bioihbjkbjnl/mcl2 huggingface dataset:
Short Term Effect of Kinesiotaping In Patients With Shoulder Impingement Syndrome
Condition: Kinesiotape; Exercise; Ultrasound
MeSH terms: Shoulder Impingement Syndrome
Study type: Interventional

Summary: 
      We aimed to investigate the effect of kinesiotaping on pain, functionality and ultrasound
      parameters in patients with shoulder impingement syndrome (SIS).
    

Detailed description: 
      A total of 75 patients with SIS were randomly classified into the following three groups:
      kinesiotaping (KT), exercise (EX) and sham-kinesiotaping (sham-KT). Each group was underwent
      two weeks treatment program. The patients were then evaluated in terms of pain analyzed using
      the visual analog scale (VAS), joint range of motion, Quick-Disabilities of the Arm, Shoulder
      and Hand (Q-DASH) questionnaire before and after treatment. In addition, supraspinatus tendon
      (SsT) thickness and acromiohumeral distance (AHD) parameters were measured using
      ultrasonography (US). All parameters were measured before and after treatment.
    

Intervention name(s): Cold Application; Kinesiotaping Application; Exercise treatment; Sham Kinesio taping application
Intervention type(s): Other; Other; Other; Other
Intervention description(s): At the beginning of each treatment session, gel ice packs were wrapped in a damp towel and applied to the patients' shoulder joints for 20 minutes.; KT was applied to the deltoid muscle using the inhibition and mechanical correction technique and to the supraspinatus muscle using the inhibition technique (2 sessions with a 5-day interval); EX treatment was administered for 10 days with 3 sessions/day. A triphasic exercise program was administered to the patients. Before starting the exercise program, the patients were instructed to not perform the movements exceeding 90° overhead. The exercise program was initiated using codman pendulum, passive joint motion range (with a 1-m stick), and posterior capsule stretching exercise. Shoulder wheel, finger ladder, and shoulder strengthening exercise with theraband were added to the exercise programs of patients with full or near total range of motion and pain relief. Exercise was administered twice a week under supervision; however, the patients were advised to exercise at home on the other days with 20 repetitions of each exercise. The patients were followed up via telephone to make sure they were adhering to their exercise programs.; Sham-KT was applied in 10 cm I-shaped stripes on the sagittal plane over the acromioclavicular joint without stretching and on the transverse plane distal to the deltoid area. The kinesiotape was applied twice for five days with 2-day intervals
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A Randomized Sham-Controlled Study
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Kinesiotape; exercise; ultrasound
A Cohort Study to Determine the Incidence of Dengue Fever and to Build Capacity for Dengue Vaccine Trials in Dengue-endemic Regions of South Asia
Condition: Dengue
MeSH terms: Dengue
Study type: Interventional

Summary: 
      The purpose of this study is to determine the incidence of dengue fever and to build capacity
      for dengue vaccine trials in dengue-endemic regions of South Asia.
    

Detailed description: 
      This study aims to estimate the burden of dengue illness in selected sites South Asia and to
      prepare sites for the conduct of future vaccine efficacy trials.

      Operational goals include:

        -  Build long-term collaboration with sites in dengue-endemic regions of South Asia where
           the incidence of clinical dengue illness can be studied.

        -  Establish dengue surveillance cohorts that can be followed long-term.

        -  Establish operational feasibility of future Phase III studies with regard to
           recruitment, case capture and sampling procedures.

        -  Prepare sites for participation in Phase III clinical endpoint studies.
    

Intervention name(s): Blood sample collection
Intervention type(s): Procedure
Intervention description(s): Blood samples will be collected during the Suspected Dengue First Visit. All study subjects with AFI (fever [body temperature ≥ 38°C/≥ 100.4°F] on ≥ 2 consecutive calendar days, measured at least twice, at least 8 hours apart) should be seen at a designated study hospital/clinic by the study physician. The Suspected Dengue First Visit should be scheduled within 7 days from the onset of fever (Days 2-7) and should ideally take place on the second day of fever (Day 2).
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Dengue; Non-laboratory confirmed dengue (non-LCD); Acute febrile illness (AFI); Laboratory confirmed dengue (LCD)
MCE Direct Visualization of Drug Behavior in Upper-gastrointestinal Tract
Condition: Capsule Endoscopy
Study type: Observational

Summary: 
      The investigators aim to explore the feasibility of MCE in direct, real-time visualization of
      drug behavior in upper-gastrointestinal tract, which presented by the adhesion, distribution,
      and dissipation characteristics of dyed sucralfate gel.
    

Detailed description: 
      This pilot study was a prospective, single-centered, nonrandomized study. The investigators
      selected 10 subjects from patients with a recent history of upper-gastrointestinal symptoms
      who met the indication of taking sucralfate suspension gel, and another 10 subjects from
      healthy volunteers.

      Procedures were performed by the NaviCam magnetic capsule guidance system. To enhance
      discrimination, the sucralfate gel dyed with 0.3 ml methylene blue. The subjects swallowed
      the capsule with water in the left lateral position. When capsule enter stomach cavity,
      subject was asked to sit up and ingested 4 g aerogenic powder with 5 ml water to distend the
      stomach, and performed gastric baseline examinations to identify the lesions. After baseline
      examination, subjects ingested dyed sucralfate gel and performed the first-time examination.
      The examination was repeated at 30 min intervals, until dyed sucralfate gel disappeared
      completely. When study completed, the capsule was detached from string and continued into the
      small bowel for further examination.

      The endoscopists recorded the adhesion and dissipation times of dyed sucralfate gel,
      calculated the efficient time, and selected the images of six primary anatomic landmarks from
      each examination to measure the distribution area (%) . Any complication or discomfort during
      the procedure was evaluated. The discomfort was scored on a scale from 0 to 3 (0 = no; 1 =
      mild/minimal; 2 = moderate; 3 = sever/very difficult).
    

Intervention name(s): Magnetically controlled capsule endoscopy
Intervention type(s): Device
Intervention description(s): The subjects swallowed the capsule with water in the left lateral position. When capsule enter stomach cavity, subject was asked to sit up and ingested 4 g aerogenic powder with 5 ml water to distend the stomach, and performed gastric baseline examinations to identify the lesions. After baseline examination, subjects ingested dyed sucralfate gel and performed the first-time examination. The examination was repeated at 30 min intervals, until dyed sucralfate gel disappeared completely.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Volunteers who agreed to participate in the feasibility examination of MCE direct
        visualization of sucralfate gel behavior in fasted stomach.
      
Keywords: Magnetically controlled capsule endoscopy; sucralfate gel; drug behavior; upper-gastrointestinal tract
Cognitive Behavioral Therapy for Hyperacusis
Condition: Hyperacusis
MeSH terms: Hyperacusis
Study type: Interventional

Summary: 
      The main purpose of this study is to investigate whether cognitive behaviour therapy (CBT)
      can be useful for people suffering from Hyperacusis.

      Also, the investigators are interested in investigating this group of patients on psychiatric
      and somatic comorbidity, personality traits, and startle response to sounds.

      The investigators will also study the audiological measures commonly used in Sweden to
      measure hyperacusis, and investigate their validity.

      The investigators hypothesize that CBT might be helpful for patients suffering from
      Hyperacusis.
    

Detailed description: 
      Hyperacusis, defined as unusual intolerance to ordinary environmental sounds, is a common
      problem for which there are no controlled trials on psychological treatment. Given the
      avoidance strategies present in hyperacusis, and similarities with problems such as tinnitus
      and chronic pain, cognitive behaviour therapy (CBT) is hypothesized to be helpful for
      patients with hyperacusis. In this randomized controlled study of 60 patients with
      hyperacusis, CBT was compared with a waiting list control group using the Loudness Discomfort
      Level test (LDL), the Hyperacusis Questionnaire, the Hospital Anxiety and Depression Scales,
      the Quality of Life Inventory and an adapted version of the Tampa Scale of Kinesiophobia.
      There were significant between-group effects in favour of the CBT group on all measures
      except for the HADS anxiety scale. Between-group effect sizes were moderate to high, with
      Cohen's d = 0.67 and 0.69 per ear, respectively, for the primary measure LDL, and ranging
      from d = 0.32 to 1.36 for the secondary measures. The differences between groups ceased to
      exist when the waiting list group was treated later with CBT, and the treatment results were
      largely maintained after 12 months. In conclusion, CBT is a promising treatment for
      hyperacusis, although more research is necessary.
    

Intervention name(s): Cognitive behavioural therapy
Intervention type(s): Behavioral
Intervention description(s): 6 sessions by licensed psychologist, including psychoeducation, exposure therapy, applied relaxation and behavioral activation.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Hyperacusis; Personality; Comorbidity; Treatment; Cognitive behavioral therapy
Frontline Therapy in de Novo Multiple Myeloma Patients Under 65
Condition: Multiple Myeloma
MeSH terms: Multiple Myeloma; Neoplasms, Plasma Cell
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this Phase 2 study is to evaluate the efficacy and safety of treatment with
      bortezomib, lenalidomide and dexamethasone in patients with untreated multiple myeloma. This
      study will evaluate whether the addition of lenalidomide to bortezomib and dexamethasone will
      increase the Complete Response (CR)/ very good partial response (VGPR) rate before and after
      High Dose Therapy (HDT) with ASCT.
    

Detailed description: 
      Patients will receive 3 induction cycles of bortezomib, lenalidomide and dexamethasone (VRD)
      followed by high dose melphalan and autologous stem cell transplantation. Two months after
      haematological recovery, patients will receive 2 consolidation cycles of VRD and maintenance
      therapy for 1 year with lenalidomide
    

Intervention name(s): Lenalidomide, Bortezomib
Intervention type(s): Drug
Intervention description(s): Induction:
3 cycles of 21 days of Dexamethasone : 40 mg/j, days 1, 8 et 14 Bortezomib (Velcade®) : 1,3 mg/m2/d, days 1, 4, 8, et 11 Lenalidomide (Revlimid®) :25 mg/d, days 1 to 14
Consolidation (2 months After ASCT):
2 cycles of 21 days of Lenalidomide (Revlimid®) 25 mg/j, days 1 à 14 Bortezomib (Velcade®) 1,3 mg/m2/d, days 1, 4, 8, et 11 Dexamethasone 40 mg/j, days 1, 8 et 14
Maintenance Phase:
3 to 8 weeks after consolidation. Cycle length: 28 days Lenalidomide (Revlimid®) 10 mg/d until 12 months
Other intervention name(s): Lenalidomide (REVLIMID®); Bortezomib (VELCADE®)
Intervention MeSH terms: Lenalidomide; Bortezomib
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: De novo Multiple Myeloma; Bortezomib; Lenalidomide; induction therapy; consolidation therapy; maintenance therapy; High dose therapy; frontline therapy including new drugs and high dose therapy
The Effects of Moxibustion on Ulcerative Colitis
Condition: Ulcerative Colitis
MeSH terms: Colitis; Colitis, Ulcerative; Ulcer
Study type: Interventional

Summary: 
      To investigate the mechanism and effects of moxibustion on patients with ulcerative colitis.
    

Detailed description: 
      A total of 60 patients with UC were randomly divided into the following 2 groups: a)
      Herb-partition moxibustion (Treatment Group) and b) Sham herb-partition moxibustion (Control
      Group). All patients in the trial will be treated with moxibustion 3 times a week, once a day
      for 30 minutes, for a total of 12 weeks. MRI will be used to observe the changes on brain
      structure and function in patients with UC, and further research on the characteristics of
      the brain nerve response of these patients with herb-partition moxibustion. In addition,
      tissue morphology and molecular biology tests will be conducted to observe the regulation and
      expression of VDR and antimicrobial peptides in the intestinal mucosa of UC patients. All
      these steps will be done in order to provide experimental basis for the mechanism of the
      effects of herb-partition moxibustion in the treatment of UC.
    

Intervention name(s): Herb-partitioned moxibustion; Sham herb-partitioned moxibustion
Intervention type(s): Other; Other
Intervention description(s): Patients receive herb-partition moxibustion 3 times a week, once a day for 30 minutes, for a total of 12 weeks.; Patients receive sham herb-partition moxibustion 3 times a week, once a day for 30 minutes, for a total of 12 weeks.
Other intervention name(s): Treatment Group; Control Group
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Home Exercise Telerehabiliation for MS
Condition: Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Sclerosis
Study type: Interventional

Summary: 
      The primary purpose of this study is to evaluate the effects of an individualized
      telerehabilitation program on mobility, fatigue, and quality of life for Veterans with MS.
      The secondary purpose was to assess adherence to exercise recommendations and overall
      satisfaction with the intervention.
    


Intervention name(s): Telerehabilitation; Standard treatment
Intervention type(s): Other; Other
Intervention description(s): Participants complete a standard physical therapy evaluation in-person. They are then provided telerehabilitation equipment for the telerehabilitation intervention. This intervention utilizes an Xbox Kinect sensor and tablet-based exercise software called Jintronix. The Jintronix exercise library includes an array of exercise activity options for varying functional levels. Exercise activities could be completed in sitting or standing postures and includes activities which focused on active range of motion, strength, balance, or calisthenic movements. Each activity requires the participant to complete a goal-directed game or replicate movements of an on-screen avatar. The therapist will adjust and progress the home exercise program using information provided by the Jintronix and the participant's verbal reports during clinical video teleconferencing. At the end of the intervention, the therapist will complete in-person discharge assessments.; Participants complete standard in-person physical therapy evaluation, follow-up, and treatment. Therapeutic exercise and activities will be prescribed to participants to perform at home between standard follow-up treatment appointments. At the end of the intervention, the physical therapist will complete in-person discharge assessments.
Intervention model: Single Group Assignment
Intervention model description: An experimental and control group will be utilized. The experimental group will perform the telerehabilitation intervention.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: multiple sclerosis; rehabilitation; telerehabilitation; telehealth; veteran health; physical therapy
Blood Flow Restriction Following ACL Reconstruction
Condition: Anterior Cruciate Ligament Rupture
MeSH terms: Rupture
Study type: Interventional

Summary: 
      The main objective is to determine the impact of Blood Flow Restriction (BFR) therapy, in
      comparison to a standard rehabilitation protocol, on preventing atrophy, improving quadriceps
      strength and improving functional outcomes of patients recovering from ACL reconstruction.
      The investigators hypothesize that patients undergoing BFR therapy after ACL reconstruction
      surgery will have better functional outcomes than those undergoing normal rehabilitation
      without BFR therapy.
    

Detailed description: 
      Recovery from anterior cruciate ligament (ACL) reconstruction involves early physical therapy
      to promote muscular development. Traditional training regimens are based on the concept that
      muscle growth is induced with high resistance exercises of at least 65-70% of 1-repetition
      maximum. Achieving a high resistance level can be challenging in the early post-surgical
      patient who may be limited by pain, muscle atrophy, diminished proprioception, and
      psychological factors. Increasing evidence has suggested that Blood Flow Restriction (BFR) in
      resistance training, while transmitting a decreased load (25-50% of 1-repetition maximum)
      across the surgical site, may provide an additional benefit of inducing muscular development
      similar to that of high intensity exercises .

      Augmenting exercises with BFR involves an external pressure cuff applied to the proximal
      portion of the extremity, which is inflated to a pressure that restricts venous outflow while
      allowing arterial inflow to continue. This creates a physiologic environment for the patient
      to gain the hypertrophic effect of high resistance training, though at a lower and safer
      intensity. Studies suggest that BFR stimulates muscular development through an increase in
      metabolic stress, muscle fiber recruitment, cell swelling, and protein synthesis.
    

Intervention name(s): Blood Flow Restriction Therapy; ACL Reconstruction rehabilitation
Intervention type(s): Device; Other
Intervention description(s): A wide pressure cuff will be applied to the upper thigh prior to starting strengthening exercises. The cuff is inflated to 80% of resting systolic blood pressure. The cuff remains inflated for the entirety of the exercise (4 sets of a specific movement). Once the exercises are completed, it is deflated for a minimum of one minute before the next type of exercises are started.; post-operative rehabilitation according to current standards of care
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: BFR; ACL; rehabilitation
Bioequivalence Study of Topiramate Tablets 25mg Under Fasting Conditions
Condition: Healthy
Study type: Interventional

Summary: 
      The objective of this study was to compare the single-dose relative bioavailability of
      Ranbaxy and Ortho-McNeil Pharmaceutical (Topamax®) 25 mg topiramate tablets following a 50 mg
      dose under fasting conditions.
    

Detailed description: 
      This was an open-label, randomized, single-dose, 2-way crossover, relative bioavailability
      study performed on 24 healthy adult male volunteers and 4 alternates. All 28 subjects
      completed the clinical phase of the study. In each period, subjects were housed from the
      evening before dosing until after the 24-hour blood draw. Subjects were to return for the
      48-, 72-, 96- and 120-hour blood draws. Both periods were separated by a washout period of 14
      days.
    

Intervention name(s): Topiramate
Intervention type(s): Drug
Intervention description(s): 25mg Tablets
Intervention MeSH terms: Topiramate
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: Topiramate fasting study
Effects of Yoga on Bone Metabolism in Premenopausal Women
Condition: Bone Health; Osteoporosis
MeSH terms: Osteoporosis
Study type: Interventional

Summary: 
      This study examined the effects of 8 months of Yoga training on bone density and bone
      turnover markers in premenopausal women, ages 35-50 years. The style of Yoga used was power
      Yoga that involved postures with a jumping component. The investigators hypothesized that the
      Yoga intervention would result in beneficial improvements in bone turnover markers, by
      increasing the bone formation marker and decreasing the bone resorption marker.
    


Intervention name(s): Yoga Group
Intervention type(s): Other
Intervention description(s): 8 months of Yoga training
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Yoga; Bone turnover markers; Bone strength; Bone mineral density
The Role of Fatty Acids in Vaccine Efficacy
Condition: Rabies Vaccination Reaction
MeSH terms: Rabies
Study type: Interventional

Summary: 
      This study intends to use a randomized controlled trial design to vaccinate all participants
      against rabies and perform ARA interventions during vaccination to test the efficacy, safety,
      and intestinal flora of each group after immunization.
    

Detailed description: 
      Rabies is an acute zoonotic infectious disease caused by central nervous system invasion by
      rabies virus. At present, there is still a lack of effective treatment, and once clinical
      symptoms appear, it is almost 100% fatal. Rabies vaccination within 24 hours of exposure may
      reduce the incidence of rabies. Pre-exposure prophylaxis is also effective, and the current
      recommended pre-exposure vaccination program in China is 0 days, 7th day, 21st days.

      The health of the human body is inseparable from various nutrients. There are studies
      suggesting that arachidonic acid(ARA) has an immunomodulatory effect, but there is limited
      evidence for its effect on vaccines. Therefore, this study will explore the effects of
      nutritional supplements on the effectiveness of rabies vaccination.
    

Intervention name(s): Arachidonic acid; Sunflower oil; Rabies Vaccine (Vero Cell) for Human Use
Intervention type(s): Dietary Supplement; Dietary Supplement; Biological
Intervention description(s): D3 ARA group will receive ARA capsules from the third day of the study. D6 ARA group will receive ARA capsules from the sixth day of the study; The placebo group and D6 ARA group will receive sunflower oil capsules from the third day of the study. D6 ARA group will stop receiving sunflower oil capsules from the fifth day of the study.; Every participant will receive three doses of rabies vaccination.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Rabies Vaccination; Arachidonic acid; efficacy