bioihbjkbjnl/mcl2 huggingface dataset:
Exercise and the Receptor for Advanced Glycation End Products (RAGE)
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      This study examines the effects of 12-weeks of aerobic exercise training on the mechanisms
      driving RAGE-mediated inflammation in type 2 diabetic humans.
    

Detailed description: 
      Activation of RAGE (receptor of advanced glycation endproducts (AGEs)), via binding of AGEs
      and other ligands, modulates the development and progression of diabetic complications
      through persistent and cyclic activation of nuclear factor-kappa beta. Targeting RAGE
      directly as a therapeutic strategy has largely been unsuccessful. However, RAGE signaling can
      be interrupted, in vivo, by ADAM10 (a disintegrin and metalloproteinase 10) directed
      proteolytic cleavage of the RAGE ectodomain, and thus creating a soluble isoform of RAGE
      (sRAGE) that is released from the cell and appears into the circulation. Maintaining high
      levels of circulating sRAGE is advantageous as sRAGE will sequester RAGE ligands and prevent
      RAGE cell signaling.

      Although the exact mechanisms of ADAM10 mediated RAGE release remain undefined, calcium
      related and other signaling (SIRT1) impact ADAM10. Aerobic exercise presents a unique model
      for mechanistic study of RAGE release as muscle contraction induces robust calcium signaling,
      activates SIRT1, and provides stimuli for tissue remodeling and resolution of the metabolic
      profile that drives inflammation.
    

Intervention name(s): Aerobic Exercise
Intervention type(s): Behavioral
Intervention description(s): 12-week supervised aerobic exercise
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: RAGE; ADAM10; Exercise; sRAGE
Healthy Activities for Prize Incentives
Condition: Substance Abuse; HIV Infections
MeSH terms: Substance-Related Disorders
Study type: Interventional

Summary: 
      In this Stage 1 therapy development project, we plan to develop, formalize, and derive effect
      size estimates of a contingency management (CM) therapy that focuses on improving health,
      especially as related to increasing low intensity physical activities, such as walking,
      resistance training, and stretching. The Healthy Activities for Prize Incentives (HAPI)
      intervention will be targeted toward and tested within HIV-positive substance abusers who
      attend HIV drop-in centers. After initial therapy development in a Stage 1a pilot project
      with 9 patients, the therapy manuals and materials will be adapted and refined. In a Stage 1b
      controlled trial, we will recruit and randomize 70 substance abusing HIV-positive patients to
      (a) HAPI plus 12-step facilitation therapy or (b) contingency management for abstinence plus
      12-step facilitation therapy. Each intervention will consist of one weekly individual therapy
      session for 16 weeks. All participants will provide urine and breath specimens twice weekly
      that will be tested for opioids, cocaine, methamphetamine, marijuana and alcohol. Patients in
      both conditions will earn the chance to win prizes for submitting drug-negative specimens,
      and those randomized to the HAPI condition will also earn the chance to win prizes for
      engaging in healthy activities. Physical activity levels, drug use, psychological symptoms,
      and subjective and objective indicators of health (body mass index, waist circumference,
      blood pressure, viral load) will be measured pre-treatment and at months 2 and 4
      (post-treatment), as well as at a 7-month (3 months after treatment) follow-up evaluation.
      Compared to those receiving 12-step facilitation with contingency management for abstinence,
      we expect that those in the HAPI condition will participate in more physical activities,
      decrease drug use to a greater extent, evidence reduced depression, and show trends toward
      improvements in health indices. If effect sizes in at least the small to medium range are
      noted across all domains, we will consider the therapy appropriate for further evaluation in
      a Stage 2 therapy development study.
    


Intervention name(s): contingency management; contingency management
Intervention type(s): Behavioral; Behavioral
Intervention description(s): contingency management for abstinence plus 12-step facilitation therapy
prizes awarded for target behaviors; contingency management for abstinence plus 12-step facilitation therapy and contingency management for completing healthy activities
prizes awarded for target behaviors
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Substance Abuse; HIV; Contingency Management; Physical Activity
Short-term Effect of Pomegranate Juice on Blood Sugar and Its Controlling Hormones in Pre-diabetic and Type II Diabetic Patients.
Condition: Patients With Type 2 Diabetes (FSG: More Than 7.1 and Not Higher Than 15.8 mmol/L)
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      Fresh pomegranate juice at 1.5 mL/kg of body weight was administered by recruited healthy
      individuals and patients with type 2 diabetes of fasting serum glucose between 7.1 and 15.8
      mmol/L after approximately 12 hours fasting. Blood samples were collected in plain tubes
      before (-5 minutes) and at 1 and 3 hours after drinking pomegranate juice. Blood samples were
      centrifuged and serum was collected and stored for glucose and hormonal analysis. Patients
      were recruited from those of earlier stages of type 2 diabetes, and many of them already
      drink pomegranate juice as of its benefits for their health).

      The exclusion criteria included subjects with renal or hepatic disease, pregnancy, treatment
      with insulin, and hormone therapies. Participants who had either smoked cigarettes or taken
      antioxidant supplements, lipid-lowering drugs, and oral hypoglycemic agents, such as
      metformin (glucophage) or sulfonylureas, within the preceding 12 hours were also excluded.

      The study was explained to all of the recruited subjects by the clinical researchers, and
      written informed consent was obtained prior to enrollment. Approval for the study was
      provided by the IRB Committee at Jordan University of Science and Technology (Irbid, Jordan).
    


Intervention name(s): Fresh pomegranate juice
Intervention type(s): Other
Intervention description(s): Pomegranate seeds (arils) were separated by hand, and fresh pomegranate juice was prepared by squeezing the seeds using a fruit squeezing machine. Fresh pomegranate juice was given at 1.5 mL/kg of body weight for the fasted recruited patient with type 2 diabetes (FSG < 15.8 mmol/L). Blood was collected before and after 1 and 3 hours of ingesting the juice.
Allocation: Randomized
Intervention model: Single Group Assignment
Intervention model description: A Patient with type 2 diabetes ( < 15.8 FSG) and healthy individual ingested fresh pomegranate at 1.5 mL per kg of body weight after approximately 12 hours fasting. Blood samples were collected before (- 5 min) and after 1 and 3 hours of ingesting pomegranate juice.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Patients with type 2 diabetes; Fresh pomegranate juice; Fasting serum glucose
Single-Ascending-Dose Study of BIIB076 in Healthy Volunteers and Participants With Alzheimer's Disease
Condition: Alzheimer's Disease; Healthy Volunteer
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of the study is to evaluate the safety and tolerability of
      single-ascending intravenous (IV) infusions of BIIB076 in healthy volunteers and participants
      with Alzheimer's disease (AD). A secondary objective of the study for both healthy volunteers
      and participants with AD is to assess the serum pharmacokinetic(s) (PK) profile of BIIB076
      after single-dose administration. Another secondary objective is to evaluate the
      immunogenicity of BIIB076 in serum after single-dose administration.
    


Intervention name(s): BIIB076; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Administered as single intravenous (IV) infusion; Administered as single IV infusion
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Efficacy and Ventilatory Responses to VHI in Atelectasis Patients
Condition: Atelectasis
MeSH terms: Pulmonary Atelectasis
Study type: Interventional

Summary: 
      The purpose of this study include (1) To investigate the efficacy of ventilator
      hyperinflation technique to re-expand lung atelectasis on patients with critical trauma who
      intubated and mechanical ventilation in the intensive care unit, (2) To investigate the
      effectiveness of ventilator hyperinflation technique to improve airway clearance on patients
      with critical trauma in the intensive care unit, and (3) To explore the acute responses of
      ventilatory functions to ventilator hyperinflation technique on patients with critical trauma
      who intubated and mechanical ventilation in the intensive care unit.
    


Intervention name(s): Ventilator hyperinflation technique; Conventional treatment
Intervention type(s): Procedure; Procedure
Intervention description(s): Hyperinflation using a ventilator or "ventilator hyperinflation technique (VHI)" was developed from the manual hyperinflation (MHI) technique. There is no need to disconnect the patient when using the VHI technique and consequently there is no loss of PEEP and little or no risk of the adverse effects associated with MHI.; Conventional treatments are the routine treatment that patients were received from the physical therapist who take care them. The routine treatments are consist of chest physical therapy techniques (i.e. vibration, positioning, etc.) and others treatment (i.e. passive movement).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: lung collapse; ventilator hyper inflation; hemodynamic responses; ventilatory responses; trauma patients
Study Comparing High-Dose Flu Vaccine to Standard Vaccine in Cancer Patients Less Than 65 Receiving Chemotherapy
Condition: Cancer; Influenza Viral Infections
MeSH terms: Influenza, Human; Virus Diseases
Study type: Interventional
Phase: Phase 2

Summary: 
      The safety and immunogenicity of high dose influenza vaccine has not been studied in young
      patients receiving chemotherapy. This study will evaluate and compare the immunogenicity and
      safety of high dose influenza to standard dose influenza vaccine in adult oncology patients
      who are younger than 65 years old receiving chemotherapy.
    


Intervention name(s): Standard Trivalent Influenza Vaccine; High-Dose Influenza Vaccine
Intervention type(s): Biological; Biological
Intervention description(s): Each 0.5 mL dose contains influenza split virus antigens formulated to contain a total of 45 mcg of influenza virus hemagglutinin, 15 mcg each from the 3 influenza virus strains in the vaccine.One dose given per patient.; Each 0.5 mL dose of Fluzone High-Dose contains influenza split virus antigens that are formulated to contain a total of 180 mcg of influenza virus hemagglutinin, 60 mcg each from the 3 influenza virus strains in the vaccine. One dose given per patient.
Other intervention name(s): Fluzone; Fluzone High-Dose
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Prevention
Keywords: Influenza vaccine; Oncology; Chemotherapy
The Effects of Swimming on Elderly Women With Stage-2 Hypertension
Condition: Menopause; Hypertension
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      Aging is associated with progressive decreases in arterial health and function as well as
      overall fitness. It is crucial to prevent or reduce the negative effects of aging on the
      vasculature and fitness components by implementing appropriate lifestyle interventions, such
      as exercise training. We examined the effects of a swimming (SWM) regimen on arterial
      stiffness (pulse wave velocity, PWV), blood pressure (BP), wave reflection (AIx), muscle
      strength and aerobic capacity in elderly women with stage 2 hypertension.
    

Detailed description: 
      Using a parallel experimental design, participants were randomly assigned to either SWM
      (n=52) or non-exercising control group (n=48) for 20 weeks. Participant in the SWM group
      trained 3-4 days/week, progressing in duration from 25 to 45 min. Participants' carotid to
      radial PWV (crPWV), systolic and diastolic BP, AIx, strength and VO2max were measured at
      baseline and after 20 weeks of their assigned intervention.
    

Intervention name(s): Swimming
Intervention type(s): Behavioral
Intervention description(s): This group completed 20-weeks of swimming
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Swimming; Arterial Stiffness; Blood Pressure; Muscular Strength; Cardiorespiratory Endurance
A Multicentre Trial to Determine the Efficacy and Safety of AD-337 in the Treatment of Fibromyalgia
Condition: Fibromyalgia
MeSH terms: Fibromyalgia; Myofascial Pain Syndromes
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a multicentre, randomized, double-blind, placebo controlled, parallel group
      exploratory study to investigate the efficacy, safety and tolerability of AD 337 in the
      treatment of fibromyalgia in female subjects.
    


Intervention name(s): AD 337
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: ACR 1990 Fibromyalgia; Fibromyalgia Impact Questionnaire
Efficacy and Safety of IQP-AK-102 in Reducing Appetite
Condition: Appetite Regulation; Appetite Suppression; Energy Intake
Study type: Interventional

Summary: 
      The primary cause of being overweight is an imbalance in calories consumed and energy
      expenditure. A surplus in energy intake might result in body fat deposition and thereby body
      weight gain. Therefore, food intake regulation is crucial to control the body weight gain.

      Appetite regulation plays an important role in determining the food intake, which is a
      complex process influenced by the individual (physiology and psychology) and environment.
      Satiation (process that leads to the termination of eating) and satiety (decline in hunger,
      increase in fullness after a meal has finished) are the precursors of appetite regulation,
      which may be induced by various food components such as macronutrients, water, alcohol and
      non-digestible polysaccharides. High viscosity and swellable/bulking food components such as
      dietary fibre are expected to elicit stronger satiation/satiety than the macronutrients or
      clear liquid. Due to its unique physicochemical properties, dietary fibre has been recognized
      as potential ingredient that helps to enhance the sensation of satiety in the upper gut by
      increasing gastric distension and delaying gastric emptying, which subsequently reduces the
      food intake.

      IQP-AK-102 comprises of a proprietary blend of dietary fibres known to promote a feeling a
      fullness. The objectives of this study are to evaluate the efficacy and safety of IQP-AK-102
      on appetite reduction in overweight subjects during a 4-weeks interval.
    


Intervention name(s): IQP-AK-102
Intervention type(s): Device
Intervention description(s): IQP-AK-102 has been qualified as a medical device (CE certificate has been ob- tained), class IIb, according to MDD 93/42/EEC, annex IX, rule 5.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Safety of Tuberculosis Vaccine, MVA85A, Administered by the Aerosol Route and the Intradermal Route
Condition: Tuberculosis
MeSH terms: Tuberculosis
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a phase I trial to compare the safety and immunogenicity of candidate TB vaccine
      MVA85A administered by the aerosol inhaled route and the intradermal route in healthy
      BCG-vaccinated adult subjects.
    


Intervention name(s): Aerosol inhaled MVA85A; Intradermal MVA85A
Intervention type(s): Biological; Biological
Intervention description(s): Aerosol inhaled MVA85A 1 x 10^7 pfu and intradermal saline placebo; Intradermal MVA85A 1 x 10^7 pfu and inhaled aerosol saline placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: vaccine; immunogenicity
We Experience: Perspectives on a Quality Abortion Care Experience: A Patient Centered Approach
Condition: Pregnancy Termination
Study type: Observational

Summary: 
      The purpose of this study is to determine aspects of abortion care most important to the
      patient in creating a "high quality" abortion experience, to investigate patients'
      expectations of abortion care, and to explore provider perceptions of patients' abortion
      experiences and assess concordance with patients' perspectives.
    

Detailed description: 
      The purpose of this study is to determine aspects of abortion care most important to the
      patient in creating a "high quality" abortion experience, to investigate patients'
      expectations of abortion care, and to explore provider perceptions of patients' abortion
      experiences and assess concordance with patients' perspectives.

      The investigators will conduct semi-structured interviews with patient participants and
      providers separately to determine patients' expectations of abortion care as well as the most
      important aspects of the abortion experience and to explore providers' perceptions of their
      patients' abortion experience and assess concordance.
    

Intervention name(s): Patient Interview; Provider Interview
Intervention type(s): Other; Other
Intervention description(s): Patient intervention includes a 30 minute interview prior to their abortion procedure and a follow up phone-interview that will be 10-minutes and held 24-72 hours from the procedure.; For physician participants, providers will be interviewed after completion of the patient's visit and this will be 10-15 minutes.
Observational model: Other
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        Patient Participants: Women presenting to Center for Reproductive Health (CRH) for induced
        abortion for an undesired pregnancy in the first trimester < 14 weeks and age 18-45 years.
        Woman must have a completed surgical abortion procedure and be able to speak English or
        Spanish.

        Provider Participants: Providers must be performing procedures on the day patient
        participants are recruited and must be willing to give their perspective on the
        participating patients' abortion experience.
Dietary Variety Versus Dietary Fat Effects in Energy Intake
Condition: Healthy
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The relative importance of dietary patterns vs. macronutrient composition in affecting energy
      intake and body weight remains uncertain. In this study we propose to investigate the
      relative effects of dietary variety vs dietary fat on voluntary energy intake in adults. We
      will quantify and compare the effects of typical ranges of variety & fat intakes in the
      American diet on voluntary energy intake. The primary hypotheses to be tested are 1)an
      increasing availability of entree/side/snack/dessert variety offered will significantly
      increase voluntary energy intake in a dose-response fashion when other dietary factors known
      to influence energy intake are held constant. 2)The separate effects of dietary variety &
      dietary fat on energy intake will be similar.

      We anticipate that the results of this investigation will lead to a greater understanding of
      the relative importance of eating patterns versus macronutrient composition in the etiology
      of obesity, and more specifically, dietary variety versus dietary fat in determining energy
      intake. More importantly, it will help lay a foundation for improved dietary recommendations
      concerning weight loss and prevention of excess weight gain in adulthood.
    

Detailed description: 
      The relative importance of dietary patterns vs. macronutrient composition in affecting energy
      intake and body weight remains uncertain. In this study we propose to investigate the
      relative effects of dietary variety vs dietary fat on voluntary energy intake in adults. We
      will quantify and compare the effects of typical ranges of variety & fat intakes in the
      American diet on voluntary energy intake. The primary hypotheses to be tested are 1)an
      increasing availability of entree/side/snack/dessert variety offered will significantly
      increase voluntary energy intake in a dose-response fashion when other dietary factors known
      to influence energy intake are held constant. 2)The separate effects of dietary variety &
      dietary fat on energy intake will be similar.

      We anticipate that the results of this investigation will lead to a greater understanding of
      the relative importance of eating patterns versus macronutrient composition in the etiology
      of obesity, and more specifically, dietary variety versus dietary fat in determining energy
      intake. More importantly, it will help lay a foundation for improved dietary recommendations
      concerning weight loss and prevention of excess weight gain in adulthood
    

Intervention name(s): Controlled Feeding Intervention
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single
Primary purpose: Prevention
Cryo-Touch II for the Treatment of Wrinkles
Condition: Facial Wrinkles
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      This is a prospective, non-randomized study to evaluate the performance of the MyoScience
      Cryo-Touch II device for the treatment of wrinkles.
    


Intervention name(s): Cryo-Touch II
Intervention type(s): Device
Intervention description(s): Percutaneous treatment with the device
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Role of Dendritic Cells in Hepatitis C Infection
Condition: Chronic Hepatitis C Infection
MeSH terms: Infections; Hepatitis A; Hepatitis C; Hepatitis C, Chronic; Hepatitis
Study type: Interventional

Summary: 
      The role of the dendritic cells, the most potent antigen presenting cells, in the
      establishment of chronic hepatitis C is not established. The study aims to define whether the
      dendritic cells are affected by the hepatitis C virus and whether that bears an impact on the
      antiviral immune response they generate. The hypothesis is explored by investigating a group
      of patients prior to and after the initiation of standard treatment for hepatitis C with
      pegylated Interferon and Ribavirin.
    


Intervention name(s): Viraferon-peg and Rebetol
Intervention type(s): Drug
Intervention MeSH terms: Ribavirin
Primary purpose: Basic Science