bioihbjkbjnl/mcl2 huggingface dataset:
Broccoli Ileo Study
Condition: Ileostomy - Stoma
Study type: Interventional

Summary: 
      Epidemiological and experimental studies have indicated that the consumption of diets rich in
      cruciferous vegetables such as broccoli has a range of beneficial effects on human health.
      These effects are usually attributed to naturally-occurring glucosinolates and their
      breakdown products, isothiocyanates, in cruciferous vegetables. One of these compounds,
      sulforaphane, the hydrolysis product of glucoraphanin, the main glucosinolate in broccoli has
      been reported to have bactericidal activity against H. pylori and other human pathogens. The
      investigators have recently shown that adding mustard seeds, which contain a more resilient
      form of this enzyme, to processed broccoli actually increased the formation of sulforaphane
      and minimised production of another biologically-inactive form. Experimental studies by the
      investigators have shown that sulforaphane can inhibit growth of a number of enteric
      pathogens including salmonella and E. coli which exert their effects in the small intestine.
      Currently the bioavailability, stability and bioactivity of sulforaphane in the small
      intestine of a human following consumption of broccoli is not known.

      To assess the effect of broccoli phytochemicals in vivo 20 participants who have previously
      had an ileostomy (removal of colon, > 1.5 years post operative) will be fed 200 ml of
      broccoli soup/control in a randomised double blind crossover design and collect the ileal
      fluid before (0 hr) and after (4 hr) the feeding. The ileal fluid collected from participants
      will have undergone in vivo digestion, allowing analysis of the chemical composition and
      bioactivity of the ileal fluid. The hypothesis to be tested is that consumption of cooked
      broccoli plus myrosinase from mustard seeds will result in high levels of sulforaphane in
      ileostomy fluid, sufficient to suppress growth of enteric pathogens. This study will be used
      to assess whether previous observations on the in vitro antibacterial activity of broccoli
      are relevant in vivo.
    


Intervention name(s): Broccoli & mustard seed soup; Broccoli soup
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 200ml acute feed; 200ml acute feed
Intervention MeSH terms: Mechlorethamine
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Randomised double blind crossover design.
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Keywords: Broccoli; Bioavailability; Ileostomists; Randomised controlled trial; Phytochemical
Skin Ulcers Treatment With an Handicraft Topical Device
Condition: Foot Ulcer; Varicose Ulcer
MeSH terms: Varicose Ulcer; Foot Ulcer; Skin Ulcer; Ulcer
Study type: Interventional
Phase: Phase 4

Summary: 
      The aim of this study was to evaluate the efficacy of a handicraft topical device of negative
      pressure versus traditional healing treatment for skin ulcers in lower limbs; in patients
      with diabetes mellitus, venous stasis and arterial insufficiency.
    

Detailed description: 
      The hypothesis of this trial is that the handicraft topical device of negative pressure is
      even better for the treatment of skin ulcers located in the lower limbs of patients with
      diabetes mellitus, venous stasis and arterial insufficiency. We anticipate that in a sample
      of 144 patients with ulcer, will heal or at least improve with this treatment
    

Intervention name(s): drenovac handcrafted; Healing
Intervention type(s): Procedure; Procedure
Intervention description(s): under local anesthesia, sepsis and antisepsis, place sterile field, prepared area go out all devitalized or necrotic tissue using liquid soap surgical and irrigation back saline 0.9%. We introduce a device to distribute the negative pressure or vacuum on ulcer; conducted margins make recommendations 5-12 mm over the edge of the wound, applying negative pressure or vacuum retracted sponges, likewise for the spare fewer gauze was placed Sterile adhesive film covering the defect to seal the system cover adequately the probe output nelaton not to submit drain the system. Connect the probe to the sterile nelaton this hose and a suction system with pressure gauge, pressure -80-125 mmHg. Change it every 72 hours.; Were handled as follows:
Under local anesthesia, prior asepsis and antisepsis of the skin ulcer with iodinepovidone sterile fields are placed, we proceeded to debridement of all necrotic tissue or devitalized then a cure with liquid soap surgery was performed and was irrigated with 1000 cc of solution physiological 0.9%, and finally the ulcer was covered with sterile gauze.
healing of skin ulcers were performed every 24 hours.
the evolution of skin ulcers was evaluated every 3 days, requesting a differential valuing of clinical and biochemical form the aforementioned variables.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: Diabetic foot ulcer; Foot care; Wound management
The Need of Fiberoptic Bronchoscopy for Placing an Endobronchial Blocker
Condition: Neoplasms, Pulmonary; Thoracic Diseases
MeSH terms: Lung Neoplasms; Thoracic Diseases
Study type: Interventional

Summary: 
      The need of fiberoptic bronchoscopy for placing an endobronchial blocker. Endobronchial
      blockers (EBB) have been presented effective and safe alternative for lung separation in
      vedio-assisted thoracoscopic (VATS) operations. In this study, the investigators will
      randomize the patients receiving VATS operation with EBB into two groups: one group will
      receive the conventional bronchoscopic guided EBBs placement, the other group receive two
      step procedure without confirmation by fiberoptic bronchoscopy.
    

Detailed description: 
      The need of fiberoptic bronchoscopy for placing an endobronchial blocker. Endobronchial
      blockers (EBB) have been presented effective and safe alternative for lung separation in
      vedio-assisted thoracoscopic (VATS) operations. However, there were previous reports showed
      that it takes longer time to position the EBB versus the double lumen tubes. Placing EBBs
      need three-step procedure (one is placing an endotracheal tube, the second is inserting the
      EBB, the third is confirmation of the position by fiberoptic bronchoscopy). In this study,
      the investigators will randomize the patients receiving VATS operation with EBB into two
      groups: one group will receive the conventional 3-step procedure, the other group receive two
      step procedure without confirmation by fiberoptic bronchoscopy.
    

Intervention name(s): conventional; auscultation
Intervention type(s): Procedure; Procedure
Intervention description(s): insertion endobronchial blocker with the guidance of fiberoptic bronchoscopy; insertion endobronchial blocker by auscultation, without the guidance of fiberoptic bronchoscopy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Keywords: endobronchial blocker; lung separation; vedio-assisted thoracic operation
20-Week Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia
Condition: Anemia; Chronic Kidney Disease
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic; Anemia
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate the hemoglobin response (efficacy), safety, and
      tolerability of orally administered AKB-6548 in participants with Chronic Kidney Disease
      (pre-dialysis) with anemia with dosing for 20 weeks.
    


Intervention name(s): AKB-6548; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Oral dose administered once daily for 20 weeks. Dose adjustment based on hemoglobin level as defined in the protocol.; Oral Placebo administered once daily for 20 weeks. Dose adjustment based on hemoglobin level as defined in the protocol.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: anemia; chronic kidney disease; CKD; chronic renal insufficiency; renal impairment; erythropoietin; kidney; oral anemia treatment; hemoglobin; hypoxia-inducible factor; HIF; hypoxia-inducible factor prolyl-hydroxylase inhibitor; HIF-PHI; efficacy; safety; pharmacokinetics
Colorectal Cancer Screening With Improved Shared Decision Making
Condition: Colorectal Cancer Screening; Shared Decision Making
MeSH terms: Colorectal Neoplasms
Study type: Interventional

Summary: 
      The purpose of this study is to increase colorectal cancer screening by implementing a
      community-wide shared decision-making (SDM) intervention, which embeds shared decision making
      within clinical practice and also uses an extensive community engagement campaign. The
      investigators hypothesize that colorectal cancer screening adherence will be higher in the
      intervention group (participating communities) compared to the usual care control group
      (non-participating comparison communities).
    

Detailed description: 
      Clinical practice: All patients 50-75 years seen in the participating primary care clinics
      during the study period who are non-adherent to CRCS recommendation. This sample is
      anticipated to be N~50,000 patients.

      Community engagement: Includes mailed questionnaires to age-eligible adults residing in
      intervention and comparison (control) communities (N=2150).
    

Intervention name(s): Shared Decision Making for Colorectal Cancer Screening
Intervention type(s): Behavioral
Intervention description(s): Age-eligible adults in the intervention communities will be exposed to the shared decision-making intervention when they are seen in the primary care clinics (N=all patients 50-75 years seen during the study period who are non-adherent to CRCS recommendation). Additionally, among patients with primary care visits scheduled one week or more before the visit, they will be randomized to receive either a mailed decision aid booklet or an informational flyer on shared decision making and CRCS prior to the visit. Patients with primary care visits scheduled less than one week prior to the visit will not be mailed materials in advance. The effect of the pre-visit materials on referral to SDM session and CRCS adherence between these groups will be compared. They will also be exposed to shared decision-making tools and resources available through the community-wide intervention activities.
Other intervention name(s): CRCS-WISDM
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Shared decision making; Ambulatory Care; Patient-Centered Care; Community-wide intervention; Intervention Study; Longitudinal Studies
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics Pharmacodynamics of SHR-2010 by Intravenously/Subcutaneously in Healthy Subject
Condition: IgA Nephropathy
MeSH terms: Glomerulonephritis, IGA
Study type: Interventional
Phase: Phase 1

Summary: 
      The study is being conducted to Evaluate the Safety, Tolerability and Pharmacokinetics
      pharmacodynamics of SHR-2010 by intravenously/subcutaneously in Healthy Subject.
    


Intervention name(s): SHR-2010 injection; SHR-2010 injection placebo
Intervention type(s): Drug; Drug
Intervention description(s): Treatment for intravenously: 6 subjects for SR-2010 injection. Treatment for subcutaneously: 8 subjects for SR-2010 injection.; Treatment for intravenously: 2 subjects for placebo. Treatment for subcutaneously: 2 subjects for placebo.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: SHR-2010 injection compared with placebo
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Effect of Different Pre-seasonal BM32 Dosings on the Induction of a Protective Immune Response
Condition: Hypersensitivity
MeSH terms: Hypersensitivity
Study type: Interventional
Phase: Phase 2

Summary: 
      BM32 is a product for immunotherapy of grass pollen allergies. It consists of 4 different
      recombinant proteins (BM321, BM322, BM325 and BM326) adsorbed on alhydrogel. This
      prospective, double-blind. placebo controlled, mono-centric trial investigates the levels of
      allergen specific IgG antibodies following 3, 4 or 5 subcutaneous injections before the grass
      pollen season.
    

Detailed description: 
      The aim of this study is to further optimize the immunization schedule by

        -  moving the last injection into beginning of the grass pollen season for all study arms
           in order to ensure highest possible IgG4 levels when they are needed - i.e. at the peak
           of the grass pollen season,

        -  administration of more than 3 pre-seasonal injections in order to build up sufficiently
           high levels of IgG4 already in the first year of treatment , and

        -  dosing during the beginning of the grass pollen season to establish safety in this
           setting The effect of such optimized immunization schedule on the induction of an IgG4
           immune response as a surrogate parameter for efficacy will be studied. The Total Nasal
           Symptom Score (TNSS) before and after the treatment and Combined Symptom-Medication
           Score (SMS) during the grass pollen season will be evaluated as secondary endpoints.
           This will allow intra-individual comparison of seasonal symptom data and responsiveness
           in the chamber setting.
    

Intervention name(s): BM32; Placebo
Intervention type(s): Biological; Biological
Intervention description(s): BM32 is a mixture of 4 different recombinant proteins directed at the major grass pollen allergens, adsorbed on aluminum hydroxide; Placebo contains aluminum hydroxide only
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Grass pollen allergy; subcutaneous immunotherapy; allergy vaccine; dose regimen
Intra-articular Pulsed Radiofrequency With Steroids Injection Versus Intra-articular Steroids Injection in Chronic Sacroiliac Joint Arthritis
Condition: Pain Management
MeSH terms: Sacroiliitis
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      The sacroiliac joint is Located between the pelvis and base of the spine, the sacroiliac
      joints are strong, stable joints that allow for little movement. While these joints do not
      bend like a knuckle or knee, they are susceptible to degenerative arthritis. Sacroiliac joint
      pain is one of the most common causes of chronic low back pain, accounting for 10% to 27% of
      patients with chronic lower back pain. It is known to be caused by abnormal motion in this
      joint, namely, too much motion or too little motion. Patients with pain experience various
      degrees of pain in the low back, groin, buttock, or posterior thigh.
    

Detailed description: 
      The pain starts when the Sacroiliac joint gets inflamed. There are several reasons it could
      happen. It could be hurt when playing sports or if fall down.

      Sometimes start hurting when the ligaments that hold the SI joint together are damaged, which
      may make the joint move abnormally. The pain associated with sacroiliitis most commonly
      occurs in the buttocks and lower back. It can also affect the legs, groin and even the feet.
    

Intervention name(s): intraarticular radiofrequency + intraarticular methylprednisolone; intraarticular methylprednisolone
Intervention type(s): Drug; Drug
Intervention description(s): intraarticular radiofrequency + intraarticular methylprednisolone (30 mg); intraarticular methylprednisolone (30 mg)
Intervention MeSH terms: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: chronic sacroilitis,radiofrequancy,intraarticular steroids injection
Evaluation of an Antidepressant Pharmacogenomic Algorithm in an Outpatient Clinical Setting
Condition: Depression
MeSH terms: Depression
Study type: Interventional

Summary: 
      This was a study of a genotyping tool that reported on how subjects responded to medications
      and could be used in a community psychiatry practice to improve medication choice for
      depression. After the DNA test, an interpretive report was provided to the subjects'
      physicians. The hypothesis of this pilot study was that it was feasible to use this
      pharmacogenomic algorithm in a new setting to treat depressed subjects..
    

Detailed description: 
      Antidepressant medications are among the most widely prescribed medications. However, only
      35% to 45% of depressed patients have a complete remission of their illness when initially
      treated with these medications. Consequently, the Mayo Clinic psychiatric pharmacogenomic
      team developed a pharmacogenomic algorithm designed to improve the effectiveness and safety
      of antidepressant medications by providing guidance in medication selection and appropriate
      dosing. This algorithm has been incorporated into a new genotyping interpretative report. The
      pharmacogenomic algorithm is based on genotyping both copies of four informative genes. These
      four genes are: 1) the Cytochrome (P450 2D6) gene; 2) the Cytochrome (P450 2C19) gene; 3) the
      Serotonin Transporter gene (SLC6A4); and 4) the Serotonin 2A receptor gene (5HTR2A). The
      trial took place at the Franciscan Skemp Healthcare System in La Crosse, Wisconsin over the
      course of 12 months.
    

Intervention name(s): Pharmacogenomic algorithm
Intervention type(s): Other
Intervention description(s): Genetic test results for 4 genes were put through algorithm and provided to physician for guidance prescribing medication.
Other intervention name(s): GeneSight
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Algorithm; Depression; Assurex; GeneSight
Efficacy of Pre-intubation Chlorhexidine Oral Care on Health Outcomes
Condition: Intratracheal Intubation; Surgery; Anesthesia
Study type: Interventional

Summary: 
      This single-centre, single-blind, randomised controlled study with parallel-group design was
      conducted in Yun Ling, Taiwan between May 2019 and August 2019. Participants were randomly
      allocated to an intervention (mouth care using 0.12% CHX before intubation) or control
      (standard care) group on a 1:1 basis. This study was approved by the institutional review
      board of National Taiwan University Hospital, Taiwan (IRB No.201806086RINB). Each participant
      completed written informed consent after explanation of this study and advised that they
      could withdraw anytime.
    

Detailed description: 
      Participants were recruited at the operation room of a teaching hospital. Participants were
      included if they met the following criteria: 18-80 years of age, American Society of
      Anesthesiologists, ASA) class 1-3, scheduled for surgery under endotracheal tube intubation
      general anesthesia. Patients were excluded if they were diagnosed with upper or lower
      respiratory tract disease, including COPD, cold, had oral ulcer, scheduled to have a
      respiratory-related surgical procedure, had endotracheal tube intubated.
    

Intervention name(s): Oral care
Intervention type(s): Other
Intervention description(s): oral care using 20mL of 0.12% CHX and gargling with 30 seconds.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: oral care; Anesthesia; surgery; Intratracheal Intubation
Virtual Reality for Post Operative Pain
Condition: Pain, Postoperative
MeSH terms: Pain, Postoperative
Study type: Interventional
Phase: Phase 2

Summary: 
      Randomized controlled trial to measure pain experience, side effects and satisfaction of VR
      following varicose vein, hernia repair and gallbladder surgeries.
    

Detailed description: 
      While there is substantial evidence supporting the use of Virtual Reality (VR) during
      dressing changes for burn victims, there are little information of the effect of VR to
      decrease pain after surgery. Although pharmacological analgesics are popular in clinical
      practice, this approach usually is associated with side effects, most commonly nausea,
      cognitive dysfunction, and constipation. Generally, VR effects are based on gate theory of
      cognitive load, due to the fact that conscious attention is needed to perceive pain and we
      can process a finite amount of information.High-Tech-VR devices shown to be more effective in
      reducing pain than are Low-Tech-VR systems (Prothero, J. D., & Hoffman, H. D, 1995). In
      addition, studies have shown that interactivity play an important role to decrease both, pain
      unpleasantness and time spent thinking about pain, while increasing fun (Wender, R., et al.,
      2010, Gromala, D., et al 2011). Thus, interactivity helps patients to have a better immersion
      into VR world. Considering this, in the proposed study, patients will be randomized to either
      receive a high immersive and interactive VR environment using Oculus Rift Headset in addition
      to standard care or to receive only standard care during their post-operative care following
      surgery to prospectively assess the utility of virtual reality (VR) for pain management
      following varicose vein, hernia repair and gallbladder surgeries.
    

Intervention name(s): Virtual Reality intervention - Oculus Rift HD
Intervention type(s): Device
Intervention description(s): During the VR experience patients will have the opportunity to choose from different VR environments (VR application - Nature Treks VR) and explore them using Oculus Rift Device.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: We tested the efficacy of a VR environment in the treatment of pain after surgery.
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment