Effects of Intradialytic Exercise on Health-related Quality of Life
Condition: Exercise
Study type: Interventional

Summary: 
      This study aimed to evaluate the effects of intradialyic exercise on dialytic parameters,
      HRQL, and depression status in hemodialysis patients. A randomized controlled trial was
      conducted. Sixty-four participants were recruited using stratified random sampling and
      allocated with a 1:1 randomization ratio to either experimental group (EG, treated in odd
      weekdays, n = 32) or comparison group (CG, treated in even weekdays, n = 32). The EG received
      a 12-week intradialytic exercise, while the CG maintained usual lifestyles. Dialytic
      parameters, HRQL, and depression status were collected at baseline and at 12 weeks. The
      results indicated that there were no differences in changes of dialytic parameters from
      baseline between EG and CG. However, the EG had increased HRQL and reduced depression status
      at 12 weeks compared with the CG. A 12-week intradialytic exercise is safe, feasible and
      effective in improved HRQL and reduced depression status for hemodialysis patients.
    

Detailed description: 
      Exercise has been shown to be of fundamental importance in managing chronic diseases and
      improving health-related quality of life (HRQL) as well as psychological health. However,
      whether intradialyic exercise is safe and has positive impact on HRQL and depression status
      in hemodialysis patients requires further researches with diverse racial and cultural groups
      to clarify. This study aimed to evaluate the effects of intradialyic exercise on dialytic
      parameters, HRQL, and depression status in hemodialysis patients. A randomized controlled
      trial was conducted at a medical center in Northern Taiwan. Sixty-four participants from 112
      eligible hemodialysis patients were recruited using stratified random sampling and allocated
      with a 1:1 randomization ratio to either experimental group (EG, treated in odd weekdays, n =
      32) or comparison group (CG, treated in even weekdays, n = 32). The EG received a 12-week
      intradialytic exercise (supine lower-limb ergometer, 30 minutes/session, 3 sessions/week),
      while the CG maintained usual lifestyles. Dialytic parameters (serum chemistries, serum
      electrolytes, and estimated glomerular filtration rate), HRQL, and depression status were
      collected at baseline and at 12 weeks. The results indicated that there were no differences
      in changes of dialytic parameters from baseline between EG and CG. However, the EG had
      increased HRQL (ß = 22.6, p<.001) and reduced depression status (ß = -7.5, p = .02) at 12
      weeks compared with the CG. A 12-week intradialytic exercise is safe, feasible and effective
      in improved HRQL and reduced depression status for hemodialysis patients.
    

Intervention name(s): a 12-week intradialytic exercise
Intervention type(s): Behavioral
Intervention description(s): a 12-week intradialytic exercise (supine lower-limb ergometer, 30 minutes/session, 3 sessions/week)
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A randomized, controlled trial with a two parallel-group design
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: intradialytic exercise; hemodialysis; health-related quality of life