Chinese Medicine Periodic Therapy for Dysfunctional Uterine Bleeding During Adolescence With Yin Deficiency and Blood Heat Syndrome
Condition: Dysfunctional Uterine Bleeding
MeSH terms: Uterine Hemorrhage; Metrorrhagia; Hemorrhage; Yin Deficiency
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to conduct a randomized, single blind, controlled intervention
      trial to observe the therapeutic effect of kidney-tonifying and tune up Chong-Ren hemostasis
      Chinese medicine periodic therapy for dysfunctional uterine bleeding based on objective
      Chinese and western medicine evaluation standard.
    

Detailed description: 
      Dysfunctional uterine bleeding during adolescence is the most common menstrual disorders
      during adolescence, and the age of children suffering from it tended to be lower. It's urgent
      to explore effective ways to alleviate the pain caused by dysfunctional uterine bleeding.

      In our research, 160 children are randomly divided into a Chinese medication periodic therapy
      group (80 cases) and a Gong Xue Ning control group (80 cases). Paticipants in Chinese
      medication periodic therapy group are treated with kidney-tonifying and tune up Chong-Ren
      hemostasis Chinese medicine for 3 months, whereas the Gong Xue Ning control group received
      Gong Xue Ning capsules for 3 months. We compare the effect of the two therapies about
      hemostasis and menstruation regulation, and the change of the thickness of endometrium, sex
      hormones, Kisspeptin, and PAI-1 in blood before and after the treatment, in order to make
      clear the efficacy and the mechanism of the Chinese medicine periodic therapy.
    

Intervention name(s): Kidney-tonifying and tune up Chong-Ren hemostasis Chinese medicine; Gong Xue Ning capsules
Intervention type(s): Drug; Drug
Intervention description(s): Participants of Chinese medicine periodic therapy group will be treated with kidney-tonifying and tune up Chong-Ren hemostasis Chinese medicine periodic therapy. During bleeding period, use kidney-tonifying, heat-clearing and consolidating channel for hemostasis Chinese medicine to stop bleeding. The kidney-tonifying hemostasis prescription is made up of Nvzhenzi, Hanliancao, Tusizi, Xianhecao, Cebaiyetan, Danpi, Zhimu, etc. When the bleeding stops, use the kidney-tonifying, essence-strengthening and blood-activating, menstruation-regulating Chinese medicine to regulate menstruation. The kidney-tonifying and menstruation-regulating prescription is made up of Shengshudi, Zhimu, Tusizi, Fupenzi, Bajirou, Danggui, Danpi, etc. The drugs are granules for taking after infusion once a day. Participants receive this treatment for 3 months.; Participants of Gong Xue Ning capsules group children will be treated with Gong Xue Ning capsules, 2 capsules 3 times a day during the bleeding period. When the bleeding stops, patients will be treated with Zhi Bai Dihuang pills,8 pills 3 times a day. Participants receive this treatment for 3 months.
Intervention MeSH terms: Hemostatics
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: In our research, 160 children are randomly divided into a Chinese medication periodic therapy group and a Gong Xue Ning control group, and they receive different treatment for 3 month.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment