Atopic Diseases & Human Papilloma Virus
Condition: Human Papilloma Virus; Atopic Asthma; Atopic Disorders
MeSH terms: Papilloma
Study type: Observational [Patient Registry]

Summary: 
      Cervical cancer is an important health problem in women. Human papillomavirus (HPV) is
      considered the primary etiological agent of cervical cancer worldwide. Cervical cancer
      screening methods are proved one of the few screening methods that are thought to decrease
      invasive cancer incidence and mortality. In our country, HPV screening is carried out free of
      charge by public health to women between the ages of 30-65 aim is to compare HPV screening
      results between women diagnosed with atopic disease and healthy women without a history of
      atopy.If HPV is detected more frequently in patients with atopy, it may be recommended to
      follow more closely in vaccination and screening programs. Therefore, our study was designed
      to evaluate whether HPV positivity is common in atopic women.
    

Detailed description: 
      Patients between the ages of 30-65 with allergic complaints (sneezing, itching,runy nose,
      respiratory distress) were diagnosed "atopic disease" (allergic asthma, allergic rhinitis,
      allergic conjunctivitis, chronic urticaria and atopic dermatitis) by same clinician in
      Immunology and Allergy Department. Women aged between 30-65 years are scanned free of charge
      (HPV and smears) by the Public Health Institution in our country. The HPV results of the
      screened patients were noted retrospectively through the result reports of the patients, and
      those who were not screened were directed to Gynecology Department and HPV results were
      followed. Healthy women without allergic complaints applied for routine gynecologic
      examination occurred control group. Similarly, the HPV results of the control group were
      recorded.

      Pregnant women, women who receive immunosuppressive therapy (including chemotherapy and
      chronic corticosteroid therapy), HIV positive women, women with cancer and performed
      hysterectomy were excluded. Patients' height, weight, demographic features (age, marital
      status, income level), obstetric histories (gravida, parity, mode of delivery), contraception
      methods and smoking status were noted.

      Subgroup atopic disease diagnoses, duration of illness, treatments regimes and treatment time
      of the patients in the study group were also questioned and recorded. Leukotriene receptor
      antagonists and histamine receptor antagonists were the main treatments for study group and
      all therapies were designed by the same clinician. Routine allergic skin tests were performed
      to all atopic patients during diagnosis.

      Statistical analyses

      Statistical Package for Social Sciences (SPSS) for Windows, version 18.0 (SPSS Inc., USA) was
      used to compare the clinical features of groups. Normality of data distribution was tested
      with Kolmogorov-Smirnov test. Data was shown as means ± standart deviation (SD) for
      continuous variables and the independent t test was used to assess the differences in
      variables between groups. Kruskal-Wallis, Mann-Whitney U-test and Bonferroni correction were
      used for values with non-normal distribution. P Values below 0.05 (p<0.05) was accepted as
      statistically significant.
    

Intervention name(s): HPV test results
Intervention type(s): Other
Intervention description(s): The human papillomavirus (HPV) test detects the presence of the human papillomavirus, a virus that can lead to the development of genital warts, abnormal cervical cells or cervical cancer. The procedure includes taking samples of your cervical cells using a soft brush and a flat scraping device called a spatula. This doesn't hurt, and you may not even feel the sample being taken.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients between the ages of 30-65 with allergic complaints (sneezing, itching,runy nose,
        respiratory distress) were diagnosed "atopic disease" (allergic asthma, allergic rhinitis,
        allergic conjunctivitis, chronic urticaria and atopic dermatitis) by same clinician in
        Immunology and Allergy Department. Healthy women without allergic complaints applied for
        routine gynecologic examination occurred control group.
      
Keywords: Human papilloma virus,; screening test,; atopic diseases,; asthma,; rhinitis,; urticaria