Exercise Capacity and Physical Activity Level in Prolactinoma Patients
Condition: Prolactinoma
MeSH terms: Prolactinoma
Study type: Observational

Summary: 
      Prolactinoma, one of the most common pituitary adenomas, is an adenoma that causes excessive
      prolactin (PRL) secretion. An increase in prolactin level can cause weakness, decrease in
      muscle mass and fatigue. It is not known in detail to what extent it affects quality of life,
      functional exercise capacity, cardiovascular disease risk factors, physical activity level,
      fatigue and sleep quality in prolactinoma patients. It is aimed to compare how much exercise
      capacity, physical activity level, sleep quality, perception of fatigue and quality of life
      of prolactinoma patients are affected compared to healthy individuals and to examine the
      factors associated with exercise capacity in prolactinoma patients.
    

Detailed description: 
      Prolactinoma is a pituitary adenoma caused by excessive prolactin secretion. More than 70% of
      patients are women. Many physiological conditions such as pregnancy, breastfeeding, breast
      stimulation, stress, exercise and sleep can also increase PRL levels. Prolactin can affect
      arterial stiffness and blood pressure and cause atherosclerosis in early menopause. In
      addition to these, it has negative effects on heart rhythm and heart failure. In addition to
      these clinical findings, the extent to which body weight gain and fatigue symptoms affect
      quality of life, functional exercise capacity, cardiovascular disease risk factors, physical
      activity level, fatigue and sleep quality in prolactinoma patients is not known in detail.
      There are very few studies on these subjects. Height, weight, waist circumference, hip
      circumference will be measured for all participants, waist-hip ratio and body mass index
      (BMI) will be calculated. The exercise capacity levels of the individuals who will
      participate in the study will be evaluated with the 6 Minute Walk Test (6MWT). Risk factors
      knowledge levels about cardiovascular diseases will be evaluated with Cardiovascular Diseases
      Risk Factors Knowledge Level (CARRIF-BD) Scale. Physical activity level will be evaluated
      with the Turkish version of the short form of the International Physical Activity
      Questionnaire (IPAQ). The Pittsburgh Sleep Quality Index (PUKI) was used to evaluate sleep
      quality. Fatigue assessment will be evaluated with the Multidimensional Fatigue Rating Scale.
      quality of life will be evaluated with the SF-36 short form. Measurement of knee extensor
      muscle strength will be made with a portable digital dynamometer (JTECH, Medical Commander
      Powertrack II, Midvale, USA). Peripheral muscle endurance assessment will be done by
      bilateral squat test.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Healthy group: Individuals between the ages of 18-55, female, not diagnosed with a
        pituitary adenoma, volunteered to participate in the study.

        Patient group: Individuals aged 18-55, female, diagnosed with prolactinoma, volunteered to
        participate in the study.
      
Keywords: Prolactinoma; exercise capacity; physical activity; quality of life