bioihbjkbjnl/mcl2 huggingface dataset:
Comparison of Pilates and Traditional Plank in Recreational Badminton Players.
Condition: Sports Physical Therapy
Study type: Interventional

Summary: 
      To compare the effects of Pilates exercise and traditional plank exercise training on core
      muscle strength, balance and agility in recreational badminton players
    

Detailed description: 
      In modern era, badminton is one of the most famous and played sports worldwide. As compared
      to other indoor games, badminton is considered to be the finest sports as it occupies a place
      of pride for both as an individual and team sport. It is a technical and complex sport
      activity that need massive core strength and whole body strength in strokes, powerful
      smashes, alertness, well balance and coordination during postural movement in the premises of
      the court. Notable, to be competitive in badminton, players need to be able to move quickly
      toward well balanced position that permits them to tackle quickly to hit the shuttlecock.

      The purpose of this study is to compare the effects of pilates exercises and traditional
      plank exercise training on core muscle strength, balance and agility in recreational
      badminton players.
    

Intervention name(s): Pilates exercise program group; Traditional plank exercise program group
Intervention type(s): Other; Other
Intervention description(s): Pilates exercise program group will do a warm-up for 10 minutes and then perform five exercises includes standing footwork, hundreds with knee straight, articulating bridge, rolling like a ball, plank for 25 minutes. For first three weeks, each player will do 8 repetitions × 3 sets of exercises and for next three weeks, each player will do 15 repetitions × 3 sets of exercises. There will be cool-down for 10 minutes after exercises. Total program will be of 45 minutes.; Traditional plank exercise program group will do a warm-up for 10 minutes and then perform five exercises includes prone bridge, side bridge, supine bridge on exercise ball, prone bridge on exercise ball, superman on exercise ball. For first three weeks, each player will do 8 repetitions × 3 sets of exercises and for next three weeks, each player will do 15 repetitions × 3 sets of exercises. There will be cool-down for 10 minutes after exercises. Total program will be of 45 minutes.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Sports Rehabilitation; Pilates; Planks; Strength; Balance; Agility; Badminton
Anemia of Prematurity and Hemodynamics
Condition: Premature
MeSH terms: Premature Birth
Study type: Observational

Summary: 
      The aim of this work to study the hemodynamic changes accompanying anemia of prematurity in
      neonates with gestational age ≤32 weeks and the effect of its treatment on hemodynamics.
    

Detailed description: 
      This prospective observational study aims to evaluate the hemodynamic changes provoked by
      anemia of prematurity and transfusion of packed red blood cells (RBCs). Nonanemic inpatient
      premature infants (Hematocrit>30%) will be compared with pretransfusional anemic inpatient
      premature infants. Anemic premature infants will be assessed before and 24 hours after the
      transfusion of pRBCs. Cerebral, intestinal and renal blood flow velocities, cardiac output
      parameters will be measured in premature neonates who will fulfill the eligibility criteria
      of the study.This study will be conducted at the neonatal intensive care units in Alexandria
      University Hospitals.
    

Intervention name(s): Echocardiographic and Doppler studies
Intervention type(s): Radiation
Intervention description(s): Echographic and Doppler studies will be performed using machine: model GE Vivid iq premium,WUXI,China and we will measure:
Cardiac output:
Cerebral, intestinal and renal blood flow velocities:
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with any of the following will be excluded at the time of assessment:

          -  Hemolytic disease of the newborn.

          -  Shock.

          -  Sepsis.

          -  Ultrasonographic abnormalities of kidney, heart and cerebral structures.
Effect of SRT2379 on Endotoxin-Induced Inflammation
Condition: Sepsis
Study type: Interventional
Phase: Phase 1

Summary: 
      SRT2379 is a potent small molecule activator of SIRT1 that has been found to inhibit systemic
      inflammation induced by intravenous injection of lipopolysaccharide (LPS) in mice. The
      objective of this study is to test if SRT2379 may be a novel compound for the treatment of
      inflammatory disorders in man.
    


Intervention name(s): SRT2379; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): SRT2379 will be supplied as hard gelatin capsules, with each containing 250mg.; Matching placebo will be supplied as hard gelatin capsules, with each containing an appropriate amount of placebo.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Prevalence of Antibodies to Selected Porcine Viruses in Patients With Cystic Fibrosis Receiving Porcine-derived Pancreatic Enzyme Replacement Therapy
Condition: Cystic Fibrosis
MeSH terms: Cystic Fibrosis; Fibrosis
Study type: Observational

Summary: 
      This is a point prevalence study conducted entirely in the United States (US) to establish
      the prevalence of antibodies to hepatitis E virus (HEV) and other selected porcine viruses in
      cystic fibrosis (CF) patients receiving pancreatic enzyme replacement therapy (PERT) for
      pancreatic insufficiency compared with matched (age and region of residence) control patients
      with chronic medical conditions unexposed to PERT.
    

Detailed description: 
      This is a multicenter, non-interventional point-prevalence study conducted in the US to
      determine the seroprevalence of antibodies to selected porcine viruses in pancreatic enzyme
      replacement therapy-exposed CF patients and in an unexposed control group with chronic
      medical conditions matched for age and geographic region of residence. Data collection
      includes demographic and medical history, pancreatic enzyme replacement therapy, transfusion
      history, and history of potential exposure to pig viruses. If a patient meets all the
      requirements of the study and provides a study specific informed consent/assent, a single
      blood sample is obtained as part of a planned standard-of-care blood collection.

      This harmonized protocol reflects equal sponsorship not only by the registering Sponsor,
      AbbVie, but also the Collaborators, Aptalis Pharma and Janssen Research & Development, LLC.
    

Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Cystic fibrosis (CF) patients receiving pancreatic enzyme replacement therapy (PERT) and
        patients with chronic disease not receiving any PERT.
      
Biospecimen description: 
      Serum specimens for subsequent assay for antibodies to HEV and other selected porcine viruses
    
Keywords: pancreatic enzyme replacement therapy; antibodies; porcine viruses; epidemiology; prospective
Remotely Monitoring Patients With Chronic Conditions in Their Home
Condition: CHF
Study type: Observational

Summary: 
      Study will collect data from the home using the CoVa Monitoring System. Data will be captured
      and retrospectively analysis to determine if the data provided can alert clinician about a
      patient's declining health.
    

Detailed description: 
      Study will collect data from the home using the CoVa Monitoring System. Data will be captured
      and retrospectively analysis to determine if the data provided can alert clinician about a
      patient's declining health. Data from the CoVa Monitoring System will be compared against
      electronic health records to determine if the data captured will provide insight into a
      patient's overall health. Additionally, user compliance will be monitored
    

Intervention name(s): Discontinuation of using device
Intervention type(s): Device
Intervention description(s): Subject will be instructed to discontinuation of use of device
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Patients receiving home health care with one or more chronic diseases including CHF
Evaluation of Biomarkers Levels in Gingival Crevicular Fluid, Saliva and Serum for Different Periodontal Diseases
Condition: Mouth Diseases; Periodontal Inflammation; Periodontal Diseases
MeSH terms: Periodontal Diseases; Mouth Diseases; Inflammation
Study type: Interventional

Summary: 
      The aim of this study is; detection of interleukin(IL)-38, IL-36 gamma(γ) , IL-17 and matrix
      metalloproteinase(MMP)-9 levels in gingival crevicular fluid (GCF), saliva and serum samples
      of periodontally healthy, gingivitis and periodontitis patients and the possible correlation
      between these values and clinical parameters of periodontal diseases. Materials and methods:
      Samples were obtained from 90 systemically healthy non-smoker individuals with periodontitis
      (P, n=30), gingivitis(G, n=30) and healthy periodontium (S, n=30). Full-mouth clinical
      periodontal measurements including probing depth (PD), clinical attachment level (CAL),
      bleeding on probing (BOP), gingival index (GI) and plaque index (PI) were also recorded.
      Enzyme-linked immunosorbent assay (ELISA) was used to determine IL-38, IL-36γ, IL-17 and
      MMP-9 levels in the biological samples.
    


Intervention name(s): GCF obtaining; Saliva Obtaining; Serum obtaining
Intervention type(s): Diagnostic Test; Diagnostic Test; Diagnostic Test
Intervention description(s): GCF obtaining: 2 GCF samples, 1 from the interproximal surface of 2 different teeth that bleeding on probing(-), were taken from each participant; Saliva obtaining: 1,5 ml unstimulated whole saliva collected from each participant; Serum obtaining : 8 ml of venous blood was collected from each participant and collecting blood centrifuged to obtain serum
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: According to full-mouth clinical periodontal measurements including probing depth (PD), clinical attachment level (CAL),bleeding on probing (BOP), gingival index (GI) and plaque index (PI) samples of GCF, saliva and serum were obtained from 90 systemically healthy non-smoker individuals with stage II grade B (P1, n=9), stage III grade B (P2, n=11) , stage III grade C (n=10), gingivitis (G, n=30) and healthy periodontium (S, n=30).
Masking: None (Open Label)
Primary purpose: Diagnostic
Efficacy of a Craniosacral Therapy Protocol in the Treatment of Infant Colic
Condition: Infant Conditions; Colic, Infantile; Gastro-Intestinal Disorder
MeSH terms: Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Colic
Study type: Interventional

Summary: 
      This is a randomised controlled trial that aims to determine the effectiveness of
      craniosacral therapy for the treatment of infantile colic. Manual therapy was applied to a
      group of young infants diagnosed with colic while a second group did not received any
      treatment.
    


Intervention name(s): Manual treatment
Intervention type(s): Other
Intervention description(s): Craniosacral therapy protocol.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Skull; Osteopathic Manipulation; Infantile Colic; Clinical Trial; Massage; Infant; Osteopathic Medicine
Functional Connectivity Changes During Early Recovery as a Marker for Relapse
Condition: Substance Use Disorder
MeSH terms: Recurrence; Substance-Related Disorders
Study type: Observational

Summary: 
      The study purpose is to examine whether there are structural or functional differences in the
      brains of individuals who use cocaine or amphetamines as opposed to control participants who
      have never used cocaine or amphetamines. More specifically, it will allow the investigator to
      see how the brain changes once people get sober and how those changes relate to successful
      recovery. This study will allow the investigator to examine the interaction between
      cocaine/amphetamines and impulsivity (meaning to act on impulse rather than thought). Results
      from this study will inform new biologically-based interventions to compliment existing
      treatment programs, in the hope of leading the field in a new direction.
    


Intervention name(s): MRI: Brain Imaging Data Collection
Intervention type(s): Device
Intervention description(s): This study has no intervention, it is observational. The investigator will collect brain imaging data and behavioral assessments.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Adult individuals with Substance Use Disorder
      
Keywords: fMRI; brain networks; biomarker; relapse; stimulants
To Demonstrate the Relative Bioavailability Study of Loratadine 10 mg Tablets
Condition: Allergy
Study type: Interventional
Phase: Phase 1

Summary: 
      To demonstrate the relative bioavailability study of Loratadine 10 mg tablets.
    


Intervention name(s): Loratadine 10 mg Tablets Under Fasting Conditions (Sandoz, Inc.); Loratadine 10 mg Tablets Under Fed Conditions (Sandoz, Inc.); Claritin (Loratadine) 10 mg Tablets Under Fed Conditions (Schering)
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: Loratadine
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Antihistamine
Vitamin D Supplementation in Healthy Adolescents
Condition: Vitamin D Supplementation
Study type: Interventional

Summary: 
      This double blind, randomized controlled trial compares two supplemental doses of vitamin D
      in health adolescents.
    

Detailed description: 
      Vitamin D deficiency is a common problem. Currently, data do not support a recommended
      vitamin D supplementation dose for health adolescents to maintain normal vitamin D levels.
      This double blind, randomized controlled 12 week trial compares the use of two supplemental
      doses of vitamin D in this population.
    

Intervention name(s): Supplemental Vitamin D
Intervention type(s): Drug
Intervention description(s): Subjects were randomized to either take 200 IU of vitamin D or 1000 IU of vitamin D daily for 11 weeks and labs were compared before and after.
Intervention MeSH terms: Vitamin D
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: vitamin D
A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of 200 Mcg of gp120 (CHO) BIOCINE in MF59 Emulsion Versus the Emulsion Control: Three Injections at 0, 1, and 6 Months
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      To evaluate in healthy volunteers the safety and immune response to 200 mcg gp120 candidate
      vaccine in MF59 emulsion without MTP-PE at 0, 1 and 6 months.

      Preliminary evaluations of two dose levels of gp120 administered to volunteers in protocol
      VEU 007A indicate that a gp120 dose of potentially greater immunogenicity may be of interest.
    

Detailed description: 
      Preliminary evaluations of two dose levels of gp120 administered to volunteers in protocol
      VEU 007A indicate that a gp120 dose of potentially greater immunogenicity may be of interest.

      Ten healthy volunteers receive 200 mcg gp120 in MF59 emulsion, and four volunteers receive
      placebo consisting of MF59 emulsion in PBS vehicle. Injections are given at months 0, 1, and
      6. Patients are followed for 12 months following the third injection.
    

Intervention name(s): rgp120/HIV-1 SF-2
Intervention type(s): Biological
Intervention model: Parallel Assignment
Primary purpose: Prevention
Keywords: Vaccines, Synthetic; HIV Envelope Protein gp120; AIDS Vaccines; HIV Seronegativity; HIV Preventive Vaccine
Cognitive-motor Dual Task Training in Patients With Multiple Sclerosis
Condition: Multiple Sclerosis; Cognitive Impairment; Motor Disorders
MeSH terms: Multiple Sclerosis; Sclerosis; Motor Disorders
Study type: Interventional

Summary: 
      Clinical features of Multiple Sclerosis (MS) vary widely from patient to other. About the 60%
      of patients with MS presents cognitive deficits associated with motor disability. The
      principal consequences of the motor disabilities concern difficult in gait and balance. The
      principal cognitive deficits concern the speed in elaborating information, the complex
      attention and the memory. During walking in daily life, it is often required to turn the head
      for looking something happening in the surrounding environment, for example when a sudden
      noise is heard, while crossing the street, when there's something interesting around or when
      is required to verbally answer to someone without stopping walking. All these examples are
      referred to a common daily life mechanism that has been defined as dual task (DT).
      Considering that the attention is a limited function, divide it in two different and
      simultaneous tasks (motor and cognitive), cause a cognitive-motor interference (CMI) that
      lead to a loss of efficacy in one or in both the tasks. The main aim of the study is to
      verify the impact of a brief rehabilitation training that combining motor and cognitive
      therapy using a dual-task paradigm, on balance and gait in MS patients, compared with the
      traditional therapies that provide a specific postural stability rehabilitation approach.
      Recruited patients will be randomized in two different groups which perform two different
      training. Each group perform the allocated training 3 times a week for 4 weeks. All the
      patients will be evaluated at the baseline (T0), at the end of the training (T1) and 60 days
      after the end of the training (T2).
    


Intervention name(s): Dynamic Postural Stability Training; Cognitive-Motor Training; Conventional Therapy
Intervention type(s): Other; Other; Other
Intervention description(s): The dynamic postural stability training, will consist of marching on unstable surface and on treadmill both with open and with closed eyes.; The cognitive-motor training consisted of a dual task paradigm: each patient was asked to walk without stopping and was explained that, during the task, they might hear a sound, and in that case, they should have look at the stimulus 'side and recognize a visual target. This dual task was performed both marching on an unstable surface and marching on treadmill.; The conventional neuromotor rehabilitation will consist in muscles stretching, active-assisted mobilizations, neuromuscular facilitations, gait training and balance exercises using swinging platforms
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Efficacy and Safety of Inhaled Zanamivir in Treatment of Influenza A and B Virus Infections in China
Condition: Influenza A Virus Infection; Influenza B Virus Infection
MeSH terms: Infections; Communicable Diseases; Virus Diseases; Influenza, Human; Herpesviridae Infections
Study type: Interventional
Phase: Phase 3

Summary: 
      The aim of this study is to evaluate the clinical efficacy and safety of inhaled zanamivir in
      treatment of influenza A and B virus infections in China.
    


Intervention name(s): Zanamivir; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 10 mg inhaled by mouth, twice daily, for 5 days; inhaled by mouth, twice daily, for 5 days
Intervention MeSH terms: Zanamivir
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Motivation-Audit-Positive Psychology Intervention Study
Condition: Metabolic Syndrome
MeSH terms: Metabolic Syndrome; Syndrome
Study type: Observational

Summary: 
      Specific Aim #1: To identify, through qualitative research, deficits in positive emotional
      states (e.g., positive affect, optimism) and associated barriers to completing health
      behaviors, like physical activity and healthy eating, in patients with metabolic syndrome
      (MetS).

      Hypothesis: Participants will be able to complete semi-structured interviews, providing
      information about their positive emotional states, linking the presence of positive emotions
      to better adherence to health-related behaviors, and identifying additional barriers (e.g.,
      logistic, motivational) to completing such behaviors.
    

Detailed description: 
      This qualitative interview study will focus on the development of a novel positive psychology
      (PP) and motivational interviewing (MI) intervention that is adapted for patients with MetS.
      For this phase, participants will be primary care patients recruited through Massachusetts
      General Hospital's research opt-in program (Research Options Direct to You [RODY]). We will
      complete phone interviews with patients (n=20) with MetS within two weeks of enrollment in
      the study.

      In this project, we hope to do the following:

        1. Identify, through qualitative research, deficits in positive emotional states in primary
           care patients with MetS.

        2. Examine potential links between positive emotional deficits and impaired health
           behaviors (low physical activity, unhealthy dietary patterns), as well as links between
           positive emotional states and successful health behaviors.

        3. Identify other barriers to health behavior completion, such as social support and
           neighborhood resources.

        4. Explore strategies to enhance positive emotional states in MetS patients and inquire
           about the utility of potential PP exercises in these patients.

        5. Ask participants for feedback about intervention delivery preferences (e.g., session
           length, time of day, duration of intervention).

        6. Develop a preliminary PP-MI based group intervention using the above information.
    

Observational model: Other
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        Metabolic syndrome patients with a Partners Healthcare provider