A Study of Characterizing Cognitive Decline and Functional Cardiac Senescence in Healthy Korean Volunteers
Condition: Aging; Mild Cognitive Impairment; Angina Pectoris
MeSH terms: Angina Pectoris; Cognitive Dysfunction
Study type: Observational

Summary: 
      -  Although aging process appears to be generally characterized, investigators have been
           paid much attention to the specific target molecules, which leads to discover the
           clinical markers of the senescence. The present study is to investigate the clinical and
           biological profile of cognitive decline and functional cardiac senescence in healthy
           middle aged and elderly Korean volunteers.

        -  This study was conducted as a cross-sectional, single-center, comparative clinical
           study.

        -  Each volunteer was given informed consent for checking cognition and cardiac function.
           Blood and urine samples were collected to analyze genome, proteome, and metabolome to
           assess cognition and cardiac function of its muscle enzymes.
    

Detailed description: 
      -  The protocol of this study was developed as the first assessment of the three to four
           series of clinical research on senescence.

        -  This design of the study is a non-interventional, single-center, single-visit design for
           investigating the cognitive decline and cardiac function including heart muscle enzyme
           activity, which have been considered one of the key points in aging process.

        -  Volunteers visit the study site during the screening period, informed consent for study
           participation and blood draw are given respectively, then, the eligibilities are met,
           participants visit the study site just once within two weeks.

        -  The participants undergo the following five procedures for 2-3 hours; out-patient visit,

             1. additional demographic interview including covariate factors (depression status,
                marital status

             2. vital sign check

             3. the questionnaire for cognitive function

             4. blood draw for genomic, proteomic, and metabolomic analyses (10 milli Liter), urine
                collection (20 milli Liter)

             5. electrocardiogram (ECG), then they are discharged.

        -  Their safety follow-up is monitored in a week (± 1 day) by a phone-call from the study
           associates.

        -  To evaluate cognitive function, several cognitive batteries were used, 3MSE
           (Modified-Mini Mental State Examination), ADAS-cog (Alzheimer's Disease Assessment
           Scale-cognitive subscale); for cognitive biomarkers, Apolipoprotein E, Type-3
           metabotropic glutamate receptors.

        -  To evaluate cardiac function including its enzyme activity: HRV (heart rate
           variability), CRP (c-reactive protein); Cardiac Troponin T.
    

Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Healthy middle aged (45-64 age) and elderly (over 65 age) person
      
Biospecimen description: 
      Samples for single nucleotide polymorphism, and for cardiac enzyme level detection
    
Keywords: Genotype-Phenotype Association; Aged; Middle Aged; Mild Cognitive Impairment; Heart Rate Control; Biomarkers