Effects of Fibromyalgia Syndrome in Patients With Systemic Sclerosis
Condition: Systemic Sclerosis; Fibromyalgia
MeSH terms: Fibromyalgia; Myofascial Pain Syndromes; Scleroderma, Systemic; Scleroderma, Diffuse; Sclerosis
Study type: Observational

Summary: 
      Systemic sclerosis [SSc]; is a multisystem disease characterized by immune activation,
      microvascular disease and fibroblast dysfunction, which is thought to occur as a result of
      complex and not fully understood interaction between genetic and environmental factors,
      leading to fibrotic changes in the skin and some internal organs. It is characterized by the
      deposition of collagen and other matrix components in the skin and some internal organs. It
      has been shown by evaluating the health assessment questionnaire that it causes disability
      with increasing frequency over time.

      Although pain cannot be localized too well to be attributed to a particular anatomical area,
      there are several musculoskeletal pain syndromes that can be detected in patients with
      systemic sclerosis. These are tendonitis, polyarthritis, rheumatoid arthritis, bursitis and
      fibromyalgia. While there are several studies on others, the relationship between
      fibromyalgia syndrome and SSc is not known clearly. As with other connective tissue diseases,
      fibromyalgia is not considered to be rare in SSc.
    

Detailed description: 
      There are a few studies on this subject. Except for one of these studies, the sensitive point
      in ACR 1990 FMS diagnostic criteria set was evaluated. In 2010, ACR published new criteria,
      which may be an alternative method in clinical practice, without sensitive points, including
      the common pain index and symptom severity scale. It is evaluated with the common pain index
      and symptom severity scale. This new set of criteria alone is not affected by pain, it is
      based on patient reporting. Therefore, it seems clinically more significant in determining
      the origin of pain in autoimmune diseases. There was only one study in the literature in
      which SSc patients are evaluated with the 2010 FMS criteria set . Therefore, the aim of our
      study was to evaluate the frequency of FMS according to 2010 FMS criteria and to investigate
      its effect on quality of life in our study.
    

Intervention name(s): Fibromyalgia diagnosis in patients with SSc
Intervention type(s): Diagnostic Test
Intervention description(s): American College of Rheumatology (ACR) FMS diagnostic criteria set:It is evaluated by the common pain index [WPI] and symptom severity (SS) scale [19]. Diffuse pain index [WPI]; It is a scale that can be scored between 0-19 and obtained by indicating the aching regions of the patient during the last 1 week. Right shoulder, left shoulder, right hip [gluteal region], left hip [gluteal region], left chin, right chin, left upper arm, left lower arm, right upper arm, right lower arm, left upper leg, left lower leg, includes right upper leg, right lower leg, chest, neck, abdomen, upper back, lower back. Symptom Severity Scale [SSS]; evaluates weakness, tired awakening and cognitive functions. In addition, muscle pain, weakness, irritable bowel syndrome, memory problems, headache, abdominal pain, numbness, dizziness, insomnia, depression, constipation, irritability, dry mouth etc. It also evaluates somatic symptoms.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Systemic Sclerosis
      
Keywords: fibromyalgia; systemic sclerosis; quality of life