Effect of PeakATP on Mood, Reaction Time and Cognition
Condition: Cognitive Change; Mood
Study type: Interventional

Summary: 
      Oral ATP disodium (adenosine 5'- triphosphate disodium) is a commercially available product
      available alone and as a constituent in a number of sports supplements that is purported to
      maintain ATP levels and improve performance during high-intensity exercise. Acute deficits in
      cognitive performance have also been reported in both young adults and children following
      high-intensity exercise; however, the effects of supplemental ATP on cognitive performance
      has not been studied.

      Goals:

        1. To investigate the effect of ATP supplementation versus. placebo on mood, reaction time
           and cognitive performance before and after an acute bout of fatiguing exercise.

        2. To investigate the effect of ATP supplementation versus. placebo on anaerobic
           performance.
    

Detailed description: 
      Oral ATP disodium (adenosine 5'- triphosphate disodium) is a commercially available product
      available alone and as a constituent in a number of sports supplements that is purported to
      maintain ATP levels during high-intensity exercise. Initial studies providing oral enteric
      coated ATP disodium displayed no apparent efficacy toward enhancing ATP levels, and
      subsequent research questioned the bioavailability of enteric coated ATP following oral
      administration (1,2). However, a recent study demonstrated that ingestion of 400mg uncoated
      ATP disodium for 15 days prevented decreases in ATP, adenosine diphosphate (ADP), and
      adenosine monophosphate (AMP) in the bloodstream for up to 30 minutes following
      high-intensity exercise when compared to placebo (3). Consistent with this, when oral ATP was
      administered in the form of non-coated ATP disodium, beneficial effects including reduced
      fatigue (3), improved strength, power, and body composition (5), and enhanced recovery (6)
      were observed.

      Acute deficits in cognitive performance have also been reported in both young adults (6) and
      children (7) following high-intensity exercise. Cerebral activity is coupled to ATP
      metabolism, where energy flux is tightly correlated with energy demand (8). Thus, inadequate
      availability of metabolic resources may lead to acute or long-term cognitive impairments (9)
      and correspondingly, interventions that sustain ATP levels may have application for
      attenuating cognitive dysfunction in the face of an acute stressor that challenges brain
      energy metabolism. Notwithstanding, no study to date has examined the effect of uncoated ATP
      disodium supplementation on cognitive performance following high-intensity exercise.

      Goals:

        1. To investigate the the effects of uncoated ATP disodium (PeakATP) on mood (POMS -
           Profile of mood states questionnaire), psychological stress and cognition (ANAM -
           Automated Neuropsychological Assessment Metric), reaction time (RT - Dynavision D2
           visuomotor tests), and multiple object tracking (MOT - Neurotracker)

        2. To examine the effects of uncoated ATP disodium (PeakATP) on end power (mean power
           during last 30 seconds of 3-minute test), anaerobic working capacity (work above end
           power), peak power, mean power, time to peak power, fatigue slope (W/sec), rate of
           fatigue (%), and total work (joules) during a 3-minute all-out cycle ergometer test.

      Method:

      Randomized, double-blind, placebo controlled cross-over trial comparing the effect of
      supplementation with Peak ATP versus placebo on mood, reaction time and cognitive
      performance.

      Supplementation will occur over a period of 14 days prior to completion of two separate
      experimental trials (randomly assigned), with a 14-day washout period in between. An acute
      dose will also be given during each experimental trial. POMS, RT, MOT and ANAM will be
      assessed pre- (0) immediately post- (IP) and 60-minutes (60P) post-completion of a 3-minute
      all-out cycle ergometer test. Anaerobic performance during the 3-minute test will be
      assessed.
    

Intervention name(s): PeakATP; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Powder - 400mg Peak ATP, maltodextrin, silica-colloidal anhydrous, citric acid anhydrous, sucralose, guar gum; Powder - maltodextrin, silica-colloidal anhydrous, citric acid anhydrous, sucralose, guar gum
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Other
Keywords: Adenosine Triphosphate