Topical Calcipotriol /Betamethasone Ointment in the Treatment of Plaque Psoriasis
Condition: Psoriasis Vulgaris; Fractional CO2 Laser
MeSH terms: Psoriasis
Study type: Interventional

Summary: 
      comparing the clinical efficacy of topical ointment containing calcipotriol and betamethasone
      dipropionate used alone with the simultaneous use of fractional carbon dioxide laser and the
      same topical ointment containing these two ingredients as treatment modalities for plaque
      psoriasis. Additionally, looking into how both therapy modalities affect individuals with
      psoriasis in terms of how their quality of life is improved.
    

Detailed description: 
      Psoriasis is a widespread, persistent papulosquamous skin condition that can affect anyone at
      any age and places a heavy strain on both the individual and society. It is linked to a
      number of serious medical disorders, such as cardiometabolic syndrome, depression, and
      psoriatic arthritis (1).

      Patients with psoriasis indicate that the condition interferes with their ability to sleep
      and rest, limits their everyday activities, particularly their mobility, and stigmatises them
      and causes problems in their social lives. Additionally, psoriasis can negatively impact
      mental health. Many psoriasis sufferers struggle with addiction, anxiety, and depression (2,
      3).

      Topical medicines continue to be the basis of treatment for those with mild psoriasis, and
      they include topical corticosteroids, vitamin D analogues, calcineurin inhibitors, and
      keratolytics (4).

      For the topical management of mild psoriasis, preparations containing calcipotriol in
      combination with betamethasone (in the form of betamethasone dipropionate) are available (5).
      In comparison to the effects of these active substances when given separately,
      pharmacodynamic investigations demonstrated the synergy between the anti-inflammatory and
      immunoregulatory actions of calcipotriol and betamethasone dipropionate (6). The synergistic
      activity of the two drugs is what makes calcipotriol/betamethasone dipropionate combinations
      successful. Betamethasone impacts inflammatory processes and lessens skin irritation and
      pruritus following calcipotriol administration, while calcipotriol alters keratinocyte
      differentiation (7).

      Fractional lasers were used in the treatment of dermatological diseases. They create tiny
      ablation channels in the skin that act as shunts for topically applied medications,
      particularly those with high molecular weights (8), by ablation of the skin in the form of
      fractions and splitting laser beams into microbeams (9).
    

Intervention name(s): Topical Ointment containing Calcipotriol 0.05 mg/gm and Betamethasone dipropionate 0.5 mg/gm; Fractional carbon dioxide (CO2) laser
Intervention type(s): Drug; Device
Intervention description(s): using topical ointment containing calcipotriol and betamethasone dipropionate for plaque psoriasis.; fractional CO2 laser sessions once per month for 3 months over a similar psoriatic plaque
Intervention MeSH terms: Betamethasone; Betamethasone Valerate; Betamethasone-17,21-dipropionate; Betamethasone benzoate; Calcipotriene; Betamethasone sodium phosphate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: psoriasis vulgaris; fractional CO2 laser; Calcipotriol /Betamethasone Ointment