bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Beta-blockade on Platelet Aggregation in Acute Coronary Syndrome
Condition: Acute Coronary Syndrome
MeSH terms: Acute Coronary Syndrome; Syndrome
Study type: Interventional
Phase: Phase 4

Summary: 
      The Investigators will test the hypothesis that nonselective beta-blockers would have a more
      pronounced effect on platelet aggregation than selective beta-blockers in patients with acute
      coronary syndrome treated with dual anti platelet therapy.
    

Detailed description: 
      In patients with acute coronary syndrome (ACS) beta-blockers are recommended for secondary
      prevention. It is known that catecholamine levels can potentiate platelet reactivity and
      beta-blocking agents may also affect platelet aggregation. This effect is mainly mediated by
      adrenergic receptors on platelets. This suggests that nonselective beta-blockers would have a
      more pronounced effect on platelet aggregation than selective beta-blockers. However, little
      is known about the effect of beta-blockers on platelet aggregation in patients with
      cardiovascular disease and, to date, nothing is known in the setting of ACS.

      The aim of the present study is to evaluate the effect of selective and nonselective
      beta-blockers on platelet aggregation in ACS patients treated with dual anti platelet
      therapy.
    

Intervention name(s): Carvedilol; Metoprolol
Intervention type(s): Drug; Drug
Intervention description(s): Patients randomized to this group will receive carvedilol at the highest dose tolerated; Patients randomized to this group will receive metoprolol at the highest dose tolerated
Other intervention name(s): Selective beta-blocker; Non Selective beta-blocker
Intervention MeSH terms: Metoprolol; Carvedilol; Adrenergic beta-Antagonists
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: ACS; Beta Blockers; platelet aggregation; light transmission aggregometry; Beta-Adrenergic Blockers
Risk Factors and Complications Contributing to Mortality in Elderly Patients With Fall-Induced Femoral Fracture
Condition: Femoral Fractures
MeSH terms: Fractures, Bone; Femoral Fractures
Study type: Observational

Summary: 
      This study aimed to identify the risk factors and complications associated with mortality in
      elderly patients with femoral fracture after a fall from the ground level.
    

Detailed description: 
      This retrospective study reviewed data pertaining to elderly patients aged ≥ 65 years who
      were admitted into a Level I trauma center, between January 1, 2009 and December 31, 2017.
      Multivariate logistic regression analysis was performed to identify independent effects of
      univariate predictive variables on the occurrence of mortality.
    

Intervention name(s): Survival; Death
Intervention type(s): Other; Other
Intervention description(s): Elderly patients with fall-induced femoral fracture who were survived.; Elderly patients with fall-induced femoral fracture who were dead.
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        This retrospective study reviewed data from 27,462 trauma patients registered between
        January 1, 2009 and December 31, 2016. The inclusion criteria were age ≥65 years and
        hospitalization for the treatment of femoral fracture following a fall from standing height
        level (<1 m). This study excluded those patients with a fall from ≥1 m as well as those for
        whom incomplete data were available.
      
Keywords: femur fracture; trauma; fall; elderly; mortality; respiratory complication
Head-Mounted Vibrotactile Prosthesis for Patients With Chronic Postural Instability
Condition: Dizziness
MeSH terms: Dizziness
Study type: Interventional
Phase: Phase 1

Summary: 
      The goal of this project is to provide individuals that have a balance deficit with a device
      that will give them signals that they can feel (vibrations) in order to help them maintain a
      correct sense of balance and perception of place in the environment.
    

Detailed description: 
      This proposal addresses a National Institute on Deafness and Other communication Disorders
      (NIDCD) research topic that emphasizes the "development of assistive devices for balance
      disorders". The proposed work will evaluate the assistive efficacy of such a balance
      prosthesis in a population of chronic imbalance patients spanning a wide range of disease
      etiologies.
    

Intervention name(s): balance prosthesis
Intervention type(s): Device
Intervention description(s): vibrotactile stimulation
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Chronic imbalance; vestibular disorders; balance prosthesis
Evaluate Immunogenicity, Safety, and Reactogenicity of Rotavac in Healthy Infants in Vietnam
Condition: Rotavirus Gastroenteritis
MeSH terms: Gastroenteritis
Study type: Interventional
Phase: Phase 3

Summary: 
      An open label study to evaluate immunogenicity, safety, and reactogenicity of Rotavac® (live
      attenuated oral rotavirus vaccine) as a 3-dose series in healthy infants aged between 6 weeks
      and 8 weeks in Vietnam
    

Detailed description: 
      -  The study is an open labeled, clinical trial in infants 6-8 weeks of age will be
           assigned to receive 3 doses of Rotavac® to evaluate the immunogenicity and safety.

        -  Active surveillance will be conducted for all participants for 14 & 28 days after each
           dose of vaccine to obtain information on adverse events. ("Reactogenicity")

        -  Childhood vaccines including pentavalent (Diptheria, Tetanus, Pertussis, Hib, Hepatitis
           B) and oral polio vaccine as well as injectable polio vaccine will be administered along
           with the study vaccines as per Expanded Program on Immunization (EPI)

        -  Safety assessments will include observation in the study clinic for 30 minutes after
           each vaccine administration to record immediate adverse events. A subject diary card and
           personal contact with the subjects will be made to record adverse events during the
           14-day period following vaccine administration.
    

Intervention name(s): Rotavac
Intervention type(s): Biological
Intervention description(s): Rotavac Is a monovalent vaccine containing suspension of live attenuated rotavirus 116E strain, a naturally occurring reassortant strain G9P[11], containing one bovine rotavirus gene P[11] and 10 human rotavirus genes prepared in Vero cells administered orally at 6, 10 and 14 weeks of age.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Biomechanical Analysis of Different Landing Manoevres
Condition: Landing Biomechanics
Study type: Observational

Summary: 
      In this study, three-dimensional biomechanics , by means of lower limb joint angles and
      moments (opto-electronic system with synchronised force plate), of different landing
      manoevres will be compared in a population of basketball and volleyball players.
    

Detailed description: 
      In this study, three-dimensional biomechanics , by means of lower limb joint angles and
      moments (opto-electronic system with synchronised force plate), of different landing
      manoevres will be compared in a population of basketball and volleyball players. General as
      well as more sport-specific jumps will be performed in this study.
    

Intervention name(s): 3D analysis of different landing tasks
Intervention type(s): Other
Intervention description(s): General as well as more sport-specific landing tasks are investigated with 3D analysis by using an opto-electronic system
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Healthy volleyball and basketball players
      
Keywords: landing; biomechanics
Betaine METABOLISM OF PATIENTS With Homocystinuria
Condition: Homocystinuria
MeSH terms: Homocystinuria
Study type: Interventional
Phase: Phase 2

Summary: 
      Oral treatment with betaine is conventionally used for patients with inherited
      homocystinurias.

      These conditions include a first group of patients with a cystathionine β-synthase (CBS)
      deficiency and a second group of patients with remethylation defects.

      The aim of betaine therapy is to reduce level of total plasma homocysteine. Daily dosages and
      rhythm of administration proposed in the literature vary between 100 to 250 mg / kg / d in 2
      to 4 doses. These dosages are not based on validated data and several publications mention
      much higher dosages particularly when total homocysteine is not controlled. These practices
      may be unnecessary or even detrimental given the fact that high doses of betaine could for
      example lead to secondary folate deficiency.
    

Detailed description: 
      Oral treatment with betaine is conventionally used for patients with inherited
      homocystinurias.

      These conditions include a first group of patients with a cystathionine β-synthase (CBS)
      deficiency and a second group of patients with remethylation defects.

      The aim of betaine therapy is to reduce level of total plasma homocysteine. Daily dosages and
      rhythm of administration proposed in the literature vary between 100 to 250 mg / kg / d in 2
      to 4 doses. These dosages are not based on validated data and several publications mention
      much higher dosages particularly when total homocysteine is not controlled. These practices
      may be unnecessary or even detrimental given the fact that high doses of betaine could for
      example lead to secondary folate deficiency.
    

Intervention name(s): Betaine
Intervention type(s): Drug
Intervention MeSH terms: Betaine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Comparison of Left and Right Radial Approach for Percutaneous Coronary Procedures
Condition: Transradial Approach,; Coronary Angiography,; Percutaneous Coronary
Study type: Interventional

Summary: 
      Previous studies have shown that the transradial cardiac catheterization has decreased not
      only bleeding complications related to the access site and procedural discomfort but also
      morbidity and hospitalization as compared to transfemoral approach. At present, the right
      radial approach (RRA) is the first choice routinely for coronary angiography and
      interventions in daily clinical practice despite more marked subclavian artery tortuosity
      than left radial approach (LRA). Although LRA has been thought to be more direct access to
      the ascending aorta similar to transfemoral approach and may reduce fluoroscopy time and
      cerebrovascular complications compared with RRA, the application of LRA for coronary
      intervention is still low. Moreover, several studies have also obtained conflicting results
      showing no difference in procedural success rate compared LRA and RRA using Judkins
      catheters. To date, it remains unclear whether LRA is superior to RRA in term of safety and
      feasibility for coronary angiography and interventions in real world practice and few data of
      randomized control trial are available.

      The aim of this study was to randomly investigate and compare the safety and feasibility of
      LRA compared with RRA for coronary diagnostic angiography in Chinese subjects.

      The investigators will enroll consecutively for 2 years all patients undergoing coronary
      diagnostic procedures through trans radial approach.

      The primary outcome was total procedural duration. Secondary outcomes included fluoroscopy
      time, dose of radiation including cumulative air kerma and dose area product, contrast volume
      and the incidence of vascular complications.
    


Intervention name(s): left radial approach; Right radial approach
Intervention type(s): Procedure; Procedure
Intervention description(s): Coronary diagnostic procedures performed through left radial approach; coronary diagnostic procedures performed through right radial approach
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Transradial approach,; Coronary angiography
Appropriate Laryngeal Mask Airway Size in Patients With Overweight: A Comparison of the Actual Body Weight and Ideal Body Weight
Condition: General Anesthesia
MeSH terms: Body Weight
Study type: Interventional

Summary: 
      The classic laryngeal mask airway is one of the keystones of modern anaesthetic practice. It
      achieves a reliable airway with a low incidence of major complications and
      pharynges-laryngeal morbidity. The manufactures of laryngeal mask airway recommend the proper
      size selection by actual body weight. It was recommended a size 3 for 30-70kg, a size 4 for
      70-90 kg, and size 5 for > 90 kg. Obesity increases the fat tissue around an upper airway and
      decreases the pharyngeal cross sectional area. Also it was reported that pharyngeal area was
      reduced according to the increasing of BMI. Therefore, the aim of this study is to determine
      which of actual body weight or ideal body weight is proper on the size selection of laryngeal
      mask airway.
    


Intervention name(s): actual body weight based size; ideal body weight based size
Intervention type(s): Device; Device
Intervention description(s): According randomized allocated group, the laryngeal mask airway is inserted based on actual or ideal body weight-based sizes before the surgery.; According randomized allocated group, the laryngeal mask airway is inserted based on actual or ideal body weight-based sizes before the surgery.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: general anesthesia; body weight; laryngeal mask airway size
A Comparison of Dorsal Branch of the Digital Nerve Versus Dorsal Digital Nerve for Finger Pulp Reconstruction
Condition: Soft Tissue Defect of the Finger
Study type: Interventional

Summary: 
      As the donor nerve attached with the flap, the dorsal branch of the digital nerve and the
      dorsal digital nerve is commonly used for finger pulp reconstruction.This study compares two
      donor nerves: the dorsal branch of the digital nerve and the dorsal digital nerve.
    

Detailed description: 
      The investigators compares two donor nerves attached with the flap for sensory reconstruction
      of finger pulp: the dorsal branch of the digital nerve and the dorsal digital nerve. The main
      outcomes were static 2-point discrimination and Semmes-Weinstein monofilament scores of the
      flap, and pain and cold intorlence of the reconstructed finger.
    

Intervention name(s): flap includes a donor nerve
Intervention type(s): Procedure
Intervention description(s): the donor nerve is attached with the flap for sensory reconstruction of the finger
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Dorsal digital nerve; dorsal branch of the digital nerve; dorsal branch of the digital artery; dorsal digital island flap; finger pulp defect.
Pharmacodynamics, Pharmacokinetics, and Safety of ASP1941 in Patients With Type 1 Diabetes Mellitus
Condition: Type 1 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Interventional
Phase: Phase 2

Summary: 
      The objective of this study is to assess pharmacodynamics, pharmacokinetics, and safety of
      ASP1941 in patients with type 1 diabetes mellitus when administered once daily (q.d.) for 2
      weeks.
    


Intervention name(s): Placebo; ASP1941
Intervention type(s): Drug; Drug
Intervention description(s): Oral; Oral
Other intervention name(s): Suglat; Ipragliflozin
Intervention MeSH terms: Ipragliflozin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: ASP1941; type 1 diabetes mellitus; SGLT2 inhibitor
Efficacy of Macrolide and Glucocorticoid in the Treatment of Chronic Rhinosinusitis After Endoscopic Sinus Surgery
Condition: Chronic Rhinosinusitis; Endoscopic Sinus Surgery
MeSH terms: Sinusitis
Study type: Interventional

Summary: 
      Endoscopic sinus surgery (ESS) is widely considered to be the gold standard in the surgical
      management of chronic rhinosinusitis (CRS) that has failed maximal medical therapy.
      Nevertheless, the postoperation medical therapy was considered as a crucial procedure for the
      success of ESS. Both glucocorticoids and macrolide antibiotics have been recommended for the
      treatment of CRS, but their effect as postoperation medical therapies of ESS need more
      clinical data to clarify.

      The purpose of this prospective, randomized,study is to determine the effect of
      glucocorticoids and macrolide antibiotics for the postoperation medical therapy of ESS in
      different subtypes of CRS.
    

Detailed description: 
      Chronic rhinosinusitis (CRS) is a multifactorial inflammatory disorder that causes various
      symptoms including nasal obstruction, rhinorrhea, olfactory dysfunction, facial pain, and
      headache . Endoscopic sinus surgery (ESS) is usually recommended for patients who do not
      response well to conservative treatments. Although surgery is effective to alleviate symptoms
      and improve the quality of life of CRS patients, a followed long-term postoperative medical
      treatment is indispensable. Current European and American guidelines recommend
      glucocorticoids and antibiotics as the primary pharmacotherapeutic approaches for CRS before
      and after ESS. However, there are a number of CRS patients not responding well to
      glucocorticoid treatment and conflicting results exist regarding the efficacy of long-term,
      low-dose macrolide treatment. One potential reason is that CRS is a heterogeneous group of
      disorders unified by similar clinical presentations and its phenotypes and/or endotypes may
      be important factors determining the efficacy of treatments.
    

Intervention name(s): Clarithromycin; Glucocorticoid
Intervention type(s): Drug; Drug
Intervention description(s): Clarithromycin 250 mg tablet once daily for 3 months; Fluticasone propionate nasal spray 200 μg/d for 3 months
Other intervention name(s): KLACID; FLIXONASE
Intervention MeSH terms: Clarithromycin; Glucocorticoids
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
To Demonstrate Equivalent Pharmacokinetic Properties of HD204 and Bevacizumab (Avastin®) in Healthy Male Subjects
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to compare the pharmacokinetics, as well as to evaluate the
      safety, tolerability and immunogenicity of HD204, US-Avastin and EU-Avastin in healthy male
      subjects after intravenous administration of a single dose..
    

Detailed description: 
      This is a double-blind, randomized, three-arm, parallel-group, single-dose study. A total of
      120 evaluable subjects are required.
    

Intervention name(s): HD204; Avastin
Intervention type(s): Drug; Drug
Intervention description(s): Single-Dose 1mg/kg body weight by 90 minute intravenous infusion; Single-Dose 1mg/kg body weight by 90 minute intravenous infusion
Other intervention name(s): Bevacizumab; Bevacizumab
Intervention MeSH terms: Bevacizumab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Screening
Keywords: randomized; double-blind
Healing After Connective Tissue Graft Harvesting in the Palatal Area With and Without Suture
Condition: Wound Healing
Study type: Interventional

Summary: 
      This study evaluated the outcomes in the early healing of palatal wounds after harvesting a
      subepithelial connective tissue graft (SCTG) using the single incision technique with
      placement of a collagen haemostatic sponge (CHS) without suturing the palate. The primary
      outcome of this study was to evaluate the early wound healing index (EHI).
    

Detailed description: 
      The aim of this study was to compare the outcomes in the early wound healing after harvesting
      a subepithelial connective tissue graft (SCTG) using the single incision technique and
      collagen haemostatic sponge (CHS) placement, with and without suturing the palate. 36
      subjects were randomized to receive (n=18, Suture group-SG) or not a suture (n=18, no Suture
      group-nSG). Outcomes variables were: Early healing index (EHI) at 7, 14 and 30 days,
      self-reported pain using a visual analogue scale (VAS) at 7 and 14 days, immediate (iB) and
      delayed bleeding (dB). Data obtained were compared by Fisher's exact test, T test for
      independent sample, Mann-Whitney test (U test) and Wilcoxon sign test as appropriate. The
      level of significance was set at p < 0.05. Statistical analysis was performed with Infostat
      version 2015.
    

Intervention name(s): Subepithelial connective tissue graft (SCTG) using the single incision technique, with and without suturing the palate
Intervention type(s): Procedure
Intervention description(s): A SCTG was harvested using the single incision technique described by Hürzeler & Weng. The palatal incisions were standardized to extend between the area between mesial of the canine and mesial of the first molar.In the Suture Group sites a cross- mattress suture and interrupted single sutures were performed using nylon 5-0 when appropriate. In the no Suture Group sites, no suture was performed. In both groups, a CHS was placed after removing the graft to achieve the haemostasis of the palate and subsequent compressed with gauze soaked in saline for 5 minutes.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants were assigned to one of two groups in parallel for the duration of the study: This study was a non-masked, randomized, controlled clinical trial, with a parallel design, comparing early healing of palatal wounds after harvesting subepithelial connective tissue graft using the single incision technique, with and without palatal sutures.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: wound healing; palate; connective tissue harvesting; single incision