bioihbjkbjnl/mcl2 huggingface dataset:
Fetuin A Association in Periodontal Disease and Diabetes Mellitus
Condition: Periodontitis, Adult
MeSH terms: Periodontitis; Chronic Periodontitis
Study type: Observational

Summary: 
      Aim: The aim of the current study was to compare and correlate gingival crevicular fluid
      (GCF) fetuin-A levels and high sensitivity C-reactive protein (hs-CRP) levels in non-diabetic
      periodontitis patients and type 2 diabetic periodontitis patients with healthy subjects and
      revealing its possible role in diagnosis of periodontal disease.

      Methodology: Forty-five periodontitis stage III patients categorized into 3 groups according
      to whether having type II diabetes mellitus or not were compared to systemically and
      periodontally healthy participants in this investigation. Clinical parameters for all groups
      were recorded. Assessment of GCF levels of fetuin A and hs-CRP were done to all enrolled
      participants utilizing an enzyme linked immune-sorbent assay (ELISA) kit. Receiver operating
      characteristic (ROC) curve was performed to reveal sensitivity, specificity, predictive value
      and diagnostic accuracy of the markers used.
    


Intervention name(s): GCF levels of fetuin A and hsCRP evaluation
Intervention type(s): Diagnostic Test
Intervention description(s): ELIZA kits are used for GCF levels of fetuin A and hsCRP evaluation
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        individuals recruited from outpatient clinic of periodontology department
      
Biospecimen description: 
      GCF samples
Topical CP-690,550 For Chronic Plaque Psoriasis
Condition: Psoriasis
MeSH terms: Psoriasis
Study type: Interventional
Phase: Phase 2

Summary: 
      Study will test effectiveness of an experimental drug applied once or twice daily to two
      psoriasis plaques. Requires 1 clinic visit each week for 5 weeks.
    


Intervention name(s): CP-690,550; CP-690,550; CP-690,550; CP-690,550; CP-690,550; CP-690,550; Placebo Vehicle; Placebo Vehicle
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Topical treatment once daily for 28 days; Topical treatment once daily for 28 days; Topical treatment once daily for 28 days; Topical treatment twice daily for 28 days; Topical treatment twice daily for 28 days; Topical treatment twice daily for 28 days; Topical treatment once daily for 28 days; Topical treatment twice daily for 28 days
Intervention MeSH terms: Tofacitinib
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: chronic plaque psoriasis; topical treatment
Clinical Evaluation of Nanoionomer Filling in Primary Teeth
Condition: Dental Caries
MeSH terms: Dental Caries
Study type: Interventional

Summary: 
      This clinical trial was performed to evaluate the nano-filled resin modified glass ionomer
      (RMGI) -with a brand name of "Ketac Nano"- as a filling material for the treatment of caries
      in primary teeth. Children aged 5-8 years were selected and treated with either Ketac Nano or
      another conventional RMGI called Vitremer. Then, the treated children were evaluated at
      baseline, after one yeat and after two years. The hypothesis to be tested in the present
      study was: The clinical performance of nano-filled RMGI (Ketac Nano) in class I primary
      molars will differ from that of its preceding conventional RMGI (Vitremer).
    

Detailed description: 
      First, shear bond strength of each material to primary molars dentin specimens were measured
      (n=10) using a notched-edge crosshead. Independent sample t-test was used for statistical
      analysis. Then, a split mouth designed clinical trial was performed in which nano-filled
      RMGI; Ketac Nano (KN) and conventional RMGI; Vitremer (VR) were used to restore class I
      cavities of primary molars. Each material group (n=30) was evaluated according to the
      modified United States Public Health Service (USPHS) regarding marginal discoloration,
      marginal adaptation, color match, anatomic form and recurrent caries, at baseline, after one
      year and after two years. Wilcoxon signed- rank test and Chi-square test were used for
      statistical analysis.
    

Intervention name(s): Dental caries was removed from primary molars and was filled with the recent filling material; Ketac Nano.; Dental caries was removed from primary molars and was filled with the conventional filling material;Vitremer
Intervention type(s): Procedure; Procedure
Intervention description(s): Class I carious primary molars were selected. Dental caries was removed and cavities were prepared. The recent nano-filled RMGI filling (Ketac Nano) was used to fill these cavities.; Class I carious primary molars were selected. Dental caries was removed and cavities were prepared. The conventional RMGI filling (Vitremer) was used to fill these cavities.
Intervention MeSH terms: Vitremer
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: nano-filled resin modified glass ionomer; clinical performance; class I; primary teeth; dentin bond strength; Filling of class I
PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs )
Condition: Lymphatic Filariasis; Yaws; Trauma
MeSH terms: Filariasis; Elephantiasis, Filarial; Elephantiasis
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a Pharmacokinetic and Pharmacodynamic study evaluating the safety of co-administering
      Azithromycin alongside the new IDA (Ivermectin, Diethylcarbamazine, Albendazole) combination
      treatment for LF. Individuals will be randomised to receive Azithromycin alone, IDA or
      combination therapy. Clinical and biochemical monitoring for safety will be undertaken. Drug
      levels will be measured in each of the three arms to assess whether combination therapy
      significantly alters drug levels.
    


Intervention name(s): Azithromycin; Albendazole; Ivermectin; Diethylcarbamazine
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Treatment with Azithromycin single dose - weight based dosing max 2gm; Single dose of Albendazole weight based dosing
- 400mg; Ivermectin weight based dosing - max 21mg; Diethylcarbamazine weight based dosing - max 500mg
Other intervention name(s): IDA; IDA; IDA
Intervention MeSH terms: Azithromycin; Ivermectin; Albendazole; Diethylcarbamazine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Pharmacokinetic Interaction Between Maraviroc And Fosamprenavir/Ritonavir In Healthy Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This is will be an open-label, fixed-sequence, multiple dose crossover study in 2 cohorts of
      14 healthy male and/or female subjects, to estimate the effect of maraviroc on the
      pharmacokinetics of amprenavir and ritonavir and fosamprenavir/ritonavir on the
      pharmacokinetics of maraviroc.
    


Intervention name(s): Maraviroc; Fosamprenavir/ritonavir; Maraviroc + Fosamprenavir/ritonavir; Maraviroc; Fosamprenavir/ritonavir; Maraviroc + Fosamprenavir/ritonavir
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): maraviroc 300 mg BID x 5 days; fosamprenavir/ritonavir 700/100 mg BID x 10 days; maraviroc 300 mg BID + fosamprenavir/ritonavir 700/100 mg BID x 10 days; maraviroc 300 mg QD x 5 days; fosamprenavir/ritonavir 1400/100 mg QD x 10 days; maraviroc 300 mg QD + fosamprenavir/ritonavir 1400/100 mg QD x 10 days
Other intervention name(s): Selzentry, Celsentri
Intervention MeSH terms: Ritonavir; Fosamprenavir; Maraviroc
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: maraviroc; fosamprenavir; drug interaction; pharmacokinetics; HIV; AIDS; CCR5; protease inhibitor
Inr Tracking Coumadin Use With Phone App
Condition: Warfarin; Mobile Applications
Study type: Interventional

Summary: 
      This study aims to compare the INR values of the patients followed by face-to-face and
      telephone applications.
    

Detailed description: 
      Warfarin has a narrow therapeutic window. Maintaining the patient's international normalized
      ratio (INR) within the predefined therapeutic range is one of the main challenges of warfarin
      treatment. This study was designed as a randomized controlled experiment. Twelve patients
      living in a distant place were assigned to the experimental group, and 12 patients living
      nearby and followed in the outpatient clinic were assigned to the control group. A Patient
      Information Form and the Adherence to Refills and Medications Scale were used to collect
      data.
    

Intervention name(s): mobile applications with the name "Set My INR"
Intervention type(s): Other
Intervention description(s): The relevant software company assisted in developing the phone application. The language of the application created with the name "Set My INR" is Turkish. The application provided an opportunity for patients to share and communicate with their physician after having the INR value measured in a health institution near their place of residence before coming to the hospital
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Embryotransfer Operator and Pregnancy Rate
Condition: Sterility
MeSH terms: Infertility
Study type: Observational

Summary: 
      Several studies had analyzed the correlation between embryo transfer operator experience and
      implantation, clinical pregnancy, abortion and delivery rate.

      The aim of the present study is determining if the probabilities of embryo implantation and
      pregnancy are associated to the operator performing the embryo transfer.

      This study allows following more than 30 different operators in a global period of 20 years
      with almost 20,000 procedures.
    

Detailed description: 
      Several studies had analyzed the correlation between embryo transfer operator experience and
      implantation, clinical pregnancy, abortion and delivery rate. Until now, the evidences are
      mixed and inconclusive.

      The aim of the present study is determining if the probabilities of embryo implantation and
      pregnancy are associated to the operator performing the embryo transfer.

      The database includes all the fresh embryo transfers, performed between January 1997 and
      December 2016 at Humanitas Fertility Center after IVF-ICSI cycles. Only embryo transfers
      performed by the surgeon on duty for that day ("Gynecologist of the Day") will be included.

      Secondary end point is to evaluate if it is possible to draw a learning curve for transfer in
      terms of pregnancies for the different surgeons.

      The strength of this study relies on the completeness of the preoperative factors and follow
      up and on the vastest dataset in literature that can permit to correct for multiple
      confounders and analyze a wide group of outcomes.
    

Intervention name(s): Embryo transfer
Intervention type(s): Other
Intervention description(s): all the fresh embryo transfers, performed between January 1997 and December 2016 at Humanitas Fertility Center after IVF-ICSI cycles, divided per operator
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        The study database includes all the fresh embryo transfers, performed between January 1997
        and December 2016 at Humanitas Fertility Center after IVF-ICSI cycles. Only embryo
        transfers performed by the surgeon on duty for that day ("Gynecologist of the Day") will be
        included. A wider similar database was used for a previous research.

        Data are collected using an exclusive internal web-based database.
The Effect of Hot Pack Application on Postoperative Ileus Undergoing Surgery for Gynecologic Malignancies
Condition: Postoperative Ileus
MeSH terms: Ileus
Study type: Interventional

Summary: 
      Postoperative ileus (POI), is an extensively known complication characterized by an
      impairment of normal gastrointestinal motor activity after abdominal surgery and may also
      occur after surgery at other sites due to non-mechanical causes. [1]. This clinical asset has
      been linked to prominent perioperative morbidity with the following financial burden owing to
      extended hospitalization [1]. Furthermore, POI can postpone adjuvant treatments, such as
      chemotherapy in patients who went through surgery for cancers.

      Abdominal tenderness and distension, nausea and vomiting, delay in the passage of flatus and
      stool, and intolerance to solid food are the prime symptoms of POI [1-3]. It is generally
      transient, but if prolonged, can cause surgical incision dehiscence, intestinal anastomotic
      fistula, abdominal cavity infection, intestinal ischemia, aspiration pneumonia, and other
      serious complications [4-6]. Hence, many clinicians have focused on averting POI. Many
      studies have analyzed preventive methods, such as preoperative mobilization of the patient,
      adequate pain control, gum chewing, epidural anesthesia, coffee consumption, and motility
      agents such as metoclopramide and alvimopan [7-15]. For all the manifold remedy approaches,
      POI maintains a difficult clinical challenge that compromises the rapid improvement of
      patients who underwent abdominal surgery.

      Recently, thermal attempts have been employs for several situations such as inflammatory
      bowel disease, chronic pelvic pain, and abdominal pain [16]. It may be used in two different
      ways; whole body or local. Local thermal therapy can be carried out by hot pack or paraffin
      [17]. It has been demonstrated that local thermotherapy abate myotonia, enhances circulation,
      and eases pain by expediting the removal of the pain-producing substance. Local thermal
      therapy is widely used for a number of conditions such as pain, nausea, vomiting, and some
      bowel diseases in traditional Chinese medicine [18].
    


Intervention name(s): rubber water bag
Intervention type(s): Other
Intervention description(s): bboiled tap water (80 °C) was put in a rubber water bag with a fluffy cover (Fig. 1), and placed on the patient's abdomen at 3, 6, 9, and 12 h after the surgical procedure for 30 minutes in addition to clinical standard postoperative care (ERAS protocol)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Efficacy and Safety of Litramine in 1 Year Weight Loss Study
Condition: Obesity; Excess Calories; Overweight and Obesity; Weight Loss
MeSH terms: Obesity; Overweight; Body Weight; Weight Loss
Study type: Interventional

Summary: 
      To evaluate the efficacy of Litramine in reducing body weight in the context of an
      energy-restricted diet in overweight and moderately obese subjects
    


Intervention name(s): Litramine; Placebo tablet
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 2 tablets to be taken 3 times a day after meals; 2 tablets to be taken 3 times a day after meals
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Litramine; Opuntia ficus-indica; weight loss
A Study of T3 Therapy in Patients With Hypothyroidism
Condition: Hypothyroidism
MeSH terms: Hypothyroidism
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to test a new thyroid hormone preparation. The thyroid gland
      produces two thyroid hormones: mostly T4 and a smaller amount of T3. Thyroid hormone therapy
      for hypothyroidism or thyroid cancer is generally provided using levothyroxine, which is a
      synthetic form of T4. T4 is converted into the active hormone T3 in the circulation.
      Therefore, some researchers believe that T3 levels in T4-treated patients may be slightly
      lower than in individuals whose own thyroid gland is functioning normally. Symptoms of
      hypothyroidism have been suggested to occur because of this possible T3 deficiency, although
      this is controversial. Studies of T3, added to or substituted for T4 in traditional
      levothyroxine regimens, have generally not shown any benefit of T3. However, it is still
      possible that no benefit is seen because of the short duration of action or "half-life" of
      T3. This short-life makes it necessary to dose T3 twice or three times daily. Despite
      multiple daily doses of T3, T3 levels during its therapy tend to be troubled by peaks and
      troughs. These peaks can be associated with symptoms of excessive thyroid hormone levels.
      This study will look at TSH and thyroid hormone levels following a daily dose of a new
      preparation of T3 that may have longer duration of action than liothyronine. This preparation
      of T3 is called Thyromax® or BCT303. The investigators believe that steady levels of T3 will
      be seen after taking Thyromax®. The investigators believe that in patients with
      hypothyroidism use of Thyromax® in the correct dose will produce normal TSH levels, without
      producing symptoms of too much thyroid hormone. The goal of future studies is to test whether
      Thyromax® may be a potential treatment for hypothyroidism, by comparing it with traditional
      levothyroxine therapy.
    


Intervention name(s): Liothyronine, Sodium
Intervention type(s): Drug
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Effect of Preoperational Hand Massage Anxiety Level And Hemodynamic Variables
Condition: Anxiety; Hemodynamic Instability
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      The study was conducted randomly controlled experimental to determine the effect of hand
      massage applied to pre-operative children on anxiety level and physical symptoms of anxiety.
    

Detailed description: 
      On operation morning, "Child and Parent Introduction Form", "State-Trait Anxiety Inventory
      for Children" were read to and "Physiological Symptoms of Anxiety Inspection Form"
      measurement was done on children in both groups, and their 1st measurement values were
      recorded. Routine treatment and nursing care applications of the service were done
      preoperationally. After the researcher and the children in study group sat on a chair facing
      each other, hand massage procedure, 8 minutes to both hands and a total of 16 minutes hand
      massage was applied with liquid petrolatum. No massage was applied to children in control
      group. Right 16 minutes after the 1st filled forms in each group, "State-Trait Anxiety
      Inventory for Children", "Physiological Symptoms of Anxiety Inspection Form" were read,
      measurement was done and 2nd measurement values were recorded. Furthermore, "Satisfaction
      Evaluation Scale" was marked by those in study group after the massage, and measurement
      values were recorded.
    

Intervention name(s): Hand Massage
Intervention type(s): Other
Intervention description(s): Hand massage procedure, 8 minutes to both hands and a total of 16 minutes hand massage was applied with liquid petrolatum.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Prospective, parallel, two-arm, randomized controlled clinical trial
Masking: Single (Participant)
Primary purpose: Supportive Care
Impact of Co Enzyme Q10 as Adjuvant Therapy to Letrozole on Spermiogram
Condition: Male Reproductive Problem; Infertility, Male
MeSH terms: Infertility; Infertility, Male
Study type: Interventional
Phase: Phase 2

Summary: 
      Worldwide infertility affects about 15 % of reproductive-age couples. In many cases,
      infertility can't be treated, new treatment options with promising value were involved in the
      recent clinical trials.
    

Detailed description: 
      We will evaluate the impacts of adding coenzyme Q10 to letrozole on spermiogram and sex
      hormone in men diagnosed with idiopathic oligo/astheno/ teratozoospermia (iOAT) syndrome.

      The study will include 67 patients which will be randomly separated into two groups, Group
      (A) 29 patients will be treated with letrozole 2.5mg tablet orally twice a week, Group (B) 38
      patient will be treated with a combination of letrozole 2.5 mg tablet orally twice a week
      plus Co-Q10 400mg per day, both groups complete treatment for three months. Semen sample,
      serum FSH, estradiol (E2), and testosterone (T) were analyzed at day one, and at the end of
      one, two, and three months.
    

Intervention name(s): Letrozole tablets; Coenzyme Q10 table
Intervention type(s): Drug; Dietary Supplement
Intervention description(s): letrozole 2.5mg twice weekly for 3 months; Coenzyme Q10 400 mg per day for 3 months
Intervention MeSH terms: Ubiquinone; Coenzyme Q10; Letrozole
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A prospective clinical study. The study initially included 74 patients, on follow-up 7 cases were lost and the final analysis involved 67 cases. These patients were further divided into two groups randomly, group A (29) patients received letrozole 2.5mg twice weekly for 3 months, and group B (38) patients receive letrozole 2.5mg twice a week plus Co Q10 400 mg per day for 3 months.
Patients with idiopathic Oligo-Astheno-Teratozoospermia (iOAT) syndrome were selected during their visit to the specialized center of infertility/ Nahrain University. Before taking part, each subject provided their written, informed consent. The duration of this study was from December 2021 till October 2022.
Masking: None (Open Label)
Primary purpose: Treatment
Topical Arnica and Mucopolysaccharide Polysulfate on Postoperative Pain, Edema and Trismus
Condition: Impacted Third Molar Tooth
MeSH terms: Tooth, Impacted; Trismus; Pain, Postoperative
Study type: Interventional
Phase: Phase 4

Summary: 
      The present study was to evaluate the effect of topical Arnica and MPSP application with
      respect to visual analogue scale (VAS) scores, maximal interincisal opening (MIO) and edema
      values after mandibular impacted third molar removal on days 1, 3, 5 and 10 postoperatively.
      The following null hypotheses of the present research were determined as follows: usage of
      topical agents would not influence i) VAS scores, ii) MIO values, and iii) edema values on
      1st, 3rd, 5th, and 10th days after the mandibular impacted third molar surgery
    


Intervention name(s): : Arnica montana; Mucopolysaccharide polysulfate; Control group
Intervention type(s): Drug; Drug; Other
Intervention description(s): In Arnica group, patients were given an unlabelled tube containing cream to be applicated topically on skin surface of masseteric and submandibular region, 2 cm in length cream for each 8 hours, starting immediately after surgery and continued for 10 days; In Arnica group and MPSP group, patients were given an unlabelled tube containing cream to be applicated topically on skin surface of masseteric and submandibular region, 2 cm in length cream for each 8 hours, starting immediately after surgery and continued for 10 days; In Control group, only standard therapy was performed after surgery
Other intervention name(s): Arnika Krem; Hirudoid Fort Krem 445mg/100g
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: impacted third molar; oral surgery; edema; trismus; pain; postoperative sequelae