. Due to the immature cognition, always lead to
      anxiety in childhood cancer patients. Our team developed a mobile technology platform based
      therapeutic video game (TVG) for preschoolers with acute lymphoblastic leukemia (ALL) in
      early 2018. Then three clinical experts were invited to validate TVG and had high
      appropriateness consensus. Then the pilot study was conducted in one medical center in Taipei
      and 10 preschoolers with ALL had been randomly signed in two groups-5 to intervention group
      (6 weeks game intervention) and 5 to control group (regular care). The preliminary results
      showed that crying scale and resisting behavior were no significance between two groups in
      the initial period (p=.663), but the intervention group showed lower crying grades and less
      resisting behavior than the control group in the final period (p=.028). The limitation of
      this pilot research was small sample size and short intervention time. Therefore, the purpose
      of this study is to increase the sample size and intervention time to evaluate the
      effectiveness of our TVG.

      Methods: A total of 68 fresh ALL preschool children will be randomized divided equally into
      intervention group and control group. Only intervention group
    

Intervention name(s): TVG
Intervention type(s): Other
Intervention description(s): Therapeutic video game
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Investigator)
Primary purpose: Supportive Care
Keywords: Acute lymphoblastic leukemia; Therapeutic Video games; Childhood cancer; Preschoolers; Anxiety; Resisting behavior
A Safety Study to Assess the Effects of Therapeutic and Supratherapeutic Exenatide Concentrations on QT Interval in Healthy Subjects
Condition: Healthy Subjects
Study type: Interventional
Phase: Phase 1

Summary: 
      Compare the effect of exenatide (therapeutic and supratherapeutic concentrations),
      moxifloxacin and placebo on the QT interval.
    


Intervention name(s): Exenatide; Moxifloxacin; Placebo comparator
Intervention type(s): Drug; Drug; Drug
Intervention description(s): IV Exenatide (therapeutic and supratherapeutic concentrations); Oral Moxifloxacin (400 mg); IV Placebo (matching volume of placebo)
Intervention MeSH terms: Exenatide; Moxifloxacin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Keywords: Diabetes; exenatide; Amylin; Lilly; QT interval
Laryngeal Mask Airway Facilitates a Safe and Smooth Emergence From Anesthesia in Patients Undergoing Craniotomy
Condition: Complications, Pulmonary
Study type: Interventional

Summary: 
      Stabilizing hemodynamic and reducing pulmonary complications during extubation with switching
      endotracheal tube to laryngeal mask in craniotomies
    

Detailed description: 
      recruit ASA: 1-3, 20-65 years old undergoing neurosurgery under general anesthesia Excluded
      1.Decline to participated 2.Difficult airway 3.Body Mass Index >30 4. Pregnant woman
      5.Nothing Per Os <8hrs(case number:80).

      General anesthesia Induction: 0.15-0.2 mg/kg cisatracurium or 0.6-1.2mg rocuronium , 1.5-2
      mg/kg propofol, 1-2 mcg/kg Fentanyl. Endotracheal tube 6.5-7.5mm. Maintenance with
      sevoflurane 2- 3% FiO2:100%. Optimal muscle tension monitor. When surgery done, sevoflurane
      at 2.63-2.97%

      Then randomly assigned two group Anesthesia group(control group) : Removed endotracheal tube
      at sevoflurane at 2-3% Switching group (intervention group): Intervention with endotracheal
      tube to laryngeal mask, and removing laryngeal mask at sevoflurane: 0.4MAC
    

Intervention name(s): Ambu® AuraOnce™ Disposable Laryngeal Mask
Intervention type(s): Device
Intervention description(s): Switching endotracheal tube to laryngeal mask at sevoflurane 2.63-2.97%, Removing endotracheal tube when spontaneously generating tidal volume of >4ml/kg, EtCO2<45mmHg, Train of four ratio >70-90%.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Extubation; Laryngeal mask; Craniotomies
Study to Investigate the Absolute Bioavailability of a Single Oral Dose of Ponesimod in Healthy Male Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This study consists of a single-dose pilot phase and a randomized, two-way crossover,
      single-dose main phase.The aim of this study is to evaluate the absolute bioavailability of
      the oral formulation (tablet) of ponesimod compared to an intravenous (i.v.) ponesimod
      formulation. Three subjects will be included in the pilot phase and 12 subjects in the main
      crossover phase.
    


Intervention name(s): Ponesimod 5mg i.v.; Ponesimod i.v.; Ponesimod 10 mg tablet
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Dose and infusion rate will be adjusted according to the results of the pilot phase
Intervention MeSH terms: Ponesimod
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: Ponesimod; Bioavailability; Pharmacokinetics; Safety
Comparison of Atomoxetine Versus Placebo in Children With Attention-Deficit/Hyperactivity Disorder (ADHD)
Condition: Attention Deficit Hyperactivity Disorder
MeSH terms: Hyperkinesis; Attention Deficit Disorder with Hyperactivity
Study type: Interventional
Phase: Phase 4

Summary: 
      This is a two-arm, parallel, randomized, double-blind, placebo-controlled Phase 4 multicenter
      trial to compare the whole day efficacy of atomoxetine versus placebo in children aged 6
      through 12 years with Attention-Deficit/Hyperactivity Disorder (ADHD) treated in an
      inpatient, day-patient and outpatient setting in Germany. Core symptoms will be measured
      during once or bi-weekly visits, three times per visit-day, by a computer based Continuous
      Performance Test. Following an initial 3-28-day screening and washout phase, patients will be
      assigned to double-blind treatment with atomoxetine or placebo. In the verum arm, a one-week
      atomoxetine treatment period with the 0.5 mg/kg per day lead-in dose will be succeeded by a 7
      week period at the target dose of 1.2 mg/kg per day.
    


Intervention name(s): Atomoxetine; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): A one-week atomoxetine treatment period with the 0.5 mg/kg per day lead-in dose will be succeeded by a 7 week period at the target dose of 1.2 mg/kg per day. 3 capsules of study medication have to be taken once daily in the morning, with or without food.; 3 capsules of placebo have to be taken once daily in the morning, with or without food.
Other intervention name(s): LY139603
Intervention MeSH terms: Atomoxetine Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
The Acute Effect of Beetroot Juice in Normal and Hypertensive Subjects
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      Inorganic nitrate can be converted to nitrite and thence nitric oxide in humans. Nitric oxide
      is normally produced by the inner lining of blood vessels and helps keep blood vessels open
      and therefore blood pressure lower. In subjects with high blood pressure, the inner lining of
      the blood vessels does not function adequately. The investigators wish to investigate whether
      elevating systemic levels of inorganic nitrate (through provision of dietary nitrate-rich
      vegetables) can elevate levels of nitrate/nitrite in hypertensive subjects, and whether this
      has a beneficial effect on blood pressure.
    


Intervention name(s): Beetroot juice; Water
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 250ml once of beetroot juice; 250ml once of low-nitrate mineral water
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Keywords: Nitrate; Nitrite; Vegetable; Aortic stiffness
Protein Supplementation and Skeletal Muscle Healing Process
Condition: Skeletal Muscle Damage; Exercise-induced Aseptic Inflammation; Skeletal Muscle Performance; Intracellular Signaling in Skeletal Muscle; Proteasome Activation
MeSH terms: Inflammation
Study type: Interventional

Summary: 
      In this study the investigators utilized protein supplementation over an 8-day period
      following eccentric exercise-induced muscle damage in order to test the initial hypotheses :
      i) protein supplementation after exercise-induced muscle injury affects exercise-induced
      aseptic inflammation and muscle performance.
    

Detailed description: 
      The objective was to examine weather protein supplementation is able to affect the
      inflammatory response as well as recovery of muscle performance following an intense
      eccentric exercise protocol. In a double-blind, counterbalanced design, 14 men received
      either Placebo (PLA) or milk protein isolate (PRO) for 8 consecutive days following a single
      bout of exercise (300 eccentric contractions at 30 deg/sec). In both conditions, performance
      was assessed at baseline, immediately post-exercise, 2h post-exercise and daily for 8
      consecutive days. Blood samples were collected at baseline, 2h post-exercise and daily for
      the remaining 8 days. Muscle biopsies from vastus lateralis were collected at baseline as
      well as at day 2 and day 8 of the post-exercise period.
    

Intervention name(s): Milk protein isolate; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Milk protein isolate in a powder form consisted of 80% casein and 20% whey protein. 20g were diluted into 500 ml water.
Placebo consisted of 365 ml water, 125 ml sugar-free cordial and 2g of low-calorie glucose/dextrose powder.; 500 mL drink that contained water (375 mL), sugar-free cordial (125 mL) and 2 g of low-calorie glucose/dextrose powder.
Intervention MeSH terms: Caseins
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Ambroxol Lozenges 20mg in Relieving the Pain of Sore Throat in Adolescent Patients With Acute Viral Pharyngitis
Condition: Pharyngitis
MeSH terms: Pharyngitis
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this trial is to investigate efficacy and tolerability of lozenges containing
      20mg am broxol hydrochloride relative to placebo in relieving pain of sore throat in
      adolescent patients suf fering from acute viral pharyngitis. The primary endpoint is the
      time-weighted average of the pain intensity difference from pre-dose bas eline over the first
      3 hours after the first lozenge expressed as a ratio of the pre-dose baseline ( SPIDnorm).
    

Detailed description: 
      The purpose of this trial is to investigate efficacy and tolerability of lozenges containing
      20mg am broxol hydrochloride relative to placebo in relieving pain of sore throat in
      adolescent patients suf fering from acute viral pharyngitis. The pain intensity will be
      assessed by the patient on a 6-point rating scale before taking the first lozenge and 30, 60,
      120 and 180 minutes thereafter. The patient enters the rating in the patient's diary.

      Study Hypothesis:

      It will be tested whether a statistically significant difference exists in the S PIDnorm
      after the intake of the 1st lozenge between the group treated with ambro xol lozenges and the
      group treated with placebo lozenges.

      Comparison(s):

      Placebo comparison
    

Intervention name(s): Ambroxol Lozenge
Intervention type(s): Drug
Intervention MeSH terms: Ambroxol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment