bioihbjkbjnl/mcl2 huggingface dataset:
Effect of Food Form on Satiety and Gastric Emptying
Condition: Appetite
Study type: Observational

Summary: 
      Our objective is to determine whether food form (liquid vs. solid) alters gastric emptying,
      satiety, and food intake, when all macronutrients and fiber are controlled. The study
      population will include 10 healthy women, who have a normal body mass index. We have chosen
      to evaluate only women because this is a small pilot study and one of our endpoints is
      gastric emptying. Gastric emptying is known to differ between men and women. Gastric emptying
      will be evaluated using the Smartpill technology, satiety will be evaluated using
      computerized visual analog scales/questions, and food intake will be measured by providing
      subjects with an ad libitum/buffet-style lunch.

      Our hypothesis is that our subjects will be less hungry after they eat a solid breakfast
      compared to a liquid breakfast. We also hypothesize that our subjects will have a slower
      gastric emptying time after they eat the solid meal. Lastly, we think subjects will want to
      eat less food at lunch time if they have eaten a solid meal compared to a liquid meal for
      breakfast.
    


Intervention name(s): Liquid Breakfast; Solid Breakfast Meal
Intervention type(s): Other; Other
Intervention description(s): The liquid breakfast meal will contain 370 calories and will consist of fruit juices and skim milk; The solid breakfast will contain 370 calories and will consist of oatmeal, golden delicious apples, blueberries, skim milk, and brown sugar.
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Healthy women; age 18 - 35; body mass index in the healthy range between 18.5 and 25;
        proficient English speakers; non-smoking; not taking medications; non-dieting (weight
        stable over last 3 months); able to swallow a large capsule
      
Keywords: Appetite; Satiety; Gastric Emptying Time; Food Intake; Food Form
Triathlon® Posteriorly Stabilized (PS) Total Knee System - Outcomes Study
Condition: Arthroplasty, Replacement, Knee
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the clinical outcomes (range of motion, pain,
      function, radiographic stability, and health related quality of life) of patients receiving
      the Triathlon® Posterior Stabilized (PS) Total Knee System. These outcomes will be evaluated
      using pre-operative scores and comparing them to post-operative scores in addition to being
      compared with cases who received the Scorpio® PS implant.
    

Detailed description: 
      The Triathlon® Posteriorly Stabilized (PS) Total Knee System components are for use in
      cemented total knee arthroplasty for painful, disabling joint disease of the knee resulting
      from non-inflammatory degenerative joint disease (including osteoarthritis, traumatic
      arthritis or avascular necrosis) or rheumatoid arthritis (excluded from this study according
      to protocol).

      The components are designed to improve range of motion (ROM) and stability. This study serves
      to demonstrate that subjects have reduced pain, increased ROM and improved stability
      following implantation with the Triathlon® PS Total Knee System.
    

Intervention name(s): Triathlon® PS Total Knee System
Intervention type(s): Device
Intervention description(s): Triathlon® PS Total Knee system
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Knee
Postural Control in Covid-19
Condition: COVID-19; Performance
MeSH terms: COVID-19
Study type: Observational [Patient Registry]

Summary: 
      This study was planned to investigate how much the anaerobic performance of individuals who
      experienced fatigue with Want (Wingate) affected their postural sway parameters.
    

Detailed description: 
      The postural sway parameters of the individuals will be evaluated using the "Kistler Force
      Plate" and the anaerobic values will be evaluated using the Wingate Anaerobic Strength Test
      and the "Excalibur Sport Ergometer" device. The data obtained will be compared with the data
      of patients with and without Covid-19 disease using appropriate statistical methods.
    

Intervention name(s): Neuromuscular fatigue and postural sway evaluation
Intervention type(s): Diagnostic Test
Intervention description(s): Neuromuscular fatigue will be established by using the Excalibur Sport Ergometer device and the Wingate Anaerobic Strength Test. Postural sway will be evaluated with Cyst Force Plate Balance device. This device is a precision device that provides objective measurable data.
Other intervention name(s): Postural sway; Postural sway evaluation
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with covid-19 and Have not had covid 19 before
Evaluation of Serum Ages Levels in Patients With Endometriosis
Condition: Endometriosis
MeSH terms: Endometriosis
Study type: Observational

Summary: 
      Serum AGES (Advanced Glycation End Products) levels of endometriosis patients are compared
      with a group of healthy volunteers of the same age.
    

Detailed description: 
      Serum AGES (Advanced Glycation End Products) levels are compared with 45 endometriosis
      patients and 45 healthy volunteers of the same age. The energy metabolism of the
      endometriosis group and its possible relationship with the endometriosis stage will be
      compared since AGES (Advanced Glycation End Products) gives information about the energy
      metabolism of the people.
    

Intervention name(s): Advanced Glycation End Products (AGEs)
Intervention type(s): Other
Intervention description(s): Advanced Glycation End Products (AGEs) releated with energy metabolism, In this study, the possible relationship between the serum levels of Advanced Glycation End Products (AGEs) of endometriosis patients and the disease and its stage is evaluated.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Women aged 18-45 diagnosed with endometriosis (surgery or ultrasound)
      
Keywords: AGES (Advanced Glycation End Products)
Serotonin, Leptin and Adiponectin Level in Patients With Postpartum Depression: Controlled Study
Condition: Postpartum Depression
MeSH terms: Depression, Postpartum; Depression; Depressive Disorder
Study type: Observational

Summary: 
      After vaginal delivery, all of the participants will evaluate by using Edinburg depression
      scale and venous blood sample will obtain. Postpartum depression will consider the result of
      scale 13 and above according to Turkhish translate. Then leptin, adiponectin and serotonin
      level will compare between depressed and nondepressed women.
    


Intervention name(s): leptin, serotonin and adiponectin level; leptin,serotonin, adiponectin level
Intervention type(s): Other; Other
Intervention MeSH terms: Serotonin
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        According to Edinburg depression scale womenn who taken 13 point and above.
Evaluation of a Smartphone Based Screening Tool for Neonatal Jaundice in Surabaya, Indonesia
Condition: Jaundice, Neonatal
MeSH terms: Jaundice, Neonatal; Jaundice
Study type: Interventional

Summary: 
      A cross-sectional conductive study aiming to evaluate the accuracy of a novel smartphone
      application that estimates bilirubin levels in newborns in Surabaya.
    

Detailed description: 
      A cross-sectional conductive study aiming to evaluate the accuracy of a novel smartphone
      application that estimates bilirubin levels in newborns at Airlangga University hospital and
      RSIA Kendangsari MERR in Surabaya.

      This cross-sectional study evaluates the accuracy of a novel smartphone application that
      estimates bilirubin levels in Indonesian newborns. The Picterus Calibration Card was placed
      on the chest of the newborn with the hole in the card placed over the infant's sternum. A
      validated smartphone with Picterus JP was used to collect digital images.
    

Intervention name(s): Picterus Jaundice Pro
Intervention type(s): Device
Intervention description(s): In this study we aim to collect data of newborns with wider range of bilirubin levels to adjust the Picterus JP algorithm and optimize the app performance. This will enable a high qualitative estimation of bilirubin levels in the blood of new-borns for all skin colors.
Other intervention name(s): Picterus JP
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Screening
Study of X0002 Following Escalating Single and Multiple Doses Administered as Topical Application in Healthy Volunteers
Condition: Osteoarthritis
MeSH terms: Osteoarthritis
Study type: Interventional
Phase: Phase 1

Summary: 
      Primary Objectives:

      To evaluate the safety and tolerability of escalating single and multiple doses of X0002
      administered as a topical application.

      Secondary Objectives:

      To characterize the single and and multiple pharmacokinetics of escalating doses of X0002 and
      its active metabolite ibuprofen as a topical application.
    


Intervention name(s): X0002; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): External Spray; External Spray
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Osteoarthritis
Prehabilitation to Overcome the Stress of Surgery: the Role of Nutrition in Enhancing Postoperative Functional Capacity
Condition: Colorectal Cancer
MeSH terms: Colorectal Neoplasms
Study type: Interventional

Summary: 
      To determine the impact of nutritional supplementation with whey protein on postoperative
      functional capacity in patients undergoing colorectal surgery for cancer.It is hypothesized
      that, compared with a control group receiving nutrition counselling only, patients receiving
      nutritional counselling along with preoperative and postoperative nutritional supplements
      will have a significantly improved change in functional walking capacity from baseline to 8
      weeks after surgery.
    

Detailed description: 
      The aims of this research project are the following:

        1. Determine to what extent a nutritional prehabilitation regimen, which includes whey
           protein, initiated before surgery and continued after surgery, optimizes the recovery of
           functional walking capacity following colorectal resection for cancer.

        2. To understand further which measures of immediate surgical recovery are sensitive to
           prehabilitation interventions, and predict change in later outcome measures.
    

Intervention name(s): Whey Protein (Immunocal®)
Intervention type(s): Dietary Supplement
Intervention description(s): The amount of Immunocal® whey protein the patient is required to take daily will be determined on an individual basis by the nutritionist according to the assessed protein deficit in the patient's diet.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Cancer; Colon; Rectum; Surgery
Effects of Food Advanced Glycation Endproducts on Vascular Function in Diabetes
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      Recent evidence supports detrimental effects of advanced glycation endproducts (AGE) on
      vascular function (VF). Though, the effect of AGE-modified proteins alone on vascular
      function remained unknown. Therefore, the aim of our study is to investigate the effects of
      heat-treated, glycated beta-lactoglobulins (BLG) on vascular function in subjects with type 2
      diabetes mellitus (T2DM) and to compare it to non-glycated, heat-treated BLG.
    

Detailed description: 
      In a double-blind, controlled, randomized, cross-over manner, 19 subjects with T2DM will
      receive on 2 different days beverages containing either glycated, heat-treated BLG or
      non-glycated, heat-treated BLG.

      Macrovascular (brachial ultrasound of flow mediated dilatation -FMD) and microvascular
      function (laser-doppler measurements of reactive hyperemia at the hand) at baseline (T0), as
      well as 90 (T90) and 180 (T180) minutes after each beverage will be measured.
    

Intervention name(s): Glycated beta-lactoglobulins.; Non-glycated beta-lactoglobulins
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): oral, 20 g, single administration; 20 g, oral, single administration,
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Keywords: Diabetes; Advanced glycation endproducts; Endothelium
Web-based Interventions on Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Children
Condition: NAFLD; Web; Childhood Obesity
MeSH terms: Liver Diseases; Fatty Liver; Non-alcoholic Fatty Liver Disease; Pediatric Obesity
Study type: Interventional

Summary: 
      The web-based continuity of care intervention model to provide comprehensive nursing
      interventions for obese children with NAFLD, always tracking their performance status,
      enabling them to grasp the knowledge of healthy weight loss, develop good lifestyle habits,
      and reduce their weight, thus reducing the incidence of NAFLD in children.
    

Detailed description: 
      The web-based continuity of care intervention model to provide comprehensive nursing
      interventions for obese children with NAFLD, always tracking their performance status,
      enabling them to grasp the knowledge of healthy weight loss, develop good lifestyle habits,
      and reduce their weight, thus reducing the incidence of NAFLD in children.The primary outcome
      are serum biomarkers such as alanine aminotransferase (ALT) and gamma-glutamyl transferase
      (GGT) . Second outcomes are: aspartate aminotransferase, and liver imaging (liver ultrasound
      and magnetic resonance imaging), BMI, waist-to-hip ratio and quality of life. In addition,
      socio-demographic characteristics such as age, gender and ethnicity will be recorded. All
      outcomes were measured at baseline, week 4, week 16, week 24, week 36, and week 48 to
      determine the trajectory of change in outcome variables over intervention process.
    

Intervention name(s): web-based intervention
Intervention type(s): Other
Intervention description(s): Establishing management teams.
Establishment of a nursing intervention team.
Daily uploading of health intervention records
Regularly delivering related health knowledge.
Home visiting
Psychological guidance. The health teachers in the team should closely understand the psychological trends of the patients during the telephone follow-up and home visits and verbally communicate more with the children to stimulate them to develop good living habits and increase their confidence in healing.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: web-based intervention
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: NAFLD; obese children; web; education; protocol
A Study to Evaluate the Safety, Pharmacokinetics and Oral Bio Availability of Veliparib in Subjects With Solid Tumors
Condition: Oncology; BRCA Mutated; High Grade Serous Ovarian Cancer; BRCA Mutated Breast Cancer
MeSH terms: Ovarian Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a 3 part phase 1 study to evaluate the safety, pharmacokinetic and oral
      bioavailability of veliparib in subjects with solid tumors.
    


Intervention name(s): Veliparib
Intervention type(s): Drug
Intervention description(s): veliparib
Intervention MeSH terms: Veliparib
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: High grade serous ovarian cancer; BRCA mutated breast cancer; BRCA mutated; Oncology
Evaluating the Safety, Tolerability, Pharmacokinetics and Receptor Occupancy of BMS-984923
Condition: Alzheimer Disease
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      This project seeks to develop a novel disease-modifying compound for Alzheimer's disease
      (AD).
    

Detailed description: 
      The primary objective of this study is to evaluate the safety, tolerability, and
      pharmacokinetics of BMS-984923 in healthy participants. A secondary objective of this study
      is to conduct a receptor occupancy sub-study aimed at determining drug receptor occupancy at
      each dose using [18F]FPEB Positron Emission Tomography.
    

Intervention name(s): BMS-984923
Intervention type(s): Drug
Intervention description(s): Day 1: Admission, administration of study drug, and 2 night in-patient stay; Day 3: Discharge following the completion of all scheduled procedures.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: The study will enroll four cohorts of 6 participants each. Study drug will be administered in sequentially increasing dose groups. For all 6 participants at a dose cohort, a safety assessment review will be completed prior to advancing the next higher dose level.
Masking: None (Open Label)
Primary purpose: Basic Science
Effects of FTY720 on Heart and Lung Functions in Healthy Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is designed to assess the effects of two doses of FTY720 on lung (pulmonary) and
      cardiac (heart) functions in healthy volunteers.
    


Intervention name(s): FTY720
Intervention type(s): Drug
Intervention MeSH terms: Fingolimod Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: pharmacodynamic effects, cardiac effects, healthy subjects, synthetic sphingosine 1 phosphate (S1P) receptor modulator; Healthy male and female subjects
Internet-based HIV/STI Prevention for Young MSM Receiving HIV Testing
Condition: HIV; HIV Infections
MeSH terms: HIV Infections
Study type: Interventional

Summary: 
      The purpose of this study is to develop an empirically validated, scientifically-based HIV
      and STI prevention program that can be delivered online to young men who have sex with men
      (YMSM) who were recently tested for HIV.
    

Detailed description: 
      Presently, there are a limited number of proven HIV interventions culturally tailored to
      young men who have sex with men (YMSM). This is alarming because Men who have sex with men
      comprise 68% of HIV/AIDS diagnoses in men, despite representing a much smaller proportion of
      the population. In addition, MSM are reporting more sexual risk behavior than in previous
      years and there is significant concern that HIV infection rates may once again be on the rise
      after more than a decade of remaining relatively stable.

      The Internet is a viable intervention avenue because of it's high percentage of accessibility
      and usage, especially among young adults. Moreover, it might hold a strong appeal for YMSM,
      since its anonymity confers a sense of perceived safety against stigma surrounding HIV
      prevention information.

      The purpose of this study is to compare two different versions of an online HIV/STI
      intervention for YMSM. This study is part of an overall program of research designed to
      understand and prevent HIV infection among high-risk youth. Participation in this study will
      help us to determine the usefulness of an tailored and interactive HIV Internet-assisted
      intervention.
    

Intervention name(s): Keep It Up!; Information only
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Online HIV Intervention Prevention Website tailored to Young Men that Have Sex with Men. Website is tailored to be more engaging, includes videos and games.; Medically fact based HIV information delivered online.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Keywords: HIV Risk; Internet Intervention; Homosexuality, Male; HIV Seronegativity
Robotic Assessment of Lower Extremity Motor Learning
Condition: Healthy Subjects
Study type: Interventional

Summary: 
      The aim of the study is to assess the ability of healthy subjects to generate a motor
      adaptation in response to a mechanical perturbation generated by a robotic system for
      treadmill-based gait training (Lokomat by Hocoma AG, a device that received 510K FDA
      clearance).
    

Detailed description: 
      The study is divided into two phases.

      In phase I of the study, we intend to assess the response of individuals to a variety of
      different mechanical perturbations generated by a robotic system for treadmill-based gait
      training (Lokomat by Hocoma AG). Such response is quantified as a displacement from the
      baseline (i.e. gait cycles with no mechanical perturbation) trajectory of motion of the foot
      during the swing phase of the gait cycle. This portion of the study is expected to allow us
      to identify mechanical perturbations that are suitable to study motor adaptation.

      In phase II of the study, we plan to carry out experiments using the above-mentioned robotic
      system to assess the magnitude of the motor adaptation to the mechanical perturbations
      identified in phase I as suitable for the study. The magnitude of the motor adaptation is
      quantified as the percentage of the deviation from the baseline trajectory of motion of the
      foot that subjects compensate for when exposed to the perturbation during multiple
      consecutive gait cycles.

      It is worth noticing that the robotic system utilized to generate the mechanical
      perturbations (i.e. Lokomat by Hocoma AG) is not programmed by the company to generate the
      mechanical perturbations evaluated in this project. Our research group wrote the programs to
      generate such perturbations. It is also worth emphasizing that the 510K FDA clearance does
      not cover the modifications implemented by our research group.
    

Intervention name(s): Robot-induced perturbations
Intervention type(s): Device
Intervention description(s): A robotic system is used to generate mechanical perturbations and study how subjects generate motor adaptations in response to the mechanical perturbations.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: motor adaptation; lower extremity motor learning