bioihbjkbjnl/mcl2 huggingface dataset:
Optimizing the Temperature for Embryo Culture in In Vitro Fertilization
Condition: Infertility
MeSH terms: Infertility
Study type: Interventional

Summary: 
      Many human and animal studies over the past 40 years have revealed that ovaries and Fallopian
      tubes have a lower temperature than core body temperature, especially around the time of
      ovulation and early embryo development. Whether average core body temperature, 37 degrees
      Celsius, is ideal temperature for culture has not been prospectively evaluated. The purpose
      of this study is to determine whether lowering the incubator temperature by 1 degree Celsius
      will result in meaningful improvements in embryo development and pregnancy rates.

      Patients participating in this study will undergo routine in vitro fertilization (IVF)
      stimulation. Following egg retrieval, patients with at least 8 mature eggs will have those
      eggs divided randomly into two groups. Both groups will then under ICSI (intra-cytoplasmic
      sperm injection) to fertilize the eggs. The groups will randomly be assigned to control or
      study condition. The control condition group will be cultured at 37 degrees Celsius, the
      current standard of care. The study group will be cultured at 36 degrees Celsius. All other
      culture conditions will be kept identical and embryos will be assessed on day 3 and day 5 of
      development.

      On day 5, all well-developed blastocysts will undergo biopsy for Comprehensive Chromosomal
      Screening (CCS), which will evaluate the chromosomal normalcy of the embryo . Patients will
      undergo transfer on the morning of day 6 and the highest quality, chromosomally normal embryo
      from each group (the 36 degree cultured embryos and the 37 degree cultured embryos) will be
      transferred. If only 1 embryo is available for transfer, the patient will have a single
      embryo transfer.

      All embryos available for cryopreservation will undergo biopsy for CCS before being frozen.
      Some arrested embryos from each temperature group will also undergo genetic analysis to
      evaluate chromosomal normalcy or mosaicism.

      The female patient will undergo a blood draw at 9 weeks gestation and buccal swabs will be
      obtained from the infant(s) after birth.
    


Intervention name(s): 36 degrees Celsius
Intervention type(s): Other
Intervention description(s): Embryos in this group will be cultured in incubators set to 36 degrees Celsius.
Other intervention name(s): IVF, PGD, embryos, culture, CCS, infertility
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Keywords: IVF; infertility; PGD; embryo; temperature; incubator; CCS; culture; incubator-36 degrees Celsius; incubator-37 degrees Celsius
Efficacy and Safety of Novel Formulations of Topical Calcipotriol in Patients With Mild to Moderate Plaque Psoriasis
Condition: Psoriasis Vulgaris
MeSH terms: Psoriasis
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This was a Phase I, single-center, randomized, controlled trial to evaluate the antipsoriatic
      efficacy of calcipotriol in novel formulations based on AKVANO technology as compared to
      marketed calcipotriol products (Daivonex® solution and cream) and to evaluate their cutaneous
      safety in a psoriasis plaque test
    

Detailed description: 
      This study was conducted to evaluate the efficacy and cutaneous safety of calcipotriol (50
      μg/g) in novel formulations (AKVANO®) as compared to their corresponding vehicle formulations
      and marketed calcipotriol formulations (Daivonex®) in a psoriasis plaque test. In total, 24
      subjects with chronic psoriasis vulgaris were enrolled in this single-centre, randomized,
      vehicle and comparator-controlled clinical trial and were treated under occlusion over a
      12-day treatment period (10 applications). The anti-psoriatic effect was evaluated by
      sonographic measurement of the psoriatic infiltrate and investigators' clinical efficacy
      assessments.
    

Intervention name(s): AKVANO-Calcipotriol formulation 1; AKVANO-Calcipotriol formulation 2; AKVANO vehicle formulation 1; AKVANO vehicle formulation 2; Daivonex solution; Daivonex cream
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Novel lipid based formulation (AKVANO) type 1 containing Calcipotriol (50 μg/g); Novel lipid based formulation (AKVANO) type 2 containing Calcipotriol (50 μg/g); Novel lipid based formulation (AKVANO) vehicle 1; Novel lipid based formulation (AKVANO) vehicle 2; Daivonex solution containing Calcipotriol (50 μg/g); Daivonex cream containing Calcipotriol (50 μg/g)
Other intervention name(s): AKVC01; AKVC02; AKVC01 vehicle; AKVC02 vehicle
Intervention MeSH terms: Calcitriol; Calcipotriene
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: psoriasis plaque test; sonographic measurement; psoriatic infiltrate; clinical efficacy assessments; cutaneous safety; calcipotriene; calcipotriol
A Pilot Study of Personalized Medicine for Pediatric Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional

Summary: 
      A pilot study to test the feasibility of a personalized asthma care intervention.
    

Detailed description: 
      There are two arms in this study. The control arm of the trial will involve the current
      standard primary care asthma management, and the intervention arm will involve personalized
      asthma management.

      Inclusion criteria include: 1) child age 6-17 years, 2) doctor diagnosed asthma, 3) at least
      one asthma exacerbation in the previous year. Children with other coexistent pulmonary
      diseases such as chronic lung disease and cystic fibrosis will be excluded.

      The period of participation will be three months for each participant. After screening, each
      participant will have an initial clinic visit. During this baseline visit, the investigators
      will collect DNA by taking a saliva sample, the investigators will conduct spirometry, and
      the investigators will survey the families regarding household level environmental exposures,
      demographics, and other key variables. The participant will be randomly assigned to a study
      arm at the end of the baseline visit. The data gathered at the baseline visit will be used to
      develop a management plan. The investigators will mail a plan to the participant and the
      primary care provider within a couple weeks of the baseline visit. The investigators will
      then discuss the plan with the participant via phone. Both groups will receive a plan which
      MAY be used to guide asthma care. Sample letters follow the protocol. The intervention group
      will receive basic information on the skin testing, genetic testing, and spirometry. The
      control group will not receive the genetic information. The control arm will receive the
      genetic information at the end of the study follow up.

      After the baseline visit, the participants will receive a monthly phone call for two months
      to conduct a survey to assess our study outcomes and covariates. At the 3rd month
      participants will return to the GCRC for a final clinic visit. During the final visit the
      investigators will conduct our survey and spirometry and request permission for medical
      record release.
    

Intervention name(s): Personalized Care Plan; Control Standard Care
Intervention type(s): Other; Other
Intervention description(s): We will develop a personalized plan based on info collected in the primary visit; This is the standard care arm
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Asthma; child; pediatric
Abdominal Drainage During Appendicectomy - Resources Down the Drain: A Retrospective Cohort Study
Condition: Appendicitis
MeSH terms: Appendicitis
Study type: Observational

Summary: 
      The investigators performed a retrospective review of all patients undergoing appendicectomy
      from March-November 2018 using the online theatre database and discharge letters. CA was
      defined as patients with perforated or gangrenous appendicitis on histology. Patients were
      divided into 2 groups; Group 1 (G1) included patients with CA who had a drain inserted; Group
      2 (G2) included patients with CA and no drain.
    


Intervention name(s): Abdominal drain
Intervention type(s): Procedure
Intervention description(s): A latex-free drain (size 20F)
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        All patients over the age of 16 with complicated appendicitis (CA) were included. CA was
        defined as histologically proven gangrenous or perforated appendicitis.
Safety and Efficacy of Basiliximab in Calcineurin Inhibitor Intolerant Long-term Kidney Transplant Recipients Treated With Mycophenolic Acid and Steroids
Condition: Kidney Transplantation; Adverse Effects
Study type: Interventional
Phase: Phase 4

Summary: 
      The long-term use of calcineurin inhibitors (CNI) in patients who have received a kidney
      transplantation is associated with renal dysfunction and hypertension. The study will
      evaluate the safety and efficacy of replacing the calcineurin inhibitors by using basiliximab
      at monthly doses.
    


Intervention name(s): basiliximab; MMF/EC-MPS; Corticosteroids
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 40 mg once every 28 days intravenously for 24 weeks; 1g MMF or 720mg EC-MPS p.o twice daily; Oral corticosteroids, equivalent to prednisone p.o, ≥ 5mg daily or ≥ 10mg on alternate days
Other intervention name(s): Simulect; MPA; Myfortic; Cellcept; Prednisone; Methyl-prednisolone
Intervention MeSH terms: Prednisone; Prednisolone; Methylprednisolone; Basiliximab
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Side effects; calcineurin inhibitors; maintenance; basiliximab; Kidney maintenance transplant
Effect of Chronic Consumption of a Cranberry Beverage on Inflammation and Oxidative Stress
Condition: Inflammation
MeSH terms: Inflammation
Study type: Interventional

Summary: 
      The objective of this randomized, double-blind, placebo-controlled, parallel-design clinical
      trial is to investigate the potential antioxidant benefits of a cranberry beverage. The
      investigators hypothesize the chronic consumption of this beverage will improve indices of
      oxidative stress, inflammation, endothelial function, and glucoregulation. The investigators
      also hypothesize that these benefits will be particularly evident following an oral glucose
      tolerance test.
    


Intervention name(s): Cranberry; Non-Cranberry beverage
Intervention type(s): Other; Other
Intervention description(s): beverage containing cranberry at a dose of 15.2 ounces per day for 56 days.; Placebo Comparator - beverage absent cranberry at a dose of 15.2 ounces per day for 56 days.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Effects of Additional Functional Strength Training on Mobility in Children With Hemiplegic Cerebral Palsy
Condition: Hemiplegic Cerebral Palsy; Mobility
MeSH terms: Paralysis; Cerebral Palsy
Study type: Interventional

Summary: 
      The randomized control trail was to determine the effects of additional functional Strength
      Training on mobility in Children with Hemiplegic Cerebral Palsy.
    

Detailed description: 
      The aim of functional physiotherapy is to train the child by emphasizing him to learn motor
      abilities. These motor abilities are those that are thought to be though either by children
      with cerebral palsy or their parents. Functional activities are learned by the repetitive
      practice of goal-oriented tasks in a given functional situation. This approach instead of
      focusing on normality, it focuses on functionality. In this way, it is very necessary for the
      child to practice a given task functionally rather than normally.No studies have been done to
      improve mobility and strength in lower limb in children with hemiplegia cerebral palsy. So
      for this reason, this study is conducted to investigate the effects of additional functional
      Strength Training on mobility in Children with Hemiplegic Cerebral Palsy.In this way we can
      make these children an active participant of the society.
    

Intervention name(s): Functional Strength Training
Intervention type(s): Other
Intervention description(s): In addition to conventional therapy, experimental group was also given functional strength training program. Functional strength training was given as home program consisting of ten tasks.The ten tasks were STS, one leg standing, weight shifting(from one side of body to other), step-ups, lateral step-ups, squatting against wall, picking an object from standing position, walking forward, walking backward and kicking the ball.
Other intervention name(s): conventional therapy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Cerebral palsy; Functional strength training; Mobility; GMFC; GMFM
Postoperative Noninvasive Ventilation After Upper Abdominal Surgery in Chronic Obstructive Lung Disease
Condition: Acute Respiratory Failure Post Surgical (Diagnosis)
MeSH terms: Lung Diseases; Respiratory Insufficiency; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Study type: Interventional

Summary: 
      In Qena university hospital a prospective, randomized study was carried out on 100 COPD
      patients, all were divided into; conventional therapy without NIV (C group) 50 patients or
      with prophylactic NIV(N group) 50 patients.NIV applied for approximately 30 to 45 min at 2-
      to 4-h intervals for 48 h following surgery . Primary endpoint was the acute respiratory
      events (ARE) .Secondary endpoints were acute respiratory failure (ARF), intubation rate,
      mortality rate, infectious and non-infectious complications, and ICU stay.
    


Intervention name(s): NIV
Intervention type(s): Device
Intervention description(s): NIV applied for approximately 30 to 45 min at 2- to 4-h intervals for 48 h following surgery
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Postoperative NIV
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: noninvasive ventilation; COPD; acute respiratory failure
Fascia Iliaca Compartment Block Versus Anterior Quadratus Lumborum Block
Condition: Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      Fractures of the femur are common orthopaedic emergency especially in the geriatric
      population and central neuraxial blocks are the preferred technique for providing
      anaesthesia. However, limb immobility and extreme pain are the deterrents for ideal
      positioning for these procedures. postoperative pain is a nightmare so adequate analgesia has
      been advocated to reduce the pain. in this study, Facia Iliaca compartment block will be
      compared to anterior Quadratus lumborum block, both will be done Ultrasound-guided using
      Bupivacain0.25% for postoperative analgesia at the end of the surgery.
    

Detailed description: 
      In this prospective, randomized, comparative study patients will be equally divided into two
      equal groups; GroupI: patients will receive Ultrasound-guided Facia Iliaca compartment block
      with 50 ml 0.25%bupivacaine at the end of surgery Group Q: patients will receive
      Ultrasound-guided anterior Quadratus lumborum block with 50 ml 0.25%bupivacaine at the end of
      surgery
    

Intervention name(s): Facia Iliaca block; Anterior Quadratus Lumbroum block; bupivacaine
Intervention type(s): Procedure; Procedure; Drug
Intervention description(s): patients will receive Ultrasound-guided Facia Iliaca block using 50 ml 0f Bupivacaine 0.25%; patients will receive Ultrasound-guided Anterior Quadratus Lumbroum block using 50 ml 0f Bupivacaine 0.25%; bupivacaine
Intervention MeSH terms: Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Fibrates in Pediatric Cholestasis
Condition: Chronic Cholestasis
MeSH terms: Cholestasis
Study type: Interventional
Phase: Phase 2

Summary: 
      A study conducted to assess the effect of fibrates on pruritus and biochemical picture in
      pediatric patients with cholestatic liver diseases.
    

Detailed description: 
      Cholestatic liver disorders include a spectrum of hepatobiliary diseases of diverse
      etiologies that are characterized by impaired hepatocellular secretion of bile, resulting in
      accumulation of bile acids, bilirubin and cholesterol.This could result in different clinical
      features including pruritus, malabsorption and vitamin deficiencies with subsequent
      coagulation disorders and bone disease. Persistence of cholestasis leads to biliary fibrosis
      which can progress to liver cirrhosis and end-stage liver disease.

      Nuclear receptors (NRs) regulate ligand-activated transcription factor networks of genes for
      the elimination and detoxification of potentially toxic biliary constituents accumulating in
      cholestasis. Activation of several NRs also modulates fibrogenesis, inflammation, and
      carcinogenesis as sequelae of cholestasis. Hence, It represent attractive targets for
      pharmacotherapy of cholestatic disorders.

      Several already available drugs may exert their beneficial effects in cholestasis via NR
      activation eg, ursodeoxycholic acid via glucocorticoid receptor and pregnane X receptor, and
      rifampicin via pregnane X receptor. Unfortunately, Some patients may not respond to these
      medications.

      Fibrates, serum Lipid lowering medication, has a stimulation action on proliferator activated
      receptor alpha. It is a nuclear receptor with an integral role in bile homeostasis. Several
      case reports and pilot studies have demonstrated the efficacy of fibrates in reducing serum
      biomarkers of cholestasis and liver function abnormalities in patients with incomplete
      response to ursodeoxycholic acid monotherapy. These results are of interest, because fibrates
      are attracting increased attention as adjunct therapy for chronic cholestatic liver diseases.
    

Intervention name(s): Lipanthyl; Ursogal
Intervention type(s): Drug; Drug
Intervention description(s): Tablet; suspension
Other intervention name(s): ursogal; non
Intervention MeSH terms: Ursodeoxycholic Acid; Fenofibrate
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: pediatric cholestasis, Fibrate
Creating a Comfortable Cafeteria: Staff and Student Feedback - Outcome Study (Cafeteria Prog)
Condition: School Health Services
Study type: Observational

Summary: 
      A mixed methods design was used to explore the outcomes of a 6-week, occupational therapy-led
      Comfortable Cafeteria program designed to build capacity of cafeteria supervisors to create a
      positive mealtime environment so that all students can successfully participate in and enjoy
      their meal and socialization with peers.
    

Detailed description: 
      A mixed methods design was used to explore the outcomes of a 6-week, occupational therapy-led
      Comfortable Cafeteria program designed to build capacity of cafeteria supervisors to create a
      positive mealtime environment so that all students can successfully participate in and enjoy
      their meal and socialization with peers. Statistically significant improvements in pretest
      posttest visual analogue scale ratings of participation in and enjoyment for students with
      low and mid-range scores at the outset was found. Cafeteria supervisors demonstrated
      statistically significant improvements in perceptions of having the knowledge and skills to
      supervise and to encourage healthy eating based on pretest posttest ratings. Qualitative
      findings add further insight about the program suggesting that students learned prosocial
      values (e.g. being kind, helping others), supervisors actively encouraged positive social
      interaction, and occupational therapy practitioners enjoyed implementing the Comfortable
      Cafeteria program and recognized positive supervisor and student changes as a result of
      integrating services in the cafeteria.
    

Intervention name(s): Comfortable Cafeteria Program
Intervention type(s): Behavioral
Intervention description(s): 6-week program integrated into the cafeteria lunchtime to build capacity of supervisors and students to create a positive social and emotional atmosphere so that students can enjoy eating their lunch and socializing with peers.
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        366 kindergarten through 4th grade students

        18 cafeteria supervisors
      
Keywords: school lunch; occupational therapy