bioihbjkbjnl/mcl2 huggingface dataset:
Effect of Capnography Feedback During Cardiopulmonary Resuscitation (CPR ) on Patient's Outcome
Condition: Cardiopulmonary Arrest
MeSH terms: Heart Arrest
Study type: Interventional

Summary: 
      Compare the quality performance of rescuers and resuscitation outcomes of cardiac arrest
      patients in both groups with and without capnography feedback
    

Detailed description: 
      This study has done at Mashhad Ghaem Educational center. Two nurses and an anesthesia
      resident selected and trained according to the latest guidelines of CPR . In the control
      sample, with the declare of code 99 and attend the team on the patient's bedside, CPR begins
      and then every two minutes, return of the patient checks in the usual way. quality
      performance of rescuers ,Recovery or death of the patient and the result is recording. In the
      second phase , group members were educated how to use capnography (Comdek's MD-660P
      Oxi-Capnography) in CPR and guiding restoration efforts by it. with the code 99 and attend
      the team on the patient's bedside capnography uses and its waveforms will appear on the
      monitor device which is visible to all rescuers and the quality of performance is renewed
      based on the its guidance. The two groups patients for age, sex, initial rhythm of arrest,
      time of arrest until the first action, the time of arrest until the first shocks are
      comparing to control these factors influence on the outcome. quality performance of rescuers
      , resuscitation outcomes and CPR duration and relative factors in each of the groups were
      recorded and compared.
    

Intervention name(s): capnography feedback
Intervention type(s): Device
Intervention description(s): capnography feedback was used for management of the resuscitation and quality of cpr performance in rescuers and outcomes of the patients was measured.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Care Provider)
Keywords: cpr; feedback; capnography; outcome; quality; resuscitation
Phase 2a Study of Safety and Tolerability of SPN-810 in Children With ADHD and Persistent Serious Conduct Problems
Condition: Attention Deficit Disorder With Hyperactivity; Conduct Disorder
MeSH terms: Hyperkinesis; Attention Deficit Disorder with Hyperactivity; Conduct Disorder
Study type: Interventional
Phase: Phase 2

Summary: 
      It is hypothesized that, when given at the lowest effective dose, the favorable side effect
      profile combined with it's lower propensity for weight gain would make SPN-810 a candidate
      for treatment of persistent serious conduct problems in pediatric subjects with ADHD.
    


Intervention name(s): SPN-810; SPN-810; SPN-810; SPN-810
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): capsule taken three times a day; capsule taken TID; capsule taken TID; capsule taken TID
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: ADHD and conduct problems
Comparison of Pudendal Nerve Block and Caudal Block for Hypospadias in Young Children
Condition: Hypospadias and Epispadias
MeSH terms: Hypospadias; Epispadias
Study type: Interventional

Summary: 
      The purpose of this randomized blinded prospective study is to compare the analgesic efficacy
      and duration of a Pudendal Nerve Block (PNB) to a Caudal Block (CB) for pediatric patients,
      ages 6 months to 2 years, undergoing hypospadias repair.
    

Detailed description: 
      Hypospadias repair is one of the most common congenital malformations of the penis in the
      United States. It has an incidence of about 1 in 300 births. A combination of general
      anesthesia and a caudal block or general anesthesia combined with a pudendal nerve block are
      commonly used for hypospadias repair.

      In our institution, hypospadias repair is typically done in infants and children ages 6
      months to age two. A comparison of the efficacy of pudendal block versus the caudal block has
      not been undertaken in this younger population.
    

Intervention name(s): Caudal block; Bilateral Pudendal block
Intervention type(s): Procedure; Procedure
Intervention description(s): 1 cc per kg of 0.2% ropivicaine in the caudal space given before the start of surgery.; 0.5 cc per kg of 0.2% ropivicaine. Half of the volume given as a right pudendal block and the remaining volume given on the left pudendal nerve block given prior to the start of surgery
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: All Children will be randomly assigned to one of 2 groups of 30 patients each using a computer generated number table.
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: pudendal nerve block; hypospadias; caudal block
Measurement of Urinary Catabolites of PACs as Biomarkers of Consumption of Cranberry Extracts
Condition: Urinary Tract Infections
MeSH terms: Urinary Tract Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this cross over pilot study is to investigate the urinary catabolites of
      Proanthocyanidines (PACs) as biomarkers of cranberry extracts in healthy young women.
    


Intervention name(s): Cranberry extract
Intervention type(s): Dietary Supplement
Intervention description(s): The aim of this pilot study is to evaluate the urinary catabolites of PACs as a biomarker of consumption of cranberry extracts within 9 hours of intercourse. Once a week, for 3 weeks, the women will receive a sequence of 3 different cranberry extracts (72 mg, 36 mg and 2mg (placebo)). The participant will have to collect its urine for a period of 9 hours in 3 different containers (one different container for 3 hours).
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Cranberry; Proanthocyanidins; Urinary catabolites
Reliability, Validity of The Turkish Version of Craniofacial Pain and Disability Inventory
Condition: Temporomandibular Joint Disorders
MeSH terms: Joint Diseases; Temporomandibular Joint Disorders; Temporomandibular Joint Dysfunction Syndrome; Facial Pain
Study type: Observational

Summary: 
      This study, we are aim to make the Turkish version validity and reliability of the
      Cranifacial Pain and Disability Inventory, Jaw Functional Limitation Scale-20, and Jaw
      Functional Limitation Scale-8.
    

Detailed description: 
      Approximately 60% of individuals with temporomandibular disorders (TMD) reported increased
      pain intensity from midlevel to severe. This was seen at the end of the intervention or work
      related activities in the quarter of individuals. Therefore, the correct diagnosis of TMD is
      very important to reduce the economic cost. Craniofacial Pain and Disability Inventory
      (CF-PDI) is designed based on a biopsychosocial approach. Evidence has shown that CF-PDI is
      an well-structured, internal consistency, repeatable and valid, and that an objective outcome
      for the evaluation of pain and discomfort in patients with craniofacial pain. There is no
      Turkish version and validity study of CF-PDI. Each item is scored between 0-3. The total
      score ranged from 0 to 63, and a high score indicate a high level of discomfort. The aim of
      this study was to evaluate the validity and reliability of the Turkish version of CF-PDI. The
      study of validity and reliability is planned with 105 individuals with TMD. The
      sociodemographic characteristics of the individuals will be questioned by the investigators
      and then the patients will be evaluated with CF-PDI, Neck Disability Index (NDI), Tampa Scale
      for Kinesiophobia (TSK), Pain Catastrophizing Scale (PCS), Headache Impact Test-6 (HIT-6),
      Jaw Functional Limitation Scale (JFLS) (Turkish version) and Visual Analogue Scale (VAS). The
      test-retest will be re-administered by face-to-face interview technique after 1 week. The
      results will be analyzed using the SPSS version 22.0 computer package program.
    

Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients with temporomandibular disorders between the ages of 18-50
      
Keywords: Validity; Reliability; Temporomandibular Joint Disorders
Effects of Alternative Healthy Eating Index-Based Diet on Inflammatory Markers and Breast Density in Healthy Participants
Condition: Healthy Subject
Study type: Interventional

Summary: 
      This trial studies the effects of a dietary intervention based on the Alternative Healthy
      Eating Index (AHEI) on inflammatory markers and breast density in healthy participants. The
      AHEI is a quantifiable measure of diet quality designed to target food and macronutrient
      sources that are associated with chronic disease risk. Adherence to the AHEI may be
      associated with a reduction in inflammatory biomarkers and sex steroid hormone levels
      compared to other dietary patterns/scores.
    

Detailed description: 
      OUTLINE:

      DIETARY INTERVENTION: Participants receive dietary counseling with a dietitian in person or
      via telephone to support adherence to a diet based on the AHEI guidelines once weekly for up
      to 12 weeks.

      DUAL X-RAY ABSORPTIOMETRY (DXA) ONLY STUDY: Participants undergo DXA scan for breast density
      measurement at baseline and at 12 weeks.
    

Intervention name(s): Dietary Intervention; Dual X-ray Absorptiometry; Questionnaire Administration
Intervention type(s): Dietary Supplement; Procedure; Other
Intervention description(s): Receive dietary counseling; Undergo DXA scan; Ancillary studies
Other intervention name(s): Dietary Modification; intervention, dietary; Nutrition Intervention; Nutrition Interventions; Nutritional Interventions; BMD scan; bone mineral density scan; DEXA; DEXA Scan; dual energy x-ray absorptiometric scan; Dual Energy X-ray Absorptiometry; Dual X-Ray Absorptometry; DXA; DXA SCAN
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Breast - Female
The Effect of Chewing Duration on Blood Glucose Levels
Condition: Glucose, High Blood; Glucose, Low Blood
Study type: Interventional

Summary: 
      This study aims to assess the impact of speed of consumption of two starch-based foods
      varying in fibre content on blood glucose levels in normal healthy subjects. Furthermore, the
      mediating roles of salivary amylase and particle size on blood glucose levels will be
      studied. The study has a randomized cross-over design. Subjects consume two test-lunches
      (chick peas and brown rice) in duplicate on 8 different test days, at either long or short
      chewing duration. Glucose responses will be monitored via a continuous glucose monitoring
      device and expectorated boluses will be collected during each test day for assessments of
      amylase activity and food particle size.
    

Detailed description: 
      Research suggests that high glucose level variability and large dips in glucose levels may
      have a negative impact on cognitive function and self-reported wellbeing. The way food is
      consumed (e.g. chewing duration) may regulate blood glucose levels. The underlying mechanism
      that links consumption speed to metabolic responses, satiation and health is largely unknown.

      This study aims to assess the impact of speed of consumption of two starch-based foods
      varying in fibre content, on blood glucose levels in normal healthy subjects. Furthermore,
      the mediating roles of salivary amylase and particle size on blood glucose levels are
      studied.

      The study has a randomized cross-over design. Each subject consumes two different
      test-lunches (chick peas and brown rice) in duplicate at either long or short duration. Their
      breakfast will be standardized during these 8 test days. For a duration of 12 days, blood
      glucose levels will be monitored via a continuous glucose device. Furthermore expectorated
      boluses will be collected for assessment of amylase activity and food particle size.
    

Intervention name(s): Low glycaemic load, high fibrous product; High glycaemic load, low fibrous product
Intervention type(s): Other; Other
Intervention description(s): Test-lunch of 370 grams of chickpeas, seasoned with a herb- and spice mix to increase palatability. Glycaemic load 18.5. Consumed in duplicate.; Test-lunch of 257 grams of brown rice, seasoned with rice-oil and a herb- and spice mix to increase palatability. Glycaemic load 44.9. Consumed in duplicate.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Chewing behaviour
A Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics of DZD8586 in Healthy Adult Participants
Condition: Lymphoma, Non-Hodgkin
MeSH terms: Lymphoma, Non-Hodgkin
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a study in healthy adult participants. This is the first time this drug has ever been
      tested in human, and so it will help to understand what type of side effects may occur with
      this intervention. It will also measure the levels of drug in the body.
    

Detailed description: 
      This is a study in healthy adult participants. This is the first time this drug has ever been
      tested in human, and so it will help to understand what type of side effects may occur with
      this intervention. It will also measure the levels of drug in the body.
    

Intervention name(s): DZD8586; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Single dose of DZD8586. Starting dose of DZD8586 is 20mg. If tolerated, subsequent cohorts will test increasing doses of DZD8586.; A single oral dose of placebo will be given.
Allocation: Randomized
Intervention model: Sequential Assignment
Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Comparing Immunogenicity and Safety of Different Formulations of HBV-MPL Vaccine With Engerix™-B in Adults Aged 18-40 y
Condition: Hepatitis B
MeSH terms: Hepatitis B; Hepatitis
Study type: Interventional
Phase: Phase 2

Summary: 
      This study will evaluate the immunogenicity and safety of different formulations of the
      candidate HBV-MPL vaccine administered according to a 2-dose schedule and compare it to that
      of Engerix™-B administered according to a 3-dose schedule in order to determine the optimal
      dose of each component of the candidate HBV-MPL vaccine when administered at 0 and 6 months
    

Detailed description: 
      At the time of conduct of this study, the sponsor GlaxoSmithKline was known by its former
      name SmithKline Beecham
    

Intervention name(s): HBV-MPL vaccine; Engerix™-B
Intervention type(s): Biological; Biological
Intervention description(s): 5 different formulations, 2-dose intramuscular injection; 3-dose intramuscular injection
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Hepatitis B; HBV-MPL; Recombinant hepatitis B vaccine
Life-Stress Interview for Women With Chronic Urogenital Pain Conditions
Condition: Chronic Urogenital Pain
MeSH terms: Stress, Psychological
Study type: Interventional

Summary: 
      The goal of this study is to test the efficacy, feasibility, and acceptability of providing
      an experiential assessment interview that targets health, and emotional and stressful
      experiences in a tertiary care setting specializing in women's urology.
    

Detailed description: 
      In this randomized, controlled trial, the investigators will compare an interview condition
      to a wait-list control condition. The investigators hypothesize that helping individuals
      identify the links between their stress, emotions, and physical symptoms will likely increase
      their awareness and endorsement of the link between stress and physical symptoms, including a
      willingness to engage in stress management techniques. It is also expected that helping raise
      an individual's awareness about their symptoms, followed by an experience and expression of
      unexpressed emotion is likely to influence their physical and psychological well-being.
    

Intervention name(s): Life-Stress Interview
Intervention type(s): Behavioral
Intervention description(s): A life-stress interview which aims to help patients: a) disclose their stressful experiences and emotional conflicts, which might be contributing to their symptoms, b) learn about associations between their stress and physical symptoms; and c) learn about the potential value of experiencing and expressing their emotions related to these stressful situations
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Chronic Pelvic Pain; Interstitial Cystitis; Vulvodynia; Dyspareunia; Pelvic Floor Dysfunction; Emotional Processing
Effects of Low Level Laser Therapy (808nm) on Muscle Performance of Young Women Submitted to Physical Training
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The study hypothesis is an increase in muscle performance and a higher aerobic adaptation of
      young women submitted to chronic endurance training program associated to low level laser
      therapy when compared to chronic aerobic training alone.
    

Detailed description: 
      The study assessed women muscle performance in isokinetic dynamometry, ventilatory parameters
      such as ventilatory threshold, VO2Peak, VO2Max, Ventilation. Maximal load in cycle ergometer
      test (Balke's protocol), Borg Scale and Heart rate were assessed too.
    

Intervention name(s): Phototherapy by low level laser therapy
Intervention type(s): Device
Intervention description(s): Phototherapy by low level laser therapy during 9 weeks
Other intervention name(s): Laser; Laser therapy; Low level laser therapy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: low level laser therapy; muscle performance; fatigue index; endurance training; ventilatory threshold; VO2Max; VO2Peak
Bioequivalence of Orfadin 20 mg Compared to Orfadin 10 mg Capsules.
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the bioequivalence between Orfadin 20 mg and 10 mg
      capsules in healthy volunteers.
    

Detailed description: 
      This is an open, randomized 2-way crossover study in 12 healthy volunteers. Subjects will
      receive single oral 20 mg doses of nitisinone administrated as one 20 mg capsule or as two 10
      mg capsules of Orfadin. There will be a 3-week washout period between the doses.

      There will be a screening visit within 3 weeks prior to the first dose. During each treatment
      period, subjects will be admitted to the clinic from the afternoon on the day before drug
      administration (i.e., on Day -1) and remain at the clinic until the 48-hour post-dose blood
      sample has been collected in the morning of Day 3. They will then return for ambulatory visit
      in the morning of Day 4 (72-hour sample). A follow-up visit will take place 7-14 days after
      the last dose.
    

Intervention name(s): Nitisinone 20 mg; Nitisinone 10 mg
Intervention type(s): Drug; Drug
Intervention description(s): Nitisinone 20 mg capsules; Nitisinone 10 mg capsules
Intervention MeSH terms: Nitisinone
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Orfadin; Nitisinone; Bioequivalence
High-Risk HPV Infections in Women Aged 25 to 65
Condition: Papillomavirus Infections
MeSH terms: Infections; Communicable Diseases; Papillomavirus Infections
Study type: Observational

Summary: 
      The purpose of this study is to determine risk factors for HPV infections in 25 to 65 year
      old women who report having used internet dating websites in the past year.
    

Detailed description: 
      Whether older women are susceptible to acquiring new, persistent high-risk (HR) HPV
      infections from new sex partners is largely unknown. This is a pilot study of predictors of
      HR HPV infections in two populations of women aged 25 to 44 and 45 to 65 who have used
      internet dating websites in the past year. 400 women will be recruited and mailed kits for
      self-collecting vaginal specimens for HPV DNA testing. Women will self-collect two sets of
      vaginal specimens four months apart, and complete sexual behavior questionnaires at the time
      of each self-collection. If new HPV infections associated with recent new partners are
      detected in these women, this pilot data will be used to develop a larger longitudinal study
      of the acquisition and natural history of HR HPV infections in older women. This information
      is important for developing guidelines for HPV vaccine implementation and cervical cancer
      screening guidelines in populations of older women.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        25 to 65 year old women who date online
      
Biospecimen description: 
      Vaginal swab samples for HPV DNA testing
A Safety and Pharmacokinetic Study of AG-881 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C] AG-881 and Concomitant Intravenous Microdose of [13C315N3] AG-881
Condition: Healthy Male Participants
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this Phase I, open-label study is to evaluate the absorption, distribution,
      metabolism, excretion, absolute bioavailability, and to characterize the metabolites of
      AG-881 in healthy male participants following administration of a single oral dose of [14C]
      AG-881 and a concomitant intravenous microdose of [13C315N3] AG-881.
    


Intervention name(s): AG-881; [13C315N3]AG-881
Intervention type(s): Drug; Drug
Intervention description(s): Single oral dose of approximately 50 mg AG-881 (free form) containing approximately 100 microcuries (μCi) of [14C]AG-881.; Single IV microdose of approximately 100 μg.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Safety and tolerability; Pharmacokinetic study