Effects of Protein Hydrolysate Supplementation Influencing Strength Recovery and Expression of Muscle Damage Markers Post-exercise
Condition: Muscle Injury
Study type: Interventional

Summary: 
      A randomised placebo controlled, double-blind, 30 Volunteer trial of Elio™ administered 2.4
      grams per day in assessing its effects on post-exercise strength recovery and increases in
      markers associated with muscle injury and exertion.
    

Detailed description: 
      Periods of intense physical activity and exertion can lead to disruption of normal muscle
      homeostasis and the resultant muscle injury and recovery can impact upon quality of life
      especially in adult populations. Recovery post-exercise is therefore important to all active
      people.

      There is a link between high-intensity exercise and reduced power and performance in the
      following exercise sessions. The effect on performance is measures as a reduced muscle force
      production or loss in strength and can correlate with delayed onset muscle soreness (DOMS).
      The reduced power/performance seen 24 hours - 7days post-exercise is affected by recovery
      methods applied, individual fitness levels and intensity of exercise injury.

      Several theories have been proposed to explain the mechanisms underlying DOMS. These include
      inflammation and muscle damage.

      Exercise-induced muscle damage is a transient phenomenon caused by unfamiliar, damaging
      exercise and is characterized by structural damage to myofibers and secondary inflammation.
      Signs and symptoms often persist for several days after exercise and typically include muscle
      soreness, elevated blood levels of intramuscular enzymes such as creatine kinase (CK),
      lactate dehydrogenase (LDH) and myoglobin (MB) that often result in elevations in circulating
      markers of inflammation such as C-reactive protein (CRP) and various interleukins. To date,
      extensive research has been published that explore the many recovery strategies purported to
      minimize indirect markers of muscle damage.

      However, from a nutritional standpoint the results are weak. It is therefore important to
      develop nutritional products that can lessen the impact of these injuries' individuals
      succumb to or expedite their recovery.

      Nutritional recovery strategies purported to minimise indirect markers of muscle damage and
      improve the inflammatory response can positively influence the recovery process after
      damaging exercise.

      These strategies could in turn be used to prime the muscle for physical challenges.

      Furthermore, there is a clear absence of natural approaches with proven evidence to address
      DOMS and the resulting performance declines.

      Therapies such as non-steroidal anti-inflammatory drugs (NSAIDs) can be taken in the short
      term to reduce DOMS associated pain and inflammation. However, these drugs do not address
      performance strength loss linked to DOMS.

      Acute injuries to discrete muscle groups can be indirectly detected by an array of systemic
      biomarkers, which become elevated at various time-points following the event.

      This array of biomarkers represents key biochemical processes in muscle homeostasis, cellular
      integrity, mitochondrial function and inflammation.

      Preliminary investigations in vitro and in vivo suggest that the administration of peptides
      isolated from the protein extract of fava beans, which constitute Elio™, can augment muscle
      protein synthesis (i.e. phospo-S6) and attenuate proteolytic signaling (i.e. Fbxo32 and
      Trim63) and surrogate inflammatory markers (TNFα and IL6). Thus, supporting the use of this
      hydrolysate in maintaining muscle homeostasis and function.

      With the present study the investigators will investigate whether daily dietary
      supplementation of Elio™, over the course of 15 days can prime the muscle by improving
      strength recovery and attenuating the expression of systemic markers associated with muscle
      injury and over exertion following resistance type exercise in a healthy male population.

      Objectives

      To determine the effect of Elio™ supplementation, a protein hydrolysate derived from fava
      bean protein extract, on strength recovery and markers of muscle health, injury and function
      following strenuous resistance type exercise in male volunteers, aged between 30 and 45 years
      old following 17 days of supplementation.
    

Intervention name(s): Elio; SMCC
Intervention type(s): Dietary Supplement; Other
Intervention description(s): Elio™ supplementation, a protein hydrolysate derived from fava bean protein extract; Placebo comparator
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Prevention
Keywords: muscle; function; markers; resistance; exercise; protein; hydrolysate; supplement; Elio