The Cohort Study of Cognitive Impairment in Chinese Hemodialysis Patients
Condition: Cognitive Impairment; Hemodialysis Complication; Outcome; Neuropsychological Tests
MeSH terms: Cognitive Dysfunction
Study type: Observational [Patient Registry]

Summary: 
      This study is going to apply neuropsychological battery tests to measure cognitive function
      across multiple cognitive domains in our cohort of 600 maintenance hemodialysis patients and
      evaluate:

        1. The presence and patterns of cognitive impairment in domains of executive function,
           perceptual-motor function, language, learning and memory, and complex attention;

        2. Clinical characteristics of participants with and without cognitive impairment;

        3. the risk factors which might be related to cognitive impairment in this group of
           population;

        4. The association between cognitive impairment and all-cause mortality, stroke and
           non-fatal cardiovascular events;

      We hypothesize that hemodialysis patient is going to have cognitive impairment which might be
      associated with some risk factors. We also anticipate that cognitive impairment might have
      some kind of association with the clinical outcomes like all-cause mortality, stroke and
      other common clinical outcomes that we mentioned above.
    

Detailed description: 
      Neuropsychological assessment All neuropsychological assessments were performed by the
      research staff that was centrally trained and certified by the study neuropsychologist to
      conduct the assessments before study commencement. All research staff and patients were
      native Chinese speakers. Neuropsychological assessment was conducted individually in a
      separate room on the day after a dialysis session and required on average approximately 90
      minutes. Global cognitive function was screened by the Chinese Beijing version of the
      Montreal Cognitive Assessment (MoCA-BJ).10 The comprehensive battery of neuropsychological
      tests was designed to assess five cognitive domains: (1) attention/processing speed, using
      Symbol Digit Modalities Test and the Chinese modified version of the Trail Making Test
      A,11,12(2) executive function, using the Chinese modified version of the Trail Making Tests B
      , and a modified version of the Stroop Color-Word Test;13 (3) verbal memory, using the
      Chinese version of the Auditory Verbal Learning Test for short-delay and long-delay free
      recall14 and Complex Figure for visual memory (delayed recall test; Chinese version);12 (4)
      language, using the Chinese modified versions of Boston Naming Test (the 30-item version) and
      Animal Fluency Test;15,16and (5) visuospatial function, using the Rey-Osterrieth Complex
      Figure (copy test).17,18 Depression was assessed using the Hamilton Depression Scale, with
      scores ranging from 0 to 63 and a score of 7 or above suggested as the optimal cutoff for
      suspected depression.
    

Intervention name(s): cognitive impairment
Intervention type(s): Other
Intervention description(s): one are of patients were exposed to cognitive impairment
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Chinese Maintenace Hemodialysis Patients