Effects of Elastic Resistance Training on Performance and Biochemical Parameters
Condition: Exercise
Study type: Interventional

Summary: 
      The aim of this study was to investigate the acute and chronic effect of elastic resistance
      exercise in elderly women living in a nursing home. The primary outcome was the functional
      performance and hand grip strength. The secondary outcomes were myokines and inflammatory
      markers analysis.
    

Detailed description: 
      Evidence regarding the relationship between RT and systemic myokine responses, as well as
      inflammation and physical performance in elderly is limited. Thus, this study aimed to
      evaluate the effect of short-term progressive elastic resistance training on muscular
      strength and physical performance, as well as the acute and chronic response of myokines and
      inflammatory markers after resistance exercise in elderly women living in a nursing home.
      From January to February 2016, we invited 95 older women (≥ 65 years) living in nursing home
      in the south of Slovenia to participate in our study.

      The experimental design consisted of 1) baseline testing; 2) acute elastic resistance
      exercises with post-exercise and 2h post-exercise biochemical analysis; 3) a 3 months of
      supervised, progressive elastic resistance training program of moderate intensity; and 4)
      post-training testing.

      The quantification of biomarkers was done using the MAGPIX® system, magnetic bead-based
      multi-analyte panels and MILLIPLEX® Analyst 5.1 software (MAGPIX®, Merck Millipore) and a
      human premixed 4-plex kit (R&D System Inc., Minneapolis, MN, USA), strictly following the
      manufacturer's instructions.

      Two-way mixed ANOVA model was used to test group × time interaction. Tukey's post hoc test
      was applied for statistically significant interaction. To test for significant differences
      between groups relating anthropometric and biochemical variables, we used a Student's t-test.
      All values are expressed as mean and standard deviation (SD). P values of <0.05 is considered
      statistically significant. Bonferroni's correction for multiple testing will be performed by
      multiplying the P value with the number of tests where appropriate. Statistical analyses will
      be carried out using the SPSS program, version 21 (Chicago, IL).
    

Intervention name(s): Exercise; Training; Control group
Intervention type(s): Other; Other; Other
Intervention description(s): Exercise session consisted of general warm-up of 10 min, followed by 35-40 min of resistance exercises (chair squats, band seated: biceps curl, seated row, knee extension, leg press and hip abduction; standing behind the chair: knee flexion, and calf rise), and general cool down of 10 min.; Each training session consisted of general warm-up of 10 min, followed by 35-40 min of resistance exercises (chair squats, band seated: biceps curl, seated row, knee extension, leg press and hip abduction; standing behind the chair: knee flexion, and calf rise), and general cool down of 10 min.; The control group did not receive any treatment.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: BDNF; interleukin-15; interleukin-8; resistin; SPPB