bioihbjkbjnl/mcl2 huggingface dataset:
β2-agonist Versus Ipratropium Bromide Associated With β2-agonists in Chronic Obstructive Pulmonary Disease Exacerbation
Condition: Acute Exacerbation of Chronic Obstructive Airways Disease
MeSH terms: Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive; Disease Progression
Study type: Interventional
Phase: Phase 3

Summary: 
      The effectiveness of β2-agonists in the treatment of exacerbations of COPD is already
      established. The purpose of this study is to compare the effectiveness of the β2-agonists
      alone in nebulization with the association β2-agonists + Ipratropium bromide in the treatment
      of an acute exacerbation of COPD consulting the emergency departement based on the clinical
      and arterial blood gas.
    

Detailed description: 
      It is a prospective study and randomized performed in patients admitted to the emergency
      departement for acute exacerbation of COPD. The patients were divided in two groups: Group
      Terbutaline/Ipratropium Bromide; received Terbutaline + Ipratropium bromide in nebulization
      and Group Terbutaline received Terbutaline alone in nebulization)
    

Intervention name(s): Bricanyl/Iprovent; Bricanyl
Intervention type(s): Drug; Drug
Intervention description(s): 5 mg Terbutaline sulfate (2ml) + 0,5 mg Ipratropium bromide (2ml) + 1ml serum saline in each nebulization which is repeated three times during 1 hour and every 4 hours during the first 24 hour protocol; 5 mg Terbutaline sulfate (2ml) + 3ml serum saline in each nebulization which is repeated three times during 1 hour and every 4 hours during the first 24 hour protocol
Intervention MeSH terms: Terbutaline
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: β2-agonist; Ipratropium Bromide; Chronic Obstructive Pulmonary Disease Exacerbation; Emergency departement
Cyber Disease Management: Using the World Wide Web to Share the Medical Record With Patients at Home
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      This is a 12-month randomized, controlled trial of a Web-based diabetes co-management module
      among type 2 patients at the University of Washington's Roosevelt General Internal Medicine
      Clinic.
    

Detailed description: 
      We will conduct a randomized controlled trial to determine whether a fully computerized,
      diabetes mellitus (DM) disease-management module (known as Cyber-DM) can improve the quality
      of adult diabetes care. The module will be Web-based, include a graphical HTML "front end"
      user interface, and will be incorporated into each patient's existing Web-based electronic
      medical record --the Medical Information Networked Database (MIND) repository at the
      University of Washington Academic Medical Centers. This Web site will include five components
      that will enable patients to interact asynchronously from their homes with their clinic-based
      providers:

        1. An integrated view of their actual medical record as it relates to diabetes care that
           can generate customized patient education materials.

        2. Real-time clinical reminders of the need to obtain preventive services such as HbA1c,
           urine-protein and cholesterol determinations, and retinal examinations.

        3. An electronic version of the SDMTM diabetes-care algorithms indicating where on the
           "road-map" to adequate control they currently stand treatment-wise.

        4. The ability to download glucometer readings and medication-use information from home
           directly into the MIND repository.

        5. Secure email communication between patients, their primary care physicians, and clinic
           staff.

      A total of 80-85 diabetic patients who are regular utilizers of the UW's General Internal
      Medicine Clinic and who have home Internet access will be randomized to the experimental and
      control arms of the trial. Control subjects will receive usual care. We hypothesize that use
      of Cyber-DM will increase compliance with guideline-indicated care processes, improve
      glycemic control, and reduce utilization costs. A trial this size would have the statistical
      power to detect a change in HbA1c of 0.50%. Secure Socket Layer technology, session specific
      "cookie" files, and a custom database application that manages logins/passwords and audits
      all accesses to the system will provide security for this information tool.
    

Intervention name(s): Internet co-management module
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Educational/Counseling/Training
Keywords: Diabetes; Health Education; Information Technology; Disease Management; Internet; Patient Education
Radiation Dose of Pediatric Patients During Ureteroscopy
Condition: Urolithiasis
MeSH terms: Urolithiasis
Study type: Observational

Summary: 
      The purpose of this study is to quantify the radiation exposure from diagnostic testing and
      surgical treatment during routine endourologic procedures for symptomatic urolithiasis.
    

Detailed description: 
      Routine endourologic procedures will be performed at the Childrens Hospital of Pittsburgh by
      one of the investigators listed on this study. Fluoroscopic radiation exposure during these
      procedures is used to guide the surgical devices that are used to treat the stones. The
      investigators will be measuring the radiation effective skin dose by two methods. First, the
      investigators will place two "Microdot" thermal leak detectors (TLD) on the patient. These
      devices which are the size and thickness of a dime will be within plastic bags taped to the
      patients body within the central focus of the fluoroscopy image. At the completion of the
      procedure the TLD's will be transferred to the Radiation Safety Office in Oakland to be read
      and the dose recorded.

      Second, a flat chamber that is integral with all fluoroscopy machines used at Children's
      Hospital will measure the dose-area product (DAP) for each case which will allow us to
      calculate the effective dose. This device is a component of the colimeter on the arm of the
      x-ray machine used for fluoroscopy. It measures the radiation that is returned to the x-ray
      machine and calculates the dose delivered to the patient by comparing the amount delivered to
      the patient to the amount returned to the machine. Its use is automatic when any x-rays are
      delivered and does not involve any manipulation of the patient or alteration of normal
      procedure.

      No additional procedures or change in duration is necessary for this study
    

Observational model: Other
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients with urolithiasis
Study of MK0928 in Healthy Adult Volunteers in a Model of Insomnia (0928-006)(COMPLETED)
Condition: Insomnia
MeSH terms: Sleep Initiation and Maintenance Disorders
Study type: Interventional
Phase: Phase 3

Summary: 
      A study to evaluate the safety and effectiveness of Study of MK0928 in Healthy Adult
      Volunteers in a Model of Insomnia for insomnia (a sleep disorder).
    


Intervention name(s): gaboxadol
Intervention type(s): Drug
Intervention description(s): Duration of Treatment -1 day
Other intervention name(s): MK0928
Intervention MeSH terms: Gaboxadol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Epidemiology Study of Malaria Transmission Intensity in Sub-Saharan Africa
Condition: Malaria
MeSH terms: Malaria
Study type: Interventional

Summary: 
      This study is designed to characterise P. falciparum transmission intensity in subjects aged
      ≥6 months and <10 years by measurement of P. falciparum parasite prevalence, and to estimate
      the use of malaria control interventions at some centres selected for the EPI-MAL-002 and
      EPI-MAL-003 studies in sub-Saharan Western Africa.
    

Detailed description: 
      Two subsequent studies (EPI-MAL-002 and EPI-MAL-003) are planned to monitor vaccine safety
      prior to and after implementation of the RTS,S/AS01 candidate malaria vaccine. EPI-MAL-002
      will take place before RTS,S is authorised and EPI-MAL-003 will start when RTS,S is
      registered and authorised in the country. A cross-sectional survey at peak transmission will
      provide by-site point estimates of Parasite prevalence (PP) and malaria control measure
      coverage in the areas participating in EPI-MAL-002/-003. EPI-MAL-006 will be conducted in
      advance of EPI-MAL-002/-003 in order to assess PP and malaria control measures to inform
      enrollment in these studies. The age group for enrollment (≥6 months - <10 years) will permit
      analysis of PP according to the World Health Organization (WHO) definition (2-9 years) and by
      the Joint Technical Expert Group (JTEG) suggested age (<5 years).
    

Intervention name(s): Capillary blood sample; Data collection
Intervention type(s): Procedure; Other
Intervention description(s): Capillary blood sample (up to 200µL) for determination of PP (blood slides).; Prospective data collection at the study visit by the internet based Electronic Case Report Form (eCRF)
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Saharan Western Africa; Epidemiology; Post-Approval Programme study; Malaria; Burden of Disease Study
Drug-drug Interaction Study Between Lopinavir/Ritonavir and Isavuconazole
Condition: Pharmacokinetics of Isavuconazole; Pharmacokinetics of Lopinavir/Ritonavir; Healthy Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this two part study is to assess the effect of multiple doses of isavuconazole
      on the pharmacokinetics of multiple doses of lopinavir/ritonavir and the effect of multiple
      doses of lopinavir/ritonavir on the pharmacokinetics of isavuconazole.

      Part 1 of the study includes 12 subjects randomized to receive either isavuconazole alone or
      isavuconazole in combination with lopinavir/ritonavir. The purpose of Part 1 is to evaluate
      safety and tolerability and to establish the effect of multiple doses of lopinavir/ritonavir
      on isavuconazole.

      Part 2, if initiated, includes 54 subjects randomized to receive isavuconazole alone,
      lopinavir/ritonavir alone, or isavuconazole in combination with lopinavir/ritonavir.
    


Intervention name(s): Isavuconazole; Lopinavir/ritonavir
Intervention type(s): Drug; Drug
Intervention description(s): oral; oral
Other intervention name(s): BAL8557; KALETRA®
Intervention MeSH terms: Ritonavir; Lopinavir; Isavuconazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Keywords: Isavuconazole; Lopinavir/ritonavir; Healthy Volunteers; BAL8557; Kaletra ®
A Comparison of the Ambu AuraGain Versus LMA Supreme in Children
Condition: Supraglottic Airway
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether there is a clinically relevant difference
      in airway leak pressures between the Ambu AuraGain and the Laryngeal Mask Airway (LMA)
      Supreme.
    

Detailed description: 
      The goal of this prospective randomized study is to compare whether there is a clinically
      relevant difference in airway leak pressures between the Ambu AuraGain (sizes 1.5 and 2) and
      the Laryngeal Mask Airway (LMA) Supreme. Parameters of clinical relevance such as insertion
      success rates, fiberoptic view of the glottic opening, ease and speed of gastric tube
      placement, airway stability, and peri-operative complications will also be assessed.
    

Intervention name(s): Ambu AuraGain (size 1.5 or size 2.0); LMA Supreme (size 1.5 or size 2.0)
Intervention type(s): Device; Device
Intervention description(s): The device will be inserted and timed. A leak pressure test will be performed after successful insertion and after 10 minutes. The larynx will be visualized by placing a fiberoptic bronchoscope through the device. A gastric tube will be inserted through the device and timed.; The device will be inserted and timed. A leak pressure test will be performed after successful insertion and after 10 minutes. The larynx will be visualized by placing a fiberoptic bronchoscope through the device. A gastric tube will be inserted through the device and timed.
Other intervention name(s): Ambu AuraGain; LMA Supreme
Intervention MeSH terms: Chlorhexidine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Keywords: Supraglottic airway; Laryngeal mask airway; Children
Identifying Very Early Response to Seroquel Extended Release (XR) Augmentation for Major Depressive Disorder
Condition: Depressive Disorder, Major
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 4

Summary: 
      The proposed study is for a 6 week open-label clinical trial in which Seroquel XR is added to
      a selective serotonin reuptake inhibitor (SSRI) medication for the treatment of depressive
      and/or anxiety symptoms. Each subject will self-report changes in symptoms, functional
      impairment, etc. on a twice daily basis using a handheld computer (HHC) that transmits
      real-time symptoms reports to a central database. Each subject will be assessed in-person on
      a weekly or biweekly basis during the course of the study.
    

Detailed description: 
      This study is a 6-week open-label clinical trial in which Seroquel XR is added to an
      antidepressant medication for the treatment of MDD with or without comorbid generalized
      anxiety disorder. Patients who are currently experiencing a depressive episode that has not
      responded to an adequate trial of an antidepressant will be eligible to participate. During
      the course of augmentation treatment with Seroquel XR, each subject will regularly enter
      information on symptom severity and functional impairment into their handheld computer, and
      this information will be wirelessly transmitted to a central database.
    

Intervention name(s): Quetiapine (Seroquel) XR
Intervention type(s): Drug
Intervention description(s): 50mg/day - first 2 weeks 150mg/day - remaining 4 weeks min dose: 50mg/day max dose: 300mg/day
Other intervention name(s): Seroquel XR
Intervention MeSH terms: Quetiapine Fumarate
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Major Depressive Disorder; Seroquel XR; Quetiapine
Evaluation of Architectural Changes in Mandibular Bone Pattern After Functional Treatment by Fractal Dimension Analysis
Condition: Orthopedic Disorder
MeSH terms: Musculoskeletal Diseases
Study type: Observational

Summary: 
      In this study it was aimed to examine the changes in mandibular bone after functional
      treatment by using fractal dimension (FD) and cortical thickness (CT) analysis.
    

Detailed description: 
      In this study it was aimed to examine the changes in mandibular bone after functional
      treatment by using fractal dimension (FD) and cortical thickness (CT) analysis. The study
      will perform on 42 mandibular retrognathia cases. The treatment group (T), comprised of 30
      cases treated with functional appliance for one year in puberty. The control group (C)
      consists of 12 patients who had insufficient oral hygiene; didn't take any orthodontic
      treatment for one year. FD and CT analysis will evaluate for both sides. FD measurements will
      perform on processus condylar, antigonial notch, and ramus regions in the panoramic
      radiographs. Paired t-test will apply to analyze all between groups (before (T1) and after
      treatment (T2), before (C1) and after (C2) control). Also, independent t-test wişll use to
      determine whether there was any difference between the treatment group (∆T=T2-T1) and the
      control group (∆C=C2-C1).
    

Observational model: Case-Crossover
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        The database was taken from the archives between 2017 and 2019 in Recep Tayyip Erdogan
        University. The study will consist of 30 cases treated with the functional appliance and 12
        control patients who had insufficient oral hygiene were not treated for one year. After
        providing oral care cases were treated orthodontically.
      
Keywords: Functional orthodontic appliances; fractal dimension; panoramic radiographs; orthodontics
Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the Knee
Condition: Juvenile Osteochondritis Dissecans
MeSH terms: Osteochondritis; Osteochondritis Dissecans; Osteochondrosis
Study type: Interventional

Summary: 
      The purpose of this study is to compare the functional, clinical and radiographic outcomes
      associated with trans-articular drilling versus retro-articular drilling, two commonly
      employed techniques of operative treatment for stable forms of juvenile osteochondritis
      dissecans (JOCD) lesions. This study also aims to better define the natural history of this
      condition in its most commonly identified pathological state (as a stable lesion) following
      surgical intervention by determining the rate of radiographic healing and any need for
      secondary surgery.
    


Intervention name(s): Retro-articular drilling; Trans-articular drilling
Intervention type(s): Procedure; Procedure
Intervention description(s): Drilling must be performed under AP and lateral fluoroscopic guidance, with no additional drilling in 'trans-articular', or intra-articular trans-condylar fashion.
Use a 0.045 K-wire for drilling.
Minimum of 8 wire passes per square centimeter with no maximum number of wire passes.; Drilling must be performed, under arthroscopic visualization, directly through the articular cartilage, with no additional drilling in 'retro-articular', 'extra-articular', or trans-condylar (through the intercondylar notch)
Use a 0.045 K-wire for drilling
A minimum 4 wire passes per square centimeter, with a maximum of 5 wire passes per square centimeter
Other intervention name(s): antero-grade; extra-articular; antero-grade; extra-articular
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: osteochondritis dissecans (OCD); juvenile osteochondritis dissecans (JOCD); knee osteochondritis dissecans; retro-articular drilling; trans-articular drilling; stable osteochondritis dissecans lesion
Acute Presentation and Management of Abdominal Tuberculosis: A Ten-year Experience at a Tertiary Care Center in Pakistan
Condition: Tuberculosis; Abdomen
MeSH terms: Tuberculosis
Study type: Interventional

Summary: 
      A prospective interventional study was conducted in Services Instituton of Medical Sciences
      all patients who underwent emergency laparotomy from 2008-2018 due to abdominal tuberculosis.
      Data were analyzed using SPSS version 21
    


Intervention name(s): exploratory laparotomy
Intervention type(s): Procedure
Intervention description(s): Patients presenting with acute abdomen were operated. Exploratory Laparotomy of patients was done. Further procedure was done according to peroperative findings. Ileostomy for perforation of gut, stricturoplasty for strictutre, biopsy for mesentric lymphadenopathy
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Cervical Restorations Placed Under Two Isolation Methods
Condition: Non-carious Cervical Lesions
MeSH terms: Uterine Cervical Diseases
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      During restorative procedures, different isolation methods of the operative field can be used
      to promote moisture control and retraction of the gingival tissues. The aim of the present
      clinical trial is to evaluate the effects of two isolation techniques on the clinical
      performance of Class V restorations, as well on the periodontal conditions of restored sites.
      Patients presenting at least two noncarious cervical lesions (NCLs) will be enrolled in this
      study. The NCLs will be randomized into the following groups: (1) isolation performed with
      rubber dam and gingival retraction clamp and (2) isolation provided with cotton rolls and
      gingival retraction cord. Both techniques will be used with a saliva suction device. All
      restorative procedures were performed using a self-etching adhesive system and a nanofilled
      composite resin according to the manufacturer's instructions. The clinical performance of
      restorations will be recorded in terms of fracture and retention of restoration, marginal
      adaptation, marginal staining, postoperative hypersensitivity, and preservation of tooth
      vitality at 1 week, 6 months, 12, 24 and 72 months after placement. The periodontal condition
      of restored sites will be evaluated based on the presence of supragingival plaque, gingival
      marginal bleeding, probing depth, and relative gingival recession.
    


Intervention name(s): Relative isolation with cotton rolls; Absolute isolation with rubber dam
Intervention type(s): Procedure; Procedure
Intervention description(s): Cotton roll group: Moisture control was provided using a labial retractor, cotton rolls and gingival retraction cord placed into the gingival sulcus; Rubber dam group: Moisture control was provided by a rubber dam and a gingival retraction clamp placed in the cervical area of the tooth.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Adhesives.; Composites.; Noncarious cervical lesions.; Clinical performance.; Treatment