bioihbjkbjnl/mcl2 huggingface dataset:
The Effectiveness of Temporomandibular Joint Mobilization and Exercise in Individuals With Chronic Neck Pain
Condition: Temporomandibular Joint Disorders; Temporomandibular Joint Dysfunction Syndrome; Neck Pain; Chronic Pain
MeSH terms: Joint Diseases; Temporomandibular Joint Disorders; Temporomandibular Joint Dysfunction Syndrome; Chronic Pain; Neck Pain
Study type: Interventional

Summary: 
      To examine the effects of temporomandibular joint mobilization and exercises added to the
      conventional physiotherapy program on posture, functionality and muscular endurance in
      individuals with chronic neck pain.
    

Detailed description: 
      Our research is a randomized controlled trial. 50 participants will be included in the study,
      which will be conducted on individuals aged 18-65 years with chronic neck pain. Participants
      will be divided into 2 groups as experimental and control groups by simple randomization
      method. All patients will be treated with conventional physiotherapy methods for 4 weeks and
      5 days a week. In addition to conventional treatment, temporomandibular joint mobilization
      techniques were applied to the experimental group; exercises will be given. In the study,
      temporomandibular dysfunction (TMD) Pain Screener, Neck Disability Index, and Visual Analog
      Scale questionnaires will be applied to the patients twice, before and after the treatment.
      Before and after the treatment, the cervical region's range of motion and muscular endurance
      will be measured by the physiotherapist. Pre- and post-intervention data were statistically
      analyzed and compared.
    

Intervention name(s): physiotherapy; TMJ exercises
Intervention type(s): Other; Other
Intervention description(s): ultrasound hotpack electrotherapy joint range of motion exercises isometric neck exercises stretching exercises; tongue relaxation position TMJ isometric strengthening exercises Posture exercises Isometric neck extension in neutral position back extension Strengthening the abdominal muscles Supine dorsal stretch pectoral stretch
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: temporomandibular joint mobilization and temporomandibular joint exercises
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: endurance; functionality; joint range of motion
Safety Study in Outpatient Japanese Children With ADHD
Condition: Attention Deficit Hyperactivity Disorder
MeSH terms: Hyperkinesis; Attention Deficit Disorder with Hyperactivity
Study type: Interventional
Phase: Phase 2

Summary: 
      Evaluate the safety and efficacy of atomoxetine in Japanese pediatric patients with ADHD.
    


Intervention name(s): Atomoxetine Hydrochloride
Intervention type(s): Drug
Intervention MeSH terms: Atomoxetine Hydrochloride
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Comparison of the Functional Walking Outcomes of Two Settings of a Commercially Available AFO in Adult Stroke Patients
Condition: Walking Aided by a Leg Brace in Stroke Subjects
MeSH terms: Stroke
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate how two different settings of a commercially
      available ankle foot brace affect how stroke patients walk. The study brace is an ankle foot
      orthosis (AFO) that makes use of a newer type of joint that contains a soft insert, in
      addition to the conventional hard stops, to limit the range of motion of the ankle during
      walking. The results of this study will help to clarify 1) whether and how this new joint
      affects the way you walk, 2) whether it makes it easier for the clinician to align your brace
      and 3) your opinions about the new joint.
    

Detailed description: 
      The purpose of this study is to evaluate how two different settings of a commercially
      available ankle foot brace affect how stroke patients walk. The study brace is an ankle foot
      orthosis (AFO) that makes use of a newer type of joint that contains a soft insert, in
      addition to the conventional hard stops, to limit the range of motion of the ankle during
      walking. Participants undergo testing in the gaitlab after using the new brace for a period
      of time. The results of this study will help to clarify 1) whether and how this new joint
      affects the way you walk, 2) whether it makes it easier for the clinician to align your brace
      and 3) your opinions about the new joint.
    

Intervention name(s): ADR™ brace resistance; Conventional brace resistance (using hard stops)
Intervention type(s): Device; Device
Intervention description(s): Conventional polypropylene custom molded ankle foot orthosis (MAFO) with Lawrence style double channel adjustable joints containing pins/springs
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Influence of Obesity on Propofol Pharmacokinetics During Cardiopulmonary Bypass
Condition: Obesity
MeSH terms: Obesity
Study type: Observational

Summary: 
      The primary objective of this study is to develop a descriptive and predictive
      pharmacokinetics model propofol disposition during cardiopulmonary bypass (CPB) in obese and
      lean patients.
    

Detailed description: 
      Anaesthesia maintenance upon initiation of CPB will be achieved by propofol (1%) bolus (1
      mg/kg TBW) immediately followed by 2 mg/kg TBW/hr infusion that will be continued till
      weaning from CPB. During CPB an additional propofol bolus doses can be administered to
      prevent awareness according to the clinical judgment of the responsible anaesthesiologist.
      Any additional doses given and their timings will be recorded.

      Blood samples of 2 ml each will be collected from the arterial line of CPB machine until the
      end of CPB then from sub-clavin arterial catheter routinely inserted in such surgeries.
      Sampling process will follow the following schedule; at baseline prior to dosing, followed by
      samples at 1, 3, 5,7 min after the propofol bolus dose, then every 20 minutes during propofol
      infusion, just before discontinuation of the propofol infusion and at 1, 3, 5, 7, 10, 20, 30,
      60 minutes after the end of infusion. In addition, just before any rescue propofol dose
      administration, an unscheduled sample will be withdrawn
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients undergoing elective cardiac surgery using Cardiopulmonary bypass with moderate
        hypothermia (defined as core body temperature of 28-32oC).
      
Keywords: Propofol; Cardiopulmonary Bypass; Pharmacokinetics; Obesity
Effectiveness of an Exercise Protocol on Alteration of Knee Joint Position Sense in Futsal Players
Condition: Proprioceptive Disorders; Knee Injuries; Athletic Injuries
MeSH terms: Somatosensory Disorders; Wounds and Injuries; Knee Injuries; Athletic Injuries
Study type: Interventional

Summary: 
      This research presents a randomized clinical trial which evaluates the effectiveness of an
      exercise protocol on the knee-joint repositioning in futsal players related to a post-match
      muscle fatigue. Our hypothesis is the improvement of sensation in a knee in joint position
      before and after the match when performing our exercise program.
    


Intervention name(s): exercise protocol
Intervention type(s): Other
Intervention description(s): The multi-intervention exercise protocol consists in a performance of agility, strength and balance exercises. It has to be fulfilled during 6 weeks (twice a week) before the regular training performance. The exercises should be done for almost 15 minutes approx. There will be 6 exercises in total: squat with toe raise, one-leg squats, single-leg balance (throwing a ball with a partner), vertical jumps, hamstring exercise, quick forwards and backwards sprints.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Prevention
A Study to Determine Safety of Durvalumab After Sequential Chemo Radiation in Patients With Unresectable Stage III Non-Small Cell Lung Cancer
Condition: Non-small Cell Lung Cancer (NSCLC)
MeSH terms: Lung Neoplasms; Carcinoma, Non-Small-Cell Lung
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a Phase II, open-label, multi-centre study to determine the safety of a fixed dose of
      Durvalumab (MEDI4736) (1500 mg) every 4 weeks [q4w] in participants with unresectable Stage
      III Non-Small Cell Lung Cancer (NSCLC), who have not progressed following platinum-based
      sequential chemoradiation therapy (sCRT). This study will be conducted in Europe and North
      America.
    

Detailed description: 
      This is a Phase II, open-label, multi-centre study to determine safety of a fixed dose of
      Durvalumab (MEDI4736) (1500 mg) monotherapy in participants with unresectable Stage III NSCLC
      who have not progressed following definitive, platinum-based sCRT. Approximately, 150
      participants will be treated with the study drug in Europe and North America. Participants
      will be in complete response (CR), partial response (PR), or have stable disease (SD)
      following definitive, platinum-based sCRT, as assessed by the Investigator and further
      supported by the screening imaging radiological assessment. Participants must not have
      progressed following definitive, platinum-based sCRT; radiation therapy must be completed
      within 42 days prior to first Investigational product (IP) dose administration. Participants
      must have histologically- or cytologically-documented NSCLC and locally-advanced,
      unresectable Stage III disease. Participants will be treated with the study drug in 2
      cohorts: approximately 100-120 participants in the World Health Organization/Eastern
      Cooperative Oncology Group Performance Status (WHO/ECOG PS) 0 to 1 Cohort and up to 30
      participants in the WHO/ECOG PS 2 Cohort.
    

Intervention name(s): Durvalumab
Intervention type(s): Drug
Intervention description(s): Participants will receive 1500 mg Durvalumab monotherapy via IV infusion q4w for up to a maximum of 24 months with the last administration at Week 104.
Other intervention name(s): MEDI4736
Intervention MeSH terms: Durvalumab
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Stage III Non-Small Cell Lung Cancer; Durvalumab; IV infusion immunoglobulin G (IgG); Antibody-dependent cellular cytotoxicity; Complement-dependent cytotoxicity; Monotherapy
CI(R)CA : Coumadin Interaction With Rofecoxib, Celecoxib and Acetaminophen
Condition: Antiphospholipid Antibody Syndrome
MeSH terms: Antiphospholipid Syndrome
Study type: Interventional

Summary: 
      Coumadin drug-drug interactions (DDI) are frequent. Patients in permanent use of coumadin are
      advised to avoid traditional nonsteroidal antiinflammatory drugs to avoid risk of bleeding.
      New selctive cyclooxygesase 2 inhibitors arisen as potential option for treating pain and
      inflamation in these patients once interactions with coumadin are supposed to be lower. The
      CI(R)CA study was made to evaluate in a prospective fashion the occurrence of DDI with new
      cyclooxygenase antiinflammatory drugs and coumadin when compared to acetaminophen and
      placebo.
    

Detailed description: 
      The CI(R)CA study included patient diagnosed with antiphospholipid syndrome in permanent use
      of coumadin. Eligible patients were invited to use in a prospective cross-over mode two weeks
      of celecoxib, rofecoxib, acetaminophen and placebo with two weeks of wash out between drugs.
      Their international normalized ratio (INR) were measured before and during the use of each
      study drug. The interaction with coumadin was evaluated according to increases or decreases
      on the INR after each medication.
    

Intervention name(s): Celecoxib; Acetaminophen; Rofecoxib; placebo
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): celecoxib 200mg/day by oral rout during 15 days followed by the administration of rofecoxib 25mg/day, acetaminophen 3g/day and placebo during 15 days each drug.; Acetaminophen 3g/ was given during 15 days by oral rout following one of the other interventions or as the final intervention.; Rofecoxib 25mg/day was given by oral rout during 15 days following one or more interventions or as the final intervention.; Placebo pills were given during 15 days by oral rout as one of the four interventions.
Other intervention name(s): celebrex; Tylenol; Vioxx
Intervention MeSH terms: Acetaminophen; Celecoxib; Rofecoxib
Intervention model: Single Group Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Coumadin; celecoxib; rofecoxib; acetaminophen; antiphospholipid syndrome and INR
Sickle Cell Uric Acid (SCUA) - Cohort Repository
Condition: Chronic Kidney Diseases; Sickle Cell Disease
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic; Anemia, Sickle Cell
Study type: Observational [Patient Registry]

Summary: 
      The purpose of this research is to study the causes of Sickle Cell kidney disease, as well as
      to collect and store samples and information about people with Sickle Cell Disease.
    

Detailed description: 
      Sickle Cell Disease causes kidney injury over time, but it is not clear why some individuals
      have very significant chronic kidney disease and why some do not. The purpose of this
      research is to study whether having high levels of 'uric acid,' which is a naturally
      occurring molecule in the body that may increase kidney injury and systemic inflammation,
      accelerates the progression of chronic kidney disease over time. Researchers will measure the
      number of participants that have high uric acid levels at the beginning of the study, as well
      as the number of participants that develop new high levels throughout the study. The study
      will also try to determine what causes the high uric acid levels in some patients but not
      others. The results of this study could help understand kidney injury and uric acid in sickle
      cell disease better.
    

Intervention name(s): No intervention
Intervention type(s): Other
Intervention description(s): No intervention - observational study
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Participants currently receiving medical care from the pediatric or adult hematology
        comprehensive sickle cell centers.
      
Biospecimen description: 
      Urine and Serum samples will be stored in a research repository
    
Keywords: Uric acid
Effectiveness of Silver Diamine Fluoride as a Treatment for Caries in Comparison to Traditional Restorative Techniques
Condition: Caries
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to compare standard fillings and silver diamine fluoride (SDF)
      for treatment of cavities in baby teeth. The investigators will compare the effectiveness of
      stopping the cavity, cost of the treatments and the opinions of the families and the dental
      providers.
    

Detailed description: 
      To determine the effectiveness of the application of silver diamine fluoride (SDF) in
      comparison to conventional restorative treatments in International Caries Detection and
      Assessment System criteria (ICDAS) 5 and 6, one and two surface carious lesions in primary
      molars which will be assessed based on major and minor failure criteria when followed for one
      year. Additionally, parents'/children's and providers' perceptions will be assessed as well
      as the cost of both regimens, to include both chair time spent and materials' costs.
    

Intervention name(s): Silver Diamine Fluoride; Conventional Caries Management
Intervention type(s): Device; Procedure
Intervention description(s): No caries removal will take place. The tooth will be dried and Silver Diamine Fluoride will be placed on the carious dentin until saturated. Excess will be blotted dry with a cotton pellet.; These children will receive restorative dental care in alignment with the American Academy of Pediatric Dentistry guidelines, within the confines of the Mott Children's Health Center clinic. This treatment typically includes administration of local anesthesia, placement of rubber dam, caries removal with rotary and hand instruments, and placement of a final restoration.
Other intervention name(s): Silver Dental Arrest; Filling; Restoration
Intervention MeSH terms: Fluorides
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Caries; Cavity
The Effect of Left Uterine Displacement on Parturient Cardiovascular System
Condition: Cardiac Output
Study type: Interventional

Summary: 
      The aim of the study is to investigate the effect of different angles of lateral tilt on the
      maternal hemodynamics before and after spinal anesthesia
    

Detailed description: 
      At operating room, patients will be monitored using non invasive blood, ECG, pulse oximeter
      and electrical cardiometry. Baseline readings will be taken in supine position then repeated
      after putting the patient in left lateral position with angle 15 then 30 degrees.

      Then two IV lines will be inserted and 500cc crystalloid will be administered. Subarachnoid
      block will be performed in sitting position under complete aseptic conditions using 25 g
      spinal needle. Subarachnoid block will be achieved by injecting 10 mg hyperbaric bupivacaine
      plus 25 ug fentanyl. The block will be considered successful if adequate block reached T4
      dermatome.

      After successful block the hemodynamic variables will be recorded in the same positions as
      before (0,15, 30 degrees left uterine tilt).

      A minimum number of 61 patients was calculated to have a study power of 80% and alpha error
      of 0.05.

      SPSS Chicago 18 software will be used for data analysis. Categorical data will be presented
      as frequencies, continuous variables will presented as mean ± standard deviation and will be
      analyzed using on way analysis of variance (ANOVA) with post-hoc pairwise comparisons using
      bonferroni test. A P value of 0.05 will be considered statistically significant.
    

Intervention name(s): electric cardiometry; IV line insertion; spinal anesthesia ( subarachnoid block ); electric cardiometry
Intervention type(s): Procedure; Procedure; Procedure; Procedure
Intervention description(s): The following measured variables were recorded using electric cardiometry heart rate, stroke volume, cardiac output, systemic vascular resistance.
these parameters are measured on arrival to operating room before subarachnoid block in three different angles of lateral uterine tilt ( 0, 15 and 30 degrees ); two Iv lines are inserted and 500cc crystalloid is administered to parturient .; Subarachnoid block (SAB) was performed in sitting position under complete asepsis using 25 g spinal needle. SAB was achieved by intrathecal injection of 10 mg hyperbaric bupivacaine plus 25ug fentanyl. Success of SAB was tested within five minutes after drug injection. SAB was considered successful if adequate block reached T4 dermatome.; after SAB the following measured variables were recorded using electric cardiometry heart rate, stroke volume, cardiac output, systemic vascular resistance at three different angles of left uterine lilt (0,15,30 degrees)
Intervention MeSH terms: Anesthetics
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: cardiometry; uterine displacement
Generic Database of Moderate Preterm Infants
Condition: Infant, Newborn; Infant, Moderate Preterm
MeSH terms: Premature Birth
Study type: Observational [Patient Registry]

Summary: 
      This is a registry of moderate preterm infants, born alive at 29-33 weeks gestational age, in
      NICHD Neonatal Research Network (NRN) centers. The registry collects observational baseline
      data on both mothers and infants, and the therapies used and outcomes of the infants. The
      information collected is not specific to a disease or treatment (i.e., it is "generic"). Data
      are analyzed to find associations and trends between baseline information, treatments, and
      infant outcome, and to develop future NRN trials.
    

Detailed description: 
      The Moderate Preterm Registry is a registry of moderate preterm infants (29-33 weeks
      gestational age) born alive in NICHD Neonatal Research Network (NRN) centers. The purpose is
      to collect baseline and outcome data in a uniform manner on a cohort of infants.

      The registry collects observational baseline data on both mothers and infants, and the
      therapies used and outcomes of the infants. The information collected is not specific to a
      disease or treatment (i.e., it is "generic"). Baseline data is collected soon after admission
      to the NICU; outcome data is collected at the time of death or discharge from the hospital.
      The data collected includes information on:

        -  Demographics of mother and infant

        -  Mother's health (e.g., pregnancy history and complications)

        -  Labor and deliver (e.g., rupture of the membranes, steroids and antibiotics given, mode
           of delivery)

        -  Infant's health (gestational age, Apgar scores, weight, length, delivery room
           resuscitation, respiratory support, etc.)

        -  Infant's medical outcome (heart, lung, nervous system, gastrointestinal system, hearing,
           and vision, known infections, and major malformations/syndromes, and mortality or number
           of days hospitalized).

      These data are used: to examine associations between baseline characteristics, treatments,
      and outcomes; to track trends in incidences of disease and effectiveness of therapies; and to
      identify questions requiring additional in-depth research.

      Informed Consent: As required by local IRBs.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Moderately preterm infants born at 29 0/7 weeks to 33 6/7 weeks-both inborn and outborn but
        admitted prior to 72 hours at NRN centers will be included in this study.
      
Keywords: NICHD Neonatal Research Network; Moderately Preterm