bioihbjkbjnl/mcl2 huggingface dataset:
Shoulder Pain and Scapular Endurance
Condition: Musculoskeletal Pain Disorder; Sport Injury
MeSH terms: Shoulder Pain; Musculoskeletal Pain; Rheumatic Diseases; Collagen Diseases; Athletic Injuries; Somatoform Disorders
Study type: Interventional

Summary: 
      Objective: This study aimed to investigate the effects of regular exercising on scapular
      muscle endurance and shoulder pain in young individuals.

      Methods: Participants' clinical and sociodemographic properties recorded, scapular muscle
      endurance assessed with Scapular Muscular Endurance (SME) test, and shoulder pain severity
      questioned using the Visual Analogue Scale.
    

Detailed description: 
      Background: Serratus Anterior and Trapezius muscles are the most important stabilizers of the
      scapulothoracic joint. The inadequate endurance of these muscles plays an important role in
      the decreased neuromuscular performance.

      Objective: This study aimed to investigate the effects of regular exercising on scapular
      muscle endurance and shoulder pain in young individuals.

      Methods: Participants' clinical and sociodemographic properties recorded, scapular muscle
      endurance assessed with Scapular Muscular Endurance (SME) test, and shoulder pain severity
      questioned using the Visual Analogue Scale.
    

Intervention name(s): EXERCİSE
Intervention type(s): Other
Intervention description(s): EXERCISE FOR HEALTH AND PAIN IMPROVEMENT
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: In total, 200 individuals aged between 17-25 years, who had no neurological and orthopedic problems participated. Individuals who had surgical stabilization, previous shoulder complex fractures, positive impingement test results, and systemic diseases were excluded. Participants were categorized into the Regular Exercising (n = 100) and Sedentary (n = 100) Groups. The young adults who were using the fitness center by their preference (unprofessional), and who were regularly exercising, were included in the Regular Exercising Group. The volunteer young adults who were not exercising were included in the Sedentary Group. All participants gave written-informed consent before participation, and the study protocol conformed to the standards for human experiments set by the Declaration of Helsinki and was approved by Ethics Committee for Human Investigations of Mustafa Kemal University Ethics Committee (4298783/05022/4).
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Scapular Muscle Endurance; Shoulder Pain; Regular Exercising; Exercising
SPI Value Relevance in Clinical Practice
Condition: Anesthesia
Study type: Observational

Summary: 
      Primary endpoint: Defining The optimal target range for Surgical Pleth index. Surgical Pleth
      Index (SPI, formerly used SSI = Surgical Stress Index) is a novel multivariate index, which
      is based on the sum of the normalized pulse beat interval (PBI) and the photoplethysmography.
      SPI indicates the balance between intensity of surgical stimulation and the level of
      anti-nociception (opioid analgesia and neural blockade). This study is a Spin off from a
      larger Adequacy of Anaesthesia study and aims on finding the most appropriate target range
      for SPI in order to avoid signs of inadequate anaesthesia. Patients are treated without
      monitoring adequacy of anaesthesia thus the values are collected blinded and analyzed
      afterwards in accordance of signs for inadequate anaesthesia. The study population will be
      150 patients.
    

Detailed description: 
      Signs of non-adequate anaesthesia are motor and/or autonomic nervous system arousals during
      surgery.
    

Intervention name(s): Control group
Intervention type(s): Other
Intervention description(s): A group of no Monitoring patients from larger AoA study with no adequacy of anaesthesia monitoring
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients assessed for operation lasting more than two hours and requiring intubation.
Stool Transplant in Pediatric Patients With Recurring C. Difficile Infection
Condition: Clostridium Difficile Colitis
MeSH terms: Colitis
Study type: Interventional
Phase: Phase 2

Summary: 
      The incidence of C. difficile infection (CDI) has alarmingly increased over the past several
      years and the affected population has expanded to include those previously at low risk, such
      as children. The annual US financial burden associated with this infection is great and
      estimated to exceed $1.8 billion. C. difficile infection arises when the gut microbial
      ecology is disrupted during interventions notorious for perturbing the delicate microbial
      balance. A well known and common example is the use of antibiotics. Fecal microbiota
      transplant (FMT) has been introduced several decades ago in an attempt to restore the gut
      microbial balance. To this date there have been a great number of reports of success in
      eliminating recurrent C. difficile infections and restoring the gut microbial profile to
      resemble that of the healthy donor. While over 300 cases have been described in the
      literature, there has been no pediatric controlled studies performed to compare its efficacy
      to placebo. Therefore, there is a strong need to determine their safety and efficacy in
      pediatric randomized controlled studies. The investigators hypothesize that children with
      recurrent C. difficile infection will respond to fecal transplant therapy which will modify
      their gut microbial profile. The investigators propose a randomized, placebo controlled,
      pilot study of fecal microbial transplant in children with recurrent C. difficile infection
      to evaluate the safety and efficacy of fecal microbial transplant in children in preventing
      recurrent C. difficile infection. The investigators anticipate that fecal microbial
      transplant in children with recurrent C. difficile infection will be safe and efficacious and
      will provide these children with a great alternative to a disease that is difficult to treat.
      Results of this study will establish the major role of the gut microbiome in this disease and
      demonstrate the viability of gut microbial transplant in recipients.
    

Detailed description: 
      Forty six children with recurrent C. difficle infection will be randomized 1:1 to receive
      either fecal microbial transplant or placebo. The safety and efficacy of this intervention
      will be monitored for one year.
    

Intervention name(s): FMT; placebo
Intervention type(s): Biological; Biological
Intervention description(s): as explained in study arm; salt water or saline will be given as placebo
Other intervention name(s): fecal microbial transplant; stool transplant; saline; salt water
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: clostridium difficile; children; fecal transplant
Text Messaging Reminders for Influenza Vaccine in Primary Care
Condition: Influenza
MeSH terms: Influenza, Human
Study type: Interventional

Summary: 
      Influenza morbidity and mortality cause a substantial financial burden to the NHS and to the
      UK as a whole. Influenza vaccine is safe and effective but is required annually because the
      circulating strain of virus changes each year. In the UK in 2012, the Chief Medical Officer
      (CMO) recommended that at least 75% of elderly people (aged 65+) and 75% people under 65 with
      certain chronic conditions (e.g. chronic heart disease, diabetes, asthma, etc) should be
      vaccinated. While primary care practices are achieving these targets for elderly patients,
      those set for younger patients with chronic conditions are not being met, with a third of
      patients being missed in the 2011/12 flu season and with no substantial improvements in
      uptake in the past decade. Therefore strategies to increase flu vaccine uptake in these
      patients are required.

      Previous trials have shown that patient reminders can increase vaccine uptake and in
      particular, text messaging has shown to work in some populations in the United States as a
      cheap, simple and effective reminder. However, whether the same is true in UK general
      practice is unclear. The use of text messaging in the NHS for appointment reminders is also
      increasing as it is cheap, quick and effective. Text messaging is already used in roughly 30%
      of practices to remind patients about their flu vaccine but there has been no trial
      addressing its effectiveness. Therefore, we propose a trial of a text messaging flu vaccine
      reminder in patients aged under 65 who have a chronic condition. We hypothesise that
      practices that send a text message will have increased flu vaccine uptake.
    


Intervention name(s): Text message influenza vaccination reminder; Standard care
Intervention type(s): Other; Other
Intervention description(s): Practices in the text messaging intervention arm will be asked to send a text message to patients under 65 at risk of influenza.; Practices in the standard care arm will be asked to proceed with their seasonal influenza campaign as planned.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Keywords: Text messaging
Study the Safety and Effectiveness of MK7009 in Hepatitis C Infected Patients (MK-7009-004)(COMPLETED)
Condition: Hepatitis C
MeSH terms: Hepatitis A; Hepatitis C; Hepatitis
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to investigate the effectiveness, safety, and tolerability of
      MK7009 in patients infected with Hepatitis C
    


Intervention name(s): Comparator: MK7009; Comparator: Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Depending on group assignment, patients will receive once daily (q.d.) dosing for 8 days or twice daily (b.i.d.) dosing for 7 days plus one additional dose on Day 8.; MK7009 Placebo
Other intervention name(s): MK7009
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Influence of Antipruritics on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin.
Condition: Pruritus
MeSH terms: Pruritus
Study type: Interventional

Summary: 
      In order to validate the accuracy and reliability of the histamine skin prick model for
      histaminergic itch and vasodilation, the dermal blood flow response induced by a histamine
      skin prick will be evaluated after the administration of certain antipruritics. Besides, the
      influence of these antipruritics on the dermal blood flow response induced by the topical
      application of cinnamaldehyde and capsaicin will be evaluated. Changes in dermal blood flow
      will be measured with laser speckle contrast imaging.
    


Intervention name(s): Desloratadine 5 mg; Aprepitant 125 mg; Ketotifen 1 MG
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Desloratadine (H1-antihistamine): oral tablet (1 x 5 mg), taken with 240 ml water, 4 hours prior to the histamine skin prick; Aprepitant (NK1-antagonist): hard capsule (1 x 125 mg), taken with 240 ml water, 4 hours prior to the histamine skin prick; Ketotifen (H1-antihistamine and mast cell stabilizer): capsule (1 x 1 mg), taken with 240 ml water, 4 hours prior to the histamine skin prick
Intervention MeSH terms: Ketotifen; Aprepitant; Desloratadine
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Randomized, double-blind, cross-over study
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
A Study to Compare the Safety, Pharmacokinetics and Pharmacodynamics of YPI 011 to Rabeprazole in Healthy Adult Subjects
Condition: Gastroesophageal Reflux Disease
MeSH terms: Gastroesophageal Reflux
Study type: Interventional
Phase: Phase 1

Summary: 
      A study to compare the safety, pharmacokinetics and pharmacodynamics of YPI 011 to
      Rabeprazole in healthy adult subjects
    

Detailed description: 
      This study is to compare the safety, pharmacokinetics and pharmacodynamics of YPI 011 to
      Rabeprazole in healthy adult subjects
    

Intervention name(s): Rabeprazole Sodium 10mg; Rabeprazole Sodium 20mg
Intervention type(s): Drug; Drug
Intervention description(s): Part A: 1 tablet administered before the breakfast during 7 days; Part B: 1 tablet administered before the breakfast during 7 days
Other intervention name(s): Reference drug; Reference drug
Intervention MeSH terms: Rabeprazole
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Evaluation of Some Parameters in University Students During the COVİD-19 Epidemic Process
Condition: Health Behavior; Sleep; Body Weight
MeSH terms: Body Weight
Study type: Observational

Summary: 
      The physical and mental effects of the COVID-19 pandemic have been examined by many
      researchers, but our study aims to evaluate in every aspect how university students who had
      to receive education with the distance education model due to the pandemic went through this
      process. Data regarding people's positive and negative habits from anthropometric
      characteristics and sleep quality, which is one of the sub-dimensions of healthy lifestyle
      behaviors, were evaluated, and the relationship between these parameters was examined in
      detail.
    

Detailed description: 
      Our study focuses on distance education, remote working, etc. during the pandemic period. It
      is compatible with the findings of studies on the subject and reveals that the nutrition and
      physical activity sub-parameters of the healthy lifestyle behaviors scale are related to
      anthropometric characteristics and sleep quality. Considering that the online working model
      has become widespread, from this perspective, for future studies, the effects of behavioral
      change strategies on individuals' sleep quality and anthropometric values can be
      investigated.
    

Intervention name(s): Evaluation form
Intervention type(s): Other
Intervention description(s): This form is a form of demographic information, questions that question the habits of COVİD-19 era, and evaluation scales.
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Students registered to Kırklareli University Faculty of Health Sciences and attending
        distance education due to COVID-19 pandema
Study of VX-765 in Subjects With Treatment-resistant Partial Epilepsy
Condition: Partial Epilepsy
MeSH terms: Epilepsy; Epilepsies, Partial
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine the safety, tolerability, and efficacy of VX-765 in
      subjects with Treatment-resistant Partial Epilepsy
    


Intervention name(s): VX-765
Intervention type(s): Drug
Intervention description(s): 300mg Oral Tablet, 900mg TID
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Effect of Attention Training or SSRIs on Symptoms and Neural Activation in Social Anxiety
Condition: Social Anxiety Disorder
MeSH terms: Anxiety Disorders; Phobia, Social
Study type: Interventional

Summary: 
      The purpose of this study is to determine the clinical efficacy and neuro-cognitive
      mechanisms of Gaze-Contingent Usic Reward Therapy for social anxiety disorder, compared with
      treatment with SSRIs or waitlist control.
    

Detailed description: 
      Attention biases in threat processing have been assigned a prominent role in the etiology and
      maintenance of anxiety disorders. The purpose of this study is to determine whether giving
      gaze-contingent feedback is an effective treatment for social anxiety disorder, compared to
      treatment with SSRI (Escitelopram) and a waitlist control. A secondary purpose is to explore
      the unique neuro-cognitive mechanisms of this treatment, using eye-tracking, MRI and fMRI
      measurements. Participants will be assessed using clinical interviews and self-rated
      questionnaires before, during and after 12 weeks of treatment or wait. Outcome measures will
      be social anxiety symptoms, as well as dwell time on threat in eye-tracking paradigms tested
      in previous studies, and BOLD signals in MRI measurements. Neuro-cognitive mechanisms will be
      explored as potential mediators of clinical efficacy.
    

Intervention name(s): Gaze Contingent Music Reward Therapy; Escitalopram; Waitlist
Intervention type(s): Behavioral; Drug; Behavioral
Intervention description(s): Feedback according to participants' viewing patterns, in order to modify their attention.; 10-20 mg of Escitalopram; Participants will wait for 12 weeks while in touch with the clinic, then receive GC-MRT for 8 weeks.
Other intervention name(s): Cipralex
Intervention MeSH terms: Escitalopram
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Study of Ipragliflozin in Patients With Type 2 Diabetes Mellitus Receiving Insulin Therapy
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 4

Summary: 
      The objective of this study is to assess the reduction in insulin dose from baseline at Week
      24 while keeping the blood glucose levels controlled (maintaining HbA1c values) when
      ipragliflozin is administered once daily for 24 weeks in patients with type 2 diabetes
      mellitus receiving insulin therapy.
    


Intervention name(s): Ipragliflozin; Insulin
Intervention type(s): Drug; Drug
Intervention description(s): Oral administration, 50mg once daily; Patients are receiving insulin therapy from at least 12 weeks before Visit 1 (is allowed ±10% dose modification if clinically needed, and is reduced within a 20% to 40% range at Visit 1 and then is controlled up to Visit 8 based on criteria of this study).
Other intervention name(s): ASP1941; Suglat
Intervention MeSH terms: Ipragliflozin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Ipragliflozin; SGLT2 inhibitor; Type 2 diabetes mellitus; ASP1941
A Phase 1 Study To Estimate The Relative Bioavailability Of Fixed Combination Tablets Of Azithromycin And Chloroquine Compared To Co-Administered Individual Tablets Of Azithromycin And Chloroquine
Condition: Malaria
MeSH terms: Malaria
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective is to estimate the relative bioavailability of fixed azithromycin /
      chloroquine combination tablets relative to co-administered individual tablets of
      azithromycin and chloroquine.
    


Intervention name(s): Fixed combination of Azithromycin and Chloroquine; Azithromycin and Chloroquine
Intervention type(s): Drug; Drug
Intervention description(s): Pfizer will provide the study medications, fixed combination azithromycin/chloroquine tablets (250 mg/155 mg, base), The study treatment is single dose.; Pfizer will provide Zithromax (500 mg) and Aralen (500 mg containing 300 mg chloroquine base). The study treatment is single dose.
Intervention MeSH terms: Azithromycin; Chloroquine; Chloroquine diphosphate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Bioavailability
Biobehavioral Mechanisms of Blood Pressure Regulation
Condition: Cardiovascular Diseases; Heart Diseases; Hypertension
MeSH terms: Cardiovascular Diseases; Heart Diseases
Study type: Observational

Summary: 
      To investigate the role of biobehavioral factors in the pathogenesis of concentric left
      ventricular hypertrophy.
    

Detailed description: 
      BACKGROUND:

      Hypertension is more prevalent in Black than white men, and is more prevalent in men than
      women. Furthermore, even controlling for blood pressure, concentric left ventricular
      hypertrophy, an early structural adaptation of hypertension, is more prevalent in Black than
      white men, and more prevalent in men than women. Concentric left ventricular hypertrophy is
      the strongest predictor, other than age, of the cardiovascular morbidity associated with high
      blood pressure.

      DESIGN NARRATIVE:

      In a biracial sample, concentric left ventricular hypertrophy and concentric remodelling were
      assessed by echocardiographic measures of left ventricular mass and relative wall thickness.
      Laboratory procedures were used to: (i) assess hemodynamic and neurohumoral responses during
      exposure to a diverse battery of physical and psychological stressors, and; (ii) evaluate
      alpha and beta adrenergic receptor responsiveness, baroreceptor reflex gain and minimal
      forearm vascular resistance. Since blood pressure during a typical workday was an established
      predictor of left ventricular hypertrophy, it was also assessed. A new biobehavioral model
      was tested that implicated the hemodynamic pattern of behaviorally-evoked pressor responses
      in the pathogenesis of concentric left ventricular hypertrophy. One prediction of this model
      was that a predisposition to exhibit increased vascular resistance during stress
      (characteristic of black men) would favor the development of concentric hypertrophy. Thus,
      systemic vascular resistance responses, evaluated in the laboratory, were hypothesized to
      independently predict left ventricular mass and relative wall thickness, even after
      controlling for established risk factors, including workday blood pressure. Sympathetic
      nervous system function was examined to test hypothesized mechanisms responsible for race and
      gender differences in the hemodynamic patterns of blood pressure regulation. The results of
      these studies emphasized the importance of race and gender in prescribing pharmacological
      and/or behavioral treatment for hypertensive heart disease.

      The study completion date listed in this record was obtained from the "End Date" entered in
      the Protocol Registration and Results System (PRS) record.