The Role Of Fructose and Uric Acid In the Development of Obesity and Metabolic Syndrome
Condition: Overweight and Obesity; Metabolic Syndrome; Hyperuricemia
MeSH terms: Obesity; Overweight; Metabolic Syndrome; Syndrome; Hyperuricemia
Study type: Interventional

Summary: 
      The purpose of this study is to determine if a low fructose intake could have an impact on
      weight loss, uric acid levels and the components of the metabolic syndrome (glucose,
      cholesterol, triglycerides, insulin resistance, high blood pressure).
    

Detailed description: 
      Overweight and obesity are now considered a growing public health problem in Mexico and
      worldwide. This epidemic has been attributed to dietary fructose consumption. Although
      experimental models have demonstrated a role of fructose in the development of obesity,
      metabolic syndrome and kidney disease, data in human models is lacking. The purpose of this
      study is to determine if a low fructose intake could have an impact on the components of the
      metabolic syndrome. The primary endpoint will be to determine the impact of low fructose on
      weight loss. Secondary endpoints will evaluate the impact of low fructose diet on blood
      pressure and cardiovascular biochemical profile.

      If fructose is a causal pathway to obesity and metabolic syndrome, it may represent an
      important target to mitigate this important health problem.
    

Intervention name(s): low fructose; Normal fructose arm
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): patients will receive a low fructose diet to evaluate possible changes in weight loss after a 6 week period of receiving a caloric intake (proteins, fats and carbohydrates) based on their healthy-desired weight. Participants will be randomized to a 1500, 1800 or 2000 kilocalories diet calculated by Harris Benedict equation, thermic effect of foods and energy (without exercise). low fructose arm: a 2 week period of low fructose diet (less than 10 grams/day ) followed by a 4 week period of "healthy" fructose diet levels (less than 20 grams/day).Baseline measurements and weekly monitoring of somatometry parameters (BMI, %body fat, waist and hip Index, blood pressure), lipid profile and uric acid levels will be done.; patients will receive a normal fructose diet to evaluate possible changes in weight loss after a 6 week period of receiving a caloric intake (proteins, fats and carbohydrates) based on their healthy-desired weight. Participants will be randomized to a 1500, 1800 or 2000 kilocalories diet calculated by Harris Benedict equation, thermic effect of foods and energy (without exercise). Normal fructose arm: participants will receive a 6 week period of normal fructose diet between 50 to 70 grams/day. Baseline measurements and weekly monitoring of somatometry parameters (BMI, %body fat, waist and hip Index, blood pressure), lipid profile and uric acid levels will be done.
Other intervention name(s): NORMAL FRUCTOSE
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Screening
Keywords: Role of Fructose in overweight and obesity; Fructose and metabolic syndrome; Low fructose diet study; Effects of fructose in blood pressure and hypertension; Somatometry changes observed in fructose diets; Fructose induced overweight and obesity; Fructose induced metabolic syndrome; Fructose induced hyperuricemia