bioihbjkbjnl/mcl2 huggingface dataset:
Mulligan Therapy Effects In Healthy Subjects With Induced Vertigo
Condition: Vertigo
MeSH terms: Vertigo; Dizziness
Study type: Interventional

Summary: 
      This analysis aims to evaluate the immediate effect that cervical sustained natural
      apophyseal glides (SNAGs) have on a group of individuals with induced vertigo by a caloric
      vestibular stimulation.
    


Intervention name(s): sustained natural apophyseal glides; SHAM SNAG
Intervention type(s): Procedure; Procedure
Intervention description(s): It consists on a sustained apophyseal glides in a postero-anterior direction on C2 with a dose of three series of ten repetitions each; Subjects on SNAG group received a simulation of the contact used for the SNAGs, without any vertebral glide, and with an active cervical extension
Other intervention name(s): SNAG
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Care Provider)
Primary purpose: Health Services Research
Comparison of Single İncision Laparoscopic Cholecystectomy Versus Laparoscopic Cholecystectomy
Condition: Laparoscopic Surgical Procedures
MeSH terms: Surgical Wound
Study type: Interventional

Summary: 
      The aim of this study is to compare outcomes of quality-of-life measures and evaluate the
      body image and cosmesis between Single Incision Laparoscopic Cholecystectomy (SILC) and
      Conventional Laparoscopic Cholecystectomy (CLC).Twenty eight patients underwent SILC and 30
      underwent LC.Fifty-eight patients were included the study and divided into two groups. The
      results of the questionnaires were statistically compared.
    

Detailed description: 
      Recently, single incision laparoscopic cholecystectomy (SILC) is one of the minimally
      invasive technique, developed to reduce the need of multiple ports and has become popular
      among the surgeons. This study was conducted with fifty eight patients between January 2011
      and March 2013 in Turkey. Fifty-eight patients were included the study and divided into two
      groups. Quality-of-life measures was evaluated by the EuroQol EQ-5D questionnaire.Cosmesis
      and body image were evaluated with the Body Image Questionnaire. All statistical analyses
      were performed by IBM Statistics 21.0 and MS-Excel 2007. A value of p<0.05 was accepted as
      statistically significant.
    

Intervention name(s): Laparoscopic Cholecystectomy (Single Incision); Laparoscopic Cholecystectomy (Conventional)
Intervention type(s): Procedure; Procedure
Intervention description(s): We performed Single Incision Laparoscopic Cholecystectomy (SILC) operation to the group-1; We performed Conventional Laparoscopic Cholecystectomy (CLC) to group-2
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Single İncision Laparoscopic Surgery; Conventional Laparoscopic Surgery
Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Erosive Gastroesophageal Reflux Disease (Phase 2, Therapeutic Exploratory Study)
Condition: Erosive Gastroesophageal Reflux Disease
MeSH terms: Gastroesophageal Reflux; Esophagitis, Peptic
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine the efficacy and safety of DWP14012 compared to
      esomeprazole in the treatment of erosive gastroesophageal reflux disease classified as Los
      Angeles(LA) classification grades A to D.
    


Intervention name(s): DWP14012; Esomeprazole; DWP14012 placebo; Esomeprazole placebo
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): tablet; tablet; tablet; tablet
Other intervention name(s): Nexium
Intervention MeSH terms: Esomeprazole; Fexuprazan
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Impact of the Cycle Ergometer in Muscle Strength and Pulmonary Function in Patients in Hemodialysis
Condition: Chronic Renal Disease; Renal Dialysis
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic; Kidney Failure, Chronic
Study type: Interventional

Summary: 
      Muscle strength can be measured by dynamometry, but the investigators did not find in the
      literature the study of this technique in the quadriceps of patients with chronic kidney
      disease on hemodialysis. Analyze training impact conducted by cycle ergometer in quadriceps
      muscle strength in patients with chronic kidney disease during hemodialysis. This study will
      be a prospective, randomized. Inclusion of 46 patients followed by the dialysis unit of a
      university hospital, over 18 years, of both genders who underwent hemodialysis for more than
      six months and signed the consent form and enlightened. Patients will be divided into two
      groups: Intervention (n = 23) and control (n = 23). All will be evaluated for demographics
      and quadriceps strength given by standardization of technique, with hard and windy belt. The
      control group will be reassessed after two months of the initial assessment, since the
      intervention group held two months of training in hemodialysis a physical therapy protocol
      with the cycle ergometer.
    


Intervention name(s): Cicloergometry training; No Cicloergometry training
Intervention type(s): Other; Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Muscle Strength; Muscle Strength Dynamometer; Chronic Renal Disease; Exercise; Physical therapy modalities
A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE)
Condition: Bloodstream Infections (BSI) Due to CRE; Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE; Ventilator-Associated Bacterial Pneumonia (VABP) Due to CRE; Complicated Urinary Tract Infection (cUTI) Due to CRE; Acute Pyelonephritis (AP) Due to CRE
MeSH terms: Infections; Communicable Diseases; Pneumonia; Urinary Tract Infections; Sepsis; Pneumonia, Bacterial; Pyelonephritis
Study type: Interventional
Phase: Phase 3

Summary: 
      This was a Phase 3 study containing a randomized open-label superiority cohort (Cohort 1)
      comparing the efficacy and safety of plazomicin with colistin when combined with a second
      antibiotic (either meropenem or tigecycline) in the treatment of patients with bloodstream
      infection (BSI), hospital acquired bacterial pneumonia (HABP), or ventilator-associated
      bacterial pneumonia (VABP) due to CRE. An additional cohort of patients with BSI, HABP, VABP,
      complicated urinary tract infection (cUTI), or acute pyelonephritis (AP) due to CRE, not
      eligible for inclusion in the other cohort, were enrolled into a single arm (Cohort 2) and
      treated with plazomicin-based therapy. Therapeutic drug management (TDM) was used to help
      ensure that plazomicin exposures lie within an acceptable range of the target mean
      steady-state area under the curve (AUC).
    


Intervention name(s): plazomicin; colistin; meropenem; tigecycline; antibiotic of Investigator's choice
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Other intervention name(s): colistimethate sodium
Intervention MeSH terms: Anti-Bacterial Agents; Meropenem; Colistin; Tigecycline
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Gram-negative; bacterial infection; antibacterial; antimicrobial; CRE; CPE; BSI; pneumonia; HABP; VABP; AP; cUTI; UTI
Delaying Alzheimer Disease Symptoms With Anti-Inflammatory Drugs
Condition: Alzheimer Disease; Dementia
MeSH terms: Alzheimer Disease
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether the anti-inflammatory drug celecoxib can
      delay the onset of Alzheimer Disease (AD) in people with Age Associated Memory Impairment
      (AAMI). This study will also evaluate genetic risk and brain structure as potential
      predictors of mental decline.
    

Detailed description: 
      AD is one of the most common mental disorders of late life. Preliminary studies indicate that
      anti-inflammatory drugs may attenuate or prevent AD symptoms, but efficacy trials are needed.

      Participants in this study will be randomly assigned to receive either celecoxib or placebo
      for 18 months. Participants will undergo positron emission tomography (PET) and magnetic
      resonance imaging (MRI) scans of the brain. Routine laboratory blood tests, cognitive tests,
      and an electrocardiogram (ECG) will be performed. Participants will also be screened for
      Parkinson disease. Follow-up testing will be conducted at specific intervals following the
      study.
    

Intervention name(s): Celecoxib
Intervention type(s): Drug
Intervention MeSH terms: Celecoxib
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Prevention
Acute Effect of Exercise on Vascular Function
Condition: Aging
Study type: Observational

Summary: 
      The study objectives are the following: 1) To examine the acute vascular responses to
      continuous low- and moderate-intensity exercise and interval training; and 2) To examine the
      influence of age and gender on these responses.
    

Detailed description: 
      The type, intensity and duration of exercise, fitness state, and timing of measurements have
      been reported to influence the acute vascular responses to exercise. However, little is known
      regarding the influence of interval training, aging and gender on these responses. The
      objectives of this study are: 1) to examine the acute vascular responses to continuous low-
      and moderate-intensity exercise and interval training; and 2) to examine the influence of age
      and gender on these responses. Subjects will perform the following 3 types of treadmill
      exercise in a random order: 1) slow-pace walking; 2) moderate-pace walking; and 3) interval
      training. Flow mediated dilation using high resolution ultrasonography and arterial stiffness
      using applanation tonometry will be measured before, immediately after and 1-hour after each
      acute bout of exercise.
    

Intervention name(s): Slow-paced walking; Moderate-paced walking; Interval Training; Treadmill
Intervention type(s): Other; Other; Other; Device
Intervention description(s): Subjects will complete 47 minutes of walking on a treadmill at a slow-pace.; Subjects will complete 47 minutes of walking on a treadmill at a moderate pace.; Subjects will complete 40 minutes of walking on the treadmill alternating between a moderate and a fast pace.
Observational model: Case-Crossover
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        General population including men and women 18 to 79 years of age
Treatment of Painful Digital Neuroma Using A Pedicled Nerve Flap
Condition: Painful Digital Neuroma
MeSH terms: Neuroma; Pain
Study type: Interventional

Summary: 
      Neuroma excision and digital nerve reconstruction remain the best option for the treatment of
      Painful Digital Neuroma (PDN). When the distal nerve end is preserved, conventional
      nonvascularized nerve grafting is the primary option to bridge the defect. The investigators
      hypothesize the pedicled nerve flap taken from the dorsal branch of the homolateral digital
      nerve is better than conventional methods for reconstruction of the digital nerve defect
      after painful neuroma resection.

      This study reports treatment of painful digital neuroma using a pedicled nerve flap taken
      from the dorsal branch of homolateral digital nerve. From May 2007 to March 2010, the
      patients had previous nerve injuries with or without nerve repair. The mechanisms of injury
      include sharp cut, avulsion and crush. The defects were between the middle of the distal
      phalanx and the palmar digital crease.
    

Detailed description: 
      Our selection criteria in this study included a patient with PDN in a scarred wound bed or
      poor coverage, a PDN located between the middle of the distal phalanx and the palmar digital
      crease, and a defect of the digital nerve after neuroma resection equal to or less than 3 cm
      in length. The exclusion criteria included a PDN in healthy soft tissue, a digital nerve
      defect longer than 3 cm, injury to the course of the pedicle or the donor nerve, and a thumb
      neuroma. A finger with a small distal end of the digital nerve was also excluded, because
      neurorrhaphy was extremely difficult in this situation.
    

Intervention name(s): Pedicled nerve flap
Intervention type(s): Device
Intervention description(s): This nerve flap is a vascularized nerve graft
Other intervention name(s): Surgical flap; Island flap
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Painful digital neuroma; nerve defect; dorsal branch of the digital nerve; digital nerve; pedicled nerve flap; Pain Disorder Associated with Psychological and Physical Factors
Cycloplegic Delivery Investigation
Condition: Healthy
Study type: Interventional

Summary: 
      The goal of this study is to compare the effectiveness of the administration of sequential
      drops, a combination drop and a combination spray for producing mydriasis and cycloplegia.
    


Intervention name(s): Mydriasis/cycloplegia via different modes of administration
Intervention type(s): Procedure
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
A Study of BAY3427080 (NT-814) in the Treatment of Moderate to Severe Post-menopausal Vasomotor Symptoms
Condition: Menopause; Hot Flashes; Night Waking
MeSH terms: Hot Flashes
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine the effectiveness of BAY3427080 (NT-814), taken
      once a day, in the treatment of troublesome post-menopausal symptoms.
    

Detailed description: 
      This is a multi-centre, multi-country, double-blind, randomised, placebo-controlled Phase 2b
      study. The study will have a single-blind run-in period and will be adaptive with respect to
      the number of subjects recruited into each dose group. Four doses of BAY3427080 (40 mg once a
      day, 80 mg once a day, 120 mg once a day and 160 mg once a day) will be investigated and
      compared to placebo, in five parallel groups. Subjects will participate in the study for a
      total of approximately 19 weeks, comprising a screening period of 1 week, a 14 week treatment
      period, and then a final follow up visit 4 weeks after the end of the treatment period. There
      will be a total of 8 visits whilst participating in the study. Subjects will record their hot
      flashes in an electronic diary during the screening period to establish eligibility and
      throughout the study after randomisation.
    

Intervention name(s): Elinzanetant (BAY3427080); Placebo
Intervention type(s): Drug; Drug
Intervention description(s): BAY3427080 capsules; Placebo capsules
Other intervention name(s): NT-814
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Vaginal Probiotics and Pessaries and Their Impact on the Vaginal Microenvironment
Condition: Pelvic Organ Prolapse; Inflammatory Response; Dysbiosis
MeSH terms: Prolapse; Pelvic Organ Prolapse; Dysbiosis
Study type: Interventional

Summary: 
      In this study, the investigators are evaluating the effect of vaginal probiotics on the
      bothersome side effects of pessary use and the impact on the vaginal microenvironment
      (lactobacilli, anaerobic bacteria, mobiluncus bacteria, WBCs, cellular debris, epithelial
      cells, and BVAB-1), and inflammatory environment (cytokines).
    


Intervention name(s): BiopHreshTM vaginal probiotic supplement (Good Clean Love, Inc. Eugene, OR) and RestoreTM gel.; Standard Care
Intervention type(s): Other; Other
Intervention description(s): BiopHreshTM is a vaginal probiotic supplement that is offered over the counter and contains four different lactobacilli strains (L. crispatus, L. gasseri, L. jensenii, and L. rhamnosus). RestoreTM is a moisturizing personal lubricant that has been on the market for three years. Participants will use 1 probiotic capsule with RestoreTM gel nightly three times weekly.; Standard care arm is standard care for pessary use. Pessary maintenance will be performed standardly by their provider.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants will be randomized to the treatment arm versus standard care arm.
Masking: Single (Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Pessary use; Probiotics; Cytokines; Microenvironment
A Dose-escalation Study to Evaluate the Safety, Tolerability, and Antitumor Activity of MEDI-573 in Subjects With Advanced Solid Tumors
Condition: Cancer
Study type: Interventional
Phase: Phase 1

Summary: 
      Evaluate the safety and tolerability of MEDI-573 in adult subjects with advanced solid tumors
      refractory to standard therapy or for which no standard therapy exists.
    


Intervention name(s): MEDI-573
Intervention type(s): Drug
Intervention description(s): Administered at a dose determined by the subject's enrollment cohort as an IV infusion as part of a 21 day treatment cycle.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Effect of Obesity on Endometrium in PCOS
Condition: Body Weight; Polycystic Ovary Syndrome
MeSH terms: Polycystic Ovary Syndrome; Syndrome; Body Weight
Study type: Observational

Summary: 
      The effect of Polycystic Ovary Syndrome (PCOS) with or without obesity has received a few
      attentions. There is a lack of evidence to whether the BMI affects the endometrial blood
      flow, which is necessary for implantation.
    


Intervention name(s): Doppler evaluation
Intervention type(s): Device
Intervention description(s): Endometrial volume, endometrial and subendometrial vascularity indices are measured by 3D power Doppler
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        100 women were recruited from gynecology clinic of Women Health Hospital
      
Keywords: endometrium
Efficacy and Safety of Tolvaptan in Cirrhotic Patients With Hyponatremia
Condition: Liver Cirrhosis; Hyponatremia
MeSH terms: Liver Cirrhosis; Hyponatremia
Study type: Observational

Summary: 
      This is a phase IV, open-label, prospective cohort study for 7 days.The recommended starting
      dose of tolvaptan is 15 mg daily orally. The dose may be titrated on the next day at 15 mg
      intervals up to 60 mg daily according to the serum sodium level response.Serum sodium level,
      change in sodium level from baseline, quality of life (EQ-5D-3L), change in body weight,
      edema, renal function, mortality and liver-related complications on day 7 and day 30 to
      evaluate the efficacy of tolvaptan in cirrhotic patients with hyponatremia.
    

Detailed description: 
      Tolvaptan is an effective treatment for hyponatremia. However, cirrhotic patients were
      underrepresented in previous studies. The pattern of use and efficacy of tolvaptan in
      real-life clinical practice are currently unknown.The objective of this study is to evaluate
      the efficacy of tolvaptan in cirrhotic patients with hyponatremia. The secondary objective is
      to evaluate the short- to intermediate-term safety of tolvaptan in cirrhotic patients.This
      will be a phase IV, open-label, prospective cohort study for 7 days. Although not mandatory,
      study subjects are encouraged to undergo follow-up assessments at 1 month.Subjects will be
      evaluated at designated time points after initiation of therapy. The primary efficacy
      endpoint is the proportion of subjects with normal serum sodium level (135-145 mmol/l) on day
      7. The secondary efficacy endpoints are serum sodium level, change in sodium level from
      baseline, quality of life (EQ-5D-3L), change in body weight, edema, renal function, mortality
      and liver-related complications on day 7 and day 30.
    

Intervention name(s): Tolvaptan; conventional thearpy
Intervention type(s): Drug; Other
Intervention description(s): Tolvaptan (OPC-41061) is a benzazepine derivative synthesized by Otsuka Pharmaceutical Company, Ltd. Tolvaptan was approved for the treatment of specific forms of hyponatremia by the United States (US) Food and Drug Administration (FDA) in May 2009, the European Medicines Agency on Aug 2009, Japan (Oct 2010), China (Sep 2011) and Korea (Sep 2011). Tolvaptan was approved for the adjunct treatment of volume overload in heart failure by the Japanese Ministry of Health, Labour, and Welfare (MHLW) in Oct 2010. It is also being developed for the treatment of autosomal dominant polycystic kidney disease (ADPKD), and for the treatment of hepatic edema.; conventional therapy with salt limitation ,et al
Other intervention name(s): OPC-41061; basic therapy
Intervention MeSH terms: Tolvaptan
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        The study population of this study will be patients with established cirrhosis and
        hyponatremia.
      
Biospecimen description: 
      plasma
    
Keywords: Cirrhotic Patients; Hyponatremia; tolvaptan