bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Ritalin on Postural Stability of Hyper Active Children
Condition: Attention Deficit Disorder With Hyperactivity
MeSH terms: Hyperkinesis; Attention Deficit Disorder with Hyperactivity
Study type: Interventional

Summary: 
      Experimental design overview The proposed project is a prospective experimental study design.
      Children (age <15) suffer from attention deficit hyperactivity disorder (ADHD) that their
      Parents willing to participate in the study will be tested with well-established measuring
      techniques of Balance control before and 1 hour after taking of Methylphenidate (Ritalin) in
      the movement and Rehabilitation Laboratory at BGU. An automated algorithm will be used to
      extract standardized stabilogram-diffusion parameters from each of the COP data sets
      collected during quiet standing. These parameters include diffusion coefficients, critical
      displacement, critical time and scaling exponents for both lateral and anterior-posterior
      sway directions (Collins & De Luca, 1993). For each of the conditions (before and 1 hour
      after the use of Ritalin) in three task conditions single task; dual task (concentrating and
      identifying specific music); and just Listening to a relaxing music. Participants will be
      required to stand on the platform 10 times for 30 s. For each trial, they will be instructed
      to sway as little as possible.
    


Intervention name(s): Ritalin
Intervention type(s): Drug
Intervention description(s): The effect of ritalin on postural stability of ADHD childrens will be measured using RCT study design
Intervention MeSH terms: Methylphenidate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: attention deficit hyperactivity disorder (ADHD); Dual tasking; Postural Control; Methylphenidate (Ritalin); The focus of the study is To explore the effects of Ritalin on postural control in ADHD Children, during single and dual task conditions.
Pharmacokinetic Properties of Two Dosages Nevirapine Extended Release (XR) Formulations Compared to VIRAMUNE® Tablet as Well as to Nevirapine XR Tablet in Healthy Male Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      Study to determine the pharmacokinetic properties of 200 mg (2 x 100 mg tablets once daily)
      and 300 mg (3 x 100 mg tablets once daily) Nevirapine extended release formulations and to
      estimate relative bioavailability of these formulations as compared to 200 mg VIRAMUNE®
      tablet as well as to 400 mg Nevirapine extended release tablet
    


Intervention name(s): Nevirapine XR low dose; Nevirapine XR medium dose; Nevirapine XR high dose; Nevirapine (VIRAMUNE®)
Intervention type(s): Drug; Drug; Drug; Drug
Intervention MeSH terms: Nevirapine
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Pilates Pelvic Floor Strengthening Program to Improve Urinary Incontinence
Condition: Stress Urinary Incontinence
MeSH terms: Urinary Incontinence; Enuresis; Urinary Incontinence, Stress
Study type: Interventional

Summary: 
      Does a twice weekly, 12-week Pilates pelvic floor strengthening program improve short- and
      long-term measures of stress urinary incontinence symptoms in women ages 45-70 years of age?
    


Intervention name(s): Pilates pelvic floor strengthening
Intervention type(s): Other
Intervention description(s): Pilates pelvic floor strengthening.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: pelvic floor; strengthening; Stress; urinary; incontinence
The Effect of Hypertension Medications on Renal Blood Flow Measurements in Healthy Males (MK-0000-127)
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will evaluate the effect of Aliskiren and Losartan on renal blood flow using PAH
      clearance, PC MRA and ASL MRI methodologies.
    


Intervention name(s): Aliskiren; Aliskiren; Comparator: Losartan; Comparator: Placebo to Aliskiren; Comparator: Placebo to Losartan
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): Single dose of four 150 mg tablets (600 mg total) Aliskiren in one of three study periods. There will be at least 10 days between each study period.; Single dose of one 150 mg tablet of Aliskiren in one of three study periods. There will be at least 10 days between each study period.; Single dose of one 100 mg tablet Losartan in one of three study periods. There will be at least 10 days between each study period.; Three or four tablets placebo to Aliskiren 150 mg in one of three study periods. There will be at least 10 days between each study period.; Single dose of placebo to Losartan 100 mg in one of three study periods. There will be at least 10 days between each study period.
Intervention MeSH terms: Losartan
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Application of Different Techniques of Elastic Bandage
Condition: Forearm Muscle Strain
Study type: Interventional

Summary: 
      This study will be featured as a randomized controlled. As the dependent variable, was
      considered isometric grip manual force. As independent variable, the presence or absence of
      forearm bandage in the fist flexor region of the volunteers.
    

Detailed description: 
      This study is directed to the population of students at the University of Mogi das Cruzes
      (UMC), and will take part of this study forty volunteers, twenty men and twenty women, aged
      from eighteen and thirty-eight years old. Will be selected and included volunteers who do not
      do physical professional activity with upper members, which have no symptom of pain skeletal
      muscle in the upper members, which have not undergone any type of surgery in the region of
      the forearm and hand of both members. Will be excluded the volunteers who have injuries,
      joint injuries, neuromuscular disorder or those who have knowledge of own vestibular or
      neurological changes. Will also be excluded from study volunteers who do not agree to
      participate after reading and understanding of informed consent in accordance with resolution
      466/12 of the National Ethics Committee and Research. The data acquisition interface will be
      acquired by an electromyography e a standard of strentgh will maintened in forty Newtons
      assured by an electronic dynamometer for tests of palmar prehension without and with
      bandages. The volunteers will not know what kind of intervention will pass. After each
      application before testing, their both forearms will be covered with a protection. The
      researcher and the volunteers will not know the tests order.
    

Intervention name(s): Without bandages; With placebo; With bandage; With tensioned bandage
Intervention type(s): Diagnostic Test; Diagnostic Test; Diagnostic Test; Diagnostic Test
Intervention description(s): All volunteers will be held the grasping force measurements without application of elastic adhesive bandage or micropore; All volunteers will be held the grasping force measurements with application of micropore (placebo) on his forearm in both upper members; All volunteers will be held the grasping force measurements with application of bandage without tension in the forearm in both upper members; All volunteers will be held the grasping force measurements with application of bandage with twenty five percent tensioned on the forearm in both upper members
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Diagnostic
Macrophage Migration Inhibitory Factor for Diagnosing Endometriosis and Its Severity
Condition: Endometriosis
MeSH terms: Endometriosis
Study type: Observational [Patient Registry]

Summary: 
      Endometriosis is a chronic disease affecting women of reproductive age. Macrophage migration
      inhibitory factor (MIF) is one of non-invasive blood biomarker that was detected in sera of
      endometriotic patients.The aim of this study was to evaluate the value of serum macrophage
      migration inhibitory factor in diagnosing endometriosis in women with infertility and chronic
      pelvic pain and correlate its level with the stage of the disease. Three hundred patient
      candidate for diagnostic laparoscopy were included in a case-control observational study
    

Detailed description: 
      observational case-control study conducted in Fayoum University hospital from March 2016 till
      September 2018. Three hundred women candidate for diagnostic laparoscopy for either
      infertility or gynecologic chronic pelvic pain were included. The study group included
      patients with diagnostic criteria of endometriosis. The control group included other causes
      of infertility or pelvic pain.
    

Intervention name(s): serum Eliza assay
Intervention type(s): Diagnostic Test
Intervention description(s): laparoscopy and biopsy of lesions in endometriotic patients and seum ELIZA assay of microphage migration inhibitory factor
Other intervention name(s): laparoscopy
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Both groups were comparable regarding the baseline characteristics. these included age,
        parity, Body mass index, symptoms, type of infertility and chronic pelvic pain
      
Keywords: Macrophage migration inhibitory factor; Endometriosis; Laparoscopy
Evaluation of the H-Coil Transcranial Magnetic Stimulation(TMS) Device- Augmentation for Drug Resistant Depression
Condition: Major Depression
MeSH terms: Depression; Depressive Disorder
Study type: Interventional
Phase: Phase 2

Summary: 
      There is a general consensus of efficacy of TMS in treatment of major depression,yet results
      are not satisfying.A new coil ("H"-coil, recently invented in Weizmann Institute of Science,
      Neurobiology Department, Rehovot, Israel) is supposed to be capable of stimulating deeper
      brain structures than conventional coils.TMS using this coil was named by its developers as
      "deep TMS" and will hence be refered to by this name.

      So far, deep TMS have studied in Israel with promising sucssess in patients with Major
      depression (An on-going study).A safety study with good results have been recently
      published.The aim of this study is to reinforce initial results in major depression using
      deep TMS.
    

Detailed description: 
      A group of 40 patients with major depression will be randomly assigned to deep TMS with H-1
      coil in frequency of 20 HZ or H-2 coil in frequency of 0.1 HZ with 120% of motor threshold to
      the prefrontal cortex . No change in anti-depressant medication one month prior to study is a
      prerequisite.Deep TMS will be administered for 4 weeks.During TMS exposure subjects will be
      exposed to a conversation in which they talk about their depression and their
      ruminations.Patients will be evaluated using Hamilton Depression Rating Scale
      (HAM-D24),Hamilton Anxiety Rating Scale (HAM-A),Clinical Global Impression -
      Improvement(CGI-I) ,Beck Depression Inventory (BDI),Visual Analog Scale (VAS).
    

Intervention name(s): TMS
Intervention type(s): Device
Intervention description(s): Transcranial Magnetic Stimulation (TMS) is a new tool in neuropsychiatry. This method is based on creating pre determined magnetic fields, which alternate rapidly. The magnetic fields are intended to cause electric induction in the brain cells and, as a consequence, generation of action potentials. The magnetic stimulation is delivered/ generated by a coil, positioned on the patient's scalp, inducing nerve stimulation within the brain. Therefore, when placed over the motor cortex, the magnetic stimulation creates Muscular Evoked potential, which can be measured by EMG.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Fat Perception in Humans (09-0873)
Condition: Obesity
MeSH terms: Obesity
Study type: Observational

Summary: 
      There are many substances naturally present in the mouth that may help us taste fat in food.
      Two of these substances (lipases and CD36) will be examined in this study.

      The presence of fat in food increases food tastiness, therefore people often over-eat
      high-fat foods and gain weight. The purpose of this study is to determine if blocking lipases
      and some genetic variations in the CD36 gene will make fatty food less tasty so that people
      eat less. Our hypothesis is that Orlistat and a particular gene will increase one's ability
      to detect fat.
    

Detailed description: 
      1. Determine the effect of lipolysis inhibition in oral cavity on orosensory detection of
           fat in humans.

           Hypothesis: Orally applied Orlistat will increase detection thresholds of TAGs but not
           FFA in humans.

           To test this hypothesis we will measure triolein (a TAG) and oleic acid (a FFA) taste
           detection thresholds with a three-alternative forced-choice (3-AFC) ascending
           concentration method under two conditions (Orlistat day vs. Control day). To control for
           olfactory input, subjects will be assessed wearing noseclips.

        2. Determine the effect of CD36 variants on fat taste perception in humans. Hypothesis:
           SNPs that associate with reduced CD36 expression will be associated with higher FFA and
           TAG detection thresholds

      To test this hypothesis we will measure triolein and oleic acid taste detection thresholds in
      subjects who carry of the common CD36 e-SNP rs1761667 (i.e. a SNP that significantly reduces
      CD36 level and has a minor allele frequency of 38-48%). We expect subjects who are at least
      heterozygous for the expression reducing allele to have higher triolein and oleic acid taste
      detection thresholds compared to non-carrier subjects.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        A total of 40 obese subjects will participate in this study. Subjects will be men and women
        and will include all races and ethnic groups. The two groups (carriers and non-will be
        matched as closely as possible in age, sex, body mass index (kg/m²) and race distributions.
      
Biospecimen description: 
      whole blood will be collected and frozen
    
Keywords: obesity; orlistat; taste perception
Effect of Diltiazem on Coronary Artery Ectasia
Condition: Coronary Artery Ectasia
MeSH terms: Coronary Aneurysm; Dilatation, Pathologic
Study type: Interventional

Summary: 
      Coronary artery ectasia (CAE) has been defined as localized or diffuse dilatation of
      epicardial coronary arteries more than 1.5 fold of adjacent normal segments. Isolated CAE
      constitutes minor portion of the total CAE cases, with an incidence of 0.1% to 0.79% in which
      coronary artery stenosis or severe valvular heart diseases are not present. CAE represents
      not only an anatomical variant but also a clinical constellation of coronary artery disease
      (CAD) like association with myocardial ischemia and acute coronary syndromes. Patients with
      CAE without significant coronary narrowing may still present with angina pectoris, positive
      stress tests, or acute coronary syndromes. Impaired epicardial and microvascular perfusion
      were demonstrated in ectatic coronary arteries.

      Myocardial blush grading (MBG) technique has been utilized in various conditions such as
      acute myocardial infarction, coronary artery ectasia, syndrome X and idiopathic dilated
      cardiomyopathy to evaluate myocardial perfusion.

      There is still no consensus for management of CAE. Previously improvement of coronary flow
      has been demonstrated by mibefradil in patients with slow coronary flow. A new trial is
      needed to explore the effect of calcium channel blockers (CCB) in isolated CAE. Diltiazem
      improves myocardial perfusion by blocking calcium channels in coronary arteries. This agent
      has been widely used in coronary catheter labs to prevent and treat no-reflow.

      The current study with prospective design was therefore set up to assess whether epicardial
      flow and tissue level perfusion would be improved by diltiazem in myocardial regions
      subtended by the ectatic coronary arteries among patients with isolated CAE.
    


Intervention name(s): intracoronary administration of diltiazem; intracoronary injection of 5 mL saline
Intervention type(s): Drug; Drug
Intervention MeSH terms: Diltiazem
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Diagnostic
Pharmacokinetic Study of Esomeprazole Magnesium in Patients 1 to 11 Years-Old With Endoscopically-Proven Gastroesophageal Reflux Disease (GERD)
Condition: Endoscopically-Proven GERD; Reflux
MeSH terms: Gastroesophageal Reflux
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine the area under the plasma concentration-time curve
      (AUC) of esomeprazole after single oral doses of 5 mg, 10 mg or 20 mg esomeprazole in
      pediatric patients 1 to 11 years-old inclusive with endoscopically-proven GERD.
    


Intervention name(s): esomeprazole magnesium
Intervention type(s): Drug
Intervention description(s): capsules, oral, qd, one day
Other intervention name(s): Nexium
Intervention MeSH terms: Esomeprazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Keywords: children; reflux; GERD; pediatric
Telemedicine as a Means to Achieving Good Diabetes Control Among Patients With Type 2 Diabetes
Condition: Type 2 Diabetes; Poor Glycemic Control; Medication Adherence
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      The aim of the study is to investigate the effect of telemedicine among the group of
      type-2-diabetics who, despite rehabilitation, remain poorly regulated. To describe the
      patients with regards to vulnerability and social resources and to determine wich groups
      benefit the most from telemedicine.
    

Detailed description: 
      Type-2-diabetes is a growing healthcare problem. Both because of the increasing amount of
      patients and because of the complications of diabetes.

      Non-pharmacological treatment is considered fundamental in the treatment of patients with
      type-2-diabetes.

      In the Community of Copenhagen, all patients diagnosed with diabetes receive rehabilitation.
      The rehabilitation consists of counseling with regards to nutrition, physical activity,
      smoking cessation and education about diabetes.

      Some patients however, remain poorly regulated despite rehabilitation as well as
      pharmacological treatment.

      A total number of 165 patients will be randomized to intervention group or standard care.
    

Intervention name(s): Telemedicine
Intervention type(s): Behavioral
Intervention description(s): Monthly video consultations with a nurse as add-on to standard treatment. The nurse has access to bloodsugar- bloodpressure and weight measurements uploaded by the participants to a tablet computer directly from the devices.
Patients on Insulin measure bloodsugar twice a day (fasting and before their evening meal). Patients not on Insulin measure bloodsugar once a week (fasting and before their evening meal). All participants measure bloodpressure and weight once a week. The intervention lasts 32 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Type 2 diabetes; Quality of life; Lifestyle intervention; Telemedicine; Videoconference
Efficacy of Combined Contraceptive Vaginal Ring(NuvaRing)in Women With Idiopathic Menorrhagia
Condition: Menorrhagia
MeSH terms: Menorrhagia
Study type: Interventional

Summary: 
      To compare the efficacy of a combined contraceptive vaginal ring (NuvaRing) and oral
      Norethisterone Acetate in treatment of Idiopathic heavy menstrual bleeding during fertile age
    


Intervention name(s): NuvaRing; Norethisterone Acetate tablets - 5mg
Intervention type(s): Drug; Drug
Intervention description(s): For the first cycle, women inserted the ring between days 1 and 5 of the menstrual cycle. Treatment continued for three cycles. Each cycle consisted of 3 weeks of ring use followed by a 1 week ring-free period.; Norethisterone Acetate tablets 5 mg three times daily from day 5 to 26 of the cycle over three cycles. Male condom used for contraception during treatment
Intervention MeSH terms: NuvaRing; Norethindrone; Norethindrone Acetate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Menorrhagia; Vaginal ring; Norethisterone Acetate
Post-surgical Chronic Pain After Retroperitoneal Laparoscopic Living Kidney Donor
Condition: Chronic Post Operative Pain; Kidney Transplant; Complications; Anesthesia Regional; Laparoscopy
MeSH terms: Chronic Pain; Pain, Postoperative
Study type: Observational

Summary: 
      This study aimed to determine the relationship between the quadratus lumborum and erector
      spinae plane block technique and the incidence and severity of chronic post-surgical pain in
      accordance with Brief Pain Inventory Score (BPI) in retroperitoneal laparoscopic living
      kidney donor surgery
    

Detailed description: 
      A minimum of 130 subjects will be recruited and divided into two groups (65 QL block, 65 ESP
      block). The researcher will use the Brief Pain Inventory (BPI) score to assess the incidence
      and severity of chronic pain of the living kidney donor who has undergone retroperitoneal
      laparoscopy with QL or ESP block technique
    

Intervention name(s): Quadratus lumborum (QL) block; Erector Spinae Plane (ESP) Block
Intervention type(s): Procedure; Procedure
Intervention description(s): bilateral anterior subcostal quadratus lumborum block; bilateral erector spinae plane block
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        The target population is all living kidney donor patients with retroperitoneal laparoscopy
        technique and performed QL or ESP block technique at RSUPN Dr. Cipto Mangunkusumo