bioihbjkbjnl/mcl2 huggingface dataset:
Oxytocin Pathways and the Health Effects of Human-Animal Interaction
Condition: HAI
Study type: Interventional

Summary: 
      This study investigates the roles of oxytocin and vasopressin in human-animal interaction.
      Children will participate in three conditions involving friendly interactions with dogs, or
      play with toys at a university laboratory.
    

Detailed description: 
      Oxytocin (OT) and arginine vasopressin (AVP) are neuropeptides that play critical roles in
      social behavior, cognition, stress physiology, and physical health. OT is released in adult
      humans and dogs during affiliative forms of human-animal interaction (HAI), and HAI
      attenuates AVP release in dogs. Thus, HAI may provide a safe and effective approach for
      stimulating endogenous OT release, and inhibiting endogenous AVP activity. The investigators
      will recruit a sample of typically developing 8-10 year old children who will engage in
      structured HAI sessions with a familiar companion dog or unfamiliar dog, compared to a
      nonsocial control condition.
    

Intervention name(s): Pet dog; Unfamiliar dog; Nonsocial control
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Children will interact freely with their pet dog for 25 minutes.; Children will interact freely with an unfamiliar dog for 25 minutes; Children will play with age-appropriate toys/games for 25 minutes.
Intervention model: Single Group Assignment
Intervention model description: Within-subjects, 3 conditions, order counterbalanced across participants
Masking: Single (Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Oxytocin; Vasopressin; Cortisol; Human-animal interaction
Topical Avastin for Treatment of Corneal Neovascularization
Condition: Corneal Neovascularization
MeSH terms: Corneal Neovascularization; Neovascularization, Pathologic
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine the effectiveness and safety of Topical Bevacizumab
      (Avastin) for treatment of corneal neovascularization.
    

Detailed description: 
      Primary outcomes measures included neovascular area (NA), defined as the area of the corneal
      vessels themselves; vessel caliber (VC), defined as the mean diameter of the corneal vessels;
      and invasion area (IA), defined as the fraction of the total cornea into which the vessels
      extend. The occurrence of ocular and systemic adverse events was closely monitored throughout
      the course of the study.
    

Intervention name(s): Topical Avastin 1%
Intervention type(s): Drug
Intervention description(s): Avastin (bevacizumab) 1%
Other intervention name(s): bevacizumab
Intervention MeSH terms: Bevacizumab
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of MK0524A on Flushing Caused by Niacin (0524A-056)
Condition: Flushing
MeSH terms: Flushing
Study type: Interventional
Phase: Phase 3

Summary: 
      The primary objective of the study is to assess the effects of MK0524A in reducing flushing
      associated with niacin.
    


Intervention name(s): MK0524A, /Duration of Treatment : 4 Weeks; Comparator : niacin /Duration of Treatment : 1 Weeks
Intervention type(s): Drug; Drug
Intervention MeSH terms: Niacin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment
Condition: Cognitive Impairment
MeSH terms: CADASIL; Cognitive Dysfunction
Study type: Interventional
Phase: Phase 2

Summary: 
      This is an 18-week, prospective, multi-center, randomized, double-blind, placebo-controlled,
      (1:1) parallel-group study.
    


Intervention name(s): Aricept
Intervention type(s): Drug
Intervention MeSH terms: Donepezil
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Sensorimotor Training and Gait in Diabetic Polyneuropathy
Condition: Diabetic Peripheral Neuropathy
MeSH terms: Peripheral Nervous System Diseases; Diabetic Neuropathies
Study type: Interventional

Summary: 
      Diabetic peripheral neuropathy is a common chronic complication of diabetes mellitus which
      results in high public health costs and has a huge impact on patients' quality of life. It
      leads to sensory and motor deficits, which often result in mobility-related dysfunction, and
      alterations in gait characteristics. These alternations in gait performance cause increase in
      the risk of fall, which has the strongest association with symptoms of depression in patients
      with diabetes. However, little is known about possible treatment strategies for improving
      gait ability and reduce risk of fall in patients with diabetic neuropathy. So, the purpose of
      this study will be to investigate the effect of sensorimotor training on ankle muscle
      strength, gait and quality of life in patients with diabetic peripheral neuropathy.

      To determine if there is an effect for sensorimotor training on gait, ankle muscle strength
      and quality of life in patients with diabetic peripheral neuropathy, the patient will be
      assessed before and after 6 weeks of treatment by measurement of ankle muscles strength using
      isokinetic dynamometer, measurement of different spatiotemporal gait parameters using gait
      trainer instrument , and assessment of quality of life of the patients using HRQL
      questionnaire (SF-36) before and after the treatment sessions.
    


Intervention name(s): sensorimotor training
Intervention type(s): Other
Intervention description(s): Sensorimotor exercises progressed from stable surfaces to unstable surfaces, training gait in a line (tandem walk or walking straight) followed by gait including change in directions, gait without obstacles to gait with obstacles, change in the support base (feet apart and then together), physical exercises with eyes opened and closed, always respecting the functional capacity of each patient and progressively increasing the difficulty of each exercise. To help the training, cones, balance board, bars, mats and a mini-trampoline will be used. According to the patient progress, the exercises will be combined, generating circuits
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Comparison Between Cisatracurium and Rocuronium in Terms of Recovery of the Muscular Strength in the Postoperative Phase After Surgery and General Anaesthesia
Condition: Postoperative Residual Curarization; Residual Neuromuscular Block
MeSH terms: Delayed Emergence from Anesthesia
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to determine the incidence of post-operative residual
      curarization in our patients and to determine if Cisatracurium and Rocuronium behave
      differently from each other in terms of residual curarization.
    


Intervention name(s): Cisatracurium; Rocuronium
Intervention type(s): Drug; Drug
Intervention description(s): Cisatracurium (Nimbex):
initial dose: 0.2 mg/kg
maintaining dose: 0.1 mg/kg (repeated anytime TOF-count reaches 2 twitches); Rocuronium (Esmeron):
initial dose: 0.6 mg/kg
maintaining dose: 0.15 mg/kg (repeated anytime TOF-count reaches 2 twitches)
Intervention MeSH terms: Rocuronium; Cisatracurium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Postoperative residual curarization; Residual neuromuscular block; Complications; Postoperative; Neuromuscular function; Neuromuscular block
Virtual Parental Presence on Induction
Condition: Anxiety; Surgery
Study type: Interventional

Summary: 
      Our goal in this study is to investigate the feasibility and acceptability of virtual
      parental presence of parents on anxiety in children at induction of anesthesia at Cincinnati
      Children's Hospital, an institution whose use of parental presence on induction is deeply
      ingrained in our culture, and to determine the impact of coaching of parents either prior to
      arrival at the hospital vs. on the day of surgery on efficacy of virtual parental presence on
      induction. Our primary hypothesis is that virtual PPIA is both feasibile for the smooth
      induction of general anesthesia and is acceptable to parents, patients, and anesthesia
      providers at our isntutition. Our secondary hypothesis is that the coaching of parents prior
      to virtual PPIA enhances the effect of video parental presence at induction of anesthesia on
      children's anxiety and that coaching prior to arrival at the hospital will allow for
      increased ease and use of this technique.
    


Intervention name(s): Use of Facetime with child and parents during induction
Intervention type(s): Other
Intervention description(s): Families will be able to use Facetime with their child when the child is taken to the operating room
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Esmolol Infusion in Patients Undergoing Craniotomy
Condition: Cerebral Arterial Disease; Cerebral Aneurysm
MeSH terms: Intracranial Aneurysm; Cerebral Arterial Diseases; Aneurysm
Study type: Interventional
Phase: Phase 3

Summary: 
      Anesthesia techniques that minimize anesthetic requirements and their effects may be
      beneficial. Esmolol, a short acting hyperselective β-adrenergic blocker is effective in
      blunting adrenergic response to several perioperative stimuli and so it might interfere in
      the effect of the anesthetic drugs on the brain. This study was designed to investigate the
      effect of esmolol on the consumption of propofol and sevoflurane in patients undergoing
      craniotomy.
    

Detailed description: 
      Patients undergoing elective craniotomy for aneurysm clipping or tumor dissection were
      randomly divided in two groups (four subgroups). Anesthesia was induced with propofol,
      fentanyl and a single dose of cis-atracurium, followed by continuous infusion of remifentanil
      and either propofol or sevoflurane. Patients in the esmolol group received 500 mcg/kg of
      esmolol bolus 10 min before induction of anesthesia, followed by additional 200 mcg/kg/min of
      esmolol. Monitoring of the depth of anesthesia was also performed using the Bispectral
      Index-BIS. It was also performed monitoring of the cardiac output in order to evaluate the
      effect of esmolol on cardiac output.

      The inspired concentration of sevoflurane and the infusion rate of propofol were adjusted in
      order to maintain a BIS value between 40-50.

      Intraoperative emergence was detected by the elevation of BIS value, HR or MAP.

      It was recorded intraoperative fluctuations of propofol and sevoflurane in both groups. Data
      were expressed as mean ± SD. Differences in categorical data were evaluated using the student
      t test.
    

Intervention name(s): Esmolol; Placebo; Propofol and sevoflurane
Intervention type(s): Drug; Drug; Drug
Intervention description(s): effect of esmolol on intraoperative fluctuations of propofol and sevoflurane. Propofol and sevoflurane intraoperative concentration will be expressed as mean ± SD. Differences in categorical data will be evaluated using the student t test.
Other intervention name(s): propofol; sevoflurane
Intervention MeSH terms: Propofol; Sevoflurane; Esmolol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: esmolol; anesthetics
The Effect of Postpartum Kangaroo Father Care on Paternal Attachment
Condition: Nursing Caries
Study type: Interventional

Summary: 
      Objective: This study was conducted in a randomized controlled manner to determine the effect
      of kangaroo care (KC) on paternal attachment (PA).
    

Detailed description: 
      Objective: This study was conducted in a randomized controlled manner to determine the effect
      of kangaroo care (KC) on paternal attachment (PA).

      Design: The data for the study were collected using the introductory information form (IIF)
      and the father-infant attachment scale (FIAS). T test, Mann Whitney U test and Kruskal Wallis
      test were used for statistical analysis.

      Participants and setting: A total of 90 fathers, including 45 in the intervention group and
      45 in the control group who met the inclusion criteria of the study were included randomly.

      Keywords: Kangaroo care; father; paternal attachment; Turkey.
    

Intervention name(s): kangaroo father care
Intervention type(s): Behavioral
Intervention description(s): The effect of postpartum kangaroo father care on paternal attachment
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Single (Participant)
Primary purpose: Health Services Research
Cortical Visual Impairment and Visual Attentiveness
Condition: Cerebral Palsy; Cortical Visual Impairment
MeSH terms: Cerebral Palsy; Vision Disorders; Vision, Low
Study type: Interventional

Summary: 
      This study will investigate the effect of enhanced visual and cross-modal environments upon
      the visual attentiveness of multiply handicapped children diagnosed with Cerebral Palsy (CP)
      and Cortical Visual Impairment (CVI).

      Research Hypothesis

        1. Adapted visual environments which present controlled auditory, tactile, proprioceptive
           or contrasting visual background stimulation will enhance the visual attentiveness to a
           given visual stimulus of children diagnosed with CP and CVI.

        2. Systematic, repetitive, visual stimulation over time, improves the visual attentiveness
           and/or visual-motor responses of CP-CVI children.

        3. The analysis of additional behavioral responses to visual stimuli is a critical
           component in evaluating the perceptual development of visual attention in CP-CVI
           children.

      Use of Noldus: The Observer, an advanced objective computerized observation program, will
      enable precise detection of the neurobehavioral responses of the participants. Both overt and
      covert responses will be observed, analyzed and correlated to identify the level of attention
      of each participant.
    


Intervention name(s): cross-modal sensory stimulation
Intervention type(s): Behavioral
Intervention description(s): comparison of participant response to unimodal visual stimulation and to bimodal sensory stimulation
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Biosimilar Erythropoietin in Anaemia Treatment (Maintenance Phase Study)
Condition: Renal Anemia
MeSH terms: Anemia
Study type: Interventional
Phase: Phase 3

Summary: 
      This study is aimed to comprehensively establish the bio-similarity/bioequivalence in EPIAO®
      and EPREX® in terms of 52-week comparisons in efficacy, safety and immunogenicity. The
      targeted population is anaemia patients with end-stage chronic renal disease who previously
      received epoetin treatment and on haemodialysis.
    

Detailed description: 
      This is a prospective, randomized, double blind, parallel group two arm study to establish
      the therapeutic equivalence, safety and tolerability of EPIAO® as compared to EPREX® in the
      treatment of CKD related anaemia in subjects who are on haemodialysis. A total of 264
      subjects will be randomized into two groups in a 1:1 ratio. Treatment arm A will receive
      EPIAO® 1-3 times a week, intravenously for period of 52 weeks and treatment arm B will
      receive EPREX, 1-3 times a week, intravenously for period of 52 weeks.
    

Intervention name(s): EPREX®; EPIAO®
Intervention type(s): Drug; Drug
Intervention description(s): Recombinant human erythropoietin falls under the pharmacological class of haematopoietic / anti anaemic agents. It has been developed for the treatment of anaemia in subjects with chronic kidney disease.
Erythropoietin, also known as EPO, is a glycoprotein hormone that controls erythropoiesis, or RBC production. It is a cytokine (protein signalling molecule) for erythrocyte precursors in the bone marrow. Human EPO has a molecular weight of 34,000.; Recombinant human erythropoietin falls under the pharmacological class of haematopoietic / anti anaemic agents. It has been developed for the treatment of anaemia in subjects with chronic kidney disease.
Erythropoietin, also known as EPO, is a glycoprotein hormone that controls erythropoiesis, or RBC production. It is a cytokine (protein signalling molecule) for erythrocyte precursors in the bone marrow. Human EPO has a molecular weight of 34,000.
Other intervention name(s): Recombinant human erythropoietin; Recombinant human erythropoietin
Intervention MeSH terms: Epoetin Alfa
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Renal anemia; Haemodialysis; Maintenance phase
Preservation of Pancreatic Beta Cell Function Through Insulin Pump Therapy
Condition: Diabetes Mellitus
Study type: Interventional

Summary: 
      Type I diabetes (T1DM) is the second most common chronic illness effecting children in the
      USA. Worldwide, Type I diabetes is increasing in incidence, and its underlying etiology
      remains elusive. Nevertheless, recent data supports the notion that early and intensive
      management of Type I diabetes can 1) decrease long-term complications of diabetes; and 2) may
      significantly improve beta cell function and insulin secretion over ensuing years. To this
      end, we propose using insulin pump therapy to preserve and/or enhance residual endogenous
      B-cell secretory capacity among patients with newly diagnosed Type 1 DM. Furthermore, we
      anticipate that early use of an insulin pump will improve glycemic control beyond that
      achieved with standard multiple daily injection (MDI) therapy, and will be well-tolerated by
      the patient. These data will provide important pilot information to explore the potential
      role of intensive insulin pump therapy in the treatment of children newly diagnosed with Type
      I diabetes. The specific aim of this study is to test the following hypothesis: Early use of
      insulin pump therapy is effective in preserving or enhancing residual endogenous pancreatic
      B-cell secretory capacity among patients with newly diagnosed T1DM: Moreover, early use of an
      insulin pump will improve glycemic control beyond that achieved with standard multiple
      injection therapy, and will be well-tolerated by the patient.
    


Intervention name(s): MDI (split-mix NPH insulin + regular insulin or Lantus + Novolog® [or Humalog®]); CSII (Animas Corporation insulin pump, model IR 1200)
Intervention type(s): Drug; Device
Intervention description(s): MDI = 3-4+ insulin injections/day, using NPH + regular insulin or Lantus + insulin lispro; 12 month treatment duration.; CSII (insulin pump), using Animas Corporation insulin pump, model IR 1200.
Other intervention name(s): Novolog® or Humalog®; Animas Corporation insulin pump, model IR 1200
Intervention MeSH terms: Insulin; Insulin, Globin Zinc; Insulin Lispro; Insulin Aspart; Insulin, Isophane; Isophane Insulin, Human; Isophane insulin, beef
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Insulin pump; Beta cell
Study of Artery Conditions of 'At-risk' Asian People Not on Lipid-lowering Drugs
Condition: Cardiovascular Disease
MeSH terms: Cardiovascular Diseases
Study type: Interventional

Summary: 
      The purpose of this study is to obtain the distribution of measurements of the intima media
      thickness of carotid arteries in people with high cardiovascular risk.
    


Intervention name(s): Measurement of the Carotid Intima Media thickness; Blood sample testing for hs-CRP
Intervention type(s): Procedure; Biological
Intervention description(s): one time, radiological procedure on both sides of the neck; one time, blood sample taking
Intervention model: Single Group Assignment
Primary purpose: Screening
Keywords: Cardiovascular disease; Carotid Intima Media Thickness
Examination of the Relationship Between Foot - Body Posture and Balance and Gait in Duchenne Muscular Dystrophy
Condition: Foot Posture; Balance; Gait Disorders, Neurologic; Body Posture
MeSH terms: Muscular Dystrophies; Muscular Dystrophy, Duchenne; Nervous System Diseases; Gait Disorders, Neurologic
Study type: Observational

Summary: 
      Foot and body postures of patients with DMD will be evaluated. Foot structure characteristics
      such as foot length, metatarsal width, calcaneal valgus angle will be calculated for the foot
      posture. Also, the Foot Posture Index (FPI-6) scale will be used. The body posture will be
      evaluated with the New York Posture Scale. Many gait characteristics such as step length,
      cadence, support surface of the patients will be determined with GaitRite instrumented
      walkway. Patients' balance assessment will be evaluated with Bertec Balance Advantage. The
      statistical analysis method will determine the relationship between foot and body posture and
      gait and balance.
    


Intervention name(s): observational evaluation
Intervention type(s): Other
Intervention description(s): Patients will be evaluated only observationally without intervention
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Study population include just patients with Duchenne Muscular Dystrophy
Reconstruction of Proper Digital Nerve Defects in the Thumb Using a Pedicled Nerve Graft
Condition: Nerve Injury
Study type: Interventional

Summary: 
      A proper digital nerve (PDN) defect in the thumb can produce partial or complete sensory loss
      which can result in functional disability. This article reports the treatment of the thumb
      PDN defect using a pedicled nerve graft harvested from the dorsal branch of the PDN. Fourteen
      patients with the thumb PDN defect underwent a new surgical procedure in which the pedicled
      nerve graft was used to bridge nerve defect. For comparison, the investigators also collected
      a consecutive series of 21 patients with thumb PDN defects treated using a nonvascularized
      sural nerve graft. This study was designed to evaluate the efficacy of pedicled nerve
      grafting for PDN defects in the thumb.
    

Detailed description: 
      At final follow-up, the investigators measured the sensibility of the thumb pulps and the
      donor sites using the Semmes-Weinstein monofilament test and static 2-point discrimination
      (2PD) test. The test points were at the centers of the radial and ulnar portions of the thumb
      pulp and the donor sites separately. Each area was tested 3 times with a Dellon-Mackinnon
      discriminator. Two out of 3 correct answers were considered proof of perception before
      proceeding to another lower value.
    

Intervention name(s): pedicled nerve graft
Intervention type(s): Procedure
Intervention description(s): A pedicled nerve graft harvested from the dorsal branch of the PDN can be used for reconstruction of such defects. The graft is based on the second dorsal metacarpal artery.
Other intervention name(s): Vascularized nerve graft
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: defect; dorsal branch of the proper digital nerve; proper digital nerve; second dorsal metacarpal artery; pedicled nerve graft.