Evaluation of GCB-70 in Overweight Subjects
Condition: Weight Loss
MeSH terms: Overweight; Weight Loss
Study type: Interventional

Summary: 
      Clinical evaluation of GCB-70 in overweight subjects: An Add-On Study
    

Detailed description: 
      In recent years the prevalence of obesity has increased reaching epidemic levels. Obesity can
      be defined as excess accumulation of body fat arising from a sustained or a periodic positive
      energy balance that is when energy intake exceeds energy expenditure. Overweight and obesity
      is based on Body Mass Index (BMI) Accordingly to the World Health Organization (WHO)
      classifies individuals with BMI 25-29.99 kg/m2 as overweight while individuals with BMI≥ 30
      kg/m2 are termed obese. Apart from being a major contributor to chronic disease burden and
      mortality, obesity-particularly abdominal obesity, is also closely related to the metabolic
      syndrome, a cluster of diseases that encompasses the following conditions Dyslipidemia,
      Hypertension Glucose intolerance and insulin resistance.Abdominal obesity The World Health
      Organization predicts there will be 2.3 billion overweight adults in the world by 2015, and
      more than 700 million of them will be obese. Worldwide obesity has more than doubled since
      1980. In 2008, 1.5 billion adults, 20 years of age and older, were overweight. Of these, over
      200 million men and nearly 300 million women were obese. Over 65% of the world population
      lives in countries where overweight and obesity kills more people than underweight .

      Overweight and obesity have become a serious health concern . Diﬀerent weight management
      strategies are presently utilized and a variety of weight loss supplements sold as "slimming
      aids" are readily available. However, the eﬃcacy of some of these food supplements remains
      uncertain. With the high cost of prescription weight loss drugs and the fear of side effects,
      the general public is turning to nutraceuticals. One such supplement is the green coﬀee
      extract (GCE).GCE is present in green or raw coﬀee.

      Coffee (Coffea L.) is the world's favourite beverage and the second-most traded commodity
      after oil. In 2009/10 coffee accounted for exports worth an estimated US$ 15.4 billion, when
      some 93.4 million bags were shipped, with total coffee sector employment estimated at about
      26 million people in 52 producing countries. Arabica coffee (Coffea arabica L.) and robusta
      coffee (C. canephora Pierre ex A.Froehner) are the two main species used in the production of
      coffee. 66% of the world production mostly comes from Coffea arabica L. and 34% from Coffea
      canephora. Coffee belongs to family Rubiaceae in the genus Coffea.

      GCB-70 is obtained from raw seeds or beans of Coffee. In producing the normal coffee for
      sale, the berries are roasted to produce the traditional beverage. However, no roasting is
      done for green extract so as to preserve important components
    

Intervention name(s): GCB-70
Intervention type(s): Dietary Supplement
Intervention description(s): green coffee bean extract
Intervention model: Single Group Assignment
Intervention model description: open level
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Obesity, green coffee bean extract, weight management