bioihbjkbjnl/mcl2 huggingface dataset:
Validity Reliability of The Dubousset Functional Test in Parkinson Disease
Condition: Parkinson Disease; Balance; Distorted; Fall; Gait Disorders, Neurologic
MeSH terms: Parkinson Disease; Nervous System Diseases; Gait Disorders, Neurologic
Study type: Interventional

Summary: 
      In order to achieve collaborative patient-centered rehabilitation in Parkinson's disease,
      detailed evaluation of walking and balance in evaluating the perceived difficulty in daily
      life is important to evaluate the progression of the disease and its response to treatments.

      In the literature, there are many scales that evaluate balance and functional performance in
      Parkinson Disease. However there is no validity and reliability study of Dubousset Function
      Test developed to evaluate balance and functional performance of Parkinson Disease. For this
      reason, the aim of study is to examine the validity and reliability of Dubousset Function
      Test in Parkinson Disease.
    

Detailed description: 
      Balance disorders are very common in patients with Parkinson's, and these disorders
      significantly affect the patient's body alignment and participation. Especially during
      walking, balance disorders occur, resulting in falls, disability and injury in the advanced
      stage of the disease. As a result of these losses in patients, falls can be seen, and the
      severity of disability that increases with age affects the quality of life of individuals by
      affecting their living in their own homes.

      Dubousset Functional Test (DFT); A conceptually practical four-component assessment test has
      been proposed by Dr. Jean Dubousset to assess the functional capacity of adult individuals.
      The validity of the test was made in individuals with spinal deformity. DFT; It consists of
      four components: getting up from a chair without arms and walking 5 meters forward and
      backward, descending and climbing steps, transition from standing to sitting on the ground,
      and the dual task test in which the individual walks while counting down from 50 at the same
      time

      In the literature, there are many scales that evaluate balance and functional performance in
      Parkinson Disease. However there is no validity and reliability study of Dubousset Function
      Test developed to evaluate balance and functional performance of Parkinson Disease. For this
      reason, the aim of study is to examine the validity and reliability of Dubousset Function
      Test in Parkinson Disease.
    

Intervention name(s): dubousset functional test
Intervention type(s): Other
Intervention description(s): Dubousset Function Test, 3-m backwards walk test, timed up and go test,Tinnetti Balance and Gait Test, Berg BalanceTest, Functional Reach Test
Intervention model: Sequential Assignment
Masking: None (Open Label)
Primary purpose: Other
The Study About the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure
Condition: Helicobacter Pylori Infection
Study type: Observational

Summary: 
      The patients who accepted the quadruple eradication program of the helicobacter pylori but
      failed to eradicate helicobacter pylori will be assessed the most suitable re-eradication
      time of helicobacter pylori.
    

Detailed description: 
      Helicobacter pylori (HP) infection is a common global infectious disease, which is an
      important cause of chronic gastritis, peptic ulcer and gastric cancer. At present, due to the
      non-standard Helicobacter pylori eradication program in clinical work, poor patient
      compliance and other reasons, the phenomenon of HP eradication treatment failure is more and
      more common. However, there is still no conclusion on the most appropriate time for remedial
      treatment inpatients with Hp eradication failure.
    

Intervention name(s): Amoxicillin,Furazolidone; Amoxicillin,Levofloxacin; Tetracycline,Furazolidone
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Amoxicillin-Furazolidone-containing quadruple group; Amoxicillin-Levofloxacin-containing quadruple group; Tetracycline-Furazolidone-containing quadruple group
Intervention MeSH terms: Amoxicillin; Levofloxacin; Tetracycline; Furazolidone
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        The patients in Shandong province,aged between 18 and 70 years old, with positive H. pylori
        infection that was eradicated by previous therapies but failed are included.
      
Keywords: Helicobacter pylori; Re-eradication time; Remedial treatment
Providing Online Counseling for Home-Based HIV Testing With Transgender Youth
Condition: Hiv; Transgender Youth
Study type: Interventional

Summary: 
      This research study will recruit 200 transgender youths between the ages of 15-24. There are
      two arms to the research study: the control and the intervention arm. Each eligible
      participant will be randomized into either arm. The control arm participants receive an
      OraQuick HIV testing kit sent to an address of their choice and instructions of how to
      conduct the test. They will enter their results on the research study website and complete
      surveys at 3 month intervals until an entire year has passed. Participants in the
      intervention arm will receive an OraQuick HIV testing kit sent to them and will receive
      video-based counseling called Motivational Interviewing and Certified Testing and Referral.
      After this counseling session, the results from the OraQuick HIV test will be logged by study
      staff. Then, participants in the intervention arm will fill out surveys at 3 month intervals
      until a year has passed.
    


Intervention name(s): at-home test kit; Motivational Interviewing and Certified Testing and Referral
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Transgender youth in the control arm will receive test kits, but will not receive any testing intervention. Once individual results are reported, participants will be contacted via phone or email by study staff with options for referrals to services. Participants will complete follow-up surveys at 3, 6, 9, and 12 months post-testing.; Transgender individuals randomized to the experimental group (MI/CTR) will receive HIV counseling and testing via an online, HIPPA-compliant videoconferencing service. The session will last less than one hour and focus on HIV testing, prevention strategies, and/or linkage to HIV care, depending on the individual's test results. Participants will complete follow up surveys at 3, 6, 9 and 12 months.
Other intervention name(s): MICTR MI/CTR
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: HIV; transgender; trans; youth; home testing
Bioequivalence Study to Compare Fluticasone Furoate (FF) 1-strip Inhaler With FF 2-strip Inhaler and With FF/Vilanterol Combination
Condition: Asthma
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine the bioequivalence of fluticasone furoate (FF)
      inhalation powder (single strip configuration) compared with FF inhalation powder (two strip
      configuration) and compared with FF / vilanterol (VI) inhalation powder. Fluticasone furoate
      (FF), is being developed both as a monotherapy for the treatment of asthma and in combination
      with vilanterol (VI) for the treatment of asthma and Chronic Obstructive Pulmonary Disease
      (COPD). Thirty healthy male and female subjects will be enrolled in the study to ensure
      twenty-four evaluable subjects.
    

Detailed description: 
      Fluticasone furoate (FF; GW685698), a novel corticosteroid, is being developed both as a
      monotherapy for the treatment of asthma and in combination with vilanterol (VI; GW642444) for
      the treatment of asthma and COPD. The novel dry powder inhaler (NDPI) will be used to deliver
      both FF monotherapy and the FF/VI combination. The NDPI can be used with either a single
      strip or two strips, the single strip being used for FF monotherapy and two strips being used
      to deliver the FF/VI combination. In some previous FF monotherapy studies, including the
      phase IIB programme, conducted using the NDPI, the inhaler contained two strips (FF in the
      first strip and matched VI placebo in the second strip). This two strip configuration has
      been used for the majority of FF monotherapy treatment arms in previous and ongoing studies.
      The aim of this study is to determine the bioequivalence of FF monotherapy (single strip)
      compared with FF monotherapy (two strip), and to determine the bioequivalence of FF
      monotherapy (single strip) compared with FF/VI, administered via the NDPI. This data will
      facilitate the inclusion of FF monotherapy (two strip) data and FF/VI combination data to
      support the FF monotherapy product development. This will be a randomised, open-label,
      replicate, six-way crossover, single dose study in healthy male and female subjects. Thirty
      healthy male and female subjects will be enrolled in this study to ensure twenty-four
      evaluable subjects.

      Pharmacokinetic samples will be taken over 36 hours. Safety will be assessed by adverse event
      (AE) monitoring throughout the study.
    

Intervention name(s): Fluticasone Furoate (200mcg unit strength); Fluticasone Furoate/Vilanterol (200/25mcg unit strength)
Intervention type(s): Drug; Drug
Intervention description(s): inhalation powder; inhalation powder
Intervention MeSH terms: Fluticasone; Xhance
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: bioequivalence; pharmacokinetics; Fluticasone Furoate; Vilanterol
Pharmacokinetics of Gepotidacin Tablets in Adults and Adolescents Subjects
Condition: Infections, Bacterial
MeSH terms: Bacterial Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      This is double-blind, randomized, sequential, two part study. Part 1 is a 3 periods,
      fixed-sequence study and will be conducted to evaluate the pharmacokinetics, safety, and
      tolerability of the gepotidacin tablet in healthy adult subjects. Part 2 is a 2 periods,
      fixed-sequence study and will evaluate the pharmacokinetics, safety, and tolerability of the
      gepotidacin tablet in healthy adolescent subjects. The primary purpose of Part 1 is to
      evaluate the pharmacokinetics of a single 1500 milligram (mg) dose and two 3000 mg doses of
      gepotidacin given 6 and 12 hours apart in adult subjects; Part 2 is to evaluate the
      pharmacokinetics of a single 1500 mg dose and two 3000 mg doses of gepotidacin given at a
      dosing interval (to be determined based on the pharmacokinetic and safety results from Part
      1) in adolescent subjects. The duration of Part A will be approximately 47 days and 52 days
      for Part 2.
    


Intervention name(s): Gepotidacin; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Tablets containing gepotidacin mesylate with a unit dose of 750 mg will be administered orally with 240 milliliter (mL) of water.; Tablets containing unit dose of placebo matching of gepotidacin will be administered orally with 240 mL of water.
Intervention MeSH terms: Gepotidacin
Allocation: Randomized
Intervention model: Sequential Assignment
Intervention model description: Part 1 is a 3-period, fixed-sequence study of a single 1500-mg dose (Period 1) and two 3000-mg doses of gepotidacin at Hours 0 and 12 (Period 2) and Hours 0 and 6 (Period 3) in healthy adult subjects. Part 2 is a 2-period, fixed sequence study of a single 1500 mg dose (Period 1) of gepotidacin and two 3000 mg doses (Period 2) of gepotidacin in healthy adolescent subjects. .
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: GSK2140944; Gepotidacin; Pharmacokinetics; Healthy Adult; Healthy adolescent
Cognitive Rehabilitation in Parkinson's Disease
Condition: Parkinson's Disease
MeSH terms: Parkinson Disease
Study type: Interventional
Phase: Early Phase 1

Summary: 
      We are testing a computer game-style rehabilitation program for people with Parkinson's
      disease (PD). People with PD often have difficulty with motor planning, such as initiating or
      starting movements. We believe that our program will improve performance on a movement
      initiation task as well as on activities of daily living, such as walking, preparing a meal
      or opening a medicine bottle. We will measure brain function using functional MRI before and
      after training to identify brain areas that are involved in improved performance. If
      effective, computer based training will be an inexpensive treatment for motor planning
      deficits in PD that is free from side effects and easy to administer to a large number of
      patients.
    

Detailed description: 
      Our approach is to use PD-based adaptive training to improve performance on IG movement
      initiation in patients with PD. We have three aims, 1) to systematically evaluate cognitive
      rehabilitation in people with Parkinson's disease (PD), 2) to examine the neural mechanisms
      subserving cognitive rehabilitation in PD and 3) to assess the ecological validity of
      cognitive rehabilitation in PD. We will focus on a single aspect of cognitive function, the
      decision to initiate a movement. Movements can be internally generated (IG) or externally
      cued, and motor deficits in PD are typically linked to IG movements. The protocol is designed
      to drive beneficial neuroplastic changes using a paradigm similar to those that have shown
      promising results in traumatic brain injury patients. In addition, we will use fMRI to
      measure activity in underlying basal ganglia-thalamocortical circuits. Finally, because the
      goal of any research regarding the pathophysiology of disease is to improve the lives of
      patients with the disease, behavioral and neuropsychological measures will be correlated with
      fMRI measured functional abnormalities before and after training. Improvement in the
      initiation of movement has the potential to dramatically improve daily functioning including
      reducing falls, improving language production and improving proficiency of activities of
      daily living.
    

Intervention name(s): PC based training
Intervention type(s): Behavioral
Intervention description(s): Subjects sit at a computer and type a string of numbers that appears on the screen. As performance improves (# correct), the strings of numbers get longer. They are then instructed to repeat the string from memory. Performing these key entries from memory is a test of internally generated movement initiation.
Other intervention name(s): training
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Parkinson's disease; Cognitive deficits; fMRI; neuro rehabilitation; Age Matched Controls
Double-blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression
Condition: Bipolar Disorder
MeSH terms: Bipolar Disorder
Study type: Interventional
Phase: Phase 3

Summary: 
      Double-Blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression
      Previously Diagnosed and Treated as Recurrent Major Depression: This study recruits males and
      females aged 18 - 70 who currently meet diagnostic criteria for bipolar I or bipolar II
      disorder and are currently experiencing an episode of major depression. Patients are
      randomized to double-blind treatment with divalproex sodium ER or placebo and remain in the
      study for up to six weeks. This six-week double-blind treatment period is followed by an
      open-label treatment period of six months duration. This study is sponsored by Abbott
      Laboratories.
    


Intervention name(s): Divalproex Sodium ER; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Tablets will be available in 250mg and 500mg strengths. Divalproex will be titrated to a minimum blood level of 50 mg/L. However, the investigators will titrate divalproex to the maximum tolerable dose with an expected average dose of 2000mg per day. By dosing in this manner, all subjects will have a minimum blood level of 50 mg/L, but the mean level is likely to be considerably higher.; . Tablets will be available in 250mg and 500mg strengths. Divalproex will be titrated to a minimum blood level of 50 mg/L. However, the investigators will titrate divalproex to the maximum tolerable dose with an expected average dose of 2000mg per day. By dosing in this manner, all subjects will have a minimum blood level of 50 mg/L, but the mean level is likely to be considerably higher.
Other intervention name(s): Depakote ER
Intervention MeSH terms: Valproic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Protein Eating Patterns and Weight Loss
Condition: Obesity
MeSH terms: Weight Loss
Study type: Interventional

Summary: 
      The purpose of this study is to determine the effects of daily protein intake patterns on
      body composition and eating behaviors during weight loss.
    

Detailed description: 
      The reinforcing value of food varies greatly among individuals, but is strongest for those
      who are overweight or obese. Reducing energy intake, which is necessary for overweight and
      obese individuals to achieve a healthier body weight, increases the reinforcing value of food
      - especially for energy-dense snack foods. Food is a powerful reinforcer and is associated
      with energy intake; making it a primary contributing factor to an individual's weight loss
      struggle. Developing a way to decrease or limit the increase in food reinforcement during
      energy deficits would have important clinical impact. High-protein diets are known to be
      efficacious for weight loss and recently have been shown to decrease stimulation of the
      reward areas of the brain that stimulate reward-driven eating behavior. Nonetheless,
      sustaining a high-protein diet can be difficult, especially for women. Consuming a modest
      amount of protein at each meal may be better tolerated. However, we do not know whether this
      pattern of protein intake can assist women in staying "on track" with weight loss goals. This
      study will help begin to elucidate the connections between the daily pattern of protein
      intake on diet adherence, alterations in food reinforcement, and favorable body composition
      changes during weight loss.
    

Intervention name(s): Even protein; Skewed protein
Intervention type(s): Other; Other
Intervention description(s): Intake of even protein 5 day rotating menu; Intake of skewed protein 5 day rotating menu
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Protein; Weight Loss
Development of Exercise Protocol for Scoliosis Using Surface Electromyography(S-EMG)
Condition: Idiopathic Scoliosis
MeSH terms: Scoliosis
Study type: Interventional

Summary: 
      There has been much effort in recent years to better understand the causes of idiopathic
      scoliosis (IS). Some studies suggested muscle imbalance as a cause of scoliosis based on
      asymmetric muscular activation. Surface electromyography can evaluate asymmetrical muscular
      weakness. Therefore, the peak amplitude values can be used to compare the side to side
      differences in paraspinal muscles. From these findings the investigators improve the exercise
      method of IS according to muscle weakness and curve pattern.
    

Detailed description: 
      Design: Prospective study Setting: hospital rehabilitation department the investigators will
      check the muscular activation at bilateral paraspinal muscles with surface electromyography
      and curve type with simple radiography.

      Intervention: After that the investigators educate asymmetrical stabilization exercise
      according to muscle weakness and curve pattern.

      Main outcome measures: Cobb angle
    

Intervention name(s): asymmetrical stabilization exercise
Intervention type(s): Behavioral
Intervention description(s): Exercise is combined to form an appropriate combination of motion (Side-lying, Bird-dog, Prone arm lift, Prone leg lift) according to the curve pattern and muscle weakness of each patient's.
Intervention model: Single Group Assignment
Intervention model description: Annual evaluation after educating asymmetrical stabilization exercise. Cohort study.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: surface EMG, cobb angle, exercise, Spinal Curvatures
Fatigue Self-Management in Primary Care
Condition: Medically Unexplained Chronic Fatigue; Chronic Fatigue Syndrome
MeSH terms: Fatigue Syndrome, Chronic; Fatigue
Study type: Interventional

Summary: 
      This study will evaluate, in a primary care setting, the effectiveness of a brief
      self-management behavioral treatment in patients with medically unexplained chronic fatigue.
      The hypothesis will be tested that fatigue self-management will yield improvements in
      fatigue,functioning, and distress in comparison to the two control conditions: standard
      medical care alone or standard medical care plus an attention control symptom monitoring
      condition.
    


Intervention name(s): Cognitive-behavioral self-management; Symptom monitoring
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Graded activity, pacing, stress reduction, low effort pleasant activities, cognitive coping skills.; Daily symptom via web diary
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Medically unexplained chronic fatigue; Chronic fatigue syndrome; Cognitive-behavior therapy; Self-management; Primary care; Nurses; Economic analysis; Cost effectiveness; One year follow-up