bioihbjkbjnl/mcl2 huggingface dataset:
Effect of the Coughing Technique During Subcutaneous Heparin Injection
Condition: Thyroidectomy; Colon Surgery; Cholecystectomy; Inguinal Hernia
MeSH terms: Cough; Hernia, Inguinal
Study type: Interventional

Summary: 
      Objective: to examine the effect of the medium intensity coughing technique during
      subcutaneous low molecular weight heparin injection on pain severity and individual
      satisfaction in general surgery patients. Method: a prospective, quasi-experimental study
      included 100 patients who had prescribed a subcutaneous low molecular weight heparin
      injection once in 24 hours. Each patient received two injections by the same researcher using
      standard injection technique with medium intensity coughing technique and only standard
      injection technique.
    

Detailed description: 
      Aims and objectives: The aim of this study was to examine the effect on the level of pain
      severity and satisfaction of patients of the medium intensity coughing technique applied to
      patients during the administration of subcutaneous low molecular weight heparin (LMWH)
      injection.

      Design: This research was a prospective quasi-experimental study. Methods: It was conducted
      with 100 patients in the General Surgery Clinic of a university hospital in the Marmara
      Region of Turkey. Subcutaneous LMWH injections were administered by the same nurse to the
      outer side of the right and left upper arms by the standard injection technique and the
      medium intensity coughing technique. Immediately after the subcutaneous LMWH injection was
      given, a researcher who did not know which injection method had been used asked the patients
      to evaluate their pain levels by the Visual Analog Scale (VAS) and their satisfaction with
      the performance of the injection by the Visual Individual Satisfaction Scale (VISS).
    

Intervention name(s): the medium intensity coughing technique
Intervention type(s): Other
Intervention description(s): The medium intensity coughing technique: Immediately before the subcutaneous LMWH injection was given, patients were asked to cough twice at a medium level. After that, they were asked to cough ten seconds later for a second time at the same level, and while they were coughing for the second time, the needle was inserted into the tissue.
Allocation: Non-Randomized
Intervention model: Sequential Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: subcutaneous heparin injection; coughing technique; pain; individual satisfaction; non-pharmacological method
A Pharmacokinetic Interaction Study Between Apatinib Mesylate and Repaglinide or Bupropion in Advanced Solid Tumor Subjects
Condition: Advanced Solid Tumor
MeSH terms: Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of the study was to assess investigate the pharmacokinetic effects of
      Apatinib Mesylate on CYP2C8 Substrate Repaglinide or CYP2B6 Substrate Bupropion and
      metabolite Hydroxy bupropion in Advanced solid tumor subjects.

      The secondary objective of the study was to assess the safety of Apatinib or/and Repaglinide
      and Bupropion.
    


Intervention name(s): Apatinib Mesylate; Repaglinide; Bupropion
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Apatinib will be administered daily from on D5 through D16; Repaglinide will be administered daily on D1 and D12; Bupropion will be administered daily on D2 and D13
Intervention MeSH terms: Repaglinide; Apatinib; Bupropion
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
the Association Between Thyroid Hormones and Metabolic Components in Patients With Obesity
Condition: Obesity; Euthyroid Condition; Metabolic Syndrome
MeSH terms: Obesity; Metabolic Syndrome
Study type: Observational

Summary: 
      This study collected clinical data of obese patients with euthyroid function, including age,
      gender, height, weight, BMI, waist circumference, blood pressure, fasting blood sugar, blood
      sugar 2 hours after sugar load, fasting plasma high-density lipoprotein cholesterol, fasting
      three acyl glycerin, free iodine thyroid hormone (FT3) and free thyroid hormones (FT4),
      thyroid stimulating hormone (TSH), follow-up information and etc. Via analyzing the data, the
      investigators want to investigate the association between thyroid hormones (THs) and
      metabolic components in obese patients with euthyroid function and to present the cutoff
      values of THs in order to provide new information for the risk stratification of metabolic
      syndrome in obese patients with euthyroid function.
    


Intervention name(s): no intervention
Intervention type(s): Other
Intervention description(s): This study collected data only without any intervention.
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        We enrolled obese patients with euthyroid function.
The Application of Personalized Titanium Plate in the Bone Tumors Around the Knee
Condition: Bone Tumors
MeSH terms: Bone Neoplasms
Study type: Interventional

Summary: 
      Microwave ablation of bone tumors is time-consuming and usually results in postoperative
      fractures. Hence the investigators designed and fabricated a titanium plate customized to the
      patient's bone structures for fixation after the removal of tumorous tissue, to improve the
      clinical outcomes of microwave ablation.
    

Detailed description: 
      3D models of tumor-bearing bone segments were constructed by using computed tomography (CT)
      and magnetic resonance imaging (MRI). The 3D models were used to design the model of
      personalized titanium plates. The model of the plates was transferred into a numerical
      control machine for manufacturing the personalized titanium plates by 3D printing technology.
      The plates were then surgically implanted for reconstruction assistance following
      microwave-induced hyperthermia to remove the bone tumor. Implementation parameters and knee
      function were then evaluated.
    

Intervention name(s): Personalized titanium plate
Intervention type(s): Procedure
Intervention description(s): 3D models of tumor-bearing bone segments were constructed by using computed tomography (CT) and magnetic resonance imaging (MRI). The 3D models were used to design the model of personalized titanium plates. The model of the plates was transferred into a numerical control machine for manufacturing the personalized titanium plates by 3D printing technology. The plates were then surgically implanted for reconstruction assistance following microwave-induced hyperthermia to remove the bone tumor. Implementation parameters and knee function were then evaluated.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Knee; Titanium Plate
Green Coffee Effect on Metabolic Syndrome
Condition: Supportive Care; Metabolic Syndrome; Obesity; Hypertension
MeSH terms: Metabolic Syndrome; Syndrome
Study type: Interventional

Summary: 
      The present study aimed to investigate the effect of green coffee bean extract (GCBE) on the
      inflammatory biomarkers in obese patients with a metabolic syndrome via analyzing some
      inflammatory biomarkers as resistin, TNF-α, total sialic acid, homocysteine, high sensitivity
      C-reactive protein (hs-CRP) and anti-inflammatory cytokine, adiponectin
    

Detailed description: 
      160 obese patients supplemented with either GCBE capsules (800 mg) daily or placebo for 6
      months and advised to take a balanced diet. Blood samples were collected at baseline and
      after three months of supplementation
    

Intervention name(s): Green coffee been extract; Placebo
Intervention type(s): Dietary Supplement; Other
Intervention description(s): supportive treatment; Placebo capsule
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 160 obese patients supplemented with GCBE capsules (800 mg) daily for six months
Masking: Double (Participant, Investigator)
Primary purpose: Supportive Care
Examining the Effects of Float-REST for Recovery in Individuals With Chronic Lower Back Pain
Condition: Pain, Chronic
MeSH terms: Back Pain; Chronic Pain; Low Back Pain
Study type: Interventional

Summary: 
      Researchers at the West Virginia University Rockefeller Neuroscience Institute are looking
      for volunteers to participate in a research study to evaluate what effects Float-REST
      (Restricted environmental Stimulation Technique) has on the stress response caused by chronic
      lower back pain.
    

Detailed description: 
      Chronic lower back pain has a profound impact on a patient's life and body. These patients
      face a litany of internal and external stressors. These stressors cause a detrimental
      sustained activation of the endogenous stress response, which is mediated by the autonomic
      nervous system. Our central hypothesis is that this high stress load exacerbates the symptoms
      of chronic pain by causing changes in how the brain processes pain signals from the
      periphery. If researchers can better understand how stress plays a role in the mitigation of
      pain, then there may be improvements in patient's quality of life. Restricted Environmental
      Stimulation Therapy (REST) flotation has been identified as a possible alternative treatment
      to pharmacological intervention for several conditions like generalized anxiety disorder by
      helping to reduce stress. However, there have yet to be any investigation into what affects
      that REST flotation has in chronic lower back pain.
    

Intervention name(s): Float-REST; Nappod
Intervention type(s): Other; Other
Intervention description(s): Participants will utilize sensory deprivation tanks.; Participants will utilize nappod.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Sensory Deprivation Tank; fMRI
AZD2423 Single Ascending Dose Study in Healthy Japanese Subjects
Condition: Healthy Volunteer
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a Phase I, single centre, randomised, double-blind, placebo-controlled, parallel
      group study to assess the safety, tolerability and pharmacokinetics of AZD2423 following
      single ascending dose administration to healthy Japanese subjects.
    


Intervention name(s): AZD2423; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): oral solution, single dose; oral solution,single dose
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Phase I; Japanese healthy volunteer; AZD2423
Study of Gene Expression Profiling and Immunological Mechanism Affects the Response of Immunotherapy
Condition: Malignant Tumor
MeSH terms: Neoplasms
Study type: Observational

Summary: 
      To investigate gene expression profile and immunological associated analysis relating to
      immunotherapy response of patients with malignant tumor presenting malignant cavity effusion
      after DC-CIK immunotherapy.
    

Detailed description: 
      1. The patients with malignant cavity effusion are treated with dendritic cells (DC) plus
           cytokine induced killer cells (CIK) locally.

        2. Malignant cavity effusion from cancer patients is obtained through puncture and is
           centrifugalized to get supernatant fluid and enrich cancer cells before and after the
           therapy.

        3. The enriched cancer cells which are flash frozen, as well as the supernatant, are stored
           at -80°C until processing.

        4. The T-Cell Receptor/B-Cell Receptor gene expression in cavity effusion is detected by
           micro-array to explore the mechanism that DC-CIK immunotherapy controls the malignant
           cavity effusion.

        5. Statistical analysis is performed using unsupervised hierarchical cluster.
    

Intervention name(s): Dc-CIK immunotherapy
Intervention type(s): Biological
Intervention description(s): The patients with malignant cavity effusion are treated with dendritic cells (DC) plus cytokine induced killer cells (CIK) locally.
Intervention MeSH terms: Immunomodulating Agents
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The malignant tumor patients present with malignant cavity effusion and can receive DC-CIK
        immunotherapy.
Desmopressin in Cardiac Surgery
Condition: Hemorrhage; Blood Loss, Surgical; Postoperative Hemorrhage
MeSH terms: Hemorrhage; Blood Loss, Surgical; Postoperative Hemorrhage
Study type: Interventional
Phase: Phase 4

Summary: 
      Patients undergoing cardiac surgery could develop excessive perioperative bleeding requiring
      transfusions of blood products.

      Desmopressin (DDAVP), already used for patients with von Willebrand syndrome, could reduce
      bleeding and transfusion requirements in these patients when administered ev (0.3 mg/kg) in
      20-30 minutes postoperatively.
    


Intervention name(s): Desmopressin (DDAVP); Placebo
Intervention type(s): Drug; Drug
Intervention MeSH terms: Deamino Arginine Vasopressin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Blood Loss; Postoperative Blood loss
Activity Treatment on Vestibular Rehabilitation
Condition: Vestibular Disorder
MeSH terms: Vestibular Diseases
Study type: Interventional

Summary: 
      In this study it was aimed to investigate the effects of home treatment program based
      standard activity on dizziness, balance and daily life activity in patients with dizziness
      complaint originated from chronic unilateral peripheral vestibular disorder and compare to
      effects of exercise-based home rehabilitation program.
    

Detailed description: 
      The aim of this study was to assess the effects of an activity training programme on
      dizziness, imbalance, and level of independence in daily living activities in patients with
      chronic dizziness. 75 patients between 18-65 years of age who diagnosed chronic peripheral
      vestibular disorders and individuals with vestibular rehabilitation indications were included
      in our study. Patients were randomly divided into 3 groups consist of 25 patients as an
      activity group, exercise group, and control group. Education was given to each group. İn
      addition, the activity group was performed a training activities program, the exercise group
      was performed in the Cawthorne-Cooksey exercises program. Therapy programs were prescribed
      once daily at home for 4 weeks. After demographic information was obtained from all patients,
      assessments were performed at the beginning and at the end of the treatment program (4
      weeks). Dizziness severity was assessed by the Visual Analog Scale (VAS), activities of daily
      livings were assessed by Vestibular Disorders Activity Questionnaire (VADL) and balance was
      assessed by Sensory Organization Testing (SOT).
    

Intervention name(s): occupational therapy based activity training programs; Physiotherapy based exercise training programs
Intervention type(s): Procedure; Procedure
Intervention description(s): Occupational therapy based activity training programs in which exercises based on physiotherapy are put into the purposeful activities at vestibular rehabilitation.; Cawthorne-cooksey exercises were performed at vestibular rehabilitation
Other intervention name(s): purposeful activities; Cawthorne-cooksey exercises
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Single (Participant)
Primary purpose: Treatment
The Effect of Proton Pump Inhibition on Palpitations
Condition: Arrhythmia
MeSH terms: Arrhythmias, Cardiac
Study type: Interventional
Phase: Phase 4

Summary: 
      Feeling of palpitations with no clear arrhythmia is frequently encountered in clinical
      practice. The majority of these patients have documented sinus rhythm even while having
      symptoms. Gastrointestinal association with such symptoms was first described by Ludwig von
      Roemheld (1871-1938).The investigators thought to investigate the effect of proton pump
      inhibition in patients with feeling of palpitations but no clear cause.
    

Detailed description: 
      One hundred and fifty patients with palpitations and no clear cause for their symptoms will
      be randomized to receive either proton pump inhibitor (PPI) (lanzoprazole 30 mg) or placebo
      for one month. At base line they will be investigated to rule out arrhythmia by documenting
      normal heart rate (less than 110 beat per minute) or ECG showing normal sinus rhythm or mild
      sinus tachycardia (Less than 110 per minute) during symptoms. Obvious causes such as anxiety
      due to a stressful event or organic causes such anemia or thyroid disorders should be also
      ruled out.

      Patient who agree to participate in the study will be asked to sign an informed consent. A
      baseline questionnaire with symptoms will be filled. They will then be randomized for
      treatment with either PPI or placebo once at night time. After 10 days of treatment they will
      be contacted and questioned regarding their symptoms. The two groups will be compared to see
      if there is any improvement of symptoms with treatment.
    

Intervention name(s): Lansoprazole Pill; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): once daily at night time; Placebo
Other intervention name(s): Lanzotec
Intervention MeSH terms: Lansoprazole; Dexlansoprazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: Palpitations
Prospective Randomized Controled Study on the Outcome of Greenhouse Tec in the Arthroscopic Treatment of Small to Medium Rotator Cuff Tear
Condition: Bone Marrow Stimulating; Modified Suture Bridge
MeSH terms: Rotator Cuff Injuries
Study type: Observational

Summary: 
      This study is aprospective cohort study on the outcome of a combination of bone marrow
      stimulation and modified suture bridge in the arthroscopic treatment of small and medium
      rotator cuff tear. The patients with small to medium rotator cuff injuries (less than 3cm in
      diameter) requiring arthroscopic surgery were collected. The patients were followed up before
      and 6 weeks, 3 months, 6 months and 12 months after surgery, including pain, functional
      score, joint range of motion, MRI and CT findings, complications and other quantitative and
      qualitative indicators. The self-control and intra group analysis were performed to evaluate
      the treatment effect; and the correlation analysis was performed on the treatment results To
      determine the important factors affecting the therapeutic effect.
    


Intervention name(s): The combination of bone marrow stimulation and modified suture bridge(Greenhouse tec)
Intervention type(s): Procedure
Intervention description(s): According to the anteroposterior diameter of the injury, single or double high braided thread were used to suture the tendon in a modified Mason Allen way without knotting. Bone marrow stimulation was carried out in the footprint area of rotator cuff. A 2.0 mm diameter cone was created with a depth of 1 cm and a spacing of 5 mm. Six to eight holes were made due to the diameter of the tear of rotator cuff until blood and fat droplets exudate. Then the threads were passed through the locking eyelet of the lateral row anchor. After tightening the threads, the anchor was screwed in at the distal part of the gteater tuberosity. With this new technique, the rotator cuff was repaired by one lateral row anchor without medial row knotting.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        According to the inclusion and exclusion criteria, 40 patients with small to middle rotator
        cuff injury treated by this technique（Greenhouse tec） in our hospital from September 2020
        to December 2021 were included.
      
Keywords: Rotator Cuff Repair
A Study To Evaluate An Interaction Between Maraviroc And Raltegravir In Healthy Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 4

Summary: 
      An open label study to evaluate an interaction between maraviroc and raltegravir in healthy
      subjects.
    

Detailed description: 
      Drug interaction study
    

Intervention name(s): Maraviroc; Maraviroc; Raltegravir; Raltegravir
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): 300 milligrams(mg) every 12 hours Days 6-11; Days 12-14: Raltegravir 400 milligrams(mg) every 12 hours, maraviroc 300 milligrams(mg) every 12 hours (AM doses only on Day 14); Days 12-14: Raltegravir 400 milligrams(mg) every 12 hours, maraviroc 300 milligrams(mg) every 12 hours (AM doses only on Day 14); 400 milligrams(mg) every 12 hours Days 1-3 Followed by washout Days 4-5
Other intervention name(s): Selzentry, Celsentri
Intervention MeSH terms: Raltegravir Potassium; Maraviroc
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Keywords: maraviroc; raltegravir; drug interaction study; healthy volunteers