The Internet Therapy for Depression Trial
Condition: Chronic Pain; Major Depressive Disorder
MeSH terms: Chronic Pain; Depression; Depressive Disorder; Depressive Disorder, Major
Study type: Interventional

Summary: 
      The objective of this trial is to collect data on the feasibility, acceptability, and
      preliminary effectiveness of internet delivered Cognitive Beaviour Therapy (iCBT) and
      Acceptance and Commitment Therapy (iACT) interventions tailored towards the treatment of
      depression and chronic pain using a doubly-randomized, attention-controlled, non-blinded,
      patient-preference design.
    

Detailed description: 
      The primary objective is to collect data on the feasibility, acceptability, and preliminary
      effectiveness of internet delivered Cognitive Beaviour Therapy (iCBT) and Acceptance and
      Commitment Therapy (iACT) on depressed mood among individuals with chronic pain relative to
      attention control (AC). The secondary objectives are to evaluate the efficacy of iCBT and
      iACT on clinically relevant outcomes endorsed by the Initiative on Methods, Measurement, and
      Pain Assessment in Clinical Trials (IMMPACT). Adults with chronic non-cancer pain and major
      depression will be randomized to receive iACT, iCBT, or AC. The interventions comprise 7
      weekly online modules available through Therapist Assisted Online (TAO). Patients will be
      contacted weekly by a member of the study team who will be acting as their personalized
      "online therapy coach."
    

Intervention name(s): internet delivered cognitive behavioural therapy (iCBT); online delivered acceptance and commitment therapy (iACT); Attention Control (AC)
Intervention type(s): Behavioral; Behavioral; Other
Intervention description(s): The intervention comprises 7 weekly online modules available through Therapist Assisted Online (TAO), including: 1) psychoeducation about chronic pain and depression; 2) thoughts and feelings; 3) understanding stress and relaxation; 4) unhealthy and healthy thoughts; 5) layers of thinking; 6) core beliefs; and 7) relationship, lifestyle, problem solving, and relapse prevention. Online content is supplemented with weekly coaching sessions performed via video-conference with doctoral students of Clinical Psychology.; The intervention comprises 7 weekly online modules available through Therapist Assisted Online (TAO), including: 1) psychoeducation about chronic pain and depression; 2) introduction to ACT; 3) cognitive fusion and defusion; 4) thinking mind versus observing mind & acceptance; 5) mindfulness; 6) values; and 7) taking action. Online content is supplemented with weekly coaching sessions performed via video-conference with doctoral students of Clinical Psychology.; 1-module of psychoeducation about chronic pain and major depression. Weekly contact to complete measures of symptomatology and well-being.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Doubly-randomized, patient-preference trial with two active study interventions and one control.
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Chronic non-cancer pain; Major depression; Internet therapies; Cognitive behaviour therapy; Acceptance and commitment therapy