Efficacy of the Use of Silver Diamine Fluoride and Sodium Fluoride Varnish for the Treatment of Caries in Children
Condition: Dental Caries in Children
MeSH terms: Dental Caries
Study type: Observational

Summary: 
      The goal of this observational study is to identify the efficacy of silver diamine fluoride
      38% followed by sodium fluoride varnish 5% in a population with untreated dental caries age
      range 4 to 12 years old. The main questions to answer are

        -  Efficacy of treatment of active tooth decay with the treatment protocol of 38% silver
           diamine fluoride and 5% sodium fluoride varnish.

        -  Clinical evaluation of tooth decay treated with 38% silver diamine fluoride and 5%
           sodium fluoride varnish in quality of hardness, color change and caries progression.

        -  Explore the association of treatment with 38% silver diamine fluoride and 5% sodium
           fluoride varnish with: i. Reduction of oral pain caused by the presence of carious
           lesions. ii. Improvement in gingival oral health. iii. Changes in general nutritional
           status through measurements of height, weight, hemoglobin levels and nutritional survey.
           The participants will be identified, charted (with nutritional surveys and parameters),
           as well as treated and compared in a six- and twelve-month period, where researchers
           will clinically identify the association between the use of this protocol and the
           efficacy of such, as well as other related nutritional aspects.
    


Intervention name(s): Silver diamine fluoride 38% followed by Sodium fluoride varnish 5%
Intervention type(s): Combination Product
Intervention description(s): 1)Completely drying of the affected area 2)10 microliters of silver diamine fluoride 38% (CaviGuard®) will be placed on the affected area 3)The affected area should be immediately covered with 20 microliters of fluoride varnish 5% (CaviGuard®) 4)Repeat steps 1-3 one or two more times for large caries at intervals of at least 2 days apart 5)Follow up evaluation of treatment success visits will be conducted at 6 and 12 months from the initial treatment.
NOTE: This is a single intervention using the device registered as Caviguard® to apply both products (Silver diamine fluoride 38% followed by Sodium fluoride varnish 5% (®)) in sequence.
Other intervention name(s): CaviGuard®, Silver Diamine Fluoride (SDF)
Intervention MeSH terms: Listerine; Fluorides; Sodium Fluoride; Fluorides, Topical
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        This study will be carried out in the city of Cochabamba, Bolivia, specifically at the
        Bolivian Food Bank Foundation located on Calle Francisco Prada between Aurelio Melean and
        J. Arauco 1120, from November 2022 to November 2023. This is a prospective cohort with a
        single assignment group (children aged 4 to 12 years) where a sample of 100-150 patients
        will be evaluated before, during and after their treatment.
      
Keywords: Oral Health; Dental Caries; Silver Diamine Fluoride; Caries in Children; CaviGuard®