Correlation of Glucose and Lipid Metabolism Levels With Vitiligo
Condition: Metabolism Disorder, Glucose; Metabolism Disorder, Lipid; Vitiligo
MeSH terms: Vitiligo; Metabolic Diseases; Glucose Metabolism Disorders; Lipid Metabolism Disorders
Study type: Observational [Patient Registry]

Summary: 
      The goal of this observational study is to compare serum glucose and lipid metabolism levels
      between health volunteers and vitiligo patients. The main question it aims to answer is
      whether vitiligo is related to glucose and lipid metabolism disorders. Participants will
      complete a vitiligo questionnaire and test serum levels of indicators related to glucose and
      lipid metabolism. Researchers will compare vitiligo patients with healthy volunteers to see
      if there is a correlation between vitiligo and disorders of glucose and lipid metabolism.
    

Detailed description: 
      Vitiligo is a common autoimmune skin disease, which causes white spot formation due to
      destruction of epidermal melanocytes, severely affecting the physical and mental health of
      patients, but treatment is extremely difficult due to unclear pathogenesis. Studies have
      reported that patients with type I diabetes mellitus combined with vitiligo, the risk of
      metabolic syndrome, diabetes mellitus, elevated lipids, and obesity in vitiligo patients is
      higher than that of healthy controls, and other studies have reported that vitiligo lesions
      in patients with hypercholesterolemia combined with vitiligo treated with simvastatin get
      rapid skin color, suggesting that there is a correlation between glucose and lipid metabolism
      and the vitiligo disease, but as of now there is no research study on the correlation of
      glucose and lipid metabolism and vitiligo pathogenesis, much less large data can be analyzed
      for reference. Therefore, there is an urgent need to study the metabolic profile of vitiligo
      patients and utilize the basic research platform to explore the role of abnormal body
      metabolism in the onset or progression of vitiligo.

      This study intends to conduct a cross-sectional study, using questionnaires to collect and
      register vitiligo patients' disease information, etc., to establish a database of study
      subjects, and to collect peripheral blood samples from vitiligo patients to test the levels
      of key indicators of glycolipid and lipid metabolism, and to analyze their correlation with
      clinical features, disease activity, and treatment of vitiligo. Through the above studies,
      clinical evidence for the involvement of abnormalities in glycolipid and lipid metabolism in
      the development of vitiligo was provided.
    

Intervention name(s): Collecting blood samples
Intervention type(s): Other
Intervention description(s): Peripheral blood was collected from the study subjects and blood glucose, glycosylated hemoglobin, triglycerides, total cholesterol, high-density lipoprotein and low-density lipoprotein levels were measured in the peripheral blood.
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        We recruited patients with clinically diagnosed vitiligo and age- and sex-matched healthy
        volunteers.
      
Biospecimen description: 
      Blood samples of vitiligo patients and healthy volunteers
    
Keywords: Vitiligo; Glucose; Lipid