ED50 and ED95 of Intrathecal Bupivacaine With or Without Epinephrine for Total Knee Replacement Arthroplasty
Condition: Spinal Anesthesia; Total Knee Replacement Arthroplasty
Study type: Interventional

Summary: 
      This prospective randomized double-blind dose-response study is aimed to investigate the ED50
      and ED95 of intrathecal bupivacaine with or without epinephrine 100 mcg for total knee
      replacement arthroplasty.
    

Detailed description: 
      Patients undergoing total knee replacement arthroplasty are randomly assigned to six
      bupivacaine dose group (6, 7, 8, 9, 10, 11 mg). Combined spinal-epidural anesthesia would be
      performed. The dose would be considered as successful if no epidural supplement was required
      during surgery. A probit analysis will be performed to calculate the ED50 and ED95 of
      intrathecal bupivacaine with or without epinephrine for total knee replacement arthroplasty.

      After these measurements, ED50 and ED95 of bupivacaine with epinephrine would be compared
      with those without epinephrine.
    

Intervention name(s): intrathecal bupivacaine 6 mg with 100 mcg of epinephrine; intrathecal bupivacaine 7 mg with 100 mcg of epinephrine; intrathecal bupivacaine 8 mg with 100 mcg of epinephrine; intrathecal bupivacaine 9 mg with 100 mcg of epinephrine; intrathecal bupivacaine 10 mg with 100 mcg of epinephrine; intrathecal bupivacaine 11 mg with epinephrine 100 mcg; intrathecal bupivacaine 6 mg with 200 mcg of epinephrine; intrathecal bupivacaine 7 mg with 200 mcg of epinephrine; intrathecal bupivacaine 8 mg with 200 mcg of epinephrine; intrathecal bupivacaine 9 mg with 200 mcg of epinephrine; intrathecal bupivacaine 10 mg with 200 mcg of epinephrine; intrathecal bupivacaine 11 mg with 200 mcg of epinephrine
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): intrathecal bupivacaine 6 mg with 100 mcg of epinephrine; intrathecal bupivacaine 7 mg with 100 mcg of epinephrine; intrathecal bupivacaine 8 mg with 100 mcg of epinephrine; intrathecal bupivacaine 9 mg with 100 mcg of epinephrine; intrathecal bupivacaine 10 mg with 100 mcg of epinephrine; intrathecal bupivacaine 11 mg with epinephrine 100 mcg; intrathecal bupivacaine 6 mg with 200 mcg of epinephrine; intrathecal bupivacaine 7 mg with 200 mcg of epinephrine; intrathecal bupivacaine 8 mg with 200 mcg of epinephrine; intrathecal bupivacaine 9 mg with 200 mcg of epinephrine; intrathecal bupivacaine 10 mg with 200 mcg of epinephrine; intrathecal bupivacaine 11 mg with 200 mcg of epinephrine
Other intervention name(s): marcaine; epinephrine; marcaine; epinephrine; marcaine; epinephrine; marcaine; epinephrine; marcaine; epinephrine; marcaine; epinephrine; bupivacaine; epinephrine; bupivacaine; epinephrine; bupivacaine; epinephrine; bupivacaine; epinephrine; bupivacaine; epinephrine; bupivacaine; epinephrine
Intervention MeSH terms: Epinephrine; Racepinephrine; Bupivacaine; Epinephryl borate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Keywords: spinal anesthesia; intrathecal bupivacaine; epinephrine; ED50; ED95