Different Kinds of Acupuncture Treatment for Knee Osteoarthritis
Condition: Knee Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional

Summary: 
      Knee osteoarthritis (KOA) a chronic disease with symptoms of persistent pain or rest pain ,
      joint stiffness, numbness, limitation of activity and even disability, with significant
      associated costs and effects on individuals' life quality. Acupuncture as an approach for the
      management of chronic pain, is receiving increasing recognition from both the public and
      professionals. The aim of this study is to indicate the effects of three commonly used
      acupuncture treatments for KOA.
    

Detailed description: 
      360 subjects with KOA recruited from six centers will be randomized to six groups ,and
      receive four-week acupuncture, Electro-acupuncture, Moxibustion ,Warm-needling ,sham-needle,
      celebrex treatment. The primary outcomes are Visual Analogue Scale (VAS) and WOMAC function
      score.The Secondary outcomes are WOMAC pain score, WOMAC stiffness score,the Physical
      Activity Scale of the Elderly (PASE),knee joint swelling measurement and WHO-BREF life
      quality scale.The follow-up period is six months. This study will be a rigorous,randomized,
      sham and drug controlled trial focusing on using different kinds of acupuncture treatment for
      treating KOA.
    

Intervention name(s): treatment1; treatment2; treatment3; treatment4; treatment5; Celebrex
Intervention type(s): Other; Other; Other; Other; Other; Drug
Intervention description(s): Acupoints：Liangqiu（ST34）,Xuehai（SP10）,Neixiyan（EX-LE4）,Dubi(ST35),Yanglingquan (GB34)and Yinlingquan (SP9)
operation: the needles will be manipulated using techniques including lifting, thrusting, twisting, and rotating, until De Qi is achieved for 30 minutes.; Acupoints：Needling points are the same to the above group
operation: The electrode will be connected Neixiyan (EX-LE4) and Dubi (ST35) and electrode wire will be connected to the electro-acupuncture apparatus using dilatational wave with a frequency of 2/100 Hz, the current intensity is within participants'tolerance, for 30 minutes.; Acupoints：treating points are the same to the above group
Operation: During treatment, participants will choose to sit with knee buckling natural 90 degrees ,with the affected knee(s) exposed. Mild moxibustion are applied at the distance of 2-3 cm away from the skin of both the Neixiyan (EX-LE4) and Dubi (ST35) for 30 minutes.; Acupoints：Needling points are the same to the above group
Operation: Warm-needling acupuncture are applied at both Neixiyan (EX-LE4) and Dubi (ST35). That is to insert one zhuang(about 2cm)of Huai Qing Ai on the top of the needle, and burn the moxa at the lower end ,each acupoint applied 2 Zhuang for 30 minutes.; points：Sham Liangqiu（ST34）,Sham Xuehai(SP10), Sham Neixiyan(EX-LE4), Sham Yanglingquan(GB34),Sham Yinlingquan (SP9)
Operation: Sham acupuncture with non-meridian and non-acupoint needling method, respectively acupuncture 1cm away lateral to the above sham acupoints with a 0.18 * 25mm single-use needle with the depth of 1-2mm.; Drug: Celebrex (Celebrex, Capsules, Pfizer Pharmaceuticals Ltd), which will be applied 1 time daily( taken 0.2g one time orally ) Time of treatment :4 weeks Other Name: celecoxib
Intervention MeSH terms: Celecoxib
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: KOA; Acupuncture treatment; Multi-center RCT