bioihbjkbjnl/mcl2 huggingface dataset:
The Prognosis of Acute Myocardial Infarction in Xinjiang
Condition: Acute Myocardial Infarction
MeSH terms: Myocardial Infarction; Infarction
Study type: Observational

Summary: 
      This study is to build a Xinjiang people registry and surveillance system for acute
      myocardial infarction(AMI) information about patient's basic information, patient
      characteristics, diagnostic test mode, the program of treatment and hospitalization outcomes
      including mortality, treatment complications, the cost of hospitalization and follow-up
      events (death, major adverse cardiac events, stroke, heart failure) of AMI patients; And to
      propose scientific precaution strategies aimed to prevent effectively from the incidence of
      AMI; And to optimize the management and outcomes of AMI patients through implementation of
      guideline recommendations in clinical practice, and to perform analyses and development of
      effective treatment strategies and predictive models of clinical ourtcomes.
    

Detailed description: 
      The aim of the study is to establish the platform for surveillance, clinical research and
      translational medicine in Xinjiang , designed to provide a foundation for future quality
      improvement and research as well as facilitate efforts to improve the quality of AMI patient
      care , translate research into improved care for patients and thus decrease morbidity and
      mortality associated with AMI.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Acute myocardial infarction patients in hospitalized of The First Affiliated Hospital of
        Xinjiang Medical (include diagnosed acute ST-elevation or non ST-elevation myocardial
        infarction)
The Effect and Safety of Moxibustion Therapy for Overactive Bladder Patients
Condition: Overactive Bladder; Hyperthermia; Urinary Frequency or Urgency Adverse Event; Lower Urinary Tract Symptoms
MeSH terms: Urinary Bladder, Overactive; Lower Urinary Tract Symptoms; Hyperthermia
Study type: Interventional

Summary: 
      This pragmatic randomized controlled study aimed to evaluate the effectiveness and safety of
      moxibustion therapy on overactive bladder (OAB) patients.
    

Detailed description: 
      Patients who diagnosed as overactive bladder aged 20 to 75 years old will be divided into two
      groups, one is moxibustion-therapy and the other is waiting-list group.

      Patients who belong to moxibustion therapy group will be treated moxibustion for 12 times by
      a Korean Medicine doctor.

      Patients who belong to waiting-list group will be prohibited to get any treatment including
      moxibustion for relieve the symptoms of overactive bladder, and the same moxibustion therapy
      with moxbiustion-therapy group will be conducted after 4 weeks.

      Overactive bladder symptom score (OABSS), overactive bladder-validated 8-question (OAB-V8)
      will be measured to evaluate the effectiveness.

      The number of side effect will be measured to evaluate the safety.

      The skin temperature of CV4, SP6 and LR3, and the tympanic temperature will be measured to
      study treatment mechanism.
    

Intervention name(s): moxibustion
Intervention type(s): Device
Intervention description(s): The treatment schedule is three times per week for four weeks. Indirect moxa pillars and indirect-container moxibustion will be used.
Other intervention name(s): moxa pillar
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: moxibustion
The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults
Condition: Impairment of Oral Perception; Insulin Resistance
MeSH terms: Insulin Resistance
Study type: Interventional

Summary: 
      The purpose of this study is to investigate the effects of dietary exposure to artificial
      sweeteners on taste sensitivity, preference and brain response in adults. The investigators
      hypothesize that dietary exposure to artificial sweeteners (sucralose) will decrease
      sensitivity to taste, shift preference of sweet and savory taste to a higher dose, and reduce
      brain response in amygdala to sweet taste compared to sucrose.
    

Detailed description: 
      We aim to identify neural factors that contribute to taste intensity perception in humans and
      to determine environmental mechanisms that contribute to variation in taste sensitivity.
      Significant controversy surrounds the possibility that consumption of artificial sweeteners
      (AFS) leads to weight gain. Given that the five FDA approved AFSs are found in thousands of
      foods (Yang 2010) this marks a clear and significant gap in knowledge. Our preliminary data
      demonstrate a 3-fold decrease in sweet taste sensitivity following consumption of a beverage
      sweetened with two packets of Splenda for just 10 days. These data provide strong evidence
      that repeated exposure to sucralose reduces perception of sweet taste intensity, most likely
      by down-regulation of the sweet taste receptor. Therefore, it is imperative that we gain a
      greater understanding of the physiological consequences of AFS, since alterations in sweet
      taste perception, metabolism and brain reward that occur in response to AFS exposure may
      promote weight gain.
    

Intervention name(s): Sucralose; Sucrose; Sucralose + maltodextrin; Sucralose + Sucrose
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): 2 packets per 12 fl oz; equisweet to sucralose; sucralose plus equicaloric (to sucrose) maltodextrin; half the amount of sucralose plus equicaloric sucrose
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Effectiveness of Tai Chi Exercise Program in Scleroderma Patients
Condition: Tai Chi
MeSH terms: Scleroderma, Systemic; Scleroderma, Diffuse
Study type: Interventional

Summary: 
      Because of multiple system involvement, patients with Scleroderma have complaints such as
      fatigue, sleep disturbances, functional limitations, skin deformations, pain, swollen hands
      and joint pain. The aim of this study is to investigate the effect of Tai Chi exercise
      program on trunk endurance, balance, sleep, fatigue, anxiety and depression in patients with
      scleroderma.
    

Detailed description: 
      In the study, which will be planned as a randomized controlled parallel group, the effects of
      Tai Chi in SS patients are compared with the home exercise group. Evaluations before and
      after the treatment will make by a physiotherapist. Training of Tai Chi will supervised by an
      experienced and certified physiotherapist.

      Lateral Bridge Test , Berg Balance Scale, Pittsburg Sleep Quality Index , Fatigue Severity
      Scale and Fatigue Impact Scale , Hospital Anxiety and Depression Scale will be used
      evaluation before and after training.
    

Intervention name(s): Tai Chi
Intervention type(s): Other
Intervention description(s): Home exercises will include warm-up and cool-down exercises, stretching for shoulder, hamstring and erector spinae muscles, strengthening exercises for abdominal and back muscles.
Other intervention name(s): Home exercises
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: randomized controlled parallel group
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Scleroderma; Tai Chi; sleep; fatique; depression; anxiety
Comparison of a Two Ready-to-use Supplementary Foods of Differing Protein Quality for the Treatment of MAM.
Condition: Malnutrition
MeSH terms: Malnutrition
Study type: Interventional

Summary: 
      This is a prospective, randomised, double-blinded, controlled clinical effectiveness trial of
      two supplementary foods in the treatment of MAM. The setting will be 21 rural sites in
      southern Malawi. The participants will be 1800 children 6-59 months old with MAM, defined as
      mid-upper arm circumference (MUAC) ≥ 11.5 cm and < 12.5 cm and/or a weight-for-height Z-score
      (WHZ) between -2 and -3 without bipedal edema. Children will receive approximately 75
      kcal/kg/d (314 kJ/kg/d) of one of two RUSFs in two-week rations for outpatient therapy of
      MAM. The two supplements will be a novel, locally produced peanut/dairy RUSFs, one with a
      high protein quality (HIPRO RUSF) or one with a standard protein quality, referred to as
      control RUSF (C-RUSF). The primary outcome measures will be recovery from MAM (achieving MUAC
      ≥ 12.5 cm and/or WHZ>-2 by 12 weeks) or failure (death, development of severe acute
      malnutrition, transfer to hospital for inpatient care, failure to recover from MAM by 12
      weeks, default). Secondary outcome measures include rates of weight, height, and
      mid-upper-arm circumference (MUAC) gain, time to graduation, and adverse effects from the
      supplementary foods.
    


Intervention name(s): C-RUSF; HIPRO RUSF
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): -RUSF contains whey permeate, WPC 80, peanut paste, sugar, soy oil, canola oil, a customized micronutrient premix to account for the minerals in whey permeate, and an emulsifier; HIPRO RUSF contains extruded soy flour, skimmed milk, peanut paste, sugar, soy oil, palm oil, a premix containing concentrated minerals and vitamins, an emulsifier and dicalcium phosphate or calcium carbonate
Other intervention name(s): Ready-to-use supplementary food; Ready-to-use supplementary food
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Moderate Acute Malnutrition, Malnutrition
A Study in Healthy Adult Participants to Assess the Effects of Ciclosporin Administration on Rilematovir
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the pharmacokinetic (PK) of a single-dose of
      rilematovir co-administered with a single-dose of ciclosporin compared to a single-dose
      administration of rilematovir alone.
    


Intervention name(s): Rilematovir; Ciclosporin
Intervention type(s): Drug; Drug
Intervention description(s): Rilematovir will be administered orally as per assigned treatment sequence.; Ciclosporin will be administered orally as per assigned treatment sequence.
Other intervention name(s): JNJ-53718678
Intervention MeSH terms: Cyclosporine; Cyclosporins
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Sex and Female Empowerment
Condition: Opioid Use Disorder
MeSH terms: Opioid-Related Disorders
Study type: Interventional

Summary: 
      This study will develop and initially evaluate Sex and Female Empowerment (SAFE), an
      intervention designed to increase acceptance of and adherence to contraceptive practices
      among opioid-agonist-maintained women of childbearing age. The intervention will be delivered
      in one of two formats: a face-to-face brief intervention approach or a novel
      computer-adaptive platform. To the extent that either version of SAFE is found to be
      efficacious compared with usual care, it has the potential to reduce the number of unintended
      pregnancies and consequently decrease the need for and the costs of child protective
      services.
    


Intervention name(s): Computer-adaptive SAFE; Face-to-face SAFE; Usual Care
Intervention type(s): Behavioral; Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Pregnancy; Contraceptive Methods; Family Planning Services
A/H5N1/LT Dose Ranging Study
Condition: Pandemic Influenza
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a Phase 2, randomized, blinded, clinical trial. Up to 500 eligible subjects will be
      enrolled and randomized in a 1:2:2:1:2:2 ratio into one of six groups, and vaccinated in this
      study. Subjects will receive an intramuscular injection of the influenza A/H5N1 (low or high
      dose) on Day 0 with or without a patch (low or high dose).
    


Intervention name(s): A/H5N1; A/H5N1; LT Adjuvant Patch; LT Adjuvant Patch
Intervention type(s): Biological; Biological; Biological; Biological
Intervention description(s): A/H5N1 Low Dose; A/H5N1 High Dose; LT Adjuvant Patch Low Dose; LT Adjuvant Patch High Dose
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Brexpiprazole for the Treatment of Patients With Agitation Associated With Dementia of the Alzheimer's Type
Condition: Agitation Associated With Dementia of the Alzheimer's Type
MeSH terms: Dementia; Alzheimer Disease; Psychomotor Agitation
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      To evaluate the superiority of brexpiprazole 1 mg or 2 mg over placebo after a 10-week
      treatment regimen for agitation associated with dementia of the Alzheimer's type in patients
      who require medication, and to investigate the safety of brexpiprazole and identify the
      optimum dose.
    


Intervention name(s): Brexpiprazole; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Drug: 1 tablet /day Once daily for 10 weeks; Placebo: 1 tablet /day Once daily for 10 weeks
Intervention MeSH terms: Brexpiprazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Avon Foundation Program to Improve Quality of Life in Breast Cancer Survivors
Condition: Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Interventional

Summary: 
      Women with breast cancer often suffer significant distress and disability from their disease.
      A practice of meditation-based stress reduction and cognitive-affective-behavioral learning
      may help women with breast cancer decrease their suffering and improve their quality of life.
    

Detailed description: 
      The objective of this study in women recently treated for breast cancer is to determine
      whether an intervention program consisting of group and individual instruction in a
      meditation-based practice of stress-reduction and cognitive-affective-behavioral learning has
      the potential for reducing disabling distress and improving quality of life in a population
      vulnerable to the progression or recurrence of disease. Quality of life will be assessed at
      12 months.
    

Intervention name(s): Mindfulness based meditation program
Intervention type(s): Behavioral
Intervention description(s): Subjects will participate in an intervention consisting of group and individual instruction in a meditation-based practice of stress-reduction and cognitive-affective-behavioral learning.
Other intervention name(s): Meditation and Breast Cancer
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Meditation; Stress-reduction; Cognitive-affective behavior learning
Deep rTMS for Treatment-Resistant Late-life Depression
Condition: Major Depressive Disorder
MeSH terms: Depression; Depressive Disorder; Depressive Disorder, Major
Study type: Interventional

Summary: 
      In this study, the investigators will be examining the effects of the deep repetitive
      transcranial magnetic stimulation (rTMS) using the H1 coil in patients over the age of 60 who
      have been unable to tolerate or failed to respond to antidepressant medications. The coil was
      designed to stimulate deeper regions of the left DLPFC. The investigators propose that active
      stimulation with the H1 coil will result in higher remission rates than placebo stimulation
      but will have a similar tolerability and safety profile.
    

Detailed description: 
      This study is a randomized double blind, sham controlled study to evaluate the safety and
      efficacy of H1-coil rTMS as a treatment for patients over 60 years of age with major
      depressive disorder who have not tolerated or failed to respond to antidepressant
      medications. The study duration is 4-6 weeks in length. The acute phase is 4 weeks of 5 daily
      treatments followed by 2 weeks of biweekly treatment if remission is achieved at the 4 week
      mark. Symptom change and remission criteria will be assessed using the HRDS-24 item.
      Cognition will be assessed using a validated battery.
    

Intervention name(s): Brainsway H1-Coil Deep TMS System (Sham treatment); Brainsway H1-Coil Deep TMS System
Intervention type(s): Device; Device
Intervention description(s): In the sham treatment,the electrical field induced by the sham coil cannot invoke any action potentials and if no action potentials are induced, then the electric field is insignificant and there is no treatment effect on the brain.; Deep Transcranial Magnetic Stimulation (DTMS) is a new form of TMS which allows direct stimulation of deeper neuronal pathways than the standard TMS. The H-coil is a novel DTMS coil designed to allow deeper brain stimulation without a significant increase of electric fields induced in superficial cortical regions
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: rTMS; depression; magnetic
Protocol PERCAF 2018
Condition: Sleep; Caffeine; Polymorphism
MeSH terms: Sleep Deprivation
Study type: Interventional

Summary: 
      In this multicentric controlled study, we aims to evaluate effect of caffeine on mental
      performances during a sleep deprivation protocol. Genetic polymorphisms are considered as a
      covariable.
    

Detailed description: 
      Coffee is the most consumed arousing substance in the world. Caffeine is used as a natural
      countermeasure to maintain the performance of sleep deprived subjects. However, the
      effectiveness of caffeine is characterized by a large individual variability, also observed
      on side effects. This variability could notably be related to polymorphisms of the adenosine
      receptor 2a gene (ADORA2A) and Tumor Necrosis Factor-alpha, a pro-inflammatory cytokine whose
      increase is observed during sleep deprivation.

      This study, under conditions of total sleep deprivation in the laboratory (40 hours of
      continuous awakening), examine the cross-influence of two polymorphisms (ADORA2A: rs5751876
      and TNF-alpha: rs1800629) on the sensitivity to caffeine and on the degradation of
      attentional performances. Physical performance, mental performance, immuno-inflammatory
      responses and the occurrence indesirable effects will be evaluate.

      This work aims to understand the mechanisms that contribute to increasing individual
      vulnerability and promoting protective countermeasures. The purpose of this project is to
      improve the recommendations concerning the daily use of caffeine and during periods of
      prolonged awakening, particularly in the military environment.
    

Intervention name(s): Sleep deprivation
Intervention type(s): Other
Intervention description(s): 40 hours of continuous awaking in the sleep laboratory in order to compare before and after sleep deprivation for each treatment (Caffeine vs. placebo).
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: sleep deprivation; cognition; attention
A Study to Evaluate Oral Salmon Calcitonin in the Treatment of Osteoporosis in Postmenopausal Women Taking Calcium and Vitamin D
Condition: Osteoporosis
MeSH terms: Osteoporosis
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this Phase III study is to evaluate the efficacy and safety of oral salmon
      calcitonin in the treatment of patients with osteoporosis
    


Intervention name(s): SMC021 Oral calcitonin; SMC021 Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 0.8mg SMC021 - oral calcitonin, once daily; SMC021 - Placebo, once daily
Intervention MeSH terms: Calcitonin; Salmon calcitonin; Calcitonin Gene-Related Peptide; Katacalcin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Osteoporosis, oral salmon calcitonin, treatment, efficacy, tolerability
Local and General Immune Response After Coronavirus Disease (COVID-19) Vaccination in Volunteers
Condition: Covid19
MeSH terms: COVID-19
Study type: Interventional

Summary: 
      This study aims to gain more insight in the immunological characteristics and immune response
      on a local level (the nose) and systemic level (the blood) of healthy people vaccinated with
      the current available COVID-19 messenger ribonucleic acid (mRNA; BNT162b2) and viral vector
      based (ChAdOx1) vaccines.
    

Detailed description: 
      The immunological assays that will be performed on blood include immunophenotyping, serologic
      testing and cytokine analysis. Deep characterization of patients' immune profile offers a
      unique opportunity for comprehensive understanding of the mechanisms behind severe acute
      respiratory syndrome coronavirus 2 (SARS-CoV2) vaccination. The investigators will study
      immunological functions on the level of both adaptive and innate immunity by performing
      extensive immunophenotyping, cytokine analysis and RNA sequencing analysis. Biomarker
      analysis will be performed on protein and on RNA single cell level. Infectivity of different
      cell types including macrophages will performed. These analyses will be performed at the
      Human Immunodeficiency Virus (HIV) Cure Research Center (HCRC) laboratory.

      Nasal fluid: The investigators will compare the immune response and immunoglobulin production
      in nasal secretions before and after SARS-CoV2 vaccination. The investigators aim to compare
      the local versus the systemic (blood/serum) response to SARS-CoV2 vaccination. Further,
      patients that had a proven SARS-CoV2 infection will be compared with patients that never had
      COVID-19 symptoms nor antibodies.

      Questionnaire: a questionnaire will be filled in by the individual to assess if the
      individual went through a previous SARS-CoV2 infection and experienced symptoms post
      vaccination. The questionnaires are available as supplementary documents.
    

Intervention name(s): Blood and nasal fluid sampling before and after COVID-19 vaccination
Intervention type(s): Procedure
Intervention description(s): Blood and nasal fluid sampling take place just before the first COVID-19 vaccination and at 14-30 days after the second dose with the same vaccine. Sampling will be repeated at 6 months after the second vaccination, at 14-30 days after the third vaccination and at 6 months after the third vaccination. At all moments, a questionnaire is filled in.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: serum; nasal secretions; immune response