bioihbjkbjnl/mcl2 huggingface dataset:
The Influence of GVS on Mental Transformation
Condition: Focus of Study: Higher Cognition and the Vestibular System
Study type: Interventional

Summary: 
      Corroboratory behavioral evidence showed interaction effects between vestibular stimulation
      and egocentric transformation.

      The investigators here examine in healthy participants, whether there are shared brain
      mechanisms underlying galvanic vestibular stimulation, illusory self-motion and egocentric
      transformation, as well as their interaction.

      It is hypothesized that the GVS induced illusory self-motion dampens the ability to perform
      egocentric mental transformation.
    

Detailed description: 
      Theories of embodied mental rotation suggest overlapping processes between real body and
      egocentric mental transformations. Corroboratory behavioral evidence showed interaction
      effects between vestibular stimulation and egocentric transformation. Yet, no study so far
      has investigated which cortical areas are involved in vestibular processing and/or illusory
      self-motion and mental transformation tasks within the same participants. This however seems
      crucial, as important individual differences exist for both mental transformation abilities
      as well as in subjective perception of artificial vestibular stimulation.

      The primary objective is to reveal which brain area(s) are involved in the interaction of
      illusory self-motion (as induced by galvanic vestibular stimulation (GVS)) and egocentric
      mental transformation, as compared to no illusory self-motion or object-based mental
      transformation. It is hypothesized that the GVS induced illusory self-motion dampens the
      ability to perform egocentric mental transformation more than object-based mental
      transformation.

      As previous behavioral studies on such an interaction were always done in a sitting position,
      a secondary objective is to first replicate previous behavioral mental rotation studies that
      used GVS, in the Magnetic Resonance (MR) -scanner comparable setting. Moreover, as no brain
      imaging study so far has investigated subjective illusory motion experience induced by GVS,
      illusory self-motion will be measured and included in the statistical model to find specific
      brain regions modulating the illusory self-motion perception.
    

Intervention name(s): Galvanic Vestibular Stimulation
Intervention type(s): Device
Intervention description(s): The investigators aim to study the influence of Galvanic Vestibular Stimulation on the brain mechanisms underlying illusory self-motion and its influence on egocentric mental transformation. As a control condition sham stimulation will be applied by the same device within the same participants in different trials. Participants should not note the difference.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Transbronchial Needle Aspiration in the Diagnosis of Peripheral Pulmonary Malignancy
Condition: Pulmonary Nodule; Pulmonary Mass
MeSH terms: Multiple Pulmonary Nodules
Study type: Observational

Summary: 
      The main purposes of this study are to assess the performance characteristics of
      transbronchial needle aspiration (TBNA) in the diagnosis of peripheral pulmonary lesions, and
      to identify the predictor variables of a positive aspirate.
    

Detailed description: 
      In a recent systematic literature review (Rivera PM, Mehta AC; Chest 2007; 132: 1318-1488)
      TBNA showed the highest sensitivity in the diagnostic bronchoscopic approach to peripheral
      pulmonary lesions, as compared to the other available sampling techniques (transbronchial
      biopsy, brushing, washings). However, the Authors conclude that the data regarding TBNA in
      this setting deserve cautious interpretation because of the limited number of studies and the
      large differences in sample size). We designed the present study to assess the performance
      characteristics of TBNA, alone and in comparison with those of transbronchial biopsy, in the
      diagnosis of peripheral pulmonary lesions.
    

Intervention name(s): TBNA + transbronchial lung biopsy + bronchial washing
Intervention type(s): Procedure
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Adult patients with pulmonary nodule or mass referred for bronchoscopy to the Thoracic
        Endoscopy Unit of Maggiore Hospital (Bologna Italy)
      
Keywords: Lung cancer; Lung nodule; Transbronchial needle aspiration; Transbronchial lung biopsy; Bronchoscopy
A Bioequivalence Study of Bimekizumab Given as 1x2mL or 2x1mL Subcutaneous Injection Using an Autoinjector in Healthy Study Participants
Condition: Healthy Study Participants
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of the study is to compare the pharmacokinetics (PK), safety and tolerability of
      a single subcutaneous (sc) dose of bimekizumab (BKZ) when administered using
      bimekizumab-autoinjector (AI)-2mL presentation versus bimekizumab-AI-2x1mL presentation in
      healthy study participants.
    


Intervention name(s): bimekizumab
Intervention type(s): Drug
Intervention description(s): Study participants will receive a single dose of bimekizumab (BKZ) administered subcutaneously in the Treatment Period.
Other intervention name(s): BKZ; UCB4940
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: UCB4940; BKZ; bimekizumab; Bioequivalence; Auto-injector; Healthy study participants
Effects of OAGB and DJB-SG on 10-year and Lifetime Risks of MACE
Condition: Obesity
MeSH terms: Obesity
Study type: Observational

Summary: 
      Metabolic bariatric surgery (MBS) has demonstrated its efficacy in achieving sustainable
      weight loss and alleviating associated comorbidities. The primary objective of our
      investigation is to assess the long-term impact and sustainability of weight loss, the
      remission of T2D as well as risk prediction of cardiovascular events following MBS concerning
      one-anastomosis gastric bypass (OAGB) and duodenojejunal bypass with sleeve gastrectomy
      (DJB-SG).
    

Detailed description: 
      Metabolic bariatric surgery (MBS) offers enduring weight reduction and alleviation of
      obesity-related comorbidities, including dyslipidemia, type 2 diabetes (T2D), hypertension
      (HTN), and major adverse cardiovascular events (MACE). Long-term data on one anastomosis
      gastric bypass (OAGB) and duodenal-jejunal bypass with sleeve gastrectomy (DJB-SG) is
      lacking, necessitating this investigation. In this multicenter prospectively-collected
      retrospective observational study, patients with complete follow-up data at various intervals
      up to 3 years after surgery were included in the final analysis. The study's primary focus
      was to evaluate the long-term safety, efficacy, and durability of OAGB and DJB-SG in
      promoting weight loss and T2D remission. Additionally, changes in 10-year and lifetime risks
      of MACE before and 3-year after surgery were assessed using the Taiwan MACE risk prediction
      model and the China-PAR project model based on Taiwan national electronic health records and
      a large Chinese participant dataset, respectively.

      Hypothesis: This study contributes to providing valuable information in terms of the impacts
      of OAGB and DJB-SG on patients with obesity and associated diseases.
    

Intervention name(s): OAGB; DJB-SG
Intervention type(s): Procedure; Procedure
Intervention description(s): using OAGB procedure as metabolic bariatric surgery; using DJB-SG procedure as metabolic bariatric surgery
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Taiwanese adult patients, whose age are between 20 and 65 years old, with obesity and/or
        cormobidities and metabolic disorders, such as type 2 diabetes mellitus, hypertension,
        dyslipidemia, obstructive sleep apnea, etc.
      
Keywords: One-anastomosis gastric bypass; Duodenal-jejunal bypass with sleeve gastrectomy; Major adverse cardiovascular events; Type 2 diabetes mellitus; Obesity; Comorbidities
The Role of Resistance Exercise in Chronic Obstructive Pulmonary Disease Exacerbation
Condition: Chronic Obstructive Pulmonary Disease
MeSH terms: Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether resistance exercise are effective in
      combating the decline in muscle strength during an exacerbation of Chronic Obstructive
      Pulmonary Disease (COPD).
    

Detailed description: 
      Acute exacerbations are common in patients with COPD and cause specific signs and symptoms,
      such as increased dyspnea, productive cough with altered sputum, and fever. With disease
      progression, exacerbations are frequent and have a negative impact on health related quality
      of life and pulmonary function as well as increase mortality. More severe exacerbations
      require hospitalization resulting in enormous health expenditures, severely reducing daily
      life activities and declining peripheral muscle strength that can be only partially reversed
      after 3 months. Despite many features have been pointed out as responsible for the decrease
      in muscle strength during hospitalization, physical inactivity seems the most important.

      Resistance training is an interesting therapeutic option to prevent and/or reverse muscular
      dysfunction due to immobilised in healthy subjects and stable COPD patients because induces
      hypertrophy of type II fibers, increases muscle strength and exercise tolerance. In addition,
      provokes lower dyspnea perception during effort compared with other exercise training.
      Despite these benefits for stable COPD, the impact of a resistance exercise program during
      hospitalization remains poorly known.
    

Intervention name(s): Resistance training
Intervention type(s): Other
Intervention description(s): Resistance training group received training program for upper (shoulder flexion and abduction and biceps) and lower limbs (knee extension and flexion and hip flexion). Daily exercise for every muscle was performed with free weights at 80% of an maximal repetition test and a 4 minutes rest was allowed between each step.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: chronic obstructive pulmonary disease; exacerbation; resistance training; muscle force
NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain
Condition: Disease (or Disorder); Intervertebral Disc, With Myelopathy (Manifestation)
MeSH terms: Spinal Cord Diseases; Disease
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a multiple-dose, double-blind, double-dummy, active-control, parallel-group,
      multi-center, safety and efficacy study.
    


Intervention name(s): Buprenorphine Transdermal System; Buprenorphine Transdermal System
Intervention type(s): Drug; Drug
Intervention description(s): Titration period（21 days）:BTDS 5 mg or oral tramadol CR 100 mg bid, and will then be titrated, if necessary, a maximum of BTDS 20 mg or oral tramadol CR 200 mg bid will be given.
maintenance period(5 week):Patients will continue at a dosage level that provided acceptable pain control .; Titration period（21 days）:BTDS 5 mg or oral tramadol CR 100 mg bid, and will then be titrated, if necessary, a maximum of BTDS 20 mg or oral tramadol CR 200 mg bid will be given.
maintenance period(5 week):Patients will continue at a dosage level that provided acceptable pain control .
Intervention MeSH terms: Buprenorphine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Dapagliflozin in PRESERVED Ejection Fraction Heart Failure
Condition: Chronic Heart Failure With Preserved Systolic Function
MeSH terms: Heart Failure
Study type: Interventional
Phase: Phase 4

Summary: 
      The primary purpose of this study is to evaluate the impact of dapagliflozin, as compared
      with placebo, on heart failure, disease specific biomarkers, symptoms, health status and
      quality of life in patients with chronic heart failure with preserved systolic function.
    

Detailed description: 
      A 12-week randomized, double-blind, placebo-controlled trial to evaluate the effects of
      once-daily dapagliflozin 10 mg on heart failure disease-specific biomarkers (NTproBNP and
      BNP), symptoms, health status, and quality of life in patients with chronic heart failure
      with preserved systolic function. An imaging substudy will also be conducted to explore the
      effects of dapagliflozin vs. placebo on various echocardiographic parameters.
    

Intervention name(s): Dapagliflozin 10Mg Oral Tablet; Dapagliflozin matching placebo
Intervention type(s): Drug; Drug
Intervention description(s): Dapagliflozin 10Mg Oral Tablet; Dapagliflozin matching placebo
Other intervention name(s): Farxiga; Placebo Oral Tablet
Intervention MeSH terms: Dapagliflozin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: heart failure; dapagliflozin; SGLT-2 inhibitors
Prevalence of Atelectasis in Critical Trauma Patients
Condition: Pulmonary Atelectasis
MeSH terms: Pulmonary Atelectasis
Study type: Observational [Patient Registry]

Summary: 
      The purpose of this study is to identify the prevalence rate and risk factors for pulmonary
      complications in patients with critical trauma who intubated and mechanical ventilation.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        The critically traumatic patients who were admitted to the traumatic surgical intensive
        care unit at Khon Kaen Hospital (February 2016 to February 2017).
      
Keywords: trauma; atelectasis
Ultrasonography in Juvenile Idiopathic Arthritis
Condition: Juvenile Idiopathic Arthritis, Oligoarthritis; Polyarticular Juvenile Rheumatoid Arthritis; Systemic Juvenile Idiopathic Arthritis
MeSH terms: Arthritis; Arthritis, Juvenile
Study type: Observational

Summary: 
      The purpose of this study is to analyse the usability of ultrasonography together with
      biomarkers in the investigation of patients diagnosed with juvenile idiopathic arthritis. The
      investigators hypothesize that serum and urine markers of cartilage and bone synthesis and
      degradation, together with ultrasound measurements of joint cartilage thickness, are useful
      tools in the early evaluation of JIA patients, - as diagnostic, prognostic and monitoring
      methods.
    


Intervention name(s): Ultrasonography
Intervention type(s): Device
Intervention description(s): Scanning 5 joints bilaterally with an ultrasound scanner
Other intervention name(s): Hitachi EUB-7500
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Children diagnosed with Juvenile Idiopathic Arthritis, followed in dept of pediatric
        rheumatology, Aarhus University Hospital, Skejby
      
Biospecimen description: 
      Serum specimens taken for rutine markers of inflammation.
    
Keywords: Juvenile idiopathic arthritis; Ultrasonography; Cartilage; Cartilage biomarkers; Bone biomarkers
Effects of PECS 1 Block on Venous Cancer Port Catheter
Condition: Catheter; Pain (Indwelling Catheter)
Study type: Interventional

Summary: 
      In this study our aim is to investigate the effects of ultrasound (USG) guided pectoral block
      (PECS) type 1 in the administration of an implanted port-a-cath .
    

Detailed description: 
      Cancer is one of the most important reasons of mortality in the world. There are a lot of
      different types of treatments for cancer and so far chemotherapy is the most common one.
      However, chemotherapy damages the peripheral veins, so implanted subcutaneous port-a-caths
      are used as an alternative. Traditionally this implantation is adminstered with infiltrative
      anesthesia. Recently, USG is used in anesthesia practice world wide. Blanco R et all (1)
      defined PECS 1 block as an alternative to paravertebral block. PECS 1 block aims to
      anesthetize the medial and lateral pectoral nerves. In this study our aim is to investigate
      the effects of USG guided PECS 1 block in the administiration of an implanted port-a-cath .
    

Intervention name(s): Port-a-cath replacement
Intervention type(s): Procedure
Intervention description(s): Implantation of a subcutaneous venous port-a-cath
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The study will be a two-arm parallel assignment. One group will receive PECS 1 block and the other will receive infiltrative anesthesia.
Masking: Single (Participant)
Primary purpose: Treatment
SKOLKONTAKT - Social Skills Training in a School Setting
Condition: Autism Spectrum Disorder; Attention Deficit Hyperactivity Disorder; Anxiety; Depression
MeSH terms: Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder
Study type: Interventional

Summary: 
      The study investigates the behavioral effects of an adapted manual-based social skills
      training program (SKOLKONTAKT) for the mainstream education plan delivered by school
      personnel, with pupils (15-20 years) with social-communication needs; either formally
      diagnosed (i.e. autism spectrum disorders or ADHD) or teacher-reported subclinical
      difficulties. N=40 are recruited from a community school in the Stockholm area (Sweden).
    

Detailed description: 
      So far, research has failed to consider the effectiveness of social skills training in school
      settings, and has instead focused on clinical or laboratory settings. This approach presents
      an interesting paradox given that the primary goal of social skills training is to affect
      change in the child's behavior in everyday life including school. Research undertaken in
      authentic everyday environments is not only more likely to result in real world outcomes for
      children and adolescents with ASD and ADHD, but greater utility in guiding models of service
      delivery. The objective of the current line of research is to adapt and evaluate methods
      originally designed to support children and adolescents with ASD and ADHD in clinical
      settings ("KONTAKT"), to be feasible and effective in school settings, that can be conducted
      by school personnel, and are are applicable to children with autistic and inattentive,
      hyperactive-impulsive disorders, as well as other less defined special social needs
      ("SKOLKONTAKT").
    

Intervention name(s): SKOLKONTAKT; Social activity group
Intervention type(s): Behavioral; Behavioral
Intervention description(s): N=21 participants are offered manualized and structured group training SKOLKONTAKT. The intervention includes 12 weeks, 3 sessions (50 minutes) per week.; N=21 participants. The active comparison group includes 12 weeks, 3 sessions (50 minutes) per week. Sessions will include socially oriented activities such as board games, sports or baking as well as a recommended, general agenda.
Other intervention name(s): SKOLKONTAKT Social skills training; SKOLKONTAKT Social skills group training; SKOLKONTAKT School-based social skills training
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Social skills group training; School-based intervention; Evidenced-based intervention
Internet-delivered CBT for Adolescents With Obsessive-Compulsive Disorder - a Pilot Study
Condition: Obsessive-Compulsive Disorder
MeSH terms: Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Study type: Interventional

Summary: 
      The main goal of this trial is to study the feasibility and effectiveness of
      internet-delivered cognitive behavior therapy for adolescents with obsessive-compulsive
      disorder.
    


Intervention name(s): Internet-delivered Cognitive Behavior Therapy
Intervention type(s): Behavioral
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: cognitive behavior therapy; pediatric obsessive-compulsive disorder; internet-delivered cognitive behavior therapy
Effects of BMS-986256 at Steady State on the Single Dose Pharmacokinetics of Mycophenolate Mofetil
Condition: Healthy Participants
Study type: Interventional
Phase: Phase 1

Summary: 
      A Study to Investigate BMS-986256 at steady state and its effect on Mycophenolate Mofetil
      exposure in Healthy Male Participants
    


Intervention name(s): BMS-986256; Mycophenolate Mofetil
Intervention type(s): Drug; Drug
Intervention description(s): specified dose on specified days; specified dose on specified days
Intervention MeSH terms: Mycophenolic Acid
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Randomized Controlled Trial of Human Papillomavirus Testing in Primary Cervical Cancer Screening
Condition: Cervical Cancer; Cervical Intraepithelial Neoplasia
MeSH terms: Uterine Cervical Neoplasms; Uterine Cervical Dysplasia
Study type: Interventional

Summary: 
      Human papillomavirus (HPV)-based cervical screening is known to increase sensitivity for
      detection of high-grade cervical intraepithelial neoplasia (CIN). Randomized trials of
      longitudinal efficacy are required to assess whether these gains represent overdiagnosis or a
      protective effect.

      Methods: A total of 12527 women, aged 32-38, attending population-based invitational
      screening in Sweden were randomized 1:1 to HPV test and cytology (intervention arm) or
      cytology only (control arm). HPV-positive women were invited for a second HPV test at least
      one year later and women with type-specific persistent infections were then invited to
      colposcopy. A similar number of random double-blinded procedures are performed in the control
      arm. Women are followed with comprehensive registry-based follow-up. Primary outcome is the
      relative rates of CIN grade 2 or worse (CIN2/CIN3+) found in subsequent screening. Secondary
      outcomes are the relative rates of CIN2/CIN3+ found in the aseline screening and outcomes
      stratified by grade of CIN (CIN 2 or CIN3+).
    


Intervention name(s): Adding Human Papillomavirus testing to organised cervical screening
Intervention type(s): Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Screening
Keywords: screening; human papillomavirus