Hypertension, Antihypertensive Medication Use, and Risk of Psoriasis
Condition: Psoriasis
MeSH terms: Hypertension; Psoriasis
Study type: Observational

Summary: 
      The influences of hypertension and antihypertensive medication on psoriasis have been long
      discussed. Given the limited and inconsistent evidence available, there is a need to further
      explore and clarify the relationship between hypertension and psoriasis, as well as to assess
      the relationship between antihypertensive medication use and the development or worsening of
      psoriasis symptoms. The aim of this retrospective study was to analyze data from electronic
      health records in a large population-based cohort, and the investigators aimed to investigate
      whether there was a significant association between hypertension and the use of related
      antihypertensive medications, such as ACEis, and psoriasis, and to explore potential
      confounders that may influence this association. Understanding the potential relationship
      between antihypertensive medication and psoriasis is critical, as this may have implications
      for the management of hypertension in patients with psoriasis or those at risk of developing
      the condition. This study will contribute to the existing body of evidence and provide
      valuable insights for clinicians to make informed decisions about the use of antihypertensive
      medication in this patient population, ultimately contributing to more effective prevention
      and management strategies for individuals affected by these diseases.
    

Detailed description: 
      The investigators conducted a retrospective cohort study of psoriasis patients (≥18 years
      old) admitted as inpatients of Xijing hospital. Prior to the commencement of the survey, the
      investigators underwent collective training on data collection procedures to ensure the
      quality and reliability of the data. The study population included psoriasis patients aged 18
      years or older who had been hospitalized at least once between 2012 and December 2022.
      Healthy individuals being randomly selected healthy individuals from a medical examination
      center. According to local ethics, the investigators have applied for exemption from written
      informed consent.

      Patients with psoriasis in the Department of Dermatology, Xijing Hospital of Air Force
      Medical University from December 2012 to December 2022 were consecutively collected.
      Inclusion criteria: (1) age ≥18 years; (2) Clear diagnosis of psoriasis. Exclusion criteria:
      (1) age <18; (2) Hypertension caused by conditions such as primary hypertension,
      hyperthyroidism, chronic renal insufficiency, or Cushing's syndrome, which are severe
      endocrine system diseases; (3) Patients with autoimmune diseases, severe cardiovascular,
      hepatic, renal, or other major organ disorders, as well as blood disorders and endocrine
      system diseases.

      The study collected various parameters, including baseline information such as ID number,
      gender, date of birth, medical history, and family history. Psoriasis-related data included
      age at first onset, date of diagnosis, duration of disease, frequency of relapse, psoriasis
      subtype, history of systemic/local medication, and comorbidities such as hypertension and
      dyslipidemia.

      Furthermore, clinical examination data and laboratory tests were conducted, which included
      measurements such as height, weight, systolic blood pressure (SBP), diastolic blood pressure
      (DBP), PASI score (Psoriasis Area and Severity Index), fasting plasma glucose (FPG), total
      cholesterol (TC), total triglycerides, uric acid, neutrophil count (normal range 1.80-6.30 ×
      109/L), and lymphocyte count (normal range 1.00-4.80 × 109/L). It is important to note that
      all blood tests were conducted prior to any treatment.

      The above information was obtained from the Medical Record System of Xijing Hospital of Air
      Force Medical University.
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        The investigators conducted a retrospective cohort study of psoriasis patients (≥18 years
        old) admitted as inpatients of Xijing hospital. Prior to the commencement of the survey,
        the investigators underwent collective training on data collection procedures to ensure the
        quality and reliability of the data. The study population included psoriasis patients aged
        18 years or older who had been hospitalized at least once between 2012 and December 2022.
        Healthy individuals being randomly selected healthy individuals from a medical examination
        center.
      
Keywords: Hypertension; Antihypertensive Medication; Psoriasis