Effect of Electrostimulation on Glucose Profile of Patients With Type 2 Diabetes
Condition: Type 2 Diabetes; Physical Activity
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      Prevalence of type 2 diabetes (T2D) is increasing worldwide. Lifestyle remains the
      cornerstone treatment for patients with T2D who are often overweight and sedentary.

      Physical activity improves glucose metabolism of patients with T2D : increased glucose
      utilization during acute muscle activity and improved insulin sensitivity after regular
      training. The molecular mechanism underlying the effects of exercise on glucose metabolism
      involves the glucose transporter GLUT-4 which is regulated by physical activity.

      Several studies and meta-analysis have showed that physical activity reduces HbA1c by 0.6% on
      average. In addition, other data suggest a decrease in cardiovascular morbidity and mortality
      through physical activity.

      Recent recommendations for T2D management call for the practice of a structured type of
      endurance 150 minutes per week and muscle building 2 times per week. However, implementation
      of these recommendations is low, even when integrated into a therapeutic education program.
      Adherence is often transient and / or partial. In addition, many T2D subjects are unable to
      initiate a physical activity because of disabling complications or comorbidities or because
      of a major cardiorespiratory deconditioning.

      Neuro-myo electrical stimulation (NMES) is a physical treatment routinely used in functional
      rehabilitation to improve muscle strength and volume. The metabolic effect of NMES has been
      little studied. A pilot study conducted by our team on a population of 18 subjects with T2D
      showed that a week of daily NMES sessions significantly improved insulin sensitivity of about
      25% and up to 50 % for good responders. This result contrasted with the low induced energy
      expenditure by each 20-minute session of bi-quadricipital NMES, suggesting the possibility of
      a humoral or neural mechanism associated with NMES.

      To complete this work, we plan a randomized cross-over trial with 3 periods (6 weeks without
      NMES (control), 6 weeks with 3 sessions of NMES per week and 6 weeks with 5 sessions of NMES
      per week) to assess the glucose profile of sedentary T2D subjects during these different
      periods. We hypothesize that the bi-quadricipital NMES could improve glycemic control in T2D
      subjects and thus represent an alternative to traditional physical activity.
    


Intervention name(s): electrostimulation (with Compex® Compex2* (DJO, Vista, CA, USA)) 3 days per week .; electrostimulation (with Compex® Compex2* (DJO, Vista, CA, USA)) 5 days per week
Intervention type(s): Device; Device
Intervention description(s): outpatient biquadricipital electrostimulation 3 days per week with an electrostimulator Compex2* (DJO, Vista, CA, USA); outpatient biquadricipital electrostimulation 5 days per week with an electrostimulator Compex2* (DJO, Vista, CA, USA)
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: glucose profile; continuous glucose monitoring; electrostimulation