bioihbjkbjnl/mcl2 huggingface dataset:
Isolation and Establishment of Gustatory Cell Lines in Patients Operated on for Cancer of the Mobile Tongue - ImmortTasteCELL
Condition: Cancer of the Tongue
MeSH terms: Tongue Neoplasms
Study type: Observational

Summary: 
      In terms of incidence, cancer of the tongue is one of the leading cancers in France.
      Moreover, this cancer is associated with physiological complications ranging from swallowing
      disorders to loss of taste. Following surgery, impaired perception of food taste may lead to
      cachexia. It is therefore necessary to carry out research in the field of impaired taste,
      notably with regard to the regeneration of taste buds. However, there is currently no
      available functional model of taste bud cells.

      It is therefore necessary to obtain a cell line of human taste cells. These immortalised
      human cells will allow us to better orient our investigations for applications in humans:
      search for and characterisation of "taste modifiers" synthesised using organic chemistry,
      able to trigger the perception of food in cases of taste loss or taste impairment.

      Moreover, given recent studies conducted by the investigating team proposing the existence of
      a fatty taste and its implication in obesity, the work of the team could be oriented towards
      the synthesis of lipid-receptor agonists, by analogy with artificial sweeteners instead of
      sugar. The availability of these chemical molecules would lead to a reduction in lipid intake
      as these agents contain no (or very few) calories. They will act as an organoleptic decoy.
    


Intervention name(s): Sample of cancerous epithelium from the tongue
Intervention type(s): Procedure
Intervention description(s): Harvesting and culture of cancerous epithelium from the surgical piece
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        patients undergoing surgery
Neck Anatomy and Phrenic Nerve Palsy After BPB
Condition: Diaphragm; Paralysis
MeSH terms: Paralysis
Study type: Observational

Summary: 
      The purpose of this study was to determine the association between the anatomical
      characteristics of neck and postoperative diaphragmatic paralysis in patients undergoing
      interscalene brachial plexus block before shoulder arthroscopic surgery.
    

Detailed description: 
      The purpose of this study was to determine the association between the anatomical
      characteristics of neck and postoperative diaphragmatic paralysis in patients undergoing
      interscalene brachial plexus block before shoulder arthroscopic surgery. In addition, we want
      to identify risk factors for diaphragmatic paralysis after brachial plexus block. Through
      this study, we can find the basis for predicting the possibility of diaphragmatic paralysis
      after brachial plexus block according to the patient's anatomical characteristics and
      procedural factors.
    

Intervention name(s): Interscalene brachial plexus block
Intervention type(s): Procedure
Intervention description(s): Interscalene brachial plexus block is performed at ipsilateral side of the affected shoulder.
Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Adult patients over 19 years undergoing shoulder arthroscopic surgery for a rotator cuff
        tear repair under general anesthesia
Trial to Investigate the Effect of Schistosoma Mansoni Infection on the Response to Vaccination With MVA85A in BCG-vaccinated African Adolescents
Condition: Tuberculosis
MeSH terms: Tuberculosis
Study type: Interventional
Phase: Phase 2

Summary: 
      Mycobacterium tuberculosis (M. tb) is a pathogen with worldwide distribution which infects
      humans causing tuberculosis (TB), a transmissible disease resulting in very high mortality
      and morbidity; development of an effective vaccine is a global health priority.

      Over a billion people worldwide are infected with one or more helminths. Helminths are
      parasitic worms, of which Schistosoma mansoni is one species. There is some evidence that
      helminth infection may affect a person's response to a vaccine. In this trial the
      investigators hope to investigate whether Schistosoma mansoni infection affects adolescents'
      responses to a candidate TB vaccine called MVA85A, as adolescents are a crucial target group
      for an effective TB vaccine.
    


Intervention name(s): MVA85A
Intervention type(s): Biological
Intervention description(s): Single dose of 1x10^8pfu MVA85A intramuscular vaccination
Other intervention name(s): Modified Vaccinia Ankara 85A; AERAS-485
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Tuberculosis; Phase II; MVA85A; Schistosoma mansoni
Black Walnuts and Health
Condition: Healthy
Study type: Interventional

Summary: 
      Walnuts are a nutrient dense food, but most health research is on English walnuts (EW). Black
      walnuts (BW) contain a different antioxidant and fatty acid profile, and more protein,
      compared to EW. The purpose of the study was to compare postprandial responses following the
      consumption of 3 breakfast meals containing either butter (control), BW, or EW.
    

Detailed description: 
      This study was a randomized, double-blind control trial consisting of 3 study visits for 3
      different treatments. The treatments were high-fat breakfast muffins containing either butter
      (control), black walnuts, or English walnuts. The investigators recruited healthy,
      normal-weight adults between the ages of 15 and 45y. Study visits were completed in a random
      order with at least 72 hours between each visit. Anthropometrics, questionnaires, and fasting
      and postprandial blood samples were collected at each visit.

      Hypothesis: The walnut-containing meals would mitigate post-meal increases in glucose,
      insulin, triglycerides (TG), and lipid peroxidation while improving all measures of
      subjective appetite and TAC compared to the traditional meal without nuts.
    

Intervention name(s): Control; Black walnut; English walnut
Intervention type(s): Other; Other; Other
Intervention description(s): Participants in this group received a traditional muffin with butter as the predominant source of fat.; Participants in this group received a muffin in which part of the butter was substituted out for black walnuts.; Participants in this group received a muffin in which part of the butter was substituted out for English walnuts.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Other
Clinical Study About Blood Pressure Measurement Efficacy on Multifunction KEITO
Condition: Blood Pressure
Study type: Interventional

Summary: 
      The purpose of this trial is to determine the accuracy of the Blood Pressure (BP) measurement
      of multifunction KEITO devices under test requirements of the Standard American National
      Standards Institute(ANSI)/Association for the Advancement of Medical
      Instrumentation(AAMI)/International Organization for Standardization (ISO): ANSI/AAMI/ISO
      81060-2:2009.
    

Detailed description: 
      Nowadays is important controlling our basic health parameters. Due this, the multifunction
      KEITO Devices was designed to offer to the general public a convenient way to do so easily in
      the public sites.

      One of the most important parameter is the Blood Pressure (BP)measurement. To warrant their
      efficacity and accuracy, was essential to perform this trial to ensure that the measurements
      obtained meet with the requirements of the specific U.S. standard about Non-invasive
      sphygmomanometers.

      By Validating with auscultatory reference sphygmomanometer, as defined on the ANSI/AAMI/ISO
      81060-2:2009 , we have been intending to demonstrate that the multifunction KEITO devices,
      particularly about the Blood Pressure (BP) Measurement, have the same efficacy and accuracy
      as the conventional auscultatory sphygmomanometers.

      To include most of the groups of Blood Pressure (BP) measurements types on this clinical
      trial, a great variety of BP ranges have been selected, always in accordance with the
      standard.
    

Intervention name(s): Reference sphygmomanometer; Sphygmomanometer under test
Intervention type(s): Device; Device
Intervention description(s): * USED Audible Korotkoff (K5)for Auscultatory sphygmomanometer.; Electronic Oscillometric method.
Other intervention name(s): *Ref Auscult. sphygm.: RIESTER MINIMUS S/N 20534567; * Multifunction KEITO K7 S/N 1941.
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: Non Invasive Blood Pressure measurement study.
NI-0801 in Allergic Contact Dermatitis
Condition: Allergic Contact Dermatitis
MeSH terms: Dermatitis; Dermatitis, Contact; Dermatitis, Allergic Contact
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of the study is to assess the effect of a single dose of NI-0801 on the severity
      of nickel-induced allergic contact dermatitis.
    


Intervention name(s): Placebo; NI-0801
Intervention type(s): Drug; Drug
Intervention description(s): single i.v. administration; single i.v. administration
Allocation: Randomized
Reducing Hemarthrosis in Tibial Tubercle Osteotomy by the Administration of Intravenous Tranexamic Acid
Condition: Tibial Tubercle Osteotomy
MeSH terms: Hemarthrosis
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of the proposed study is to evaluate the effects of administering intravenous
      tranexamic acid (TXA) to patients undergoing high tibial osteotomy (HTO) and tibial tubercle
      osteotomy (TTO) to minimize hemarthrosis within the knee joint and post operative pain and
      swelling.
    

Detailed description: 
      Not Provided
    

Intervention name(s): Tranexamic Acid (TXA)
Intervention type(s): Drug
Intervention description(s): One gram of intravenous tranexamic acid (TXA) will be administrated before tourniquet inflation and before closure of the incision, as 1 g has been shown to be a safe amount with minimal side effects
Intervention MeSH terms: Tranexamic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Tibial Tubercle Osteotomy; Tranexamic Acid
The Effect of Antihypertensive Drugs on Severity of Anaphylaxis and Side-effects During Venom Immunotherapy
Condition: Hymenoptera Venom Allergy; Antihypertensive Treatment
MeSH terms: Anaphylaxis; Venom Hypersensitivity
Study type: Observational

Summary: 
      There is an ongoing debate whether antihypertensive treatment with beta-blockers and/or
      angiotensin converting Enzyme (ACE)-inhibitors comprises a risk factor for more severe and
      more frequent side-effects during venom immunotherapy (VIT). In the literature, data are
      controversial and originate from case reports or statistically underpowered studies; the
      number of included patients was usually high but the proportion of patients on
      antihypertensive treatment was low ranging from 2-11%.

      The study was conducted as a prospective, observational, European multicenter study. 1425
      patients, aged from 35 to 85 years, with a history of an anaphylactic reaction due to bee or
      wasp stings, were included. The medical history was recorded as well as laboratory parameters
      and data of the VIT-updosing phase. One year after reaching the maintenance dose, possible
      side-effects during VIT as well as the outcome of field stings or sting challenges were
      documented.
    


Intervention name(s): Insect Venom
Intervention type(s): Drug
Intervention description(s): Patients receive insect venom immunotherapy. The frequency of systemic side-effects is recorded and compared between patients under antihypertensive treatment and patients not taking antihypertensive drugs.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        patients with a history of anaphylactic sting reaction
Physiotherapy in Lumbar Disc Pathologies
Condition: Lumbar Disc Disease; Lumbar Disc Herniation; Low Back Pain, Mechanical; Low Back Strain
MeSH terms: Intervertebral Disc Displacement; Low Back Pain
Study type: Interventional

Summary: 
      The aim of this study is to compare the effectiveness of four physical therapy treatment
      approaches for lumbar region pathologies. Eighty volunteers who have back pain will be
      included in the study. Subjects will be randomly divided into four groups; Group 1: Soft
      tissue mobilisation techniques and stabilization exercises (n=20), Group 2: Kinesiotape and
      stabilization exercise (n=20), Group 3: Stabilization exercises (n=20), Group 4: Reflexology
      and stabilization exercises (n=20).
    

Detailed description: 
      All patients will be measured with visual analog scale for pain level, goniometric
      measurement for range of motion, hamstring tension and sit and reach for flexibility,
      isokinetic evaluation for strength in 60degree/ sec, Side plank position test for trunk
      stabilization.

      Function will be measured with Oswestry Disability Index. Manual muscle testing for flexion,
      extension, lateral flexion of back, flexion, extension, abduction of hip, flexion, extension
      of knee and inversion, eversion of ankle will be assessed. Group 1, 2 and 4 will be started
      to treatment twice a week for 4 weeks after first evaluation. Group 3 will be had home
      exercise programme after first evaluation.

      Groups will be assessed again at 4th and 8th weeks after treatment. Multiway variant analysis
      will bee done within each group before the treatment and at follow-up. When differences
      observed, Tukey test will be used to find out the group that caused the differences.
    

Intervention name(s): Effectiveness of four physical therapy approaches (soft tissue manual therapy, Kinesio® Taping techniques, stabilization exercises and reflex therapy) for treating lumbar disc pathologies.
Intervention type(s): Other
Intervention description(s): Visual analog scale (VAS) scores for pain intensity, goniometric measurements for the range of motion and hamstring flexibility, the sit and reach test for flexibility, an isokinetic evaluation for strength at 60°/sec, and a side-plank position test for trunk stabilization were measured. The functional status was evaluated with the Oswestry Disability Index. All groups were assessed at the beginning, after a four-week treatment and four weeks of follow-up.
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Study of TPI 287 Administered Every 21 Days in Patients With Advanced Malignancies
Condition: Neoplasms; Hodgkin's Disease; Non-Hodgkin's Lymphoma
MeSH terms: Lymphoma, Non-Hodgkin; Hodgkin Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      Tapestry Pharmaceuticals, Inc. has developed a novel taxane analog, TPI 287. TPI 287 is
      synthetically manufactured from naturally occurring taxanes extracted from yew starting
      material. The synthesis involves modification to the taxane side chain to overcome multidrug
      resistance and to achieve mutant tubulin binding. This study will be a multi-center, dose
      escalation, sequential group, Phase 1 study evaluating the intravenous administration of TPI
      287 on an every 21 day cycle.
    

Detailed description: 
      The primary objective of this study is to determine the maximum tolerated dose of TPI 287
      administered every 21 days for Phase II clinical trials.
    

Intervention name(s): TPI 287 Injection
Intervention type(s): Drug
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: taxanes; multidrug resistance; mutant tubulin binding; Hodgkin's or Non-Hodgkin's Lymphoma
Investigation of the Effect of Short-term Orthokeratology With Increased Compression Factor on Ocular Parameters
Condition: Myopic Progression
MeSH terms: Disease Progression
Study type: Interventional

Summary: 
      Orthokeratology (ortho-k) is a clinical technique that uses reverse geometry rigid gas
      permeable contact lens exerting positive pressure on the central cornea to temporary reduce
      refractive error. Researchers have shown that this treatment is effective for myopia control
      in low to high myopes, with and without astigmatism. Most designs of ortho-k lenses in the
      market are fitted based on the Jessen formula. The compression factor was introduced to
      compensate for the regression of the ortho-k effect during the no lens-wear period, so that
      the wearer can obtain clear distance vision throughout the day and most lens designs use a
      compression factor of 0.50-0.75 D. However, in a retrospective study (mixed brands of ortho-k
      lenses), it showed that most patients did not achieve an over-correction of 0.75 D. In order
      to achieve an over-correction of 0.75 D, an extra flattening power of about 1.50 D instead of
      0.75 D should be be targeted. The increased compression factor is expected to increase the
      target reduction and it may play a role in myopic control and providing a higher successful
      rate in fitting ortho-k lenses.
    

Detailed description: 
      Subjects were fitted with ortho-k lenses of conventional (0.75 D) and increased (1.75 D)
      compression factor. The laterality of the compression factor for each subject was randomised.

      Subjects were instructed and trained with proper lens handling and disinfection procedures.
      Lenses were given to the subjects only when they demonstrated proper techniques.

      All subjects were required to attend regular follow-ups (baseline, first overnight, and
      weekly over one-month period). The follow-ups were scheduled (except for the first overnight
      which was scheduled in the early morning) at a similar time to the baseline visit (+/- 2
      hours) to minimise any potential influence of diurnal variation on ocular biometrics.

      Additional unscheduled visits were provided when necessary to ensure good ocular health and
      vision throughout the study period.
    

Intervention name(s): Orthokeratology
Intervention type(s): Device
Intervention description(s): It is a kind of rigid permeable lens.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: myopia control; orthokeratology
Double and Single Intrauterine Insemination In Controlled Ovarian Stimulation (COH) Cycles With Multifollicular Development
Condition: Infertility
MeSH terms: Infertility
Study type: Interventional
Phase: Phase 4

Summary: 
      Our hypothesis is double insemination will improve pregnancy rates in coh cycles with more
      than one dominant follicles (>16mm).
    

Detailed description: 
      Metaanalysis for the effects of double IUI demonstrates that effects of this procedure is not
      different from single IUI. It is known that nearly 25% of coh cycles is evident by
      monofollicular development.For this reason it is possible that this monofollicular cycles in
      the studies could decrease the effects of double IUI.

      Inclusion criteria:

        1. Patients with unexplained infertility or mild male factor infertility whom admitted to
           the COH+IUI programme in our infertility unit.

        2. Female age <37 years old.

        3. Baseline FSH <12 mIU/L

        4. Total antral follicle count>6

        5. During the first three cycles of COH+IUI

        6. Minimum 2 follicles >16 mm at the day of HCG.

      Primary outcome:

      Ongoing pregnancy rates

      Secondary outcomes:

      The effects of different coh regimens (CC,FSH,CC+FSH)on the outcomes.
    

Intervention name(s): Intrauterine insemination (single); Double intrauterine insemination
Intervention type(s): Procedure; Procedure
Intervention description(s): Single IUI after 36-38 hours of HCG; Double insemination after 18 and 40 hours of HCG administration.
Other intervention name(s): Group I; Grup II
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Double IUI; Intrauterine insemination; Unexplained infertility
Pilot Study of Human Adipose Tissue Derived Exosomes Promoting Wound Healing
Condition: Wounds and Injuries
MeSH terms: Wounds and Injuries
Study type: Interventional

Summary: 
      This study is a one-arm pilot study. All patients were recruited on an outpatient basis.
      After screening visits and informed consent was obtained, debridement and photography were
      performed on the patient's wound surface, and the wound area was measured. Patients in the
      intervention group were then provided with adipose tissue exosome dressings.200-300ml of the
      subject adipose tissue before centrifugation was collected, and the extracellular vesicles
      were retained after tissue homogenate and filter screening. The extracellular vesicles were
      mixed with sterile hydrogel and applied directly to the wound surface, and the wound was
      covered with an inert protective dressing.
    

Detailed description: 
      After giving written informed consent, participants will be followed up once a week during
      the 2-week lead-in period to confirm that they meet the inclusion criteria.Patients who meet
      inclusion and exclusion criteria at the end of the induction period will receive treatment
      twice a week for 4 weeks or until recovery, whichever occurs first.When the observer
      confirmed that the wound had healed, the patient was followed up for two healing visits
      within the next 2 weeks.If the evaluator confirms target wound healing at the 4-week
      confirmatory follow-up, subjects will enter the study follow-up phase, which will be
      completed at 4 and 6 weeks after the end of the initiation phase.If the target wound did not
      heal after 6 weeks of treatment, participants completed follow-up at 4 and 6 weeks after the
      initiation period.
    

Intervention name(s): Adipose tissue derived exosomes
Intervention type(s): Procedure
Intervention description(s): 200-300ml of the subject adipose tissue before centrifugation was collected, and the extracellular vesicles were retained after tissue homogenate and filter screening. The extracellular vesicles were mixed with sterile hydrogel and applied directly to the wound surface, and the wound was covered with an inert protective dressing.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment