Analysis of Parameters Indicating the Intensity of Suicidal Behavior in Psychiatric Patients
Condition: Suicidal Behaviour; Cognitive Functions Confusion
MeSH terms: Confusion
Study type: Observational

Summary: 
      The aim of this study was to analyse the level of cognitive functioning of patients with
      history of suicidal behaviour suffering from depression and schizophrenia, and to evaluate
      their oxidative stress parameters and selected biochemical parameters on the basis of
      bloodwork.
    

Detailed description: 
      The study was conducted among 120 patients hospitalized in the Department of Psychiatry of
      the UMB (Medical University of Białystok). Every participant gave their own voluntary and
      informed written consent. Blood parameters tests were performed in the Diagnostic Laboratory
      of the University's Clinical Hospital and in the Department of Hygiene, Epidemiology and
      Ergonomics of the Medical University of Białystok. In the first stage of the study, an
      M.I.N.I. 7.0.2 interview was conducted with each patient to verify the intensification of
      suicidal behaviour. Based on the scores, the patients were classified into one of eight
      groups: no suicidal behaviour group (G0K, G0M); group experiencing suicidal thoughts without
      a tendency of implementation (G1K, G1M); group experiencing suicidal thoughts with a tendency
      of implementation (G2K, G2M); group after a suicide attempt (G3K, G3M).The second stage of
      the study consisted of biochemical blood tests, where concentrations of vitamin D3, B12,
      folic acid, sodium, potassium, calcium, magnesium, chlorine, total cholesterol, LDL and HDL
      fractions, TG and metabolites of the oxidative stress pathway were determined. The following
      concentrations were determined: dityrosine (AUF/mg protein), TOS (nmol H2O2 Equiv/mg
      protein), TAC (umol/mg protein), OSI (TOS/TAC ratio), FRAP (μmol/mg protein), GPx (mU/mg
      protein), SOD (mU/mg protein) CAT (nmol H2O2/min/mg protein), AOPP (nmol/mg protein), NO
      (nmol/mg protein), GSH (μg/mg protein). The third stage of the study consisted of the
      participants completing a CogState computerized test to verify their cognitive functioning.
      The following cognitive functions were assessed: psychomotor drive (DET), metastability of
      attention (IDN), verbal memory, retrieval of learned material (ISLR) and verbal learning and
      memory (ISL), visual learning and memory (OCL), processing speed (GMCT), visual memory
      including deferred retrieval (GMR), executive functions (SETS and GML), working memory (ONB,
      TWOB).
    

Intervention name(s): Interview questionnaire; biochemical parameters; cognitive function
Intervention type(s): Other; Diagnostic Test; Diagnostic Test
Intervention description(s): An Interview questionnaire concerning an assessment of the intensity suicidal behavior, M.I.N.I. 7.0.2 was used.
M.I.N.I. interview was conducted with each patient to verify the intensification of suicidal behaviour.; The concentrations of the following parameters were determined from the:
blood serum: vitamin D3, B12, folic acid, sodium, potassium, calcium, magnesium, chlorine, total cholesterol, LDL and HDL fractions, TG
plasma: metabolites of the oxidative stress; The participants completing cognitive function were assessed using computer CogState Test. The following cognitive functions were assessed: psychomotor drive (DET), metastability of attention (IDN), verbal memory, retrieval of learned material (ISLR) and verbal learning and memory (ISL), visual learning and memory (OCL), processing speed (GMCT), visual memory including deferred retrieval (GMR), executive functions (SETS and GML), working memory (ONB, TWOB).
Observational model: Case-Crossover
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        The research included 120 people (58 women and 62 men) who met the criteria for being
        incluted in the study and who did not possess exclusion criteria.
      
Keywords: depression; schizophrenia; biochemical blood tests; oxidative stress pathway