Evaluation Of Stress Response In Diabetic Hypertensive Patients
Condition: Diabetes; Hypertension
MeSH terms: Hypertension
Study type: Observational

Summary: 
      In this research, we aimed to examine salivary cortisol changes in the cognitive stress
      response of patients with Hypertension + Diabetes Mellitus (HT+DM) and Hypertension (HT) and
      to determine the differences between them.

      The research was conducted by solving an arithmetic task as a stress test in 62 patients with
      HT+DM and HT that are being treated in the outpatient clinic of Medical Pharmacology and
      Clinical Pharmacology Department at Istanbul University, Istanbul Medical Faculty Hospital.
    

Detailed description: 
      In this study, saliva samples were taken for cortisol measurement, and patients were
      instructed to place the cotton piece in the salivette® tubes directly into their mouths
      without touching it with anything, hold it for 30-60 seconds, and then insert it back into
      the tubes in the same way, four times total, once before arithmetic stress and three times
      after stress, on Tuesdays, Wednesdays, and Thursdays between the hours of 12:00-16:00.

      Salivary cortisol was measured using the electro-chemiluminescence immunoassay.
    

Intervention name(s): First arithmetic problem solving; Second arithmetic problem solving; Third arithmetic problem solving; Fourth arithmetic problem solving; Fifth arithmetic problem solving; Sixth arithmetic problem solving
Intervention type(s): Behavioral; Behavioral; Behavioral; Behavioral; Behavioral; Behavioral
Intervention description(s): In a quiet environment, a white paper in A4 format was placed in front of the patient on the table, and the patients were asked to subtract the number 3 from 2907 for 100 seconds.
The researcher was standing in front of the patient and asks to make corrections by giving a warning whenever the patient made a mistake in the calculation.; In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the first subtraction process, patients were asked to subtract 7 from 6828 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.; In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 13 from 9561 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.; In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 8 from 5113 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.; In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 14 from 8318 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.; In the same A4-sized white paper that was placed in front of each patient on a table, immediately after the previous subtraction process, patients were asked to subtract 17 from 9994 for another 100 seconds.
When the patient made a calculating error, the researcher stood in front of the patient and asked them to make corrections by issuing a warning.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The study population consisted of patients in the register of the pharmacology clinic of
        the faculty of medicine who have a diagnosis of hypertension and diabetes mellitus type 2.
      
Keywords: Diabetes mellitus; Hypertension; Cortisol; Stress; Aldosterone