bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Lean Pork, High Protein Breakfast on Satiety and Metabolic Health in Pre-diabetes
Condition: Pre-diabetes
MeSH terms: Diabetes Mellitus; Prediabetic State; Glucose Intolerance
Study type: Interventional

Summary: 
      The goal of this study is to assess the effects of consumption of a lean pork-containing,
      high-protein breakfast versus a refined carbohydrate-rich breakfast on satiety and
      cardiometabolic parameters in overweight or obese adults with pre-diabetes.
    

Detailed description: 
      This is a randomized, crossover trial that includes two screening visits, one baseline visit,
      and two test periods of 2 weeks each, each ending with a test visit, separated by a 2-week
      washout. Subjects consume each day a refined carbohydrate-rich breakfast containing 8/66/26%
      kcal from protein/carbohydrate/fat, respectively (Control Condition), or a high pork protein
      breakfast containing 35/39/26% kcal from protein/carbohydrate/fat, respectively (Active
      Condition). Study products for daily breakfast consumption will be dispensed to the subjects
      at the beginning of each test period. Subjects will complete 3-day diet records at baseline
      and the end of each test period, and a daily Appetite Visual Analog Scale (VAS) Diary to
      asses perceived hunger and fullness each evening before retiring throughout each test period.
      VAS assessments of hunger, fullness, desire to eat, prospective food consumption, focus and
      energy will also be assessed at the clinic visit at the end of each test period, pre- and
      post-breakfast consumption (multiple time points). Subjects will also complete a palatability
      questionnaire at the each of each test period. Blood samples will be collected at fasting at
      baseline and pre- and post-breakfast consumption (multiple sampling) at the end of each test
      period to evaluate glucose, insulin, and lipoprotein lipid concentrations.
    

Intervention name(s): Refined carbohydrate-rich breakfast; High pork protein breakfast
Intervention type(s): Other; Other
Intervention description(s): Refined carbohydrate-rich breakfast containing approximately 8/66/26% kcal from protein/carbohydrate/fat, respectively; High pork protein breakfast containing approximately 35/39/26% kcal from protein/carbohydrate/fat, respectively
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Pork; Refined carbohydrates; Satiety; Glucose; Insulin; Breakfast; Lipoprotein lipids
Comparing Site Specific Mouth Disinfection With Commercial Oral Mouth Rinse With Traditional Oral Maouth Disinfection
Condition: Oral Odor (Halitosis); The Study Want to Know if Site Specific Mouth Rinsing With Oral Mouth Disinfectants Can be Better Than Paonoral Mouth Rinsing
MeSH terms: Halitosis
Study type: Interventional
Phase: Early Phase 1

Summary: 
      Objectives: To determine whether site-specific mouth rinsing with oral disinfectants can
      improve oral odor beyond the traditional panoral mouth disinfection with mouth rinses by
      targeting specifically oral malodor implicate anaerobic bacteria.

      Methods: Twenty healthy fasting subjects volunteered for a blinded prospective, descriptive
      correlational crossover cross-section clinical trial conduct during the month of Ramadan in
      the lunar Hajri year 1434 AH (10 July 2013-8 August 2013) in Albaha province in Saudi Arabia
      involving the application of Listerine® Cool Mint® mouth rinse by either the traditional
      panoral rinsing method or a site-specific disinfection method targeting the subgingival and
      supragingival plaque and the posterior third of the tongue dorsum while avoiding the
      remaining locations within the oral cavity. The viable anaerobic and aerobic bacterial
      counts, volatile sulfur compounds (VSCs) levels, organoleptic assessment of oral odor and the
      tongue-coating index were compared at baseline, 1, 5 and 9 hours after the treatment.
    


Intervention name(s): traditional mouth rinsing and site-specific mouth rinsing (crossover)
Intervention type(s): Other
Intervention description(s): blinded prospective, descriptive correlational crossover cross-section clinical trial conduct during the month of Ramadan in the lunar Hajri year 1434 AH (10 July 2013-8 August 2013) in Albaha province in Saudi Arabia involving the application of Listerine® Cool Mint® mouth rinse by either the traditional panoral rinsing method or a site-specific disinfection method targeting the subgingival and supragingival plaque and the posterior third of the tongue dorsum while avoiding the remaining locations within the oral cavity
Intervention model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Supportive Care
Study of Microbiota in Longevity County, Yongfu
Condition: Aging; Healthy Aging
Study type: Observational

Summary: 
      This study is an observational study designed to adopt a cross-sectional study design. In the
      context of China's longevity town (East Asian population), Yongfu, Guangxi, the background of
      non-medical care and antibiotic use was explored, and the intestinal microecological balance
      increased with age and natural health. Longevity relationship. This study was completed using
      a household survey. Through routine clinical examinations and analysis of biochemical
      laboratory indicators, at the same time, a questionnaire for ADL(activities of daily living),
      cognitive function, and related elderly information was carried out on the elderly to
      comprehensively provide health information for each elderly. Based on the remaining stool
      samples and serum samples, the second-generation sequencing technology and other omics-based
      technologies were explored. No additional collection of human specimens and information is
      involved.

      In addition, this study also hopes to explore the transmission rules of age-related bacteria
      in long-lived families, and the relationship with health phenotypes such as blood sugar,
      blood lipids, and cognitive function. Potential impact. In summary, this study will provide
      data support for exploring the relationship between healthy longevity and intestinal
      microecological balance based on the characteristic population of the longevity hometown.
    


Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        The current study was based on the Longevity and Health of Aging Population in Guangxi
        China (LHAPGC) study conducted in Yongfu County (qualified as the longevity town by
        Geriatric Society of China) in 2016.The enrolled subjects do not rely on medical care and
        do not take antibiotics recently. They are representative of a natural healthy-aging
        population model .
      
Biospecimen description: 
      peripheral blood blood, 2 mL (serum) faeces, 200 mg
    
Keywords: Microbiota; multi-omics
CARES-HCV: Promoting Screening Uptake Among Diverse Baby Boomers
Condition: Hepatitis C Virus Infection; Colorectal Cancer
MeSH terms: Hepatitis C; Colorectal Neoplasms; Hepatitis
Study type: Observational

Summary: 
      The purpose of the study is to examine the efficacy of educational materials to promote
      hepatitis C virus (HCV) screening and colorectal cancer (CRC) screening uptake among adults
      born between 1945-1965.
    


Intervention name(s): CARES-HCV
Intervention type(s): Behavioral
Intervention description(s): CARES-HCV is an educational intervention to promote both hepatitis c screening and colorectal cancer screening among diverse baby boomers in the area.
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients born between 1945-1965 up to age 75 who have clinic visits at a partnering
        federally qualified health center.
      
Keywords: HCV Screening; CRC Screening
N-of-few Study of Pain Perception
Condition: Healthy
Study type: Interventional

Summary: 
      A behavioral study that will examine how pain perception is affected by different types of
      conditioning and by context, with a few participants and multiple sessions ("N-of-few"
      design).
    


Intervention name(s): Symbolic conditioning; Conditioning; Instructions; Counterfactual
Intervention type(s): Behavioral; Behavioral; Behavioral; Behavioral
Intervention description(s): Participants will learn associations between cues and thermal stimuli with varying temperatures (low vs. high) through symbolic conditioning (no actual heat stimuli, only pictures of thermometers); Participants will learn associations between cues and thermal stimuli with varying temperatures (low vs. high) from experience (with actual heat stimuli).; Participants will learn associations between cues and thermal stimuli with varying temperatures (low vs. high) from verbal instructions.; Thermal stimuli will be either the better outcome or the worse outcome out of two possible outcomes.
Intervention model: Single Group Assignment
Intervention model description: Within-participant design with behavioral manipulations.
Masking: None (Open Label)
Primary purpose: Basic Science
Statin Therapy to Improve Atherosclerosis in HIV Patients
Condition: Cardiovascular Disease; HIV; Atherosclerosis; Inflammation; Statins, HMG-CoA; HIV Infections
MeSH terms: Cardiovascular Diseases; Atherosclerosis; Inflammation
Study type: Interventional

Summary: 
      In HIV patients, statin therapy will attenuate plaque inflammation, thus, making plaques less
      vulnerable, will deter plaque progression, and improve endothelial function. In addition to
      known cholesterol-lowering and C-reactive protein lowering effects, immunomodulatory effects
      of statins will lead to a shift from pro-inflammatory monocyte and T cell subsets to less
      atherogenic subpopulations.
    


Intervention name(s): atorvastatin; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 20 mg PO QD for the first 3 months, followed by 40 mg PO QD for the final 9 months.; Placebo
Intervention MeSH terms: Atorvastatin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Cardiovascular Disease; HIV; Atherosclerosis; Inflammation; Statins; treatment experienced
Different Epidural Initiation Volumes
Condition: Pain, Postoperative
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      The aim of this study is to compare the effect of different epidural initiation volumes on
      postoperative pain scores, local anesthetic requirements, and motor block in patients who
      undergo patient controlled epidural analgesia for postoperative pain after cesarean section.
    

Detailed description: 
      90 minutes after combined epidural spinal catheter insertion, three different volumes (5 mL,
      10 mL, and 20 mL) are administered with a patient-controlled epidural analgesia (PCEA) device
      through the epidural catheter. For each group, 0.625% bupivacain + 2 μg/mL fentanyl, is
      administered.

      The visual analog scale, first analgesic demand time, the number of PCEA requirement per
      hour, morphine requirement, nausea-vomiting, itching, motor block, hypotension, and total
      consumed analgesic, and ephedrine amounts of the patients are recorded in the recovery room
      and at postoperative 2, 4, 6, 12 hours.
    

Intervention name(s): 5 mL epidural initiation volume (bupivacaine + fentanyl); 10 mL epidural initiation volume (bupivacaine + fentanyl); 20 mL epidural initiation volume (bupivacaine + fentanyl)
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 5 mL 0.625% bupivacaine + 2 μg/mL fentanyl solution is administered from epidural catheter; 10 mL 0.625% bupivacaine + 2 μg/mL fentanyl solution is administered from epidural catheter; 20 mL 0.625% bupivacaine + + 2 μg/mL fentanyl solution is administered from epidural catheter
Other intervention name(s): Bupivacaine(Marcaine 0.5%), Fentanyl(Talinat 0.5mg/10mL); Bupivacaine(Marcaine 0.5%), Fentanyl(Talinat 0.5mg/10mL); Bupivacaine(Marcaine 0.5%), Fentanyl(Talinat 0.5mg/10mL)
Intervention MeSH terms: Fentanyl; Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: cesarean section; combined spinal epidural anesthesia; patient controlled epidural analgesia; postoperative pain
Efficacy of Eye Movement Desensitization and Reprocessing (EMDR) in Dental Phobia
Condition: Dental Phobia
MeSH terms: Phobic Disorders
Study type: Interventional

Summary: 
      The purpose of this study is to find out whether Eye Movement Desensitization and
      Reprocessing (EMDR) is effective in the treatment of patients with dental phobia.
    

Detailed description: 
      Dental phobia represents a clinical condition that affects 5-15% of the community and is
      characterized by severe anxiety of dental treatment which leads to avoidance of treatment
      and, as a consequence, severe dental as well as psychosocial problems.

      Eye Movement Desensitization and Reprocessing (EMDR) has been developed for the treatment of
      patients with post traumatic stress disorder (PTSD). Its efficacy in PTSD patients has often
      been demonstrated in randomized controlled trials.

      Recently it has been demonstrated that dental phobia is often induced by traumatic events
      during dental treatment and goes along with symptoms of PTSD in numerous patients.

      A pilot study (de Jongh et al. 2002) gave hints on the efficacy of EMDR in four dental phobia
      patients with a history of traumatization during dental treatment.

      This randomized wait-list control study aims to evaluate the efficacy of EMDR in a larger
      sample of dental phobia patients.
    

Intervention name(s): Eye Movement Desensitization and Reprocessing (EMDR)
Intervention type(s): Behavioral
Intervention description(s): The intervention consists of three 90-minute sessions of individual psychotherapy. Sessions take place weekly according to a treatment manual.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: dental phobia; psychotherapy; eye movement desensitization and reprocessing - EMDR; efficacy; wait-list control
Use of Conjugated Linoleic Acid as a Nutraceutical for Weight Loss in Humans
Condition: Body Weight; Body Composition; Hyperlipidemia; Inflammation; Oxidative Stress
MeSH terms: Hyperlipidemias; Body Weight; Inflammation; Weight Loss
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of the study is to examine how a naturally occurring fat found in meats, such as
      beef and lamb and milk, called conjugated linoleic acid (CLA), will affect your body weight
      and body fat content, blood fat levels, as well as selected safety parameters. The CLA will
      be supplemented in an oil form and will be added to solid foods as provided by the metabolic
      kitchen at the Richardson Centre for Functional Foods and Nutraceuticals (RCFFN).
    

Detailed description: 
      In order to investigate the effectiveness of CLA on body weight and composition, as well as
      blood lipids, a double-blinded, 3-phase crossover trial will be conducted in moderately
      overweight (BMI=25-40 kg/m2), borderline hypercholesterolemic (LDL-C ≥ 2.5 mmol/L) men
      between the ages of 18-60 years. During three 8-week phases separated by 4-week washout
      periods, and under supervision to ensure compliance, 28 subjects will consume in random order
      (i) Control: 3.5 g/d of safflower oil, (ii) Clarinol G-80®: 3.5 g/d of 50:50 mixture of t10,
      c12 and c9, t11 CLA and (iii) c9, t11: 3.5 g/day of c9, t11 CLA. Body weight, fat mass and
      lean body mass will be measured at beginning and end of each phase by dual energy X-ray
      absorptiometry (DEXA). Baseline and endpoint blood samples will collected to determine blood
      lipid profile, and different safety parameters, including insulin sensitivity (HOMA-IR
      index), and concentrations of inflammatory (hs-CRP, TNF-α, IL-6) and oxidative (Oxidized-LDL)
      biomarkers. Effect of CLA consumption on fatty acid oxidation will also be measured.
    

Intervention name(s): Clarinol G-80 ® treatment; Safflower oil; G-c9, t11
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): dietary supplement of 3.5g/day 50-50 mixture of t10, c12 and c9, t11 CLA. In addition, the amount of mixed natural tocopherols is 5mg/g (0.05%).; 3.5 g/d of safflower oil; 3.5 g/day of c9, t11 CLA
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Conjugated linoleic acid; Body weight; Body composition; Blood lipid profile; Body inflammatory and oxidative status
Effects of Fermented Vegetables on Gut Microflora and Inflammation in Women
Condition: Inflammation; Women's Health; Gastrointestinal Microbiome
MeSH terms: Inflammation
Study type: Interventional

Summary: 
      This proposal will examine whether daily consumption of fermented vegetables for 6 weeks can
      impact the gut microflora and markers of inflammation of women between the ages of 18-70
      years.
    

Detailed description: 
      Interested participants will be invited to an orientation where study procedures will be
      explained in detail. Once the consent form is signed participants will schedule a visit to
      provide blood, urine and stool samples at the beginning of the intervention at which point
      they will be randomized into one of three groups: a fermented vegetable group (1/2 cup per
      day for 6 weeks), a non-fermented vegetable group (1/2 cup per day for 6 weeks) and a control
      group (usual diet). Both vegetable groups will receive weekly deliveries of the vegetables to
      be consumed. Following 6 weeks, participants will provide blood, urine and stool samples one
      more time. Participants will also fill out questionnaires related to dietary intake,
      demographics, physical activity, prescription medication use and gastrointestinal function.
      Compliance will be monitored weekly via a gastrointestinal function log where participants
      will be asked to enter whether they consumed or not the vegetable provided each day, as well
      as any side effects of consumption.
    

Intervention name(s): Fermented vegetable; Non-fermented vegetable
Intervention type(s): Other; Other
Intervention description(s): The intervention is to consume 1/2 cup fermented vegetables every day for 6 weeks; The intervention is to consume 1/2 cup of non-fermented vegetables every day for 6 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: This is a randomized parallel-arm trial
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Prevention
Hormonal Sensitivity in Patients With Noonan and LEOPARD Syndromes
Condition: Noonan Syndrome; LEOPARD Syndrome
MeSH terms: Noonan Syndrome; LEOPARD Syndrome; Hypersensitivity; Syndrome
Study type: Observational

Summary: 
      Noonan and LEOPARD syndromes share, with variable severity, different clinical traits,
      notably craniofacial manifestations, cardiopathies, short stature, and juvenile cancers.

      The main genetic cause of these syndromes is missense mutation of the gene encoding the
      ubiquitous tyrosine phosphatase Shp2, found in more than half the patients with NS and in 80%
      of LS cases. Shp2 plays pivotal roles in development, growth, and metabolism by regulating
      key signalling pathways (Ras/Mitogen activated protein kinase (MAPK), Phosphoinositide-3
      Kinases (PI3K)/Akt) in response to growth factors/hormones. Deregulation of these signalling
      pathways has been causally linked to NS and LS pathophysiology.

      This project aims at better understanding hormonal sensitivity abnormalities in patients with
      Noonan syndrome (NS) or LEOPARD syndrome (LS) caused by mutations of the tyrosine phosphatase
      Shp2.

      To reach this goal, the investigators will take advantage of different tissues (fibroblasts ±
      adipocytes) from patients with NS / LS compared to healthy controls.

      All patients will have a skin biopsy and only patients about to undergo surgery will have a
      adipose tissue biopsy.
    

Detailed description: 
      The activation of different signaling pathways (Ras/MAPK, PI3K/Akt) in response to growth
      factors/hormones (growth hormone, insulin) in fibroblasts and/or in adipocytes from patients
      with NS or LS will be compared to those of healthy subjects.

      These data will be correlated to clinical, hormonal, and biochemical characteristics of
      patients
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Data collected in patients with Noonan or LEOPARD syndromes will be compared to data of
        healthy subjects.
      
Biospecimen description: 
      Fibroblasts, adipocytes, serum
    
Keywords: Hormonal sensitivity; bone growth
Chemoradiotherapy of NSCLC Stage IIIB
Condition: NSCLC Stage IIIB; Concomitant Radiochemotherapy
MeSH terms: Carcinoma, Non-Small-Cell Lung
Study type: Interventional
Phase: Phase 2

Summary: 
      To evaluate the best timing of the concomitant chemoradiotherapy among patients with NSCLC
      stage III not resectable treated by concomitant chemo-radiotherapy, either preceded by a
      induction chemotherapy, or followed by a consolidation chemotherapy.
    

Detailed description: 
      Chemotherapy:

      C = Cisplatine : 80 mg/m² P = Paclitaxel : 200 mg/m² N = Vinorelbine : 15 mg/m²

      Radiotherapy:

      66 Gy with 33 fractions (2 Gy/fraction, 1 fraction/day, 6,5 weeks) High energy Photons X (>=
      9MV)
    

Intervention name(s): Paclitaxel, vinorelbine, cisplatin
Intervention type(s): Drug
Intervention MeSH terms: Paclitaxel; Vinorelbine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment