bioihbjkbjnl/mcl2 huggingface dataset:
Efficacy Of Bupropion For Attention Deficit Hyperactivity Disorder (ADHD) In Adults
Condition: Attention Deficit Hyperactivity Disorder (ADHD); Substance Use Disorder (SUD)
MeSH terms: Hyperkinesis; Substance-Related Disorders; Attention Deficit Disorder with Hyperactivity
Study type: Interventional

Summary: 
      The investigators propose to conduct an open study to evaluate the efficacy and tolerability
      of Bupropion SR using clinically relevant doses in ADHD adults with a recent history of or
      current substance use disorders. We hypothesize that Bupropion SR will be effective in
      treating ADHD in this population.
    


Intervention name(s): Bupropion SR
Intervention type(s): Drug
Intervention description(s): 100mg capsules Initial dosing 100mgSR every morning, to be titrated to 200mgSR twice daily maximum
Other intervention name(s): Wellbutrin
Intervention MeSH terms: Bupropion
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Arrhythmia Prevention With an Alpha-Linolenic Enriched Diet
Condition: Atrial Fibrillation; Diet Therapy
MeSH terms: Atrial Fibrillation
Study type: Interventional
Phase: Phase 2

Summary: 
      An alpha linolenic acid (ALA) rich diet in the Lyon Diet Heart Study reduced sudden cardiac
      deaths possibly by reducing cardiac arrhythmias and ventricular fibrillation (Lancet 1994).

      Since then, there has been a growing interest in ALA, ω-3 fatty acid family precursor, as a
      cardioprotective nutrient. Much of the interest has focused on the potential antiarrhythmic
      effect of longer chain ω-3 fatty acids, DHA and EPA, derived from fish.

      We therefore concluded it important to test wether vegetable source ω-3 also had
      antiarrhythmic effects, as shown in animals by Leaf and McLennan, since this might also
      explain the beneficial effects seen on cardiovascular mortality in the Lyon Diet Heart Study.
    

Detailed description: 
      Objective: To determine the effect of an ALA rich diet in reducing recurrence of atrial
      fibrillation as a further example of a cardiac arrhythmia.

      Design: Randomized parallel design efficacy study.

      Setting: Three university hospital centers in the Bordeaux region, France.

      Patients: 98 patients randomized immediately after successful atrial fibrillation electrical
      cardioversion.

      Intervention: A canola margarine and oil, versus a conventional diet (control), with a one
      year follow-up.

      Main outcome measure: Length of time to first recurrence of atrial fibrillation.

      Significance: If ALA is antiarrhythmic, this action may explain its cardioprotective effect
      in clinical trials and cohort studies.
    

Intervention name(s): Alpha-linolenic enriched diet
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: alpha linolenic acid; atrial fibrillation; omega 3 fatty acids; diet; rapeseed oil; canola oil; cardiovascular diseases
Association Between Embryo Implantation Rate and Maternal Age
Condition: Infertility, Female
MeSH terms: Infertility; Infertility, Female
Study type: Observational

Summary: 
      To explore the relationship between maternal age and embryo implantation rate in patients
      undergoing assisted reproductive technology.
    

Detailed description: 
      The investigators designed a retrospective clinical trial conducted from January 2015 to
      December 2020 at the Reproductive Medicine Center of the Affiliated Drum Tower Hospital of
      Nanjing University Medical School. Infertility was defined as the failure of a clinical
      pregnancy after 12 months or more of regular unprotected intercourse with the same marriage
      partner. Patients experiencing infertility no younger than the age of 20 who attended the
      Reproductive Medicine Center of the Affiliated Drum Tower Hospital of Nanjing University
      Medical School for the first time and had experienced no less than one embryo transplantation
      between January 2015 and December 2019 were recruited. Patients who had experienced or
      canceled embryo transplantation cycles for any reason were excluded from this study. The gap
      year from December 2019 to December 2020 allowed researchers to follow up on the outcomes of
      pregnancies before 2020. Frozen cycles were performed when high-quality embryos existed to
      avoid unnecessary ovarian stimulation and oocyte retrieval processes. Investigators were
      blinded to the outcome of embryo transplantation, and information on pregnancy was gathered
      through telephone follow-up one year after transplantation.
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Infertile females no less than 20 years old who were attending our clinical center for the
        first time were enlisted. In total, 17394 patients suffering from primary or secondary
        infertility were enrolled in this study.
Activity in Tourette Syndrome
Condition: Tourette Syndrome; Persistent Tic Disorder
MeSH terms: Tourette Syndrome; Tic Disorders; Tics; Syndrome
Study type: Interventional

Summary: 
      Tics are brief repetitive movements or vocalizations. Gilles de la Tourette's syndrome (TS)
      is a disorder characterized by recurrent motor and vocal tics. Tourette syndrome and tic
      disorders affect up to 8% of children. Peak severity of tic disorders occurs between the ages
      of 8 to 12 years, therefore during childhood and adolescence the most significant impacts are
      felt. The quality of life of young people with tics is lower than their peers' and tic
      severity predicts lower quality of life. Studies have also shown negative social perception
      toward children with tics.

      Approximately 50% of patients with Tourette syndrome will have other diagnoses including
      attention deficit hyperactivity disorder (ADHD), obsessive compulsive disorder, anxiety and
      depression. Studies have shown improvements in ADHD with physical activity. ADHD and tic
      disorders are thought to involve the same areas of the brain; thus it is possible that tics
      might also improve with physical activity. However, no studies to date have examined this.
      The investigators predict that by implementing a motivational physical activity program, in
      conjunction with physical activity counseling, the investigators will be able to increase
      levels of physical activity in children with tics and Tourette syndrome, with a positive
      impact on tic severity.
    


Intervention name(s): Physical Activity Counselling
Intervention type(s): Behavioral
Intervention description(s): Physical Activity Counselling weekly for 8 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Tourette Syndrome; Persistent Tic Disorder; Physical Activity; Quality of Life
The Effects of Dark Chocolate (70% Cacao) on EEG Brain Waves in Vigorously Active Individuals
Condition: Healthy
Study type: Interventional

Summary: 
      The purpose of this graduate student study is to determine if ingestion of dark chocolate
      (70% cacao) will change brain frequencies between visualization at a state of rest and a
      state of exercise performance via electroencephalography (EEG) in vigorously active
      individuals.
    

Detailed description: 
      The procedures include: On day one, participants will fill out a dark chocolate Likert scale,
      physical activity assessment, and demographic questionnaire. Day two and three, on
      consecutive days will include, three EEG measurements will be recorded: 1) at baseline, 2)
      during visualization of rest for one minute, and 3) during visualization of usual vigorous
      exercise for one minute. The second day all three measurements will be recorded without dark
      chocolate (70% cacao). The third day all three measurements will be recorded again.
      Measurements 2 and 3 will be recorded savoring dark chocolate and after fully ingesting the
      dark chocolate respectively.
    

Intervention name(s): dark chocolate; non dark chocolate
Intervention type(s): Dietary Supplement; Other
Intervention description(s): Participants will be provided Parliament dark chocolate (70% cocoa) from Redlands, CA. The Parliament chocolate is made with cacao and cane sugar. Each participant will be given half a piece (1.4 g) of dark chocolate to consume for this experiment over three minutes.; No dark chocolate will be given to this group during the procedures.
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Other
Postprandial Liver and Spleen Stiffness Measurements in the Noninvasive Diagnosis of Cirrhosis
Condition: Chronic Liver Disease
MeSH terms: Liver Diseases; Fibrosis
Study type: Interventional

Summary: 
      This is a study that will evaluate the utility of measuring liver and spleen stiffness before
      and after a meal by a non invasive ultrasound based technologies called Fibroscan (Transient
      elastography) and acoustic radio-frequency impulse (ARFI) in diagnosing or excluding
      cirrhosis in patients with chronic liver disease who will be getting a liver biopsy.
    

Detailed description: 
      This is a prospective longitudinal study that will evaluate the utility of change in liver
      stiffness (LSM) and spleen stiffness measurements after a test meal in patients whom the
      diagnosis cannot be reliably ruled in or ruled out based on two measurement of LSM by TE per
      standard of care. This includes patients in whom there is discordance between clinical
      impression and LSM and/or LSM are in the grey zone (LSM between 10 and 15 kPa). Liver
      biopsy/HVPG which is performed as standard of care will be used as gold standard.
    

Intervention name(s): Fibroscan and Acoustic Radiation Force Impulse; Fibroscan; Acoustic Radiation Force Impulse
Intervention type(s): Device; Device; Device
Intervention description(s): Liver stiffness and spleen stiffness will be measured before and after a standard meal is administered by Fibroscan and Acoustic Radiation Force Impulse; Liver stiffness will be measured before and after a standard meal is administered; Liver stiffness and spleen stiffness will be measured before and after a standard meal is administered by Fibroscan and Acoustic Radiation Force Impulse
Other intervention name(s): Transient elastography
Intervention model: Single Group Assignment
Intervention model description: Cross sectional diagnostic study of Chronic liver disease patients who have had a liver stiffness measurement performed that is discordant with clinical impression either clinically the patient appears to have cirrhosis but liver stiffness measurement is less than 10 kPa or clinically there is no evidence of cirrhosis but there liver stiffness measurement is more than 15 kPa or the patients liver stiffness measurement is in the grey zone which means patients' liver stiffness measurement is between 10 and 15 kPa to investigate the utility of postprandial postprandial liver and spleen stiffness measurements in the noninvasive diagnosis of cirrhosis
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Postprandial liver and spleen stiffness measurements; Transient elastography; Cirrhosis; Acoustic radiation force impulse
High Intensity Interval Training in Chronic Stroke
Condition: Stroke
MeSH terms: Stroke
Study type: Interventional

Summary: 
      The objective of this study was to compare the effectiveness of high intensity interval
      training (HIT) and traditional aerobic training for persons with stroke.
    

Detailed description: 
      Participants were randomized to either HIT or traditional aerobic training; each 25 minutes,
      3 times per week for 4 weeks. Outcomes were measured before and after training by a blinded
      rater.
    

Intervention name(s): High-intensity interval training (HIT); Traditional Aerobic Training
Intervention type(s): Other; Other
Intervention description(s): Treadmill exercise using bursts of concentrated effort alternated with recovery periods; Moderate intensity continuous aerobic exercise on a treadmill
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Stroke; Rehabilitation; Exercise; Intensity; Gait
Genomewide Search for Loci Underlying Metabolic Syndrome
Condition: Metabolic Syndrome X; Cardiovascular Diseases; Heart Diseases; Obesity; Hypertension; Hyperinsulinism; Insulin Resistance
MeSH terms: Cardiovascular Diseases; Heart Diseases; Metabolic Syndrome; Insulin Resistance; Hyperinsulinism; Syndrome
Study type: Observational

Summary: 
      To identify the genes involved in the metabolic syndrome.
    

Detailed description: 
      BACKGROUND:

      Metabolic syndrome, characterized by clustering of multiple metabolic abnormalities including
      abdominal obesity, dyslipidemia, hyperinsulinemia, hyperglycemia, and hypertension, is one of
      the most important risk factors for cardiovascular disease and stroke. Genetics play a
      significant role in determining the individual susceptibility to metabolic syndrome and the
      inter-individual variation in its associated phenotypes, though these genetic factors remain
      largely unknown. The long-term goal is to identify the metabolic syndrome susceptibility
      genes and their functional variants.

      DESIGN NARRATIVE:

      The goal of the research is to study the underlying phenotypic structure of the metabolic
      syndrome and to systematically search for genetic loci predisposing to the metabolic syndrome
      using the genome scan approach. The specific aims are: (1) to screen about 10,000 sibling
      pairs aged 40 to 64 years in Anqing, Anhui China, on intermediate phenotypes of the metabolic
      syndrome including body mass index, waist and hip circumference, serum lipid profiles
      (triglyceride, HDL-, LDL-, and total cholesterol), fasting serum glucose and insulin level,
      and blood pressure; (2) to study the underlying phenotypic structure of the metabolic
      syndrome in the about 10,000 ascertained sibling pairs using factor analysis; (3) to select
      and genome scan 800 nuclear families from the pool of the ascertained sibling pairs using
      Weber screening set 10 markers. Each selected nuclear family contains a "proband" and >=3
      other family members. The values of the three most significant factors for metabolic syndrome
      in the factor analysis (see specific aim 2) will be used to classify "proband" status for
      each subject. A "proband" is defined as having >=2 out of 3 factor values falling into the
      same side of the 10/90 percentile tails of the corresponding age- and sex-adjusted population
      distributions; (4) to test for linkage in the genome-scanned families on intermediate
      phenotypes and factors of metabolic syndrome using the Unified Haseman-Elston method. In
      addition to the univariate test, linkage analysis will be performed using a novel
      multivariate version of the Unified H-E method, which has recently been proposed and shown to
      be significantly more powerful than the univariate test for traits with common genetic
      determinants; (5) to perform expansion or replication linkage studies on loci identified in
      the genome scan in 300-400 additional families with >=1 proband with a denser set of markers.
Effects of Remifentanil Infusion on Emergence Delirium After Dental Surgery in Children
Condition: Emergence Delirium
MeSH terms: Delirium; Emergence Delirium
Study type: Observational

Summary: 
      In this study, the investigators tried to show the effect of remifentanil on emergence
      delirium caused by sevoflurane used in general anesthesia.We planned a retrospective study.
      We formed two groups of 80 participants. One group included patients who were received
      remifentanil infusion during general anesthesia.The other group included patients who were
      received only sevoflurane inhalation anesthesia.

      The patients included in the study were evaluated for emergence delirium in the postoperative
      period be evaluating the past recorded informations.
    


Intervention name(s): The Paediatric Anaesthesia Emergence Delirium scale assesment which was recorded postoperatively
Intervention type(s): Other
Intervention description(s): routine remifentanil infusion during general anesthesia
Intervention MeSH terms: Anesthetics
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        All patients between 2 and 6 years old having American Society of Anesthesiologists score
        1-2.
Efficacy and Safety of BI 1356 in Combination With Metformin in Patients With Type 2 Diabetes
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 3

Summary: 
      The objective of the current study is to investigate the efficacy, safety and tolerability of
      BI 1356 (5.0 mg daily) compared to glimepiride given for 104 weeks as add-on therapy to
      preferably > 1500 mg metformin in patients with type 2 diabetes mellitus with insufficient
      glycaemic control
    


Intervention name(s): Placebo identical to BI 1356 5mg; Placebo identical to Glimepiride 1mg or 2mg or 3mg or 4 mg; BI 1356; Glimepiride
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Placebo tablet once daily; Placebo tablets once daily; 5mg, once daily in the morning for 104 weeks; 1mg or 2mg or 3mg or 4mg in the morning for 104 weeks
Intervention MeSH terms: Glimepiride; Linagliptin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Efficacy and Safety of Palonosetron Hydrochloride in the Prevention of Nausea and Vomiting
Condition: Neoplasms; Chemotherapy-Induced Nausea and Vomiting
MeSH terms: Nausea; Vomiting
Study type: Interventional
Phase: Phase 4

Summary: 
      This purpose of this study is to evaluate the efficacy and safety of single and repeated
      doses of palonosetron hydrochloride in preventing nausea and vomiting caused by moderate and
      highly emetogenic chemotherapy in patients.
    

Detailed description: 
      Group I (Highly Emetogenic Chemotherapy): Patients that accepted chemotherapy including
      Cisplatin≥50mg/m2, Carmustine>250mg/m2, Cyclophosphamide>1500mg/m2, Dacarbazine>60mg/m2,
      Doxorubicin>60mg/m2, Epirubicin>90mg/m2, IFO≥10g/m2 or AC program.

      Group II (Moderately Emetogenic Chemotherapy): Patients that accepted chemotherapy including
      any dose of Carboplatin, Daunorubicin, Oaliplatin, Irinotecan, or Doxorubicin<60mg/m2(not
      include liposomal doxorubicin), Epirubicin≤90mg/m2, Carmustine≤250mg/m2,
      Methotrexate≥250mg/m2, Cyclophosphamide≤1500mg/m2, Arabinoside>200mg/m2, IFO<10g/m2,
      Cisplatin≥50mg/m2.

      Total subjects: 1000, single dose of palonosetron group of 500 patients, repeated doses of
      palonosetron group of 500 patients. According to the study subjects receiving highly
      emetogenic chemotherapy or moderately emetogenic chemotherapy, subjects are stratified
      randomize.
    

Intervention name(s): Palonosetron Hydrochloride; Palonosetron Hydrochloride
Intervention type(s): Drug; Drug
Intervention description(s): 0.25 mg IV*1 dose on day 1, 30 minutes prior to the administration of the major chemotherapeutic agent.; 0.25mg IV*3 doses on days 1,3 and 5,30 minutes prior to the administration of the major chemotherapeutic agent.
Intervention MeSH terms: Palonosetron
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
5HT3 Antagonism and Auditory Gating in Schizophrenia
Condition: Schizophrenia
MeSH terms: Schizophrenia
Study type: Interventional

Summary: 
      The target groups in this study are brain waves and neurotransmitters (chemical messengers)
      in the brain. Subjects with diagnosed with schizophrenia will be studied. The study will help
      understand more about normal brain functioning and how that functioning differs in people
      with schizophrenia. Another purpose of this study is to determine how the altered brain
      functioning in schizophrenia contributes the symptoms found in the illness.
    


Intervention name(s): ondansetron; neuropsychological testing; nicotine; haloperidol
Intervention type(s): Drug; Behavioral; Drug; Drug
Intervention MeSH terms: Haloperidol; Ondansetron; Haloperidol decanoate; Nicotine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double
Primary purpose: Treatment
Keywords: schizophrenia; ondansetron; nicotine; haloperidol
Effect of Carnosine on Diabetes and Cardiovascular Risk Factors
Condition: Metabolic Diseases, Type 2 Diabetes, Cardiovascular Disease
MeSH terms: Cardiovascular Diseases; Diabetes Mellitus; Metabolic Diseases
Study type: Interventional

Summary: 
      Carnosine is a naturally occurring compound with a potential health benefits. In animal
      studies, carnosine supplementation reduces manifestation of chronic civilization diseases,
      regulates subclinical inflammation, protein glycation and lipid & glucose metabolism. Our
      preliminary data showed the relationship between insulin resistance and carnosine content in
      human skeletal muscle. Based on these unique results we plan to perform intervention study
      aimed at identifying effects of carnosine on insulin sensitivity and secretion, which might
      reduce the development of T2D in obese. Similar metabolic effects of vitamin D3 were
      associated with expression of specific miRNAs. Circulating miRNAs related to carnosine action
      are unknown. The putative positive effects of carnosine on insulin sensitivity and secretion
      in obese patients might have a tremendous impact in prevention of type 2 diabetes.
      Identification of miRNAs associated with carnosine action could provide predictors of
      successful therapy.
    


Intervention name(s): Carnosine
Intervention type(s): Dietary Supplement
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Basic Science