Health of IVF Versus IVM Children (FM-BABIES)
Condition: Infertility; IVF; IVM
MeSH terms: Infertility
Study type: Observational

Summary: 
      The investigators conduct a follow up of our randomized controlled trial (RCT) to investigate
      the development of children born from In-vitro fertilization (IVF) and In-vitro maturation
      (IVM), in order to give strong evidence about the safety of IVM in women with high antral
      follicle count or especially polycystic ovary syndrome (PCOS).
    

Detailed description: 
      Since the birth of the first baby born from in-vitro maturation (IVM) in 1991, this technique
      has been considered an alternative solution for treating infertility beside conventional
      controlled ovarian stimulation for in-vitro fertilization (IVF). Since then, there are
      already more than 5000 children born from IVM, and that number is on the trend of increasing.

      Regarding technique, immature oocytes (germinal vesicle - GV) were aspirated from secondary
      follicles sized from 2-10mm, under follicle-stimulating hormone (FSH) priming or no ovarian
      stimulation at all. Afterward, the maturation process was undertaken in an artificial medium,
      out of a living body. This technique, by reducing the usage of external hormones, is highly
      effective in minimizing the risk of ovarian hyperstimulation syndrome (OHSS) in women with
      high antral follicle count, especially polycystic ovarian syndrome, with a rate of OHSS
      recorded as low as 0 percent. Alongside that, the pregnancy rate, as well as the live birth
      rate of IVM, when proceeded well, is not lower than conventional IVF. Until now, there is
      only one randomized controlled trial comparing these two techniques directly.

      Due to differences in the process of culturing between IVM and IVF, primarily the maturation
      is undertaken in an artificial medium, the health of children born from IVM received many
      interests. Numerous studies have been conducted to compare the development of children born
      from IVM and IVF. Neonatal outcomes of children born from IVM and IVF are considerably
      comparable. And the development of children born from these two techniques is not
      significantly different. All the information, as mentioned above, was not from randomized
      controlled trials but retrospective or prospective cohort studies. Thus, we conduct a follow
      up of our RCT to investigate the development of children born from IVM and IVM, to give
      strong evidence about the safety of IVM in women with high antral follicle count or
      especially PCOS.
    

Intervention name(s): Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3; Physical development and General Health; Developmental Red flags
Intervention type(s): Diagnostic Test; Other; Diagnostic Test
Intervention description(s): Ages & Stages Questionnaires®, Third Edition (ASQ®-3) is a developmental screening tool designed for use by early educators and health care professionals. It relies on parents as experts, is easy-to-use, family-friendly and creates the snapshot needed to catch delays and celebrate milestones.; Physical development and General health examination; Developmental Red flags Questionnaires
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Live babies born following the IVF and IVM from our FM study (NCT03405701)
      
Keywords: IVF; IVM; ASQ-3; Health of children