bioihbjkbjnl/mcl2 huggingface dataset:
Endocannabinoid and Psychological Responses to Yoga in Healthy Adults
Condition: Healthy
Study type: Interventional

Summary: 
      This study evaluates the acute effect of yoga on plasma levels of endocannabinoids and mood
      (i.e., mood disturbance, anxiety, pain) compared to one session of quiet rest. Participants
      completed one session of yoga and one session of quiet rest on two separate days.
    


Intervention name(s): Yoga; Quiet Rest
Intervention type(s): Behavioral; Behavioral
Intervention description(s): 1 session; 1 session
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: The proposed study is an acute, single group, crossover pilot study where participants will complete control and experimental conditions.
Masking: None (Open Label)
Primary purpose: Other
AGN-241751 in the Treatment of Major Depressive Disorder
Condition: Major Depressive Disorder
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The purpose of this study is to evaluate the efficacy and safety of AGN-241751 in
      participants with Major Depressive Disorder
    


Intervention name(s): AGN-241751; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): AGN-241751 is supplied in tablet form; Placebo is supplied in tablet form
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Determine the Point of View of Society Society to Natural Orifice Surgeon
Condition: Health, Subjective
Study type: Interventional

Summary: 
      200 participants' perception and acceptability of natural hole surgeon
    

Detailed description: 
      100 participants health personnel 100 participants population two group's perception and
      acceptability of natural orifice surgeon
    

Intervention name(s): natural orifice surgery
Intervention type(s): Procedure
Intervention description(s): evaluation of the awareness of the use of transvaginal, transoral and transcranial approach in surgical excision and the difference between the health staff and the pathology
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
A Multi-Component Alcohol and Sex Risk Intervention for College Students
Condition: College Drinking
MeSH terms: Alcohol Drinking in College
Study type: Interventional

Summary: 
      Hazardous alcohol use, sexually transmitted infections, and sexual violence are interrelated
      and highly prevalent public health concerns in college student populations. The current study
      seeks to develop a tri-pronged sex-positive intervention that addresses risky alcohol use,
      unsafe sex, and sexual violence for college men and women (ages 18-24). The study involves a
      small randomized pilot trial to demonstrate the feasibility and acceptability of the
      recruitment methods and research design. Preliminary evidence of intervention efficacy will
      also be evaluated.
    


Intervention name(s): SPLASH Intervention Condition; Control Condition
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Two-session in person group discussions focusing on behaviors in drinking contexts; Two-session in person group discussions focusing on college health behaviors
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Study in Healthy Young Women to Investigate the Pharmacodynamics, Pharmacokinetics and Safety of Vilaprisan
Condition: Clinical Trial, Phase I
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a study in healthy women of reproductive age to investigate the pharmacodynamics
      (mainly ovarian activity), pharmacokinetics and safety of vilaprisan after daily oral
      administration of 4 different doses over 84 days, using a randomized, parallel-group,
      multicenter design.
    


Intervention name(s): Vilaprisan (BAY1002670)
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Using Behavioral Science to Improve Colorectal Cancer Screening Rates With Mailed FIT Kits
Condition: Colorectal Cancer Screening
MeSH terms: Colorectal Neoplasms
Study type: Interventional

Summary: 
      As a part of UCLA Health's continued goal of improving patient care the investigators are
      updating our mailing campaign for our FIT Kit colorectal cancer screening that the
      investigators administer 2 times per year to include an automated phone call reminder to
      patients who are overdue for average-risk colorectal cancer screening and enrolled in a
      mailed FIT program. This will help the investigators evaluate if automated phone calls are
      effective at improving compliance with CRC screening, in addition to mailed FIT and embedded
      electronic health record (EHR) portal messages to patients.
    

Detailed description: 
      UCLA Health has a biannual mailed FIT program designed to capture patients overdue for CRC
      screening who are average-risk for CRC. With every campaign, the investigators attempt to
      improve the return rates for patients receiving the FIT Kits. For the current campaign, all
      patients enrolled will receive usual care and the investigators are delivering an automated
      phone call to half the eligible patients reminding them to return their FIT kits and
      prompting them to request a new kit if needed. The investigators will investigate if this
      intervention increases the number of patients who complete the mailed Fit Kit or any type of
      CRC screening over a 6-month follow up period. This quality improvement project will help the
      investigators improve the processes of care for the patients, and community. If this phone
      call is successful the investigators will likely expand it to the entire population in future
      FIT Kit mailer campaigns. However, if it is not effective this will help the investigators
      minimize the number of calls/interventions the investigators send to patients and will
      hopefully allow for more useful outreach to patients in the future.
    

Intervention name(s): Delayed automated phone call
Intervention type(s): Behavioral
Intervention description(s): Cipher provides automated phone calls to patients; in this case the script for Cipher was modified to provide patients a reminder to return FIT kits, allow patients to request a new kit in case they need a replacement, and to allow patients to provide information if they already completed CRC screening
Other intervention name(s): Cipher phone reminder
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: ~2500 patients who are overdue for average-risk CRC screening and are enrolled in UCLA Health biannual mailed FIT program will be randomized to either control (mailed FIT kit + standard messaging) or intervention (mailed FIT Kit + standard messaging + delayed automated phone reminder)
Masking: None (Open Label)
Primary purpose: Screening
Phase 1 XG005-03 Topical Study
Condition: Pain
Study type: Interventional
Phase: Phase 1

Summary: 
      Phase 1, randomized, single-blinded, placebo-control, ascending single and multiple dose of
      the PK, safety, and tolerability of XG005-03 topical formulation in Healthy Volunteers.
    

Detailed description: 
      This is a single-blind, placebo-controlled study which will investigate the PK, safety and
      tolerability of XG005-03 topical formulation, in three ascending concentrations after single
      and multiple topical applications in healthy subjects. The trial consists of two parts: a
      single ascending dose (SAD; Part 1) and a multiple ascending dose (MAD; Part 2). The MAD
      study will begin after the SAD portion of the study is complete.

      The study will consist of 4 weeks of screening period, treatment period (1 day of dosing for
      SAD and 6.5 days for MAD), and 14 days of safety follow-up period. Each subject will serve as
      his/her own control, as the XG005-03 and placebo will be applied on contralateral legs.
      Application of XG005-03 or placebo to a particular leg will be randomly assigned.

      Approximately 36 healthy subjects will be enrolled. Eighteen healthy subjects (3 alternates
      per dose group) in Part 1 (SAD) and Part 2 (MAD), who fulfill eligibility criteria will
      receive the study drug: XG005-03 (1%, 5%, and 10%) and placebo.
    

Intervention name(s): XG005-03; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 3 different concentrations (1%, 5%, 10%) of XG005-03 topical formulation; Placebo topical formulation
Allocation: Randomized
Intervention model: Sequential Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Difficult Intubation and Tongue Protrusion
Condition: Difficult Intubation, Tongue Mobility
Study type: Interventional

Summary: 
      Objectives: The aim of study is to determine the possible usage of tongue movements out of
      the mouth in the prediction of difficult intubation.

      Method: Two hundred twenty three patients undergoing abdominal surgery with general
      anesthesia between 2014 and 2015 were enrolled in this study. Difficult intubation was
      evaluated using the intubation difficulty scale (IDS) score. All intubations were performed
      by anesthesiologist to eliminate the differences among the anesthesiologists' experiences.
      IDS score were evaluated by anesthesiologists who had no idea about the measurements of the
      tongue movements and performed laryngeal intubation in all patients.

      To define the tongue movements, horizontal lines were used. Horizontal line were passing
      through the mid points of mandible and upper lip height. Patients were asked to protrude
      tongue maximally and upward (PTMU), to protrude tongue maximally and downward (PTMD) in
      anatomical neutral position which was sitting down on a chair.
    


Intervention name(s): Protrude tongue maximally and upward (PTMU); Protrude tongue maximally and downward (PTMD)
Intervention type(s): Other; Other
Intervention description(s): The horizontal line was passing through the mid points of the distance between subnasale to stomion (upper lip height). Patients were asked to protrude tongue maximally and upward (PTMU).; The horizontal line was passing through the mid points of the distance between stomion to mentum (mandible height). Patients were asked to protrude tongue maximally and downward (PTMD).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Diagnostic
Effect of Epidural Hydromorphone Combined With Ropivacaine in Labor Analgesia
Condition: Analgesia; Labor Pain
MeSH terms: Labor Pain
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to compare the effects of three different doses of hydromorphone
      combined with ropivacaine and sufentanil combined with ropivacaine in epidural labor
      analgesia through prospective clinical trials, so as to explore whether hydromorphone
      combined with ropivacaine has advantages in epidural labor analgesia, and find out the
      optimal dose of hydromorphone.

      Participants will be randomly allocated to four groups: H1 group,H2 group,H3 group and SF
      group.For those in H1 group: they will be administered with15 ug/ml hydromorphone and 0.08%
      ropivacaine for epidural labor analgesia, For those in H2 group: they will be administered
      with17.5 ug/ml hydromorphone and 0.08% ropivacaine for epidural labor analgesia, For those in
      H3 group: they will be administered with 20 ug/ml hydromorphone and 0.08% ropivacaine for
      epidural labor analgesia, For those in SF group: they will be administered with 40 ug/ml
      sufentanil and 0.08% ropivacaine for epidural labor analgesia.

      The goal of this clinical trial is to provide a new treatment option for pregnant women in
      epidural labor analgesia, and to provide a basis for hydromorphone combined with ropivacaine
      in epidural labor analgesia.
    


Intervention name(s): Hydromorphone; Sufentanil; Ropivacaine
Intervention type(s): Drug; Drug; Drug
Intervention description(s): For those in H1 group: they will be administered with15 ug/ml hydromorphone, For those in H2 group: they will be administered with17.5 ug/ml hydromorphone , For those in H3 group: they will be administered with 20 ug/ml hydromorphone; For those in SF group: they will be administered with 40 ug/ml sufentanil; 0.08% ropivacaine will be co-administrated for epidural labor analgesia in four arms
Intervention MeSH terms: Sufentanil; Hydromorphone; Ropivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
A Study in Healthy Women to Test Whether BI 425809 Influences the Amount of a Contraceptive in the Blood
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The main objective of this trial is to investigate the possible effect of multiple oral doses
      of BI 425809 on the steady state pharmacokinetics of ethinylestradiol (EE) and levonogestrel
      (LNG) (administered as the combined oral contraceptive Microgynon®).
    


Intervention name(s): Microgynon®; BI 425809
Intervention type(s): Drug; Drug
Intervention description(s): ethinylestradiol (EE) and levonorgestrel (LNG); BI 425809
Intervention MeSH terms: BI 425809; Ethinyl estradiol, levonorgestrel drug combination; Ethinyl Estradiol-Norgestrel Combination
Intervention model: Single Group Assignment
Intervention model description: Fixed sequence: Run in period-Reference-Treatment
Masking: None (Open Label)
Primary purpose: Treatment
HealtheTech Lifestyle Program
Condition: Obesity
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of the study is to determine the efficacy of resting metabolic rate (RMR) using
      BodyGem and BalanceLog in helping overweight and obese individuals manage their weight.
    

Detailed description: 
      The study plans are to develop and test the efficacy of a practical, structured, and
      time-limited behavioral intervention (HealtheLifestyle Program) as a supplement to standard
      HealtheTech products. Approximately 130 participants will be recruited and randomized to
      either the HealtheTech Program (focusing on calorie and exercise goals using the BalanceLog
      for tracking), the HealtheLifestyle Program (using step counters, monthly email letters and
      calls providing information on activity, nutrition, and weight loss), or a delayed treatment
      program (after 3 months undergo the intervention above).
    

Intervention name(s): HealtheLifestyle Program; step counters with monthly feedback on logs
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single
Keywords: weight control; compliance; physical activity; nutrition; Health Behavior; Patient Compliance
Colonization With Group B Streptococcus During Pregnancy
Condition: Gestational Mother; Streptococcus Agalactiae Infection
MeSH terms: Streptococcal Infections
Study type: Observational

Summary: 
      An observational study to estimate the probability of pregnant women, who were GBS-negative
      in the first trimester of pregnancy become GBS-positive at the end of pregnancy. It is an
      observational. One hundred pregnant women in the first trimester of pregnancy (11 ± 2 weeks)
      will be invite to participate in this prospective study. If accept, a vagino-rectal swab will
      collected for a GBS detection analysis. When negative, participants will be follow by their
      gynecologist with the normal routine procedures. During 35 week of pregnancy a vagino-rectal
      swab will be collected and analyzed to detect GBS. Then, a final visit will be completed one
      month after delivery.
    

Detailed description: 
      Healthy pregnant women reporting to the clinic in their first trimester of pregnancy (week 11
      ± 2 weeks of pregnancy) will be asked to participate in this study. Participation will be
      voluntary and written informed consent will be obtained from each participant. The study
      visits will take place in the hospital.

      At Visit 1, the inclusion and exclusion criteria will be verified. After signing the informed
      consent, a physical examination will be performed in addition to a vaginal-rectal swab to
      detect if they are GBS-negative. Information on the demographic profile and medical history
      will be collected. The investigator will explain to the participant that she cannot use any
      probiotic during the course of the study.

      At Visit 2, within 21-23 weeks ± 4 days of gestation, the inclusion and exclusion criteria
      will be reviewed. If the result of the microbiological analysis of the vaginal-rectal exudate
      is negative, the pregnant women shall continue in the study. A physical examination will be
      performed. Adverse Events occurring from the time of study inclusion will be recorded.

      At the third visit (Visit 3, 35 weeks ± 4 days of gestation), all participants continuing in
      the study will undergo a general physical examination. A sample of vagino-rectal exudate will
      be collected. Adverse Events occurring during the period between Visit 2 and Visit 3 will be
      recorded.

      During Visit 4 (1 month after delivery), all participants will have a general physical
      examination. Adverse Events occurring since Visit 3 will be recorded. Data will be collected
      on the delivery and occurrence of early- or late-onset GBS sepsis in the newborn during the
      first month of life.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        100 pregnant women GBS (-)
      
Biospecimen description: 
      Vagino-rectal exudate from participant will be collected at visit 1 and 3 to detect the
      presence of Group B Streptococcus. After that, they will be destroyed.
Weissella Cibaria JW15 Consumption and NK Cell Activity
Condition: Immune Function
Study type: Interventional

Summary: 
      A The aim of this study was to investigate the impact of consuming Weissella cibaria (W.
      cibaria) JW15 supplementation isolated from Kimchi, Korea traditional fermented food, on
      natural killer (NK) cell activity and circulating levels of cytokines and immunoglobulin
      (Ig).
    

Detailed description: 
      A randomized, double-blinded, placebo-controlled study was conducted on 100 nondiabetic
      subjects. Over an eight-week testing period, the probiotic group consumed 4 capsules (300
      mg/capsule) containing 1 x 10^10 colony-forming units (cfu) of W. cibaria JW15 each day,
      whereas the placebo group consumed the same product without a probiotic.
    

Intervention name(s): Placebo; Probiotic
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 4 capsules (300 mg/capsule) containing 52% crystalline cellulose and 46% lactose in identical-looking with test product; 4 capsules (300 mg/capsule) containing each capsule 1.0 x 10^10 colony-forming units (cfu) of Weissella cibaria JW15, twice a day
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Supportive Care
Acceptability of Fluzone Intradermal Vaccine to Patients and Vaccine Administrators
Condition: Patient Response to Fluzone ID Vaccine
Study type: Observational

Summary: 
      To assess the acceptance of the Fluzone Intradermal (ID)vaccine in adults and vaccine
      administrators in the United States. Patients completed 2 surveys, one immediately
      post-vaccination and one seven days later, that documented demographics and assessed their
      injection pain, injection anxiety, speed of injection, overall satisfaction, and preference
      for next year's vaccine. Vaccine administrators completed one survey assessing ease of
      vaccine preparation and administration, time required to administer, and safety/risk of
      needle stick injury for patient and administrator.
    

Detailed description: 
      Patients were divided into two groups: 1) those that reported receiving the intramuscular
      (IM) influenza vaccine in the past 3 years; and 2) those that reported not receiving the IM
      influenza vaccine in the past 3 years. The survey responses were compared between the two
      groups. In addition, the subjects that reported receiving the IM vaccine in the past 3 years
      were asked to compare their experience with the IM vaccine versus the ID vaccine.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        community sample
      
Keywords: Fluzone Intradermal vaccine
Effects of Hypopressive Exercises in Comparison With Routine Pelvic Floor Exercises in Women With Urinary Incontinence
Condition: Urinary Incontinence
MeSH terms: Urinary Incontinence; Enuresis
Study type: Interventional

Summary: 
      The aim of our study is to compare the effects of hypopressive exercises with routine pelvic
      floor exercises in improving the frequency and severity of urinary incontinence in women and
      also to enhance their quality of life as it worsens after childbirth, pregnancy, and in older
      age.
    

Detailed description: 
      A randomized control trial study will be conducted in which patients with urinary
      incontinence will be assigned to group 1 that will receive hypopressive exercises with
      electrical muscle stimulation (EMS) and patients in group 2 will receive pelvic floor
      exercises with EMS.

      The intervention will be applied (3 days/week) for 8 weeks. Four sets of 10 repetitions with
      a 3-minute interval between each set will be performed for group 1 in an upright position
      while four sets of 10 repetitions with a 2-minute interval between each set will be performed
      for group 2 in the sitting position.
    

Intervention name(s): Hypopressive exercises; Pelvic floor exercises
Intervention type(s): Other; Other
Intervention description(s): For hypopressive exercises, the patient will be instructed to inhale, then breathe to expand the ribcage, and then exhale completely. Hold the breath out before relaxing core and ribcage.; For pelvic floor exercises, the patient is instructed to hold each contraction for 6 seconds.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Urinary Incontinence; Pelvic floor exercises; Hypopressive exercises