Beijing Vascular Disease Patients Evaluation STudy
Condition: Vascular Disease
MeSH terms: Vascular Diseases
Study type: Observational [Patient Registry]

Summary: 
      Arteriosclerotic vascular-related diseases have become a serious threat to human health. The
      prevention and reversal of vascular events has become an important direction of medicine.
      Early vascular disease detection system includes pulse wave velocity (PWV), carotid
      intima-media thickness (IMT) and coronary flow velocity reserve (CFVR), flow-mediated
      vasodilation (FMD), cardio-ankle vascular index (CAVI), ankle-brachial index (ABI), insulin
      resistance index (HOMA-IR), hypersensitivity C- reactive protein (hs-CRP), plasma
      homocysteine (Hcy), B-type natriuretic peptide (BNP), uric acid (UA), and so on. However,
      there is no international and domestic comprehensive study on simple and practical evaluation
      system by jointing application of these evaluation indexes to detect vascular disease.
      Combined evaluation function can simultaneously detect and evaluate vascular abnormalities,
      make up a single indicator shortcoming in clinical applications from multiple levels of
      vascular structure and function. However, all indicators testing not only cause time
      consuming, but also increase the burden on patients, resulting unnecessary waste of medical
      resources. Thus, the present study was to select appropriate indicators and effective joint,
      and establish the rating system, using the vascular system to predict the incidence of
      terminal events, and compare this system with the previous scoring system such as FRS
      (Framingham Risk Score) pros and cons.
    

Detailed description: 
      This study aimed to establish vascular disease early detection system and scoring systems by
      comprehensive vascular disease risk factors and vascular function evaluation index. And
      prevention of vascular-related diseases, high-risk groups through positive lifestyle changes:
      such as lipid-lowering, smoking cessation, reversing early vascular lesions, to avoid
      end-stage vascular events.

        1. Detection of vascular function indicators include: PWV, IMT, CFVR, FMD, CAVI, ABI,
           LDL-C, HOMA-IR, hs-CRP, Hcy, BNP, UA and so on.

        2. Design the questionnaire: surveying the lifestyle, personal history, family history of
           the study population.

        3. Follow-up:2 years of observation, recording the end time of vascular events, including
           cardiovascular events (acute myocardial infarction, angina, coronary reperfusion
           therapy), stroke, heart failure, peripheral vascular disease.

        4. Statistics: Complex the factors of vascular disease, screen for an effective indicator
           to predict cardiovascular events, and based on the weight of the different factors, the
           establish the rating system, use the system to predict the incidence of vascular events
           terminal, and compare the system with the previous scoring system such as FRS
           (Framingham Risk Score).
    

Intervention name(s): Questionnaires and follow-up
Intervention type(s): Other
Intervention description(s): Detecting the vascular functional parameters, questionnaire and follow-up: For 2 years or the occurrence of vascular events end time, including cardiovascular events (acute myocardial infarction, angina, coronary reperfusion therapy), stroke, heart failure, peripheral vascular disease.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Subjects such as patient or inpatient patients , aged 45-75 years ,in high-risk vascular
        events groups ,and from Dongcheng District, Shijingshan Shougang community and Mentougou
        District.
      
Biospecimen description: 
      Blood sample for DNA examination
    
Keywords: Arteriosclerosis; Vascular function; Vascular disease early detection system