bioihbjkbjnl/mcl2 huggingface dataset:
Amino Acid Composition Reduces Frequency of Common Cold. Results of a Controlled Completely Masked Trial
Condition: to Improve the Effectiveness of a Amino Acid Dietary Supplement in Chronic Pharyngeal Infections vs Placebo
MeSH terms: Common Cold
Study type: Interventional

Summary: 
      The purpose of this study is to investigate the effectiveness of a dietary supplement with
      high dosage of amino acids and vitamins in the treatment of acute and chronic infection of
      pharyngeal area known as common cold. T
    


Intervention name(s): amino acid composition; Placebo
Intervention type(s): Dietary Supplement; Other
Intervention description(s): one single pouch (13g) of amino acid mixture and vitamins diluted into 200 ml of still water. This solution was daily oral taken after a meal.; placebo contained no amino acids and vitamins and was identical in appearance and solution properties.
Other intervention name(s): Brand name: aminoplus immun; remedy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: amino acids; immune system; vitamins; chronic infection; common cold; ear; nose; throat
Aktiv i Sør: a Randomized Controlled Trial
Condition: Physical Activity
Study type: Interventional

Summary: 
      The purpose of this regional parallel-group RCT was to assess the effect of a six-month
      tailored telephone and email based physical activity intervention on various measures of
      physical fitness and body composition in a sample of physically inactive adults. A total of
      111 physically inactive adults (40-55yr) from Agder, Norway were randomly allocated to either
      an intervention group (IG;n=56) or a no-intervention control group (CG;n=55). The IG received
      tailored exercise recommendations, every two months by email or mail (print) in addition to
      motivational follow-ups every second week, alternatively by email and telephone. Primary
      outcome measures were various objective measures of musculoskeletal and cardiorespiratory
      fitness in addition to various measures of body composition, including waist circumference,
      body mass index and fat percentage, which were assessed pre- and post-intervention.
    


Intervention name(s): Intervention group - telephone and print exercise intervention
Intervention type(s): Behavioral
Intervention description(s): Intervention has previously been described.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Empowering Cancer Survivors Through Information Technology
Condition: Cancer Survivor
Study type: Interventional

Summary: 
      This is a randomized controlled trial of a web-based informational intervention (UMFollowUp)
      for adolescent and young adult survivors of childhood cancer to improve cancer knowledge and
      psychosocial functioning.
    

Detailed description: 
      Individuals randomly assigned to the control group will receive standard of care for the
      duration of their participation. This means they will continue to receive information
      regarding their diagnosis, treatments and ongoing health needs from their provider (no access
      to website).

      Individuals randomly assigned to the treatment group will receive access to UMFollowUp, a
      secure, HIPAA-compliant website.

      All participants will be asked to complete paper-and-pencil surveys at baseline and 9 months
      later to determine the impact of the web-based intervention.
    

Intervention name(s): UMFollowUp; Standard of Care
Intervention type(s): Behavioral; Other
Intervention description(s): Web-based internet resource for self-reported treatment summaries and psychosocial and physical well-being.; Patients will receive information regarding their diagnosis, treatments, and ongoing health needs from their provider, but will not be provided access to the website.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: cancer survivor
Efficacy and Safety Study for Subjects With Mild-to-Moderate Alzheimer's Disease
Condition: Alzheimer's Disease
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a efficacy and safety study evaluating new treatment for subjects with mild to
      moderate Alzheimer's Disease.
    

Detailed description: 
      This is a Phase 2 study designed to evaluate the efficacy and safety of ABT-126 in
      approximately 260 adults with mild-to-moderate Alzheimer's disease (AD). Subjects will be
      randomized to one of the four treatment groups (ABT-126, donepezil, or placebo) for a 12-week
      Treatment Period. Acronyms are listed in the secondary outcome section, below, you will find
      a list of the acronyms defined:

        -  MMSE - Mini Mental Status Exam

        -  QoL-AD - Quality of Life - Alzheimer's Disease

        -  CIBIC-plus - Clinician Interview-Based Impression of Change

        -  NPI - Neuropsychiatric Inventory

        -  CSDD - The Cornell Scale for depression in Dementia

        -  ADCS-ADL - Alzheimer's Disease Cooperative Study - Activities of Daily Living
    

Intervention name(s): Placebo; ABT-126; donepezil
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Placebo intervention; Experimental intervention; Active comparator intervention
Other intervention name(s): Sugar Pill; Aricept
Intervention MeSH terms: Donepezil
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Pharmacokinetic Study Of AGILE AG200-15 After Weekly Application Under Various Conditions in Healthy Female Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      A study to evaluate pharmacokinetic profile, wearability and safety of AG200-15, transdermal
      delivery of levonorgestrel (LNG) and ethinyl estradiol (EE), under normal conditions and
      external conditions of heat, humidity, cold water and exercise.
    

Detailed description: 
      Normal conditions - average daily living activities, Dry Sauna - 10 minutes at 168.8 - 179.6
      degrees Fahrenheit, Whirlpool - 10 minutes at 102.2 - 105.8 degrees Fahrenheit, Treadmill -
      20 - 30 minutes at 60-80% max heart rate, Cold Water - 5 - 15 minutes at 71.6 degrees
      Fahrenheit.

      There will be three treatment periods. Subjects will be randomly assigned to one of the five
      conditions for the treatment period. The subject will be exposed daily to the condition
      assigned while wearing the patch. The study patch will be worn for a 7 day treatment period,
      followed by a 7 day washout period. The total duration of the study is 6 weeks.
    

Intervention name(s): AG200-15
Intervention type(s): Drug
Intervention description(s): There will be three treatment periods. Subjects will be randomly assigned to one of the five conditions for the treatment period. The subject will be exposed daily to the condition assigned while wearing the patch. The study patch will be worn for a 7 day treatment period, followed by a 7 day washout period. The total duration of the study is 6 weeks.
Other intervention name(s): transdermal contraceptive delivery system, patch
Intervention MeSH terms: Contraceptive Agents
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Pharmacokinetic Profile (PK) and Safety; PK analysis of EE and LNG
Maternal Embryo Interaction in Recurrent Miscarriages
Condition: Recurrent Miscarriages
MeSH terms: Abortion, Spontaneous; Abortion, Habitual; Recurrence
Study type: Observational

Summary: 
      Background of the study:

      The etiology of recurrent miscarriage (RM, defined as three or more consecutive miscarriages
      without any proven maternal or fetal cause), remains undiagnosed in more than 50% of cases.
      In these cases it is generally considered that a disturbance in the normal mother-embryo
      interactions is a causal factor. This disturbance may be based on a dysregulation of embryo
      invasiveness and/or decidual acceptance (e.g. altered decidualization; endometrial changes in
      preparation for the acceptance of a putative pregnancy). Moreover, dysfunctional maternal
      immune regulatory natural killer (NK) cells, implicated in tolerance induction and
      trophoblast invasion,may also underlie the occurrence of RM. The Selection Failure hypothesis
      for RM suggests that super-receptive endometrium (possibly due to increased embryo
      invasiveness and/or decidual acceptance and/or dysregulated immune cell function) may allow
      'poor quality' embryos to implant and present as a clinical pregnancy before miscarrying.
      Fundamental knowledge on mechanisms of embryo implantation, decidual function and maternal
      immune reactivity in successful pregnancies has accumulated over the past 5 years. This study
      aims to investigate whether dysregulation of (one of) these mechanisms may underlie RM.

      Objective of the study:

      To test The Selection Failure hypothesis by assessing A) the degree of embryo invasiveness
      and decidual acceptance (the quality of decidualization, endometrium-embryo communication and
      endometrial stromal cell (ESC) migration) and B) the angiogenic capacity of decidual NK (dNK)
      cells, in order to elucidate the pattern of the mother-embryo equilibrium in women with RM.
    


Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Recurrent miscarriage group: primary care clinic Control group: primary care
        clinic/community sample
      
Biospecimen description: 
      endometrial biopsies and peripheral blood samples
    
Keywords: recurrent miscarriages (RM); recurrent pregnancy loss (RPL); fetal-maternal interface; decidualization; co-culture; implantation; immune regulation
The Effect of Aromatherapy on Cognitive Functions, Anxiety and Sleep
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      The aim of this study is to determine the effect of aromatherapy application on cognitive
      functions, anxiety and sleep quality in elderly people with diabetes.
    

Detailed description: 
      In addition to its physiological complications, diabetes is a disease that has negative
      effects on cognitive functions and is accompanied by anxiety and sleep problems. These
      problems negatively affect diabetes management and glycemic control. Ensuring glycemic
      control is the most important goal of diabetes treatment. The chronic and progressive nature
      of diabetes, the continuous increase in the number of individuals with diabetes and the
      accompanying problems lead the individual to seek alternative treatment methods in addition
      to clinical medical treatment. When the literature is examined, it is seen that aromatherapy
      is used in many clinical applications. Studies have shown the positive effects of lavender
      and rosemary and aromatherapy on cognitive functions, anxiety and sleep problems. However, no
      comprehensive studies on its effects in the elderly with diabetes were found. This study was
      planned to determine the effect of aromatherapy application on cognitive functions, anxiety
      and sleep quality in elderly people with diabetes.
    

Intervention name(s): Lavender aromatherapy; Rosemary aromatherapy; Control
Intervention type(s): Other; Other; Other
Intervention description(s): The application will be once a day, every day for four weeks. Each session will take five minutes.; The application will be once a day, every day for four weeks. Each session will take five minutes.; The application will be once a day, every day for four weeks. Each session will take five minutes.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Three groups: Lavender aromatherapy group, rosemary aromatherapy group and control group
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: diabetes; aromatherapy; elderly; anxiety; cognitive function; sleep
Low Level Laser Therapy for Hyposalivation
Condition: Hyposalivation
MeSH terms: Xerostomia
Study type: Interventional

Summary: 
      The aim of this study was to compare the effects of different wave lengths of LLLT on
      salivation in participants suffering from hyposalivation.

      This study included 30 participants whose major salivary glands were treated with low
      intensity diode laser BTL2000 (Medical Technologies, s.r.o., Czech Republic) during 10
      consecutive days. Patients were randomly assigned in two groups, each of 15 patients, and
      treated with LLLT of 830 nm and LLLT of 685 nm, respectively. The whole unstimulated and
      stimulated saliva was measured each day during 10 days, before and after laser treatment and
      10th day after treatment was ended.
    

Detailed description: 
      Low level laser treatment has proved to be effective for a wide range of oral pathologies
      including oral dryness, but the literature still lacks reports of clinical trials and
      protocols. The aim of this study was to evaluate the effects of two different laser wave
      lengths on salivation of patients suffering from hyposalivation. This with purpose to
      possibly find the optimum laser wavelength for the treatment, and to determine the better
      protocol for the patients suffering from hyposalivation. This study included 30 patients
      whose major salivary glands were treated with low intensity diode laser BTL2000 (Medical
      Technologies, s.r.o., Czech Republic) during 10 consecutive days. Patients were randomly
      assigned in two groups, each of 15 patients, and treated with LLLT of 830 nm and LLLT of 685
      nm, respectively. The whole unstimulated and stimulated saliva was measured in graduated
      tubes each day during 10 days, before and after laser treatment and 10th day after treatment
      was ended.
    

Intervention name(s): low level laser
Intervention type(s): Device
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: low level laser therapy; hyposalivation
The Impact of Heartfulness Program on Loneliness in High School Students in the US
Condition: Loneliness
Study type: Interventional

Summary: 
      This quantitative study assesses the baseline loneliness scores in all the high school
      students in the US. Assessments at baseline will include the UCLA loneliness scale. The
      Google form questionnaire will ask the high schoolers for their email address and their
      parent's email address (if they are under 18). The form will also include a question
      eliciting interest in participation in the 4-weeks Heartfulness program. The program will
      include tools that promote a heart-based nurturing environment focusing on relaxation,
      positivity, and developing growth mindsets.
    

Detailed description: 
      The specific aims of the study are:

        1. To assess the current level of loneliness in high school students through the UCLA
           loneliness scale.

        2. To assess the beneficial impact of the Heartfulness program on loneliness in high school
           students in the US.
    

Intervention name(s): Self-Care Program through Heartfulness
Intervention type(s): Behavioral
Intervention description(s): A four-week Self-Care program through Heartfulness will be offered to participants in the Heartfulness group. This would include a daily practice of relaxation tools for 15 minutes a day using an app and once a week webinar for 30 minutes. Guided relaxation and meditation sessions will be offered to the participants during the intervention weeks. These virtual sessions were conducted by Heartfulness Champions and certified trainers from Heartfulness Institute.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Supportive Care
Comparison of Two Types of Face Mask Ventilation in Obese Patients
Condition: Obesity, Morbid
MeSH terms: Obesity, Morbid
Study type: Interventional

Summary: 
      Two types of face masks : cuffed and uncuffed were evaluated for artificial ventilation in
      obese patients. After induction to anesthesia patients were ventilated with both types of
      masks using anesthesia machine with the same settings: Tital Volume of 500 ml, respiratory
      rate of 12/min. The inspired and expired volume was measured using anesthesia machine
      volumeter, The difference between inspired and expired volume was counted. The comparison
      between two types of masks was performed taking into consideration several parameters: type
      of obesity, gender, age.
    

Detailed description: 
      The aim of the study was to determine which of the tested: cuffed or uncuffed face masks
      allows better replacement ventilation in obese patients.

      The study was conducted on patients with the BMI over 39 kg/m2 Patients qualified for
      bariatric surgery were selected for this study according to the order of reporting to the
      surgery department. The study adopted a simplified assumption that the gynoid type of obesity
      most often concerns women, and the android type, i.e. abdominal obesity, most often affects
      men. Two face masks were used to compare the effectiveness of replacement ventilation: the
      cuffed and uncuffed . It was randomly chosen (by tossing a coin) which face mask would be
      used first. The induction of anesthesia was low-opioid, the patients were placed in the
      supine position with the head and trunk elevated by 25 degrees on a positioning pad. 100%
      oxygen concentration was used for active pre-oxygenation, the test mask was applied with one
      hand using the EC clamp technique. The masks were changed after four consecutive measurements
      for each type of mask. In order to objectify the measurement with the same tidal volume, a
      respirator was used with the same settings: Tidal Volume of 500 ml and respiratory rate of
      12/min. Sealing was measured by comparing the inspired volume with expired volume, that is
      the amount of leakage generated by individual masks was assessed. The obtained data were
      analyzed with the Kolmogorow-Smirnov test and supplemented with the values of the Wilcoxona
      test.
    

Intervention name(s): Ventilation using two types of face masks
Intervention type(s): Other
Intervention description(s): ventilation using two types of face mask
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: morbid obesity; face mask ventilation
XY-Zone Program Evaluation: A School-Based Dropout Prevention Program for At-Risk Youth
Condition: Adolescent Problem Behavior at School; Risk Behavior; Truancy; Socialized
MeSH terms: Problem Behavior
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The objective of this study is to build upon preliminary research and conduct a pilot
      feasibility randomized controlled trial on a promising culturally-grounded and
      gender-specific treatment program, the XY-Zone. The central hypothesis underlying this study
      purports that through receiving the XY-Zone treatment, adolescents will decrease their risk
      for dropping out of school. This hypothesis is supported by two years of preliminary data
      investigating the effectiveness of the XY-Zone.

      To test the central hypothesis, the following specific aims will be pursued:

        1. Identify school dropout risk and protective factors (protective factors defined as:
           adult support and peer support; risk factors defined as: low school attendance,
           inability to achieve grade promotion, substance use, delinquency, school
           disconnectedness, misbehavior, disconnection from healthy peers) directly changed as a
           result of XY-Zone intervention.

        2. Determine the extent to which moderating variables (affective strength, duration in the
           program, family functioning, interpersonal strength, intrapersonal strength, level
           achieved in the program, and resiliency) effect change in outcome variables (risk and
           protective factors).

        3. Identify participants' beliefs about the impact of the mechanisms of change (respect,
           responsibility, relationship, role modeling, and reaching out) on outcome variables
           (risk and protective factors ) to enrich understanding of quantitative data.
    


Intervention name(s): XY-Zone
Intervention type(s): Behavioral
Intervention description(s): The XY-Zone works to empower students to decrease risk factors and increase protective factors through three linear treatment steps. The first step is driven by guiding principles known as the five R's: respect, responsibility, relationship, role modeling, and reaching out. Through these principles, the participant explores healthy psychosocial behaviors and thoughts in a structured 10 session group setting. The leadership step builds upon the guiding principles and employs activities exploring true leadership through 10 sessions. During the leadership step, participants organize and carry out a service learning projects in their community. The third and final step is ambassador. Those in the ambassador step become a mentor to those in step one and are "expected to explore the principles of leadership and the five R's, and determine their personal relevance to their lives as young men" (Allen, 2009, p. i).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: XY-Zone; school drop-out risk; protective factors; truancy
Changes in Oxygen Saturation in Two Exercise Modalities
Condition: Muscle Oxigenation; Strength
Study type: Interventional

Summary: 
      The investigator will proceed to assess changes in oxygenation of muscle tissue,
      electromyographic activation and strength in healthy subjects. For this, a measurement of all
      demographic variables on the first day of the study as well as a familiarity with the
      equipment will be performed. Participants will start the intervention 48 hours later to
      proceed with the first intervention with one of the exercises in this research (inertial
      pulley or regular machine). Later on, 48 hours later participants will perform the latest
      intervention that has not yet done, thus generating a crossover study.
    


Intervention name(s): Iso inertial; Conventional machine
Intervention type(s): Device; Device
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Basic Science