Influence of Daily Activities on Retinal Microcirculation
Condition: Retinal Microcirculation Disorder
Study type: Interventional

Summary: 
      The daily behaviors such as drinking coffee, wine, reading, exercise and body postural
      changes may have influence on the function or morphology of the retinal microcirculation in
      healthy people.A recent study found that the fingertips microvascular bed constricted
      obviously after the intake of a cup of coffee with caffeine, it significantly reduced blood
      flow to the fingers; Long reading of electronic products can induce significant dry eye
      symptoms, affect visual quality, and cause asthenopia. Microcirculation is critical for
      regulating vascular resistance and blood flow in organs. Fundus blood vessels is the only
      visible microvascular in vivo, its morphology and function changes not only associated with
      eye disease, but also with cardiovascular and cerebrovascular diseases. Optical coherence
      tomography angiography (OCTA) is a new technique which could acquire blood flow information
      in a non-invasive way without the use of dye. Magnetic resonance imaging (MRI) can
      quantitatively evaluation of cerebral blood flow and retina-choroid blood flow using the
      noninvasive arterial spin labeling technique in a large field of view (FOV) without depth
      limitations.The study tried to detect the influence of daily behaviors such as drinking
      coffee, red wine, reading ,and exercise on the retinal microcirculation with OCTA and MRI,
      and provide reference for health behaviors.
    


Intervention name(s): Beverage consumption; Daily reading; Body motion
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): The participants drink 300ml wine (alcohol concentration:12.5%)or 300ml coffee (caffeine concentration 72 mg), or water.; Reading paper books, playing video games with mobile phones, or non-reading for 8 hours.; Exercise or body postural changes
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Influence of beverage consumption 30 participants drink coffee, red wine, and water respectively on three mornings interval with a one-week washout period. Each period lasts 2 hours. OCTA and MRI scanning are taken every 30 minutes, and venous blood was collected before MRI scanning.
Influence of daily reading 30 participants read paper books, play video games with mobile phones, and non-read respectively on three mornings interval with a one-week washout period. Each period lasts 8 hours. OCTA and MRI scanning are taken every 2 hours.
Influence of body motion (exercise and body postural changes) Exercise: 30 participants will be enrolled. Participants undergo to jogging for 10 minutes, 30 minutes, and 1 hour respectively on three mornings interval with a 3-day washout period. OCTA and MRI scanning are taken before and after jogging.
Body postural changes: 30 participants will be enrolled. OCTA and MRI scanning are taken before and after body postural changes.
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Beverage consumption; Reading; Body motion; Retinal microcirculation; Optical coherence tomography angiography; Magnetic resonance imaging