Body Composition After Laparoscopic Gastrectomy for Gastric Cancer
Condition: Gastric Cancer; Benign Gastric Tumor
MeSH terms: Stomach Neoplasms
Study type: Interventional

Summary: 
      Nutritional status including changes of body composition is one of the most important
      clinical determinants of outcome after gastrectomy for gastric cancer. Various type of
      gastric operations are widely used with favorable outcome in South Korea. It was reported
      that several advantages of laparoscopic gastrectomy are the prevention of overt weight loss
      and enhanced recovery of muscle mass at 6 months after surgery. But there have been no
      longitudinal studies evaluating changes in the body composition according to the different
      type of anastomosis of laparoscopic gastrectomy.

      The purpose of this prospective study was to investigate changes in lipid indices associated
      with whole body composition during 1 year of follow-up after laparoscopic gastrectomy.
      Gastrectomy resulted in improved lipid indices and a reduction in body weight, fat and LBM.
      The HDL-Csignificantly increased in the non-obese group for 1 year after gastrectomy and the
      reduction of TG level was positively correlated with fat, especially with trunk fat.
    

Detailed description: 
      -  All patients will undergo a laparoscopic gastrectomy for their gastric cancer (proved to
           be stage I or II) or benign gastric neoplasm by preoperative screening diagnostic
           procedure. They will receive laparoscopic gastrectomy as follows: (1) wedge resection,
           subtotal or total gastrectomy with or without lymph node dissection; (2) R0 resection;
           (3) laparoscopic gastrectomy; (4 gastroduodenal anastomosis or duodenal bypass,
           including Roux-en-Y or gastrojejunostomy.

        -  Pre-operative, 6 and 12 months post-operative body composition measurement will be
           performed on each patient. The whole body composition measurement will be assessed by
           Hologic 4500/A dual energy X-ray absorptiometry system. The software performs
           calculations of the differential attenuations of the two photon energies and present
           data of percentage of fat, fat mass (g), lean mass (g), bone mineral content (g), bone
           mineral density (g/cm2), and total mass (g).

        -  Laboratory analysis - There is a battery of labs that are ordered in both the
           pre-operative, 6 and 12 months post-operative time frame. These labs are ordered
           independent of the patient's participation in the study. These labs are ordered to
           evaluate and to assist management of the patient's medical comorbidities as well as to
           assess for adequate nutritional intake and balance.

        -  Queries on nutritional intake and exercise will be made at each post-operative
           appointment.
    

Intervention name(s): Laparoscopic gastrectomy
Intervention type(s): Procedure
Intervention description(s): (1) Wedge resection, subtotal or total gastrectomy with or without lymph node dissection; (2) R0 resection; (3) Laparoscopic gastrectomy; (4) Gastroduodenal anastomosis or duodenal bypass, including Roux-en-Y or gastrojejunostomy
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Body composition measurement; Lipid profile; Weight loss; Gastrectomy