Training Inhibition in Alcohol Use Disorder
Condition: Alcohol Use Disorder
MeSH terms: Alcoholism; Alcohol Drinking
Study type: Interventional

Summary: 
      More and more studies aim to improve neurocognitive functioning in alcohol use disorder, but
      very few studies have focused on training-inhibitory-control efficacy on alcohol intake. Our
      program relies on a comprehensive model of addiction considering inhibition deficit as the
      hallmark of addiction. Our program proposes inhibition training on a task which does not
      refer to alcohol, combined with a debriefing promoting transferability of the enhanced skill
      and psychoeducation. In this perspective of aiming to retrain deficits involved in addiction
      in itself and not only due to alcohol toxicity. We propose an add-on single-blinded
      randomized controlled trial, in alcohol use disorder, assessing the efficacy of a
      computerized cognitive training program targeting inhibition as compared to treatment as
      usual.
    

Detailed description: 
      Our hypothesis is that a computerized program aiming to retrain deficits involved in
      addiction in itself and not only due to alcohol toxicity i.e.inhibition training on tasks
      which do not refer to alcohol, combined with a debriefing promoting transferability of the
      enhanced skills, in addition to treatment as usual, is more effective than a control
      condition in addition to treatment as usual.

      The program is a computerized cognitive training targeting inhibitory control of motor
      response (Scientific Brain Training®). The tasks included in the program have been selected
      and modified to target inhibition processes. The tasks are "find your way", "Don't fall in
      the trap", "Under pressure", "gulf-stream", "catch the ladybird" and an additional task:
      "Color and word Stroop test".

      The program must be dispensed twice a week with at least in the week one session on site, the
      other either on site or at home via an application to download, during 6 weeks.

      The duration for one session is 45 minutes, including:

        -  30 minutes performing the selected modules with increasing level of difficulty
           corresponding to their personal improvement. The patient will be able to choose within
           the selected modules the ones they want to perform during one session.

        -  15 minutes of group (for onsite sessions) debriefing mediated by a neuropsychologist.
           The debriefing will follow a semi-structured framework including a focus on the emotion
           associated with the task completion and a focus on the transferability of the tasks in
           the patient real life.

      Control condition: A sensorial program with similar conditions (45 minutes sessions twice a
      week), but targeting visual acuity, considered as neutral in the addiction field.
    

Intervention name(s): Cognitive training; Control training
Intervention type(s): Other; Other
Intervention description(s): Computerized cognitive training targeting inhibitory control of motor response used during 45 minutes sessions twice a week for 6 weeks; Fictitious computerized training used during 45 minutes sessions twice a week for 6 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other