WhatsApp Reminder on Bowel Preparation Level
Condition: Bowel Preparation; WhatsApp Messenger; Colonoscopy
Study type: Interventional

Summary: 
      It is estimated that there are about 1.4 million patients with colorectal cancer (CRC)
      worldwide, with a rising trend in CRC incidence in many Asian Pacific countries. In Hong
      Kong, colorectal cancer ranks first in cancer incidence and second in cancer mortality based
      on data from 2014.

      CRC is one of the most preventable cancers because its development in general follows an
      adenoma-carcinoma sequence. Adenomas are considered precursor lesions for CRC. Recent
      guidelines from USA, Europe and Asia Pacific region recommend CRC screening for average-risk
      asymptomatic individuals starting at age 50. Modalities such as guaiac-based fecal occult
      blood tests (gFOBT), fecal immunochemical tests (FIT), flexible sigmoidoscopy (FS), and
      colonoscopy are among the acceptable options for CRC screening.

      While early detection and removal of colorectal adenoma by screening colonoscopy with
      polypectomy reduce CRC incidence and mortality, interval cancers (cancers that develop after
      a colonoscopy and before the next scheduled colonoscopy) may still occur and were reported to
      account for up to 10.5% of CRC. a CRC has been associated with proximal colon location, small
      lesion, flat lesion, missed lesion, inadequate examination, incomplete resection of lesion,
      tumor biology, and low adenoma detection rate (ADR). High ADR (eg, ≥ 20%) has been associated
      with a reduced risk of interval CRC.

      Bowel preparation includes diet restriction and proper use of laxative before the
      colonoscopy, and this is one of the important factors to ensure a high quality colonoscopy.
      Suboptimal bowel preparation may lead to decreased ADR, cecal intubation rate, and
      surveillance interval and increased procedural time. Efforts to improve bowel cleansing
      quality through traditional communication routines, including face-to-face verbal education,
      written booklet or visual aids or telephone-based re-instruction have proven to be useful. A
      recent study using WeChat, a widely used social media mobile app in China, has also shown to
      be effectively improving bowel preparation level of a mixed population who received
      diagnostic (77%), screening (15.8%) and surveillance (7.2%) colonoscopy. However, the impact
      of social media mobile app on the bowel preparation level of screening colonoscopy is not yet
      known. Hence, this study will investigate the effectiveness of the most popular social media
      app worldwide, WhatsApp in bowel preparation level of screening colonoscopy.
    

Detailed description: 
      It is estimated that there are about 1.4 million patients with colorectal cancer (CRC)
      worldwide, with a rising trend in CRC incidence in many Asian Pacific countries. In Hong
      Kong, colorectal cancer ranks first in cancer incidence and second in cancer mortality based
      on data from 2014.

      CRC is one of the most preventable cancers because its development in general follows an
      adenoma-carcinoma sequence. Adenomas are considered precursor lesions for CRC. Recent
      guidelines from USA, Europe and Asia Pacific region recommend CRC screening for average-risk
      asymptomatic individuals starting at age 50. Modalities such as guaiac-based fecal occult
      blood tests (gFOBT), fecal immunochemical tests (FIT), flexible sigmoidoscopy (FS), and
      colonoscopy are among the acceptable options for CRC screening.

      While early detection and removal of colorectal adenoma by screening colonoscopy with
      polypectomy reduce CRC incidence and mortality, interval cancers (cancers that develop after
      a colonoscopy and before the next scheduled colonoscopy) may still occur and were reported to
      account for up to 10.5% of CRC. a CRC has been associated with proximal colon location, small
      lesion, flat lesion, missed lesion, inadequate examination, incomplete resection of lesion,
      tumor biology, and low adenoma detection rate (ADR). High ADR (eg, ≥ 20%) has been associated
      with a reduced risk of interval CRC.

      Bowel preparation includes diet restriction and proper use of laxative before the
      colonoscopy, and this is one of the important factors to ensure a high quality colonoscopy.
      Suboptimal bowel preparation may lead to decreased ADR, cecal intubation rate, and
      surveillance interval and increased procedural time. Efforts to improve bowel cleansing
      quality through traditional communication routines, including face-to-face verbal education,
      written booklet or visual aids or telephone-based re-instruction have proven to be useful. A
      recent study using WeChat, a widely used social media mobile app in China, has also shown to
      be effectively improving bowel preparation level of a mixed population who received
      diagnostic (77%), screening (15.8%) and surveillance (7.2%) colonoscopy. However, the impact
      of social media mobile app on the bowel preparation level of screening colonoscopy is not yet
      known. Hence, this study will investigate the effectiveness of the most popular social media
      app worldwide, WhatsApp in bowel preparation level of screening colonoscopy.

      Subjects already recruited by other studies in Institute of Digestive Disease and arranged
      for an out-patient screening colonoscopy will be identified and recruited.

      Demographic data including age, sex, smoking and alcohol habits, comorbidities, education
      level, family income, time of using WhatsApp of the eligible subjects will be collected.
      Subjects will then be randomized to either standard group or WhatsApp group. As a usual
      practice, all subjects will receive a verbal explanation of bowel preparation by a healthcare
      professional on the day of appointment making. A detailed written bowel preparation
      instruction will be also given to subjects.

      For subjects randomized to the WhatsApp reminder group, they will receive an additional
      WhatsApp reminder with same content of the written instruction and a video of explanation of
      bowel preparation by a nurse 4 days prior colonoscopy. Subjects are encouraged to ask any
      question regarding the bowel preparation via WhatsApp. All these enquiries will be replied by
      the principal investigator during office hours.

      The colonoscopy results, including, the bowel preparation level and the number and nature of
      lesion found (if any) will be collected afterwards. Two investigators reviewed all the
      colonoscopy videos independently to grade the quality of bowel preparation by Boston Bowel
      Preparation Scale.
    

Intervention name(s): WhatsApp reminder
Intervention type(s): Other
Intervention description(s): An additional WhatsApp reminder with same content of the written instruction and a video of explanation of bowel preparation by a nurse 4 days prior colonoscopy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Diagnostic