bioihbjkbjnl/mcl2 huggingface dataset:
Influence of Reduced Daily Step Count and Anabolic Interventions on Muscle Protein Metabolism in Older Persons
Condition: Older Adults; Muscle Protein Synthetic Response to Protein; Reduced Physical Activity
Study type: Interventional

Summary: 
      As the loss of muscle mass with aging is associated with a dysregulation of muscle protein
      synthesis (MPS) that is generally characterized by an 'anabolic resistance' to nutrients, the
      primary outcome of the trial is to investigate the effect of a mixed macronutrient beverage
      on post-prandial myofibrillar MPS. However, the 'anabolic resistance' of aging may be
      predominantly influenced by the contractile activity of skeletal muscle; for example, the
      investigators have demonstrated that 2 weeks of reduced habitual activity (i.e. daily step
      count) induces anabolic resistance in otherwise healthy older adults. In contrast, resistance
      exercise is well-known to enhance muscle mass and can increase the sensitivity of skeletal
      muscle to dietary amino acids. Therefore, all participants will undergo a 2-week reduced step
      count intervention combined with a unilateral leg resistance exercise protocol to induce an
      'unhealthy' or 'anabolically resistant' leg and a relatively 'healthy' or 'anabolically
      sensitive' leg, respectively; this within subject model will be utilized to investigate the
      effect of the mixed macronutrient beverage in both relatively 'healthy' and 'unhealthy' older
      muscle. The investigators will also measure changes in muscle mass, muscle function, and
      cardiovascular health of both legs before and after the 2-week intervention to determine the
      effect of reduced activity and the protective effect of minimal, low-intensity exercise on
      these outcomes.
    


Intervention name(s): step-reduction; step-reduction plus resistance exercise
Intervention type(s): Other; Other
Intervention description(s): reduce daily physical activity to less than 1500 steps per day; reduce physical activity to less than 1500 steps per day with thrice weekly low-load, high effort resistance exercise
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
A Clinical Study to Evaluate the Effect of Mobile Applications "My A:Care" and "Smart Coach" on the Lipid-lowering Treatment Adherence of Subjects With Dyslipidemia in Thailand
Condition: Dyslipidemia
MeSH terms: Dyslipidemias
Study type: Observational

Summary: 
      A prospective, randomized, open-label, clinical study to evaluate the effect of mobile
      applications "My A:Care" and "Smart Coach" on the lipid-lowering treatment adherence of
      subjects with dyslipidemia in Thailand
    

Detailed description: 
      This is a prospective, randomized, open-label, clinical study in subjects with dyslipidemia
      and suboptimal adherence to their current lipid-lowering therapy in Thailand. Suboptimal
      adherence is defined as having <22 points score on the Part 1 of MARS-5VA questionnaire. This
      questionnaire comprises 2 parts, Medication Adherence Report Scale (MARS-5) as Part 1 and two
      Visual Analogue Scales (VAS) as Part 2. The complete MARS-5VA questionnaire (Part 1 and 2)
      will be used to evaluate subject adherence to lipid-lowering therapy in the study. The Part 1
      of MARS-5VA will also be used to confirm subject's eligibility at screening. Subjects who are
      continuing the stable lipid-lowering therapy for at least 1 month are being considered for
      this study. Subjects will be randomized to different types of behavior interventions using
      mobile applications that will be used in addition to their current standard of care (SOC)
      lipid-lowering therapy.
    

Intervention name(s): My A:care; Smart Coach
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Mobile application with Motivational messages; Mobile application with Motivational messages
Observational model: Other
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        This is a prospective, randomized, open-label, clinical study in subjects with dyslipidemia
        and suboptimal adherence to their current lipid-lowering therapy in Thailand.
A Randomized Controlled Trial to Test the Effect of a Smartphone Quit Smoking Intervention on Young Adult Smokers
Condition: Cigarette Smoking
Study type: Interventional

Summary: 
      The primary aim of this study will be to determine the effectiveness of a smartphone
      delivered app for young adult smokers on quitting smoking.
    

Detailed description: 
      The principle study purpose of the randomized controlled trial is to determine the
      effectiveness of a smartphone delivered app for young adult smokers on smoking cessation at
      six months using a randomized controlled trial. Secondary aims of this study include
      examining: 1) proximal outcome measures of cessation behaviour; 2) satisfaction, extent of
      app use and use of NRT and other cessation services; 3) mediators of cessation outcomes
      between conditions; and 4) the incremental cost-effectiveness.
    

Intervention name(s): Crush the Crave Application; On the Road to Quitting - Self Help
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Crush the Crave (CTC) allows users to customize a quit plan by choosing a quit date and then deciding whether to quit now or cut down the number of cigarettes they smoke every week up to the quit date. CTC reminds users of money saved and health improvements. Based on contingency reinforcement, rewards are provided, which smokers can then choose to share with their social network via Facebook. Supportive text messages tailored to their specific quit plan and where they are in the quitting experience are provided. CTC allows tracking of daily smoking habits and cravings as well as craving triggers or psychosocial determinants by recording when, where and why smoking occurred. Online distractions to help smokers deal with cravings are provided.; The control group will receive an evidence-based self-help guide known as "On the Road to Quitting" that has been developed by Health Canada for young adult smokers. Participants will be able to both view the self-help guide via the internet and will receive a printed version of the guide.
Other intervention name(s): Android; iPhone; Mobile phone; Behavior change; Quit smoking; Social media; Facebook
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Population Health; Smoking cessation; Young adults; Cancer prevention; Tobacco control strategies; Behaviour modification; Social Media; Smartphone technology
Altered Faecal Microbiome and Metabolome in CT1D, AT1D and T2D
Condition: Type 1 Diabetes Mellitus Maturity Onset
MeSH terms: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2
Study type: Observational

Summary: 
      To elucidate the characteristics of global gut microbiota and fecal/serum metabolites in
      patients with childhood-onset type 1 diabetes, adult-onset type 1 diabetes or type 2
      diabetes.
    

Detailed description: 
      Type 1 diabetes is caused by autoimmune destruction of pancreatic beta cells, leading to
      severe insulin deficiency and requiring insulin therapy. It is typically considered a disease
      of childhood and adolescence, but recent epidemiological data have shown that over half of
      all new-onset type 1 diabetes cases occur in adults worldwide. There are genetic, immune and
      metabolic differences between adult- and childhood-onset type 1 diabetes, revealing the
      underlying molecular basis of type 1 diabetes onset at diverse ages may differ. Accurate
      diagnosis is of great importance because the best treatment for different types of diabetes
      is divergent. Misdiagnosing type 2 diabetes as type 1 diabetes can lead to unnecessary
      initial insulin therapy, resulting in higher costs and more side effects. Thus, it is
      critical to identify the molecular basis and new diagnostic biomarkers for adult-onset type 1
      diabetes.

      Nonetheless, environmental exposures, in particular the immense intestinal microbiota and its
      derivatives, have been widely investigated. Indeed, patients with childhood-onset type 1
      diabetes or type 2 diabetes exhibit compositional alterations in gut microbiota. However, gut
      microbiota in adult-onset type 1 diabetes has not been elucidated, and little is known about
      the shared and distinct microbial characteristics in adult-onset type 1 diabetes versus
      childhood-onset type 1 diabetes or type 2 diabetes.

      Thus, this study is a cross-sectional study. 4 groups of subjects were recruited for
      metagenome and metabolome analysis, including healthy controls and patients with
      childhood-onset type 1 diabetes, adult-onset type 1 diabetes or type 2 diabetes. All subjects
      recruited meet the inclusion or exclusion criteria and written informed consent was obtained
      from each participant at enrollment.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Patients with childhood-onset type 1 diabetes, adult-onset type 1 diabetes or type 2
        diabetes. Healthy conrols recruited at the Second Xiangya Hospital of Central South
        University in Changsha.
      
Biospecimen description: 
      Feces，serum
    
Keywords: adult-onset type 1 diabetes; microbiota; metabolomics
Xbox Kinect, Sleep Quality, Anxiety and Functional Capacity in Older Adults
Condition: Sleep; Anxiety; Aging; Exercise
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      The present study aims to examine the effects of Xbox Kinect exercise training program on the
      sleep quality, anxiety and functional capacity in older adults. Older adults were randomized
      into two groups. The XBOX group performed exercise with Xbox Kinect during 60 min, three
      times/week for 6 weeks. The CONTROL group did not exercise. Pittsburgh Sleep Quality Index
      was used to evaluate sleep quality, anxiety symptoms by the State-Trait Anxiety Inventory,
      and the functional capacity was analyzed using following tests: Chair Stand Test, 8-Foot Up
      and Go Test, and 6-min Walk Test.
    


Intervention name(s): Exercise in the XBOX kinect
Intervention type(s): Behavioral
Intervention description(s): The XBOX group performed exercise for 60 min, three times/week, for 6 weeks, using the Xbox Kinect game "Your Shape Fitness evolved". This game was chosen because it simulates an environment with a variety of physical activities, in which the majority can be practiced by older adults. The activities were carried out individually. The game activities selected for the physical activity sessions were: 1) Zen-Develop it (stretching, balance and flexibility activities, similar to Yoga); 2) Pump it (to fill balls until they burst); 3) Wall Breaker (to break blocks, similar to boxing); 4) Kick it (soccer activity); 5) Hurricane (to lift the balls off the floor and not let them fall); 6) Stack in Up (balance activity).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Antiretroviral Regime for Viral Eradication in Newborns
Condition: HIV/AIDS and Infections
MeSH terms: Acquired Immunodeficiency Syndrome; HIV Infections
Study type: Interventional
Phase: Phase 4

Summary: 
      This is a multi-center, randomized, controlled, open clinical trial. The trial will be
      carried out in five provinces in China. Pregnant women with HIV infection and at high risk of
      mother-to-child transmission of HIV will be identified. Their newborn babies who are at high
      risk HIV infection will be recruited and randomized into intervention and control groups.
      Children in intervention groups will receive ART and intensive HIV testing after birth.
      Children in control group will receive routine prevention of mother-to-child transmission
      services. All the included children will be followed up and their development and infection
      status will be recorded and compared.
    


Intervention name(s): Zidovudine; Nevirapine; Lamivudine; Lopinavir/ritonavir
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Dose will be adjusted according to the child's weight.; Dose will be adjusted according to the child's weight.; Dose will be adjusted according to the child's weight.; Dose will be adjusted according to the child's weight.
Other intervention name(s): AZT; NVP; 3TC; LPV/r
Intervention MeSH terms: Ritonavir; Lopinavir; Lamivudine; Zidovudine; Nevirapine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: HIV; antiretroviral treatment; child; testing
Drug-Eluting Balloon in Arteriovenous Graft
Condition: Kidney Failure, Chronic; Angioplasty; Dialysis
MeSH terms: Renal Insufficiency; Kidney Failure, Chronic
Study type: Interventional

Summary: 
      The investigators' study aims is to evaluate the safety and efficacy of percutaneous
      transluminal angioplasty (PTA) with paclitaxel-coated balloon (PCB) at venous anastomotic
      stenosis of arteriovenous graft (AVG) in patients with hemodialysis
    


Intervention name(s): paclitaxel-coated balloon, IN. PACT(Invatec-Medtronic, Brescia, Italy); Plain Balloon
Intervention type(s): Device; Device
Intervention description(s): Arteriovenous graft (AVG) dysfunction or acute thrombosis is mainly caused by neointimal hyperplasia. Although endovascular intervention, such as percutaneous transluminal angioplasty (PTA), catheter-based directed thrombolysis with urokinase, mechanical thrombectomy with percutaneous thrombolytic device or even if graft stenting, can salvage the hemodialysis access, the long-term primary and secondary patent rate don't improve due to repeated restenosis from neointimal hyperplasia. Drug eluting balloon is used in reducing neointimal hypoplasia in patients with coronary in-stent restenosis and it's also effective in restenosis of peripheral arterial diseases. It's reasonable to hypothesize that PTA with PCB at venous anastomotic stenosis of AVG could prolong the patency and reduce the acute thrombosis rate.; Traditional Plain Balloon was used to dilate the venous anastomotic stenosis of arteriovenous graft (AVG) as the usual intervention
Intervention MeSH terms: Paclitaxel
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Angioplasty; Drug Eluting Balloon; Arteriovenous Graft
A Study to Investigate the Effect of Different Particle Sizes on the Single-dose Pharmacokinetics of Rilpivirine After Intramuscular Injection of a Long-acting Nanosuspension in Healthy Participants
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The main purpose of this study is to characterize the single-dose pharmacokinetics (PK) of
      rilpivirine (RPV) after intramuscular (IM) injection of rilpivirine long-acting parenteral
      formulation (RPV LA) nanosuspensions with different particle size distribution (PSD), in
      healthy adult participants.
    

Detailed description: 
      This is a phase 1, open-label (all people know the identity of the intervention), randomized
      (study medication is assigned by chance), parallel-group, sequential study in healthy adult
      participants to characterize the single-dose pharmacokinetics (PK) of rilpivirine (RPV) after
      intramuscular (IM) injection of RPV LA nanosuspensions with different particle size
      distributions (PSD), in healthy adult participants. A total of 110 healthy adult participants
      will be enrolled in this study. The study will consist of 2 treatment sessions in a fixed
      sequential order: Session 1- all participants will receive a single oral dose of rilpivirine
      25 milligram (mg) as oral immediate release solution on Day 1; Session 2- the participants
      will be randomized in session 2 on Day 1 in a 1:1:1:1:1 ratio to Treatments A, B, C, D and E.
      Each treatment group will receive a single IM injection of RPV LA on Day 1 of session 2.
      Session 1 and 2 will be separated by a washout period of at least 14 days. The total study
      duration for each participant will be approximately 9.5 months. Safety will be monitored
      throughout the study.
    

Intervention name(s): Rilpivirine; Rilpivirine Long-acting Parenteral Formulation
Intervention type(s): Drug; Drug
Intervention description(s): Rilpivirine 25 mg immediate release oral solution.; RPV LA 600 mg extended-release suspension for IM injection.
Intervention MeSH terms: Rilpivirine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Whole-body Hyperthermia for Mild to Moderate Depressive Disorder
Condition: Depression, Unipolar
MeSH terms: Hyperthermia; Fever; Depression; Depressive Disorder
Study type: Interventional

Summary: 
      The primary aim of this study is to investigate the effectiveness of whole-body hyperthermia
      in comparison to wait list on depressive symptom severity in patients with mild to moderate
      depressive disorder currently not under psychotherapeutic or antidepressant drug treatment.

      Secondary aims included further quality of life outcomes, immunological parameters, and
      tolerability/safety of the hyperthermia.
    


Intervention name(s): Whole-body hyperthermia
Intervention type(s): Device
Intervention description(s): Whole-body hyperthermia will be applied two times during 4 weeks (week 0 and 2 after randomization). The hyperthermia will be applied using Heckel-HT3000 MPIIb.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Depression; Hyperthermia; Randomized Controlled Trial
Safety and Immunogenicity of MT-5625 in Healthy Adults, Toddlers and Infants
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      A study to investigate the safety and reactogenicity of MT-5625 independently in adults aged
      18-35 years, toddlers ages 12-24 months, and infants aged 6-10 weeks
    


Intervention name(s): MT-5625 low dose; MT-5625 middle dose; MT-5625 high dose; Rotarix; Placebo
Intervention type(s): Biological; Biological; Biological; Biological; Biological
Intervention description(s): Intramuscular injection; Intramuscular injection; Intramuscular injection; Oral administration; Intramuscular injection
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
A Drug Safety and Dose-exploratory Clinical Study of Azvudine Tablets in Patients Who Have Not Received Anti-HIV Treatment
Condition: AIDS
Study type: Interventional
Phase: Phase 2

Summary: 
      The primary objective of this trial was to evaluate the safety and preliminary evaluation of
      Azvudine tablets (FNC) in combination with reverse transcriptase inhibitors therapy in
      treatment-naive patients with HIV infection.; the secondary objective is to explore the
      effective dose of clinical use of Azvudine (FNC) tablets .
    

Detailed description: 
      Azvudine (FNC), a new class I drug with independent intellectual property rights, is a novel
      nucleoside reverse transcriptase inhibitor with good inhibitory activity against HIV-1 and
      obtained the National Medical Products Administration(NMPA) approved for clinical research.

      In this trial, 172 patients who had not received anti-HIV treatment were enrolled, including
      FNC4mg group, FNC3mg group, FNC2mg group, and 3TC control group, 43 cases, 5 research
      centers, and each research center was simultaneously engaged and competing. The enrolled
      subjects underwent 7 visits including baseline visits, and HIV -1RNA and CD4 cell counts were
      tested and statistically analyzed for each visit.
    

Intervention name(s): The subjects were randomized to the treatment group of 3TC or different doses of FNC. The background drugs were EFV and TDF.
Intervention type(s): Drug
Intervention description(s): The subjects were randomized to the treatment group of 3TC or different doses of FNC. The background drugs were EFV and TDF.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: a multicenter, randomized, double-blind, double-simulation, positive control trial.
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Keywords: HIV/AIDS
Myofascial Release and Sustained Stretching in Spastic CP Children
Condition: Cerebral Palsy
MeSH terms: Muscle Spasticity; Cerebral Palsy
Study type: Interventional

Summary: 
      The aim of this research was to find and compare the effects of Myofascial Release Technique
      and Passive Sustained Stretching on Hamstrings Flexibility in Children with Spastic Cerebral
      Palsy.
    

Detailed description: 
      Randomized Clinical Trials done at DHQ Sahiwal. 26 spastic CP children of age 6-12 years were
      taken by random sampling technique from DHQ Sahiwal. 13 were allocated to each group. Study
      duration was of 6 months. Sampling technique applied was non probability convenience sampling
      technique Group A received Passive Sustained Stretching along with conventional treatment.
      Whereas Group B received MFR along with conventional treatment. Both these groups received
      treatment for 6 weeks. The baseline and post treatment score of MAS, Goniometer (AKET to
      measure popliteal angle) and GMFCS -88 were evaluated. Data analysis was done by using the
      SPSS version 21.
    

Intervention name(s): Passive sustained stretching; Myofascial Release
Intervention type(s): Other; Other
Intervention description(s): The Group A received Passive Stretching Technique. Along with the Passive Stretching Technique, this group also received certain conventional treatments which included resistive exercises, gait training exercises, bridging and exercises in other functional positions were also undertaken by the included individuals.
All the exercises mentioned above were performed for 30 minutes and there was not any specific division of time for all these mentioned activities. The patients used to perform these conventional treatments and exercises on their motor control basis. The exercises were performed for 30 minutes and been done for 5 days in a week for consecutive 6 weeks.; The Group B received Myofascial Release Technique and along with conventional treatments. The Myofascial Release Technique for hamstrings was given to the patient in prone position. The technique was applied either by the crossed hands or thumbs. This total treatment was given for 30 minutes consecutively. After the technique the Myofascial structures were stretched and then were hold for straight 120 seconds so that the tissues get softened. The technique was given to patients with 6 repetitions and with a hold for 120 seconds. The treatment was continued for 5 days a week for straight 6 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Spastic cerebral palsy; Passive Sustained Stretching; Myofascial Release; MAS; Goniometer