bioihbjkbjnl/mcl2 huggingface dataset:
Different Anesthesia Maintain Protocol Effect the Outcome of the Patients
Condition: Urinary Surgery; General Anesthesia
Study type: Interventional
Phase: Phase 4

Summary: 
      This prospective open-label randomized study, patients were having elective urological
      surgery scheduled to last longer than 1 h under necessitating general anesthesia.Group-P:
      (Propofol group): 3 mg kg-1 min-1 propofol was pumped continuously after endotracheal
      intubation. Group-PAS: (Propofol and after 20 min adding Sevoflurane group): 3 mg kg-1 min-1
      propofol were pumped continuously and add 1% end-tidal sevoflurane 20 minutes after
      endotracheal intubation. Group-PS: (Propofol and Sevoflurane group): 3 mg kg-1 min-1 propofol
      were continuously pumped after endotracheal intubation, and 1% sevoflurane was inhaled
      continuously at the same time. Group-S: (Sevoflurane group): 1% sevoflurane continued to
      maintain anesthesia after endotracheal intubation. Group-PSu: (Propofol and Sufentanil
      group): 3 mg kg-1 min-1 propofol, 0.01 μ g kg-1 min-1 sufentanil were pumped continuously at
      maintain phase
    

Detailed description: 
      Group-P: (Propofol group): 3 mg kg-1 min-1 propofol was pumped continuously after
      endotracheal intubation. Group-PAS: (Propofol and after 20 min adding Sevoflurane group): 3
      mg kg-1 min-1 propofol were pumped continuously and add 1% end-tidal sevoflurane 20 minutes
      after endotracheal intubation. Group-PS: (Propofol and Sevoflurane group): 3 mg kg-1 min-1
      propofol were continuously pumped after endotracheal intubation, and 1% sevoflurane was
      inhaled continuously at the same time. Group-S: (Sevoflurane group): 1% sevoflurane continued
      to maintain anesthesia after endotracheal intubation. Group-PSu: (Propofol and Sufentanil
      group): 3 mg kg-1 min-1 propofol, 0.01 μ g kg-1 min-1 sufentanil were pumped continuously at
      maintain phase. Due to the ethical requirements of adequent analgesia, 0.3 μ g kg-1 min-1
      remifentanil was continuously pumped as background input dose during anesthesia maintenance
      in all groups.
    

Intervention name(s): Propofol; 1% Sevoflurane; 1% Sevoflurane continue; Sufentanil; 2% Sevoflurane; Propofol half
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): 5 mg kg-1 h-1 propofol was pumped continuously after endotracheal intubation.; add 1% end-tidal sevoflurane 20 minutes after endotracheal intubation.; 1% sevoflurane continued to maintain anesthesia after endotracheal intubation.; 0.01 μ g kg-1 min-1 sufentanil were pumped continuously at maintain phase; 2% sevoflurane continued to maintain anesthesia after endotracheal intubation.; 2.5 mg kg-1 h-1 propofol was pumped continuously after endotracheal intubation.
Other intervention name(s): 1% Sevoflurane; 2% Sevoflurane continue; 2.5% Propofol
Intervention MeSH terms: Sufentanil; Propofol; Sevoflurane
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Pregnancy Eating Attributes Study
Condition: Pregnancy
Study type: Observational

Summary: 
      The primary purpose of this observational cohort study is to examine the role of "food
      reward" in maternal diet and weight change during pregnancy and postpartum. The study will
      further examine the importance of food reward in the context of behavioral control and other
      related aspects of eating behavior, as well as weight-related biomedical, psychosocial and
      behavioral factors including genetics, physical activity, stress, sleep and depression. Four
      hundred and fifty women of varying baseline weight status will be enrolled early in pregnancy
      (before 12 weeks postpartum) and followed until 1 year postpartum. Assessments will occur at
      baseline (<12 weeks postpartum), during pregnancy at 13-18 weeks gestation, 16-22 weeks, and
      28-32 weeks, and postpartum at 4-6 weeks, 6 months, 9 months and 12 months. Measures will
      include assessments of food reward and related constructs, dietary intake, other health
      behaviors, and anthropometrics. Clinical data and biological specimens will be obtained.
      Infant anthropometrics and feeding practices will also be assessed. Primary exposures include
      aspects of food reward and behavioral control, which will be assessed in multiple ways to
      maximize information and utility. Primary outcomes include gestational weight gain,
      postpartum weight retention and dietary quality.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        PEAS is a prospective observational study of N=450 women without evidence of psychiatric or
        eating disorders, recruited in early pregnancy (≤12 weeks), targeting N=150 in each weight
        status group: normal weight (BMI 18.5-24.9), overweight (BMI 25-29.9) and obese (BMI >=30).
        Women will be followed through pregnancy and until 1 year postpartum, along with their
        infants from birth to 1 year, with collection of blood, stool, and urine specimens,
        previous and current medical information, dietary intake and eating behaviors,
        anthropometrics, and demographic information.
      
Biospecimen description: 
      Serum Plasma White and red blood cells Urine Stool
    
Keywords: pregnancy; gestational weight gain; dietary intake; food reward
Yoga for Aromatase Inhibitor-related Knee Pain Relief in Breast Cancer Patients
Condition: Breast Cancer; Aromatase Inhibitor; Yoga; Knee Pain
MeSH terms: Breast Neoplasms
Study type: Interventional

Summary: 
      The purpose of the study was to investigate the therapeutic effect of Yoga on aromatic
      inhibitor-induced chronic knee pain in patients with breast cancer.
    

Detailed description: 
      Estrogen plays a critical role in breast cancer growth in pre-and post-menopausal women. The
      aromatic catalyzer has relationship with biosynthesis of estrogen, therefore, aromatic
      inhibitors became as a standard therapy of breast cancer in post-menopausal women. Arthralgia
      and joint stiffness are most common side effect in aromatic inhibitor treatment. Yoga is
      benefit for the patients with chronic pain improvement, and also can improve quality of life.
      Therefore, the purpose of the present study was to investigate the therapeutic effect of Yoga
      on aromatic inhibitor-induced chronic knee pain in patients with breast cancer.The
      investigators designed a crossover study, a total of 60 patients divided equally to control
      group (massage for 6 weeks in home care) and treatment group (Yoga treatment for 12 times/6
      weeks). There is two weeks wash out period after finishing 6 weeks treatment, and then the
      patients in control group changed to treatment, in contrast, the patients in the treatment
      changed to control group. The assessment time was pre-treatment (vision 1), finishing 6 weeks
      treatment (vision), finishing 6 weeks treatment after crossover (vision 3). The major
      assessment was brief pain inventory scores changed The results in the present study predict
      Yoga treatment for 6 weeks can improve aromatic inhibitor-induced knee pain and also can
      improve quality of life in patients with breast cancer.
    

Intervention name(s): yoga
Intervention type(s): Other
Intervention description(s): yoga is a mind-body practice that guides the body through a series of poses and breathing exercises
Other intervention name(s): massage
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: The investigators designed a crossover study, a total of 60 patients divided equally to control group (massage for 6 weeks in home care) and treatment group (Yoga treatment for 12 times/6 weeks).
Masking: None (Open Label)
Primary purpose: Supportive Care
Electroencephalogram (EEG) Triggered Functional Magnetic Resonance Imaging (fMRI) in Epilepsy Patients
Condition: Epilepsy
MeSH terms: Epilepsy
Study type: Interventional

Summary: 
      A prospective exploratory study in patients with drug resistant epilepsy with a target
      comparison of long term outcome. NeuroScan software modules and a MagLink will be used to
      acquire EEG in combination with MRI/fMRI data. The MagLink system is used for obtaining
      integrated EEG and Event Related Potential (ERP) recordings while the subject is inside the
      MRI machine, without compromising the raw EEG data.
    


Intervention name(s): EEG Triggered fMRI using Micro Maglink
Intervention type(s): Other
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: EEG triggered; fMRI; epilepsy; intractable
A Study of LY2189102 in Patients With Type 2 Diabetes
Condition: Type 2 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 2

Summary: 
      Study to evaluate the safety, tolerability and efficacy of LY2189102 in patients with type 2
      diabetes.
    


Intervention name(s): LY2189102; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Participants received 2 subcutaneous (SC) injections weekly for 12 weeks.; Participants received 2 SC injections weekly for 12 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Diabetes; Type 2 Diabetes
The Clinical Impact of L-PRF, H-PRF or the Use of Surgical Stent on Palatal Donor Site Healing.
Condition: Lack of Keratinized Gingiva
Study type: Interventional
Phase: Phase 1

Summary: 
      A Randomized, Three Parallel Arms Clinical Trial to evaluate s the clinical impact of L-PRF
      vs H-PRF vs Palatal stent on the healing of the donor palatal site.
    

Detailed description: 
      A Randomized, Three Parallel Arms Clinical Trial. The primary objective is to assess the
      clinical impact of L-PRF vs H-PRF vs Palatal stent on the healing of the donor palatal site
      by comparing the percentage of re-epithelization of the palatal donor site at 5, 10, 14 and
      21 days using a standardized intraoral palatal photo.

      The secondary objective is to compare the post op discomfort between the three groups during
      the healing period daily for 2 weeks using the Visual Analogue Scale (VAS) and Analgesic
      consumption.

      All subjects from the University of Kentucky College of Dentistry clinics. Subjects that are
      coming increasing the width of keratinized tissue or for the treatment of gingival recession,
      and match the inclusion criteria will be told about the research and offered the opportunity
      to participate.
    

Intervention name(s): L-PRF (Leucocyte- platelet rich fibrin); H-PRF (Horizontal -platelet rich fibrin); Surgical stent
Intervention type(s): Biological; Biological; Device
Intervention description(s): Leucocyte-Platelet rich fibrin is a high density fibrin clot. it serves as a biological healing matrix by supporting cell migration and cytokine release, expanding the range of its potential applications greatly. Patient's own blood is centrifuged using (Intra-spin) FDA approved centrifuge on 45 degrees angle on 2700 rpm for 12 minutes.; Platelet rich fibrin is a high density fibrin clot. it serves as a biological healing matrix by supporting cell migration and cytokine release, expanding the range of its potential applications greatly.Horizontally centrifuged platelet rich fibrin using (Bio-prf) centrifuge on 700 g force for 8 minutes. On a horizontal centrifugation, the cells separate much more efficiently throughout the entire membrane. This leads to better layer separation and also favors cells that are evenly distributed throughout the PRF clot.; An essix surgical stent will be obtained using a high vacuum suction and used to protect the denuded donor site after suturing the wound. (Biostar® Scan/Biostar®V) will be used to make the stent.
Other intervention name(s): Essix retainer
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Ventriculomegaly and Gait Disturbance in the Senior Population in the Region of Västerbotten
Condition: Idiopathic Normal Pressure Hydrocephalus (INPH); Brain Diseases; Central Nervous System Diseases; Dementia; Gait Disorders, Neurologic; Hydrocephalus, Normal Pressure
MeSH terms: Dementia; Nervous System Diseases; Hydrocephalus; Brain Diseases; Central Nervous System Diseases; Hydrocephalus, Normal Pressure; Gait Disorders, Neurologic
Study type: Observational

Summary: 
      Idiopathic normal pressure hydrocephalus (INPH) is a treatable disease of the elderly,
      typically causing gait impariment, dementia and urinary incontinence. The objective of this
      study is to make an epidemiological survey of INPH in Umeå, Sweden. Subjects with
      self-perceived gait impairments will be identified through a questionnaire. They will go
      through clinical examinations and have an MRI of the brain. A control population will also be
      investigated to enable comparisons between the populations. The main hypothesis is that the
      prevalence of INPH in the population is higher than what is previoulsy known.
    


Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        The number of people, aged 65-84 years and living in Umeå, is approximately 18 000. Of
        these, 6500 will be randomly selected from the Swedish population registry. They will be
        asked to answer a mailed-out questionnaire regarding self-perceived gait impairment. Those
        with self-percieved gait impairment will be invited for clinical examinations as cases and
        a random selection of those without self-percieved gait impairment will be invited to
        participate in clinical examinations as controls.
      
Keywords: Idiopathic Normal Pressure Hydrocephalus
Comparison of Different Methods of Nasogastric Tube Insertion in Anesthetized and Intubated Patients
Condition: Disorder of Abdomen
Study type: Interventional

Summary: 
      The primary aim of this study is to investigate the difference in the first attempt and
      overall success rate of different techniques for insertion of nasogastric tube. Secondary aim
      is to investigate the difference of the duration of insertion using the selected technique,
      complications during insertion such as kinking, knotting, mucosal bleeding
    

Detailed description: 
      Two hundred adult patients, who received general anaesthesia for elective abdominal surgeries
      that required nasogastric tube insertion, will be randomized by means of a computer-generated
      randomization order into four groups: Conventional group (Group C), head in the lateral
      position group (Group L), endotracheal tube assisted group (group ET) and video laryngoscope
      group (group MG).

      Success rate of the selected technique (first attempt, second attempt and overall), duration
      of insertion for selected technique, complications such as kinking and mucosal bleeding will
      be noted.
    

Intervention name(s): conventional technique; head in the lateral position technique; endotracheal tube assisted technique; videolaryngoscope technique
Intervention type(s): Procedure; Procedure; Procedure; Procedure
Intervention description(s): the nasogastric tube will be inserted gently through a selected nostril with the head being maintained in the neutral position.; the patient's head will be turned to the right lateral position. Nasogastric tube will be inserted through the right nostril without any maneuvers of the neck.; Nasogastric tube will be inserted the trimmed 7.5 mm internal diameter endotracheal tube what cut proximal end with sterile scissors and endotracheal tube will be advanced blindly into the oral cavity to a depth of approximately 18 cm without laryngoscope together the nasogastric tube.; Nasogastric tube was inserted transnasally and advanced into esophagus under direct vision.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: nasogastric tube insertion; Video laryngoscope; success rate
The Impact of Anesthesia on the Absorption of Glycine in Operative Hysteroscopy: a Randomized Controlled Trial
Condition: The Absorption of Glycine in Operative Hysteroscopy
Study type: Interventional

Summary: 
      This study aimed to compare two types of anesthesia (general anesthesia and local anesthesia
      with sedation) on the absorption of glycine in operative hysteroscopy.
    

Detailed description: 
      As a minimally invasive procedure, operative hysteroscopy has gained popularity in the past
      two decades and became a standard surgical treatment for abnormal uterine bleeding
      unresponsive to medical management. Despite its increasing use, little information is known
      on the predictors of its potential complications. The absorption of glycine has been reported
      as the most common complication of this procedure and it remains an unpredictable
      complication that may lead to life-threatening conditions.

      This randomized controlled trial is conducted in two centers: a tertiary care center and in a
      community hospital over a period of 18 months. This study aimed to compare two types of
      anesthesia on the absorption of glycine in operative hysteroscopy. Eligible patients
      undergoing operative hysteroscopy for abnormal uterine bleeding are randomized in two groups:
      group general anesthesia and group local anesthesia with sedation.
    

Intervention name(s): General anesthesia; Local anesthesia with sedation
Intervention type(s): Procedure; Procedure
Intervention description(s): For women in the general anesthesia group, general anesthesia is induced using midazolam 1-3 mg, sufentanil 0.15-0.25 mcg/kg and propofol 1-3 mg/kg. Rocuronium 0.6 mg/kg is allowed. Anesthesia is maintained with sevoflurane titrated to maintain a blood pressure within 20% of preoperative normal and, if needed, ephedrine can be used for this purpose. Patients are ventilated in a normocapnic range with a positive end-expiratory pressure of 3 to 5 mmHg.; For women in the local anesthesia group a paracervical block is performed by the gynecologist using a total of 20 mL of 1% lidocaine intracervically at 2, 4, 7 and 10 o'clock positions and in the area of uterosacral ligaments. Once the block completed, the surgeon waits at least five minutes before performing cervical dilatation to allow for sufficient analgesia. Intravenous sedation consists of midazolam, sufentanil and propofol administered by the anesthesiologist in sufficient doses to maintain a spontaneous ventilation with a Ramsay score < 4.
Other intervention name(s): Midazolam; Sufentanil; Propofol; Rocuronium; Sevoflurane; Ephedrine; Lidocaine; Midazolam; Sufentanil; Propofol
Intervention MeSH terms: Lidocaine; Ephedrine; Midazolam; Sufentanil; Dsuvia; Anesthetics; Propofol; Sevoflurane; Rocuronium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Glycine absorption; Operative hysteroscopy; Endometrial resection; General anesthesia; Local anesthesia
Motor Performance in Parkinson's Disease After High Intensive Exercise or Deep Brain Stimulation
Condition: Parkinson's Disease
MeSH terms: Parkinson Disease
Study type: Interventional

Summary: 
      The purpose of this study is (1) to provide quantitative information of the motor
      manifestations of Parkinson's disease and (2) to quantify the effect of high intensive
      antigravity locomotor exercise or Deep Brain Stimulation implantations in Parkinson's
      disease.
    


Intervention name(s): High intensive antigravity locomotor exercise; Deep Brain Stimulation
Intervention type(s): Other; Procedure
Intervention description(s): High intensive antigravity locomotor exercise, 3 sessions/week, for 8 weeks.; Deep Brain Stimulation implantation
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Chemotherapy-Induced Cognitive Impairment
Condition: Cognitive Symptoms
MeSH terms: Neurobehavioral Manifestations; Chemotherapy-Related Cognitive Impairment; Cognitive Dysfunction
Study type: Observational

Summary: 
      The investigators overall research hypothesis is that systemic chemotherapy induces
      structural changes in the white matter of the brain as demonstrated with Diffusion Tensor
      Imaging (DTI) and functional changes in well-defined cortical neural networks as demonstrated
      by resting-state functional connectivity MRI (rs-fcMRI). The investigators believe these
      structural and functional changes are responsible for the cognitive symptoms associated with
      chemotherapy-induced cognitive impairment (CICI).

      The Specific Aim for this study is:

      To assess the impact of chemotherapy on structural white matter as defined by DTI and
      functional cognitive networks as defined by rs-fcMRI by comparing a sample of breast cancer
      survivors with self-reported CICI to breast cancer survivors without CICI.

      Hypothesis: Post-chemotherapy breast cancer patients with self-reported CICI will have
      abnormal structural connections characterized by DTI-defined disruptions in fractional
      anisotropy (FA) and mean diffusivity (MD) and abnormal functional connectivity characterized
      by rs-fcMRI-defined disruptions in cognitive networks when compared to patients without
      self-reported CICI.
    

Detailed description: 
      Chemotherapy has been linked to cognitive impairments among breast cancer patients,
      especially in the domains of executive function (planning and problem solving), attention,
      learning, and information processing. The etiology of these chemotherapy-associated
      impairments remains unknown, although recent neuroimaging studies suggest that disruption of
      white matter integrity may play a role. With continued use of chemotherapy in breast cancer
      patients, this study's novel use of functional neuroimaging will be significant to better
      inform practitioners and patients of potential consequences to anticipate and serve as a
      starting point in the development of therapeutic interventions.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Breast cancer surviviors from Washington University's Siteman Cancer Center and from
        community at large.
      
Keywords: Chemotherapy; Breast Cancer; Cognitive Impairment; Chemo brain