Mother-caregivers of Children With Duchenne Muscular Dystrophy
Condition: Other Diseases or Conditions
MeSH terms: Muscular Dystrophies; Muscular Dystrophy, Duchenne; Disease
Study type: Interventional

Summary: 
      The incidence of Duchenne Muscular Dystrophy (DMD) is approximately 1 in 3.500 male newborns.
      During its progression there is loss of mobility, swallowing difficulties and a significant
      reduction in respiratory capacity. Due to the severity and consequences, is inevitable the
      need for a caregiver, that normally rely the mother.
    

Detailed description: 
      The Duchenne Muscular Dystrophy (DMD) is a neuromuscular disease characterized by genetic
      alteration, whose consequence is the progression of muscle degeneration. The mother-caregiver
      dedicates herself entirely to her son, putting aside the care of their physical and
      psychological health. The responsibility and workload to care for the child is high. Because
      of this extreme amount of work associated with other factors such as stress, this
      mothers-caregivers are more likely to develop hypertension, respiratory disease,
      susceptibility to infections, depression, anxiety, insomnia, impaired immune and
      cardiovascular problems. Moreover, they are more likely to develop sleep disorders, those who
      may cause a high health risk, since many sleep disorders are related to cardiovascular,
      respiratory, neurological and immune systems.
    

Intervention name(s): sleep parameters; Hormonal profile; Inflammatory profile; Cardiovascular profile; Metabolic profile
Intervention type(s): Biological; Biological; Biological; Biological; Biological
Intervention description(s): Since the mother-caregiver dedicates herself entirely to her son, we will performe overnight polysomnography to assess the sleep pattern.; To assess the health profile of caregivers-mothers are analyzed some markers that may indicate an impairment or damage to the health of each of the parameters.; To assess the health profile of caregivers-mothers are analyzed some markers that may indicate an impairment or damage to the health of each of the parameters; To assess the health profile of caregivers-mothers are analyzed some markers that may indicate an impairment or damage to the health of each of the parameters; To assess the health profile of caregivers-mothers are analyzed some markers that may indicate an impairment or damage to the health of each of the parameters
Other intervention name(s): Insulin; Cortisol; Luteinizing hormone (LH); Follicle-stimulating hormone (FSH); Total Testosterone; Estradiol; Progesterone; Vitamin B12; Adrenocorticotropic hormone (ACTH); C-reactive protein (PCR); Immunoglobulin A (IgA); Immunoglobulin G (IgG); Immunoglobulin M (IgM); Complement (C3); Complement (C4); Interleukin 6; Interleukin 10; Interleukin 1β; Interleukin 2; Interleukin 4; Interleukin 8; Interferon-gamma (IFN-γ); Endothelin; Prostaglandin E2; Intercellular Adhesion Molecule 1 (ICAM); Vascular cell adhesion protein 1 (VCAM); Tumor necrosis factor (TNFα); Adiponectin; Leptin; Cysteine; Lymphocytes subpopulations (T e B); Homocysteine; Myoglobin; Cardiac troponin I; Creatine kinase (CK); Creatine kinase MB (CKMB); Glucose; Total cholesterol and fractions; Triglycerides; Uric acid; Creatinine; Urea; Sodium; Potassium; Hemogram; Erythrocyte sedimentation rate; Natriuretic Peptide B
Intervention MeSH terms: Vitamin B 12; Interferons; Interferon-gamma; Interleukin-2; Interleukin-4; Dinoprostone; Hormones; Estradiol; Testosterone; Progesterone; Follicle Stimulating Hormone; Adrenocorticotropic Hormone; Melanocyte-Stimulating Hormones; Immunoglobulins; Immunoglobulins, Intravenous; Antibodies; Immunoglobulin G; Complement System Proteins; Immunoglobulin A; Immunoglobulin M; Uric Acid; beta-Endorphin
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Screening
Keywords: Duchenne;; mothers caregivers;; sleep;; hormonal profile;; cardiac profile;; biochemical profile;; inflammatory profile.