Taurine Supplementation and Exercise on Irisin Levels in Obesity
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional

Summary: 
      Irisin is a myocin secreted by skeletal muscle in stimulus to physical exercise and has been
      described as a possible therapeutic tool in the fight against obesity by triggering a cascade
      of signaling that triggers the expression of genes responsible for the increase in energy
      expenditure and browning of adipose tissue white cells by activating thermogenesis promoter
      mitochondrial proteins. Although the science is engaged in the search for evidences about the
      actions of the irisin, the physical exercise involved and the improvement in the levels of
      obesity, many mechanisms are still unknown. Since taurine by means of irisin-like pathways
      also increases energy expenditure, it is believed that taurine supplementation associated
      with high intensity aerobic physical exercise can optimize the effects of irisin, increasing
      energy expenditure and improving body composition in obesity.
    

Detailed description: 
      Introduction: Irisin is a myocin secreted by skeletal muscle when stimulated by physical
      exercise that promotes increased thermogenesis (browning effect). Similarly, taurine is also
      associated with modulations of energy metabolism with promising actions in the control of
      metabolic disorders. Thus, it is believed that chronic taurine supplementation associated
      with physical training can optimize irisin concentrations after exercise.

      Objective: Evaluate the effects of taurine supplementation associated with interval aerobic
      training on plasma irisin concentrations, energy expenditure, body composition and physical
      fitness in obese women. Methods: Twenty-two women aged 25 to 45 years, sedentary, with grade
      I obesity (BMI ≥30-35 kg / m²) and without comorbidities will be recruited for the study. The
      subjects will be submited to a high intensity interval aerobic training for 8 weeks, being 3
      times by week, for 50 minutes, associated to the supplementation with 3g of taurine or
      placebo.

      Methods: Assessment of dietary intake, Resting Energy Expenditure (GER) by indirect
      calorimetry, body composition by deuterium oxide, anthropometric measurements, HPLC plasma
      analysis of taurine, multiplex irisin and physical fitness variables will be performed pre
      and post intervention. The results will be expressed as mean and standard deviation and the
      ANOVA test two way repeated measures mixed model will be applied, with post hoc Sidak, to
      verify differences and statistical interactions (p <0.05).
    

Intervention name(s): Taurine group and exercise and placebo group and exercise; Physical training with Deep Water Running
Intervention type(s): Dietary Supplement; Other
Intervention description(s): Both groups supplemented with taurine and / or placebo will perform physical training.; There will be a physical training for eight weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: double blind trial
Masking: Double (Participant, Investigator)
Primary purpose: Other
Keywords: Obesity; Exercise; Irisin; Taurine; Energy Expenditure