SATIN: Satiety Innovation. Study 2- University of Aberdeen
Condition: Overweight and Obesity
MeSH terms: Obesity; Overweight
Study type: Interventional

Summary: 
      The proposed study will address the effect of developed novel food products through
      processing innovation on motivation to eat, biomarkers of satiety, nutrient bioavailability
      and gut health using in vivo studies and validating new in vivo approaches.

      Specifically in this protocol the investigators will address, in a short human intervention
      study the effect of a potentially satiating product on appetite, appetite biomarkers,
      particularly the influence on gut microbiota, tolerance and safety of the products in healthy
      obese and overweight participants in free living conditions.
    

Detailed description: 
      Previous research has suggested that food structure and food composition has a role to play
      in controlling consumption. Low-energy, high-fibre diets provide physical bulk in the
      gastro-intestinal tract to sustain fullness in a way that low-volume, energy-dense foods
      cannot. However, studies shown low long term acceptability be probably associated to its poor
      palatability. Taste and hedonic experience remain the main drivers of consumer choice, and
      the immediate sensory aspect of food products such as palatability to have greater salience
      to consumers than their health promoting properties.

      Changing the properties of foods merely by changing oro-sensory properties and through the
      delay of gastric emptying deals with mechanisms critical to within-meal satiation and early
      post meal satiety and may produce only transient suppression of hunger unless regularly
      consumed and represent benefits in delivering nutritional stimuli to key parts of the
      gastro-intestinal tract. The potential to manufacture change can make food structure variety
      now seem near limitless due the numerous advances in food technology.

      Several recent reports have associated satiety effects with fermentable fibre sources in
      human dietary studies. Apparently, the large intestine microbiota recovers 'extra' calories
      from the diet and might contributes to obesity. However, the different mechanisms involved in
      lean and obese subjects are not completely resolved. Recent evidence in experimental animal
      designs indicates that changes in gut microbiota composition may be associated with increased
      food intake and obesity suggesting that satiety and intake are influenced by the species
      composition of the gut microbiota.

      This short-term human nutrition study comprises in a randomised, cross-over design testing
      either two potentially satiety product, Arabinoxylan (A) or Beta-glucan (B) against an
      equivalent amount of heterogeneous natural fibre (Control) in 40 healthy-obese volunteers,
      aged 18-65 years old, BMI between 27 and 42Kg/m2 from both genders after an initial
      maintenance diet in free- living conditions.

      Dietary intake, body weight, blood pressure would be monitored through the study. Faecal,
      urine and blood samples will be collected to monitor, glucose, insulin, gut peptides and
      assess metabolites of dietary and microbial origin. Orocecal Transit Time (OCTT),
      carbohydrate fermentability and methanogen status will be estimated using a breath test and
      transit time will be determined using SmartPill™.
    

Intervention name(s): Arabinoxylan; Beta- Glucan
Intervention type(s): Other; Other
Intervention description(s): 10 days of weight loss diet calculated as 100% RMR + 15g Arabinoxylan (Medium Chain Naxus, BioActor b.v., Netherlands) per day in incremental dose 25% according energy requirement, 30% protein, 30% fat, 40% carbohydrate.; 10 days of weight loss diet calculated as 100% RMR + 6g β-glucan (Viscofibre, Naturex SA, France) per day in incremental dose 25% according energy requirement, 30% protein, 30% fat, 40%
Other intervention name(s): MC- NAXUS; Viscofiber
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: Overweight and Obesity; Appetite; Gut hormones and obesity; Arabinoxylan, Beta-Glucan; SmartPill