Donor Peripheral Stem Cell Transplant in Treating Patients With Hematolymphoid Malignancies
Condition: Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Nasal Type Extranodal NK/T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Relapsing Chronic Myelogenous Leukemia; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia
MeSH terms: Burkitt Lymphoma; Mycoses; Lymphoma; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, B-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Hodgkin Disease; Lymphoma, Mantle-Cell; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Lymphoma, B-Cell, Marginal Zone; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Plasmablastic Lymphoma; Mycosis Fungoides; Sezary Syndrome; Leukemia, T-Cell; Lymphoma, T-Cell, Cutaneous; Waldenstrom Macroglobulinemia; Leukemia-Lymphoma, Adult T-Cell; Lymphomatoid Granulomatosis; Lymphoma, Extranodal NK-T-Cell; Intraocular Lymphoma; Recurrence
Study type: Interventional
Phase: Phase 1

Summary: 
      This phase 1 trial studies the side effects and the best dose of donor CD8+ memory T-cells in
      treating patients with hematolymphoid malignancies. Giving low dose of chemotherapy before a
      donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It may
      also stop the patient's immune system from rejecting the donor's stem cells. The donated stem
      cells may replace the patient's immune cells and help destroy any remaining cancer cells
      (graft-versus-cancer effects). Giving an infusion of the donor's T cells (donor lymphocyte
      infusion) after the transplant may help increase this effect
    

Detailed description: 
      PRIMARY OBJECTIVES:

      I. To determine the feasibility of purifying allogeneic CD8+ memory T-cells suitable for
      clinical application and to determine the safety and maximum tolerated dose (MTD) of these
      cells in patients with recurrent or refractory hematolymphoid malignancies following
      allogeneic hematopoietic cell transplant (HCT).

      SECONDARY OBJECTIVES:

      I. To determine disease response, time to disease progression, event-free survival, and
      overall survival following treatment with allogeneic CD8+ memory T-cells.

      II. To assess donor specific chimerism before and at designated time points after treatment
      with allogeneic CD8+ memory T-cells.

      OUTLINE: This is a dose-escalation study.

      Patients undergo CD8+ memory T-cell infusion over 10 to 20 minutes.
    

Intervention name(s): therapeutic allogeneic lymphocytes
Intervention type(s): Biological
Intervention description(s): Undergo CD8 memory T-cell infusion
Other intervention name(s): ALLOLYMPH
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment