Comparative Study Between Treatment With Cryotherapy Alone Versus Cryotherapy Plus Salicylic Acid Dressing for Planter Warts
Condition: Plantar Wart
MeSH terms: Warts
Study type: Interventional
Phase: Phase 1

Summary: 
      Verrucae plantaris (plantar warts) are a frequent cutaneous lesion of the plantar portion of
      the foot caused by the human papillomavirus (HPV) (HPV).Although HPV is ubiquitous in our
      environment, cellular and humoral immune responses typically prevent it from spreading or
      eliminate it.

      Warts can be painful and can lead to other difficulties, but there are some populations that
      are at a higher risk of getting HPV because they encounter the virus more frequently.

      In addition to infecting other people, HPV can also spread to other locations in the area.
      While reducing exposure to risk factors can help prevent plantar wart infection, HPV's
      widespread nature makes it difficult for such efforts to be effective.

      It has been shown in research that plantar warts can spread from person to person through
      just physical contact with the sores. Warts are more common in people with HPV because the
      virus disrupts the epithelial barrier. There are over a hundred different forms of the HPV
      virus, so even though some warts go away on their own after a few years, others may need
      medical attention.

      Warts, according to a number of studies, are extremely common (affecting around 10% of the
      population) all over the world. More cases of HPV infection have been observed among people
      under the age of 30, compared to those beyond the age of 30. The estimated prevalence in the
      United States is between 10% and 20%. However, people with compromised immune systems and
      those who work with meat are disproportionately at risk.

      The cancerous transformation of warts is quite rare. Even while verrucous carcinoma, a
      malignant form of wart development, is possible, it seldom spreads and only causes localised
      tissue loss.

      Plantar warts are treated in a manner that takes into account the patient's symptoms,
      personal preferences, and financial situation. Even though there are several therapy options,
      none of them are particularly effective, and relapses are common after any treatment. As a
      result, the most accessible and least distressing treatment option should be prioritised.

      Since salicylic acid can be used by the patient at home and does not require a doctor's
      prescription, it is often regarded a first-line therapy for the common wart. It can be as
      high as 70% effective in curing the disease. Other effective therapies for plantar warts
      include cryotherapy, retinoic acid, podophyllin, topical 5-fluorouracil, interferon, and
      imiquimod.

      Salicylic acid, in conjunction with cryotherapy, has shown therapeutic efficacy in patients
      with only foot warts, according to a single prior study. Patients who were given cryotherapy
      in this trial had a 58% success rate at recovery, whereas those given salicylic acid had a
      41% success rate. Hover, there is no discernible statistical difference.

      The purpose of this study was to compare the effectiveness of cryotherapy alone against
      cryotherapy plus salicylic acid dressing for planter warts, keeping in mind the prevalence of
      treatment for plantar warts and the lack of a well-established, practically applicable, and
      reliably preventative method in our local population.
    


Intervention name(s): Cryotherapy Alone; Cryotherapy plus Salicylic Acid
Intervention type(s): Procedure; Combination Product
Intervention description(s): Patients in Group A were subjected to Cryotherapy Alone with liquid nitrogen and received maximum of four treatments given two to three weeks apart .
The liquid nitrogen was applied with a spray or a probe; Patients in Group B were subjected to cryotherapy plus with 50% salicylic acid to be properly applied for a maximum of eight weeks The liquid nitrogen was applied with a spray or a probe
Intervention MeSH terms: Salicylic Acid; Salicylates
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Planter Warts; Cryotherapy; Salicylic Acid