bioihbjkbjnl/mcl2 huggingface dataset:
The Relationship Between Different Doses of Propofol and the Occurrence of Dreams in Short Surgery Under General Anesthesia
Condition: Dreaming; General Anesthesia
Study type: Interventional

Summary: 
      Dreams are a remarkable experiment in psychology and neuroscience, conducted every night in
      every sleeping person. 74% of awakenings from REM sleep resulted in recall of a dream, as
      compared with only 9% of awakenings from NREM sleep. The association between dreaming and REM
      sleep was subsequently replicated by many other investigators; typically, around 80% of REM
      awakenings yield dreams. It became clear over time that there is a good deal of mental
      activity that occurs during NREM sleep. Typically, it is more thought like, fragmentary, and
      related to daily concerns than the vivid, hallucinatory, predominantly visual narratives that
      are most commonly reported from REM sleep. But even this distinction appears not to be
      absolute. There is now wide acceptance of the view that some dreaming that is
      indistinguishable from REM sleep dreaming occurs in NREM sleep, most frequently in the
      sleep-onset period. General anesthesia causes a drug-induced state of unconsciousness and is
      a non-physiological process that is similar to natural sleep. Patients receiving propofol for
      maintenance of general anesthesia often report higher incidences of dreaming than patients
      maintained with volatile anesthetics. One explanation is that propofol and volatile
      anesthetic have different pharmacological effects in the central nervous system. An
      alternative explanation is that propofol is associated with more rapid emergence from
      anesthesia than the older volatile anesthetics, allowing patients to report their dreams
      before they are forgotten. In order to further verify the hypothesis, the investigators
      choose gynecological general anesthesia to observe whether the generation of dreams is
      related to the dose of general anesthesia maintenance .
    


Intervention name(s): Propofol
Intervention type(s): Drug
Intervention description(s): The low maintenance dose propofol group was maintained at 4-6 mg/kg/h ；and The high maintenance dose propofol group was maintained at 8-12 mg/kg/h
Intervention MeSH terms: Propofol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Study to Assess the Effect of Diets With Different Protein Composition - Mainly Coming From Lean Red Meat - in Body Weight and Lipid Profile in Overweight and Obese Women
Condition: Weight Loss; Obesity; Overweight; Diet, Reducing; Lipids
MeSH terms: Overweight; Body Weight; Weight Loss
Study type: Interventional

Summary: 
      The objective of the study is to assess the effect of diets with different protein
      composition (20%, 27% and 35%), mainly coming from animal proteins such as lean red meat, on
      body weight and lipid profile in overweight and obese women. A dietary intervention is
      carried out during 3 months in 90 women who are individually randomized to an hypocaloric
      diet with three types of macronutrient composition: 1) 35% proteins, 30% fat and 35%
      carbohydrates; 2) 27% proteins, 30% fat and 43% carbohydrates and 3) 20% proteins, 30% fat
      and 50% carbohydrates. Around 50% of total proteins in diet come from lean red meat (leg or
      shoulder of lamb) by providing up to 15 different recipes to participants to use them as part
      of the diet. At the beginning of the study, after 6 weeks and at the end of the intervention,
      the following parameters are determined: anthropometric (weight, waist circumference, body
      mass index and body composition), blood pressure, dietary (72-hours dietary registry) and
      exercise assessments and biochemical analysis (total cholesterol, triglycerides, HDL
      cholesterol, LDL cholesterol, apolipoprotein A1, apolipoprotein B, iron, transferrin,
      ferritin, uric acid, glucose, HbA1c, insulin and adipokines). In 3-months visit, participants
      will be advised to follow the prescribed diets during the next 3 months. Monitoring visits
      with the nutritionist will not be performed. A follow-up visit will be done after 3-months of
      end of intervention (at 6-months after beginning the study) to assess the long-time efficacy
      on main endpoint of each diet. In this visit only anthropometric parameters (weight, waist
      circumference, body mass index and body composition) will be determined.
    


Intervention name(s): Weight loss interventional study with 20% protein-diet; Weight loss interventional study with 27% protein-diet; Weight loss interventional study with 35% protein-diet
Intervention type(s): Behavioral; Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Weight Loss; Obesity; Overweight; Diet, Reducing; Lipids
Study Evaluating the Effectiveness of the Use of Prosthesis With Trans-Obturator Way for the Correction of Anterior Prolapse
Condition: Anterior Prolapse
MeSH terms: Prolapse
Study type: Interventional

Summary: 
      The classical surgical treatment of an anterior prolapse is the use of autologous tissue. In
      front of the high rate of recurrences with this technique, the use of synthetic prosthesis
      made their appearance. But the drawback of the use of prosthesis is their tolerability. The
      system Perigee®, a prosthetic kit by trans-obturator way, was designed to obtain high
      efficiency in the correction of the prolapse while reducing the risk of complications. The
      lack of prospective and randomized studies makes difficult to assess the interest. The
      investigators, therefore, have put in place a randomized prospective study seeking the
      evaluation of the system Perigee® compared to the conventional surgical technique.
    


Intervention name(s): Traditional surgery; Perigee® prosthesis
Intervention type(s): Procedure; Device
Intervention description(s): Traditional surgical method without prosthesis (correction of the anterior prolapse through vaginal tract with the use of autologous tissue).; Surgical method with Perigee® prosthesis
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: correction of anterior prolapse; prosthetic trans-obturator way kit; randomized study
Oxycodone for Labor Pain - Pharmacokinetics (PK), Safety and Efficacy
Condition: Labor Pain
MeSH terms: Labor Pain
Study type: Interventional

Summary: 
      Childbirth is one of the most painful events that a woman is likely to experience, and thus
      is a major concern for most parturient. Severe pain releases stress mediators and may thus
      compromise fetus well-being if placental perfusion is decreased. Epidural analgesia is the
      golden standard for the management of severe labor pain. However, it could not always be used
      both due the parturient related factors and the organizational reasons.However, the knowledge
      on safety and efficacy of oxycodone involving mother, fetus and newborn is limited.

      Aim of the study is firstly, to evaluate the efficacy and safety of oxycodone in labor pain
      healthy parturients. Secondly, to measure parturient's blood oxycodone concentration during
      labour and fetal concentration from placental umbilical vein and artery right after birth.
    


Intervention name(s): Oxycodone
Intervention type(s): Drug
Intervention description(s): Intravenous, 1 mg, 5 times, in every 5 minutes, duration of drug administration 25 minutes
Intervention MeSH terms: Oxycodone
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Oxycodone; Labour pain; Pregnancy; Pregnant women
Vitamin D in Systemic Sclerosis Patients With Periodontitis
Condition: Vitamin D Deficiency
MeSH terms: Periodontitis; Scleroderma, Systemic; Scleroderma, Diffuse; Vitamin D Deficiency
Study type: Observational

Summary: 
      Vitamin D has been considered to possess anti-inflammatory and antimicrobial activity which
      may be a link for the known interaction of Systemic Sclerosis (SSc) and coronary heart
      disease (CHD). This study investigated the association between serum vitamin D levels and SSc
      and periodontitis in patients with SSc, CP and with CHD.

      Furthermore, the objective was to determine if periodontitis and CHD had an impact on serum
      vitamin D levels.
    

Detailed description: 
      Using a cross-sectional design, a total of 42 patients with SSc, 43 patients with CHD, 41
      patients with both SSc and CP, and 42 healthy patients were enrolled in the present study.
    

Intervention name(s): Observation
Intervention type(s): Other
Intervention description(s): Evaluation of Vitamin D levels and correlation of Vitamin D levels level with periodontal and cardiovascular disease
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        42 patients with SSc, 43 patients with CHD, 41 patients with both SSc and CP, and 42
        healthy patients were enrolled in the present study
N-acetylcysteine in the Treatment of PTSD and Addiction
Condition: PTSD; Addiction
MeSH terms: Behavior, Addictive
Study type: Interventional
Phase: Phase 2

Summary: 
      Examine the effects of N-acetylcysteine on PTSD symptoms, craving and substance use in
      veterans with PTSD and comorbid substance use disorders.
    

Detailed description: 
      With the increased number of military veterans returning from conflicts in Afghanistan and
      Iraq diagnosed with posttraumatic stress disorder (PTSD), there is a high vulnerability of
      these individuals to develop a substance use disorder (SUD). While there have been a host of
      studies focused largely on dopaminergic mechanisms of drug reward, they have not led to the
      development of adequate treatments for either preventing people diagnosed with PTSD from
      developing SUD or for treating comorbid PTSD/SUD. Based on extensive work with addictive
      drugs and preliminary data from our group, the investigators propose that stress impairs
      prefrontal cortex regulation of the basal ganglia habit circuitry and this pathology renders
      PTSD patients susceptible to developing SUD. Moreover, the known effects of addictive drugs
      to further impair prefrontal regulation are synergistic with this pathology, thereby making
      treatment of comorbid PTSD/SUD particularly difficult. Preclinical studies have revealed that
      glutamate levels within the nucleus accumbens have been implicated in drug seeking behavior
      in the animal model of relapse. The amino acid precursor N-acetylcysteine (NAC) appears to
      restore glutamate to normal levels and may also prevent glutamate levels from spiking
      following subsequent stimulant use. The primary goal of the proposed study is to evaluate the
      efficacy and safety of N-acetylcysteine in preventing relapse in drug dependent individuals
      with PTSD or subthreshold PTSD. Veterans with substance use disorders who have achieved at
      lease one week of abstinence will be randomized to either placebo or NAC (2400-3600mg/day)
      for 8 weeks.
    

Intervention name(s): N-acetylcysteine; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): NAC pills were administered each week. NAC is a N acetyl pro-drug of the naturally-occurring amino acid cystine. NAC is a white, crystalline powder with the molecular formula C5H9NO3S and with a molecular weight of 163.2.; Identical looking placebo pills were administered each week.
Other intervention name(s): NAC
Intervention MeSH terms: Acetylcysteine; N-monoacetylcystine
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Visual Acuity After Using A New Monofocal Intraocular Lens Compared To Standard Monofocal Lens
Condition: Lenses, Intraocular
Study type: Interventional

Summary: 
      This is a prospective comparative interventional clinical study, that took place from January
      2021 to November 2021. Twenty patients (20) were enrolled in this study 10 patients in each
      group. It was designed for comparison of uncorrected and best corrected distance and
      intermediate vision in patients whom implanted with monofocal Tecnis Eyhance or Tecnis
      1-piece IOLs.
    

Detailed description: 
      Purpose To determine the Uncorrected and best-corrected distance, and intermediate visual
      acuity in a new innovative monofocal intraocular lens compared with standard monofocal lens.

      Methods This is a prospective comparative interventional clinical study, that took place from
      January 2021 to November 2021. 40 eyes of Twenty patients (20) were enrolled in this study,
      patients who are candidates for cataract extraction by phacoemulsification were included in
      this study and underwent thorough preoperative examination and post-operative evaluation at 3
      months after the 2nd eye operation, of distance, intermediate, near add, contrast sensitivity
      and incidence of photic phenomena using a printed questionnaire for evaluating this incidence
      and binocular defocus curves were analyzed.
    

Intervention name(s): phacoemulsification; monofocal intraocular lens implantation
Intervention type(s): Procedure; Procedure
Intervention description(s): cataract extraction followed by bilateral implantation of Eyhance intraocular lens in 10 patients and bilateral implantation of Tecnis 1 piece IOL in 10 patients; implantation of monofocal intraocular lens in the capsular bag at the end of phacoemulsification surgery
Other intervention name(s): cataract extraction
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: This is a prospective comparative interventional clinical study,
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: intraocular lens; intermediate vision; contrast sensitivity; monofocal
A Study of Canagliflozin and Metformin Immediate Release (150 mg/500 mg) FDC Tablets in Healthy Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the bioequivalence of fixed dose combination (FDC)
      tablets of canagliflozin and metformin immediate release (IR) in comparison with the
      individual components of the FDC tablets (canagliflozin and metformin IR).
    

Detailed description: 
      This is an open-label (identity of study drug will be known to volunteer and study staff),
      single-center study to evaluate the bioequivalence (to see if blood levels of one drug are
      equivalent to blood levels of another drug) of canagliflozin and metformin IR when
      administered orally (by mouth) as individual components (ie, separate tablets of
      canagliflozin and metformin IR) (Treatment A) and when administered as FDC tablets (ie,
      canagliflozin and metformin IR contained in the same tablet) (Treatment B). Healthy
      volunteers participating in the study will be randomly (by chance) assigned to receive a
      single dose of Treatment A followed by a single dose of Treatment B or Treatment B followed
      by Treatment A with a period of approximately 15 days between treatments. The total duration
      of the study will be approximately 51 days.
    

Intervention name(s): Canagliflozin tablets; Metformin IR tablets; Canagliflozin/metformin IR FDC tablets; Canagliflozin tablets; Metformin IR tablets; Canagliflozin/metformin IR FDC tablets
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Type = exact number, unit = mg, number = 300, form = tablet, route = oral use. One canagliflozin tablet taken orally (by mouth) on Day 1 of Treatment Period 1.; Type = exact number, unit = mg, number = 500, form = tablet, route = oral use. Two metformin IR tablets taken orally (by mouth) on Day 1 of Treatment Period 1.; Type = exact number, unit = mg, number = 50/500, form = tablet, route = oral use. Two Canagliflozin/metformin IR FDC tablets taken orally on Day 1 of Treatment Period 2.; Type = exact number, unit = mg, number = 300, form = tablet, route = oral use. One canagliflozin tablet taken orally (by mouth) on Day 1 of Treatment Period 2.; Type = exact number, unit = mg, number = 500, form = tablet, route = oral use. Two metformin IR tablets taken orally (by mouth) on Day 1 of Treatment Period 2.; Type = 2, unit = mg, number = 50/500, form = tablet, route = oral use. Two Canagliflozin/metformin IR FDC tablets taken orally on Day 1 of Treatment Period 1.
Other intervention name(s): Treatment A (Reference); Treatment A (Reference); Treatment B (Test); Treatment A (Reference); Treatment A (Reference); Treatment B (Test)
Intervention MeSH terms: Metformin; Canagliflozin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Healthy Volunteers; Bioequivalence; Canagliflozin (JNJ-28431754); Metformin IR
Continuous Positive Airway Pressure Effect on Air Trapping in Chronic Obstructive Pulmonary Disease Patients
Condition: Chronic Obstructive Pulmonary Disease
MeSH terms: Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Study type: Interventional

Summary: 
      Chronic obstructive pulmonary disease is a disease characterized by small airways
      inflammation and obstruction. The small airways disease produces hyperinflation (air
      trapping), which increases with exercise. Continuous positive airways pressure may reduce
      small airways obstruction and therefore air trapping. Pulmonary function tests including lung
      volumes at rest and and after exercise will be measured. In addition, exercise endurance time
      before treatment and after treatment will be measured.
    

Detailed description: 
      Continuous positive airways pressure which prevent small air ways collapse and may also clear
      secretions. At first stage the optimal pressure for reducing air trapping will be determined.
      In addition, all patients will undergo a maximal exercise test. A baseline complete pulmonary
      function test is performed followed by continuous positive air way pressure at the
      pre-determined pressure. This will be followed by exercise at 60% of maximal obtained
      previously.
    

Intervention name(s): positive ventilation
Intervention type(s): Device
Intervention description(s): 10 minutes of increased 4,7,12 positive pressure ventilation
Other intervention name(s): CPAP
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: COPD; CPAP; Sham; FEV1; IC; RV/TLC
Soft Peripheral Contact Lens for Eye Elongation Control (SPACE):1-year Results of a Double-blinded Randomized Con-trolled Trial
Condition: Soft Contact Lens
Study type: Interventional

Summary: 
      A prospective, randomised, double-blinded clinical trial was conducted including 115 children
      (55 male and 60 female) aged 8 to 15 years. The newest multifocal contact lenses were
      assigned to experimental group, and another commercial dual-focus optical designed contact
      lenses were assigned to control group to be worn for at least 8 hours per day, 7 days a week,
      for a period of 1 year. All contact lenses were replaced with new lenses every day.
      Measurements obtained using a LogMAR vision meter, including automated computerised
      optometry, handheld retinoscopy, high (96%) and low (12%) contrast sensitivity visual acuity
      values at a distance, and near-visible acuity values were used to evaluate the corneal
      curvature using a corneal mapper. Additionally, the axial length(AXL) of the eye was
      measured, and the tear quality was assessed using a slit lamp, including tear break-up time,
      tear river height, and observation of blink frequency. Furthermore, the eye's anterior
      surface was examined by slit lamp using the Efron grading scale.
    


Intervention name(s): soft contact lens
Intervention type(s): Other
Intervention description(s): soft contact lens
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Keywords: axial length; children; myopia control; soft contact lens; clinical trials
Interval Training in Young Healthy Individuals
Condition: Healthy Subjects; Exercise Test
Study type: Interventional

Summary: 
      Individuals who participate in regular physical exercise possess a lower prevalence of
      cardiovascular risk factors such as hypertension, type 2 diabetes, obesity and
      hypercholesterolemia, and aerobic exercise is therefore considered an important adjuvant
      therapy in risk factor modification and to promote health.

      The main focus of the present study is therefore to detect how rapid it is possible to
      increase aerobic capacity with interval running exercise.

      The hypothesis is that it is possible to improve maximal oxygen uptake faster when increasing
      training frequency. The total gain in maximal oxygen uptake will however be the same between
      the two groups when they have performed the same amount of training
    

Detailed description: 
      We will perform aerobic interval training at an intensity of 90-95% of maximum heart rate in
      healthy individuals. The subjects will be randomly assigned to carry out a total of 24
      exercise-sessions, either at 3 times per week or 8 times per week.

      The two groups will carry out 24 training sessions before 8 weeks of detraining will provide
      how rapidly aerobic capacity is lost due to inactivity. After the detraining period a
      retraining phase is introduced to detect if improvements in aerobic capacity occur more
      rapidly compared to before the first training period

      The subjects will be tested for oxygen uptake, pumping capacity of the heart, blood volume,
      skeletal muscle enzyme activity, endothelial function.
    

Intervention name(s): High frequency training; normal frequence training
Intervention type(s): Behavioral; Behavioral
Intervention description(s): 24 training sessions, 8x weekly, followed by detraining phase 8 weeks, and retraining; 24 training sessions, 3x weekly, followed by detraining phase 8 weeks, and retraining
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Exercise test; Running; Arterial diameter; Monitoring, physiologic; Oxygen Consumption