bioihbjkbjnl/mcl2 huggingface dataset:
the Effect of High Dose Ascorbic Acid on Critically Ill Patients With ARDS
Condition: Acute Respiratory Distress
Study type: Interventional

Summary: 
      1. To access role of vitamin C supplementation in ARDS patients on the following:

           Oxidants/ antioxidants imbalance Length of hospital stay Mortality rate Weaning from
           mechanical ventilator Incidence of adverse drug reaction

        2. To access tolerability of vitamin C supplementation in patients with ARDS.
    

Detailed description: 
      Acute Respiratory distress syndrome (ARDS) is a form of severe hypoxemic respiratory failure
      due to severe impairment of gas exchange and lung mechanics that is characterized by
      inflammatory injury to the alveolar capillary barrier, with extravasation of protein-rich
      edema fluid into the air space. Current ARDS antioxidant treatment strategy, is based upon
      supportive therapies including low tidal volume ventilation, fluid management, nutritional
      support and glucocorticoids.

      Ascorbic acid or Vitamin C is an important dietary water-soluble antioxidant, it
      significantly decreases the adverse effects of ROS such as reactive oxygen and nitrogen
      species that can cause oxidative damage to macromolecules. Recent studies show that high dose
      of Vitamin C have protective effects against overwhelming oxidative stress due to critical
      illness. Vitamin C improves immune function and improves tissue perfusion and reduce tissue
      hypoxia and subsequent organ dysfunction. Also, Ascorbate, the redox form of vitamin C is
      physiological antioxidant and has bacteriostatic activity Hence the study aims to evaluate
      the impact of IV Vitamin C in ARDS, as a novel pharmaceutical approach in an attempt to
      improve the clinical outcome of ARDS patients, decrease other medications toxicities and
      improve patients' quality of life.

      The objective of the current study was to evaluate the efficacy, safety and tolerability of
      IV Vitamin C administration in addition to conventional therapy in patients with ARDS by
      assessing the following:

        1. Oxidants/ antioxidants imbalance

        2. Length of hospital stay

        3. Mortality rate

        4. Weaning from mechanical ventilator

        5. Incidence of adverse drug reaction

        6. Serum IL8 levels

      8. Serum Vitamin C levels
    

Intervention name(s): vitamin c
Intervention type(s): Dietary Supplement
Intervention description(s): vitamin c IV 10 G
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
An Open-label Study Investigating the Disposition and QT/QTc Interval Effects of 400 mg [14C]-Iniparib(3.7 MBq, 100 µCi)
Condition: Advanced Solid Tumors
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a Phase 1, multi-center, open-label study.

      During Segment 1, patients are administered a single IV administration of [14C]-iniparib.

      During Segment 2, patients are administered iniparib with or without additional chemotherapy.
      Acceptable chemotherapy regimens is limited to those for which previous experience with
      iniparib exists.
    


Intervention name(s): Iniparib
Intervention type(s): Drug
Intervention description(s): Solution for infusion
60-minute intravenous infusion
Other intervention name(s): SAR240550; BSI-201
Intervention MeSH terms: Iniparib
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
TIVA, Inhalation Anesthesia, and Surgical Site Infection
Condition: Colorectal Disorders
Study type: Observational

Summary: 
      The purpose of this retrospective study was to evaluate the incidence of SSI after colorectal
      surgery under the general anesthesia by different general anesthetic technique: inhalation
      versus total intravenous anesthesia.
    


Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Adult patients who underwent elective colorectal surgery under general anesthesia from
        January 2011 to December 2013 at SNUBH.
Study to Assess the Safety and Efficacy of Modified-Release Prednisone (Lodotra®) Therapy in Patients With Active Rheumatoid Arthritis
Condition: Rheumatoid Arthritis
MeSH terms: Arthritis; Arthritis, Rheumatoid
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of the study is to compare the safety and efficacy, with regards to the signs and
      symptoms, of MR prednisone (Lodotra®) versus placebo in combination with standard Disease
      Modifying Anti-Rheumatic Drug (DMARD) treatment in patients with active rheumatoid arthritis.
    


Intervention name(s): MR prednisone; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 1 x 5 mg daily; 1x daily
Intervention MeSH terms: Prednisone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Signs and Symptoms; Autoimmune Diseases; Joint Diseases; Arthritis; Connective Tissue Diseases; Arthritis, Rheumatoid; Rheumatic Diseases; Predniso(lo)ne
Encapsulated Flavour Effects on Satiety
Condition: Overweight
MeSH terms: Overweight
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the satiating effects of different gummies with
      encapsulated flavour on overweight subjects (BMI ≥25 and <30 kg / m2). Some studies have
      shown that the contribution of different flavours could reduce food intake. This have made
      grown the interest of food industry in incorporate these compounds in food and to being able
      to develop new functional foods into the control of body weight, as well as variables of
      glucose metabolism and lipid profile, which can contribute to te prevention of cardiovascular
      diseases.
    

Detailed description: 
      A randomized, cross-over and double-blind pilot study with 3 study arms is being performed to
      evaluate the satiating properties of the encapsulated flavours in different gummies in a
      group of healthy overweight subjects.

      The investigators included 12 participants (6 men and 6 women) between 18 and 55 years (BMI
      ≥25 and <30 kg / m2). All volunteers will be randomized into 3 study groups, and participants
      will receive the 3 different study products in order during the 3 experimental phases.
    

Intervention name(s): Control gummy with free flavour (without encapsulating); Experimental gummy with 50% free/50% encapsulated flavour; Experimental gummy with 100% encapsulated flavour
Intervention type(s): Other; Other; Other
Intervention description(s): 12 g/day (3 gummies); 12 g/day (3 gummies); 12 g/day (3 gummies)
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Other
Keywords: Satiety; Encapsulated flavour; Gummies; Visual Analogue Scale; Cross-over
Polyaxial Brace Fixing for the Treatment of Congenital Clubfoot
Condition: Clubfoot
MeSH terms: Clubfoot; Talipes; Equinus Deformity; Foot Deformities
Study type: Interventional

Summary: 
      Congenital idiopathic clubfoot (CC) is the fifth most common congenital malformation in
      children. The Ponseti method is an effective protocol for treatment of congenital idiopathic
      clubfoot. Plaster is essential for the Ponseti treatment. This paper describes a new brace
      that can be used for the treatment of clubfoot in newborns and infants instead of plaster.
    

Detailed description: 
      Methods In the orthopedic department of our hospital, 38 infants and newborns, (57 feet) ,all
      the patients were under the age of 3 months with congenital clubfoot underwent polyaxial
      braces between Jan, 2011 to Oct ,2013. Polyaxial brace was used for the deformity correction.
      Then, during the following 1-3 years, the Dennis braces were used during the night in case of
      recurrence. Prospective follow-up for a mean duration of 25 months (range, 15-36months) was
      carried out. The efficacy of the treatment was assessed by Pirani's scoring system before and
      after treatment.
    

Intervention name(s): Polyaxial brace
Intervention type(s): Device
Intervention description(s): The Polyaxial brace were made by a technician trained by the China National Disabled Persons Federation. For all patients, gypsum models were prepared first, and then braces were fabricated according to the models. The detailed technique was fully in accordance with the Ponseti method.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Congenital idiopathic clubfoot; Pirani score; infant; polyaxial brace
Validity of Different Prognostic Models Assessing 1 Year Survival After Liver Transplantation
Condition: Liver Transplantation
Study type: Observational

Summary: 
      Validity of MELD vs MELD XI in assessing 1 year survival after living donor liver
      transplantation.
    


Intervention name(s): retrospecive observational
Intervention type(s): Other
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        liver failure
Effect of Propofol Midazolam on Cerebral Oxygenation and Metabolism During Clipping of Ruptured Cerebral Aneurysm
Condition: Ruptured Cerebral Aneurysm
MeSH terms: Intracranial Aneurysm; Aneurysm
Study type: Interventional

Summary: 
      Despite the theoretical benefits of i.v. agents, volatile agents remain popular. In a study
      comparing desflurane, isoflurane, and sevoflurane in a porcine model of intracranial
      hypertension, at equipotent doses and normocapnia, cerebral blood flow (CBF) and ICP were
      least with sevoflurane.

      Propofol is the most commonly used intravenous anesthetic. It has many theoretical advantages
      by reducing cerebral blood volume (CBV) and ICP and preserving both autoregulation and
      vascular reactivity. Neurosurgical patients anaesthetized with propofol were found to have
      lower ICP and higher CPP than those anaesthetized with isoflurane or sevoflurane.

      The well known pharmacodynamic advantages of intravenous anesthetics may give this group of
      drugs superior cerebral effects when compared with inhalation anesthetics.
    

Detailed description: 
      The aim of this study is to evaluate the cerebral hemodynamics and global cerebral
      oxygenation as well as the systemic hemodynamic changes using midazolam and propofol as total
      intravenous anesthetics (TIVA) in comparison with sevoflurane anesthesia in clipping of
      ruptured cerebral aneurysm.
    

Intervention name(s): Total intravenous anesthesia (TIVA); Inhalation Anesthesia; Rescue fentanyl
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Propofol (1.5-2 mg/kg/h) infusion, Midazolam (0.12 mg/kg/h) infusion; Sevoflurane at a concentration of 2-2.5%; Fentanyl in repeated doses (50 µg) when needed (heart rate or mean arterial blood pressure increase more than 20% of the basal value) are used for maintenance of analgesia
Intervention MeSH terms: Fentanyl; Anesthetics
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Phase 2 Study of KHK4577
Condition: Atopic Dermatitis
MeSH terms: Dermatitis, Atopic; Dermatitis; Eczema
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is an randomized double-blind placebo-controlled study to evaluate the efficacy
      and the safety of oral KHK4577 for 6 weeks in patients with atopic dermatitis.
      Pharmacokinetics of KHK4577 will also be assessed.
    


Intervention name(s): KHK4577; Placebo
Intervention type(s): Drug; Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Effects of Acute Pain on Cognitive Performance in Young Adults
Condition: Pain, Acute; Cognition
MeSH terms: Acute Pain
Study type: Interventional

Summary: 
      The effects of pain on cognitive performance have not been thoroughly investigated. Broadly,
      the purpose of this research is to investigate the effects of acute pain on performance of a
      variety of cognitive performance measures. The investigators hypothesize that acute pain
      impairs cognitive performance, particularly cognitive measures of working memory, attention,
      and processing speed.
    


Intervention name(s): pain delivery with capsaicin and heat; distractor delivery with sensory TENS
Intervention type(s): Procedure; Procedure
Intervention description(s): Experimental pain paradigm delivered (capsaicin cream combined with heat) that is short-term and painful but not harmful; Distractor stimulus delivered (sensory TENS electrical stimulation) that is short-term and attention-demanding but not painful
Intervention MeSH terms: Capsaicin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: acute pain; cognition; pain; cognitive ability; young adults
A Clinical Trial to Evaluate the Efficacy of Two Acne Treatments
Condition: Acne
MeSH terms: Acne Vulgaris
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to evaluate the efficacy of 2 acne treatments for 24 weeks of
      use in adult men and women with mild to moderate facial acne, at least 5 inflammatory
      lesions, and at least 10 - 100 non-inflammatory lesions.
    

Detailed description: 
      1. To characterize the effectiveness of the acne treatment in lesion count at week 1, week
           2, week 6, week 12, and week 24 as compared to baseline and compare between treatments

        2. To characterize the effectiveness of the acne treatment in Investigator's Global
           Improvement Assessment at week 1, week 2, week 6, week 12, and week 24 as compared to
           baseline and compare between treatments

        3. To characterize the effect of the acne treatment in clinical grading of efficacy
           parameters through digital images at week 6, week 12, and week 24 as compared to
           baseline and compare between treatments

        4. To characterize the effect of the acne treatment in subject self-assessment
           questionnaire responses at week 1, week 2, week 6, week 12, and week 24 as compared to
           baseline and compare between treatments
    

Intervention name(s): Product A; Product B
Intervention type(s): Drug; Drug
Intervention description(s): Product A applied topically to the entire face or other affected area of the skin once daily; Product B applied topically to affected area of the skin 1 to 3 times daily
Other intervention name(s): Adapalene; Salicylic acid
Intervention MeSH terms: Salicylic Acid; Adapalene; Salicylates
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
International Ataxia Rating Scale in Younger Patients
Condition: Ataxia Telangiectasia
MeSH terms: Ataxia; Cerebellar Ataxia; Ataxia Telangiectasia; Telangiectasis
Study type: Observational

Summary: 
      The project will collect information on the mapping of clinical ratings on a number of scales
      that are used in the assessment of patients with ataxias.
    


Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Known patients with ataxia/ataxia telangiectasia
Effect of Manipulation on Coccydynia
Condition: Coccyx Disorder; Pelvic Floor; Weak; Stretch
Study type: Interventional

Summary: 
      The aim of this study was to investigate the efficacy of manipulation combined with exercise
      as a treatment for patients with coccydynia.
    

Detailed description: 
      Subject: Coccydynia is a painful condition characterized by inflammation and discomfort in
      the coccyx region, commonly known as the tailbone. It can significantly affect an
      individual's quality of life by impairing their ability to sit, stand, or engage in daily
      activities. Various treatment approaches have been explored to alleviate the symptoms of
      coccydynia, including manipulation techniques and exercise interventions. However, to date,
      there is a scarcity of research investigating the combined effects of manipulation and
      exercise for patients with coccydynia.

      Purpose: The purpose of this study is to evaluate the efficacy of combining manipulation
      techniques with exercise interventions for patients diagnosed with coccydynia, a painful
      condition affecting the coccyx region. Despite the debilitating impact of coccydynia on daily
      activities and quality of life, there is a limited understanding of the optimal treatment
      approach for this condition. This study aims to address this knowledge gap by investigating
      the potential benefits of combining manipulation and exercise in managing coccydynia.
    

Intervention name(s): Exercises; Coccyx Manipulation
Intervention type(s): Other; Other
Intervention description(s): Stretching exercise for the piriformis and iliopsoas muscles. strengthening exercises for pelvic floor muscles; Application of manipulation to relax the levetor ani muscle
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Strengthening Maternal Neonatal and Child Health Services in a Rural District of Pakistan
Condition: Antepartum Hemorrhage; Postpartum Hemorrhage; Anemia; Eclampsia; Neonatal Sepsis; Birth Asphyxia; Diarrhoea; Pneumonia
MeSH terms: Neonatal Sepsis; Postpartum Hemorrhage; Eclampsia; Asphyxia Neonatorum; Hemorrhage; Diarrhea; Asphyxia
Study type: Interventional

Summary: 
      The Maternal Neonatal and Child health indicators in District Dadu of Pakistan portrays a
      dismal pictures and after the floods of 2010-2011 the health infrastructure of this district
      was badly affected. Aga Khan University Pakistan is intending to implement a service delivery
      project for the improvement of Maternal Neonatal and Child health situation through evidence
      based MNCH interventions.
    

Detailed description: 
      The Aga Khan University is implementing together with its local partners a MNCH project in
      five Union Councils (UC) in Dadu District in Sindh Province. The project will scale up the
      already existing health services for MNCH in the district referral hospital and the five
      Basic Health Units (BHUs), one in each UC. Institutional based services as well as their
      scope for outreach to pregnant women, mothers and children in the communities with the aim to
      promote safe deliveries as per WHO guidelines and Government policy will be enhanced. In
      order to deliver quality services, the facilities will be renovated and equipped and the
      capacity of the existing staff will be strengthened through different training courses in
      MNCH. In addition professionally trained Lady Health Visitors will be introduced in the BHUs,
      who will conduct all maternal services including deliveries in the BHU and the communities.
      The health staff is furthermore responsible to establish and facilitate community support
      groups and raise communal awareness for the importance of mother and child health care as
      well as safe deliveries with skilled attendants. Operational research is an integral part of
      this pilot project. The research validates the progress and improvement of maternal and child
      health indicators. The results will be used to lobby the scale up of MNCH interventions with
      the Ministry of Health in Pakistan.
    

Intervention name(s): Maternal Neonatal and Child Health Interventions
Intervention type(s): Other
Intervention description(s): Antenatal care, postnatal care, skilled birth attendance, recognition and referral of complicated cases, immunization
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Effectiveness Study of Physical Therapy as an Adjunct to a Lumbar Therapeutic Selective Nerve Root Block
Condition: Sciatic Neuropathy; Radiculopathy; Intervertebral Disk Displacement
MeSH terms: Intervertebral Disc Displacement; Radiculopathy; Sciatic Neuropathy
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine if participation in physical therapy in conjunction
      with a selective nerve root block in the lumbar spine is more effective than just receiving
      the injection alone for patients with low back and leg pain from a disk herniation
      (sciatica).
    

Detailed description: 
      Recent reviews report moderate to strong evidence for short-term relief but limited evidence
      for long-term improvement. Anecdotal reports and case studies suggest good outcomes with
      various physical therapy interventions however well-designed research studies examining
      treatments in combination are lacking. The management of lumbar radicular pain often includes
      the combination of physical therapy and therapeutic selective nerve root blocks with the
      rationale that reducing inflammation and pain will permit greater participation in physical
      therapy. The effectiveness of this combination of treatment has not been studied and is the
      purpose of this pilot study.
    

Intervention name(s): Lumbar injection; Rehabilitation following lumbar injection
Intervention type(s): Other; Other
Intervention description(s): Patients are instructed to resume normal activity as tolerated.; Participants are referred to an average of four weeks of physical therapy after receiving a lumbar injection. Physical therapy designed to include end-range directional preference exercises and/or mechanical traction to reduce lower extremity symptoms and progress activity tolerance.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: sciatic neuropathy; physical therapy; spinal injections
Comparison Trial of Letrozole to Anastrozole in the Adjuvant Treatment of Postmenopausal Women With Hormone Receptor and Node Positive Breast Cancer
Condition: Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Interventional
Phase: Phase 3

Summary: 
      Eligible patients will be post-menopausal hormone receptor- and lymph node-positive females
      who recently underwent primary surgery for breast cancer. Patients will be randomized to
      letrozole (2.5 mg per day for 5 years) vs anastrozole (1 mg per day for 5 years). Follow up
      will occur for 5 years after the completion of enrollment for survival and disease status
      updates.
    


Intervention name(s): Letrozole; Anastrozole
Intervention type(s): Drug; Drug
Intervention description(s): 2.5 mg tablets; 1 mg tablets
Intervention MeSH terms: Letrozole; Anastrozole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Breast cancer; letrozole; anastrozole; adjuvant; postmenopausal; FACE