bioihbjkbjnl/mcl2 huggingface dataset:
Comparative Study of Phototherapy for Hyperbilirubinemia
Condition: Hyperbilirubinemia
MeSH terms: Hyperbilirubinemia
Study type: Interventional

Summary: 
      Hyperbilirubinemia is a common problem for term and preterm newborns in intensive care
      nurseries around the world. It is a condition in which there is too much bilirubin in the
      blood. Bilirubin is a substance that is naturally released when red blood cells break down.
      In the early newborn period, multiple factors lead to an abnormally elevated bilirubin level.
      Large amounts of bilirubin can circulate to tissues in the brain and may cause seizures or
      brain damage. About 6.1% of term newborns and a higher percentage of preterm newborns develop
      hyperbilirubinemia that requires treatment. Initiating treatment depends on many factors,
      including the cause of the hyperbilirubinemia, the level of serum indirect bilirubin, the
      rate of indirect bilirubin rise, and the age of the patient. The goal of treatment is to keep
      the level of bilirubin from rising to dangerous levels.

      The bilirubin molecule absorbs light. Therefore, treatment of hyperbilirubinemia involves
      exposure of the baby's skin to special blue spectrum light. Phototherapy is globally
      recognized as the standard of care for treatment of elevated indirect hyperbilirubinemia in
      the neonatal period. This light exposure converts water-insoluble indirect bilirubin to a
      more easily excreted soluble molecule. Over the last five years, several devices have been
      introduced that emit high intensity light in the blue portion of the visible light spectrum.
      However, despite frequent use of such therapy, the effectiveness of different phototherapy
      devices has not been adequately compared. The objective of this study is to compare the
      efficacy of the blue LED fiberoptic phototherapy with the metal halide spot phototherapy
      versus blue LED bank light phototherapy versus a combination of tandem therapy on lowering to
      total serum bilirubin.
    


Intervention name(s): LED fiberoptic blanket phototherapy (BiliSoft blue LED fiberoptic blanket phototherapy); Metal halide phototherapy (Spot PT metal halide phototherapy); LED bank phototherapy (Natus neoBlue LED bank phototherapy); Metal halide plus LED fiberoptic blanket phototherapy (BiliSoft and Spot PT)
Intervention type(s): Device; Device; Device; Device
Intervention description(s): 35-50 mW/cm2/nm; 29.3-57.6 mW/cm2/nm; 12-35 mW/cm2/nm; 29.3-57.6 mW/cm2/nm and 35-50 mW/cm2/nm
Other intervention name(s): BiliSoft blue LED fiberoptic blanket phototherapy; Spot PT metal halide phototherapy; Natus neoBlue LED bank phototherapy; BiliSoft and Spot PT
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Assessment of Orality Disorders in Children With Food Allergies
Condition: Food Allergy in Children; 6 Years Old Maximum
MeSH terms: Hypersensitivity; Food Hypersensitivity
Study type: Interventional

Summary: 
      Orality disorders are frequent in child. There are complications like growth and psychomotor
      development disorders.

      The aim is to estimate the prevalence of orality disorder for child with one or several food
      allergy.
    


Intervention name(s): completion of questionnaire
Intervention type(s): Other
Intervention description(s): parents have to complete 2 questionnaires: demographic questionnaire and Montréal questionnaire when they come on allergy consultation.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Mechanisms of Orthopnea in Stable Obese Patients
Condition: Obesity
MeSH terms: Dyspnea
Study type: Interventional

Summary: 
      The purpose of this study is to study the role of closing volume as a determinant of
      orthopnea in stable obese subjects. The investigators hypothesized that: (1) increase in
      closing volume in supine position would be greater in orthopneic than in non-orthopneic
      subjects, and (2) the relationship of change in closing volume to change in dyspnea with
      position would be dependent on expiratory flow limitation in the sitting position.

      In stable obese subjects, in sitting and supine positions, the investigators measured Borg
      dyspnea score, static lung volumes, expiratory flow limitation, and single-breath nitrogen
      expiration test, from which the investigators determined closing volume and closing capacity,
      slope of phase III, and opening capacity.

      Orthopnea was defined as any increase in the Borg score in the supine position from its value
      in the sitting position
    


Intervention name(s): Supine
Intervention type(s): Other
Intervention description(s): measurements after 30 minutes in complete supine position
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: closing volume; expiratory flow limitation; obesity; orthopnea
A Study of Zevalin and Simultaneous Application of BEAM High-dose Chemotherapy Followed by Autologous Stem Cell Transplantation in Refractory and Relapsed Aggressive Non-Hodgkin Lymphomas
Condition: Primary Non-Hodgkin-Lymphoma; Refractory Non-Hodgkin-Lymphoma; CD20+ Aggressive Non-Hodgkin's Lymphoma
MeSH terms: Lymphoma; Lymphoma, Non-Hodgkin; Aggression
Study type: Interventional
Phase: Phase 2

Summary: 
      Phase II Study Concomitant High-Dose Radio-Immuno- and Chemotherapy with simultaneous
      application of Zevalin and BEAM followed by autologous peripheral stem cell transplantation
      in relapsed and refractory CD 20+ Non-Hodgkin's lymphoma
    


Intervention name(s): Zevalin
Intervention type(s): Drug
Intervention description(s): All applications of 90Y-Ibritumomab-Tiuxetan will be preceded by rituximab infusions at a dose of 250 mg/m2 at days -21 and day -14 (DL1) or day -12 (DL2) or day -10 (DL3-5), respectively.
High dose therapy will be given as BEAM
Other intervention name(s): 90Y-Ibritumomab-Tiuxetan
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: High-Dose Radio-Immuno- and Chemotherapy; stem cell transplantation; 90Y-Ibritumomab-Tiuxetan
Epidemiologic Study of Hepatocellular Carcinoma in the US
Condition: Hepatocellular Carcinoma
MeSH terms: Carcinoma; Carcinoma, Hepatocellular
Study type: Observational

Summary: 
      The purpose of this study is:

        -  to investigate the risk factors of HCC among Americans with focus on lifestyle factors
           and energy balance.

        -  to identify single nucleotide polymorphisms (SNPs) and haplotypes that are associated
           with HCC risk through a genome-wide search.

        -  to assess if genetic susceptibility differs by hepatitis virus infection or lifestyle
           factors, and to explore if there are interplays or effect modifications between genetic
           factors and viral infection or lifestyle factors.
    


Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        All patients with Hepatocellular Carcinoma in New Jersey and Connecticut as well as
        selected patients in New York, Hawaii and northern California.

        Healthy volunteers will comprise a random sample of New Jersey and Connecticut residents as
        controls.
      
Biospecimen description: 
      saliva samples
    
Keywords: Hepatocellular Carcinoma
Irreversible Electroporation(IRE) For Unresectable Renal Tumors
Condition: Renal Tumor
MeSH terms: Kidney Neoplasms
Study type: Interventional

Summary: 
      The purpose of this study is to investigate the safety and efficacy of irreversible
      electroporation (IRE) for unresectable renal tumors.
    

Detailed description: 
      By enrolling patients with renal tumors adapted to enrolled criteria, this study will
      document for the first time the safety and the short and long term efficacy of percutaneous
      or intraoperative IRE for renal tumors .
    

Intervention name(s): irreversible electroporation
Intervention type(s): Procedure
Intervention description(s): Percutaneous (CT-guided and/or US-guided) or open IRE with voltage in level B for renal tumors
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: irreversible electroporation; renal tumor
Evaluation of Functional MRI and DTI (Imaging Techniques) in Children With Epilepsy and Focal Brain Lesions
Condition: Epilepsy
MeSH terms: Epilepsy
Study type: Interventional

Summary: 
      This study is being done to look at the relationship between brain structure and brain
      function in patients with epilepsy or focal brain lesions (abnormal areas) that require
      surgery. This study will look at an imaging technique called magnetic resonance imaging (MRI)
      for looking at the brain. Specifically, the study will look at functional MRI, which is an
      imaging technique that can map brain function by taking pictures of the brain as it performs
      different tasks such as reading, thinking, or moving a body part and diffusion tensor imaging
      (DTI), which will look at brain structure. These types of imaging may help us learn more
      about different areas of the brain and how those areas of the brain are used in children with
      epilepsy. We plan to study 30 children with epilepsy.
    


Intervention name(s): Functional MRI, Diffusion Tensor Imaging
Intervention type(s): Procedure
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: MRI, fMRI, Epilepsy, Pediatric
Apatinib Dose Titration in Advanced or Metastatic Gastric Cancer
Condition: Gastric Cancer
MeSH terms: Stomach Neoplasms
Study type: Interventional

Summary: 
      Apatinib dose titration in Advanced or Metastatic Gastric Cancer
    


Intervention name(s): Apatinib
Intervention type(s): Drug
Intervention MeSH terms: Apatinib
Intervention model: Single Group Assignment
Primary purpose: Treatment
Keywords: Gastric Cancer; Pharmacokinetics; Dose titration
School Intervention With Daily Physical Activity and Healthy Food for Students With an Intellectual Disability.
Condition: Weight Loss; Food Habits; Mental Retardation
MeSH terms: Intellectual Disability; Weight Loss
Study type: Interventional

Summary: 
      A whole of school intervention with daily physical activity and healthy food for students
      with intellectual disabilities. The aim is to provide plenty of concrete examples of healthy
      life style choices and using school personnel and peers as role models. This will presumably
      result in healthier weight, better fitness and not least in new familiar healthy habits.
    

Detailed description: 
      Youth with an intellectual disability are reported more sedentary and more often overweight
      than non intellectual disability youth. Cardio metabolic risk factors are observed more
      frequent and at an earlier age among young people with intellectual disability. The school
      reaches all students and they spend the main part of their day in the school milieu hence
      examples of healthy lifestyle can be provided there.

      This intervention increased physical activity with daily scheduled physical activity. At
      least one lesson each week was at the gym. Food provided in the school environment was
      considered from content of sugar and fat and ónly healthy food choices was available at
      school. This included all school activities, both in the school area and on school activities
      out in the community. It included home economic lessons as well as the school cafeterias
      supply and school lunch content.

      To increase vegetable intake a special designed plate was used for lunch according the "plate
      model". In addition, the plate model was one theme during art class.
    

Intervention name(s): Healthier, Smarter, Happier
Intervention type(s): Behavioral
Intervention description(s): Increased physical activity and decreased sugar and fat intake during school hours
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: learning disability; blood lipids; cardio metabolic risk factors; upper secondary school for learning disability students; adolescents; cardio respiratory fitness; absorptiometry photos
A Study of the Efficacy and Safety of ICA-17043 (With or Without Hydroxyurea) in Patients With Sickle Cell Anemia.
Condition: Sickle Cell Disease; Sickle Cell Anemia
MeSH terms: Anemia; Anemia, Sickle Cell
Study type: Interventional
Phase: Phase 2

Summary: 
      ICA-17043 is being developed for the chronic treatment of patients with sickle cell disease
      (SCD) in both adults and children. ICA-17043 is a potent and specific inhibitor of a channel
      in human red blood cells (RBCs) that blocks RBC dehydration. ICA-17043 is expected to inhibit
      RBC dehydration and thus should prevent or delay the sickling process. By reducing sickled
      cells, an improvement in anemia, a reduction in painful crises, and ultimately, less
      end-organ disease is anticipated.
    


Intervention name(s): Low Dose ICA-17043; High dose ICA-17043; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Low dose arm; 150 mg Loading Dose; 10 mg daily dose; Placebo Loading dose capsules and maintenance dose tablets matched 10 mg active treatment group
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: sickle cell anemia; sickle cell disease; anemia; ICA-17043; senicapoc
Acupuncture In Migraine Without Aura Patients
Condition: Migraine Without Aura; Acupuncture
MeSH terms: Migraine Disorders; Migraine without Aura
Study type: Interventional

Summary: 
      The investigators aimed to investigate the effect of acupuncture treatment on attack
      frequency, pain intensity, and disability in migraine without aura patients who receive
      prophylaxis treatment.
    

Detailed description: 
      Acupuncture is a Traditional Chinese Medicine method that has been used for 3000 years to
      control symptoms, treat illnesses, and relieve pain. Acupuncture is widely used in many
      countries today as a complementary therapy, especially in cases of chronic pain. Migraine is
      one of the diseases in which acupuncture treatment is commonly used. Studies conducted so far
      have focused more on the effect of acupuncture on pain intensity in patients with migraine.
      Data comparing the impact of acupuncture on both the attack frequency and disability in
      migraine are relatively scarce.
    

Intervention name(s): Acupuncture
Intervention type(s): Other
Intervention description(s): Acupuncture is a complementary therapy modality which is used by needle inserted the specific points on the body.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: migraine; acupuncture; MIDAS
The Effectiveness of a Mobile Application in Educating Partial Denture Wearers
Condition: Mobile Applications
Study type: Interventional

Summary: 
      A randomised control trial to evaluate the effect of a mobile application on partial denture
      wearers's dental knowledge, oral hygiene and denture hygiene. The null hypothesis of the
      study states that there will be no difference in dental knowledge, oral and denture hygiene
      among patients educated using the mobile application compared to those educated using the
      conventional method of verbal instructions accompanied by demonstrations on dental models.
    

Detailed description: 
      Partial denture wearers are at higher risk of developing caries and periodontal disease.
      Thus, providing oral and denture hygiene care instructions after denture delivery is crucial
      for prevention of oral diseases. A mobile application was developed using the progressive web
      application technology for chairside education and to serve as a reference material. The
      effect of the mobile application on patient's dental knowledge compared to the conventional
      method was evaluated using a knowledge questionnaire administered before and after education.
      The knowledge scores obtained were analysed using the Two-way mixed ANOVA test. Patients'
      oral hygiene was assessed by comparing the Silness and Loe Plaque Index and Gingival Index
      scores before and after education. Denture hygiene was evaluated by comparing the denture
      plaque score before and after education. Statistical analysis of the Plaque Index, Gingival
      Index and denture plaque score was done using Mann-Whitney U Test and Friedman Test.
    

Intervention name(s): 'Oral and Denture Guide' mobile application
Intervention type(s): Other
Intervention description(s): 'Oral and Denture Guide' mobile application provides evidence-based information about cleaning aids and material for dentures, denture care and oral hygiene instructions.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants are randomly allocated into the intervention group (educated using mobile application) and control group (educated using verbal instructions accompanied by demonstrations on dental models)
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: Progressive web application, Denture care, Oral Hygiene
PERFECT Project - Part 1 - Study 1
Condition: Diabetes Prevention; Obesity Prevention
Study type: Interventional

Summary: 
      The objectives are to test the acute effects of different extruded pulse snacks on: 1)
      post-prandial blood glucose, insulin and appetite for two hours, and 2) food intake two hours
      following consumption of pulse products.

      The investigators hypothesize that snack products containing pulse ingredients will lead to
      lower blood glucose, insulin, appetite and food intake responses compared to non-pulse snack
      products.
    


Intervention name(s): Control; Small particle size pea flour; Large particle size pea flour; Lentil flour; Navy bean flour; Pinto bean flour
Intervention type(s): Other; Other; Other; Other; Other; Other
Intervention description(s): Non pulse extruded snack; Pulse extruded snack; Pulse extruded snack; Pulse extruded snack; Pulse extruded snack; Pulse extruded snack
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
The Effect of Flexible Thoracolumbar Brace on Scoliosis in Cerebral Palsy
Condition: Cerebral Palsy
MeSH terms: Scoliosis; Paralysis; Cerebral Palsy
Study type: Interventional

Summary: 
      The Effect of Flexible Thoracolumbar Brace on Scoliosis in Cerebral Palsy, Prospective,
      Randomized, Open-label Trial
    


Intervention name(s): flexible thoracolumbar brace
Intervention type(s): Device
Intervention description(s): Subjects would wear the flexible thoracolumbar brace over 18 hours a day
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Cerebral palsy; Brace; Scoliosis
Full-arch Monolithic Zirconia ISFDP Follow up
Condition: Edentulous
MeSH terms: Mouth, Edentulous
Study type: Observational

Summary: 
      This study is designed to recall all patients who have received a full-arch monolithic
      zirconia implant supported fixed dental prosthesis in the University of North Carolina (UNC)
      School of Dentistry Graduate Prosthodontic and/or Dental Faculty Practice clinics between
      January 1, 2008 to September 1, 2015. The main purpose is to evaluate the biological and
      technical complications associated with this form of prosthetic treatment. Additionally
      patient centered outcomes will be evaluated.
    

Detailed description: 
      Purpose: A retrospective single-center study to provide scientific data on the clinical
      performance of full-arch monolithic zirconia implant supported fixed dental prosthesis
      (MZISFDP).

      Participants: Individuals with at least one edentulous dental arch (maxilla/mandible) who
      were treated in the UNC Graduate Prosthodontic clinic and Dental Faculty Practice between
      January 1, 2008 to September 1, 2015 with full-arch MZISFDP.

      Procedures (methods): This study is designed as a retrospective descriptive study with a
      single prospective examination of a population of subjects previously restored with full-arch
      MZISFDPs. An estimated 60 participants will be enrolled in the study. The study includes
      retrospective data and radiograph collection from dental records as well as data collection
      from one prospective visit that includes clinical examination, a panoramic radiograph and 2
      patient questionnaires.
    

Intervention name(s): Monolithic zirconia prosthesis
Intervention type(s): Device
Intervention description(s): Edentulous arch subjects treated with a monolithic zirconia implant supported fixed dental prosthesis.
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        All adult patients treated in the UNC School of Dentistry Graduate Prosthodontic and/or
        Dental Faculty Practice clinic(s) between January 1, 2008 to September 1, 2015 with at
        least one full-arch monolithic zirconia implant supported fixed dental prosthesis.
      
Keywords: Monolithic Zirconia; Implant supported prosthesis; Fixed partial denture
Sunscreens in Patients With Cutaneous Lupus Erythematosus(CLE)
Condition: Cutaneous Lupus Erythematosus
MeSH terms: Lupus Erythematosus, Systemic; Lupus Erythematosus, Cutaneous
Study type: Interventional

Summary: 
      Part I: to investigate the efficacy of different sunscreens in the prevention of skin lesions
      following standardized photoprovocation with Ultraviolet A/Ultraviolet B (UVA/UVB) light in
      patients with CLE.

      Part II: to evaluate the influence of different sunscreens on the expression of biomarkers in
      the skin of patients with CLE and of Healthy Controls following UV irradiation.
    

Detailed description: 
      Part I

      Part I-interventions will be:

        -  Experimental intervention: Application of broad-spectrum sunscreens with a low, medium,
           and high Sun Protection Factor (SPF) in random order to uninvolved skin areas prior to
           standardized photoprovocation.

        -  Control intervention: Intra-individual application of vehicle in random order;
           standardized photoprovocation of vehicle treated and untreated areas.

      Part II

      Part II-interventions will be:

        -  Experimental intervention: Application of a broad-spectrum sunscreen with a high SPF to
           uninvolved skin areas prior to UV irradiation.

        -  Control intervention: UV irradiation of untreated areas.
    

Intervention name(s): UV A and B irradiation
Intervention type(s): Other
Intervention description(s): UV irradiation
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Sunscreening Agents