Detection and Application of Organic Disease With Phonocardiac Spectrometry
Condition: Phonocardiography
Study type: Observational [Patient Registry]

Summary: 
      Western medicine, as to disease detection, is based on histological pathology and organ
      anatomy, therefore biochemistry and medical imageology were developed to determine the
      location and mechanism of the sickness. Chinese medicine, in the other way around, follow the
      harmony between man and nature, creating four ways of diagnosis, namely looking, listening,
      questioning and pulse feeling, which evaluate the physiological homeostasis by the yin-yang
      of qi and blood, further judging the energy exchange between individual and the universe.
    

Detailed description: 
      Western medicine, as to disease detection, is based on histological pathology and organ
      anatomy, therefore biochemistry and medical imageology were developed to determine the
      location and mechanism of the sickness. Chinese medicine, in the other way around, follow the
      harmony between man and nature, creating four ways of diagnosis, namely looking, listening,
      questioning and pulse feeling, which evaluate the physiological homeostasis by the yin-yang
      of qi and blood, further judging the energy exchange between individual and the universe.

      Pulse sound provides perfect detection of disease in Chinese medicine. Hence we plan to
      digitalize the pulse sound for a better interpretation of the sickness. According to past
      studies of pulse sound from radial artery, the lower frequency is below 25Hz, which falls
      into the detection range of Messener's corpuscles (2-80Hz), which are located intensively in
      index and middle fingers. However, radial artery is relative thinner and the pulse sound is
      not easy to target by the microphone, not to mention the interference from artery sclerosis.
      To this end our research group developed Phonocardiac spectrometry (PCS) to replace the
      traditional pulse instrument.

      Since heart beats continuously, we hypothesize that each organ is regularly sending the
      signal back to heart, which modulate the contraction and beating of heart, reflecting
      different state of each organ. Heart is just like the commander of an orchestra band, who can
      direct the rhythm and style of the band by the music score and instruments. Once the
      instrument is damaged, the commander (heart) also adjusts himself. PCS can easily locate the
      pulse sound, and directly detect and analyze the cardiac spectrum. The real-time state in
      heart-organ axis can be readily monitored, recorded and investigated by PCS.

      Our preliminary analysis focuses on patients with liver and pancreatic cancers. The results
      demonstrate the different pattern of cardiac spectrum between patients and normal people,
      which can be further sorted by disease types. By applying PCS measurement and the novel
      algorithm calculation to various diseases, we aim to build up a novel platform for disease
      screening or even diagnosis.
    

Intervention name(s): phonocardiac spectrometry
Intervention type(s): Diagnostic Test
Intervention description(s): Detection and application of organic disease with phonocardiac spectrometry
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Volunteer, out- and in-patients in gastroenterology division of Wanfang hospital.
      
Keywords: phonocardiac spectrometry, organic disease