bioihbjkbjnl/mcl2 huggingface dataset:
Wearable Sensors and Machine Learning for the Assessment of Biomechanical Risk in Lifting Tasks
Condition: Wearable Devices
Study type: Observational

Summary: 
      Lifting loads can cause work-related musculoskeletal disorders. The National Institute for
      Occupational Safety and Health (NIOSH) established a methodology for assessing lifting
      actions by means of a quantitative method based on intensity, duration, frequency, and other
      geometrical characteristics of lifting. Body-worn inertial sensor technology provides a
      number of opportunities to advance the safety and health of workers engaged in physical work.
      Motion-tracking systems together with Machine learning (ML) algorithms are used in the
      ergonomic field for biomechanical risk assessment by means of data acquired by wearable
      inertial systems. The investigators posed the question whether it is possible to classify
      lifting tasks belonging to different risk classes according to the value of LI using a
      machine learning approach by means of features extracted from raw signals. Aim of this study
      was to develop and validate, through ML algorithms, a non-invasive detection system of
      kinetic-kinematic parameters using IMU and EMG sensors, for the ergonomic assessment of the
      risk associated with a load lifting activity.
    

Detailed description: 
      The study envisages the voluntary enrollment of healthy subjects, referring to treatment
      clinics for work-related pathologies (excluding subjects aged <18 or > 65 years, and those
      with musculoskeletal pathologies or other disabling pathologies in progress), to carry out
      two repeated lifting tests. The two tests are set up to correspond respectively to the two
      NIOSH risk classes (LI<1, NO RISK; and LI>1, RISK). The IMU sensors provide wirelessly a
      series of data from which it is intended to extract a number of features (feature extraction)
      that have a high predictive power, through the digital signal processing technique using
      dedicated software (i.e. Matlab, SPSS). In a second step, data obtained from EMG sensors will
      be added to the analysis. Among the different artificial intelligence algorithms, the
      investigator will look for those most able to discriminate the various risk classes on the
      basis of the parameters extracted from the signals detected during the motor task.
    

Intervention name(s): wearable device
Intervention type(s): Device
Intervention description(s): IMU sensors and EMG sensors
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        healthy volunteer referring to treatment clinics for work-related pathologies
      
Keywords: inertial measurement units; Accelerometers; Ergonomics; Exposure assessment; Lifting; Work-related musculoskeletal disorders; Machine learning; Digital signal processing; Risk prediction
Repetitive Brake Activation
Condition: Eating; Obesity; Ileal Brake
Study type: Interventional

Summary: 
      The appearance of intact macronutrients in the small intestine induces an intestinal brake; a
      negative feedback mechanism from different parts of the intestine to the stomach, the small
      intestine and to the central nervous system. These processes inhibit food processing,
      appetite sensations and food intake, and furthermore they increase feelings of satiety and
      satiation. Several studies showed that intraileal infusion of nutrients resulted in a
      reduction in food intake. However only acute effects were investigated in these studies and
      thus far it is not known whether repetitive (intermittent) infusion results in adaptation to
      repeated exposure and, thus, a lowered ileal brake response.
    


Intervention name(s): Ileal infusion of casein; Ileal infusion of tap water
Intervention type(s): Other; Other
Intervention description(s): Intraileal infusion of casein; Intraileal infusion of tap water
Other intervention name(s): placebo
Intervention MeSH terms: Caseins
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: ileal brake
A Strategy to Improve Success of Treatment Discontinuation in Buprenorphine Responders
Condition: Opioid-use Disorder
MeSH terms: Opioid-Related Disorders
Study type: Interventional
Phase: Phase 3

Summary: 
      This study is an open--label randomized outpatient trial to evaluate feasibility and efficacy
      of rapid buprenorphine (BUP) discontinuation followed by brief course of treatment with
      long--acting naltrexone (XR--NTX) and to compare it to the standard method of gradual BUP
      taper.Individuals with opioid use disorder (OUD) (N=60) who have successfully completed at
      least 6 months of buprenorphine treatment and do not wish to remain in a long--term
      buprenorphine maintenance program will be recruited. The first phase includes a 4--week
      period of stabilization on buprenorphine 4--8 mg at the research clinic to assure that
      patients are stable, compliant, and free from illicit opioids. Participants that meet the
      above criteria will be randomized 1:1 to: 1) buprenorphine discontinuation and outpatient
      transition to XR--NTX with 3 monthly injections, or 2) buprenorphine discontinuation using a
      gradual 5-week long taper. In both groups participants will receive weekly relapse prevention
      therapy and will be monitored for the duration of the trial, which is 25 weeks post
      randomization.
    


Intervention name(s): Vivitrol; Buprenorphine
Intervention type(s): Drug; Drug
Intervention description(s): Oral naltrexone induction procedure followed by Vivitrol; 5-week buprenorphine taper
Intervention MeSH terms: Buprenorphine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: buprenorphine; naltrexone; Vivitrol; opioid dependence
Infuence of Kinesiotaping on Pulmonary Function Improvement in Multiple Rib Fracture
Condition: Chest Wall Injury
MeSH terms: Rib Fractures
Study type: Interventional

Summary: 
      Elastic tapes, named "kinesiotapes" have a limited, but proven influence on pain reduction,
      improvement in muscular strength and joint function. It can be hypothetised that by using
      kinesiotape techniques on damaged chest wall (due to mostly rib fracture) we can improve not
      only analgesia, but also improve lung function tests and speed recovery.
    

Detailed description: 
      Chest wall injury changes the function of chest wall muscles and other structures, which in
      turn influences respiratory function and cause significant pain.

      Elastic tapes, named "kinesiotapes" have a limited, but proven influence on pain reduction,
      improvement in muscular strength and joint function. It can be hypothetised that by using
      kinesiotape techniques on damaged chest wall (due to mostly rib fracture) we can improve not
      only analgesia, but also improve lung function tests and speed recovery.
    

Intervention name(s): Kinesiotape placement
Intervention type(s): Other
Intervention description(s): Placement of kinesiotapes, using ligament techniques on the injured side of chest, focusing on the point of maximal pain.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Tobacco Use in Pregnancy Intervention for Cessation
Condition: Pregnancy
Study type: Interventional

Summary: 
      The proposed project will test the effectiveness of the novel delivery of an established
      tobacco cessation treatment among pregnant women in Kentucky. Tobacco use during pregnancy is
      one of the most modifiable risk factors associated with poor birth and maternal outcomes and
      yet smoking prevalence among pregnant women in Kentucky is among the highest in the county
      and estimated to be twice that of the national average, with no meaningful declines observed
      in twenty years.
    

Detailed description: 
      The purpose of this pilot project is to test effectiveness of a tobacco-treatment cessation
      intervention (American College of Obstetricians and Gynecologists (ACOG) 5 A's) through use
      of a non-physician healthcare champion from within the clinic's existing infrastructure. This
      Tobacco use in Pregnancy Intervention for Cessation (ToPIC) will involve training the
      identified healthcare provider to become a Certified Tobacco Treatment Specialist (CTTS) and
      to administer the 5 A's to pregnant Medicaid patients receiving prenatal care through two
      high-volume Kentucky obstetrics clinics. This trial will provide evidence to evaluate this
      approach to delivering an established intervention in clinical practice.

      The Investigators propose to test the effectiveness of the clinical intervention by using a
      two-armed cluster randomized controlled design. Eligible participants will be randomized to
      the intervention (ToPIC) or standard of care for smoking cessation in pregnancy. This pilot
      project will gather quantitative and qualitative data for a mixed-method, multi-stakeholder
      process evaluation of intervention training and delivery. Furthermore, the Investigators' use
      of Medicaid claims data to examine healthcare utilization outside of maternal and infant
      well-care visits will enhance understanding of the strengths and limitations of these data
      for future evaluations. This study has the potential to significantly impact the most
      vulnerable in Kentucky, where rates of tobacco use among pregnant women are among the highest
      in the nation.
    

Intervention name(s): ToPIC; Tobacco Treatment As Usual (TTAU)
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Expanded tobacco cessation counseling for pregnant women.; Standard of care tobacco cessation counseling for pregnant women
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: pregnancy, smoking cessation, tobacco, preterm birth, ToPIC
Pain Treatment With Combinations of NSAIDs
Condition: Postoperative Pain, Acute
MeSH terms: Pain, Postoperative; Acute Pain
Study type: Interventional

Summary: 
      The search for new safe and effective methods of pain relief after surgery on large joints is
      still an urgent problem. The most optimal approach in the treatment of postoperative pain is
      the use of multimodal analgesia with a different mechanism of action that act on various
      mechanisms of pain and can include opioids, nonsteroidal anti-inflammatory drugs (NSAIDs),
      acetaminophen, anticonvulsants, NMDA antagonists, alpha-2-agonists, and sodium and calcium
      channel blocking agents, as well as local anesthetics. NSAIDs are the most popular and safe
      means for pain relief. Therefore, a lot of efforts are aimed at increasing the effectiveness
      of NSAIDs use. The aim of this study was to evaluate the effectiveness of simultaneously
      administering two or three NSAIDs, compared to using only one NSAID, for pain relief after
      surgery on large joints such as hip or knee arthroplasty.
    

Detailed description: 
      This is 6 days, randomized, double blind, parallel group, single-center study in 105
      subjects. The distribution into groups was carried out by sequentially alternating the set
      into 4 groups celecoxib 400 mg orally daily, aspirin 100 mg and ketorolac 90 mg orally daily,
      ketorolac 90 mg and celecoxib 400 mg orally daily; aspirin 200 mg, ketorolac 90 mg and
      celecoxib 400 mg orally daily.
    

Intervention name(s): Aspirin; Ketorolac; Celecoxib
Intervention type(s): Drug; Drug; Drug
Intervention description(s): The patients received aspirin in a dose of 100 mg orally daily.; The patients received ketorolac in a dose of 90 mg mg orally daily.; The patients received celecoxib in a dose of 400 mg orally daily.
Intervention MeSH terms: Aspirin; Celecoxib; Ketorolac
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Postoperative pain; Non-steroidal anti-inflammatory drugs; Combination of NSAID; Aspirin; Ketorolac; Celecoxib
An Eight-Week Study Evaluating the Efficacy and Tolerability of Two Doses of SSR149415 in Outpatients With Major Depressive Disorder
Condition: Depressive Disorder
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 2

Summary: 
      The objective is to evaluate the efficacy and safety of two doses of SSR149415 (250 mg and
      100 mg twice daily) compared to placebo and escitalopram 10 mg once daily in outpatients with
      major depressive disorder.
    


Intervention name(s): SSR149415
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: depression; antidepressive agents; controlled clinical trial
The Impact of MACA Supplementation on Basketball-related Performance
Condition: Sports
Study type: Interventional

Summary: 
      In this randomized crossover study, ten elite healthy male basketball players were included.
      Following a 17:00 PM training routine, participants completed a two-week supplementation with
      2000 mg of MACA or placebo. After supplementation, participants underwent a Basketball Jump
      Shooting Accuracy Test and Repeated Sprint Ability Test.
    

Detailed description: 
      Supplementation with Lepidium meyenii (MACA) has been shown in animal studies to increase
      blood lactate clearance and rapid lactate removal, which may be effective in reducing fatigue
      during intermittent exercise. However, no studies have investigated the effects of MACA
      supplementation on interval exercise and basketball performance. We hypothesized that MACA
      supplementation could reduce fatigue and improve performance in elite healthy male basketball
      players. This study aimed to determine the effectiveness of MACA compared to placebo on
      overall basketball performance.
    

Intervention name(s): Lepidium meyenii (MACA)
Intervention type(s): Dietary Supplement
Intervention description(s): The MACA supplement is derived from a concentrated 6:1 blend of black, red, and yellow MACA root compounds, with an 80:15:5 ratio respectively.
Other intervention name(s): 100% corn-starch maltodextrin powder
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: a double blind crossover study
Masking: Single (Investigator)
Primary purpose: Basic Science
Keywords: Lepidium meyenii; Basketball Jump Shooting Accuracy Test; Repeated Sprint Ability Test; blood lactate clearance rate; ergogenic aids
Early Versus Delayed Pushing in the Second Stage of Labor
Condition: Vaginal Delivery
Study type: Interventional

Summary: 
      Nulliparous women in spontaneous or induced labour with term singleton pregnancy are
      randomized into two groups first group (early pushing) in this group patients were allowed to
      push within one hour after full cervical dilatation whether the vertex was visible or not.
      Second group (delayed pushing) patients here were asked not to push for maximum of 3 hours or
      start pushing when the vertex was visible.
    

Detailed description: 
      Nulliparous women in spontaneous or induced labour with term singleton pregnancy are
      randomized into two groups first group (early pushing) in this group patients were allowed to
      push within one hour after full cervical dilatation whether the vertex was visible or not.
      Second group (delayed pushing) patients here were asked not to push for maximum of 3 hours or
      start pushing when the vertex was visible.

      Oxytocin was allowed in both group and fetus was monitored with CTG.
    

Intervention name(s): vaginal delivery
Intervention type(s): Procedure
Intervention description(s): vaginal delivery is carried by an expert obstetrician and the need for forceps or ventose is recorded
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Improving Survey Procedures for Young Men Who Have Sex With Men in Web-based HIV Prevention: Retention Study
Condition: Healthy
Study type: Interventional

Summary: 
      The purpose of this study is to test the efficacy of alternative methods to improve survey
      completion.
    

Detailed description: 
      Men who have sex with men (MSM) are the risk population most heavily impacted by HIV in the
      United States by any measure; in 2009, at least 61% of new HIV infections were estimated to
      have occurred in MSM. MSM are experiencing an increase in HIV transmission that has been
      occurring since at least 1990, and accelerated in multiple North American and European
      countries from 2000-2005. The expansion of the HIV epidemic has been proposed to be
      attributable, in part, to the extent to which the internet has facilitated sexual
      connectivity among MSM.

      Researchers have attempted to reach MSM for HIV prevention research and intervention on the
      internet. In the past 10 years, there has been a proliferation of internet surveys and HIV
      research studies among men who have sex with men that utilize the internet for data
      collection and, in some cases, the delivery of HIV prevention content. The development of
      internet-based interventions has been recently identified as especially promising because of
      its potential for scalability. However, there are also important limitations to
      internet-based data collections and prevention studies. The most important of these relate to
      representativeness and opportunities to introduce bias to data collections and differences in
      access to and use of internet among different subgroups of MSM. Equally important, although
      less discussed, are the unique ethical and human research protections challenges posed by
      online sexual health prevention studies.

      The investigators will conduct an experiment to improve knowledge of how to conduct
      internet-based HIV prevention research with MSM in ways that decrease biases in data
      collections. The design will consist of a randomized controlled trials of MSM recruited
      online. A total of 1000 MSM will be enrolled to determine how to best improve retention in
      online surveys.
    

Intervention name(s): Monetary Incentive; Altruistic Incentive; Dashboard Incentive
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): $20 Amazon.com gift card; A preliminary statement of the importance of participation, and periodic "inspirational" messages throughout the length of the survey emphasizing the value to men's health by completing the survey; A sample "dashboard" will compare data subjects enter in their survey to the data already collected from other men who have taken the survey. For the dashboard, men who complete the survey will be shown how their own reported data about certain topics compared to other men's data.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Condition: Pulmonary Hypertension
MeSH terms: Hypertension, Pulmonary; Hypertension
Study type: Interventional
Phase: Phase 3

Summary: 
      The present trial investigates the long-term safety, tolerability and efficacy of bosentan in
      patients with inoperable CTEPH.
    


Intervention name(s): bosentan
Intervention type(s): Drug
Intervention description(s): Oral bosentan
Initial dose: 62.5 mg twice a day (b.i.d.) for 4 weeks for all patients
Maintenance dose: 125 mg b.i.d. (62.5 mg b.i.d. if weight < 40 kg)
Intervention MeSH terms: Bosentan
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: pulmonary hypertension; bosentan; BENEFIT; CTEPH; inoperable chronic thromboembolic pulmonary hypertension (CTEPH)
To Evaluate the Efficacy and Safety of Collavant n2 in Individuals With Osteoarthritis of the Knee
Condition: Osteoarthritis, Knee
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional

Summary: 
      A randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of
      Collavant n2 in individuals with osteoarthritis of the knee.
    


Intervention name(s): Collavant n2 40 mg/day; Glucosamine hydrochloride & Chondroitin sulfate; Microcrystalline cellulose
Intervention type(s): Other; Other; Other
Intervention description(s): 2 capsules in the morning before breakfast and 2 capsules at night before going to bed for 180 days; 2 capsules in the morning before breakfast and 2 capsules at night before going to bed for 180 days; 2 capsules in the morning before breakfast and 2 capsules at night before going to bed for 180 days
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized, Parallel Group, Placebo Controlled Trial
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Transcranial Magnetic Stimulation for Depression in Autism Spectrum Conditions
Condition: Autism Spectrum Disorder; Major Depressive Disorder
MeSH terms: Depression; Depressive Disorder; Autistic Disorder; Depressive Disorder, Major; Autism Spectrum Disorder
Study type: Interventional

Summary: 
      In this research study the investigators aim to learn more about the therapeutic effects of a
      newer form of non-invasive transcranial magnetic stimulation (TMS), called theta burst
      simulation (TBS), on refractory depression in Autism Spectrum Conditions.
    

Detailed description: 
      The overarching goal of this study is to examine treatment effects and elucidate the
      physiological biomarkers of a newer form of non-invasive brain stimulation therapy on
      refractory depression in a sample of participants with ASC (autism spectrum condition).

      Aim 1: To compare the efficacy of 30-sessions of bilateral (BL) versus unilateral (UL) Theta
      Burst Stimulation to the dorsolateral prefrontal cortex (DLPFC) on depression severity in
      youth/young adults with ASC and co-occurring refractory major depressive disorder (MDD).

      Aim 2: To identify physiological markers of target engagement of successful response to
      either UL or BL on depression severity in youth with ASC and co-occurring refractory MDD.
      These physiological markers include high-resolution electroencephalography (EEG) markers,
      social eye-tracking, and handgrip strength (collected via NIH toolbox's motor toolbox
      domain).

      Aim 3: To identify feasibility of BL and UL in participants with ASC including systematic
      measures of safety and tolerability. This includes clinical measures such as rate of
      hospitalization and medication use.
    

Intervention name(s): Bilateral TMS; Unilateral TMS
Intervention type(s): Procedure; Procedure
Intervention description(s): Stimulation begins with continuous TBS to the right dorsolateral prefrontal cortex (DLPFC) (120 seconds of uninterrupted bursts; 600 pulses per session) followed by intermittent TBS to the left DLPFC (2 seconds on and 8 seconds off; 600 pulses per session); total duration of 3 min 9 seconds per hemisphere.; Stimulation involves only intermittent TBS to the left DLPFC (2 seconds on and 8 seconds off; 600 pulses per session); total duration of 3 min 9 seconds.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Transcranial magnetic stimulation; TMS; MDD; ASD; TBS; theta burst stimulation; autism; depression