Cardiac Rehabilitation Program in Improving Cardiorespiratory Fitness in Stage 0-III Breast Cancer Survivors
Condition: Cancer Survivor; Stage 0 Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
MeSH terms: Breast Neoplasms; Breast Carcinoma In Situ
Study type: Interventional

Summary: 
      This clinical trial studies a cardiac rehabilitation program in improving cardiorespiratory
      fitness in stage 0-III breast cancer survivors. Cardiovascular disease is the leading cause
      of death of women in both the general population and the breast cancer survivor population.
      There are many risk factors common to both heart disease and breast cancer development,
      including physical inactivity. A cardiac rehabilitation program may help improve
      cardiorespiratory fitness, reduce cardiovascular disease risk factors, and improve quality of
      life among breast cancer survivors.
    

Detailed description: 
      PRIMARY OBJECTIVES:

      I. Assess the feasibility of conducting a 14-week cardiac rehabilitation (CR) program in
      women with breast cancer after completion of acute therapy.

      II. Preliminarily evaluate the efficacy of CR in improving cardiorespiratory fitness (peak
      oxygen uptake, maximum volume of oxygen [VO2 max]) at baseline and 14 weeks.

      III. Explore changes in cardiovascular disease (CVD) risk factors (blood pressure,
      cholesterol, fasting glucose, and body mass index) between baseline and 14-week follow-up.
      Blood pressure and body mass index will also be checked at 8 weeks.

      IV. Quantify the difference in quality of life (QoL) between baseline, 8 week, and 14 week
      follow up, adjusting for baseline QoL values.

      OUTLINE:

      Patients participate in a CR program consisting of 1-hour CR intervention sessions, based on
      a personalized exercise prescription, 3 times per week for 14 weeks (a total of 36 sessions).
      Components of the exercise prescription includes intensity, mode, duration, and frequency.
      Intensity of exercise is guided by the results of a graded exercise stress test, rating of
      perceived exertion (RPE), heart rate, and symptoms, such as chest pain/angina or shortness of
      breath. If exercise is well-tolerated during CR sessions, patients are encouraged to
      supplement their exercise program at home, increasing their exercise frequency to up to 5
      times per week. Patients may attend weekly educational sessions offered by the Phase 2 CR
      program which covers topics such as stress management, smoking cessation, nutrition, and
      weight loss.
    

Intervention name(s): Educational Intervention; Exercise Intervention; Quality-of-Life Assessment; Questionnaire Administration
Intervention type(s): Other; Behavioral; Other; Other
Intervention description(s): Attend weekly educational sessions; Participate in CR program; Ancillary studies; Ancillary studies
Other intervention name(s): Education for Intervention; Intervention, Educational; Quality of Life Assessment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care