Comparison of Inflammatory Cytokine Levels Between Single-port and Three-port Thoracoscopic Lobectomy in the Treatment of Non-small Cell Lung Cancersurgery on Perioperative Clinical Indexes、Inflammatory Reaction and Quality of Life Scores of Patients With Non-small Cell Lung Cancer
Condition: Video-assisted Thoracoscopic Surgery; Inflammatory Reaction; Life Scores
MeSH terms: Inflammation
Study type: Interventional

Summary: 
      Many recent studies have shown that surgical trauma will result in an immunosuppressive
      state. Combined with the effect of surgical stress, it will often lead to metabolic changes,
      systemic inflammatory response, and other problems. The body resists and removes the harmful
      factors through the inflammatory reaction. However, an excessive reaction will damage the
      normal tissues and cells of the body. The smooth recovery of the body needs to balance the
      degree of inflammatory reaction. Surgical patients will trigger different degrees of an
      inflammatory response due to different degrees of physical trauma, which runs through the
      process of postoperative recovery from the beginning of surgery and often prolongs the time
      of postoperative recovery. Reducing the intraoperative and postoperative inflammatory
      response of patients has always been the goal of surgeons, and a method is the reduction of
      surgical trauma.

      The successful experience of the first single-port thoracoscopic wedge resection of the lung
      in 2004 provided us with a new surgical idea. Subsequently, a large number of domestic and
      international studies and case reports show that single-port thoracoscopic surgery is safe
      and feasible in lobectomy and segmental resection. With the rapid development of single-port
      thoracoscopic surgery in recent years, the scope of application and clinical efficacy of the
      surgery are gradually becoming equivalent to the traditional three-port thoracoscopic
      surgery, which can ensure the safety of the operation and complete tumor resection, and has
      its own characteristics and advantages compared with the traditional three-port thoracoscopic
      surgery. The reduction of incisions can significantly improve the postoperative pain and
      recovery of patients and wound healing.

      In addition, single-port thoracoscopic surgery also has a subtle improvement in patients'
      intraoperative and postoperative inflammatory response compared with traditional three-port
      thoracoscopic surgery. In this study, we compared and analyzed the intraoperative and
      postoperative inflammatory factor levels of single-port thoracoscopic surgery and three-port
      thoracoscopic surgery in patients with non-small cell lung cancer (NSCLC). Through the
      comparison of the measured values, we further discussed the advantages of single-port
      thoracoscopic surgery in reducing inflammatory response and its application and promotion
      value in the treatment of patients with NSCLC compared with traditional three-port
      thoracoscopic surgery.
    


Intervention name(s): uni-portal VATS group; three port VATS group
Intervention type(s): Other; Other
Intervention description(s): patients received pulmonary lobectomy under general anesthesia by using uni-portal VATS method; patients received pulmonary lobectomy under under general anesthesia by using three port VATS method
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment