bioihbjkbjnl/mcl2 huggingface dataset:
Return to Work With Post Stroke Communication Disorders
Condition: Stroke
MeSH terms: Stroke; Communication Disorders
Study type: Observational

Summary: 
      Approximately a quarter of stroke survivors are of working age, and it is well-known that
      disabilities caused by stroke can lead to difficulties returning to work. In addition to the
      economic cost, being out of the workplace due to disability has major psychosocial costs for
      the individual, causing reduced sense of purpose, quality of life, and standard of living.
      Communication problems (which can affect reading and writing, as well as producing and
      understanding speech) are not as visible as other stroke-related problems such as a weak arm
      or difficulties walking. However, they can cause major problems for returning to work because
      of the importance of communication across a vast range of work activities, for example as a
      means to engage with colleagues, to share information in order to solve problems and resolve
      conflicts, and as a means to ensure health and safety. There has been little research into
      the effects of communication problems on returning to work after a stroke, so the
      investigators want to explore this issue. Specifically, the investigators want to find out
      what helps and what hinders people with communication disorders following a stroke when they
      attempt to return to work; what information and support is most helpful to them; how this
      information and support should be given and by whom. The investigators aim to do this by
      interviewing people across NHS Grampian who have the experience of attempting to return to
      work with post-stroke communication problems. The investigators will then look at all the
      interviews together and find the common feelings or experiences that the participants
      mentioned. The findings will be written up and shared widely with professionals and with
      stroke survivors. The knowledge gained will help the investigators to plan a programme to
      help people with these problems to return to work.
    


Intervention name(s): Not applicable- no intervention administered
Intervention type(s): Other
Intervention description(s): Not applicable- no intervention administered
Observational model: Other
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        Adults (aged 18 years of age and over) who have post-stroke communication disorders, and
        who have attempted or are attempting to return to paid employment.
Double-Blind, Dose-Escalation Study of IDX184 in Chronic Hepatitis C Treatment-Naïve Subjects
Condition: Chronic Hepatitis C (HCV)
MeSH terms: Hepatitis A; Hepatitis C; Hepatitis C, Chronic; Hepatitis; Hepatitis, Chronic
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This is a proof-of-concept study which will provide data about the safety and antiviral
      activity of several doses of the investigational drug IDX184 given for 3 days in
      treatment-naive HCV genotype 1-infected subjects so that optimal doses can be chosen for
      testing in later studies.
    


Intervention name(s): IDX184
Intervention type(s): Drug
Intervention description(s): oral dose, active or placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Hepatitis C, HCV, treatment-naive
Work-related Musculoskeletal System Disorders Among Female Workers in Hazelnut Factory
Condition: Musculoskeletal Strain; Pain; Occupational Problems; Work-related Injury
MeSH terms: Musculoskeletal Diseases
Study type: Observational

Summary: 
      The aim of this study is to determine the prevalence of work-related musculoskeletal
      disorders in female workers in hazelnut factory. The secondary aim is to investigate the
      relationship between the musculoskeletal disorders severity and working posture, work related
      factor, psychosocial factor.
    


Intervention name(s): Investigation of the work-related musculoskeletal disorders
Intervention type(s): Diagnostic Test
Intervention description(s): Structured questionnaires will be used to determine the prevalence of the work-related musculoskeletal disorders and work-related factor. Photogrammetric method will be used to evaluate working posture.
Observational model: Case-Crossover
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        The population of this study involved the female workers of a hazelnut factory.
      
Keywords: work-related musculoskeletal disorders; hazelnut factory; low back pain; neck pain
Mechanisms of Mindfulness for Smoking Cessation
Condition: Smoking Cessation
Study type: Interventional

Summary: 
      The purpose of this study is to understand brain mechanisms of app-based mindfulness training
      in smokers ages 21 to 65 years.
    


Intervention name(s): App/Training; App/Training; Smartphone
Intervention type(s): Behavioral; Behavioral; Device
Intervention description(s): This is a free smoking cessation smartphone app using the latest evidence-based smoking cessation methods and behavior change theory. The app allows users to set a quit date, financial goals, and reminders, track daily smoking habits with an easy-to-use calendar, see graphs tracking money saved and number of packs not smoked, receive health milestones and craving tips to stay motivated, connect with social networks to give milestone updates, create a video diary, and watch personalized video messages from loved ones; It is comprised of twenty-two modules of 10-15 minutes each, designed to teach mindfulness for smoking cessation using psychoeducation-based audio and videos, animations to reinforce key concepts, and in vivo exercises. In addition, 5 bonus modules become available upon completion of earlier modules; these may be accessed for additional practices to bolster other modules.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Effect of SSP-004184 (SPD602) on the Pharmacokinetics of Simvastatin in Healthy Adult Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a randomized, open-label study to evaluate the effect of a single dose of SSP-004184
      on the pharmacokinetics of a single dose of simvastatin in healthy adult subjects.
    


Intervention name(s): Simvastatin; SSP-004184SS
Intervention type(s): Drug; Drug
Other intervention name(s): SPD602
Intervention MeSH terms: Simvastatin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Other
Flow Controlled Ventilation in Thoracic Surgery
Condition: Positive-Pressure Respiration, Intrinsic
MeSH terms: Positive-Pressure Respiration, Intrinsic
Study type: Interventional

Summary: 
      This trial investigates effects of individualized (by compliance guided pressure settings)
      flow-controlled ventilation compared to best clinical practice pressure-controlled
      ventilation in thoracic surgery requiring one lung ventilation.
    

Detailed description: 
      Flow-controlled ventilation (FCV) is a novel ventilation method with promising first results
      in porcine studies as well as clinical trials. A more efficient and maybe lung protective
      ventilation strategy would be crucial in the challenging situation of one lung ventilation
      during thoracic surgery, when the whole gas exchange has to be provided by just one half of
      the lungs. It could not only improve respiratory values, but also decrease the incidence of
      postoperative pulmonary complications, which is a major cause of death after thoracic
      surgery.

      Thus, individualized FCV, based on compliance guided pressure settings, will be compared to
      best clinical practice pressure-controlled ventilation in thoracic surgery requiring one lung
      ventilation in a randomized controlled trial. Based on a previous preclinical trial improved
      oxygenation will be expected and thus arterial partial pressure of oxygen (pO2) is the main
      primary outcome parameter of this study. Furthermore, improved recruitment of lung tissue due
      to controlled expiratory flow in FCV will be anticipated without the need of recruitment
      maneuvers, which may cause deleterious effects on lung tissue.
    

Intervention name(s): Evone; Primus
Intervention type(s): Device; Device
Intervention description(s): Airway ventilation device; Airway ventilation device
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: controlled, prospective
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: flow controlled ventilation; pressure controlled ventilation; thoracic surgery; one lung ventilation
Neuromuscular Electrical Stimulation in Patients With Interstitial Lung Disease
Condition: Interstitial Lung Disease
MeSH terms: Lung Diseases; Lung Diseases, Interstitial
Study type: Interventional

Summary: 
      Decreased exercise capacity and quality of life, increased dyspnea and fatigue perception and
      hypoxemia during exercise is seen in patients with interstitial lung disease. Impaired
      ventilatory response, increased lung compliance, ventilation-perfusion mismatching and
      inadequate peripheral circulation causes decreased exercise capacity. Another important
      factor that induce decreased exercise capacity is peripheral muscle weakness. In literature,
      there is no study investigated effects of neuromuscular electrical stimulation on functional
      exercise capacity, respiratory and peripheral muscle strength, pulmonary functions, physical
      activity level, dyspnea and fatigue perception in patients with interstitial lung disease.
    

Detailed description: 
      In literature, there was increased quantity of study investigated effects of neuromuscular
      electrical stimulation in chronic lung disease patients. It was used as a pulmonary
      rehabilitation component especially in patients with decreased exercise capacity and
      peripheral muscle strength, intensely increased dyspnea inhibits exercise. It was
      demonstrated that neuromuscular electrical stimulation improved functional exercise capacity,
      peripheral muscle strength and quality of life.
    

Intervention name(s): NMES Group; Control Group
Intervention type(s): Other; Other
Intervention description(s): Neuromuscular electrical stimulation; Breathing exercises
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: interstitial lung disease; neuromuscular electrical stimulation; exercise capacity; quality of life
Endothelial Microparticles: A Novel Marker of Vascular Dysfunction
Condition: Chronic Kidney Disease
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic
Study type: Observational [Patient Registry]

Summary: 
      The primary hypothesis of this proposal is that chronic kidney disease (CKD) and treatment
      with calcineurin inhibitors (CNIs) are each associated with the release of endothelial
      microparticles into the plasma.
    

Detailed description: 
      The primary hypothesis of this proposal is that chronic kidney disease (CKD) and treatment
      with calcineurin inhibitors (CNIs) are each associated with the release of endothelial
      microparticles into the plasma. These injury-associated microparticles have a different
      molecular/protein composition than those released from endothelial cells in healthy patients,
      and their abundance correlates with vascular injury. To test this hypothesis the
      investigators propose a 3 arm case-controlled study including normal controls, individuals
      with stage III and IV CKD not receiving CNI therapy, and individuals with stage III and IV
      CKD post kidney transplantation receiving a CNI. The goal of this study is to measure the
      amount of microparticles in patients with kidney disease who have had a kidney transplant.
      Another goal of this study is to see if the measurements of microparticles are related to
      poor function of the vessels (endothelial dysfunction).
    

Intervention name(s): Flow-mediated dilation; single blood draw
Intervention type(s): Other; Other
Intervention description(s): Flow-mediated dilation used to measure vascular function. The test is minimally invasive, with only a slight discomfort due to the inflation of the arm cuff.; single blood draw of approximately 45 mL.
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        90 volunteers from the Anschutz Medical Campus
      
Biospecimen description: 
      plasma and urine biospecimens to be retained.
Lowering Blood Pressure in Primary Care in Vienna
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional
Phase: Phase 4

Summary: 
      The aim of this prospective, randomised, open-label, multicentre clinical trial is to enhance
      blood pressure control in primary care by introducing a standardised and simplified titration
      regime with single pill combinations (SPC), comprising an angiotensin receptor blocker,
      calcium channel blocker and hydrochlorothiazide.
    

Detailed description: 
      Rationale Hypertension is the single largest contributor to mortality worldwide, accounting
      for 13% of deaths globally. Approximately 30% of the adult population suffer from
      hypertension and of those diagnosed and treated, only 30-50% have adequately controlled blood
      pressure. At present, the importance of hypertension as fundamental risk factors is
      inadequately addressed among many patients and physicians.

      Design The aim of this prospective, randomised, open-label, multicentre clinical trial is to
      enhance blood pressure control in primary care by introducing a standardised and simplified
      titration regime with single pill combinations (SPC), comprising an angiotensin receptor
      blocker, calcium channel blocker and hydrochlorothiazide.

      The trial will randomise 42 family doctors or resident specialists for internal medicine
      (enrolling 840 patients with treated or untreated hypertension) to either experimental care
      or standard care for hypertension, latter according to the 2013 European Society of
      Cardiology Guidelines for the Management of Arterial Hypertension.

      Practitioners randomised to experimental care will up-titrate antihypertensive therapy with
      SPCs in 4-week intervals if the target blood pressure of < 140/90 mmHg is not reached at the
      respective follow-up (Figure 1).

      Study Outcomes The primary efficacy endpoint will be the proportion of patients achieving the
      target office blood pressure after 6 months of follow-up. The main secondary endpoint will be
      the improvement of 24h ambulatory blood pressure (ABPM) profile, measured at inclusion and
      after 6 months of follow-up.

      Safety assessments include the evaluation of treatment emergent adverse events, particularly
      hospitalisation, worsening of renal function, peripheral oedema and hypotension.
    

Intervention name(s): Olmesartan medoxomil, amlodipine, hydrochlorothiazide
Intervention type(s): Drug
Intervention description(s): Up-titration of antihypertensive therapy with single pill combinations (comprising an angiotensin receptor blocker, calcium channel blocker and hydrochlorothiazide) in 4-week intervals if the target blood pressure of < 140/90 mmHg is not reached at the respective follow-up
Intervention MeSH terms: Amlodipine; Hydrochlorothiazide; Olmesartan; Olmesartan Medoxomil
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Imaging of 3D Innervation Zone Distribution in Spastic Muscles From High-density Surface EMG Recordings
Condition: Spasticity
MeSH terms: Muscle Spasticity
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to evaluate if it is possible to use a new 3D imaging method to
      guide Botulinum neurotoxin (BTX) injection for muscle spasticity management after stroke.
      This imaging method is called three dimensional innervation zone imaging, or 3DIZI.
    


Intervention name(s): Botulinum neurotoxin (BTX); Physical Therapy; Standard BTX injection (ultrasound guided); 3-dimensional innervation zone (3DIZ) guided injection
Intervention type(s): Drug; Other; Device; Device
Intervention description(s): Each patient will receive BTX injections in 2 sites. 100 units at double dilution will be injected at each site.; Standard physical therapy will be ordered to both groups as part of standard of care for patients after BTX injections to maximize the outcomes.; For standard injection procedures, target muscles will be visualized under ultrasound imaging which is operated by an experienced and dedicated technician. Position of needle tip within the target muscle is visualized prior to injection. Ultrasound guidance can help ensure depth of needle tip location, i.e., to make sure the needle tip is within the muscle, but it is not able to tell where it is located with reference to the innervation zones (IZs) of the entire muscle.; Simultaneous surface EMG and intramuscular EMG measurements will be acquired from the spastic biceps of the patients. Patients will be seated comfortably on a height-adjustable chair. The arm to be tested will be secured firmly on a customized apparatus with the elbow joint at approximately 90° of flexion and the shoulder at approximately 45° of abduction and 30° of flexion. The 128-channel unipolar surface EMG signals will be recorded with 2 flexible 2-dimensional 64-channel surface electrode array. A coating fine wire electrode will be inserted into the mid-axial section of the biceps to record bipolar intramuscular EMG signals. Ultrasound scan will be performed on the biceps to identify the location of the inserted wire electrode. Patients will be asked to contract their impaired biceps to perform maximum voluntary contraction of elbow flexion against the vertical plates 3 times.
Other intervention name(s): Botox
Intervention MeSH terms: Botulinum Toxins
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: stroke
Supporting Decisions About Health Insurance to Improve Care for the Uninsured
Condition: Health Literacy; Health Insurance; Health Services Accessibility; Informed Decision Making
Study type: Interventional

Summary: 
      The overall purpose of the study is to better understand how the investigators previously
      developed decision support (DS) tool can help people make decisions about health insurance
      plans available through the federal exchanges created by the Affordable Care Act (ACA). The
      investigators will evaluate the DS tool compared to the federal government website. The
      investigators will also evaluate the feasibility of disseminating this tool. There are two
      primary aims to be completed in this project: (1) examine the reach and effectiveness of the
      health insurance DS tool; and (2) collect stakeholders' feedback to improve the likelihood of
      implementation of the DS tool.
    

Detailed description: 
      First, for Aim 1 part 1, the investigators will recruit 40 key stakeholders (uninsured
      participants, health providers, community advisors, and health policy experts) to refine the
      DS tool through a series of individual semi-structured interviews. Next, the investigators
      will use their feedback to program the DS strategies into an online DS tool. After its
      initial production, the tool will be pilot tested with 30 individuals to assess readability,
      message clarity, format, and function of the tool as well as to test the randomized trial
      study procedures. Then, for Aim 1 part 2, the investigators will test the DS tool in a
      randomized trial with 362 participants eligible for the Affordable Care Act (ACA) exchanges.
      Half will use the DS tool and the other half will use the federal government site to learn
      about the exchanges. The investigators will use computerized random assignment to assign
      participants to study condition, after which they will all complete the same short survey.
      For Aim 2, the investigators will collect 40 stakeholders' feedback on likelihood of adoption
      and implementation of the DS tool to plan for dissemination and implementation. Stakeholders
      will be asked both open-ended and closed-ended questions in order to gather feedback about
      delivering the DS tool. These stakeholders will be different from those who were interviewed
      in Aim 1 as to ensure broader applicability of the DS tool.
    

Intervention name(s): Decision Aid (DA)
Intervention type(s): Behavioral
Intervention description(s): Participants will be shown (on a computer) a targeted, web-based decision aid focused on the topic of health insurance plans in addition to usual care.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Health insurance; Health services accessibility; Decision making; Health literacy