bioihbjkbjnl/mcl2 huggingface dataset:
Evaluation of Biocleanse Allografts For ACL Reconstruction
Condition: Anterior Cruciate Ligament Tear
MeSH terms: Anterior Cruciate Ligament Injuries
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to determine the efficacy of patellar tendon allografts that
      have undergone the BioCleanse™ process.
    

Detailed description: 
      The purpose of this study is to determine the efficacy of patellar tendon allografts that
      have undergone the BioCleanse™ process.

      You are being asked to volunteer in a research study. The purpose of this study is to compare
      the different ways of cleaning allograft tendons used to replace the main ligament in the
      knee. The anterior cruciate ligament (ACL) is the main ligament in the knee that your doctor
      will replace in your surgery. The allograft tendons come from other people who have donated a
      tendon from the front of the knee after they died.

      The three ways of cleaning the tendons that will be used in this study are BioCleanse,
      irradiation, and aseptic. Aseptic uses clean conditions when preparing the tissue for
      surgery, sometimes with a chemical bath. BioCleanse is a way of cleaning the tendon
      physically and chemically, while irradiation uses gamma rays. The goal is to clean the
      tendons to make them safer for the patients without weakening the tendon when put in the
      knee.
    

Intervention name(s): ACL reconstruction control; ACL Biocleanse, surgical
Intervention type(s): Procedure; Procedure
Intervention description(s): The intervention consists of the reconstruction of the ACL ligament using patellar tendon allografts that have undergone the BioCleanse™ process.; The intervention consists of the surgical reconstruction of the ACL ligament using patellar tendon allografts that have undergone the BioCleanse™ process.
Other intervention name(s): Standard ACL allograft; BioCleanse™ process
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Intraarterial Stem Cells in Subacute Ischemic Stroke
Condition: Ischemic Stroke; MCA Infarction
MeSH terms: Stroke; Ischemic Stroke; Cerebral Infarction; Infarction, Middle Cerebral Artery; Ischemia; Infarction
Study type: Interventional
Phase: Phase 1

Summary: 
      Stroke is a leading cause of morbidity and mortality.Acute ischemia causes irreversible
      damage to neurons and glial cells, leading to functional deficits and chronic sequelae with
      variable degrees of spontaneous recovery of function. Stem cells have been shown to enhance
      recovery through multiple immunomodulatory effects, neoangiogenesis and neurogenesis.

      We conducted a prospective randomised end observer blinded study to evaluate primarily the
      safety of intraarterial autologous stem cells delivered to ipsilateral middle cerebral artery
      in acute and subacute stroke patients (0-15 days post ictus).Secondarily we aimed to evaluate
      the outcome on the basis of clinical evaluation and follow up imaging
    

Detailed description: 
      1. This study was done over a period of one and a half years from July 2015 to December
           2016. A total of 229 patients who presented with acute middle cerebral artery stroke and
           admitted at Post graduate institute of medical education and research were evaluated for
           recruitment into this study.

        2. Participants who satisfied the inclusion criteria were randomized at 1 week into control
           and stem cell infusion test group within 15 days of stroke onset.

        3. Investigators evaluated 20 patients, with 10 each in control and stem cell infusion test
           group.

        4. Participants in the test group were infused autologous bone marrow mononuclear cells
           through intraarterial route using a microcatheter which was placed in proximal
           ipsilateral M1 segment of MCA. Participants in the control group did not receive stem
           cell therapy. Rest of the pharmacological treatment and physiotherapy were similar in
           both groups for the period of 6 months.

      5,Participants were evaluated with clinical and radiological follow up at 6 months.
    

Intervention name(s): autologous BMMNC stem cells; standard care
Intervention type(s): Biological; Other
Intervention description(s): Autologous BMMNC injected in the ipsilateral MCA
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: test group :Stem cell plus standard care control group : standard care
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Efficacy and Safety of Increasing Doses of DaxibotulinumtoxinA for Injection (DAXI for Injection) in the Treatment of Moderate or Severe Lateral Canthal Lines
Condition: Lateral Canthal Lines
Study type: Interventional
Phase: Phase 2

Summary: 
      A Phase 2a, Multicenter, Open-Label, Dose-Escalation Study to Evaluate the Treatment of
      Moderate or Severe Lateral Canthal Lines (LCL).
    


Intervention name(s): DaxibotulinumtoxinA for injection
Intervention type(s): Biological
Intervention description(s): Intramuscular injection
Intervention MeSH terms: Botulinum Toxins, Type A; abobotulinumtoxinA
Allocation: Non-Randomized
Intervention model: Sequential Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Lateral canthal wrinkle; Crow's feet lines; LCL
Application of the Apsara Thermal Wand System
Condition: Tightening of Skin Laxity
MeSH terms: Cutis Laxa
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The purpose of this feasibility study is to gain an initial assessment of the acute safety
      and performance of the Apsara Thermal Wand System in human facial tissue.
    


Intervention name(s): Apsara Thermal Wand System
Intervention type(s): Device
Intervention description(s): Single radiofrequency cycle to dermal tissue
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: skin laxity, wrinkles, rhytids
Therapeutic Hepatitis B Vaccine (Mimogen-based) Joint Entecavir in Treating Chronic Hepatitis B Patients
Condition: Chronic Hepatitis B
MeSH terms: Hepatitis A; Hepatitis B; Hepatitis B, Chronic; Hepatitis; Hepatitis, Chronic
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose is to evaluate efficacy and safety of therapeutic hepatitis B virus (HBV) vaccine
      (mimogen-based)) Joint entecavir treatment in chronic hepatitis B patients.
    

Detailed description: 
      Eligible subjects are enrolled and assigned into 2 groups randomly with a 1:1 ratio：

        1. Therapeutic HBV vaccine Joint Entecavir group：Inject εPA-44 900μg at week 0, 3, 6, 9,
           12, 15, 18, 21, 24, 28, 32, 36, 40, 44, 48 + Oral intake entecavir 0.5mg per day ；

        2. Empty liposome Joint Entecavir group：Inject empty liposome at week 0, 3, 6, 9, 12, 15,
           18, 21, 24, 28, 32, 36, 40, 44, 48 + Oral intake entecavir 0.5mg per day.

      The study cycle consists of screening and enrollment period (week -4～0), treatment and
      follow-up period (week 0-96).
    

Intervention name(s): Therapeutic HBV vaccine; entecavir; placebo
Intervention type(s): Biological; Drug; Other
Intervention description(s): Inject εPA-44 900μg at week 0, 3, 6, 9, 12, 15, 18, 21, 24, 28, 32, 36, 40, 44, 48.; 0.5mg,per day,oral intake.; Inject placebo 900μg at week 0, 3, 6, 9, 12, 15, 18, 21, 24, 28, 32, 36, 40, 44, 48.
Other intervention name(s): εPA-44; Baraclude; empty liposome
Intervention MeSH terms: Entecavir
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Therapeutic HBV Vaccine; Chronic Hepatitis B; HBeAg positive; HBV-specific Cytotoxic T Lymphocyte
Orthodontic Retention on the Maxillary Stability After SARME Using Laser Scanner
Condition: Maxillary Hypoplasia
Study type: Interventional

Summary: 
      The objective of this study was to evaluate the effect of the orthodontic retainer on
      transverse maxillary dental and skeletal stability after SARME.
    

Detailed description: 
      Methods: Ninety digitized dental casts of 30 adult patients (18 males and 12 females)
      submitted to SARME using the Hyrax expansion appliance were evaluated. Patients were
      distributed into two groups: Group Without Retention (GSC) n = 15; and Group With Retention
      (GCC) n = 15. In the GCC group, a Transpalatal Arch (TPA) was installed for retention soon
      after removal of the expander. The dental casts were scanned using a Vivid 9i 3D laser
      scanner (Konica Minolta, Wayne, NJ). The plaster models were performed preoperatively (T1), 4
      months after the expander was removed (T2), and 10 months after the end of the expansion
      (T3). The distances measured were Inter-Cusps of Premolars and Molars (Inter-Cusp PM)
      (Inter-Cusp M), Inter-Cervicals of Premolars and Molars (Inter-Cervical PM) (Inter-Cervical
      M), Inter-WALA edges of Premolars and Molars (PM Inter-BW) (BW Inter-M), palatal height at
      the molar, and palatal area and volume at T1, T2, and T3.
    

Intervention name(s): Surgically Assisted Rapid Maxillary Expansion (SARME); Laser Scanner
Intervention type(s): Procedure; Other
Intervention description(s): Surgical technique is performed with subtotal LeFort I osteotomy with separation of the pterygomaxillary fissure.The procedure was performed under general anesthesia using endotracheal intubation. Following the osteotomies, the expander screw was activated to 1.6 mm intraoperatively until a small diastema was observed between the upper central incisors. The incision was sutured along two planes.; Laser Scanner Vivid 9i was used to digitize the study models. The 3d virtual dental casts is a reliable copy of the original dental casts. On this virtual casts all measurements (linear, area and volume of the palate) was done to evaluate the stability after SARME.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Palatal Expansion Technique; Orthognathic Surgery; Three Dimensional images
Efficacy of Platelet-rich Plasma (PRP) in the Treatment of Dark Circles Under the Eyes
Condition: Periorbital Hyperpigmentation
MeSH terms: Hyperpigmentation
Study type: Interventional

Summary: 
      10 ml of blood from each patient will be drawn. This blood specimen will be centrifuged in a
      specific way to get 1 ml of platelet rich plasma (PRP). PRP will be injected into the the
      skin under the eyes. The treatment course consists of three sessions of PRP injections with
      one-month intervals between the sessions.
    

Detailed description: 
      Background:

      Dark circles around the eyes is a common problem pretending with relatively dark eyelids
      concerns many patients, especially women, because of the inconvenience caused by esthetic and
      negative impact on the psyche and the patient's quality of life. There are several causing
      factors (such as sun exposure, smoking, alcohol, sleep deprivation, genetic and structural
      factors). variety of treatments have been used for this situation , but without clear
      results.

      The term 'Platelet-Rich Plasma (PRP)' is a general term used to describe hanging plasma that
      has been obtained from whole blood with concentration of platelets higher than normal
      concentration found in the circulating blood. PRP's work mechanism depends on the fact that
      platelets contain important substances called (growth factors), which have a known role in
      the process of reform and renewal of tissues.

      Aim of the research:

      This study was designed to evaluate the effectiveness of (PRP) injection in the treatment of
      dark circles under the eyes. This is an uncontrolled open therapeutic trial study which will
      be performed at the Hospital of Dermatology and Venereology of Damascus University in
      Damascus, Syria during the period from June 2016 to June 2017.

      The results will be assessed by standardized digital photography month after each injection
      and three months after the latest assessment with the assistant of skin colors scale. In
      addition, the patient's satisfaction with the results and any treatment-related side effects
      will be recorded.
    

Intervention name(s): PRP
Intervention type(s): Biological
Intervention description(s): PRP will be injected subcutaneously around the eyes at three different time points with one-month interval
Other intervention name(s): platelet-rich plasma
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Evaluation of a Daily Disposable Silicone Hydrogel Multifocal Contact Lens in Myopes and Hyperopes
Condition: Visual Acuity
Study type: Interventional

Summary: 
      This is a single-masked, single-arm, dispensing clinical trial that will evaluate vision, eye
      health and fit acceptance.
    


Intervention name(s): JJVC Investigational Multifocal Contact Lenses manufactured in senofilcon A C3
Intervention type(s): Device
Intervention description(s): TEST Lens
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
tSMS in Essential Tremor
Condition: Essential Tremor
MeSH terms: Tremor; Essential Tremor
Study type: Interventional
Phase: Phase 2

Summary: 
      This is randomized double-blind study to study the hypothesis that transcranial static
      magnetic field stimulation of the primary motor cortex improves tremor in patients with
      essential tremor. Half of the patients will receive tSMS of the left hemisphere and the other
      half of the right hemisphere.
    


Intervention name(s): tSMS; sham
Intervention type(s): Device; Device
Intervention description(s): Transcranial static magnetic field stimulation (tSMS) is a non-invasive brain stimulation (NIBS) technique that decreases cortical excitability (Oliviero et al., 2011; Oliviero et al., 2015; Dileone et al., 2018). Static magnetic fields suitable for tSMS are obtained with commercially available neodymium magnets. We will use a cylindrical neodymium magnet of 45 mm diameter and 30 mm of thickness, with a weight of 360 g (MAG45r; Neurek SL, Toledo, Spain), which will be applied with south polarity to the left or right motor cortex, using a tSMS helmet (MAGmv1.0; Neurek SL, Toledo, Spain).; A non-magnetic metal cylinder, with the same size, weight and appearance of the magnet, will be used for sham stimulation (MAG45s; Neurek SL, Toledo, Spain) of motor cortex contralateral to the stimulated hemisphere.
Other intervention name(s): MAGmv1.0 with MAG45r, Neurek S.L. (Toledo, Spain); MAGmv1.0 with MAG45s, Neurek S.L. (Toledo, Spain)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Clinical Evaluation of Polyherbal Coded Formulation Obesecure for Leptin Regulation and Obesity Management
Condition: Leptin Deficiency; Obesity
MeSH terms: Obesity; Obesity, Morbid
Study type: Interventional
Phase: Phase 2

Summary: 
      The study was designed to explore an alternative approach to reduce weight in human beings
      using a polyherbal formulation. A polyherbal formulation named as Obesecure was developed
      after screening of local medicinal flora. The formulation was further improved after pilot
      studies and Phase-I Clinical Trials.
    

Detailed description: 
      Obesity is a common disease of developing countries including Pakistan. Obesity is a risk
      factor for many diseases which can be life-threatening or making the person unable to perform
      daily routine work. Obesity is considered a risk factor for different diseases like
      cardiovascular diseases, hormonal imbalance, infections, malignancies and chest problems. The
      leptin hormone has appetite suppressing and energy dissipation activity in the body. A
      screening study on animals was carried out to find out the leptin enhancing medicinal plants
      from locally available plants in Pakistan. This study was aimed to see the combined effects
      of the Leptogenic drug Obesecure on weight management.

      Patients of age20 to 50 years with BMI more than 25, not taking any anti-obesity drugs
      one-month prior to start of study were enrolled. The Participants were randomly allocated to
      receive either Obesecure or placebo twice a day for three months in Shifa-ul-mulk Hospital,
      PRIEM Health Care Clinic (Pakistan) and Ria Eastern Medicine Clinic (Pakistan).

      An acute toxicity study showed no adverse effect of taking Obesecure prior to clinical
      trials.
    

Intervention name(s): Leptin Human
Intervention type(s): Drug
Other intervention name(s): Obesecure
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Multicentre, two arm parallel randomized controlled clinical trial
Masking: None (Open Label)
Primary purpose: Treatment
Vitamin D Supplementation in Obesity and Weight Loss (3DD Study)
Condition: Osteoporosis
MeSH terms: Osteoporosis; Weight Loss
Study type: Interventional

Summary: 
      In this study, we will provide supplemental vitamin D in postmenopausal overweight/obese
      women, and hypothesize that it will not affect areal BMD, but will alter bone compartments
      (trabecular and cortical bone). In addition, higher vitamin D intake will increase serum
      25OHD and suppress serum PTH and bone turnover during weight reduction. Secondary outcomes
      include the influence of vitamin D and weight loss on markers of insulin resistance and on
      cognitive tests of attention, learning, and memory.
    


Intervention name(s): 600 IU Vitamin D3; 2000 IU Vitamin D3; 4000 IU Vitamin D3
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Once daily; Once daily; Once daily
Intervention MeSH terms: Vitamin D; Ergocalciferols; Cholecalciferol; Vitamins
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Health Services Research
Reducing Eco-anxiety Using Selfies
Condition: Ecology; Anxiety
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      The purposes of this study are to test among adolescent viewers the utility of selfie
      (TikTok) short video-based interventions to:

        1. Reduce ecological anxiety,

        2. Increase ecological agency,

        3. Compare two different types of messaging, and

        4. Examine the role of viewer's gender and race as independent factors on the outcomes of
           interest.
    

Detailed description: 
      Intervention videos will each be TikTok self-recorded videos (of 58-second duration)
      featuring the same underage professional (ages 16) acting as simulated participant. Video 1
      ("Negative") will focus on impending ecological catastrophic outcomes; Video 2 ("Positive")
      will focus on the actions that youth will be able to take in preventing such outcomes; and
      Video 3 ("Neutral") will include content unrelated to ecological concerns.

      We intend to assign ~1,000 individuals aged 14-18 in a randomized way, in equal proportions,
      and stratified by sex and race, to view one of the three TikTok videos: Positive, Negative,
      or Neutral.

      Assessments will occur at baseline and post-intervention, and will include:

        1. Demographics (baseline only),

        2. Primary outcome:

           a. Climate Change Anxiety scale (13 items)

        3. Secondary outcome:

             1. Climate Hope scale (11 items)

             2. Behavioral intentions (6 items; adapted from)29,

             3. Hopefulness and agency sliders (2 items), and

             4. Three words
    

Intervention name(s): Short videos
Intervention type(s): Behavioral
Intervention description(s): Intervention videos will each be of 90-second duration and feature four underage professionals (ages 16) acting as simulated patients. All videos will focus on an empowered presenter with depression sharing their personal story regarding depression and describe how social supports from family, friends, and community, as well as professional help assisted them in overcoming symptoms of their illness. The actors will include a transgender male, a cis-gender male, a transgender female, and a cis-gender female.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Prevention
Efficacy of NNC109-0012 in Subjects With Active Rheumatoid Arthritis
Condition: Inflammation; Rheumatoid Arthritis
MeSH terms: Arthritis; Arthritis, Rheumatoid; Inflammation
Study type: Interventional
Phase: Phase 2

Summary: 
      This trial is conducted in Europe. The aim of this trial is to evaluate the change in disease
      activity following 12 weekly s.c. (under the skin) doses of NNC109-0012 compared to placebo
      in subjects with active Rheumatoid Arthritis (RA).
    


Intervention name(s): NNC109-0012; placebo
Intervention type(s): Drug; Drug
Intervention description(s): The subjects will receive 12 weekly doses of 3 mg/kg of NNC109-0012 administered subcutaneously (under the skin); The subjects will receive 12 weekly doses of 3 mg/kg of Placebo administered subcutaneously (under the skin)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Effects of Consuming Sugar-Sweetened Beverages With Meals for 10 Weeks
Condition: Metabolic Syndrome; Insulin Resistance; Dyslipidemia
MeSH terms: Metabolic Syndrome; Insulin Resistance; Dyslipidemias
Study type: Interventional

Summary: 
      The purpose of this study is compare the effects of consuming glucose- and fructose-sweetened
      beverages on appetite, body weight, body fat, and the amount of energy the body burns as well
      as effects on blood pressure, hormones, blood triglycerides and cholesterol, and the body's
      sensitivity to the insulin.
    

Detailed description: 
      The study is designed as a prospective, blinded diet intervention study during which the
      participants consume either fructose- or glucose-sweetened beverages (25% of energy) with
      meals. Experimental procedures, including 24-hour serial blood sampling, 26-h stable isotoped
      infusions, post-heparin blood collection, gluteal biopsies, metabolic rate monitoring,
      computed tomography scans of the abdomen, and Oral Glucose Tolerance and Disposal Tests, are
      performed during baseline and at the end of a 10-week intervention period at the UC Davis
      School of Medicine/Sacramento Veterans Affairs Medical Center Clinical Research Center
      (CCRC). During the 2-week inpatient baseline period, subjects are served energy balanced
      diets containing 15% of energy as protein, 30% as fat, and 55% as complex carbohydrate.
      Following the baseline period, the subjects reside at home for 8 weeks and consume their
      usual ad libitum diet along with 25% of energy requirements as fructose- or glucose-sweetened
      beverages. Subjects then return to the CCRC for the 2-week inpatient intervention period at
      the end of the study and are served energy-balanced diets containing 15% of energy as
      protein, 30% as fat, 30% as complex carbohydrate and 25% of energy as fructose- or
      glucose-sweetened beverage.
    

Intervention name(s): Glucose; Fructose
Intervention type(s): Other; Other
Intervention description(s): 25% dose at 8-week intervention assigned to subjects.; 25% dose at 8-week intervention assigned to subjects.
Other intervention name(s): sugar; sugar
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science