bioihbjkbjnl/mcl2 huggingface dataset:
Assistance Multidisciplinary in Hypertensive Patient: Randomized Clinical Trial
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      The purpose of this study is to determine if multidisciplinary care improves the health
      condition of hypertensives.
    

Detailed description: 
      A multidisciplinary approach in managing hypertensive patients has shown benefits in reducing
      blood pressure and risk factors for hypertension.
    

Intervention name(s): Multidisciplinary assistance; Conventional treatment and follow up
Intervention type(s): Other; Other
Intervention description(s): Multidisciplinary group assistance was effected every two months by all professionals (physician, nurse, dietitian, physiotherapist and psychologist) and consisted in orientations and mechanisms to medication and non-pharmacological adherence (lifestyle changes).; Assistance was effected by physician and nurse and consisted about adapting to the drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: ambulatory care,; hypertension,; health personnel,; clinical trial
Program evaLuating the Autoimmune Disease iNvEstigational Drug cT-p13 in AS Patients(PLANETAS)
Condition: Ankylosing Spondylitis
MeSH terms: Spondylitis; Spondylitis, Ankylosing
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is the trial to demonstrate how our product is similar to remicade by comparing
      the results of blood samples in active Ankylosing Spondylitis patients.
    


Intervention name(s): Infliximab
Intervention type(s): Drug
Intervention description(s): Infliximab 5mg/kg is going to be administered for both arm as a 2-hour infusion per dose.
Intervention MeSH terms: Infliximab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Exercise as an Modulator of Immunological Risk Factors for Osteoporosis
Condition: Osteoporosis
MeSH terms: Osteoporosis
Study type: Interventional

Summary: 
      This is the second phase of a study designed to determine the immunological effects of
      long-term exercise on risk factors for ischemic heart disease (phase 1) and osteoporosis
      (phase 2). The results indicate that six months of moderate intensity exercise reduces bone
      resorption and increases the secretion of anti-osteoclastogenic cytokines by peripheral blood
      mononuclear cells.
    

Detailed description: 
      In a before and after trial involving 43 healthy adults the investigators measured the effect
      of six months of supervised exercise on the spontaneous and phytohemagglutinin-induced
      production of osteoclastogenic cytokines (interleukin-1α, tumor necrosis factor-α),
      anti-osteoclastogenic cytokines (transforming growth factor-β, interleukins 4 and10),
      pleiotropic cytokines with variable effects on osteoclastogenesis (interferon-γ,
      interleukin-6), and T cell growth and differentiation factors (interleukins 2 and 12) by
      peripheral blood mononuclear cells. The investigators also measured lymphocyte phenotypes,
      and serum markers of bone formation (osteocalcin), bone resorption (C-terminal telopeptides
      of Type I collagen), and bone homeostasis (estradiol, vitamin D2, testosterone, parathyroid
      hormone, insulin-like growth factor).
    

Intervention name(s): Supervised exercise program
Intervention type(s): Other
Intervention description(s): Subjects were enrolled in a hospital-based wellness center where, after analysis of their medical history and previous levels of physical activity ands documentation of a normal exercise stress test, they chose individually tailored exercise programs
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Exercise; Osteoporosis; Cytokines
Hemoglobin Easy Measurement With Optical Artificial Intelligence
Condition: Hemoglobin; Deficiency
Study type: Observational

Summary: 
      Blood hemoglobin levels are an extremely important measure for a large swath of medical
      procedures as they reflect the oxygen-carrying capacity of human blood. The gold standard
      measure for blood hemoglobin levels involve a venous blood draw followed by a
      laboratory-based complete blood count (CBC), a process which is both painful and time
      consuming. To date, various methodologies have been tested to either expediate the process or
      provide a non-invasive alternative. There remains a need to provide a quick,
      pain-free/non-invasive and accurate modality to measure blood hemoglobin levels. The
      objective of this study is to determine whether computer vision technologies can be applied
      to fingernail images captured via a smartphone camera to quantify blood hemoglobin levels.
    


Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Pediatric patients admitted to the Pediatric Department, Pediatric Emergency Department
        (PED) or Pediatric Hematology Unit (PHU) who have undergone a CBC
Food-related Differences in Human Metabolite Profiles
Condition: Healthy
Study type: Interventional

Summary: 
      Many population studies include food questionnaires (recording the normal food intake or the
      food intake of the study day). This is necessary, because diet is an important lifestyle
      factor, although food questionnaires are time-consuming and expensive. Moreover,
      mis-reporting is a very common problem. We therefore seek for a tool to validate food
      protocol.

      The hypothesis is to find biochemical marker for animal protein, fruit intake and grape
      consumption in urinary metabolic profiles after specific food consumption. Furthermore we
      want to specify biomarkers for different animal protein sources, fish and beef.
    

Detailed description: 
      Volunteers are asked to follow a diet plan over the whole course of the study. Every newly
      introduced food (in this study the dinner on days 2-5) will cause a change in biochemical
      marker excretion with urine. To monitor the kinetics of biomarker excretion it is necessary
      to collect urine several times a day; we will ask volunteers to collect the first morning
      urine, before lunch, before dinner and before going to bed. Urine sampling will start with
      the first morning urine on day 1 and end with first morning urine on day 7.

      As test food, we propose a fruit salad (apples, grapes, orange and grapefruit) on day 2, fish
      on day 3, grapes on day 4, beef on day 5 and again fish for lunch on day 6.

      From day 0 (run-in day) to day 6 the basic diet will always be bread and cheese for
      breakfast, coffee in the morning, a ham sandwich for lunch, and pasta and tomato sauce for
      dinner. As beverages only water will be allowed (although wine is permitted on day 4 if the
      subject wishes but this is not a protocol requirement). The test foods will be consumed in
      addition to that.

      All urine samples will then be analysed using high resolution NMR spectroscopy and mass
      spectrometry. Mathematical data analyses as well as the visual examinations of the NMR
      spectra will also be carried out to identify new food biomarkers.
    

Intervention name(s): fish, beef, fruit
Intervention type(s): Dietary Supplement
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Effect of Biodanza on Desire, Excitation and Sexual Inhibition
Condition: Sexual Desire Disorder; Sexual Arousal Disorder; Sexual Inhibition
MeSH terms: Sexual Dysfunctions, Psychological
Study type: Interventional

Summary: 
      the objective of this study was to examine the effects of a 10 weeks biodanza program on the
      sexual desire and inhibition/arousal of a sample of healthy young adults.

      A randomized clinical study was carried out, involving a total of 86 young adults divided
      into Intervention Group (BG) and Control Group (CG), carrying out biodanza sessions during 10
      weeks. The Sexual Desire Inventory (SDI) and the Sexual Inhibition/Sexual Arousal-Short Form
      Scale (SIS/SES-SF) were completed before and after the intervention.
    


Intervention name(s): Biodanza
Intervention type(s): Other
Intervention description(s): Intervention group received a total of 10 sessions, once a week, over the course of two months. Each session lasted 60 minutes. All sessions began with a 10-minute warm-up period combining music and low-intensity movements as a welcome round, followed individual exercises, in pairs and/or groups, which included dance combined with exercises based on the five lines of Biodanza (vitality, sexuality, creativity, affectivity and transcendence). Finally, a celebration and farewell round of 10 minutes was held. At the end of each session, the participants were asked to share their experiences with the rest of the group.
Other intervention name(s): Dance
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Biodanza; libido; sexual excitement; sexual inhibition; young adults; dance therapy; complementary therapies
Study to Assess the Impact on Calcium Levels When Hemodialysis Patients With Secondary Hyperparathyroidism (SHPT) Switch From Cinacalcet to Etelcalcetide
Condition: Hyperparathyroidism, Secondary
MeSH terms: Neoplasm Metastasis; Hyperparathyroidism; Hyperparathyroidism, Secondary
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a multicenter, multiple-dose, single-arm, open-label study to assess the impact on
      serum corrected calcium levels when switching patients from cinacalcet to etelcalcetide (AMG
      416).
    


Intervention name(s): Etelcalcetide
Intervention type(s): Drug
Intervention description(s): Etelcalcetide is provided as a sterile lyophilized powder to be reconstituted with sterile water for injection.
Other intervention name(s): KAI 4169; AMG 416; Parsabiv™
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Secondary Hyperparathyroidism (SHPT), chronic kidney disease (CKD), hemodialysis, parathyroid hormone (PTH), hypocalcemia, bone and mineral metabolism
A Study of ALXN1840 (Non-coated) Administered With And Without Omeprazole In Healthy Adults
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This was single-center, open-label, randomized, 3-period, 3-treatment, 6-sequence crossover
      study evaluating the PK of single doses of WTX101 in healthy participants based on the
      measurement of plasma total Molybdenum.
    


Intervention name(s): ALXN1840; Omeprazole
Intervention type(s): Drug; Drug
Intervention description(s): ALXN1840 (60 milligrams) was administered orally as non-coated capsules at Hour 0 on Day 1.; Omeprazole (20 milligrams) was administered orally as a delayed-release capsule in the morning of Days -5 to -1 and at Hour -1 on Day 1.
Other intervention name(s): WTX101 (formerly); Bis-choline tetrathiomolybdate; Tiomolibdate choline; Prilosec
Intervention MeSH terms: Tetrathiomolybdate; Choline; Omeprazole
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: This was single-center, open-label, randomized, 3-period, 3-treatment, 6-sequence crossover study.
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: ALXN1840; WTX101; Omeprazole
Acute and Chronic Responses to Blood Pressure After Exercise
Condition: Arterial Hypertension
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      The study will evaluate the variability of blood pressure in postmenopausal and hypertensive
      women after only one session and after training of ten weeks of combined physical exercises
      (aerobic and resisted).
    

Detailed description: 
      Before starting the training program, all the volunteers will sign the Free and Informed
      Consent Form (TCLE) and must present a medical certificate releasing the participation. In
      addition, the volunteers will respond to an anamnesis questionnaire and will undergo an
      anthropometric evaluation before the experimental sessions. The physical exercise program
      will be held three times a week for 10 weeks, containing aerobic exercise (exercise
      treadmill) and resistance exercises (bodybuilding). Initially, a familiarization of the
      ergometers used will be performed, followed by a session to evaluate the intensity of
      resistance exercise through a maximal repetition test (1RM), and a session to evaluate
      aerobic fitness through an incremental treadmill test.

      Before starting the training, volunteers will perform a single exercise session, following
      the same exercise protocol. All the volunteers will be submitted to the evaluation of the
      blood pressure during 24 hours through the measurement of ambulatory blood pressure (ABPM) in
      three moments:

        -  PR: pre-training rest - the volunteers will arrive at the laboratory, will be in rest
           for 15 minutes and after that they will place the ABPM, without having done any
           exercise.

        -  PE: post exercise - upon arriving at the laboratory, the volunteers will be submitted to
           a single combined exercise session, will have a maximum interval of 20 minutes for the
           bath and will place the MAP device.

        -  CR: rest after chronic training - after the end of the 10 weeks of training, the
           volunteers will be submitted to ABPM, again at rest, with a maximum interval of 72
           hours, between the end of the training and the placement of the device.
    

Intervention name(s): physical exercises
Intervention type(s): Other
Intervention description(s): The intervention will consist of a single session and after ten weeks of combined physical exercises (aerobic and resisted). All volunteers will participate in the same procedure.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Blood pressure variability; Combined physical exercise; Hypertension
Clinical Study Between Two 1% Clindamycin/5% Benzoyl Peroxide Topical Gel Formulations
Condition: Acne Vulgaris
MeSH terms: Acne Vulgaris
Study type: Interventional

Summary: 
      A randomized, double-blind, multiple-site, placebo-controlled, parallel-group clinical study
      conducted to evaluate the bioequivalence of two 1% Clindamycin/5% Benzoyl Peroxide Topical
      Gel formulations.
    


Intervention name(s): 1% Clindamycin/5% Benzoyl Peroxide Topical Gel; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Topical Gel; Placebo
Other intervention name(s): DUAC® 1% Clindamycin/5% Benzoyl Peroxide Topical Gel
Intervention MeSH terms: Clindamycin; Clindamycin palmitate; Clindamycin phosphate; Benzoyl Peroxide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Acne Vulgaris; bioequivalency; clindamycin; benzoyl peroxide
A Study of LY2216684 in Healthy Participants
Condition: Major Depressive Disorder
MeSH terms: Depressive Disorder; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will evaluate the pharmacodynamic and pharmacokinetic interaction of LY2216684
      with alcohol in healthy participants. This study will run approximately for 34 days.
    


Intervention name(s): LY2216684; Placebo-matching LY2216684; Placebo-matching alcoholic beverage; Alcoholic beverage
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Administered orally; Administered orally; Administered orally; Administered orally
Other intervention name(s): Edivoxetine
Intervention MeSH terms: Phenylethyl Alcohol
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Cognitive Behavioral Therapy Plus Drug Treatment for Obsessive Compulsive Disorder
Condition: Obsessive-Compulsive Disorder
MeSH terms: Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Study type: Interventional

Summary: 
      This study will evaluate the effectiveness of two cognitive behavioral therapies (CBTs) in
      treating obsessive compulsive disorder (OCD) in patients who are taking medication but still
      have residual symptoms.
    

Detailed description: 
      Participants remain on their current OCD medication and are randomly assigned to receive one
      of two CBTs: exposure and ritual prevention or stress management therapy. Exposure and ritual
      prevention involves imaginal and in-vivo exposure and requires that participants refrain from
      ritualizing. Stress management involves relaxation, assertiveness training, and structured
      problem-solving. Therapy occurs twice per week for 2 months. Participants are assessed
      verbally by an independent evaluator and are asked to complete self-rating forms. Patients
      who respond are followed for up to 1 additional year. Participants continue to take the same
      medication and the same monthly therapy for the first 6 months of follow-up. During the
      second 6 months of follow-up, participants discontinue therapy but continue taking the same
      medication.

      For information on a related study, please follow this link:

      http://clinicaltrials.gov/show/NCT00389493
    

Intervention name(s): Exposure and Ritual Prevention (Cognitive Behavioral Therapy); Stress Management Therapy (Cognitive Behavior Therapy)
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Cognitive Behavioral Therapy
Metformin Postpartum for GDM RCT for Reduced Weight Retention
Condition: Diabetes, Gestational
MeSH terms: Diabetes, Gestational
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to determine whether the study drug metformin is helpful in
      reducing weight after pregnancy in women with gestational diabetes. This pilot study will
      provide information on how well women are able to take metformin postpartum, whether
      metformin increases weight loss, and whether there are any increased risks of side effects to
      you as a new mother.
    

Detailed description: 
      At 24-48 hours after delivery, women who are eligible for participation will be approached
      and consented to the study. Maternal weight will be measured and 20ml of maternal blood will
      be obtained to assess glucose control and lipid profile. Women will be counseled regarding
      diet, exercise and glucose control. Data including maternal demographics, clinical
      characteristics and neonatal outcomes will be collected. At 3 weeks postpartum, a research
      nurse will contact the subject via telephone call to inquire about adverse or side effects,
      ability to take the prescribed medication (metformin or placebo), and to answer questions
      about the study. At 6 weeks postpartum, maternal weight will be measured , blood will be
      obtained and side effects will be evaluated again. Finally, a satisfaction survey will be
      completed.
    

Intervention name(s): Metformin; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Subjects will receive metformin 850 mg PO daily for 7 days, then metformin 850mg PO twice a day for the next 5 weeks; Subjects will receive a placebo (similar in size, taste, color) once daily for 7 days, then twice daily for the next 5 weeks.
Intervention MeSH terms: Metformin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Cognitive Behavioral Treatment of Posttraumatic Stress Disorder Enhanced by Virtual Reality for Individuals With PTSD and Substance Abuse
Condition: Posttraumatic Stress Disorder; Substance Abuse
MeSH terms: Substance-Related Disorders; Stress Disorders, Traumatic; Stress Disorders, Post-Traumatic
Study type: Interventional

Summary: 
      This study is exploring the use of an intervention designed to treat PTSD in individuals with
      comorbid PTSD and substance abuse resulting from the attacks of September 11 or from military
      service in Iraq. A cognitive behavioral treatment protocol will be used to treat PTSD. The
      exposure component of the protocol will be enhanced with the use of virtual reality in which
      the client will view a virtual environment while describing their trauma.
    


Intervention name(s): Cognitive behavioral treatment enhanced by virtual reality
Intervention type(s): Other
Intervention description(s): A cognitive behavioral protocol with cognitive and behavioral techniques will be used to treat symptoms. The exposure part of the treatment will be enhanced with the use of a virtual environment.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: PTSD; Substance Abuse; WTC attacks; Iraq War