bioihbjkbjnl/mcl2 huggingface dataset:
Measure the Meridian Energy Change of Terminal Hospice Patient Via Meridian Energy Analysis Device
Condition: Hospice; Survival; Alternative Medicine; Skin Electric Conductance
Study type: Interventional

Summary: 
      In the hospice ward, there are lots of suffered hospital patients with multiple physical
      discomfort related to terminal disease. Investigators want to use an objective measure
      instrument to monitor the effects of complementary and alternative medicine and clinical
      symptoms. First, investigators use the Meridian Energy Analysis Device (MEAD) to measure the
      bilateral 12 Yuan points (primary points) of terminal hospice patients. It provides the
      prediction value between terminal disease and the change of different meridian energy.
      Besides, the meridian energy value maybe predict the survival period. Then, the intervention
      of complementary and alternative medicine can also monitor via MEAD.
    

Detailed description: 
      In the hospice ward, there are lots of suffered hospital patients with multiple physical
      discomfort related to terminal disease. It may be caused by cancer or multiple kinds of organ
      failure. The terminal hospital patients have symptoms such as pain, dyspnea, fatigue, nausea,
      vomiting, poor appetite, constipation, ileus or edema…, etc. Investigators want to use an
      objective measure instrument to monitor the effects of complementary and alternative
      medicine.

      First, investigators use the Meridian Energy Analysis Device (MEAD) to measure the bilateral
      12 Yuan points (primary points) of terminal hospice patients (divided to cancer, multiple
      kinds of organ failure). It provides the prediction value between terminal disease and the
      change of different meridian energy. Besides, the meridian energy value maybe predict the
      survival period. Then, investigators use the intervention of complementary and alternative
      medicine (like infrared lamp and acupressure…, etc.) to improve the quality of life in the
      terminal hospice patients. Also, investigators will use the Meridian Energy Analysis Device,
      pain scale, vital signs and quality of life scale (SF-36) to evaluate the effects of
      complementary and alternative medicine.
    

Intervention name(s): Infrared Lamp and Acupressure
Intervention type(s): Behavioral
Intervention description(s): Measure the ankle and wrist acupoints skin conductance to evaluate the basic condition of terminal hospice patients. Then investigators use the infrared lamp and acupressure(tender points, PC6 and ST36 for one minutes) for our patient for the cold limbs, pain control and constipation problems.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: skin electric conductance; survival period; complementary and alternative medicine
Comparison of the Bulb Aspirator to a Nasal Oral Aspirator in the Treatment of Bronchiolitis
Condition: Bronchiolitis; Aspirator
MeSH terms: Bronchiolitis
Study type: Interventional

Summary: 
      The investigators aim to compare the standard bulb aspirator with that of a nasal oral
      aspirator. The hypothesis is that use of a nasal oral aspirator is more effective at removing
      nasal secretions in the treatment of bronchiolitis as measured by a predicted 50% decrease in
      the rate of unscheduled bronchiolitis return visits. The primary endpoint will be the number
      of unscheduled bronchiolitis return visits; secondary endpoints will include measurements of
      oral intake, respiratory relief, parental device preference and adverse events.
    

Detailed description: 
      This study will be a single center, single blind, randomized controlled trial in the
      pediatric emergency department (ED) at Dell Children's Medical Center of Central Texas
      (DCMC). An ED discharge diagnosis of bronchiolitis will trigger patients to be randomized to
      receive a bulb aspirator or nasal oral aspirator for home secretion management use. Prior to
      dispensing the randomized aspirator, a pre-distribution questionnaire will be administered.
      Additionally, patients will receive a diary to complete for 3 days post ED discharge.
      Research personnel will call families on day 4 as a reminder to return the diary and again on
      day 14 to obtain a verbal post-study questionnaire. Research personnel will perform chart
      review on all patients looking for unscheduled patient return visits for bronchiolitis.
    

Intervention name(s): NeilMed Naspira
Intervention type(s): Device
Intervention description(s): NeilMed Naspira is a nasal-oral aspirator
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Naspira; Suctioning; Nasal suction device; Children
Alberta Hip Improvement Project
Condition: Arthroplasty, Replacement, Hip
Study type: Observational

Summary: 
      A study to determine the effectiveness and safety of the use of metal-on-metal hip
      resurfacing (for example the birmingham hip) when compared to conventional total hip
      replacement.
    

Detailed description: 
      This study is designed to provide orthopedic surgeons and decision makers with evidence-based
      health measures for patients that are treated by orthopedic surgeons for degenerative joint
      disease of the hip in Alberta. This study is provincial initiative to determine whether new
      alternative hip bearing surfaces improve patient outcomes and/or decrease health resource
      utilization in patients with degenerative joint disease of the hip in Alberta. The primary
      objective is to compare time to revision for patients receiving alternative hip bearing
      surfaces to patients receiving conventional total hip replacements. Secondary objectives are
      to evaluate long-term safety; to evaluate costs; to determine if alternative hip bearing
      surfaces improve patient function; to develop evidence base guidelines for the implementation
      of alternative hip bearing surfaces in Alberta; do develop a modal to assess other
      technologies and health advances; to develop an Alberta HIP registry
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Males between the ages of 18-65 and females between the ages of 18-55
      
Biospecimen description: 
      Blood samples retained for cobalt and chromium metal ion level analysis on select cohort.
    
Keywords: Prospective; Conventional therapy; Registry; Metal-on-metal; Ceramic-on-ceramic; Hip Arthroplasty
Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder
Condition: Tourette's Disorder
MeSH terms: Tourette Syndrome
Study type: Interventional
Phase: Phase 3

Summary: 
      The goal of the current study is to determine efficacy and safety of once-weekly aripiprazole
      in reducing Total Tic Severity (TTS) score in children and adolescents with Tourette's
      Disorder.
    


Intervention name(s): Aripiprazole; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Aripiprazole tablet administered orally once a week.; Aripiprazole-matching placebo tablet administered orally once a week.
Other intervention name(s): ABILIFY
Intervention MeSH terms: Aripiprazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Tourette's Disorder; Tic disorders
Evaluation of the Tolerance and Safety of a New Partly Fermented Anti-regurgitation Infant Formula
Condition: Regurgitation, Gastric
MeSH terms: Laryngopharyngeal Reflux
Study type: Interventional

Summary: 
      A randomised, controlled, double-blind trial to evaluate the tolerance and safety of a new
      partly fermented anti-regurgitation infant formula containing prebiotics and locust bean gum
      in infants with regurgitation.
    


Intervention name(s): Anti-regurgitation infant formula
Intervention type(s): Other
Intervention description(s): Anti regurgitation infant formula
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS)
Condition: Ankylosing Spondylitis(AS)
MeSH terms: Spondylitis; Spondylarthritis; Spondylitis, Ankylosing
Study type: Interventional
Phase: Phase 4

Summary: 
      1. To determine the effect of Golimumab treatment on the number and function of Endothelial
           Progenitor Cells (EPCs) in Ankylosing Spondylitis(AS) patients as a possible mechanism
           for the effect of this treatment on endothelial function.

        2. To ascertain the effect of Golimumab treatment on , carotid intima-media thickness,
           vascular stiffness in Ankylosing Spondylitis(AS) patients as measured by pulse wave
           velocity (PWV) and Augmentation index (AIx).

        3. To assess the clinical efficacy of Golimumab in Chinese Ankylosing Spondylitis(AS)
           patients according to ASAS response criteria at month 3, 6 and 12.

        4. To perform cost-effectiveness and cost-utility analyses of the Golimumab in Ankylosing
           Spondylitis(AS) patients, using clinic-base data.
    

Detailed description: 
      This study will provide important data on the pathogenesis of vascular damage and possible
      mechanism by which potent anti-inflammatory treatment may reduce cardiovascular risk in
      Ankylosing Spondylitis(AS) patients.

      Fifty patients with Ankylosing Spondylitis(AS) will be randomized to receive either Golimumab
      or Placebo for 12 months. Patients randomized to Placebo with worsening disease activity
      (failure to achieve Assessment of SpondyloArthritis international Society (ASAS20)) at week
      24 will be permitted to escape to open-label Golimumab. Clinical assessment, intima-media
      thickness, vascular stiffness and endothelial progenitor cells will be performed at baseline,
      6 and 12 months.
    

Intervention name(s): Simponi; 0.9ml sodium chloride
Intervention type(s): Drug; Other
Intervention description(s): Golimumab 50mg monthly; 0.9ml sodium chloride
Other intervention name(s): Golimumab
Intervention MeSH terms: Golimumab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Ankylosing Spondylitis; Golimumab; Simponi; Anti-TNF alpha; EPCs; Vascular stiffness
Enhancing Exercise Participation in Overweight Adults
Condition: Weight Loss
MeSH terms: Overweight; Weight Loss
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The purpose of this study is to examine whether behavioral strategies implemented during the
      adoption versus the maintenance periods of weight loss to enhance exercise participation in
      overweight adults are more effective than a standard behavioral intervention.
    


Intervention name(s): behavioral weight loss
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Patients Decision-making in Rotator Cuff Surgery
Condition: Rotator Cuff Disease
Study type: Observational

Summary: 
      The objective of this study was to evaluate the effect on patient treatment decision-making
      if information was given based on the benefit or on the side effect in rotator cuff
      disorders.
    


Intervention name(s): questionnaire
Intervention type(s): Other
Intervention description(s): fulfillment of questionnaire
Observational model: Case-Crossover
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        patients with diagnosis of rotator cuff tears documented by MRI
HIV-1, Insufficient Sleep and Vascular Endothelial Dysfunction
Condition: HIV-1
MeSH terms: Sleep Deprivation
Study type: Interventional

Summary: 
      The investigators hypothesize that chronic insufficient sleep is associated with diminished
      endothelium-dependent nitric oxide-mediated vasodilation and tissue-type plasminogen
      activator release in anti-retroviral (ART)-treated HIV-1-seropositive adults. Furthermore,
      the investigators hypothesize that the postulated diminishment in endothelial vasodilator and
      fibrinolytic function with insufficient sleep will be due, at least in part, to increased
      oxidative stress. Moreover, increasing sleep duration and improving sleep quality will
      increase both endothelium-dependent nitric oxide-mediated vasodilation and endothelial
      tissue-type plasminogen activator release in ART-treated HIV-1-seropositive adults. Increases
      in endothelial vasodilator and fibrinolytic function will be due, at least in part, to
      reduced oxidative stress.
    


Intervention name(s): Individualized Targeted Sleep
Intervention type(s): Behavioral
Intervention description(s): The investigators will employ an 8-week individualized targeted sleep intervention. Individualized targeted interventions have the advantage of improving adherence, reducing attrition, and making the strategy personally meaningful.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Sleep
Assessment of the Therapeutic Utility of hMG-HP
Condition: Sterility
MeSH terms: Infertility
Study type: Observational

Summary: 
      To assess the effectiveness of a protocol of ovarian hyperstimulation with urinary
      gonadotrophins, to achieve clinical pregnancy in females undergoing IVF.

      Study hypothesis: to assess the effectiveness of a protocol of urinary gonadotrophins
    


Intervention name(s): hMG-HP
Intervention type(s): Drug
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Females affected by sterility able to undergo IVF
Effect of Core Stability Excercises Program on Reaching in Children With Cerebral Palsy
Condition: Cerebral Palsy
MeSH terms: Cerebral Palsy
Study type: Interventional

Summary: 
      Purpose of the study:

      To evaluate effect of core stability exercises program on upper limb reaching in children
      with spastic hemiparetic cerebral palsy.
    

Detailed description: 
      Thirty spastic hemiparetic cerebral palsied children of both sexes will be selected from
      General hospitals and private centers in El-Minia government with the following criteria:

        1. The age of the selected children ranged from 3 To 6 years old.

        2. Degree of spasticity is ranging from 1 to 1+, according to modified Ashworth scale

        3. Children in study group will be treated using core stability exercises program in
           addition to traditional program and children in the control group will be treated using
           traditional physical therapy program.

        4. Trunk control measurement scale and pediatric reach test will be used to evaluate each
           child individually before and after 6 successive weeks of treatment, three times per
           week.
    

Intervention name(s): Core stability exercises program; Traditional physical therapy program
Intervention type(s): Procedure; Procedure
Intervention description(s): Strengthening to the trunk muscles; Neurodevelopmental training excercises
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: study group and control group
Masking: None (Open Label)
Primary purpose: Treatment
Music Therapy in Sickle Cell Transition Study
Condition: Sickle Cell Disease
MeSH terms: Anemia, Sickle Cell
Study type: Interventional

Summary: 
      The purpose of this study is to investigate the effects of the BEATS Music Therapy Program on
      the self-efficacy, trust, knowledge, and adherence of young adult patients with sickle cell
      disease during transition.

      Primary Hypotheses:

      Compared to baseline, young adult patients with sickle cell disease who receive the music
      therapy interventions will report:

        1. Higher sickle cell self-efficacy as measured by the Sickle Cell Self Efficacy Scale
           (SCSES),

        2. Higher trust in health care providers as measured by the Wake Forest Trust in the
           Medical Profession Scale, and

        3. Higher sickle cell disease knowledge as measured by the Seidman Sickle Cell Knowledge
           Quiz.

      Secondary Hypotheses

      1. Compared to the one year prior to the study period, young adults with sickle cell disease
      who receive the music therapy interventions will have a higher rate of adherence to clinic
      appointments during the one-year study period.

      Additional Questions

        1. Do music therapy interventions influence attendance to scheduled blood transfusions?

        2. Do music therapy interventions influence the rate of hospital utilization as measured by
           Emergency Department visits, Acute Care Clinic visits, and admissions during the study
           period compared to the previous year?

        3. Do music therapy interventions influence adherence to hydroxyurea therapy for patients
           receiving hydroxyurea as measured by change in mean corpuscular volume (MCV) during the
           study period?

        4. Do music therapy interventions influence adherence to iron chelation therapy for
           patients receiving iron chelation therapy as measured by ferritin count during the study
           period?
    


Intervention name(s): Music Therapy
Intervention type(s): Behavioral
Intervention description(s): During the educational music therapy intervention, member(s) of the Adult Sickle Cell Disease team will share with the patients the medical information pertinent to the appointment, ask health related questions of the patients and respond to any pertinent inquiries. The Music Therapist will then engage the patients and member(s) of the Adult Sickle Cell Disease team in a music therapy intervention designed to teach and reinforce the skills and knowledge presented. These music therapy interventions may include but are not limited to original songs/rap/instrumental playing, vocal and/or instrumental improvisation, patient-contributed lyrics, mnemonics, and stress and pain reducing strategies. The music therapy interventions will be tailored to best convey the educational message.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
3D Printing in Airway Anatomy and Bronchoscopy Education
Condition: Satisfaction, Personal
Study type: Interventional

Summary: 
      The main purpose of this study is to use 3D printing technology to make a human anatomical
      bronchial tree model, which is applied in medical education for medical students and students
      of the department of respiratory therapy. Most of the clinical teaching material is expansive
      and inaccessible. To promote accessibility of anatomy models and student learning effects in
      our school and hospital, we use the 3D printing technology to print bronchial tree model and
      apply it to anatomy and bronchoscopy education.

      The present study expects some benefits that the use of printed bronchial trees for anatomy
      and bronchoscopy education. For example, it can reduce the cost of anatomy instruction, let
      students have their own anatomical model, and make the learning no longer limited to the
      anatomical classroom.
    

Detailed description: 
      Three-dimensional (3D) printing is a technology used for the rapid production of customized
      physical objects. Bronchoscopy is a well-established, relatively safe procedure for both
      diagnostic and therapeutic interventions for a variety of pulmonary diseases. In this study,
      to enhance the quality of airway anatomy education and bronchoscopy training, we used 3D
      printing to develop a 3D bronchial tree model as a high-fidelity simulator for bronchoscopy
      and demonstrated its validity. We designed a 3D bronchial tree model containing 12 detachable
      parts and 11 adapter rings.
    

Intervention name(s): 3D bronchial tree model
Intervention type(s): Other
Intervention description(s): A detachable 3D printed bronchial tree model
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Longitudinal Observation of Insulin Requirements and Sensor Use in Pregnancy
Condition: Type 1 Diabetes Mellitus; Pregnancy in Diabetics
MeSH terms: Pregnancy in Diabetics; Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Observational

Summary: 
      The overall goal of this study is to enroll pregnant women with type 1 diabetes and follow
      their glycemic outcomes prospectively throughout pregnancy and into the post-partum period.
      The investigators anticipate that when compared to subjects using an Artificial pancreas
      system (AP) as part of a future protocol, this comparator group of subjects undergoing usual
      care will exhibit less time in target continuous glucose monitoring (CGM) glucose range
      defined as 63-140 mg/dL and an increased duration of hypoglycemia with CGM glucose <63 mg/dL.
    

Detailed description: 
      This is an observational study. Data collected will include records of continuous glucose
      monitoring (CGM) based glucose, insulin delivery, self-monitoring of blood glucose (SMBG),
      and maternal and fetal outcomes from pregnant women with type 1 diabetes. These data will be
      used to: (1) develop and refine algorithms for an AP system tailored to the needs of pregnant
      women with type 1 diabetes, (2) to serve as a comparator group for concurrent AP protocols,
      (3) describe Dexcom G6 CGM data throughout the pregnancy, and (4) describe insulin changes
      which occur in pregnancy.
    

Intervention name(s): Dexcom G6 CGM
Intervention type(s): Device
Intervention description(s): All women in the study will be given Dexcom G6 CGM and a study glucometer.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Pregnant women 18 years of age or older with T1D using an insulin pump
      
Keywords: type 1 diabetes; pregnancy; continues glucose monitoring; artificial pancreas
The Effect of Reiki Application on Stress and Anxiety Levels
Condition: Stress
Study type: Interventional

Summary: 
      The aim of this study is to determine the effect of reiki practice on stress and anxiety
      levels in nurses.
    

Detailed description: 
      It was a randomized controlled trial. Reiki was applied to the participants in the
      experimental group twice a week for two weeks. No intervention was applied to the
      participants in the control group.
    

Intervention name(s): Reiki attempt
Intervention type(s): Other
Intervention description(s): Four reiki sessions were applied twice a week, on the same days of the week, lasting 25-35 minutes each.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: Anxiety; Nursing; Reiki; Perceived stress