Comparison of the Efficacy of Prolotherapy Injection Therapy & Local Anesthetic Injection Therapy.
Condition: Myofascial Pain Syndrome of Neck
MeSH terms: Myofascial Pain Syndromes; Fibromyalgia; Syndrome
Study type: Interventional

Summary: 
      Myofascial pain syndrome is a disease characterized by pain over the trigger point in a taut
      muscle band. After the correct diagnosis is made, many treatment methods can be applied.

      One of these treatments is the treatment with prolotherapy injection. Proliferant reveals
      defense mechanisms remove them and then start the healing process in the damaged area.
      Usually, dextrose water is used. Lidocaine is an anesthetic. With lidocaine injection, the
      passage of painful stimuli is prevented and the opioid system is activated. The aim of the
      study is to compare the efficacy of prolotherapy and lidocaine treatment in the myofascial
      pain syndrome.
    

Detailed description: 
      This is a prospective randomized controlled study. The population of the study consists of
      volunteer patients who can apply to Istanbul Physical Therapy and Rehabilitation Training and
      Research Hospital, and meet the inclusion criteria. Twenty-eight people will be selected from
      the participants who volunteered for the study and will be divided into the study group and
      control groups with the permutation block randomization method. At the beginning, all
      patients will be asked about their gender, age, body mass index, education level, occupation,
      duration of complaint, previous treatments, and the last time received treatment.

      Patients will be recruited equally to the control and study groups, with 14 patients in each
      group. 15% dextrose injection treatment will be applied to the study group. 2% lidocaine
      injection treatment will be applied to the control group. The subjects will be asked to sit
      on a chair and the trigger point will be determined in the upper trapezius muscle in both
      groups. A total of 3 sessions of injection treatment will be applied to the trigger points
      (at the beginning, at the 2nd, and 4th weeks). It will be planned to be 2 weeks between each
      injection session. 1 month after the third session injection, patients will be called for
      control purposes.

      The application will be made using a 25 gauge injector. Before the injection, the skin will
      be cleaned with alcohol and then dried. All patients will be injected into the trigger points
      in the upper trapezius muscle. Trigger point injection, on the other hand, is the compression
      of the isolated skin with the help of the thumb and middle finger and advancing the needle
      into the muscle at a 90-degree angle. Before the injection, a puncture will be made to make
      sure the needle is not in the blood vessel. Some of the mixtures will be injected into the
      trigger point and the rest around the trigger point. The same injection technique will be
      applied in both the control and study groups. Measurements will be made at the beginning
      (week 0), week 2, and week 4 before and after the injection when they come to the 1-month
      control. Adverse events related to injections will be recorded.
    

Intervention name(s): Dextrose solution; Lidocain
Intervention type(s): Drug; Drug
Intervention description(s): A total of 3 doses of dextrose prolotherapy will be administered with an interval of 2 weeks.; A total of 3 doses of lidocaine will be administered with an interval of 2 weeks.
Other intervention name(s): Dextrose prolotherapy; Local anesthetic
Intervention MeSH terms: Lidocaine; Anesthetics, Local; Anesthetics
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Prospective, randomized, triple blinded, clinical trials
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Lidocaine; dextrose prolotherapy; pain