Upper-body High-intensity Interval Training and Mixed Meal Responses
Condition: High-Intensity Interval Training
Study type: Interventional

Summary: 
      Cycling and running-based high-intensity interval training are well-established to improve a
      variety of health outcomes. However, the efficacy of upper-body high-intensity interval
      training, vital for individuals with lower-body impairments, has yet to be
      well-characterized. The purpose of this study is to compare the effect of a single bout of
      upper-body high-intensity interval exercise (HIIE) in comparison to traditional
      moderate-intensity continuous exercise (MICE) on the blood response (e.g. glucose, insulin,
      fats) following a meal.

      This study is recruiting able-bodied adults (aged 18-65 years). Participants will need to
      attend the laboratory at the University of Bath for two preliminary sessions, and three main
      study trials.
    

Detailed description: 
      The aim of this research is to determine the metabolic responses to a mixed-meal tolerance
      test following an acute bout of HIIE and an energy-matched MICE bout in able-bodied persons.
      The hypothesis is that HIIE and MICE will be more effective at reducing the total
      triglyceride responses compared to a resting control condition.

      Preliminary measurements:

      Preliminary testing will include measurements of weight and height. There will also be an
      assessment of resting metabolic rate and maximal exercise capacity. On a second visit, a HIIE
      familiarisation session will be performed to determine total energy expenditure of the
      session. All of the exercise protocols will take place on an arm crank ergometer at the
      University of Bath.

      Main trial days:

      Before all main trials, participants will be asked to refrain from performing any strenuous
      physical activity in the 48-h prior (i.e. day 0 and 1) and consuming alcohol/caffeine in the
      24-h prior (i.e. day 1). On day 1, participants will be asked to record/replicate their diet
      using a weighed food-diary. Participants will be asked perform exercise (HIIE and MICE only)
      at 18:00 on day 1, having consumed no food (other than plain water) from 14:00. They will be
      given a standardised dinner to eat at 20:00, and asked to avoid the ingestion of any further
      food (other than plain water) for the rest of the evening.

      On day 2 and upon arrival to the laboratory, a cannula will be inserted into a vein, and a
      baseline blood sample and expired air sample will be taken. The participant will then be
      asked to consume a smoothie, consisting of peanut butter, banana, coconut oil, sugar, and
      chocolate-flavoured whey protein powder. The meal should be consumed within 10 minutes and
      blood samples will be taken from the cannula at 15, 30, 45 60, and 90 minutes and then at
      every hour for 5 hours after consumption of the meal to monitor changes in metabolic markers.
      Expired gas samples will also be taken hourly and indirect calorimetry will be used to
      estimate relative fat and carbohydrate metabolism in response to the meal.
    

Intervention name(s): High-intensity interval training; Moderate-intensity continuos training
Intervention type(s): Other; Other
Intervention description(s): Arm-cranking exercise; Arm-cranking exercise
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: postprandial metabolism