bioihbjkbjnl/mcl2 huggingface dataset:
Comparing the Effects of Neck Stabilization Exercises Verses Dynamic Exercises Among Patients Having Nonspecific Neck Pain With Forward Head Posture
Condition: Non-specific Neck Pain
MeSH terms: Neck Pain
Study type: Interventional

Summary: 
      the objective of this randomized clinical trial is to compare the effectiveness of neck
      stabilization exercises versus neck dynamic exercises in patients having non specific neck
      pain with forward head posture for pain intensity, correction of forward head posture,
      increasing Range of movement and decrease functional disability. the study is being conducted
      at physiotherapy department of institute of physical medicine and rehabilitation (Dow
      university of health sciences) total 60 patients with non specific neck pain with forward
      head posture recruited by non-probability sampling technique initially screening done by
      consultant physicians who is blinded to the treatment given to patients. patient are included
      in study who fulfill inclusion criteria and sign the consent form. patients then randomly
      allocated to both treatment groups using computer generated randomization sheet. baseline
      assessment is taken at first session after providing 9 treatment of stabilizing exercises to
      group1 and dynamic exercises to group 2 session post assessment will be done on goniometry,
      NDI, VAS and plumb line at last session at third week.
    


Intervention name(s): Stabilization exercises; Dynamic exercises
Intervention type(s): Other; Other
Intervention description(s): The activation of deep cervical muscle to reduce the activity of surface muscles is known as stabilization exercises; The exercises in which muscle tension remains constant but muscle length changes is known as dynamic exercises
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: it is a randomized clinical trial. total 60 patients will be recruited 30 in each group. both groups are treatment group. treatment of group 1 is stabilization exercises and group 2 is dynamic exercises. patients are allocated randomly randomization is done by computer generated software sheet
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Neck Aches; Isotonic Contractions; Muscle Strength; Rehabilitation Exercises; Treatment
Long-Term Efficacy and Safety of CT-P10 in Patients With RA
Condition: Rheumatoid Arthritis
MeSH terms: Arthritis; Arthritis, Rheumatoid
Study type: Interventional
Phase: Phase 1

Summary: 
      This is an open-label, single-arm, multicenter, efficacy, and safety maintenance study of the
      Phase 1 Study CT-P10 1.1. This study is designed to assess the long-term efficacy and safety
      of CT-P10 co-administered with MTX and folic acid in patients with RA who have completed the
      scheduled visits in Study CT-P10 1.1
    


Intervention name(s): Rituximab, MTX, folic acid
Intervention type(s): Drug
Intervention description(s): Rituximab IV 1000mg MTX 10~25mg/week Folic acid at least 5mg/week
Other intervention name(s): Rituximab=CT-P10
Intervention MeSH terms: Folic Acid; Rituximab
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of Eating Within a Limited Time on Sugar Sensitivity and Liver Sugar Stores of People With Type 2 Diabetes.
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypersensitivity
Study type: Interventional

Summary: 
      Modern life is characterized by a 24-hour lifestyle in which food intake is no longer
      restricted to daytime. As a result, people nowadays tend to eat throughout the day. When food
      is being consumed the energy is both used and stored for later use. Eating for a prolonged
      period of time makes it unnecessary for the body to use its energy storage. It is
      hypothesized that the decreased use of energy stores has detrimental effects on our sugar
      balance, mainly on insulin sensitivity. Conversely, eating within a limited period during the
      day could improve insulin sensitivity in people with type 2 diabetes by an increased use of
      energy reserves, specifically liver sugar stores. Therefore, this study examines the effect
      of eating within a limited time frame during the day on insulin sensitivity and liver sugar
      stores of people with type 2 diabetes.
    

Detailed description: 
      Modern life is characterized by a 24-hour lifestyle in which food intake is no longer
      restricted to daytime. Interestingly, the majority of people spread their food intake over
      ~15 hours per day. This implies that most people experience a relatively short
      post-absorptive (fasting) state during night time. Normally, the body relies heavily on
      hepatic glycogen content to provide glucose and energy during the night, and glycogen stores
      will therefore decrease over night. In the morning, ingested carbohydrates will be taken up
      rapidly to replenish glycogen stores. It is hypothesized that in people with type 2 diabetes
      mellitus (T2DM) hepatic glycogen stores may not fully deplete overnight and that restricting
      food to a shorter period of time during the day will lead to a reduction of hepatic glycogen
      stores, and thereby improve whole-body insulin sensitivity at the beginning of the day.
      Therefore, the aim of this study is to investigate if time restricted feeding (TRF) leads to
      a reduction in overnight-fasted hepatic glycogen stores and improvement in insulin
      sensitivity in adults with T2DM.
    

Intervention name(s): Time restricted feeding; Control
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Eating within a time frame of 10hrs during the day. Outside of this time frame, participants need to refrain from food and energy containing drinks.; Eating for at least 14hrs per day.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Randomised controlled cross-over design with two 3-week arms and a 4-week wash-out period.
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: TRF; Hepatic glycogen; Type 2 diabetes; Insulin sensitivity
Evaluation of the Safety and Potential Therapeutic Effects of Cordstem-ST in Patients With Cerebral Infarction
Condition: Cerebral Infarction
MeSH terms: Cerebral Infarction; Infarction
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The objective of the study is to evaluate the safety and the potential therapeutic effects
      per dose of Cordstem-ST Intravenous Transplantation in Cerebral Infarction subjects
    

Detailed description: 
      Cohort 1 : Cordstem-ST 2.0 x 10^8 cells or Placebo on day 0 Cohort 2: Cordstem-ST 2.0 x 10^8
      cells or Placebo on day 0 and day 7
    

Intervention name(s): Cordstem-ST; Placebo
Intervention type(s): Biological; Biological
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Cerebral Infarction; Mesenchymal Stem Cells; Stroke
Megestrol Acetate Plus LNG-IUS in Young Women With Early Endometrial Cancer
Condition: Endometrial Neoplasm Malignant Stage I
MeSH terms: Endometrial Neoplasms; Neoplasms
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      To see if megestrol acetate plus Levonorgestrel-releasing intrauterine system (LNG-IUS) will
      not be inferior to returning the endometrial tissue to a normal state than megestrol acetate
      alone in patients with early endometrial cancer.
    

Detailed description: 
      After diagnosed of endometrioid endometrial cancer (EEC) by hysteroscopy, patients will be
      enrolled. Age, waist circumstances, blood pressure, basic history of infertility, blood
      pressure, serum lipid level and side effects will be collected. Blood tests, including
      fasting blood glucose (FBG), postprandial blood glucose (PBG), fasting insulin (FINS), SHBG,
      sex hormone levels, blood lipids and anti-müllerian hormone(AMH) will be performed before
      treatment to evacuate their metabolic conditions.

      Patients are randomized to 1 of 2 treatment groups. Patients will receive MA (megestrol
      acetate) 160 mg by mouth daily for at least 3 months on Arm I. Patients will receive MA 160
      mg plus LNG-IUS insertion for at least 3 months on Arm II. Then an hysteroscope will be used
      to evaluate the endometrial condition every 3 months, and the findings will be recorded. For
      patients with EEC, complete response (CR) is defined as the reversion of endometrial disease
      to proliferative or secretory endometrium; partial response (PR) is defined as regression to
      simple or complex hyperplasia without atypic or atypical hyperplasia; no response (NR) is
      defined as the persistence of the disease; and progressive disease (PD) is defined as the
      progression of endometrial lesions. Continuous therapies will be needed in PR, NR or PD.

      As the reason of the low response rate of LNG-IUS alone in EC patients (nearly 50%), and the
      potential limitation of LNG-IUS to focal cancer lesion in endometrial cavity, the
      investigators did not add LNG-IUS alone as a single control group.

      After completion of study treatment, 2 months of maintenance treatment will be recommended
      for patients with CR, and participants will be followed up for 2 years.
    

Intervention name(s): Megestrol Acetate; Levonorgestrel-releasing Intrauterine System(LNG-IUS)
Intervention type(s): Drug; Device
Intervention description(s): At a dosage of 160 mg/day; levonorgestrel 52mg. It is a hormone-releasing T-shaped intrauterine system.
Other intervention name(s): Megace; Mirena Intrauterine Device; Mirena
Intervention MeSH terms: Megestrol; Megestrol Acetate; Levonorgestrel
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Mifepristone for the Prevention of Relapses of Alcohol Drinking
Condition: Alcohol Use Disorders (AUD)
MeSH terms: Alcoholism; Alcohol Drinking
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The goal of this study is to determine if, under stress, alcohol drinking is reduced using
      mifepristone
    


Intervention name(s): Mifepristone 600-mg/day or placebo for a week
Intervention type(s): Drug
Intervention description(s): 600-mg of mifepristone for a week, compared to placebo for a week, in a stress-induced condition triggered by a single dose of 32.4 mg of yohimbine
Intervention MeSH terms: Mifepristone
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Stress, alcohol craving, alcohol use disorders
Pre-analytical Sample Handling Conditions and Their Effects on the Human Serum Metabolome
Condition: Healthy
Study type: Observational

Summary: 
      This study evaluates how blood serum handling conditions can affect the concentrations of
      ~1,000 serum metabolites and attempts to quantify the degree of attenuation and/or potential
      bias in epidemiologic associations that may result from less than optimal sample handling
      conditions.
    

Detailed description: 
      Metabolomics, the simultaneous quantification of concentrations of hundreds or thousands of
      metabolites simultaneously in a biological matrix, is a versatile analytical technique
      capable of accelerating biomarker-based discoveries in nutritional science. Recently,
      metabolomics has been applied to samples collected in feeding studies (1) and epidemiologic
      studies (2) to identify dozens of novel potential dietary biomarkers. Several large
      prospective cohort studies, many of which are collaborating in a metabolomics consortium led
      by the National Cancer Institute, have recently applied metabolomics to banked samples. This
      has made nutrition-related biomarkers suddenly available for tens of thousands of
      participants with follow-up for disease endpoints, enabling truly large-scale nutritional
      biomarkers and disease studies.
    

Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Men and women will be recruited from the area surrounding the BHNRC. There are several
        thousand government and privately employed workers located within a 10-mile radius of the
        BHNRC and several residential communities from which a cohort of volunteers will be
        recruited. The population includes an ethnically diverse group of subjects.
      
Biospecimen description: 
      serum and urine
AZD6765 for Treatment Resistant Depression
Condition: Depression
MeSH terms: Depression; Depressive Disorder
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine whether treatment with AZD6765 will have an
      antidepressant effect with patients who have treatment resistant depression.
    


Intervention name(s): AZD6765
Intervention type(s): Drug
Intervention description(s): intravenous infusion
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Long-term depression
Effects of Bisoprolol and Atenolol on Sympathetic Nervous Activity and Central Aortic Pressure in Patients With Essential Hypertension
Condition: Untreated Essential Hypertension
MeSH terms: Hypertension; Essential Hypertension
Study type: Interventional
Phase: Phase 4

Summary: 
      β-blockers (BBs) with different pharmacological properties may have heterogeneous effects on
      sympathetic nervous activity (SNA) and central aortic pressure (CAP), which are independent
      cardiovascular factors for hypertension. Hence, we analyzed the effects of bisoprolol and
      atenolol on SNA and CAP in hypertensive patients.
    


Intervention name(s): bisoprolol; atenolol
Intervention type(s): Drug; Drug
Intervention MeSH terms: Atenolol; Bisoprolol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Effects of Resistive Diaphragmatic Training on Chronic Stroke
Condition: Stroke (CVA) or TIA
MeSH terms: Stroke
Study type: Interventional

Summary: 
      To determine the effects of resistive diaphragmatic training on pulmonary function of chronic
      stroke patients. And also assessing their compromised respiratory functions
    

Detailed description: 
      This study is to examine the effects of Diaphragmatic breathing exercises with resistance and
      Digital spirometer training for improving pulmonary functions in chronic stroke patients.
      Diaphragmatic Resistance training is based on the same principal as for the any other
      Skeletal Muscle training. The selection of 20 subjects divided equally and placed into an
      experimental group and a control group and the interventions would applied three times per
      week for 4 weeks. In each session, both groups receive Digital spirometer training for 15
      minutes. In addition, experimental group receive diaphragm breathing exercises with
      resistance for 30 minutes. Resistance is Applied through Different thera bands and then
      performing the Breathing Exercises. First of all resistance applied through yellow band(1-6
      pounds of resistance) and then red, Green and black which give (4-18 Pounds of resistance)
      The patient is asked to breath in deeply and slowly while not to move upper chest .Weight
      increased weekly as per patient's tolerance. Further Digital spirometer training Perform to
      determine the Pulmonary Functions FVC,FEV1,FVC/FEV1,PEF,VC. in both Control and Experimental
      Groups
    

Intervention name(s): Incentive spirometer training; diaphragmatic resistance exercises
Intervention type(s): Other; Other
Intervention description(s): Incentive spirometer training 5 sessions a week, each session of 15 minutes, for 4 weeks; Incentive spirometer with diaphragmatic resistance exercises. Resistance is applied through the different Thera bands and then performing the pursed lip breathing exercise. Resistance increased weekly as per tolerance by the patient.
Digital spirometer training for 15 minutes. diaphragm breathing exercises with resistance for 30 minutes. 5 sessions a week, for 4 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: stroke; resistive diaphragmatic training; pulmonary function
Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Voxilaprevir in Adults With Chronic Hepatitis C Virus Infection
Condition: Hepatitis C Virus Infection
MeSH terms: Infections; Communicable Diseases; Hepatitis A; Virus Diseases; Hepatitis C; Hepatitis C, Chronic; Hepatitis
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of the study is to evaluate the safety and tolerability of voxilaprevir
      (formerly GS-9857) alone or with sofosbuvir (SOF)/velpatasvir (VEL) fixed dose combination
      (FDC) and antiviral activity of voxilaprevir in adults with genotype 1, 2, 3, 4 hepatitis C
      virus (HCV) infection. All participants will be monitored for up to 48 weeks after the last
      dose.
    


Intervention name(s): Voxilaprevir; Placebo to match voxilaprevir; SOF/VEL
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Voxilaprevir tablets administered orally once daily; Placebo to match voxilaprevir tablets administered orally once daily; 400 mg/100 mg FDC tablet administered orally once daily
Other intervention name(s): GS-9857
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Sustained Virologic Response; Direct Acting Antiviral; Combination Therapy; Liver Diseases; Digestive System Diseases; Hepatitis, Viral, Human; Enterovirus Infections; Picornaviridae Infections; RNA Virus Infections; Flaviviridae Infections; Antiviral Agents; Anti-Infective Agents; Therapeutic Uses; Pharmacologic Actions; Antimetabolites; Molecular Mechanisms of Pharmacological Action
Remission Evaluation of a Metabolic Intervention in Type 2 Diabetes With Forxiga
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of the study is to determine whether in patients with early type 2 diabetes, a
      short-term intensive metabolic intervention comprising Forxiga, metformin, basal insulin
      glargine and lifestyle approaches will be superior to standard diabetes therapy in achieving
      sustained diabetes remission.
    

Detailed description: 
      This is a multicentre, open-label, randomized controlled trial in 152 patients with
      recently-diagnosed T2DM. Participants will be randomized to 2 treatment groups: (a) a 12-week
      course of treatment with Forxiga, metformin, insulin glargine and lifestyle therapy, and (b)
      standard diabetes therapy, and followed for a total of 64 weeks (1 year and 3 months). In all
      participants with HbA1C<7.3% at the 12 week visit, glucose-lowering medications will be
      discontinued and participants will be encouraged to continue with lifestyle modifications and
      regular glucose monitoring. Participants with HbA1C ≥ 7.3% at this visit or who experience
      hyperglycemia relapse after stopping drugs will receive standard glycemic management as
      informed by the current Canadian Diabetes Association clinical practice guidelines.
    

Intervention name(s): insulin glargine; metformin; Forxiga; Lifestyle therapy
Intervention type(s): Drug; Drug; Drug; Behavioral
Intervention description(s): Dose is titrated to achieve fasting normoglycemia; Dose is titrated to 1 g bid or maximal tolerated dose; Dose is titrated to 10 mg po daily or maximal tolerated dose; Lifestyle intervention includes individualized dietary and exercise advice and frequent visits for goal reinforcement, behavior modification and problem-solving
Other intervention name(s): Lantus; dapagliflozin; diet and exercise
Intervention MeSH terms: Metformin; Insulin Glargine; Dapagliflozin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Diabetes; Insulin; Glargine; Metformin; Forxiga; Diet; Exercise; Lifestyle
Efficacy of Sana Treatment in Fibromyalgia
Condition: Fibromyalgia
MeSH terms: Fibromyalgia; Myofascial Pain Syndromes
Study type: Interventional

Summary: 
      The purpose of this research study is to evaluate the effectiveness of an experimental device
      called the Sana Pain Reliever Device (Sana Device) on treating pain due to fibromyalgia.
    


Intervention name(s): Sana Sham Device
Intervention type(s): Device
Intervention description(s): Externally worn mask that physically contacts the skin of the face. The Sana Device delivers Audio Visual Stimulation (AVS) in the form of coordinated pulses of light (through closed eyelids) and sound at various frequencies.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Parallel 2-arm study in which patients will be randomly assigned to either active treatment or Sham control arms.
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Chinese Medicinal Treatment on Mild Hand, Foot, and Mouth Disease: Multicenter, Prospective, Randomized Double-blind, Placebo-controlled Study
Condition: Hand, Foot and Mouth Disease
MeSH terms: Foot-and-Mouth Disease; Hand, Foot and Mouth Disease; Mouth Diseases
Study type: Interventional

Summary: 
      The study is aimed to evaluate the effectiveness and safety of Jinlianqingre Effervescent
      Tablets, a traditional Chinese medicine (TCM), in the treatment of Uncomplicated hand, foot,
      and mouth disease (HFMD).
    

Detailed description: 
      By adopting a multicenter, prospective, randomized double-blind, placebo-controlled, this
      study is aimed to evaluate the effectiveness, safety of a traditional Chinese medicine,
      Jinlianqingre Effervescent Tablets, for treatment Uncomplicated HFMD, and to provide
      scientific evidence for the construction of TCM methods in treating HFMD.
    

Intervention name(s): Western therapy; JET; Placebo(for JET)
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Physical cooling paste or warm bathing, vitamin B, vitamin C. On the basis of the attending physician's judgment, participants were allowed to use Ibuprofen suspension if their body temperature was greater than 38.5℃. Likewise, the need for antibiotics was determined by the attending physicians. The use of acetaminophen or antibiotics was recorded on the case record form; 4g/tablet, One tablet each time (Taken after dissolved in 50ml boiled water, 3 times daily if body temperature≥38.5℃); placebos prepared identical in color, taste and consistency to the JET (supplied by Zhongshenghaitian Pharmaceutical, Tianjin, China)
Other intervention name(s): Jinlianqingre Effervescent Tablets
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Hand, Foot and Mouth Disease; Medicine, Chinese Traditional; Enterovirus; Fever