bioihbjkbjnl/mcl2 huggingface dataset:
Early Prevention of Conduct Problems
Condition: Conduct Disorder
MeSH terms: Conduct Disorder
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to examine the immediate and long-term effects of a prevention
      program in children at risk for developing conduct problems and antisocial behavior.
    

Detailed description: 
      Participants are randomly assigned to a year-long family-based intervention or to a no
      contact control group. The intervention focuses on improving parenting practices,
      parent-child interactions, and child social competence.

      Children are assessed at the beginning of the study and again after one year. The development
      of conduct problems, social competence, and school functioning is assessed from second
      through fifth grade. Assessments are made through observations, parent and teacher ratings,
      and diagnostic interviews.
    

Intervention name(s): Family-Based Preventive Intervention
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Social Behavior Disorders
Motor Imagery for Reach-to-grasp Rehabilitation After Tetraplegia
Condition: Tetraplegia C5-C6; Tetraplegia C6-C7
MeSH terms: Quadriplegia
Study type: Interventional

Summary: 
      Single center, pilot study, to evaluate the influence of Motor Imagery (MI) on functional
      rehabilitation and cerebral plasticity through the qualitative and quantitative mental
      practice approach. For this, the investigators will use magnetoencephalography (MEG) but also
      physiological and behavioral indicators developed by the Laboratoire de la Performance
      Motrice, Mentale et du Matériel (P3M) of Université Claude Bernard Lyon 1 and its partners.
    


Intervention name(s): motor imagery
Intervention type(s): Procedure
Intervention description(s): Intervention consisted of supervised MI during which the participants were trained to imagine performing a single-joint wrist extension movement and a multiple-joint reach-to-grasp movement using tenodesis. The two movements were practiced in separate blocks and each 45 minute MI session consisted of six to eight blocks. Within a given block patients; i) performed the movement once, ii) imagined it using visual imagery (between five and ten repetitions), iii) performed the movement again, and iv) imagined it using kinesthetic imagery (between five and ten repetitions). All movements (performed and imagined) were timed by the experimenter to ensure that the durations of both imagined and physically practiced movements were similar. Imagery vividness was controlled with self-rated assessments using a visual analogic scale (from 0, the image or feeling was absent, to 10 when it was as clear or intense as physical practice).
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Cervical spinal cord injury; Motor imagery; Magnetoencephalography
A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Condition: Worsening Chronic Heart Failure; Chronic Kidney Disease
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic
Study type: Interventional
Phase: Phase 1

Summary: 
      Researchers are looking for a better way to treat people who have worsening of chronic heart
      failure, a long-term condition where the heart does not pump blood as well as it should.

      In this study researchers wanted to learn more about a new substance called finerenone
      (BAY94-8862).

      Finerenone is a substance that blocks the activation of a protein in the body called
      mineralocorticoid receptor (MR). An increased activation of MR is involved in the development
      of hypertension, organ damage and worsening of heart failure. Many patients with worsening
      chronic heart failure also suffer from chronic kidney disease. Chronic kidney disease is a
      long-term decrease in the kidneys' ability to work properly.

      The researchers studied how finerenone moves into, through and out of the body. The
      researchers also looked at how safe finerenone is and how it affects the body. The main
      purpose of this study was to help researchers develop recommendations for the amount of the
      substance (the dosing) to be given to patients with reduced kidney function.
    


Intervention name(s): Finerenone (BAY94-8862)
Intervention type(s): Drug
Intervention description(s): 10 mg BAY94-8862 immediate release (IR) tablet, administered orally
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Hydrogen-rich Water for Non-alchoholic Fatty Liver Disease
Condition: Non-Alcoholic Fatty Liver Disease
MeSH terms: Liver Diseases; Fatty Liver; Non-alcoholic Fatty Liver Disease
Study type: Interventional

Summary: 
      This study evaluates how 4-week supplementation with hydrogen-rich water affects liver fat
      accumulation, blood lipid profiles and body composition in patients with non-alcoholic fatty
      liver disease
    

Detailed description: 
      Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder characterized by liver fat
      deposition due to causes other than excessive alcohol consumption. NAFLD can cause many liver
      dysfunction-related symptoms and signs, with the disease may progress to non-alcoholic
      steatohepatitis, a condition marked by liver inflammation, fibrosis and irreversible damage.
      NAFLD is usually accompanied by insulin resistance and obesity, with up to 30% of population
      in industrialized countries have NAFLD. While NAFLD is rapidly becoming the most common liver
      disease worldwide, its treatment remains elusive, and directed toward correction of the risk
      factors. Since metabolic impairment plays a major role in NAFLD pathogenesis, any agent that
      advance lipid and glucose metabolism could be appropriate to tackle this complex condition.
      Molecular hydrogen (H2) has recently emerged as a novel pro-metabolic agent that might
      positively affect liver health. Supplemental hydrogen improves blood lipid profiles and
      insulin resistance in overweight women, patients with type 2 diabetes, and in subjects with
      potential metabolic syndrome. In addition, drinking hydrogen-rich water reduces hepatic
      oxidative stress and alleviated fatty liver damage in rodents. However, no human studies so
      far evaluated its effectiveness to alter liver steatosis in patients with NAFLD. In this
      pilot trial, we analyze the effects of 4-week hydrogen-rich water intake on liver fat
      deposition, body composition and lab chemistry profiles in overweight patients suffering from
      NAFLD.
    

Intervention name(s): Hydrogen; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Hydrogen-rich water; Tap water
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
High On-treatment Platelet Reactivity Identified by Multiple Platelet Function Assay
Condition: Acute Coronary Syndrome
MeSH terms: Acute Coronary Syndrome
Study type: Interventional

Summary: 
      High on-treatment platelet reactivity to adenosine diphosphate was a important reason to
      cause ischemic events in antiplatelet therapy. Using single testing to definite HPR may miss
      the "true HPR" or over estimate HPR, which may lead to randomized trials failed. It is not
      known whether combined multiple platelet function testing could assist to ensure"ture"HPR and
      improve clinical outcomes.
    

Detailed description: 
      This was a single-center, randomized, prospective study. ACS patients undergoing PCI treated
      with clopidogrel and aspirin were included. in the 3-5th day after prescription of
      clopidogrel, platelet function were tested simultaneously by three methods: MPAADP by Light
      transmittance aggregometry（LTA）, MAADP by Thrombelastography (TEG) ,and CTP2Y by Innovance
      PFA-200 . According to three result（Two of three or all three results higher than cutoff
      value was identified as HPR, MPALTA>50%;MAADP>47mm;CTP2Y<106s）.Patients was defined as
      HPR(n=125) or unHPR(n=232), HPR patients were divided into HPR-Ticagrelor(HPR-T)and
      HPR-Clopidogrel(HPR-C) randomized. HPR-T group(n=77) patients' antiplatelet agents changed to
      ticagrelor, both unHPR and HPR-C groups keep unchanged(Clopidogrel). The major adverse
      cardiovascular events (MACE) were recorded during 1 year Follow-up.
    

Intervention name(s): Clopidogrel; Ticagrelor
Intervention type(s): Drug; Drug
Intervention description(s): Antiplatelet agent; New P2Y12 receptor inhibitor antiplatelet agent
Intervention MeSH terms: Clopidogrel; Ticagrelor
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: clopidogrel；antiplatelet therapy
Distribution of Neutrophils in Bronchial Mucosal Tissue in Asthma Patients Before and After 4 Weeks Treatment With AZD 5069
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 1

Summary: 
      Distribution of neutrophils in bronchial mucosal tissue in asthma patients before and after 4
      wk treatment with AZD 5069
    

Detailed description: 
      The purpose is to investigate the bronchial tissue neutrophil counts and distribution in
      asthma patients after 4 week oral treatment with AZD 5069
    

Intervention name(s): AZD5069
Intervention type(s): Drug
Intervention description(s): oral BD administration of 45 mg AZD5069
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Keywords: Asthma
Treatment of Cervical Syndrome With Myofascial Therapies
Condition: Cervical Syndrome
MeSH terms: Syndrome
Study type: Interventional

Summary: 
      This study aimed to investigate the effects of myofascial release therapy (MRT) for improving
      pressure pain thresholds (PPTs), range of motion and pain in patients with mechanical neck
      pain (NP).
    

Detailed description: 
      Fifty-four participants with NP were randomly allocated to either an MRT (five sessions) or a
      physical therapy (PT) groups (ten sessions) during two weeks. Multimodal PT program included:
      ultrasound therapy (US), transcutaneous electric nerve stimulation (TENS) and massage. Visual
      Analogue Scale (VAS), range of motion and (CROM) PPTs in sub-occipital and upper trapezius
      muscles were measured at baseline, at the end of treatment and at 1 month follow-up. T-tests
      and a repeated-measures multivariate analysis of variance (RM-MANOVA) were used for VAS, CROM
      and PPTs, respectively.
    

Intervention name(s): Physiotherapy treatment; Physiotherapy treatment
Intervention type(s): Procedure; Procedure
Intervention description(s): The MRT group was treated five times with several maneuvers. Each maneuver was performed once per session by slow and progressive application of a light force. The whole procedure lasted no more than 45 minutes. The treatment included four basic maneuvers.
Suboccipital induction
Posterior elongation of the cervical fascia in Supine position
Assisted cervical fascia
Myofascial induction of sternocleidomastoid; The PT group will treated during two weeks (ten days/week) with ultrasound therapy (US), transcutaneous electric nerve stimulation (TENS) and massage, in this order. Ultrasound will applied in pulse mode at an intensity of 1 megahertz for 10 minutes in the sub-occipital region and the vicinity of the trapezius muscles. TENS will applied with a pulse duration of 250 microseconds at a frequency of 80 Hertz for 20 minutes in the sub-occipital region and the trapezoids. Deep massage was applied at a slow speed for 20 minutes using sliding neutral creams. Massage therapy included gliding and kneading techniques applied over trapezius (upper, lower and middle fibers), splenius capitis and levator scapulae muscles with a therapeutic intention.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: RANDOMIZED CLINICAL TRIAL WITH BLIND EVALUATION BY THIRD PARTIES, LONGITUDINAL AND PROSPECTIVE.
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Neck Pain; Physical Therapy Modalities; Fascia; Manual Therapy; Massage
PGT-A in Screening of Embryos in the Treatment of Unexplained Recurrent Miscarriage
Condition: Recurrent Early Pregnancy Loss
MeSH terms: Abortion, Spontaneous; Abortion, Habitual; Recurrence
Study type: Observational

Summary: 
      uRM patients selected PGT-A from 2012 to 2016 were included in this study. Their clinical
      outcomes were prospectively observed and analyzed to explore the factor influenced the
      outcomes.
    

Detailed description: 
      This prospective observational study enrolled all women with uRM who underwent
      array-comparative genomic hybridization (array-CGH) for PGT-A in the Reproductive Medicine
      Center of Peking University Third Hospital from 2012 to 2016. If a couple underwent multiple
      stimulation cycles during the research period, only the first cycle was included. All
      patients underwent adequate clinical and genetic consultations before undergoing PGT-A, and
      all voluntarily chose PGT-A after fully understanding its risks and benefits. All patients
      signed the informed consent document of PGT-A. All included stimulation cycles involved
      intracytoplasmic sperm injection insemination. After successfully fertilized embryos formed
      blastocysts on Day 5-7, trophoblasts were biopsied to determine embryonic karyotypes. The
      blastocysts with normal/balanced test results were cryopreserved, whereas abnormal
      blastocysts were discarded after notifying the patients. All normal blastocysts from a
      patient were thawed and transferred singly, and the outcomes of all subsequent frozen-thawed
      embryo transfer cycles were followed-up until January 2020.

      Clinical outcomes included the blastocyst formation rate, the proportion of blastocysts with
      normal karyotypes, and the clinical pregnancy, live birth, and cumulative live birth rates.
      The factors that affected these clinical outcomes were analyzed to predict outcomes and guide
      treatment in women with uRM.
    

Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        women with uRM who underwent array-comparative genomic hybridization (array-CGH) for PGT-A
        in the Reproductive Medicine Center of Peking University Third Hospital from 2012 to 2016
Interferon Alpha Lozenges Plus Oseltamivir for Influenza Treatment
Condition: Influenza A Virus Infection
MeSH terms: Infections; Influenza, Human
Study type: Interventional
Phase: Phase 2

Summary: 
      This study aims to evaluate the safety and effect of interferon-alpha lozenges when used in
      combination with oseltamivir (Tamiflu) to treat influenza.
    


Intervention name(s): Interferon-alpha; Oseltamivir; maltose
Intervention type(s): Drug; Drug; Other
Intervention description(s): 150 IU lozenges bid for 5 days; 75 mg capsules bid for 5 days; 200 mg maltose lozenges bid for 5 days
Other intervention name(s): IFN lozenge; Tamiflu; placebo
Intervention MeSH terms: Interferons; Interferon-alpha; Oseltamivir
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: interferon-alpha; oseltamivir; drug therapy, combination; influenza; therapies, investigational
Progesterone vs Placebo Therapy for Women With Epilepsy
Condition: Epilepsy
MeSH terms: Epilepsy
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this investigation was to determine if cyclic adjunctive progesterone
      supplement is superior to placebo in the treatment of intractable seizures in women with and
      without catamenial epilepsy.
    

Detailed description: 
      This is a 6-month study. The first 3 months will gather baseline information on seizures,
      antiepileptic drug levels , menstrual cycles, hormone levels, emotional function, and quality
      of life. The second 3 months will assess the effects of treatment on these parameters.
    

Intervention name(s): Progesterone Lozenges; Matched Placebo Lozenges
Intervention type(s): Biological; Other
Intervention description(s): 200mg Progesterone Lozenges; Matched Placebo Lozenges
Intervention MeSH terms: Progesterone
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: This was a phase III, randomized, double-blind, placebo-controlled, multicenter trial. Randomization was carried out separately for women with and without catamenial epilepsy, 2:1 to progesterone or placebo.
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Epilepsy; Seizure; Hormone; Progesterone; Catamenial
A Dose-response Trial Using rFSH FE 999049 in Women Undergoing IVF/ICSI Treatment
Condition: Infertility
MeSH terms: Infertility
Study type: Interventional
Phase: Phase 2

Summary: 
      This trial investigates the effects of several doses of FE 999049 in women undergoing
      IVF/ICSI (in-vitro fertilisation/intracytoplasmic sperm injection) treatment.
    


Intervention name(s): FE 999049; Gonal - F
Intervention type(s): Drug; Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Stereotactic Radiation to Decrease Pancreatic Secretions
Condition: Pancreatic Fistulae
MeSH terms: Pancreatic Fistula; Fistula
Study type: Interventional

Summary: 
      Patients that have undergone pre-operative radiation for pancreatic carcinoma, that upon
      pathologic examination of the normal portion of the pancreatic gland that was in the
      radiation field showed acute and chronic changes in the pancreatic cells. The hypothesis for
      utilizing stereotactic radiation on pancreatic fistulae is that the treatment will decrease
      pancreatic secretions, thus decreasing autodigestion.
    

Detailed description: 
      Stereotactic radiation for cancer has been utilized to successfully treat the head of the
      pancreas, which is generally a well-tolerated procedure with minimal complications. Upon
      further investigation under the microscope, after resection during a complex Whipple
      operation, it is noted that particularly the exocrine glandular tissue atrophied
      substantially. Based on this information, the hypothesis for utilizing stereotactic radiation
      on the remaining pancreas is production of a fibrosis of the pancreas and a decrease in the
      production of exocrine portion of the gland. The use of stereotactic radiation will be
      performed on individuals that are non-surgical candidates.
    

Intervention name(s): Stereotactic Radiation
Intervention type(s): Radiation
Intervention description(s): Treatment of pancreas with 30 Gy of radiation given in 5 fractions of 6 Gy each with stereotactic radiosurgery that could produce a fibrosis of the pancreas and a decrease in the production of exocrine portion of the gland.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Pancreas; Pancreatic fistula; Stereotactic radiation
Nervous System Infections Among Patients With Febrile Seizure
Condition: Seizure; Febrile Seizure; Meningitis; Encephalitis
MeSH terms: Seizures; Meningitis; Encephalitis; Seizures, Febrile; Hyperthermia; Fever
Study type: Observational

Summary: 
      Few studies dealing with the risk of infectious of nervous system and the utility of lumbar
      puncture and of emergent neuroimaging among patients with simple febrile seizure between 3
      and 11 months age and with complex seizure has been reported. None of these studies was
      multicentric. Recommendations about management of these children are heterogeneous.

      The investigators aim to study by an observational retrospective multicentric study the rate
      of infectious of central nervous system among patients with a complex febrile seizure and
      among patients between 3 and 11 months age with simple febrile seizure.
    


Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        This was a retrospective cohort review of consecutive patients admitted in 7 pediatric
        emergency departments in Ile-de-France between 2007 and 2011. All clinically well-apparent
        children 3 to 11 months of age with a first simple febrile seizure were included in the
        study. All children between 3 months and 5 years with a complex febrile seizure were
        included
Post-traumatic Stress Disorder Treatment Using Transcranial Direct Current Stimulation (tDCS) Enhancement of Trauma-focused Therapy : a Two-arm Randomized Controlled Multicentric Study.
Condition: Post-traumatic Stress Disorder
MeSH terms: Stress Disorders, Traumatic; Stress Disorders, Post-Traumatic
Study type: Interventional

Summary: 
      Post-Traumatic Stress Disorder (PTSD) is an anxiety disorder that can develop after exposure
      to a terrifying event or ordeal in which there was the potential for or actual occurrence of
      grave physical harm. Traumatic events that may trigger PTSD include violent personal
      assaults, natural or human-caused disasters, accidents, and military combat. People with PTSD
      have persistent frightening thoughts and memories of their ordeal, may experience sleep
      problems, feel detached or numb, or be easily startled. Its lifetime prevalence is quite
      high, with 7-8% in various studies and 4% in french studies.

      The current PTSD treatment usually involves antidepressants as serotonin-specific reuptake
      inhibitors (SSRIs) and Cognitive Behavioral Therapies, such as exposure therapy to
      trauma-linked elements (memories, feelings and thoughts) so the fear associated to the
      traumatic event can decrease. But the therapeutic response stays partial, even combining
      these treatments.

      To improve the PTSD treatment efficiency, innovative approaches are being explored like new
      drugs or cerebral stimulation. This project aims to assess the efficacy of a less known but
      promising therapeutic strategy for PTSD : the use of transcranial Direct-Current Stimulation
      (tDCS) to enhance the trauma-focused therapy results.
    


Intervention name(s): tDCS; Placebo tDCS
Intervention type(s): Device; Device
Intervention description(s): tDCS for transcranial Direct-Current Stimulation; Placebo tDCS for transcranial Direct-Current Stimulation
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Study of Psychiatric Aspects in Women With Lower Urinary Tract Symptoms
Condition: Psychiatric Aspects in Women With Lower Urinary Tract Symptoms
MeSH terms: Lower Urinary Tract Symptoms
Study type: Observational

Summary: 
      To identify the differences in psychopathology, personality traits among different female
      LUTS subtypes.
    


Intervention name(s): No drug
Intervention type(s): Other
Intervention description(s): Psychopathology, personality traits of patients with lower urinary tract symptoms
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients with low urinary tract symptoms