The Effectiveness of Different Doses of Hyaluronic Acid Injections in Knee Osteoarthritis.
Condition: Knee Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional

Summary: 
      The aim of this prospective, randomized, controlled multi-centre study is to compare the
      effectiveness and safety of three and five injections of standard linear hyaluronic acid (HA)
      versus single HA injection in terms of pain intensity and functional status in patients with
      knee osteoarthritis.
    

Detailed description: 
      Osteoarthritis (OA) is the most common form of chronic joint disease. A treatment option for
      patients diagnosed with knee osteoarthritis is intra-articular hyaluronic acid therapy. In
      this prospective, randomized controlled, single blind, interventional study, a total of 90
      patients with stage 2-3 knee osteoarthritis according to the kellgren lawrence classification
      who meet the eligibility criteria will be enrolled in the study. Eligible participants will
      be randomly assigned to one of the three groups using computer-generated random numbers. In
      the first group, 2 ml linearly linked 20 mg 1.0% hyaluronic acid injection in 5 sessions, in
      the second group 2 ml linearly linked 32 mg 1.6% hyaluronic acid injection in 3 sessions and
      in the third group 2.4 ml linearly linked 48 mg 2.0% hyaluronic acid injection in a single
      sessions will be applied. Participants are going to evaluate before injection, at the 1-month
      follow-up, at the 3-month follow-up and 6-month follow-up using the visual analog scale (VAS)
      scores for pain during activity, at rest, and at night, with the Western Ontario and McMaster
      Universities Osteoarthritis Index (WOMAC) change in pain, stiffness and physical function
      score, the change in the Timed Up and Go Test (TUG) time and the change in the patient's
      daily activities with the numerical global patient assessment scale.
    

Intervention name(s): Intra-articular 20 mg, 1.0% Hyaluronic Acid Injection; Intra-articular 32 mg, 1.6% Hyaluronic Acid Injection; Intra-articular 48 mg, 2.0% Hyaluronic Acid Injection
Intervention type(s): Other; Other; Other
Intervention description(s): Intra-articular 2 ml linearly linked 20 mg 1.0% hyaluronic acid injection in 5 sessions will be applied.
As a home exercise program, hamstring and quadriceps stretching, quadriceps isometric strengthening, short arc terminal extension exercises will be given at least three days a week with 3 sets of 10 repetitions.; Intra-articular 2 ml linearly linked 32 mg 1.6% hyaluronic acid injection in 3 sessions will be applied.
As a home exercise program, hamstring and quadriceps stretching, quadriceps isometric strengthening, short arc terminal extension exercises will be given at least three days a week with 3 sets of 10 repetitions.; Intra-articular 2,4 ml linearly linked 48 mg 2.0% hyaluronic acid injection in single session will be applied.
As a home exercise program, hamstring and quadriceps stretching, quadriceps isometric strengthening, short arc terminal extension exercises will be given at least three days a week with 3 sets of 10 repetitions.
Intervention MeSH terms: Hyaluronic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Knee Osteoarthritis; Linear Hyaluronic Acid