bioihbjkbjnl/mcl2 huggingface dataset:
EFFECT OF EMOTIONAL FREEDOM TECHNIQUE ON PREMENSTRUAL SYNDROME
Condition: Premenstrual Syndrome
MeSH terms: Syndrome; Premenstrual Syndrome
Study type: Interventional

Summary: 
      PMS is one of the common menstrual disorders affecting many young women, and according to
      epidemiological data, approximately 75% of women have PMS symptoms and 3-8% have severe PMS
      symptoms. The prevalence of PMS was different in different countries, with 34% in China , 72%
      in Turkey , 80% in Pakistan and Jordan. It was detected in the range of 92% in India and
      14.3%-74.4% in India. Common premenstrual symptoms include anxiety, lack of concentration,
      depression, bloating, abdominal cramps, breast tenderness, anger, general body pain, nausea,
      vomiting, fatigue, decreased concentration, mood swings, headache, anxiety, sleep
      disturbance, appetite changes. In addition to physical symptoms, studies indicate that
      individuals reporting PMS experience more stress and anxiety, and their sensitivity to
      depressive symptoms increases due to hormonal fluctuations. Studies have shown that
      mindfulness-based cognitive methods are effective in the treatment of mood disorders such as
      depression. It is thought that modulating many PMS symptoms such as stress and experienced
      emotional problems through mindfulness-based cognitive methods may be an effective approach
      for future PMS interventions.
    


Intervention name(s): EFT
Intervention type(s): Other
Intervention description(s): Each student will be asked to voluntarily give their phone number and last menstrual cycle date, and the day will be determined for the first session. Then, the first EFT session will be made by the researchers by calling 14 days before the menstruation date. In the 2nd and 3rd sessions, a total of 3 sessions of EFT will be applied face-to-face by the researchers 14 days before menstruation. After each student completes three menstrual cycles, the researchers will meet with the student and PMSS will be applied as a post-test.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Emotional Regulation, Premenstrual Syndrome
V501 Safety and Efficacy Study in Japanese Women Aged 16 to 26 Years (V501-110)
Condition: Cervical Cancer; Cervical Intraepithelial Neoplasia; Adenocarcinoma in Situ
MeSH terms: Uterine Cervical Dysplasia; Adenocarcinoma in Situ
Study type: Interventional
Phase: Phase 4

Summary: 
      This study evaluated the long-term safety of quadrivalent Human Papillomavirus (HPV) types 6,
      11, 16, 18 vaccine and its effectiveness in the prevention of cervical intraepithelial
      neoplasia (CIN), adenocarcinoma in situ, and cervical cancer related to HPV in Japanese
      women.
    


Intervention name(s): V501
Intervention type(s): Biological
Intervention description(s): HPV types 6, 11, 16, and 18 vaccine 0.5 mL by intramuscular injection at Day 1, Month 2, and Month 6
Other intervention name(s): Gardasil™
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Role of Stem Cells, Platelet Rich Plasma in Treatment of Scars
Condition: Atrophic Scar
MeSH terms: Atrophy
Study type: Interventional

Summary: 
      The Objectives of this randomized controlled trial aiming to establishing a protocol of post
      scar revision care and to Study the effect of PRP and/or Adipose derived Mesenchymal Stem
      cell injection in improvement of atrophic scar after scar revision.
    

Detailed description: 
      Forty patients with atrophic scar since one to five years including 25 males and 15 females
      with ages ranging from ten to 35 years with main age of 22.68 will be divided into four
      groups each included ten patients. One group will be treated with scar revision only (control
      group or group I), 2nd group will be injected with PRP after scar revision, 3rd group will be
      injected with ADSCs after scar revision and the 4th group will be injected with a combination
      of PRP and ADSCs after scar revision. All groups were assisted pre-operative and six months
      post-operative. Complications, Scar width, Vancouver scar scale (VSS), surgeon assessment
      scar scale and patient assessment scar scale will be considered the outcome measurements.
    

Intervention name(s): Stem cell; MSCs
Intervention type(s): Biological; Device
Intervention description(s): after scar revision PRP is injected intradermally, also adipose derived mesenchymal stem cells; manual separation of platelets rich plasma and undifferentiated mesenchymal stem cells
Other intervention name(s): PRP; Stem cell and PRP
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: randomized controlled trial
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Atrophic scar; PRP; ADSCs
Fluorine-18-α-Methyltyrosine Positron Emission Tomography for Diagnosis and Staging of Lung Cancer
Condition: Carcinoma, Non-Small-Cell Lung
MeSH terms: Carcinoma, Non-Small-Cell Lung
Study type: Observational

Summary: 
      Objective: L-[3-18F]-α-methyltyrosine (FMT) is an amino-acid tracer for PET. We evaluated the
      diagnostic usefulness of 18F-FMT PET in non-small cell lung cancer (NSCLC) patients. Tumor
      uptake of 18F-FMT PET was compared with 18F-FDG PET and the correlation with L-type amino
      acid transporter 1 (LAT1) expression also investigated.

      Method: Fifty patients with NSCLC were enrolled in this study, and a pair of PET study with
      18F-FMT and 18F-FDG was performed. LAT1 expression and Ki-67 labeling index of the resected
      tumors were analyzed by immunohistochemical study.
    


Observational model: Defined Population
Time perspective: Prospective
Keywords: Fluorine-18-α-methyltyrosine,; Positron emission tomography,; Fluorodeoxyglucose; Lung cancer,; Amino acid transportor 1,; Ki-67; Proven or suspected non-small cell lung cancer were enrolled in the study
Brexpiprazole for the Long-term Treatment of Patients With Agitation Associated With Dementia of the Alzheimer's Type
Condition: Agitation Associated With Dementia of the Alzheimer's Type
MeSH terms: Dementia; Alzheimer Disease; Psychomotor Agitation
Study type: Interventional
Phase: Phase 3

Summary: 
      To evaluate the safety of brexpiprazole 1 mg or 2 mg after a 14 week treatment regimen for
      agitation associated with dementia of the Alzheimer's type patients who completed in a
      double-blind trial, and to investigate the efficacy of brexpiprazole.
    


Intervention name(s): Brexpiprazole
Intervention type(s): Drug
Intervention description(s): Brexpiprazole 1mg or 2mg will be orally once daily for 14 weeks
Other intervention name(s): OPC-34712
Intervention MeSH terms: Brexpiprazole
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Relapse Prevention Study of Pimavanserin in Dementia-related Psychosis
Condition: Dementia-related Psychosis
MeSH terms: Dementia; Psychotic Disorders; Mental Disorders
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to evaluate the efficacy of pimavanserin compared to placebo in
      preventing relapse of psychotic symptoms in subjects with dementia-related psychosis who
      responded to 12 weeks of open label pimavanserin treatment.
    


Intervention name(s): Placebo; Pimavanserin 34 mg; Pimavanserin 20 mg
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Placebo, tablets, once daily by mouth; Pimavanserin 34 mg total daily dose, tablets, once daily by mouth; Pimavanserin 20 mg total daily dose, tablets, once daily by mouth
Intervention MeSH terms: Pimavanserin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Dementia; Dementia-related psychosis; Dementia associated with Parkinson's disease; Dementia with Lewy bodies; Alzheimer's disease; Behavioral variant frontotemporal dementia; Progressive supranuclear palsy; Corticobasal degeneration; Vascular dementia; Hallucinations; Delusions; Psychosis
Study to Investigate the Effect of an Oral Diamine Oxidase Substitution (DAOsin) in Histamine Intolerant Patients on the Low Endogenous Diamine Oxidase Serum Activity
Condition: Food Intolerance; Histamine Intolerance
MeSH terms: Food Intolerance
Study type: Interventional

Summary: 
      DAOsin is a food supplement for special medical purpose for the treatment of food intolerance
      provoked by histamine intake. In this uncontrolled, interventional pilot study the effect of
      an oral diamine oxidase substitution (DAOsin) on the reduced endogenous diamine oxidase
      activity in histamine intolerant patients will be examined.

      Patients with a low endogenous diamine oxidase activity (below 10 Units/ml) take DAOsin for
      one month 3 times a day. During this month the diamine oxidase activity is tested biweekly.
      Afterwards a follow up period of one month without taking DAOsin follows. Again the diamine
      oxidase activity is tested biweekly.
    


Intervention name(s): DAOsin
Intervention type(s): Dietary Supplement
Intervention description(s): DAOsin is a food supplement for special medical purpose for the treatment of food intolerance provoked by histamine intake.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: food intolerance; histamine intolerance; diamine oxidase; DAO; DAOsin
Mindfulness Based Stress Reduction in Multiple Sclerosis (MS)
Condition: Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Sclerosis
Study type: Interventional

Summary: 
      This study focuses on stress, cognition, mood and fatigue and its effect on medication
      compliance. Medication compliance is measured by the weight of discarded needles. The
      investigators will be administering neuropsychological testing at baseline and the final
      visit. The subjects will complete self-report assessments during their 8 weeks in the study.

      Group A will have additional weekly phone support for meditation, while Group B will have
      meditation training only.
    


Intervention name(s): Mindfulness based stress reduction (MBSR)
Intervention type(s): Behavioral
Intervention description(s): Mindfulness based stress reduction (MBSR) is program based on daily meditation practice that guides an individual towards increased awareness and self-regulation of thoughts and actions. MBSR is easier to implement and may be shown to be more effective than cognitive-behavioral stress reduction, and is more applicable to patients with chronic illness.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Supportive Care
Keywords: multiple sclerosis; glatiramer acetate; stress reduction; medication adherence
Colostral Milk and Blood IL-6 Levels in Types of Labour
Condition: Indications for Care in Pregnancy; Labor; and Delivery
Study type: Interventional

Summary: 
      The comparison of serum and colostral melatonin, and IL-6 levels between women with vaginal
      delivery, emergency cesarean section and elective cesarean section
    

Detailed description: 
      In this prospective randomized study, the investigators aimed to show the changes in the
      melatonin levels in colostral milk in spontaneous vaginal delivery,emergency cesarean and
      elective cesarean section patients and changes in blood IL-6 level before and after the
      delivery in same patient groups.

      the investigators randomized 30 cases for each group for comparisons.Time range seems short
      in this study but participating hospital setting is a busy maternity hospital thus it will be
      performed easily.

      The purpose of this study is to demonstrate the beneficial effect of spontaneous vaginal
      delivery on the secretion of melatonin which is solely secreted by the mother and the newborn
      is dependent on maternal milk oriented melatonin until 12 th week after delivery
    

Intervention name(s): The calculation of blood IL-6 and coloctral milk melatonin
Intervention type(s): Other
Intervention description(s): Collected maternal colostral milk will be sampled for melatonin levels.Blood samples driven before and after delivery will be evaluated for IL-6 levels in each group
Other intervention name(s): No other intervention
Intervention MeSH terms: Melatonin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Screening
Keywords: melatonin,colostral milk,IL-6, delivery, cesarean section
Efficacy Comparison of Two Kinds of Treatment in Treating Dry Eye Caused by Meibomian Gland Dysfunction
Condition: Dry Eye Syndrome
MeSH terms: Dry Eye Syndromes; Keratoconjunctivitis Sicca; Meibomian Gland Dysfunction
Study type: Interventional

Summary: 
      This study aims to evaluate the efficacy of intense pulsed light in treating dry eye caused
      by meibomian gland dysfunction and make a comparison between the traditional treatment.
    


Intervention name(s): intense pulsed light; Tobramycin and Dexamethasone Ophthalmic Ointment
Intervention type(s): Device; Drug
Intervention description(s): Intense pulse light (IPL) has been used in dermatology practices for several years as a treatment for rosacea and acne.IPL uses Xenon flashlamp to emit wavelengths of light from 400 to 1200nm. When placed on the light, a filter restricts the wavelength to the visible light range of *500nm.In 2007-2008, an IPL treatment technology-the Diamond Q4 by DermaMed Solutions-was specifically configured to our specifications with the goal of stimulating secretion of normal meibum via skin treatment effects on the meibomian glands. It was discovered that dry eye patients are better positioned for gland expression, as IPL seems to liquefy the abnormal viscous meibum and dilate the glands.
Intervention MeSH terms: Tobramycin; Dexamethasone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: IPL; MGD
Nutrient Regulation of Amino Acid Transporters in Aging Human Skeletal Muscle
Condition: Healthy
Study type: Observational

Summary: 
      The goal of the research project is to determine how aging and inactivity reduce the muscle
      anabolic effect of nutrients and lead to muscle and functional loss. The central hypothesis
      is that aging reduces mTORC1 signaling and the expression of skeletal muscle amino acid
      transporters in response to anabolic stimulation leading to reduced muscle adaptation to
      increased intracellular amino acid requirements. The investigators further hypothesize that
      inactivity exacerbates this effect with significant muscle and functional loss, and
      rehabilitation restores muscle signaling, metabolism and function to baseline values.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        young and older healthy humans
Optimal Dosing of Preoperative Gabapentin for Prevention of Postoperative Nausea and Vomiting
Condition: Nausea, Postoperative; Vomiting, Postoperative; Pain, Postoperative
MeSH terms: Nausea; Vomiting; Pain, Postoperative; Postoperative Nausea and Vomiting
Study type: Interventional
Phase: Early Phase 1

Summary: 
      Overall incidence of postoperative nausea and vomiting (PONV) after general anesthesia is
      40-90 % . gabapentin has been incorporated into "fast-track" packages and improved recovery
      during surgery protocols to avoid unintended side effects associated with opioid
      alternatives. Interestingly, gabapentin has also been noted to reduce the effects of
      chemotherapy-induced nausea, effective in treatment of gravidarum hyperemesis, and postdural
      puncture emesis. Different dosing regimens were tested.The goal of the study is to determine
      the most effective dose of oral gabapentin given 1 hour prior to surgery on the occurrence
      and severity of PONV and drug side effects in the first 24 hours postoperatively to find the
      most effective dose of gabapentin with the least side effects.
    

Detailed description: 
      A total of (150) adult patients who will undergo elective abdominal laparoscopic surgery will
      be included in the study. Written informed consent will be obtained from all patients before
      randomization. Randomization will be done with the help of a computer generated list of
      numbers. Patients will be divided randomly and equally into three groups (50 patients each(.
      The first group of patients will receive 300 mg gabapentin orally 1 hour before induction of
      anesthesia by a sip of water (group G1), the second group of patients will receive 600 mg
      gabapentin orally 1 hour before induction of anesthesia by a sip of water (group G2), the
      third group of patients will receive 900 mg gabapentin orally 1 hour before induction of
      anesthesia by a sip of water (group G3). Drug formulation will be done by one of the
      researchers making the dosage of the three groups the same in number and shape of the
      capsules and then given to a junior anesthetist who is neither involved nor interested in any
      way in the sample to be administered to the patients surveyed
    

Intervention name(s): Gabapentin
Intervention type(s): Drug
Intervention description(s): Anticonvulsant, Antiemetic, Analgesic
Intervention MeSH terms: Gabapentin
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A total of (150) adult patients who will undergo elective abdominal laparoscopic surgery will be included in the study. Written informed consent will be obtained from all patients before randomization. Patients will be divided randomly and equally into three groups (50 patients each(.
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Prevention
Keywords: gabapentin; postoperative nausea and vomiting; laparoscopic surgeries; Visual analogue scale
A Proof of Concept Study of the Efficacy and Safety of Oral LAT8881 in Acute Migraine
Condition: Acute Migraine
MeSH terms: Migraine Disorders
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a randomised, placebo controlled, double blind, crossover proof of concept study to
      investigate the efficacy and safety of oral LAT8881 in acute migraine, with or without aura.
    

Detailed description: 
      Subjects enrolled in the study will be randomised to receive investigational medicinal
      product (LAT8881 60 mg or placebo), to be taken at the onset (within one hour from the onset
      of pain) of a migraine headache of moderate to severe intensity [Numeric rating scale greater
      than 4]. Rescue medication should not be taken until at least 2 hours post dose. Subjects
      will be given a single dose of either active or placebo, to treat one migraine headache.

      After treatment of one migraine headache (or a maximum 28 days) the subject will return to
      the clinic for re-evaluation and crossover to the second treatment. After treatment of one
      migraine headache in the second treatment period or a maximum of 28 days from commencement of
      the second treatment period, the subject will return to the clinic for re-evaluation. An End
      of study visit (telephone) will occur 7 days after the end of the second treatment period.
    

Intervention name(s): LAT8881; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Two 30 mg capsules of LAT8881; Two capsules of placebo
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Randomised assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Removal of Bacterial Spores in Adults on Skin
Condition: General Skin Cleansing
Study type: Interventional
Phase: Phase 4

Summary: 
      The aim of this study is to compare the effectiveness of removal of spores and dirt from the
      skin using a single cloth bath against a cloth bath with extra rinse step, to establish
      whether the extra rinse stage will lead to the removal of a higher level of spores and dirt.
    

Detailed description: 
      The purpose of this study is to evaluate and compare the ability of two test materials to
      remove Clostridium difficile (ATCC #700057) spores with a tripartite soil load from subjects'
      forearms. For this study, removal of Clostridium difficile and the associated organic soil
      load will be used as an indicator of potential removal efficacy for difficult-to-remove
      microorganisms and associated organic matter from human skin.

      All test materials are currently marketed products
    

Intervention name(s): Chlorhexidine Gluconate; HUBS with Hibiclens
Intervention type(s): Drug; Combination Product
Intervention description(s): A cloth to cleanse and disinfect the skin; A dry cloth to be used in combination with water and antimicrobial soap to cleanse and disinfect the skin
Intervention MeSH terms: Chlorhexidine; Chlorhexidine gluconate
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The two study products will be assigned to opposite forearms per a computer-generated randomization schedule. Additionally, the location for baseline and post-product samples will be randomly assigned to the two longitudinally-arranged sites per forearm.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Supportive Care