bioihbjkbjnl/mcl2 huggingface dataset:
IgG Dependent Monocyte Activation in Proximal Venous Thromboembolism
Condition: Venous Thromboembolism; Pulmonary Embolism
MeSH terms: Pulmonary Embolism; Embolism; Thromboembolism; Venous Thromboembolism
Study type: Observational

Summary: 
      The primary objective of this study is to search for, in vitro, elements associated with
      IgG-dependent monocyte activation (signaling pathway activation, expression of pro-coagulant
      and pro-inflammatory factors) and to describe their prevalence in female patients with a
      history of proximal venous thromboembolism (proximal deep vein thrombosis or pulmonary
      embolism) compared to control women.
    

Detailed description: 
      The secondary objectives of this study include to compare the IgG-dependent monocyte
      activation profiles as a function of laboratory thrombophilia parameters. Essentially: Is
      IgG-dependent cell activation associated with the presence of anti-phospholipid antibodies
      (or their subtypes?), or do these profiles indicate something beyond the nosology of
      anti-phospholipid syndrome?
    

Intervention name(s): Blood sampling
Intervention type(s): Biological
Intervention description(s): Venous blood will be sampled for laboratory analyses (see outcomes).
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Patient population description: Patients will correspond to cases of proximal venous
        thromboembolism. They will be recruited during consultations conducted for the chronic
        management of a history of proximal venous thromboembolism or thrombophilia following a
        recent history of proximal venous thromboembolism. Venous thromboembolism, outside of acute
        phase episodes, has good symptom stability over time; no difference is to be expected
        between patients with a chronic history of proximal venous thromboembolism and new patients
        coming in for a checkup. Note that these patients may or may not have a history of
        placental vascular disease.

        Healthy volunteer population description: This populations is composed of healthy, female,
        adult volunteers (<50 years in age) that have had at least 1 healthy pregnancy.
      
Keywords: Proximal venous thromboembolism
A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic Function
Condition: Muscular Atrophy, Spinal
MeSH terms: Muscular Atrophy; Muscular Atrophy, Spinal
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a multi-center, open-label, non-randomized, parallel-group, 2-part study to evaluate
      the effect of hepatic impairment on the PK and safety and tolerability of a single oral dose
      of risdiplam compared to matched healthy participants with normal hepatic function.
    


Intervention name(s): Risdiplam
Intervention type(s): Drug
Intervention description(s): 5 milligram (mg) oral dose administered in fasted state
Intervention MeSH terms: Risdiplam
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
ALT-801 in Overweight and Obese Subjects With Type 2 Diabetes Mellitus (T2DM)
Condition: Type 2 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2; Overweight
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a Phase 1, randomized, double-blind, placebo-controlled, parallel group study to
      evaluate the safety and tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of
      ALT-801 and its effects on glucose control in overweight and obese subjects with type 2
      diabetes mellitus (T2DM).
    


Intervention name(s): ALT-801; Placebo
Intervention type(s): Drug; Other
Intervention description(s): Injected subcutaneously (SC); Injected subcutaneously (SC)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Obese; Overweight; T2DM
Clinical Evaluation of a Test for Monitoring Patients Diagnosed With Chronic Myeloid Leukemia (CML)
Condition: Leukemia, Myelogenous, Chronic
MeSH terms: Leukemia; Leukemia, Myeloid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Study type: Observational

Summary: 
      The objective of this study is to establish the performance of an assay that detects mRNA
      transcript levels in patients diagnosed with CML. The study is conducted at locations within
      the United States. Testing is performed on peripheral blood specimens provided by eligible
      enrolled patients. Results from this study will not be used for patient management decisions.
    


Intervention name(s): Xpert BCR-ABL Ultra
Intervention type(s): Device
Intervention description(s): Semi-quantitation of BCR-ABL transcript in patients that have been previously diagnosed with CML
Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Males and females at least 18 years of age who were previously diagnosed with CML from
        primary care clinics.
Storage Temperature and Quality of Leucoreduced Whole Blood
Condition: Trauma; Austere Environment; Blood Bank; Buddy Transfusion
Study type: Interventional

Summary: 
      In a combat situation the need for safe and high-quality blood products is increasing. WB
      (Whole Blood) is used in many trauma situations, but we wish to investigate whether there is
      an even better whole blood product.

      The purpose of this study is to examine the quality of leucoreduced, cold-stored whole blood.
      We also wish to examine the effects of filtration of whole blood without a 1-2 hour
      holding-time (warm-filtration) and the effects of forced filtration. We also wish to explore
      the possibility of using cold-stored WB for production of RCC.

      Analyses are performed with a main focus to investigate function and quality of red blood
      cells and platelets.
    


Intervention name(s): Donation of 1 whole blood unit
Intervention type(s): Other
Intervention description(s): Donation of 450-500 mL of whole blood according to local blood bank procedures and national guidelines.
Other intervention name(s): Terumo IMUFLEX WB-SP collection bag system.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Blood; Whole blood; Cold-storage; Filtration; Transfusion; Platelet-function
Written Versus Verbal Brief Cognitive Behavioral Exposure Therapy
Condition: Written Exposure Therapy; Imaginal Exposure Therapy
Study type: Interventional

Summary: 
      The purpose of the study is to compare the efficacy of two different versions of a brief
      online exposure therapy program for PTSD: written versus verbal trauma narrative recounting
      in reducing PTSD symptom severity. Both treatments will be delivered through an interactive
      online program with coaching from a trained peer support specialist. Treatment will be a
      variable length, such that 4 to 8 sessions will be delivered, depending on each participants'
      rate of PTSD symptom recovery.
    


Intervention name(s): Written Exposure Therapy; Imaginal Exposure Therapy
Intervention type(s): Behavioral; Behavioral
Intervention description(s): In this study, written exposure therapy is delivered in an online format with coaching from trained peer support specialists. Participants will complete 4-8 sessions, depending on their level of symptom reduction (i.e., allow for early termination when low symptom levels are achieved).; Delivery of imaginal exposure in this study will mirror the procedures used in WET. It will be delivered in an online format with coaching from trained peer support specialists. Participants will complete 4-8 sessions, depending on their level of symptom reduction (i.e., allow for early termination when low symptom levels are achieved).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Comparison of Static & Dynamic Back Extensor Endurance Exercises in LBP
Condition: Back Pain
MeSH terms: Back Pain
Study type: Interventional

Summary: 
      This study will help to find the effects of static and dynamic back extensors exercises for
      chronic low back pain.
    

Detailed description: 
      Low back pain (LBP) is a very common health problem worldwide and a major cause of disability
      which affecting performance at work and general well-being. Determine the effects of static
      and dynamic back extensors exercises for chronic low back pain.
    

Intervention name(s): Static extension endurance exercise; Dynamic extension endurance exercise
Intervention type(s): Other; Other
Intervention description(s): Static extension endurance exercise were performed, 10 repetitions with 10 sec hold of each of exercises Heating pad:15 mins TENS: 15 mins
35 min/session, 3 sessions/week for 6 weeks; Dynamic extension endurance exercise with 10 repetitions of each of exercises which has been performed Heating pad:15 mins TENS: 15 mins
35 min/session, 3 sessions/week for 6 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Low Back Pain; Endurance; Static; Dynamic; Exercises; Pain
Lower Limb Function After Spinal Cord Injury
Condition: Spinal Cord Injury
MeSH terms: Spinal Cord Injuries; Wounds and Injuries
Study type: Interventional
Phase: Phase 4

Summary: 
      This is a randomized, experimental study that examines the physiology of central nervous
      system pathways contributing to the control of bilateral movements in individuals with spinal
      cord injuries and promotes the recovery of lower-limb motor function through the use of
      stimulation and locomotor training.
    

Detailed description: 
      This study plans to examine plasticity in corticospinal synapses of lower-limb muscles. it
      has been demonstrated that plasticity elicited at corticospinal synapses in the spinal cord
      result in enhancements in electromyographic (EMG) and force activity in upper-limb muscles.
      The first step in this proposal is to determine if synaptic plasticity can be elicited in
      corticospinal projections targeting lower-limb muscles in humans with SCI.

      We will also study methods to strengthen corticospinal plasticity to promote recovery of leg
      clearance during training. We will use two novel strategies to enhance plasticity in
      corticospinal synapses of lower-limb muscles after SCI: a). administration of an
      N-methyl-D-aspartate (NMDA) receptor agonist (i.e. D-cycloserine), and b). Combine
      NMDA-induced corticospinal plasticity with training (2D lower limb training and locomotor
      training. Corticospinal synaptic plasticity is thought to depend on activation of NMDA
      receptors and D-cycloserine enhances motor skill behaviors in animals and humans will be
      enhanced by NMDA-induced corticospinal plasticity. An important strength of this aim is the
      combination of training and strategies that aimed at enhancing the synaptic efficacy of
      residual corticospinal projections. Training effects on physiological pathways will be
      explored and correlated with locomotor function
    

Intervention name(s): D-Cycloserine; Placebo; Training; Stimulation; Placebo Stimulation
Intervention type(s): Drug; Drug; Other; Other; Other
Intervention description(s): 100 mg of Seromycin by mouth will be administered; placebo pill will be administered instead of medication by mouth; walking around a designated track at different speeds both forward and backward; magnetic stimulation and electrical stimulation may be applied; this is a fake stimulation that is administered but will be unknow to the subject.
Other intervention name(s): Seromycin; Placebo Drug
Intervention MeSH terms: Cycloserine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: SCI
Cannabinoid Augmentation of Fear Response in Humans
Condition: Fear Conditioning
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The purpose of this double blind, randomized, controlled, proof-of-concept study is to test
      the effects of cannabinoid receptor augmentation on the facilitation of fear conditioning. On
      three days over not more than two weeks, subjects will be trained to associate cues with two
      different stimuli, then this association will be extinguished. Cannabinoid receptor
      stimulation will be accomplished indirectly by harnessing the brain's capacity to
      endocannabinoids through the administration of an enzyme (FAAH inhibitor) that prevents
      degradation of anandamide. Subjects will receive placebo or the FAAH-inhibitor PF-04457845.
      Some details of this study have not been disclosed to preserve the study design.
    


Intervention name(s): PF-04457845; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Acquisition of conditioning Administration of drug Extinction of conditioning; Acquisition of conditioning Administration of placebo Extinction of conditioning
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
Keywords: Fear Conditioning; Cannabinoids; Fear Response
Effect of Dermal Rejuvenation on the UVB Response of Geriatric Skin
Condition: Pre-cancerous Geriatric Skin
Study type: Interventional

Summary: 
      The objective of this study is to examine the ability of dermal rejuvenation therapies to
      protect geriatric skin from ultraviolet light (UVB)-induced carcinogenesis. Skin cancers
      (including basal cell carcinoma and squamous cell carcinoma) are the most common types of
      malignancy and are related to UVB exposure in sunlight. UVB-irradiation of skin causes
      specific DNA damage to keratinocytes that can lead to cancer-causing mutations if they are
      allowed to persist in proliferating cells. Moreover, the incidence of skin cancers is much
      greater in elderly over younger individuals. The objective of the present study is to build
      upon our previous data and test the effect of a non ablative Nd:YAG laser (LaserGenesis) of a
      localized area of skin on dermal IGF-1 production and UVB-mediated keratinocyte effects.
      Treatment of skin using a non ablative high-peak power microsecond pulsed 1064 nm Nd:YAG
      laser (Cutera's LaserGenesisTM laser) leads to papillary dermal heating. The laser targets
      the microvasculature and stimulates collagen production while protecting the epidermis.
      Generally, Laser Genesis is used clinically to improve irregularities in the contour,
      texture, and color of the skin. Laser Genesis is also used to help treat photoaging by
      increasing collagen formation, suggesting that it stimulates fibroblast activity and thus
      possibly increases levels of protective IGF-1.
    


Intervention name(s): UV Light (Laser Genesis)
Intervention type(s): Device
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Biomechanics of Lumbar Region in Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Observational [Patient Registry]

Summary: 
      The purpose of this study was to examine the relationship between non-specific low back pain
      (NSLBP) and lumbar lordosis angle (LLA) and lumbar muscle thickness (LMT) by evaluating
      magnetic resonance images (MRI) in individuals with LBP.
    

Detailed description: 
      The study included a total of 96 individuals, 43 males, and 53 females, who applied to the
      Department of Radiology of the Karabuk University Training and Research Hospital between
      March-June 2019 with complaints of LBP. Individuals' sociodemographic information and medical
      history were recorded using the LBP assessment form. The Oswestry LBP Disability
      Questionnaire was used for LBP. Thickness measurements of muscle (m.) psoas major, m.
      multifidus, m. quadratus lumborum and m. erector spinae were taken on MRI corresponding to
      the L3-L4 vertebra level. Cobb Angle method was used for LLA determination. Measurements were
      made in three repetitions using the Radiant DICOM viewer program, and their averages were
      recorded.
    

Observational model: Other
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        The study included a total of 96 individuals, 43 males, and 53 females, who applied to the
        Department of Radiology of the Karabuk University Training and Research Hospital between
        March-June 2019 with complaints of LBP.
      
Keywords: Low Back Pain; Lumbar Lordosis Angle; Magnetic Resonance Imaging; Muscle Thickness
Effects of High-Intensity Interval Training (HIT) While in a Hyperoxic-Hyperbaric Environment on Exercise Performance
Condition: Exercise Performance
Study type: Interventional

Summary: 
      Hyperbaric oxygen has previously been tested as a possible means for pre-conditioning to
      enhance exercise performance. This study is designed to examine the effects of exercising in
      a hyperbaric chamber for improving fitness when combined with high-intensity training.
    

Detailed description: 
      The purpose of this research study is to determine the incremental benefit of high intensity
      interval training (HIT) in a hyperbaric-hyperoxic environment with HIT alone in healthy
      subjects and to compare the effect of HIT at an intermediate altitude (SLC, UT; altitude 1420
      m) with that performed at sea-level (Durham, NC) in healthy subjects. While VO2 max is
      determined by the functional interdependence of the respiratory, cardiovascular and muscular
      systems, ultimately VO2 max is determined by mitochondrial oxidative capacity. Exercise
      training increases mitochondrial capacity. There is evidence that high intensity interval
      training (HIT) programs are effective at increasing exercise capacity. Furthermore, there is
      evidence that training while in a hyperbaric-hyperoxic environment may potentiate the HIT
      training effect through its effects on mitochondrial oxidative capacity, but this has not
      been scientifically tested. Our hypothesis is that high intensity interval training (HIT) in
      a hyperoxichyperbaric environment performed six-times over a two-week period will increase
      exercise performance compared with HIT performed in ambient conditions in healthy subjects.
      The primary outcome studied will be the effect of high-volume interval training in a
      hyperbaric-hyperoxic on VO2max.
    

Intervention name(s): Hyperbaric chamber; Ambient pressure
Intervention type(s): Other; Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: high intensity interval training; hyperbaric oxygen
Investigation of the Effects of Temporal Adaptation Approach in Post-Discharge Stroke Individuals
Condition: Stroke
MeSH terms: Stroke
Study type: Interventional

Summary: 
      Abstract Introduction: Stroke is a disease that makes it difficult to participate in daily
      life activities by creating functional losses. Healthy temporal adaptation can increase and
      support engagement in meaningful activities. This study aims to analyze the effect of the
      temporal adaptation approach on the post-discharge occupational engagement of individuals
      with stroke.

      Methods: This study is a randomized controlled trial with 1 month follow-up. While the TAA
      approach was applied to the first group, the general condition of the second group was
      followed during the study. Canadian Occupational Performance Measue was administered to
      assess occupational performance and satisfaction, and Occupational Balance Questionnaire was
      for occupational balance.

      Kewords: Time, stroke, rehabilitation, human activities, participation
    


Intervention name(s): Temporal Adaptation Approach
Intervention type(s): Behavioral
Intervention description(s): the temporal adaptation: It includes giving importance to the use of time, choosing meaningful activities, adjusting the time used during these activities and improving it. Such adaptation serves to improve an individual's quality of life, health, and occupational participation.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Rehabilitation, human activities, participation
A Phase 1, Multicenter, Open-Label Study to Evaluate the Effect of Mild or Moderate Hepatic Impairment on the Multiple-Dose Pharmacokinetics of Ozanimod
Condition: Liver Diseases; Digestive System Diseases
MeSH terms: Liver Diseases; Digestive System Diseases; Gastrointestinal Diseases
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a Phase 1, multicenter, nonrandomized, open-label, parallel-group study in
      participants with mild or moderate hepatic impairment, and in participants with normal
      hepatic function.

      Degrees of hepatic impairment will be determined during screening by the participant's score
      according to Pugh's Modification of Child's Classification of Severity of Liver Disease.

      Participants will be enrolled in Groups 1 through 3 as follows:

        -  Group 1 (mild hepatic impairment): A total of approximately 8 participants with a
           Child-Pugh score of 5 to 6.

        -  Group 2 (moderate hepatic impairment): A total of approximately 8 participants with a
           Child-Pugh score of 7 to 9.

        -  Group 3 (normal hepatic function): Approximately 8 to 16 participants will be matched to
           Participants in Groups 1 and 2. Normal hepatic function participants are allowed to
           match multiple hepatic impairment participants. Participants will be matched by sex, age
           (± 10 years), weight (± 20%), and smoking status.
    


Intervention name(s): Ozanimod
Intervention type(s): Drug
Intervention description(s): Ozanimod
Other intervention name(s): RPC-1063, Zeposia
Intervention MeSH terms: Ozanimod
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Mild and moderate Hepatic impairment; Healthy volunteer; Ozanimod
Effects of Chloral Hydrate on Induction, Maintenance, and Recovery From Sevoflurane Anesthesia in Day-case Pediatric Surgery
Condition: Pediatric
Study type: Interventional

Summary: 
      Effects of Choral Hydrate on Induction, Maintenance, and Recovery from Sevoflurane Anesthesia
      in Day-case Pediatric Surgery
    


Intervention name(s): chloral hydrate
Intervention type(s): Drug
Intervention description(s): 30 min before the induction of anesthesia, chloral hydrate (40 mg/kg) or placebo was administered to the children orally.
Intervention MeSH terms: Chloral Hydrate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Keywords: pediatric patients; ASA physical status I or II; aged between 1-5 yrs