bioihbjkbjnl/mcl2 huggingface dataset:
Comparision Of The Effectiveness Of Physiotherapy Methods
Condition: Cerebral Palsy
MeSH terms: Cerebral Palsy
Study type: Interventional

Summary: 
      A total of 28 patients who were followed-up in our clinic and received botulinum toxin
      injection of lower extremities in the last month were randomized to two groups in the study.
      Group 1 received conventional physiotherapy and Group 2 received robot-assisted gait
      training. The treatment period was 30 min/day, five sessions in a week, 15 sessions in total,
      for both groups. The study population was evaluated using range of joint motion evaluation
      chart, the Modified Ashworth Scale, The Gross Motor Function Classification System, The Berg
      Balance Scale, the functional independence measure for children, and the Edinburgh Visual
      Gait Score
    

Detailed description: 
      A total of 28 patients who were followed-up in our clinic and received botulinum toxin
      injection of lower extremities in the last month were randomized to two groups in the study.
      Group 1 received conventional physiotherapy and Group 2 received robot-assisted gait
      training. The treatment period was 30 min/day, five sessions in a week, 15 sessions in total,
      for both groups. The study population was evaluated using range of joint motion evaluation
      chart, the Modified Ashworth Scale, The Gross Motor Function Classification System, The Berg
      Balance Scale, the functional independence measure for children, and the Edinburgh Visual
      Gait Score.
    

Intervention name(s): ROM exercises, stretching, positioning, gait training; by two physiotherapist under the supervision of a doctor
Intervention type(s): Procedure; Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A total of 28 patients who were followed-up in our clinic and received botulinum toxin injection of lower extremities in the last month were randomized to two groups in the study. Group 1 received conventional physiotherapy and Group 2 received robot-assisted gait training.
Masking: Single (Participant)
Primary purpose: Health Services Research
Keywords: Botulinum-toxin, cerebral-palsy, robot-assisted therapy
Switching From Oral Antipsychotics to Long-Acting Risperidone in Participants With Schizophrenia
Condition: Schizophrenia
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to evaluate efficacy, safety and tolerance of long-acting
      risperidone when switching from oral antipsychotics in participants with schizophrenia
      (psychiatric disorder with symptoms of emotional instability, detachment from reality, often
      with delusions and hallucinations, and withdrawal into the self).
    

Detailed description: 
      This is an open-label (all people know the identity of the intervention), multi-centric
      (conducted in more than one center) and non-comparative study of long-acting risperidone in
      participants with schizophrenia who have a previous history (in the last 12 months) of bad
      adherence to the oral antipsychotic treatment of first or second generation. The duration of
      this study will be 24 weeks and will include following visits: Screening, Baseline, Week 2,
      4, 8, 12, 16, 20, 24, 38 and 50 (End visit or early withdrawal). All the eligible
      participants (after risperidone intolerance test during screening) will receive a dose of 25
      milligram risperidone every two weeks by intramuscular injection (injection of a substance
      into a muscle). Efficacy and safety of the participants will primarily be evaluated by
      Positive and Negative Syndromes Scale and Extrapyramidal Symptom Rating Scale, respectively.
      Participants' safety will be monitored throughout the study.
    

Intervention name(s): Risperidone prolonged release
Intervention type(s): Drug
Intervention description(s): Risperidone will be administered as intramuscular injection as 25 milligram (mg) every two weeks, from Week 1 to 50, wherein after Week 3, dose may be adjusted up to 50 mg at physician criterion. For first two weeks, previous oral antipsychotic drug will be maintained and the dose will be gradually decreased and will cease at Week 3.
Other intervention name(s): - Risperdal consta
Intervention MeSH terms: Risperidone
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Schizophrenia; Risperidone; Risperdal consta
Sevice-learning in Physiotherapy and Heart Transplantation and Acute Coronary Syndrome
Condition: Heart Transplantation
MeSH terms: Acute Coronary Syndrome
Study type: Interventional

Summary: 
      A service-learning programme in physiotherapy students will be performed. 30 physiotherapy
      students will be randomly assigned to an intervention group (n=16) or to a control group
      (n=16). Intervention group will perform a service-learning program with real patients with
      heart transplantation, and will have to perform a physical therapy program adapted to a real
      patient. Two meetings will be performed in order to establish groups, explain the project and
      search information based on evidence in scientific databases. In addition, three meetings
      with patients will be stated in order to establish the adapted program based on the real
      patient's needs and characteristics. The control group will have to perform a physiotherapy
      program without meeting real patients.
    

Detailed description: 
      This study aims at determining the effect of a Service-Learning program on knowledge, ethical
      sensitivity and acquired transversal competences. On the other hand, we aim at evaluating the
      service performed, the skills acquired, the participation, the degree of participatory
      evaluation and the level of satisfaction of the intervention group. All variables will be
      measured with validated scales or questionnaires.

      Both groups will have to describe the specific characteristics of the program, different
      phases of the process, types of exercises recommended, contraindications, safety ranges with
      respect to the intensity of the exercise, ways of calculating the intensity and self-control.
      Likewise, they will have to defend the usefulness and duration of the final product through
      an oral presentation of the program to the patients themselves. Finally, the possible doubts
      that should exist will be solved.
    

Intervention name(s): Service-learning program
Intervention type(s): Other
Intervention description(s): Intervention group will perform a service-learning program with real patients with heart transplantation, and will have to perform a physical therapy program adapted to a real patient. Two meetings will be performed in order to establish groups, explain the project and search information based on evidence in scientific databases. In addition, three meetings with patients will be stated in order to establish the adapted program based on the real patient's needs and characteristics.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Characterization of a Clinical Subpopulation With Autism Spectrum Disorder
Condition: Autism Spectrum Disorder
MeSH terms: Autistic Disorder; Autism Spectrum Disorder; Child Development Disorders, Pervasive
Study type: Observational

Summary: 
      The main objective for this research study is to gather additional information to help
      confirm identification of new subgroups within the autism spectrum.
    


Intervention name(s): Observation
Intervention type(s): Other
Intervention description(s): Clinical signs and symptoms
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Cincinnati Children's Hospital Primary Care Clinic
Study to Evaluate the Safety, Tolerability and Pharmacokinetics of PBTZ169 in Multiple Dosing
Condition: Tuberculosis, Pulmonary
MeSH terms: Tuberculosis; Tuberculosis, Pulmonary
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a randomized, double-blind, placebo-controlled, multiple ascending dose study
      conducted at one study center in Switzerland.

      Four (4) panels (A, B, C and D) of 8 male subjects (6 active and 2 placebo) each receiving
      multiple doses of PBTZ169 or a matching placebo, at increasing dose levels, once or twice
      daily.

      Subjects will participate in only one panel. Blocks of 4 subjects (3 under active treatment,
      1 under placebo) will be investigated in parallel. Panels will start sequentially.

      Safety will be assessed throughout the study; serial ECGs and serial blood samples will be
      collected for the safety and PK assessment of PBTZ169.

      Dose escalation will be allowed once the Trial Safety Board has determined that adequate
      safety and tolerability after each panel completion has been demonstrated to permit
      proceeding to the next panel.

      In addition, a preliminary assessment of the drug interaction potential of PBTZ169 will be
      done by the measurement of inhibition or induction of human cytochromes through the
      metabolism of microdoses of standard probe substrates
    


Intervention name(s): PBTZ169; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): PBTZ169 crystalline supplied as powder for oral solution; matching placebo supplied as powder for oral solution
Intervention MeSH terms: Macozinone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Immunization of Children Previously Primed With GSK Pneumococcal Vaccine GSK1024850A and of Unprimed Children in Mali
Condition: Infections, Streptococcal
MeSH terms: Streptococcal Infections
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this trial is to assess the safety, reactogenicity and immunogenicity of GSK
      Biologicals' pneumococcal conjugate vaccine GSK1024850A when administered either as a booster
      dose or as a two dose catch-up vaccination in the second year of life to the Malian subjects
      previously enrolled in the primary vaccination study NCT00678301.

      This protocol posting deals with objectives & outcome measures of the booster phase. The
      objectives & outcome measures of the primary phase are presented in a separate protocol
      posting (NCT number = NCT00678301).
    


Intervention name(s): Pneumococcal vaccine GSK1024850A
Intervention type(s): Biological
Intervention description(s): Intramuscular injection, 1 or 2 doses
Intervention MeSH terms: Heptavalent Pneumococcal Conjugate Vaccine
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Booster vaccination; Pneumococcal vaccine; Catch-up vaccination; Pneumococcal disease; Safety; Immunogenicity
Pre-ERCP High Carbohydrate Drinks Improve Patients Recovery
Condition: Complication
Study type: Interventional

Summary: 
      To test the benefits of extra high carbohydrate liquid diet uptake 2 hours before ERCP in
      improving patients' early recovery.
    

Detailed description: 
      Enhanced recovery after surgery (ERAS) has been formed of procedure which contains
      preoperative education, improvement of anesthesia, reducing the number of drainage tubes, and
      early diet after surgery. In recent years, because of its positive advantages, ERAS was
      widely accepted in surgical fields.

      For upper gastrointestinal surgery, high-carbohydrate drinks can be given 2 hours before
      surgery in order to guarantee the stability of blood glucose and circulation during the
      operation. It obviously reduce the preoperative thirst, hunger, irritability and even the
      incidence of postoperative complications.

      However ERAS program is rarely studied in ERCP. Theoretically we can use ERAS as a strategy
      to reduce post-ERCP uncomfortable and complications.
    

Intervention name(s): 400ml high carbohydrate liquid diet before ERCP
Intervention type(s): Procedure
Intervention description(s): 400ml high carbohydrate liquid diet uptake 2 hours before ERCP
Other intervention name(s): Routine ERCP
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: ERCP; ERAS; complication; fatigue; high carbohydrate diet
Evaluation Of Safety, Tolerability And Pharmacokinetics Of Single And Multiple Doses Of Compound PF-06823859
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine the safety, tolerability and pharmacokinetics of
      escalating single and multiple intravenous (IV) infusions and subcutaneous (SC) injections of
      PF 06823859 in healthy subjects.
    


Intervention name(s): PF-06823859; Placebo injection SC/IV
Intervention type(s): Biological; Drug
Intervention description(s): Comparison of different dosages of PF-06823859 to placebo; Comparison of Placebo to different doses of PF-06823859
Other intervention name(s): Study drug; Placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: First in human, Phase 1, Healthy volunteers
A Comparative Analysis of Two Types of Exercise on Outcomes Following Total Knee Arthroplasty
Condition: Osteoarthritis, Knee
MeSH terms: Osteoarthritis, Knee
Study type: Interventional

Summary: 
      The purpose of this study was to compare the effects of two exercise programs, using low
      velocity (LV) and high velocity (HV) contractions, on outcomes of individuals who have
      undergone total knee arthroplasty (TKA). The experimental hypothesis was that individuals
      performing HV exercise, compared to LV, would exhibit superior outcomes.
    

Detailed description: 
      The most effective type of exercise has not been identified for individuals who undergo total
      knee arthroplasty (TKA). High velocity (HV) exercise when compared to low velocity (LV)
      exercise produces greater gains in power and certain functional activities in older adults.
      The use of HV exercise for patients who undergo TKA has not been investigated.
    

Intervention name(s): Exercise
Intervention type(s): Behavioral
Intervention description(s): Participants attended standardized exercise (ex) sessions twice a week for six weeks for 12 sessions. Group speed differed for concentric contractions, sit to stand ex, walking, curbs, and stairs. The low velocity ex group performed a concentric contraction in two seconds, and high velocity group in one second or less. End range concentric hold, eccentric contraction, repetition (rep) rest and set rest were the same. Open chain ex was performed at 50% of one Repetition Maximum (RM) x 10 reps x one set and then 80% of 1RM x 10 reps x two sets. Curb height and 1RM was assessed at the first, fifth and ninth sessions. Manual stretching, balance ex, sit to stand support, level of aerobic ex, gait training, and functional training were assessed and progressed at any session.
Other intervention name(s): Rehabilitation
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Joint Replacement; Exercise; Power training
Video Versus Conversational Contraceptive Counseling During Maternity Hospitalization
Condition: Contraceptive Usage; Contraception Behavior
Study type: Interventional

Summary: 
      A randomized trial comparing LARC uptake and satisfaction after either video or
      conversational-based contraceptive counseling for pregnant women in labor.
    

Detailed description: 
      This was a multi-center randomized, controlled trial examining contraceptive counseling in
      the setting of long-acting reversible contraception (LARC) uptake and immediate provision. At
      two urban public hospitals with large adolescent populations, participants were randomized to
      a structured, in-person conversation with a trained counselor or a 14-minute video providing
      the same information. Both participant groups were provided written materials and both had
      the opportunity to ask questions of the counselor. The total time to complete counseling was
      measured, as well as participant satisfaction, pre- and post-intervention contraceptive
      knowledge, and intended postpartum contraceptive method.
    

Intervention name(s): Video counseling; Conversational counseling
Intervention type(s): Other; Other
Intervention description(s): Video counseling; Conversational counseling
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Two groups randomized to counseling type.
Masking: None (Open Label)
Primary purpose: Prevention
Randomized Study Comparing Tamoxifen vs. Tamoxifen + Aminoglutethimide in Postmenopausal Receptor-positive Patients
Condition: Early-stage Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Interventional
Phase: Phase 3

Summary: 
      Primarily, this clinical investigation compared the efficacy of tamoxifen + aminoglutethimide
      vs. tamoxifen alone in terms of prognosis (overall survival) in postmenopausal patients with
      potentially curative, operated hormone receptor-positive breast cancer.
    


Intervention name(s): Tamoxifen alone; Tamoxifen + Aminoglutethimide
Intervention type(s): Drug; Drug
Intervention description(s): 2 x 20 mg tamoxifen daily, start of therapy within 4 weeks after surgery; therapy duration 5 years; 2 x 20 mg tamoxifen daily (5 years) plus Aminoglutethimide daily (first 2 years)
1st therapy week:125mg/-/125mg Aminoglutethimide daily
2nd therapy week: 125mg/-/250mg Aminoglutethimid daily
as of 3rd therapy week: 250mg/-/250mg Aminoglutethimid daily
Other intervention name(s): Nolvadex; Nolvadex + Orimeten
Intervention MeSH terms: Tamoxifen; Aminoglutethimide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Tamoxifen; Aminoglutethimide; Breast cancer
Arm Swing During Walking in Early Multiple Sclerosis
Condition: Multiple Sclerosis; Upper Extremity Problem; Gait Disorders, Neurologic
MeSH terms: Multiple Sclerosis; Nervous System Diseases; Gait Disorders, Neurologic; Sclerosis
Study type: Observational

Summary: 
      Multiple sclerosis (MS) is the most common central nervous system inflammatory demyelinating
      disease which causes motor and sensory deficits, cerebellar symptoms, and balance problems.
      Due to these symptoms, gait abnormalities are common in MS, even in patients with low degrees
      of impairment. The upper limb has an important role on postural control and gait stability.
      Affected arm swing movement and asymmetry during gait are common in neurological disorders
      such as Parkinson's disease (PD) even in early stages of the disease and arm swing treatment
      has been acknowledged to enhance gait and normalize arm swing in individuals with PD.

      The presence of arm swing changes during walking in MS patients, similar to PD, especially in
      the early period, may be an indicator of balance problems, this was, however, not
      investigated as such. Therefore, the aim of the current study is to assess the arm swing
      during gait in people with MS shortly after their diagnosis in early MS.
    


Intervention name(s): Evaluation of the arm swing during gait; Functional Tests
Intervention type(s): Other; Other
Intervention description(s): Evaluation of the arm swing during gait: The difference between the maximum flexion and extension of the shoulder is the arm swing amplitude during walking. The arm swing amplitude will be evaluated 2-dimensionally with the help of the Kinovea video player.; To understand the changes in functional mobility, Two Minute Walk Test (2MWT), Timed Up and Go (TUG) and Timed 25Foot Walk Test (T25FW) were conducted.
Other intervention name(s): Arm swing during walking; Two Minute Walk Test (2MWT), Timed Up and Go (TUG) and Timed 25Foot Walk Test (T25FW)
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Eighteen MS outpatients from a hospital and 10 healthy controls were included. The patients
        who were diagnosed with MS in the last 30 days, were recovered from their symptoms and were
        clinically stable were included.

        Patients who had an acute medical illness in the past 6 months, any other neurological and
        psychiatric diseases, and any orthopedic, rheumatologic, or vestibular conditions that
        affect walking were excluded. The patients who had exacerbations between the first and
        second evaluations (three months after the first evaluation) were excluded.
      
Keywords: arm swing, multiple sclerosis, gait, foot pressure analysis
Kinesio Taping Versus Oromotor Training on Drooling in Children With Spastic Cerebral Palsy
Condition: Drooling; Kinesiotape; Cerebral Palsy
MeSH terms: Sialorrhea; Cerebral Palsy
Study type: Interventional

Summary: 
      Statement of the problem :

      Which is more effective for treatment of drooling in children with spastic cerebral palsy;
      kinesio taping or oromotor training?

      Null Hypothesis:

      There will be no difference between the effectiveness of kinesio taping and oromotor training
      on drooling in children with spastic cp.
    

Detailed description: 
      Subjects:

      The Study targets the children with spastic cerebral palsy from both sexes , sample size
      estimation will be carried out to determine the recruited number of children ,Children
      participating in this study will be selected randomly from Cairo pediatric physical therapy
      centers to participate in this study.

      Study Design:

      A comparative experimental design (Prospective pre-test post-test design with 2 months
      follow-up evaluation) .

      Children will be assessed by measuring the drooling before and after two months of receiving
      intervention.
    

Intervention name(s): KINESIOTAPE; oromotor training
Intervention type(s): Other; Other
Intervention description(s): kinesiotape will be applied on orbicularis oris muscle; selected oromotor training: Perioral sensory stimulation ,Tapping,Tongue pressure,Jaw exercises andIntraoral stimulation
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 2
Masking: Single (Participant)
Primary purpose: Treatment