Efficacy of Personalized Exercise Program and Trimetazidine in Rehabilitation of Patients After RFA of AF
Condition: Atrial Fibrillation Paroxysmal
MeSH terms: Atrial Fibrillation
Study type: Interventional

Summary: 
      Atrial fibrillation (AF) is one of the most common forms of heart rhythm disorder in patients
      with cardiovascular diseases. The choice of treatment for AF is a complex problem, depending
      on the form (paroxysmal, persistent, permanent) of AF, clinical manifestations of cardiac
      arrhythmias, associated diseases, the effectiveness of antiarrhythmic drugs. The accumulated
      data to date indicate an efficacy of the method of radiofrequency ablation (RFA) in the
      treatment of the paroxysmal form of AF. The RFA procedure does not eliminate the pathological
      processes that take place during developed AF. This dictates the need to develop and test new
      technologies and physical rehabilitation programmes for patients. The positive clinical
      effects of physical rehabilitation programmes based on moderate-intensity exercises are well
      known. The search for drugs capable of improving the results of RFA for AF in patients
      becomes urgent. This creates the prerequisites for the study of the clinical efficacy of
      trimetazidine MV in the rehabilitation of patients with cardiac diseases who underwent
      treatment of AF with RFA, which will optimize the management of such patients in the
      inpatient and outpatient setting.
    

Detailed description: 
      The study is interventional (Clinical Trial), randomized in parallel groups. Enrollment: 72
      participants.

      The 72 male patients were randomized in 3 groups. In 1st group (control) patients were taken
      antiarrhythmical drugs and anticoagulants. They did only usual activity without walking.
      Patients in 2nd group were taken antiarrhythmical drugs and anticoagulants, participated in
      rehabilitation programme. Twice a week they came in clinical center to engage in physical
      training with an instructor. The programe was lasted for 6 months. Also patients did they
      usual physical activity, practiced walking. Patients in 3rd group were taken antiarrhythmical
      drugs and anticoagulants, selective inhibitor of fat acids oxidation for 6 months. They did
      only usual activity without walking.

      The examination was carried for all 72 patients. Before RFA patients took blood tests,
      performed echocardiography, completed psychological questionnaires. After 3 days they took
      blood tests, performed 6-minute walk testing, ECG monitoring, completed psychological
      questionnaires. One month after RFA patient performed veloergometry testing. Three months
      after RFA the performed 6-minute walk testing, ECG monitoring, took blood tests, completed
      psychological questionnaires. Six months after RFA patients took blood tests, performed
      echocardiography, 6-minute walk testing, ECG monitoring, veloergometry testing, completed
      psychological questionnaires. Onward was a follow up period for 6 months. At the time point
      of 12 months patients took blood tests, performed echocardiography, ECG monitoring,
      veloergometry testing, completed psychological questionnaires.
    

Intervention name(s): Physical training program; Trimetazidine
Intervention type(s): Other; Drug
Other intervention name(s): fatty acids beta-oxidation inhibitor
Intervention MeSH terms: Trimetazidine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: rehabilitation; atrial fibrillation; physical training; radiofrequency ablation