Curcumin-Simvastatin-EDTA in the Treatment of Periodontitis
Condition: Periodontitis
MeSH terms: Periodontitis
Study type: Interventional
Phase: Phase 4

Summary: 
      Among the root conditioning materials is the Ethylenediaminetetraacetic acid (EDTA). EDTA
      exposes the collagen fibers on dentin surfaces and also enhances early cell colonization.
      Statins have an anti-inflammatory effect, inhibit the bone resorption and stimulate the bone
      formation. Curcumin is effective in preventing periodontal disease destruction by targeting
      both bacteria and host inflammatory cells. Curcumin has anti- inflammatory, antioxidant,
      anticarcinogenic, antiviral, and antimicrobial functions. This study will be carried out to
      examine the effect of simvastatin-curcumin paste following EDTA root surface etching when
      used in conjunction with open flap debridement treating deep periodontal pockets (suggesting
      that it may have positive effect)
    

Detailed description: 
      The present study entailed thirty patients having stage II or stage III, Grade A
      periodontitis with 30 intrabony defects. Patients were divided into three groups; group I was
      subjected to open flap debridement only. Group II was subjected to open flap debridement
      followed by application of curcumin-simvastatin paste (2% curcumin and 1.2% simvastatin).
      Group III was subjected to open flap debridement followed by 24% EDTA root surface etching
      and application of curcumin-simvastatin paste (2% curcumin and 1.2% simvastatin).Clinical
      parameters including plaque index, sulcus bleeding index, probing depth and clinical
      attachment level were recorded pre-surgical. Moreover, radiographic examination was performed
      by cone beam computed tomography (CBCT) just before the surgery . Vertical bone defects were
      exposed by full thickness mucoperiosteal flap following intrasulcular incision and thorough
      debridement was performed. Group II received local application of curcumin-simvastatin paste
      .Group III received curcumin-simvastatin paste after debridement and 24 % EDTA. The same
      initial clinical parameters were recorded three and six months postoperatively. Radiographic
      measurements were recorded six months post surgically.
    

Intervention name(s): currettage; curcumin simvastatin paste; EDTA root conditioning
Intervention type(s): Procedure; Drug; Drug
Intervention description(s): open flap debridement; Curcumin is the primary active constituent of turmeric. Simvastatin is chemical modification of lovastatin.; EDTA is an aminopolycarboxylic acid and a colourless, water-soluble solid
Other intervention name(s): surgical treatment of periodontal defects; open flap debridement followed by application of curcumin-simvastatin paste (2% curcumin and 1.2% simvastatin).; open flap debridement followed by 24% EDTA root surface etching and application of curcumin-simvastatin paste (2% curcumin and 1.2% simvastatin).
Intervention MeSH terms: Curcumin; Simvastatin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: periodontitis; curcumin; simvastatin; EDTA