bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Motor Cognitive Training on Functional Loss After Osteoporotic Wrist Fractures
Condition: Osteoporotic Distal Radius Fracture
MeSH terms: Fractures, Bone; Radius Fractures; Wrist Fractures
Study type: Interventional

Summary: 
      The therapy results after distal radius fracture especially of elderly patients are often
      suboptimal. The central problem results from the inevitable, 3-6-weeks immobilization, which
      leads to reduction in ROM of the wrist, deterioration of muscle strength as well as
      malfunction of fine motor skills and coordination. Currently, there are no adequate proactive
      strategies to counteract these immobilisation problems. Hence the overall aim of our research
      project is to investigate the therapeutic potential of a motor-cognitive therapy on hand
      function after distal radius fracture. On the one hand the pilot study should provide
      information about the level of recruitment rate necessitated for an adequate sample size
      which allows reliable evidence for the therapy effects. On the other hand we want to evaluate
      the sensitivity and adequacy of the assessment instruments.

      The pilot is conceived as a controlled, randomised, longitudinal intervention study over 6
      weeks with 3 groups. One experimental group imagine movements and actions without executing
      them. A second experimental group performs mirror training, in which visual feedback through
      a mirror activates additionally the contralateral hemisphere. The control group receives
      therapy as usual. There are three key domains to be analysed: function (PRWE), impairment
      (ROM, strength) and participation in social life/life quality (DASH, EQ5D).
    


Intervention name(s): motor cognitive therapies
Intervention type(s): Behavioral
Intervention description(s): pre-test; 6 weeks intervention: week 1-3: 5 times per week 60 minutes a day. Week 4-6: 3 times per week 60 minutes a day; post-test; follow-up)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: osteoporosis; wrist fracture; mental practice; mirror therapy; immobilization; elderly
Effect of Type-A Botulinum Toxin in the Post-radiosurgical Neck Contractures
Condition: Cervical Spasm; Radiotherapy Side Effect; Botulinum Toxin
MeSH terms: Contracture; Torticollis
Study type: Interventional
Phase: Phase 2

Summary: 
      The main objective of the study is to estimate the efficiency and to determine the optimal
      dose of Botulinum toxin A, administered by intramuscular way in cervical spasms after
      radiotherapy, as well as the optimal sites for these injections.

      The concerned muscular groups are the sternocleidomastoid (SCM), the trapezius muscle and the
      splenius capitis.
    


Intervention name(s): Botulinum toxin A; Placebo
Intervention type(s): Drug; Procedure
Intervention description(s): Injection of sodium chloride (NaCl) 9/1000
Intervention MeSH terms: Botulinum Toxins; Botulinum Toxins, Type A; abobotulinumtoxinA
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Study of Low Level Laser Therapy for Body Contouring
Condition: Body Contouring
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether green diode low level laser therapy is
      effective for body contouring of the waist, hips and thighs.
    

Detailed description: 
      Weight loss and body contouring are large, constantly-growing fields of cosmetic surgery.
      According to the American Society of Plastic Surgeons (ASPS) statistics, more than 324,000
      liposuction procedures, 233,000 eyelid surgeries and 114,000 facelift procedures were
      performed in 2004 in the United States alone. However, while the demand for body shaping
      procedures is constantly on the rise, so is the demand for such procedures to be performed
      more quickly, simply and most importantly, less invasively. Cosmetic surgery patients are no
      longer satisfied with procedures that require general anesthesia, pose a multitude of
      potentially serious risks and complications and that require several weeks of recovery time.
      Hence the growing popularity of non- to minimally-invasive cosmetic surgery procedures. In
      2005, more than 7.5 million minimally-invasive cosmetic procedures were performed, a 35%
      increase from 2000. Consequently, patients and physicians alike are continually searching for
      non-invasive alternatives to traditional cosmetic procedures such as liposuction that are
      efficient, safe and effective.
    

Intervention name(s): Erchonia ML Scanner (MLS); Sham device
Intervention type(s): Device; Device
Intervention description(s): Red diode low level laser light energy.; non-therapeutic light energy output
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: non-invasive body contouring of waists hips and thighs
Correlation of Audiovisual Features With Clinical Variables and Neurocognitive Functions in Bipolar Disorder, Mania
Condition: Bipolar Disorder, Manic; Artificial Intelligence; Neurocognition; Treatment Resistant Disorders; Affective Computing; Multi- Modal Analysis
MeSH terms: Bipolar Disorder
Study type: Observational

Summary: 
      The aim of this study is to show the physiological changes during manic episode in bipolar
      mania how much they differentiate from remission and healthy control. Relation of
      audio-visual features as physiological changes and cognitive functions and clinical variables
      will be searched. The aim is to find biologic markers for predictors of treatment response
      via machine learning techniques to be able to reduce treatment resistance and give an idea
      for personalized treatment of bipolar patients.
    

Detailed description: 
      The objective of this research protocol is to find audio-visual features which differentiates
      bipolar mani/ remission/ health/ simulation and predicts treatment response earlier and
      detect neurocognitive changes during mania/ remission and difference from the healthy
      control. During hospitalization in every follow up day (0th- 3rd- 7th- 14th- 28th day) and
      after discharge on the 3rd month, presence of depressive and manic features for patients was
      evaluated using Young Mania Rating Scale(YMRS) and Montgamery- Asberg Depresyon Scale
      (MADRS). Audiovisual recording is done by a video camera in every follow up day for patients
      and for healthy controls which includes also depression and mania simulation. Cambridge
      Neurophysiological Assessment Battery (CANTAB) were administered to both groups( for patients
      both in the manic phase and in the remission) to assess neurocognitive functions.
    

Intervention name(s): Ongoing treatment for bipolar mania; Audiovisual recording during guided presentation
Intervention type(s): Drug; Diagnostic Test
Intervention description(s): Prescribed by the following doctor during hospitalization and after discharge; Seven tasks such as explaining the reason to come to hospital/participate in the activity, describing happy and sad memories, counting up to thirty, explaining two emotion eliciting pictures
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Bipolar mania patients from the inpatient service Healthy controls from the community
        around hospital
      
Keywords: Bipolar and Related Disorders; Mood Disorders; Mental Disorders; Behavioral Symptoms; Cognitive functions; Simulation
Evaluating the Safety, Tolerability, and Efficacy of GS-9674 in Participants With Nonalcoholic Steatohepatitis (NASH)
Condition: Nonalcoholic Steatohepatitis (NASH)
MeSH terms: Fatty Liver; Non-alcoholic Fatty Liver Disease
Study type: Interventional
Phase: Phase 2

Summary: 
      The primary objective of this study is to evaluate the safety and tolerability of GS-9674 in
      participants with nonalcoholic steatohepatitis (NASH).
    


Intervention name(s): GS-9674; Placebo to match GS-9674
Intervention type(s): Drug; Drug
Intervention description(s): Tablet administered orally once daily; Tablet(s) administered orally once daily
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Non-alcoholic fatty liver disease (NAFLD); Fibrosis; GS-9674
The Optimal Time to Put Laryngeal Mask Airway in the Mouth Under General Anesthesia
Condition: General Anesthesia
Study type: Interventional

Summary: 
      Laryngeal mask airway (LMA) is routinely used for some patients who have surgery under
      general anesthesia. LMA is placed in the mouth and allow the anesthesia to be given without
      having to put a breathing tube in the throat. Previous studies have focused on the effect of
      different anesthesia medicines on optimal condition for LMA use. The objective of the present
      study is to find the optimal time for LMA insertion.
    

Detailed description: 
      This is a randomized, controlled, blinded trial. Midazolam, 2 mg and fentanyl 1.0 µg/kg,
      would be given prior to induction with propofol, 2.5 mg/kg.

      The investigator who does the induction of general anesthesia will also be responsible for
      the timekeeping. For this reason, it is not possible for this investigator to be blinded to
      randomization. The induction would conclude after loss of eyelash reflex (LER). At that point
      insertion of the LMA (#4 for females, #5 for males) will occur 0, 60 and 90 seconds after
      LER. The LMA will be lubricated with a water soluble gel and will be inserted with a deflated
      cuff according to the technique described by Brain.

      The investigator who inserts the LMA (Inv1) will be in the operating room and blinded to
      randomization groups by not seeing the induction of general anesthesia. This investigator
      will insert the LMA only when called by the investigator who induces general anesthesia
      (Inv2). Inv1 will also grade ease of LMA insertion.

      The primary outcome is Jaw opening at the time of LMA insertion, defined as full 1, partial
      2, and nil 3.

      Secondary outcomes include:

        1. Insertion of LMA (easy, difficult, impossible)

        2. Coughing or gagging (none, some, significant)

        3. Head or body movement (none, some, significant)

        4. Laryngospasm or airway obstruction (none, partial, total)
    

Intervention name(s): Insertion of Laryngeal Mask Airway
Intervention type(s): Procedure
Intervention description(s): The LMA will be inserted at 0 sec, 60 sec. and 90 sec. after induction of general anesthesia
Other intervention name(s): Laryngeal Mask Airway
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Combined Effects of Manual Therapy on the Shoulder
Condition: Range of Motion; Manual Therapies; Shoulder Joint Disorder
MeSH terms: Joint Diseases
Study type: Interventional

Summary: 
      Interventions including glenohumeral mobilization, sleeper stretches, and thoracic
      manipulation have been proposed for individuals with loss of shoulder range of motion (ROM).
      However, the effect of these interventions on shoulder ROM, joint translation, and muscular
      activity have not been studied in combination.
    

Detailed description: 
      Forty individuals with a loss of internal rotation (IR) ROM will be recruited and randomized
      to one of two interventions at the first session: either posterior glenohumeral mobilization
      or internal rotation "sleeper" stretching. At the second visit, all participants will undergo
      a thoracic manipulation (T3-4 segment) followed by a repeat of either the sleeper stretch or
      glenohumeral mobilization.
    

Intervention name(s): posterior glide mobilization; Sleeper stretch; thoracic manipulation
Intervention type(s): Other; Other; Other
Intervention description(s): The participant will be positioned supine on a plinth, with their scapula stabilized against a firm wedge on the table, and the shoulder joint in the resting position (approx. 55 degrees abduction, 30 degrees horizontal adduction, and slight external rotation). With the extremity held in the same position, the researcher will then apply a grade III (into tissue stretch) PG mobilization. This will consist of five 30-second bouts of sustained gr III posterior glide mobilizations.; All participants randomized to the stretching group will perform five 30-second holds of the sleeper stretch. This is performed by lying on the side to be stretched, elevating the upper arm to 90° on the support surface with the elbow bent 90°, then passively internally rotating the shoulder with force provided by with the opposite arm.; Individuals will then undergo a single supine grade V thrust manipulation. All manipulations will take place at the T3-4 segment. If a cavitation ("pop") is not heard or felt by either the subject or examiner, a second thrust will be performed.
Allocation: Randomized
Intervention model: Sequential Assignment
Intervention model description: All participants will undergo a single intervention during the first session, and then combined thoracic manipulation and a repeat of the prior intervention at the second session.
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: shoulder; Glenohumeral Internal Rotation Deficit (GIRD); joint play; muscular activity
Prevention of Postoperative Ventral Hernias
Condition: Gangrenous Postoperative Ventral Hernia (Diagnosis); Dehiscence of Laparotomy Wound
MeSH terms: Hernia; Hernia, Ventral
Study type: Observational

Summary: 
      The research is aimed at identifying factors of herniation after median laparotomy and
      developing surgical methods for preventing postoperative ventral hernias and eventrations.
    

Detailed description: 
      At the first stage, an analysis of the prevalence of postoperative ventral hernias in
      patients after median laparotomies in urgent surgery will be performed, with the
      identification of factors contributing to the development of postoperative ventral hernias.
      At the next stage, the investigators will search for the most reliable methods of suturing
      the white line of the abdomen, taking into account the risk of hernia formation, with their
      implementation in patients operated in an emergency through median laparotomic access in
      comparison with traditionally used methods. In conclusion, an algorithm will be developed for
      selecting the method of surgical prevention of postoperative ventral hernias, taking into
      account the risk of their development.
    

Intervention name(s): Suturing of a laparotomic wound with modified methods
Intervention type(s): Procedure
Intervention description(s): Suturing the white line of the abdomen with the help of developed techniques aimed at preventing hernias and eventrations
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The prospective study included 700 patients, including those operated through a midline
        laparotomic approach to identify factors of herniation, and those who are planned to have a
        midline laparotomy in order to choose a rational method of suturing a laparotomic wound,
        taking into account the risk of incisional hernia formation. Taking into account the degree
        of risk of postoperative ventral hernia development and the choice of the method of its
        prevention, the patients were divided into 4 groups.
      
Keywords: Postoperative ventral hernia; eventrat; defects of the fascia; laparotomic wound suture; preventive prosthetics of a laparotomic wound
Consistencies in Responses to Sodium Bicarbonate?
Condition: Sports Nutritional Physiological Phenomena
Study type: Interventional

Summary: 
      Intervention studies do not account for high within-individual variation potentially
      compromising the magnitude of an effect. Repeat administration of a treatment allows
      quantification of individual responses and determination of the consistency of responses. The
      investigators aim to determine the consistency of metabolic and exercise responses following
      repeated administration of sodium bicarbonate (SB). Design and Methods: 15 physically active
      males will complete six cycling capacity tests at 110% of maximum power output (CCT110%)
      following ingestion of either 0.3 g∙kg-1Body Mass of SB (4 trials) or placebo (PL, 2 trials).
      Blood pH, bicarbonate, base excess and lactate will be determined at baseline, pre-exercise,
      post-exercise and 5-min post-exercise. Total work done (TWD) will be recorded as the exercise
      outcome.
    


Intervention name(s): sodium bicarbonate; calcium carbonate
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention MeSH terms: Calcium Carbonate; Calcium
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Keywords: Physiological Phenomena
Treatment Trial of Thermoregulatory Disturbances in Adolescent Anorexia Nervosa Patients With Either Ginger Powder Footbaths or Warm Water Footbaths
Condition: Adolescent Anorexia Nervosa
MeSH terms: Anorexia; Anorexia Nervosa
Study type: Interventional

Summary: 
      A study to explore whether warm water footbaths with added ginger powder can improve
      thermoregulatory processes in adolescent anorexia nervosa patients and provide them with an
      increase in subjective feeling of warmth. The participants will receive a warm footbath four
      times a week for six weeks with a physiological and psychological testing point once before
      the beginning of the six-week footbath period and once after.
    

Detailed description: 
      This is a two-arm randomized controlled trial to evaluate the efficacy of warm water
      footbaths with added ginger powder (experimental) compared to warm water only footbaths
      (control) in adolescent anorexia nervosa patients. Participants will receive footbaths 4
      times per week before bed-time over a period of six weeks.The main focus is on subjective
      increase in overall body warmth. Moreover, core body temperature, skin temperature at the
      extremities and several psychological as well as physiological scores and parameters are
      assessed before and after the six-week intervention. A follow-up is planned at six months
      post intervention, where core body temperature, physiological and psychological parameters
      are once more tested.
    

Intervention name(s): ginger powder footbath; warm water only footbath
Intervention type(s): Other; Other
Intervention description(s): 38-40° C warm water footbath with an additive of dried ginger powder reaching up to mid-calf level, as practiced in anthroposophic medicine; 38-40° C warm water footbath without any additive reaching up to mid-calf level
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants are age and core body temperature stratified and then randomized to one of the two groups (footbath with warm water with additional ginger powder or warm water only). Assessments are taken before and after the six-week intervention phase as well as at six-month follow-up.
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Anorexia; Footbath; Ginger powder; Thermogenic substances; Thermoregulation; External applications; Anthroposophic medicine; Eating disorders
Study of Japanese Encephalitis Chimeric Virus Vaccine Given With Measles-Mumps-Rubella Vaccine in Taiwanese Toddlers
Condition: Japanese Encephalitis; Measles; Mumps; Rubella
MeSH terms: Measles; Rubella; Mumps; Encephalitis, Japanese; Encephalitis
Study type: Interventional
Phase: Phase 3

Summary: 
      This study is designed to compare the immunogenicity of Japanese encephalitis chimeric virus
      vaccine (JE-CV) and measles-mumps-rubella (MMR)vaccine when given together or when given at
      separate visits 6 weeks apart in toddlers aged 12 to 18 months.

      Primary objective:

        -  To demonstrate the non-inferiority of the antibody responses in terms of seroconversion
           of the concomitant administration of JE-CV and MMR compared to the antibody responses
           after the single administration of JE-CV and MMR vaccine.

      Secondary objectives:

        -  To describe the immune response to JE CV and MMR before and after one dose of JE CV and
           MMR vaccine, respectively.

        -  To describe the safety of a single dose of JE-CV and MMR vaccine (given separately at a
           6-week interval and the safety of the concomitant administration of JE-CV and MMR
           vaccine in all subjects up to 6 months after last vaccination.
    

Detailed description: 
      All participants will receive Japanese encephalitis chimeric virus vaccine and
      measles-mumps-rubella vaccine and will be monitored for safety throughout the study.
    

Intervention name(s): Japanese encephalitis chimeric virus: Measles, mumps, and rubella live attenuated virus; Japanese encephalitis chimeric virus: Measles, mumps, and rubella live attenuated virus; Japanese encephalitis chimeric virus: Measles, mumps, and rubella live attenuated virus
Intervention type(s): Biological; Biological; Biological
Intervention description(s): 0.5 mL each; Subcutaneous (SC); 0.5 mL each, Subcutaneous (SC); 0.5 mL each, subcutaneous (SC)
Other intervention name(s): JE-CV; MMR II®; JE-CV; MMR II®; JE-CV; MMR II®
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Japanese Encephalitis; Japanese encephalitis chimeric virus vaccine; Measles; Mumps; Rubella