bioihbjkbjnl/mcl2 huggingface dataset:
Practicing Self-Control Lowers the Risk of Smoking Lapse
Condition: Behavior, Addictive; Cigarette Smoking
MeSH terms: Behavior, Addictive
Study type: Interventional

Summary: 
      The proposed study will investigate the role of self-control in smoking cessation and whether
      interventions that improve self-control can help reduce the risk of lapsing among smokers who
      wish to quit. Our model predicts that the regular practice of self-control should lead to a
      building of strength and a general improvement in self-control performance. Hence, smokers
      who practice self-control prior to quitting should be more likely to succeed in their
      cessation attempt than smokers who do not practice self-control
    


Intervention name(s): self-control practice
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Neck Fat Accumulation and Its Relationship to Cardiovascular Risk and Metabolic Syndrome
Condition: Obesity
MeSH terms: Metabolic Syndrome
Study type: Observational

Summary: 
      Accumulation of fat in the neck using tape measures has been linked to increased
      cardiovascular risk. The investigators' hypothesis is that detailed measures of neck fat
      using computed tomography will show that specific fat compartments in the neck contribute
      differently to cardiovascular risk.
    


Intervention name(s): No intervention
Intervention type(s): Other
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Retrospective search of whole-body PET/CT examinations and consecutively selected imaging
        studies.
Virtual Reality versusTask-oriented for Gait in CP
Condition: Cerebral Palsy
MeSH terms: Cerebral Palsy
Study type: Interventional

Summary: 
      The children with hemiplegic cerebral palsy had a longer gait cycle, slower walking speed,
      and longer support phase than did the healthy children. The support phase was longer than the
      swing phase in the children with hemiplegic cerebral palsy
    

Detailed description: 
      This research aims to evaluate the effect of virtual reality (VR) games on balance recovery
      of children with cerebral palsy (CP) by quantitatively synthesizing the existing literature,
      and to further determine the impact of VR game intervention (the duration of each
      intervention, intervention frequency, intervention cycle, and total intervention time) on the
      balance recovery of children with CP.

      A high-intensity task-oriented training programme designed to improve hemiplegic gait and
      physical fitness was feasible in the present study and the effectiveness exceeds a low
      intensity physiotherapy-programme in terms of gait speed and walking capacity in hemiplegic
      cp. In a future study, seems appropriate to additionally use measures to evaluate physical
      fitness and energy expenditure while walking.
    

Intervention name(s): selected physical therapy program
Intervention type(s): Other
Intervention description(s): strengthening muscles of upper and lower limbs, balancing exercise, gait training in open environment, stretching for elbow flexors and forearm pronators,lower limb hip flexors and knee extensor and ankle dorsiflexors
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: G 1 (control) received traditional physical therapy program for 60 min. G 2 (study) received traditional physical therapy program for 30 min. and virtual reality for 30 min.
G 3 (study) received traditional physical therapy program for 30 min. and task oriented training for 30 min.
all groups treated for four successive months.
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: wii sport; task oriented training; hemiplegic cerebral palsy
Conditions Associated With Poorly Controlled Diabetes in Patients With Type 2 Diabetes and HbA1c Changes With Therapy
Condition: Type 2 Diabetes; Poorly Controlled Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Observational

Summary: 
      In Turkey, only 55% of patients with type 2 diabetes have been diagnosed, and 91% of these
      patients have been receiving treatment. The rate of patients reaching the treatment target is
      50%. The pandemic has also affected diabetic patients. We aimed to determine the
      characteristics of patients with type 2 diabetes (HbA1c >=10) with poor metabolic control and
      to evaluate the extent to which metabolic control can be achieved in 3 months.
    

Detailed description: 
      Patients who applied to Istanbul Medeniyet University Goztepe Prof. Dr. Suleyman Yalcin City
      Hospital Diabetes Polyclinics and have an HbA1c levels of >= 10% in their examinations will
      be admitted to the study. Detailed history, including medication usage and previous blood
      tests will be questioned. The patients will be asked to complete questionnaires about their
      eating patterns (mindful eating questionnaire), their physical activities (General practice
      physical activity questionnaire), and whether they have depression (Beck depression
      questionnaire).

      Anthropometric measurements will be taken, and biochemical data will be recorded. Patients
      will be grouped according to their previous HbA1c values as a) newly diagnosed, b) those
      whose diabetes was previously controlled, c) those whose diabetes was previously not at the
      target range but now worsened, and d) those whose diabetes was poorly controlled from the
      beginning.

      Diabetes follow-up will be continued by their respective physicians. The patients will be
      called again three months after their enrollment to record the most recent biochemical data.
      Patient characteristics (age, gender, educational status, depression status, eating
      awareness, exercise characteristics) will be evaluated in accordance with the predetermined
      HbA1c groups. Again, according to the patient groups, the difference in HbA1c after three
      months, the frequency of reaching the target, and possible factors associated with the
      findings will be evaluated.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients who have been diagnosed with type 2 diabetes and have an HbA1c level equal to or
        higher than 10%
      
Keywords: type 2 diabetes; poorly controlled Diabetes Mellitus
Imaging on Core Muscles Function in Patients With Visceral Adiposity
Condition: Obesity, Abdominal
MeSH terms: Obesity, Abdominal
Study type: Interventional

Summary: 
      The purpose of this study is to determine the effect of cavitation ultrasonic lipolysis, RUSI
      guided core muscle exercise and their combination (cavitation ultrasonic lipolysis and RUSI
      guided core muscles exercise) on diaphragmatic excursion, transverse abdominis activation
      ratio, visceral fat thickness and waist circumference in patients with visceral adiposity
      patients with visceral adiposity will be recognized by nutrition specialist. 45 patients were
      distributed randomly into three groups. The first group will be treated with Cavitation
      lipolysis twice weekly. The second group was treated with rehabilitative ultrasound imaging
      (RUSI) guided core muscle exercise. The third group was treated with combination of
      cavitation and RUSI. patients will be examined with medical ultrasound imaging and tape
      measurement.
    

Detailed description: 
      - Inclusion criteria: Forty five subjects participated in this study. Age of participants
      ranged from 25 to 45 years. 3. Waist circumference was more than 102 cm for men and 88 cm for
      women 4. Body mass index (BMI) ranged from 25 to 29.9 (Kg / m2). 5. Subjects hadn't received
      drugs

      Exclusion criteria:

        1. history of spinal surgery or spinal fracture.

        2. Serious diseases, such as heart disease, kidney, liver diseases, gastric ulcer or
           duodenal ulcer.

        3. A history of bronchial asthma or any chest disease.

        4. Uncontrolled diabetes or hypertension.

        5. Patients with peacemaker or any metal implant on the treated area.

        6. Cancer or patient with past history of tumor excision
    

Intervention name(s): device and exercise
Intervention type(s): Other
Intervention description(s): cavitation ultrasonic device therapeutic exercise guided ultrasonography imaging
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Supportive Care
Method Study: Bilateral TAP Block With 24 Hours Infusion
Condition: Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this method study in healthy volunteers is to determine the extent of sensory
      block following Transversus Abdominis Plane (TAP) block with 24 hours infusion of ropivacaine
      versus infusion of saline. Furthermore, to determined the analgesic effect of the TAP block
      and the influence on the lung function.
    


Intervention name(s): Infusion of ropivacaine; Infusion of saline
Intervention type(s): Procedure; Procedure
Intervention description(s): TAP block with ropivacaine 20 ml 0,5%. Catheter with infusion of ropivacaine 0,2% 5 ml/h 24 hours on one side of the abdomen.; TAP block with ropivacaine 0,5% 20 ml. Catheter with infusion of saline 5 ml/h 24 hours.
Intervention MeSH terms: Ropivacaine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Transversus abdominis plane block; postoperative pain; Postoperative pain management
Trial of Ceramic Water Filters to Reduce Cryptosporidium Infection in Kenya
Condition: Cryptosporidium; Diarrhea; Cryptosporidiosis; Communicable Diseases; Diarrheal Disease
MeSH terms: Cryptosporidiosis; Communicable Diseases; Infections; Diarrhea
Study type: Interventional

Summary: 
      The aim of the study is to examine the efficacy of ceramic water filters to reduce the burden
      of waterborne diarrheal illness among infants in selected villages in Kenya. In Kenya very
      young children are given drinking water or water is used in reconstitution of their food. We
      hypothesize that ceramic water filters will remove Cryptosporidium from drinking water
      reducing infection in infants.
    

Detailed description: 
      Diarrhea is a major cause of illness among children in Africa. Cryptosporidium is a protozoan
      waterborne diarrheal pathogen resistant to chlorine. Ceramic filters are effective at
      improving drinking water quality, including removal of protozoa. In a recent preliminary
      analysis of >22,000 children <5 years enrolled in the Global Enterics Multi-Center Study
      (GEMS) case-control study of moderate-to-severe diarrhea, Cryptosporidium was identified as a
      leading cause of diarrhea in infants across all four participating African sites. This pilot
      is the first Cryptosporidium specific intervention trial of household ceramic water filters
      to reduce the burden of cryptosporidiosis acquired through drinking water in rural Kenya.
    

Intervention name(s): Ceramic water filter
Intervention type(s): Other
Intervention description(s): In total, 120 households with a child 4-10 months old will receive a Cera Maji ceramic water filter for treatment of drinking water at initial entry into the study (intervention group), and 120 households with a child 4-10 months old at initial entry into the study will not receive a ceramic water filter (control group). The study duration will be 6 months. All households in the control group will receive a Cera Maji ceramic water filter when the study ends.
Other intervention name(s): Cera Maji ceramic water filter
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Cryptosporidiosis; Waterborne disease; Diarrheal disease; Ceramic water filters; infants; young children; drinking water; Kenya
Effectiveness of the Optifast Program Compared With a Reduced-energy Food Based Diet Plan on Body Weight
Condition: Obesity
MeSH terms: Body Weight
Study type: Interventional

Summary: 
      Compare percent change in loss of body weight between the OPTIFAST program and a food-based
      energy-deficit program
    


Intervention name(s): Optifast; Food-Based
Intervention type(s): Other; Other
Intervention description(s): medically-supervised weight management program; low-energy, low-fat diet
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Clinical Study of Increased Dose of TA-650 in Patients With Psoriasis
Condition: Plaque Psoriasis; Psoriatic Arthritis; Pustular Psoriasis (Excluding a Localized); Psoriatic Erythroderma
MeSH terms: Arthritis, Psoriatic; Psoriasis; Dermatitis, Exfoliative
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to evaluate the efficacy, safety and pharmacokinetics of TA-650
      at increased dose of 10 mg/kg every 8 weeks in patients with psoriasis in whom effect of the
      treatment was confirmed after the treatment with Remicade® at 5 mg/kg every 8 weeks but
      decreased thereafter.
    

Detailed description: 
      -  Patients with plaque psoriasis or psoriatic arthritis:

             1. Screening Period:

                TA-650 at 5 mg per kg body weight is administered on the day of TA-650
                administration at the start (week 0) and week 8 (if efficacy is not judged as
                decreased or maintained at week 8 of the screening period) , respectively, by
                intravenous infusion slowly over at least 2 hours.

             2. Increased Dose Period:

                If efficacy is judged as decreased in the screening period, TA-650 at 10 mg per kg
                body weight is administered on the day of TA-650 administration at the start (week
                0) and at every 8 weeks up to week 32 in the increased dose period , respectively,
                as one dose by intravenous infusion slowly over at least 2 hours.

        -  Patients with pustular psoriasis or psoriatic erythroderma:

      TA-650 at 10 mg per kg body weight is administered on the day of TA-650 administration at the
      start (week 0) and at every 8 weeks up to week 32, respectively, as one dose by intravenous
      infusion slowly over at least 2 hours.
    

Intervention name(s): TA-650
Intervention type(s): Drug
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Infliximab; REMICADE; TA-650; psoriasis
Effects of Chiropractic Adjustments on Brain Function Using Quantitative Encephalography
Condition: Brain Function
Study type: Interventional

Summary: 
      Despite the abundance of theories concerning the effects of chiropractic adjustments on brain
      function, this remains an understudies area for the profession.

      Quantitative Electroencephalography (qEEG)is a technique that allows for an in-depth analysis
      of brain function. A normative database will be used to compare before, during and after
      effects of chiropractic adjustments on brain function. This will include usage of Low
      Resolution Electromagnetic Tomography (LORETA).

      This study seeks to objectively document effects of chiropractic adjustments on brain
      function.
    


Intervention name(s): Chiropractic adjustment; Sham adjustment
Intervention type(s): Other; Other
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Health Services Research
Keywords: quantitative encephalography; brain computer interface; chiropractic; sacro-occipital technique
Bioequivalence Study of Atazanavir 300 mg Capsule
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this clinical research study is to assess the bioequivalence of atazanavir
      administered as a single 300 mg capsule relative to two atazanavir 150 mg capsules in healthy
      subjects.
    


Intervention name(s): Atazanavir + Ritonavir; Atazanavir + Ritonavir
Intervention type(s): Drug; Drug
Intervention description(s): Capsules, Oral, ATV 300mg as 2-150mg + RTV 100mg, single dose, 7 days washout crossed over to Treatment B.; Capsules, Oral, ATV 300mg as single cap + RTV 100mg, single dose, 7 days washout.
Other intervention name(s): Abilify; Abilify
Intervention MeSH terms: Ritonavir; Atazanavir Sulfate; Aripiprazole
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Psychological and Psychosocial Intervention With War-Affected Children
Condition: Stress Disorders, Post-Traumatic; Depression; Anxiety; Conduct; Pro-social Behavior
MeSH terms: Stress Disorders, Post-Traumatic
Study type: Interventional

Summary: 
      The investigators are interested in knowing whether a group-based, trauma-focused
      intervention (Trauma Focused Cognitive Behavioral Therapy) is superior to a more general, non
      trauma-focused, psychosocial intervention (Child Friendly Spaces) in reducing post-traumatic
      stress, depression and anxiety and conduct problems and increasing pro-social behavior among
      war-affected children in the Democratic Republic of Congo.
    


Intervention name(s): Trauma Focused Cognitive Behavioral Therapy; Child Friendly Space
Intervention type(s): Behavioral; Behavioral
Intervention description(s): 9 sessions of manualised, culturally modified, group-based trauma-focused cognitive behavioral therapy; 9 sessions of a manualised, culturally appropriate, non trauma-focused psychosocial intervention
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Trauma-Focused Cognitive Behavior Therapy; War-affected Children; Post-traumatic Stress Symptoms; Psychosocial Distress
Glutamine Role in Preventing Vaso-occlusive Crisis Among SCD Patients
Condition: Sickle Cell Disease
MeSH terms: Anemia, Sickle Cell
Study type: Interventional
Phase: Phase 4

Summary: 
      Prospective phase IV interventional open label randomized controlled trial to assess safety
      and efficacy of glutamine in preventing vaso-occlusive crisis (VOC) episodes in sickle cell
      pediatrics and adolescents' patients
    

Detailed description: 
      Vaso-occlusive crisis (VOC) episodes are considered to be the cause of 95% of
      hospitalizations for sickle cell disease (SCD) patients. Prior studies have described pain
      management in SCD patients with poor outcomes in the short term and decreased quality of life
      in patients over the long term.

      Although that L-glutamine has been recently approved by the FDA for the prevention of acute
      complications in sickle cell disease. However, there are many gaps in our understanding of
      its therapeutic implications in SCD. This study will assess the safety and efficacy of
      glutamine in preventing vaso-occlusive crisis (VOC) episodes in sickle cell pediatrics and
      adolescents' patients
    

Intervention name(s): L-Glutamine, Oral Powder for Reconstitution; Standard of care
Intervention type(s): Drug; Other
Intervention description(s): Glutamine is an essential amino acid. It will be provided in a powder form. It will be dissolved in at least 8 ounces of hot or cold liquid. It can also be mixed with a soft food such as pudding, applesauce, or yogurt. Then it will be Stirred and then eaten or drunken The Glutamine will be as an add on to the Standard of care; Hydroxyurea 15-25 mg per kg per day and/ or blood transfusion therapy
Other intervention name(s): L-Glutamine Powder
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: glutamine, vasooclussive crisis, sickle cell disease, Egypt
A Study of E6005 in Japanese Patients With Atopic Dermatitis
Condition: Atopic Dermatitis
MeSH terms: Dermatitis, Atopic; Dermatitis; Eczema
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The safety and pharmacokinetics of topical application with E6005 ointment compared to
      vehicle will be evaluated in Japanese male patients with atopic dermatitis. Additionally, the
      efficacy of topical application with E6005 ointment will be explored in Japanese male
      patients with atopic dermatitis.
    


Intervention name(s): E6005; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Four Steps of Ointment Application: Step 1: 0.01% of E6005; Step 2: 0.03% of E6005; Step 3: 0.1% of E6005; Step 4: 0.2% of E6005.; Matching placebo for each step
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Dermatitis; Atopic
Assessment of the Effectiveness of Biodentine® in Pulpotomies Primary Teeth
Condition: Effectiveness of Biodentine® in Pulpotomies Primary Teeth
Study type: Observational

Summary: 
      Clinical and radiographic assessment of Biodentine® as a pulp dressing material for pulpotomy
      treatment in human primary molars.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Healthy children attending the Pediatric Dentistry Clinic of the Hebrew University-Hadassah
        School of Dental Medicine in Jerusalem
      
Keywords: pulpotomy; primary teeth; Biodentine®; formocresol
The Tolerability and Effects of AZD8848 in Allergic Asthma Subjects Challenged With Inhaled Allergen
Condition: Allergic Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 2

Summary: 
      AZD8848 is a new drug that is being tested for the treatment of asthma and allergic rhinitis
      (hayfever). This study will be in two parts and will include 59 asthmatic patients in total.
      The first part will investigate the tolerability and safety of AZD8848 while the second part
      will investigate both the therapeutic effect of AZD8848 and how well patients tolerate the
      drug.
    


Intervention name(s): AZD8848; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Nasal spray, solution 0.6mg/ mL. Once weekly for 7 weeks, 8 doses in total.; Nasal spray, solution. Once weekly for 7 weeks, 8 doses in total.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment