Surgical Treatment With Concentrated Growth Factor for Multiple Papillary Losses
Condition: Papilla, Dentinal; Calcification
MeSH terms: Calcinosis
Study type: Interventional

Summary: 
      The aim of this study was to evaluate the efficacy of concentrated growth factor (CGF) in
      applied in the regenerative treatment of multiple adjacent papillary black triangles (MAPBT)
      occured as a result of soft tissue loss. Interdental papillary regeneration was evaluated
      with the change in the area of interproximal spaces calculated on each of the intraorally
      scanned images obtained with digital impressions of the interproximal space with irregular
      borders.This controlled, examiner-blinded, clinical study included of 40 patients with 120
      open embrasures which resulted from papillary loss in adjacent teeth in the anterior
      maxillary esthetic zone resulting in black triangles (BTs). Then patients were randomly
      assigned to receive surgical regenerative periodontal treatment(test) or periodontal
      care(control)The test group was formed of 20 patients with 60 adjacent papillary defects . A
      control group was formed of 20 patients with 60 adjacent papillary defects.. A total of 480
      images obtained with the digital impressions . Evaluations of the test group were made
      preoperatively and at 3, 6 and 12 months postoperatively. For the control group, oral hygiene
      instruction was provided. Control group is evaluated by the same procedure with test group
      but the surgical part is not performed. Lost interdental papillary area (PA)were calculated.
      In the test group, the percentage of papillary filling, the presence of keratinized gingiva,
      the thickness of papillary gingiva, blood thrombocyte count and mean platelet volume
      values(MPV) were recorded.
    

Detailed description: 
      The treatment of open gingival embrasures, which are also known as black triangles (BT) or
      black holes, and cause esthetic, functional and phonetic problems in the anterior region, has
      become an area of interest in current periodontal treatment.Surgical, non-surgical and
      prosthetic methods are applied in the treatment of BT, which can be seen in more than half of
      adults. This study aimed to evaluate the efficacy of concentrated growth factor (CGF) in
      regenerating interdental papillary of multiple adjacent papillary black triangles (MAPBT)
      occured as a result of soft tissue loss. Interdental papillary regeneration was evaluated
      with the change in the area of interproximal spaces calculated on each of the intraorally
      scanned images obtained with digital impressions of the interproximal space with irregular
      borders.

      This controlled, examiner-blinded, randomized clinical study included 160 teeth of 40
      patients with 120 open embrasures which resulted from papillary loss in adjacent teeth in the
      anterior maxillary esthetic zone resulting in black triangles (BTs). The test group was
      formed of 20 patients with 60 adjacent papillary defects undergoing minimally invasive
      surgery for papillary regeneration with CGF. A control group was formed of 20 patients with
      60 adjacent papillary defects who were not included surgical treatment. A total of 480 images
      obtained with the digital impressions method of each interdental papillary region in each
      patient were uploaded to a special software. Evaluations of the test group were made
      preoperatively and at 3, 6 and 12 months postoperatively. For the control group, oral hygiene
      instruction was provided. Control group is evaluated by the same procedure with test group
      but the surgical part is not performed. Lost interdental papillary area (PA)were calculated
      between the two central teeth, between the lateral and central teeth, and between the lateral
      and canine teeth prior to the treatment and at pro-treatment periods of 3, 6 and 12 months in
      both of the groups. In the test group, the percentage of papillary filling, the presence of
      keratinized gingiva, the thickness of papillary gingiva, blood thrombocyte count and MPV
      values were recorded.
    

Intervention name(s): Concentrated Growth Factor
Intervention type(s): Procedure
Intervention description(s): surgical treatment with CGF for papilla regeneration
Intervention MeSH terms: Mitogens
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The test and control group was formed of patients with adjacent papillary defects In test group, elective minimally invasive surgery for papillary regeneration with CGF was performed. A control group was formed of patients with adjacent papillary defects who were not included to have surgical treatment.
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: CGF; lost interdental papilla