bioihbjkbjnl/mcl2 huggingface dataset:
Vascular Endothelial Growth Factor Levels at Hysteroscopic Biopsies Which Taken From Recurrent Pregnancy Loss
Condition: Recurrent Pregnancy Loss Without Current Pregnancy
MeSH terms: Abortion, Spontaneous; Fetal Death; Abortion, Habitual; Recurrence
Study type: Observational

Summary: 
      The aim of this study is determine vascular endothelial growth factor levels and
      angiogenesis/vascularity from hysteroscopic endometrial biopsies which taken from patients
      who has Recurrent Pregnancy Loss.The endometrial vascular endothelial growth factor levels
      will be measured by immunohistochemical staining methods due to office hysteroscopic
      endometrial biopsy after the menstruation at follicular phase of menstrual cycle.
    

Detailed description: 
      This study is a prospective,observational,single-center study.Ethical approval was obtained
      from the Institutional Review Board.This study will be completed 30 patients with Habitual
      Abortus.

      Endometrial vascular endothelial growth factor levels will be measured using Flk-1 / Kinase
      Domain Receptor / Vascular endothelial growth factor receptor-2, Ab-1 (Rabbit PAb), Vascular
      Endothelial Growth Factor (VEGF) Ab-7 (VG1), Cluster of Differentiation 34 (Endothelial Cell
      Marker) Ab-1 (QBEnd/10), Vascular endothelial growth factor receptor-1 (N-term) (FLT1)
      antibody kits. All assays will be performed according to the manufacturer's instructions.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        The patients with Recurrent Pregnancy Loss
      
Keywords: Vascular endothelial growth factor, Recurrent Pregnancy Loss
A Cognitive Behavioral And Structural HIV Prevention Intervention for Young Ugandan Sex Workers
Condition: Sexually Transmitted Infection
MeSH terms: Sexually Transmitted Diseases
Study type: Interventional

Summary: 
      This study develops and tests a behavioural and structural intervention to prevent
      unprotected sex among young female sex workers. Half the participants will receive the
      intervention and half will receive the standard of care.
    


Intervention name(s): ZETRA cognitive behavioral structural
Intervention type(s): Behavioral
Intervention description(s): ZETRA cognitive behavioral structural
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
To Investigate PK and PD of CJ-12420, Clarithromycin, Amoxicillin After Multiple Dose Administration
Condition: Drug Interaction; Pharmacokinetic; Pharmacodynamic
Study type: Interventional
Phase: Phase 1

Summary: 
      Cohort 1

      To evaluate the pharmacokinetic interactions of CJ-12420 after multiple oral doses of
      CJ-12420 given alone or in combination with amoxicillin/clarithromycin in healthy subjects.

      Cohort 2

      To evaluate the pharmacodynamic profiles of CJ-12420 after multiple oral doses of CJ-12420 in
      combination with amoxicillin/clarithromycin in healthy subjects as compared to an active
      control group, i.e., pantoprazole in combination with amoxicillin/clarithromycin.
    

Detailed description: 
      To evaluate the pharmacokinetic the drug-drug interaction of CJ-12420 and
      amoxicillin/clarithromycin and investigate the pharmacodynamic of co-administration of
      CJ-12420 and amoxicillin and clarithromycin.
    

Intervention name(s): CLR 500mg; CJ-12420 100mg; CJ-12420 50mg; AMX 1g; Pantoprazole 40mg
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): Cohort 1: bid for 5 days Cohort 2: bid for 7 days; Cohort 1: bid for 5 days Cohort 2: bid for 7 days; Cohort 2: bid for 7 days; Cohort 1: bid for 5 days Cohort 2: bid for 7 days; Cohort 2: bid for 7 days
Other intervention name(s): Clarithromycin 500mg; Amoxicillin 1g
Intervention MeSH terms: Amoxicillin; Clarithromycin; Pantoprazole
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
A Randomized, Double-blind, Placebo-controlled Evaluation of Increasing Doses of Weekly Tafenoquine for Chemosuppression of Plasmodium Falciparum
Condition: Malaria
MeSH terms: Malaria
Study type: Interventional
Phase: Phase 2

Summary: 
      This was a randomised, double-blind, placebo-controlled study to compare the efficacy of a
      range four weekly doses of tafenoquine, and weekly mefloquine, with placebo as
      chemosuppression of P. falciparum malaria. Medications and placebo were matched and a
      double-dummy technique enabled blinding of tafenoquine versus mefloquine.
    


Intervention name(s): Placebo; Tafenoquine 25mg; Tafenoquine 50mg; Tafenoquine 100 mg; Tafenoquine 200 mg; Mefloquine 250 mg
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Placebo; Tafenoquine 25mg; Tafenoquine 50mg; Tafenoquine 100 mg; Tafenoquine 200 mg; Mefloquine 250 mg
Intervention MeSH terms: Mefloquine; Tafenoquine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection
Condition: Smallpox
MeSH terms: HIV Infections; Smallpox
Study type: Interventional
Phase: Phase 2

Summary: 
      The main purpose of this clinical trial is to generate additional safety data in a highly
      immunocompromised population. HIV-infected persons are considered excellent candidates to
      represent the highly immunocompromised population for enrolment in this trial. Additionally,
      the immune system's response (protection against smallpox as measured by the amount of
      antibodies produced) following injections of MVA-BN® smallpox vaccine will be evaluated. All
      participants in this trial will be randomly and evenly assigned to one of three groups to
      receive two, three or four injections. Group 1 will receive the standard regime consisting of
      one dose at each vaccination time point, Group 2 will receive two doses at each vaccination
      time point and Group 3 will receive a booster vaccination 12 weeks after the standard
      vaccination schedule with MVA-BN® smallpox vaccine. Participation in the trial is scheduled
      to last up to 75 weeks.
    


Intervention name(s): IMVAMUNE®
Intervention type(s): Biological
Intervention description(s): 0.5 ml Modified Vaccinia Ankara Strain - Bavarian Nordic (MVA-BN®) smallpox vaccine containing at least 1 x 10E8 TCID50 per ml
Other intervention name(s): IMVANEX®; MVA-BN® smallpox vaccine
Intervention MeSH terms: Smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordic
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
The Role of the Endocannabinoid System in Sweet Taste Intensity and Liking
Condition: Sensory Science
Study type: Interventional

Summary: 
      The endocannabinoid (eCB) system, a neurochemical signalling system consisting of
      CB-receptors and their endogenous ligands, has been found to be involved in food intake of
      sweet and palatable foods. Activation of the eCB system increases food intake and vice versa.
      The mechanism behind this effect is still unknown and the current study aims at clarifying
      why sweet food intake increases. It is hypothesized that sweet taste intensity increases and
      that sweet taste is experienced as more pleasant.
    


Intervention name(s): tetrahydrocannabinol; cannabidiol; Placebo
Intervention type(s): Drug; Drug; Drug
Other intervention name(s): delta-9-tetrahydrocannabinol; THC; CBD
Intervention MeSH terms: Dronabinol; Cannabidiol
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
An Open-Label Study in HIV+ Patients to Determine the Effects of Nevirapine (Viramune) on the Pharmacokinetics of Clarithromycin and Activity of Cytochrome 3A4.
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      To evaluate the potential pharmacokinetic interaction between nevirapine and clarithromycin,
      and to determine the effects of nevirapine on cytochrome P450 3A4 (CYP3A4) activity in vivo.
    

Detailed description: 
      The study is conducted in two separate groups. Patients in Group I receive clarithromycin
      orally for 32 days and nevirapine orally for 28 days.

      Patients in Group II receive erythromycin intravenously on days 0, 14, 28, and 43 and
      nevirapine orally for 28 days.
    

Intervention name(s): Erythromycin; Nevirapine; Clarithromycin
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: Clarithromycin; Erythromycin; Erythromycin Estolate; Erythromycin Ethylsuccinate; Erythromycin stearate; Nevirapine
Intervention model: Parallel Assignment
Primary purpose: Treatment
Keywords: Antibiotics, Macrolide; Clarithromycin; Nevirapine; Reverse Transcriptase Inhibitors; Cytochrome P-450; Anti-HIV Agents
Effect of Mulligan Snag and Diaphragmatic Release on Thoracic Kyphosis
Condition: Postural Kyphosis, Cervicothoracic Region
MeSH terms: Kyphosis
Study type: Interventional

Summary: 
      the aim of this study is to investigate the efficacy of mulligan snag mobilisation and
      diaphragmatic release on upper crossed syndrome
    

Detailed description: 
      Acquired postural disorders can be a consequence, to a large extent, of contemporary living
      and working conditions. Some of the most typical factors include continuous use of mobile
      phones and computers, working in sedentary jobs. Prolonged incorrect posture and reduced
      physical activity present a dis-balance in the musculature . It can also lead to vision
      issues, as well as headaches, musculoskeletal issues, and pain, as well as a multitude of
      other symptoms.

      Upon the available research studies, there is not study conducted to investigate the effect
      of mulligan SNAG mobilization and diaphragmatic release in upper crossed syndrome patients
      this trial has four groups; one will receive diaphragmatic release + conventional, the second
      will receive mulligan SNAG mobilization, and conventional, the third will receive mulligan
      SNAG mobilization+diaphragmatic release+conventional, the fourth subjects will receive
      conventional
    

Intervention name(s): mulligan snag mobilization and diaphragmatic release
Intervention type(s): Other
Intervention description(s): The patients will be in the supine position. The therapist makes manual contact bilaterally under the costal cartilages of the lower ribs (7th to 10th ). During the patient's inspiration, the therapist will gently pull the points of hand contacts toward the head and slightly laterally. During exhalation, the therapist will deepen hand contact toward the inner coastal margins.
mulligan snag, Apply a passive intervertebral movement in a superior anterior direction along the facet plane. While maintaining this "glide" as the patient actively moves in any range of physiological movement
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: EFFECT OF MULLIGAN SNAG MOBILISATION AND DIAPHRAGMATIC RELEASE
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Dosage Effects of Folic Acid on Blood Folates of Honduran Women
Condition: Spina Bifida and Anencephaly
MeSH terms: Spinal Dysraphism; Anencephaly
Study type: Interventional

Summary: 
      CDC staff at the National Center on Birth Defects and Developmental Disabilities have been
      working closely with a Honduras-based organization, Project Healthy Children (PNS) and the
      Ministry of Health, on a folic acid supplementation study among female maquila workers.
      Participants are divided into two groups. One group receives a 1.0 milligram pill daily while
      the other group receives a 5.0 milligram pill weekly. The aim of this study is to assess
      serum blood folate levels measured at baseline, midpoint, and endpoint of the study.
      Hypothesis: Folic acid (5mg)given once weekly is as effective as folic acid (1mg)given daily
      in raising blood folate levels.
    


Intervention name(s): folic acid
Intervention type(s): Drug
Intervention MeSH terms: Folic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Prevention
Women With Chest Pain and no Significant Coronary Artery Stenosis; A Study on Microvascular Resistance
Condition: Angina Pectoris
MeSH terms: Angina Pectoris; Chest Pain
Study type: Interventional
Phase: Phase 4

Summary: 
      Female patients presenting with persistent chest pain despite no obstructive coronary artery
      disease have impaired prognosis. Stress tests are often positive or inconclusive. As much as
      20% of women with chest pain and minimal angiographic CAD have evidence of myocardial
      ischemia, suggesting impaired coronary microcirculation. The index of microvascular
      resistance (IMR) is a method for indirectly investigating microvascular function in the
      cardiac catheterization laboratory.

      66 female patients, age 30-70 years, with chest pain and "normal" or near normal coronary
      angiograms will be included. After coronary physiologic evaluation, patients will be
      randomized in a double blind study to rosuvastatin 20 mg/day or matching placebo tablets for
      altogether 6 months.

      The investigators hypothesize that:

        1. A substantial number of women with chest pain and normal or minimal pathology on
           angiograms have microvascular dysfunction defined by a raised IMR.

        2. Statins, based on its pleiotropic action will improve endothelial function and thereby
           IMR.
    


Intervention name(s): Rosuvastatin; Placebo.
Intervention type(s): Drug; Drug
Intervention description(s): Rosuvastatin 20 mg once daily vs placebo for 6 months; Placebo once daily vs rosuvastatin for 6 months
Intervention MeSH terms: Rosuvastatin Calcium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Fat Based Enteral Nutrition for Blood Glucose Control in ICU
Condition: Hyperglycemia
MeSH terms: Hyperglycemia
Study type: Interventional

Summary: 
      In this randomized, double-blind clinical trial, eligible hospitalized ICU patients with EN
      will be included. Patients will be divided into two groups. The control group with the
      standard EN and intervention group with high fat EN. 50% of the total fat will be provided by
      olive oil. Nutritional intake record form will be completed and daily calorie intake will be
      calculated. High fat EN feeding will be offered for 15 consecutive days maximally. At the end
      of the study mean blood glucose, duration of hospitalization and rate of infection will be
      compared in two groups.
    

Detailed description: 
      In this randomized, double-blind clinical trial, 88 eligible hospitalized ICU patients with
      EN will be included. Written consent form will be completed. Physical examination will be
      done by specialist and nutritional care process will be offered by an RD. Demographic,
      laboratory and nutritional data will be extracted and entered in prepared form. Venous blood
      samples will be taken and laboratory values will be measured and recorded at specified times.
      Patients will be divided into two groups. The control group with the standard EN (Protein;
      20% carbohydrate; 50% and fat; 30% from total calories) and intervention group with high fat
      EN (Protein; 20% carbohydrate; 35% and fat; 45% from total calories). 50% of the total fat
      will be provided by olive oil. Any feeding rout such as naso - gastric , Percutaneous
      endoscopic gastrostomy (PEG ) or Percutaneous endoscopic jejunostomy (PEJ) with Intermittent
      feeding protocol will be accepted feeding method . Nutritional intake record form will be
      completed and daily calorie intake will be calculated. High fat EN feeding will be offered
      for 15 consecutive days maximally
    

Intervention name(s): High Fat Enteral Nutrition
Intervention type(s): Other
Intervention description(s): Diet in high fat group will be 20% from protein, 45% from fat and 35% from carbohydrate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Critically ill; Diet; Blood glucose
Developing a Web-based Shared Decision-making Tool for Fertility Preservation
Condition: Breast Neoplasm Female
MeSH terms: Breast Neoplasms
Study type: Interventional

Summary: 
      The objective of this study was to develop a web-based, shared decision-making (SDM) tool for
      helping patients with breast cancer make decisions on fertility preservation.
    

Detailed description: 
      Background: The pregnancy rate after cancer treatment for female survivors is lower than that
      of the general population. Future infertility is a significant concern for patients with
      breast cancer and is associated with a poor quality of life. Reproductive- age patients with
      breast cancer have safe options when choosing the type of fertility preservation method to be
      applied. Better information and support resources aimed at women to support their decision
      making are needed.

      Objective: The objective of this study was to develop a web-based, shared decision-making
      (SDM) tool for helping patients with breast cancer make decisions on fertility preservation.

      Methods: We used the action research cycle of observing, reflecting, planning, and acting to
      develop a web-based SDM tool. The following four phrases were applied: (1) Observe and
      reflect: Collect and analyze the decision-making experiences of patients and health care
      providers; (2) Reflect and plan: Apply the initial results to create a paper design and
      modify the content; (3) Plan and act: Brainstorm about the web pages, and modify the content;
      (4) Act and observe: Evaluate the effectiveness, and refine the website SDM. Interviews,
      group meetings, and constant dialogue were conducted between the various participants at each
      step. The effectiveness was evaluated using the Preparation for Decision-Making (prepDM)
      scale.
    

Intervention name(s): a web-based shared decision-making tool
Intervention type(s): Device
Intervention description(s): Five major parts were developed with the use of the action research approach. The Introduction and Options (parts 1 and 2) describe the severity of the cancer treatment and infertility and the knowledge of fertility preservation, respectively. The SDM tool was designed as a step by step process (part 3) that involves the comparison of options, patient's values and preferences, their knowledge regarding infertility and options, and reaching a collective decision. The Resources (part 4) provide information on the hospitals that provide such services, and the References (part 5) list all the literature cited in the website. The results show the web-based SDM meets both the patients' and health providers' needs and helps reproductive-age patients with breast cancer make decisions on fertility preservation.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: breast cancer; shared decision making; website; action research; fertility preservation
A Study to Evaluate the Pharmacokinetics and Safety Between Single Administration of "BR6002" and Coadministration of "BR6002A" and "BR6002B" Under Fasting Conditions in Healthy Adult Volunteers
Condition: Gastric or Duodenal Ulcers
MeSH terms: Duodenal Ulcer
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this clinical trial is to evaluate the pharmacokinetics and safety between
      single administration of "BR6002" and coadministration of "BR6002A" and "BR6002B" under
      fasting conditions in healthy adult volunteers
    


Intervention name(s): BR6002A; BR6002B; BR6002
Intervention type(s): Drug; Drug; Drug
Intervention description(s): One tablet administered alone; One tablet administered alone; One capsule administered alone
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Efficacy of Hyaluronic Acid and Platelet-rich Plasma Combination in Knee Osteoarthritis
Condition: Knee Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to evaluate the efficacy of intra-articular injections of
      combined hyaluronic acid and platelet-rich plasma in knee degenerative joint disease in
      improving joint function and reducing pain.
    


Intervention name(s): hyaluronic Acid + platelet-rich plasma; hyaluronic acid; platelet-rich plasma
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Intra-articular injections of hyaluronic acid combined with platelet-rich plasma; Intra-articular injections of hyaluronic acid; Intra-articular injections of platelet-rich plasma
Other intervention name(s): Cellular Matrix/A-CP HA Kit; ArthroVisc40; RegenKit-BCT-1
Intervention MeSH terms: Hyaluronic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment