bioihbjkbjnl/mcl2 huggingface dataset:
Study of Frontline Dasatinib Plus Chemotherapy in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (PH+ALL)
Condition: Philadelphia Positive Acute Lymphoblastic Leukemia
MeSH terms: Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Lymphoid; Philadelphia Chromosome
Study type: Interventional
Phase: Phase 2

Summary: 
      The current standard treatment approach for young patients with Positive Acute Lymphoblastic
      Leukemia (Ph+ALL) is the combination of a chemotherapy protocol employing four to five
      cytotoxic agents typically used for ALL together with imatinib. It is recommended to propose
      allogeneic Standard Induction and Consolidation Therapy (SCT) to all eligible patients with a
      suitable donor and to continue imatinib with or without additional therapy in patients not
      undergoing SCT.

      This protocol is a study for newly diagnosed Philadelphia chromosome positive acute
      lymphoblastic leukemia in patients aged 18 to 55 years.

      The objective of this strategy is to improve the overall results in the treatment of adult
      ALL with the addition of specific molecules to the common chemotherapeutic schedule.
    

Detailed description: 
      In the present study, the potent ABL tyrosine kinase inhibitor, Dasatinib will be added to
      standard induction and consolidation chemotherapy for the Philadelphia positive chromosome
      sub-group of ALL patients aged 18 to 55 years.

      The Study hypothesis is, that Dasatinib in combination with standard chemotherapy according
      to GMALL protocol 07/2003 is feasible and induces cytologic and molecular remission rates
      comparable to chemotherapy in combination with imatinib without increased treatment-related
      mortality.
    

Intervention name(s): Dasatinib
Intervention type(s): Drug
Intervention description(s): Dasatinib p.o. + Chemotherapy (Dexamethasone, Cyclophosphamide, Vincristine, Methotroxate, 6-Mercapto-Purine, Cytarabine, Vindesine, VP16 (Etoposide))
Other intervention name(s): Sprycel (R); BMS-354825
Intervention MeSH terms: Dasatinib
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: philadelphia chromosome; BCR-ABL; ALL; acute lymphoblastic leukemia; dasatinib; Sprycel
Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures
Condition: Blood Loss; Anesthesia
MeSH terms: Hemorrhage
Study type: Interventional
Phase: Phase 4

Summary: 
      Sevoflurane is an FDA-approved anesthetic drug commonly used for anesthesia during second
      trimester abortion procedures. It has a few advantages, including ease of use by the
      anesthesia provider. However, the literature suggests that when used in doses higher than
      those used at Oregon Health & Science University (OHSU) and Lovejoy, it is associated with an
      increase in the risk of bleeding. The investigators study aims to test whether the lower dose
      used at OHSU and Lovejoy during second trimester abortion procedures causes any difference in
      blood loss, when compared to similar abortion procedures for which this drug is not used.
    

Detailed description: 
      This study seeks to examine the bleeding complications associated with use of sevoflurane in
      general anesthesia regimens for second trimester abortion procedures and assess anesthesia
      providers' use and beliefs regarding possible risks associated with newer inhalational agents
      such as sevoflurane in this setting. Participants' anesthesia will either be intravenous (IV)
      propofol, IV midazolam, IV fentanyl and nitrous oxide or this same regimen combined with
      sevoflurane during maintenance of anesthesia. Procedural outcomes, specifically those related
      to bleeding complications, including need to intervene for excess blood loss, will be
      recorded and analyzed to establish if such a relationship between use of sevoflurane and
      excess blood loss exists.
    

Intervention name(s): Sevoflurane; No Sevoflurane
Intervention type(s): Drug; Other
Intervention description(s): Subject receives Sevoflurane in addition to other standard of care drug regimens for anesthesia with this procedure.; Subject only standard of care drug regimens for anesthesia with this procedure.
Other intervention name(s): Ultane
Intervention MeSH terms: Sevoflurane
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Supportive Care
Keywords: Sevoflurane; anesthesia; abortion; blood loss
14.0- 3.0- 3.0- η Protein With Rheumatoid Arthritis
Condition: Disease Activity
MeSH terms: Arthritis; Arthritis, Rheumatoid
Study type: Observational [Patient Registry]

Summary: 
      Aim of work: to explore the potential association between serum 14.0-3.0-3.0- η protein level
      with disease activity and bone mineral density (BMD) in Egyptian patients with rheumatoid
      arthritis (RA).

      188 patients with RA and 192 matched controls were enrolled. The RA activity parameters were
      evaluated in RA patients. BMD was measured. Serum level of 14.0- 3.0- 3.0- η protein and
      IL_.6 were estimated for all participants by ELISA.
    

Detailed description: 
      A total of 200 RA patients were invited to be enrolled in this study. Patients were diagnosed
      as having RA by the 2010 European-league-against-Rheumatism- (EULAR) and
      American-College-of-rheumatology (ACR) classification criteria for RA. Patients were
      collected from the outpatient clinic of the Rheumatology and Rehabilitation Department,
      Mansoura University Hospital.

      All participants underwent detailed medical history taking as well as clinical examination.
      The medical records of all patients were carefully reviewed. Data collection included age,
      gender, past medical history, current and past drug intake. In RA patients, the disease
      duration, duration of the morning stiffness, tender joint count (TJC) and swollen joint count
      (SJC) were reported. The activity of RA was measured by disease activity score 28 (DAS.28)
      based on the erythrocyte sedimentation rate (ESR) level (DAS28-ESR) [19]. The intensity of
      perceived pain was assessed by the visual analog scale (VAS) 100-mm scale.

      Bone mineral density (BMD) was measured using dual energy X-ray absorptiometry (DEXA) at
      proximal femur for all participants who were categorized into normal, osteopenic, or
      osteoporotic according to the definition of the World Health Organization (WHO) of the
      recorded T score A commercially available human IL_.6 ELISA kit (GenProbe, Diaclone, France)
      was used to measure IL_.6 serum level following the instructions of the manufacturer.

      Serum level of 14.0- 3.0- 3.0- η protein was determined by ELISA for all participants,
    

Intervention name(s): Serum level of 14.0- 3.0- 3.0- η protein and IL_.6
Intervention type(s): Diagnostic Test
Intervention description(s): Serum level of 14.0- 3.0- 3.0- η protein and IL_.6 were estimated for all participants by ELISA.
Other intervention name(s): ELISA
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        RA patients were invited to be enrolled in this study. Patients were diagnosed as having RA
        by the 2010 European-league-against-Rheumatism- (EULAR) and
        American-College-of-rheumatology (ACR) classification criteria for RA
      
Keywords: Rheumatoid arthritis; osteoporosis; 14.0- 3.0- 3.0- η
Trial to Determine the Safety and Efficacy of Influenza Virus Vaccine, Trivalent, Types A & B, Live Cold- Adapted (CAIV-T) in Healthy Children Attending Day Care Centers
Condition: Influenza
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to determine the efficacy of the liquid formulation of CAIVT
      against culture confirmed influenza illness in healthy children aged at least 6 months and
      less than 36 months, attending day care centers in Europe. In addition, the trial provides
      the opportunity to investigate the effect of CAIV-T on acute otitis media, on healthcare
      resource utilization and economic resources.
    


Intervention name(s): CAIV-T; Placebo
Intervention type(s): Biological; Other
Intervention description(s): The total single-dose volume of 0.2 mL was administered intranasally with the spray applicator intended for commercial use (approximately 0.1 mL into each nostril).; A single dose of placebo volume of 0.2 mL was administered intranasally with the spray applicator intended for commercial use (approximately 0.1 mL into each nostril).
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double
Primary purpose: Prevention
Serratus Anterior Plane Block in Pediatric Patients
Condition: Anesthesia, Local
Study type: Interventional

Summary: 
      The aim of this work is to study the efficacy of ultrasound guided serratus anterior plane
      block in pediatric patients undergoing thoracic surgeries.

      It is a randomized controlled trial.
    

Detailed description: 
      It is a prospective randomized controlled study. It is designed to estimate and compare the
      analgesic effect of single shot serratus anterior plane block in pediatric patients
      undergoing thoracic surgeries with fentanyl infusion versus fentanyl infusion alone as the
      control group. Our primary outcome will be the total dose of intra-operative fentanyl
      boluses.

      Randomization will be achieved by using an online random number generator. Blindness will be
      achieved by patient codes which will be placed into sequentially numbered sealed opaque
      envelopes by a research assistant who is not involved in the study. A physician not involved
      in patient management will be responsible for opening the envelope and give the instructions
      contained within each envelope to the anaesthesiologist who is expert in doing the serratus
      anterior plane block in patients included within the block group. This expert
      anaesthesiologist will not be involved in collecting data but another anaesthesia doctor will
      be responsible for patient management and collecting the intraoperative and postoperative
      data.
    

Intervention name(s): Serratus Anterior Plan Block+ Fentanyl infusion; Fentanyl
Intervention type(s): Procedure; Drug
Intervention description(s): After induction of anesthesia, the patients will be put on the lateral position with the diseased side up. A linear ultrasound transducer will be placed in a sagittal plane over the mid-clavicular region of the thoracic cage.
Then counting down ribs till the fifth rib will be identified in the mid-axillary line. The following muscles will be identified overlying the fifth rib: the latissimus dorsi (superficial and posterior),teres major (superior) and serratus muscles (deep and inferior). Under complete sterile conditions, the needle (25 G needle) will be introduced in-plane with respect to the ultrasound probe targeting the plane superficial to the serratus anterior muscle. Then, 2 mg/kg of 0.25% bupivacaine will be injected with continuous ultrasound guidance. In addition to continuous fentanyl infusion; Continuous fentanyl infusion throughout the surgical procedure.
Other intervention name(s): Serratus Anterior Plan Block
Intervention MeSH terms: Fentanyl
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Serratus anterior plane block; Pediatric; Thoracotomy
The Effects of Zn-containing Granulate on Patient Morbidity and Wound Healing After Free Gingival Graft Surgery
Condition: Surgery
Study type: Interventional

Summary: 
      There is no study in the literature showing the effects of Zn on wound healing after free
      gingival graft (FGG) operation. The aim of this randomized clinical study was to compare the
      early healing results of the palatal wound after FGG harvesting by sterile hemostatic agent
      suturing or the use of surgical stent from thermoplastic Zn-containing granules which was
      prepared chairside.
    

Detailed description: 
      There are many studies reporting paresthesia, herpetic lesion, mucocele, excessive bleeding
      and severe postoperative pain after procedure.The highest pain level perceived in the palatal
      region after the FGG operation is experienced on the first day after the operation and
      decreases to the preoperative levels approximately 2 weeks after the operation. Although
      hemostatics, bioactive substances, antibacterial and antiseptic agents, herbal effective
      products, platelet concentrations, low-dose laser applications, palatal stents are used in
      the palatal region to accelerate the healing stages and prevent such complications, an ideal
      support has not been found.
    

Intervention name(s): Zn granulate stent after FGG surgery; Hemostatic agent suturing
Intervention type(s): Procedure; Procedure
Intervention description(s): Immediately after FGG harvesting from the palatal tissue, homeostasis was achieved by sterile wet gauzes and the ZnG was prepared according to the manufacturer guidelines. Briefly, approximately 10 grams of granulate was poured into hot water and then manually shaped to cover the surgical area. The retention was achieved from the palatal, occlusal and buccal surfaces of the teeth. The patient was asked to wear the ZnG for 7 days except for eating.(; Immediately after FGG harvesting from the palatal tissue, homeostasis was achieved by sterile wet gauzes. Then hemostatic agent containing cellulose were sutured on the palatal wound area with 4.0 vicryl sutures in this group. Sutures were removed after 7 days.
Intervention MeSH terms: Hemostatics
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: free gingival graft surgery; surgical stent; zinc; pain; bleeding
Effect of the LIVESTRONG at the YMCA Exercise Program on Cancer Related Outcomes in Cancer Survivors
Condition: Breast Cancer
Study type: Interventional
Phase: Phase 3

Summary: 
      The proposed study is a randomized trial evaluating the impact of the 12-week LIVESTRONG
      exercise program vs. waitlist control on cancer-related outcomes in 200 cancer survivors.
    

Detailed description: 
      The proposed study is a randomized trial evaluating the impact of the 12-week LIVESTRONG
      exercise program vs. waitlist control on cancer-related outcomes in 200 cancer survivors.
      Participants will undergo baseline testing at Dana-Farber or Yale, including administration
      of questionnaires to assess quality of life and the presence of cancer and treatment-related
      symptoms, fasting blood draw, and evaluation of body composition (using dual energy X-ray
      absorptiometry (DEXA). Participants will then take part in the 12-week LIVESTRONG Program or
      will be assigned to a wait-list control group. All measurements will be repeated at
      Dana-Farber or Yale after the 12-week exercise program or control period.
    

Intervention name(s): LIVESTRONG
Intervention type(s): Behavioral
Intervention description(s): The LIVESTRONG at the YMCA is a twelve-week, small group (< 16 participants) program designed for adult cancer survivors. YMCA fitness instructors work with each participant to fit the program to their individual needs. The instructors are trained in the elements of cancer, post rehabilitation exercise and supportive cancer care. There are two YMCA fitness instructors overseeing each exercise session. Each session is 90 min in duration, twice per week, for 12-wks (total of 24 sessions). Each session begins with a warm-up, then aerobic exercise (e.g., treadmill) and resistance training exercises, followed by a cool-down period, and follows the recommendations of the American College of Sports Medicine.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Body Composition; Exercise; Survivorship
Intraestromal Corneal Ring in Mild Keratoconus
Condition: Cornea; Eye Diseases; Keratoconus; Ophthalmological Disorder
MeSH terms: Eye Diseases; Keratoconus
Study type: Interventional

Summary: 
      To determine whether the implantation of an intrastromal corneal ring is an effective
      treatment for a homogeneous group of mild keratoconus patients.
    

Detailed description: 
      A group of 65 patients with mild keratoconus were implanted with a Ferrara ring in a single
      eye. Six months after surgery, the aberrations were measured and the visual function was
      determined using clinical indices. The aberrations, especially comatic aberration (coma),
      were measured independently.
    

Intervention name(s): Intraestromal corneal ring
Intervention type(s): Device
Intervention description(s): The patients underwent surgery to implant the intrastromal corneal ring (Ferrara Ophthalmics, Belo Horizonte, Brazil) using a manual technique. The procedures were performed by a single surgeon with extensive training in corneal surgery. All patients received the same ring, and the number (1 or 2 segments), thickness, and arc size were calculated using the nomogram provided by the manufacturer.
Other intervention name(s): Ferrara ring
Intervention model: Single Group Assignment
Intervention model description: Intraestromal corneal ring
Masking: None (Open Label)
Primary purpose: Treatment
Arthroscopic Coracoclavicular Ligament Reconstruction Comparing Two Techniques
Condition: AC Joint Dislocation
MeSH terms: Joint Dislocations
Study type: Interventional

Summary: 
      This study follows early wound healing using knot hiding titanium implants in
      coracoclavicular ligament reconstruction. A further aim is to compare two techniques where
      the semitendinosus tendon graft either runs through the coracoid drill hole or goes around
      the coracoid.
    

Detailed description: 
      A modified arthroscopic technique for coracoclavicular ligament reconstruction was used based
      on a previous technique where the supportive device and the semi tendon graft share the
      clavicular and coracoid drill holes. A notable problem with the previous technique was large
      protruding suture knots on the washer and clavicle, which could predispose to wound
      infection. In this new modified technique, new implants were introduced. The new implant
      hides the suture knot and less foreign material is needed.

      The purpose of this study is to follow the patients operated using the new implants with
      special attention to early clavicular wound healing. A further aim is to compare a technique
      where the semitendinosus graft runs through clavicular and coracoid drill holes versus a
      technique where the graft runs under the coracoid process.
    

Intervention name(s): Coracoclavicular ligament reconstruction
Intervention type(s): Procedure
Intervention description(s): Arthroscopically conducted ligament reconstruction for the treatment of an AC dislocation
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Prospective randomized follow-up study. Two groups.
Masking: Single (Investigator)
Primary purpose: Treatment
Low-Carbohydrate Diet Intervention on Body Weight
Condition: Over Weight; Obesity
MeSH terms: Overweight; Body Weight
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      -  The primary aim of this study is to determine the adherence of low- carbohydrate among
           Chinese.

        -  Then compare the effect of low-carbohydrate and traditional Chinese but
           restricted-calories diet on weight loss and metabolic traits.
    

Detailed description: 
      Obesity is a well established risk factor for type 2 diabetes mellitus, hypertension,
      dyslipidemia and cardiovascular disease. Along with rapid nutritional and lifestyle
      transition featured as increased energy dense diet intake and reduced physical activity, the
      prevalence of obesity has reached epidemic level and affected more than 70 million Chinese
      adults nowadays. Previous studies suggested that low-carbohydrate diet was an effective and
      safe way to lose weight and had potential benefit on lipids profiles. However, it is still
      unknown whether this diet can be feasible to control the epidemic of obesity and its related
      metabolic diseases among Chinese, whose carbohydrate consumption contribute approximately 55%
      of total energy intake.

      Therefore, the aim of this pilot study is to investigate the adherence and effectiveness of
      two weight-loss diets among Chinese. This will be a randomized, controlled clinical trial. A
      total of 50 overweight or obese nurse assistants will be randomly assigned to receive a
      low-carbohydrate diet or a traditional high-carbohydrate Chinese but restricted-calories diet
      for 12 weeks. The adherence of study protocol and effects of the two diets on body weight,
      waist circumference, body fat, fasting glucose and lipid profile will be evaluated.
    

Intervention name(s): low carbohydrate diet; Calories restricted diet
Intervention type(s): Other; Other
Intervention description(s): Dietary carbohydrate diet was restricted to 20 gram/day within the first week, then increase gradually to 120 gram/day; Total energy intake is restricted to 1200 kcal/day for women. Energy from carbohydrate, protein and fat will be kept to approximate 55%, 20% and 25%, respectively. Moreover, saturated fat and dietary cholesterol are restricted to at most 10% energy and 300 mg/day, respectively
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: over weight; obesity