Ultrasound-guided Lung Recruitment Maneuvers for Postoperative Pediatric Atelectasis
Condition: Atelectasis; Postoperative Complications; Recruitment; Pediatric; Abdominal Surgery
MeSH terms: Pulmonary Atelectasis; Postoperative Complications
Study type: Interventional

Summary: 
      In anesthetized children, the incidence of lung collapse with episodes of hypoxemia is high.
      Diaphragmatic dysfunction induced by general anesthesia is one of the most important factors
      in the genesis of regional losses of lung aeration. The mass of the abdominal organs pushes
      the diaphragm cranially compressing the lungs in the most dependent areas. Such regional lung
      collapse may range from a slight loss of aeration to complete atelectasis.
    

Detailed description: 
      A wide variety of recruitment maneuvers has been described. The most relevant are represented
      by sustained inflation maneuvers, high pressure-controlled ventilation, incremental PEEP, and
      intermittent sighs. However, the best recruitment maneuver technique is currently unknown and
      may vary according to the specific circumstances. The most commonly used recruitment maneuver
      is the sustained inflation technique, in which a continuous pressure of 40 cm H2O is applied
      to the airways for up to 60 seconds. Sustained inflation has been shown to be effective in
      reducing lung atelectasis, improving oxygenation and respiratory mechanics, and preventing
      endotracheal suctioning-induced alveolar derecruitment. However, the efficacy of sustained
      inflation has been questioned and other studies showed that this intervention may be
      ineffective, short-lived, or associated with circulatory impairment, an increased risk of
      baro/volutrauma, a reduced net alveolar fluid clearance, or even worsened oxygenation.

      Lung ultrasound has been gaining consensus as a noninvasive, radiation-free tool for
      diagnosing various pulmonary diseases in adult and pediatric patients. Evidence supporting
      lung ultrasound use is expanding beyond emergency and critical care settings to perioperative
      care.

      It has been reported that lung ultrasound (LUS) at a patient's bedside immediately following
      surgery can be useful for diagnosing respiratory complications. LUS has been proven to be a
      valuable bedside diagnostic tool for pneumothorax, with high sensitivity and specificity
      (78.6% and 98.4%, respectively), and a higher rate of detecting abnormalities such as lung
      alveolar consolidation and pleural effusion than bedside chest X-ray or physical examination.
      LUS has also been used to diagnose anesthesia-induced atelectasis in pediatric patients.
    

Intervention name(s): conventional recruitment maneuvers; ultrasound-guided recruitment maneuvers
Intervention type(s): Procedure; Procedure
Intervention description(s): The recruitment maneuver will be performed at 3 predefined time points: 5 minutes after induction of GA (T2), 5 minutes after insufflation of the capnoperitoneum (T3), After the end of surgery and before recovery from anesthesia (T4).
by pressure controlled mode starting with an airway pressure of 15 cmH2O the subsquently changed ( decrease or increase) to provide targeted tidal volume according to each patient, maintaining end-tidal carbon dioxide between 35 to 45 mmHg with 5 cmH2O increments in PEEP until a peak pressure of 30 cmH2O will be achieved. Each PEEP level will be maintained for 5 s. The peak airway pressure will be maintained for 10 s or five breaths and subsequently reduced, followed by maintenance with the previous ventilator settings; Ultrasound guided maneuver will be performed at T2, T3 and T4.
The recruitment maneuver will be performed under ultrasound guidance until no collapsed lung area is visible. The strategy to increase the airway pressure will be the same as that for the conventional maneuver, although the maximal pressure limit will be 40 cmH2O. The Recruitment maneuvers (RM) will be started searching the pressure level at which the consolidation pattern disappears and progressive lung re-aeration is observed and will be recorded for all patients (the lung's opening pressure).(14) Lung ultrasound examination will be performed every 5 cmH2O increments in PEEP to detect the lung's opening pressure.
Other intervention name(s): control
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention