Relationship Between Right Atrial Volume Index, Functional Capacity and Inflammatory Biomarkers in Patients With COPD.
Condition: COPD; Right Heart Failure
MeSH terms: Pulmonary Disease, Chronic Obstructive
Study type: Observational

Summary: 
      Right ventricular (RV) dysfunction is associated with increased morbidity and mortality in
      patients with chronic obstructive pulmonary disease (COPD). Assessment of RV function by
      echocardiography is challenging. Easy visualization of the right atrium (RA) by
      echocardiography , allows quantitative, highly reproducible assessment of RA volume. The aim
      of the present study is to evaluate the relationship between the right atrial volume index
      (RAVI) and functional capacity in patients with COPD , quantified by the COPD assessment test
      (CAT) questionnaire as an early predictor of right heart affection.
    

Detailed description: 
      1. Approval will be obtained from Research Ethics Committee of Faculty of Pharmacy,
           Damanhour University.

        2. All participants agreed to take part in this clinical study and provide informed
           consent.

        3. Patients who were selected from patients visited Chest Department or attending Chest
           outpatient clinic of Tanta University Hospitals, Echocardiography was done in the
           Cardiology Department..

        4. Complete physical and laboratory assessment will be done for all patients.

        5. Serum samples will be collected for measuring the biomarkers.

        6. 150 patients with COPD and preserved left ventricular systolic function, ejection
           fraction (LVEF) > 55% will enrolled. The RA volume calculated by biplane area length
           method using four chamber view twice and indexed to body surface area (RAVI). Assessment
           of RV systolic function was done using tricuspid annular plane systolic excursion
           (TAPSE), and peak systolic velocity (S'tri) using tissue Doppler imaging at the
           tricuspid annulus. The functional capacity was assessed by the COPD assessment test
           (CAT) questionnaire.

        7. For each participant, blood samples were obtained and levels of adiponectin, IL-1B,
           high-sensitivity C-reactive protein and Neopterin will be determined in all studied
           subjects.

        8. Statistical tests appropriate to the study design will be conducted to evaluate the
           significance of the results.

        9. Results, conclusion, discussion and recommendations will be given.
    

Intervention name(s): ECHO
Intervention type(s): Diagnostic Test
Intervention description(s): Conventional routine tests and ECHO will be assessed. Biomarkers will be measured using ELISA The functional capacity was assessed by the COPD assessment test (CAT) questionnaire.
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        All COPD patients participate in this study, were diagnosed on clinical based data and
        confirmed by spirometry findings according to the diagnostic criteria of the Global
        Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines.

        This study was carried out on COPD patients who were selected from patients visited Chest
        Department or attending Chest outpatient clinic of Tanta University Hospitals,
        Echocardiography was done in the Cardiology Department.
      
Keywords: Chronic obstructive lung disease.; Right atrial volume index.; Functional capacity.; Adiponectin.; Hs-CRP.; IL1b.; Neoptrin.