The Effect of Sevoflurane and Desflurane on Clara Cell Protein on the Lung
Condition: Inhalation Anesthesia; Lung Injury
MeSH terms: Lung Injury
Study type: Interventional

Summary: 
      Inhalation anesthesia; It means that the anesthetic drugs taken by the respiratory tract pass
      into the blood through the lung alveoli, reach the brain tissue, and create an anesthetic
      effect according to the density in the brain tissue. All inhalation anesthetics affect organ
      functions to varying degrees. Clara cell has been shown to have cell regeneration,
      immunomodulatory, anti-inflammatory and antioxidant activity in the bronchial epithelium. It
      is also thought that some substances accumulated in the respiratory system participate in the
      detoxification. Clara cell protein acts as a protein marker that indicates the severity of
      airway injuries after exposure to irritants. In this study, we planned to investigate the
      effect of inhalation anesthetics on Clara cell protein in liver transplant donors who will
      undergo hepatectomy surgery.
    

Detailed description: 
      Inhalation anesthesia is still an important source of chemical hazard in the hospital
      environment due to its widespread use in operating rooms. Factors affecting the presence of
      anesthetic gases in the environment; device leakage, ventilation, fresh gas flow, and
      operation of the air cleaning system. Long-term exposure to anesthetic gases is known to
      adversely affect the health of employees in the operating room.

      Clara cell plays a reliable role as a large bronchiolar progenitor cell that can contribute
      to cell regeneration in the bronchial epithelium. Thus, it contributes to the protection of
      the normal epithelium of the distal conductive airways. Additionally, it has been shown to
      have immunomodulatory, anti-inflammatory, and antioxidant activity. It is thought that some
      substances accumulated in the respiratory system participate in the detoxification.

      Operations of patients undergoing hepatectomy usually take 4-6 hours. Inhalation anesthetics
      are widely used during this surgery. In this study, we thought to show the effect of
      long-term inhalation anesthesia exposure by performing this surgery on patients in this
      group. In this study, we aimed to investigate the effect of sevoflurane and desflurane
      inhalation anesthetics on clara cell protein in liver transplant donors scheduled for
      hepatectomy surgery.
    

Intervention name(s): Sevoflurane; Desflurane; Propofol
Intervention type(s): Drug; Drug; Drug
Intervention description(s): In the sevoflurane group (n = 25), after the induction of anesthesia with 2 mg / kg propofol and 1 µg / kg remifentanyl, rocuronium 0.6 mg / kg will be given for intubation. In this group, the Sevoflurane concentration will be adjusted between 1-2%, the BIS value will be 40-60, and it will be inhaled with an air / O2 mixture to be FiO2: 0.4.; In the desflurane group (n = 25), after induction of anesthesia with 2 mg / kg propofol and 1 µg / kg remifentanyl, rocuronium 0.6 mg / kg will be given for intubation. In this group, Desflurane concentration will be adjusted between 6-8%, BIS value will be 40-60 and it will be inhaled with a mixture of air / O2 mixture to be FiO2: 0.4.; In the propofol-remifentanyl group (n = 25), rocuronium 0.6 mg / kg will be administered for intubation after 2 mg / kg propofol and 1 µg / kg remifentanil. Maintenance of anesthesia will be adjusted to be between 10 mg / kg / h for the first 10 minutes, 8 mg / kg / h for the following 10 minutes, and then by 6 mg / kg / h propofol infusion, with the BIS value between 40-60. Patients in this group will be inhaled with a mixture of air / O2 to be FiO2: 0.4. Inhalation anesthetics will not be used in this group.
Other intervention name(s): TIVA(propofol-remifentanyl)
Intervention MeSH terms: Propofol; Sevoflurane; Desflurane
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Diagnostic
Keywords: Sevoflurane; Desflurane; Clara cells protein