bioihbjkbjnl/mcl2 huggingface dataset:
Compare a New Method and Formula as a Guide for the Intubation of a Left-sided Double-lumen Tube
Condition: Therapeutic Procedural Complication
Study type: Observational

Summary: 
      One-lung ventilation (OLV) is required for the most of thoracic surgery to facilitate
      surgical visualization by collapsing the lung. The double-lumen tube (DLT) is the commonly
      used device for OLV. The objective of this study was to compare the accuracy of the distances
      between vocal cords to carina of trachea and formula base on patient's height as a guide for
      the intubation of a Left-sided Double-lumen tube
    

Detailed description: 
      In previous study, investigators found that the distances between vocal cords to carina of
      trachea was a useful predictive method for the intubation of a Left-sided Double-lumen tube.
      However in some hospitals preoperative chest CT scans not contain the vocal cords slice. So
      in this study investigators will compare the accuracy of the distances between the midpoint
      of the thyroid cartilage to suprasternal notch base on body surface measurement add the
      distance between suprasternal notch to carina of trachea according to chest CT and formula
      base on patient's height as a guide for the intubation of a Left-sided Double-lumen tube.
    

Intervention name(s): Measurement; Formula
Intervention type(s): Other; Other
Intervention description(s): The distances between the midpoint of the thyroid cartilage to suprasternal notch base on body surface measurement add the distance between suprasternal notch to carina of trachea according to chest CT; The formula base on patient's height as a guide for the intubation of a Left-sided Double-lumen tube
Observational model: Other
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        1. Age<18 or >70 years

          2. ASA>III; BMI>35kg/m2

          3. Without suspected tuberculosis or systemic infection

          4. Without severe cardiopulmonary disease, preoperative hoarseness and anticipated
             difficult airway
A Comparison of LASIK Outcomes Using Two Femtosecond Lasers
Condition: Myopia; Astigmatism
MeSH terms: Astigmatism
Study type: Interventional

Summary: 
      Comparing LASIK outcomes using two femtosecond lasers
    

Detailed description: 
      Patients will have a comprehensive eye examination once they express an interest in the
      study. This includes a slit lamp examination of the front of the eye and a dilated
      fundoscopic examination of the back of the eye. If there is any pathology noted that would
      exclude the patient from the study, then the investigator will inform the patient and make an
      appropriate referral. Patients deemed appropriate for the study after a comprehensive
      examination including computerized videokeratography can be enrolled. Patients will undergo
      bilateral simultaneous eye surgery. Which eye is treated with the Intralase IFS 150 and which
      eye is treated with VisuMax will be randomized so there is a 50% chance for either eye to
      receive one treatment. Patients will be seen on the day of surgery, post op day one, one
      month, three months, six months and one year. Patients will receive topical antibiotics in
      each eye for one week following the procedure. Patients will receive pred forte 1% ophthalmic
      drops for one week after treatment. Patients will also receive vigamox ophthalmic drops for
      four days after treatment. All of this is within the usual and customary standard of care for
      the treatment of patients undergoing LASIK surgery.
    

Intervention name(s): Intralase IFS150; Visumax
Intervention type(s): Device; Device
Intervention description(s): Intralase flap creation; Visumax flap creation
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Eye to eye comparison
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Femtosecond laser; Visumax; Intralase IFS150; LASIK
Constitutional Delay of Growth and Puberty: Towards Evidence-based Treatment
Condition: Constitutional Delay of Growth and Puberty
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      Boys with constitutional delay of growth and puberty (CDGP) should be offered evidence-based
      effective and safe treatment option. This study compares the effects of low-dose testosterone
      and aromatase inhibitor letrozole on pubertal progression. The hypothesis is that, in boys
      CDGP showing earliest signs of puberty, peroral letrozole (2.5 mg/d for 6 mo) induces faster
      biochemical and clinical progression of puberty as compared to low-dose intramuscular
      testosterone Rx (~1mg/kg/mo for 6 mo). In addition, 10 or more boys who select watchful
      waiting instead of medication will provide background data on the natural progression of
      CDGP, and their data will not be used in primary statistical comparisons.
    


Intervention name(s): Testosterone; Letrozole
Intervention type(s): Drug; Drug
Intervention description(s): 1mg/kg every 4 weeks for 6 months; 2.5mg daily for 6 months. Safety criteria: if testosterone level is above 30nM at 3 months, the dosage is reduced to 2.5mg every other day
Other intervention name(s): Sustanon 250; Letrozole Bluefish; Letrozole Orion; Letrozole Accord; Letrozole Sandoz; Femar
Intervention MeSH terms: Letrozole; Testosterone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Puberty; Constitutional; Delay; Letrozole; Testosterone
Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy
Condition: Hypoxic-Ischemic Encephalopathy
MeSH terms: Brain Diseases; Brain Ischemia; Hypoxia-Ischemia, Brain; Hypoxia
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Perinatal asphyxia-induced brain injury is one of the most common causes of morbidity and
      mortality in term and preterm neonates, accounting for 23% of neonatal deaths globally.
      Although many neuroprotective strategies appeared promising in animal models, most of them
      have failed clinically. Erythropoietin (EPO) is an endogenous cytokine originally identified
      for its role in erythropoiesis. Clinical trial has demonstrated the safety and efficacy of
      recombinant human erythropoietin (r-hu-EPO) in the prevention or treatment of anemia of
      prematurity. To date, there are no reports evaluating possible effects of EPO on neonatal
      HIE.
    

Detailed description: 
      Hypoxic-ischemic encephalopathy of the newborn infant remains a significant socio-economic
      health problem worldwide. Moderate to severe HIE of newborn infants is associated with a high
      rate of death or long-term disabilities. Historically, treatment has been purely supportive
      including stabilizing cardio-respiratory functions and treating convulsions.Recent
      multi-center trials assessing the effects of hypothermia demonstrated improved outcome in
      term neonates with moderate hypoxic-ischemic encephalopathy (HIE). However, hypothermia was
      not effective beyond 6 hrs after brain injury.

      Systemically administered EPO was neuroprotective in neonatal brain injury models. Clinical
      study on adult stroke showed improved outcome. However, treating HIE with EPO raises a series
      of questions such as: i) Can the patient population of this study readily be compared with
      those in the hypothermia trials? ii) What are the pharmacokinetics of EPO, including issues
      of dosage and timing, and does administered EPO cross the blood-brain-barrier? iii) How does
      the effectiveness, side effects and potentials of EPO therapy compare with induced
      hypothermia?
    

Intervention name(s): recombinant human erythropoietin
Intervention type(s): Drug
Intervention description(s): r-hu-EPO were administered either 300 U/kg or 500 U/kg, subcutaneously the first time and then intravenously every other day for 2 weeks.
Other intervention name(s): EPO
Intervention MeSH terms: Epoetin Alfa
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: asphyxia; erythropoietin; neonates
A Double-Blind, Placebo-Controlled Study of Galantamine to Improve Cognitive Dysfunction in Bipolar Disorder
Condition: Bipolar Disorder
MeSH terms: Bipolar Disorder; Cognitive Dysfunction
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to determine if galantamine augmentaion improves cognition in
      euthymic bipolar patients. In addition, the effect of galantamine on clinical measures of
      functioning and psychopathology will also be assessed.
    

Detailed description: 
      The study length is 12 to 24 weeks depending on whether patients enter the crossover. Study
      also involves 3 neuropsychology testings.
    

Intervention name(s): Galantamine; Placebos
Intervention type(s): Drug; Drug
Intervention MeSH terms: Galantamine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Impact of Black Pepper on Energy Expenditure and Substrate Utilization
Condition: Obesity
Study type: Interventional

Summary: 
      As obesity rates worldwide continue to increase, there is a focus on identifying active food
      ingredients which increase metabolic rate which can be used as a dietary supplement in the
      treatment of overweight and obesity. Promising animal and cell studies have suggested a role
      for black pepper and an active component of black pepper, piperine, in energy expenditure.
      However, the effects of black pepper have not been determined in humans. The investigators
      hypothesis if that consumption of 1.5g black pepper (0.5g in each of three meals over one
      day) will result in an elevation in 24-h resting energy expenditure when contrasted to a
      control day (no black pepper, same diet intake).
    


Intervention name(s): 24-hour energy expenditure and substrate utilization
Intervention type(s): Other
Intervention description(s): Subjects spent two x 24-hour periods inside the metabolic chamber at the UNC NRI (black pepper and no pepper control) each separated by one week. Subjects were requested to arrive at the study center each morning in a fasted state (at least 10 hours). During each study day, subjects remained sedentary. All meals were provided and were tailored to each subject's specific energy requirements. Study meals (with the exception of the 1.5g of black pepper) were identical between the black pepper and no pepper control study days.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: black pepper; metabolic chamber; respiratory chamber
First Human Dose Trial of NNC0215-0384 in Subjects With Rheumatoid Arthritis
Condition: Inflammation; Rheumatoid Arthritis
MeSH terms: Arthritis; Arthritis, Rheumatoid; Inflammation
Study type: Interventional
Phase: Phase 1

Summary: 
      This trial is conducted in Europe. The aim of this trial is to describe the safety and
      tolerability of single intravenous (i.v.) and subcutaneous (s.c.) doses of NNC0215-0384 in
      subjects with active rheumatoid arthritis (RA) on background methotrexate (MTX) treatment.
    


Intervention name(s): NNC0215-0384; placebo; NNC0215-0384
Intervention type(s): Drug; Drug; Drug
Intervention description(s): I.v.(intravenous) dose-escalation. Highest dose planned for i.v. administration is 10 mg/kg; Administered i.v.(intravenous) or s.c. (subcutaneous, under the skin).; The s.c. (subcutaneous, under the skin) part will not start until at least two i.v. dose levels have been evaluated for safety and pharmacokinetics. Highest dose planned for s.c. administration is 4 mg/kg
Intervention MeSH terms: Antibodies, Monoclonal
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Short-term Effects of Active Post-training Slider Neural Mobilization
Condition: Healthy Adults
Study type: Interventional

Summary: 
      Jiu Jitsu is a martial art that consists of various techniques that aim to place the opponent
      in submission. It is essentially a ground fight that requires large movement variety, among
      which flexibility is a substantial physical aptitude, required to perform specific positions
      of attack or defence, especially flexibility of the thoracolumbar spine and hamstrings. The
      literature reports that abnormal posterior lower limb neurodynamics may influence hamstring
      extensibility and muscle length, and lead to changes in perception of stretch and pain. The
      objective of the present study is to evaluate the effect of NM, using sliding techniques of
      the sciatic nerve, immediately after Jiu Jitsu training, on HM flexibility of Jiu Jitsu
      practitioners. The hypothesis is that NM sliders applied immediately after training would be
      as effective as an isolated intervention, as demonstrated in soccer players.
    


Intervention name(s): Neural mobilization
Intervention type(s): Other
Intervention description(s): Neural mobilization (NM) is a physiotherapy method aimed at restoring the dynamic balance between the relative movement of neural tissues and surrounding mechanical interfaces, and different techniques are used for the treatment of various compression syndromes as well as other pain conditions, such as back and neck pain (Basson et al., 2017; Ellis and Hing, 2008). The main techniques used are neurodynamic sliders and neurodynamic tensioners, with the tensioning techniques being considered the more aggressive approach, in which the increase in nerve length occurs (Silva et al., 2014). The neurodynamic sliders techniques are gentle maneuvers as they involve nerve lengthening at one joint and simultaneous reduction in its length at an adjacent joint in order to produce sliding movements of neural structures relative to adjacent tissues (Efstathiou et al., 2015).
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of Simethicone on Reducing Bowel Interference During Tubal Resection
Condition: Sterility, Postpartum
MeSH terms: Infertility; Infertility, Female
Study type: Interventional
Phase: Phase 3

Summary: 
      Tubal ligation is an everyday procedure for permanent female sterilization. It is usually
      performed after a vaginal delivery. Minilaparotomy is generally performed by doing small
      incision at infraumbilical area. This minimal access surgery requires adequate operative
      field exposure. Bowel interference, which obscures visualization of the operative field has
      been recognized as one of the major obstacles during this procedure. We found problems while
      doing surgery in small space and one of them is bowel interferance which obscures vision.
      This could lead to prolonged operation and complications. Simethicone is an antifoaming agent
      that use in bowel preparation prior to various procedures including laparoscopy, colonoscopy,
      endoscopy, and open major abdominal operations. Simethicone is proven to break the bubble and
      reduce intraluminal gas. This effect could result in reduction of bowel dilatation that
      interfere with the proper identification of the adnexal area. Benefit of taking simethicone
      prior to do minilaparotomy for tubal resection has not been examined.

      Objectives: To examine the effect of simethicone on reducing bowel interference during
      minilaparotomy for tubal resection.

      Design: A randomized controlled trial in women, age 20-45 years, undergoing postpartum
      sterilization after vaginal delivery at Faculty of Medicine, Chiang Mai University hospital.
      The participants will be randomly assigned into one of two study groups: intervention (taking
      simethicone) and control (not taking simethicone). For the intervention group, each woman
      will take simethicone (80 mg) 2 tablet chewing with water 50 ml at 2-8 hours before surgery.
      Fasting at least 6 hours before surgery. For the control group, the women will receive the
      same standard perioperative care without taking simethicone. The primary outcome measure will
      be surgeon-rated operative difficulty score, which is a visual analog scale based on assess
      from exposure of to the operative field in visual analog scale by surgeon. The secondary
      outcome will be operative time and incidence of intraoperative and postoperative
      complications.
    


Intervention name(s): Simethicone 80 MG
Intervention type(s): Drug
Intervention description(s): Simethicone (Air-X®; 80 mg) 2 tablets chewing with water 50 ml at 2-8 hours before surgery
Intervention MeSH terms: Simethicone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Myeloid-Derived Supressor Cells in Cardiac Surgery Patients
Condition: Insufficiency; Cardiac, Complicating Surgery; Systemic Inflammatory Response Syndrome
MeSH terms: Heart Failure; Systemic Inflammatory Response Syndrome
Study type: Interventional

Summary: 
      Pro- and anti-inflammatory response during the formation of the critical state develops at
      the same time. Because of its balanced or unbalanced systemic inflammation can be either
      aborted or able to lead to multiple organ failure. With regard to sepsis, systemic
      inflammatory response characteristics are well understood, is not achieved in respect of the
      "sterile" inflammation.

      Extracorporeal circulation is a clinical model of systemic inflammatory response due to
      non-physiological activation of tissue factor in the extracorporeal perfusion, the use of
      non-pulsatile circulation mode, intentional / unintentional hypothermia, bacterial
      translocation from the gastrointestinal tract and perfusion deficit.

      We have proved that the monocytes demonstrate suppressor function, which can be a predictor
      of complications from cardiac surgery patients.

      The most important component of the formation of multiple organ failure (MOF) in critically
      ill patients is immunosuppression.

      During the study of experimental and clinical tumor growth process scientists has provided a
      new population of immature myeloid cells (myeloid suppressor cells or suppressor cells of
      myeloid origin, MDSC). Most of the works have been devoted to the role of MDSC in the
      development of tumors, where it has been clearly shown that this cell population has an
      undoubted effect of immune suppression. However, recent studies show that the role of MDSC is
      not limited to cancer process, but extends to chronic or acute inflammation.

      The aim of this study is to determine the role of MDSC in the development of immune
      suppression and complications after heart surgery carried out under cardiopulmonary bypass.
    

Detailed description: 
      The use of MEC systems can be useful to prevent the MDSC activation after cardiac surgery.

      The procedures to modulate the cytokines concentration can be useful to prevent the MDSC
      activation after cardiac surgery.
    

Intervention name(s): minimal extracorporeal circulation (MEC); The cytokines modulations
Intervention type(s): Device; Procedure
Intervention description(s): We should use the modification of extracorporeal circulation to reduce the systemic inflammatory response due to excessive haemodilution, allogenic blood transfusion.; We should use the modification of cytokines by CytoSorb devices and cytokines removal by PMMA membranes during extracorporeal circulation in patients with risk factors of complications (long duration of extracorporeal circulation, re-do procedures and other)
Other intervention name(s): CytoSorb devices,
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Immune Suppression, Inflammatory Response, Cardiac Surgery
Cardiovascular Function and Physical Activity in COVID-19
Condition: Coronavirus 2019
MeSH terms: COVID-19; Coronavirus Infections
Study type: Interventional

Summary: 
      The purpose of this study is to a) assess how coronavirus 2019 (COVID-19) affects cardiac
      function in middle age and older adults and b) assess if a physical activity intervention
      (increased daily step count by 2,000) can affect cardiac function in a population with a
      history of COVID-19.
    

Detailed description: 
      Cardiac function will be assessed by obtaining arterial stiffness, comprehensive
      echocardiography measurements and haemodynamic monitoring. Arterial stiffness will assess
      primarily pulse wave velocity (PWV) and echocardiography. Graded cardiopulmonary exercise
      stress testing coupled with non-invasive gas exchange and haemodynamic monitoring will also
      be performed. Physical activity will be assessed objectively using pedometers and
      accelerometry. Quality of life, sleep/ circadian rhythm, fatigue, anxiety and depression will
      be measured using the validated Short-Form-36 (SF-36) questionnaire, Pittsburgh Sleep scale
      (PSQI), Chalder fatigue (CF) scale and the Depression, Anxiety and Stress Scale (DASS-21).
    

Intervention name(s): Active-at-home-HF
Intervention type(s): Behavioral
Intervention description(s): Increase daily step count by 2,000 and weekly telephone calls.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Coronavirus 2019; Cardiovascular System; Arterial Stiffness; Echocardiography; Cardiopulmonary exercise stress testing; COVID-19