Comparison of Efficacy of Naproxen Versus Ibuprofen
Condition: Pain, Postoperative
MeSH terms: Pain, Postoperative
Study type: Interventional
Phase: Phase 4

Summary: 
      Comparison between Naproxen and Ibuprofen in management of post operative endodontic pain was
      done.Total 116 patients were selected and divided in to two groups.One group was given
      Naproxen and other was given Ibuprofen.
    

Detailed description: 
      This Randomized Controlled Trial was carried out in Outpatient Department of Operative
      Dentistry, Fatima Memorial Hospital, Lahore, Pakistan and was completed in six months from
      September 2nd,2019 to February 25th,2020. Sample size of 116 cases(58 in each group) of
      irreversible pulpitis was calculated with 80% power of test, 5% level of significance,
      P1(prevalence) for naproxen was 61.53% and P2 for ibuprofen is 38.46%. Estimation of P
      (prevalence) as 90% is based on pilot study carried in our Department. The patients were
      randomly allocated into two groups, A and B, by random number table. In both groups teeth
      were anaesthetized using 1.8ml of 2% lignocaine containing 1:100,000 epinephrine and isolated
      with rubber dam. An access cavity was prepared with round bur and pulpectomy was done using
      hand files. Working length was determined using an electronic apex locator and confirmed with
      periapical radiograph. Canals were prepared with step back technique. Canals were then dried
      with paper points and the access cavities were restored temporarily with cavit(Cavit3M
      ESPE).Visual analogue scale for pain score was measured for both groups before initial
      endodontic procedure . group A was given (naproxen 550 mg B.D), while group B was given
      (Ibuprofen 400mg B.D).Post-operative pain was measured subjectively after 24 hours with
      standard Visual Analogue Score (VAS) scored on a 10 cm scale, with markings at every 1 cm
      anchored by the end points of "no pain" on the left and "worst pain" on the right. Patient
      were asked to point the number most precisely describing the amount of pain he or she
      experienced after 24 hours. All this data was recorded in a specially designed proforma
      (attached).Efficacy was labelled as per operational definitions. Data was analyzed using SPSS
      version 20. For descriptive analysis, mean and standard deviation were reported for age, BMI
      and VAS score, whereas frequency and percentages were calculated for categorical variables
      like gender and educational status. A chi square was used to determine the significance of
      the difference between the efficacy of naproxen and ibuprofen. Data was stratified for age,
      gender, BMI and educational status .This comparison also included feelings of patients in
      terms of side effects. A p value 0.05 or less was taken as significant. Post stratification
      chi-square was applied with p value ≤0.05 considered as significant.
    

Intervention name(s): Comparison of Efficacy of Naproxen versus Ibuprofen
Intervention type(s): Drug
Intervention description(s): Comparison of Efficacy of Naproxen Versus Ibuprofen in the Management of Post-Operative Endodontic Pain in Teeth with Irreversible Pulpitis
Intervention MeSH terms: Ibuprofen; Naproxen
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Supportive Care