bioihbjkbjnl/mcl2 huggingface dataset:
The Influence of Eccentric Training on the Volume and Vascularisation of the Rotator Cuff in Patients With Rotator Cuff Tendinopathy and Healthy Subjects
Condition: Rotator Cuff Tendinopathy
MeSH terms: Tendinopathy; Neovascularization, Pathologic
Study type: Interventional

Summary: 
      Patients with rotator cuff tendinopathy make up a large part of the population in
      physiotherapy practice. The rotator cuff, a shoulder muscle group, plays an important role in
      causing pain. Tendons suffer large compression and friction, which can lead to degeneration
      of these tendons. Rehabilitation often leads to unsatisfying results.

      In Achilles and patella tendinopathy, a new training program called eccentric training has
      shown very good results. Eccentric training contains exercises during which a force has to be
      resisted while the muscle lengthens instead of shortens. This would have a larger influence
      on tendon tissue. Some small studies also show promising results of eccentric training in
      patients with rotator cuff tendinopathy but the mechanisms behind these results remain
      unclear.

      To investigate this, 30 patients with rotator cuff tendinopathy and 30 healthy subjects will
      be evaluated before and immediately after performing the exercise. Three measurements will be
      done: ultrasonographic measurement of tendon thickness, power Doppler imaging and measurement
      of microcirculation around the tendon with Oxygen to see. All measurements are non-invasive,
      pain free and without risks for the human body.
    


Intervention name(s): Eccentric exercise
Intervention type(s): Behavioral
Intervention description(s): Patients and healthy subjects will perform an eccentric exercise during which a weight is lifted along the body and lowered with an extended arm at a slow speed. Weight is determined, based on pain in patients and based on force in healthy subjects.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Progesterone Induced Blocking Factor Expression Levels in Endometrial Cancer Cells.
Condition: Progesterone Induced Blocking Factor in Endometrial Cancer
MeSH terms: Endometrial Neoplasms
Study type: Observational

Summary: 
      Immune system suppression effect of Progesterone Induced Blocking Factor(PIBF), it could be
      questionable whether tumor cells express PIBF for escape of immune system. There are some
      studies in the literature that evaluate PIBF expression of different malign cells (e.g.
      glioblastoma multiforme as a malign central nerve system, leukemia, astrocytoma as a primary
      brain tumor, lung cancer and chorionic carcinoma). According to previous studies PIBF has
      been used as an anti-tumor immune suppressor by tumor cells. There is no data about the PIBF
      expression of endometrial tumor cells. Therefore, the investigators aim to determine the PIBF
      expression levels in the endometrial cancer cells.
    

Detailed description: 
      This retrospective controlled study will be conducted at both Obstetrics and Gynecology
      clinics and Pathology clinics of Kayseri Training and Research Hospital. This study will be
      conducted with the use of formalin fixed paraffin embedded tissue blocks
      immunohistochemically to determine the PIBF expression levels in the samples. There are three
      groups in this study; endometrial cancer, endometrial hyperplasia and normal endometrium and
      each of the groups contained 20 paraffin embedded blocks provided form the Pathology clinic
      of Kayseri Training and Research Hospital archives.
    

Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        There are three groups in this study; endometrial cancer,endometrial hyperplasia and normal
        endometrium and each of the groups contained 20 paraffin embedded blocks provided from the
        Pathology clinic of Kayseri Training and Research Hospital archives.
      
Keywords: Progesterone Induced Blocking Factor; Endometrial Cancer
Efficacy and Safety of 2 Dose Regimens of TEV-48125 Versus Placebo for the Preventive Treatment of Episodic Migraine
Condition: Migraine
MeSH terms: Migraine Disorders
Study type: Interventional
Phase: Phase 3

Summary: 
      The study is being conducted to evaluate two doses of TEV-48125 in adult patients with
      episodic migraine
    


Intervention name(s): Fremanezumab; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Fremanezumab was provided as a sterile, unpreserved, aqueous solution for injection, 225 mg/1.5 mL pre-filled syringe for single-use administration.
The 675 mg dose was given as 3 injections; doses of 225 mg were given as a single injection. Study drug was administered at the clinical site.; Placebo 1.5 mL pre-filled syringes identical in appearance to active intervention. Study drug was administered at the clinical site.
Other intervention name(s): TEV-48125, anti-calcitonin gene-related peptide (anti-CGRP)
Intervention MeSH terms: Calcitonin; Calcitonin Gene-Related Peptide; Katacalcin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Scopolamine Challenge Study
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      It is hypothesized that PF-05212377 (SAM-760) will reverse scopolamine induced cognitive
      impairments in healthy adults subjects.
    

Detailed description: 
      Proof of mechanism
    

Intervention name(s): Placebo; Scopolamine; PF-05212377; Scopolamine; PF-05212377; scopolamine; PF-05212377; scopolamine; Donepezil; Scopolamine
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Capsule, single dose, oral, 1 day; injectable subcutaneous formulation, single dose, 1 day; 5 mg, PF-05212377, capsule, single dose, 1 day; injectable subcutaneous formulation, single dose, 1 day; 20 mg, capsule PF-05212377, single dose, 1 day; injectable subcutaneous formulation, single dose, 1 day; 60 mg PF-05212377, capsule, single dose, 1 day; injectable sub cutaneous formulation, single dose, 1 day; Tablet, 10mg, single dose, 1 day; injectable sub cutaneous formulation, single dose, 1 day
Intervention MeSH terms: Scopolamine; Donepezil; Butylscopolammonium Bromide
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Other
Keywords: Randomized; double-blind; placebo-controlled; 5-way crossover; single oral administrations of PF 05212377; scopolamine induced deficits in healthy subjects
Divalproex Sodium in the Treatment of PTSD (Post-Traumatic Stress Disorder)
Condition: PTSD
MeSH terms: Stress Disorders, Post-Traumatic
Study type: Interventional
Phase: Phase 3

Summary: 
      The purposes of this study are:

        -  To study the efficacy of divalproex in the treatment of PTSD;

        -  To study the plasma GABA (gamma aminobutyric acid) levels before and after treatment
           with divalproex in PTSD.
    

Detailed description: 
      Objective: To study the efficacy of divalproex in the treatment of PTSD. Research Design:
      This is an 8-week randomized, double-blind, placebo-controlled treatment trial of divalproex.

      Methodology: After signing an informed consent and meeting all inclusion/exclusion criteria,
      the patient is randomized to either divalproex or placebo for an 8-week duration. During the
      study a pharmacist maintains the randomization log and administers the placebo or divalproex
      (500 mg/capsule) in look-a-like tablets. Patients' symptoms, side effects and compliance are
      assessed bi-weekly. Based on symptomology and occurrence of side effects, the investigator
      increases the medication in 500 mg (one tablet) increments every four days, as tolerated,
      until a maximum therapeutic benefit is achieved, not to exceed 3000 mg/day (6 capsules). The
      dosing is twice daily, with the higher dose at bedtime. Compliance is assessed by bi-weekly
      pill count and blinded valproic acid levels at week 4 and week 8. Patients are given
      supportive clinical management during the clinic visits. An investigator is available by
      telephone 24 hrs a day in case of emergency. Patients may be seen more often if needed.
      Efficacy will be measured by the following assessment scales: MADRS (Montgomery-Asberg
      Depression Rating Scale), Ham-A (Hamilton Anxiety Scale), CGI-s (Clinical Global
      Impressions-Severity of Illness Scale), CGI-I (Clinical Global Impressions-Improvement
      Scale), GAF (Global Assessment of Functioning), CAPS (Clinician-Administered PTSD Scale),
      TOP-8 (Treatment Outcome PTSD Rating Scale), and DTS (Davidson Trauma Scale). Results of this
      study will be used to evaluate the efficacy of divalproex in the treatment of PTSD.

      Significance: Divalproex has shown promise in treating PTSD in open label trials. This study
      is the next step in proving divalproex's efficacy in the treatment of PTSD.
    

Intervention name(s): Divalproex; placebo
Intervention type(s): Drug; Other
Intervention description(s): anticonvulsant; mood stabilizer; Look-a-like placebo
Intervention MeSH terms: Valproic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: anticonvulsant; anxiety; divalproex; PTSD
Propofol-butorphanol Anesthesia During Uterine Curettage
Condition: Abortion; Curettage
Study type: Interventional
Phase: Phase 4

Summary: 
      Uterine curettage is usually performed under the anesthesia of propofol-fentanyl or
      para-cervical block,of which generally has significant incidence of respiratory depression
      which increases the demand on intraoperative monitoring, or has unavoidable insufficient
      blockade which results in intraoperative suffering of pain. Butorphanol is an analgesic with
      combined effects on mu and kappa opioid receptors leading to a role as analgesia and
      sedation. The investigators hypothesized that combined propofol with butorphanol during
      uterine curettage would produce optimal effectiveness of these two drugs by adding sedative
      and analgesic effects together. In addition, it would decrease the intraoperative consumption
      of propofol without increase the incidence of side effects. Furthermore, such combination
      would alleviate postoperative pain.
    


Intervention name(s): Fentanyl Citrate; Butorphanol Tartrate
Intervention type(s): Drug; Drug
Intervention description(s): Combined anesthesia with propofol (2-2.5mg/kg) and fentanyl (5 μg); Combined anesthesia with propofol (2-2.5 mg/kg) and butorphanol (1mg)
Other intervention name(s): Actiq®; Fentora TM; Duragesic®; Torbugesic®; Torbutrol®
Intervention MeSH terms: Fentanyl; Butorphanol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Opioids; General anesthesia
QT Interval in Patients With Pacemaker Dependency
Condition: High Degree AV-block; Left Bundle Branch Block
MeSH terms: Bundle-Branch Block
Study type: Observational

Summary: 
      The aim of this study is to examine a correction term for an adapted QT interval during
      ventricular pacing (right, left and biventricular pacing) to obtain valid formulae correcting
      for the QT intervals in various pacing conditions.
    

Detailed description: 
      This investigation aims at determining a possibility to assess the usefulness of various
      formulae that correct for the different effects of various pacing modes on the QT interval.
      More specifically, the hypothesis will be tested that applying adequate correction will
      preserve the predictive power of the QT-interval regarding proarrhythmia in various cardiac
      pathologies and therapies.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The study will enroll 180 patients after an implantation of cardioverter/defibrillator or
        pacemaker based on a standard guideline indication. The point of enrolment for all patients
        is the time at which the patient signs and dates the ICF during the hospital stay in the
        context of implantation.
      
Biospecimen description: 
      No biospecimen are necessary for the study and this issue is irrelevant.
    
Keywords: pacemaker; ICD / CRTD; corrected QT-interval
Comprehensive Magnetic Resonance of Peripheral Arterial Disease
Condition: Peripheral Artery Disease
MeSH terms: Peripheral Arterial Disease; Peripheral Vascular Diseases
Study type: Interventional

Summary: 
      The purpose of this study is to develop new ways of imaging fatty blockages in the leg
      arteries to improve upon techniques used now and to develop new ways of understanding how new
      treatments may affect the disease.
    


Intervention name(s): Simvastatin; Ezetimibe; Simvastatin/Ezetimibe
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 40mg each night; 10mg daily; 40mg/10mg each night
Other intervention name(s): Zocor; Zetia; Vytorin
Intervention MeSH terms: Simvastatin; Ezetimibe
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: PAD
Effectiveness and Safety of Pharmacopunture Therapy for Chronic Low Back Pain: A Pragmatic Randomized Controlled Trial
Condition: Chronic Low-back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      This is a multi-center, 2-arm parallel pragmatic randomized controlled trial that will
      compare pharmacopuncture therapy with physical therapy for chronic low back pain.
    

Detailed description: 
      This is a multi-center, 2-arm parallel pragmatic randomized controlled trial that will
      compare pharmacopuncture therapy with physical therapy for chronic low back pain.
      Participants who voluntarily signed informed consent form and eligible for the study were
      randomly assigned in a 1:1 ratio (50:50) for pharmacopuncture therapy group and physical
      therapy group. Participants of each group will receive total 5 weeks of intervention. This is
      a pragmatic randomized controlled trial, so physicians will have medical decision making
      according to each participant's conditions and choose the specific type and volume of
      pharmacopuncture and physical therapy.
    

Intervention name(s): pharmacopuncture therapy; physical therapy
Intervention type(s): Procedure; Procedure
Intervention description(s): The procedure will be implemented to participants twice a week for total 5 weeks. The specific prescription including type and dosage will be determined according to the physician's choice, and information will be recorded in the case report form retrospectively.; The procedure will be implemented to participants twice a week for total 5 weeks. The specific prescription including type and body part will be determined according to the physician's choice, and information will be recorded in the case report form retrospectively.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Measurement Skin Temperature During Pulsed Laser Exposure
Condition: Port-Wine Stain
MeSH terms: Hemangioma, Capillary; Port-Wine Stain
Study type: Interventional
Phase: Phase 2

Summary: 
      Lasers are the treatment modality of choice for Port Wine Stain birthmarks.The epidermis is
      not totally spared due to partial absorption of energy therein by melanin that presents an
      optical barrier through which the light must pass to reach the underlying blood vessels.
      Absorption of laser energy by melanin causes localized heating in the epidermis, which may,
      if not controlled, produce permanent complications such as hypertrophic scarring or
      dyspigmentation.
    

Detailed description: 
      The researchers want to establish a correlation between non-invasive skin temperature
      measurements and the minimum laser energy during skin laser treatment using cryogen spray
      cooling.

      This study would eliminate the need for test pulses to estimate the safe and acceptable
      radiant exposure prior to laser treatment.
    

Intervention name(s): cooling spray during laser treatment
Intervention type(s): Procedure
Intervention description(s): skin temperature measurement
Other intervention name(s): laser treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Stopping Postpartum Vitamin A Supplementation: Missing Concealed Benefit
Condition: Vitamin A Deficiency
MeSH terms: Night Blindness; Vitamin A Deficiency
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      The purpose of this study is to evaluate the effect of post-partum maternal vitamin A
      supplementation on breast milk bioactive compounds and immune status, growth and morbidity of
      children in the first four months of life.
    

Detailed description: 
      The effect will be assessed by the milk and blood.
    

Intervention name(s): Vitamin A (<3-day postpartum); Vitamin A (6 wk postpartum); Vitamin A (<3-day and 6 wk postpartum); Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Single dose 200,000 IU vitamin A supplementation at <3-day and placebo supplementation at 6-wk postpartum.; Placebo supplementation at <3-day and single dose 200,000 IU vitamin A supplementation at 6-wk postpartum.; 200,000 IU vitamin A supplementation, both at <3-day and 6-wk postpartum; Placebo supplementation, both at <3-day and 6-wk postpartum.
Intervention MeSH terms: Vitamins; Vitamin A; Retinol palmitate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Vitamin A; Breast milk; Postpartum vitamin A supplementation; Infant vaccine response
Antibacterial Effect of Chlorhexidine Added to the Preventive Protocol in Adolescent Special Needs
Condition: Caries
Study type: Interventional
Phase: Early Phase 1

Summary: 
      This study ia conducted to know the antibacterial effect of chlorhexidine on the mouth flora
      speciallly in adolescent special needs who can't hold the tooth brush properly
    

Detailed description: 
      This study ia conducted to know the antibacterial effect of chlorhexidine on the mouth flora
      speciallly in adolescent special needs who can't hold the tooth brush properly cause those
      have alot of problems concerning the accumulagio. Of plaque and so increased bacteria
    

Intervention name(s): Chlorhexidine varnish added to the preventive protocol; Preventive protocol
Intervention type(s): Drug; Behavioral
Intervention description(s): Antibacterial agent varnish added to the preventive protocol; Preventive protocol
Other intervention name(s): Varnish; Caries preventive protocol
Intervention MeSH terms: Chlorhexidine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Prevention
The Effect of Different Bed-Head Angles on the Haemodynamic Parameters of Intensive Care Patients Lying in the Supine Position
Condition: Thyroidectomy; Colon Surgery; Cholecystectomy; Inguinal Hernia
MeSH terms: Hernia, Inguinal
Study type: Interventional

Summary: 
      Aim: The aim of this study was to examine the effect of different bed-head angles given to
      patients lying in the supine position in an intensive care unit on the haemodynamic
      parameters of central venous pressure, systolic and diastolic blood pressure, heart rate,
      breathing rate and peripheral oxygen saturation.

      Methods: The study was conducted with 50 intensive care patients aged 18 and over in a
      general surgery intensive care unit in Turkey. With each patient in the supine position, the
      bed-head was raised to an angle of 0, 20, 30 and 45 degrees without a pillow, and the
      haemodynamic parameters of central venous pressure, systolic and diastolic blood pressure,
      heart rate, breathing rate and peripheral oxygen saturation were recorded after 0 and 10
      minutes.
    

Detailed description: 
      Aim: The aim of this study was to examine the effect of different bed-head angles given to
      patients lying in the supine position in an intensive care unit on the haemodynamic
      parameters of central venous pressure, systolic and diastolic blood pressure, heart rate,
      breathing rate and peripheral oxygen saturation.

      Design: This was a non-randomised quasi-experimental repeated measures study. Settings: The
      study was conducted with 50 intensive care patients aged 18 and over in a general surgery
      intensive care unit in Turkey.

      Methods: With each patient in the supine position, the bed-head was raised to an angle of 0,
      20, 30 and 45 degrees without a pillow, and the haemodynamic parameters of central venous
      pressure, systolic and diastolic blood pressure, heart rate, breathing rate and peripheral
      oxygen saturation were recorded after 0 and 10 minutes. The data obtained was evaluated using
      the Mann-Whitney test, the Kruskal Wallis test and the Bonferroni test.
    

Intervention name(s): the bed-head was raised to an angle of 0, 20, 30 and 45 degrees
Intervention type(s): Other
Intervention description(s): With each patient in the supine position, the bed-head was raised to an angle of 0, 20, 30 and 45 degrees without a pillow, and the haemodynamic parameters of central venous pressure, systolic and diastolic blood pressure, heart rate, breathing rate and peripheral oxygen saturation were recorded after 0 and 10 minutes.
Other intervention name(s): haemodynamic parameters were recorded
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Intensive care units; haemodynamic parameters; central venous pressure; supine position; bed-head angle