bioihbjkbjnl/mcl2 huggingface dataset:
Effect of Two Pilates-based Mat Exercise Programs on the Isometric Strength of Core Muscles in Healthy Men
Condition: Healthy Volunteers
Study type: Interventional

Summary: 
      Based on the current evidence, it is known that Pilates is an exercise technique that has
      been used mainly by women in sport, fitness and rehabilitation. Most research has been
      developed with women. The participation of men in the research studies is reduced and
      methodology rigor is low, therefore, there is insufficient evidence on the effects of this
      type of training in men, in addition, there are no studies that have proven the effects of a
      Pilates-based mat exercise with resistance band on strength of core muscles.

      The main objective of this research is to identify the effects of a Pilates-based mat
      exercise program versus a Pilates-based exercise mat program with resistance band on the
      isometric strength of the core muscles in men 18 to 25 years.
    

Detailed description: 
      Fifty-eight men will be randomly assigned to one of two Pilates exercise programs.
      Pilates-based mat exercise and Pilates-based mat exercise with Theraband® (blue color).
      Interventions will be performed three times a week for eight-weeks on alternate days. Half
      will perform Pilates-based mat exercise and the remaining 29 will perform Pilates-based mat
      exercise with Theraband®. Both groups complete eleven exercises from week one to four and
      twelve exercises from week five to eight.
    

Intervention name(s): Pilates exercise with Theraband; Pilates exercise
Intervention type(s): Behavioral; Behavioral
Intervention description(s): The experimental group will perform all the exercises with Theraband® in the same manner than active comparator group.; The active comparator group will perform all the exercises without Theraband®
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effects of Cash Transfer for the Prevention of HIV in Young South African Women
Condition: HIV
Study type: Interventional
Phase: Phase 3

Summary: 
      Cash transfers to young women for staying in school and its effect on acquiring HIV
    

Detailed description: 
      The overall purpose of this study is to determine whether providing cash transfers to young
      women and their household, conditional on school attendance, reduces young women's risk of
      acquiring Human Immunodeficiency Virus (HIV). The overall goal of the Conditional Cash
      Transfer (CCT) intervention is to reduce structural barriers to education with the goal of
      increasing school attendance of young women, thereby decreasing their HIV risk.
    

Intervention name(s): monthly cash transfer payments for attending school; B--No cash transfers
Intervention type(s): Behavioral; Behavioral
Intervention description(s): In the intervention, young women and their households will be randomized in 1:1 ratio to receive monthly cash transfer payments, conditional on the young woman attending school, or to the control arm. Young women will be recruited at the beginning of grades 8 through 11 in the first year of the study.; No monthly cash transfers
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
A Device Study in Healthy Participants
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The main purpose of this study is to evaluate the safety and tolerability of two different
      devices that may be used to inject medication just under the skin. Participants will receive
      placebo; no active drug will be given. The study will last up to five weeks for each
      participant, including a one-week overnight stay in the study center.
    


Intervention name(s): On-Body Delivery System (OBDS)/Multiple Bolus Injector; Single Auto Injector; Placebo
Intervention type(s): Device; Device; Drug
Intervention description(s): Used to administer placebo SC.; Used to administer placebo SC.; Administered SC.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Dose-finding Study to Evaluate the Safety, Tolerability, PK, and PD of CK-3773274 in Adults With HCM
Condition: Hypertrophic Cardiomyopathy (HCM)
MeSH terms: Cardiomyopathies; Cardiomyopathy, Hypertrophic; Hypertrophy
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is being performed to understand the effect of different doses of CK-3773274 on
      patients with hypertrophic cardiomyopathy (HCM).
    


Intervention name(s): CK-3773274 (5 - 15 mg); CK-3773274 (10 - 30 mg); Placebo for CK-3773274
Intervention type(s): Drug; Drug; Drug
Intervention description(s): CK-3773274 tablets administered orally; CK-3773274 tablets administered orally; Placebo administered orally
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: CK-3773274; CK-274; obstructive hypertrophic cardiomyopathy; oHCM; REDWOOD-HCM; non-obstructive hypertrophic cardiomyopathy; nHCM; hypertrophic cardiomyopathy; HCM
Assessment of Lumbar Spine Active Range of Motion in Women Who Were Experienced Cesarean or Vaginal Birth
Condition: Cesarean and Vaginal Birth Complications
Study type: Observational

Summary: 
      Pregnancy may impact the musculoskeletal apparatus of females through pregnancy-associated
      biomechanical, vascular, and hormonal changes. Pregnant females may complain of lumbopelvic
      pain, especially during their last trimester. This lumbopelvic pain can be the result of an
      enlarged uterus and unstable lumbopelvic joints.
    

Detailed description: 
      Cesarean birth can affect the lumbopelvic biomechanics through its impact on the sacroiliac
      joints and the abdominal muscles. while vaginal birth can trigger lumbopelvic pain through
      its impact on the pelvic joints like the symphysis pubis and sacroiliacs.

      When puerperium is finished, most of these pregnancy-related changes assume its prepregnant
      conditions.

      Physiotherapists are responsible for providing PT care for women to improve their quality of
      life during the puerperium and even during the delayed postpartum interval.
    

Intervention name(s): Bubble Inclinometer and Digital Pelvic Inclinometer
Intervention type(s): Device
Intervention description(s): They are valid and reliable devices to measure the range of motion of the lumbar spine
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        95 women participated in this study. They were recruited from the Woman and Child Hospital
        of South Valley University, located in Qena governorate, Egypt.
Peds Metabolic Syndrome in Psoriasis
Condition: Psoriasis; Metabolic Syndrome
MeSH terms: Psoriasis; Metabolic Syndrome; Syndrome
Study type: Observational

Summary: 
      The objective of this study is to assess whether there is an increased risk of the metabolic
      syndrome in children with psoriasis compared to children without psoriasis.
    

Detailed description: 
      Adult patients with psoriasis, especially those who are young and with severe disease, have
      an increased prevalence of myocardial infarction and metabolic syndrome, and increased
      mortality. Tumor Necrosis Factor (TNF) and other inflammatory cytokines are felt to play an
      important role not only in the pathogenesis of psoriasis and psoriatic arthritis, but in the
      pathogenesis of the metabolic syndrome and increased cardiovascular mortality and morbidity.

      However, the prevalence of metabolic syndrome and surrogate markers of increased
      cardiovascular risk, such as lower flow-mediated dilation (FMD) during reactive hyperemia,
      measured by high-resolution brachial artery ultrasound, lower hyperemia-induced, pulse wave
      amplitudes as measured by finger plethysmograph peripheral artery tonometry, and elevated
      blood CRP levels, in children with psoriasis, are unknown.

      We will use the definition of metabolic syndrome described by de Ferranti: Participants are
      defined as having metabolic syndrome if they meet or exceed the criteria for 3 or more of the
      following 5 variables: 1) triglycerides ≥1.1 mmol/L; 2) HDL cholesterol <1.3 mmol/L; 3)
      fasting blood glucose ≥6.1 mmol/L; 4) waist circumference (cm) >75th percentile for age and
      sex; and 5) systolic or diastolic blood pressure (mm Hg) >90th percentile for age, sex, and
      height.

      The following two noninvasive procedures will be used to assess additional cardiovascular
      risk: flow mediated dilation (FMD) and finger plethysmography peripheral artery tonometry
      (PAT). These procedures have been used extensively to measure adults for clinical study
      purposes for many years.

      As a control group, we will compare children with psoriasis to age-, race-,and gender-matched
      children with warts.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        These subjects will be recruited from the pediatric Dermatology Clinic at Tufts Medical
        Center, community physician referral, and advertisements.
      
Biospecimen description: 
      Whole blood and serum
    
Keywords: Psoriasis; Metabolic Syndrome; Cardiovascular Risk
Effect Of Non-Surgical Periodontal Treatment On Lipoxin a4 Levels
Condition: Periodontitis
MeSH terms: Periodontitis
Study type: Interventional

Summary: 
      The aim of this study was to evaluate the levels of lipoxin A4 (LXA4), prostaglandin E2
      (PGE2) and leukotriene B4 (LTB4) in gingival crevicular fluid (GCF) and saliva in individuals
      with periodontal healthy and chronic periodontitis. In addition, the investigators evaluated
      the levels of these mediators after non-surgical periodontal treatment in patients with
      chronic periodontitis. A total of 20 subjects, 10 patients with chronic periodontitis (CP)
      and 10 periodontally healthy individuals were included in the study. Clinical parameters
      including plaque index (PI), gingival index (GI), probing depth (PD) and clinical attachment
      levels (CAL) were recorded. GCF and saliva samples were obtained at the beginning of the
      study from all individuals. GCF and saliva samples were re-collected from patients with CP at
      1 month after non surgical periodontal therapy.
    


Intervention name(s): Non-surgical periodontal treatment
Intervention type(s): Procedure
Intervention description(s): Mechanical non-surgical treatment were performed
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Gingival Crevicular Fluid; Lipid Mediator; Periodontal Treatment
Evaluation of Efficacity and Safety of Deep Brain Stimulation (DBS) in Chronic and Treatment-Resistant Cluster Headache(CH)
Condition: Cluster Headache
MeSH terms: Cluster Headache; Headache
Study type: Interventional

Summary: 
      The aim of this study is to evaluate the efficacy and safety of deep brain stimulation (DBS)
      in chronic and treatment-resistant CH. Inclusion criteria are: patients with chronic CH
      (>3years), with daily attack and non response to adequate treatment. Electrodes are implanted
      stereotactically in the postero-inferior hypothalamus. In this crossover, randomized,
      placebo-controlled double-blinded study, the efficacy of DBS is evaluated using comparison of
      two one-month sequences: one with stimulation "on" and the other with stimulation "off"
      (placebo sequence). Efficacy is defined as ≥50% decrease of weekly frequency of CH attacks.
      After the randomized period, long-term efficacy and safety are evaluated after one year of
      stimulation in open conditions.
    

Detailed description: 
      Over the past 7 years, deep brain stimulation (DBS) has been used in various centres to treat
      patients with intractable chronic cluster headache (CH). Results in these non-controlled
      studies were encouraging but need to be confirmed in controlled conditions. The aim of this
      study is to evaluate the efficacy and safety of DBS in chronic and treatment-resistant CH, in
      randomized placebo-controlled conditions.

      Inclusion criteria are: patients with chronic CH (>3years), with daily attack and non
      response to adequate treatment (verapamil up 960 mg/d, lithium with plasmatic level 0.6-1
      mEq/ ml, and association of both drugs). After induction of local anaesthesia, electrodes are
      implanted stereotactically in the postero-inferior hypothalamus according to the previously
      described coordinates, and connected to a sub-cutaneous generator. In this crossover,
      randomized, placebo-controlled double-blinded study, the efficacy of DBS is evaluated using
      comparison of two one-month sequences: one with stimulation "on" and the other with
      stimulation "off" (considered as the placebo sequence). Primary efficacy is defined as ≥50%
      decrease of weekly frequency of CH attacks, compared to a prospective run-in pre-implantation
      period. Safety and tolerability are clinically and biologically assessed. After the
      randomized period, long-term efficacy and safety are evaluated after one year of stimulation
      in open conditions.
    

Intervention name(s): setting-up of an electrode in deep brain
Intervention type(s): Procedure
Intervention description(s): deep brain stimulation of the postero-inferoir hypothalamus
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double
Primary purpose: Treatment
Keywords: deep brain stimulation; cluster headache; hypothalamus
Visualization in Shoulder Arthroscopy With and Without Epinephrine
Condition: Visualization in Shoulder Arthroscopy
Study type: Interventional

Summary: 
      Adequate visualization during shoulder arthroscopy is of great importance for the procedure
      to be efficiently and effectively performed. The use of dilute epinephrine in irrigation
      fluid has been historically utilized to help with visualization. Given the potential safety
      issues documented in the literature related to epinephrine use, as well as the significant
      improvements in technique and instrumentation over the last decade, the need for this
      additive should be reexamined. The objective of the current study was to compare surgeon
      determined visualization in shoulder arthroscopy using irrigation fluid with and without
      epinephrine.
    


Intervention name(s): visualization in shoulder arthroscopy
Intervention type(s): Other
Intervention description(s): Evaluating the effect of performing shoulder arthroscopy with and without epinephrine on visualization
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: shoulder arthroscopy, epinephrine, visualization
Ultrasound-guided Bilateral Rectus Sheath Block for Robotic Single-port Gynecologic Surgery
Condition: Gynecologic Disease
MeSH terms: Genital Diseases, Female
Study type: Interventional

Summary: 
      Rectus sheath block (RSB) is a kind of anterior abdominal wall block. It has postoperative
      analgesic effect for abdominal surgery with midline incision. Robotic gynecologic surgery is
      accompanied by significant postoperative pain and usually IV-PCA is used to manage the
      pain.The purpose of this study is to investigate the analgesic effect of ultrasound-guided
      RSB to single-port robotic gynecologic surgery which has incision site at umbilical area.
      Patients will randomly assigned to two groups, RSB group and Control group. Each patients
      will assessed for time to first rescue analgesia, verbal numerical rating pain scores, number
      of rescue analgesic demands, and postoperatively opioids use by IV-PCA by a blinded
      investigator at 0, 1, 6, 12, 24 and 48 hours postoperatively.
    

Detailed description: 
      Patients of RSB group will be performed ultrasound-guided bilateral RSB after induction of
      general anesthesia. The procedure will be performed bilaterally and 15 ml on each side, total
      30 ml of 0.25% ropivacaine will be injected. After the procedure, a surgery scheduled will be
      proceeded. Patient of Control group will be proceeded the surgery after induction of
      anesthesia. All patients will use total 100 ml of IV-PCA containing 800 µg of fentanyl for 48
      hours postoperatively. If a patient complains pain more intense than VNRS 4 or demands an
      analgesic drug, a rescue analgesic would be allowed.
    

Intervention name(s): Rectus sheath block; Ropivacaine; Bandage; IV-PCA containing Fentanyl
Intervention type(s): Procedure; Drug; Other; Drug
Intervention description(s): Ultrasound-guided bilateral rectus sheath block of RSB group using 0.25% Ropivacaine; Ultrasound-guided bilateral rectus sheath block of RSB group using 0.25% Ropivacaine; After the surgery, a bandage will be attached on injection site where is same as the incision site of surgery.; All patients will use total 100 ml of IV-PCA containing 800 µg of fentanyl for 48 hours postoperatively.
Other intervention name(s): RSB; Naropin; Intravenous patient controlled analgesia using fentanyl
Intervention MeSH terms: Fentanyl; Ropivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Evaluating the Safety and Immune Response to a Respiratory Syncytial Virus (RSV) Vaccine in Adults, RSV-Seropositive Children, and RSV-Seronegative Infants and Children
Condition: Respiratory Syncytial Virus Infections
MeSH terms: Respiratory Syncytial Virus Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      Human respiratory syncytial virus (RSV) is a common cause of upper respiratory tract
      illnesses as well as more severe lower respiratory illnesses, including bronchiolitis and
      pneumonia. RSV affects almost all children within the first 2 years of life. This study will
      evaluate the safety and immune response to the RSV MEDI ΔM2-2 vaccine among adults,
      RSV-seropositive children, and RSV-seronegative infants and children.
    

Detailed description: 
      The purpose of this study is to evaluate the safety and immune response of the RSV MEDI ΔM2-2
      vaccine in the four groups of participants. The study vaccine will be evaluated in adults, in
      RSV-seropositive children, and in a dose-ranging study in two groups of RSV-seronegative
      infants and children.
    

Intervention name(s): RSV MEDI ΔM2-2 vaccine; Placebo vaccine
Intervention type(s): Biological; Biological
Intervention description(s): Given intranasally once at a baseline study visit, at a dose of 10^5 or 10^6 plaque-forming units (PFU), depending on study arm.; Given intranasally once at a baseline study visit
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Prevention
Does Chewing Gum Hasten Return of Bowel Function Post-Operatively in Patients Undergoing Spinal Surgery
Condition: Return of Bowel Function Following Spinal Surgery
Study type: Interventional

Summary: 
      The specific aim of this prospective, randomized controlled trial is to compare the effect of
      chewing gum on the return of bowel function in a group of patients undergoing spinal surgery
      with a group of matched controls that do not receive any chewing gum. A 24-hour reduction in
      time to passage of first flatus will be considered an important clinical difference.

      The research questions are:

        1. Does providing chewing gum post-operatively hasten the return of bowel function?

        2. Does providing chewing gum post-operatively reduced overall length of stay?

        3. Does providing chewing gum post-operatively have any associated complications?

        4. Does providing chewing gum post-operatively result in higher objective outcomes scores?

      The secondary aims are:

        1. To compare hospital length of stay between the groups with a mean of ½ day considered
           clinically important.

        2. To compare time until tolerating regular diet as defined as two consecutive meals with
           no complications with 24 hours considered statistically significant.

        3. To compare incidence and nature of complications between the two groups.

        4. To compare the time until completion of rehab milestones with 1 day being considered
           clinically important.

        5. To compare the requirement for nutrition evaluations

        6. To compare SF-12 scores as a marker of patient satisfaction with a difference of 10
           points or more measured between the two groups upon discharge from hospital and at
           six-weeks after surgery.
    


Intervention name(s): Chewing gum
Intervention type(s): Dietary Supplement
Intervention description(s): Patients will be asked to chew gum three times a day for 30 minutes each time
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Network & Dyad HIV Prevention Intervention for IDU's - 1
Condition: HIV; Hepatitis
MeSH terms: Hepatitis
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate a peer-based HIV prevention intervention that
      targets active injection drug users and their drug and sex partners.
    

Detailed description: 
      HIV seroincidence among injection drug users remains high, with unprotected sexual contact
      substantially contributing to new HIV infections among injection drug users (IDUs).
      Interventions that are culturally competent and target drug users' main sex and drug partners
      may be especially effective for HIV/STI and HCV control and prevention.

      The intervention to be tested in this study draws upon theoretical and empirical evidence
      suggesting that peer educator programs can have significant effects on the risk-related
      behaviors of both the educators and the peers whom they educate. Specifically, through group
      and individual focused sessions, participants learn and practice skills designed to reduce
      drug and sex related risk behaviors. Furthermore, individuals and their main risk partners
      attend a training session that focuses on risk reduction within their relationship.
    

Intervention name(s): Intervention Condition; Control Condition
Intervention type(s): Behavioral; Behavioral
Intervention description(s): In the intervention Condition participants were trained to be Health Educators. The intervention focused on HIV risk reduction by teaching knowledge and skills to reduce injection, drug splitting, and sex risk, and by teaching communication skills to conduct outreach to personal risk network members. The intervention consisted of five group-based sessions, one individual session, and one dyad session with a risk network member.; The control condition focused on injection drug-use related topics (e.g. HIV testing, Hepatitis C and drug overdose). The sessions were educational and did not include skills training. The control condition consisted of five group-based sessions.
Other intervention name(s): STEP into action
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: HIV prevention Intervention, injection drug user,peer-oriented, randomized controlled trial, social network