Scalp Acupuncture Combined rTMS on Brain White Matter Microstructure of Hemiplegic Patients With Stroke
Condition: Stroke
MeSH terms: Stroke
Study type: Interventional

Summary: 
      To apply Bold-fMRI technology to observe and compare the differences of task-related
      activation of relevant brain cortex region in stroke hemiplegic patients and healthy subjects
      after finger grasping movement.
    

Detailed description: 
      Stroke is one of the common cerebrovascular diseases. With the improvement of medical
      conditions and treatment technology, the death rate of stroke patients has declined, but the
      disability rate has increased. In China about 50%-70% of stroke patients have the residual
      sequelae such as paralysis, paralalia dysfunction and so on.

      Hemiplegic is the most frequent sequelae in post-stroke patients, finger movements recovery
      has already became the most difficult question in all the movement kinematics and dynamics
      rehabilitation,which affects the total movement function and ability of daily life in the
      patients.The finger recovery is tightly related to the neural plastic and brain function
      realignment.Furthermore, whether the special brain movement functional cortex area in
      bilateral hemispheres can be effectively activated is the crucial solved link. A number of
      recent literature have displayed the special brain motor area including the primary motor
      cortex(M1), the supplementary motor area(SMA), the premotor area(PMA), the primary
      sensorimotor area(SM1),the secondary area(SM2), the cingulate sulcus area(CMA) and the
      cerebellum hemispheres(CB). However，the study on the above-mentioned motor area synchronously
      activated when the patients after systematically rehabilitative treatment performed fingers
      grasping task was reported rarely.

      Bold-fMRI technology is a new brain functional imaging technology developed on the basis of
      MRI in 1990s, which not only retains the anatomical imaging characteristics of ordinary MRI,
      but also obtains the physiological information. The emergence of Bold-fMRI technology
      provides a new way to study the mechanism, evaluation and prognosis of stroke rehabilitation,
      and it shows a good research and clinical application value in the field of rehabilitation
      medicine.
    

Intervention name(s): the experimental group; the control group
Intervention type(s): Other; Other
Intervention description(s): Stroke hemiplegia patients are randomly assigned to the experimental group (scalp acupuncture + low frequency repetitive transcranial magnetic stimulation + routine rehabilitation treatment). All patients in the day of inpatient and the fourteenth day received DTI magnetic resonance examination twice to study the change in white matter fiber microstructure.; Stroke hemiplegia patients are randomly assigned to the control group (scalp acupuncture + routine rehabilitation treatment). All patients in the day of inpatient and the fourteenth day received DTI magnetic resonance examination twice to study the change in white matter fiber microstructure.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: All the hemiplegic patients were mainly derived from stroke recovery periodical inpatients from September 2015 to September 2016 in rehabilitation unit of shenzhen nanshan district people's hospital, Guangdong Province,China. All subjects were told in detail about the risks and signed informed consent before the experiment.
Masking: None (Open Label)
Primary purpose: Treatment