Effect of the Composition From Fish on Promoting Hair Growth
Condition: Hair Loss/Baldness; Androgenic Alopecia; Male Pattern Baldness; Female Pattern Alopecia
MeSH terms: Alopecia; Alopecia Areata
Study type: Interventional

Summary: 
      According to the World Health Organization data, one out of every five Chinese men has a hair
      loss symptom, and the hair loss is as high as 84% before the age of 30. Based on the
      experience of clinicians, there seems to be an increasing trend of alopecia patients who seek
      the treatment in Taiwan.

      Treating pathological hair loss requires prompt diagnosis and management to prevent
      conditions that could lead to permanent hair loss. The current methods of treating hair loss
      include oral drugs, topical medication, laser illuminating treatment, platelet-rich plasma
      and hair transplant surgery. However, these treatments also have different disadvantages.
      Prolonged continuous use of oral and topical medications may be accompanied by side effects.
      Other treatment modalities may require higher costs, require return visits, or be more
      invasive.

      Previous study found that the composition of small DNA fragments (SF DNA) possesses not only
      toxin-free in primary human skin cells and nude mice, but also inhibits inflammation and ROS
      generation in the process of skin aging. SF DNA also contributes to promote the proliferation
      and differentiation of hair follicles, and stimulates the hair growth in nude mice through
      affecting JAK-STAT pathway.

      The investigators hypothesize that the clinical application of SF DNA scalp conditioning
      solution attenuates inflammatory responses, promotes the proliferation and differentiation of
      hair follicles, and increases the hair of hair loss patients and inspires the quality of
      life.
    

Detailed description: 
      Thick and healthy hair is a symbol, representing the attractiveness, youth, health and
      fertility of adults. However, according to the World Health Organization data, one out of
      every five Chinese men has a hair loss symptom, and the hair loss is as high as 84% before
      the age of 30. Based on the experience of clinicians, there seems to be an increasing trend
      of alopecia patients who seek the treatment in Taiwan.

      Excessive hair shedding potentially distributes to physiological effect which is in the
      senile hair-loss/postpartum state, or pathological effect which is due to thyroid
      disturbances, trauma, lupus erythematosus, scleroderma, drug effects, iron deficiency, or
      fungal infection. There are also two kinds of pathological hair loss, alopecia areata and
      androgen-derived hair loss, both of them are difficult to treatment in clinical so far.

      First-line interventions for treating excessive hair shedding include lifestyle modification
      and behavior therapy, such as clean scalp, adjusted daily routine, and alleviated
      psychological stress. The second-line interventions is drug therapy which is helpful in the
      treatment of excessive hair shedding, but respond to conservative measures. The minoxidil
      application is an effective treatment for androgenetic alopecia in both men and women. Its
      side effects include redness and scaling of the scalp. The finasteride reduces the
      dihydrotestosterone (DHT) in the serum and scalp, but it may cause sexual dysfunction.
      However, laser illuminating treatment, platelet-rich plasma (PRP) treatment, and surgical
      (hair transplant surgery) are cataloged to third-line interventions. The PRP treatment is
      safe, rapid, and process tolerable, and has the advantage of being finer and relatively
      low-cost compared to hair transplantation.

      Follicular units pre-treatment by PRP also facilitate increase of the survival rate of
      transplanted hair. Although light therapy does not have the side effects of percutaneous or
      oral administration, treatment with two to three times a week can also cause problems for
      patients. Autologous hair transplantation is a supplementary treatment for advanced
      androgenetic alopecia. However, the cost of hair transplantation is high, and the survival
      rate of hair after transplantation is also worrying. In addition, surgery during
      convalescence also produces the costs of hospitalization and the loss of productivity. These
      problems are worthwhile for most patients with excessive hair shedding. To minimize
      invasiveness treatment, the efficacy, safety, and cost-effectiveness should be considered.

      Our previous study found that the composition of small DNA fragments (SF DNA) possesses not
      only toxin-free in primary human skin cells and nude mice, but also inhibits inflammation and
      ROS generation in the process of skin aging. SF DNA also contributes to promote the
      proliferation and differentiation of hair follicles, and stimulates the hair growth in nude
      mice through affecting JAK-STAT pathway.

      The investigators hypothesize that the clinical application of SF DNA scalp conditioning
      solution attenuates inflammatory responses, promotes the proliferation and differentiation of
      hair follicles, and increases the hair of hair loss patients and inspires the quality of
      life.
    

Intervention name(s): SF DNA extraction composition; Placebo
Intervention type(s): Other; Other
Intervention description(s): the composition of small fragments of DNA from fish; the scalp conditioning solution without SF DNA extraction composition
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: Hair Loss/Baldness; Androgenic Alopecia; male pattern baldness; female pattern alopecia; sfDNA