Beta-cryptoxanthin Supplement: Absorption and Function
Condition: Beta-cryptoxanthin Supplementation
Study type: Interventional

Summary: 
      Beta-cryptoxanthin (BCX) is a naturally occurring member of the carotenoid family, found in a
      wide range of fruits and vegetables. The unique biological functions of BCX have not been
      well-established, although BCX, like other members of the carotenoids have antioxidant
      functions. BCX, may also serve as a precursor of Vitamin A. Vitamin A has a wide range of
      functions including maintain immunity, vision, growth and development. Whilst not specific
      for BCX, epidemiological studies indicate that dietary intake of carotenoids may be of
      benefit in maintaining cognitive health and reducing stress via its antioxidant,
      anti-inflammatory and immunomodulatory properties. This pilot study aims to establish the
      relationship between supplemental dose and circulating concentrations of BCX and related
      carotenoids in circulation. Results obtained from this study will provide greater insight of
      bioavailability and carotenoid metabolism, necessary for larger supplementation in selected
      target populations.
    

Detailed description: 
      In previous Singapore maternal and child health cohort study, Growing up towards healthy
      outcomes (GUSTO), it established potentially significant health function to be significantly
      correlated with BCX. At childbirth, mothers' blood concentrations of carotenoids, including
      α-, β-carotene and BCX were simultaneously measured by ultra-performance liquid
      chromatography. Unique to the carotenoids, there was a correlation between higher maternal
      plasma concentrations of BCX with lower rates of depression and reduced anxiety scores during
      pregnancy for the mother. Furthermore, the concentrations of BCX were uniquely correlated
      with child neurocognitive function by age 2 years.

      Current studies have only been food-based efficacy trials with an increase of dietary BCX
      intake through BCX-rich foods in humans. There have been no direct assessments of risk
      associated with BCX exposure, and current evidence in the literature does not identify any
      consistent, substantial risks for any level of BCX supplementation. Overall, the utility of
      BCX as a pro-vitamin A is clear, but evidence towards benefits beyond this role is
      inconsistent.

      Hence, this is a pilot study that will aim to examine bioavailability of a novel BCX
      preparation supplemented at 2 doses (3mg and 6mg daily) versus placebo, consumed once daily
      in a randomised, doubled-blinded parallel trial, in healthy female subjects of reproductive
      age.
    

Intervention name(s): Beta-cryptoxanthin (BCX)
Intervention type(s): Dietary Supplement
Intervention description(s): Subjects will be randomised into one of the three study treatment arms.
Intervention MeSH terms: Beta-Cryptoxanthin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Basic Science
Keywords: Beta-cryptoxanthin; Supplementation; Carotenoids; Bioavailability