Nicotine Influence on the Retina Following the Use of Electronic Cigarette
Condition: Electronic Cigarette Use; Retina; Change
Study type: Interventional

Summary: 
      The marketing of electronic cigarettes (e-cigarettes) in 2003 was initially intended to
      present a healthier alternative to smokers. Subsequently, it became an extremely widespread
      fashion phenomenon, especially among young people. It thus contributes to attracting new
      consumers thanks to its modern and technological presentation, combined with a panoply of
      captivating fragrances.

      In 2014, the FDA still does not recognize this practice as a substitute for smoking intended
      to limit it, and several recent studies have demonstrated the potential harmful effects of
      e-cigarettes on health. Indeed, the latter also have pulmonary effects reminiscent of those
      of the original cigarette, namely breathing difficulties or even lung inflammation.

      In addition, a potential impact on the vascular system has recently been highlighted by the
      use of these e-cigarettes. Thus, their components can lead to vascular changes in the
      reactivity of blood vessels, an increase in blood pressure or even endothelial dysfunction
      and vascular and cerebral oxidative stress.

      The aim of this study is to detect these phenomena at the level of the retinal circulation,
      window of the central nervous system, in order to be able to confirm the acute vascular
      impacts of the use of an e-cigarette. In addition, the vascular and metabolic impacts due to
      the potential toxicity of the other components of these e-cigarettes could be investigated.
      Finally, the comparison between patients who are smokers and occasional smokers will provide
      a better understanding of the different acute and chronic effects of nicotine.
    


Intervention name(s): RETI-port/scan 21; Zilia Ocular; OCT-A; Electronic cigarette without nicotine; Electronic cigarette with nicotine
Intervention type(s): Device; Device; Device; Combination Product; Combination Product
Intervention description(s): Pattern visual event-related potential and pattern electroretinogram on right eye (non-dilated pupil) at baseline, post e-cigarette vaping without nicotine and post e-cigarette vaping with nicotine.; Eye fundus tissue oximetry measure on left eye (dilated pupil) at baseline, post e-cigarette vaping without nicotine and post e-cigarette vaping with nicotine.; Optical coherence tomography angiography measure on left eye (dilated pupil) at baseline, post e-cigarette vaping without nicotine and post e-cigarette vaping with nicotine.; Vaping using an e-cigarette paired with an e-cigarette liquid vial without nicotine. Inhaling through the mouth and exhaling through the nose ten times. Inhalations must last 5 seconds and the participant has 5 minutes to do the 10 inhalations.; Vaping using an e-cigarette paired with an e-cigarette liquid vial with nicotine. Inhaling through the mouth and exhaling through the nose ten times. Inhalations must last 5 seconds and the participant has 5 minutes to do the 10 inhalations.
Intervention MeSH terms: Nicotine
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science