bioihbjkbjnl/mcl2 huggingface dataset:
Optimized Camera-based Patient Positioning in CT
Condition: Radiation Dosage
Study type: Observational

Summary: 
      To evaluate the effect on radiation dose using intelligent camera positioning in comparison
      to manual positioning by the radiology assistant.
    

Detailed description: 
      The positioning of the patient at the beginning of every CT examination has an major
      influence on the image quality and especially on the respective effective patient dose in the
      CT scan. If the patient position is closer to the X-ray tube, the patient dose increases
      significantly and if the vertical patient position is chosen too far away from the X-ray
      tube, the applied dose decreases, but also the image quality.

      In a retrospective observational study, patients were examined on the CT scanner Somatom
      X.Cite and divided into two groups, one group was with intelligent camera positioning and the
      other with manual positioning.

      The patients received their CT scan at the Institute Radiology and Nuclear Medicine at the
      Nuremberg North Hospital strictly according to the clinical indication and without influence
      of the study.
    

Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        patients of a primary care clinic
Effects of Transdermal Scopolamine on Occupational Performance
Condition: Motion Sickness
MeSH terms: Motion Sickness
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine the effects of Transdermal scopolamine vs. placebo
      on ship navigation performance under simulated heavy sea conditions.
    

Detailed description: 
      Our study proposes to use a randomized crossover placebo controlled design to test the
      effects of transdermal scopolamine vs. placebo on simulated ship navigation performance under
      conditions of heavy seas. We hypothesize that mariners will experience a greater decrement in
      navigational performance in the placebo condition vs. transdermal scopolamine, when faced
      with simulated heavy seas. Study staff will apply the transdermal scopolamine patch or
      placebo patch, 8 hours prior to performance assessment. Participants will surrender car keys
      and will agree stay on the Kalmar Maritime Campus until they are dismissed from the study. A
      study nurse and/or study physician will be on call from the time of patch application until
      study participants are dismissed from the study. Eight hours following patch application
      participants will perform navigation tasks, under stormy weather conditions, in the bridge
      simulation lab at Kalmar Maritime Academy. Participants will repeat the protocol one week
      later under the opposite dosing condition. This study will be conducted at the Kalmar
      Maritime Academy, Kalmar, Sweden.
    

Intervention name(s): Scopolamine
Intervention type(s): Drug
Intervention MeSH terms: Scopolamine; Butylscopolammonium Bromide
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double
Primary purpose: Prevention
Keywords: Scopolamine; Antiemetic; Task performance and analysis; Psychomotor vigilance test
Calcium and Vitamin D to Optimize Bone Mass in Boys With Risperidone-induced Hyperprolactinemia
Condition: Risperidone-induced Hyperprolactinemia
MeSH terms: Hyperprolactinemia
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to determine whether calcium and vitamin D supplementation, over
      a nine-month period, optimizes bone mineralization in boys with risperidone-induced
      hyperprolactinemia. We hypothesize that, by the end of the stuy, children in the
      supplementation group will have higher bone mineral density compared to those in the placebo
      group.
    


Intervention name(s): Calcium and Vitamin D; Placebo
Intervention type(s): Drug; Other
Intervention description(s): Calcium carbonate 625mg and vitamin D 200IU will be administered, orally, twice a day for a nine-month period.
Other intervention name(s): Ca+VitD
Intervention MeSH terms: Vitamin D; Calcium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Risperidone; hyperprolactinemia; children; adolescents; antipsychotics; prevention; calcium; vitamin D; Risperidone-induced hyperprolactinemia
Human Rabies Immunoglobulin (HRIG)- Dosage Determination and Interference With the Active Immune Response
Condition: Rabies
MeSH terms: Rabies
Study type: Interventional

Summary: 
      Dosage of rabies immune globulin was calculated from the victim's body weight, then the
      amount of rabies immune globulin would be injected as much as possible to all of the wounds.
      Increase dosage of rabies immune globulin was needed in situation of multiple severe
      bite-wounds especially among children whose had lower body weight than adults. Our study
      would be conducted in order to determine whether the increase dosage of rabies immune
      globulin would interfere with the protective antibody levels against rabies.
    

Detailed description: 
      -  Controlled trial study.

        -  All 50 volunteers who had never had rabies immunization would be enrolled and designated
           into 2 groups.

      group 1 : 15 Healthy volunteers age 18 - 60 yr who were attacked by mammals, possible exposed
      to rabies and had WHO category III exposure, all receive standard post - exposure rabies
      treatment with 5-dose intramuscular rabies vaccine on day 0,3,7,14,28 and 20 IU/kg of human
      rabies immune globulin (HRIG).

      group 2 : 35 Healthy volunteers age 18 - 60 yr receive 5-dose intramuscular rabies vaccine on
      day 0,3,7,14,28 and 40 IU/kg of human rabies immune globulin (HRIG).

      5 cc - Blood would be drawn from all volunteers before vaccination and on day 14, 28 and 90
      for rabies neutralizing antibody titers (RNab).

      The GMTs of RNab among both groups would be analyzed and compared.
    

Intervention name(s): Human Rabies Immune Globulin
Intervention type(s): Biological
Intervention description(s): HRIG 20 IU/kg and 40 IU/kg would be given once to the volunteers on day 0
Other intervention name(s): Human Rabies Immune Globulin produced by Thai Red Cross
Intervention MeSH terms: Immunoglobulins; Antibodies; gamma-Globulins; Immunoglobulins, Intravenous; Rho(D) Immune Globulin; Immunoglobulin G
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: rabies; immunoglobulin; dosage
99mTc-HPArk2 SPECT/CT for the Detection of HER2-positive Breast Cancer
Condition: Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Interventional
Phase: Early Phase 1

Summary: 
      This is an open-label single photon emission tomography/computed tomography (SPECT/CT) study
      to investigate the diagnostic performance and evaluation efficacy of 99mTc-HPArk2 in breast
      cancer patients. A single dose of 11.1Mega-Becquerel (MBq) per kilogram body weight
      99mTc-HPArk2 will be injected intravenously. Visual and semiquantitative method will be used
      to assess the SPECT/CT images.
    

Detailed description: 
      99mTc-HPArk2 is an affibody probe targeting HER2. The investigators will determine the use of
      99mTc-HPArk2 SPECT/CT in the detection of HER2-positive breast cancer, and to compare its
      diagnostic value with routine immunohistochemistry (IHC) pathological staining. HER2 imaging,
      specifically to HER2 receptor expressed on malignant breast cancer cell surface, might help
      for targeted therapy with monoclonal antibody such as trastuzumab in breast cancer, and may
      improve the treatment strategy of breast cancer. The investigator will determine the use of
      99mTc-HPArk2 SPECT/CT in stratifying breast cancer.
    

Intervention name(s): 99mTc-HPArk2
Intervention type(s): Drug
Intervention description(s): 99mTc-HPArk2 were injected into the patients before the SPECT/CT scans
Other intervention name(s): 99mTc labelled HER2 affibody
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: SPECT/CT; HER2 imaging
Development of Countermeasures Against Adverse Metabolic Effects of Shift Work
Condition: Circadian Dysregulation
MeSH terms: Chronobiology Disorders
Study type: Interventional

Summary: 
      The goal of this application is to determine whether changing the timing of food intake
      prevents the adverse metabolic effects of circadian misalignment.
    

Detailed description: 
      Shift work is associated with circadian misalignment and an increased risk for the
      development diabetes, obesity, and cardiovascular disease. This research will determine
      whether changing the feeding schedule can prevent metabolic alterations that can lead to the
      abovementioned disorders. This research will provide mechanistic insight and may provide a
      novel therapeutic approach against the increased risk for diabetes, obesity, and
      cardiovascular disease among shift workers.
    

Intervention name(s): Meal schedule
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: Circadian Misalignment, Forced Desynchrony, Metabolism, Meal-timing, Circadian
A Study Evaluating the Efficacy and Safety of SM04554 Topical Solution in Male Subjects With Androgenetic Alopecia
Condition: Androgenetic Alopecia
MeSH terms: Alopecia; Alopecia Areata
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      This multi-center, randomized, double-blind, placebo-controlled study, conducted in Turkey,
      will assess the efficacy and safety of topical SM04554 solution (0.15% and 0.25%) applied
      daily to the scalp of male androgenetic alopecia (AGA) subjects.
    


Intervention name(s): Topical SM04554 solution; Topical SM04554 solution; Topical vehicle solution
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Study medication application will be performed by the individual subject at approximately the same time each day.; Study medication application will be performed by the individual subject at approximately the same time each day.; Vehicle solution application will be performed by the individual subject at approximately the same time each day.
Intervention MeSH terms: Pharmaceutical Solutions
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: male pattern baldness; SM04554; AGA
Weight Gain and Adipose Tissue
Condition: Obesity
MeSH terms: Weight Gain
Study type: Interventional

Summary: 
      This study aims to examine the role of weight gain in adipose tissue immune cell influx and
      development of obesity related cardiometabolic disorders. Adipose tissue-mediated chronic
      systemic inflammation is implicated in the development of cardiometabolic disorders in
      obesity. Therefore, resolution of adipose tissue inflammation may be key to ameliorating
      obesity-associated dyslipidemia, insulin-resistance, and cardiovascular disease.
      Proinflammatory cytokines contribute to the initial influx of immune cells into adipose
      tissue during weight gain. However, mechanisms regulating these cytokines in the adipose
      tissue milieu and the effects of weight gain on adipose tissue are not completely understood.

      The study proposes to investigate the molecular events contributing to increased infiltration
      of macrophages and T-cells into adipose tissue during weight gain. The central hypothesis is
      that in lean subjects (with low body fat mass), healthy fat gain which is associated with
      decreased expression of proinflammatory cytokines. However, in obesity (high body fat mass),
      adipose tissue is altered, which permits increased expression of inflammatory cytokines and
      further fat gain results in influx of immune cells. To test the hypothesis, adipose tissue
      from well characterized lean (control, with low body fat) and obese individuals (with high
      body fat) at baseline and after a modest 5% weight gain will be used. Adipose tissue samples
      after subsequent weight loss will also be examined.

      For this study, obesity will be defined by body composition rather than body mass index
      (BMI), as several studies have shown that BMI does not adequately define obesity and several
      individuals with normal BMI may indeed have high body fat mass. Individuals with body fat
      content ≤25% for men, & <35% for women) will be considered lean and individuals with body fat
      content >25% for men, ≥35% for women will be considered obese.
    


Intervention name(s): overfeeding induced weight gain
Intervention type(s): Behavioral
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
BRCA 1/2 Mutation in Korean Patients With Epithelial Ovarian Cancer
Condition: To Investigate the Prevalence of BRCA 1/2 Mutation Among Ovarian Cancer
MeSH terms: Ovarian Neoplasms; Carcinoma, Ovarian Epithelial
Study type: Observational

Summary: 
      PURPOSE: To investigate the prevalence and clinical correlation of the germline BRCA 1/2
      mutation in Korean patients with high grade(HG) serous and/or endometrioid epithelial ovarian
      cancer (EOC).

      PATIENTS AND METHODS: In a nationwide case-control study on EOC conducted in Korea between
      2010 and 2015, 298 Korean women with HG serous and/or endometrioid EOC were tested for gBRCA
      1/2 mutation, regardless of the family history. Mutation screening was performed using the
      Ion AmpliSeq BRCA 1/2 Panel (Life Technologies, Carlsbad, CA, USA) and Ion PGM platform
      according to the manufacturer's instructions. Clinical characteristics including survival
      outcome was assessed in gBRCAm carriers.
    


Intervention name(s): Ion AmpliSeq BRCA 1/2 Panel (Life Technologies, Carlsbad, CA, USA) ,Ion PGM platform
Intervention type(s): Genetic
Intervention description(s): BRCA1,2 Germline /Somatic mutation test
Observational model: Case-Only
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        women 18 years of age and older with previously untreated, HG serous and/or endometrioid
        EOC, fallopian tube or primary peritoneal carcinoma who consented to genetic testing
        between 2010 and 2015
Influence of Triflusal on Cognitive Functions in Healthy Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to investigate the effects of the eNOS activating agent
      triflusal on episodic memory and cognitive functions in healthy participants.
    

Detailed description: 
      Randomised, placebo controlled, double blind, cross-over design

      Primary study outcomes are:

      Performance in picturial and verbal memory tasks.

      Main secondary outcomes are: Performance in working memory and cognitive tasks and influence
      on mood, depression and anxiety and motivation.

      Once daily oral administration of placebo mannitol for 7 days in a cross-over trial with a
      washout period of at least 14 days between the two periods. Each participant will take
      triflusal as well as placebo
    

Intervention name(s): Triflusal; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Once daily oral administration of 600 mg triflusal Disgren® for 7 days.; Once daily oral administration of placebo mannitol for 7 days
Other intervention name(s): Disgren®; Mannitol
Intervention MeSH terms: Mannitol; Triflusal
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
An Open-label Extension to Evaluate the Efficacy and Safety of the Rivastigmine Transdermal Patch in Patients With Probable Alzheimer's Disease
Condition: Alzheimer's Disease
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 3

Summary: 
      The goal of this research study is to evaluate, in the open-label extension phase, the safety
      and efficacy of the rivastigmine transdermal patch in patients with probable Alzheimer's
      Disease
    


Intervention name(s): Rivastigmine Transdermal Patch
Intervention type(s): Drug
Intervention MeSH terms: Rivastigmine
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Alzheimer's disease; Dementia
A Study Of PF-04620110 As A Modified-Release Formulation In Healthy Overweight Or Obese Subjects
Condition: Healthy
MeSH terms: Overweight
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary purpose of this trial is to evaluate the safety and tolerability,
      pharmacokinetics and pharmacodynamics, of multiple oral doses of PF-04620110 as a
      modified-release formulation.
    

Detailed description: 
      To evaluate the safety and tolerability, pharmacokinetics (PK), and pharmacodynamics, of
      multiple oral doses of PF-04620110 as a modified-release formulation.
    

Intervention name(s): PF-04620110 or Placebo; PF-04620110 or Placebo; PF-04620110 or Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Multiple oral doses of 5 mg PF-04620110 as a modified-release formulation or placebo once daily for 2 weeks; Multiple oral doses of 5 mg PF-04620110 as a modified-release formulation or placebo twice daily for 2 weeks; Repeat Arm 1 or Arm 2
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Keywords: Multiple Dose Study Overweight Healthy Subjects Body Weight Modified-Release Formulation
To Investigate the Safety, Tolerability and Pharmacokinetics of AZD2516 After Multiple Dosing in Healthy Volunteers
Condition: Part A Healthy Young Males and Non-fertile Female Volunteers Aged 20 to 45 Years.; Part B Healthy Young Males and Non-fertile Female Volunteers Aged 20 to 45 and Elderly Volunteers Aged 60 to 80
Study type: Interventional
Phase: Phase 1

Summary: 
      AZD2516 is being developed for the oral treatment of chronic neuropathic pain. This study is
      split in to two parts. Part A will measure the effect of food and a new formulation of the
      drug in the blood and see how well it is tolerated. Part B will commence after the completion
      of Part A and will investigate the safety and tolerability of daily dosing with AZD2516.
    


Intervention name(s): AZD2516; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Oral, single, daily, 11 days
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: AZD2516; Phase 1; Healthy volunteer; pharmacokinetics; safety; tolerability; Multiple ascending doses
The Role of Paracetamol-caffeine and Laser Irradiation on Controlling Pain and Discomfort During Orthodontic Treatment
Condition: Pain and Discomfort; Orthodontic Appliance Complication
Study type: Interventional

Summary: 
      Patients with class I malocclusion who have mild to moderate crowding will be treated in this
      study. The efficacy of low level laser therapy and Panadol-extra® in relieving pain due to
      orthodontic treatment will be assessed. The effect of these two interventions on oral-health
      related quality of life during all stages of orthodontic treatment will be explored, i.e. at
      the following stages: (1) separation between teeth, (2) archwire changing, (3) bonding of
      brackets, (4) removal of the fixed appliances.

      There are three groups :

        1. a group of patient being irradiated with low-level laser therapy (LLLT) at specific time
           points to relieve pain and discomfort.

        2. a group of patient in which pain control will be accomplished by prescribing Panadol
           Extra tablets in a regular manner.

        3. a group of patients in which nothing will be given to them during the course of
           treatment.
    

Detailed description: 
      The assessment of oral-health-related quality of life during the different stages of
      orthodontic treatment is probably unique in the literature.

      The study will cover the different stages of orthodontic treatment from A to Z. In other
      words, patients will be followed up till the end of treatment at which fixed appliances are
      removed. Pain control will be accomplished in one arm using LLLT and in another arm by
      prescribing Panadol Extra®. A third group will be left without any medication or laser
      irradiation to serve as a control group.
    

Intervention name(s): low-level laser therapy; Panadol-extra
Intervention type(s): Radiation; Drug
Intervention description(s): low-level laser therapy will be used to relieve pain and discomfort during orthodontic treatment at specific time points.; Tablets of 565-mg Panadol-extra will be used at specific time points to control pain and discomfort
Intervention MeSH terms: Acetaminophen
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Effect of Robotic Therapy on Upper Extremity With Stroke
Condition: the Effect of Virtual Reality on Stroke Rehabilitation
MeSH terms: Stroke
Study type: Interventional

Summary: 
      The purpose of this study is to determine how adding virtual reality assisted robotic
      treatment to traditional rehabilitation affects stroke patients' pain levels, functional
      status, and daily living activities.After conventional and robotic therapy Each patient was
      evaluated The Barthel Index (BI), the Fugl Meyer Assessment Upper Extremity (FMA-UE), and the
      Visual Analogue Scale (VAS) were used to assess the patients' pain, daily living activities,
      and upper extremity motor function.
    

Detailed description: 
      The purpose of this study is to determine how adding virtual reality assisted robotic
      treatment to traditional rehabilitation affects stroke patients' pain levels, functional
      status, and daily living activities.

      Materials and Methods: The study included 40 stroke patients. Two groups of patients were
      created. Group I also underwent 20 sessions of upper extremity robot-assisted therapy for 4
      weeks, 5 days a week, for 30 minutes per session, in addition to receiving conventional
      therapy (5 days a week for 4 weeks, 1 hour each day). Group II only got traditional therapy.
      Each patient was assessed both before and after the procedure.

      The Barthel Index (BI), the Fugl Meyer Assessment Upper Extremity (FMA-UE), and the Visual
      Analogue Scale (VAS) were used to assess the patients' pain, daily living activities, and
      upper extremity motor function.
    

Intervention name(s): robotic exercise therapy; conventional therapy
Intervention type(s): Other; Other
Intervention description(s): Functional exercise programs such as collecting rain in a glass, grating vegetables, goalkeeper, cleaning the stove, watering flowers, wiping windows, catching fish, and exploring landscapes were applied by robotic games to the patients; streching, range of motion, strengthening, balance and walking exercise
Other intervention name(s): robotic exercise
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: stroke; upper extremity; robot-assisted therapy; armeo