bioihbjkbjnl/mcl2 huggingface dataset:
Microperimetric Evaluation After Half-dose Photodynamic Therapy for Chronic Central Serous Chorioretinopathy
Condition: Chronic Central Serous Chorioretinopathy
MeSH terms: Central Serous Chorioretinopathy
Study type: Interventional

Summary: 
      A half-dose photodynamic therapy, a relative new treatment, has been widely performed to
      treat central serous chorioretinopathy.

      The researchers aimed to investigate whether the therapy improved the patient's visual acuity
      as well as the retinal sensitivity. The researchers also investigate which clinical factors,
      if any, were associated with the results; visual acuity or retinal sensitivity after the
      treatment.
    

Detailed description: 
      The best-corrected visual acuity (BCVA), macular sensitivity, and fixation stability were
      evaluated at the baseline and at 1, 3, 6, and 12 months after the half-dose photodynamic
      therapy. The macular sensitivity and fixation stability were determined by MP-1
      microperimetry (Nidek, Vigonza, Italy). The researchers analysed whether the BCVA and retinal
      sensitivity significantly improved or not. And if yes, the researchers were interested at
      which period after treatment the significant improvement was found. Also, the researchers
      investigated which improved first, BCVA or retinal sensitivity.
    

Intervention name(s): half-dose photodynamic therapy
Intervention type(s): Procedure
Intervention description(s): photodynamic therapy (PDT) was performed using 3 mg/m2 body surface area of verteporfin (Visudyne, Novartis AG, Bülach, Switzerland) which is one-half the conventional dose of verteporfin. The verteporfin was infused over a 10 minute period followed by the delivery of 50 J/cm2 from a 689-nm laser system (Carl Zeiss, Dublin, CA) over an 83-second exposure time.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: microperimetry; fixation point; retinal sensitivity; photodynamic therapy; chronic central serous chorioretinopathy
Reciprocation vs Rotational Single-file Systems in Postoperative Pain
Condition: Apical Periodontitis; Assessment, Pain; Dental Pulp Necrosis
MeSH terms: Periodontitis; Periapical Periodontitis; Dental Pulp Necrosis; Pain, Postoperative; Necrosis
Study type: Interventional

Summary: 
      In this study, the researchers will investigate the effect of single-file reciprocating
      versus single-file rotational file systems on the postoperative pain in adult patients who
      have necrotic pulp and apical periodontitis. The participants will be assigned by chance to
      separate groups that compare 2 different treatments, reciprocating single-file system
      (Reciproc Blue) and rotational single-file system (OneShape). As a reference, Mtwo multi-file
      (full-sequence) will be used.
    

Detailed description: 
      The infected root canal treatments will be performed using one-visit approach with either a
      reciprocating single-file system or a continuous rotational single-file system. (Reciproc
      Blue reciprocating single-file system vs OneShape rotational single-file system). The root
      canals will be completed in single-visit. The patients will record their postoperative pain
      during the follow-up period using a VAS scale.
    

Intervention name(s): Reciprocating single-file system; Rotational single-file system.; Active comparator Protaper multi-file system
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): The device is moving in CW and CCW direction with different angles. It is a single-file endodontic file. The intervention is Reciproc Blue reciprocating single-file system.; The device is moving in continuous rotational. It is a single-fie endodontic file.
Other intervention name(s): Reciproc Blue; OneShape
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Relationship of Epicardial Adiposity With Sedentary Time, Physical Activity and Performance in Hypertensives
Condition: Hypertension
MeSH terms: Hypertension
Study type: Observational

Summary: 
      Epicardial adipose tissue is associated with the development of cardiovascular disease and
      its increase is positively correlated with blood pressure elevation in hypertensive
      individuals. In the literature, being physically active has been shown to be effective in the
      treatment of hypertension and reduction of epicardial adipose tissue thickness. The aim of
      this study was to evaluate the relationship between epicardial adipose tissue thickness and
      sedentary time, physical activity level and physical performance in patients with
      hypertension. The study included 40 patients with hypertension. The physical and demographic
      characteristics of the participants were collected using a sociodemographic form. Waist/hip
      circumference was measured with tape measure and epicardial adipose tissue thickness with
      echocardiography device. Physical activity levels and sedentary time were recorded via
      IPAQ-7. Physical performance was determined using the 30-s sit-and-stand test. There is no
      previous study in the literature evaluating the relationship between epicardial adipose
      tissue thickness and sedentary time and physical activity levels in hypertensive patients.
      With this study, we aim to contribute to the literature by filling this deficiency.
    


Intervention name(s): EPICARDIAL ADIPOSIS TISSUE AND PHYSICAL PERFORMANCE MEASUREMENT
Intervention type(s): Diagnostic Test
Intervention description(s): EPICARDIAL ADIPOSIS TISSUE AND PHYSICAL PERFORMANCE MEASUREMENT OF THE PARTICIPANTS WAS MADE.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Volunteers who had been diagnosed with hypertension for at least 6 months
      
Keywords: Epicardial adipose tissue; Hypertension; Physical activity; Sedentary time; Physical performance
Comparison of Preparation Regimens for Colonoscopy
Condition: Colonoscopy Preparation
Study type: Interventional

Summary: 
      The investigators intend to study the impact of two different preparation regimens for
      colonoscopy (PEG vs sodium picosulphate) on the quality of the endoscopy as well as patient
      tolerability.
    


Intervention name(s): one of two possible colon preparation regimens
Intervention type(s): Drug
Intervention description(s): Patients are randomized to receive one of the two different preparation regimens for colonoscopy usually employed in our unit, polyethylene glycol or sodium picosulphate and magnesium citrate
Other intervention name(s): Fortrans; Picoprep
Intervention MeSH terms: Picosulfate sodium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
A Study of Extended Use of Recombinant Human Parathyroid Hormone (rhPTH(1-84)) in Hypoparathyroidism
Condition: Chronic Hypoparathyroidism; Hypoparathyroidism
MeSH terms: Hypoparathyroidism
Study type: Interventional
Phase: Phase 4

Summary: 
      Chronic hypoparathyroidism is a life-long and irreversible disease for which the chronic
      administration of rhPTH(1-84) is a potential treatment option. The group of participants in
      the AAAE0544 core study has been taking rhPTH(1-84) for the treatment of hypoparathyroidism
      for up to 11 years. This study is designed to extend this experience and gain knowledge about
      how safe and effective rhPTH(1-84) is in participants with hypoparathyroidism over a
      long-term duration.
    


Intervention name(s): rhPTH(1-84)
Intervention type(s): Drug
Intervention description(s): Participants will receive 25, 50, 75, and 100 microgram (mcg) of rhPTH(1-84) subcutaneous injection to the thigh via a multidose pen injector device once daily for 36 months. The dose will be individualized based on Albumin-corrected Serum Calcium (ACSC) and 24-hour calcium urinary excretion to achieve a serum calcium level in the lower half of the normal range.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effects of Methylphenidate on Cellular Abnormalities in Children With Attention Deficit Hyperactivity Disorder (ADHD)
Condition: Attention Deficit Hyperactivity Disorder
MeSH terms: Hyperkinesis; Congenital Abnormalities; Attention Deficit Disorder with Hyperactivity
Study type: Interventional
Phase: Phase 2

Summary: 
      This study will assess the frequency of chromosomal abnormalities measured in circulating
      lymphocytes in treatment-naive children with Attention Deficit Hyperactivity Disorder (ADHD)
      treated for 3 months with either extended release methylphenidate or behavioral therapy.
    

Detailed description: 
      This study will determine whether the administration of extended-release methylphenidate in
      treatment-naïve children with Attention Deficit Hyperactivity Disorder (ADHD) affects the
      frequency of chromosomal abnormalities.
    

Intervention name(s): Extended Release Methylphenidate (Ritalin LA ) plus Behavior Therapy; Behavior Therapy
Intervention type(s): Drug; Behavioral
Other intervention name(s): Ritalin LA
Intervention MeSH terms: Methylphenidate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Attention Deficit Hyperactivity Disorder,; ADHD; Cytogenetic abnormalities,; extended-release methylphenidate,
A First In Human Study to Assess CiVi007 in Subjects With an Elevated LDL-Cholesterol Level
Condition: Hypercholesterolemia
MeSH terms: Hypercholesterolemia
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of the study is to assess pharmacokinetics, dynamics, safety and
      tolerability of CiVi007 following single and multiple subcutaneous doses in subjects,
      including those on statin therapy
    


Intervention name(s): CiVi007; Placebo
Intervention type(s): Drug; Other
Intervention description(s): cholesterol lowering drug; matching placebo to CiVi007
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Adaptive design allowing modifications in single and multidose arms
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Comparison of Postoperative Pain Between Patients Received Primary and Repeated Caesarean Section
Condition: Caesarean Section
MeSH terms: Pain, Postoperative
Study type: Observational

Summary: 
      To everyone knows, more and more patients received repeated caesarean section in China.
      However, at present it is not known what is it like about their postoperative pain intensity,
      and is it different from those patients who received primary caesarean section. Thus through
      postoperative follow-up, the current study aimed to investigate and compare the postoperative
      pain between patients received primary and repeated caesarean section.
    

Detailed description: 
      According to whether or not to receive repeated caesarean patients were grouped into group P
      or group R. For all maternal,standardized epidural anesthesia and caesarean section were
      performed. Then the pain VAS scores and Ramsay scores at 4h, 8h, 12h, 24h and 48h after the
      surgery were recorded. And sleep quality at 1 day and 2 day after the surgery were recorded.
      In addition, pain situation at 1 week and 4 weeks after the surgery was followed up.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients who receiving primary and repeated caesarean section.
Bioequivalence of Xaroban 20mg (Rivaroxaban) Tablet and Xarelto 20mg (Rivaroxaban) Tablet Under Fed Conditions
Condition: Bioequivalence
MeSH terms: Malnutrition
Study type: Interventional
Phase: Phase 1

Summary: 
      A single center, open label, randomized, single-dose, two period, Two way cross-over study to
      explore the Bioequivalence of Test Product Xaroban (Rivaroxaban) 20 mg Tablet with the
      reference product Xarelto (Rivaroxaban) 20 mg tablet under fed conditions in healthy
      Pakistani male subjects. Subjects will receive one single dose per treatment period separated
      by a wash-out period of 7 days. Blood samples will be taken up to 48hours post-dose.
    

Detailed description: 
      Single oral administrations of study drug in two periods separated by a washout period of 07
      days. Subjects will take their assigned study medication orally, together with 240 mL of
      ambient temperature water, at least 1 hour after start of the meal at their scheduled dosing
      time-point. Total duration of treatment of study drug will be of 58 hours comprising 10 hours
      prior drug administration until 48 hours post dose in each study period.

      Pharmacokinetic parameters include Rivaroxaban plasma concentrations at the given sampling
      times. In each period 16 blood samples for plasma Rivaroxaban concentrations will be taken on
      Day 2, Day 3 and Day 4 including 0.00 hour pre dose and post dose at 0.25, 0.5, 1.00, 1.50,
      2.00, 2.50, 3.00, 3.5, 4.00, 6.00, 8.00, 12.00, 24.00, 36.00 and 48.00 hours.
    

Intervention name(s): Rivaroxaban 20 MG Oral Tablet
Intervention type(s): Drug
Intervention description(s): The subjects randomly received single oral dose of Rivaroxaban 20 MG Tablet.
Intervention MeSH terms: Rivaroxaban
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Two period Two way cross-over study
Masking: None (Open Label)
Primary purpose: Other
SPARK Symptom Screening and Feedback to Providers
Condition: Pediatric Oncology; Quality of Life
Study type: Interventional

Summary: 
      Supportive care Prioritization, Assessment and Recommendations for Kids (SPARK) is a
      web-based application which builds upon the Symptom Screening in Pediatrics Tool (SSPedi) and
      consists of two components: (1) a symptom screening component centered on SSPedi; and (2) a
      supportive care clinical practice guideline (CPG) component. This proposal is a randomized
      controlled trial that compares daily completion of SSPedi via SPARK for 5 days with symptom
      feedback to healthcare providers compared with standard of care
    

Detailed description: 
      Participants will be children with cancer or hematopoietic stem cell transplantation (HSCT)
      recipients who are 8-18 years of age and who can understand English, and who are expected to
      be in hospital or in clinic daily for 5 days. This will be a multi-center RCT in which we
      will randomize children to either undergo daily symptom screening for 5 days with symptom
      reports provided to the healthcare team or standard of care. The primary outcome will be the
      self-reported day 5 total SSPedi score (range 0-60; higher worse). Secondary outcomes will be
      the day 5 self-reported individual symptom, pain and QoL scores, and documentation of
      symptoms and provision of interventions for symptoms over the 5 day trial. We will enroll 345
      participants over 4 years from 7 Canadian centers
    

Intervention name(s): SPARK
Intervention type(s): Other
Intervention description(s): see above
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Pediatric Oncology; Randomized Control Trial; Symptom Screening; Quality of Life
Gonadotropin Type in Ovarian Stimulation
Condition: Infertility
MeSH terms: Infertility
Study type: Interventional
Phase: Phase 4

Summary: 
      A key challenge facing reproductive biologists is the integration of the knowledge about
      oocyte-secreted factors into coherent physiological mechanisms of how oocytes govern
      folliculogenesis, cumulus cell function, and oocyte and embryo development. Although key
      oocyte-secreted factors have been identified, understanding their modes of action is
      complicated by multiple interactions between maternal and oocyte signaling molecules, as well
      as the constantly changing state of physical interactions between the oocyte and its
      companion somatic cells during folliculogenesis. Thus, the investigators study aimed to
      determine if there is any relationship between different gonadotropin preparations and
      oocyte-secreted factor secretion, the endocrine pattern in follicular fluid, and the
      apoptotic rate in cumulus cells during controlled ovarian stimulation.
    

Detailed description: 
      The follicular environment is primarily influenced by the type of gonadotropin the follicle
      is exposed to during the follicular phase. The role of gonadotropins has been especially
      important in improving the efficiency of in vitro fertilization. Several studies comparing
      the use of human menopausal gonadotropin (hMG) with recombinant follicle-stimulating hormone
      (rFSH) have found significant differences in the endocrinological profile and the follicular
      dynamics. These differences have been related to the human chorionic gonadotropin
      (hCG)-driven luteinizing hormone (LH) activity added to hMG. Moreover, differences in the
      proportion of acid residues in FSH molecules should be considered.

      On the other hand, the main physiological regulatory hormones of follicular survival are the
      gonadotropins. Suppression of serum gonadotropins leads to massive apoptosis of granulosa
      cells in developing follicles resulting in atresia; whereas, gonadotropin treatment of early
      antral and pre-ovulatory follicles prevents this unplanned apoptosis. However, studies using
      cultured rat granulosa cells have shown that treatments with FSH or LH/hCG are ineffective in
      preventing spontaneous apoptosis, suggesting neighboring theca cells and local factors
      produced in the ovary are important for regulation of follicle growth and atresia.
    

Intervention name(s): recombinant FSH; Urinary FSH; hMG
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Controlled ovarian stimulation with 150-300 UI recombinant FSH; Controlled ovarian stimulation with 150-300 UI urinary FSH; Controlled ovarian stimulation with 150-300 UI hMG
Other intervention name(s): Gonal-F; Fostipur; hMG-Lepori
Intervention MeSH terms: Menotropins
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: GDF-9; BMP-15; Steroids; Apoptosis rate; Endocrinology
Prevalence of Impaired Glucose Tolerance (IGT) in Patients With Frozen Shoulder
Condition: Frozen Shoulder; Impairment Glucose Tolerance
MeSH terms: Bursitis
Study type: Observational

Summary: 
      Idiopathic Adhesive Capsulitis, Frozen Shoulder is a condition in which there is a limitation
      and significant pain at the shoulder and it is increases with shoulder movements. The causes
      are not clear. The prevalence of this condition is four times higher in diabetic patient
      compare to the general population.

      The relation between frozen shoulder and impaired glucose tolerance remain unclear.

      Our hypothesis is that patients with no diabetes and that suffer from frozen shoulder have a
      higher prevalence of impaired glucose tolerance than the general population age matched.
    


Observational model: Case-Crossover
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        people that were diagnosed with frozen shoulder at the last three years and are not
        diabetic.
Ultrasound Assessment of DILAPAN-S
Condition: Cervical Dilation; Induction of Labor; Ultrasound Evaluation
MeSH terms: Dilatation, Pathologic
Study type: Observational

Summary: 
      The goal of this observational prospective study is to assess the change in Dilapan-S rod
      diameters using transvaginal ultrasound over a period of 12 hours in term women undergoing
      induction of labor.
    

Detailed description: 
      On admission for induction, study participants assigned to each group underwent continuous
      cardiotocography for 20 minutes prior to placement of the Dilapan-S rods (rod size: 4 x
      65mm). Placement of the Dilapan-S rods was limited to three physicians with the majority
      placed by the primary investigator. Placement was completed in a sterile manner under direct
      visualization and in accordance with the manufacturer's guidelines. The number of rods placed
      varied per individual and was based on the discretion of the physician. Each participant
      allocated to the Dilapan-S with saturated gauze group received placement of one, 4x4 inch
      gauze saturated with 10 cc of normal saline and placed at the level of the external os.
      Immediately after placement of the Dilapan-S rods, the study participant was asked to
      complete a patient satisfaction survey.

      Pre-specified transvaginal ultrasound assessment was performed at hours 3, 6, 8, and 12 post
      Dilapan-S placement using a GE Voluson E10 machine with a transvaginal GE RIC 5-9D
      transducer. Performance of the ultrasound evaluation was limited to the primary investigator
      and two co-authors of the study. After completion of the 12-hour ultrasound, the Dilapan-S
      rods and gauze, if used, were removed as per the manufacturer's instructions. The participant
      was then asked to complete a post Dilapan-S patient satisfaction survey.
    

Intervention name(s): Gauze; No gauze
Intervention type(s): Other; Other
Intervention description(s): placement of gauze; no gauze
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Pregnant individuals at term undergoing labor induction at single academic institution.
Scapular Kinematics of Young Swimmers
Condition: Scapula Injuries
Study type: Observational

Summary: 
      The aim of this study was to (a) compare the scapular kinematics of asymptomatic swimmers and
      healthy non-athletes and to (b) compare the scapular kinematics of the dominant and
      non-dominant shoulders in asymptomatic young swimmers.
    

Detailed description: 
      This cross-sectional study included 27 volunteered asymptomatic young swimmers (mean age:
      12.7 yrs) with at least 3 years of experience in a professional swimming club and 22 healthy
      non-athletes (mean age: 11.5 yrs). 3D scapular kinematics were evaluated at 0°, 30º, 60º,
      90º, and 120º with the electromagnetic tracking system during bilateral arm elevation and
      lowering on the scapular plane. The differences in the scapular kinematics of the dominant
      and the non-dominant side in both groups were analyzed with 2 by 8 Mixed Model ANOVA.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        This cross-sectional study included volunteer young swimmers with at least 3 years of
        experience in a professional swimming club and healthy non-athletes participants. The
        swimmer training program includes swimming training 6 days a week (10 hours in total), and
        3 land training (3 hours in total) including a general strengthening program (strength of
        the posterior shoulder musculature, core, squats, pull-ups, etc.) and stretching the
        anterior shoulder musculature.
      
Keywords: swimmers; scapula; kinematic; motion asymmetries; three dimensional