Association Between Genetic Algorithm to Predict Hypertension Therapy and Response to Treatment
Condition: Hypertension
MeSH terms: Hypertension
Study type: Observational

Summary: 
      To assess the effectiveness of the use of a patient's genes to predict which hypertension
      therapy is successful
    

Detailed description: 
      Hypertension is known to have a strong heritable component. Previous work has demonstrated
      that sons of hypertensive patients are more likely to be hypertensive when compared to sons
      of normotensive individuals. Additionally, monozygotic twins are more likely to share
      hypertension than dizygotic twins who are more likely than non-twin siblings to share
      hypertension. Each of these previous studies demonstrate that genetics plays a role in the
      development of hypertension. For each major class of drugs (diuretic, vasodilator, and
      β-blocker) the effectiveness rate ranges from 40-60%. Contrary to common belief, even a small
      ~10-20% of patients have an increase in blood pressure with a given anti-hypertensive
      medication. These effectiveness rates go far beyond adherence in that these previous trials
      have controlled for medication adherence. In addition to this controlled studies,
      epidemiologic data has demonstrated that 40% of patients who take their medication, as
      prescribed by their clinician, do not have their blood pressure under control.

      Unfortunately, despite a significant impulse in the medical community to move towards an
      "individualized medicine" approach to patient centered treatment, the current clinical
      treatment strategy is based on a set algorithm which does not take into account individual
      patient differences. Rather, physicians are guided to choose a drug (one out of many options)
      in a given class of drugs and use that specific drug as a "first line therapy" (typically
      initiating with the diuretic class) and titrate that specific drug of choice to therapeutic
      dosage regardless of efficacy2. It is only after a prolonged course of treatment with that
      specific class of drug that clinical efficacy is determined (typically three months). At this
      stage, if clinical guideline goals for blood pressure have not been met, it is often
      recommended that the patient remain on the "first line therapy" whilst an additional drug
      from a different class of drugs (typically an Angiotensin converting enzyme inhibitor (ACE
      inhibitor) or Angiotensin II receptor blocker (ARB)) is added to the pharmacologic regimen.
      Again, this drug is titrated to recommended therapeutic dosage and another prolonged course
      of treatment is initiated before clinical efficacy is determined (an additional three months
      - six months since initiation of treatment). If at this point, clinical guideline goals for
      blood pressure have not been met, a third drug from a third class of drugs (typically a
      beta-blocker) is added and the process is repeated (another three months - nine months from
      initiation of treatment). Further, if clinical guideline goals have continued to be elusive,
      the diagnosis of refractory hypertension is added and the process is reinitiated with a
      different combination of drugs, different classes of drugs, different drug options within a
      given class of drugs, different dosages, or all of the above. Thus, from the time of initial
      diagnosis and the start of treatment to the point in which blood pressure is adequately
      controlled may take anywhere from three months to well over one year. This trial-and-error
      standard of care is clearly not optimal.

      The blood pressure panel created by Geneticure has been created to comprehensively assess
      seventeen common genetic variants in the liver (drug metabolizing enzyme) cardiac, vascular,
      and renal systems that can improve therapeutic guidance for the clinician based on known
      functional alterations of the protein through these genetic changes, as well as demonstrated
      effects of certain drug classes on these various genotypes. Based on this information, a
      clinician can guide therapy with knowledge specific to their patient, rather than
      "trial-and-error" based on population data and using drugs with least side effects initially.

      To assess the effectiveness of the use of a patient's genes to predict which hypertension
      therapy is successful, as measured by:

        1. Level of blood pressure control (<140/<90)

        2. Change in blood pressure from baseline to control
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Hypertensive patients who have achieved blood pressure control