bioihbjkbjnl/mcl2 huggingface dataset:
Effect of GIP After a Meal in Patients With Type 2 Diabetes
Condition: Type2 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      The aim of this study is to investigate the effects of antagonising GIP after a meal on
      plasma levels of glucagon. 10 participants are going through four experimental days each,
      where they ingest a meal and afterwards receive infusions of either GIP receptor antagonist,
      GLP-1, GIP receptor antagonist + GLP-1 or placebo (saline) in a randomised order. The primary
      endpoint of the study is plasma levels of glucagon, which we hypothesize will decrease with
      infusion of GIP receptor antagonist and/or with infusion of GLP-1.
    


Intervention name(s): GIP(3-30)NH2; Peripheral venous cannulation; GLP-1
Intervention type(s): Other; Other; Other
Intervention description(s): Peptide derived from the naturally occuring gut hormone GIP; Intravenous access for infusions; Peptide infusion
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System
Condition: Cirrhosis; Hepatic Encephalopathy
MeSH terms: Hepatic Encephalopathy; Brain Diseases
Study type: Observational

Summary: 
      The purpose of the current study is to look into the pathogenesis of a severe medical
      condition causing acute episodes on the central nervous system as seen in majority of
      patients with liver cirrhosis.
    


Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy, 6 patients
        with liver cirrhosis without an acute episode of hepatic encephalopathy, 6 healthy subjects
        age and sex matched
      
Keywords: Ammonia; Astrocytes; Citric acid cycle; Alpha ketoglutarate dehydrogenase
Anxiety, Depression and Eating Attitudes of Diabetes Mellitus Patients During COVID-19 Lockdown in Greece
Condition: Diabetes Mellitus; SARS-CoV-2
MeSH terms: Diabetes Mellitus; Depression
Study type: Observational

Summary: 
      The aim of this observational, cross-sectional study is to evaluate the impact of the second
      national COVID-19 lockdown in Greece, regarding the aspects of depression, anxiety and eating
      habits, in relation to the adjusted work and family conditions, among diabetes mellitus
      patients.
    

Detailed description: 
      The national Lockdown was an attempt by the Governments around the world to prevent the
      spreading of the SARS-CoV-2. This pandemic turned out to be a major public health challenge.
      In Greece two national lockdown were imposed in 2020, among other measures, in order to
      minimize the spread of the SARS-CoV-2. The national lockdown consists of the temporary
      closure of the sports arenas, theaters, cafeterias, restaurants, cinemas, archaeological
      sites, schools, churches universities and most of the businesses . The first national
      lockdown in Greece was imposed from March 23th to May 4th and the second one took place from
      November 6th until now. Such a lockdown that forces the majority of individuals to stay at
      home for a prolonged period of time, except the controlled movement of the individuals for
      some cases, could expectedly enough have quite an impact on the daily life of people with
      diabetes mellitus. Changes to dietary habits, limitation of physical activity, as well as the
      psychological aspects like those of depression and anxiety have been detected. The aim of
      this study is to evaluate the impact of the second national lockdown in Greece, regarding the
      aspects of depression, anxiety and eating habits, in relation to the adjusted work and family
      conditions, among diabetes mellitus patients.
    

Intervention name(s): DASS questionnaire; EAT-26 questionnaire
Intervention type(s): Other; Other
Intervention description(s): The DASS is a 42-item self report instrument designed to measure the three related negative emotional states of depression, anxiety and tension/stress; The Eating Attitudes Test (EAT-26), is a self-report 26-item questionnaire of symptoms and concerns characteristic of eating disorders.
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        The study population will be recruited from the outpatient diabetes clinic of General
        Hospital of Chania and the Diabetes Center of the1st Propaedeutic Department of Internal
        Medicine of AHEPA General University Hospital of Thessaloniki in Greece. All participants
        prior to completing the survey had to give their informed consent in order to continue.
        Participants were free to abandon the survey at any time without any sanctions.
      
Keywords: Diabetes Mellitus; Anxiety; Depression; Eating attitudes
Prospective Study of 3 Phone Assistance Strategies to Achieve a Continuous Cardiac Massage
Condition: Cardiac Arrest
MeSH terms: Heart Arrest
Study type: Interventional

Summary: 
      This study must evaluate the benefit of a continuous audio guidance on the effectiveness of
      MCE directed by a volunteer.

      The evaluation of the MCE for this study is based on both quantitative criteria (based on the
      recommendations ERC 2010)

        -  frequency

        -  depth of chest compressions.

      This study compares two methods of continuous audio guide (one arm with an audio continuous
      guidance method by the regulator and second arm with an audio continuous guidance method by
      the controller relayed by an audio) to a method of incentive MCE based on a unique set made
      by the regulator(control arm).
    


Intervention name(s): Therapeutic and preventive strategies; Therapeutic and preventive strategies; Therapeutic and preventive strategies
Intervention type(s): Other; Other; Other
Intervention description(s): Single set (control Arm); Controller; Audio
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: external cardiac massage, medical hotline,
Effect of Arginine Supplementation in the Metabolic Syndrome
Condition: Overweight; Hypertriglyceridemic Waist
MeSH terms: Overweight; Metabolic Syndrome; Hypertriglyceridemic Waist
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether oral supplementation with one form of
      arginine improves vascular endothelial function in healthy subjects with risk factors
      associated with the metabolic syndrome
    

Detailed description: 
      The study is a randomized crossover study including 32 subjects with risk factors associated
      with metabolic syndrome. In a cross-over design, each subject received oral arginine and
      placebo, in a randomized order, and were studied the day preceding the first day of
      administration of arginine (or placebo) and after 4 weeks of arginine (or placebo)
      supplementation. The two periods of supplementation were separated by a washout period of at
      least 4 weeks.

      The subject were studied in the morning (when before supplementation) and in a whole day
      (when after supplementation).

      The mornings cessions consisted of fasting blood draw and vascular explorations, including a
      measurement of endothelium-dependent brachial artery reactivity ("Flow mediated dilation"),
      directly coupled to a measurement of post-ischemic digital reactivity (with the Endo-PAT
      method), completed by a measurement of non-endothelium-dependent brachial artery reactivity.
      An analysis of the pulse wave geometry was also performed.

      The whole-day cession consisted of the same fasting vascular explorations. Blood tests were
      performed fasting and repeated 2, 4 and 6 h after ingestion of a high-fat meal (900 kcal).
      Measurements of Flow mediated dilation was repeated 4h and postischemic digital reactivity
      were repeated 2, 4 and 6 h after ingestion of the high fat meal.
    

Intervention name(s): One form of arginine; placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 3 capsules containing 0.5g of one form of L-arginine (1.5g) 3 times daily (4.5g per day) for 1 month; 3 capsules containing 0.5g cellulose (non active product) 3 times daily (4.5g per day) for 1 month
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Keywords: arginine; supplementation; metabolic syndrome; endothelial function
Clinical Performance of a Glass-ionomer Restorative System: A 6-year Evaluation
Condition: Dental Caries
MeSH terms: Dental Caries
Study type: Interventional

Summary: 
      The aim of this clinical trial was to compare the clinical performances of a glass ionomer
      restorative system with a micro hybrid resin based composite in class I and class II
      cavities. A total of 140 (80 class I and 60 class II) lesions in 59 patients were restored
      with a glass ionomer restorative system (Equia) or a micro hybrid composite(Gradia Direct).
      Restorations were evaluated at baseline and yearly during 6 years according to the
      modified-USPHS criteria. Data were analyzed with Cohcran's Q and McNemar's tests (p<0.05).
    

Detailed description: 
      Since the introduction of glass ionomers many modifications of these materials have been
      performed over the years. Compared to other permanent filling materials like resin-based
      composites, glass ionomers show several advantages, such as the ability to adhere to moist
      enamel and dentin and anti-cariogenic properties such as the long-term fluoride release. So,
      it was doubtful that glass ionomers represent a capable counterpart of amalgam or resin-based
      composites in posterior teeth.
    

Intervention name(s): EQUIA; Gradia Direct Posterior
Intervention type(s): Other; Other
Intervention description(s): Placing glass ionomer restorations, the dentin and enamel of cavities were conditioned with 20% polyacrylic acid for 20 seconds, washed, and briefly dried. Equia Fil was injected into the cavity. Isolation was maintained using cotton rolls and a saliva ejector. After the setting time of 2.5 minutes, the restoration was polished wet using high-speed fine diamonds. When the restoration was briefly dried, Equia Coat was applied and photocured for 20 seconds using a photo-curing light.; The enamel and dentin were conditioned with G-Bond adhesive using a microtip applicator, left undisturbed for five to 10 seconds, and then dried thoroughly for five seconds with oil-free air under air pressure, Gradia Direct Posterior resin was applied with the incremental technique (2 mm thick layers) and light-cured for 20 seconds. Finally, the restoration was shaped with finishing diamonds and silicon instruments.
Other intervention name(s): Glass ionomer restorative system; Micro hybrid composite
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: glass ionomer cement; composite resin
Hypercapnia: Cognitive Effects and Monitoring
Condition: Hypercapnia; Exercise; Nitrogen Narcosis; Diving; Immersion
MeSH terms: Stupor; Hypercapnia; Inert Gas Narcosis
Study type: Interventional

Summary: 
      The investigators will simulate the conditions of a working, helmeted diver by using
      exercising, "head out" immersed subjects to test the following hypotheses:

        1. An algorithm can be developed which predicts cognitive performance in immersed
           exercising divers, based on the exhaled carbon dioxide (PETCO2) and the diver's inspired
           partial pressures of oxygen and nitrogen (PIO2 and PIN2).

        2. PETCO2 using mass spectrometry is an accurate estimate of arterial carbon dioxide
           (PaCO2) at rest and during immersed exercise and can be used as a PaCO2 surrogate at
           levels exceeding 50 mmHg and depths up to 158 fsw (gas density 6.4 g/l, similar to 165
           fsw density of 6.8 g/l).
    


Intervention name(s): NO exercise at depth; exercise at depth
Intervention type(s): Other; Other
Intervention description(s): Subjects will NOT exercise while at depth; Subjects will exercise while at depth
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: diving; cognitive impairment; nitrogen narcosis; narcosis; end tidal carbon dioxide; arterial carbon dioxide; immersion
Simvastatin in Uveitis
Condition: Uveitis
MeSH terms: Uveitis
Study type: Interventional
Phase: Phase 2

Summary: 
      The study evaluates anti-inflammatory effects and safety of simvastatin in non-infectious
      uveitis.
    

Detailed description: 
      3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors (statins) have been shown to
      reduce local and systemic inflammation in animal models of various autoimmune disorders
      including uveitis. In this open-label, randomized study clinical efficacy and tolerability of
      simvastatin 40 mg/day for 8 weeks is evaluated.
    

Intervention name(s): Simvastatin 40mg
Intervention type(s): Drug
Other intervention name(s): simvastatin
Intervention MeSH terms: Simvastatin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effects of Massage Therapy and Facial PNF in Early Bell's Palsy
Condition: Bell Palsy
MeSH terms: Bell Palsy; Facial Paralysis
Study type: Interventional

Summary: 
      Effects of Massage therapy and Facial PNF in early Bell's palsy
    

Detailed description: 
      It is an interventional study in which investigator will give massage therapy to one group of
      patients and facial PNF techniques to other group to evaluate the efficacy of these
      intervention on bell's palsy pateints
    

Intervention name(s): Facial PNF technique; Massage therapy
Intervention type(s): Other; Other
Intervention description(s): Stimulation techniques used to facilitate the weak muscle groups; frictional massage to stimulate the weak muscle groups
Other intervention name(s): Proprioceptive Neuromuscular Facilitation; Passive massage
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized control trail
Masking: Single (Participant)
Primary purpose: Other
Blue Sky Study: Impact of Milk and Vitamin D for Child Growth and Health
Condition: Vitamin d Deficiency
MeSH terms: Vitamin D Deficiency
Study type: Interventional
Phase: Phase 2

Summary: 
      This intervention study will address the impact of vitamin D fortified milk and vitamin D
      supplements on the growth, levels of vitamin D, insulin-like growth factor 1, growth hormone,
      academic attention, respiratory infections, asthma, and flexural dermatitis (a proxy for
      eczema) of Mongolian children.
    


Intervention name(s): Mongolian milk without vitamin D; Mongolian milk with vitamin D; UHT milk; Milk Substitute; Seasonal D supplement; Daily D supplement
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): 710ml per day for 49 days; 710ml per day for 49 days. A total of 13,700 IU of vitamin D over the intervention period.; 710ml per day for 49 days. A total of 13,700 IU of vitamin D over the intervention period.; 710ml per day for 49 days. A total of 13,700 IU of vitamin D over the intervention period.; Deliver dosage of 13,700 IU vitamin D over 7 days; Deliver dosage of 13,700 IU vitamin D in vitamin capsules over 49 days.
Other intervention name(s): Guum milk; Guum milk; Gossner milk; Mead Johnson; Tish Con; Tish Con
Intervention MeSH terms: Vitamin D; Ergocalciferols; Cholecalciferol; Vitamins
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Prevention
Keywords: vitamin d; children; Mongolia
A Multi-Center, Parallel Design, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of 6 and 12 mg Proellex® (Telapristone Acetate) Administered Orally in the Treatment of Premenopausal Women With Confirmed Symptomatic Uterine Fibroids
Condition: Uterine Fibroids
MeSH terms: Leiomyoma; Myofibroma
Study type: Interventional
Phase: Phase 2

Summary: 
      The primary objective of this study is to determine the safety and efficacy of two oral doses
      of Proellex administered for up to 2 courses of treatment (18 weeks each), each separated by
      an Off-Drug Interval (ODI), to premenopausal women with symptomatic uterine fibroids.
    


Intervention name(s): Telapristone Acetate; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Telapristone acetate, orally, once daily for 18 weeks (Course 1) and repeated for an additional 18 weeks (Course 2) following the ODI.; Matching placebo, orally, once daily for 18 weeks (Course 1) and repeated for an additional 18 weeks (Course 2) following the ODI.
Other intervention name(s): Proellex®; sugar pill
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Effects of Botanical Microglia Modulators in Gulf War Illness
Condition: Gulf War Illness
Study type: Interventional

Summary: 
      The overall objective of this protocol is to test if Gulf War Illness (GWI) involves chronic
      inflammation that cannot be measured with typical techniques. The investigators will be
      observing the effects of nine different botanical compounds (supplements) that are known to
      suppress inflammation. If one of those supplements helps the symptoms of GWI, it will give
      the investigators information about what is wrong in people with GWI.
    

Detailed description: 
      There is still a poor understanding of the pain, fatigue, and other symptoms that affect
      approximately 250,000 veterans. The precise mechanism of Gulf War Illness (GWI) is not
      understood, and there is no targeted treatment for the condition. A current model for GWI
      points to the central nervous system, immune cells, called microglia that may be hyperactive
      in patients with GWI. Discovering effective treatments for this disorder is a top priority of
      GWI research.

      Given the investigator's preliminary data, it is suspected that GWI is a form of low-level
      neuroinflammation that involves hypersensitivity of receptors on microglia. In order to help
      test that hypothesis, the investigators will be administering supplements that have been
      shown in vitro or animal in vivo to suppress microglia function in a way that is
      anti-inflammatory and neuroprotective. If any of these agents suppress symptoms in GWI, it
      will give the investigators important information about the disease that may allow for
      creation of better diagnostic tools and treatments in future research studies. Observing the
      effects of the selected nine anti-inflammatory botanical compounds, in this clinical study,
      is a strong compliment to the ongoing mechanistic GWI research.
    

Intervention name(s): Boswellia Serrata; Curcumin; Epimedium; Fisetin; Luteolin; Nettle; Pycnogenol; Reishi Mushroom; Resveratrol; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Other intervention name(s): Indian frankincense; Curcumasorb; Turmeric extract; Meriva; Barrenwort; Bishop's Hat; Fairy Wings; Horny Goat Weed; Yin Yang Huo; Common Nettle; urtica dioica; Stinging Nettle; Maritime Pine Extract; Pine Bark Extract; Red Wine Extract
Intervention MeSH terms: Curcumin; Resveratrol; Pycnogenols; Turmeric extract
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
Keywords: Gulf War Syndrome; Chronic Multisymptom Illnesses; Medically Unexplained Illnesses
A Trial to Evaluate the Safety of Once Weekly Dosing of Somapacitan (NNC0195-0092) and Daily Norditropin® FlexPro® for 52 Weeks in Previously Human Growth Hormone Treated Japanese Adults With Growth Hormone Deficiency
Condition: Growth Hormone Disorder; Adult Growth Hormone Deficiency
MeSH terms: Dwarfism, Pituitary; Endocrine System Diseases
Study type: Interventional
Phase: Phase 3

Summary: 
      This trial is conducted in Asia. The aim of this trial is to evaluate the safety of once
      weekly dosing of somapacitan (NNC0195-0092) and daily Norditropin® FlexPro® for 52 weeks in
      previously human growth hormone treated Japanese adults with growth hormone deficiency.
    


Intervention name(s): somapacitan; Norditropin
Intervention type(s): Drug; Drug
Intervention description(s): Once weekly subcutaneous injections (s.c., under the skin); Daily subcutaneous injections (s.c., under the skin)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Influence of Sacubitril/Valsartan on Autonomic Cardiac Nervous System in Heart Failure Patients: an Exploratory Study
Condition: Heart Failure Patients
MeSH terms: Heart Failure
Study type: Interventional

Summary: 
      Sacubitril/valsartan is an angiotensin receptor neprilysin inhibitor with the ability to
      reduce myocardial hypertrophy, cardiac remodeling and cardiorenal fibrosis. The compound is
      also believed to have antiarrhythmic properties as it has been shown to significantly reduce
      ventricular arrhythmias in patients with implantable cardioverter defibrillators.

      Patients suffering from heart failure with reduced ejection fraction show impaired heart rate
      variability, knowing that in these patients such impairment is highly associated with an
      increased risk of sudden cardiac death.

      In its pivotal study, sacubitril/valsartan demonstrated a significant advantage over
      enalapril in terms of cardiovascular mortality and rehospitalization.

      Against this background, this study was designed to analyze the largely unknown
      electrophysiological effects of sacubitril/valsartan on the autonomic cardiac nervous system
      by determining heart rate variability.
    


Intervention name(s): sacubitril/ valsartan
Intervention type(s): Drug
Intervention description(s): Heart rate variability measurement is carried out by means of a 12-channel ECG for 30 minutes in supine position followed by 10 minutes in standing position. All parameters, including blood values and echocardiographic parameters are assessed before beginning of sacubitril/ valsartan therapy and 3 months after starting treatment
Intervention MeSH terms: Valsartan; Sacubitril and valsartan sodium hydrate drug combination
Intervention model: Single Group Assignment
Intervention model description: Heart rate variability measurement is carried out by means of a 12-channel ECG for 30 minutes in supine position followed by 10 minutes in standing position. All parameters, including blood values and echocardiographic parameters are assessed before beginning of sacubitril/ valsartan therapy and 3 months after starting treatment.
Masking: None (Open Label)
Primary purpose: Treatment