T2* in Transfusion Dependant Anemia, MI, LVF, Normal Patients
Condition: Thalassemia
MeSH terms: Thalassemia
Study type: Observational

Summary: 
      The purpose of this study is to provide accurate prognostic data linking cardiac
      complications to myocardial T2* values (A measure of iron levels in the heart using MRI)in
      patients predisposed to heart iron overload.
    

Detailed description: 
      Key Definitions Myocardial siderosis - Iron deposition that occurs in the heart, usually in
      relation to recurrent blood transfusions and red cell breakdown.

      Thalassaemia - A hereditary form of anaemia leading to recurrent blood transfusions and iron
      overload.

      Cardiomyopathy - Disease of the heart leading to heart failure. In the case of cardiac
      siderosis it is entirely reversible.

      Chelation - Drug used to remove iron from the heart T2* CMR - Cardiac Magnetic Resonance
      Imaging. A specialised scan that uses a large magnet to image the heart. As iron has magnetic
      properties we can use this scan to determine the amount of iron within the heart. T2* is a
      value that relates to the level of iron loading in the heart. A T2* of less than 10 relates
      to severe heart iron loading, a T2* of 10-20 relates to mild/moderate heart iron loading and
      a T2* of greater than 20 relates to no significant iron loading in the heart.

      Heart failure - Disease in which the myocardium (heart muscle) weakens and can not pump blood
      efficiently. Fluid accumulates in the lungs, hands, ankles, or other parts of the body. The
      mortality from heart failure is very high.

      Heterozygotes - An individual with one normal and one abnormal thalassaemia gene. They are
      carriers of the thalassaemia gene with milder clinical manifestations.

      Homozygotes - An individual who has inherited both abnormal thalassaemia genes producing a
      more severe form of the disease.

      Question Response Although a rare disease in the UK, thalassaemia is the commonest genetic
      disorder worldwide, with approximately 94 million heterozygotes for beta thalassaemia and
      60,000 homozygotes born each year.

      In the United Kingdom, despite relatively easy access to healthcare, approximately 50% of
      patients with thalassaemia major die before reaching the age of thirty five. Of those deaths,
      over 60% are a result of heart failure. The cardiomyopathy is reversible if chelation is
      commenced early but diagnosis is often delayed due to the late onset of symptoms and
      measurable LV dysfunction.

      This study will provide strong evidence that a myocardial T2* <10ms represents a high risk of
      developing cardiac complications. Derived risk ratios will provide sound guidance as to when
      life saving chelation is required.

      A database will be produced containing clinical data and T2* values on 665 thalassaemia
      patients from 1998-2006.

      A diagnosis of heart failure will be made if the patient has had an ejection fraction of less
      than 55% (measured by CMR or echocardiography) and symptoms as per NHYA classification within
      1 year of their CMR scan.

      A diagnosis of arrhythmia was made if the patient had documented ECG evidence within 1 year
      of their CMR scan.

      This information will be gathered retrospectively by access to outpatient clinic letters,
      hospital notes, CMR/ echo reports and clinical details recorded in a proforma at the time of
      the CMR scan. Some of the clinical data would be obtained from other hospitals.

      Patient scans will only be used if between the dates of 1999-2005. As all other data is in
      respect to the year immediately post scan then no further data will be required on any
      patient post 2006.

      Logistic regression will be used to determine whether T2* is predictive of cardiac
      complications in the 12 months after a patient's CMR scan. Since some patients will have more
      than 1 scan, a mixed model logistic regression will be used to take account of any
      within-patient correlation that may occur.

      The data will be analysed by Dr Michael Roughton (Medical Statistician, Royal Brompton
      Hospital)

      The results will be disseminated through peer review journals
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Please note that the age range detailed above refers to the normal group (63 patients): the
        study article provided by the study team to complete this record only provides a mean age
        range for the 39 Left Ventricular Dysfunction Group (50.1 +/- 14.0 years) and 24 Septal
        Infarction Group (58.6 +/- 13.9).