bioihbjkbjnl/mcl2 huggingface dataset:
Hallux Valgus Manual Therapy Based on Global Postural Reeducation.
Condition: Hallux Valgus; Hallux Deformity; Foot Deformities
MeSH terms: Hallux Valgus; Bunion; Foot Deformities; Foot Deformities, Congenital; Congenital Abnormalities
Study type: Interventional

Summary: 
      Manual approach of Hallux Valgus with global postural reeducation.
    

Detailed description: 
      Hallux Abducto Valgus is a frequent pathology with a prevalence of 30% in women and 13% in
      men. The tendency is to increase with age.

      Usually, the elected treatment is surgery, as the conservative orthopedic methods are used at
      the early stages of the pathology. Global Postural Re-Education is a manual therapy treatment
      method through which we can treat lots of pathologies. Some investigations demonstrate
      Postural Re-Education is effective for the treatment of temporomandibular disorders, urinary
      incontinence, and spine disorders, but there is no scientific evidence that defends the
      improvement of the symptoms and correction of the angle of the Hallux Abducto Valgus using
      Postural Re-Education.
    

Intervention name(s): Global postural reeducation
Intervention type(s): Other
Intervention description(s): It consisted of Global Postural Re-Education sessions divided into 3 sessions and performed with a frequency of 1 per week for 3 weeks. The sessions were performed individually, with an approximate duration of 40 minutes and all of them were assessed by the same physiotherapist.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A single-blind randomized controlled trial.
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Mixed Chimera Allogeneic Transplantation From Matched Unrelated Donors For The Treatment Of Multiple Myeloma
Condition: Multiple Myeloma
MeSH terms: Multiple Myeloma; Neoplasms, Plasma Cell
Study type: Interventional

Summary: 
      The purpose of the study is to determine the toxicity and feasibility of non-myeloablative
      allogeneic hematopoietic cell transplants for multiple myeloma from unrelated donors.
    

Detailed description: 
      The primary objective of the protocol is to evaluate the toxicity and tolerability of this
      mixed chimerism matched unrelated donor allogeneic transplant approach for patients with
      multiple myeloma. Response, toxicity, survival and graft-versus-host disease will be
      evaluated.
    

Intervention name(s): Autologous followed by non-myeloablative allogeneic transplantation
Intervention type(s): Procedure
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Bitter Chocolate or Orange Juice for Non-reactive Non-stress Test (NST) Patterns
Condition: Nonreassuring Fetal Status
MeSH terms: Fetal Distress
Study type: Interventional

Summary: 
      There are multiple factors affecting the variability and acceleration pattern of fetal heart
      rate (FHR) pattern. However, fetal activity is considered as the main determinant. Any factor
      decreasing fetal activity causes a decrease in FHR variability. Fetal activity may be
      stimulated by manual manipulation, sound, light, change in maternal position and maternal
      ingestion of glucose. Among those, ingestion of any kind of food or juice is most frequently
      practiced in outpatient settings. This is not only medical but also a social routine. In this
      study the investigators have chosen the two most popular so-called 'fetal accelerators',
      chocolate and orange juice against no intervention and tried to find any usefulness of these
      on non-reactive NST patterns.
    


Intervention name(s): Bitter chocolate; Orange juice
Intervention type(s): Dietary Supplement; Dietary Supplement
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Keywords: non-stress test
Impact of Time to Coronary Angiography on Survival for NSTEMI
Condition: Non ST-elevation Myocardial Infarction
MeSH terms: Myocardial Infarction; Non-ST Elevated Myocardial Infarction; Infarction
Study type: Observational [Patient Registry]

Summary: 
      This study aims to investigate the extent to which the time to angiography impacts on
      survival in patients hospitalised with NSTEMI.
    

Detailed description: 
      The use of an invasive strategy for the management of NSTEMI according to estimated risk of 6
      month mortality is recommended by international guidelines. NSTEMI appropriate for coronary
      angiography (and percutaneous intervention) have better outcomes compare with NSTEMI who are
      medically managed. Whilst the national and international guidelines recommend that the timing
      of (in-hospital) coronary angiography (<24, 24-72, 72-96 and <96 hours) is based upon
      estimated clinical risk (using the GRACE risk score) there is scientific and clinical
      uncertainty as to the incremental benefit that more urgent invasive treatments strategies
      have over and above that of delayed strategies. Moreover, the investigators recent research
      has shown that in the UK, may NSTEMI (eligible) for coronary angiography fail to achieve care
      according to the recommended time thresholds, and this is associated with potentially
      avoidable premature death.

      This study aims to investigate the extent to which the time to angiography impacts on
      survival in patients hospitalised with NSTEMI. It will characterise patients according to
      their estimated risk of death, their time to angiography, and associated outcomes. The
      investigators anticipate that this observational study will provide Level B evidence for the
      benefits of the timing of an invasive strategy according to the GRACE risk score. The
      investigators are aware that the NICE guidelines for the management of acute chest pain are
      to be updated in 2016.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The study population comprises 725,860 patients hospitalised for acute myocardial
        infarction and entered into the Myocardial Ischaemia National Audit Project (MINAP)
        database between April 2004 and March 2013.
fMRI of Flight of Ideas in Bipolar Disorder
Condition: Bipolar Disorder
MeSH terms: Bipolar Disorder
Study type: Interventional

Summary: 
      Bipolar disorder is a mental disease characterized by mood dysregulation and arises from
      manic, depressive or mixed episodes. The observations of the patient's speech and language
      behaviour due to flight of ideas or loss of goal probably result from an underlying
      disturbance in semantic networks dealing with semantic associations. The aim of our study
      will be to have a better comprehension of thought disorders in bipolar disorder by cognitive
      exploration of semantic processing.
    

Detailed description: 
      Bipolar disorder is a mental disease characterized by mood dysregulation and arises from
      manic, depressive or mixed episodes. During these episodes, formal thought disorders are
      observed, associated to emotional perturbation, behaviour troubles and some psychotic
      symptoms. During mania, the type of thought disorders observed are derailment, flight of
      ideas, with an increase in the amount of spontaneous speech and loss of goal. These
      observations of the patient's speech and language behaviour probably result from an
      underlying disturbance in semantic networks dealing with semantic associations. These
      networks have been studied extensively in schizophrenia but remain unknown in bipolar
      disorder. In this context, the aim of our study will be to have a better comprehension of
      formal thought disorders in bipolar disorder by cognitive exploration of semantic activation
      and inhibition.
    

Intervention name(s): Functional Magnetic Resonance Imaging
Intervention type(s): Other
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Dermacyd Infantile (Lactic Acid)- Compatibility.
Condition: Hygiene
Study type: Interventional
Phase: Phase 4

Summary: 
      Primary Objective:

      To demonstrate the absence of irritation potential (primary dermic irritability and cumulated
      dermic irritability) and allergic potential (sensibilization) of the product Dermacyd
      Infantile.
    


Intervention name(s): LACTIC ACID(ND)
Intervention type(s): Drug
Intervention description(s): Dermacyd Infantile (Lactic Acid)
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Probiotic Intervention for Acute Stress
Condition: Stress
Study type: Interventional

Summary: 
      Efficacy of probiotics on acute stress
    


Intervention name(s): Probiotic supplement; Placebo supplement
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Capsule containing freeze dried probiotic bacteria together with maize starch; Capsule containing maize starch
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Effects of CHONDRON (Autologous Chondrocytes) With Ankle Cartilage Defect
Condition: Articular Cartilage Defects of Ankle Joint
MeSH terms: Cartilage Diseases
Study type: Interventional
Phase: Phase 3

Summary: 
      An open clinical trial transplanting CHONDRON (autologous chondrocytes) to ankle cartilage
      defect patients who are appropriate for the trial, and evaluating the validity and safety for
      12 months.
    

Detailed description: 
      This clinical trial was designed to observe effects of CHONDRON (autologous chondrocytes) for
      12 months in patients with ankle cartilage defects. In this clinical trial, 30 subjects were
      screened- 4 were excluded half way and 26 finished the trial. Full-thickness articular
      cartilage specimen was obtained from sites that do not have direct articulation within the
      ankle joint(anterior talus, anterior process of calcaneus, calcaneocuboid joint area.)
      Gel-type CHONDRON (Fibrin mixed Autologous chondrocytes) was transplanted at the defects.
      Evaluation variables were AOFAS, 100 mm VAS, HANNOVER score, self-assessment of improvement
      by the patient, MRI and arthroscopy.
    

Intervention name(s): Chondron(autologous chondrocyte) Implantation
Intervention type(s): Procedure
Intervention description(s): Test drug: Chondron (more than 12 million chondrocytes in 0.4ml, i.e. 1 vial)
Directions and dosage:
Suspend the cells in the vial sufficiently, and implant them in the defective part, making sure that sufficient amounts are injected.
*30 subjects participated in this open clinical trial. Those who agreed to participate voluntarily went through screening to confirm the appropriateness for the clinical trial, and then received Gel type CHONDRON (fibrin mixed autologous chondrocytes) transplantation.
Other intervention name(s): Chondron
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: articular cartilage defects; ACI; ankle joint; chondron
Safety Study of Sodium Divalproate in Bipolar Disorder in Adolescents
Condition: Bipolar Disorder
MeSH terms: Bipolar Disorder
Study type: Interventional
Phase: Phase 3

Summary: 
      - Main objective: To evaluate the clinical and physiological tolerance of sodium divalproate
      in manic, mixed or hypomanic episodes of bipolar disorder in adolescents treated for 6
      months.

      - Secondary objective: To evaluate the efficacy of sodium divalproate in improving manic,
      mixed or hypomanic symptoms.
    


Intervention name(s): SODIUM DIVALPROATE
Intervention type(s): Drug
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Skeletal and Cognitive Effects of Nutrition From Eggs
Condition: Bone Health; Cognitive Health
Study type: Interventional

Summary: 
      This project is the first egg feeding randomized controlled trial (RCT) in children. The goal
      of this RCT is to determine if eating formulated whole egg products for 9 months improves
      bone health and cognitive function in children ages 9-13 years more than children consuming
      products made of milk powder or gelatin.
    

Detailed description: 
      This 9-month randomized controlled trial is an egg product intervention in otherwise healthy,
      9-13 year-old children in the early stages of puberty (N=120). It will assess changes in bone
      material and geometric properties using dual energy x-ray absorptiometry (DXA) and peripheral
      quantitative computed tomography (pQCT). Cognitive function will be measured by the National
      Institute of Health's Toolbox. Participants will be randomized to one of 3 treatment (i.e.,
      whole egg powder, whole milk powder, or gelatin) groups, and instructed to consume the food
      projects 10 times/week in substitute for other similar food products in their diet for
      9-months. Five product choices per treatment group will be provided. The food products were
      developed specifically for this study by the University of Georgia's Food Product Innovation
      and Commercialization center and consumer tested. Additionally, these food products will be
      micro-tested prior to distribution to participants. We hypothesize that children consuming
      whole egg products will have enhanced bone outcomes and cognitive abilities in comparison to
      those consuming whole milk powder or gelatin.
    

Intervention name(s): Whole egg powder; Whole milk powder; Gelatin food product
Intervention type(s): Other; Other; Other
Intervention description(s): Participants will receive waffles, pancakes, brownies, ice cream and mac and cheese made with whole egg powder. The food projects were developed specifically for this study by the University of Georgia's Food Product Innovation and Commercialization Center and consumer tested by children within the study age range prior to intervention enrollment.; Participants will receive waffles, pancakes, brownies, ice cream and mac and cheese made with whole milk powder. The food projects were developed specifically for this study by the University of Georgia's Food Product Innovation and Commercialization Center and consumer tested by children within the study age range prior to intervention enrollment.; Participants will receive waffles, pancakes, brownies, ice cream and mac and cheese made with gelatin. The food projects were developed specifically for this study by the University of Georgia's Food Product Innovation and Commercialization Center and consumer tested by children within the study age range prior to intervention enrollment.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Other
Keywords: Bone; Cognition; Egg; Protein
Effect of Liraglutide vs CPAP on Cardiometabolic Outcomes in Obstructive Sleep Apnea
Condition: Sleep Apnea, Obstructive
MeSH terms: Apnea; Sleep Apnea Syndromes; Sleep Apnea, Obstructive
Study type: Interventional

Summary: 
      This is an explorative, proof-of-concept study exploring the potential therapeutic role of a
      Liraglutide-based weight loss regimen versus standard CPAP or the combination of both on
      metabolic parameters, blood pressure, endothelial function, coronary artery calcification,
      vascular inflammation and apnea/hypopnea index in non-diabetic patients with moderate to
      severe obstructive sleep apnea
    


Intervention name(s): Liraglutide (Saxenda) 6Mg/Ml Inj Pen 3Ml; Continuous positive airway pressure treatment; Liraglutide and CPAP
Intervention type(s): Drug; Device; Combination Product
Intervention description(s): GLP-1 analogue treatment in combination with advice on diet and physical exercise; Gold standard treatment for obstructive sleep apnea; Combination of both treatments
Intervention MeSH terms: Liraglutide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Liraglutide; Continuous positive airway pressure; Insulin resistance; Vascular inflammation
CQDSA in Evaluation of Prognosis After EVAR
Condition: Endoleak; Aortic Aneurysm, Abdominal
MeSH terms: Aneurysm; Aortic Aneurysm; Aortic Aneurysm, Abdominal; Endoleak
Study type: Observational

Summary: 
      Re-hospitalization or re-intervention is sometimes necessary to treat type I and type III
      endoleaks after EVAR for its persistent increasing of pressure in aneurysm lumen. Color-coded
      quantitative digital subtraction angiography (CQDSA) provides an easy and quick way to
      post-process the traditional digital subtraction angiography (DSA) which converts the peak
      time of the maximal contrast medium intensity into a single polychromatic image. With the
      help of CQDSA, a quantitative evaluation of the endoleak hemodynamics and a risk analysis of
      the type I or type III endoleak could be performed during the EVAR procedure. This approach
      may offer an objective assessment of the needs for immediate re-intervention, conservative
      therapy or treatment endpoint in the future.
    

Detailed description: 
      Intra-procedural DSA series are transferred to a research workstation to generate the
      color-coded images and make quantitative measurements. Region of interest (ROI) measurements
      are performed equivalently in the endoleak and the aorta after the image generation. There
      are three kinds of ROIs including a small circle area with the shortest time to peak, a
      circle area with peak contrast intensity and the whole endoleak area. The ROI and a reference
      at the same latitude within the aorta are selected to undergo measurement which reflected the
      endoleak hemodynamics of the endoleak to the utmost extent.

      The following parameters will be acquired through the CQDSA for analysis.

        1. Time-versus-ROI contrast intensity graph. The graph contains one endoleak ROI flow curve
           and one reference aortic flow curve (Ref). The x-axis shows time from 0 second to the
           maximum frame time of the image. The y-axis shows the sum of pixel intensities, namely
           total contrast, representing the contrast concentration within the ROI.

        2. ROI Peak/Ref Peak. It is the ratio of intensity peak between the endoleak and the
           reference in the aorta.

        3. ROI TTP (Time to peak). Peak time of ROI in the vicinity of endoleak entry.

        4. ROI AUC/Ref AUC. Area under curve (AUC) is calculated through Time-versus-ROI contrast
           intensity graph. The parameter here is the ratio of ROI AUC in endoleak to the
           reference.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients who present type I endoleak after EVAR for AAA.
      
Keywords: endoleak; EVAR; AAA; CQDSA
A Pilot Study to Evaluate the Effects of Subcutaneously Administered Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor in Pediatric HIV-Infected Patients With Neutropenia Secondary to Azidothymidine
Condition: HIV Infections; Cytopenias
MeSH terms: Neutropenia
Study type: Interventional

Summary: 
      To assess the safety and efficacy of subcutaneous sargramostim ( granulocyte-macrophage
      colony-stimulating factor; GM-CSF ) in increasing and maintaining the granulocyte count in
      HIV-infected children who have developed granulocytopenia as a result of continuous
      intravenous ( CIV ) zidovudine ( AZT ). To assess the short-term and long-term effects of
      concomitant GM-CSF on other hematologic parameters. To assess the potential therapeutic
      benefit of concomitant GM-CSF and AZT on the natural history of HIV infection and associated
      infectious complications.
    


Intervention name(s): Zidovudine; Sargramostim
Intervention type(s): Drug; Drug
Intervention MeSH terms: Zidovudine; Sargramostim
Primary purpose: Treatment
Keywords: Pilot Projects; Neutropenia; Granulocyte-Macrophage Colony-Stimulating Factor; Acquired Immunodeficiency Syndrome; Zidovudine
Effects of Right Lower Limb Orthopedic Immobilization on Braking Function
Condition: Automobile Driving With an Aircast Walker; Automobile Driving With a Walking Cast
Study type: Interventional

Summary: 
      Research on the implications of orthopedic injury and surgery on automobile driving ability
      has been limited. Only a handful of orthopedic issues have been studied to date, especially
      the safe postoperative resumption of driving. However, effects of orthopedic immobilizations
      of the lower right limb on fitness to drive are largely unknown, and the physician is left
      with little guidance. Only one study (Tremblay et al. 2009) have looked at the impact of
      wearing such devices on braking performances. The results have shown a statistically
      significant increase of braking times while wearing a removable Aircast walker and a walking
      cast in healthy subjects under simulated driving conditions. Despite this, the study have not
      demonstrated that driving with orthopedic immobilization is dangerous since the increase in
      braking times were minimal. Limitations of this study include the important fact that driving
      simulation is not real-time driving. In order to assess the validity of the driving simulator
      used in this study, a similar experimental study during real-time driving was thus devised.
    


Intervention name(s): Driving with an Aircast Walker; Driving with a walking cast; Driving with a running shoe
Intervention type(s): Procedure; Procedure; Procedure
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Automobile Driving; Fracture Fixation/instrumentation; Lower Extremity; Orthopedic Fixation Devices; Orthopedic Procedures; Reaction Time; Task Performance and Analysis; Time Factors
Safety Study of Apixaban in Recent Acute Coronary Syndrome
Condition: Acute Coronary Syndrome (ACS)
MeSH terms: Acute Coronary Syndrome; Syndrome
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this clinical research study is to determine whether apixaban will be safe in
      people who have recently had unstable angina or a heart attack.
    


Intervention name(s): Apixaban; Apixaban; Placebo; Apixaban
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Tablets, Oral, 2.5 mg, twice daily, 26 weeks; Tablets, Oral, 10 mg, once daily, 26 weeks; Tablets, Oral, 0, twice daily, 26 weeks; Tablets, Oral 10 mg, twice daily, 26 weeks
Intervention MeSH terms: Apixaban
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention