bioihbjkbjnl/mcl2 huggingface dataset:
Reconstructive of Multiple-digit Soft-tissue Defects Using Regional Dorsal Digital Flaps
Condition: Finger Injuries
MeSH terms: Finger Injuries
Study type: Interventional

Summary: 
      Reconstruction of soft-tissue defects in multiple digits poses a significant challenge. This
      article reports simultaneous reconstruction of multiple small-to-moderate soft-tissue defects
      using regional dorsal digital island flaps and evaluated the efficacy of their application in
      such complex situation. A retrospective study will be conducted with 26 patients who had
      multiple-digit soft-tissue defects treated with regional dorsal digital island flaps. At the
      final follow-up, we will evaluate the efficacy of their application in such complex
      situation.
    

Detailed description: 
      For the recipient where sensory restoration is important, sensation of the flaps is assessed
      using static two-point discrimination (2PD) and Semmes-Weinstein monofilament (SWM) testing
      at final follow-up. The cold intolerance of the injured finger is measured using the
      self-administered Cold Intolerance Severity Score questionnaire that was rated into mild,
      moderate, severe, and extreme (0-25, 26-50, 51-75 and 76-100). The pain of the injured finger
      is given subjectively by the patient using a grading system that included grade 1, none;
      grade 2, mild, no interference with daily activities; grade 3, moderate, patient works but
      has some limitation in use of the hand because of pain; and grade 4, severe, cannot work or
      use hand. To sum up, patients report their satisfaction with functional recovery of the
      injured finger according to the Michigan Hand Outcomes Questionnaire that was based on a
      5-point response scale.
    

Intervention name(s): flap transferring
Intervention type(s): Procedure
Intervention description(s): we use regional dorsal digital flaps for simultaneous reconstruction of multiple-digit soft-tissue defects
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: soft-tissue defects; dorsal branch of the digital artery; regional flap
Fixed 100 mg Every Evening of Flibanserin vs Placebo in Premenopausal Women With Hypoactive Sexual Desire Disorder
Condition: Sexual Dysfunctions, Psychological
MeSH terms: Sexual Dysfunctions, Psychological
Study type: Interventional
Phase: Phase 3

Summary: 
      The object of this trial is to assess the safety and efficacy of a 24 week course of
      flibanserin for the treatment of hypoactive sexual desire disorder in premenopausal women.
    


Intervention name(s): Flibanserin; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): patients will be randomized to flibanserin or placebo in a double-blind manner; patients will be randomized to flibanserin or placebo in a double-blind manner
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Project Step II: The Effects of Incentives and Feedback on Promoting Walking Within Overweight and Obese Adults
Condition: Physical Activity; Sedentary Lifestyle; Overweight and Obesity
MeSH terms: Overweight
Study type: Interventional

Summary: 
      This study will evaluate the main effects of daily vs. weekly feedback and contingent vs.
      non-contingent incentives for increasing walking behavior among overweight and obese adults.
    

Detailed description: 
      Approximately 68% of adults are overweight or obese, which is associated with increased risk
      for health conditions, including cardiovascular disease, type 2 diabetes, and cancer. These
      individuals are more often sedentary than the general population, which compounds the risk
      for these same conditions. While the benefits of engaging in physical activity are
      well-established, few individuals are able to successfully increase activity to recommended
      levels. Existing intervention programs, often derived from theories such as social cognitive
      theory or related theories, have had limited success. Behavioral economics offers a promising
      alternative, suggesting that engagement in any behavior is based on the maximizing utility
      and happiness (i.e., weighing the cost and benefit of the behavior). Interventions based on
      this theory aim to increase the immediate benefit of engaging in physical activity, often
      using a financial incentive.

      This study will last for 8 weeks. All participants will have the use of a FitBit for ongoing
      self-monitoring and a personalized step-count goal designed to help increase daily steps.
      Participants will receive feedback on reaching their goals either daily or weekly.
    

Intervention name(s): Non-contingent incentives; Contingent incentives; Weekly feedback; Daily feedback
Intervention type(s): Behavioral; Behavioral; Behavioral; Behavioral
Intervention description(s): Incentives are provided for participation; Incentives are provided for attaining daily goals; Text message feedback is delivered weekly summarizing the past week's progress; Text message feedback is delivered daily summarizing the current day's progress
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of 2-Week Nightly Moderate Hypoxia on Glucose Tolerance in Individuals With Type 2 Diabetes
Condition: Type 2 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypoxia
Study type: Interventional

Summary: 
      The purpose of this study is to determine if 2 weeks of nightly exposure (7-12 hours per
      night) to moderate hypoxia (~2,400 meters or 7,500 feet) improves glucose metabolism in
      people with type 2 diabetes.
    

Detailed description: 
      Exposure to hypoxia has been advocated as a possible therapeutic aid against obesity. Indeed,
      our laboratory has provided the first evidence that intermittent, nightly exposure to
      moderate hypoxia is beneficial in improving insulin sensitivity in healthy obese patients
      and, therefore, lowers the risk of developing type 2 diabetes. Benefits included reduced
      fasting glucose levels and improved whole-body (skeletal muscle) and hepatic insulin
      sensitivity. Whether such intermittent hypoxia improves glucose metabolism in people with
      type 2 diabetes is unknown.
    

Intervention name(s): Hypoxico Altitude Training Systems
Intervention type(s): Device
Intervention description(s): Participants will sleep in a tent (which will fit his/her personal mattress) simulating an altitude of ~2,400 meters for 7-12 hours each night for a period of 14 days. Baseline testing measures will include a oral glucose tolerance test (OGTT) and body composition (iDXA). Post-treatment testing measures will include OGTT only.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Impact of Intraoperative Systemic Lidocaine Infusion on Chronic Postoperative Pain After Video-assisted Thoracic Surgery (VATS)
Condition: Lung Cancer(Primary, Metastatic); Benign Lung Mass Requiring Operation
Study type: Interventional

Summary: 
      Systemic lidocaine infusion may improve the patients' chronic post surgical pain after
      video-assisted thoracic surgery
    


Intervention name(s): Systemic intravenous lidocaine infusion; Normal saline infusion
Intervention type(s): Drug; Drug
Intervention description(s): In group L, intravenous lidocaine infusion(0.1mg/kg) for 10minutes after induction of anesthesia. After 10 minutes, lidocaine infusion continued at rate of 3mg/kg/hr during operation, and discontinued before move the patients to PACU.; In group C, the patients receive same volume of normal saline
Intervention MeSH terms: Lidocaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Supportive Care
Keywords: Systemic lidocaine; postoperative pain; Video-assisted thoracic surgery; VATS
Phase I, Exploratory, Single Centre, Single Oral Dose AZD9668 and Intravenous Microdose of [C14] AZD9668, Healthy Subject
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of this study is to assess the absolute bioavailability and to evaluate
      pharmacokinetic parameters of a single oral dose and a radiolabelled intravenous microdose of
      [14C]AZD9668 in healthy male subjects.
    

Detailed description: 
      This is an exploratory study to assess the absolute bioavailability of a single oral dose of
      AZD9668 with respect to an intra-venous microdose of [14C]AZD9668 in healthy male subjects.
    

Intervention name(s): AZD9668
Intervention type(s): Drug
Intervention description(s): Tablets of AZD9668 and IV dose of [C14]AZD9668
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Safety; tolerability; healthy; microdose
Treatment of Pain and Autonomic Dysreflexia in Spinal Cord Injury With Deep Brain Stimulation
Condition: Pain; Autonomic Dysreflexia
MeSH terms: Spinal Cord Injuries; Autonomic Dysreflexia
Study type: Interventional

Summary: 
      The purpose of this research study is to determine if DBS is a feasible, safe and effective
      therapy for pain and autonomic dysreflexia after spinal cord injury.
    


Intervention name(s): Deep Brain Stimulation
Intervention type(s): Device
Intervention description(s): Local anesthesis, MRI and CT scan of the brain followed by implantation of the stimulation device
Other intervention name(s): The Medtronic Models 3387 and 3389 DBS Leads neurostimulation system for deep brain stimulation.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Device Feasibility
Environmental Stress and Individualized Sensorimotor Care on Autonomic Nervous System Activity in Premature Population
Condition: Premature Birth
MeSH terms: Premature Birth
Study type: Observational

Summary: 
      Autonomic nervous system (ANS) is an essential regulator for the homeostasis, circulatory and
      respiratory systems. Heart rate variability, under the dependence of the parasympathetic and
      orthosympathetic arms is a peripheral witness of its well functioning.

      Activity ANS indices are technically measurable from the birth by non invasive cardiac
      monitoring: in given environmental conditions. According to the individualized care given to
      the baby, we can easily observe by frequential analysis, modifications of ANS level activity;
      If for a full-term newborn, the balance of ANS allows him to adapt its cardiac frequency to
      its internal and external environment (thermoregulation, baroreflex, sinus arrhythmia,
      awakening state) , the premature birth is at the origin of a prolonged defect of global ANS
      maturation, probably induced by external environmental and stress factors (pain,
      stimulations, aggressive noise and lights). This disrupted maturation profile in case of
      prematurity, was confirmed in two preliminary studies on premature babies reaching term for
      gestational age.

      We hypothesis that adapted sensorimotor care could decrease this stress and optimize the ANS
      activity profile.

      In a prospective study, by a non invasive real-time measure, we analyse impact of stress on
      ANS activity in a premature population, hospitalized in our neonatal intensive care units.
    


Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Premature Birth
      
Keywords: premature; newborn; heart rate variability; individualized sensorimotor care; noise
Exercise Dose-response and Protein Requirements
Condition: Exercise Training
Study type: Interventional

Summary: 
      Study will investigate the impact of training volume on protein metabolism to estimate the
      impact on daily protein requirements of endurance athletes.
    


Intervention name(s): Endurance exercise
Intervention type(s): Other
Intervention description(s): On the trial day before commencing the indicator amino acid oxidation metabolic trial, participants will either rest, perform a 10km run on a treadmill, or perform a 20km run on a treadmill.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
To Identify the Proportionality of Respiratory Work Under Different NAVA Level
Condition: Respiratory Failure
MeSH terms: Respiratory Insufficiency
Study type: Observational

Summary: 
      The primary purpose of mechanical ventilation is to sufficiently unload the respiratory
      muscles and maintain adequate ventilation in spontaneously breathing patients. When the
      mechanical ventilatory assist is synchronized to the patient's inspiratory effort, both the
      patient and the mechanical ventilator will contribute to the lung-distending pressure,
      necessary to overcome inspiratory load and generate the tidal volume (Vt). Unfortunately,
      conventional modes of mechanical ventilation cannot quantify the impact of the ventilatory
      assist performed by the ventilator and the patient. Inadequate levels of assist are
      associated with adverse effects such as development of fatigue or patient-ventilator
      dissynchrony and diaphragm impairment, and over assist also lead to diaphragm atrophy and
      weaning delay.

      The newly introduced neurally adjusted ventilatory assist (NAVA) has made it possible to
      measure the neural activity of the respiratory centers (expressed by the diaphragm electrical
      activity, EAdi). EAdi is a validated variable to quantify the neural respiratory drive,
      little is known about its usefulness to evaluate the contribution of the patient's
      inspiratory muscle effort relative to that of the mechanical ventilator, which would be of
      crucial importance to appropriately titrate the level of assist.

      During NAVA, the patient's efficiency to transform neural effort (EAdi) into Vt, expressed as
      neuroventilatory efficiency (NVE), may be a useful predictor for determining the contribution
      of the patient and the ventilator to generate a breath.
    


Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        patient with respiratery failure need mechinical ventilation, and will be tolerance short
        time loe level support ventilation
Technology-Enabled Collaborative Care for Youth
Condition: Psychosis; Metabolic Disease; Cardiovascular Risk Factor
MeSH terms: Metabolic Diseases
Study type: Interventional

Summary: 
      The overall objective is to develop scalable interventions to address the physical health
      needs of patients affected by early psychosis. The objective of this project is to conduct a
      feasibility study of a high intensity technology-enabled collaborative care model (CCM)
      compared to lower intensity self-help modules and email support for early identification and
      treatment of cardio-metabolic risk factors in youth, ages 16-29, affected by early psychosis.
    


Intervention name(s): Low Intensity Intervention; High Intensity Intervention
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Participants will have access via the online platform to the NAVIGATE self-help modules for physical activity, nutrition and quitting smoking with a list of community resources. Subjects will be sent a standard reminder emails once per week to complete their modules and connect with their main provider for any assistance.; Participants will receive individualized treatment planning, in collaboration with a Care Coordinator, and the Virtual Care Team (VCT). Interactive modules on physical activity, nutrition and quitting smoking will be provided via the online platform. the virtual team will be engaged to provide treatment and/or recommendations regarding the following: increasing physical activity, improving nutrition and diet, smoking cessation (psychosocial support plus medications), and medication adherence. Participants in this arm will have weekly check-ins with their assigned Care Coordinator where they will be able to discuss VCT recommendations, and progress on their goals.
Other intervention name(s): TECC-Y
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Assessing the Symptoms of Obstructive Sleep Apnea
Condition: Obstructive Sleep Apnea
MeSH terms: Apnea; Sleep Apnea Syndromes; Sleep Apnea, Obstructive
Study type: Observational

Summary: 
      The purpose of this study is to investigate the correlation between health outcomes
      associated with the severity of obstructive sleep apnea (OSA) symptomatology, the findings
      will guide the design of interventional studies.
    

Detailed description: 
      Obstructive sleep apnea is a condition characterised by periods of narrowing of the
      pharyngeal airways during sleep causing hypoxic and hypercapnic episodes with the cessation
      of ventilation. Considering the high number of overweight and obese individuals in Western
      society the understanding of the pathomechanisms behind OSA are important. This observational
      study aims to investigate the correlations between the severity of Obstructive Sleep Apnea
      assessed by the apnea-hypopnea index (AHI) and different health outcomes associated with the
      OSA.
    

Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Mild to severe recently diagnosed Obstructive Sleep Apnea patients selected by physician
        who have not received any treatment for their condition. Selected from Ysbyty Gwynedd in
        North Wales.
      
Biospecimen description: 
      Blood serum
    
Keywords: Obstructive sleep apnea; correlation; AHI; symptoms; mechanisms
Prediction of Postoperative Acute Kidney Injury in Patients With Acute Type A Aortic Dissection Using Cystatin C
Condition: Aortic Dissection; Acute Kidney Injury
MeSH terms: Acute Kidney Injury; Aortic Dissection; Wounds and Injuries
Study type: Observational

Summary: 
      The research aimed to predict postoperative acute kidney injury in patients with acute type A
      aortic dissection preliminarily by exploring the correlation of preoperative cystatin C level
      and incidence of postoperative acute kidney injury and combining with relevant risk factors.
    


Intervention name(s): postoperative acute kidney injury; none postoperative acute kidney injury
Intervention type(s): Other; Other
Intervention description(s): patients suffered postoperative acute kidney injury; patients did not suffered postoperative acute kidney injury
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        patients sufferred acute type A aortic dissection
Evaluation of the Effectiveness of Fibrous Foods, Sugar-free Gomes and Rolly Brush® in the Dental Biofilm Removal
Condition: Self Cleaning
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The objective of this study was to evaluate the efficacy of three methods for removal of
      dental biofilm when compared to dental toothbrushing control. Twenty patients were diagnosed
      and randomized into four groups according to the method tested: 1) apple 2) Rolly Brush 3)
      chewing gum and 4) brushing control. Subjects were evaluated four times according to the
      method used. All were evaluated before performing any method and after using each of the four
      methods separately. The patient's evaluation interval was 24 hours between the use of the
      methods. In the first stage, they underwent a clinical examination in which the needs of
      supragingival scraping or definitive restorations and prophylaxis were detected. After this
      step, all methods of oral hygiene and the consumption of fibrous foods and chewing gum were
      suspended for twenty-four hours. In the second stage, with a minimum of twenty-four hours
      after the first, volunteers received approximately 10 ml of basic fucsin to perform a
      mouthwash. The dental examination was then carried out for measurement on each dental surface
      and the plaque index was recorded on each surface. In the latter, four evaluations were
      performed with at least a 24-hour interval until the patients used the four methods
    


Intervention name(s): Comparison of dental biofilm removal.
Intervention type(s): Device
Intervention description(s): Comparison of the use of 4 methods for dental biofilm removal
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Device Feasibility
Nebivolol and Endothelial Regulation of Fibrinolysis (NERF)
Condition: Prehypertension; Hypertension
MeSH terms: Prehypertension
Study type: Interventional
Phase: Phase 4

Summary: 
      The investigators hypothesize that nebivolol will improve endothelial t-PA release in adult
      humans with elevated blood pressure to a greater extent than either metoprolol or placebo.
      The investigators further hypothesize that the improvement in the capacity of the vascular
      endothelium to release t-PA with nebivolol is mediated, in part, by the compound's
      antioxidant properties.
    


Intervention name(s): Nebivolol; Metoprolol; Placebo; Bradykinin; Saline; Vitamin C
Intervention type(s): Drug; Drug; Drug; Other; Other; Other
Intervention description(s): 5 mg tablet to be taken by mouth once per day for 12 weeks; 100 mg tablet to be taken by mouth once per day for 12 weeks; Gelatin capsule to be taken by mouth once per day for 12 weeks; Bradykinin is infused into the brachial artery at doses of 12.5, 25.0 and 50.0 ng/100 mL of forearm tissue /min. BDK stimulates the endothelial cells to release tissue type plasminogen activator (t-PA). Blood flow in mL/100 mL tissue/min is also measured to BDK.; Baseline or resting forearm blood flow is measured in response to saline for 5 minutes before each drug infusion. t-PA release in response to the saline is also measured.; The acute effects of into-arterial vitamin C on the ability of the endothelium to release t-PA was determined before and after the nebivolol and metoprolol intervention. After allowing sufficient time (~20 minutes) for FBF and plasma t-PA concentrations to return to baseline following the initial infusion of BDK, vitamin C (24 mg/min) was infused at a constant rate while the BDK dose-response curves were repeated. t-PA and FBF were measured.
Other intervention name(s): Bystolic; Toprol-XL; BDK
Intervention MeSH terms: Metoprolol; Nebivolol; Bradykinin; Kininogens
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Other