Comparison of USCOM Cardiac Output and Continuous Thermodilution Cardiac Output
Condition: Coronary Artery Disease
MeSH terms: Coronary Artery Disease
Study type: Observational

Summary: 
      It's reported that USCOM can be used to measured patients' CO and CI conveniently, accurately
      and not confined to place, because of it's no aggressive, it's accuracy is doubtful.
    

Detailed description: 
      18 post-CABG coronary artery disease patients receiving treatment in the SCCU of Beijing
      Chaoyang Hospital from March to July 2006, male (10) and female (8), with average age of
      61.71士10.07 years. Aortic regurgitation or stenosis was ruled out by preoperational color
      ultrasonic imaging, endocardiac shunt did not exist and there was no heart valve replacement
      in all the patients. For all the patients after operation, pericardial cavity or left thorax
      close drainage, small tidal volume (6-8ml/kg) capacity controlled ventilation of breathing
      machine, appropriate pressure support (10-15cmH2O) and appropriate positive end-expiratory
      pressure were applied. Intra-aortic balloon pumping (IABP) was not used. Institutional ethics
      approval was obtained for the conduct of the trial.

      All the patients received CABG under general anesthesia and non-extracorporeal circulation.
      Swan-Ganz CCO catheter (mbo 744HF75, USA) was set through right internal jugular vein or
      right subcalvian vein. The catheters were connected with VIGILANCE monitor after patients
      went back SCCU and the position of the catheters was adjusted. The bodyweight, height,
      instant heart rate, central venous pressure, invasive average aortic pressure and pulmonary
      wedge pressure of the patients were inputted into VIGILANCE monitor. VIGILANCE monitor
      automatically and intermittently displayed and saved the results of CO, CI, SVR, PVR and
      other hemodynamic parameters. VIGILANCE determined the hemodynamic parameters every
      40-55seconds based on the signal noise ratio.

      The period of USCOM monitoring time after CABG was 0.5-6hrs. Lowered the bed head and had the
      patients in horizontal position during the monitoring. Monitoring area was AV area. Turned on
      USCOM, selected AV mode, inputted the sex, height, bodyweight and birth date of the patients.
      Applied ultra transmission gel on the probe to let the probe contact the skin closely and let
      the probe point to the gluteal region nearly. USCOM screen automatically displayed the
      lateral border of the Doppler blood flow curve scanned with flow monitor and speaker
      displayed the acoustic signal of blood stream. The position, depth and direction of the probe
      were adjusted based on the figure signals and acoustic signals acquired with USCOM probe.
      Adjusted the sound volume, wave gain or contrast or turned the patient head gently. It
      indicated that the sound wave emitted by the probe had passed through aortic valve orifice or
      the root of aorta and the direction of sound beam paralleled to the blood flow through the
      aorta valve orifice when USCOM screen displayed maximum Doppler blood velocity wave and
      speaker displayed sharp and strong blood acoustic signals. The results were frozen and saved
      . Optimal measuring site, depth the probe was depressed down and direction of the probe were
      marked for the next measurement. Continuous 3-5 Doppler flow curves and the CO and CI
      measured on them were taken each time. The flow curves of one respiratory circle were taken
      for atrial fibrillation patients. For round probe, plane diameter was 1.5cm and frequency was
      3.3MHz. The probe was disinfected with Iodophors each time before and after the measurement.
      The data of patient height, bodyweight and age, and operation duration was acquired from
      anesthesia note. CO time intervals measured with the two methods were about 2min. There was
      at least 30min interval between each pair of CO. Three to four pairs of CO and CI data were
      taken for each patient.
    

Sampling method: Probability Sample
Study population: 
        18 post-CABG coronary artery disease patients receiving treatment in the SCCU of Beijing
        Chaoyang Hospital from March to July 2006, male (10) and female (8), with average age of
        61.71士10.07 years.For all the patients after operation, pericardial cavity or left thorax
        close drainage, small tidal volume (6-8ml/kg) capacity controlled ventilation of breathing
        machine, appropriate pressure support (10-15cmH2O) and appropriate positive end-expiratory
        pressure were applied. Institutional ethics approval was obtained for the conduct of the
        trial.
      
Keywords: CAD; CABG; CO; CI; thermodilution; USCOM