bioihbjkbjnl/mcl2 huggingface dataset:
Interval Versus Continuous Training in Healthy Adults
Condition: Healthy Volunteers
Study type: Interventional

Summary: 
      Aerobic exercise produces increases in cardiorespiratory fitness (CF), which constitute a
      protective factor for cardiovascular disease and all-cause mortality. Therefore, aerobic
      exercise is a key strategy to promoting cardiovascular. There is some evidence that aerobic
      high intensity interval training may lead to greater increases in CF compared with continuous
      moderate-intensity training.

      The main objective of this study is to examine the effects of an aerobic high intensity
      training program versus a continuous moderate intensity training program on CF in men 18 to
      44 years.
    

Detailed description: 
      Forty-four individuals will be randomly assigned to one of two aerobic training programs on a
      treadmill. Both groups will performed three times a week for eight-weeks (on alternate days).
      Half will run 40 minutes of continuous exercise at an intensity between 65-75% of maximum
      heart rate, and the remaining 22 will complete 21.5 minutes of interval exercise at an
      intensity between 90-95% of maximum heart rate, with recoveries between 50-55 % of maximum
      heart rate. After each session both groups will complete eight strength exercises mainly
      including large muscle groups for two sets and 8-12 repetitions at an intensity equivalent to
      60-70% of one repetition maximum (controlled by perceived effort). Rest between sets will be
      kept between 60 and 90 seconds.

      All participants will be evaluated at the start and completion of the intervention for their
      maximal oxygen consumption, blood pressure, waist circumference, BMI, body composition, and
      steps per week.
    

Intervention name(s): Aerobic interval training; Continuous training
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Aerobic Exercise; Oxygen Consumption; Blood Pressure
Availability of Lipids in Almonds in Healthy Individuals
Condition: Obesity; Overweight
MeSH terms: Overweight
Study type: Observational

Summary: 
      Evidence indicates that almond consumption is associated with multiple health benefits.
      However, nuts are commonly excluded from diets on the basis that their high energy content
      may induce weight gain. Evidence from numerous studies show that this is not the case, yet
      the mechanism responsible for the less than predicted effect on weight is unknown. This study
      aimed to examine the effects of increased mastication on lipid bioavailability and satiety
      related peptide released in humans. Its purpose is to provide valuable mechanistic data to
      support the results from previous completed clinical studies.
    

Detailed description: 
      This cross-over study consisted of three study periods of four consecutive days separated by
      at least one week. During each day of the three study periods, participants were required to
      consume 55g of almonds split up into 5 g portions. They were required to chew the almonds 10,
      25, or 40 times before swallowing, depending on the treatment. During each treatment period,
      all participants followed the same procedures over the four days. On day one after an
      overnight fast, participants reported to the laboratory and were presented with 11, 5 gram
      portions of almonds to chew 10, 25, or 40 times, depending on treatment arm. The participant
      remained in the laboratory for 4 hours post-almond consumption for measurements of blood and
      appetite. For the remainder of the 4 days, participants consumed all meals in the laboratory
      and collected all stools passed. On a separate occasion, recovered particle sizes of
      masticated almonds were measured by a mechanical sieving process. Individuals chewed almond
      samples either 10, 25 or 40 times and expectorated them into sieves.
    

Intervention name(s): 10 chews; 25 Chews; 40 Chews
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Participants were required to chew 55g grams of almonds per day for four days in 11, 5 gram portions. Almonds were to be chewed 10 times before swallowing.; Participants were required to chew 55g grams of almonds per day for four days in 11, 5 gram portions. Almonds were to be chewed 25 times before swallowing.; Participants were required to chew 55g grams of almonds per day for four days in 11, 5 gram portions. Almonds were to be chewed 40 times before swallowing.
Other intervention name(s): Almonds; Almonds; Almonds
Observational model: Case-Crossover
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        University and community sample
      
Biospecimen description: 
      Plasma, feces
    
Keywords: Nuts; Lipids; Mastication; Bioaccessibility; Satiety; Hormones; Human
Sleep Quality in CHIMES (MF101)
Condition: Sleep Quality; Menopausal Symptoms
Study type: Interventional
Phase: Phase 2

Summary: 
      Menopausal women often complain of difficulty sleeping and the transition from pre- to
      postmenopausal status is associated with an incresase in self-reported sleep disturbance. Hot
      flashes have been associated with self-reported measures of sleep disturbance and changes in
      sleep pattern as measured by plysomnography, including an increase in stage 4 and a latency
      or shortened time in rapid-eye movement sleep. Although there are some data on the effect of
      hormone replacement therapy on self-reported sleep measures in symptomatic postmenopausal
      women, there are no data on the effect of herbal extracts on subjective or objective measures
      of sleep quality in this population group. Actigraphy, the use of a device to record movement
      generally placed on the wrist, has been used over 20 years to provide objective data
      concerning sleep/wake patterns. The advantage of actigraphy over traditional polysomnography
      is that actigraphy can conveniently record continuously for 24-hours a day for longer periods
      of time.
    

Detailed description: 
      Specific Aims:

        1. To determine the effect of MF101 (a combination of Chinese herbs) compared to placebo on
           change in sleep quality utilizing baseline and follow-up actigraphy obtained from a
           subset of approximately 90 women enrolled in the randomized, double-blind,
           placebo-controlled Chinese Herbs for Menopausal Symptoms (CHIMES) trial.

        2. TO identify the correlates of sleep quality as assessed by actigraphy in women with
           frequent hot flashes. We will evaluate demographic, lifestyle, anthropometric, medical
           and gynecologic history and hormonal factors that may relate to the actigraphic measures
           of sleep quality, including self-reported measures of sleep.
    

Intervention name(s): MF101
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Sleep Quality; Menopausal Symptoms; Actigraph; Bionovo; MF101
A Study of MabThera (Rituximab) in Elderly Patients With Untreated Follicular Non-Hodgkin's Lymphoma (NHL)
Condition: Non-Hodgkin's Lymphoma
MeSH terms: Lymphoma; Lymphoma, Non-Hodgkin
Study type: Interventional
Phase: Phase 3

Summary: 
      This study will evaluate the efficacy and safety of brief induction therapy with a
      chemotherapeutic regimen containing MabThera, followed by either maintenance therapy with
      MabThera or no further therapy. The anticipated time on study treatment is 1-2 years, and the
      target sample size is 100-500 individuals.
    


Intervention name(s): rituximab [Mabthera/Rituxan]
Intervention type(s): Drug
Intervention description(s): Intravenous repeating dose
Intervention MeSH terms: Rituximab
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Evaluation of "Tent-Pole" Grafting Technique for Reconstruction of Mandibular Ridge Vertical Defects
Condition: Jaw Deformity
MeSH terms: Jaw Abnormalities; Congenital Abnormalities
Study type: Interventional

Summary: 
      The aim of this study is to evaluate clinically and radio-graphically the efficiency of
      "Tent- Pole "grafting technique for reconstruction of anterior or posterior mandibular ridge
      defects using synthetic bone graft and Platelet Rich Fibrin (PRF) membrane.
    

Detailed description: 
      Various techniques have been described for the reconstruction of large vertical defects
      before implant placement . In this study we assessed the efficacy of tenting the periosteum
      and soft tissue matrix with titanium screws maintaining a space for the graft material in
      order to augment large vertical defects of mandibular ridge (anterior or posterior region)
      using data from 12 patients . After 6 months we assessed the increase in bone height and
      density.
    

Intervention name(s): Tent Pole Technique
Intervention type(s): Procedure
Intervention description(s): All patients were operated under local or general anaesthesia according to the case and patient tolerability.
The oral cavity was prepared by 0.12% chlorhexidine mouthrinses solution* for thirty seconds.
Full thickness incision down to the bone with blade no.15.
A periosteal elevator was used to perform mucoperiosteal flap.
Gentle elevation of the flap
Fixation of the screws over the alveolar ridge with about 5 mm of the screw threads will be exposed
Bone graft was mixed with the patient blood and placed to cover the screws completely.
PRF membrane was be placed over the grafted sites.
Repositioning of the flap and suturing with 3/0 black silk suture material
Intervention model: Single Group Assignment
Intervention model description: This is a single-arm trial of 12 patients with mandibular large vertical defects treated using synthetic bone graft around titanium screws to tent out the soft tissue matrix.
Masking: None (Open Label)
Primary purpose: Treatment
A Study of the Safety of Risperidone in the Treatment of Children and Adolescents With Conduct and Other Disruptive Behavior Disorders
Condition: Disruptive Behavior Disorder
MeSH terms: Mental Disorders; Problem Behavior; Attention Deficit and Disruptive Behavior Disorders
Study type: Interventional
Phase: Phase 3

Summary: 
      The primary purpose of this study is to document the long-term safety of an oral formulation
      of risperidone in the treatment of children and adolescents with conduct and other disruptive
      behavior disorders. Data on the efficacy of the drug will also be collected. Only patients
      who were enrolled in the previous related study would be eligible to participate.
    

Detailed description: 
      This is an open-label study of an oral formulation of risperidone to be taken daily over 12
      months by children and adolescents with conduct and other disruptive behavior disorders. It
      is an extension of a randomized, double-blind study (RIS-INT-79) comparing risperidone with
      placebo over 6 months in patients who had already shown response to the medication for a
      period of 12 weeks. Efficacy assessments include: the Conduct Problem subscale of the
      Nisonger Child Behavior Rating Form (N-CBRF), a measure of symptoms of conduct and other
      disruptive behavior disorders; Visual Analogue Scale for the most troublesome symptom
      (VAS-MS), a scale ranging from not troublesome to extremely troublesome; Clinical Global
      Impression-Severity of Illness (CGI-Severity), a measure of overall severity of illness;
      Children's Global Assessment Scale (C-GAS), as assessment overall functioning. Safety
      evaluations include incidence of adverse events, physical examinations, laboratory tests
      (biochemistry, hematology, and urinalysis), and electrocardiograms (ECGs). Oral risperidone
      solution (1milligram/milliliter) daily for 1year. For patients weighing at least 50kg, start
      dose is 0.5ml/day. At investigator's discretion, dose may be increased (maximum 1.5ml/d over
      5 days). Patients under 50kg start at 0.25ml/d, increased, if required, to maximum 0.75ml/d.
    

Intervention name(s): risperidone
Intervention type(s): Drug
Intervention MeSH terms: Risperidone
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Disruptive behavior disorder; risperidone; antipsychotropic agents; child; adolescent
Remote Monitoring Use In Cases Of Suspected COVID-19 (Coronavirus)
Condition: Coronavirus
MeSH terms: Coronavirus Infections
Study type: Observational

Summary: 
      The study aims to see if participant deterioration due to suspected coronavirus in a
      designated location (e.g. hotel) can be identified sooner by wearing the sensor. If sick
      patients can be identified early, participants are more likely to have better outcomes; the
      study believes that the sensor can help us do this. The sensor measures heart rate,
      respiratory rate and temperature every 2 minutes and this can be reviewed by the clinical
      team looking after the participants.
    


Intervention name(s): SensiumVitals wearable sensor
Intervention type(s): Device
Intervention description(s): A waterproof, light, wearable sensor measuring vital signs (heart rate, respiratory rate, temperature) continuously.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        -  Returning traveller from a high-risk area into a London airport.

          -  Have mild symptoms indicative of Covid-19

          -  Unable to self-isolate
      
Keywords: coronavirus; remote monitoring; deterioration; escalation
Establishment of the 2H-labeling Protocol at Pennington Biomedical Research Center
Condition: Overweight and Obesity; Exercise
MeSH terms: Overweight
Study type: Observational

Summary: 
      A method has been developed to measure in vivo adipose kinetics and turnover rates, which is
      a substantive departure from previous indirect and in vitro approaches. This technique
      involves drinking deuterium (2H)-labeled water, with an initial ramp-up to increase body
      water 2H enrichment, followed by daily intake to maintain enrichment values. The 2H from the
      heavy water is incorporated into the DNA of the dividing cells, as well as the lipid
      component, providing measures of cell formation, lipid synthesis, and adipose turnover. The
      objective of the proposed study is to enroll women who are overweight (sedentary or
      physically active) in order to collect 2H-enriched adipose tissue specimens that will be
      utilized to establish this innovative 2H-labeling protocol at Pennington Biomedical Research
      Center. This study will also assess adipose kinetics in individuals with different levels of
      physical activity to better understand the association between in vivo adipose cell kinetics,
      physical activity, and metabolic health in humans.
    


Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        12 women who are overweight and are either sedentary or very physically active will be
        enrolled in the study.
      
Biospecimen description: 
      Adipose tissue biopsies from the subcutaneous abdominal and femoral regions will be
      collected.
    
Keywords: Adipose tissue; Adipose turnover; Adipose kinetics; Exercise; Deuterium
Hormones and Social Anxiety Disorder Treatment
Condition: Social Anxiety Disorder
MeSH terms: Anxiety Disorders; Phobia, Social
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether power posing (i.e., holding poses
      associated with dominance and power), compared to submissive posing or rest, prior to
      exposure therapy for social anxiety disorder: 1) leads to a temporary increase in
      testosterone levels and/or 2) facilitates exposure therapy outcomes.
    


Intervention name(s): Cognitive Behavioral Therapy
Intervention type(s): Behavioral
Intervention description(s): Exposure therapy for social anxiety disorder
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Awake Nasal Intubation in Laryngopharyngeal Tumors
Condition: Airway Management
Study type: Interventional

Summary: 
      This study evaluates the efficiency of awake naso-tracheal intubation and patient
      satisfaction when using a small diameter flexible nasolaryngoscope together with topical
      anaesthesia and light sedation with a combination of benzodiazepine and fentanyl. The
      selected patients will have difficult airway access because of obstructing oro- and
      hypo-pharynx tumours.
    

Detailed description: 
      Awake naso-tracheal fiberoptic intubation is an established method of securing a difficult
      airway. The patient's comfort and optimum intubation conditions are paramount for success.
      The study proposes to analyse a series of patients with obstructive pharyngo-laryngeal
      pathology, following the degree of satisfaction, reliability of the procedure and any
      incidents or complications.

      Awake intubation could be the safest way to control difficult airway as the patient maintains
      spontaneous respiration and intact reflexes. Main concerns for the success of this procedure
      should be a good technique, a calm and cooperative patient and good preparation with careful
      topical anaesthesia and appropriate sedation. The tool used in this study will be a flexible
      nasolaryngoscope of 2.9 mm diameter and 300 mm working length which might offer an advantage
      over lengthier fiberscopes in matter of manoeuvrability and patient comfort. Prior intubation
      the patients will have an upper airway fiberscopic exam from nostrils to tracheae with the
      same tool.
    

Intervention name(s): fiberoptic naso-tracheal intubation; Topical anaesthesia; Light sedation
Intervention type(s): Device; Drug; Drug
Intervention description(s): The trachea will be intubated under direct fiberoptic view after a fiberoptic upper airway examination. The flexible nasolaryngoscope will be armed with an intubating tube and passed inside tracheal lumen trough one of the nostrils.; Topical anaesthesia with lidocaine will be provided through nebulisation and instillation. The intubating tube will be lubricated with a gel containing lidocaine.; The patient will be sedated with a combination of midazolam, fentanyl administered intravenously in small boluses until the desired level of sedation is achieved as expressed of The Observer's Assessment of Alertness/Sedation Scale (OAA/S) of 4 or 5.
Intervention MeSH terms: Anesthetics
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: awake intubation; nasal fiberscope; topical anesthesia
Remote Ischemic Conditioning and Platelet Dysfunction
Condition: Platelet Function
MeSH terms: Ischemia
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the effects of remote ischemic conditioning on
      platelet function during off-pump coronary artery bypass surgery.
    

Detailed description: 
      Remote ischemic conditioning (RIC) may affect platelet function. However, little is known
      about effect of RIC on platelet function during off-pump coronary artery bypass surgery. In
      this study investigators are going to perform RIC after anesthesia induction (remote ischemic
      pre-conditioning) and after completion of coronary anastomoses (remote ischemic
      post-conditioning), and compare platelet function parameters with control group.
    

Intervention name(s): Remote ischemic conditioning; Control
Intervention type(s): Procedure; Procedure
Intervention description(s): In the RIC group, RIC is performed before and after coronary anastomoses by 5 minutes limb ischemia and reperfusion with pneumatic cuff up to 200 mmHg repeated by four times.; In the control group, all the procedures will be same with RIC group, except for the fact that the three-way stopcock between the pneumatic cuff and the cuff inflator was opened and therefore the cuff pressure did not increase.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: remote ischemic conditioning; off-pump coronary artery bypass surgery
Music and Perceived Rate of Exertion
Condition: COPD
Study type: Interventional

Summary: 
      The aim of this study was to evaluate the effect of listening to ambient music on the
      perceived exertion rate during pulmonary rehabilitation for chronic obstructive pulmonary
      disease patients.
    


Intervention name(s): Music
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Time Course and Nature of Nutrient Sensing During Fasting in Humans
Condition: Nutrient Sensing During a Prolonged Fast
Study type: Interventional

Summary: 
      Several studies have begun to determine the time course of events sensing energy availability
      in rodents. In contrast, there is not a single study that has examined this in humans to
      date. A better understanding of this energy sensing machinery in humans is of utmost
      importance to give us new insights into developing new therapies for common diseases such as
      obesity, diabetes mellitus, cardiovascular diseases and cancer. In these diseases,
      disturbances in the energy-sensing machinery possibly play a role. To determine the time
      course of energy sensing events in humans, the investigators will measure the concentration
      of various hormones in plasma, and biochemical changes in skeletal muscle at sequential time
      points during starvation in humans. The investigators choose to study the molecular machinery
      in muscle, since muscle is very sensitive to fuel deprivation.
    


Intervention name(s): Prolonged fasting
Intervention type(s): Behavioral
Intervention description(s): 48 hours of fasting
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Set time points during 48 hours of fasting