bioihbjkbjnl/mcl2 huggingface dataset:
McGrath Series 5 Videolaryngoscope for Double-lumen Tube Intubation
Condition: Intubation; Difficult; Intubation Complication
Study type: Observational [Patient Registry]

Summary: 
      1. Double-lumen tube intubation is difficult, compared with single lume tube.

        2. McGrath Series 5 videolaryngoscope hase been used in difficult airway management, both
           in anesthetized and awake patients.

        3. But there was little information about McGrath Series 5 videolaryngoscope for
           double-lumen tube intubation.
    

Detailed description: 
      In this study, the purpose was to evaluate the success rate and intubation time of McGrath
      Series 5 videolaryngoscope for double-lumen tube intubation in patients without predictors of
      difficult intubation.
    

Intervention name(s): videolaryngoscope
Intervention type(s): Device
Intervention description(s): McGrath Series 5 videolaryngoscope is one kind of portable videolaryngoscopes, which has been usde in both unexpected and anticipated difficult intubation.
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        adult patients scheduled for thoracic surgery requiring double-lumen tube insertion for
        one-lung ventilation
      
Keywords: McGrath Videolaryngoscope; double-lumen tube intubation; Thoracic surgery
Real-time Ultrasound-guided Paramedian Epidural Access: Evaluation of a Novel In-plane Transverse View Technique
Condition: Epidural Placement
Study type: Interventional

Summary: 
      The aim of this study is to demonstrate the feasibility of a new technique using real time
      ultrasound guided paramedian approach to the epidural space. This approach will use
      transverse view of the spine utilizing curvilinear low frequency ultrasound probe "Sonosite S
      nerve" and echogenic 17G tuohy needles " Pajunk TuohySono"

      The investigators believe that this new technique is helpful to get the best anatomic
      landmark for epidural catheter placement using the real-time ultrasound.

      Measurable outcomes:

        -  Block performance time.

        -  Block success rate.

        -  Needle Depth to epidural space

      Block success rate will be measured as the rate of cases that will have successful insertion
      of the epidural catheter using ultrasound guidance and the case is done completely under
      epidural anesthesia.

      All cases that will be converted to general anesthesia will be counted unsuccessful.

      Other measurable outcome data that will be collected will include needle depth to the
      epidural space, and ultrasound measured depth to the lamina
    


Intervention name(s): epidural needle placement with echogenic 17G Tuohy needles (Pajunk TuohySono); standard epidural placement
Intervention type(s): Other; Other
Intervention description(s): Anesthesiologist will place epidural with aid of ultrasound and placement with echogenic 17G Tuohy needles (Pajunk TuohySono); Anesthesiologist will place epidural within standard practice, with standard needles.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: epidural
Effect of Music on Patients' Anxiety During Lower Limb Arthroplasty Procedures Under Spinal Anaesthesia
Condition: Anxiety
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      The aim of this study is to compare the effect of listening to music, to a control group (no
      music), on peri-operative anxiety using the validated VAS-A, in patients undergoing lower
      limb arthroplasty procedures under spinal anaesthesia.
    

Detailed description: 
      Music is becoming an increasingly popular adjunct to traditional medical therapies.
      International studies have shown the numerous benefits of music in a medical setting. Music
      has been used effectively to decrease patients' anxiety under neuraxial anaesthesia for
      caesarean section. There is currently a lack of evidence supporting the use of music to
      reduce patients' anxiety under neuraxial anaesthesia for lower limb arthroplasty procedures.
      The worldwide growth of the ageing population has led to an increased demand for
      arthroplasty. It is imperative that the anaesthetic technique used for this procedure is both
      safe and is associated with high levels of patient satisfaction. The purpose of this study is
      to compare the effect of music, to a control, on peri-operative anxiety in patients
      undergoing lower limb arthroplasty procedures under spinal anaesthesia.
    

Intervention name(s): Music
Intervention type(s): Other
Intervention description(s): Patients will choose a genre of music from the following list; pop, gospel, classical, jazz, and soul, at the preoperative visit. This will be played on disposable ear phones at a self-selected volume for the duration of the surgical procedure.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: In this randomised controlled trial, patients will be identified on the arthroplasty lists. Criteria for inclusion will be determined at the pre-operative assessment. After enrolment, participants will be randomised into two groups in a 1:1 ratio, music (intervention group) and no music (control group). Randomisation will be done using a simple randomisation chart.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Music; Perioperative anxiety; Spinal anaesthesia; Lower limb arthroplasty
A Drug-Drug Interaction Study of Ketoconazole, Rifampicin and Ritonavir-Boosted Atazanavir With Single-Dose RO5093151 in Healthy Volunteers
Condition: Healthy Volunteer
Study type: Interventional
Phase: Phase 1

Summary: 
      This randomized, single-center, open-label, one-sequence, two-period crossover study in three
      parts will assess the effects of multiple doses of ketoconazole, rifampicin and
      ritonavir-boosted atazanavir on the pharmacokinetics of a single dose of RO5093151 in healthy
      male and female volunteers. In Period 1, subjects will receive a single oral dose of
      RO5093151. In Period 2, subjects will receive a single oral dose of RO5093151 and multiple
      oral doses of either ketoconazole, rifampicin or ritonavir-boosted atazanavir. Anticipated
      time on study is up to 8.5 weeks.
    


Intervention name(s): RO5093151; atazanavir; ketoconazole; rifampicin; ritonavir
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): Single oral dose; Multiple oral doses; Multiple oral doses; Multiple oral doses; Multiple oral doses
Intervention MeSH terms: Ritonavir; Atazanavir Sulfate; Rifampin; Ketoconazole
Intervention model: Parallel Assignment
Masking: None (Open Label)
Evaluation of a Novel Method for Integrating Insulin Delivery and Glucose Sensing in Adipose Tissue of Diabetic Patients
Condition: Type 1 Diabetes
MeSH terms: Diabetes Mellitus, Type 1
Study type: Interventional

Summary: 
      The study seeks to use microdialysis and microperfusion techniques to assess the feasibility
      of performing insulin delivery and glucose sensing at a single subcutaneous tissue site.
    

Detailed description: 
      Glucose management in type 1 diabetic patients comprises the measurement of glucose in
      capillary blood obtained by fingersticking and administration of exogenous insulin in the
      form of a subcutaneous bolus injection or continuous subcutaneous infusion.

      The present study seeks to test an alternative treatment approach that combines glucose
      measurement and insulin delivery at a single subcutaneous tissue site, thereby circumventing
      the need for fingerstick blood glucose monitoring. Microperfusion and microdialysis probes
      are applied in type 1 diabetic subjects to perform insulin delivery and glucose sampling at
      the same adipose tissue site. The feasibility of estimating blood glucose concentrations from
      the glucose levels measured at the subcutaneous insulin delivery site is then assessed during
      an overnight fast and an oral glucose tolerance test.
    

Intervention name(s): Glucose measurement at the sc. insulin delivery site
Intervention type(s): Procedure
Intervention description(s): Overnight fasting and oral glucose tolerance test (OGTT) combined with simultaneous subcutaneous insulin delivery and glucose sampling using a single microdialysis or microperfusion probe.
Intervention MeSH terms: Insulin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
The Role of Ureteral Stenting Following Uncomplicated Ureteroscopy for Ureteral and Renal Stones: A Randomized, Controlled Trial
Condition: Ureteroscopy
MeSH terms: Kidney Calculi; Nephrolithiasis
Study type: Interventional

Summary: 
      It is well established that uncomplicated distal ureteroscopy can be safely performed without
      leaving a ureteral stent. However, many urologists continue to leave ureteral stents
      following uncomplicated ureteroscopy, regardless of stone location, due to concerns for
      post-operative complications, patient symptoms and to reduce unplanned medical visits. There
      is a paucity of data regarding the utility of stent placement for proximal ureteral or renal
      stones following ureteroscopy. We have designed a prospective, randomized controlled trial to
      evaluate the role of ureteral stent placement following ureteroscopy and pyeloscopy in
      proximal and renal stones.
    


Intervention name(s): Placement of ureteral stent
Intervention type(s): Device
Intervention description(s): will randomize groups to either receive a postoperative ureteral stent or not.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
The Effects of TZD on Fat Metabolism and Insulin Sensitivity in GH-Replaced GHD Patients
Condition: Growth Hormone Deficiency
Study type: Interventional

Summary: 
      In the present double blind, placebo-controlled, parallel study we evaluated the impact of 12
      weeks thiazolidinedione (TZD) administration on basal and insulin-stimulated substrate
      metabolism in growth hormone-replaced adults with growth hormone deficiency.
    

Detailed description: 
      In human subjects GH (Growth Hormone) acutely antagonises the effects of insulin on glucose
      uptake in skeletal muscle and increases the hepatic glucose production of humans. This has
      clinical implications for patients with active acromegaly, in whom the prevalence of glucose
      intolerance and overt diabetes mellitus is increased. It is also of significance in relation
      to GH replacement therapy in GH-deficient adults not least when considering that a
      substantial proportion of these patients are insulin resistant in the GH-untreated state.
      There is evidence to indicate that the acute insulin antagonistic effects may be balanced
      with time by the favourable effects of GH on body composition and physical fitness, but the
      data are ambiguous. The mechanism underlying these effects of GH are not fully characterised,
      but there is experimental evidence of a causal linked to the concomitant stimulation of
      lipolysis, since GH-induced insulin resistance is partly abrogated when lipolysis is
      pharmacologically suppressed. This is noteworthy since elevated levels of free fatty acids
      (FFA) are also implicated in the pathogenesis of insulin resistance in patients with the
      metabolic syndrome and type 2 diabetes mellitus. Thiazolidinediones (TZDs) are insulin
      sensitizers which function as highaffinity agonists for the nuclear
      peroxisome-proliferator-activated receptor (PPAR) gamma, which improve insulin sensitivity in
      T2DM. PPAR gamma is a nuclear receptor expressed mainly in adipocytes, which activates the
      transcription of genes involved in lipid and glucose metabolism. Administration of TZD in
      T2DM enhances insulin-stimulated glucose uptake via mechanisms including a lowering of
      circulating FFA and a redistribution of fat away from hepatocytes and myocytes and into
      peripheral adipocytes. To our knowledge, the impact of TZDs on GH-induced insulin resistance
      has not previously been reported. Experimental data in human subjects on this issue are of
      potential importance not only in relation to patients with abnormal GH status, but also
      regarding our understanding of the pathogenesis of insulin resistance in general and the
      complex actions of PPAR gamma activation in particular.
    

Intervention name(s): Pioglitazone
Intervention type(s): Drug
Intervention MeSH terms: Pioglitazone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Growth hormone; Lipolysis; Insulin resistance; Pioglitazone; Growth hormone replaced growth hormone deficient adults
Comparison of Ultrasonic Pachymetry With Orbscan in Corneal Haze
Condition: Corneal Opacity
MeSH terms: Corneal Opacity
Study type: Observational

Summary: 
      This study is planned to compare the results of ultrasonic and Orbscan pachymetry in corneal
      haze not related to surgery. Corneal haze is graded with slit-lamp by a single examiner.
      Ultrasonic and Orbscan II pachymetry measurements are obtained. Paired t and Kruskal-Wallis
      tests are used to evaluate the difference between ultrasonic and Orbscan pachymetry
      measurements. Correlation of the two methods and haze grade is determined with Kendall's
      tau-b correlation analysis.
    

Detailed description: 
      We planned this study to compare the results of ultrasonic and Orbscan pachymetry in corneal
      haze not related to surgery. In this institutional based, prospective, controlled clinical
      trial subjects with corneal haze not related to surgery are included. Normal eyes are used as
      control group to calculate the customized acoustic factor. Corneal haze is graded with
      slit-lamp by a single examiner. Ultrasonic and Orbscan II pachymetry measurements are
      obtained by one technician each masked to the other measurement. Paired t and Kruskal-Wallis
      tests are used to evaluate the difference between ultrasonic and Orbscan pachymetry
      measurements. Correlation of the two methods and haze grade is determined with Kendall's
      tau-b correlation analysis. According to the results of the study, we will determine which
      method is accurate in subjects with corneal haze.
    

Observational model: Defined Population
Time perspective: Other
Keywords: Corneal topography, corneal opacity, keratitis, trachoma
Yoga Nasal Irrigation in the Treatment of Chronic Tension Type Headache
Condition: Chronic Tension-Type Headache
MeSH terms: Tension-Type Headache; Headache
Study type: Interventional

Summary: 
      To evaluate the effectiveness of Yoga Nasal Irrigation (Jalaneti) on patients with chronic
      tension-type headache reducing pain and disability.
    


Intervention name(s): Jalaneti
Intervention type(s): Other
Intervention description(s): Sterilised and lukewarm isotonic salt water using neti pot was poured into one nostril, so that it leaves through the other. The procedure is then repeated on the other side, and the nose is dried by bending forward and by rapid yoga breathing
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Safety and Immunogenicity of Haemophilus Influenzae Type b Vaccine in Different Injection Site
Condition: Healthy
Study type: Interventional
Phase: Phase 4

Summary: 
      The objective of this study was to evaluate the safety and immunogenicity of Haemophilus
      influenzae type b vaccine in different injection site.
    

Detailed description: 
      A randomized trial was conducted in 680 healthy infants with Hib vaccine of two brands. The
      different sub-groups were selected randomly based on the plan to inoculate vaccines in the
      upper arm deltoid or vastus lateralis muscle. The safety and immunogenicity were assessed
      after three or two doses.
    

Intervention name(s): Inoculation in upper arm deltoid; Inoculation in vastus lateralis muscle
Intervention type(s): Biological; Biological
Intervention description(s): Inoculation of Hib vaccine of two brands in upper arm deltoid; Inoculation of Hib vaccine of two brands in vastus lateralis muscle
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Probiotics in the Treatment of Irritable Bowel Syndrome
Condition: Irritable Bowel Syndrome
MeSH terms: Irritable Bowel Syndrome; Syndrome
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      Evidence have shown benefits of gut flora modulation in treatment of irritable bowel syndrome
      (IBS), but few reports are available on the effects of multistrain probiotics and there are
      few reports available in this regard from our society. Thus, we investigated if probiotics
      are effective in our patients as well. We hypothesize that the multistrain probiotic Balance
      containing seven bacteria species including Lactobacillus strains, Bifidobacterium strains,
      and Streptococcus thermophiles reduces the symptoms of irritable bowel syndrome.
    


Intervention name(s): Probiotic; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Patients in the probiotic group received the probiotic compound Balance® (Protexin Co., Somerset, UK) or similar placebo, twice daily after meal for 14 consecutive days. Balance® capsules contains seven bacteria species including Lactobacillus strains (L. casei, L. rhamnosus, L. acidophilus, and L. bulgaricus), Bifidobacterium strains (B. breve and B. longum), and Streptococcus thermophiles. Total viable count (TVC) is 1 x 108 CFU/per capsule. Other Ingredients are Fructo-oligosaccharide as prebiotic, magnesium stearate, and hydroxypropyl methyl cellulose.; Patients in the placebo group received the placebo capsule twice daily after meal for 14 consecutive days.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Irritable bowel syndrome; Functional gastrointestinal disorders; Gut flora; Probiotics
The Effect of Gastric Bypass on the Pharmacokinetics of Serotonin Reuptake Inhibitors
Condition: Gastric Bypass; Depression; Anxiety Disorder
MeSH terms: Depression; Anxiety Disorders
Study type: Observational

Summary: 
      The morbidly obese frequently present with mood and anxiety disorders, which are often
      treated with serotonin reuptake inhibitors (SRI) antidepressant drugs. The investigators
      hypothesized that gastric bypass surgery would decrease the absorption of SRI. The
      investigators also wished to determine whether a reduction in SRI levels would increase the
      likelihood of worsening depressive symptoms.
    

Detailed description: 
      Twelve RYGB candidates who were successfully treated with an SRI for primary mood or anxiety
      disorders were studied prospectively. Blood samples for SRI plasma levels were drawn
      immediately after dose for pharmacokinetic studies (PK) preoperatively. Maximum concentration
      (CMAX), time to CMAX (TMAX), and Area Under Concentration/Time curve (AUC) were determined.
      PK studies were repeated at one, six, and twelve months post-operatively. PK data were
      corrected for dose at each study time point. The Structured Interview Guide for the Hamilton
      Depression Rating Scale- Atypical Depression Symptom Version was used to quantify depressive
      symptoms.
    

Intervention name(s): Roux-en-Y gastric bypass (RYGBP)
Intervention type(s): Procedure
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Bariatric surgery clinic- Morbidly obese patients seeking RYGB who met criteria for
        bariatric surgery (BMI ≥ 40 kg/m2 or ≥ 35 kg/m2 with severe obesity-related comorbidities)
        and were received maintenance treatment with an SRI for primary mood or anxiety disorder.
      
Keywords: pharmacokinetics; serotonin reuptake inhibitors; gastric bypass; depression; bioavailability; drug absorption; area under curve
Efficacy, Safety, and Tolerability of JNJ-27018966 (Eluxadoline) in the Treatment of Irritable Bowel Syndrome With Diarrhea
Condition: Irritable Bowel Syndrome
MeSH terms: Irritable Bowel Syndrome; Syndrome; Diarrhea
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine the efficacy, safety, and tolerability of different
      doses of JNJ-27018966 (eluxadoline) compared with placebo in the treatment of patients with
      irritable bowel syndrome with diarrhea (IBS-d).
    


Intervention name(s): Eluxadoline; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Tablets, orally, twice daily.; Matching placebo oral tablets twice daily.
Other intervention name(s): JNJ-27018966
Intervention MeSH terms: Eluxadoline
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Irritable bowel syndrome with diarrhea; Irritable bowel syndrome; Diarrhea predominant irritable bowel syndrome; Colonic diseases; Colonic diseases, functional; Digestive system disease; Gastrointestinal disease; Intestinal disease; Colonic pseudo-obstruction; Diarrhea; Signs and Symptoms, Digestive
Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy
Condition: Epilepsy
MeSH terms: Epilepsy; Epilepsy, Temporal Lobe
Study type: Interventional

Summary: 
      Epilepsy affects 0.7% of the general population and 15-20% of patients develop drug
      resistance. The temporal lobe epilepsy (TLE) is the most common symptomatic focal epilepsies
      with a particularly high rate of drug (about 20 to 30%). In this type of epilepsy, where
      feasible, surgical removal of the home is the best therapeutic outcome.

      Mechanisms of epileptogenesis and drug resistance are still mysterious. Of recent clinical
      and experimental studies have shown that dysfunction of the blood-brain barrier (BBB)
      contributes to epileptogenesis and drug resistance. It is now recognized that cytokines
      exacerbate the excitability and permeability of the BBB, which was recently confirmed by
      studies showing that treatment of inflammation reduces epileptogenesis. Moreover, we have
      described an association between pathological angiogenesis and BBB permeability in the tissue
      of patients with excision of drug-resistant TLE. With experimental models, it was revealed an
      activation of the VEGF-VEGFR2 by seizures leading to rapid degradation of the BBB.

      The investigators hypothesis is that the identification of factors involved in BBB
      permeability may designate potential targets for drug-resistant partial epilepsy.
    


Intervention name(s): blood sampling for drug resistance biomarkers; Magnetic Resonance Imaging
Intervention type(s): Other; Device
Intervention description(s): comparison of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic