bioihbjkbjnl/mcl2 huggingface dataset:
Characterization of Airway Mucus in Bronchiectasis Patients and Healthy Controls
Condition: Bronchiectasis Adult
MeSH terms: Bronchiectasis
Study type: Observational

Summary: 
      Analysis of mucus, mucin and DNA concentration, MUC5B/5AC ratio, rheology, osmotic pressure,
      cohesion and nucleotides in sputum on 30 individual samples of good quality in healthy
      individuals and those with bronchiectasis. (60 total)
    

Detailed description: 
      In this study the investigators will investigate the mucus properties in individuals with
      idiopathic bronchiectasis and healthy individuals without a history of lung disease. In order
      to understand how mucus is abnormal in disease conditions, the investigators need to
      understand the mucus biochemical and biophysical properties in healthy individuals. In this
      study the investigators will prospectively recruit patients with bronchiectasis and healthy
      individuals from the community to provide airway sputum samples. In these samples the
      investigators will measure an array of mucus properties. This will help our understanding of
      the mucus-obstructive lung diseases and facilitate the development of appropriate and
      effective disease prevention strategies.

      A key question is whether mucus is hyper-concentrated and has abnormal biophysical properties
      in individuals with mucus-obstructive lung disease. To answer this question, the
      investigators need to understand the properties of the mucus in individuals with idiopathic
      bronchiectasis and no history of lung disease. This study will allow us to collect airway
      mucus (sputum) from individuals with bronchiectasis and healthy individuals with no history
      of lung disease.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The proposed study will recruit 30 patients with bronchiectasis and 30 healthy individuals
        with no history of lung disease aged over the age of 18 years.
      
Biospecimen description: 
      sputum
    
Keywords: sputum; bronchiectasis; lung disease
A Clinical Study to Evaluate the Efficacy of a Range of Dental/Denture Products for Improved Oral Health in Partial Denture Wearers
Condition: Gingivitis
MeSH terms: Gingivitis
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to investigate the effectiveness of usage of a range of oral
      products (toothpaste, mouth rinse, denture cleanser) on the oral health of partial denture
      wearers compared to existing oral hygiene habits.The hypothesis is that there is no treatment
      difference in the oral health when using the range of products for 12 weeks compared to no
      intervention.
    

Detailed description: 
      This study is a single-center, single-blind (to the examiner(s) performing the plaque,
      gingivitis, denture cleanliness and oral hygiene assessments), randomized, stratified (by
      denture material type and baseline mean overall modified gingival index [MGI] score),
      two-treatment, parallel group, 12 week clinical study in generally healthy, adult
      participants with at least one conventional removable partial denture (RPD) and generalized,
      mild-moderate, plaque-induced gingivitis (as determined by clinical examiner) and greater
      than or equal to >=4 natural teeth in each arch that meet all study criteria at both the
      Screening and Baseline visits (including >= 30 evaluable surfaces for clinical evaluation of
      gingivitis and plaque). The study will examine the effects of twice daily use of a range of
      dental/denture products (comprising use of a dentifrice, a mouthrinse and a denture cleanser)
      compared to no intervention (participants who continue with their existing oral hygiene
      habits). There will be four visits to the study site: screening, baseline (when participants
      are randomized), and after 6- and 12 weeks use of the range of dental/denture products.
    

Intervention name(s): Experimental Dentifrice: Stannous Fluoride; COREGA Denture Foaming Cleanser; Mouth rinse: Sodium Fluoride
Intervention type(s): Other; Device; Other
Intervention description(s): Participants will be instructed to dose the toothbrush provided with a strip of dentifrice (a full brush head) on each brushing occasion containing 0.454% w/w Stannous fluoride for 2 minutes twice daily (morning and evening) for 12 weeks.; Participant will clean their denture using 2 pumps of the denture cleansing foam and a denture cleaning brush for 90 timed seconds outside of the mouth twice daily (morning and evening) for 12 weeks.; Participants will take 10 ml of the mouth rinse containing 90 ppm sodium fluoride and swished around the mouth for 1 minute twice daily (morning and evening) for 12 weeks.
Intervention MeSH terms: Listerine; Fluorides; Sodium Fluoride; Tin Fluorides
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
The Effect of Priming Intravenous Rocuronium on Fentanyl-Induced Coughing
Condition: Fentanyl-induced Coughing
MeSH terms: Cough
Study type: Interventional

Summary: 
      An intravenous bolus of fentanyl often induces a cough reflex. This study investigates
      whether priming with rocuronium can attenuate fentanyl-induced coughing effectively.
    

Detailed description: 
      Fentanyl is widely used for analgesia and anesthesia because of its rapid onset, its intense
      analgesic effect, and is associated with lessened cardiovascular depression and low histamine
      release. Although the cough reflex is usually transient and self-limiting, it should be
      avoided in situations such as elevated intracranial, intraocular, or intra-abdominal
      pressure, and unstable hemodynamics.

      The cause of FIC is unclear. One hypothesis is that vocal cord spasms might induce coughing
      because of fentanyl-induced muscle rigidity and histamine release. Muscle relaxants are
      commonly used to treat this condition. This study hypothesizes that priming muscle relaxants
      could prevent or suppress FIC. This study investigates whether the muscle relaxant rocuronium
      attenuates FIC effectively.
    

Intervention name(s): Rocuronium
Intervention type(s): Drug
Intervention description(s): All patients were given oxygen via a face mask. The patients were then administered with the following medications intravenously: the rocuronium group received rocuronium 0.06 mg kg-1, and the control group received the same volume of normal saline 30 s before the injection of an IV fentanyl bolus (1.5 mcg kg-1, within 2 s).
Intervention MeSH terms: Rocuronium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: fentanyl-induced coughing, rocuronium
Cortical Activity During Vojta Stimulation in Healthy Adults
Condition: Brain
Study type: Interventional

Summary: 
      The present study is focused on the importance of sensory stimuli at the tactile and
      proprioceptive level that occur during the activation of the pectoral area, following the
      treatment protocol of Vojta Therapy (VT), and which are the areas that are activated in the
      central nervous system (CNS) during stimulation, as well as muscle activity. For the
      activation record it will be used electroencephalography and electromyography electrods.
    

Detailed description: 
      The relationship between intrinsic and extrinsic factors condition the development of the
      human being. The sensory organs are the main recipients of the information, thanks to them we
      are able to interact with the environment and register the influence of the stimuli inside
      the organism. The brain receives information from the environment through its senses.

      At the tactile level the brain receives afferent information thanks to the activation of
      mechanoreceptors of the skin during interaction with the environment. The receivers encode
      the stimulus information and send it to the specific CNS structures. In these structures, the
      sensations received are combined and the stimulus is transformed into a perfectly elaborated
      response, both in a conscious and innate way.

      Dr. Vojta showed in 1974 the locomotion reflects the result of the study of motor
      ontogenesis. This discovery was the demonstration of the existence of innate and
      preprogrammed motor patterns in Humans.

      Most of the studies related to VT have showed the improvements obtained by the patients,
      validating it as a method of treatment and evidencing objective changes after its
      application. This research aim to go further and verify that cortical areas are activated
      during the application of an external and proprioceptive stimuli that are performed during
      the first phase of VT turning and which areas are responsible for producing and organizing
      the efferent response.
    

Intervention name(s): Vojta; Sham
Intervention type(s): Other; Other
Intervention description(s): Reflex locomotion stimulus; sham stimulus
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Basic Science
Keywords: Electroencephalography; Electromyography; Tactile stimulation; Vojta therapy
OxyGenesys Dissolved Oxygen Dressing; Abdominoplasty at Northwestern University
Condition: Wounds
Study type: Interventional

Summary: 
      Twelve acute wounds (6 on either side of the umbilicus) will be surgically created in the
      lower abdominal area. One side of the umbilicus will be randomized to Oxygenesys treatment
      arm and the other side will be receiving a standard Tegaderm treatment arm. Time to wound
      healing will be observed over 14 days.
    

Detailed description: 
      At least 12 study visits will occur over a 3 month timeframe. Twelve acute wounds (6 on
      either side of the umbilicus) will be surgically created in the lower abdominal area. One
      side of the umbilicus will be randomized to Oxygenesys treatment arm and the other side will
      be receiving a standard Tegaderm treatment arm. Time to wound healing will be observed over
      14 days (follow up assessments include wound photography, pain scores, wound biopsies,
      exudate collection, gene expression and proteomic analysis, scar assessment and adverse event
      collections. Study visits will occur at:

      Prescreening Visit; Day of wounding; Day 2; Day 7; Day 8-14 (until all wounds have healed);
      Day 28; Day 42; Abdominoplasty Surgery. An abdominoplasty will occur after day 42.
    

Intervention name(s): OxyGenesys Dissolved Oxygen Dressing
Intervention type(s): Device
Intervention description(s): 1/2 of the abdominal wounds will be covered with Oxygenesys Dissolved Dressing.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Feasibility Study of PID Versus MPC and HMS
Condition: Type 1 Diabetes Mellitus
MeSH terms: Diabetes Mellitus, Type 1
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The goal of this proposed study is to explore the feasibility of using a PID
      (Proportional-Integral-Derivative) controller versus an MPC (Model Predictive Control)
      controller algorithm in an artificial pancreas system, all other components and study design
      being equal.

      The study consists of an evaluation of either type of control algorithm as a part of the
      Artificial Pancreas (AP) device during two periods of 27.5-hour closed-loop control in a
      clinic environment (Sansum Diabetes Research Institute, Santa Barbara, CA) separated by a
      minimum of 5 days and a maximum of 2 weeks. The 27.5-hour period includes: 2 announced meals
      (dinner and breakfast of 65g and 50g CHO respectively) preceded with a dose of rapid-acting
      insulin equivalent to 100% bolus based on each subject's Insulin to Carbohydrate (I:C) ratio
      and 1 unannounced meal (lunch of 65g carbohydrates, same meal content as dinner); complete
      night from 12:00 am to 7:00 am. The goal is to demonstrate that the AP device is able to
      maintain the subject blood glucose within a safe range at all times.
    


Intervention name(s): MPC control algorithm; PID control algorithm
Intervention type(s): Device; Device
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: artificial pancreas
Eat Healthy for Families
Condition: Obesity, Childhood; Energy Density; Diet Quality
MeSH terms: Pediatric Obesity
Study type: Interventional

Summary: 
      This study investigates the effect of a low energy-density dietary prescription as compared
      to MyPlate recommendations in preschool children at risk for obesity.
    


Intervention name(s): family-based obesity prevention lifestyle intervention
Intervention type(s): Behavioral
Intervention description(s): A family-based obesity prevention lifestyle intervention is based on the combination of behavioral therapy strategies, a physical activity prescription and a dietary prescription. Both the parent and child will be working to achieve the same behavioral targets.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
In Vivo Specificity of KUC 7483 CL Co-administered With Bisoprolol, Propranolol, and Acipimox in Healthy Male Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      Study to compare the metabolic and electrolyte effects of a single oral dose of 320 mg
      ritobegron administered alone or with a pre- and comedication with bisoprolol, propranolol
      and acipimox. In addition, to compare the metabolic and electrolyte effects of a single dose
      of 320 mg ritobegron with those of a single inhalatory dose of 100 μg salmeterol
    


Intervention name(s): KUC 7483 CL; Bisoprolol; Propranolol; Acipimox; Salmeterol
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention MeSH terms: Propranolol; Bisoprolol; Acipimox; Salmeterol Xinafoate
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Study of Multiple Doses of Saxagliptin (BMS-477118)
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 2

Summary: 
      To evaluate the positive efficacy trend among doses of saxagliptin (BMS-477118) in subjects
      with Type 2 diabetes mellitus by assessing the change from baseline in HbA1c following 12
      weeks of double-blind treatment.
    


Intervention name(s): Saxagliptin; Saxagliptin; Saxagliptin; Saxagliptin; Saxagliptin; Saxagliptin; Placebo
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Tablets, Oral, 2.5 mg, once daily, 12 weeks; Tablets, Oral, 5 mg, once daily, 12 weeks; Tablets, Oral, 10 mg, once daily, 12 weeks; Tablets, Oral, 20 mg, once daily, 12 weeks; Tablets, Oral, 40 mg, once daily, 12 weeks; Tablets, Oral, 100 mg, once daily, 6 weeks; Tablets, Oral, 0 mg, once daily, 6 and 12 weeks
Other intervention name(s): BMS-477118; BMS-477118; BMS-477118; BMS-477118; BMS-477118; BMS-477118
Intervention MeSH terms: Saxagliptin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Phase 1b Study of MEDI4736 in Combination With Tremelimumab in Subjects With Advanced Non-small Cell Lung Cancer
Condition: NSCLC; Non-small Cell Lung Cancer; Lung Cancer
MeSH terms: Lung Neoplasms; Carcinoma, Non-Small-Cell Lung
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine if MEDI4736 will be adequately tolerated in
      combination with tremelimumab in subjects with advanced non-small cell lung cancer (NSCLC).
    

Detailed description: 
      This is a multicenter, open-label, dose-escalation, and dose expansion study of MEDI4736 in
      combination with tremelimumab to evaluate the safety, tolerability, pharmacokinetic (PK),
      immunogenicity, and antitumor activity of MEDI4736 in combination with tremelimumab in adult
      subjects with advanced NSCLC.
    

Intervention name(s): MEDI4736; Tremelimumab; tremelimumab
Intervention type(s): Drug; Drug; Drug
Intervention description(s): MEDI4736 is an anti-PD-L1 monoclonal antibody (MAb).; Tremelimumab is an anti-CTLA4 monoclonal antibody (mAb).; Tremelimumab is an anti-CTLA4 monoclonal antibody (mAb).
Intervention MeSH terms: Durvalumab; Tremelimumab; Antibodies, Monoclonal
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: anti-CTLA-4; anti-PD-L1; immunotherapy; IMTC
The Role of High Intensity Interval Training in the Treatment of Adolescent Obesity
Condition: Pediatric Obesity; Adolescent Obesity; Weight Loss
MeSH terms: Obesity; Pediatric Obesity; Weight Loss
Study type: Interventional

Summary: 
      The study will compare the effects of High Intensity Interval Training (HIIT) with Moderate
      Intensity Continuous Training (CMIT) as part of a lifestyle intervention program on BMI
      change in adolescents age 12-16 with obesity.
    

Detailed description: 
      Adolescents will be randomized to a 12-week lifestyle intervention including behavioral and
      dietary interventions, and one of two exercise training conditions, HIIT or CMIT).
      Adolescents in the HIIT treatment will participate in treadmill exercise in 1-minute
      intervals of challenging intensities with recovery periods in between, gradually increasing
      the number of intervals over the course of the study. Adolescents in the CMIT treatment will
      participate in a constant moderate intensity treadmill exercise, gradually increasing the
      duration of the exercise over the course of the study.

      Both parents and teens will have height and weight measurements taken, complete behavior
      questionnaires and wear an activity monitor for one week at baseline, 12 weeks and 16 weeks.

      Adolescents will have a physical exam by a study medical provider before starting the
      intervention. Adolescents will also have blood work, an oral glucose tolerance test, an
      electrocardiogram, body composition measurements and a maximal graded exercise test done at
      baseline, and again at one or more time points. Adolescents will also complete a detailed
      food log at those time points.

      Adolescents will exercise at the study gym 3 evenings a week for 12 weeks. On one of those
      evenings teens will also attend a 60-minute individual behavioral weight management session.
      Nine of these are with a behavior coach, and 3 with a dietitian. Parents will also attend one
      introductory session with the behavior coach, join the teen for the 3 sessions with the
      dietitian, and review adolescent individual goals and identify parent support goals at the
      end of each behavior session.
    

Intervention name(s): High-Intensity Interval Training; Moderate-Intensity Continuous Training
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Participants assigned to HIIT will participate in treadmill exercise in intervals consisting of 1 minute intervals of challenging intensities with recovery periods in between, gradually increasing the number of intervals over the course of the study.; Participants assigned to CMIT will participate in constant moderate intensity treadmill exercise, gradually increasing the duration of the exercise over the course of the study.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 2x3 repeated-measures randomized control trial.
Masking: None (Open Label)
Primary purpose: Treatment
The Effects of Protein Supplementation in Females and Males Following Acute Eccentric Exercise
Condition: Muscle Damage
Study type: Interventional

Summary: 
      Examine the impact of the protein supplements leucine, HMB and BCAA on muscle recovery and
      inflammatory response following acute exercise.
    

Detailed description: 
      Participants, both females and males, will perform an acute bout of exercise. A bout of
      exercise that will involve multiple drop jumps. Prior to and post exercise, functional
      outputs will be measured and blood will be collected to quantify the inflammatory response.
      The protocol will involve attending the laboratory on 6 occasions over a two week period to
      complete the above measures.
    

Intervention name(s): Drop Jumps
Intervention type(s): Other
Intervention description(s): Perform 100 drop jumps from 40 cm height. The protocol is divided into 5 sets of 20 repetitions. Between each repetition participants get 10 seconds, and between each set 2 minutes rest. Stand on the box, drop of the box and land with feet shoulder width apart. Then immediately bend knee to approx 45 degrees and jump straight up. Throughout each jump hands are placed on hips and should not move.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomised control study with four groups, one control and three protein supplements.
Masking: Single (Participant)
Primary purpose: Treatment
PGL4001 Versus GnRH-agonist in Uterine Myomas
Condition: Uterine Myomas
MeSH terms: Myoma; Leiomyoma; Myofibroma
Study type: Interventional
Phase: Phase 3

Summary: 
      This trial will assess the efficacy and safety of PGL4001 versus GnRH agonist, over a 3-month
      period for the pre-operative treatment of pre-menopausal women suffering from excessive
      uterine bleeding due to uterine myoma.
    


Intervention name(s): PGL4001; leuprorelin
Intervention type(s): Drug; Drug
Intervention description(s): tablets; solution for injection
Other intervention name(s): Ulipristal acetate; GnRH-agonist
Intervention MeSH terms: Leuprolide; Ulipristal acetate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Uterine Myomas
A Study Comparing Swallowed Flovent and Placebo in Patients With Eosinophilic Disorders
Condition: Eosinophilic Esophagitis
MeSH terms: Esophagitis; Eosinophilic Esophagitis
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is assessing the efficacy of swallowed Flovent® vs. placebo for the
      treatment of eosinophilic esophagitis (EE).
    


Intervention name(s): Fluticasone Propionate
Intervention type(s): Drug
Intervention description(s): Flovent vs. placebo daily for 3 months
Intervention MeSH terms: Fluticasone; Xhance
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Eosinophilic Esophagitis