2D-speckle Tracking in Pediatric Renal Chronic Disease
Condition: Chronic Renal Disease; Chronic Renal Insufficiency; Congenital Heart Disease
MeSH terms: Kidney Diseases; Renal Insufficiency; Renal Insufficiency, Chronic; Kidney Failure, Chronic; Heart Diseases; Heart Defects, Congenital
Study type: Observational

Summary: 
      The SPECKLE- KIDNEY-PED is a multicentre observational controlled trial aiming to evaluate
      the 2D-Speckle tracking in a population of 85 patients aged from 6 to 17 years old with a
      chronic renal disease and to compare the results to those of 85 age and gender-matched
      healthy subjects. The secondary objective is to assess the conventional echocardiographic
      parameters and the level of exercice capacity.
    

Detailed description: 
      Kidney disease and chronic kidney failure are one of the most common causes of chronic
      childhood disease. They are often complicated by cardiovascular disease, which can, in the
      long run, affect patients' prognosis. Thus, mortality in children undergoing hemodialysis for
      end-stage kidney failure is related in more than 30% of cases to a cardiovascular
      complication. An annual cardiac assessment is recommended as part of the follow-up of these
      patients to assess the cardiac impact of kidney disease (high blood pressure, hyper-uremia,
      etc.). The use of conventional cardiological assessment parameters does not predict the
      cardiovascular prognosis of patients because the alteration of these parameters is greatly
      delayed in the course of the disease. 2D strain or "speckle tracking echocardiography" is a
      non-invasive ultrasound technique that allows for a more sensitive assessment of myocardial
      tissue damage and its early impairment has been shown as a factor of poor prognosis in other
      pediatric chronic pathology (neuromuscular disease, cardiotoxic exposure, etc.) as well as in
      adult chronic kidney failure.

      The SPECKLE- KIDNEY-PED trial is a multicentre observationnal controlled study. The main
      objective of this work is to asses the 2D strain ventricular function in children with kidney
      failure, to compare it with that of healthy children of 6 to 17 years old, and to correlate
      it with the cardio-renal severity of the disease in terms of level of kidney failure and
      aerobic physical fitness.

      The secondary objective is to assess, in this population, the level of exercice capacity and
      to compare it to the general population of children of the same age.

      A total of 180 children are recquired to observe a significant difference of 2,5% of the
      global strain value with a power of 90% and an alpha risk of 5%.

      The SPECKLE- KIDNEY-PED trial intends to improve the level of evidence for future guidelines
      on cardiologic survey and promotion of physical activity in this population
    

Intervention name(s): Observational study
Intervention type(s): Other
Intervention description(s): Observational study
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Cases group : Children aged 6 to 17years old with chronic renal insufficiency

        Control group: Children aged 6 to 17 years old with normal check up
      
Keywords: Speckle-tracking; Exercice capacity; Cardiovascular prognosis