bioihbjkbjnl/mcl2 huggingface dataset:
Efficacy of an Antiage Aesthetic Treatment for the Middle and Inferior Third of the Face
Condition: Face Skin Laxity
MeSH terms: Cutis Laxa
Study type: Interventional

Summary: 
      Primary endpoint of the study is to evaluate clinically and by non-invasive instrumental
      evaluations the aesthetic performance, on the third middle and inferior of the face, of
      "MonoDermà HA Bio-revitalizing gel", an intradermal filler containing hyaluronic acid,
      combined to a low level laser therapy (LLLT) to obtain a stable photo-cross-linking effect
      inside the dermis.
    


Intervention name(s): MonoDermà HA gel combined to a low level laser
Intervention type(s): Device
Intervention description(s): Two intradermal injections of the filler were performed during the basal and after 1 month, on the middle and inferior third of the face (1ml for each face side) using a needle (30G).
Immediately after both injection procedures, LLLT session were performed on the same face area for a total of 8 minutes, using three different wavelengths (450 nm, 650 nm and 1064 nm) simultaneously.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Oxytocin and Learning for Teaching
Condition: Social Psychology
Study type: Interventional
Phase: Early Phase 1

Summary: 
      One well-established cognitive theory propose a divide between social and non-social (i.e.,
      cognitive) systems. However, recent work suggests that traditionally social systems can be
      utilized to enhance cognitive performance. In this study the investigators aim to explore
      this cooperation between oft-competing systems by instructing participants to learn
      information because they will be subsequently tested (the nonsocial learning-for-testing
      condition), or because they will be teaching the information to someone else (the prosocial
      learning-for-teaching condition). This latter condition relies upon the mentalizing system,
      which is used to contemplate another person's mental state, rather than traditional memory
      systems. This implies that the mnemonic powers of the mentalizing system can be leveraged in
      the learning of a broad array of non-social topics. Furthermore, there is also an emerging
      literature on the role of oxytocin, a neuropeptide naturally produced in the hypothalamus, in
      memory that parallels the social/nonsocial split. Oxytocin may benefit the
      learning-for-teaching group both in terms of enhancing initial social motivation and
      efficient use of the mentalizing system and then also in terms of memory consolidation for
      this information learning under socially-motivated conditions.

      The investigators expect to replicate the basic learning-for-teaching effect such that those
      in the teaching condition will remember more than those in the testing conditions. They also
      expect an interaction between oxytocin administration and learning condition such that
      oxytocin administration should enhance learning for socially-motivated learning exclusively.
    


Intervention name(s): Intranasal oxytocin; Intranasal placebo
Intervention type(s): Drug; Drug
Intervention description(s): Through the use of 1oz bottles attached with metered nasal pumps (1 puff = .1ml), participants will self-administer 24 IU oxytocin (Syntocinon, Novartis Pharmaceuticals). 5 puffs per nostril (1 puff = 2.4 IU oxytocin).; Through the use of 1oz bottles attached with metered nasal pumps (1 puff = .1ml), participants will self-administer 5 puffs per nostril. Placebo consists of: 2 mls Glycerine and 3 mls purified water (methylparaben and propylparaben mixed according to purified water formula) for a total of 5 ml, which will be filtered with a 5mu filter.
Other intervention name(s): Syntocinon nasal spray
Intervention MeSH terms: Oxytocin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: oxytocin; healthy sample; intranasal administration; learning
Pharmacological Profile of Different Berberine Formulations, and Effects on Blood Sugar Levels
Condition: Pharmacokinetics
Study type: Interventional

Summary: 
      The primary objective of this study is to evaluate the gastrointestinal absorption of
      berberine (hydrochloride) in a novel formulation in healthy adult volunteers by comparing it
      with free berberine (hydrochloride) formulation. Several pharmacokinetic parameters are
      compared.

      As secondary objective, the immediate or short-term effects of Berberine supplementation on
      blood sugar levels in healthy volunteers are evaluated via a glucose tolerance test (OGTT)
      using a portable glucometer.
    


Intervention name(s): Berberine LipoMicel; Regular Berberine hard-gels
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Berberine LipoMicel® soft-gels. Total dose of 500 mg of berberine; Total dose of 500 mg of berberine
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Bioavailability; Berberine; LipoMicel; Pharmacokinetics
Short-term Outcomes of Transanal Total Mesorectal Excision With Structured Training Curriculums in China
Condition: Rectal Cancer
MeSH terms: Rectal Neoplasms
Study type: Observational

Summary: 
      Transanal total mesorectal excision (TaTME) is an alternative for mid-low rectal cancer. In
      China, this procedure has been performed in high-volume centers with structured training
      curriculums. This study aimed to evaluate the short-term outcomes during the initial
      implementation of the TaTME procedure in high-volume centers who followed structured training
      curriculums in China.
    


Intervention name(s): Procedure/Surgery
Intervention type(s): Other
Intervention description(s): Transanal Total Mesorectal Excision
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        rectal cancer
Comparison of Videolaryngoscopy and Direct Laryngoscopy in Pediatric Airway Management
Condition: Airway Management; Videolaryngoscopy
Study type: Interventional

Summary: 
      The investigators intended to evaluate first success rate and learning curve of trainee
      anesthetists performing direct and videolaryngoscopy in pediatric airway management.
    

Detailed description: 
      After obtaining written informed consent of 10 trainee anesthetists with non less than 24
      months and not exceeding 60 months residency, use of the King Vision aBlade videolaryngoscope
      was demonstrated by presenting a 2 min instruction video. First endotracheal intubation by
      each trainee anesthetist was randomly allocated to either direct (DL) or King Vision aBlade
      videolaryngoscopy (KingVL). Then order of laryngoscopy type was alternating at least each
      trainee anesthetists performed 10 DL and 10 KingVL endotracheal intubations.
    

Intervention name(s): King Vision aBlade; direct laryngoscopy
Intervention type(s): Device; Device
Intervention description(s): endotracheal intubation performed with King Vision aBlade; endotracheal intubation performed with direct laryngoscopy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Care Provider)
Primary purpose: Basic Science
Keywords: pediatric airway management; learning curve
Vascular Impairment in Type II Diabetes Mellitus With Co-morbid Obstructive Sleep Apnea
Condition: Sleep Apnea, Obstructive; Diabetes Mellitus
MeSH terms: Apnea; Sleep Apnea Syndromes; Sleep Apnea, Obstructive; Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 2

Summary: 
      The investigators will examine the possible synergistic effects of obstructive sleep apnea
      (OSA) and type II diabetes mellitus (DM) on vascular functioning by performing a two-part
      investigation:

        -  A cross-sectional study comparing subjects with OSA+DM, OSA only, DM only, and healthy
           controls.

        -  A three-month randomized placebo-controlled trial of continuous positive airway pressure
           (CPAP) in subjects with OSA+DM.
    


Intervention name(s): Continuous positive airway pressure; Sham continuous positive airway pressure
Intervention type(s): Device; Device
Intervention description(s): CPAP at therapeutic pressure; ResMed S9 device in fixed pressure mode (Sydney, Australia).; CPAP at non-therapeutic pressure; ResMed S9 device using a ResMed sham mask (Sydney, Australia).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Revascularisation of Autotransplanted Teeth
Condition: Endodontic Disease; Pulp Canal Obliteration
MeSH terms: Dental Pulp Diseases
Study type: Interventional

Summary: 
      Retrospective Analysis of a Study cohort that experienced autotransplantation of mature teeth
      with simultaneous root end resection

      Note: The study was registered on Clinicaltrials.gov after termination of study.
    


Intervention name(s): Autotransplantation and Apicoectomy
Intervention type(s): Procedure
Intervention description(s): Autotransplantation of a mature teeth with simultaneous extra-oral root-end resectoin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Autotransplantation, Apicoectomy, Revascularisation
Vitamin C to Reduce Morning Cardiovascular Risk
Condition: Cardiovascular Risk Factor
Study type: Interventional

Summary: 
      This study will test the efficacy of Vitamin C to counteract morning cardiovascular (CV) risk
      markers in a randomized, double blind, placebo controlled crossover pilot study. The
      participants will also perform morning typical behaviors such as arousal from sleep, change
      in posture (getting out of bed) and mild intensity physical activity; identical to the
      stressors encountered in everyday life. Primary dependent variables are markers of
      cardiovascular risk including vascular endothelial function and oxidative stress.
    

Detailed description: 
      The investigators plan to test the efficacy of Vitamin C to counteract morning cardiovascular
      (CV) risk markers in a randomized, double blind, placebo controlled crossover pilot study.
      The participants will also perform morning typical behaviors such as arousal from sleep,
      change in posture (getting out of bed) and mild intensity physical activity; identical to the
      stressors encountered in everyday life. This pilot study is in healthy middle aged adults
      without a history of CV disease.

      Participants will spend two nights in an inpatient hospital suite at Hatfield Research
      Center. Upon awakening in the morning, they will either ingest Vitamin C or placebo in a
      randomized order. This will be followed by moderate intensity exercise, recovery, and
      discharge.
    

Intervention name(s): Vitamin C; Placebo
Intervention type(s): Dietary Supplement; Other
Intervention description(s): 1.5g Ascorbic Acid; Inactive placebo to mimic 1.5g ascorbic acid.
Other intervention name(s): Ascorbic Acid
Intervention MeSH terms: Ascorbic Acid
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Sleep; Vitamin C
Study of Relationship Between Changes in Inflammation, Lung Function, Symptoms and Medication Use in COPD Patients
Condition: Pulmonary Disease, Chronic Obstructive
MeSH terms: Lung Diseases; Pulmonary Disease, Chronic Obstructive
Study type: Observational

Summary: 
      The intention with the study is to have a better understanding of what happens to COPD
      patients' symptoms, lung function and markers of inflammation over 12 weeks. This information
      will increase the understanding of COPD and how to design new treatments for COPD in the
      future.
    

Detailed description: 
      This is a Phase IV, open-label, single-arm, single-site study. The purpose of this
      exploratory study is to gain longitudinal insights into the relationships between the
      inflammatory profile, symptoms, lung function, and reliever use in subjects with chronic
      obstructive pulmonary disease (COPD).

      The study will include a minimum of 8 clinic visits and consist of a Screening Visit (Visit
      1), a 4-week run-in period, a Baseline Visit (Visit 2) and a 12-week observational period,
      including 6 visits scheduled every 2 weeks. To standardise the use of COPD medications all
      subjects will receive maintenance Duaklir and reliever Ventolin for the duration of the
      study. During the observational period, additional visits may occur if subjects experience a
      worsening of their COPD symptoms. For each individual subject, the duration of participation
      in the study will be 16 weeks.

      Estimated study duration is approximately 20 months including approximately 50 patients.
    

Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        The study will include patients diagnosed with symptomatic COPD and blood eosinophil count
        >0.1×109 cells/L, who are receiving maintenance treatment with a long-acting β2 agonist
        (LABA) in combination with ICS and/or a long-acting muscarinic antagonist (LAMA) and
        require use of an inhaled short-acting bronchodilator (β2 agonists or anticholinergics) as
        rescue medication. The study will include both current and former smokers (with at least 10
        pack-year history) and intends to recruit a maximum of 30% current smokers.
      
Biospecimen description: 
      Serum, plasma, sputum, nasal and urine samples will be collected for exploratory research.

      Blood samples will be collected for future genetic/DNA research.
    
Keywords: Chronic Obstructive Pulmonary Disease, COPD
The Effect of Deep Friction Massage on the Achilles Tendon Blood Flow
Condition: Healthy Situation
Study type: Interventional

Summary: 
      Background: There is a hypothesis in literature that the mechanical action of deep transverse
      friction massage (DTF) produces vasodilatation and increases blood flow. But as yet, no
      experimental study has confirmed the effect of DTF on blood flow in the Achilles tendon.
      Objective: The purpose of the present study was to investigate whether one session of DTF can
      influence the Achilles tendon blood flow.

      Design: a randomized pre- posttest trial was set up. Patients: Sixty-two healthy participants
      volunteered. Each person underwent the following four steps of the procedure: 1. Measuring
      the tendon blood flow (PRE), 2.fifteen minutes of DTF on the Achilles tendon, 3. Measuring of
      the tendon blood flow (POST), 4.follow - up measurement after 20 minutes of rest (POST20).

      Intervention: one leg of each person was randomly assigned to deep transverse friction
      session, the other leg was used as a control leg. Friction was applied continuously for a
      total of 15 minutes. Measurements: the microcirculation was determined at 2 and 8 tissue
      depths at the distal and the proximal midportion of the Achilles tendon. For each level, the
      capillary blood flow, the tissue oxygen saturation, and the postcapillary venous filling
      pressure was registered.
    


Intervention name(s): deep transverse friction massage
Intervention type(s): Other
Intervention description(s): For the application of the deep transverse friction massage, the participants were positioned supine with the ankle in 90 ° of dorsiflexion, in order to bring some tension on the tendon. The treating clinician stabilized the subject's foot with one hand while applying the DTF with the other hand. The deep friction massage is a pinching technique with thumb and index finger, reinforced by the middle finger.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Effects of Atorvastatin on Endothelial Progenitor Cells After Coronary Surgery
Condition: Coronary Artery Bypass Surgery; Elective Surgical Procedure
Study type: Interventional
Phase: Phase 4

Summary: 
      Experimental data have demonstrated favourable effects of statins on endothelial progenitor
      cell (EPC) mobilization from the bone marrow, and cardiac homing. The purpose of the present
      prospective randomized controlled trial is to determine the effects of aggressive
      atorvastatin treatment (40 mg daily 2-weeks prior to surgery) on the number of endothelial
      progenitor cells (EPCs) after cardiopulmonary bypass by comparing with placebo.
    

Detailed description: 
      Endothelial progenitor cells, a subgroup of hematopoietic stem cells have a significant role
      in vascular homeostasis. In animal models of ischemia, endothelial progenitor cells are
      rapidly incorporated into sites of neovascularization, have the potential to induce and
      augment vasculogenesis/ angiogenesis, prevent cardiomyocyte apoptosis in peri-infarct
      regions, and reduce adverse remodeling. Treatment with atorvastatin has been shown to
      increase endothelial progenitor cell count in patients with coronary artery disease.
      Therefore, we will investigate whether atorvastatin augments the number of endothelial
      progenitor cells after cardiopulmonary bypass in patients undergoing coronary artery bypass
      surgery (CABG). Thus, we conducted a randomized double-blind, placebo-controlled, 2-way
      parallel trial in 60 patients undergoing coronary artery bypass surgery. Patients will
      receive either 2-week treatment with atorvastatin or placebo prior to surgery. Endothelial
      progenitor cells will be quantitated by flow cytometric phenotyping obtained from peripheral
      blood samples. In addition, cardiac markers (CK-MB mass, cardiac troponin-I), biochemical
      profile, liver function tests, high sensitive C-reactive protein (hsCRP) and coagulation
      profile will be determined at 4 time points: 1) preoperatively (baseline); 2) 6 hours after
      the end of cardiopulmonary bypass; 3) 24 hours after surgery; 4) 5th days postoperatively.
      Clinical, operative characteristics, cardiac markers, high sensitive C-reactive protein and
      endothelial progenitor cell count will be compared between the groups. Adverse outcomes will
      also be noted and reported.
    

Intervention name(s): Atorvastatin; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 40mg/day once daily for two weeks prior to surgery; 1tb/day once daily for two weeks prior to surgery
Other intervention name(s): Ator; Placebo tablets matched to atorvastatin
Intervention MeSH terms: Atorvastatin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Endothelial progenitor cells; Atorvastatin; Coronary surgery
Neurobiology of Eating Disorders Treatments
Condition: Anorexia Nervosa; Bulimia Nervosa
MeSH terms: Anorexia; Bulimia; Feeding and Eating Disorders; Anorexia Nervosa; Bulimia Nervosa
Study type: Interventional

Summary: 
      Background. Treatments of eating disorders result too often in partial psychological and
      physical remission, chronic course, dropout, relapse and death, with no fully known
      explanations for this failure. In order to clarify this problem, we conducted a three
      branches study to identify the biochemical background of cognitive-behavioral psychotherapy
      (CBT), individual psychology brief psychotherapy (IBPP), and psychotherapy-pharmacotherapy
      with CBT+olanzapine in anorexics (AN) and bulimics (BN) by measuring the levels of plasma
      homovanillic acid (HVA) for dopamine secretion, plasma 3-methoxy-4-hydroxy-phenylglycol
      (MHPG) for noradrenalin secretion, and platelet [3 Hydrogen]-Paroxetine-binding Bmax and Kd
      for serotonin transporter function. The data were then compared with psychopathological and
      physical alterations. Methods. Branch 1 investigated the effects of 4 months of CBT on plasma
      HVA, MHPG and [3 Hydrogen]-Par-binding in 14 AN-restricted, 14 AN-bingeing/purging, and 22 BN
      inpatients. Branch 2 investigated the effects of 4 months of IBPP on plasma HVA in 15 AN and
      17 BN outpatients. Branch 3 investigated the effect of 3 months of CBT+olanzapine (5 mg/day)
      in 30 AN outpatients. The data are analyzed using one-way ANOVA for repeated measures for the
      changes between basal and post-treatment biological and psychological parameters, two-way
      ANOVA for repeated measures for the differences in the psychobiological data in the 3 groups,
      Spearman's test for the correlations between basal and final changes in the psychological and
      biological scores.
    


Intervention name(s): CBT (Cognitive Behavioral Therapy); IBPP (individual psychology brief psychotherapy); CBT + OLANZAPINE; nutritional rehabilitation; delorazepam
Intervention type(s): Behavioral; Other; Drug; Dietary Supplement; Drug
Intervention description(s): It is a worldwide known form of psychotherapy for eating disorders; It is a worldwide known form of psychotherapy for eating disorders; It is a worldwide known form of psychotherapy for eating disorders associated with a new antipsychotic with good efficacy on anorexia nervosa; all patients were followed-up monthly with nutritionist and dietitian visits; all patients were followed-up with psychiatric visits with symptomatic drug administration (tranquillizer: delorazepam) where necessary
Other intervention name(s): B-APP: brief adlerian psychodynamic psychotherapy
Intervention MeSH terms: Chlordesmethyldiazepam; Olanzapine
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Comparison of Colesevelam Hydrogen Chloride (HCl) Powder For Oral Suspension Versus Generic Cholestyramine Through Use of the Bile Acid Sequestrant Acceptability (BASA) Scale
Condition: Healthy
Study type: Interventional
Phase: Phase 4

Summary: 
      The objective of this study is to compare the acceptability of Colesevelam HCl powder for
      oral suspension versus generic cholestyramine via the BASA scale, based upon an anticipated
      equivalent cholesterol lowering doses of each comparator drug.
    

Detailed description: 
      In 2009, colesevelam HCl was approved as a powder formulation. Little objective evidence
      exists comparing the acceptability of colesevelam HCl powder for oral suspension formulation
      versus other bile acid sequestrant powder formulations. A Bile Acid Sequestrant Acceptability
      (BASA) Scale was developed and validated as an instrument to compare the acceptability of
      different bile acid sequestrant preparations
    

Intervention name(s): Cholestyramine; Colesevelam HCl
Intervention type(s): Drug; Drug
Intervention description(s): Cholestyramine 12 grams, one time dose; Colesevelam HCl, 4 grams, one time dose
Other intervention name(s): Questran; Welchol
Intervention MeSH terms: Colesevelam Hydrochloride; Cholestyramine Resin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Bile Acid Sequestrant; Resin; Lipids; Glucose; Cholesterol; Diabetes Mellitus; Bile Acid Sequestrant Acceptability Scale