bioihbjkbjnl/mcl2 huggingface dataset:
Displacement Between PVC and Silicon DLT
Condition: Endotracheal Tube Wrongly Placed During Anesthetic Procedure; Surgical Procedure, Unspecified
Study type: Interventional

Summary: 
      The purpose of this study is to compare difference of displacement between Polyvinyl
      Chloride(PVC) and Silicon double-lumen endobronchial tubes(DLTs) during changing position
      from supine to lateral in thoracic surgery.
    

Detailed description: 
      Lung isolation and differential lung ventilation, resulting in collapse of operative lung and
      ventilation of non-operating lung (one lung ventilation; OLV) are essential for thoracic
      surgery in lung, esophagus and thoracic aorta.

      DLT, consisted of tracheal and bronchial lumens, is commonly used to perform differential
      lung ventilation. The correct position of each lumen in trachea and main bronchus is
      essential for successful OLV. However, DLT displacement occurs commonly while patients are
      changed position from the supine to the lateral. The deleterious consequences of a
      malpositioned DLT can be substantial, even life-threatening including severe hypoxemia.

      Considering displacement of DLT during position change and surgical traction, previous
      studies recommended endobronchial cuff of DLT should be positioned at 0.5cm below the
      tracheal carina when using left-sided DLT. However, it is based on the data from several
      research conducted by PVC DLT.

      These days, Silicon DLT, different in material from PVC DLT, is also widely used in clinical
      practice. Silicon DLT is different in not only position of ballon but also distance of each
      lumen. Furthermore,there are no identified studies about the displacement of silicon DLT
      during patient position change in thoracic surgery.

      Therefore, it is necessary to measure the movement of silicon DLT during positional change
      from supine to lateral for finding the proper positioning of DLT.

      The investigators compare the difference of displacement between PVC DLT and silicon DLT
      distance during positional change from supine to lateral by fiberotic bronchoscope. And the
      investigators try to find proper position of PVC and silicon DLT, respectively, to perform
      safe and successful OLV during thoracic surgery.
    

Intervention name(s): PVC DLT; silicon DLT
Intervention type(s): Device; Device
Intervention description(s): PVC DLT is type of double lumen tube that is composed of PVC; silicon DLT is type of double lumen tube that is composed of silicon
Other intervention name(s): PVC double-lumen tube; silicon double-lumen tube
Intervention MeSH terms: Silicon
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: one lung ventilation; double lumen endobronchial tube; displacement; Fiberoptic bronchoscope
A Randomized Trial Comparing Metered Dose Inhalers and Breath Actuated Nebulizers
Condition: Asthma
Study type: Interventional

Summary: 
      This study is determines if metered dose inhalers are as effective as breath actuated
      nebulizers for the treatment of mild to moderate asthma exacerbations in pediatric patients
      presenting to the emergency department. Half of the participating patients received albuterol
      via the metered dose inhaler whereas the other half received albuterol via the breath
      actuated nebulizer.
    

Detailed description: 
      Albuterol administered via metered dose inhalers with spacers are more effective than small
      volume nebulizers in the treatment of acute pediatric asthma exacerbations. There is also
      supporting data that the breath actuated nebulizers are also more effective than small volume
      nebulizers. The effectiveness of breath actuated nebulization compared to MDI for treating
      asthma exacerbations is less well defined.

      Metered dose inhalers with spacers are more readily available to the general population, are
      easily transportable and do not require a power source. Demonstrating equal effectiveness of
      albuterol delivery systems for treatment of acute pediatric asthma exacerbations would enable
      physicians to confidently utilize clinical encounters as opportunities to educate families on
      management of asthma exacerbations using their home appliance.
    

Intervention name(s): Metered Dose Inhaler; Breath Actuated Nebulizer
Intervention type(s): Device; Device
Intervention description(s): A metered dose inhaler (MDI) is a small hand held pressurized canister device that contains both a medication, in this case albuterol, and a propellant. Pressing the device delivers 90mcg of albuterol. The MDI is attached to a spacer device, which is a one way holding chamber which allows the medication to be delivered over a series of breaths.; The breath actuated nebulizer (BAN) device is a device that converts liquid medication, in this case albuterol, into an aerosol. It consists of a mouthpiece, a medication reservoir, and connective tubing that attaches to a compressor. This BAN device delivers medication when the patient takes a breath, but it can be attached to a mask and set to continuous nebulization for patients that are not able to coordinate their breaths.
Other intervention name(s): Aerochamber, AWA852-02; AeroEclipse
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: pediatrics; metered dose inhalers; breath actuated nebulizers
Evaluation of Carbohydrates - Glycemic Index
Condition: Glycemic Index
Study type: Interventional

Summary: 
      This study is an open-label with a randomized, cross-over design using standard GI
      methodology.
    


Intervention name(s): Control Meal 1; Control Meal 2; Experimental Nutritional Product
Intervention type(s): Other; Other; Other
Intervention description(s): carbohydrate test meal; carbohydrate test meal; ready to drink nutritional formulation
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Other
Levels of Circulating T Cells Expressing VLA-1 Collagen Receptors
Condition: Ischemic Heart Disease
MeSH terms: Heart Diseases; Myocardial Ischemia; Coronary Artery Disease
Study type: Observational

Summary: 
      The examination of the percentage of peripheral T cells carrying VLA-1 in ischemic heart
      disease patients. The hypothesis is that the percentage levels of cells carrying this
      integrin rise according to the severity of the ischemic heart disease.
    

Detailed description: 
      Atherosclerosis is considered an inflammatory disease in which lymphocytes have an important
      role. The study was disigned to find out the changes in T cell levels carrying VLA-1
      involvement in this process.
    

Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Biospecimen description: 
      Blood samples isolated from patients included in the study and anallysed by FACS
The Utility of Nexium in Chronic Cough and Reflux Disease
Condition: Cough; GERD
MeSH terms: Cough
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this research study is to investigate different doses of proton pump
      inhibitors in reducing cough symptoms felt to be associated with Gastroesophageal reflux
      disease (GERD). Proton pump inhibitors are medicines used to treat GERD, which work by
      lowering the amount of acid in the stomach.

      The proton pump inhibitor used in this study is called, Esomeprazole (brand name Nexium), and
      is already marketed for treating GERD. Patients with GERD may experience all or some of the
      following symptoms: stomach acid or partially digested food re-entering the esophagus (which
      is sometimes referred to as heartburn or regurgitation), belching and coughing. Even very
      small, unnoticeable amounts of rising stomach acid may cause patients to cough.

      Because there may be a link between chronic cough and GERD, study doctors are interested in
      learning if giving high-dose Nexium (40 milligrams, twice daily) will help in treating
      chronic cough.
    

Detailed description: 
      This study will be a randomized, double-blind, placebo controlled, comparative parallel-group
      trial of subjects with chronic cough of unknown origin presenting to the Otolaryngology/ Head
      and Neck Surgery, Pulmonary Medicine, and Gastroenterology outpatient clinics at the
      University of North Carolina Hospital system.

      Potential subjects with chronic cough of unknown origin will be identified through the above
      outpatient clinics. Those who meet the inclusion and exclusion criteria will be asked to join
      the study testing the efficacy of twice daily esomeprazole 40 mg taken for 3 months in the
      setting of chronic cough. Potential subjects will be consented for the study prior to leaving
      the enrolling clinic. A total of 40 subjects will be recruited into our study.
    

Intervention name(s): Esomeprazole; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 40mg capsule BID for 12 weeks; placebo capsule BID for 12 weeks
Other intervention name(s): Brand name is Nexium
Intervention MeSH terms: Esomeprazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Cough; GERD
Effects of Peanut Consumption on Postprandial Inflammation, Glucose and Triglycerides
Condition: Cardiovascular Disease
MeSH terms: Cardiovascular Diseases
Study type: Interventional
Phase: Phase 1

Summary: 
      This pilot study will investigate the effects of acute peanut consumption on markers of
      inflammation, triglycerides and glucose. The hypothesis is that a high glucose/SFA meal will
      increase postprandial production of the inflammatory marker, C-reactive protein (CRP), and
      that the addition of peanuts to the control meal will reduce the production of CRP, as well
      as triglycerides and glucose.
    

Detailed description: 
      Previous research has demonstrated that a single meal high in saturated fatty acids (SFA) and
      glucose can induce increases in IL-6, TNF-α and CRP in abdominally obese and diabetic
      subjects. As over two-thirds of the U.S. population is overweight or obese, it is important
      to identify foods that can attenuate postprandial increases in lipids, glucose and
      inflammation in this population. Therefore, the purpose of the pilot study is to determine
      whether a high SFA / high glucose control meal will induce an acute inflammatory response in
      overweight individuals, and whether the addition of peanuts to this meal will ameliorate this
      response. To ensure that these effects are due to peanuts, and not to the increase in total
      fat, we will compare this response to another test meal that includes an oil blend with a
      similar fatty acid composition to peanuts.
    

Intervention name(s): Peanuts; Glucose and whipping cream; Oil Blend
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Shake containing 3.0oz of peanuts (including skin) + control (heavy whipping cream, glucose and chocolate syrup); An oral liquid glucose (75g) and fat (high saturated fat from 60g heavy whipping cream) load. Chocolate syrup is added for flavor.; Shake containing an oil blend (sunflower, sesame, olive and palm oils) + control (heavy whipping cream, glucose and chocolate syrup). The amount of oil added to the control will provide an equivalent amount of fat to that provided in 3 oz (85g) of peanuts
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Overweight; Obese
Sulforadex in Healthy Volunteers SAD
Condition: Stage, Prostate Cancer
MeSH terms: Prostatic Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      To determine the safety and tolerability of single escalating doses of Sulforadex® in healthy
      male volunteers.
    

Detailed description: 
      This study will be conducted in a randomised, double-blind, placebo-controlled design with
      single ascending doses of Sulforadex® administered to healthy male subjects between 18 to 45
      years of age. Each healthy subject will receive verbal and written information followed by
      signing of the Informed Consent Form (ICF).

      Subjects will be screened within 21 days prior to admission. At this visit a medical
      examination will be performed to assess eligibility of the healthy subject. Screening will be
      conducted over 1 day or may be divided into more than 1 day. The first cohort of the study
      will commence with one sentinel group. The subsequent groups may be dosed together without
      sentinel dosing. The study is expected to have 5 cohorts with a total of 29 healthy male
      subjects:
    

Intervention name(s): Sulforadex; Alpha cyclodextrin
Intervention type(s): Drug; Drug
Intervention description(s): Active compound; Placebo control
Other intervention name(s): Stabilised sulforaphane
Intervention MeSH terms: Sulforaphane
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Neurostimulation and Electromyographs Assessment of th TetraGraph in Healthy (Volunteers
Condition: Electromyography; Neuromuscular Monitoring
Study type: Interventional

Summary: 
      TetraGraph is a newly developed EMG-based (electromyograph), quantitative, battery-powered
      neuromuscular monitoring system intended for daily clinical use. The primary aim of this
      clinical investigation is to examine the applicability (ease of use, equipment need, etc.),
      repeatability (precision or internal consistency) and performance (signal quality, accuracy
      of outcome, voltage of stimulation output before and during a stimulus) and tolerability of
      the Tetragraph device in healthy volunteers.
    

Detailed description: 
      The primary endpoint will be assessment of the ability of the TetraGraph prototype to deliver
      neuro-stimulation, and assessment of the ability to acquire muscle action potentials and
      record these evoked responses on the SD-card. The study will be performed on healthy
      volunteers - 10 male and 10 female. Testing will be done at two separate
      stimulation/recording sites: ulnar nerve stimulation/abductor digiti minimi (ADM) muscle
      recording; and ulnar nerve stimulation/adductor pollices (AP) muscle recording. The side of
      testing (RIGHT vs. LEFT hand) will be determined a priori and randomly by the principal
      investigator, such that 10 volunteers each will be tested on the RIGHT and 10 on the LEFT
      hands. At each stimulating/recording site two stimulation protocols (single twitch
      stimulation and train-of-four stimulation) will be performed with growing current intensity
      (10-60 mA (milliAmps), in a 10 mA step-up fashion). Volunteers will rate the tolerability of
      each stimulation protocols on a visual analogue scale. EMG data will be recorded on the SD
      card and evaluated off-line.
    

Intervention name(s): Neuromuscular stimulation
Intervention type(s): Device
Intervention description(s): Single twitch and train-of-four stimulation protocols will be performed at the randomised side with growing current intensity
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: electromyography; neuromuscular blockade
Development and Validation of an Orthopedic Visit Prompt List
Condition: Musculoskeletal Diseases
MeSH terms: Musculoskeletal Diseases
Study type: Interventional

Summary: 
      Investigators are interested to see whether patients who received a visit question prompt
      list before the consultation ask more questions, feel more actively involved in their
      healthcare, and think of their surgeon as being more empathetic.
    

Detailed description: 
      Visiting a doctor with a musculoskeletal problem can be quite a daunting experience for
      patients. A visit question prompt list may help to empower patients and increase their role
      in active decision-making. Previous studies have shown that patient activation is correlated
      with a disability, pain intensity, and satisfaction with treatment. Perceived empathy is
      strongly associated with satisfaction among people with arm problems. A list that prompts
      patients to ask about things that matter to them, might improve their connection with the
      surgeon and their perceived empathy. The investigators are interested to see whether patients
      who received a visit question prompt list before the consultation ask more questions, feel
      more actively involved in their healthcare, and think of their surgeon as being more
      empathetic.
    

Intervention name(s): Prompt list
Intervention type(s): Other
Intervention description(s): The patients in the intervention group will review a prompt list before their visit.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: All new, adult (18+ years old) patients seeing an orthopedic surgeon for a consultation will be invited to enroll. Randomization will be done through an Excel random number generator. The patients in the intervention group will review a prompt list before their visit. The research assistant will shadow the surgeon to count the amount of questions they ask during their visit. Patients in both groups will fill out a survey entailing demographics, the Decisional Conflict Scale, the JSPPE, the PAM score and a satisfaction scale at the end of the visit.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Orthopedics
Neurocognitive Visual Reaction Training
Condition: Reaction Time
Study type: Interventional

Summary: 
      Incorporating neurocognitive visual reaction training has been shown to increase bating
      performance in collegiate baseball players. However, poor methodology, such as lack of a
      control group and use of an unreliable outcome measure, limit the strength of the previous
      study. Therefore the purpose of this study is to determine the effects of neurocognitive
      visual reaction training on reaction time and coordination in an athletic population.

      The purpose of this study is to determine the effects of neurocognitive visual reaction
      training on reaction time and coordination.
    


Intervention name(s): Reaction Time Training
Intervention type(s): Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Keywords: neurocognitive visual reaction training; baseball
Predictors of Success of IUI in Unexplained Infertility
Condition: Assisted Reproductive Techniques
MeSH terms: Infertility
Study type: Interventional

Summary: 
      Superovulation will be conducted with 100 mg of oral clomiphene citrate (Clomifene; Young
      Poong Pharmaceutical, Incheon, Korea) for 5 days starting on day 3 of the menstrual cycle,
      followed by daily injection of 150 IU of human menopausal gonadotropin (hMG;Menogon;
      FerringPharamceutical Co, Germany). When more than 2 dominant follicles reached a diameter of
      17 mm or the urinary specimen showed positive results for luteinizing hormone (LH) surge,
      5000 IU of hCG (Pregnyl; Organon, Oss, the Netherlands) was injected intramuscularly.
    

Detailed description: 
      Superovulation will conducted with 100 mg of oral clomiphene citrate (Clomifene; Young Poong
      Pharmaceutical, Incheon, Korea) for 5 days starting on day 3 of the menstrual cycle, followed
      by daily injection of 150 IU of human menopausal gonadotropin (hMG;Menogon;
      FerringPharamceutical Co, Germany). When more than 2 dominant follicles reached a diameter of
      17 mm or the urinary specimen showed positive results for luteinizing hormone (LH) surge,
      5000 IU of hCG (Pregnyl; Organon, Oss, the Netherlands) was injected intramuscularly.
      Successful pregnancy after IUI was confirmed by ultrasound as one or more visible gestational
      sacs in the uterine cavity.
    

Intervention name(s): Intrauterine insemenation
Intervention type(s): Device
Intervention description(s): Semen preparation processing hen intrauterine transfer after 24 hours of HCG triggering of ovulation
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: IUI; Pregnancy rate; predictors
A Study Looking at the Effectiveness, Immune Response, and Safety of a COVID-19 Vaccine in Adults in the United Kingdom
Condition: SARS-CoV-2 Infection; COVID-19
MeSH terms: COVID-19
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a study to evaluate the efficacy, immune response, and safety of a coronavirus
      disease 2019 (COVID-19) vaccine called SARS-CoV-2 rS with Matrix-M1 adjuvant in adults aged
      18-84 years in the United Kingdom. A vaccine causes the body to have an immune response that
      may help prevent the infection or reduce the severity of symptoms. An adjuvant is something
      that can make a vaccine work better. This study will look at the protective effect, body's
      immune response, and safety of SARS-CoV-2 rS with Matrix-M1 adjuvant in the study population.
      Participants in the study will randomly be assigned to receive SARS-CoV-2 rS with Matrix-M1
      adjuvant or placebo. Each participant in the study will receive a total of 2 intramuscular
      injections over the course of the study. Approximately 15,000 participants will take part in
      the study. The first approximately 400 participants who meet additional criteria will receive
      a flu vaccine, in addition to the SARS-CoV-2 rS vaccine or placebo, as part of a sub-study.

      An effort will be made to enroll a target of at least 25% of participants who are ≥ 65 years
      of age, as well as prioritizing other groups that are most affected by COVID-19, including
      racial and ethnic minorities.

      Unblinding of treatment assignment may occur in order to allow a participant to make an
      informed decision regarding receipt of an already approved or deployed SARS-CoV-2 vaccine.
      Participants who choose to receive an approved or deployed SARS-CoV-2 vaccine as per UK
      government guidance will be encouraged to remain in the study for scheduled safety
      assessments.
    


Intervention name(s): SARS-CoV-2 rS/Matrix M1-Adjuvant; Placebo; Licensed seasonal influenza vaccine
Intervention type(s): Biological; Other; Biological
Intervention description(s): Alternating intramuscular (deltoid) injections of SARS-CoV-2 rS co-formulated with Matrix-M1 adjuvant (0.5 mL) on Days 0 and 21.; Alternating intramuscular (deltoid) injections of placebo (0.5 mL) on Days 0 and 21.; Single intramuscular injection of licensed seasonal flu vaccine, administered ideally in opposite deltoid to SARS-CoV-2 rS with Matrix-M1 adjuvant or placebo injection on Day 0.
Other intervention name(s): NVX-CoV2373; Sodium chloride 0.9% (BP, sterile)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Coronavirus