bioihbjkbjnl/mcl2 huggingface dataset:
Comparation Analgesia Efficiency With Propofol Combine Sevoflurane vs Propofol
Condition: Nociceptive Pain; Analgesic Adverse Reaction; Inhalant Use
MeSH terms: Nociceptive Pain
Study type: Interventional
Phase: Phase 3

Summary: 
      This study purpose to compare analgesia efficiency of propofol combine with sevoflurane with
      propofol only using index of Nociception (NOX)
    

Detailed description: 
      1. Recently study found sevoflurane plays an important role through spinal nerve peptide
           receptor (NK.1R), glycine receptor (GlyR), neuron nicotinic receptor (nnAChRs),
           Methyl-1-methyl-1-day aspartate (NMDA receptor), and TRPV1 receptor (TRPV1 receptor)
           produce the analgesic efficiency.

        2. propofol was traditional sedation reagent.

        3. index of Nociception (NOX) was the objective index for analgesia This study purpose to
           compare analgesia efficiency of Only Propofol and sevoflurane combine with propofol
           using index of Nociception (NOX)
    

Intervention name(s): 5mg/kg/h Propofol; Sevoflurane; 2 mg/kg/h Propofol
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 5mg/kg/h Propofol continuously infused during intre-operation; 1% Sevoflurane continuously using during intre-operation.; 2mg/kg/h Propofol continuously infused during intre-operation
Other intervention name(s): 5mg/kg/h Propofol Injection; 1% Sevoflurane
Intervention MeSH terms: Propofol; Sevoflurane
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Health Services Research
Role of Regulatory B Cells in Behçet's Disease
Condition: Behcet Disease
MeSH terms: Behcet Syndrome
Study type: Observational

Summary: 
      There are limited data about the role of regulatory B cells in Behcet Disease. In this study
      we aimed to identify the proportions of total B lymphocytes and their regulatory subset in
      different Behcet Disease phenotype and therapies concentrating on the cardiovascular system
      attempting to unravel their function in Behcet Disease.
    

Detailed description: 
      Behçet's disease is a chronic multi-organ vasculitis characterized by recurrent oral and
      genital aphthae, skin lesions, widespread thrombosis and aneurysmal formation, and serious
      involvement of the eyes and central nervous system.

      The innate and adaptive immune cells integrate in the pathogenesis of Behçet's disease.
      Interestingly, the gene expression analysis of Behçet's disease patients and healthy controls
      revealed the modulation of a range of genes involved in biological processes in Behçet's
      disease such as inflammation, apoptosis, angiogenesis, blood coagulation, vascular damage,
      signalling pathways, and immune responses, particularly, in innate immune cells, Th17 cells
      and B cells. Yet, the regulatory role of B cells in Behçet's disease has not been thoroughly
      investigated. Therefore, the aim of the current study is to identify the proportions of total
      B lymphocytes and their regulatory subset in different Behçet's disease phenotypes and
      therapies attempting to unravel their function in Behcet Disease. The role of B cells and
      regulatory B cells in the cardiovascular system affection in Behcet Disease was studied in
      more details.
    

Intervention name(s): Flow-cytometric assay; 2D Echocardiographic analysis; Two-Dimensional speckle tracking echocardiography
Intervention type(s): Diagnostic Test; Diagnostic Test; Diagnostic Test
Intervention description(s): 100 µl of blood sample was incubated for 20 minutes at 4 C in the dark. Following incubation, red blood cells lysis, washing and analysis a specific software.Forward and side scatter histogram was used to define the lymphocytes population.; Trans thoracic echocardiographic examination was performed through (PHILIPS -33) echocardiography device with broadband S5-1 transducer; Two-Dimensional speckle tracking echocardiography was performed on grey scale images of the left ventricle. For offline analysis digital storage software (Qlab 10.4) was used. The frame rate was adjusted to be 60-90 frame/second.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Thirty five adult patients who fulfilled the diagnostic criteria of Behcet Disease, and 39
        age and sex matched healthy subjects as control
A Low-fat Diet Combined With Moderate-intensity Aerobic Exercise Versus Low-fat Diet, Aerobic Exercise Alone on Dyslipidemia and Depression Status in Obese Patients
Condition: Dyslipidemias
MeSH terms: Dyslipidemias
Study type: Interventional

Summary: 
      It was defined that exercise and dietary interventions are used to control dyslipidemia and
      depression in obese individuals, whilst rare investigations have examined the concurrent
      effects of a low-fat diet and moderate-intensity aerobic exercise training (MIAET) on
      dyslipidemia and depression in obese patients. Hence, we assessed the potential influences of
      a low-fat diet combined with MIAET on blood lipids and depression in those individuals.
    


Intervention name(s): Moderate-intensity aerobic exercise training
Intervention type(s): Other
Intervention description(s): The first group has received Moderate-intensity aerobic exercise training without dietary control, the second group has received a low-fat diet program without exercise intervention, and the third group has received Moderate-intensity aerobic exercise training plus a low-fat diet program for 10 consecutive weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Peanuts and Glycemic Control
Condition: Type2 Diabetes; Cardiovascular Diseases
MeSH terms: Cardiovascular Diseases
Study type: Interventional
Phase: Phase 2

Summary: 
      A two-period randomized crossover study will be conducted to determine the effect of peanuts
      on glycemic control, and elucidate the role of the microbiome in glucose regulation, in
      individuals with impaired fasting glucose.
    

Detailed description: 
      A two-period randomized crossover trial will be conducted. Participants will be randomized to
      receive each treatment for 6 weeks followed by a minimum 4-week wash-out period. During the
      peanut treatment, participants will consume one ounce per day (28 g) of peanuts as an evening
      snack. The control treatments will be an isocaloric higher carbohydrate snack consumed after
      the evening meal. Markers of glycemic control, cardiovascular risk factors and gut health
      will be assessed at the beginning and the end of each treatment period.
    

Intervention name(s): Peanut; High carbohydrate snack
Intervention type(s): Drug; Drug
Intervention description(s): Roasted, unsalted peanuts will be purchased from a local grocery store and provided to subjects to consume.; Whole wheat crackers will be purchased from a local grocery store and provided to subjects to consume with a spread (e.g. cream cheese or margarine).
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Investigator)
Primary purpose: Prevention
Effectiveness of Manual Therapy and Strengthening Exercises in Hemophilic Arthropathy of the Elbow Joint
Condition: Hemophilia; Arthritis
MeSH terms: Joint Diseases; Hemophilia A
Study type: Interventional

Summary: 
      Manual treatment involves techniques based on the principles of moving the joint faces and
      separating the joint gap, and soft tissues mobilization techniques. The use of manual therapy
      in hemophilia is gradually increasing although it previously described as a contraindication.
      The utility and use of strengthening exercises in hemophilia has been going on for a long
      time. In this study, the effect of manual therapy and strengthening exercises joint was
      investigated in hemophilic arthropathy of the elbow.
    

Detailed description: 
      The aim of this study was to investigate the effects of strengthening exercises and manual
      therapy on bleeding frequency, pain, range of motion, muscle strength, arm circumference,
      joint health, functionality and quality of life in the physiotherapy and rehabilitation of
      hemophilic arthropathy of the elbow. Seventeen adolescent and young adult hemophilic
      individuals aged 12-30 years with elbow arthropathy were included in the study. The
      individuals were divided into the two groups via simple randomisation as Manuel Therapy and
      Exercise Group (MTEG) and Home Exercise Group (HEG). The individuals in HEG were given
      strengthening exercises as a home program. Those in the MTEG were applied manual therapy by
      the physiotherapist and were given supervised strengthening exercises. All treatments were
      performed 3 times a week for 5 weeks totally 15 sessions. Frequency of bleeding was evaluated
      with number of bleeding in the last 5 weeks. Numerical Pain Scale was used for activity and
      resting pain. Range of motion and muscle strength were measured with universal goniometer and
      digital dynamometer, respectively. The Quick-DASH questionnaire and Oxford Elbow Score were
      used for the functionality of the upper extremity and quality of life, respectively. The
      joint health status was evaluated with Hemophilia Joint Health Score-Elbow Point and Hospital
      for Special Surgery-Elbow Scoring System. Evaluations were made by the same physiotherapist
      before and after treatment.
    

Intervention name(s): Manual therapy; Strengthening exercises
Intervention type(s): Other; Other
Intervention description(s): Manual therapy includes techniques applied to elbow joints and surrounding tissues; Strengthening exercises used in this study includes resistant exercises to increase muscle strength of upper extremity
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Hemophilia; Arthropathy; Elbow joint; Manual therapy; Exercise
Evoked Fields After Median and Ulnar Stimulation
Condition: Complex Regional Pain Syndromes
MeSH terms: Complex Regional Pain Syndromes; Reflex Sympathetic Dystrophy; Syndrome
Study type: Observational

Summary: 
      In order to be able to study the effects of evoked fields with magnetoencephalography (MEG)
      in two groups of patients, comparison is made with a group of healthy volunteers.
    

Detailed description: 
      This study is directed at the (central and / or peripheral) mechanisms of pain and the
      cortical changes (plasticity) due to chronic non-malignant pain in two groups of patients and
      one healthy volunteer group.

      The aim of the study is further to evaluate cortical processes by MEG (and fMRI, if feasible)
      to quantify and qualify the responses, localise the generators and study the effects of a
      pain therapy.

      To search for patterns that may result in diagnostic criteria and have an indicative value
      for the treatment and the monitoring of the effects.

      Finally the study not only intends to support clinical diagnosis but also to provide tools to
      monitor treatment and support the choice (algorithm) between SCS and SAN. An algorithm,
      facilitating decision making between these two treatments, will be promoted. It should also
      provide a clinical decision tool for the use of SAN
    

Intervention name(s): Evoked fields before and after a local block (Xylocaine)
Intervention type(s): Other
Intervention description(s): MEG registration after electrical median and ulnar nerve stimulation in subjects and patients. In the patient group another MEG was performed after an anaesthetic block (1-2 ml Lidocaine 1%) at the site of the nerve injury producing a painfree state
Other intervention name(s): All subjects were rated with the HC code, 1 to 20; All patients with nerve injury were rated with the A - code, 1 to 20; All patients with CRPS I were rated with the C - code, 1 to 20
Intervention MeSH terms: Lidocaine
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        subjetcs were sampled from the hospital staff of two hospitals all patients were recruited
        from one hospital
      
Keywords: Pain; Magnetoencephalography; Median; Ulnar; Causalgia; Complex regional pain syndrome; Evoked fields; Nerve injury; Neuropathic pain
Copeptin in Normal- to Hyperosmolar States
Condition: Copeptin Blood Values
MeSH terms: Diabetes Insipidus
Study type: Interventional

Summary: 
      Kinetics of Copeptin in response to osmotic alterations in healthy volunteers
    

Detailed description: 
      Construction of the standard area of copeptin release in the normo- and hyperosmolar state
      and its half-life based on ist decline during hypoosmotic Suppression in healthy volunteers.
    

Intervention name(s): Hypertonic saline infusion
Intervention type(s): Other
Intervention model: Single Group Assignment
Masking: None (Open Label)
Motivational Interviewing Integrated With Social Network Counseling for Teens
Condition: Substance Use
MeSH terms: Substance-Related Disorders
Study type: Interventional

Summary: 
      The purpose of this research is to test the feasibility and efficacy of a brief (one session)
      preventative intervention using motivational interviewing integrated with social network
      counseling for substance use among adolescent patients in a primary care setting. One hundred
      participants will be randomly assigned to either motivational interviewing integrated with
      social network counseling or attention control conditions. The motivational interviewing
      integrated with social network counseling condition is expected to show improvement when
      compared to the attention control condition.
    


Intervention name(s): Motivational Interviewing w/Social Network Counseling; Active Control Condition
Intervention type(s): Behavioral; Behavioral
Intervention description(s): This is the active arm of the study.; 20-minute health counseling
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Feasibility, Tolerability and Efficacy of the Ketogenic Diet in Children With Drug-resistant Epilepsy in South Vietnam
Condition: Drug Resistant Epilepsy; Ketogenic Diet; Feasibility; Tolerability; Efficacy; Children
MeSH terms: Epilepsy; Drug Resistant Epilepsy
Study type: Interventional

Summary: 
      According to the World Health Organization, more than 50 million people have epilepsy. Among
      them, nearly 80% of epileptic patients live in developing countries and 75% of them do not
      have access to treatment. The ketogenic diet (KD) has been shown as an effective alternative
      for patients with drug-resistant epilepsy. Although it has been studied by few studies in
      Asia, no such studies have been conducted in Vietnam. The purpose of this study was to verify
      the feasibility, tolerability, and efficacy of the KD in children with refractory epilepsies
      followed at a pediatric center in South Vietnam.
    

Detailed description: 
      Children with drug-resistant epilepsy followed at Children's Hospital No.2, Viet Nam treated
      by KD were included in a prospective study from June 2019 to October 2021. Side-effects,
      retention rate, number, and duration of seizures were recorded after 1, 3, 6, 9, and 12
      months of KD. Patients were considered as responders when a 50% seizure frequency was
      reached. Tolerance and acceptability of the KD were closely monitored.
    

Intervention name(s): Ketogenic diet
Intervention type(s): Dietary Supplement
Intervention description(s): The ketogenic diet (KD) has been shown as an effective alternative for patients with drug-resistant epilepsy
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Intervention model description: Children with drug-resistant epilepsy followed at Children's Hospital No.2, Viet Nam treated by KD were included in a prospective study from June 2019 to October 2021. Side-effects, retention rate, number, and duration of seizures were recorded after 1, 3, 6, 9 and 12 months of KD. Patients were considered as responder when a 50% seizure frequency was reached. Tolerance and acceptability of the KD were closely monitored.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: drug resistant epilepsy; ketogenic diet
Influence of Umbilical Cord Clamping Time in the Newborn
Condition: Anemia Neonatal; Polycythemia Secondary; Hyperbilirubinemia, Neonatal
MeSH terms: Neoplasm Metastasis; Polycythemia; Anemia, Neonatal; Hyperbilirubinemia, Neonatal; Hyperbilirubinemia
Study type: Interventional

Summary: 
      This study compares two umbilical cord clamping times; the early one, up to a minute (ECC)
      and the late or delayed one, when the cord stop beating (DCC). The additional blood volume
      delivered to the newborn from the placenta - placental transference - by delaying umbilical
      cord ligation, increases the contribution of neonatal iron with increased iron stores in the
      infant, without increasing neonatal morbidity.
    

Detailed description: 
      It is an intervention study without drugs administration with a longitudinal, prospective
      comparison and correlational design.

      Patients are recruited by simple random sampling to one of the two intervention groups:

      Group 1-ECC: Early clamping of the umbilical cord (before the first minute of life).

      Group 2-DCC: Delayed clamping of the umbilical cord (when it stops beating).
    

Intervention name(s): ECC; DCC; Blood Test 6hours; Blood Test 24hours; Blood Test 48hours; Blood Test 28days
Intervention type(s): Procedure; Procedure; Procedure; Procedure; Procedure; Procedure
Intervention description(s): Early clamping of the umbilical cord; Delayed clamping of the umbilical cord; Blood Test 6hours; Blood Test 24hours; Blood Test 48hours; Blood Test 28days
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomised controlled trials comparing early and late cord clamping
Masking: None (Open Label)
Primary purpose: Other
Keywords: Umbilical cord clamping; Anemia Neonatal; Iron metabolism disorders
Effects of Different Surgical Methods to Treat Obesity
Condition: Obesity; Type 2 Diabetes; Insulin Sensitivity
MeSH terms: Obesity; Insulin Resistance; Hypersensitivity
Study type: Interventional

Summary: 
      Obese patients have an increased risk for developing severe metabolic disorders. This risk
      can only partly be reduced by weight reduction. The investigators have in a pilot study
      investigated if removal of abdominal fat (visceral) in addition to weight loss has additional
      beneficial effects on the metabolic profile and weight loss. This study aims to further
      investigate if removal of abdominal fat (major omentum) leads to beneficial metabolic
      effects.
    


Intervention name(s): Omentectomy; Gastric bypass operation
Intervention type(s): Procedure; Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Obesity; Bariatric Surgery; Insulin Sensitivity
Inhaled Beta-2 Agonist Versus Epinephrine For Treatment of Transient Tachypnea of Newborn (TTN)
Condition: Transient Tachypnea of the Newborn
MeSH terms: Tachypnea; Transient Tachypnea of the Newborn
Study type: Interventional
Phase: Phase 1

Summary: 
      Inhaled Beta-2 Agonist Versus Epinephrine For Treatment of Transient Tachypnea of Newborn:
      Randomized controlled trial to assess:
    

Detailed description: 
      This is a randomized double-blind randomized controlled trial. It had been conducted at the
      Neonatal Intensive Care Unit (NICU) of Mansoura University Children's Hospital, Egypt Written
      informed consent had been taken from all parents whose infants were recruited in the study.
      The ethics committee of the faculty of medicine has approved the study.
    

Intervention name(s): Epinephrine Inhalation Solution; Salbutamol; Saline Inhalants
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: Epinephrine; Albuterol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Transient Tachypnea of the Newborn (TTN); epinephrine; salbutamol; respiratory distress; newborn
The Effect of North American Ginseng on Blood Pressure in Individuals With Hypertension
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional
Phase: Phase 3

Summary: 
      To determine the effect of North American ginseng on blood pressure in individuals with
      hypertension.
    

Detailed description: 
      Ginseng lacks proper clinical scrutiny for its effect on blood pressure (BP), in spite of
      observational evidence linking its intake to hypertension. This should be addressed
      considering the potential overlap between the prevalence of ginseng use and hypertension.

      We undertook a single centre, randomized, controlled, double-blinded, crossover trial to
      determine the effect of North American ginseng (NAG) on 24-hour BP and renal function. After
      a 4-week placebo run-in, we randomly assigned participants to NAG or placebo treatment for
      12-weeks at a dose of 3g/day. This was followed by an 8-week washout, and a subsequent
      12-week period in which the opposite treatment was consumed. At run-in, and at weeks 0 and 12
      of each treatment period, participants were fitted with an ambulatory BP monitor to assess
      24-hour BP and serum cystatin C was measured.
    

Intervention name(s): North American Ginseng (Panax Quinquefolius)
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Hypertension; Blood Pressure; Ambulatory Blood Pressure Monitoring; Complementary and Alternative Medicine; Herbal; North American Ginseng; Panax Quinquefolius
A Functional Magnetic Resonance Imaging (fMRI) Study in Overweight and Obese Men (0000-103)
Condition: Obesity
MeSH terms: Overweight
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will determine whether BOLD-fMRI can be used to probe hunger and satiety states in
      healthy overweight or obese men and also whether fasted/fed fMRI signals can be modulated by
      sibutramine.
    


Intervention name(s): Placebo; Comparator: sibutramine
Intervention type(s): Drug; Drug
Intervention description(s): Single dose placebo to sibutramine in two of three treatment periods.; Single dose sibutramine 30 mg (2 x 15 mg) in one of three treatment periods.
Other intervention name(s): sibutramine
Intervention MeSH terms: Sibutramine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Diagnostic