bioihbjkbjnl/mcl2 huggingface dataset:
Occurrence of Selected Vitamins in Saliva and Blood
Condition: Divorced State
Study type: Observational

Summary: 
      There is an interest to assess nutritional status of vitamins in humans in a non-invasive
      way, i.e. by avoiding taking blood samples. Saliva could potentially be an alternative to
      blood for this purpose. The suitability of saliva for status determination will be
      investigated by analysis of (forms of) vitamins A and E, B1, B2, B3, B6 and C in both saliva
      and blood.
    

Detailed description: 
      There is an interest to assess nutritional status of vitamins in humans in a non-invasive
      way, i.e. by avoiding taking blood samples. Saliva could potentially be an alternative to
      blood for this purpose. However, literature data on vitamins in saliva is scarce. The
      occurrence is best demonstrated for 25-hydroxy-vitamin D3 where already indications for a
      correlation to blood levels have been observed in a small scale supplementation study.
      Occurrence of (forms of) vitamins A and E, B1, B2, B3, B6 and C has been reported but is less
      well documented. Some information is somewhat ambiguous and for none of these latter vitamins
      blood levels have been investigated in parallel to saliva.
    

Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        A total of 50 subjects (females and males, with at least 40% of each gender) generally
        regarded as healthy in the age of 20 - 65 years.
A Brief Cognitive Intervention After Intrusive Memories of Trauma With Young Refugees
Condition: Intrusive Memories of Trauma, Symptom of Post Traumatic Stress Disorder (Criterion B1)
MeSH terms: Wounds and Injuries; Stress Disorders, Traumatic; Stress Disorders, Post-Traumatic
Study type: Interventional

Summary: 
      This research study is designed to investigate the use of a simple cognitive task (a memory
      cue and 10 minute time gap, followed by playing the computer game "Tetris") for decreasing
      the number of intrusive memories of trauma among young refugees and asylum seekers. The
      design is a single case experimental AB design with or without optional replication (ABAB).
      Participants will aim to complete a no-intervention phase ('A': baseline phase) of one week
      followed by a one-week intervention phase ('B'), including a one-session intervention with a
      researcher comprising the simple cognitive task, followed by instructions to continue to use
      the technique self-guided in the subsequent week. Follow ups are conducted after each week to
      monitor the occurrence of intrusive memories of trauma in a pen-and-paper diary. It is
      predicted that participants will report fewer intrusive memories during the intervention
      phase than during the preceding baseline phase.
    


Intervention name(s): Brief cognitive intervention
Intervention type(s): Behavioral
Intervention description(s): A one-session intervention with a researcher including a simple cognitive task (a memory cue, 10 minutes time gap and ca. 20 minutes of Tetris game play) with instructions to engage in the task self-guided in the subsequent week.
Intervention model: Single Group Assignment
Intervention model description: Single case experimental AB design with or without optional replication (ABAB) (ie no random assignment)
Masking: None (Open Label)
Primary purpose: Other
The Effect of Acupressure Application on Menopausal Symptoms
Condition: Menopausal Syndrome
Study type: Interventional

Summary: 
      The study was conducted randomly controlled to determine the effect of acupressure
      application on menopausal complaints among women who applied to Cancer Early Diagnosis and
      Screening Center.
    

Detailed description: 
      Research, between September 2019 and February 2020 of cancer in the body healthy life center
      in the east of the provincial center of Turkey was held by early diagnosis and screening
      center that refer to women.

      The Universe and Sample of the Research The universe of the study consisted of women who
      applied to cancer early diagnosis and screening center for examination for any reason.

      The calculation of the sample size of the study was determined according to the studies in
      which non-pharmacological methods were used to cope with menopausal symptoms. The calculation
      was determined according to the effect size of 0.5 in a moderate level, considering the
      effect size ranging between (0.25-0.83) reported by the studies on the subject.
    

Intervention name(s): Acupressure Application
Intervention type(s): Other
Intervention description(s): Acupressure was administered in a semi-sitting or supine position where the woman felt comfortable and the researcher could perform the practice comfortably to the acupressure points. The application was performed on the determined acupressure points by considering the direction of the meridian in a certain order. It was performed with the administration order of Spleen 6th point (SP 6) and Large Intestine 4th point (Li 4). In total, the administration was performed with 4 acupressure points including 2 points in the upper/lower extremity along with the parallel points in each intervention.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Investigator)
Primary purpose: Supportive Care
Healthy Lifestyles for Mentally Ill People Who Have Experienced Weight Gain From Their Antipsychotic Medications - 2
Condition: Diabetes; Obesity; Weight Gain
MeSH terms: Obesity; Weight Gain
Study type: Interventional

Summary: 
      This program aims to help Veterans who take antipsychotic medications lose weight. We use a
      program based on the American Diabetes Association's "Diabetes Prevention Program," and we
      have modified it to fit the lifestyles of people with mental illness. All participants are
      educated about nutrition and cutting down fat intake, how and when to exercise, and the
      causes of diabetes and how to prevent it. Participants must be Veterans who live within one
      hour of the Long Beach, West Los Angeles, Sepulveda, or West Los Angeles VA hospitals.
    


Intervention name(s): Lifestyle Balance
Intervention type(s): Behavioral
Intervention description(s): Patients assigned to the behavioral weight loss program (Lifestyle Balance Program) will do the following: -Meet with their psychiatrist and a nutritionist who will go over diet recommendations with the patient - Be given a 7% weight loss goal - Be assisted in obtaining a 500 calorie reduction per day -Exercise for at least 30 min/day, at least 5 days a week - Maintain weekly food and exercise diaries -Be quizzed on their knowledge of healthy eating habits and nutrition
Other intervention name(s): Lifestyle Balance Program
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Antipsychotic; Bipolar; Diabetes; Mental Illness; Nutrition; Obesity; Schizoaffective; Schizophrenia; Weight Gain; Weight Loss
Effects of Topical Cream for Pain Relief
Condition: Chronic Pain
MeSH terms: Chronic Pain
Study type: Interventional

Summary: 
      To perform a clinical proof-of-concept study on a novel topical formula for pain relief.
    

Detailed description: 
      An open-label study where each participant will be involved in the study for 4 weeks. During
      the study participants will use the topical cream 1-2 times daily on the anatomical area(s)
      causing the most pain.
    

Intervention name(s): Topical cream
Intervention type(s): Other
Intervention description(s): Topical cream applied to painful joint or muscle
Intervention model: Single Group Assignment
Intervention model description: An open-label study design where all study participants will receive the active test product and no placebo is used.
Masking: None (Open Label)
Primary purpose: Basic Science
The Chronic Effects of Beetroot Juice in Hypertensive Subjects
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      We are interested in the effect of diet on blood pressure. Our previous research has shown
      that beetroot juice lowers blood pressure in healthy people. We now want to see if beetroot
      juice has this effect in people with high blood pressure. Beetroot juice is naturally rich in
      nitrate (also found in most other vegetables but particularly in green leafy vegetables). We
      think that it is the nitrate that lowers the blood pressure.
    


Intervention name(s): beetroot juice; Nitrate-free beetroot juice
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Beetroot juice 4 weeks 250ml daily; Nitrate-free beetroot juice 4 weeks 250ml daily
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Keywords: hypertension; nitrite; blood pressure; endothelial function
ACS-NSQIP Calculator for Liver Surgery
Condition: Liver Surgery; Hepatectomy; Outcome After Hepatectomy
Study type: Observational

Summary: 
      The American College of Surgeons National Surgical Quality Improvement Program's (ACS-NSQIP)
      calculator has been endorsed by the surgeons' community to counsel patients and relatives
      regarding estimated postoperative complications. However, it does not include organ-specific
      risks. The aim of this study was to assess the ACS-NSQIP calculator's ability to predict
      complications, mortality and length of stay (LOS) in patients undergoing hepatectomy for
      liver tumors
    

Detailed description: 
      This is an observational retrospective study conducted in a tertiary-referral university
      hospital. An established classification of complications, including post-hepatectomy
      insufficiency and bile leak, was adopted. The endpoint was the rate of complications,
      mortality and LOS as expected by the ACS-NSQIP calculator and as observed within 90-day after
      surgery.
    

Intervention name(s): Liver resection
Intervention type(s): Procedure
Intervention description(s): Surgery for the liver
Other intervention name(s): Hepatectomy
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        The study examined a cohort of consecutive patients that underwent hepatectomy at our
        institution between November 2015 and July 2018.
A Study in the Treatment of Children and Adolescents With Major Depressive Disorder
Condition: Major Depressive Disorder
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to assess whether duloxetine is superior to placebo in the
      treatment of children and adolescents with major depressive disorder (MDD)
    


Intervention name(s): duloxetine; Placebo; fluoxetine
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 30-120 mg, PO, QD, for up to 38 weeks; Capsules identical in appearance, color, taste and smell to study drug, orally (PO), once daily (QD). Dose: placebo, 6 capsules, QD for 10 weeks; 10-40 milligram (mg), PO, QD, for up to 38 weeks
Other intervention name(s): LY248686; Cymbalta; LY110140; Prozac
Intervention MeSH terms: Duloxetine Hydrochloride; Fluoxetine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Study Investigating the Effects of Niagen™ in Healthy Adults.
Condition: Bioavailability
Study type: Interventional
Phase: Phase 2

Summary: 
      This study will evaluate the effect of repeated doses of Niagen™ on Niagen™ metabolite
      concentrations in blood, urine and muscle. There will be 3 doses of Niagen™ compared to a
      placebo. One quarter of subjects will receive the low dose of Niagen™, one quarter will
      receive the moderate dose of Niagen™, one quarter will receive the higher dose of Niagen™ and
      one quarter will reveive the placebo.
    


Intervention name(s): Niagen™ 100; Niagen™ 300; Niagen™ 1000; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
Keywords: Healthy participants; Dietary supplement; Bioavailability; Niagen™; Nicotinamide riboside; N-methylnicotinamide
AGN-151586 Dose-Ranging Study for Treatment of Glabellar Lines
Condition: Glabellar Lines
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate the safety and efficacy of AGN-151586 over a range
      of doses for the treatment of moderate to severe glabellar lines (GL).
    


Intervention name(s): AGN-151586; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): AGN-151586 solution for injection.; Placebo solution for injection.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
AMPLATZER Duct Occluder II Clinical Study
Condition: Patent Ductus Arteriosus
MeSH terms: Ductus Arteriosus, Patent
Study type: Interventional

Summary: 
      The objective of this study is to investigate the safety and effectiveness of the ADO II in
      patients with a PDA.
    


Intervention name(s): AMPLATZER Duct Occluder II
Intervention type(s): Device
Intervention description(s): AMPLATZER Duct Occluder II
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: patent ductus arteriosus; PDA
Dose Ranging Study of SPL7013 Gel for Treatment of Bacterial Vaginosis (BV)
Condition: Bacterial Vaginosis
MeSH terms: Vaginosis, Bacterial; Vaginal Diseases
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine the efficacy of SPL7013 Gel in the treatment of
      bacterial vaginosis.
    


Intervention name(s): 0.5% SPL7013 Gel; 1.0% SPL7013 Gel; 3.0% SPL7013 Gel; Placebo Gel
Intervention type(s): Drug; Drug; Drug; Other
Intervention description(s): Vaginal gel; Vaginal gel; Vaginal gel; Vaginal gel
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: SPL7013; VivaGel; bacterial vaginosis; BV
Effects of Dexmedetomidine on Oxygenation and Lung Mechanics in Morbidly Obese Patients Undergoing Bariatric Operations
Condition: Restrictive Lung Disease
MeSH terms: Lung Diseases
Study type: Interventional
Phase: Phase 4

Summary: 
      The study aims to investigate the effect of dexmedetomidine on oxygenation and lung mechanics
      in morbidly obese patients
    

Detailed description: 
      The patients of interest are morbid obese patients scheduled for bariatric surgery.
      Dexmeditomidine will be infused intraoperatively after induction of anesthesia. lung
      mechanics (dead space and compliance) as well as oxygenation (PF ratio) will be monitored
      intraoperatively and postoperatively
    

Intervention name(s): Dexmedetomidine; Normal saline
Intervention type(s): Drug; Drug
Intervention description(s): Dexmedetomidine infusion was previously reported to improve oxygenation and lung dynamics in patients with obstructive lung diseases. In our study we are going to investigate its effect on oxygenation and lung dynamics in restrictive lung disease; Normal saline
Other intervention name(s): Precedex; Saline
Intervention MeSH terms: Dexmedetomidine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Study Of Palbociclib (PD-0332991) In Renal Impairment
Condition: Renal Impairment
MeSH terms: Renal Insufficiency
Study type: Interventional
Phase: Phase 1

Summary: 
      Since the amount of palbociclib eliminated in urine is 6.9%, renal impairment is not expected
      to have much impact on palbociclib. However, the Federal Drug Administration (FDA) Guidance
      recommends a study in subjects with renal impairment when the drug is likely to be used in
      patients with impaired renal function. Palbociclib is intended for chronic use in cancer
      patients who may have some degree of impaired renal function.
    


Intervention name(s): palbociclib; palbociclib; palbociclib; palbociclib
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): palbociclib 125 mg oral capsule with food once; palbociclib 125 mg oral capsule with food once; palbociclib 125 mg oral capsule with food once; palbociclib 125 mg oral capsule with food once
Intervention MeSH terms: Palbociclib
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: renal impairment; AUC; Cmax; palbociclib; normal matched subjects
A Single-dose, Open-label, Parallel-group Study to Assess the Pharmacokinetics of BAF312 in Subjects With Renal Impairment Compared to Subjects With Normal Renal Function
Condition: Renal Impairment
MeSH terms: Renal Insufficiency
Study type: Interventional
Phase: Phase 1

Summary: 
      to quantify the effect of different degrees of renal impairment on the pharmacokinetics of
      BAF312 (and selected metabolites) and to assess safety and tolerability in order to develop
      dosing recommendations for subjects with renal impairment
    


Intervention name(s): BAF312
Intervention type(s): Drug
Intervention description(s): Treatment with a single oral dose of 0.25 mg BAF312
Intervention MeSH terms: Siponimod
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: renal impairement; pharmacokinetics
Patient Safety in the Operating Room: Helsinki Declaration Implementation in Ukraine
Condition: Safety Issues
Study type: Observational

Summary: 
      Athe study to evaluate the implementation of the components of the Declaration of Helsinki in
      Ukrainian hospitals, as well as other safety measures during surgeries.
    

Detailed description: 
      A study was conducted from May 2021 to September 2021 at the Ukrainian hospitals. The study
      design was approved by the Ethical Committee at Bogomolets National Medical University. The
      survey was conducted by filling out a standard Google form. The link to the survey was
      distributed on the official page of the Association of Anesthesiologists of Ukraine, through
      social networks Facebook and Instagram on the official webpages of the Department of Surgery,
      Anesthesiology and Intensive Care of the Institute of Postgraduate Education of NMU. O.O.
      Worshipers. A total of 174 respondents took part in the survey.

      To conduct the survey, we formed a questionnaire of 24 items. The questionnaire was designed
      to ensure sufficient collection of data from respondents on demographics, awareness of the
      Declaration, and the use in the everyday practice of the measures recommended in it to
      promote patient safety. However, the structure of the questionnaire allowed people to fill it
      in a short time. We also provided respondents with more descriptive and detailed answers to
      some questions if they wished. The survey was conducted in Ukrainian.
      Practitioners-anesthesiologists, as well as heads of departments, employees of departments,
      were invited to participate in the survey.

      The survey results were imported into a Microsoft Excel spreadsheet for further analysis.
      Simple descriptive statistics were used for demographic data and numerical answers to
      individual questions. The answers, which included the free text were grouped by topic using
      simple qualitative techniques.
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Experienced anesthesiologists from most regions of Ukraine were interviewed.
      
Keywords: patient safety; monitoring; Helsinki Declaration
Feasibility - Infinitome
Condition: Alzheimer Disease
MeSH terms: Alzheimer Disease
Study type: Observational

Summary: 
      The Infinitome Program from Omniscient has the ability to identify abnormal brain networks or
      connectomes using resting state functional MRI (rs-fMRI). This technology, which visualizes
      brain networks in three dimensions, was originally developed to ensure neurosurgeons avoid
      inadvertently lesioning cognitively eloquent brain regions during surgical operations. The
      potential of Infinitome in identifying connectome dysfunction for neurodegenerative diseases
      such as Alzheimer's disease has yet to be explored. This diagnostic technique may play a
      critical role for identifying disease brain networks that may benefit from targeted
      interventions in clinical trials.
    


Intervention name(s): Infinitome
Intervention type(s): Procedure
Intervention description(s): Added sequence of rs-fMRI.
Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        HealthPartners Neurology Clinic in Saint Paul, MN undergoing care for Alzheimer's disease.