bioihbjkbjnl/mcl2 huggingface dataset:
Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque
Condition: Carotid Atherosclerosis; Stroke; Type 2 Diabetes; Metabolic Syndrome
MeSH terms: Carotid Artery Diseases; Atherosclerosis; Metabolic Syndrome; Plaque, Atherosclerotic
Study type: Interventional

Summary: 
      The aim of the present study is to examine the atherosclerotic plaque stability using in vivo
      and in vitro techniques and to investigate the influence of exercise, anti-diabetic,
      lipid-lowering and cannabinoids receptor antagonists on atherosclerotic plaque texture in
      patients with cardiovascular risk and animals prone to atherosclerosis.
    


Intervention name(s): atorvastatin; rimonabant; rosiglitazone; metformin
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): A:Experimental study of atherosclerosis B1:Effects of exercise on experimental atherosclerosis B2:Effects of exercise on high risk patients C1:Effects of statins on atherosclerotic plaque stability (experimental) C2:Effects of statins on atherosclerotic plaque stability (clinical) D:Effects of rosiglitazone and metformin on cardiovascular risk factors E:Effects of rimonabant on atherosclerotic plaque stability (experimental); A:Experimental study of atherosclerosis B1:Effects of exercise on experimental atherosclerosis B2:Effects of exercise on high risk patients C1:Effects of statins on atherosclerotic plaque stability (experimental) C2:Effects of statins on atherosclerotic plaque stability (clinical) D:Effects of rosiglitazone and metformin on cardiovascular risk factors E:Effects of rimonabant on atherosclerotic plaque stability (experimental); A:Experimental study of atherosclerosis B1:Effects of exercise on experimental atherosclerosis B2:Effects of exercise on high risk patients C1:Effects of statins on atherosclerotic plaque stability (experimental) C2:Effects of statins on atherosclerotic plaque stability (clinical) D:Effects of rosiglitazone and metformin on cardiovascular risk factors E:Effects of rimonabant on atherosclerotic plaque stability (experimental); A:Experimental study of atherosclerosis B1:Effects of exercise on experimental atherosclerosis B2:Effects of exercise on high risk patients C1:Effects of statins on atherosclerotic plaque stability (experimental) C2:Effects of statins on atherosclerotic plaque stability (clinical) D:Effects of rosiglitazone and metformin on cardiovascular risk factors E:Effects of rimonabant on atherosclerotic plaque stability (experimental)
Intervention MeSH terms: Metformin; Rosiglitazone; Rimonabant; Atorvastatin
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Keywords: cardiovascular events
Mifepristone for Labor Induction
Condition: Induced Vaginal Delivery
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this trial is to explore mifepristone as an option for induction of labor at
      term by evaluating the efficacy of mifepristone use for cervical preparation. Since the Labor
      Induction versus Expectant Management in Low-Risk Nulliparous Women (ARRIVE) trial supporting
      that elective induction after 39 weeks decreases cesarean sections and morbidity, rates of
      elective term inductions are increasing.

      At Lucile Packard Children's Hospital at Stanford University specifically, approximately 40%
      of spontaneous vaginal deliveries follow induction of labor, with an average induction time
      of 20 hours. Previous studies have established the maternal and neonatal safety of
      mifepristone in term inductions, however, this study will assess the difference in overall
      time from induction to complete cervical dilation, delivery, and the total time on Labor and
      Delivery.
    


Intervention name(s): Mifepristone; Misoprostol
Intervention type(s): Drug; Drug
Intervention description(s): Mifepristone 200mg taken orally; Misoprostol 50 mcg taken orally, and may receive additional doses of misoprostol 50 - 100 mcg as needed
Intervention MeSH terms: Misoprostol; Mifepristone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Study to Evaluate the Photoirritation Potential of PEP005 (Ingenol Mebutate) Gel, 0.01% in Healthy Volunteers
Condition: Actinic Keratosis
MeSH terms: Keratosis, Actinic; Keratosis
Study type: Interventional
Phase: Phase 1

Summary: 
      This Phase 1 study is designed to determine the photoirritation potential of PEP005 Gel,
      0.01% when application is followed by light exposure.
    


Intervention name(s): PEP005 (ingenol mebutate) Gel
Intervention type(s): Drug
Intervention description(s): PEP005 (ingenol mebutate) Gel, 0.01%
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Peplin; PEP005
Timing of Delivery in Fetal Growth Restriction of Uncomplicated Women
Condition: Fetal Growth Restriction
MeSH terms: Fetal Growth Retardation
Study type: Interventional

Summary: 
      The goal of the study is to determine whether labor induction at 37 weeks of pregnancy can
      improve the baby's health at birth when compared with delivery at a later point in the
      pregnancy.
    


Intervention name(s): Labor induction at 37.0 to 37.6 weeks of gestation; Expectant monitoring until delivery
Intervention type(s): Procedure; Procedure
Intervention description(s): Diagnosis of FGR with induction at 37 weeks 0 days of gestation to 37 weeks and 6 days; Diagnosis of FGR managed with expectant monitoring and delivery as indicated
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate in Patients With Moderate Hepatic Impairment Compared to Subjects With Normal Hepatic Function
Condition: Hepatic Insufficiency
MeSH terms: Hepatic Insufficiency; Liver Failure
Study type: Interventional
Phase: Phase 1

Summary: 
      Assessment of the effect of moderate liver impairment (Child-Pugh classification B) on the
      pharmacokinetics and pharmacodynamics of dabigatran after oral administration of dabigatran
      etexilate. Determination of safety and tolerability of dabigatran upon administration to
      hepatically impaired patients and healthy subjects (matched pairs)
    


Intervention name(s): Dabigatran etexilate
Intervention type(s): Drug
Intervention MeSH terms: Dabigatran
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Validation Study of Oral Teleconsultation
Condition: Dental Care
Study type: Observational

Summary: 
      In this study we want to evaluate the oral care pathway after an oral teleconsultation.
    

Detailed description: 
      An oral teleconsultation was proposed to the 461 residents of the public hospital of Uzès. A
      specifically trained nurse recorded 4 videos (1 per quadrant) per mouth with an intra-oral
      camera using fluorescent light (Soprocare®) and keyed in information about the resident
      (general state, identification,…). These data were recorded and sent onto a central secured
      server, through a specific piece of software (e-DENT®). The dentists from the University
      Hospital of Montpellier were then able to analyse the videos remotely, make a diagnosis and
      organise each resident's oral care.
    

Intervention name(s): teleconsultation
Intervention type(s): Other
Intervention description(s): Patients performing oral care required as a result of their diagnosis by teleconsultation in vulnerable populations (elderly, disabled adults).
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        People who are in long-term care home with oral telemedicine activity
Lipiodol Localization for Ground-glass-opacity Minimal Surgery
Condition: Pulmonary Lesion With Ground-glass-opacity
Study type: Interventional

Summary: 
      The study object is to demonstrate the usefulness and safety of lipiodol localization
      technique for individuals undergoing ground-glass opacity (GGO) Video-assisted thoracic
      surgery (VATS) resection compared to hook wire localization technique. A total of 250
      participants will be enrolled in a 1:1 fashion to Lipiodol or Hook-wire groups. If the aims
      of this study are achieved, the use of lipiodol localization technique will be widespread
      their application for localization of non-palpable pulmonary lesions that are indicated for
      VATS resection.
    


Intervention name(s): Lipiodol; Hookwire; Lipiodol
Intervention type(s): Procedure; Procedure; Drug
Intervention description(s): Lipiodol-guided lung localization technique; Hookwire-guided lung localization technique
Intervention MeSH terms: Ethiodized Oil
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Ground-glass-opacity (GGO); Lung localization; Lipiodol; Hook wire; Video assisted thoracic surgery (VATS)
Safety, Tolerability, and Immunogenicity of VAL-339851 in Healthy Adult Subjects
Condition: Influenza
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 1

Summary: 
      This clinical study will assess the safety, tolerability and immunogenicity of VAL-339851 in
      healthy subjects.
    


Intervention name(s): VAL-339851; Placebo
Intervention type(s): Biological; Other
Intervention description(s): Escalating dose levels; Saline
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Prevention
Keywords: VAL-339851; H7N9 antigen mRNA; Influenza vaccine; Moderna
Intraarticular Injections of Platelet-rich Plasma in Pain's Treatment of the Osteoarthritic Knee
Condition: Knee Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional
Phase: Phase 3

Summary: 
      Platelet-rich plasma (PRP), due to its high content of cytokines, bioactive proteins and
      platelet growth factors, may contribute to diminish the pain of arthritic knee. It was also
      recently recognized a regenerative cell potential improving the concentration of hyaluronic
      acid and stabilizing angiogenesis in arthritic knees

      This study therefore seeks to assess the analgesic power of PRP in osteoarthritic knees
      intraarticularly infiltrated, and which patients would benefit most from treatment,
      eliminating false expectations in the rest.
    

Detailed description: 
      This is the first clinical trial developed following the report of the Spanish Competent
      Authority on May 23, 2013, considering the PRP as a medicinal product for human use and
      establishing minimum guarantees required of the product and the process of manufacturing. It
      has been conducted from the perspective of both the trauma and the specialized treatment of
      chronic pain anesthesiologist, and manufacturing the PRP on the premises of a Regional Centre
      for Transfusions, all belonging to the Public Health System and therefore without commercial
      interests.
    

Intervention name(s): Platelet rich plasma; Hyaluronic acid
Intervention type(s): Biological; Drug
Intervention description(s): Three intraarticular injections of platelet-rich plasma, one each fifteen days; Infiltrations of Hyaluronic acid as Hyaluronate 2,5 ml, 1% solution, administered by intraarticular injections (three doses, one each fifteen days)
Other intervention name(s): PRP, Platelet Concentrate; Adant
Intervention MeSH terms: Hyaluronic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Knee osteoarthritis; Platelet-rich plasma; Pain's treatment
Study to Compare the Efficacy and Safety Between Levocetirizine and Loratadine for Chronic Idiopathic Urticaria
Condition: Urticaria
MeSH terms: Urticaria; Chronic Urticaria
Study type: Interventional
Phase: Phase 3

Summary: 
      Study to Compare the Efficacy and Safety Between Levocetirizine and Loratadine for Chronic
      Idiopathic Urticaria.
    


Intervention name(s): levocetirizine dihydrochloride
Intervention type(s): Drug
Intervention MeSH terms: Levocetirizine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single
Primary purpose: Treatment
Keywords: Levocetirizine dihydrochloride; Xyzal tablets
Evaluation of the Patient Experience With a Surgically-assisted Acceleration Method of Orthodontic Treatment
Condition: Crowding, Tooth
MeSH terms: Malocclusion
Study type: Interventional

Summary: 
      The duration of orthodontic treatment is one of the exacerbation causes of orthodontic pain.
      Several methods have been suggested to reduce the duration of orthodontic treatment
      classified to surgical and non-surgical methods.

      Researches used minimally invasive surgical methods like corticision, piezocesion, disicion,
      micro-osteoperforation, and piezopuncture indicated that most of these methods can accelerate
      dental movement by 20 - 40% without causing additional pain as a result of using those
      methods.

      Applying corticision on the lower anterior teeth using a surgical blade and a hammer may
      accelerate tooth alignment during orthodontic treatment. This study consists of two groups,
      patients will be randomly assigned to one of these two groups.
    

Detailed description: 
      Pain is defined as an unpleasant emotional sensory experience associated with actual or
      potential harm. It was mentioned as one of the most common complaints related to orthodontic
      treatment, and around 65-95% of patients undergoing orthodontic treatment suffer from various
      degrees of pain.

      Corticision is one of the minimally invasive surgical procedures that is not associated with
      flap lifting. It was used to accelerate tooth movement in animals and case report studies.
      Its application on humans may aggravate their fear and anxiety towards the pain that may
      accompany this technique.

      No study in the literature has been searched in patient perception of pain, discomfort,
      levels of acceptance and satisfaction accompanied corticision application application, but in
      this study, these previous variables accompanied corticision technique have been studied on
      crowded lower anterior teeth cases which are one of the most common types of malocclusions.
    

Intervention name(s): Corticision; Conventional fixed appliance
Intervention type(s): Procedure; Device
Intervention description(s): Corticision will be performed to enhance teeth alignment.; No surgical intervention is going to be applied to the patients in this group.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Corticision; Visual analog scale; Mild and moderate crowding; Surgical blade; Pain; Discomfort
Anterolateral Watson Jones Approach Versus Transgluteal Approach for Uncemented Hemi- Arthroplasty in Displaced Femoral Neck Fracture
Condition: Femoral Neck Fracture
MeSH terms: Fractures, Bone; Femoral Neck Fractures
Study type: Interventional

Summary: 
      Hemiarthroplasty is a well established treatment of Femoral Neck Fractures in the Elderly.
      During the last decade the use of Minimal Invasive Surgical( MIS) approaches have been
      increasing. Our hypothesis is that Patients with a Femoral Neck Fracture may benefit from a
      MIS approach.
    

Detailed description: 
      The study's main objective: The purpose of the study is to test the following hypothesis.
      Patients 70 to 90 years with a displaced femoral neck fracture, operated with a
      hemiarthroplasty through an anterolateral approach, have less pain and better patient
      satisfaction as measured by PROMs than patients operated through the lateral approach.

      The study's subsidiary objectives. We aim to shed light on the following subsidiary
      hypotheses.

        1. A hemiarthroplasty inserted through an anterolateral approach gives less bone
           resorption, as measured by DEXA around the stem, than a hemiarthroplasty inserted via a
           direct lateral approach.

        2. A hemiarthroplasty inserted through an anterolateral approach causes lesser degree of
           muscle damage, as measured by CK, than a direct lateral approach
    

Intervention name(s): hemiarthroplasty
Intervention type(s): Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Femoral Neck Fracture; Anterolateral approach; Trans-gluteal approach; Watson Jones approach; Hardinge approach
Observation of the Gait Cycle in Patients With Hemiplegia in Order to Improve the Triggering of Functional Electrical Stimulation
Condition: Stroke
MeSH terms: Hemiplegia
Study type: Observational

Summary: 
      The main objective of this study is the estimation and comparison of the dephasing between
      the switch heel and the inertial placed on the paretic foot compared to the events of the
      gait cycle determined by a Gaitrite system (beginning and end of the swing phase) in
      conditions without stimulation.
    


Intervention name(s): Gait analysis
Intervention type(s): Other
Intervention description(s): A Gaitrite system, a goniometer, and EMG are used to record data while the patient walks 10 meters.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Study patients are recuted from the patient pool that is either hospitalized or consulting
        in the department of Neurological Reeducation and Readaptation at the Grau du Roi medical
        center at the Nîmes University Hospital (Centre Hospitalier Universitaire de Nîmes).
        Patients are stroke victims with gait problems.
Influence of Myocardial Shortening on Coronary Tortuosity
Condition: Coronary Artery Vessels; Coronary Artery Disease
MeSH terms: Coronary Artery Disease
Study type: Observational

Summary: 
      This study is a retrospective analysis where coronary arteriograms are being analyzed to
      determine whether the presence of tortuous coronary arteries correlate with any specific
      measures of left ventricular mass or left ventricular function on echocardiography.
    


Intervention name(s): No intervention. Observational study
Intervention type(s): Other
Intervention description(s): No intervention
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Retrospective study of subjects who have undergone clinically-indicated coronary
        arteriography who also have an echocardiogram that was performed within 3 months of the
        angiogram.
Treatment of Early Onset Schizophrenia Spectrum Disorders (TEOSS)
Condition: Schizophrenia
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 4

Summary: 
      This study will evaluate the safety and efficacy of risperidone (Risperdal®), olanzapine
      (Zyprexa®), and molindone (Moban®) for the treatment of children and adolescents with
      schizophrenia or schizoaffective disorder.
    

Detailed description: 
      Little research has been conducted on the use of psychotropic agents in children and
      adolescents with early onset schizophrenia spectrum disorders. This study will compare
      antipsychotic agents with different mechanisms of action in children and adolescents who have
      schizophrenia or schizoaffective disorder with active psychotic symptoms.

      Participants are randomly assigned to receive risperidone (Risperdal), olanzapine (Zyprexa),
      or molindone (Moban) for 8 weeks. After 11/2005, no additional patients will be assigned to
      olanzapine treatment. Patients with significant improvement and without side effects continue
      maintenance therapy for another 44 weeks. Participants who show significant negative symptoms
      after 8 weeks may be started on a mood stabilizer or antidepressant. Weight gain, metabolic
      changes, neurocognition, functional outcome, psychotic symptoms, extrapyramidal side effects,
      and the ability to sustain effective therapy over time are assessed.
    

Intervention name(s): Risperidone; Olanzapine (enrollment closed in this treatment); Molindone
Intervention type(s): Drug; Drug; Drug
Intervention description(s): oral risperidone 0.5mg to 6mg daily for up to 52 weeks; oral olanzapine 5-20mg per day for up to 52 weeks; oral molindone from 10-140mg/daily for up to 52 weeks
Other intervention name(s): Risperdal; Zyprexa; Moban
Intervention MeSH terms: Olanzapine; Risperidone; Molindone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Psychotic Disorders; Schizophreniform Disorder
A Study to Evaluate Molnupiravir (MK-4482) in Participants With Moderate Hepatic Impairment (MK-4482-016)
Condition: Hepatic Impairment
MeSH terms: Liver Diseases
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the pharmacokinetics (PK) of N-hydroxycytidine (NHC)
      following a single oral dose of molnupiravir in participants 18 to 75 years (inclusive) with
      moderate hepatic impairment and healthy matched controls.
    


Intervention name(s): Molnupiravir
Intervention type(s): Drug
Intervention description(s): Four 200 mg capsules administered orally as a single dose
Other intervention name(s): MK-4482,; MOV; EIDD-2801
Intervention MeSH terms: Molnupiravir
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Silent Cerebrovascular Lesion and Cognitive Decline Prevention by Cholesterol Lowering in Elderly AF Patients
Condition: Atrial Fibrillation; Neuropsychology; Magnetic Resonance Imaging; Inflammation; Hemostasis
MeSH terms: Atrial Fibrillation; Inflammation; Cognitive Dysfunction
Study type: Interventional
Phase: Phase 4

Summary: 
      In elderly patients with atrial fibrillation (AF) the presence of silent brain infarcts and
      neurocognitive deficit is high despite adequate treatment with oral anticoagulation.
      Atherosclerosis is considered to be a chronic inflammatory disease and thrombosis and
      inflammation are strongly correlated. Atrial fibrillation is linked with increased levels of
      inflammatory markers and intensive cholesterol lowering has proven to reduce inflammation. In
      a prospective double-blind randomized pilot-study we want to test the hypothesis, that
      addition of intensive cholesterol lowering treatment besides adequate oral anticoagulation
      will reduce cerebrovascular lesions and will be beneficial for neurocognitive status in
      elderly AF patients.
    


Intervention name(s): Atorvastatin; ezetimibe
Intervention type(s): Drug; Drug
Intervention MeSH terms: Atorvastatin; Ezetimibe
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Prevention
Keywords: Atrial Fibrillation; elderly; cholesterol lowering; neurocognitive function; cerebrovascular lesion