The Best Dose of Esketamine for Day Surgery of Pediatric Circumcision Pediatric Circumcision
Condition: Phimosis
MeSH terms: Phimosis
Study type: Interventional

Summary: 
      In recent years, daytime operation has been developed gradually in China. Circumcision in
      children is a common type of daytime operation. The nature of the operation and the object of
      the operation determine that the anesthetic drugs used should induce fast, wake up quickly
      and recover in a high quality.

      Esketamine is an S-enantiomer of ketamine, which is newly marketed in China. Compared with
      ketamine, it has stronger effect on NMDA receptor, and its sedative effect is about twice as
      high. The occurrence frequency of respiratory depression and hypotension is lower than that
      of other anesthetics and analgesics, which can provide good analgesic and sedative effect for
      surgical anesthesia.

      In clinical practice, ketamine combined with sevoflurane has been widely used in children's
      microsurgery, but there has been no report on Esketamine combined with sevoflurane
      anesthesia.

      In order to find out the best combined dose, this paper compares the single administration of
      three different doses of esketamine combined with sevoflurane anesthesia in the circumcision
      of children.
    

Detailed description: 
      To investigate the optimal dose of esketamine combined with sevoflurane for pediatric
      circumcision. Methods children who underwent day surgery of pediatric circumcision were
      randomly divided into 3 groups according to the random number table method:0.5mg/kg
      esketamine group (Group A), 0.75mg/kg esketamine group (Group B) and 1.0mg/kg of esketamine
      group (Group C), with 30 people in each group. mask inhalation of sevoflurane anesthesia,
      each group was given a single intravenous dose of the corresponding esketamine. Heart rate
      (HR), mean arterial pressure (MAP), pulse oxygen saturation (SpO2) and respiratory rate (RR)
      were recorded at room entry (T0), intravenous ketamine administration (T1), operation
      initiation (T2), intraoperative central ligation (T3) and operation completion (T4).The
      number and total amount of ketamine added intraoperatively were recorded. Duration of
      operation, time to open eyes and time to answer were recorded. The Eastern Ontario Children's
      Hospital pain Score (CHEOPS score) and the modified Bieri pain score were recorded when
      awake, 2 hours and 6 hours postoperatie. MOAA/S score was recorded at 15, 30 and 60min after
      surgery. Intraoperative and post-operative adverse reactions were recorded, including
      hypersensitivity, agitation, nausea and vomiting, dizziness, diplopia, etc.
    

Intervention name(s): Esketamine
Intervention type(s): Drug
Intervention description(s): each group was given a single intravenous dose of the corresponding esketamine.
Intervention MeSH terms: Esketamine
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: children who underwent day surgery of pediatric circumcision were randomly divided into 3 groups according to the random number table method:0.5mg/kg esketamine group (Group A), 0.75mg/kg esketamine group (Group B) and 1.0mg/kg of esketamine group (Group C), with 30 people in each group.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Esketamine; Sevoflurane; Children; circumcise