bioihbjkbjnl/mcl2 huggingface dataset:
Median Nerve Hydro-dissection Using Single Injection of Hyalase as a Novel Treatment of Carpal Tunnel Syndrome
Condition: Carpal Tunnel Syndrome; Pain, Chronic
MeSH terms: Carpal Tunnel Syndrome; Syndrome; Chronic Pain
Study type: Interventional

Summary: 
      Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy, this study aims to
      investigate if, and to what extent hydro-dissection hyalase and saline of the median nerve
      could offer symptoms and clinical improvement
    

Detailed description: 
      Carpal tunnel syndrome (CTS) is the most common compression syndrome the upper extremities.
      Its problem has a high prevalence ranged estimated prevalence of 3.8% in the general
      population, 3 and 7.8% in the working population. It occurs at any age, especially in
      individuals in their 40s to 60s, and the male: female ratio is reported to be 3:7. A lot of
      treatment modalities have been tried to improve the condition, starting from local anesthetic
      injection, steroid, and up to surgical decompression of the nerves.
    

Intervention name(s): Hylase; Saline
Intervention type(s): Drug; Drug
Intervention description(s): median nerve hydro-dissection using Hyalase + 10 cc saline injection; median nerve hydro-dissection using 10 cc saline injection
Other intervention name(s): ( group I ); (group II)
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Investigate if, and to what extent, hydro-dissection using Hyalase versus saline, under ultrasound guidance, can improve the clinical condition, change in nerve conduction parameters of patients with CTS and delay or avoid the surgical intervention.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Phase I of Human Papillomavirus (HPV) DNA Plasmid (VGX-3100) + Electroporation for CIN 2 or 3
Condition: Papillomavirus Infections
MeSH terms: Papillomavirus Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      DNA vaccines, which are small pieces of DNA also known as plasmids, have several advantages
      over traditional vaccines such as live attenuated virus and recombinant protein-based
      vaccines. DNA vaccines appear to be well tolerated in humans. Therefore, we have developed
      our DNA vaccine, VGX-3100, to include plasmids targeting E6 and E7 proteins of both HPV
      subtypes 16 and 18. We have chosen to deliver our candidate vaccines via electroporation (EP)
      using the CELLECTRA™ constant current device to deliver a small electric charge following
      intramuscular (IM) injection, since animal studies have shown that this delivery method
      increases the immune response to our DNA vaccine leading to a decrease in the size of tumors
      caused by HPV 16 and 18. The vaccine is proposed to be given to patients with a history of
      CIN 2 and 3 that have been treated by surgery. We will determine which dose the DNA vaccine
      will be the best tolerated and elicit the strongest immune response.
    


Intervention name(s): VGX-3100
Intervention type(s): Biological
Intervention description(s): DNA plasmid delivered via IM injection + electroporation using CELLECTRA device
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: CIN 2 or 3; cervical cancer
Pharmacokinetics of C6 Ketone Di-ester
Condition: Pharmacokinetics
Study type: Interventional

Summary: 
      Randomized, parallel repeat dose pharmacokinetic study of C6 ketone di-ester in a ready to
      drink beverage matrix.
    

Detailed description: 
      Recruiting 33 healthy adults to participate in a pharmacokinetic (PK) study of C6 ketone
      di-ester in a ready to drink beverage matrix. Following randomization, subjects will
      participate in a full day of PK sample collection prior to being sent home with study product
      for 1 week. After 1 week of daily consumption, subjects will return to the clinic for a
      second PK study identical to the first. Blood samples will be collected for 8 hours following
      test product consumption on both PK days.
    

Intervention name(s): C6 ketone di-ester
Intervention type(s): Dietary Supplement
Intervention description(s): C6 ketone di-ester
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized, parallel, open label study with assessor masked
Masking: Single (Outcomes Assessor)
Primary purpose: Basic Science
Keywords: healthy adults
Efficacy of the "Атопик Soothing Cream" in Children With Mild to Moderate Atopic Dermatitis
Condition: Atopic Dermatitis
MeSH terms: Dermatitis, Atopic; Dermatitis; Eczema
Study type: Interventional

Summary: 
      A Double-Blind Randomized Placebo-Controlled Trial to Evaluate the Efficacy of the "Атопик
      Soothing Cream" in Children with Mild to Moderate Atopic Dermatitis
    

Detailed description: 
      "Атопик Soothing Cream" is a lipid complex composed of barley grain, Butyrospermum Parkii and
      Argania Spinosa Kernel oil, in a mixture with panthenol and bisabolol.

      Investigators concure that combination of these substances in "Атопик Soothing Cream" will be
      efficacious non-steroidal treatment of Atopic Dermatiti ( AD).
    

Intervention name(s): "Атопик Soothing Cream"; Placebo
Intervention type(s): Device; Device
Intervention description(s): Topical application of a study cream to involved skin areas twice a day.; Topical application of a study placebo cream to involved skin areas twice a day.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Atopic Dermatitis; Topical therapy
Bioequivalence Study of Paricalcitol Capsules, 4 mcg Under Fasting Conditions
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      An open-label, balanced, randomized, two-treatment, two-sequence, two-period, single-dose,
      crossover oral bioequivalence study in healthy subjects under fasting conditions.
    

Detailed description: 
      An open-label, balanced, randomized, two-treatment, two-sequence, two-period, single-dose,
      crossover oral bioequivalence study of Paricalcitol Capsules 4 mcg of Dr. Reddy's
      Laboratories Limited and Zemplar® Capsules 4 mcg of Abbott Laboratories, USA in healthy,
      adult, human subjects under fasting conditions.
    

Intervention name(s): Paricalcitol Capsules, 4 mcg
Intervention type(s): Drug
Intervention description(s): Paricalcitol Capsules, 4 mcg of Dr. Reddy's Laboratories Limited
Other intervention name(s): Zemplar
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effects of Cognitive Training on Academic Task Performance in Attention Deficit Hyperactivity Disorder (ADHD)
Condition: ADHD; Attention
MeSH terms: Attention Deficit Disorder with Hyperactivity
Study type: Interventional

Summary: 
      Impaired WM is a central deficit in ADHD. A computerized training program, Cogmed, has been
      shown to increase WM capacity in children with ADHD. It is not known whether the training
      improves behavior associated with classroom learning, such as remaining on-task and
      inhibiting off- task behavior. The aim of this study is to utilize ecologically valid
      measures to investigate training's effect on observable ADHD behavior in conjunction with
      more standard measures. Subjects will be randomly assigned to a Cogmed versus an active
      "placebo" condition in which the tasks do not increase in difficulty level in a
      double-blinded fashion. The effects of the active Cogmed versus placebo computer training
      will be compared on measures in children with ADHD.
    


Intervention name(s): Cognitive training; Cognitive training-placebo
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Cognitive computerized training for several days per week.; Cognitive training that only minimally increases in difficulty
Other intervention name(s): Cogmed; Cogmed placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Cognitive training
A Study of LY3305677 in Participants With Obesity Or Overweight
Condition: Overweight; Obesity
MeSH terms: Obesity; Overweight
Study type: Interventional
Phase: Phase 1

Summary: 
      The main purpose of this study is to learn about the safety and tolerability of LY3305677
      when given to participants with obesity or overweight. Blood tests will be performed to
      investigate how the body processes the study drug and how the study drug affects the body.
      Each enrolled participant will receive injections of LY3305677 or placebo given just under
      the skin. For each participant, the study will last about approximately 28 weeks.
    


Intervention name(s): LY3305677; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Administered SC; Administered SC
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Photographic Assessment of Eyebrow Position and Range of Motion
Condition: Brow Ptosis
MeSH terms: Prolapse
Study type: Observational

Summary: 
      Forehead and eyebrow surgery is a frequently performed cosmetic surgical procedure in which
      the eyebrows are raised to a more aesthetically pleasing position. Typically, this position
      is judged by the surgeon pre-operatively based on traditional aesthetic concepts, some of
      which date to the Classical era. This study is designed to assess the variance of the eyebrow
      from the desired aesthetic position (as determined by the subject), as wel as to assess the
      distance of normal excursion of the brow from maximum voluntary depression to maximum
      voluntary elevation.
    

Detailed description: 
      A set of 5 digital photographs will be taken of 100 (30 male, 70 female) adult study
      participants. Prior to photography, water soluble ink will be used to mark the inferior
      aspect of the superior orbital rim above the medial and lateral canthi and in the mid
      pupillary line. Photographs taken will image patients from crown to chin and will be taken
      with eyes open and closed, brows raised, maximally contracted and at rest. A final photograph
      will be taken with the subject manually holding both brows in the position he/she finds most
      aesthetically pleasing as seen in a mirror. During all photography, a ruler will be held
      against the face for later calibration, all photographs will be taken with a camera mounted
      flash and with the patient in a Frankfort horizontal plane. All photographs will be analyzed
      with proprietary computer software.
    

Intervention name(s): Eyebrow Position
Intervention type(s): Behavioral
Intervention description(s): Photography of brow positions
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Adults, between the ages of 18- 85
      
Keywords: brow ptosis, facial aesthetics, browlift, facelift
Quality of Life in Managing Chronic Pain
Condition: Chronic Low Back Pain
MeSH terms: Low Back Pain; Chronic Pain
Study type: Interventional

Summary: 
      This study evaluates the use of a health-related quality of life report based on the SPADE
      cluster (sleep disturbance, pain interference with activities, anxiety, depression, and low
      energy/fatigue) derived from the PROMIS-29 instrument in patients with chronic low back pain.
      Half of the participants will receive the report, while the other half will not.
    

Detailed description: 
      The health-related quality of life report provides participants with an overall score on the
      SPADE cluster and scores on each of its five component scales. The recently released Federal
      Pain Research Strategy states that pain cannot be measured in isolation, but rather should be
      assessed in conjunction with other outcome measures in 'non-pain domains,' such as quality of
      life. It recognizes that pain may be affected by, and affect, such patient attributes as
      sleep, mood, cognition, function, and quality of life. Further, the report states that
      improvement in pain without concomitant improvement in other domains may not constitute a
      clinically meaningful outcome. This study aims to assess the utility of a health-related
      quality of life report in improving quality of life, back pain intensity, and back-related
      disability in participants with chronic low back pain.
    

Intervention name(s): Health-Related Quality of Life Report
Intervention type(s): Other
Intervention description(s): Subject report and interpretation guide based on SPADE cluster scores
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Data Acquisition Study for a Communication Device for Pediatric Patients With Cerebral Palsy
Condition: Cerebral Palsy
MeSH terms: Cerebral Palsy
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate a touch screen application designed to help
      pediatric patients with cerebral palsy communicate. The study will test how well patients
      type on two different tools: one tool is already on the market , and the second tool is a
      newly developed App.
    


Intervention name(s): Dynavox Maestro; Experimental App
Intervention type(s): Device; Device
Intervention description(s): Receives commercially available communication device Dynavox Maestro to test speed and quality of communication.; Participant receives experimental app to test speed and error rate of communication.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Generation 100: Blood Volume and Cardiac Function in Healthy Aging
Condition: Ageing
Study type: Interventional

Summary: 
      Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The
      extent of reduction will be intensity dependent.

      As part of the "Generation 100" study, this sub-study project will investigate the effect of
      exercise on blood volume, cardiopulmonary health and heart function in healthy aging.
      Objective is to determine the acute effect of one endurance training session on blood volume
      in healthy elderly. The working hypothesis is that one interval training session increases
      total blood volume by 10% in healthy elderly, and that there will be no change after moderate
      continuous training.
    


Intervention name(s): high intensity interval training; moderate intensity training
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Exercise; Elderly; Blood volume; Hemoglobin
Effects of an Aquatic Therapy Program Versus a Land Program in Patients Who Suffered a Stroke
Condition: Stroke; Hydrotherapy
MeSH terms: Stroke
Study type: Interventional

Summary: 
      The objective of this study is to investigate the relative effectiveness of CCT on water
      versus on land in stroke patients. Additionally, the study will to determine if there are
      differences in the results obtained, between two CCT programs in the following parameters:
      gait, balance and dexterity
    

Detailed description: 
      This study is a randomized controlled trial of the effectiveness of a structured CCT program
      in water versus a structured CCT program on land in the rehabilitation of stroke survivors.
    

Intervention name(s): circuit class therapy in water; circuit class therapy on land
Intervention type(s): Other; Other
Intervention description(s): The circuit, the main part of the session, include a series of 10 different workstations, arranged to progress in complexity, in order to work several segments of the body, oriented towards a functional recovery objective. These stations will be made up of task-specific activities for gait, balance and dexterity. Time in each workstation will be 5 minutes divided as follows: 4 minutes work period and 1 minute rest period, of these, last 30 seconds will be change period for crossing from one workstation to the next. After 50 minutes, each patient will have covered the 10 workstations, thus working in all of the objectives pursued in the realization on this CCT: gait, balance and dexterity.; The circuit, the main part of the session, include a series of 10 different workstations, arranged to progress in complexity, in order to work several segments of the body, oriented towards a functional recovery objective. These stations will be made up of task-specific activities for gait, balance and dexterity. Time in each workstation will be 5 minutes divided as follows: 4 minutes work period and 1 minute rest period, of these, last 30 seconds will be change period for crossing from one workstation to the next. After 50 minutes, each patient will have covered the 10 workstations, thus working in all of the objectives pursued in the realization on this CCT: gait, balance and dexterity.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: circuit class therapy; ICF model; aquatic therapy; neuro-rehabilitation
Internal Plate Fixation vs. Plaster in Complete Articular Distal Radial Fractures
Condition: Displaced Complete Articular Distal Radius Fractures
MeSH terms: Fractures, Bone; Radius Fractures; Wrist Fractures
Study type: Interventional

Summary: 
      There is no consensus about the best treatment for patients with displaced complete articular
      distal radius fractures (AO type C fractures). Despite this lack of consensus and the lack of
      available literature on comparative data to guide treatment for this patient population,
      operative treatment with plate fixation has gained popularity. The aim of this study is to
      compare the functional outcome of open reduction and plate fixation with closed reduction and
      plaster immobilisation in adult patients (18-75 years) with displaced complete articular
      distal radius fractures.
    

Detailed description: 
      Distal radius fractures account for 17% of all fractures diagnosed. Two third of those
      fractures are displaced and need to be reduced.

      According to the Dutch National Guidelines, displaced distal radius fractures, after adequate
      reduction confirmed on X-ray, are best treated nonoperatively with cast immobilization.
      Moreover, the AAOS Clinical Practice Guideline only suggest surgical fixation when the
      articular step, after reduction, exceeds 2mm. However, both recommendations are based on
      studies who did not differentiate between intra- and extra-articular distal radius fractures.
      So, no clear consensus about the best treatment for patients with displaced intra-articular
      distal radius fractures can be made. Despite this lack of consensus and the lack of available
      literature on comparative data to guide treatment for this patient population, a rise in use
      of volar plating has been observed.

      The goal of open reduction and plate fixation is to restore articular congruity and axial
      alignment, and to enable early post-operative movement. Several studies show good
      radiological and functional results using the volar locking plate in unstable displaced
      distal radius fractures.

      No studies have been carried out to assess whether operative treatment with plate fixation is
      superior in displaced complete articular distal radius fractures to nonoperative treatment in
      patients with these fracture type. Therefore, with this randomized controlled trial the
      investigators wish to determine the difference in functional outcome, assessed with the
      Patient Related Wrist Evaluation (PRWE), after open reduction and plate fixation compared to
      nonoperative treatment with closed reduction and cast immobilization.
    

Intervention name(s): Open reduction and internal plate fixation; Closed reduction and plasterimmobilisation
Intervention type(s): Procedure; Other
Other intervention name(s): ORIF; Surgical treatment; Cast; Conservative treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Acupoint Stimulation for Pain Reduction and the Associated Benefits in Head and Neck Cancer Patients Receiving Concurrent Chemoradiotherapy
Condition: Head and Neck Cancer
MeSH terms: Head and Neck Neoplasms
Study type: Interventional

Summary: 
      This study was designed to investigate the effect of Acupoint stimulation on pain reduction,
      and fatigue, anxiety and depression and quality of life in Head neck cancer receiving
      Concurrent Chemoradiotherapy.
    

Detailed description: 
      Data were collected from 92 participants in northern Taiwan medical center Radiation
      Outpatient.They are randomly assigned to the experimental group (n=46) with Acupoint
      stimulation and control group(n=46). Outcomes were assessed according to the pain, Brief
      fatigue inventory, Hospital anxiety and depression scale, quality of life, five repeated
      measures was conducted.
    

Intervention name(s): Device: Transcutaneous acupoint electrical stimulation and seeds for auricular acupressure
Intervention type(s): Other
Intervention description(s): Experimental group received Acupoint stimulation, Transcutaneous acupoint electrical stimulation20 minutes/weeks, once a week for six consecutive weeks.
The second part of The Experimental group received Auricular acupressure applied to four acupoints, including shenmen (TF2), mouth (IC6), subcortex (CW2), Occiput (AT3). each point is 1min, 5days/week, 3 times/day.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Intervention is divided into two parts: part of The Experimental group received Transcutaneous acupoint electrical stimulation 20 minutes/weeks, the acupoints are unilateral Hegu (LI4) and LU7; This study used Transcutaneous nerve electrical stimulation , 20 minutes each time, once a week for six consecutive weeks.
The second part of The Experimental group received Auricular acupressure applied to four acupoints, including shenmen (TF2), mouth (IC6), subcortex (CW2), Occiput (AT3).A seeds embedding method with seeds attached to the four sides of the unilateral ear, using the thumb and forefinger to apply pressure, the participants will feel sour, each point is 1min, 5days/week, 3 times/day.
Control group: without intervention
Masking: None (Open Label)
Primary purpose: Supportive Care
Safety and Pharmacokinetics Evaluation Study According to the Dose of Camostat Mesylate in Healthy Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      Safety and pharmacokinetics evaluation study according to the dose of camostat mesylate in
      healthy volunteers
    


Intervention name(s): DWJ1248
Intervention type(s): Drug
Intervention description(s): Camostat mesylate Tablet from Daewoong
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Part1. Parallel, Part2. Crossover
Masking: None (Open Label)
Primary purpose: Treatment