CBD, Immune Function, and Neural Health
Condition: Healthy
Study type: Interventional

Summary: 
      Chronic inflammation, which is defined as a persistent, low-grade inflammatory response
      within the body, is associated with many of the negative health conditions which are
      prevalent in our society today. It is most well-known for its role in the progression of
      diseases including obesity, metabolic syndrome, cancer, cardiovascular disease, and diabetes.
      Chronic inflammation is also linked to many of the underlying factors associated with disease
      development including perturbations in sleep, and mental health status such as depression,
      anxiety, fatigue, and quality of life. Natural killer cells, commonly referred to as NK
      cells, are a subset of white blood cells that play an important role in the coordination of
      inflammation in the body.

      Although many interventions aimed at controlling chronic inflammation and enhancing NK cell
      number and activity have been explored, relatively few have been administered without
      significant barriers. Cannabidiol (CBD), a non-psychoactive hemp derivative, is a potential,
      attractive therapeutic target. However, there is very little information in humans that
      addresses the potential of CBD to improve your health and immune function.

      The overall goal of this study is to explore the effects of 8-weeks of CBD supplementation on
      mental and physical health, sleep measures, and NK cell number and cytotoxic function.
      Specific Aim 1. Explore the effect of 8-weeks of CBD administration on sleep measures as well
      as measures of mental and physical health in conjunction with measurements of NK cell number
      and function.
    

Detailed description: 
      In this double-blind investigation, participants will undergo 8 total visits separated by an
      8-week intervention period. One week prior to the intervention period, participants will
      complete a blood draw, body composition analysis, aerobic and anaerobic fitness analysis,
      maximal strength testing, and physical activity and sleep quantity and quality analyses.
      These tests will be completed again following the 8-week intervention period. Following the
      first 4 visits, participants will be randomly assigned 1 of 2 groups: CBD (50mg/day) or
      calorie matched placebo. Participants will then complete the 8-week intervention period.
      Additionally, during week 4 of the 8-week intervention period (intervention midpoint),
      participants will complete a blood draw, one full week of physical activity and sleep
      actigraphy, surveys on mental health and wellbeing, and prevalence of sickness and illness
    

Intervention name(s): Cannabidiol (CBD)
Intervention type(s): Dietary Supplement
Intervention description(s): This group will receive an oral dose of CBD (Six Degrees Wellness).
Intervention MeSH terms: Cannabidiol
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Study participants will be randomly assigned to either a CBD group or a placebo group and followed throughout the 8 week intervention period.
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: CBD