bioihbjkbjnl/mcl2 huggingface dataset:
Universal Screening for Tuberculosis and Anemia With the CHICA System
Condition: Tuberculosis; Iron Deficiency Anemia
MeSH terms: Tuberculosis; Anemia; Anemia, Iron-Deficiency; Iron Deficiencies
Study type: Interventional

Summary: 
      The CHICA system is a clinical decision support system that uses adaptive turnaround
      documents to provide point-of-care information to clinicians. The investigators will be
      studying whether it can help in the diagnosis and treatment of tuberculosis and iron
      deficiency anemia.
    

Detailed description: 
      The CHICA system is a clinical decision support system that uses adaptive turnaround
      documents to provide point-of-care information to clinicians. We will be studying whether it
      can help in the diagnosis and treatment of tuberculosis and iron deficiency anemia.
    

Intervention name(s): CHICA Diagnosis Module; CHICA Placebo
Intervention type(s): Other; Other
Intervention description(s): The CHICA module helped to screen and diagnose patients with tuberculosis or iron deficiency anemia; This was CHICA without the screening module
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Diagnostic
Keywords: CHICA; clinical decision support
Synbiotic Dietary Supplement and Gut Microbiota
Condition: Healthy
Study type: Observational

Summary: 
      To test the feasibility and safety of our designer synbiotic on gastrointestinal symptoms and
      gut microbiota and fecal metabolomics.
    

Detailed description: 
      This will be a double-blinded, randomized, placebo-controlled paired crossover pilot study in
      healthy controls aimed to evaluate gastrointestinal tolerance of a synbiotic dietary
      supplement.
    

Intervention name(s): Synbiotic
Intervention type(s): Dietary Supplement
Intervention description(s): Synbiotic dietary supplement in capsule form
Observational model: Case-Crossover
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Thirty two healthy volunteers, aged 18-45 years old, will be recruited for this pilot
        study, plan to enroll 16 subjects with a BMI 19-25 kg/m2 and 16 subjects with a BMI 30-35
        kg/m2.
Ventrointermediate Nucleus (VIM DBS) and Working Memory
Condition: Essential Tremor
MeSH terms: Tremor; Essential Tremor
Study type: Observational

Summary: 
      This is part of a larger study for which participants have already completed memory and
      thinking tests. In this study, investigators are trying to learn how deep-brain stimulation
      affects memory skills in essential tremor (ET) patients. We are especially trying to figure
      out how stimulation on each side of the brain may affect working memory.
    


Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Washington University School of Medicine Movement Disorder Clinic
      
Keywords: Essential Tremor
Nanosilver Fluoride to Prevent Dental Biofilms Growth
Condition: Dental Caries
MeSH terms: Dental Caries
Study type: Interventional
Phase: Phase 1

Summary: 
      This study aims to evaluate the effectiveness of nanosilver fluoride for controlling the
      growth of S. mutans present in dental plaque of children.
    

Detailed description: 
      The product will be apllied on cervical vestibular surfaces of incisors and canines healthy,
      with a total of 8 teeth, 4 upper and 4 below. Children will be instructed not to ingest any
      liquid or food within two hours after application. After a period of 7 days will be carried
      biofilm colect of cervical dental surfaces of incisors and / or canines upper and lower, with
      the aid of sterile spatulas. This material will be packaged in pre-weighed microfuge tubes
      containing 1.5 ml of buffered saline solution (0.9% sodium chloride), and transported under
      refrigeration immediately to the laboratory where analysis will be performed and the S.
      mutans colonies will be counted. The biofilm collect and posterior laboratorial analysis will
      be performed weekly.
    

Intervention name(s): nanosilver fluoride
Intervention type(s): Drug
Intervention description(s): The product will be applied in the volunteers in the morning, before the first class, in relative isolation, made with cotton rolls and Vaseline to protect the soft tissue. It will apply 30mg of the product with microbrush, previously standardized in a pilot study on cervical vestibular surfaces of incisors and canines healthy, on a total of 8 teeth, 4 upper and 4 lower. After a period of 7 days,the cervical dental biofilms will be collect, third on the buccal surfaces of incisors and / or canines upper and lower, with the aid of sterile spatulas.
Other intervention name(s): silver nanoparticles
Intervention MeSH terms: Fluorides
Intervention model: Single Group Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: silver nanoparticles; antimicrobial activity; toxicity; biofilm; cariostatic agents
The Efficacy of Ultrasound-guided Hydrodilatation With Hyaluronic Acid for Patients With Adhesive Capsulitis
Condition: Adhesive Capsulitis
MeSH terms: Bursitis
Study type: Interventional

Summary: 
      This study was conducted to compare the efficacy of hydrodilatation with hyaluronic acid
      under ultrasonographic guidance plus physical therapy (PT) with that of PT alone for treating
      adhesive capsulitis.
    

Detailed description: 
      Adhesive capsulitis is a common cause of shoulder pain, and the efficacy of most
      interventions is limited. This study was conducted to compare the efficacy of hydrodilatation
      with hyaluronic acid under ultrasonographic guidance plus physical therapy (PT) with that of
      PT alone for treating adhesive capsulitis.

      Design: a prospective, single-blinded, randomized, clinical trial

      Patient and methods:

      Patients with adhesive capsulitis for at least 3 months were enrolled and randomly allocated
      into group 1 (hydrodilatation with hyaluronic acid under ultrasonographic guidance plus PT)
      and group 2 (PT alone). The patients were evaluated before treatment and were reevaluated 0,
      6, and 12 weeks after the beginning of the treatment. Outcomes measures included a pain scale
      (visual analog scale), range of motion, Constant shoulder score, Shoulder Pain And Disability
      Index, and the Short Form-36
    

Intervention name(s): hyaluronic acid (hyruan); physical therapy
Intervention type(s): Drug; Other
Intervention description(s): 2cc hyaluronic acid; patient received traditional physical therapy, including therapeutic exercise and stretch exercise
Other intervention name(s): hyaluronate; rehabilitation
Intervention MeSH terms: Hyaluronic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: adhesive capsulitis; hyaluronic acid
Evaluation of the Sandblasting on the Rebonding Strength
Condition: Orthodontic Appliance Complication
Study type: Interventional

Summary: 
      Patients at the Orthodontic Department of University of Aleppo Dental School will be selected
      if they meet the inclusion criteria then fixed orthodontic treatment with 0.018-inch slot MBT
      appliances will be applied for those patients.

      The aim of this study is to compare Two rebonding procedures by applying a split-mouth
      design. The clinical failure rates of the two rebonding procedures will be evaluated.
    

Detailed description: 
      The sample of this study will be chosen after examination of patients referred to the
      Department of Orthodontics at the University of Aleppo Dental School then subjects who meet
      the inclusion criteria will be included in this trial.

      An information sheet will be given to each possible candidate. Then consent forms will be
      obtained.

      All patients will receive both rebonding procedures by applying split-mouth design. Each
      patient will be asked to select an opaque sealed envelope from a box with 20 ones. Ten
      envelopes will Include instructions for applying sandblasting prior to acid-etching on the
      right upper premolars and acid-etching alone on the left upper premolars. In contrast, the
      other ten envelopes will include opposite instructions.

      A total sample of 80 premolars will be obtained to study the clinical failure rates of the
      two rebonding procedures.

      The 80 premolars will be randomly divided into two groups:

        -  The first group in which the enamel will be prepared using sandblasting prior to
           acid-etching.

        -  The second group in which the enamel will be prepared using acid-etching alone.
    

Intervention name(s): Sandblasting; Acid Etching
Intervention type(s): Procedure; Procedure
Intervention description(s): Sandblasting will be applied onto the vestibular surfaces of the teeth before applying the etchant.; Only acid etching will be applied onto the vestibular surfaces of the teeth before rebonding
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Split-mouth design
Masking: Single (Participant)
Primary purpose: Other
Characterizations of Gut Microbiota and Postoperative Sleep in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass
Condition: Heart Valve Surgery
Study type: Observational

Summary: 
      The investigators designed a study to assess whether there is any change in gut microbiota
      and postoperative sleep before and after heart valve surgery with cardiopulmonary bypass.
    

Detailed description: 
      The investigators designed a study to assess whether there is any change in gut microbiota
      and postoperative sleep before and after heart valve surgery with cardiopulmonary bypass.
      Firstly, this study aims to characterize the gut microbiota in patients with valve disease
      treated with surgery. Secondly, it aims to evaluate microbiota and its influence on
      postoperative sleep.
    

Intervention name(s): polysomnography
Intervention type(s): Device
Intervention description(s): Duration of sleep was collected with polysomnography on second postoperative night. (from 20:00pm to 06:00am).
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        This study will characterize the gut microbiota and serum metabolites in one group of 36
        patients before and after heart valve surgery
      
Biospecimen description: 
      gut microbiota and serum
    
Keywords: Gut Microbiota; polysomnography
2-Part Multiple Ascending Dose Study for Safety and Pharmacokinetics in Healthy and Elderly Subjects
Condition: CNS
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a single-center, randomized, double-blind, placebo-controlled, sequential,
      multiple-dose study. The study will be conducted in two parts: Part A (6 cohorts of healthy
      adults receiving evening dosing) and Part B (one cohort of elderly adults receiving evening
      dosing).
    


Intervention name(s): E2006; Placebo comparator
Intervention type(s): Drug; Drug
Intervention description(s): Part A: 2.5 mg, 5 mg, 10 mg, 25 mg, 50 mg, and 75 mg E2006 administered as capsules; E2006-matched placebo (Part A and Part B); Part B: dose level to be determined based on results of Part A, administered as capsules
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: insomnia
Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility
Condition: Infertility, Male
MeSH terms: Infertility; Infertility, Male
Study type: Observational

Summary: 
      Men are recruited to collect seminal plasma samples and serum samples from men with
      azoospermia, men receiving medical treatment of infertility and men attending semen analysis.
      MicroRNA (miRNA) and PiWi-interacting RNA (piRNA) are analyzed for all of the groups to find
      potential differences. Steroid hormones are analyzed by liquid chromatography-tandem mass
      spectrometry.
    

Detailed description: 
      Azoospermic men attending microdissection testicular sperm extraction (MD-TESE) are group A.
      Second group (B) is the men with poor semen quality, who are treated with aromatase
      inhibitor, antiestrogen or human choriogonadotropic hormone (HCG) to improve semen quality.
      Third group (C) consists of men submitting semen analysis. The intended number of
      participants is 60, 60 and 100 men, respectively.

      Seminal plasma and serum samples are collected and miRNA and piRNA are analyzed. Steroid
      hormones are analyzed by liquid chromatography-tandem mass spectrometry. The participants are
      given a physical examination and testicular ultrasound. The primary aim of this study is to
      develop a tool to better estimate the sperm recovery rate (SRR) of azoospermic men scheduled
      for MD-TESE. Since no data have been published presenting miRNA and piRNA levels in men with
      normal semen, a secondary aim is to describe the levels of miRNA and piRNA in unselected men.
      Third part of this study aims to find if medical treatment improving semen parameters affects
      miRNA ja piRNA findings.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Men contacting the fertility clinic in Turku University Hospital
      
Biospecimen description: 
      Semen sample Serum sample
    
Keywords: azoospermia; male fertility; MD-TESE; miRNA; piRNA; male infertility
Polycystic Ovary Syndrome and Liraglutide
Condition: PCOS; Obesity
MeSH terms: Polycystic Ovary Syndrome
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study was to determine whether liraglutide is more effective than
      metformin in the treatment of obese women with newly diagnosed polycystic ovary syndrome
      (PCOS). We anticipated greater changes in body weight in patients treated with liraglutide
      than in those treated with metformin.
    


Intervention name(s): liraglutide; metformin
Intervention type(s): Drug; Drug
Other intervention name(s): Victoza 6 mg/ml solution for injection in pre-filled pen; Glucophage tablets
Intervention MeSH terms: Metformin; Liraglutide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: PCOS; obesity; GLP-1 receptor agonist; liraglutide; metformin
A Phase 1 Study to Examine the Pharmacodynamics of Different AZD1722 Formulations
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The study is designed to evaluate safety, tolerability, pharmacodynamics and pharmacokinetics
      of different formulations of AZD1722 in healthy male and female subjects taking Omeprazole.
    


Intervention name(s): AZD1722; Omeprazole
Intervention type(s): Drug; Drug
Other intervention name(s): Tenapanor; RDX5791
Intervention MeSH terms: Omeprazole
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Volunteers
Study of Aldafermin (NGM282) in Participants With Impaired Hepatic Function
Condition: Impaired Hepatic Function
Study type: Interventional
Phase: Phase 1

Summary: 
      This is an evaluation of Aldafermin (NGM282) in an open-label, single-dose and parallel group
      study in participants with Impaired Hepatic Function
    


Intervention name(s): Aldafermin
Intervention type(s): Biological
Intervention description(s): Biological: Aldafermin (NGM282) Subcutaneous Injection
Other intervention name(s): NGM282
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Leptin Levels in Papillary Thyroid Cancer
Condition: Thyroid Cancer, Papillary; Leptin Levels
MeSH terms: Thyroid Neoplasms; Thyroid Cancer, Papillary; Thyroid Diseases
Study type: Observational

Summary: 
      The purpose of this study is to evaluate Leptin levels in females, in the setting of
      papillary thyroid cancer, benign thyroid nodules, and in normal females without thyroid
      disease.
    

Detailed description: 
      There will be three groups in this study, but 2 of the groups are part of another study so
      will only recruit normal controls.
    

Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Females with no prior history of thyroid disease and not on thyroid medications.

        Active recruitment will be for normal controls only. They will be age and weight/height
        matched to females with prior diagnosis of thyroid cancer or thyroid nodules who are
        already part of another study.
Bioequivalency Study of Ramipril 10 mg Capsules Under Fasting Conditions
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      The objective of this study was to prove the bioequivalence of Ramipril 10 mg capsules under
      fasting conditions.
    


Intervention name(s): Ramipril
Intervention type(s): Drug
Intervention description(s): 10 mg capsule
Intervention MeSH terms: Ramipril
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Evaluation of Endoplasmic Reticulum Stress in Patients With Recurrent Pregnancy Loss
Condition: Recurrent Pregnancy Loss; Endoplasmic Reticulum Stress
MeSH terms: Abortion, Spontaneous; Fetal Death; Abortion, Habitual; Recurrence
Study type: Observational

Summary: 
      To evaluate endoplasmic reticulum stress in women with recurrent pregnancy loss and those who
      had healthy births in the same age group. The level of the unfolded protein X box binding
      protein 1 (XBP-1) is measured. It is aimed to show the effect of endoplasmic reticulum stress
      on recurrent pregnancy loss.
    


Intervention name(s): x box binding protein
Intervention type(s): Other
Intervention description(s): Serum value (pg / mL) of x box binding protein (XBP-1), which is one of the unfolded proteins indicating endoplasmic reticulum stress, is measured.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Loss of 3 or more pregnancy between the ages of 18 and 45 and women who have given at least
        1 healthy birth in the same age group.
A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophrenia (EMERGENT-3)
Condition: Schizophrenia; Schizophrenia; Psychosis
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a Phase 3, randomized, double-blind, parallel-group, placebo-controlled, multicenter
      inpatient study to examine the efficacy and safety of KarXT in adult subjects who are acutely
      psychotic with a Diagnostic and Statistical Manual Fifth Edition (DSM-5) diagnosis of
      schizophrenia. The primary objective of the study is to assess the efficacy of KarXT (a fixed
      combination of xanomeline 125 mg and trospium chloride 30 mg twice daily [BID]) versus
      placebo in reducing Positive and Negative Syndrome Scale (PANSS) total scores in adult
      inpatients with a DSM-5 diagnosis of schizophrenia. The secondary objectives of the study are
      to evaluate improvement in disease severity and symptoms, safety and tolerability, and
      pharmacokinetics in adult inpatients with a DSM-5 diagnosis of schizophrenia.
    


Intervention name(s): Xanomeline and Trospium Chloride Capsules; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Oral xanomeline 50 mg/trospium 20 mg BID on days 1-2 followed by xanomeline 100 mg/trospium 20 mg BID on days 3-7. The dose is increased to xanomeline 125 mg/trospium 30 mg BID on days 8-35 unless the subject is experiencing adverse events from the xanomeline 100 mg/ trospium 20 mg dose. Subjects who were increased to xanomeline 125 mg/trospium 30 mg will have the option to return to xanomeline 100 mg/ trospium 20 mg depending on clinical response and tolerability.; Placebo Capsules
Intervention MeSH terms: Xanomeline; Trospium chloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
The Pilot Study of High-throughput Sequencing in Neonatal Birth Defects
Condition: Birth Defect; Newborn; Fit; Genetic Diseases; Multiple Malformation; Congenital Malformation
MeSH terms: Congenital Abnormalities; Genetic Diseases, Inborn
Study type: Observational

Summary: 
      In China, birth defects can reach as high as 5.6%, about 900,000 new cases of birth defects
      are added each year, making it the second cause of death for infants, with a total death rate
      of 19.1%. At present, China implements the three-level prevention and control system for
      birth defects, which is performed before marriage, before birth, and during the neonatal
      period. Newborn screening is the last line of defense against birth defects. Early screening
      diagnosis and timely intervention are extremely important, especially for diseases which can
      be preventive and treatable. This study aims to evaluate the clinical application of
      high-throughput targeting sequencing in newborns, and investigate whether this new technology
      can significantly shorten the time of examination, improve the diagnosis rate, guide the
      intervention treatments and promote prognosis for these disease.
    


Intervention name(s): NGS panel
Intervention type(s): Diagnostic Test
Intervention description(s): A next-generation-sequencing panel, which contains a group of genes that specifically cause disease, for mutational analysis in newborns.
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Neonates in one of the study hospitals