Milk Biofortification Promotes Health Benefits in Institutionalized Elderly
Condition: Nutrient Deficiency; Age-Related Immunodeficiency; Vitamin E Deficiency; Selenium Deficiency; Fatty Acid Deficiency; Institutionalization; Disinhibited Attachment
MeSH terms: Vitamin E Deficiency
Study type: Interventional

Summary: 
      The project aims to study the effects of inclusion of sunflower oil, vitamin E and selenium
      in the diet of dairy cows on milk composition and the influence of modified milk on nutrition
      and health of elderly. To achieve those goals, two experiments will be conducted, both
      lasting 12 weeks. In the first one, 32 cows at the beginning of lactation will be allotted in
      a completely randomized block design with a 2 x 2 factorial arrangement of treatments, as
      follow: 1) control diet; 2) control diet plus selenium and vitamin E; 3) control diet plus
      sunflower oil diet; 4) control diet plus sunflower oil, selenium and vitamin E. This
      experiment seeks the development of modified milks through nutritional manipulation of cow's
      diet. Concomitantly, in the second experiment, 132 elderly people will receive the four
      different kinds of milk produced in the first experiment in a completely randomized block
      (gender) design. The selection of the elderly for each group shall be composed clinical
      evaluations. Will be conducted biochemical tests before and after supplementation of milk
      consumption (serum α-tocopherol, selenium, analysis of fatty acid profile). Assessment of
      nutritional status will be made body mass index (BMI) with each participant before and after
      the experiment of 12 weeks, including body composition by multifrequency bioelectrical
      impedance analysis (BIA), evaluating the strength of pressure of the hand portable
      dynamometer, demographics and food consumption. The study of human nutrition and health will
      be held in the form of a double-blind study. The second experiment aims to study nutrition
      and health of elderly people, as it is expected that milk produced with better fatty acid
      profile, vitamin and minerals can improve the inflammatory profile of markers of the elderly.
      This project is important for the human population in general, particularly elderly people,
      health workers, human and animal nutritionists, and especially for the milk chain, as it has
      a potential to develop new dairy products and boost milk consumption.
    


Intervention name(s): Milk Antioxidant group(A); Milk Oil group(O); Milk Antioxidant and oil(AO); Milk Control group(C)
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): There is no intervention pre-specified before the institutionalized elderly to receive three times per day of milk (total 600ml of milk all day) produced by lactating cows fed with the following diets: control (C)+selenium and vitamin E (A).; There is no intervention pre-specified before the institutionalized elderly to receive three times per day of milk (total 600ml of milk all day) produced by lactating cows fed with the following diets: control (C)+sunflower oil (O).; There is no intervention pre-specified before the institutionalized elderly to receive three times per day of milk (total 600ml of milk all day) produced by lactating cows fed with the following diets:control (C)+selenium, vitamin E and sunflower oil (AO).; There is no intervention pre-specified before the institutionalized elderly to receive three times per day of milk (total 600ml of milk all day) produced by lactating cows fed with the following diets: control (C)
Other intervention name(s): add control diet(C) in the cow's food; add selenium in the cow's food; add vitamin E in the cow's food; add control diet(C) in the cow's food; add sunflower oil group in the cow's food; add control diet(C) in the cow's food; add selenium in the cow's food; add vitamin E in the cow's food; add sunflower oil in the cow's food; add control diet (C) in the cow's food; without vitamin E in the cow's food; without selenium in the cow's food; without sunflower oil in the cow's food
Intervention MeSH terms: Vitamins; Vitamin E; Tocopherols; Tocotrienols; alpha-Tocopherol; Selenium; Antioxidants
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
Keywords: aging; nutrients; milk; dietary supplementation