Brain Changes in Adolescents While Imagining and Observing Aggressive Behavior
Condition: Aggressive Behavior
MeSH terms: Aggression
Study type: Observational

Summary: 
      This study will use functional magnetic resonance imaging (fMRI) to examine what happens in
      the brains of adolescents when they are exposed to violent media and how imagining aggressive
      behavior affects brain function. The study will measure physiological changes (such as the
      amount of electricity generated by the skin, heart rate, and breathing rate) related to these
      tasks during fMRI. MRI uses a magnetic field and radio waves to obtain images of body organs
      and tissues. For fMRI, the subject performs certain tasks during the MRI scanning to examine
      changes in the brain regions that are involved with those tasks. During the scan, the subject
      lies in a metal cylinder (the scanner), wearing earplugs to muffle loud noises that occur
      with the scanning.

      Healthy right-handed native English-speaking males between 14 and 17 years of age may be
      eligible for this study. Candidates are screened with a neurological examination and
      neuropsychological testing that includes questions about their feelings, experiences, and
      behavior, and tests of reading level and intelligence.

      Participants undergo fMRI and fill out questionnaires before and after the scanning. Some
      children are asked to play 20 minutes of video games before the test. During the scan, the
      child views short neutral video clips and video clips of people fighting or imagine
      self-defense situations. The child is asked to rate the video clips for their aggressive
      content or tell how he or she feels about the imagined situations. Two small straps are
      wrapped around the child's index and middle fingers to measure changes in the amount of
      electricity generated by the skin, and a strap at the ring finger measures the child's heart
      rate. A band around the child's chest records breathing rates.

      Children who cannot or do not want to undergo MRI testing may be asked to view commercially
      available video clips of people fighting and neutral video scenes, such as sports scenes.
      They are asked to rate them on their violent content and excitement, or to rate the video
      games they have played on their violent/nonviolent content and their popularity. In addition,
      the children fill out questionnaires about their media use and exposure to violence.

      All participating families are contacted by telephone 1 day and 2 weeks after the experiment
      for parents to answer questions about how the child has been doing and for the children to
      answer questions about their feelings.
    

Detailed description: 
      Objective. The purpose of the protocol is to localize the prefrontal cortical regions
      mediating aggressive behavior. Utilizing two different experimental neuropsychological tasks
      during functional MRI, we will investigate hypotheses regarding the role of the ventro-medial
      prefrontal cortex in processing imagined and observed aggressive behavior. Additionally, we
      will determine the relationship between non-frontal neural structures involved in emotional
      expression, such as the amygdala, and the prefrontal structures involved in executive
      functions that may modulate aggressive behavior. We will record skin conductance responses
      (SCRs), heart rates, and respiration during the experiments to investigate autonomic changes
      during the processing of aggressive behavior.

      Study Population. In three separate studies, normal adolescent volunteers will participate in
      experiments dealing with processing of aggressive behavior using functional magnetic
      resonance imaging (fMRI). In addition, we will conduct two pre-studies in normal adolescent
      volunteers in order to determine appropriate stimuli for the fMRI studies.

      Design. The experiments we are conducting will employ within-subject, rapid event-related
      fMRI designs to determine whether the observation and imagination of aggressive behavior
      deactivates the ventro-medial prefrontal cortex (VM-PFC) and how varying intensities of
      imagined and observed aggressive acts may influence changes in activation patterns in the
      VM-PFC.

      Outcome Measures. The data collected will consist of fMRI activation images corresponding to
      varying intensities of observed or imagined aggression, questionnaire results, amplitudes of
      the skin conductance responses, heart rates, and respiration parameters. The results gained
      from this protocol will provide further evidence for the role of the ventro-medial prefrontal
      cortex in processing aggressive behavior, particularly in adolescents.
    

Keywords: Healthy Control Subjects; Aggression; Prefrontal Cortex Function; Children and Adolescents; Healthy Volunteer; HV