bioihbjkbjnl/mcl2 huggingface dataset:
Bougie Assisted Endotracheal Intubation in Air-Q Intubating Laryngeal Mask And Fastrach Intubating Laryngeal Mask
Condition: Intubation;Difficult; Endotracheal Tube Wrongly Placed During Anesthetic Procedure
Study type: Interventional

Summary: 
      This study aims to compare using bougie as an assistant for endotracheal intubation through
      Air-Q and Fastrach intubating laryngeal mask devices when blind intubation fails as attempt
      to increase its success rate.
    

Detailed description: 
      The investigators hypothesis that using bougie with its smaller caliber or lesser size can
      facilitate intubation and improve success rate when blind intubation through both devices
      fails.

      Study objectives

        -  To make a comparison between Air-Q intubating laryngeal mask and Fastrach intubating
           laryngeal mask by using bougie assisted endotracheal intubation through both devices in
           patients undergoing elective surgeries in Suez Canal Hospitals.

        -  To assess the first trial success rate, the total success rate, time to tracheal
           intubation, the number of attempts, hemodynamics and adverse events.
    

Intervention name(s): Endotracheal tube introducers
Intervention type(s): Device
Intervention description(s): Endotracheal tube introducers (gum elastic bougie) for emergency intubation The endotracheal tube introducer (ETI) is an effective and inexpensive adjunct to difficult airway management that is easy to use.
ETI is solid introducer 60-70 cm long with a 35 - 40 distally angulated (Coude) tip. They are easy to use, widely available, and have been used as adjuncts to difficult direct laryngoscopy for many decades.
The gum elastic bougie is usually guided by tactile clicks as the device passes the cartilage rings of the trachea. After Supraglottic devices are removed, an ETT can subsequently be railroaded over the bougie.
Other intervention name(s): The Gum Elastic Bougie
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Bougie; Air Q; Fastrach
Resolution of Type 2 Diabetes Mellitus: Intensive vs. Conventional Glycaemic Control After Obesity Surgery
Condition: Type 2 Diabetes Mellitus; Obesity
MeSH terms: Diabetes Mellitus; Obesity; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      Obesity surgery is very effective in improving or even curing Type 2 Diabetes in patients
      with obesity. Many patients stop or reduce their medication after surgery and this can happen
      fairly quickly. The investigators do not know whether strict control of blood glucose/sugar
      after the operation makes any difference in the long term. Additionally many patients prefer
      their blood sugars to be a "bit high" because they are afraid of hypos.A number of studies
      have described patients whose eye, nerve and kidney disease has deteriorated when high sugars
      are controlled very quickly. The investigators want to ensure that surgery provides maximum
      benefit and remains safe in patients with diabetes. This study will help us decide if the
      investigators should be strict with blood glucose after obesity surgery operations or not and
      whether obesity surgery is safe for the eye, nerve and kidney complications of diabetes.
    

Detailed description: 
      Subjects would be randomised into intensive glycaemic control and conventional glycaemic
      control after obesity surgery. Data on complications of diabetes such as eye, nerve and
      kidney will be collected before obesity surgery and 1 year after surgery.
    

Intervention name(s): Insulin
Intervention type(s): Drug
Intervention description(s): All patients will be prescribed insulin glargine once a day. The dose of the insulin will be adjusted to achieve fasting capillary glucose levels between 5-7 in the intensive group and 7-9 mmol/l in the control group.
Other intervention name(s): Insulin Glargine
Intervention MeSH terms: Insulin; Insulin, Globin Zinc; Insulin Glargine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Type 2 Diabetes Mellitus; Obesity; Bariatric Surgery; Glycaemic control; Microvascular complications; Intensive; Conservative
Bemiparin as a Thromboprophylaxis After Gynaecological Surgeries
Condition: Deep Vein Thrombosis (DVT); Pulmonary Embolism
MeSH terms: Pulmonary Embolism; Thrombosis; Embolism; Venous Thrombosis
Study type: Interventional

Summary: 
      The use of prophylaxis for venous thromboembolism (VTE) remains grossly underused for women
      who undergo gynecologic surgery for benign conditions world wide and especially in developing
      countries including our region. Having a research in our locality for the first time might
      raise awareness of the importance of VTE prophylaxis.
    

Detailed description: 
      Deep vein thrombosis (DVT) and pulmonary embolism (PE), also referred to as venous
      thromboembolic events (VTE), are two major complications after gynaecological surgeries that
      can result in significant morbidity and mortality. The incidence of VTE after gynaecologic
      surgery varies depending on the method used for diagnosis. The rate of clinical DVT is
      estimated to be 3% after gynaecological surgery if no thromboprophylaxis was used. The rate
      of VTE assumed to decrease to 0.4% if Low molecular weight heparin was used as a
      thromboprophylaxis.

      According to our knowledge there are no published researches on the effect of the new second
      generation Low molecular Weight Heparin Bemiparin as a thromboprophylaxis after benign
      gynaecological surgery in comparison to a control group.
    

Intervention name(s): Bemiparin
Intervention type(s): Drug
Intervention description(s): Bemiparin Sodium 3,500IU anti Xa/0.3 ml solution for injection in pre-filled syringe will be provided for each patient in Bemiparin group (Moderate, High and Highest risk groups for thromboembolism) 6 hours after surgery and then daily for up to 7 days.
Other intervention name(s): Hibor; Laboratories Rovi pharmaceuticals
Intervention MeSH terms: Bemiparin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Thromboprophylaxis; Bemiparin; Low Molecular Weight Heparin; Major Gynaecological Surgeries; Benign Gynaecological Surgeries
Aromatase Inhibitors, Alone And In Combination With Growth Hormone In Adolescent Boys With Idiopathic Short Stature
Condition: Idiopathic Short Stature
MeSH terms: Dwarfism
Study type: Interventional
Phase: Phase 3

Summary: 
      When treating very short children in puberty we are time-limited, as sex hormones cause the
      growth plates to fuse and growth to end. Growth Hormone (GH), plus drugs that stop puberty,
      increase height potential, but leave children sexually infantile at a critical time in
      development. Human and animal data show that estrogen, in females and males, is a principal
      regulator of the fusion of the growth plate in puberty. Using aromatase inhibitors (AIs),
      which block testosterone to estrogen conversion, in boys with different growth disorders, we
      have shown that AIs may have beneficial effects enhancing height potential in growth-retarded
      males, without affecting their puberty. However, no direct comparison of the effect of AIs
      alone vs. conventional GH treatment has been done to date. This study will assess the effect
      of AIs alone, GH alone and combination treatment in enhancing height potential in adolescent
      boys with idiopathic short stature.
    


Intervention name(s): Aromatase Inhibitor; Growth Hormone; Aromatase Inhibitor and Growth Hormone
Intervention type(s): Drug; Drug; Drug
Other intervention name(s): Arimidex (Anastrozole); Femara (Letrozole); Nutropin (Somatropin); Genotropin (Somatropin); Arimidex (Anastrozole); Femara (Letrozole); Nutropin (Somatropin); Genotropin (Somatropin)
Intervention MeSH terms: Letrozole; Anastrozole; Hormones; Aromatase Inhibitors
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Aromatase; Growth; Letrozole; Anastrozole; GH; Children; Puberty
A Study Evaluating Good Idea on Glucose Homeostasis in a Healthy Population
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      A crossover design to evaluate the safety and efficacy of GoodIdea TM (trademark) on glucose
      homeostasis in a healthy population. Eligible participants will be given either the GoodIdea
      drink or placebo and a standardized meal and will consume both in approximately 15 minutes.
      Blood will be drawn at several time points over a 3 hour period to determine the study
      objectives. After a 7-day washout, the participants will come back to the clinic and and
      complete the visit consuming the opposite product given at the previous visit. The primary
      objective is to see the difference of the two-hour iAUC for intravenous blood glucose between
      the active product (GoodIdea) and the placebo following a standardized meal.
    


Intervention name(s): GoodIdea; Placebo
Intervention type(s): Dietary Supplement; Other
Intervention description(s): Active product. Amount: 355mL. Consumed at a clinic visit over 14 minutes.; Non-active placebo product. Amount: 355mL. Consumed at a clinic visit over 14 minutes.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: glucose; glucose homeostasis
Efficacy and Tolerability of Cassia Fistula Plus Senna Alexandrina Miller (Sugar Free) in the Chronic Functional Constipation (CFC).
Condition: Constipation
MeSH terms: Constipation; Fistula
Study type: Interventional
Phase: Phase 3

Summary: 
      Primary Objective:

        -  To evaluate the clinical efficacy of Naturetti (jelly sugar free)

        -  To test medication on subjects who suffer chronic functional constipation in 30 days
           use.

      Secondary Objectives:

        -  To demonstrate the clinical tolerability when daily used (repeated doses) of the
           components of the study drug. The components will be evaluated by the adverse events
           occurrence classified by possibly related, probably related and definitely related

        -  To demonstrate the clinical tolerability of the study medication by the continuous use
           during the second phase study

        -  To identify any adverse events related to the study drug

        -  To identify any drug interaction.
    


Intervention name(s): SENNA+CASSIA(Naturetti)
Intervention type(s): Drug
Intervention description(s): Daily administration (oral) of one spoon (5g) of Naturetti (SENNA+CASSIA) jelly sugar free at bedtime, during 30 days
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
New Surgical Approach in Labioplasty
Condition: Gynecologic Disease; Surgery-Complications
MeSH terms: Genital Diseases, Female
Study type: Observational

Summary: 
      The data of patients who underwent labiaplasty + vaginoplasty between 2020 and 2022 by a
      single surgeon in our clinic were analyzed. Preoperative and postoperative FSFI (Female
      sexual function index) questionnaire scores were used to compare the results of the classical
      surgical approach and the new surgical approach technique designed according to the Fibonacci
      ratio in the early postoperative period such as operating time, bleeding amount, etc.
    

Detailed description: 
      The data of patients who underwent labiaplasty + vaginoplasty between 2020-2022 for reasons
      such as vaginal laxity, personal hygiene problems, recurrent vaginal infections were analyzed
      retrospectively. The data of the patients who underwent fibonacci ratio, which is a new
      surgical approach technique( by Okuyan E. M.D), and the patients who underwent classical
      surgical technique were taken from their files and retrospectively analyzed. Data including
      age, body mass index, number of live births, preoperative FSFI, FGSIS and postoperative one
      month FSFI (Female sexual function index) and FGSIS (The Female Genital Self-Image Scale)
      scores were recorded and compared between both groups.
    

Intervention name(s): New surgical approach
Intervention type(s): Other
Intervention description(s): Patients were included in the study after obtaining informed consent for the new surgical approach inspired by the Fibonacci ratio.
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Patients who underwent labioplasty plus vajinoplasti prosedures in our clinic (age 18-45
        years old)
      
Keywords: Labioplasty; Vaginoplasty; Fibonacci ratio
Prospective Multicentre Phase-IV Clinical Trial of Olaparib in Indian Patients With Ovarian and Metastatic Breast Cancer
Condition: Ovarian Cancer; Breast Cancer
MeSH terms: Breast Neoplasms; Ovarian Neoplasms; Carcinoma, Ovarian Epithelial
Study type: Interventional
Phase: Phase 4

Summary: 
      A Prospective, Multicentre, Phase-IV Clinical Trial of Olaparib in Indian Patients with
      Platinum Sensitive Relapsed Ovarian Cancer who are in Complete or Partial Response Following
      Platinum based Chemotherapy and Metastatic Breast Cancer with germline BRCA (BReast CAncer
      gene) 1/2 Mutation
    

Detailed description: 
      A Prospective, Multicentre, Phase-IV Clinical Trial of Olaparib in Indian Patients with
      Platinum Sensitive Relapsed Ovarian Cancer who are in Complete or Partial Response Following
      Platinum based Chemotherapy and Metastatic Breast Cancer with germline BRCA(BReast CAncer
      gene)1/2 Mutation As per recommendation from DCGI(Drug Controller general of of India), the
      current phase-IV study is planned with the aim to assess the safety in Indian subjects
      receiving olaparib as per the approved label indications in India in accordance with the
      requirements of the Health Authorities of India. This study attempts to descriptively
      elucidate the safety of Olaparib in Indian subjects receiving olaparib as per the Indian
      regulatory approved indications in India. The data obtained from the present study will help
      to understand the safety profile of olaparib in Indian patients.
    

Intervention name(s): Olaparib
Intervention type(s): Drug
Intervention description(s): Tablet
Intervention MeSH terms: Olaparib
Intervention model: Single Group Assignment
Intervention model description: A Prospective, Multicentre, Phase-IV Clinical Trial
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Ovarian Cancer; Breast Cancer, Olaparib
Effects of COcoa Supplement in FRail Elderly Subjects (COFRE)
Condition: Sarcopenia; Frail Elderly Syndrome
MeSH terms: Sarcopenia
Study type: Interventional

Summary: 
      The study use a double blind, placebo-controlled design enrolling male and female subjects
      between 55-90 yo to evaluate the effect of daily consumption of a cocoa beverage on
      anthropometric, metabolic, oxidative stress, physical performance and quality of life.
    

Detailed description: 
      The study use a double blind, placebo-controlled design enrolling male and female subjects
      between 55-90 yo randomly assigned to consumption of a flavonoid rich mixture (flavonoids;
      F), alkalinized cocoa which eliminates flavonoid content (no flavonoids; NF) or placebo. All
      beverages had similar physical characteristics and flavor. Cocoa beverages were provided in
      individual sachets containing a dry powder that was reconstituted with water just before
      consumption. Subjects were instructed as above to maintain their usual lifestyle, to limit
      intake of high caloric foods and flavonoid-containing foods and beverages, and to walk for 30
      min/day.

      To determine the effect of flavonoids, study evaluates anthropometric measures, metabolic
      parameters as glycemia and a lipid profile (triglycerides, total cholesterol, high-density
      lipoprotein cholesterol and low-density lipoprotein cholesterol). To evaluate oxidative
      stress damage as lipid oxidation is measured with the malondialdehyde (MDA) assay. Protein
      carbonylation is measured using an assay for detection of carbonyl groups that relies on
      2,4-dinitrophenylhydrazine (DNPH) as a substrate. The investigators also evaluate
      interleukin-6 and tumor necrosis factor levels.

      For physical performance is evaluated the handgrip strength, and mobility assesment with the
      following test: Six-minute walk test, two-minute step, sit-up test and the up & go test.

      The investigators also assessed quality of life using the Health Related QoL (EQ-5D)
      questionnaire.
    

Intervention name(s): Placebo; Flavonoids; No Flavonoids
Intervention type(s): Other; Other; Dietary Supplement
Intervention description(s): Beverage with no flavonoids; Flavonoids-enriched cacao beverage; Beverage with alkalinized cocoa which eliminates flavonoid content
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: flavonoids
Study to Evaluate Clinical Efficacy and Safety of Bio Mineral Toothpaste in Patients With Mild Periodontitis
Condition: Periodontitis
MeSH terms: Periodontitis
Study type: Interventional
Phase: Phase 4

Summary: 
      The hypothesis of this study is that using "Bio Mineral" toothpaste for 4 weeks will decrease
      plaque and gingivitis of mild periodontitis patients compared to patients using "Perio Total
      Care" toothpaste.

      This study is Single blind, Randomized, Active-controlled Comparative clinical trial to
      evaluate clinical efficacy and safety following the application for 4 weeks of Bio Mineral
      toothpaste in patients with mild periodontitis.
    

Detailed description: 
      This study is Single blind, Randomized, Active-controlled Comparative clinical trial to
      evaluate clinical efficacy and safety following the application for 4 weeks of Bio Mineral
      toothpaste in patients with mild periodontitis. 30 patients of treatment group and 30
      patients of control group, total 60 patients will be enrolled to this study. Every patients
      will use investigational toothpaste 2 times everyday for 4 weeks and brush their teeth at
      least 3 minutes each time with 1ml of toothpaste.
    

Intervention name(s): Bio Mineral toothpaste; Perio Total Care toothpaste
Intervention type(s): Other; Other
Intervention description(s): Frequency: 2 times everyday/Duration: 4 weeks/Dosage: 1ml at once; Frequency: 2 times everyday/Duration: 4 weeks/Dosage: 1ml at once
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Mild periodontitis; Bio Mineral toothpaste; Geumjin Thermal Water
A Phase I Study to Assess the Effect of Itraconazole and Rifampicin on Pharmacokinetics Profile of BPI-7711
Condition: NSCLC
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a phase I study to assess the effect of itraconazole and rifampicin on the
      pharmacokinetic parameters of BPI-7711 in Chinese healthy volunteers.
    


Intervention name(s): BPI-7711; BPI-7711; Itraconazole; Rifampicin
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): BPI-7711 60 mg; BPI-7711 180 mg; Itraconazole 200 mg; Rifampicin 600 mg
Other intervention name(s): BPI-7711 capsule; BPI-7711 capsule; Itraconazole capsule; Rifampicin capsule
Intervention MeSH terms: Itraconazole; Hydroxyitraconazole; Rifampin
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
A Single-center Study to Investigate How Quickly and to What Extent a Radioactive Dose of RO5285119 is Absorbed, Metabolized and Eliminated From the Body of Healthy Male Volunteers
Condition: Healthy Volunteer
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is designed to investigate the absorption, distribution, metabolism and
      elimination of a single oral dose of radiolabeled [14C]-labeled RO5285119 in healthy male
      participants.
    


Intervention name(s): RO5285119
Intervention type(s): Drug
Intervention description(s): Single oral dose of RO5285119 with approximately 2.1 MBq (56.6 uCi) [14C]-radiolabeled RO5285119 administered as a drinking solution under fasted conditions on Day -1
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Survey of Diet and Health Beliefs
Condition: Dietary Guidelines
Study type: Observational

Summary: 
      The purpose of this research is to better understand people's health and diet knowledge,
      beliefs, attitudes, and practices. The researchers will use this information to implement
      better strategies to help Americans maintain more nutritious diets.
    

Detailed description: 
      The overall goal of this study is to determine whether there are differences in perceptions
      of healthy nutrition messages depending on from whom the message is coming. More
      specifically, the researchers aim to examine whether there are differences in how people
      perceive and intend to follow nutrition information that is coming from a variety of sources.
    

Intervention name(s): Perception of information source
Intervention type(s): Other
Intervention description(s): Participants will see the same health advice, with no source or one of three other sources indicated
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Participants will include American adults aged 18 and over. Minors, i.e., those under 18,
        will be excluded. To participate, people must have access to internet. Therefore, by
        default, those who do not have internet access will be excluded from this study. Due to the
        nature of this study, participants from all over the country will be eligible to
        participate.