bioihbjkbjnl/mcl2 huggingface dataset:
The Effects of Virtual Reality Patients With Obstetric Brachial Plexus Injury
Condition: Obstetric Brachial Plexus Injury
MeSH terms: Wounds and Injuries
Study type: Interventional

Summary: 
      Obstetric brachial plexus injury is the flask paralysis of the arm, which emerges from a
      difficult birth. This results from the damage to the nerves from the C5 cervical root to T1.
      Following brachial plexus injury, movement impairment, a decrease in the joint range of
      motion, muscle contractures, motor disorders related to muscle weakness, and the loss of
      functional movements are commonly observed. Many rehabilitation programs for the upper
      extremity aim at developing functional improvement in addition to increasing the active range
      of motion of the related limb in children with Obstetric brachial plexus injury. Obstetric
      brachial plexus injury treatment includes both conservative and surgical interventions. The
      first intervention in all the Obstetric brachial plexus injury cases is conservative. In
      recent years, supporting the treatment with virtual reality exercises in addition to the
      conventional brachial plexus rehabilitation is a method being tested. The use of virtual
      reality treatment in physiotherapy and rehabilitation has substantially increased within the
      last 6-7 years. Virtual reality is a method that enables working with task-based techniques
      by creating stimulating and entertaining environments and especially using children's
      interest and motivation. Nintendo Wii, which is used in the virtual reality treatment, is a
      device that can be controlled wirelessly, consists of a system console, remote control for
      activity control, and a sensor perceiving the change in movements, and a display screen, and
      gives the opportunity to work with the person individually. The aim of this study is to
      investigate the effects of the conventional physiotherapy approach and virtual reality
      applications with Nintendo Wii, applied additionally in this study, on upper extremity
      functions in children with obstetric brachial plexus injury. They can directly be mentioned
      as the effects on muscle strength, normal joint range of motion, and functionality.
    


Intervention name(s): Virtual reality treatment; conventional physiotherapy
Intervention type(s): Other; Other
Intervention description(s): Tennis, boxing, and baseball games of the Wii Sports package sre used for activating the upper extremity functions of the patients. In the tennis game, patients represent people holding rackets.; As the conventional physiotherapy, neuromuscular electrical stimulation and strengthening exercises for the deltoid, infraspinatus, triceps, biceps, supinator, and wrist extensor muscles, and passive, active, active assistive joint Rage of Motion, and stretching exercises for the shoulder, elbow and wrist joints are applied to the patients in the standardized program for the upper extremity in 10 repetitions.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Study of the Safety, Tolerability, Pharmacokinetic Characteristics of PA1010 in Healthy Subjects
Condition: Chronic HBV Infection
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objectives of this study are to evaluate the safety, tolerability and
      pharmacokinetics characteristics of single ascending dose (SAD) of PA1010 tablets in Chinese
      healthy adults and the impact of food and gender on the pharmacokinetics
    

Detailed description: 
      Stage I: Single dose, Single Ascending Dose (SAD)

      This is a randomized, double-blind, placebo-controlled, dose-escalation clinical trial. The
      objective is to evaluate the safety, tolerability and pharmacokinetics characteristics of
      PA1010 tablets in Chinese healthy subjects. There are six dose groups of PA1010 ( 5 mg、10
      mg、20 mg、30 mg、45 mg and 60 mg) proposed to be tested sequentially in this study. A total of
      60 healthy subjects are planned to be enrolled in this study and will be randomly assigned to
      the corresponding dose group in equal proportion, stratified by gender (male vs female). 10
      subjects in each dose group are randomly assigned in a ratio of 4:1 to receive PA1010 tablets
      or placebo. All subjects will be dosed in a single dose, and the dose-related safety,
      tolerability and PK of PA1010 will be evaluated.

      Stage II: Study on the effect of food on Pharmacokinetics

      This is a single center, randomized, open, two group crossover, self-control clinical trial.
      A total of 20 subjects are planned to be enrolled in this study, and will be randomly
      assigned to a dosing order (i.e. fasting administration followed by high-fat meal
      administration, or high-fat meal administration followed by fasting administration) in a
      ratio of 1:1. Subjects will be dosed 10 mg PA1010 tablets in a single dose, and the
      food-related PK of PA1010 will be evaluated.
    

Intervention name(s): PA1010
Intervention type(s): Drug
Intervention description(s): Placebo as control
Allocation: Randomized
Intervention model: Sequential Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Interventional Management of Stroke (IMS) II Study
Condition: Stroke
MeSH terms: Stroke
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to examine the effects of delivering intra-arterial recombinant
      tissue plasminogen activator (rt-PA) and ultrasound to the site of the blood clot blocking
      blood flow to the brain of stroke patients.
    

Detailed description: 
      The overall goal of Interventional Management of Stroke (IMS II) study is to refine
      thrombolytic therapy for patients with acute ischemic stroke who can be treated within three
      hours of stroke onset.

      This multi-center, non-randomized pilot study will provide preliminary data about the
      benefits and risks of combined intravenous (IV) and intra-arterial (IA) recombinant tissue
      plasminogen activator (rtPA) and low-intensity ultrasound energy in ischemic stroke patients
      with baseline NIHSSS >/= 10 in whom intravenous treatment can be started within three hours
      of stroke onset. rt-PA is a thrombolytic, clot-dissolving drug.

      The primary objectives for the study are to obtain reliable estimates of the effectiveness
      and safety of a treatment approach combining IV/IA rt-PA and ultrasound for stroke patients;
      and to determine if the estimated effectiveness of combined IV/IA rt-PA at 3 months-as
      compared to the 3 month outcome of placebo-treated patients in the NINDS rt-PA Stroke
      Trial-warrants proceeding to a large, phase III randomized trial.
    

Intervention name(s): Recombinant tissue plasminogen activator; Low-intensity ultrasound
Intervention type(s): Drug; Procedure
Intervention description(s): Low-dose IV rt-PA (0.6 mg/kg) followed by delivery of additional IA rt-PA (up to 22 mg).; Delivery of additional IA rt-PA (up to 22 mg) in the setting of low-energy ultrasound via the EKOS microinfusion catheter at the site of IA occlusion in acute ischemic stroke patients with large strokes (NIHSS >/= 10) treated within 3 hours of symptoms onset.
Intervention MeSH terms: Plasminogen; Tissue Plasminogen Activator
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: acute ischemic stroke; stroke; rt-PA; thrombolytic; recombinant tissue plasminogen activator
Postoperative Vitamin Supplementation in Morbidly Obese Patient (VITAAL Study)
Condition: Obesity; Vitamin Deficiency
MeSH terms: Avitaminosis
Study type: Interventional
Phase: Phase 4

Summary: 
      This study is a double blind randomized controlled trial.
    

Detailed description: 
      Based on evidence-based literature on vitamins and minerals, there is a cooperation of a
      manufacturer multivitamin specifically designed for patients with a gastric band and
      Roux-en-Y gastric bypass (RYGB). These preparations are the proportions adjusted so that the
      risk of shortages should decrease and on the other hand, excessive levels of nutrients should
      be avoided. Main objective of this study is to examine whether these new supplements in
      particular the number of deficiencies in iron, vitamin B12 and vitamin D can be reduced.
    

Intervention name(s): Fit For me; Davitamon
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention MeSH terms: Tocopherols
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Vitamine; mineral; obese patients; Vitamine en mineral shortage in obese patients
Clinical Observation of Titration Induction and Convention Induction of Propofol
Condition: Propofol Overdose of Undetermined Intent
MeSH terms: Drug Overdose
Study type: Interventional

Summary: 
      As we know propofol is popular use in the anesthesia induction with kilogram and it always
      cause hypotension. So we compare haemodynamic changes and drug consumption between propofol
      titrated administration and traditional administration for anesthesia induction.
    

Detailed description: 
      GroupⅠreceived propofol 2 mg/kg intravenously by Fresenius pump at the speed of 250 mg/min,
      GroupⅡreceived propofol intravenously by Fresenius pump at the speed of 1 mg/kg/min, and
      observe's assessment of alertness and sedation(OAA/S) scale of the patients was titrated to
      1, then changed to a maintenance dose
    

Intervention name(s): titration induction to propofol
Intervention type(s): Procedure
Intervention description(s): propofol intravenously by Fresenius pump at the speed of 1 mg•kg-1•min-1, and OAA/S scale of the patients was titrated to 1
Intervention MeSH terms: Propofol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Electronic Cigarette Use in Young Adult Men and Women
Condition: Cigarette Smoking; Tobacco Use
Study type: Interventional

Summary: 
      This one-year pilot study of 30 non-treatment seeking young adult e-cigarette/combustible
      tobacco product dual users (15 males/15 females) will use smartphone-based ecological
      momentary assessment (EMA) to gather real-time data of e-cigarette and combustible tobacco
      product behaviors during a 1-week cigarette/e-cigarette dual use period .(1) Participants
      will respond to daily random prompts assessing in-the-moment use of e-cigarettes/cigarettes
      and the subjective factors (ratings of satisfaction and withdrawal) and contextual factors
      (location, activity, social cues) associated with each episode of use. Participants will also
      complete daily electronic diaries to document e-cigarette use episodes/day, and satisfaction
      with the e-cigarette experience during the study.
    


Intervention name(s): Survey Arm
Intervention type(s): Behavioral
Intervention description(s): Contingency Management for completion of surveys and evidence of tobacco use status
Intervention model: Single Group Assignment
Intervention model description: 30 non-treatment seeking young adult e-cigarette/cigarette dual users (15 males/15 females) will participate in a contingency-management reinforced 1 week observation period
Masking: None (Open Label)
Primary purpose: Treatment
Cognition and Emotion in the SII and IBD
Condition: Irritable Bowel Syndrome; Inflammatory Bowel Disease (IBD); Crohn's Disease(CD); Ulcerative Colitis
MeSH terms: Crohn Disease; Inflammatory Bowel Diseases; Irritable Bowel Syndrome
Study type: Interventional

Summary: 
      The study aims at showing that the susceptibility in the stress is more raised at the person
      affected digestive pathologies (SII or IBD) in forgiveness than healthy subjects.
    

Detailed description: 
      The objective of the study which we wish to lead consists in looking for, at the patients SII
      and IBD in forgiveness, the existence of a correlation between the rate of cortisol(Hormone
      of the stress) and the level of HRV (Heart Rate Variability) to estimate the inhibitive
      fronto-amygdalien tonus.

      So we make the hypothesis that the persons affected by digestive pathologies of type SII or
      IBD would present an emotional and physiological vulnerability more important than unhurt
      subjects of pathologies.
    

Intervention name(s): emotion
Intervention type(s): Behavioral
Intervention description(s): Show that the susceptibility in the stress (recording of Heart Rate Variability;viewing films;...) is more important at the person affected by digestive pathologies (SII or IBD) in forgiveness than to unhurt subjects of pathologies.
Other intervention name(s): STRESS
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: HRV; emotion; cognition; stress; cortisol; Autonomic nervous system
Antenatal Corticoid Therapy for Late Preterm Babies
Condition: Hyaline Membrane Disease; Transient Tachypnea
MeSH terms: Tachypnea; Hyaline Membrane Disease
Study type: Interventional

Summary: 
      This study aims to determine the effectiveness of antenatal corticosteroid therapy in late
      preterm babies. The investigators hypothesis is corticoid accelerates fetal lung maturation
      even after 34 weeks and reduces risk of respiratory distress syndrome and other neonatal
      morbidities.
    

Detailed description: 
      Late preterm babies have important morbidity when compared with term babies, with oxygen
      requirement and more days of hospitalization. If antenatal corticosteroid therapy is
      necessary for fetal lung maturation after 34 weeks, it remains to be established. The
      systematic review with metanalysis in Cochrane Library includes a small number of late
      preterm babies and no conclusion about effectiveness of corticoid therapy in this setting
      could be drawn. Our hypothesis is that antenatal corticosteroid therapy is effective to
      prevent respiratory disease and morbidity in late preterm babies and this study will be
      carried out to evaluate this question.
    

Intervention name(s): Betamethasone
Intervention type(s): Drug
Intervention description(s): IM administration of 12mg of betamethasone each 24 hours (total dose=24mg)
Other intervention name(s): CELESTONE SOLUSPAN (MANTECORP)
Intervention MeSH terms: Betamethasone; Betamethasone acetate phosphate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: corticoid therapy; fetal lung maturation; late preterm; respiratory distress syndrome; neonatal death
Patient Based Strategy to Reduce Errors in Diabetes Care
Condition: Diabetes Mellitus
MeSH terms: Diabetes Mellitus
Study type: Interventional

Summary: 
      This project evaluates a HPMG effort to reduce error rates through customized direct feedback
      of diabetes quality of care data to diabetes patients and their physicians. HPMG has
      routinely provided patients with personalized feedback of glucose and cholesterol test
      results since about 1997. This project will implement and evaluate the impact of this
      intervention on diabetes medical error rates and resource use.
    

Detailed description: 
      The project, Patient-Based Strategy to Reduce Errors in Diabetes Care (referred to as MOVES),
      addresses issues of overuse, under use, or misuse of care for adults with diabetes. This
      combination research and translation project has been developed as a component of the
      Pursuing Perfection initiative of HealthPartners Medical Group, with the close collaboration
      of HPMG leadership. HealthPartners Medical Group is widely regarded as a national leader in
      diabetes care, with dramatic improvements in both glucose control and cholesterol control
      over the past 8 years [Graphs].

      The MOVES study is attempting to activate patients with diabetes to be more involved in their
      care. To help patients do this, HPMG sends patients a customized summary of their care. The
      summary includes a graph of recent glucose and cholesterol test results and specific
      suggestions that may improve care. In many cases, a visit with the patient's personal
      physician is encouraged to assure ongoing progress towards important evidence-based goals in
      diabetes care.

      Physicians also receive a matched communication that indicates areas for potential
      improvement and makes technical suggestions for care based on the Staged Diabetes Management
      © protocols. The project tries to ally expert judgment with the physician's personal
      knowledge of a patient. It is felt that this approach is critical to assessing what the best
      improvement strategy may be in each individual case.

      This inexpensive customized intervention has potential to be widely disseminated and can be
      seamlessly integrated with other interventions to further achievement of clinical goals. The
      results are relevant to patients, clinicians, payers, and policymakers.
    

Intervention name(s): Customized Physician Intervention; Customized Patient Intervention
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Diabetes mellitus; Medical error rates; Pharmacotherapy
EMD for Treatment of Proximal Class-II Furcation Involvements
Condition: Generalized Aggressive Periodontitis
MeSH terms: Periodontitis; Aggressive Periodontitis
Study type: Interventional

Summary: 
      The aim of the present study is to evaluate the clinical response of proximal furcations
      treated with enamel matrix derivative proteins (EMD).
    

Detailed description: 
      Proximal class-II furcation represents a challeng to periodontal therapy. Studies show that
      the ultrasonic non-surgical therapy doesn't work in these defects and the guided tissue
      regeneration therapy with membranes also demonstrates an unpredictable improvement.
      Therefore, enamel matrix derivative proteins (EMD) have been proposed as a periodontal
      regenerative procedure due to their fundamental role in cementum development.
    

Intervention name(s): Enamel matrix derivative proteins; Open Flap debridement
Intervention type(s): Procedure; Procedure
Intervention description(s): Open flap debridement to enamel matrix derivative to treat proximal furcation involvements.; Open flap debridement will be performed to decontaminate the proximal furcation involvements.
Other intervention name(s): Surgical therapy; Surgical therapy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: enamel matrix derivative; proximal furcation; randomized clinical trial
Phase I/II Study of Chemoprevention With EGFR and COX-2 Inhibitor
Condition: Precancerous Conditions
MeSH terms: Precancerous Conditions
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Evaluate effect on cells and patient response to study medications, assess side effects of
      these medications, and evaluate chemicals in cells that may tell how the drug works, before,
      and after receiving the study medications.
    

Detailed description: 
      The purpose of this study is to evaluate the effect on cells and patient response to study
      medications, assess the side effects of these medications, and to evaluate chemicals in the
      cells that may tell how the drug works, before, and after receiving the study medications.

      Approximately 61 patients will participate at Emory Winship Cancer Institute and Emory
      Crawford W. Long Hospital in Atlanta, Georgia.
    

Intervention name(s): Erlotinib & Celecoxib
Intervention type(s): Drug
Intervention description(s): Erlotinib given orally, once daily (dose escalation from 50 mg, 75 mg, or 100 mg) continuously for 6 months in the phase I portion.
Celecoxib given 400 mg orally BID continuously for 6 months.
Other intervention name(s): OSI-774, Tarceva
Intervention MeSH terms: Celecoxib; Erlotinib Hydrochloride
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Skin Lesions; Premalignant Lesion
A Study of Experimental Medication BMS-986235 in Healthy Subjects
Condition: Mediators of Inflammation
MeSH terms: Inflammation
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a study of experimental medication BMS-986235 in healthy subjects.
    


Intervention name(s): BMS-986235; Placebo
Intervention type(s): Drug; Other
Intervention description(s): Specified dose on specified days; Specified dose on specified days
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Non-automatic Control of Gait and Posture in Obstructive Sleep Apnea Syndrome (CIH-Gait)
Condition: Obstructive Sleep Apnea Syndrome
MeSH terms: Apnea; Sleep Apnea Syndromes; Sleep Apnea, Obstructive; Syndrome
Study type: Interventional

Summary: 
      The purpose of this randomised controlled study is to determine the impact of continuous
      positive airway pressure (CPAP) versus sub-therapeutic CPAP (placebo) on the control of gait
      upon severe sleep apnea patients, based on stride time variability.
    

Detailed description: 
      As severe sleep apnea patients exhibit gait abnormalities, this is the first randomised
      controlled trial to our knowledge to assess the impact of CPAP upon gait and postural control
      in severe sleep apnea patients. Based on a dual-task paradigm, posture and gait analysis will
      be perform before and after 8 week of intervention.

      Beside gait parameters, the cerebral metabolism will be assessed using a Near Infrared
      Spectroscopy (fNIRS) device during normal walking and during walking while dual-tasking,
      using a visual and a verbal task.
    

Intervention name(s): Effective CPAP; Sub-therapeutic CPAP
Intervention type(s): Device; Device
Intervention description(s): Effective Continuous Positive Airway Pressure auto-regulated, worn all night long during 8 weeks; Sub-therapeutic Continuous Positive Airway Pressure (Sham-CPAP) worn all night long during 8 weeks
Other intervention name(s): Continuous positive airway pressure (RESMED S9™ Series); Sham-CPAP (RESMED S9™ Sham-CPAP System)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Obstructive Sleep Apnea Syndrome; Gait; Posture; Continuous Positive Airway Pressure
Effects of Blueberry Dry Powder on Glycemic Status in Subjects With Prediabetes
Condition: Prediabetes
MeSH terms: Prediabetic State; Glucose Intolerance
Study type: Interventional

Summary: 
      The purpose of the present study is to evaluate the effect of blueberry dry powder on
      glycemic status (fasting plasma glucose, 2h glucose concentration after the oral glucose
      tolerance test (OGTT), or HbA1c) in subjects with prediabetes.
    


Intervention name(s): Low dose of blueberry dry powder; High dose of blueberry dry powder
Intervention type(s): Dietary Supplement; Dietary Supplement
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention