The Use of Submucosal Dexamethasone After Periodontal Surgery
Condition: Periodontal Pocket; Pain; Swelling/ Edema; Patient Satisfaction; Periodontitis
MeSH terms: Periodontitis; Periodontal Pocket; Edema
Study type: Interventional

Summary: 
      The aim of this study is to evaluate the effectiveness of submucosal 8 mg (2 mL)
      dexamethasone on postoperative pain, swelling, chewing efficiency, trismus, healing, and
      discomfort after periodontal flap surgery
    

Detailed description: 
      Periodontitis is an oral inflamatuar disease caused by specific microorganisms, is
      characterized by attachment loss, alveolar bone resorption, pathological pocket formation.
      This disease causes deep periodontal pockets associated with deep intrabony defects as well
      as various clinical problems. For management overcome these problems, various approaches have
      been proposed in the treatment of periodontitis, including initial periodontal treatment such
      as scaling and root planing, followed by flap surgery, resective bone surgery and periodontal
      regeneration when applicable. However, periodontal flap surgery applied in these approaches
      causes undesirable side effects such as pain and swelling. To overcome these disorders,
      studies continue to investigate by using various medication regimens include pre, intra or
      post operative drugs.

      Dexamethasone is a synthetic steroidal anti-inflammatory drug used to control pain, swelling,
      and inflammation occurring in third molar surgeries, periodontal therapy and periodontal
      surgeries, implant surgery, and endodontic treatment. In the literature, dexamethasone
      application is frequently used in oral surgery before or after third molar tooth extraction.
      There is limited research on dexamethasone applications in periodontal flap surgery. lt has
      been evaluated the effectiveness of oral use of etoricoxib and dexamethasone in preventing
      pain after open flap debridement surgery. Some authors used 4 mg dexamethasone tablets before
      mucoperiosteal flap surgery and reported that the pain level in the dexamethasone group was
      lower than placebo at the 3rd hour. It has been reported positive results where preferred its
      use intravenously in the postoperative management of periodontal surgery. However, to the
      investigators knowledge, there is no study in the literature in which dexamethasone is
      applied submucosally after periodontal flap surgery. Accordingly, the hypothesis of this
      study was that submucosal application of dexamethasone in periodontal flap surgery would have
      a positive effect on pain and patient comfort. In light of all these scientific data, this
      study aimed to evaluate the effect of submucosal dexamethasone application periodontal flap
      surgery on postoperative pain, swelling, chewing efficiency, trismus, healing and discomfort.
    

Intervention name(s): submucosal 8 mg (2 mL) dexamethasone application; submucosal 2 mL 0.9% isotonic sodium chloride application
Intervention type(s): Drug; Drug
Intervention description(s): The mucoperiosteal flap was applied. After operation, submucosal dexamethasone 8 mg (2 mL) was applied to the operation area as a test group.; The mucoperiosteal flap was applied. After operation, 2 mL 0.9% isotonic sodium chloride was applied to the operation area as a control group
Other intervention name(s): Periodontal flap surgery; Periodontal flap surgery
Intervention MeSH terms: Dexamethasone
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: pain; dexamethasone; surgical flaps