bioihbjkbjnl/mcl2 huggingface dataset:
Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment.
Condition: Stroke, Acute; Infarction, Middle Cerebral Artery
MeSH terms: Stroke; Infarction, Middle Cerebral Artery; Infarction
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The aim of the study is to determine the safety and efficacy on an autologous CD34+ subset
      bone marrow stem cell infusion into the middle cerebral artery in patients who have suffered
      acute middle cerebral artery stroke.
    

Detailed description: 
      The proposed trial will involve the recruitment of a total of 20 patients.

      The cells will be collected from ten subject recruited as cases, via bone marrow sampling.
      The aspirate will be centrifuged on a Ficoll density gradient to isolate mononuclear cells,
      which will be resuspended in heparinized isotonic saline for infusion into the area of the
      stroke intra-arterially using the middle cerebral artery.

      The investigators will monitor each case and control for a period of 6 months post-stem cell
      infusion. Initially, they will be subjected to a review after one month,three months and
      finally 6 months.

      Assessment of adverse events will be by physical examination and measurement of laboratory
      parameters. Assessment of efficacy will be by physical examination and the measurement of
      laboratory, CT and MRI parameters.
    

Intervention name(s): Infusion on autologous CD34+ stem cells into middle cerebral artery
Intervention type(s): Procedure
Intervention description(s): Intraarterial infusion of autologous bone marrow stem cells into middle cerebral artery of acute stroke patients
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
KU Alternate Meal Energy Level Study
Condition: Obesity; Weight Loss
MeSH terms: Weight Loss
Study type: Interventional

Summary: 
      Compare intermittent versus continuous calorie restriction to learn more about these eating
      plans and determine whether they are useful and effective to lose weight and keep it off.
    

Detailed description: 
      The purpose of this study is to provide evidence for the feasibility of an alternative weight
      control strategy by comparing two diets to see how intermittent calorie restriction compares
      to continuous or daily calorie restriction for weight loss in 35 adults with overweight or
      obesity. These diets will be incorporated into a comprehensive and intensive weight
      management program involving weekly health education meetings, regular diet and physical
      activity tracking, and feedback from a registered dietitian.

      Each intervention includes 3 months of weight loss and 3 months of weight maintenance.

      Group 1: Follow a low-calorie diet every day (1,200 - 1,500 calories daily)

      Group 2: Follow an intermittent very-low calorie diet (500-800 calories). Participants in
      this group will alternate between days of 500-800 calories and days of structured eating
      using healthy eating principles.
    

Intervention name(s): Portion-Controlled Meals; Low-Calorie Diet; Intermittent Very-Low Calorie Diet
Intervention type(s): Dietary Supplement; Behavioral; Behavioral
Intervention description(s): Increase dietary structure using portion-controlled meals (PCM); Restrict calorie intake daily; Severely restrict calorie intake intermittently
Other intervention name(s): Intermittent Fasting
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: weight management; obesity; very-low calorie diet; intermittent diet
Green Tea, High in Epigallocatechin Gallate (EGCG) and Postprandial Fat Oxidation
Condition: Obesity; Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      The body of evidence regarding the health benefits of green tea has grown considerably during
      the last decade and includes antioxidant properties, anti- cancer, anti-obesity and
      anti-diabetes effects. There has been evidence that green tea extract favorably affect body
      weight and body fat and has positive effects on blood glucose control

      Aim of this study is to investigate the short term effect (3-day)of TEAVIGO (high in the
      catechin EGCG) on postprandial fat oxidation during different phases of the postprandial
      period in overweight subjects. Secondly, in a subset of volunteers changes in lipolysis and
      glucose metabolism will be studied in skeletal muscle and adipose tissue.
    


Intervention name(s): Effect of the green tea extract TEAVIGO, high in EGCG, on postprandial fat oxidation
Intervention type(s): Dietary Supplement
Intervention description(s): green tea extract TEAVIGO, high in EGCG
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
The Steno 780G Study
Condition: Type 1 Diabetes
MeSH terms: Diabetes Mellitus, Type 1
Study type: Interventional

Summary: 
      Treatment with insulin pumps and sensor-based glucose monitoring has proven superior to other
      treatment methods in type 1 diabetes. Still, the majority of people treated with insulin
      pumps and glucose sensors still does not meet the recommended sensor-based glycaemic targets.
      Automated insulin delivery systems, also known as closed-loop systems, have shown to improve
      TIR, TAR, and TBR compared with insulin pump and CGM systems that cannot automatically dose
      insulin.

      The primary objective of the Steno 780G study is to test the effects of the MiniMed 780G
      system in persons with T1D treated with insulin pump and CGM/isCGM who are not meeting
      glycaemic targets.
    


Intervention name(s): Minimed 780G insulin pump
Intervention type(s): Device
Intervention description(s): This will be a 14-week, open-label, randomised, parallel-group, controlled trial comparing the efficacy of an AHCL system (MiniMed 780G, Medtronic Diabetes, Northridge, CA) with usual care (i.e., a person's usual insulin pump and CGM/isCGM system). After the 14-week trial period, the control group switches to treatment with the MiniMed 780G system. The intervention group continues with the MiniMed 780G system. Both groups are monitored for another 14 weeks.
Intervention MeSH terms: Insulin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
SuperPath Versus Posterior Approach for THA
Condition: Surgical Approach; Hip Arthropathy
MeSH terms: Joint Diseases
Study type: Interventional
Phase: Phase 4

Summary: 
      The SuperPATH approach is a minimally invasive approach for total hip arthroplasty. This
      project randomized patients to the SuperPath versus posterior approach. Outcomes examined
      included functional, VAS pain, narcotic utilization, perioperative outcomes, and radiographic
      component positions. Participants were followed for 2 years. The aim was to examine if the
      SuperPATH approach provided significant advantages over the posterior approach on functional
      testing or return to work for patients.
    

Detailed description: 
      Background: The Supercapsular Percutaneously-Assisted Total Hip (SuperPATH) approach is a
      minimally invasive approach for total hip arthroplasty. It has been reported to show earlier
      mobilization, better gait kinematics, and short hospital length of stay. Our primary
      objective was to compare functional tests of timed up and go and timed stair climb
      preoperatively, at discharge, 2 weeks, and 6 weeks postoperatively. Secondary objectives
      included the return to function in weeks, Oxford hip scores, visual analog scale, narcotic
      utilization, perioperative outcomes, and radiographic component positions.

      Methods: Forty-six patients were randomized into two groups on the surgery day: the SuperPATH
      group (25 patients) and the Posterior group (20 patients). Outcomes examined included
      functional, VAS pain, narcotic utilization, perioperative outcomes, and radiographic
      component positions.
    

Intervention name(s): Superpath Approach
Intervention type(s): Procedure
Intervention description(s): This is a minimally invasive surgical approach for THA.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: superpath approach versus posterior approach
Masking: None (Open Label)
Primary purpose: Treatment
Treatment for Osgood Schlatter Patients With a Physiotherapy Program
Condition: Osgood-Schlatter Disease
MeSH terms: Osteochondrosis
Study type: Interventional

Summary: 
      This study is to compare the effect of a physiotherapy program to usual care treatment in
      patients with Osgood Schlatter disease (OSD). Patients will be randomly assigned into two
      groups. Group 1 will receive the physiotherapy program with myofascial massage, while group 2
      (usual care group USC) will receive usual care treatment.
    


Intervention name(s): physiotherapy program; usual care treatment
Intervention type(s): Other; Other
Intervention description(s): physiotherapy program with Myofascial Release Massage, stretching, strengthening.
2 sessions per week (duration 30 minutes per session) for 8 weeks, supervised by a physiotherapist; complemented by a home training program.; stretching,strengthening; 2 sessions per week (duration 30 minutes per session) for 8 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: randomised controlled parallel groups
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: myofascial massage; stretching; home exercises; strengthening; KOOS-Child-Questionnaire
Diffusion MRI in Appendicitis
Condition: Acute Appendicitis
MeSH terms: Appendicitis; Acute Disease
Study type: Observational

Summary: 
      In this study, it was aimed to investigate the effect of diffusion-weighted magnetic
      resonance imaging on diagnosis and surgical decision in patients with suspected acute
      appendicitis. Investigators believe that Diffusion-weighted magnetic resonance imaging is a
      valuable method in the diagnosis of acute appendicitis and in making the decision of surgery.
    


Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Patients who were admitted to the Department of General Surgery and Emergency Medicine with
        right lower quadrant pain of the abdomen, between January 2015 and May 2019, and scanned by
        diffusion weighted magnetic resonance imaging
      
Keywords: Acute appendicitis; Diffusion weighted magnetic resonance imaging; Diagnostic accuracy
Analgecine for the Treatment of Neuropathic Pain
Condition: Neuropathic Pain
MeSH terms: Neuralgia
Study type: Interventional
Phase: Phase 3

Summary: 
      A randomized, open-label , positive drug controlled (Neurotropin,Japan organs Pharmaceutical
      Co., Ltd. ), multi-center study to evaluate Analgecine's efficacy and safety for the
      treatment of neuropathic pain.
    

Detailed description: 
      The study was designed to evaluate the efficacy and safety of Analgecine for the treatment of
      neuropathic pain for 2 weeks. It was a randomized, open-label , positive drug controlled,
      multi-center study phase III clinical trial. Patients were recruited with age between 18 and
      80 and visual analysis scale (VAS) between 3 and 8. After randomization, subjects were
      divided into 2 groups: 1) Treatment with Analgecine as experiment group; 2) Treatment with
      Neurotropin as positive control group. There are 3 measurement time points on day 0, 7, 14
      after treatment to score patients pain with VAS. The changes of the VAS score at day 14 were
      compared between groups.
    

Intervention name(s): Analgecine; Neurotropin
Intervention type(s): Biological; Biological
Intervention description(s): Extraction from rabbit skin extract through vaccinia virus inoculation inflammation as an antigen immune reaction.; a natural bio-product obtained from rabbit skin extract through vaccinia virus inoculation inflammation as an antigen immune reaction.
Intervention MeSH terms: Neurotropin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Endometrial Injury and Implantation Rates Before First ICSI Cycle
Condition: Invitro Fertilization
Study type: Interventional

Summary: 
      Midluteal single endometrial strip will be taken using a Novak curett under general
      anasthesia to avoid discomfort and cramping and to proceed to cervical dilatation in case of
      forbidden cervix, the step that will be beneficial to embryo transfer procedure.

      Controller ovarian hyperstimulation; will be done using the long luteal phase agonist
      protocol and the short protocol(as judged by patient,s age ovarian reserve judged by day 3
      FSH and antral follicular count and previous history of ovarian response).

      Ovarian response will be monitored by vaginal ultrasound and HCG will be given when when
      there is >=1 follicle >=18 mm. and >=3 follicles >=16 mm. Ultasound guided oocyte retrieval
      will be carried out 35 hours later. Embryo transfer will be performed on day 2 or day 3 after
      oocyt retrieval according to number and quality of embryos.

      Embryo transfer will be carried out under trans-abdominal ultrasound guidance pregnancy test
      will be done using qualitative blood HCG detection 2 weeks after the embryo transfer.
    


Intervention name(s): Endometrial scratch injury
Intervention type(s): Procedure
Intervention description(s): midluteal single endometrial strip will be taken using a Novak curett under general anasthesia to avoid discomfort and cramping and to proceed to cervical dilatation in case of forbidden cervix
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: ICSI; endometrial injury; implantation rate
Effects of Core Stabilization Training With and Without Pressure Biofeedback in Patients With Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      Mechanical low back pain is an impairment of musculoskeletal system. Lifetime prevalence of
      low back pain is 60-85%. Frequent micro-trauma to the structures of the spine, poor control
      and stabilization leads to LBP and eventually causes functional limitation. The objective of
      the study to find whether Core Stabilization Training with Pressure Biofeedback could reduce
      pain and improves functional activity in patients with mechanical low back pain. To study the
      effectiveness of Core Stabilization Training with Pressure Biofeedback in reducing pain and
      improving functional activity in subjects with mechanical low backpain between the age group
      of 25-40 years. To find out the effect of core stabilization training with pressure
      biofeedback in reducing pain and improving functional activity in subjects with mechanical
      low back pain between the age group of 25-40 years. The study will be conducted on 30
      subjects between the age group of 25-40 years with mechanical low back pain and according to
      the inclusion criteria were recruited in the study. NPRS at rest and activity, Modified ODI
      will assess PRE and POST treatment. P value: less than 0.05 using SPSS (Statistical package
      for social sciences) for NPRS(pain at rest and activity) and modified ODI i.e. core
      stabilization training with pressure biofeedback had statistical improvement in NPRS (Pain at
      rest and activity) and modified ODI score. Core stabilization training with pressure
      biofeedback is effective inreducing pain (at rest and activity) and functional disability in
      subjects between the age group of 25-40 years with mechanical low back pain
    


Intervention name(s): pressure biofeedback; core stabilization exercises
Intervention type(s): Other; Other
Intervention description(s): : Core stabilization training with pressure biofeedback unit; : Core stabilization training without pressure biofeedback unit
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Pain; Back; Core stabilization; Pressure biofeedback
Oxidative Stress in Women Treated With Atosiban for Impending Preterm Birth
Condition: Premature Birth
MeSH terms: Premature Birth
Study type: Interventional

Summary: 
      Oxidative stress is recognized as a important factor in the pathogenesis premature birth.
      Preterm birth is defined as delivery before 37 completed weeks of gestation and it is the
      leading cause of neonatal morbidity and mortality. The investigators conducted this analysis
      to investigate the safety of administration of Atosiban - a reversible, competitive
      antagonist of the oxytocin receptor in the treatment of preterm labor and its impact on the
      level of oxidative stress after 48 hours of tocolytic treatment.
    

Detailed description: 
      Atosiban (1-(3-mercaptopropanoic
      acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithine-oxytocin) is licensed for clinical
      use in women suffering from threatened premature birth and is widely used in clinical
      practice in Europe because of its low side effect profile. The impact of Atosiban on
      pregnancy outcomes in women has been investigated in recent years and the research has shown
      its ability to reduce intracytoplasmic calcium release and downregulate prostaglandin
      synthesis as oxytocin receptor antagonist. While a role of Atosiban in the modulation of
      myometrial contractility is well-described, its effect on many other functions is not so well
      known.

      The serum and plasma samples take for the measurement of total oxidant status (TOS), total
      antioxidant status (TAS), level of 3-nitrotyrosine (3-NT), and carbonyl and thiol groups will
      be stored at -70°C in aliquots for subsequent biochemical analysis and processed within two
      months.
    

Intervention name(s): Atosiban
Intervention type(s): Drug
Intervention description(s): The initial dose of Atosiban (Tractocile, Ferring Pharmaceuticals A/S, Copenhagen, Denmark) will be give as a single intravenous bolus dose (6.75 mg in 0.9 ml isotonic sodium chloride solution). This will be follow immediately by intravenous infusion of 300 μg/min of Atosiban in 5% glucose for 3 hours, and then 100 μg/min for up to 48 hours. Venous blood samples from a forearm vein will take before and after 48 hours of continuous administration tocolytic therapy with Atosiban.
Other intervention name(s): Tractocile
Intervention MeSH terms: Atosiban
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Efficacy and Safety of Early Vitamin AD Supplementation in Very Preterm Infants
Condition: Efficacy and Safety
Study type: Interventional

Summary: 
      Bronchopulmonary dysplasia (BPD) is the most prevalent longterm morbidity among surviving
      extremely preterm infants and has a multifactorial etiology. BPD is associated with later
      risk of reactive airways disease, such as asthma, post neonatal mortality and adverse
      neurodevelopmental outcomes.Retinopathy of prematurity (ROP) is a common retinal neovascular
      disorder and a major cause of vision impairment or blindness in preterm infants, even with
      aggressed current standard care.Accumulating epidemiologic evidence suggests that vitamin D
      (VD) deficiency or insufficiency is associated with respiratory disease and metabolic bone
      disease in premature children.Vitamin A (VA) plays an integral part in lung growth and
      differentiation. VA is an essential micronutrient for normal visual function.

      Our prospective double-blinded randomized controlled trial will include infants born at <32
      weeks' gestation and admitted to six tertiary NICUs in China. Infants in the intervention
      (vitamin AD drops) group will receive the daily dose VA at 1500 IU/day with VD 500 IU/day,
      added to their enteral feeds in drop form as soon as minimal feeding was introduced, and
      continued to 28 days or discharge. Infants in the control group will receive an equivalent
      volume of a placebo solution. Following informed consent, enrolled infants will be randomly
      allocated to the control or VAD group. The primary outcome is bronchopulmonary dysplasia
      (BPD) , ROP, or metabolic bone disease and the secondary outcomes are mortality; NEC ≥ stage
      2; ; late-onset sepsis; weight gain, change in weight, increase in length, increase in head
      circumference; time to full enteral feeds; and number and type of critical incident reports.
    


Intervention name(s): Vitamin AD; Control
Intervention type(s): Other; Other
Intervention description(s): In Vitamin AD group, the very preterm infants will receive the daily vitamin AD with vitamin A at 1500 IU/day and vitamin D at 500 IU/day in drop form added to their enteral feeds when minimal feeding is introduced, and continue to 28 days or discharge. In this group ,the patient also will receive standard intravenous multivitamin preparation (1 ml/kg/d,containing VA 230 IU/kg/d, VD 80 IU/kg/d) within daily on parenteral nutrition until fed 120ml/kg.; In this group ,the patient will only receive standard intravenous multivitamin preparation (1 ml/kg/d,containing VA 230 IU/kg/d, VD 80 IU/kg/d) within daily on parenteral nutrition until fed 120ml/kg.
Intervention MeSH terms: Vitamins
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Prevention
Effects of Pistachios on Cardiovascular Responses to Stress in Type 2 Diabetes
Condition: Cardiovascular Disease; Type 2 Diabetes
MeSH terms: Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      This study is investigating the effects of three different diets, including a diet with
      pistachios, on cardiovascular disease risk markers in people with type 2 diabetes.
    

Detailed description: 
      The study will last 12-16 weeks and requires 10-13 visits to the General Clinical Research
      Center on the University Park campus. All food and snacks will be provided for 10 weeks. At
      the end of each of three diet periods, participants will undergo a test of endothelial
      function, an oral glucose tolerance test, and a cardiovascular stress reactivity test.
    

Intervention name(s): Pistachio
Intervention type(s): Other
Intervention description(s): 3.0 oz (2 servings) of roasted and salted or unsalted pistachios
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Cardiovascular Disease; Type II Diabetes; Nutrition; Pistachios; Cardiovascular disease risk factors in adults with Type II diabetes
Effect of Massage on Hamstring Muscle Soreness
Condition: Musculoskeletal Disorders
MeSH terms: Musculoskeletal Diseases
Study type: Interventional

Summary: 
      Delayed onset muscular soreness peaks in 24-48 hours after unaccustomed strenuous physical
      exercise. Therapists often provide manual massage with the hands to acutely relief the
      soreness. Alternatives to manual hand massage can be useful for therapists. Here the
      investigators examine the acute effect of a "massage roller" on DOMS in the hamstring muscles
    


Intervention name(s): Massage
Intervention type(s): Other
Intervention description(s): The hamstring muscle will be massaged with a "massage roller" for ten minutes.
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention