bioihbjkbjnl/mcl2 huggingface dataset:
Linking Microcredit, Technology, and Promotion of IYCF Breastfeeding Guidelines in Bauchi State, Nigeria
Condition: Breast Feeding Exclusive; Initiation of Breastfeeding
Study type: Interventional

Summary: 
      The University of North Carolina (UNC) and Partners for Development (PFD), an American
      non-governmental organization, will conduct a 2-year cluster-randomized controlled trial in
      Bauchi State, Nigeria, to test the effectiveness of two behavior change strategies for
      increasing the proportion of participants who exclusively breastfeed their infants until 6
      months. The investigators will build upon PFD's existing microcredit and reproductive health
      program by adding face-to-face breastfeeding education during borrowers' meetings and
      bi-weekly cell phone breastfeeding messages. The hypothesis is that the control group will
      remain at the baseline level for exclusive breastfeeding to 6 months, while the intervention
      group will increase by 15%. The investigators will measure the effectiveness of the
      intervention by conducting baseline and final surveys with a cohort of 485 female borrowers
      who are pregnant at time 1 and who have a 6-month-old infant at time 2. The data will be
      analyzed using logistic regression adjusting for possible confounders and the effect of
      clustering.
    


Intervention name(s): Breastfeeding promotion intervention
Intervention type(s): Behavioral
Intervention description(s): Breastfeeding counseling during monthly microcredit meetings
Weekly cell phone messages about breastfeeding
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Breast feeding Exclusive; Initiation of breastfeeding
Asthma Digital Study
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional

Summary: 
      The Asthma Digital Study is a virtual, two-arm, randomized, controlled trial that will
      investigate the impact of digital tools on asthma symptom control, exacerbation frequency,
      healthcare utilization, and medical expenditures in adults with asthma.
    

Detailed description: 
      The Asthma Digital Study is a virtual, two-arm, randomized, controlled trial that will
      investigate the impact of digital tools on asthma symptom control, exacerbation frequency,
      healthcare utilization, and medical expenditures. Adults with asthma will be randomized to
      the passive or active arm in a 1:1 ratio.

      All participants will be sent two devices, at no cost-an Apple Watch and a Beddit Sleep
      Monitor. These are publicly available, commercial devices that have not been modified for
      this study.

      The study will be administered largely through a customized version of CareEvolution's
      MyDataHelps app (the "Study App"). Access to the Study App will be provided to all
      participants. It will be used to administer informed consent and electronic patient reported
      outcome (ePRO) measures, and for other study purposes. Only active arm participants will have
      access to Study App features designed to support asthma self-management. These features
      include "smart nudges" based on device data, symptom and trigger tracking, evidence-based
      education, summaries of health metrics gathered from the Apple Watch and Beddit Sleep
      Monitor, in-app medication refill resources, as well as other resources.

      The study duration is 2 years. Participants can keep using the Study App and devices after
      Year 1, though this is not required. Primary analyses will utilize Year 1 data only. During
      Year 2, data collection will continue where available, though fewer data will be collected
      because use of digital tools is not required during Year 2, and health coverage changes may
      cause loss of access to claims data.
    

Intervention name(s): Digital Tools for Asthma Self-Management
Intervention type(s): Other
Intervention description(s): Please see description of active study arm.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Efficacy, Safety, and Tolerability Study of ACT-129968 in Patients With Seasonal Allergic Rhinitis
Condition: Seasonal Allergic Rhinitis
MeSH terms: Rhinitis; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal
Study type: Interventional
Phase: Phase 3

Summary: 
      This study will assess the efficacy and safety of ACT-129968 in adolescent, adult and elderly
      patients with seasonal allergic rhinitis, due to mountain cedar pollen.
    


Intervention name(s): ACT-129968; Placebo; Cetirizine
Intervention type(s): Drug; Drug; Drug
Intervention description(s): daily tablets; matching placebo tablets and capsules; daily capsules
Other intervention name(s): Setipiprant
Intervention MeSH terms: Cetirizine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: seasonal allergic rhinitis
Nordic Hamstring and Repeated-sprint Ability in Football (Soccer) Players
Condition: Repeated-sprint Ability
Study type: Interventional

Summary: 
      The purpose of the study is to investigate the efficacy of a 10-week intervention, using the
      Nordic Hamstring exercise, on repeated-sprint ability in male sub-elite football players. The
      primary outcome measure is total sprint time during 4x6 sprint of 10 meters measured using
      dual-beam photoelectric cells. Additionally, eccentric knee flexor strength is measured using
      the Nordbord hamstring strength measure. The hypothesis is that strength training of the knee
      flexor muscles elicited by the Nordic Hamstring exercise will result in enhanced repetitive
      sprint-ability expressed as a decrease in total sprint time. Furthermore, baseline data is
      used to assess to correlation between eccentric hamstring strength and active hamstring
      flexibility AND sprint performance.
    


Intervention name(s): Nordic Hamstring; Control
Intervention type(s): Other; Other
Other intervention name(s): Hamstring lowers; Nordic lowers; Hamstring Curl
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Other
Keywords: Repeated-sprint ability; Nordic Hamstring exercise; Eccentric hamstring muscle strength
Development of Minidose Inje Cocktail Method for Simultaneous Evaluating Five Cytochrome P450 Isoforms in Human
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The investigators objectives were developing mini dose five-drug cocktail regimen to evaluate
      potential drug-drug interactions associated with use of a cocktail of caffeine, losartan,
      omeprazole, dextromethorphan, and midazolam for simultaneous assessment of CYP1A2, CYP2C9,
      CYP2C19, CYP2D6, and CYP3A activities.
    

Detailed description: 
      The investigators objectives were developing minidose five-drug cocktail regimen to evaluate
      potential drug-drug interactions associated with use of a cocktail of caffeine, losartan,
      omeprazole, dextromethorphan, and midazolam for simultaneous assessment of CYP1A2, CYP2C9,
      CYP2C19, CYP2D6, and CYP3A activities.
    

Intervention name(s): Omeprazole; Losartan; Dextromethorphan; Cocktail; Midazolam; Caffeine
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Thirteen healthy male subjects were given oral doses of 200 μg omeprazole, 2 mg losartan and 2 mg dextromethorphan individually and in combination of five drugs (cocktail) every other days.; Thirteen healthy male subjects were given oral doses of 200 μg omeprazole, 2 mg losartan and 2 mg dextromethorphan individually and in combination of five drugs (cocktail) every other days.; Thirteen healthy male subjects were given oral doses of 200 μg omeprazole, 2 mg losartan and 2 mg dextromethorphan individually and in combination of five drugs (cocktail) every other days.; Group A : Thirteen healthy male subjects were given oral doses of 200 μg omeprazole, 2 mg losartan and 2 mg dextromethorphan individually and in combination of five drugs (cocktail) every other days.
Group B : Thirteen healthy male subjects received 100 μg midazolam and 2 mg caffeine individually followed by five-drugs cocktail every two days.; Thirteen healthy male subjects received 100 μg midazolam and 2 mg caffeine individually followed by five-drugs cocktail every two days.; Thirteen healthy male subjects received 100 μg midazolam and 2 mg caffeine individually followed by five-drugs cocktail every two days.
Other intervention name(s): The drug was made by Yuhan corp.; The drug was exclusively made for this study.; The drug was made by Yuhan corp.; The drug was exclusively made for this study.; The drug was made by Yuhan corp.; The drug was exclusively made for this study.; All of the drugs were made by Yuhan corp.; All of the drugs were exclusively made for this study.; The drug was made by Yuhan corp.; The drug was exclusively made for this study.; The drug was made by Yuhan corp.; The drug was exclusively made for this study.
Intervention MeSH terms: Losartan; Midazolam; Dextromethorphan; Caffeine; Omeprazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Volunteers
A Randomised, Single Centre, Double-blind, Two-period, Cross-over Trial in Healthy Subjects Investigating the Bioequivalence Between Subcutaneous Injections of Semaglutide Produced by Two Manufacturing Processes
Condition: Diabetes; Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This trial is conducted in Europe. The aim of the trial is to investigate the bioequivalence
      (assessment of the expected biological equivalence of two pharmaceutical drug products with
      identical active ingredient) between subcutaneous injections of semaglutide produced by two
      manufacturing processes.
    


Intervention name(s): semaglutide
Intervention type(s): Drug
Intervention description(s): For subcutaneous (s.c., under the skin), single dose administration at two separate dosing visits.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: mm
Effects of a Computer Game on Activity Choices
Condition: Overweight
MeSH terms: Overweight
Study type: Observational

Summary: 
      The study seeks to discover whether peer rejection increases the value of food relative to
      peer interaction in overweight individuals. After playing a computer game that randomly
      simulates peer rejection or peer acceptance, participants will play another computer game
      that will assess the value of food and social interactions.

      Overweight individuals may be more likely to resort to food in moments of distress and less
      likely to choose to interact with a peer to reestablish their sense of belongingness.
    


Sampling method: Probability Sample
Study population: 
        Adults between the ages of 18-50
      
Keywords: peer rejection; obesity; amount of food chosen; amount of social time chosen
Out-of Pocket Payments With Lymphedema in France
Condition: Primary Lymphedema Secondary Lymphedema
MeSH terms: Lymphedema
Study type: Observational

Summary: 
      Lymphedema is a frequent and chronic condition posing a high burden on patients. Clinical
      guidelines emphasize the role of compression therapy by prescription medical devices. Even in
      a mandatory publicly funded health insurance system, out-of-pocket payments (OOPP) may exist
      due to the price and reimbursement setting processes. OOPP may threaten the equity of care
      and drive patients to forgo care. Our aim was to analyze the distributive effects of OOPP for
      lymphedema patients in France.

      A prospective, multicenter study will be conducted in France in 2014 on patients with
      lymphedema. Household ability to pay will be specified by net income and OOPP will be
      assessed prospectively over 6 months for outpatient care (visits, drugs, medical devices,
      nursing care, biological tests, imaging, physiotherapy and transportations). Both mandatory
      and voluntary health insurance reimbursements will be considered. We will combine
      concentration curves and concentration indices to assess the distributive effects.
    


Intervention name(s): Standard care
Intervention type(s): Other
Other intervention name(s): Standard care including medical visits , drugs and medical devices
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        All consecutive patients meeting the inclusion criteria will be included in each
        participating centre during the inclusion phase
Blended Depression Therapy: Cognitive Behaviour Therapy Face-to-face and Via Internet
Condition: Major Depressive Disorders
MeSH terms: Depression; Depressive Disorder; Depressive Disorder, Major
Study type: Interventional

Summary: 
      To asses the clinical effectiveness of blended cognitive behavior therapy (CBT): face-to-face
      and internet-based treatment for adults with Major Depressive Disorder (MDD) in primary care
      compared to treatment as usual.
    

Detailed description: 
      The study is part of a EU-project. Participants are recruited via regular routes from primary
      care settings. Following the Mini International Neuropsychiatric Interview (M.I.N.I.)
      participants will be randomly allocated to either blended treatment for 10 sessions/weeks or
      to treatment as usual. We will include 150 participants in total.
    

Intervention name(s): Cognitive behavioral therapy; Treatment as usual
Intervention type(s): Behavioral; Other
Intervention description(s): CBT based on behavioral activation and cognitive therapy techniques including homework; Treatment as usual in primary care including antidepressants and counselling
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Major Depressive Disorder (MDD); Blended treatment; Cognitive behavior Therapy (CBT); Face-to-face; internet-based treatment
Comparison of Thoracic Manipulation and Muscle Energy Technique in Non-specific Mechanical Neck Pain
Condition: Neck Pain
MeSH terms: Neck Pain
Study type: Interventional

Summary: 
      To compare the effects of Thoracic manipulation and MET in relieving pain.in improving Range
      of motion and in improving functional disability.
    

Detailed description: 
      Neck pain is a common musculoskeletal disorder. Mechanical neck pain is also known as
      non-specific neck pain and is defined as the pain anywhere within the region bounded
      superiorly by superior nuchal line, inferiorly by an imaginary line through the tip of first
      thoracic spinous process and laterally by sagittal plane tangential to the lateral borders of
      the neck in which pain is provoked by sustained neck posture, neck movement, pain on
      palpation of cervical musculature without pathologies. In most patients, neck pain can be a
      common cause of disability: it is associated with daily activity limitations, reduction of
      work productivity and decrease in quality of life. Mechanical neck pain is commonly seen in
      people involved in occupation like computer processing, clerical job, students and people
      with sedentary life style awkward occupational posture, heavy lifting and physically
      demanding work.

      thoracic spine manipulation (TSM) is defined as a high-velocity/low amplitude movement or
      "thrust" directed at any segment of the thoracic spine.

      Muscle energy technique (MET) is a method of treatment that involves the voluntary
      contraction of subject's muscles in a precisely controlled direction, against a counterforce
      and producing post isometric relaxation through the influence of the Golgi tendon. MET is
      used to decrease pain, stretch tight structures muscle and fascia, reduce muscle tone,
      improve local circulation, and mobilize joint restriction
    

Intervention name(s): thoracic Manipulation Posterior anterior and conventional therapy; Muscle Energy Technique (PIR) and conventional treatment
Intervention type(s): Other; Other
Intervention description(s): A high-velocity, end range force directed to both sides of the respective zygapophyseal joint as indicated by the segmental examination. This procedure will be performed for a maximum of two attempts. When a cracking sound occurred, the therapist will move on to the next segmental restriction from an upper level to a lower level.; sustain the Isometric contraction for 7-10 and hold the breath. Then the patient will be asked to breathe out and relax while the therapist stretches further up to the neck barrier and hold this for 30 seconds.3 to 5 repetition
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Pain; thoracic manipulation; muscle energy technique; disability; range of motion
The Effect of Different I:E Ratio on Gas Exchange of Patients Undergoing Gynecologic Laparoscopic Surgery With Trendelenburg Position
Condition: Uterine Myoma; Ovarian Cyst; Laparoscopic Gynecologic Surgery
MeSH terms: Ovarian Cysts; Leiomyoma; Myofibroma
Study type: Interventional

Summary: 
      In patients undergoing gynecologic laparoscopic surgery with trendelenburg position, the
      disturbance of pulmonary gas exchange frequently occurs due to high intra-abdominal pressure.
      The investigators tried to evaluate the effect of various inspiratory to expiratory ratio on
      pulmonary gas exchange by randomized controlled trial.
    

Detailed description: 
      In patients undergoing gynecologic laparoscopic surgery with trendelenburg position, the
      disturbance of pulmonary gas exchange frequently occurs due to high intra-abdominal pressure.
      During the laparoscopic surgery with abdominal gas insufflation, gas exchange disturbance
      such as CO2 retention, hypoxemia occurs in addition to high plateau airway pressure. The
      usual strategy against these kinds of problem is pressure-controlled ventilation. However,
      the gas exchange problem especially CO2 retention can not be solved in some cases. The
      inverse-ratio ventilation (IRV), which prolongs the inspiratory time greater than expiratory
      time, can be applied for adult respiratory distress syndrome. The efficacy of IRV is to
      improve gas-exchange status by increasing mean airway pressure and alveolar recruitment.
      There have been several clinical investigations which applied IRV during general anesthesia.
      However, there have been debates about the effect of IRV during general anesthesia.
      Therefore, we tried to apply the IRV for subjects undergoing laparoscopic surgery, and
      evaluate the effect of different I:E ratio on the pulmonary gas exchange and respiratory
      mechanics.
    

Intervention name(s): conventional I:E ratio; 1:1 ratio; 2:1 group; external PEEP
Intervention type(s): Procedure; Procedure; Procedure; Procedure
Intervention description(s): conventional I:E ratio of 1:2 is applied.; I:E ratio of 1:1 is applied.; Inverse I:E ratio of 2:1 is applied.; external positive end-expiratory pressure of 5 cmH2O is applied.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Keywords: laparoscopic gynecologic surgery; gas exchange; inspiratory time; expiratory time; I:E ratio
Comparison of Efficacy and Safety of Norgestimate-ethinyl Estradiol and Cyproterone Acetate-ethinyl Estradiol in the Treatment of Acne Vulgaris
Condition: Acne Vulgaris
MeSH terms: Acne Vulgaris
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study was to evaluate the effectiveness and safety of
      norgestimate-ethinyl estradiol as comparted with cyproterone acetate-ethinyl estradiol among
      female patients with moderate acne vulgaris.
    

Detailed description: 
      This study was to evaluate the efficacy and safety of TriCilest as comparted with Diane-35
      among female patients with moderate acne vulgaris. The study design was double-blind,
      randomized, parallel and active controlled. The sponsor planned to recruit approximately 50
      patients to complete 40 evaluable patients. At the end of the study, a total of 48 patients
      were randomized.

      TriCilest (noregestimate-ethinyl estradiol), 0.18mg-0.035mg or 0.215mg-0.035mg or
      0.25mg-0.035mg, Oral admistration, The duration was three consecutive menstrual cycles.
    

Intervention name(s): Norgestimate-ethinyl estradiol; Cyproterone acetate-ethinyl estradiol
Intervention type(s): Drug
Intervention MeSH terms: Moxifloxacin; Cyproterone Acetate; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Ethinyl Estradiol; Norgestimate; Norgestimate, ethinyl estradiol drug combination; Estradiol; Polyestradiol phosphate; Cyproterone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: TriCilest; acne vulgaris
Multiple-dose Escalation Clinical Study of VC005 Tablets in Healthy Subjects
Condition: Inflammatory Bowel Diseases
MeSH terms: Inflammatory Bowel Diseases
Study type: Interventional
Phase: Phase 1

Summary: 
      This clinical trial is a randomized, double-blind, single-center, placebo-controlled and
      multiple-dose escalation Pharmacokinetics study
    

Detailed description: 
      The main purpose of this trial is to evaluate the Safety, Tolerance, Pharmacokinetics and
      Pharmacodynamics of VC005 Tablets in healthy subjects.
    

Intervention name(s): VC005 tablets; VC005 Placebo tablets
Intervention type(s): Drug; Drug
Intervention description(s): VC005 groups repeat administration for 7 days; VC005 placebo groups repeat administration for 7 days
Allocation: Randomized
Intervention model: Sequential Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: healthy subjects
Upper Cross Syndrome Rehabilitation Strengthening of the Dorsal Erector Muscles
Condition: Neck Pain
MeSH terms: Neck Pain
Study type: Interventional

Summary: 
      The purpose of this study is to determine which treatment is more effective for chronic neck
      pain associated with Upper Cross Syndrome.
    

Detailed description: 
      Patients will divided in two groups, control and intervention. Control Group will do
      exercises of strengthening of Deep Cervical Flexors, Shoulder External Rotators and Adduction
      of Scapulae.

      Intervention group will do the same plus Strengthtening of Erector Thoracic.
    

Intervention name(s): Strengthening exercises programme
Intervention type(s): Other
Intervention description(s): Strengthening exercises for Deep Cervical Flexors, Shoulder external rotators, scapular adductors and thoracic erector muscles
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: chronic neck pain; upper crossed syndrome; rounded shoulder posture