bioihbjkbjnl/mcl2 huggingface dataset:
Vegan or Animal Protein Ingestion on the Recovery of Muscle Function Following Exercise
Condition: Muscle Recovery
Study type: Interventional

Summary: 
      This study will assess the effect of daily post-exercise vegan (pea) and animal (whey)
      protein ingestion compared to placebo over 7 days of recovery from strenuous exercise. Muscle
      strength and soreness will be measured daily, and mechanisms underpinning recovery will be
      investigated in muscle biopsies taken 3, 24 and 48 hours after exercise.
    

Detailed description: 
      Strenuous exercise can cause muscle soreness and reduced muscle strength. It is widely
      acknowledged that nutritional supplements derived from animal protein sources, including whey
      from milk, aids recovery when taken immediately after strenuous exercise. However, the effect
      of vegan protein supplements are less understood, and how they affect recovery of strength
      and soreness is not known. This is an important area of research due to the increasing demand
      for plant-based protein.
    

Intervention name(s): Recovery animal (20g whey) protein supplement; Recover vegan (26g pea) protein supplement; Placebo (32g maltodextrin)
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Animal protein supplement consumed post exercise to aid recovery of muscle function following strenuous exercise.; Vegan protein supplement consumed post exercise to aid recovery of muscle function following strenuous exercise.; Placebo consumed post exercise to aid recovery of muscle function following strenuous exercise.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Other
Keywords: Muscle Strength; Musculoskeletal Physiology; Muscle, Skeletal; Whey Proteins; Plant Proteins; Dietary supplements
A Pilot Trial of Ranolazine to Treat Patients With Dilated Cardiomyopathy
Condition: Dilated Cardiomyopathy
MeSH terms: Cardiomyopathies; Cardiomyopathy, Dilated
Study type: Interventional
Phase: Phase 2

Summary: 
      Recent data suggest that areas of fibrosis and hibernating myocardium develop in patients
      with non ischemic dilated cardiomyopathy. Ranolazine is a new drug, developed to releave
      symptoms of angina in patients with stable coronary disease that is not suitable for surgical
      or percutaneous revascularization. It has been shown that in patients with stable coronary
      disease Ranolazine improves myocardial perfusion as shown with myocardial nuclear imaging.
      The aim of this trial is to evaluate effects of ranolazine on myocardial perfusion in
      patients with dilated cardiomyopathy.
    

Detailed description: 
      Recent data suggest that areas of fibrosis and hibernating myocardium develop in patients
      with non ischemic dilated cardiomyopathy. Ranolazine is a new drug, developed to releave
      symptoms of angina in patients with stable coronary disease that is not suitable for surgical
      or percutaneous revascularization. The main mechanism of action of Ranolazine is the
      inhibition of late I(Na) thus decreasing the Ca++ load in the cardiomyocites. Consequently
      oxygen consumption also decreases. It has also been shown that in patients with stable
      coronary disease Ranolazine improves myocardial perfusion as shown with myocardial nuclear
      imaging. The aim of this trial is to evaluate effects of ranolazine on myocardial perfusion
      in patients with dilated cardiomyopathy.

      Primary end-point: To determine wheather Ranolazine improves perfusion of the myocardium in
      patients with non-ischemic dilated cardiomyopathy.

      Secondary end-points: To determine wheather Ranolazine improves patients' NYHA functional
      class, excercise capacity, LV systolic and diastolic function and weather ranolazine affects
      supraventricular and ventricular arrhythmia occurance/frequency.
    

Intervention name(s): Ranolazine
Intervention type(s): Drug
Other intervention name(s): Ranexa
Intervention MeSH terms: Ranolazine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
The Effect of Rocking Bed on Preterm Newborns
Condition: Preterm; Preterm Birth; Nurse's Role
MeSH terms: Premature Birth
Study type: Interventional

Summary: 
      The study was planned to determine the effect of rocking bed applied to preterm newborns on
      comfort, physiological parameters and cerebral oxygenase level (rSO2).
    

Detailed description: 
      In most cultures, providing a newborn baby on the lap or in a rocking bed is mostly used to
      calm the baby. However, preterm babies who leave the uterus, which is their accustomed
      environment, in the early period, are positioned on a fixed bed such as an incubator or jeans
      in the NICU. These beds may reduce the infant's vestibular knowledge and the NICU environment
      may deprive infants of sensory stimuli. It has been suggested that because the vestibular
      system is one of the first systems to become functional, preterm infants may be more
      sensitive to stimulation of the vestibular system than other systems. When the studies were
      examined, it was seen that limited studies were conducted in the sample of preterm infants
      and the studies were not recent. Considering that babies are rocked in most cultures, it is
      thought that the evidence for the effects of the intervention on the baby is insufficient.
    

Intervention name(s): rocking bed group
Intervention type(s): Behavioral
Intervention description(s): Babies assigned to the intervention group first will be placed on a rocking bed after routine care such as feeding and diaper changes and when the newborn is stable. A rocking attempt will be applied to the baby placed in the rocking bed for 30 minutes. After 30 minutes, the baby will not be lifted from the bed and will lie in bed for 90 minutes. After a period of two hours in total, the babies will be cared for and fed. Then, babies will be quota and control group measurements will be made.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: The study was planned to be conducted in a randomized controlled crossover design. Infants meeting the inclusion criteria will be divided into two groups, group A and group B, according to block randomization. Groups were determined by drawing lots. (A= Rocking bed; B= Jeans) Accordingly, babies included in group A will be taken to the rocking bed first. Babies included in group B will be quoted first. Babies will be laid in these beds for an average of 2 hours. In cross-over design, a washout is recommended in order to control the carry over effect that may result from the interference. We assumed that the total time without interference would be sufficient to control the carryover effect, since the oscillation interference was only applied for half an hour in a two-hour sleep cycle, and there was routine maintenance and feeding cycles between measurements (average 20 min).
Masking: Single (Outcomes Assessor)
Primary purpose: Supportive Care
DERMALIX Efficacy on Diabetic Foot Ulcers
Condition: Diabetic Foot; Diabetic Foot Ulcer
MeSH terms: Diabetic Foot; Foot Ulcer; Ulcer
Study type: Interventional

Summary: 
      (DERMALIX) (Patent number: PCT/TR2014/000251) is a bioactive wound dressing that was
      developed by Ege University School of Pharmacy Department of Pharmaceutical Technology. This
      dressing has been categorised as Class III medical device. This clinical study will be
      conducted in patients with diabetic foot ulcers.
    


Intervention name(s): Standard Dressing; DERMALIX
Intervention type(s): Other; Device
Intervention description(s): Standard dressing is applied for treatment of diabetic foot ulcers; DERMALIX, a class III Medical Device will be applied in addition to standard dressing
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Open label, controlled, randomised, parallel arm study
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Diabetic Foot
Noninvasive Positive Pressure Ventilation in Moderate Acute Respiratory Distress Syndrome
Condition: Acute Respiratory Distress Syndrome
MeSH terms: Respiratory Distress Syndrome; Respiratory Distress Syndrome, Newborn; Acute Lung Injury; Syndrome
Study type: Interventional

Summary: 
      In order to identify the effect of noninvasive positive pressure ventilation (NPPV) on
      decreasing inflammatory response, improving the pathophysiological manifestation and reducing
      the morbidity and mortality in the moderate acute respiratory distress syndrome (ARDS)
      patients, the investigators conduct this clinical trial comparing NPPV with invasive
      mechanical ventilation in more than twenty ICUs in China.
    


Intervention name(s): noninvasive positive pressure ventilation (NPPV); invasive mechanical ventilation
Intervention type(s): Procedure; Procedure
Intervention description(s): Use NPPV to treat the ARDS patients,and we choose the NPPV ventilators in which the FiO2 can be fixed, for example: the BiPAP Vision or V60 of Phillip Respironics.; Intubate and give invasive mechanical ventilation to the other group patients when they are allocated at once.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: noninvasive positive pressure ventilation
Muscle Function and Its Biological and Physiological Determinants in Sickle Cell Disease
Condition: Sickle Cell Disease
MeSH terms: Anemia, Sickle Cell
Study type: Interventional

Summary: 
      Background : Sickle cell patients have profound remodeling of their muscle microcirculation
      networks with signs of amyotrophy. However, the consequences of these muscle alterations on
      the functional status of muscles are unknown. In addition, whether the poor physical fitness
      of sickle cell patients can be attributed, at least partly, to an hypothetical muscle
      dysfunction has never been tested.

      Purpose : this study will compare the muscle function of legs between sickle cell patients
      (SS and SC genotypes) and healthy individuals (AA genotype) before, during and after a short
      localized muscle endurance exercise.

      Abstract : Very recently, a study reported large differences between the muscle
      microcirculation networks of sickle cell patients compared to healthy individuals with
      decreased capillary density and higher proportion of large capillaries in the former
      population. In addition, the same study showed signs of amyotrophy in sickle cell patients.
      However, the muscle function of sickle cell patients has not been investigated and one may
      suggest that muscle dysfunction could participate in the decrease of physical fitness, in
      association with the hematological and hemorheological disorders, already reported in this
      population. The hypothesis is that muscle fatigue during a short localized muscle endurance
      exercise should be higher in sickle cell patients compared to healthy individuals, due to a
      greater recruitment of glycolytic fibers and a faster decrease of muscle oxygenation during
      exercise.
    


Intervention name(s): Blood sampling; Maximum Voluntary Contraction (MVC) test force; Localized muscle endurance test; Self-paced six-minute walk test
Intervention type(s): Biological; Other; Other; Other
Intervention description(s): Blood sampling will be performed to assess hematological and hemorheological parameters; Maximum Voluntary Contraction (MVC) test force will be performed before and after a localized muscle endurance test; Subject will perform 4 series of 20 submaximal dynamic contractions at 50% of the MVC interspaced with 1 min recovery.; Self-paced six-minute walk test will be conducted according to the guidelines of the American Thoracic Society
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Sickle Cell Disease; Muscle function; Hemorheological disorders
Study To Evaluate The Effect Of Multiple Doses of CTP-543 On The Pharmacokinetics Of Single Doses of Midazolam In Healthy Subjects
Condition: Health Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a single center, Phase 1, open-label, fixed-sequence, drug-drug interaction study to
      determine the effect of CTP-543 on the pharmacokinetics (PK) of midazolam in healthy adult
      subjects
    


Intervention name(s): Midazolam; CTP-543
Intervention type(s): Drug; Drug
Intervention description(s): 2 mg Day 1 and Day 16; 12 mg q12 hour for 14 consecutive days starting on Day 3
Intervention MeSH terms: Midazolam
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: CTP-543
Use of Autologous Serum Eye-drops as Tears in Patients With Recalcitrant Dry Eye
Condition: Xerophthalmia
MeSH terms: Xerophthalmia
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to examine the efficacy and safety of autologous serum eye drops
      in people with recalcitrant dry eye.
    

Detailed description: 
      A group of selected dry eye patients from the Singapore National Eye Centre who have
      exhausted the usual treatment options (lubricants, topical immunosuppressive and punctal
      occlusion) and not keen for tarsorrhaphy will be recruited. After informed consent, they will
      undergo plasmapheresis and start on daily autologous serum eyedrops for a period of 4 months.
      Clinical monitoring for standard dry eye parameters such as punctate corneal keratitis,
      Schirmers testing, tear break up time as well as severity and frequency of dry eye symptoms
      will be conducted. Tear inflammatory proteins captured on Schirmers paper pre and post
      treatment will be analysed as well.
    

Intervention name(s): Autologous serum eyedrops
Intervention type(s): Drug
Intervention description(s): 3 times a day for the duration of the study
Intervention MeSH terms: Ophthalmic Solutions
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Monocyte Chemoattractant Protein-1 2518A/G Polymorphism
Condition: Diabetic Retinopathy
MeSH terms: Retinal Diseases; Diabetic Retinopathy
Study type: Observational

Summary: 
      The pathogenesis of proliferative diabetic retinopathy (PDR) remains poorly understood.
      Recent studies have implicated that monocyte chemoattractant protein-1 (MCP-1) is associated
      with diabetic microvascular or macrovascular complications. However, the relationship between
      SNP polymorphism c.2518A/G in the MCP-1 gene with diabetic retinopathy remains controversial.
      In the present study, we evaluated the association of a single nucleotide polymorphism (SNP)
      in the MCP-1 gene with diabetic retinopathy (DR) and diabetic macular edema (DME) in Chinese
      population from Southern China with type 2 diabetes.
    

Detailed description: 
      The association between polymorphism of MCP-1 c.2518A/G and DR had been reported in Japan and
      Korea, but their opinion were inconsistent. However there is no report in China so far. This
      study was designed to clarify the relationship of polymorphism of MCP-1 c.2518A/G with type 2
      diabetes with or without DR. The relationship between MCP-1 c.2518A/G and different stage of
      DR has also been studied.This article proved that the MCP-1 c.2518G/G genotype is a
      susceptibility gene for DR in Chinese type 2 diabetic patients, especially the High-risk PDR.
      There is no association with DME and c.2518G/G.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        residents of a certain province
      
Biospecimen description: 
      Blood had been stored in -80℃.
Efficacy and Safety of Ibuprofen in Patients With Ankle Injuries
Condition: Pain
MeSH terms: Ankle Injuries
Study type: Interventional
Phase: Phase 3

Summary: 
      The objective of the study is to evaluate the efficacy and safety of Ibuprofen in patients
      with ankle injuries.
    

Detailed description: 
      The objective of the study is to evaluate the efficacy and safety of Ibuprofen versus placebo
      in patients for the treatment of pain related to uncomplicated ankle injuries.
    

Intervention name(s): Ibuprofen; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 3 times a day; 3 times a day
Intervention MeSH terms: Ibuprofen
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Mortality in Pediatric Intensive Care Unit
Condition: Intensive Care Units, Pediatric
Study type: Observational

Summary: 
      With the development of national economy and medical technology, patients can extend life
      rely on high-end medical facilities. At the same time, the continued treatment cannot bring
      benefits to children, even resulting in poor quality of life of children and bringing high
      medical costs. This makes the limited medical resources are unreasonable distributed.
      Research showed that PICU mortality rate halved over ten years ago, but the data did not
      include death cases who left hospital before death. However, the death number of out-hospital
      were more than death in-hospital. Therefore, the data cannot actually reflect China's
      mortality rate of PICU. The reason analysis was limited to the cause of the disease, and does
      not take the social, economic factors into account. This study include eight PICUs of
      children's Hospital PICU. Critically ill patients are prospectively studied from death risk
      factors, admission status, disease diagnosis, severity of illness, analyzing of the risk
      factors of death from disease diagnosis and death risk factors. In addition, we will
      illuminate the relationship of death and economic factor, especially for who died
      out-hospital after withdraw or stop treatment.
    


Intervention name(s): death
Intervention type(s): Other
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        ALL patients admitted to the PICU of eight study centers
Early Intermittent Intensive Insulin Therapy as an Effective Treatment of Type 2 Diabetes (RESET-IT Pilot Study)
Condition: Type 2 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 3

Summary: 
      Type 2 diabetes mellitus is a chronic metabolic disorder characterized by progressive
      deterioration in the function of the pancreatic beta-cells, which are the cells that produce
      and secrete insulin (the hormone primarily responsible for the handling of glucose in the
      body). The investigators propose a pilot randomized controlled trial to determine whether
      intermittent intensive insulin therapy is an effective therapeutic strategy that can preserve
      pancreatic beta-cell function and maintain glycemic control early in the course of type 2
      diabetes.
    

Detailed description: 
      In this study, eligible patients with type 2 diabetes will be randomized to either
      intermittent insulin therapy or continuous metformin therapy, after both arms have first
      undergone a short course of intensive insulin therapy. The hypothesis under study is whether
      intermittent insulin therapy can better preserve beta-cell function.
    

Intervention name(s): Intermittent insulin therapy; Continuous metformin
Intervention type(s): Drug; Drug
Other intervention name(s): Basal insulin glargine and pre-meal insulin lispro; Metformin
Intervention MeSH terms: Insulin; Insulin, Globin Zinc; Metformin; Insulin Glargine; Insulin Lispro
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: beta-cell function, type 2 diabetes, intermittent insulin
Plasticity-based Adaptive Cognitive Remediation for Alzheimer Disease
Condition: Older Adults, Aging Brain
MeSH terms: Alzheimer Disease
Study type: Interventional

Summary: 
      The primary objective of this study is to evaluate the effects of the experimental treatment
      (cognitive training) further outlined in this protocol on the cognitive abilities (e.g.,
      processing speed, attention, working memory, and executive function), brain functionality,
      functional status and quality of life of individuals with age-related cognitive decline as
      compared to a computer-based active control.
    

Detailed description: 
      The normal aging has a devastating effect on our cognitive ability to learn and remember, on
      the speed with which the investigators process information, and on our ability to reason. By
      2050, nearly 14 million individuals in the US will be living with Alzheimer's disease (AD),
      up from 5 million in 2013. AD is the most common cause of dementia, resulting in the loss of
      cognitive functions such as memory, reasoning, language, and cognitive, social, physical, and
      emotional control, to the extent that losses interfere with activities of daily living and
      necessitate continuous monitoring and care. Many studies now show that the processing
      machinery of the brain is plastic and remodeled throughout life by learning and experience,
      enabling the strengthening of cognitive skills or abilities. Research has shown that brief,
      daily computerized cognitive training that is sufficiently challenging, goal-directed and
      adaptive enables intact brain structures to restore balance in attention and compensate for
      disruptions in cognitive functioning. The study aims to understand how our computer program
      can affect cognition and attention in those with aging brain.
    

Intervention name(s): Computerized Plasticity-based Software; Commercially available Video Game
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Participants will be asked to use their assigned training program for forty minutes per session, up to five sessions per week, over 10 weeks (50 total sessions).; Participants will be asked to use their assigned video games for forty minutes per session, up to five sessions per week, over 10 weeks (50 total sessions).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science