The Effects of CO2 Pneumoperitoneum at Different Temperature in Laparoscopic Surgery
Condition: Benign Neoplasm of Cervix Uteri; Gynecological Laparoscopy
MeSH terms: Neoplasms; Uterine Cervical Neoplasms; Pneumoperitoneum
Study type: Interventional

Summary: 
      Objective: It is recommended to heat and humidify CO2 in laparoscopic surgery to prevent
      postoperative pain and hypothermia but information about its effects on hemodynamic and
      respiratory parameters is limited. The investigators aimed to investigate the effects of
      standard and heated-humidified CO2 on hemodynamic and respiratory parameters.

      Study design: One hundred patients who underwent laparoscopic hysterectomy for benign
      pathology were divided into two groups: Group CD (cold-dry) patients were administered
      standard CO2, while Group HH (heated-humidified) patients were administered 95% humidified
      insufflation at 37°C. Hemodynamic and respiratory parameters, body temperature, pain score
      and blood count parameters were recorded.
    

Detailed description: 
      The sample consisted of 100 American Society of Anesthesiologists (ASA) physical status I-II
      patients aged 40-65 who underwent laparoscopic hysterectomy for benign pathology. The
      patients were divided into two groups according to a randomization scheme created by a
      computer: Group CD (cold-dry) patients were administered dry CO2 via insufflator at room
      temperature (21°C), while Group HH (heated-humidified) patients were administered 95%
      humidified CO2 insufflation at 37°C. The study was planned as a randomized and double-blind
      study, where patients were not informed of their group.During the operation and in the
      postoperative period, the patients were followed up by two different anesthetists. All
      patients were given information and training on the anesthesia method, the use of the
      patient-controlled-analgesia (PCA) device and the visual analog scale (VAS) the day before
      the operation. The patients' demographic data (age, weight, height, etc.) and their basal
      systolic, diastolic and mean blood pressures and heart rates were measured prior to the
      operation and recorded on the case report form.
    

Intervention name(s): Group HH (heated-humidified)
Intervention type(s): Procedure
Intervention description(s): Group CD patients were administered dry CO2 via insufflator at room temperature (21°C), while Group HH patients were administered 95% humidified CO2 insufflation at 37°C. The study was planned as a randomized and double-blind study, where patients were not informed of their group. During the operation and in the postoperative period, the patients were followed up by two different anesthetists. All patients were given information and training on the anesthesia method, the use of the patient-controlled-analgesia device and the visual analog scale the day before the operation. The patients' demographic data (age, weight, height, etc.) and their basal systolic, diastolic and mean blood pressures and heart rates were measured prior to the operation and recorded on the case report form. Both groups received the standard general anesthesia protocol. Laparoscopic surgery was performed in the same manner for all cases by AA.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The patients were divided into two groups according to a randomization scheme created by a computer: Group CD (cold-dry) patients were administered dry CO2 via insufflator at room temperature (21°C), while Group HH (heated-humidified) patients were administered 95% humidified CO2 insufflation at 37°C. The study was planned as a randomized and double-blind study, where patients were not informed of their group. During the operation and in the postoperative period, the patients were followed up by two different anesthetists. All patients were given information and training on the anesthesia method, the use of the patient-controlled-analgesia (PCA) device and the visual analog scale (VAS) the day before the operation. The patients' demographic data (age, weight, height, etc.) and their basal systolic, diastolic and mean blood pressures and heart rates were measured prior to the operation and recorded on the case report form.
Masking: Single (Investigator)
Primary purpose: Health Services Research
Keywords: Gynecological laparoscopy; standard CO2; heated-humidified CO2; hemodynamic parameters; respiratory parameters