Comparison of Calcium Channel Blockers and Beta Blockers on Tourniquet-induced Hypertension During Intravenous Regional Anesthesia
Condition: Hypertension
MeSH terms: Hypertension
Study type: Observational

Summary: 
      The investigators aimed to investigate the efficacy of calcium channel blockers and beta
      blockers for controlling tourniquet induced blood pressure increase in patients undergoing
      carpal tunnel operations with IVRA. For this purpose files of patients undergoing operation
      under IVRA were retrospectively examined in terms of demographical and hemodynamic variables.
    

Detailed description: 
      After approval of the University Research Ethics Committee, the files of patients who have
      been operated under intravenous regional anesthesia (IVRA) in orthopedics clinics between
      January 2009 and January 2010 were retrospectively investigated. A total of 312 patients, 164
      patients with carpal tunnel syndrome and 148 patients with trigger finger have been operated
      under IVRA. Out of 164 patients who have been operated due to carpal tunnel syndrome, 50
      patients in which either calcium channel blockers or beta blockers were used for treatment of
      critical blood pressure increase after tourniquet inflation and in which whole data were
      obtained, were included to the study.The patients with systolic blood pressure above to 150
      mmHg following tourniquet inflation and in which bolus dose of diltiazem 10 mg (Group I) or
      calcium channel blocker 0.5mg/kg (Group II) have been administered by intravenous route
      constituted the study groups. Demographical characteristics and hemodynamic parameters were
      recorded from the patient files.
    

Intervention name(s): Calcium channel blocker and beta blocker
Intervention type(s): Drug
Intervention description(s): The patients in which systolic blood pressure increased to 150 mmHg and above following tourniquet inflation and in which a bolus dose of calcium channel blocker 10 mg (Diltizem, Mustafa Nevzat İlaç Sanayi Aş) (Group I) or beta blocker 0.5mg/kg (Brevibloc, Eczacıbaşı İlaç Sanayi Aş) (Group II) were administered intravenously constituted the study groups.
Other intervention name(s): Diltizem , Brevibloc
Intervention MeSH terms: Calcium Channel Blockers; Calcium; Adrenergic beta-Antagonists; Esmolol
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        The files of patients who were operated on under intravenous regional anesthesia (IVRA) in
        orthopedics clinics between January 2009 and January 2010 were retrospectively
        investigated. A total of 312 patients, 164 patients with carpal tunnel syndrome and 148
        patients with trigger finger were operated on under IVRA. Out of 164 patients who were
        operated on due to carpal tunnel syndrome, 50 patients in which either calcium channel
        blockers or beta blockers were used for treatment of critical blood pressure increase after
        tourniquet inflation and in which whole data were obtained, were included in the study.
      
Keywords: intravenous regional anesthesia