Electrophysiological Findings in Fibromyalgia Patients
Condition: Fibromyalgia
MeSH terms: Fibromyalgia; Myofascial Pain Syndromes
Study type: Interventional

Summary: 
      Fibromyalgia Syndrome (FMS); It is a chronic condition characterized by widespread body pain,
      sleep disturbance, fatigue, impaired cognitive functions, and anxiety (1). FMS; chronic
      fatigue syndrome, interstitial cystitis, irritable bowel syndrome, temperomandibular joint
      dysfunction, myofascial pain, functional dyspepsia, restless leg syndrome and posttraumatic
      stress disorder are among central sensitization syndromes (2,3).
    

Detailed description: 
      Etiology and pathogenesis in fibromyalgia have not been fully elucidated. Many mechanisms
      contribute to the formation of FMS. Many evidence has been found for dysfunction of the
      central and autonomic nervous system, immune system, cytokines, neurotransmitters and
      hormones, which are thought to play a role in the disease.

      Since increasing systemic inflammation is thought to have a role in the etiopathogenesis of
      FMS, there are increasing numbers of studies focusing on this aspect of fibromyalgia.

      Neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR) in peripheral blood
      are simple markers of systemic inflammatory response.

      Another factor thought to have a role in etiopathogenesis is autonomic nervous system
      dysfunction. It has been found that there is autonomic dysfunction in the sympathetic nervous
      system in patients with FMS. Sympathetic skin response measurements are frequently used
      electrophysiological methods to evaluate the functionality of the sympathetic nervous system,
      which is a component of the autonomic nervous system.

      In addition, vitamin D deficiency is common in FMS patients. In a study, inadequate vitamin D
      levels were found in 45% of fibromyalgia patients.

      When a literature review is performed, it is seen that electrophysiological studies are
      performed to evaluate autonomic dysfunction in patients with fibromyalgia. No studies were
      found showing the relationship between vitamin D levels and inflammatory parameters in
      patients with fibromyalgia and electrophysiological findings. In our study, it was aimed to
      compare the autonomic dysfunction of fibromyalgia patients with healthy volunteers by
      electrophysiological evaluation and to investigate the relationship between vitamin D levels
      and inflammatory parameters in fibromyalgia patients and the data obtained from
      electrophysiological studies. In this way, we aimed to contribute to a better understanding
      of the physiopathology of fibromyalgia patients with autonomic dysfunction.
    

Intervention name(s): sympathetic skin response measurement
Intervention type(s): Other
Intervention description(s): Sympathetic skin response(SSR) was studied with upper and lower extremity hand and foot recording of all participants, and amplitude and latency values will be recorded. SSR measurement will be made at room temperature of 25 ºC, while the patients are resting in the supine position. 6 mm silver disc electrodes will be used as the recording electrode.
The relationship between the patients' vitamin D levels and inflammatory response markers and their sympathetic skin responses will be investigated by statistical analysis.
Other intervention name(s): measurement of vitamin d levels and hemogram evaluation
Intervention MeSH terms: Vitamin D
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: We have two groups.First group is fibromyalgia patient and second group is healty control.
Masking: None (Open Label)
Primary purpose: Other
Keywords: sympathetic skin response; inflammatory parameters; autonomic dysfunction; autonomic nervous system