Tart Cherry Juice and Chronic Disease Risk
Condition: CVD; Diabetes; Inflammation
MeSH terms: Inflammation
Study type: Interventional

Summary: 
      In this study, the investigators recruited at-risk individuals (n=10) who were overweight
      (25.0-29.9 kg/m2) and obese (> 30.0 kg/m2) and likely to exhibit one or more conditions
      associated with Metabolic Syndrome (MetS). In this 10-week placebo-controlled 2 x 2 crossover
      dietary intervention, the investigators randomized participants (n=10) to consume 240 mL (8
      ounces) daily of either placebo (artificial cherry-flavored, anthocyanin-free beverage) or
      authentic TCJ for 4 weeks, followed by a 2-week washout period, then consumption of the
      alternate beverage for 4 weeks. In this study, the investigators determined the effect of TCJ
      in at-risk participants on markers of inflammation, glycemia, and lipidemia.
    

Detailed description: 
      In this study, the investigators recruited at-risk individuals (n=10) who were overweight
      (25.0-29.9 kg/m2) and obese (> 30.0 kg/m2) and likely to exhibit one or more conditions
      associated with MetS. Participants were >18 years of age, not pregnant, not diabetic, with no
      unresolved infections or diseases (diabetes, CVD, IBD, cancer and liver disease), and
      nonsmokers. Histories of medication and dietary supplement use were collected and those
      taking anti-inflammatory or lipid-lowering medications were excluded. After enrollment,
      subjects were randomly assigned to consume daily either 240 mL (8 ounces) of authentic TCJ
      (R.W. Knudsen, Chico, CA) or a placebo beverage (commercial fruit punch; Great Value,
      Bentonville, AR) for 4 weeks. After a 2-week washout period, participants consumed the
      alternate beverage for 4 weeks in this 10-week 2x2 crossover, placebo-controlled dietary
      intervention. Subsequently, the investigators determined the effect of TCJ in at-risk
      participants on markers of lipidemia (HDL, LDL, triglycerides, VLDL, total cholesterol),
      glycemia (fasting insulin and glucose, HOMA, QUICKI, McAuley indirect indices), and
      inflammation (hsCRP, TNF-alpha, and ESR).
    

Intervention name(s): Placebo; Tart cherry juice
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Participants consumed placebo beverage for 4 weeks.; Participants consumed tart cherry juice (8 ounces; 240 mL) per day for four weeks.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Crossover Assignment In this study, the investigators recruited at-risk individuals who were overweight (25.0-29.9 kg/m2) and obese (> 30.0 kg/m2) and likely to exhibit one or more conditions associated with MetS. In this 10-week placebo-controlled 2 x 2 crossover dietary intervention, the investigators randomized participants to consume 240 mL (8 ounces) daily of either placebo (artificial cherry-flavored, anthocyanin-free beverage) or authentic TCJ for 4 weeks, followed by a 2-week washout period, then consumption of the alternate beverage for 4 weeks. Subsequently, the investigators determined the effect of TCJ in at-risk participants on markers of inflammation, glycemia, and lipidemia.
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: obese; overweight; tart cherry juice