bioihbjkbjnl/mcl2 huggingface dataset:
Immediate Effect of Dynamic Stretching With and Without Floss Band on Flexibility of Hamstrings in Futsal Players
Condition: Sports Physical Therapy
Study type: Interventional

Summary: 
      To compare the immediate effect of dynamic stretching with and without floss band on the
      hamstring flexibility in futsal players.
    

Detailed description: 
      Futsal is a soccer-like indoor sport that has been gaining popularity worldwide.To increase
      the flexibility and ROM of involved muscle group a new method has been introduced named
      Flossing of tissue by using a floss band.

      This research study will be helpful to enable therapists to broaden their treatment plans or
      choose better treatment tools for improving hamstrings flexibility in futsal players. Thus,
      this study has been designed with the purpose to examine the effect of dynamic stretching
      with and without floss band on the flexibility of the hamstring.
    

Intervention name(s): Dynamic Stretching with Floss Band; Dynamic Stretching without Floss Band
Intervention type(s): Other; Other
Intervention description(s): Floss band involves wrapping a band made of natural rubber around the targeted joint or muscle for 1-3 minutes through active movement. The mechanism behind flossing is thought to have a "three-fold effect", compression may stimulate the mechanoreceptors of the underlying fascia layer which causes the hyperemia of the targeted tissue, and leads to increased blood flow.
This intervention was applied in addition to dynamic stretching which involved 3 types of dynamic stretches. These stretches were applied through multidirectional (anteromedial, anterior, and anterolateral) leg swings specifically for the Hamstring muscle. It was performed in 3 sets of 15 repetitions with 30 seconds of rest between each exercise.; In this group, only dynamic stretching was applied which involved 3 types of dynamic stretches. These stretches were applied through multidirectional (anteromedial, anterior, and anterolateral) leg swings specifically for the Hamstring muscle. It was performed in 3 sets of 15 repetitions with 30 seconds of rest between each exercise.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Concurrent Parallel Randomized Controlled Trial
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Dynamic Stretching; Flexibility; Flossing; Hamstring Muscles; Soccer; Sports Injuries
Exploratory Study Assessing Synchronisation of Egg Sacs With Degarelix
Condition: Infertility, Female
MeSH terms: Infertility; Infertility, Female
Study type: Interventional
Phase: Phase 2

Summary: 
      The main purpose of this clinical research study is to investigate if degarelix can
      synchronise the growth of the egg sacs in the ovaries and if degarelix has any effect on the
      lining of the womb.
    

Detailed description: 
      For the primary end-point (data collected on Stimulation Day 1), the study will compare
      degarelix 2.5 mg administered in the mid-luteal phase to placebo administered in the
      mid-luteal phase.

      After Stimulation Day 1 the placebo group will be split into two groups: a degarelix 2.5 mg
      follicular group and a ganirelix 0.25 mg group.
    

Intervention name(s): Degarelix mid-luteal, 2.5 mg; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Degarelix 2.5 mg will be injected subcutaneously (SC) 7 days after luteinizing hormone (LH) peak and on Stimulation Day 6. Placebo will be injected SC on Stimulation Day 1.; Placebo will be injected subcutaneously (SC) 7 days after luteinizing hormone (LH) peak. Degarelix 2.5 mg will be injected SC on Stimulation Day 1 and Stimulation Day 6.
or Placebo will be injected SC 7 days after LH peak and on Stimulation Day 1. Ganirelix 0.25 mg will be injected SC daily from Stimulation Day 6 until the last stimulation day.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Prevention
Keywords: Assisted Reproductive Technology (ART); oocyte donors undergoing controlled ovarian hyperstimulation for assisted reproductive technologies
Comparing Gabapentin and Amitriptyline for the Treatment of Neuropathic Pain in Children and Adolescents
Condition: Pain
MeSH terms: Neuralgia
Study type: Interventional
Phase: Phase 3

Summary: 
      The objective of the study is to compare the efficacy of gabapentin and amitriptyline for
      treating neuropathic pain in children in a randomized controlled trial.
    

Detailed description: 
      Clinical experience and case reports suggest that both amitriptyline and gabapentin are
      effective treatments for neuropathic pain in children; however we do not know which drug is
      more effective for specific pain conditions or for specific children. This study will be the
      first prospective, randomized double-blind controlled trial directly comparing gabapentin and
      amitriptyline for the treatment of neuropathic pain in a paediatric population. We will also
      study the time course for pain reduction and evaluate changes in children's physical
      function, mood, and sleep. This information is needed to determine which drug is better for
      which children and which pain conditions.
    

Intervention name(s): Gabapentin; Amitriptyline
Intervention type(s): Drug; Drug
Intervention description(s): Gabapentin will be prescribed at 900mg/d (300mg tid). A dose escalation schedule will be followed: one pill taken at night (~2000h) for the first 3 days, one pill at night and one pill in the morning (~0800h) for the second 3 days and finally, one pill at night, one in the morning and one mid-afternoon (~1400h) for the reminder of the trial.; Amitriptyline will be prescribed at a dose of 10mg (qhs). A dose escalation schedule will be followed: one pill taken at night (~2000h) for the first 3 days, one pill at night and one pill in the morning (~0800h) for the second 3 days and finally, one pill at night, one in the morning and one mid-afternoon (~1400h) for the reminder of the trial.
Intervention MeSH terms: Gabapentin; Amitriptyline
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Pain; Analgesia; Gabapentin; Amitriptyline; Pediatrics
Applicability of Video Games and Vibrational Therapy in Reducing Pain Secondary to Breast Cancer
Condition: Pain
MeSH terms: Breast Neoplasms
Study type: Interventional

Summary: 
      To evaluate the influence of virtual reality and vibrational therapy in reducing pain
      intensity secondary to breast cancer before and after application of treatment protocols,
      through biomedical instrumentation.
    

Detailed description: 
      After physiotherapy assessment individuals will be randomly divided into three groups: Group
      Virtual Reality - Cinesioterapia (G1), Group Vibration Therapy - Cinesioterapia (G2) and
      Control Group (G3), which will be submitted to the respective treatment protocols. Group
      Virtual Reality Cinesioterapia (G1) participate in this group 20 women will be treated
      through the games Xbox 360 ®, attributed to this, customized applications using virtual and
      augmented reality to be developed. Vibration Therapy Group - Cinesioterapia (G2) - will
      participate in this group 20 women who will undergo 15 minutes of continuous vibration
      through the blanket vibrating members higher, with frequency 40 Hz, 3 function and intensity
      tolerable, keeping the limb supported and elevated to 120 º. At the end held muscle
      stretching exercises, dissociation of shoulder girdle and upper limb exercises assets.
      Control group (G3) - participate in this group 20 women who are treated with conventional
      cinesioterapia through muscle stretching exercises for flexors, extensors, adductors and
      abductors shoulder for 20 seconds each; dissociation girdle; financial assets and Active
      assisted for groups flexors, extensors, abductors and adductors of the upper limbs, which
      will be performed three sets of 10 repetitions for each exercise. Implementation of treatment
      protocols for the groups G1, G2 and G3 will run for two weeks, being Monday through Friday
      feira.totalizando 10 consecutive treatment sessions lasting 30 minutes each session. You will
      be prompted to patients groups G1, G2 and G3 to respond individually and without any aid the
      visual numeric scale of pain, 10 minutes pre-therapy, 15 minutes after the start and 10
      minutes after the end of therapy. Patients will undergo the assessment of pain,
      electromyographic activity of muscles, muscle strength, range of motion analysis and
      perimetry in the first day of treatment, and after completing all the sessions patients were
      reassessed.
    

Intervention name(s): virtual reality
Intervention type(s): Other
Intervention description(s): customized applications using virtual and augmented reality to be developed.
Allocation: Non-Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Breast cancer; vibratory therapy; virtual reality
Reliability of the Smartphone Inclinometer App and Flexicurve
Condition: Disorder; Kyphosis Deformity of Thoracic Spine
MeSH terms: Kyphosis
Study type: Interventional

Summary: 
      The presedent study evaluates intra-rater and inter-rater reliability of the Smartphone
      inclinometer app and the flexicurve, on the thoracic kyphosis
    

Detailed description: 
      Sixty subjects ranging from 17to 24 years of age were evaluated by two independent evaluators
      using the Flexicurve and the Smartphone inclinometer app to measure thoracic kyphosis
    

Intervention name(s): Realibility
Intervention type(s): Other
Intervention description(s): measurement of the thoracic kyphosis with flexicurve and Smartphone inclinometer app
Other intervention name(s): İntra rater and inter rater
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Histology and Ultrasound Pilot Study of HA Gels Adipose Tissue
Condition: Atrophy
MeSH terms: Atrophy
Study type: Interventional

Summary: 
      This study is a single-blind intra-individual comparative study to evaluate the short and
      medium term tissue response after the injection of 2 brands of hyaluronic acid gels (HA),
      designed for deep injection, that have been used for several years on a worldwide scale.
    

Detailed description: 
      The study will be disclosed to patients who present with an indication for either
      abdominoplasty or bilateral breast reduction with a Wise pattern skin excision (inverted T
      inframammary scar) Informed consent will be obtained from volunteers at their next
      consultation, during which the preoperative preparation is finalised and the surgery is
      booked.

      Participants will receive injections for the first time three weeks to four months before the
      operation and for the second time five to nine days before the operation, in tissue that will
      be removed during the surgery.

      In each session, through one single access point, a linear retrograde, subcutaneous injection
      will be performed with 0,5 ml of each of the studied hyaluronic acid gels, each in an
      opposite direction, each parallel to the skin surface.

      Both sessions will be monitored by ultrasound examination. After the injections, the 2 cm of
      injected area which is most remote from the entrance point of the cannula will be remodelled
      by finger pressure and tissue pinching, to simulate remodelling as commonly performed after
      filler injection.

      At the beginning of the operation, the injected subcutaneous fat will be removed with the
      overlying skin, to be sent for histologic examination.

      The objective of the histologic examination is to assess the tissue response at one week
      versus three weeks to four months after the injection, as well as to assess the spread of the
      products, with and without remodelling after injection.
    

Intervention name(s): Hyaluronic Acid filler; Hyaluronic Acid filler
Intervention type(s): Device; Device
Intervention description(s): Linear retrograde, subcutaneous injection of 0,5 ml of hyaluronic acid gel in one side of the abdomen or one breast, 3 weeks to 4 months before the surgery.; Linear retrograde, subcutaneous injection of 0,5 ml of hyaluronic acid gel in other side of the abdomen or other breast, 5 to 9 days before the surgery.
Intervention MeSH terms: Hyaluronic Acid
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: Hyaluronic Acid; histology; ultrasound; subcutaneous; adipose tissue
Study of Radiolabeled Danicopan in Healthy Male Participants
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This was an open-label study to evaluate the absorption, distribution, metabolism, and
      excretion of radioactivity in healthy male participants following a single 150-milligram (mg)
      oral dose of carbon-14 ([14C])-ACH-014447 ([14C])-danicopan) containing approximately 100
      microcuries (µCi) of [14C].
    


Intervention name(s): [14C]-Danicopan
Intervention type(s): Drug
Intervention description(s): Liquid-filled capsules.
Other intervention name(s): ALXN2040; ACH-014447; ACH-4471; ACH4471; 4471
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Danicopan; ACH-0144471; ALXN2040; Absorption; Distribution; Metabolism; Excretion; Total Radioactivity; ADME
Megestrol in Treating Patients Who Are Undergoing Radiation Therapy for Lung Cancer
Condition: Anorexia; Cachexia; Lung Cancer
MeSH terms: Lung Neoplasms; Wasting Syndrome; Anorexia; Cachexia
Study type: Interventional
Phase: Phase 3

Summary: 
      RATIONALE: Megestrol helps improve appetite. It is not yet known if megestrol is effective in
      limiting weight loss in patients who are undergoing radiation therapy.

      PURPOSE: Randomized phase III trial to determine the effectiveness of megestrol in limiting
      weight loss in patients who are undergoing radiation therapy for lung cancer.
    

Detailed description: 
      OBJECTIVES:

        -  Determine the effect of megestrol on weight in patients receiving radiotherapy for lung
           cancer.

        -  Determine the quality of life of patients treated with this drug.

      OUTLINE: This is a randomized, placebo-controlled, double-blind, multicenter study. Patients
      are stratified according to histology (non-small cell lung cancer vs small cell lung cancer),
      and type of treatment (radiotherapy vs radiotherapy and non-cisplatin-containing chemotherapy
      vs radiotherapy and cisplatin-containing chemotherapy). Patients are randomized to one of two
      treatment arms.

      All patients undergo thoracic radiotherapy beginning on week 1 and continuing for a total of
      5-7 weeks.

        -  Arm I: Patients receive oral megestrol once daily beginning within the first 3 days of
           radiotherapy and continuing until 12 weeks after the completion of radiotherapy.

        -  Arm II: Patients receive oral placebo once daily beginning within the first 3 days of
           radiotherapy and continuing until 12 weeks after the completion of radiotherapy.

      In both arms, quality of life is assessed at baseline, at the completion of radiotherapy, and
      at 4, 8, 12, 16, and 20 weeks after the completion of radiotherapy.

      Patients are followed at 4 and 8 weeks.

      PROJECTED ACCRUAL: A total of 98 patients (49 per treatment arm) will be accrued for this
      study.
    

Intervention name(s): megestrol acetate; radiation therapy
Intervention type(s): Drug; Radiation
Intervention MeSH terms: Megestrol; Megestrol Acetate
Primary purpose: Supportive Care
Keywords: stage I non-small cell lung cancer; stage II non-small cell lung cancer; limited stage small cell lung cancer; stage IIIA non-small cell lung cancer; stage IIIB non-small cell lung cancer; anorexia; cachexia
Canadian Ticagrelor Survey
Condition: Acute Coronary Syndrome
MeSH terms: Acute Coronary Syndrome
Study type: Observational

Summary: 
      This study is designed to evaluate the effectiveness of the current ticagrelor risk
      minimisation strategy in Canada through a prescriber knowledge and understanding (KAU) survey
      of selected important identified safety concerns (i.e., bleeding, dyspnea and drug
      interactions) and ASA dosage.
    

Detailed description: 
      Effectiveness of risk minimisation interventions for ticagrelor in Canada
    

Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        All physicians who have prescribed at least one dose of ticargrelor and complete the
        Knowledge and understanding survey
Vaccine Therapy in Preventing Flu in Children With Acute Lymphoblastic Leukemia
Condition: Infection; Leukemia
MeSH terms: Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Lymphoid
Study type: Interventional

Summary: 
      RATIONALE: Flu vaccine may help the body build an immune response and decrease the occurrence
      of flu in children who are receiving chemotherapy for acute lymphoblastic leukemia.

      PURPOSE: Clinical trial to study the effectiveness of vaccine therapy in preventing flu in
      children who have acute lymphoblastic leukemia.
    

Detailed description: 
      OBJECTIVES:

        -  Determine the immune response, in terms of the formation of protective antibody titers
           to influenza, in children with acute lymphoblastic leukemia treated with split-virus
           trivalent influenza vaccine.

        -  Correlate the formation of protective antibody titers following immunization with the
           absolute neutrophil counts and absolute lymphocyte counts in these patients at the time
           of vaccination.

      OUTLINE: This is a multicenter study. Patients are stratified according to current treatment
      for acute lymphoblastic leukemia (consolidation chemotherapy vs maintenance chemotherapy vs
      off therapy for the past 6 months).

      Patients receive split-virus trivalent influenza vaccine intramuscularly once or twice at 4
      weeks apart for 2 doses.

      Patients are followed at week 5. Patients receiving 2 doses of vaccine are also followed at
      week 9.

      PROJECTED ACCRUAL: A total of 175 patients (50 receiving consolidation therapy, 75 receiving
      maintenance therapy, and 50 off therapy) will be accrued for this study within 2 years.
    

Intervention name(s): trivalent influenza vaccine
Intervention type(s): Biological
Primary purpose: Supportive Care
Keywords: childhood acute lymphoblastic leukemia in remission; infection
A Study to Assess an ATX Inhibitor (IOA-289) in Healthy Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of Part 1 of this First-in-Human trial is to evaluate the safety and tolerability
      after single ascending oral doses of IOA-289 given to healthy male subjects, compared to
      placebo. After the oral dose administrations, the amount of IOA-289 present in serum will be
      determined for pharmacokinetic characterisation. Also the reduction of LPA in plasma will be
      determined as a pharmacodynamic biomarker.

      Part 2 is optional and its conduct will be dependent on the pharmacokinetic data generated in
      Part 1. Part 2 will be a randomized, crossover, open label, single oral dose administration
      of IOA-289 to healthy male subjects either in a fasted state, or after a high-fat meal.
    


Intervention name(s): Single ascending doses of IOA-289; Placebo single doses
Intervention type(s): Drug; Drug
Intervention description(s): Single dose, oral administration of liquid-filled capsules, with a starting dose of 30 mg; Single dose, oral administration of liquid-filled capsules, matching placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Study of RDEA806 in Hyperuricemic Subjects With Symptomatic Gout
Condition: Hyperuricemia
MeSH terms: Hyperuricemia
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine whether RDEA806 is effective in the treatment of
      hyperuricemia in gout patients.
    


Intervention name(s): RDEA806; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Uricosuric agent for the treatment of gout; Matching Placebo.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Food Advertisements, Satiety and Food Intake in Children
Condition: Obesity Prevention
MeSH terms: Obesity
Study type: Interventional

Summary: 
      We hypothesized that FA in a TV program watched during a meal, would block satiety responses
      to pre-meal energy consumption and delay satiation in OW/OB but not in NW boys and girls.
      Food intake was measured at 30 min following a glucose (1 g of glucose/kg body weight) or
      sweetened noncaloric beverage with or without the presence of food advertisements. Subjective
      appetite will be measured as well.
    


Intervention name(s): Glucose with water; non-caloric sweetener with water; TV program with non-food advertisements while feeding; TV program with food advertisements while feeding
Intervention type(s): Dietary Supplement; Dietary Supplement; Behavioral; Behavioral
Intervention description(s): Glucose (1.0 g•kg-1 body weight ) in 250 mL of water 30 min before meal; 0.15 g of the high-intensity sweetener, Splenda sucralose in 250 mL of water 30 min before meal; 30 minutes of TV program containing non-food ads during a meal; 30 minutes of TV program containing non-food ads during a meal
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Children; Food advertisement; Obesity; Television viewing; Food intake