bioihbjkbjnl/mcl2 huggingface dataset:
Utilized Scan Body Technique For Triple Function
Condition: Digital Technology; Dental Implant; Occlusion
Study type: Interventional

Summary: 
      A triple function scan Body were done on healed dental implant, thus simplifying the workflow
      for full arch cases and reducing the number of visits to only 3 visits. In this technique,
      scan bodies were utilized for implant position scanning, facial scan alignment and as
      stoppers for jaw relation capturing as scan bodies were used as stoppers for jaw relation
      registration.
    

Detailed description: 
      The present article describes a novel technique for merging a patient's facial scan with
      implant scan body and in the same time utilizing the same scan body for recording the jaw
      relation in only one visit. As a result, a facially driven full-arch implant-supported
      interim prosthesis can be fabricated first followed by the final restoration in a simplified
      approach. The aim of this study is to determine whether there is a difference between virtual
      design and reality using scan body technique (triple function scan body which reflects the
      accuracy of the scanning protocol. The null hypothesis established that there was consistency
      between the virtual design and prosthesis in patient's mouth. The scan body was placed in the
      edentulous arch in the jaw scan step so that bite registration would be easier for the
      intraoral scanner (IOS) in order to be able to capture both the teeth of the antagonist and
      part of the scan body in the edentulous jaw simultaneously.
    

Intervention name(s): Triple function scan body
Intervention type(s): Procedure
Intervention description(s): The scan bodies were used to scan the implant position, Jaw registration and facial scan alignment, First of all scan bodies were selected according to vertical dimension of occlusion, then the emergence profile together with the selected scan body were scanned,All scan bodies were then removed from the patient mouth except one or even two that were scanned in the jaw scan step, this scan body was utilized as a stopper, the patient was asked to bite until the scan body came in contact with the lower or upper teeth in case of edentulous upper or lower arch respectively, scan body in place (in the same orientation of the previous jaw scan ) provided that at least the tip of the scan body appeared when the patient is asked to smile which would be used as a common area so that the intra oral scanner can relate the jaw scan to the lips and face.
Intervention model: Single Group Assignment
Intervention model description: Triple Function Scan Body
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Jaw relation; Scan body; Full arch dental implants
Noninvasive Peripheral Nerve Stimulation for Medication-Refractory Primary RLS (The RESTFUL Study)
Condition: Restless Legs Syndrome
MeSH terms: Psychomotor Agitation; Restless Legs Syndrome; Syndrome
Study type: Interventional

Summary: 
      Multi-center, prospective double-blind randomized controlled pivotal study of noninvasive
      peripheral nerve stimulation (NPNS) with the NTX100 Neuromodulation System for patients with
      medication-refractory moderate-severe primary RLS
    

Detailed description: 
      The study consists of a series of two 4-week phases:

      Phase 1: Prospective, double-blinded, 1:1 randomized (Active treatment: Sham control)

      Phase 2: Prospective, non-randomized, non-blinded, Active treatment
    

Intervention name(s): NTX100 Neuromodulation System - Active; NTX100 Neuromodulation System - Sham; NTX100 Neuromodulation System - Open-Label
Intervention type(s): Device; Device; Device
Intervention description(s): Noninvasive peripheral nerve stimulation device programmed to active mode.; Noninvasive peripheral nerve stimulation device programmed to sham mode.; Noninvasive peripheral nerve stimulation device programmed to active mode.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Study consists of two phases. Phase 1: Randomized 1:1 between Active treatment and Sham control Phase 2: Non-randomized, Active treatment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
The First Jordanian PCI Registry: Events at 1 Year
Condition: Percutaneous Coronary Intervention
Study type: Observational [Patient Registry]

Summary: 
      The investigators will look at the short- (in hospital) and long- term ( 1 year)outcome in
      consecutive patients who undergo stent implantation and angioplasty in Jordan.
    

Detailed description: 
      1. Voluntary registry of consecutive patients undergoing Percutaneous coronary intervention
           (PCI).

        2. Patients will be treated according to the treating cardiologists' discretion. No
           randomization of any medication or stent.

        3. Baseline data on admission will be collected (cardiovascular risk factors, blood lipids,
           ect).

        4. PCI procedure details and complications will be documented during the index admission.

        5. Outcome events (death, MI, revascularization, stent thrombosis) will be evaluated at 1,
           6, and 12 months by clinic visits or phone calls.
    

Intervention name(s): Procedure: PCI
Intervention type(s): Procedure
Other intervention name(s): PCI (percutaneous coronary intervention)will be performed according to cardiologists discretion, with no randomization of stent types or medications.
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Consecutive patients with acute coronary syndrome and stable coronary syndromes undergoing
        PCI.
      
Keywords: Outcome after PCI; Middle Eastern Patients
The Long-term Impact of Invasive Meningococcal Disease in Australian Adolescents and Young Adults
Condition: Meningococcal Infections; Neisseria Meningitis Sepsis; Neisseria Infection
MeSH terms: Infections; Communicable Diseases; Meningococcal Infections; Meningitis
Study type: Observational

Summary: 
      Survivors of invasive meningococcal disease (IMD) experience a range of mild to severe
      sequelae that impact upon their quality of life. The majority of studies to date have focused
      on the impact of IMD on childhood and very little is known about the impact of the disease on
      adolescents and young people.

      The aim of this study is to assess the physical, neurocognitive, economic and societal impact
      of IMD on adolescents and young adult Australian survivors.

      Hypothesis:

        1. Adolescents and young adult survivors who are 2 to 10 years post IMD have significantly
           poorer outcomes including intellectual functioning and quality of life when compared to
           healthy controls.

        2. IMD imposes a significant financial burden upon individuals, families and society.

        3. Serogroup B disease is associated with an increased risk of sequelae when compared to
           non-B serogroup IMD.

      Study design:

      This a multi-centre, case-control mixed-methods study. Survivors of IMD (retrospective and
      prospective cases) and non-IMD healthy controls will be invited to participate in the study.

      Retrospective IMD cases admitted in the previous 10 years will be identified through each of
      the participating hospitals (paediatric and adult hospitals). During the course of the study
      prospective recruitment of IMD cases will also occur at participating hospitals.
      Meningococcal foundations/groups will also be approached and asked to advertise and conduct a
      mail out to their members to inform them about the study.

      Healthy controls will be prospectively recruited by "snowballing technique" whereby enrolled
      IMD cases will be asked to distribute a study information sheet to their healthy
      friends/acquaintances who are approximately the same age. Control participants may also be
      identified from databases at each participating site or through community advertising.

      Enrolled cases will undergo a neurocognitive, psychological and physical examination 2 - 10
      years post IMD admission. A subset of IMD cases will be invited to participate in a
      semi-structured interview. Controls will also undergo neurocognitive, psychological and
      physical examination.
    


Observational model: Case-Control
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        Population sample from participating Australian hospitals in Adelaide, Melbourne, Perth,
        and Sydney.
Inhaled TPI-1020 Versus Inhaled Budesonide in Smokers With Mild Reversible Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 2

Summary: 
      The investigators will look at TPI-1020 safety and tolerability in mild to moderate asthmatic
      smoker subjects.
    

Detailed description: 
      This study will assess and compare the safety and tolerability of inhaled TPI 1020 versus
      budesonide. Pharmacokinetic (PK) and pharmacodynamic (PD) parameters will also be studied in
      a sub-group of subjects.
    

Intervention name(s): TPI-1020; budesonide
Intervention type(s): Drug; Drug
Intervention description(s): 600 mcg BID x 14 days followed by 1200 mcg BID x 7 days; 400 mcg BID x 14 days then 800 mcg/day x 7 more days
Intervention MeSH terms: Budesonide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Smokers; Adults; Inflammatory markers
Feasibility Study of a Vaginal Ring for Delivery of TMC120 (Dapivirine)
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this trial was to evaluate the safety and feasibility of using a vaginal ring
      to deliver the candidate microbicide TMC120 (dapivirine). Twelve women initially underwent
      7-day exposure to a placebo ring containing no investigational agent. They then underwent
      7-day exposure to a ring containing 120 mg of TMC120 (dapivirine). Feasibility was assessed
      in terms of safety and tolerability as well as drug delivery.
    


Intervention name(s): placebo vaginal ring; TMC120 (dapivirine) vaginal ring
Intervention type(s): Drug; Drug
Intervention description(s): vaginal ring containing no TMC120 (dapivirine); vaginal ring containing 120 mg TMC120 (dapivirine)
Intervention MeSH terms: Dapivirine
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: HIV-I; Reverse transcriptase inhibitors; HIV Seronegativity
The Utility of Telemedicine in the Management of Migraine
Condition: Migraine Headaches
MeSH terms: Migraine Disorders; Headache
Study type: Observational

Summary: 
      Patients will be randomly assigned to receive their follow-up care via telemedicine or
      in-office visits.
    

Detailed description: 
      After obtaining informed consent, patients will be randomly assigned to receive their
      follow-up care via telemedicine or in-office visits. All subjects will complete a MIDAS
      questionnaire and allodynia questionnaire at their initial visit. Follow-up visits will be
      scheduled at 4-6 weeks, 3, 6, 9 and 12 months. In-person follow-up visits will be conducted
      in the standard fashion of the current physician's practice, with the initial intake
      conducted by an ophthalmic technician or resident, followed by the physician visit.
      Telemedicine visits will be conducted by the physician and recorded. Similar information will
      be gathered in both groups including: current medications, interim medical and headache
      history (including visits to the ED or hospitalizations for headache), description of
      headache, response to treatment (including adverse reactions), allergies, blood pressure and
      weight. Subjects randomized to telemedicine will be asked to have their blood pressure and
      weight measured within 5 days of their telemedicine session at a location convenient to them.
      We will record the length of each visit. Subjects in the in-person group, will be queried
      about travel time, and the total amount of time for the visit, and any activities missed to
      attend the visit. We will also ask about other costs associated with attending the office
      visit, such as child care.

      At the one-year follow-up visit, subjects will complete the MIDAS, allodynia questionnaire,
      Modified Group Health Association of America's Consumer Satisfaction scale, and have the
      opportunity to express their views on the aspect of care received in a semi-structured
      interview. The follow-up questionnaires may be completed on line (telemedicine group,
      optional for in-person group) or on paper (in-person group). Headache diaries will be
      provided on line or may be done on paper, a smartphone, or a computer program of the
      subject's choosing.

      All subjects will be able to access the physician by telephone, using MyChart, or with
      additional non-study visits as needed.

      Subjects will be responsible for the cost of the medications, treatments prescribed, and
      laboratory monitoring needed for their condition.

      Support staff will be available to help set up the video system for subjects assigned to the
      telemedicine group who are in need of assistance.
    

Observational model: Ecologic or Community
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients must be diagnosed with Migraine Headaches
      
Keywords: Migraine; Headaches; Telemedicine
Acute Cardiorespiratory Effects of E-cigarette Inhalation
Condition: Healthy
MeSH terms: Respiratory Aspiration
Study type: Interventional

Summary: 
      According to the World Health Organization cigarette smoking is today one of the leading
      single causes of preventable death and morbidity. The electronic cigarette (e-cigarette) has
      been marketed as a safer alternative to conventional cigarettes, and its global sales
      continue to grow exponentially each year. Despite growing e-cigarette use, scientific data on
      health effects are insufficient in some respects and completely lacking in others. Therefore
      the current study is designed to investigate the effects of active e-cigarette inhalation on
      the cardiovascular and respiratory systems.
    

Detailed description: 
      It is estimated that 6 million people worldwide lose their lives due to tobacco use yearly.
      On average, cigarette smokers are estimated to die 10 years earlier than non-smokers.
      Ischemic heart disease, chronic obstructive pulmonary disease, stroke, respiratory illness,
      lung cancer and other cancers have all been linked to tobacco use. In recent years the
      electronic cigarette (e-cigarette) has been introduced to the market as an alternative to
      traditional cigarette smoking. E-cigarettes have been aggressively marketed as a cheaper,
      healthier, cleaner alternative to smoking in both advertising and media outlets, primarily
      targeting women and adolescents. With limited knowledge of e-cigarette vaping health effects
      in humans it has been challenging for governments and health officials to give advice and
      regulate the use of this novel product.

      In the current study investigators aim to investigate acute cardiovascular and respiratory
      effects after active inhalation of e-cigarette in healthy human subjects.
    

Intervention name(s): E-cigarette
Intervention type(s): Other
Intervention description(s): A third generation e-cigarette device will be used with pre-determined temperature, voltage and wattage settings.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Nicotine; Electronic Cigarette
Oxymatrine Plus Lamivudine Combination Therapy Versus Lamivudine Monotherapy for Chronic Hepatitis B Infected Subjects
Condition: Chronic Hepatitis B
MeSH terms: Hepatitis A; Hepatitis B; Hepatitis B, Chronic; Hepatitis; Hepatitis, Chronic
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to evaluate the efficacy of Oxymatrine plus Lamivudine
      Combination Therapy and whether it could lower the incidence of Lamivudine long-term
      resistance compared to Lamivudine Monotherapy.
    

Detailed description: 
      Group A (Lamivudine Monotherapy): Lamivudine (Manufacturer: GlaxoSmithKline) 100mg po, qd.

      Group B (Oxymatrine + Lamivudine Combination Therapy): Lamivudine (Manufacturer:
      GlaxoSmithKline) 100mg po, qd; oxymatrine Capsules (Chia Tai Tianqing Pharmaceutical Group
      Co., Ltd) 200 mg, po, tid.

      Total subjects: 200, 100 patients randomized in each group.
    

Intervention name(s): Lamivudine; Lamivudine+Oxymatrine Capsules
Intervention type(s): Drug; Drug
Intervention MeSH terms: Lamivudine; Oxymatrine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Oxymatrine Capsules, lamivudine, chronic Hepatitis B
Effectiveness of Clozapine Versus Olanzapine for Treatment-resistant Schizophrenia
Condition: Schizophrenia
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 4

Summary: 
      This study will determine the effectiveness of clozapine versus olanzapine in treating people
      with schizophrenia that has not improved with treatment.
    

Detailed description: 
      This is a two-year open-label, randomized trial of the comparative effectiveness of clozapine
      versus olanzapine in patients with treatment refractory schizophrenia. The objective is to
      determine whether in a naturalistic setting olanzapine is a logical treatment choice (before
      using the more toxic clozapine) for some treatment refractory patients.
    

Intervention name(s): Clozapine; Olanzapine
Intervention type(s): Drug; Drug
Intervention MeSH terms: Olanzapine; Clozapine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Clozapine; olanzapine
Safety, Tolerability and Pharmacokinetics of Single Rising Oral Doses of BI 1060469 in Healthy Asian Male Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The objective of this single rising dose study (SRD) is to investigate safety, tolerability,
      and pharmacokinetics of single rising doses of BI 1060469 in healthy Asian male subjects.
    


Intervention name(s): BI 1060469; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): single rising doses given as tablet; given as tablet (matching placebo of BI 1060469)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Mesalazine Therapy in Patients With Irritable Bowel Syndrome
Condition: Irritable Bowel Syndrome
MeSH terms: Irritable Bowel Syndrome; Syndrome
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to determine whether Mesalazine is effective in the treatment of
      the abdominal discomfort or pain of Irritable Bowel Syndrome patients.
    

Detailed description: 
      The present study is a prospective, double blind, randomised, multicenter trial designed to
      study the efficacy of mesalazine treatment on symptoms of IBS. In a subgroup of patients the
      efficacy of this treatment will be also assessed on low-grade inflammation. We expect to
      confirm that mesalazine treatment reduces the number and activation of inflammatory cells in
      the colonic mucosa of IBS patients, thus providing the rationale for the assessment of this
      treatment on symptoms of IBS.
    

Intervention name(s): Mesalazine; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Mesalazine 800mg t.i.d. 12 weeks; Placebo cpr, t.i.d. 12 weeks
Other intervention name(s): Pentacol 800, Sofar
Intervention MeSH terms: Mesalamine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Mesalazine in Irritable Bowel Syndrome
Transcranial Magnetic Stimulation Effects on Nicotine Craving
Condition: Nicotine Dependence
MeSH terms: Tobacco Use Disorder
Study type: Interventional

Summary: 
      The proposed study will measure the change of cortical excitability during nicotine craving
      and examine the effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on nicotine
      craving and cue-reactivity among adult regular smokers.
    

Detailed description: 
      This pilot protocol proposes to test and further develop TMS for the purpose of studying
      brain function in nicotine users.

      Specific Primary Aims include:

      Aim # 1. To test change of cortical excitability during nicotine craving in cigarette smokers
      and explore the potential use of TMS in cigarette smokers.

      Aim # 2. Given the role of the prefrontal cortex (and connected regions) in craving, we will
      examine whether modulating prefrontal activity through rTMS will impact measures of craving
      and the reinforcing effects of nicotine.

      Design:

      The study was a randomized, blind, sham-controlled crossover study in which participants will
      involve two study visits. Participants will have an initial assessment about tobacco use
      habits and craving patterns. Participant will look at images related to and not related to
      cigarette smoking.

      Participants will receive two different types of brain stimulation with repetitive TMS (10
      Hz): sham rTMS and active rTMS over prefrontal cortex. Craving assessments will be performed
      before and after each stimulus experiment.

      Participants will be measured cortical excitability with TMS before and after each stimulus
      experiment.
    

Intervention name(s): Transcranial Magnetic Stimulation (Neuronetics); Sham Transcranial Magnetic Stimulation
Intervention type(s): Device; Device
Intervention description(s): Transcranial magnetic stimulation is a noninvasive brain stimulation that can focally stimulate the brain of an awake individual. A TMS pulse focally stimulates the cortex by depolarizing superficial neurons which induces electrical currents in the brain.; The electrical current of the sham system is titrated to a level matching participants' ratings of active TMS.The sham-TMS scalp discomfort will be matched to that of active TMS.
Other intervention name(s): Neuronetics® Model 3600; Transcutaneous Electrical Nerve Stimulation Device
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: nicotine; craving; smoking; TMS; prefrontal cortex
Abdominal Versus Vaginal Hysteropexy
Condition: Uterine Prolapse
MeSH terms: Uterine Prolapse; Prolapse
Study type: Interventional

Summary: 
      This study will compare the vaginal versus the abdominal approach for the management of
      uterine prolapse
    

Detailed description: 
      this study compares The unilateral sacrospinous hysteropexy with prolene sutures versus the
      abdominal sacral hysteropexy using Mersilene suture for the management of uterine prolapse
    

Intervention name(s): Sacral Hysteropexy; sacrospinous Hysteropexy
Intervention type(s): Procedure; Procedure
Intervention description(s): Abdominal approach for uterine suspension; Transvaginal approach for uterine suspension
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment