bioihbjkbjnl/mcl2 huggingface dataset:
The Relation of Ankle Mobility and Achilles Tendon, Plantar Fascia and Iliotibial Band Mechanical Properties
Condition: Mobility Limitation; Stiffness of Right Ankle, Not Elsewhere Classified; Stiffness of Left Ankle, Not Elsewhere Classified; Tone Increased, Muscle
MeSH terms: Muscle Hypertonia; Mobility Limitation
Study type: Interventional

Summary: 
      The myotonometric assessment is becoming popular and important in athletic population. It is
      mentioned an alternate method than expensive methods, and it is easy and reliable assessment.
      Still there is not enough information of mechanical characteristics in athletic population
      and ankle mobility. Most clinicians or trainers can use this results and technique for
      enhancing performance, rehabilitation or prevention
    

Detailed description: 
      The soft tissue mechanical properties can be assessed through elastography and
      ultrasonography. Both methods can measure passive and active soft tissue properties. These
      methods are the gold standard to measure stiffness and elasticity, but they are expensive,
      operator dependent and need a laboratory settings.Recently, myotonometric device has been
      used to measure the mechanical properties of the muscles and tendons. This method serves many
      advantages, such as non-invasive, painless and cost-effective. There is an increasing
      literature on athletic training about how training effects viscoelastic properties. However,
      to the best of our knowledge, there were no studies assessing stiffness and elasticity of AT,
      PF and ITB and the relation with ankle mobility in different sport disciplines. The purpose
      of this study were to demonstrate the mechanical properties of AT, PF and ITB and find out
      relation with restricted ankle mobility in athletes.
    

Intervention name(s): myotonometric assessment; Ankle mobility assessment
Intervention type(s): Diagnostic Test; Diagnostic Test
Intervention description(s): The measurement method of the device is based on the free oscillation technique. Firstly, the probe of the device is placed perpendicular to the skin and a pre-pressure is applied to compress the subcutaneous tissue. Then, a short mechanical impulse is applied, causing damped oscillation on the tissue and the co-oscillation is recorded by an accelerometer.; The knee to wall lunge test will use in a standing position while the heel in contact with the ground and the knee was in line with second toe. Athletes will do lunge forward and inclinometer will be place at the middle anterior tibial crista and measurement will be record.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Professional male athletes (basketballers, voleyballers, runners) will participate and divided to groups. AT, PF and ITB mechanical properties will evaluate with MyotonPro device (Myoton Ltd, Estonia). Ankle mobility will measure with inclinometer during a knee to wall lunge test.
Masking: Single (Outcomes Assessor)
Primary purpose: Diagnostic
Keywords: Stiffness; Tone; Elasticity; Ankle mobility
IV Iron Safety: Evaluation of Iron Species in Healthy Subjects
Condition: Anemia
Study type: Interventional
Phase: Phase 4

Summary: 
      An approved treatment for anemia or low blood count due to chronic kidney disease is IV
      (intravenous, given into the vein) injection of an iron treatment. IV iron increases iron in
      the blood. Many IV iron therapies are now available in both brand name and generic forms. One
      common IV iron product is sodium ferric gluconate (SFG) sold as brand name Ferrlecit.
      Recently, a generic version of Ferrlecit was approved but was felt to be possibly more toxic
      than the brand product. The purpose of this research project is to see if the brand and
      generic IV iron products produce the same amount of iron in the blood in healthy volunteers,
      including an iron form that more toxic than other iron forms.
    

Detailed description: 
      A generic version of Ferrlecit was approved in 2011 and is available. Shortly after the
      approval of the generic, a 'Reflections Paper on Non-Clinical Studies for Generic
      Nanoparticle Iron Medicinal Product Applications' was published by the European Medicines
      Agency. The authors of this paper proposed that generic iron preparations deliver increased
      levels of 'labile iron' to the plasma resulting in oxidative damage and toxicity. As such,
      studies measuring the in vivo levels of free or labile iron from generic versus brand
      iron-preparations were recommended.

      The primary outcome will be the assessment of non-inferiority of the generic colloid product
      against the reference colloid product with respect to non-transferrin bound iron (NTBI),
      after single-dose i.v. administration of brand and generic sodium ferric gluconate injections
      in n=48 healthy subjects.
    

Intervention name(s): Brand sodium ferric gluconate; Generic sodium ferric gluconate
Intervention type(s): Drug; Drug
Intervention description(s): brand product; generic product
Other intervention name(s): Ferrecit; generic iron
Intervention MeSH terms: Ferric gluconate; Ferric Compounds
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: iron; pharmacokinetics
Effects of Nitrous Oxide: A Dose-Response Analysis - 5
Condition: Opioid-Related Disorders; Substance-Related Disorders
MeSH terms: Substance-Related Disorders; Opioid-Related Disorders
Study type: Interventional

Summary: 
      The purpose of this study is to conduct experiments to examine subjective and reinforcing
      effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug
      abusers and preference procedures will be used to assess reinforcing effects. To examine the
      subjective, psychomotor, and reinforcing effects of nitrous oxide in healthy volunteers. This
      is a dose-response analysis.
    


Intervention name(s): 10% N2O; 20% N2O; 30% N2O; 40% N2O
Intervention type(s): Drug; Drug; Drug; Drug
Intervention MeSH terms: Nitrous Oxide
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Keywords: nitrous oxide; inhalant; subjective effects; healthy volunteer
Quality of Recovery From Obstetric Anaesthesia - a Multicentre Study
Condition: Obstetric Anesthesia Problems; Anesthesia Morbidity; Quality of Life
Study type: Observational

Summary: 
      Quality of recovery is an important outcome measure in anaesthesia, whilst there are
      validated tools for this in surgery and regional anesthesia there are no fully validated
      tools for obstetrics anaesthesia. The aim of this study is to use the Obstetric Quality of
      Recovery (ObsQoR) score across multiple centres to assess correlation to length of stay and
      variation for different types of operative and non- operative delivery.
    

Detailed description: 
      An observational survey based study, for 3 consecutive week days, chosen by the local
      investigating team during a two-week period across multiple centres.

        -  Local investigators will complete the survey with each patient who has received
           anaesthetic intervention from an anaesthetist, 1 day, around 24hrs after delivery in
           line with their routine anaesthetic follow up.

        -  At 30 days, a telephone survey will be conducted with each patient to repeat the ObsQoR
           survey and ask key questions regarding functional recovery and activities of daily
           living post delivery.

      In addition for a small number of sites, elective caesarean delivery patients will have blood
      taken at the point of anaesthesia and 24 hours post delivery to assess the immune function
      and any changes which may predict poorer outcome in these women.
    

Intervention name(s): Survey
Intervention type(s): Other
Intervention description(s): A survey will be used at 24 hours and 30 days to assess the quality of recovery
Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Peripartum women during the designated study period who have received anaesthetic
        intervention in the previous 24-hour period for 3 consecutive days.
      
Biospecimen description: 
      Samples will be taken from selected Caesarean Delivery Patients before and after delivery to
      analyse to assess immune profiles.
Hepatocellular Carcinoma Treated With Iodine-125 Implantation
Condition: Liver Carcinoma
MeSH terms: Carcinoma; Carcinoma, Hepatocellular
Study type: Interventional
Phase: Phase 3

Summary: 
      To prospectively evaluate whether use of combined radiofrequency ablation (RFA) and
      percutaneous iodine-125 (125I) seeds implantation results in better survival compared with
      use of RFA alone in patients with hepatocellular carcinoma.
    

Detailed description: 
      This study was local ethical committee approved; all patients gave written informed consent.
      A total of 136 patients were randomly assigned to undergo RFA-125I (n = 68; 42 men, 26 women;
      mean age, 50.7 years; age range, 29-73 years) or RFA alone (n = 68; 47 men, 21 women; mean
      age, 48.9 years; age range, 30-74 years). Patients with viable tumors at computed tomography
      (CT) 4 weeks after treatment received additional treatment. Rates of local tumor progression
      and overall survival were evaluated by using Kaplan-Meier and log-rank tests, respectively.
      The relative prognostic significance of variables in predicting overall survival and the time
      to tumor recurrence or metastasis were assessed with multivariate Cox proportional hazards
      regression and logistic regression analyses, respectively.
    

Intervention name(s): Radiofrequency Ablation; iodine
Intervention type(s): Procedure; Radiation
Intervention description(s): For RFA, we used a commercially available system (RF 2000; Radio Therapeutics, Mountain View, Calif) and a needle electrode with a 15-gauge insulated cannula that had 10 hook-shaped expandable electrode tines with a diameter of 3.5 cm at expansion (LeVeen; Radio Therapeutics).The radioactivity per seed ranged from 0.5 to 0.6 millicuries (mCi); The 125I seeds (0.8 mm in diameter and 4.5mm in length) were enclosed in a NiTinol capsule (China Institute of Atomic Energy, Beijing). These seeds could produce 27.4-31.5 keV X-ray and 35.5 Kev γ ray, with a half-life of 59.6 days. The radioactivity per seed ranged from 0.5 to 0.6 millicuries (mCi).
Other intervention name(s): Radio Therapeutics, Mountain View, Calif; iodine-125 seed
Intervention MeSH terms: Iodine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: HCC, RFA, Iodine-125, Recurrence
Study of ST266 Given by Intranasal Delivery in Glaucoma Suspect Subjects
Condition: Ocular Hypertension
MeSH terms: Glaucoma; Ocular Hypertension
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of this trial is to assess the safety of ST266 given by non-invasive
      intranasal trans-cribriform delivery to glaucoma suspect subjects with ocular hypertension,
      optic nerve cupping, or family history of glaucoma.
    

Detailed description: 
      This clinical trial is a dose escalating design in three (3) cohorts. In the first cohort,
      subjects will be treated with ST266 delivered using a non-invasive trans-cribriform
      intranasal delivery device daily for 14 days, in alternating single nostrils. If there are no
      SAEs and no pattern of concern in the AE's, the Investigator may proceed to the second
      cohort. In Cohort Two, subjects will be administered ST266 to each nostril daily for 14 days.
      As with the first cohort, if there are no safety concerns, the investigator may move on to
      the third cohort. In Cohort Three, subjects will be administered ST266 to each nostril daily
      for 28 days. All subjects will be followed for 12 months after the last dose of study drug.
      ST266 will be administered by a health care professional trained to deliver ST266
      intranasally. No efficacy data will be collected.
    

Intervention name(s): ST266 via Intranasal Delivery
Intervention type(s): Combination Product
Intervention description(s): ST266 administered by non-invasive trans-cribriform intranasal delivery using the SipNose intranasal device.
Allocation: Non-Randomized
Intervention model: Sequential Assignment
Intervention model description: This clinical trial is a dose escalating design in three (3) cohorts of three (3) subjects per Cohort. In the first cohort, subjects will be administered ST266, delivered intranasally, at a dose of two hundred microliters (200 µL) daily for 14 days, in alternating single nostrils. After 14 daily treatments there is a seven (7)-day follow-up period. If there are no SAEs and no pattern of concern in the AE's, the Investigator may proceed to the second cohort of three (3) subjects. In Cohort Two, three (3) subjects will be administered 200 µL to each nostril daily (400 µL total per day) for 14 days. There will be a seven (7)-day follow-up. Like Cohort One, if there are no safety concerns, the investigator may move on to the third cohort of three (3) subjects. In Cohort Three, three (3) subjects will be administered 200 µL to each nostril daily (400 µL total per day) for 28 days.
Masking: None (Open Label)
Primary purpose: Treatment
Shape Up Kids Fitness Ancillary
Condition: Childhood Obesity
MeSH terms: Pediatric Obesity
Study type: Observational

Summary: 
      The overall objective of this study is to quantify the decision-making process and underlying
      biases around leisure activity behaviors using the Activity Preference Assessment (APA), a
      novel psychological task. The investigators plan to validate the APA against objectively
      measured sedentary and physical activity time, and examine its potential to predict
      health-related outcomes in children and adolescents. The Shape Up Kids Fitness Ancillary
      protocol will add exercise testing, cognitive and behavioral measures, accelerometry, and
      questionnaires to the existing Shape Up Kids primary study dataset.
    

Detailed description: 
      The investigators will enroll 60 boys and girls (50% female) between the ages of 8-17 years
      into this pilot and feasibility ancillary study. The aims of this study are to validate and
      test the reliability of the Activity Preference Assessment (APA), as described below.

      Aim 1: To examine the convergent validity of the APA against habitual physical and sedentary
      activity time measured objectively by seven days of accelerometry, as well as leisure
      activity choices during a 30-minute free-choice play period.

      Aim 2: To examine the criterion validity of the APA against concurrent measures of body
      composition, cardiometabolic health indicators, aerobic fitness, and physical strength.

      Aim 3: To measure the test-retest reliability of APA outcomes through repeated measures
      separated by approximately one week.

      Exploratory Aim: To investigate patterns or clusters of activity preferences through
      exploratory factor analysis of activity liking VAS scores.
    

Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        This study will identify and recruit 60 participants from the Shape Up Kids primary study
        sample of 360 participants. Ancillary participants will be between the ages of 8-17 years.
        We will have an even distribution of boys (n=30) and girls (n=30) and aim to have a
        representative distribution of race.
      
Keywords: Cardiorespiratory fitness; Sedentary behavior; Physical activity; Decision-making; Cardiometabolic risk factors
Perioperative Transfusion Related Outcome
Condition: Blood Transfusion
Study type: Observational

Summary: 
      A secondary analysis of the Turkish National Perioperative Transfusion Study (TULIP TS)
      database will be performed.
    

Detailed description: 
      The Turkish National Perioperative Transfusion Study (TULIP TS) was conducted by The Turkish
      Society of Anesthesiologists' Multicentre Clinical Trials Network.

      TULIP TS included 6481 patients undergoing major elective surgery, from 61 study sites across
      the country.

      Transfusion practices of clinicians working at diverse surgical fields; differences between
      current transfusion practices and patient blood management strategies; the areas for
      improvement and the obstacles that could prevent change were evaluated and identified.

      Data relevant to perioperative transfusion rates of red blood cells, fresh frozen plasma and
      platelets, the indications for transfusion and postoperative adverse outcomes including 1
      month all cause mortality was obtained.

      The TULIP TS group aims to collect further data concerning 1 year all cause mortality of the
      same patient population and to evaluate adverse outcomes in transfused and non transfused
      patients.
    

Intervention name(s): Blood transfusion; Control
Intervention type(s): Other; Other
Intervention description(s): Patients who received blood transfusion in the perioperative period; Patients who did not receive blood transfusion in the perioperative period
Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients undergoing major elective surgery in General surgery Orthopedics Urology
        Transplantation surgery Neurosurgery Gynecology and obstetrics Cardiovascular surgery
      
Keywords: Surgery; Perioperative; Transfusion; Mortality
Investigation of Predictors of Typing Performance in Office Employees With Neck Pain
Condition: Task Performance and Analysis
MeSH terms: Neck Pain
Study type: Observational

Summary: 
      Determining the predictors that are effective on work performance and preventive approaches
      to be developed for these predictors must be individual and adaptable to every environment,
      time, and equipment. In this context, the purpose of the present study was to show the
      relations between neck disability, Upper Trapezius (UT) muscle activation, posture, and
      demographic characteristics with typing task performance in office employees who have neck
      pain by using their equipment in their workplaces.
    

Detailed description: 
      The present study was conducted to show the relations between neck disability, UT muscle
      activation, posture, and demographic characteristics with typing task performance in office
      employees who have neck pain by using their equipment in their workplaces. We hypothesized
      that UT muscle activation, working posture, and age might be the main predictors of typing
      performance in office employees with neck pain. For this purpose, full-time office employees
      who use computers for at least 3 hours a day and have neck pain were invited to the study.
      Volunteers without any health concern, upper-body injury, and surgery provided informed,
      written consent to participate in the study.

      The participants were given a 10-minute typing task in their working environments, during
      which right and left UT muscle activation was recorded with Surface Electromyography (sEMG).
      Work posture was evaluated with Rapid Upper Limb Assessment (RULA) and Forward Head Posture
      (FHP) was evaluated with Cervical Range of Motion (CROM) Device. Hierarchical Regression
      Analysis was conducted to examine the predictors of typing performance.
    

Intervention name(s): There will be no interventions.
Intervention type(s): Other
Intervention description(s): Measurements and performance tests were conducted to investigate predictors of work-related performance
Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Office workers with neck pain, the sample of the study, were selected from among the people
        living in Istanbul with the invitation to volunteer.
      
Keywords: Neck Pain; Office Employees; Task- Specific Performance; Surface Electromyography; Trapezius Muscle; Forward Head Posture; Posture
The Effectiveness of Parent-Child Interaction Therapy (PCIT)
Condition: Behavior Problems; Oppositional Defiant Disorder; Conduct Disorder
MeSH terms: Problem Behavior; Conduct Disorder; Attention Deficit and Disruptive Behavior Disorders
Study type: Interventional

Summary: 
      The purpose of this study was to investigate whether a type of parent-based intervention,
      Parent-Child Interaction Therapy will lower symptoms of behavior problems in young children
      more than treatment as usual.
    

Detailed description: 
      Behaviour problems, i.e. symptoms of oppositional defiant disorder (ODD) and conduct disorder
      (CD) are among the prevalent psychiatric disorders in children and one of the leading causes
      of help-seeking for mental health problems in children. There are several efficacious
      treatments for such problems in young children. However, most of these require that parents
      meet in groups. This is not always feasible. It is therefore a need to develop treatments
      that can deal with parents and families individually. Parent-Child Interaction Therapy (PCIT)
      is such an individually based treatment. Efficacy studies indicate symptom reduction greater
      that in treatment as usual (TAU). However, there is a need to study its effectiveness in
      ordinary clinical practise. This trial will study its effect in ordinary psychiatric clinics
      in the middle of Norway and compare it to the regular treatment (TAU) provided to young
      children with behavior problems in these clinics.
    

Intervention name(s): Parent-Child Interaction Therapy; TAU
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Parents will be trained in interaction with their children in ways which foster non-hostility and cooperation in their children. By means of an ear-plug they will receive instruction on how to play and set limits for their child from their therapist who watches the interaction through a one-way mirror. Treatment is given until the parent masters these skill, which commonly takes 15-20 session of 1 hour.; Usual treatment for behavioral disorders
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Behavior problems; Parent-Child Interaction; Locus of control; Psychiatric symptoms; Depressive symptoms; Attachment