bioihbjkbjnl/mcl2 huggingface dataset:
Effectiveness Between Nutritional Counseling Monthly Phone Call Versus Self Help Informative Booklet
Condition: Obesity; Overweight
MeSH terms: Overweight
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the most effectiveness between a personalized
      nutritional program with a counseling monthly phone call Versus personalized nutritional
      program with self help Informative Booklet in a group of obesity or overweight patients
      without counseling phone call.
    

Detailed description: 
      Evaluate the best effectiveness between two methods applied in the Dietary Service of
      institute orthopedic Rizzoli for the achievement of the weight loss. Personalized nutritional
      program with counseling phone call versus personalized nutritional program with self help
      Informative Booklet in a controlled group.There will be compared two groups of patients:
      First group: patients subject to balanced personalized nutritional program associated to
      counseling monthly phone call ; compliance and loss of weight will be done monthly for one
      year. Second group: patients subject to balanced personalized nutritional program associated
      to self help informative Booklet; compliance and loss of weight will be done after six months
      and after one year from the first meeting.
    

Intervention name(s): Counseling Monthly Phone Calls; Self Help Informative Booklet
Intervention type(s): Procedure; Procedure
Intervention description(s): the dietician will call the patient at home, and invite them to answer 11 open questions.The questionnaire collects information about weight loss, behaviors that need to be changed, problem-solving as to how to make the changes and physical activity levels.; Self help informative booklet includes information on how to manage healthy weight, how to lose weight, physical activity and a simplified and abbreviated version of the main behavioural strategies
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: obesity; counselling; weight loss
Exploring the Role of Adipocyte Fatty Acid Binding Protein in the Association of Obstructive Sleep Apnea and Metabolic Dysfunction
Condition: Obstructive Sleep Apnea; Insulin Resistance; Metabolic Syndrome; Inflammation
MeSH terms: Apnea; Sleep Apnea Syndromes; Sleep Apnea, Obstructive; Metabolic Syndrome; Insulin Resistance; Inflammation
Study type: Interventional

Summary: 
      Adipocyte fatty acid binding protein (A-FABP) is a member of the FABP super family, is
      abundant in adipocytes and macrophages. Regulatory functions of A-FABP in lipid and glucose
      metabolism have been described, and it is suggested to play an important role in the
      pathogenesis of metabolic syndrome.We hypothesize that obstructive sleep apnea (OSA) may
      upregulate A-FABP production and thus causally contribute to metabolic dysfunction. Our group
      has recently demonstrated that A-FABP, expressed and secreted from adipocytes, is present in
      the blood stream .The levels of A-FABP correlated with various metabolic variates in the
      metabolic syndrome. Furthermore, we have obtained novel data in men with a range of sleep
      disordered breathing showed that the duration of oxygen desaturation correlated with
      circulating levels of A-FABP, independent of age and waist/body mass index. The current
      proposal aims to pursue this finding and further explore the role of A-FABP in the
      association of OSA and metabolic dysfunction.
    

Detailed description: 
      We hypothesize that there are changes in circulating A-FABP level which can be mitigated by
      effective treatment of OSA.

      The aim is to investigate the effect of CPAP treatment of OSA on circulating A-FABP, and
      other metabolic biomarkers and cardiovascular parameters
    

Intervention name(s): continuous positive airway pressure
Intervention type(s): Device
Intervention description(s): an device to be used during sleep, which was a nasal mask connected to a device with pressure applied to upper airway
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: obstructive sleep apnea; metabolic dysfunction; metabolic syndrome; adipocyte fatty acid binding protein
Time Efficiency and Obturation Quality of Rotary Versus Manual in Primary Teeth
Condition: Endodontic Disease
MeSH terms: Dental Pulp Diseases
Study type: Interventional

Summary: 
      The aim of this study is to evaluate the quality of obturation and the time efficiency of
      rotary versus manual instrumentation in roots of deciduous molars clinically where the:

        -  Primary objective Is to evaluate the time efficiency

        -  Secondary objective Is to evaluate the quality of obturation Clinical and radiographical
           follow up will be performed for 18 months to investigate the clinical and the
           radiographic success for the Conventional and Rotary groups.
    

Detailed description: 
      The study will be conducted in two parts as follows:

      In-vitro part as a training part to practice, test the speed of the rotary system, followed
      by application clinically.

      Obturation will be done using two different filling techniques:

        -  Incremental filling Technique

        -  Disposable syringe Technique.

      Then the instrumentation time and the quality of obturation will be recorded.

      The study will be conducted by recruiting patients from the Outpatient clinic of The
      Pediatric Dentistry and Dental Public Health department, Faculty of Dentistry, Ain Shams
      University:
    

Intervention name(s): NSK Endo motor Endomate; manual K-files
Intervention type(s): Procedure; Procedure
Intervention description(s): Rotary instrumenation used in pulp therapy; manual instrumentation used in pulp therapy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: rotatry instrumentation
CT Data Collection Study
Condition: Cardiac Disease
MeSH terms: Heart Diseases
Study type: Observational

Summary: 
      The primary objective of this study is to gather chest CT images as part of routine clinical
      procedure from subjects with and without prior sternotomy to characterize the substernal
      space. Specifically, the study will provide references for physicians to better understand
      substernal anatomy.
    


Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        The study will enroll up to 100 patients who have taken or plan to take chest CT images
        during routine clinical procedure. The subjects will be divided into sternotomy group and
        non-sternotomy group based on whether the subject had undergone sternotomy.
Emdogain Implementation With Transcrestal Sinus Lifting and Dental Implant Placement
Condition: Osseointegration Failure of Dental Implant; Bone Density Increased
MeSH terms: Osteosclerosis
Study type: Interventional
Phase: Phase 4

Summary: 
      The aim of this study is to evaluate the clinical and radiographic results of implants placed
      using osteotome sinus ﬂoor elevation (OSFE) with and without simultaneous enamel matrix
      derivative (EMD) application.
    

Detailed description: 
      Twenty-four patients will be randomly assigned into two groups: Group I: (EMD+OSFE) (n=20
      implants, 13 patients) OSFE with EMD application, and Group II 8OSFE): (n=20 implants, 11
      patients) OSFE without EMD application. The patients will be recall at 3- and 12- months
      after surgery. The residual bone height (RBH), implant protrusion length (IPL), peri-implant
      sinus bone level (SBL), endo-sinus bone gain (ESBG), implant stability and peri-implant bone
      density values (Hounsfield units) will be assessed.
    

Intervention name(s): Enamel Matrix Protein
Intervention type(s): Drug
Intervention description(s): Enamel matrix derivated is used with transcrestal sinus lifting treatment
Other intervention name(s): emdogain
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: enamel matrix derivated; maxillary sinus
A Study of Intranasal ChAdOx1 nCOV-19
Condition: Coronavirus
MeSH terms: Coronavirus Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      Open label, dose escalation study to investigate:

        1. Safety, tolerability and immunogenicity of one or two doses of intranasal ChAdOx1
           nCOV-19, in vaccine naïve individuals, with randomisation between one and two dose
           groups.

        2. Safety, tolerability and immunogenicity of intranasal ChAdOx1 nCOV-19, given as a
           booster dose in individuals who have had two intramuscular COVID-19 vaccinations.
    

Detailed description: 
      The study will include up to 54 healthy adult participants, divided into five groups. Groups
      1-3 will consist of vaccine-naïve volunteers and groups 4-5 will consist of volunteers who
      have received 2 doses of IM COVID-19 vaccine.

      Groups 1-3 will receive three vaccine dose levels (low i.e. 5x10^9vp, high i.e. 5x10^10 VP,
      and moderate i.e. 2x10^10 VP ChAdOx1 nCOV-19 IN). The low and high dose groups will each have
      safety lead-in subgroups. All volunteers will be consented for receipt of a booster vaccine
      at approximately 4 weeks post first vaccine. All volunteers will be randomly allocated 1:1 to
      receive an intranasal booster vaccine as indicated, stratified by first dose level.

      Group 4 will consist of volunteers who have received 2 intramuscular doses of ChAdOx1
      nCoV-19, at least eight weeks apart, and group 5 will consist of volunteers who have received
      2 intramuscular doses of BNT162b, at least three weeks apart. Both of these groups will
      receive a single standard dose (5x1010vp) on intranasal ChAdOx1 nCOV-19.
    

Intervention name(s): ChAdOx1 nCov-19
Intervention type(s): Biological
Intervention description(s): A single dose of ChAdOx1 nCov-19 delivered intranasally (IN)
Allocation: Randomized
Intervention model: Sequential Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Covid-19; ChAdOx1 nCov19; SARS-CoV-2; Vaccine
Phase II Multicenter, Open-label, Single Arm Clinical Study of Pomalidomide and dexamethasonE and Cyclophosphamide
Condition: Relapsed or Refractory Multiple Myeloma
MeSH terms: Multiple Myeloma
Study type: Interventional
Phase: Phase 2

Summary: 
      Highest treatment efficacy in patients with refractory myeloma may be achieved with regimens
      combining novel agents and alkylating agents. However, in applying this approach the patients
      are at substantial risks of a critical myelosuppression. Pomalidomide demonstrates
      significant activity in combination with Dexamethasone in relapsed or refractory multiple
      myeloma. This trial is an attempt to further improve the efficacy of
      Pomalidomide/Dexamethasone as well as to balance efficacy and toxicity. Integration of
      Cyclophosphamide in the treatment in case of suboptimal response or first evidence of
      progressive disease has the aim to significantly increase duration of treatment that should
      have a positive impact on PFS. It is furthermore an attempt to optimize the potential of
      Pomalidomide in the antimyeloma efficacy. Based on the recent findings, that myeloma is a
      disease with a wide clonal heterogeneity, combination treatment in case of suboptimal myeloma
      control might lead to a more effective suppression especially of aggressive subclones and
      might reduce early resistance. In addition, with the goal of keeping the individual patient
      as long as possible under an effective IMiD treatment, the potential of the drug might be
      optimized according to the current view of maintenance treatment resulting ideally in an
      outgrowth of indolent clones in the bone marrow niche.
    


Intervention name(s): Imnovid (pomalidomide); Dexamethasone; Endoxan (Cyclophosphamide)
Intervention type(s): Drug; Drug; Drug
Other intervention name(s): Pomalyst
Intervention MeSH terms: Dexamethasone; Cyclophosphamide; Pomalidomide
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Randomized, Open-label, Parallel Study to Evaluate the Pharmacokinetic Characteristics of Pregabalin According to Different Controlled Released Formulations in Healthy Male Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this trial is to compare the pharmacokinetic characteristics of YHD1119 A,
      YHD1119 B, YHD1119 C and Lyrica capsule.

      YHD1119 A, B, C are controlled released formulations which are made by YUHAN Corporation.

      Primary endpoints are C max,ss and AUC tau. Secondary endpoints are AUC last, AUC infinity, T
      max,ss, t 1/2
    


Intervention name(s): Pregabalin
Intervention type(s): Drug
Intervention description(s): Pregabalin 300mg a day
Intervention MeSH terms: Pregabalin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Screening
Keywords: To evaluate the pharmacokinetic characteristics of Lyrica, YHD1119 A,B,C
Post-Obturation Pain Following the Use of the AH Plus and iRoot SP Sealers
Condition: Endodontically-Treated Teeth
MeSH terms: Tooth, Nonvital
Study type: Interventional

Summary: 
      The aim of this study was to evaluate and compare postoperative pain and overextension of
      root canal filling after root canal treatment using a carrier-based obturation system and two
      different sealers.

      In this prospective randomized clinical trial, 160 mandibular premolars and molars in 160
      patients were treated. Patients with vital and devital teeth were assigned to four groups
      using a randomized block design with block sizes of 10 patients each. The groups were
      composed of devital teeth with periapical lesions treated with iRoot SP sealer, vital teeth
      treated with iRoot SP sealer, devital teeth with periapical lesions treated with AH Plus
      sealer, and vital teeth treated with AH Plus sealer. In single visits, a single operator
      prepared root canals and filled them with sealer using the carrier-based obturation
      technique. Radiographs were taken and obturation length was recorded. Patients recorded pain
      scores use of Visual Analogue Scale and frequency of analgesic intake at baseline and 0-6,
      6-12, 12-24, and 24-72 h..
    

Detailed description: 
      This randomized controlled clinical study was conducted to compare the incidence and
      intensity of post-obturation pain, evaluate the overextension of filling material
      radiographically, and assess the relationship between pain and analgesic intake in patients
      with vital and devital teeth undergoing carrier-based obturation with two different sealers
      (iRoot SP, AH Plus)
    

Intervention name(s): Root canal obturation with iRoot SP sealer; Root canal obturation with AH Plus Sealer
Intervention type(s): Other; Other
Intervention description(s): Postoperative pain after root canal obturation with iRoot SP sealer with patients who has (mandibular premolar/molar) vital and devital pulps.; Postoperative pain after root canal obturation with AH Plus sealer with patients who has (mandibular premolar/molar) vital and devital pulps.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Endodontic Postoperative Pain; iRoot SP Sealer; Randomized Clinical Trial; Herofill carrier-based obturation
Optimal Timing of Dinoprostone Administration Prior to Office Hysteroscopy
Condition: Dinoprostone Timing
Study type: Interventional
Phase: Phase 3

Summary: 
      The aim of this study is to determine whether dinoprostone administered 10 hours before
      office hysteroscopy can relieve pain more effectively compared with dinoprostone administered
      3 hours before office hysteroscopy.
    


Intervention name(s): long interval dinoprostone; short interval dinoprostone
Intervention type(s): Drug; Drug
Intervention description(s): A small envelope including two labeled plastic bags (A & B) (each bag containing either 1 dinoprostone tablet(3mg) or 1 identically appearing placebo tablet) will be packaged in sequentially numbered sealed envelopes. In long interval dinoprostone group, bag (A) contains dinoprostone tablet and bag (B) contains placebo tablet. After signing the informed consent, the sequentially numbered sealed envelopes will be opened (according to the sequence of attendance of the patient) by the study nurse. Tablets in bag (A) will be inserted 12 hours before office hysteroscopy and tablets in bag (B) will be inserted 3 hours before office hysteroscopy.; A small envelope including two labeled plastic bags (A& B) (each bag containing either 1 dinoprostone tablet(3 mg) or 1 identically appearing placebo tablet) will be packaged in sequentially numbered sealed envelopes. In short interval dinoprostone group, bag (A) contains placebo tablet and bag (B) contains dinoprostone tablet. After signing the informed consent, the sequentially numbered sealed envelopes will be opened (according to the sequence of attendance of the patient) by the study nurse. Tablets in bag (A) will be inserted 12 hours before office hysteroscopy and tablets in bag (B) will be inserted 3 hours before office hysteroscopy.
Intervention MeSH terms: Dinoprostone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Development of Novel Adhesive Sports Tape Modular to Facilitate Use of Discomfort
Condition: Cardiovascular Disease
MeSH terms: Cardiovascular Diseases
Study type: Interventional

Summary: 
      Special metals (e.g. Germanium, Titanium, and π element) can be used to produce far-infrared
      radiation. The applications of these metals in promoting blood circulation are worth
      investigating. This clinical trial recruited subjects for using tape made up of Ge, Ti, and π
      element developed by Green Energy Nano Technology Co., Ltd. We assumed that the experimental
      tape can improve the participants' peripheral blood circulation and their quality of life. In
      this clinical trial, the clinical efficacy and safety of the test products were assessed
      using physical examination and questionnaires.
    

Detailed description: 
      This study is made of two open-labeled, two-arm studies. 20 to 80 years old patient diagnosed
      with varicose veins were included in the study. Besides, patient with the following
      characteristics was excluded: vulnerable group, patient with an open wound at lower limb
      which cannot be taped, unable to express willingness clearly, Dyslexia, and inability to
      ambulate.

      The final number of total participant is 86 participants and 66 out of 86 participants were
      assigned to the first study which is divided into 2 groups, the experimental and control
      group. The experimental group received the experimental tape as treatment, and the control
      group didn't receive any treatment. The participants will fill in the questionnaires
      including visual Analogue Scale and quality of life on the first day of the study, and fill
      the same questionnaires seven days later.

      Furthermore, the rest of the 20 participants were assigned to the second study. The
      researchers evaluate their peripheral blood circulation by Segmental Blood Pressure over
      Pulse Volume Recording (SBP/PVR), Maximum Venous Outflow over Segmental Venous Capacitance
      (MVO/SVC), and Ankle Brachial Index (ABI) before they received the treatment, then the
      researchers inspect the same indexes after they received the treatment right after the first
      tests.
    

Intervention name(s): tape
Intervention type(s): Device
Intervention description(s): Sports tape
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: 2 groups of participant, one of the group took the questionnaire then received the intervention for seven days, then took the same questionnaire again.
The other group took the physical examination and received the intervention immediately, then took the physical examination again when the intervention is on the treating area.
Masking: None (Open Label)
Primary purpose: Treatment
Empowerment Training on Type 2 Diabetes Patients on Empowerment Levels and Clinical Findings
Condition: Diabetes Mellitus, Type 2; Empowerment; Patient Empowerment
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      In this study, the effect of nurse-led empowerment training given to patients with Type 2
      Diabetes on clinical findings and empowerment behaviors will be investigated.
    

Detailed description: 
      The research is a randomized controlled design research that includes a pre-test/post-test
      design. The primary outcome expected in the research; change in empowerment behaviors as a
      result of the training given; secondary outcomes are changes in clinical findings.

      The research universe; All Type 2 diabetes patients who applied to the endocrinology
      polyclinic of a private hospital in Eskisehir city center between March-July 2019 consisted
      of. In the study, the sample was randomly selected, and it was aimed to reach all patients
      with Type 2 diabetes who were 18 years of age and older, with a diagnosis period of one year
      or more.

      In the study, patients were randomly assigned to the intervention group, which included 6
      weeks of training, or to the control group, which was on a 6-week waiting list. It used a
      question-based format to address the educational, behavioral, and psychosocial needs of
      patients within the scope of a 12-hour empowerment program that lasted for 6 weeks, 2 hours a
      week.

      Education (DSMS (Developing Empowerment-Based Diabetes Self-Management Support)) is planned
      as stated literature.

      Purpose of education: Empowerment as a philosophy of care emphasizes a collaborative approach
      to facilitating behavior change for patients themselves. Empowerment approach; Goal setting
      is a five-step process that provides patients with the knowledge and clarity they need to
      develop and achieve their diabetes and lifestyle goals. The first two steps are to identify
      the problem and identify patients' beliefs, thoughts, and feelings that may support or hinder
      their efforts. The third step is to determine the long-term goals expected from patients. In
      this step, patients are then expected to make a behavioral change that will help them achieve
      their long-term goals. The last step is for patients to evaluate their efforts and determine
      what they have learned in the process. Empowerment training was determined within the
      framework of this process.
    

Intervention name(s): Diabetes self- management education (DSME) program
Intervention type(s): Behavioral
Intervention description(s): We offered a two-hour course each week, comprising of two sessions of lectures (40 minutes each), two breaks (10 min each) and interactive session (20 min). In the interactive session, patients could communicate with each other in groups or raise any questions to the investigators.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care