Study of the Effects of Supplements on Eye Disease in Participants From the Age-Related Eye Disease Study
Condition: AMD; Age- Related Macular Degeneration
MeSH terms: Macular Degeneration; Eye Diseases
Study type: Observational

Summary: 
      Background:

      - The Age-Related Eye Disease 2 Study (AREDS2) looked at two eye diseases. These were
      age-related macular degeneration (AMD) and cataracts. Participants in that study took
      supplement pills and some participants had additional pictures taken of their eyes. That
      study is now over. Researchers want to do a follow-up study after participants finish taking
      the pills, to see if they cause long-term effects on AMD. This study will be combined with
      follow-up visits of the AREDS2 study if possible.

      Objectives:

      - To learn more about the effect of oral supplements on AMD.

      Eligibility:

      - People who completed the AREDS2 study.

      Design:

        -  Participants will have up to 2 study visits over 6 18 months.

        -  Each visit will last up to 5 hours. The visits will be combined with annual follow-up
           visits in the AREDS2 study if possible.

        -  At each visit, participants will undergo an eye exam and photography.

        -  The eye exam includes testing sight, measuring eye pressure, and checking eye movements.
           To examine the inside of the eye, the pupil will be dilated with eye drops.

        -  Photographs of the inside of the eye may be taken during the eye exam and while the eyes
           are dilated.

        -  A contact lens may be placed on the eye briefly to look at the retina at the back of the
           eye.
    

Detailed description: 
      The Age Related Eye Disease Study 2 (AREDS2) was a multicenter Phase III randomized clinical
      trial designed to assess the effects of oral supplementation of high doses of macular
      xanthophylls (lutein and zeaxanthin) and/or omega-3 LCPUFAs as a treatment for age-related
      macular degeneration (AMD), cataract and moderate vision loss. In addition to this objective,
      the study provided information on the clinical course, prognosis, and risk factors for
      development and progression of both AMD and cataract. Other study goals included the
      evaluation of eliminating beta-carotene and/or reducing zinc in the original AREDS
      formulation on the progression and development of AMD. AREDS2 also sought to validate the
      fundus photographic AMD scale developed from AREDS.

      Inclusion criteria in AREDS2 resulted in the enrollment of participants with intermediate
      AMD, defined by the presence of large drusen, with and without additional pigmentary changes.
      Owing to the longitudinal nature of AREDS2 study, anatomical features of AMD in study
      participants can be monitored and characterized as a function of time to further understand
      the steps in AMD progression. Spectral domain OCT (SDOCT) is a non-invasive imaging
      technology that has the speed and resolution to image fine structures such as drusen and the
      photoreceptor layers. With annotation and processing of three-dimensional SDOCT scans, focal
      AMD pathology such as drusen can be mapped and monitored over time. The AREDS2 Ancillary
      SDOCT Study (A2A SDOCT) added the use of novel higher resolution three-dimensional OCT
      retinal imaging at four AREDS2 study centers to examine 400 of the participants in the AREDS2
      clinical trial.

      The purpose of this ancillary AREDS2 study (study acronym: A2A_SDOCT) is to identify whether
      measurable AMD pathology (drusen, photoreceptor layer thickness, early findings of geographic
      atrophy (GA) or neovascularization) imaged by spectral domain optical coherence tomography
      (SDOCT) can predict progression of AMD and vision loss. The A2A_SDOCT study began as an
      ancillary AREDS2 study; however AREDS2 had stopped gathering participant data on October 31,
      2012 and will be terminated soon. This extension study is needed to complete the AREDS2
      dataset by collecting images at one or two additional time points, as the study started over
      a year behind the AREDS2 study. The data collection period for the extension will end April
      30, 2014. Data analysis will conclude by October 31, 2014. All AREDS2 study procedure
      guidelines for data collection will be followed, as described below, even though this visit
      falls outside the AREDS2 study timeline.
    

Time perspective: Prospective
Keywords: Age-Related Macular Degeneration (AMD); AMD