Combination Plant-Based Protein and Marine-Based Multi-Mineral Supplement and Bone Remodeling in Young Adults
Condition: Bone Resorption; Bone and Bones
MeSH terms: Bone Resorption
Study type: Interventional

Summary: 
      Nutrient intake of calcium and protein are known to function as regulators of bone
      remodeling. Specifically, a balanced rate of bone resorption and bone formation (i.e. bone
      remodeling process) is required to maintain bone health. However, a high remodeling rate, or
      an imbalance between formation and resorption, as well as suboptimal nutrient intake are
      known to contribute to fracture risk and bone dysfunction.

      Gut-derived hormones represent an important link between nutrient intake and bone remodeling
      (i.e. gut-bone axis). A sustainable nutritional intervention that positively modulates the
      postprandial responses of gut-derived hormones and the linked bone remodeling processes is an
      attractive option for the optimization of bone health in young adults.

      The proposed nutrient intervention seeks to explore the bioefficacy of a combination
      plant-based protein and marine-based multi-mineral supplement following oral ingestion in
      young, healthy men and women. A postprandial time-course study will be undertaken to examine
      the acute effects and/or associations between different gut-derived hormones and biomarkers
      of bone metabolism.
    

Detailed description: 
      A block-randomized, within-subject, two-day, crossover design examining acute (0-4 hour)
      postprandial changes in different gut-derived hormone concentrations and biomarkers of bone
      metabolism in 12 healthy, young adults following ingestion of a combination plant-based
      protein and marine-based multi-mineral supplement or control.

      Each participant will consume (in a random manner) either one of two investigational products
      (i.e., combined nutritional supplement or control). The combined nutritional supplement will
      consist of: 0.3 g/kg body mass of ATURA Fava-Bean Protein and 800mg of Aquamin F (a highly
      bioactive source of minerals rich in calcium) dissolved in 500ml water volume. The control
      product will consist of 500ml water volume without the protein and multi-mineral nutritional
      composition.
    

Intervention name(s): Combined Plant-Based Protein and Marine-Based Multi-Mineral Supplement; Placebo Control
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Ingestion of the Test Product at 07.00am - Fava-bean protein concentrate dosed at 0.33 g/kg body mass and Aquamin F dosed at 800mg in 500 ml water volume. Supplied by Marigot Limited, Strand Farm Currabinny, Co. Cork, Ireland; Ingestion of the Control Product at 07.00am - 500ml water volume.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: A block-randomized, within-subject, two-day, crossover design examining acute (0-4 h) postprandial changes in different gut hormone concentrations and bone remodeling biomarkers in 12 healthy, young adults following ingestion of a combination plant-based protein and marine-based multi-mineral supplement or control.
Masking: Single (Investigator)
Primary purpose: Other
Keywords: nutrition; plant; marine; protein; bone; skeletal; health; dietary supplements; sustainable