The Role of Platelet Rich Plasma Injections in Cases of Stress Incontinence
Condition: Stress Urinary Incontinence; Urinary Incontinence
MeSH terms: Urinary Incontinence; Enuresis; Urinary Incontinence, Stress
Study type: Interventional

Summary: 
      Urinary incontinence can impact on one's social, physical, mental, and sexual wellbeing, and
      lead to depression and social isolation Stress urinary incontinence (SUI) refers to the
      involuntary leakage of urine accompanying physical exertion (i.e. coughing, exercise, and
      sneezing). It is commonly acquired after pregnancy and childbirth due to the weakening of the
      pelvic floor muscles that support the urethra against the anterior vaginal wall.

      Current SUI treatment includes surgery to re-establish sufficient urethral resistance in
      order to prevent urine leakage during increased intra-abdominal pressure.
    

Detailed description: 
      Urinary incontinence can impact on one's social, physical, mental, and sexual wellbeing, and
      lead to depression and social isolation.

      Stress urinary incontinence (SUI) refers to the involuntary leakage of urine accompanying
      physical exertion (i.e. coughing, exercise, and sneezing). It is commonly acquired after
      pregnancy and childbirth due to the weakening of the pelvic floor muscles that support the
      urethra against the anterior vaginal wall.

      Current SUI treatment includes surgery to re-establish sufficient urethral resistance in
      order to prevent urine leakage during increased intra-abdominal pressure.

      The mid-urethral sling (MUS) has become the preferred procedure, as it is less invasive than
      the Burch colposuspension. However, the MUS procedure has a 5-20% failure rate and carries
      risks such as infection, voiding dysfunction, hemorrhage, pain, bladder or urethral injury,
      and mesh erosion.

      Hence, there is a need for alternative efficacious, outpatient SUI treatments.
      Platelet-derived therapies are a growing trend across multiple medical and surgical
      specialties. Evidence suggests that platelets play an important role in tissue repair,
      vascular remodeling and inflammatory and immune responses through secretion of growth
      factors, cytokines, and chemokines.

      These biologically active proteins include transforming growth factor-β, platelet-derived
      growth factor, platelet-derived epithelial growth factor, insulin-like growth factor,
      vascular endothelial growth factor. These growth factors are implicated in many aspects of
      natural wound healing, including chemotaxis, cell proliferation, cell differentiation. The
      key role of platelets in these processes makes them an attractive candidate for therapies
      aimed at accelerating natural healing.

      One of the most well-described platelet-based therapies is autologous platelet-rich plasma
      (PRP). PRP is derived from the centrifugation of whole blood with a separator gel to remove
      the red and white blood cells. The resulting supernatant has a greater than four-fold
      increase in platelets and other plasma proteins. This concentrate is then administered via
      injection.
    

Intervention name(s): platelet rich plasma
Intervention type(s): Procedure
Intervention description(s): Injection of Platelet Rich Plasma in the female conditions that suffer from SUI
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment