Study of Single Platelet-Rich Plasma Local Injection Vs. Single Corticosteroid Local Injection in Carpal Tunnel Syndrome
Condition: Carpal Tunnel Syndrome
MeSH terms: Carpal Tunnel Syndrome; Syndrome
Study type: Interventional
Phase: Phase 4

Summary: 
      This clinical trial aims to evaluate the effect of a single local platelet-rich plasma
      injection Versus local steroid injection in treating mild idiopathic carpal tunnel syndrome
      regarding pain relief and function improvement and electrophysiological studies of the median
      nerve as a baseline and during a follow-up period of 3 months.

      The main question[s] it aims to answer are:

        -  Does platelet-rich plasma injection provide better pain relief for CTS symptoms than
           steroid injection?

        -  Does platelet-rich plasma improve parameters of median nerve conduction study than local
           steroid?

      Participants will have:

        -  A complete history and clinical examination, including sensory and motor examination and
           provocative tests for CTS.

        -  Visual analog scale (VAS), Symptom severity scale (SSS), and functional severity scale
           (FSS) of the Boston Carpal Tunnel Questionnaire (BCTQ) before local injection and three
           months after local injection by the same investigator.

        -  Nerve conduction studies (NCS) for median and ulnar nerves were carried out before local
           injection and three months after local injection by the same investigator.

      Researchers will compare the efficacy of a single PRP local injection compared to a single
      corticosteroid local injection for treating mild idiopathic CTS using nerve conduction
      studies (NCS), Visual Analog Scale (VAS), and Boston Carpal Tunnel Questionnaire (BCTQ) as
      objective and subjective outcome measures.
    

Detailed description: 
      Carpal tunnel syndrome (CTS) is the most known entrapment neuropathy. Diagnosis of CTS is
      clinical, which could be confirmed by nerve conduction study (NCS). Non-operative management
      is the first line of treatment, including splitting, antiinflammatory, and neurotonics.

      There is evidence of improvement in CTS after local corticosteroid injection, but
      complications are still recorded [5]. Platelet-rich plasma (PRP) is a novel, promising
      treatment providing growth factors for nerve regeneration and inflammation relief. This field
      needs further evaluation and analysis compared to traditional local steroid injection.
    

Intervention name(s): Local corticosteroid injection; Platelet-rich Plasma Local injection
Intervention type(s): Drug; Drug
Intervention description(s): Local corticosteroid injection;1 ml of triamcinolone acetonide 40 milligram/1.0 mL; Platelet-rich Plasma (From 2-step centrifugation of patient blood) Local injection.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A prospective, interventional, comparative double-blinded study.
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: Carpal Tunnel Syndrome; Corticosteroids; Platelet-Rich Plasma; Nerve Conduction Study; Boston Questionnaire; Visual Analogue Scale