bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Square-stepping Exercise Training on the Attention, Dynamic Balance and Lower Extremity Motor Coordination
Condition: Sedentary Healthy Young Individuals
Study type: Interventional

Summary: 
      Physical activity plays an indispensable role to lead a healthy life. Square-stepping
      exercises (SSE) are aerobic exercises. Our study was designed to investigate the effects of
      square-stepping exercise training on the attention, dynamic balance and lower extremity motor
      coordination of sedentary healthy young individuals.

      A total of 112 volunteers within the age range of 20-25 participated in the research.
      Participants were randomly divided into two groups, as 56 participants were study group (28
      females, 28 males) and 56 participants were control group (28 females, 28 males). Demographic
      data and exercise habit of the individuals were documented. Stroop Test was used to assess
      Attention, Four-step Square Test was used to assess Dynamic Balance and Lower-extremity Motor
      Coordination Test was used to assess Motor Coordination. Throughout 3 weeks SSE training was
      administered 4 days a week for a length of 45 minutes in each session. All the analyses were
      conducted at the start and at the end of 3-week long training.
    


Intervention name(s): Exercise Trainig
Intervention type(s): Other
Intervention description(s): SSE is performed on a thin exercise mat divided into 40 small squares in 250 cm x 100 cm of size (25 cm each part). Participants are given patterns of a few steps and asked to take steps that match them. Participants must, in principal, move ahead in line with the length forward with no contact on the lines forming the squares. Forward, backward, lateral and oblique stepping patterns are required. Stepping patterns get increasingly difficult. Each pattern consists of 2 to 16 steps; participants are asked to repeat step pattern till the end of exercise mat. Upon completing a pattern, another pattern in the same mirror-image is repeated. In essence each pattern is reiterated for 3-5 times and next its mirror-image pattern is repeated but if participants face challenge in performing the pattern it is repeated till the pattern is learnt
Other intervention name(s): Square-steeping exercise
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Square-stepping exercise training; attention; dynamic balance; motor coordination
Open Treatment of Minocycline in Geriatric Depression
Condition: Depression
MeSH terms: Depression; Depressive Disorder
Study type: Interventional

Summary: 
      This research study will examine whether elderly depressed patients whose depressive symptoms
      do not respond satisfactorily to therapy with a mood stabilizer or antidepressant alone gain
      any benefit from taking minocycline alone or in addition to their antidepressant or mood
      stabilizer medication. Minocycline is a commonly used antibiotic medication with
      anti-inflammatory properties. It is hoped that information gained from this study will help
      the investigators better understand the role of inflammation in depression, and whether
      decreasing inflammation will lead to improvement in the symptoms of depression and cognitive
      function.
    

Detailed description: 
      This research study will examine whether elderly depressed patients whose depressive symptoms
      do not respond satisfactorily to antidepressant therapy alone gain any benefit from taking
      minocycline alone or in addition to their antidepressants. Minocycline is a commonly used
      antibiotic medication with anti-inflammatory properties. It is hoped that information gained
      from this study will help the investigators better understand the role of inflammation in
      depression, and whether decreasing inflammation will lead to improvement in the symptoms of
      depression and cognitive function. Elderly patients with depression who remain symptomatic
      after at least 6 weeks of treatment with an antidepressant medication reaching a therapeutic
      dosage will be recruited and receive minocycline augmentation for 8 weeks. They may or may
      not remain on their antidepressants based on their physicians' clinical recommendation.
      Response to treatment will be measured weekly during the first four weeks and every other
      week thereafter using rating scales of depressive symptoms, intellectual functions and side
      effects.
    

Intervention name(s): Minocycline
Intervention type(s): Drug
Intervention description(s): Minocycline 100 mg twice daily for 8 weeks
Intervention MeSH terms: Minocycline
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Evaluation of 3 Oral Self-care Regimens on Clinical Signs of Inflammation and Plaque
Condition: Gingivitis
MeSH terms: Gingivitis; Inflammation
Study type: Interventional

Summary: 
      To compare three different oral hygiene regimens on changes in gum tissue appearance, gum
      bleeding, and plaque scores.
    

Detailed description: 
      The goal of this clinical trial was to compare the effect of different battery powered water
      in and adult population with mild to moderate gingivitis. The main questions it aims to
      answer are:

        -  Is there a difference between the two water flosser devices on gum bleeding scores?

        -  Is there a difference between the two water flosser devices on plaque accumulation and
           removal?

        -  Is there a difference between the two water flosser devices on signs of gingivitis?

      Researchers will compare the two groups using a water flosser (experimental) to see how it
      compares to traditional brushing and flossing (control).
    

Intervention name(s): Waterpik Water Flosser; Oral-B Water Flosser; Waxed Dental Floss
Intervention type(s): Device; Device; Device
Intervention description(s): A pulsating water flosser and jet tip designed to clean between the teeth and below the gingival margin.; A water flosser and specialized tip that delivers water with microbubbles of air; Nylon string used to clean between the teeth manually
Other intervention name(s): dental water jet; oral irrigator; dental water jet; oral irrigator
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Prevention
An Imaging Study to Investigate the Distribution of GSK239512 in the Brain.
Condition: Mild Cognitive Impairment; Dementia
MeSH terms: Cognitive Dysfunction
Study type: Interventional
Phase: Phase 1

Summary: 
      GSK239512 is being developed for the treatment of symptoms of cognitive impairment in many
      diseases. GSK239512 is a drug that binds to the Histamine 3 receptor (a protein) in the brain
      (receptor occupancy). This study will use the technique of positron emission tomography (PET)
      as an imaging tool to highlight areas of the brain that GSK239512 has penetrated, and
      subsequently bound to receptors, after receiving an oral dose of the drug. It will also look
      at the rate the drug dissociates from the receptors in the brain. Results from the study will
      provide information on doses of the drug to be given in further studies.
    


Intervention name(s): GSK239512
Intervention type(s): Drug
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: AD, H3, Brain, Cognitive Impairment
Safety and Ocular Pharmacokinetics After 1 Drop of T1225 0.5, 1 and 1.5% in 48 Healthy Volunteers
Condition: Eye Infections, Bacterial
MeSH terms: Bacterial Infections; Eye Infections; Eye Infections, Bacterial
Study type: Interventional
Phase: Phase 1

Summary: 
      To compare the ocular tolerance, safety and ocular pharmacokinetics of 3 concentrations (0.5%
      - 1.0% - 1.5%) and the vehicle of T1225.
    

Detailed description: 
      The present phase I clinical trial was performed in order to investigate the ocular
      tolerance, safety and the ocular pharmacokinetics of a single administration of T1225 eye
      drops (0.5%, 1.0%, or 1.5%) in healthy volunteers.
    

Intervention name(s): Azithromycin (T1225)
Intervention type(s): Drug
Intervention MeSH terms: Azithromycin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Mobile Intervention to Improve Functional Health and Community Engagement of Post-9/11 Veterans With Chronic Insomnia
Condition: Chronic Insomnia
MeSH terms: Sleep Initiation and Maintenance Disorders
Study type: Interventional

Summary: 
      Veterans of the most recent wars in Afghanistan and Iraq (collectively, post 9/11 Veterans)
      have notable sleep problems including chronic insomnia. Here, the investigators plan to
      compare two groups of veterans with insomnia: (1) one group that completes a 6 week
      self-management-guided use of a mobile app based on cognitive behavioral therapy for insomnia
      (CBTI alone) and (2) one group that completes a 6 week combined self-management-guided use of
      the mobile CBTI app in addition to a physical activity (PA) intervention (CBTI + PA). The
      investigators hypothesize that the group receiving the adjunctive 6-week PA intervention will
      have better subjective and objective sleep, higher step counts, and better functional health
      and social and community integration than those receiving CBTI alone. This pilot work will
      provide evidence to guide the design of a future randomized controlled trial.
    

Detailed description: 
      To determine if the addition of physical activity (PA) to (CBTI) can further enhance sleep,
      physical activity, functioning, or social engagement over and above self-management use of a
      CBTI app alone, the investigators will randomly assign post-9/11 veteran participants with
      chronic, functionally impairing insomnia to either (1) a self-management-based use of an app
      based on cognitive behavioral therapy for insomnia (CBTI; CBTI alone arm) or to (2) a
      self-management-based use of the CBTI app + a physical activity (PA) intervention (CBTI + PA)
      that includes PA monitoring (via a Fitbit device) with individualized goal-setting to
      encourage increased daily steps across the 6 weeks. For the PA goal, the investigators will
      attempt to get all participants to at least the typical 10,000 daily steps goal cited as a
      strong predictor of positive health outcomes (Choi, Pak, & Choi, 2007). The investigators
      will tailor the step goals based on the person's initial level of daily steps, and increment
      step goals weekly to maximize motivation and enhance the likelihood that the participant can
      meet the goal.
    

Intervention name(s): CBTI app intervention; Physical Activity intervention
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Self-management guided use of a mobile app called the CBT-I Coach to teach sleep hygiene and enhance sleep; Self-management guided motivation to increase physical activity by increasing daily step counts
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: mobile health; physical activity
Evaluation Of A Novel Methodology In The Assessment Of Urethral Function Using SS-RBX.
Condition: Urinary Incontinence, Stress
MeSH terms: Urinary Incontinence; Enuresis; Urinary Incontinence, Stress
Study type: Interventional
Phase: Phase 2

Summary: 
      SS-RBX will be used to evaluate pharmacodynamic changes in urethral function using a novel
      methodology
    


Intervention name(s): SS-RBX
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double
Primary purpose: Treatment
Complications After Thyroid Surgeries: 10 Years' Experience
Condition: Thyroid
MeSH terms: Thyroid Diseases
Study type: Observational

Summary: 
      Thyroidectomy is one of the commonest elective surgeries in surgical practice nowadays. It is
      associated with wide range of complications, from unnoticed events up to lifelong problems
      and even life-threatening complications. The most troublesome are bleeding, nerve injury and
      hypocalcemia. The current study was conducted to report the incidence and predictive factors
      for perioperative complications, aiming to point out preventive measures.
    

Detailed description: 
      All files of all patients that had thyroidectomy in the hospital in the last 10 yeas will be
      reviewed. All demographic and peri-operative data will be collected, tabulated and analyzed.

      Incidence and pre-operative predictive factors of every single complication will pointed out
      and discussed.
    

Intervention name(s): Thyroidectomy
Intervention type(s): Procedure
Intervention description(s): Thyroidectomy
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        All patients had thyroid diseases and had thyroidectomy in our hospital in last 10 years.
      
Keywords: Thyroidectomy; Hypocalcemia; Stridor; Bleeding; Recurrent Laryngeal Nerve
COREG MR Versus TOPROL-XL On The Lipid Profile Of Normolipidemic Or Mildly Dyslipidemic Patients With Hypertension
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional
Phase: Phase 3

Summary: 
      This study was designed to determine whether treatment with COREG MR is more effective at
      maintaining a better lipid profile than treatment with TOPROL-XL for hypertension.
    


Intervention name(s): Carvedilol Phosphate modified release formulation; metoprolol succinate
Intervention type(s): Drug; Drug
Other intervention name(s): Carvedilol Phosphate modified release formulation
Intervention MeSH terms: Metoprolol; Carvedilol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: hypertension
Study to Assess Antioxidant Efficacy of Spirulina on oxLDL and Lipids Metabolism on Subjects With Metabolic Syndrome
Condition: Metabolic Syndrome
MeSH terms: Metabolic Syndrome; Syndrome
Study type: Interventional

Summary: 
      The purpose of this pilot study is to assess the beneficial effect of a spirulina water
      extract (product named Spirulysat®) compared to a placebo in the blood level ratio of
      oxidized LDL / total LDL cholesterol in subjects with metabolic syndrome after 12 weeks of
      consumption
    


Intervention name(s): Spirulysat®; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Bortezomib to Treat Significant Complication of HSCT
Condition: Allogeneic Stem Cell Transplantation; Refractory Autoimmune Cytopenia(s)
MeSH terms: Anemia; Leukopenia; Thrombocytopenia
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this trial is to study the safety and effectiveness of a drug called
      Bortezomib for the treatment of low blood cell counts after bone marrow transplant.
    

Detailed description: 
      The purpose of this research study is to study the safety and effectiveness of a drug called
      bortezomib for the treatment of autoimmune cytopenia(s) (low blood cell counts) after bone
      marrow transplant that are not responding to standard treatments. Autoimmune cytopenias are
      low blood counts due to antibodies or proteins produced against an individual's own blood
      cells. Having a low red blood cell count (anemia) can make a person feel tired and require
      blood transfusions frequently. A low platelet count (blood cells that help blood to clot) can
      make a person bleed or bruise easily. A low neutrophil (white blood cell) count can make a
      person have infections.

      All of these things can be a serious complication after bone marrow transplant and can cause
      prolonged hospital stay. Bortezomib is being used in children with certain types of blood
      cancer, however, bortezomib has not been used in children with autoimmune cytopenia(s) and
      its use in this study is investigational.
    

Intervention name(s): Bortezomib
Intervention type(s): Drug
Other intervention name(s): PS-341; Velcade
Intervention MeSH terms: Bortezomib
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: HSCT; cytopenia; immune suppression; proteasome inhibitor
Evaluate the Efficacy and Safety of Saxagliptin in Combination With Metformin IR Compared to Saxagliptin Monotherapy and to Metformin IR Monotherapy in Drug Naive Chinese Subjects With Type 2 Diabetes Who Have Inadequate Glycaemic Control
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 3

Summary: 
      A Multicenter, Randomized, Double-Blind, Active-Controlled, Phase 3 Trial to Evaluate the
      Efficacy and Safety of Saxagliptin in Combination with Metformin IR as Initial Therapy
      Compared to Saxagliptin Monotherapy and to Metformin IR Monotherapy in Subjects with Type 2
      Diabetes who have Inadequate Glycaemic Control
    

Detailed description: 
      Allocation: Randomized Endpoint Classification: Efficacy/Safety study Intervention Model:
      Parallel Assignment Masking: Double Blind Primary Purpose: Treatment
    

Intervention name(s): Saxagliptin 5 mg; Placebo 5 mg for Saxagliptin; Placebo 500 mg for metformin (with titration); Metformin 500 mg with titration
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Tablet, Oral, 5 mg, Once daily in the morning; Tablet, Oral, 5 mg, Once daily in the morning; Tablet, 500 mg, Once daily in the evening the first two weeks and thereafter according to titration.; Tablet, 500 mg, Once daily in the evening the first two weeks and thereafter according to titration.
Other intervention name(s): Onglyza; BMS-477118; Glucophage
Intervention MeSH terms: Metformin; Saxagliptin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Type 2 Diabetes Mellitus, Dipeptidyl-Peptidase 4 Inhibitors, Saxagliptin, Metformin, Endocrine System Diseases
Methylprednisolone for Children With Severe Mycoplasma Pneumoniae Pneumonia (MCMP)
Condition: Mycoplasma Pneumoniae Pneumonia
MeSH terms: Pneumonia; Pleuropneumonia; Mycoplasma Infections; Pneumonia, Mycoplasma
Study type: Interventional

Summary: 
      The study is designed to investigate difference in percentage of presentation of atelectasis,
      bronchiectasis, bronchiolitis obliterans, or consolidation in 6 months after discharge in
      those treated with a low dose regimen of methylprednisolone initiated with 2 or 4 mg/kg/d for
      3 days followed by tapering, combined with sequential treatment with azithromycin versus a
      high dose regimen of methylprednisolone initiated with 10 mg/kg/d for 3 days followed by
      tapering, combined with sequential treatment with azithromycin.
    

Detailed description: 
      Mycoplasma pneumonia pneumonia (MPP) accounts for approximately 10-30% of childhood
      community-acquired pneumonia (CAP) in China. Macrolide is the first choice for MPP. However,
      progression to severe pneumonia might occur despite antibiotics therapy. And some patients
      have sequelae of bronchiolitis obliterans, bronchiectasis and atelectasis, et al. Based on
      inflammatory and immunological mechanism, there is some clinical evidence that adjuvant of
      corticosteroid reduced morbidity and improved the outcome in the children with severe MPP.
      However, the dosage of corticosteroid varied greatly in studies. Therefore, a large
      prospective study is needed to define the benefits of high-dose corticosteroid therapy in
      MPP.

      Patients will be randomized into two groups: the low dose group and the high dose group. The
      low dose group will receive methylprednisolone 2 or 4 mg/kg/d for 3 days followed by tapering
      in 9 days, combined with sequential treatment with azithromycin. The high dose group will
      receive methylprednisolone 10 mg/kg/d for 3 days followed by tapering in 9 days, combined
      with sequential treatment with azithromycin. After discharge, patients of both groups will be
      followed up at 1, 3, and 6 months.

      The number of pulmonary lesions, including atelectasis, bronchiectasis, bronchiolitis
      obliterans, or consolidations, in 6 months after discharge will be compared in two groups.
      The number of adverse events, such as hyperglycemia, hypertension, increased intraocular
      pressure, will be compared between the two groups.

      The trial will be completed in 36 months, with 424 subjects recruited from 5 hospitals in
      partnership with clinical research collaboration of National Clinical Research Center for
      Respiratory Diseases.
    

Intervention name(s): methylprednisolone
Intervention type(s): Drug
Intervention MeSH terms: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Severe mycoplasma pneumoniae; pneumonia; children