Effect of Alpha Hope Dietary Supplement on Health and Cognitive Performance
Condition: Cognitive Change
Study type: Interventional

Summary: 
      The purpose of the present research study is to evaluate the claims about the supplement
      influencing cognitive function that may impact performance on cognitive task and related
      biochemical measures. The synergistic administration of Pyrroloquinoline Quinone and
      molecular Hydrogen (in the form of Alpha Hope) will be evaluated in adults without a
      diagnosis of disease (i.e., otherwise healthy adults-the population the supplement is
      marketed to) on certain biochemical markers, subject's self-assessed wellness, and functional
      measurements determined via computer tests.
    

Detailed description: 
      Alpha Hope is a dietary supplement that contains Pyrroloquinoline Quinone and Magnesium-which
      has been shown to generate molecular hydrogen when mixed into water. Both Pyrroloquinoline
      Quinone and molecular hydrogen have been shown to exhibit antioxidant and anti-inflammatory
      capacities. Both Pyrroloquinoline Quinone and magnesium are widely used as dietary
      supplements, alone and in combination with other ingredients; however, to our knowledge, this
      is the first time that these two ingredients have been coupled together within one dietary
      supplement.

      Previous research has demonstrated a wide range of health benefits from Pyrroloquinoline
      Quinone. Of particular interest, Pyrroloquinoline Quinone has been shown to improve cognition
      when supplemented at daily dosages similar to that proposed in the present study.

      Molecular hydrogen has inherent anti-apoptosis, anti-inflammatory, and anti-oxidation
      properties and has therefore been studied in numerous animal studies, as well as human
      studies as a possible treatment for degenerative brain function. One method for generating
      molecular hydrogen, is using elemental magnesium, which reacts with water to generate
      molecular hydrogen.

      The purpose of the present research study is to evaluate the claims about the supplement
      influencing cognitive function that may impact performance on cognitive task and related
      biochemical measures. The synergistic administration of Pyrroloquinoline Quinone and
      molecular Hydrogen (in the form of Alpha Hope) will be evaluated in adults without a
      diagnosis of disease -(i.e., otherwise healthy adults- the population the supplement is
      marketed to) on certain biochemical markers, subject's self-assessed wellness, and functional
      measurements determined via computer tests.
    

Intervention name(s): Drink
Intervention type(s): Dietary Supplement
Intervention description(s): Consume one tablet fully dissolved in 8 ounces. Take 2 tablets per day for adults (morning and evening) for 4 weeks
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Subjects take randomly assigned condition for 4 weeks, then washout for 3 weeks before crossing over to other condition for 4 weeks.
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: Alpha Hope; Pyrroloquinoline Quinone; Molecular Hydrogen