Dileucine and Resistance Training Adaptations
Condition: Hypertrophy; Strength Training Adaptations; Weight-Bearing Strengthening Program
MeSH terms: Hypertrophy
Study type: Interventional

Summary: 
      This study seeks to compare the observed changes in resistance training adaptations after
      supplementation of isomolar amounts of leucine or dileucine in healthy resistance-trained
      men. This will provide a better understanding of supplementation with leucine versus
      dileucine over a 10-week period in regards to increasing muscular performance.
    

Detailed description: 
      The study will be conducted using a randomized, double-blind approach with individuals being
      provided daily 2-gram doses of leucine, 2-gram doses of dileucine, or a placebo. Daily
      blinded supplementation will occur each day for a 10-week period of time while completing a
      heavy resistance training program. Participants follow the resistance training program for a
      total of 10 weeks. To compare the efficacy of leucine in form of amino acid or dipeptide
      supplementation on resistance training adaptations, changes in fat-free, lean, and fat mass
      will be determined using a 4-compartment body composition model. Skeletal muscle
      cross-sectional area will be assessed using ultrasound. Maximal strength, muscular endurance,
      and power will also be assessed. Participants will be required to provide weekly compliance
      and complete one supervised workout per week. After 2, 6, and 10 weeks of following the
      supplementation and resistance training regimens, participants will return to the laboratory
      to complete testing bouts consisting of identical assessments of body composition, muscular
      strength, muscular endurance, lower-body power, and anaerobic capacity. Adverse events
      related to each supplementation group will be recorded and assessed.
    

Intervention name(s): Placebo; Leucine; Dileucine
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Participants will supplement daily for 10 weeks with 2 grams rice flower placebo in capsule form. On training days, participants will consume their assigned supplement within 60 minutes of completing their workout. On non-training days, participants will consume their assigned supplement with their first meal of the day. All doses will be consumed with 8-12 ounces of water.; Participants will supplement daily for 10 weeks with 2 grams leucine in capsule form. On training days, participants will consume their assigned supplement within 60 minutes of completing their workout. On non-training days, participants will consume their assigned supplement with their first meal of the day. All doses will be consumed with 8-12 ounces of water.; Participants will supplement daily for 10 weeks with 2 grams dileucine (RAMPS, Ingenious Ingredients, TX, USA) in capsule form. On training days, participants will consume their assigned supplement within 60 minutes of completing their workout. On non-training days, participants will consume their assigned supplement with their first meal of the day. All doses will be consumed with 8-12 ounces of water.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized, Double-Blind, Placebo-Controlled
Masking: Double (Participant, Investigator)
Primary purpose: Other
Keywords: Peptides; Dipeptide; Adaptations; Exercise; Dietary Supplements