The Preventive Effects of Neurodynamic Mobilisation
Condition: Delayed Onset Muscle Soreness
MeSH terms: Myalgia
Study type: Interventional

Summary: 
      The aim of this study was to investigate the effects of neurodynamic mobilization (NM)
      technique on muscle damage and inflammation biomarkers, and pain, pressure pain threshold,
      range of motion (ROM), muscle strength, and functional status in delayed onset muscle
      soreness (DOMS). In the study, 32 healthy sedentary male volunteers were randomly divided
      into two groups as NM (n = 16) and placebo-NM (n = 16). After the initial evaluation of the
      individuals, femoral nerve NM and placebo NM techniques were administered three sets a day
      with ten repetitions for three days a week for three weeks. Three days after the end of the
      applications, the second evaluations were made and the DOMS creation protocol for the
      quadriceps femoris (QF) muscle was initiated. In order to trigger DOMS in individuals, 30
      sets and 10 repetitions of eccentric knee extension (35°-95° flexion angles, 30°/sec speed)
      were performed on the dominant lower extremity with an isokinetic dynamometer. Baseline
      evaluations were repeated immediately after the DOMS protocol, and at hours 24, 48, and 72.
      During evaluations, muscle damage (serum creatine kinase (CK), lactate dehydrogenase (LDH),
      myoglobin, aspartate aminotransferase (AST), and alanine aminotransferase) and inflammation
      (interleukin-6 (IL-6), interleukin-10, interleukin-1 beta, tumor necrosis factor-alpha, and C
      reactive protein) biomarkers, pain (activity), pressure pain threshold, ROM, muscle strength
      (QF, hamstring eccentric/concentric) and performance (one-leg jump, vertical jump) parameters
      were measured.
    

Detailed description: 
      The aim of this study was to investigate the effects of neurodynamic mobilization (NM)
      technique on muscle damage and inflammation biomarkers, and pain, pressure pain threshold,
      range of motion (ROM), muscle strength, and functional status in delayed onset muscle
      soreness (DOMS). In the study, 32 healthy sedentary male volunteers were randomly divided
      into two groups as NM (n = 16) and placebo-NM (n = 16). After the initial evaluation of the
      individuals, femoral nerve NM and placebo NM techniques were administered three sets a day
      with ten repetitions for three days a week for three weeks. Three days after the end of the
      applications, the second evaluations were made and the DOMS creation protocol for the
      quadriceps femoris (QF) muscle was initiated. In order to trigger DOMS in individuals, 30
      sets and 10 repetitions of eccentric knee extension (35°-95° flexion angles, 30°/sec speed)
      were performed on the dominant lower extremity with an isokinetic dynamometer. Baseline
      evaluations were repeated immediately after the DOMS protocol, and at hours 24, 48, and 72.
      During evaluations, muscle damage (serum creatine kinase (CK), lactate dehydrogenase (LDH),
      myoglobin, aspartate aminotransferase (AST), and alanine aminotransferase) and inflammation
      (interleukin-6 (IL-6), interleukin-10, interleukin-1 beta, tumor necrosis factor-alpha,
      biomarkers, pain (activity), pressure pain threshold, ROM, muscle strength (QF, hamstring
      eccentric/concentric) and performance (one-leg jump, vertical jump) parameters were measured.
    

Intervention name(s): Femoral nerve neurodynamic mobilization; Femoral nerve placebo neurodynamic mobilization
Intervention type(s): Other; Other
Intervention description(s): The mobilization was carried out with the patient lying on the non-dominant side in a total flexion position, and the therapist performed the hip extension movement with the knee joint kept in flexion till the patient felt soreness or pain. This position was held for three seconds and then released. This tensioning maneuver was repeated in three sets of ten repetitions at each session and an interval of 2 min between series were performed. A total of nine sessions were performed within three weeks.; The individual was asked to lie on his non-dominant side and keep his head in the midline. In this position, while the pelvis was stabilized, the upper leg, which was in full knee extension, was grasped and the hip was abducted for 3 seconds. This maneuver was repeated in three sets of ten repetitions at each session and an interval of 2 min between series were performed. A total of nine sessions were performed within three weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The study was conducted as a randomized, double-blind, placebo-controlled parallel group trial.
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Keywords: Delayed onset muscle soreness; Neurodynamic mobilization; Muscle damage; Inflammation; Pain