bioihbjkbjnl/mcl2 huggingface dataset:
The Effects of Preloading Before Beach Chair Position
Condition: Shoulder Injuries; Anesthesia; Hemodynamic Instability
MeSH terms: Shoulder Injuries
Study type: Interventional

Summary: 
      The main objective of this study is whether preloading before positioning would be effective
      for less hemodynamic instability. The study also analyzes that patients with preloading will
      decrease postoperative nausea and vomiting, better surgical satisfaction and shortened the
      duration of surgery and anesthesia.
    

Detailed description: 
      Keeping patients in normovolemic state and hemodynamically stable in anesthesia and intensive
      care practice are important goals of anesthesiologist. It is known that hypotension that
      develops after taking patients to the beach chair position has a negative effect on cerebral
      oxygenation. Aggressive fluid regimes using to prevent hypotension can cause glycocalyx
      damage, edema and organ dysfunction. Also hypertension seconday to vasopressor therapy can
      cause bleeding at the surgical site and impaired surgical visualization during the
      arthroscopic shoulder surgery.

      In the literature, there are studies examine whether the hypotension is the result of
      decreased cardiac output or decreased systemic resistance and what should be the optimal
      treatment , but as far as investigators know, there is no study about effects of preloading
      before the beach chair position on hemodynamic parameters.
    

Intervention name(s): Preloading with crystalloid fluid
Intervention type(s): Drug
Intervention description(s): crystalloid fluid at 10 ml/kg of ideal body weight was administered intravenously in 30 min before the BCP for patients
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Study group - Control group
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: beach chair position; arthroscopic shoulder surgery; preloading; hemodynamic stability; postoperative nausea and vomiting
An Open-Label Maintenance Study of the Enzyme Replacement Therapy Replagal in Patients With Fabry Disease
Condition: Fabry Disease
MeSH terms: Fabry Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will continue to evaluate the safety of using intravenous doses of Replagal for
      two patients with Fabry disease. Fabry disease is a genetic disorder inherited as an X-linked
      recessive trait. It causes a deficiency in the enzyme alpha galactosidase, which normally
      breaks down a lipid, or fatty substance called ceramidetrihexoside, a building block in all
      cells of the body. The deficiency in breaking down the lipid eventually causes that lipid to
      accumulate and injure cells. Vascular, renal, and neurological problems are the results. It
      is not known exactly how lipid accumulation brings about such problems, studies of another
      lipid storage disorder.

      Two patients 7 to 17 years of age who have Fabry disease and have been receiving intravenous
      infusions of Replagal at a dose of 0.2 mg/kg of body weight every 2 weeks may be eligible for
      this study.

      Participants will undergo the following tests and procedures:

        -  Physical examination.

        -  Neurological examination.

        -  Medical and medication history.

        -  Vital signs.

        -  Assessment of height and weight.

        -  Blood tests to determine complete blood count and chemistries.

        -  Electrocardiogram.

        -  Doppler blood flow study.

      Participants will go through a baseline evaluation, over a period of about 1 day. They will
      receive an intravenous infusion of Replagal every other week, at the dose of 0.2 mg/kg of
      body weight. Vital signs will be measured before the infusion and immediately and after and 1
      hour afterward. There will be careful monitoring for allergic reactions and side effects. The
      infusion time takes approximately 40 minutes.

      This study will last at least 1 year, or until the sponsor doing the investigating or the
      drug manufacturer decides to withdraw support of the study.
    

Detailed description: 
      Objectives: This goal of this study is to continue treating two patients with Fabry disease
      using enzyme replacement therapy (ERT) using Replagal (agalsidase alfa) at a dose of 0.2
      mg/kg of body weight administered every 2 weeks. Study Population: Two patients with Fabry
      disease who are currently on clinical research protocols 00-N-0185/TKT011 or 02-N-0220/TKT015
      and who are stable on ERT. Design: This is an open label study. Outcome Measures: Mainly
      safety parameters will be obtained. Study duration is estimated to be 2 years.
    

Intervention name(s): Replagal agalsidase alfa; Replagal
Intervention type(s): Drug; Drug
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Lysosomal Disease; Glycolipid; Stroke; Peripheral Neuropathy; Storage Disorder
Cognitive Control of Language
Condition: Healthy
Study type: Interventional

Summary: 
      The cognitive control of speech is central to human social communication. Two frontal brain
      regions seem to have a critical role: 1) Broca's area (BA) and 2) the mid-cingulate cortex
      (MCC). Current rehabilitation strategy is clearly based on therapies promoting language
      performance. However, there is few evidence that rehabilitation strategies based on
      nonlinguistic aspects of brain function may enhance recovery. Such strategies may benefit
      from knowledge about the primary -nonlinguistic- function of the BA-MCC network. The aim of
      LANGUAGE is to identify this primary function. One hypothesis is that, in non-speaking
      primates, this network is involved in cognitive control of voluntary vocal/orofacial
      production. Specifically, whereas BA may be responsible for the high-level selection of
      orofacial and vocal responses during learning, the face motor representation within the MCC
      may be responsible for performance monitoring, a process inherently required in learning.
      LANGUAGE aims to test this hypothesis by determining in human the anatomo-functional
      organization of the BA-MCC network thanks to functional magnetic resonance imaging (fMRI).
    


Intervention name(s): Training session; First fMRI session; Second fMRI session; Third session of fMRI
Intervention type(s): Other; Other; Other; Other
Intervention description(s): The subjects will be trained to realize several versions of a learning task of conditional visuo-motor associations.; In this session (involving a condition specific to man and a condition that we are certain to obtain in the monkey), subjects will have to learn by trial and error during successive trials, the conditional associations between three abstract stimuli and three Manual responses (3 MRI-compatible mouse buttons).; In this session (involving a condition specific to man and a condition that we are almost certain to obtain in monkeys), subjects will have to learn by trial and error during successive trials, the conditional associations between three abstract stimuli and Three orofacial responses (3 movements of the mouth).; In this session (involving a human-specific condition and a condition we hope to achieve in the monkey), subjects will have to learn by trial-error in successive trials, conditional associations between three abstract stimuli and three verbal or Vocals.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: fMRI; cingulate cortex; adaptation; frontal cortex
Open-Label Comparative Study of Risperidone Versus Olanzapine Versus Quetiapine for Mania in Children and Adolescents With Bipolar I and Bipolar II Disorder
Condition: Bipolar Spectrum Disorder
Study type: Interventional
Phase: Phase 4

Summary: 
      The objective of this study is to compare the safety and effectiveness of Risperidone,
      Olanzapine, and Quetiapine in the treatment of mania in children and adolescents with Bipolar
      disorder over 8 weeks and then over an extension phase. This is an exploratory, open-label
      study, which seeks to determine if there is evidence for efficacy. The results of this study
      will be used to generate hypotheses for a larger study.
    


Intervention name(s): Risperidone; Olanzapine; Quetiapine
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Open treatment with Risperidone; Open treatment with Olanzapine; Open treatment with Quetiapine
Intervention MeSH terms: Olanzapine; Risperidone; Quetiapine Fumarate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Norursodeoxycholic Acid in the Treatment of Primary Sclerosing Cholangitis
Condition: Primary Sclerosing Cholangitis
MeSH terms: Cholangitis; Cholangitis, Sclerosing
Study type: Interventional
Phase: Phase 2

Summary: 
      Evaluation of the efficacy of different doses of nor UDCA vs. placebo for the treatment of
      Primary Sclerosing Cholangitis (PSC). Identification of optimal dose(s)for the treatment of
      PSC.
    

Detailed description: 
      Double-blind, randomized, multi-center, placebo-controlled, comparative exploratory phase
      II-finding trial.The study will be conducted with four treatment groups in the form of a
      parallel-group comparison and will serve to compare oral treatment with either 500 mg/d, 1000
      mg/d or 1500 mg/d norursodeoxycholic acid capsules vs. Placebo capsules for the treatment of
      PSC.
    

Intervention name(s): norUDCA; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Comparison of different dosages of norUDCA acid administered orally.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: PSC
Effect of Caudal Nalbuphine on Postoperative Analgesia in Children
Condition: Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      Nalbuphine as an adjuvant to bupivacaine caudal anesthesia for postoperative analgesia in
      children undergoing Hypospadias repair.

      2 groups, 30 patients each
    


Intervention name(s): Nalbuphine plus Bupivacaine; Bupivacaine
Intervention type(s): Drug; Drug
Intervention description(s): Addition of caudal Nalbuphine to the standard Bupivacaine; Caudal Bupivacaine is the standard of care will be considered as a control
Intervention MeSH terms: Nalbuphine; Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Muscle Function and Pelvic Stability While Walking in Patients With Symptomatic Lumbar Spinal Stenosis
Condition: Symptomatic Lumbar Spinal Stenosis; Lumbar Spinal Stenosis
MeSH terms: Spinal Stenosis; Constriction, Pathologic
Study type: Observational

Summary: 
      This study is to quantify changes in muscle activity and pelvic stability during prolonged
      walking in patients with symptomatic lumbar spinal stenosis (sLSS) and healthy control
      subjects and to determine their association with the severity of the stenosis and the
      crosssectional area and fatty atrophy of lumbo-pelvic-hip muscles.
    


Intervention name(s): Oswestry Disability Index (ODI) questionnaire; self-paced walking test (SPWT)
Intervention type(s): Other; Diagnostic Test
Intervention description(s): Participant's level of low back pain and the extent to which the pain impacts his/ her daily life activities and social life are estimated with the standardized Oswestry Disability Index questionnaire; walking back and forth at a self-selected pace along a hallway at the University Hospital until the onset of claudication, pain or until reaching the time limit of 30 minutes. Kinematic and electromyographic (EMG) data will be recorded every 3 minutes.
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        -  20 patients diagnosed with sLSS scheduled for decompression surgery at the University
             Hospital Basel

          -  20 healthy, age-matched control subjects
      
Keywords: pelvic stability; lumbo- pelvic- hip complex; lumbo-pelvic-hip muscles
Community Care for Croup (RCT)
Condition: Croup
MeSH terms: Laryngitis; Croup
Study type: Interventional
Phase: Phase 4

Summary: 
      This randomized clinical trial was to compare the effectiveness of prednisone 2mg/kg/day for
      3 days vs. dexamethasone 0.6mg/kg for 1 day for treatment of children with mild or moderate
      croup. It was conducted in a practice-based research network of community pediatricians in
      the St. Louis area. Outcomes included additional health care for croup, duration of symptoms,
      nights of disturbed sleep, parental stress, missed work days, and adverse events. Our
      hypothesis was that community-based treatment of children with mild or moderate croup with
      multiple doses of prednisone is superior to a single dose of dexamethasone.
    


Intervention name(s): Prednisone; Dexamethasone
Intervention type(s): Drug; Drug
Intervention description(s): 2 mgs/kg for 3 days; 0.6 mgs for one day, then placebo for 2 days
Intervention MeSH terms: Dexamethasone; Prednisone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Primary Care; Treatment; Croup; Corticosteroids; Prednisone; Dexamethasone; Randomized trial
A Study to Investigate the Safety and Efficacy of ZS in Patients With Hyperkalemia.
Condition: Hyperkalemia
MeSH terms: Hyperkalemia
Study type: Interventional
Phase: Phase 3

Summary: 
      To evaluate the efficacy of two different doses (5 and 10 g) of ZS orally administered once
      daily (qd) vs placebo in maintaining normokalemia in initially hyperkalemic patients having
      achieved normokalemia following 24 or 48 hours of initial ZS therapy (10g TID).
    

Detailed description: 
      This study will be conducted in approximately 35 centers in China. Before patients are
      randomized to the double-blind phase, they will receive open-label ZS for 24 or 48 hours
      during the initial phase. It is expected that approximately 490 patients will need to be
      enrolled, to have approximately 280 patients entered into the open-label initial phase
      resulting in 250 patients being randomized in the 28-day treatment study phase. Enrolment
      will be stopped when 250 patients have been initiated with the 28-day randomized treatment
      study phase.
    

Intervention name(s): Sodium Zirconium Cyclosilicate 5g; Sodium Zirconium Cyclosilicate 10g; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Suspension administered Sodium Zirconium Cyclosilicate 5g orally once daily for 28 days after the open label initial phase with suspension administered Sodium Zirconium Cyclosilicate 10g orally three times per day for at most 2 days.; Suspension administered Sodium Zirconium Cyclosilicate 10g orally once daily for 28 days after the open label initial phase with suspension administered Sodium Zirconium Cyclosilicate 10g orally three times per day for at most 2 days.; Suspension administered orally placebo once daily for 28 days after the open label initial phase with suspension administered Sodium Zirconium Cyclosilicate 10g orally three times per day for at most 2 days.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Efficacy of Scapulothoracic Exercises on Postural Stability, Proprioception, Muscular Features and Mandibular Functions
Condition: Temporomandibular Joint Dysfunction Syndrome; Forward Head Posture
MeSH terms: Joint Diseases; Temporomandibular Joint Disorders; Temporomandibular Joint Dysfunction Syndrome
Study type: Interventional

Summary: 
      The goal of this Randomized, Double-Blind, Clinical Trial is to investigate the effects of
      scapulothoracic exercises on postural stability, muscle strength, muscular endurance,
      mandibular functions and proprioception in sedentary individuals aged 18-45 years with head
      forward posture and temporomandibular joint dysfunction (Cranio-Cervico-Mandibular
      Malalignment). The main questions it aims to answer are:

      • Do Scapulothoracic exercises given in addition to cervical posture exercises have an effect
      on postural stability, proprioception, muscle strength, muscular endurance and mandibular
      functions in individuals with Cranio-Cervico-Mandibular malalignment?

      Researchers will compare conventional neck exercises (control group) and scapulothoracic
      exercises applied in addition to conventional neck exercises (treatment group) to see the
      effects of scapulothoracic exercises on the neck and jaw area.
    

Detailed description: 
      The investigators aimed to investigate the effects of scapulothoracic exercises on postural
      stability, muscle strength, muscular endurance, mandibular functions and proprioception in
      sedentary individuals aged 18-45 years with cranio-cervico-mandibular malalignment including
      head-first posture and temporomandibular joint dysfunction problems.
    

Intervention name(s): Exercises
Intervention type(s): Other
Intervention description(s): For control group; Cervical conventional exercises. For treatment group; scapulothoracic exercises including strengthening, proprioceptive and stabilization exercises in addition to cervical conventional exercises
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized Comparative Double-Blind Study
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Musculoskeletal Rehabilitation; Temporomandibular Joint Treatment; Scapulothoracic Exercises; Cranio-Cervico-Mandibular Malalignment
Effects Of Perturbation Based Balance Training in Reactive Balance Control Among Chronic Stroke Patients
Condition: Stroke
MeSH terms: Stroke
Study type: Interventional

Summary: 
      Chronic stroke patients often have impaired balance on reactive balance control. Task
      specific exercises are important part of the fall intervention in daily activities of life
      should be incorporated during the rehabilitative services Objective: Effects of perturbation
      based balance training in reactive balance control in chronic stroke patients.
    

Detailed description: 
      RCT (Randomized Control Trail) study was conducted. Stroke patients who have impaired balance
      and reactive control were determined on inclusion & exclusion criteria. Stroke patients with
      impaired balance control were arbitrarily allocated into two groups with one control and one
      interventional group ages ranged from 45 to 50 years. The sample size was 20 patients. Group
      1 (control group) received tradional balance training and Group 2 (interventional group)
      received perturbation based training for balance control. The interval of treatment was 6
      weeks. Data is collected from Azra Naheed Medical college (Ch Muhammad Akram teaching &
      research hospital) Lahore and Physiotherapy department of Social security hospital manga
      mandi Lahore. Tinetti performance oriented mobility assessment (POMA),Time up and go (TUG)
      and Activity specific balance confidence (ABC) was used to evaluate the pre and post values
      of balance control.
    

Intervention name(s): perturbation training; Conventional' balance training
Intervention type(s): Other; Other
Intervention description(s): external or internal postural perturbations. External perturbations occur by forces outside the patient' control (e.g., a push or pull from the physiotherapist). Internal perturbations caused when the patient is unable to control the centre of mass and the base of support relationship during voluntary movement; 'agility' tasks, such as kicking a soccer ball,; Starting from a situated position, expand your left leg until it's corresponding to the floor. Try not to bolt your knee. At that point, gradually bring your foot down to the floor. Rehash with your correct leg, exchanging to and fro between legs for a s
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Stroke; Perturbation based training; Fall; Berg balance scale; Performance oriented mobility assessment
Study of an Investigational Nasal Aerosol or Placebo Nasal Aerosol in Children (Ages 6-11) With Seasonal Allergies
Condition: Seasonal Allergic Rhinitis; SAR
MeSH terms: Rhinitis; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal; Hypersensitivity
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to assess the safety and efficacy of an investigational nasal
      aerosol at two doses compared with placebo nasal aerosol in the treatment of seasonal
      allergic rhinitis in children (6-11 years of age).
    


Intervention name(s): BDP HFA; Placebo nasal aerosol
Intervention type(s): Drug; Drug
Intervention description(s): BDP (beclomethasone dipropionate) HFA (hydrofluoroalkane) nasal aerosol administered as a single actuation in each nostril daily for the 15 day treatment period. Each actuation contains either 40 or 80 mcg for a total daily dose of either 80 or 160 mcg depending upon the assigned treatment arm.; Placebo formulated as a nasal aerosol spray and administered as a single actuation in each nostril daily for the 15 day treatment period.
Other intervention name(s): BDP (beclomethasone dipropionate) HFA (hydrofluoroalkane) Nasal Aerosol; QNASL®
Intervention MeSH terms: Beclomethasone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Allergies; Hayfever
Safety of NStride Autologous Protein Solution in the Treatment of Knee Osteoarthritis (PROGRESS I)
Condition: Osteoarthritis, Knee
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of this study is to assess the safety of a single injection of APS.
    

Detailed description: 
      The primary objective of this study is to assess the safety of a single injection of APS in
      patients with painful unilateral knee osteoarthritis and who have not been able to get
      satisfactory pain relief with other treatments through one-month post treatment and monitor
      subjects for adverse events through 12 months.
    

Intervention name(s): APS
Intervention type(s): Biological
Intervention description(s): See above
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment