Evaluation of HALP Score in Preeclampsia
Condition: Pre-Eclampsia
MeSH terms: Pre-Eclampsia; Eclampsia
Study type: Observational

Summary: 
      Preeclampsia is a serious condition that can occur during pregnancy and can pose problems for
      both the mother and the baby. It occurs in approximately 2-8% of all pregnancies globally and
      is caused by issues with blood vessels, leading to elevated blood pressure and other related
      health concerns. Additionally, insufficient nutrition and inflammation within the mother's
      body may contribute to the development of preeclampsia.

      The HALP score serves as a tool to assess various elements within the blood, indicating
      inflammation or inadequate nutrition. Although it has been utilized in other medical
      contexts, its application during pregnancy remains limited. The HALP score has been employed
      to predict the emergence of ailments such as heart disease and cancer. Given that
      preeclampsia can stem from inflammation and poor nutrition, the potential of the HALP score
      in predicting the likelihood of preeclampsia during pregnancy is being examined through
      research.
    

Detailed description: 
      Preeclampsia is a hypertensive disorder affecting multiple body systems that poses a risk of
      maternal and fetal morbidity and mortality. The global prevalence of preeclampsia is
      estimated to be around 2-8% of all pregnancies. The pathophysiology of preeclampsia is
      complex and involves endothelial dysfunction and vasospasm, resulting in hypertension and
      end-organ damage. The development of preeclampsia is influenced by various factors, including
      abnormalities in the placenta, genetic factors, and maternal immune system. In addition, poor
      maternal nutrition and inflammation have also been identified as potential contributors to
      the development of preeclampsia.

      The HALP score is a composite measure of hemoglobin, albumin, lymphocyte, and platelet
      parameters that has been suggested as a possible indicator of systemic inflammation and
      malnutrition. Although the HALP score has not been extensively studied in obstetrics, it has
      been investigated in various medical fields as a predictor of adverse outcomes such as
      cardiovascular disease and cancer. Given the significance of inflammation and malnutrition in
      the development of preeclampsia, it is important to investigate the potential usefulness of
      the HALP score in predicting this condition.

      Due to the limited research on the application of the HALP score in obstetrics and the
      possible role of inflammation and malnutrition in the pathogenesis of preeclampsia, a
      retrospective study is being planned to explore the potential utility of the HALP score as a
      predictor of preeclampsia. By analyzing the relationship between the HALP score and the
      development of preeclampsia, valuable insights can be obtained regarding the potential
      involvement of inflammation and malnutrition in the development of this disorder.
    

Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        This study is a case-control retrospective study. Pregnant women between the ages of 18-44
        who were diagnosed with preeclampsia and healthy pregnant woman in our clinic and whose
        follow-up and birth were in our hospital
      
Keywords: preeclampsia; HALP score