bioihbjkbjnl/mcl2 huggingface dataset:
Acute Effects of TCIG vs ECIG in PLWH
Condition: E Cigarette Use; Vaping; Smoking; Tobacco Smoking; Nicotine Use Disorder; Qt Interval, Variation in; HIV I Infection; Oxidative Stress; Inflammation
MeSH terms: Inflammation; Tobacco Use Disorder
Study type: Interventional

Summary: 
      Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on
      parameters of ventricular repolarization and inflammation/oxidative stress.
    

Detailed description: 
      On separate days, participants will undergo 3 different exposures: an acute e-cigarette
      exposure, an acute tobacco cigarette exposure, and a sham (empty e-cigarette) control .
      Before and after the acute exposure, participants will have blood drawn for
      inflammation/oxidative stress markers and undergo a 5-minute ECG recording.
    

Intervention name(s): TCIG; ECIG; sham control
Intervention type(s): Other; Other; Other
Intervention description(s): Use a TCIG; Use an ECIG; Use a sham control (empty ECIG)
Intervention model: Single Group Assignment
Intervention model description: Crossover with 1 week washout
Masking: None (Open Label)
Primary purpose: Basic Science
Telerehabilitation in Individuals Temporomandibular Dysfunction With Bruxism
Condition: Myofascial Pain; Temporomandibular Disorder; Bruxism
MeSH terms: Temporomandibular Joint Disorders; Temporomandibular Joint Dysfunction Syndrome; Bruxism
Study type: Interventional

Summary: 
      The aim of the study is to compare the effects of Home Exercise Therapy (HET) and
      Telerehabilitation in patients with myofascial temporomandibular disorders (TMD)with bruxism.
    

Detailed description: 
      Home Exercise will be Group 1 and Telerehabilitation group will be Group 2.

      Group 1 HET, will include an educational training program about parafunctional activities of
      TMD disorders and bruxism and active exercises for 4 weeks.

      As part of the Home exercise program, a written document will be prepared, including
      relaxation, breathing training, posture, stretching, and strengthening exercises to be given
      to the patients.

      Group 2, in addition to the training and written document, the second group will receive the
      same exercises using telerehabilitation once a week by video call, and reminder messages will
      be sent to the patients 3 times a week.
    

Intervention name(s): Home Exercise Group; Telerehabilitation Group
Intervention type(s): Procedure; Procedure
Intervention description(s): Educational training program about bruxism and the other oral parafunctional activities in patients with myofascial temporomandibular disorders.; Telerehabilitation program combined with educational training program about bruxism and the other oral parafunctional activities in patients with myofascial temporomandibular disorders.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Myofascial Pain; Temporomandibular Disorder; Bruxism; Telerehabilitation
Clinical Efficacy of Conservative Treatment in Female Patients With Plevic Congestion Syndrome
Condition: Pelvic Congestion Syndrome
MeSH terms: Syndrome
Study type: Observational

Summary: 
      The article presents the results of a randomized, placebo-controlled study of the
      conservative treatment with Daflon (Detralex) in female patients with Pelvic congestion
      syndrome .
    


Intervention name(s): Daflon
Intervention type(s): Drug
Intervention description(s): All consecutive patients were randomly allocated into 2 groups to receive Daflon (Detralex) at a dose of 1000 mg once daily (study group) or placebo (control group).
Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        women with Pelvic congestion syndrome
Study of the Cabochon System for Improvement in the Appearance of Cellulite
Condition: Gynoid Lipodystrophy
MeSH terms: Lipodystrophy; Cellulite
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the safety and effectiveness of the Cabochon System
      for the improvement in the appearance of cellulite.
    


Intervention name(s): Subcutaneous tissue release with the Cabochon System
Intervention type(s): Device
Intervention description(s): Device: Subcutaneous tissue release
Other intervention name(s): Cellfina®
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Life Skills Intervention for Adolescents Perinatally Infected With HIV
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Interventional

Summary: 
      The life skills intervention model is designed to help adolescents promote their physical and
      mental health through cognitive and behavioral techniques (e.g., problem solving, coping, and
      communication skills) designed to help them achieve social and personal competencies used to
      manage various life challenges.
    

Detailed description: 
      One of the salient advantages of this intervention model is that it has been developed and
      implemented in several studies with adolescents. However, data concerning the effects of this
      model are much less extensive with adolescents perinatally infected with HIV. The proposed
      study is designed to address this gap in knowledge by conducting a pilot intervention
      tailoring the life skills intervention to the needs of young adolescents, perinatally
      infected with HIV, and to their primary caregivers. Given the emphasis on peer group
      interaction, the proposed intervention model also has the potential to reduce some of the
      social isolation imposed by the experiences related to HIV infection by creating
      opportunities for adolescents to interact with others who are managing comparable stressors
      and treatment regimens.
    

Intervention name(s): Life Skills Intervention
Intervention type(s): Behavioral
Intervention description(s): Developed to promote life skills among young adolescents perinatally infected with HIV
Other intervention name(s): No other names.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: HIV; AIDS; Adolescent; HIV Positive
Comparison Mydriasis by Mydrane With Topical Drop Application
Condition: Cataract
MeSH terms: Cataract; Mydriasis
Study type: Interventional
Phase: Phase 4

Summary: 
      The primary aim of the study is to compare the effectiveness of the intracameral application
      of Mydrane® (standardized combination of Tropicamide 0.02%, Phenylephrine 0.31% and Lidocaine
      1%) with the preoperative topical application (Tropicamide 0.5% and Phenylephrine 10%). To
      evaluate the steadiness of the dilating effect on the pupil, the ratio of eyes without
      necessity for further pupil dilating procedures to perform the capsulorhexis is assessed.
    


Intervention name(s): Eye injection (Mydrane); eye drops (Phenylephrin); eye drops (Tropicamid)
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Mydrane 0.2 mg/ml + 3.1 mg/ml
+ 10 mg/ml solution for injection tropicamide / phenylephrine hydrochloride / lidocaine hydrochloride; Phenylephrine 10%; Tropicamid 0,5%
Other intervention name(s): Mydrane; Minims; Agepha
Intervention MeSH terms: Ophthalmic Solutions
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Treatment
A Pharamcogenomic Study for Isoniazid According to NAT2 Polymorphism Status
Condition: Tuberculosis; Drug-Induced Liver Injury; Adverse Drug Event
MeSH terms: Tuberculosis; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions
Study type: Interventional

Summary: 
      A clinical trial to investigate the appropriate dose of isoniazid according to NAT2
      polymorphism status in Korean subjects
    


Intervention name(s): Isoniazid
Intervention type(s): Drug
Intervention description(s): One of the first line anti-tubercolosis drug
Intervention MeSH terms: Isoniazid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Self Drainage in Pediatric Cystic Fibrosis Patients
Condition: Cystic Fibrosis
MeSH terms: Cystic Fibrosis; Fibrosis
Study type: Interventional

Summary: 
      In the current study, we designed a cross-over, open label, randomized controlled clinical
      trial that aim to investigate the superiority of physical exercise coupled with self drainage
      to a chest physiotherapy in stable cystic fibrosis children. We hypothesized that CF children
      undergoing physical exercise coupled to self drainage will increase the amount of expectorate
      secretions compared to conventional CP course, while being more satisfied and without
      worsening their pulmonary function status.
    


Intervention name(s): Chest physiotherapy
Intervention type(s): Procedure
Intervention description(s): The whole exercise session consisted of three short period of exercise of 5 minutes each entirely done under the physiotherapists' supervision (FA).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: cystic fibrosis; Lung function; physical exercise
Pharmacokinetics of Progesterone in Pregnancy
Condition: Progesterone
Study type: Interventional
Phase: Phase 1

Summary: 
      Pharmacokinetic analysis of 200mg vaginal progesterone suppository in women with singleton
      pregnancies between 18 0/7- 23 6/7 weeks' gestation
    

Detailed description: 
      Prospective study of 6 women with singleton pregnancies 18 0/7- 23 6/7 weeks' gestation with
      no prior preterm birth or short cervix who are administered a single dose of 200mg vaginal
      progesterone suppository. Serum progesterone levels will be drawn serially from pre-dose to
      24 hours post-dose.
    

Intervention name(s): vaginal progesterone suppository
Intervention type(s): Drug
Intervention description(s): 200mg vaginal suppository micronized progesterone
Intervention MeSH terms: Progesterone
Intervention model: Single Group Assignment
Intervention model description: Pharmacokinetic study to assess plasma concentration time profile of vaginal progesterone in pregnant women.
Masking: None (Open Label)
Primary purpose: Other
Keywords: progesterone; pharmacology; pharmacokinetics
Success of Internal Jugular Vein Catheterization
Condition: Ultrasound; Catheterization; Volume Status
Study type: Interventional

Summary: 
      Internal jugular vein cannulation can be performed with the blind technique under ultrasound
      (USG) guidance or using classical marker points. It has been shown that USG-guided
      interventions reduce the complication rate compared to the method performed with the blind
      technique (4%/13.5%). In addition, the initial entry success rate in the USG supported group
      is 65%. , this rate remained at 45% with the blind technique.

      Although Pleth variability index monitoring is a noninvasive method, it is a technique that
      consistently predicts fluid sensitivity in patients under mechanical ventilation.

      The aim of study is before applying USG guided catheterization; We think that by revealing
      the factors of the patient that are effective on the number of interventions, necessary
      measures can be taken for the success of catheterization as a result.
    


Intervention name(s): Internal Jugular Vein Catheterization
Intervention type(s): Procedure
Intervention description(s): Inserting a cannula into the internal jugular vein
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Care Provider)
Primary purpose: Supportive Care
Keywords: juguler vein catheterization; ultrasound guidance; pleth variability index
Clinicopathological Profile of Head and Neck Cancers in Army Hospital of Nepal
Condition: Head and Neck Cancer
MeSH terms: Head and Neck Neoplasms
Study type: Observational

Summary: 
      This is a observational study conducted at the department of Ear ,Nose and Throat -Head and
      Neck Surgery (ENT-HNS) of Shree Birendra Hospital ,a tertiary health care centre of Nepal.
      Head and Neck cancers are the sixth most common cancer in the world. Data was collected from
      the medical records of Head and Neck Cancer patients who underwent treatment between May 2022
      to April 2023.The main aim of the study was to know about the common cancers of head and neck
      region and their distribution according to the site. Also to know the stage of the
      presentation with treatment modalities in the tertiary health care centre of Nepal.
    

Detailed description: 
      This is a retrospective study to know the prevalence of Head and Neck Cancer at the
      department of ENT- Head and Neck Surgery of Shree Birendra Hospital ,a tertiary health care
      centre of Nepal .Head and neck cancers are malignant neoplasms that develops in oral cavity,
      nasal cavities, paranasal sinuses,nasopharynx, oropharynx, hypopharynx, ear, scalp, salivary
      gland and neck,Data was collected from the medical records of Head and Neck Cancer patients
      who underwent treatment between May 2022 to April 2023. Data considered of demographic
      details of age, sex, diagnosis, subsite specific Head and Neck Cancers, treatment modality
      and histopathology. The data was analyzed using Stastical Package for Social Sciences (SPSS)
      version 22. Pearson's chi-square test was applied and p value <0.05 was considered
      statistically significant.
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Study population was selected from the tertiary care centre of Nepal.
      
Keywords: Head and Neck Cancer; Radiotherapy; Chemotherapy
The Relative Bioavailability Study of Two Ropinirole 0.25 mg Tablets Under Fed Conditions
Condition: Healthy
MeSH terms: Malnutrition
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to compare relative bioavailability of the test formulation of
      ropinirole hydrochloride 0.25 mg tablets (Manufactured and distributed by TEVA
      Pharmaceuticals USA) with the already approved formulation REQUIP® (ropinirole hydrochloride)
      0.25 mg tablets (GlaxoSmithKline) under fed conditions in healthy, adult subjects.
    

Detailed description: 
      Criteria for Evaluation: FDA Bioequivalence Criteria

      Statistical Methods: FDA bioequivalence statistical methods
    

Intervention name(s): Ropinirole HCl 0.25 mg Tablets; Requip® 0.25 mg Tablets
Intervention type(s): Drug; Drug
Intervention description(s): 1 x 0.25 mg, single dose fed; 1 x 0.25 mg, single dose fed
Intervention MeSH terms: Ropinirole
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: Bioequivalence; Healthy Subjects
Testing The Effectiveness Of Celecoxib In Patients With Painful Sore Throat
Condition: Pharyngitis
MeSH terms: Pharyngitis
Study type: Interventional
Phase: Phase 3

Summary: 
      We are proposing a study in which we utilize and augment the sore throat pain model to assess
      the analgesic effectiveness of celecoxib compared to placebo in patients with painful
      pharyngitis under randomized, double-blind, placebo-controlled conditions.
    


Intervention name(s): Celecoxib; Celecoxib; celecoxib; placebo
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): dose 1 celecoxib 50 mg followed 6-12 hours later by dose 2 celecoxib 50 mg; dose 1 celecoxib 100 mg followed 6-12 hours later by dose 2 placebo; dose 1 celecoxib 100 mg followed 6-12 hours later by dose 2 celecoxib 50 mg; dose 1 placebo followed 6-12 hours later by dose 2 placebo
Intervention MeSH terms: Celecoxib
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: sore throat; acute pain
Exercise and Manual Therapy for Shoulder Subacromial Impingement Syndrome
Condition: Shoulder Impingement Syndrome
MeSH terms: Shoulder Impingement Syndrome; Syndrome; Rotator Cuff Injuries
Study type: Interventional
Phase: Phase 2

Summary: 
      The purposes of this study are to:

        1. determine if a rehabilitation program that consists of exercise and manual therapy
           reduces pain and improves quality of life in patients with shoulder subacromial
           impingement syndrome;

        2. determine which patients are likely to respond to this rehabilitation program and which
           patients are not likely to respond to this rehabilitation program

      The hypotheses are:

        1. the rehabilitation treatment program will result in significant changes in pain and
           quality of life

        2. there will be items from the history and examination that will identify those patients
           who respond favorably and those who do not respond favorably to rehabilitation at 6
           weeks, 3, 6 and 12 months.
    

Detailed description: 
      Subacromial impingement syndrome (SAIS) is the most frequent cause of shoulder pain. A
      variety of non-surgical treatments have been advocated to correct the impairments associated
      with SAIS. Clinical trials support the use of therapeutic exercise and joint mobilizations to
      improve pain and functional disability associated with SAIS. However, not all patients in
      these trials had a favorable outcome. Moreover, the effect sizes in these trials were small
      to moderate. Thus the purposes of this study are to 1. determine the effect of a multi-modal
      rehabilitation program consisting of strengthening, stretching, manual therapy to the
      shoulder and spine, patient education, posture, and functional re-training; and 2. identify
      those patients who are and who are not likely to respond to rehabilitation at the start of
      care.
    

Intervention name(s): Rehabilitation
Intervention type(s): Other
Intervention description(s): Exercise, manual therapy, patient education, posture, home exercise program
Other intervention name(s): Physical Therapy; Manual Therapy
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: shoulder pain; shoulder impingement syndrome; manual therapy; rehabilitation
Patient Satisfaction and Pain Control Following Reconstructive Vaginal Surgery
Condition: Post Operative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      The investigators hypothesize that patient controlled analgesia (PCA) provides superior pain
      relief and patient satisfaction when compared to scheduled intravenous analgesia following
      vaginal reconstructive surgery.
    

Detailed description: 
      The investigators hypothesize that patient controlled analgesia (PCA) provides superior pain
      relief and patient satisfaction when compared to scheduled intravenous analgesia following
      vaginal reconstructive surgery.

      In order to determine if there is a significant correlation, secondary outcomes will include
      the daily and total narcotic volume used, common side effects from the opioid including
      nausea, vomiting, or pruritis, length of hospital stay, timing of flatus and first bowel
      movement, all complications, and procedure performed.
    

Intervention name(s): Dilaudid PCA; Dilaudid IV Scheduled
Intervention type(s): Drug; Drug
Intervention description(s): PCA setting of 0.3mg demand dose, 8 minute lock out interval, and 5mg 4-hour limit.; Nurse administered IV Dilaudid 0.5mg every 2 hours.
Other intervention name(s): hydromorphone; hydromorphone
Intervention MeSH terms: Hydromorphone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: vaginal reconstructive surgery
Opioid Sparing Anaesthesia for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgery
Condition: PONV; Opioid Sparing Anaesthesia
MeSH terms: Vomiting; Postoperative Nausea and Vomiting
Study type: Interventional
Phase: Phase 4

Summary: 
      In spite of multimodal analgesic strategies, which consist of opioids, dexamethasone,
      non-steroidal anti-inflammatory drugs, and local anesthetics applied into the surgical wound,
      postoperative pain and postoperative nausea and vomiting (PONV) are still common complaints
      reported after laparoscopic gynecological surgery.

      So, it is hypothesized that the infusion consisting of lidocaine, dexmedetomidine and
      ketamine, as an opioid substitute was a feasible technique for laparoscopic gynecological
      surgery and would be associated with less incidence of PONV and lower opioid requirements in
      the early postoperative period.

      The aim of this study was to evaluate the effect of opioid sparing technique via infusion of
      Dexmedetomidine, Ketamine and Lidocaine on post-operative nausea and vomiting in laparoscopic
      gynecological surgery.
    


Intervention name(s): Dexmedetomidine, ketamine and lidocaine; Normal saline
Intervention type(s): Drug; Drug
Intervention description(s): A loading infusion of syringe (B) containing the a mixture [dexmedetomidine (2 µg/ml), ketamine (0.5 mg /ml) and lidocaine (4 mg /ml)] was started at rate of 0.2 ml/kg/h ten minutes before induction. Then anesthesia was induced with 2 mg/kg IBW of propofol, patients were intubated with the aid of 0.5 mg/kg IBW atracurium and received 0.1ml/kg from syringe (D) containing normal saline (as masking for fentanyl in the control group).; A loading infusion of the 50 ml syringe (A) containing normal saline was started at rate of 0.2 ml/ kg/hr ten minutes before induction (as masking for mixture in group S). Then anesthesia was induced with 2 mg/kg ideal body weight (IBW) of propofol , patients were intubated with the aid of 0.5 mg/kg IBW atracurium and received 0.1ml/kg from syringe (C) containing fentanyl (1mic/kg of IBW).
Intervention MeSH terms: Lidocaine; Dexmedetomidine; Ketamine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Laparoscopic Gynecological Surgery; Dexmedetomidine; Ketamine; Lidocaine; PONV
Evaluation of Tiotropium 5 µg/Day Delivered Via the Respimat® Inhaler Over 48 Weeks in Patients With Severe Persistent Asthma on Top of Usual Care (Study II)
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 3

Summary: 
      The trial is a randomised, double-blind, placebo-controlled, parallel-group trial to evaluate
      the efficacy and safety of 5 µg tiotropium over a 48-week treatment period as compared to
      placebo. Tiotropium inhalation solution delivered by the Respimat® inhaler will be examined
      as add-on controller therapy on top of usual care in patients with severe persistent asthma.
      The primary objective of each trial is to evaluate the long term efficacy of tiotropium over
      placebo on top of usual care in patients with severe persistent asthma as determined by
      pulmonary function testing, effects on asthma exacerbations, effects on quality of life, on
      asthma control and health care resource utilisation. The secondary objective of each trial is
      to compare the long term safety of tiotropium with placebo in this patient population.
    


Intervention name(s): tiotropium 5mcg/day; placebo
Intervention type(s): Drug; Drug
Intervention description(s): Intervention = Randomisation: patient to receive double-blind treatment with either 5mcg/day tiotropium inhalation solution or placebo inhalation solution; Intervention = Randomisation: patient to receive double-blind treatment with either 5mcg/day tiotropium inhalation solution or placebo inhalation solution
Intervention MeSH terms: Tiotropium Bromide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment