bioihbjkbjnl/mcl2 huggingface dataset:
Direct Repair Surgery for Spondylolysis of Lumbar in Young Population
Condition: Spondylolysis
MeSH terms: Spondylolysis
Study type: Interventional

Summary: 
      Lumbar spondylolysis is a relatively common condition that causes severe and perennial back
      pain in young populations. Conservative treatment of this condition may be futile, and may
      eventually require surgical treatment such as direct repair of pars defect and a segmental
      lumbar fusion with an anterior or posterior approach. Recently, of surgical treatment methods
      for spondylolysis, direct repair surgery of pars defect has been focused due to its inherited
      strengths. Most importantly, fusion surgery caused the affected segment to lose the nature
      range of motion and furthermore adjacent segment to be adversely affecting such as adjacent
      disc disease or degeneration, while direct repair theoretically could preserve the motion of
      the affected segment, which do not cause the adjacent segment problems as being the fusion
      surgery, as well as could produce better surgical outcomes with relatively less invasive
      technique as compared to fusion surgery. Moreover, previous articles have demonstrated that
      the direct repair surgery for spondylolysis of lumbar spine could achieve great functional
      and radiological outcomes. However, most of the previous studies was conducted using lower
      level designed study such as retrospective and small sample size, thereby prior literature
      does not provide clear information on the therapeutic outcome of direct repair for lumbar
      spondylolysis, especially for managing spondylolysis of young population.

      Therefore, The investigators aimed to evaluate and determine the outcomes of direct repair
      surgery for lumbar spondylolysis in young population. To our knowledge, this is the first
      report that describes the functional and radiological outcomes of direct repair for
      spondylolysis in young populations with prospective cohort study design and relatively large
      sample size.
    


Intervention name(s): Direct repair of pars defect
Intervention type(s): Procedure
Intervention description(s): Direct repair at pars defect was performed with 4.5mm cortical screw in young spondylolytic patients.
Other intervention name(s): 4.5mm cortical screw
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Spondylolysis; Lumbar spine; Young population; Direct repair; Union rate; Functional outcome
Novel Behavioral Intervention to Enhance Social Connections in Anxiety and Depression
Condition: Anxiety Disorders and Symptoms; Depression
MeSH terms: Depression; Depressive Disorder; Anxiety Disorders
Study type: Interventional

Summary: 
      The overall goal of this project is to develop a novel transdiagnostic behavioral treatment
      -- social approach training -- intended to enhance positive social connections in individuals
      with elevated anxiety and/or depression. Social relationship impairments are pervasive and
      debilitating consequences of anxiety and depression. Existing treatments have some beneficial
      impact on social functioning; however, many people continue to have few and/or poor quality
      relationships following treatment, even after experiencing symptom relief. This study will
      evaluate the effects of social approach training on the brain systems that have been shown to
      be important for establishing positive connections with others. Approximately 60 individuals
      (ages 18-55) seeking treatment for anxiety or depression will participate in this study.
      Participants will be randomly assigned with equal probability to one of two versions of
      social approach training (5 or 10 sessions) or a waitlist (assessment only) control group.
      Participants will be assessed at baseline and post-treatment and compared on measures
      assessing brain responses to social reward (primary outcome), as well as physiological,
      behavioral, and emotional responses to social reward (secondary outcomes). It is hypothesized
      that participants assigned to social approach training will display greater increases from
      pre- to post-treatment in activity in brain systems that regulate the processing of social
      reward (e.g., striatum) relative to participants in the control group. This study will also
      determine whether the 5- vs. 10-session versions of the treatment program result in
      meaningful differences, compared to each other, in how the brain responds to social reward.
    


Intervention name(s): Social Approach Training (5 sessions); Social Approach Training (10 sessions)
Intervention type(s): Behavioral; Behavioral
Intervention description(s): 5 one-hour, clinician-administered treatment sessions focused on presenting rationale and instructions for completing positive activity exercises (e.g., gratitude, acts of kindness) designed to increase positive emotions, cognitions, and behaviors.; 10 one-hour, clinician-administered treatment sessions focused on presenting rationale and instructions for completing positive activity exercises (e.g., gratitude, acts of kindness) designed to increase positive emotions, cognitions, and behaviors.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Efficacy of Anthocyanin Mouthrinse for Oral Anti-inflammation From Orthodontic Treatment
Condition: Inflammation of Mouth; Acute Mucous Inflammation
MeSH terms: Mucositis; Stomatitis; Inflammation
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      The purpose of this study is to compare the oral inflammatory reduction effect caused from
      orthodontic treatment of anthocyanin and placebo mouthrinse.
    

Detailed description: 
      Multiple inflammatory lesions caused from orthodontic treatments are commonly found in these
      patients and the irritations from the insertion of the orthodontic wire are hard to apply the
      topical cream or gel. Standard treatment to prevent oral mucosal irritation caused from
      orthodontic brackets and wires is an orthodontic wax to cover the appliances. However, the
      covering wax is just a prophylactic measure to protect the mucosal irritation. Thus, the
      patients still need a specific treatment for their oral inflammatory condition. Developing a
      product that can treat entire inflammatory areas in oral cavity, promote oral hygiene, and
      anti-fungal would be beneficial and useful for the orthodontic treatment. Anthocyanins, one
      of a natural compound from red, blue, purple vegetables, fruits, and flowers, have many
      beneficial effects including anti-inflammation and the most important effect superior to
      steroid usage is anti-candidiasis. Interesting in anthocyanins as the natural treatment, has
      drawn attention due to the benefits in oral inflammation. Previous study on the effect of a
      topical anthocyanin gel demonstrated positive effect of topical anthocyanins gel against oral
      inflammation in human subjects at 6 weeks. Unfortunately, anthocyanin is not stable and
      easily to be degraded. Therefore, stabilized anthocyanin oral formulation needs to be
      developed and the formulation needs to provide stable and active anthocyanins in suitable
      oral formula. This study aims to prepare and investigate effects of anthocyanin complex in
      order to formulate the mouthrinse for anti-inflammation caused by orthodontic treatment.
      Thus, to prepare and investigate the effects of anthocyanin activities after forming
      complexation in order to formulate the mouthrinse would be evaluated. In addition, the
      examination of anti-oral inflammation caused by orthodontic treatment by anthocyanin complex
      in clinical trial will be conducted.
    

Intervention name(s): Anthocyanin; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Anti-inflammation gel; Blank gel
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Anthocyanin; Inflammation; Orthodontic treatment
The Effects of Sacroiliac Joint Manual Therapy on Autonomic Nervous System and Lower Abdominal Pain in Women in Their 20s With Primary Dysmenorrhea
Condition: Primary Dysmenorrhea
MeSH terms: Dysmenorrhea; Abdominal Pain
Study type: Interventional

Summary: 
      Disorders of the autonomic nervous system are considered another possible cause of
      dysmenorrhea. spinal manual threapty is acting on the parasympathetic and sympathetic nerves.

      The sacrum affects all vertebrae, which affects the position of this bone, is thought to have
      a lot to do with dysmenorrhea.

      In this study, by applying spinal manual threapty threapty to the sacroiliac joint in women
      in their 20s with primary dysmenorrhea, we tried to present an effective treatment method by
      evaluating the function of the autonomic nervous system and confirming the occurrence of pain
      in the lower abdomen.
    


Intervention name(s): spine manual therapy; Superficial heat therapy
Intervention type(s): Behavioral; Device
Intervention description(s): The manual treatment method applied to the sacroiliac joint used high-velocity, low amplitude (HVLA).; In the physical therapy used in this study, it was applied for 20 minutes using conventionally used superficial heat therapy.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Effect of Probiotic on the Innate and Adaptive Host Response to Rhinovirus (EPIARR)
Condition: Common Cold
MeSH terms: Common Cold
Study type: Interventional

Summary: 
      The study is designed to assess the effect of ingestion of a probiotic on innate and adaptive
      host responses to rhinovirus infection.
    

Detailed description: 
      The common cold is a ubiquitous illness of man that is associated with significant medical
      and socioeconomic consequences. Current treatments for the common cold that have proven
      efficacy are limited to pharmacologic agents that are directed at specific symptoms. These
      treatments- antihistamines, nasal decongestants and analgesics- have limited effectiveness,
      generally relieving the target symptom by 15-25% at the peak of activity, and are associated
      with bothersome side effects. There are no currently effective treatments for prevention of
      rhinovirus infections.

      Probiotics have been defined by FAO/WHO as "Live microorganisms which when administered in
      adequate amount confer a health benefit on a host." The most common probiotics belong to
      Lactobacillus or Bifidobacterium genera. Bifidobacteria are natural human gut inhabitants
      that were discovered over a hundred years ago from the feces of breast-fed infants. The study
      product Bifidobacterium animalis subspecies (subsp.) lactis Bl-04 (Bl-04) has been
      genetically characterized as B. animalis subsp. lactis by 16S rRNA gene sequencing and full
      genome sequence comparison. Bl-04 has been deposited in the American Type Culture Collections
      safe deposit as SD5219.

      This study will test the hypothesis that ingestion of a probiotic Bifidobacterium animalis
      subsp. lactis Bl-04 will alter the innate and adaptive host response to rhinovirus infection.
    

Intervention name(s): Bifidobacterium lactis Bl-04; Placebo; Rhinovirus
Intervention type(s): Dietary Supplement; Dietary Supplement; Biological
Intervention description(s): The study product will be a 2*109 cfus of probiotic Bifidobacterium lactis Bl-04 mixed with 1g of sucrose as a carrier.; Placebo will be 1g of sucrose that has identical appearance, smell, and taste with the study product.; rhinovirus for experimental challenge
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: Common cold
A Dose-ranging, Study of the Safety and Efficacy of Subcutaneous Injections of LIPO-102 Compared With Placebo for the Reduction of Abdominal Subcutaneous Adiposity
Condition: Weight
MeSH terms: Obesity
Study type: Interventional
Phase: Phase 2

Summary: 
      LIPO-102 is under evaluation for treatment of abdominal adiposity
    


Intervention name(s): LIPO-102; LIPO-102 Low; LIPO-102, Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): LIPO-102 High dose; LIPO-102 Low dose; Placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Treatment of abdominal adiposity
The Impact of School Teachers in Care Navigation and Signposting Dental Caries in Primary School Children
Condition: Dental Caries in Children
MeSH terms: Dental Caries
Study type: Interventional

Summary: 
      The study aims to investigate the role of school teachers in care navigation and signposting
      dental caries in primary school children.
    

Detailed description: 
      Dental caries is a multifactorial disease with high prevalence in children. Dental caries is
      a global public health problem with detrimental impact in developing countries. Despite
      advances in caries management and detection poorer countries continue to suffer a high burden
      of disease. Advances in care navigation and sign-posting concepts are increasingly being
      utilized in general health care to aid early diagnosis and ease the burden of disease in
      poorer communities. This study aims to investigate the role of primary school teachers as
      care navigators with regard to dental caries in children.
    

Intervention name(s): Signpost caries
Intervention type(s): Diagnostic Test
Intervention description(s): Identify carious lesion according to ICCMS visual criteria
Other intervention name(s): signpost dental caries
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: non-randomized parallel design
Masking: None (Open Label)
Primary purpose: Diagnostic
An Assessment of 4 Different Bearing Types in Hip Replacement Types to Analsye the Lowest Wear Rates of Polyethylene
Condition: Arthroplasty Complications; Hip Arthritis
MeSH terms: Arthritis
Study type: Interventional

Summary: 
      The aim of the study is to assess the ideal bearing surfaces in hip replacement by comparing
      4 different combinations. In a hip replacement this means what the head and the socket liner
      are made of.
    

Detailed description: 
      In hip replacements, arguably the most important thing for survivorship is what rubs against
      what.

      Traditionally surgeons used metal (Cobalt-Chrome) against a conventional polyethylene
      (plastic). More recently (around 15 years ago) a newer more dense type of polyethylene
      (called XLPE) had been developed and a new type of head called Oxidized Zirconium was also
      developed.

      In this trial, adults who were undergoing hip replacements were randomized assigned into one
      of the four groups:

      Group 1: old plastic vs metal head Group 2: Old plastic against Oxidized Zirconium Group 3:
      New plastic versus metal head Group 4 New plastic vs Oxidized Zirconium

      All patients were followed up for a minimum of 10 years to assess which group wore the most
      amount of polyethylene and which group had the best survival rate.
    

Intervention name(s): Highly Cross Linked Polyethylene and oxidized zirconium femoral head
Intervention type(s): Device
Intervention description(s): Differing bearing surfaces:
Conventional polyethylene versus cobalt Chrome heads
Conventional polyethylene versus Oxidized Zirconium heads
Highly Cross-linked polyethylene versus Cobalt Chrome heads
Highly Cross-linked polyethylene versus Oxidized Zirconium heads
Other intervention name(s): Varilast - from Smith & Nephew
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Health Services Research
Keywords: Hip arthroplasty; Tribology; wear
Way to Be Active 2 (Lotteries)
Condition: Sedentary Employees
Study type: Interventional

Summary: 
      Employers are increasingly looking for opportunities to motivate sedentary employees to
      become more physically active. Workplace walking programs have had mixed success and
      typically show most improvement among participants that are already fairly active at a
      baseline. The goal of this study is to determine whether a financial incentive program can
      motivate sedentary employees to increase the number of steps they walk per day to meet a
      minimum threshold.

      Our primary outcome measure is the proportion of days a minimum activity of 7000 steps or
      more is achieved. We will assess outcomes each week for 3 months using incentives followed by
      3 months of follow-up without incentives. Secondary outcomes will include the average steps
      walked per day.
    


Intervention name(s): Basic Lottery; Combined Lottery; Jackpot Lottery
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Participants who meet their daily step goals will be eligible for a daily lottery. They will have about a 1 in 4 chance of winning $5. Expected value is about $1.40 per person per day.; Participants who meet their daily step goals will be eligible for a daily lottery. They will have about a 1 in 4 chance of winning $5 and a 1 in 100 chance of winning $50. Expected value is about $1.40 per person per day.; Participants who meet their daily step goals will be eligible for a daily lottery. They will have about a 1 in 400 chance of winning $500. Expected value is about $1.40 per person per day.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: Sedentary; Behavioral Economic Intervention; Team Studies; Financial Incentives; Workplace Wellness; Team Incentives
Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste
Condition: Gingivitis
MeSH terms: Gingivitis
Study type: Interventional
Phase: Phase 4

Summary: 
      The objective of this study is to evaluate the clinical efficacy of a toothpaste containing
      stannous fluoride as compared to Colgate Fluoride Toothpaste in reducing plaque and
      gingivitis - a three- month study.
    

Detailed description: 
      This was a 6-month, randomized, single-center, parallel group, double-blinded, clinical
      research study to assess the clinical efficacy of two toothpastes containing stannous
      fluoride (SnHW and CPH) as compared to Regular Fluoride Toothpaste on the reduction of
      established dental plaque and gingivitis in adults.
    

Intervention name(s): Colgate Total SF; Colgate Cavity Protection toothpaste
Intervention type(s): Drug; Drug
Intervention description(s): 1100 ppm F Colgate Total Clean Mint White Paste Toothpaste is a test treatment; 0.76% monofluorophosphate (1000 ppm MFP), Colgate Cavity Protection toothpaste is a control treatment.
Other intervention name(s): Stannous Fluoride; CDC
Intervention MeSH terms: Listerine; Fluorides; Sodium Fluoride; Tin Fluorides
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: This was a 6-month, randomized, single-center, parallel group, double-blinded, clinical research study to assess the clinical efficacy of two toothpastes containing stannous fluoride (SnHW and CPH) as compared to Regular Fluoride Toothpaste on the reduction of established dental plaque and gingivitis in adults.
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Study on the Safety of BAY 63-2521, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given as a Single Oral Dose of 1 mg Tablet in Participants With Impaired Liver Function and Healthy Participants Matched for Age-, Gender-, and Weight
Condition: Clinical Pharmacology
Study type: Interventional
Phase: Phase 1

Summary: 
      BAY 63-2521 is intended to be used for a disease that affects the blood flow through the
      lungs. Renal impairment is a common condition in patients with this disease. The goal of the
      study is to learn more about the safety of BAY 63-2521, how it is tolerated and the way the
      body absorbs, distributes and gets rid of the study dug given as a single oral dose of 1 mg
      tablet in participants with renal impairment and healthy participants matched for age-,
      gender-, and weight
    


Intervention name(s): Riociguat (Adempas, BAY 63-2521)
Intervention type(s): Drug
Intervention description(s): 0.5 mg riociguat as an immediate-release (IR) tablet
Intervention MeSH terms: Riociguat
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Myo-inositol and Vitamin D3 During IVF
Condition: Female Infertility
MeSH terms: Infertility; Infertility, Female
Study type: Interventional

Summary: 
      Administration of a multicomponent dietary supplement (myo-inositol, vitamin D3, folic acid
      and melatonin) to women undergoing IVF procedures.

      The aim of the study is to monitor the effects on the pregnancy, implantation and abortion
      rates.
    


Intervention name(s): control group; study group
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 2 g Myo-Inositol, 50 mg Alpha-Lactalbumin and 200 µg folic acid (1 sachet/day in the morning): from the first day of the menstrual cycle until 14 days after embryo transfer. If pregnancy occurs, until the 12th week of gestation.
600 mg Myo-Inositol, 200 µg folic acid, 1 mg melatonin (1 soft capsule/day in the evening): from the first day of the menstrual cycle until hCG administration. If pregnancy occurs, until the 12th week of gestation.; 2 g Myo-Inositol, 50 mg Alpha-Lactalbumin and 200 µg folic acid (1 sachet/day in the morning): from the first day of the menstrual cycle until 14 days after embryo transfer. If pregnancy occurs, until the 12th week of gestation.
600 mg Myo-Inositol, 200 µg folic acid, 1 mg melatonin (1 soft capsule/day in the evening): from the first day of the menstrual cycle until hCG administration;
600 mg Myo-Inositol, 200 µg folic acid, 1 mg melatonin, 50 µg vitamin D3 as cholecalciferol (1 soft capsule/day in the evening) substitutes the previous treatment at hCG administration and lasted until 14 days after embryo transfer. If pregnancy occurs, until the 12th week of gestation.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Study To Investigate The Metabolism And Excretion Of 14C SB-751689 Given To Healthy Males And Postmenopausal Women
Condition: Osteoporosis
MeSH terms: Osteoporosis
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will examine the biological fate of radioactive SB-751689 administered to healthy
      males and healthy postmenopausal women. Subjects will receive a single oral dose of
      radioactive SB-751689. Excreta and blood samples will be taken over the course of 7 days.
      This study will help determine the major route of elimination of SB-751689 in humans. It will
      also provide samples (blood, plasma, urine, and stools) for analysis of metabolites, if any.
    


Intervention name(s): SB-751689
Intervention type(s): Drug
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: SB-751689; osteoporosis; metabolism; excretion