bioihbjkbjnl/mcl2 huggingface dataset:
The Effect of Allopurinol on Insulin Resistance and Blood Pressure
Condition: Metabolic Syndrome
MeSH terms: Metabolic Syndrome; Syndrome
Study type: Interventional
Phase: Phase 2

Summary: 
      Studies in animals have found that allopurinol can markedly improve fructose induced
      metabolic syndrome. In this study we test the hypothesis that allopurinol may lower BP,
      reduce triglycerides, and improve metabolic parameters in subjects placed on a high fructose
      diet.
    

Detailed description: 
      60 male subjects, age 40 to 65 years of age, will be placed on a 3500kcal (55% carbohydrates
      containing 200 g fructose) for 2 weeks. Half will receive allopurinol mg/day (randomized). At
      the end of 2 weeks we measure a variety of parameters including fasting glucose and insulin
      levels (with calculation of HOMA index), serum lipids (including triglycerides and LDL/HDL
      cholesterol), sitting blood pressure, serum uric acid, weight, and various other measurements
      (C reactive protein, adiponectin and leptin levels, and urate redox products). Primary
      endpoint is insulin resistance. Secondary endpoints are blood pressure, lipids, uric acid,
      weight.
    

Intervention name(s): Allopurinol; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Allopurinol 300 mg; Placebo given for 2 weeks
Intervention MeSH terms: Allopurinol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Uric acid; Fructose; Hypertension; Insulin; Glucose; HOMA
Comparison of Sciatic Nerve Gliding and Lower Extremity Dynamic Stretch on Hamstring Flexibility of Athletes
Condition: Sports Physical Therapy
Study type: Interventional

Summary: 
      In this research, the main purpose is to determine the comparison of acute effect of sciatic
      nerve gliding and lower extremity dynamic stretching exercises on hamstring flexibility and
      athletic performance. The participants will be begin with warm-up sessions for 3-5 minutes
      then baseline data (pre-test): hamstring flexibility will be measured. The order of pre-test
      will be randomized and same order will be used for post-test. This is a community service
      addition, added so that everyone in the society can get to know the effects of nerve gliding
      and lower extremity dynamic stretches on hamstring flexibility, will be cost effective, and
      will reduce their visits to the therapist.

      Randomized controlled trial with 1 month follow-up. The sample size is 40. subjects will be
      divided in two groups, 20 athletes will be given a session of sciatic nerve gliding while
      lower extremity stretch will be given to remaining 20 athletes. Study duration is of 6
      months.Sampling technique employed will be convenient with random assignment. Individuals of
      age group 18-40 years having male gender regularly exercise at least once a week for 30
      minutes. Tools used in the study are Universal inclinometer and Active knee extension test
      and SLR TEST. Data will be analyzed through IBM SPSS 23
    


Intervention name(s): NEURAL GLIDING; DYNAMIC STRETCH
Intervention type(s): Other; Other
Intervention description(s): with Sciatic nerve gliding which is done by applying force on the proximal point and releasing the force distally and then reversing the process. This process was achieved for 30 seconds, 6 times on each leg for a total time of 3 minutes (360 seconds).; The stretch force was applied on the ankle in downward direction which was held for 30 seconds and was repeated 5 times total of 2.5 minutes (150 seconds). Stretch was given on both legs one at a time. Treatment was given for 3 weeks with 2 sessions per week
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Efficacy and Safety of Olanzapine in Patients With Borderline Personality Disorder
Condition: Borderline Personality Disorder
MeSH terms: Personality Disorders; Borderline Personality Disorder
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of the protocol is to evaluate the efficacy and safety of olanzapine compared
      with placebo in patients with Borderline Personality Disorder (BPD).
    


Intervention name(s): Olanzapine
Intervention type(s): Drug
Intervention MeSH terms: Olanzapine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Evaluation of the Effectiveness, Safety, and Tolerability of Duac Akne Gel and Epiduo Gel in the Treatment of Facial Acne Vulgaris
Condition: Acne Vulgaris
MeSH terms: Acne Vulgaris
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to compare the effectiveness of two marketed products in
      subjects with facial acne vulgaris
    

Detailed description: 
      Multiple physiopathological factors have been associated with acne vulgaris. Drug
      combinations are frequently used to address these factors and to improve efficacy in the
      treatment of acne. The current study proposes to compare a fixed-dose (once-daily)
      combination gel product containing benzoyl peroxide (BPO)and clindamycin against a fixed-dose
      (once-daily) combination gel product containing BPO and adapalene for the treatment of facial
      acne vulgaris.
    

Intervention name(s): Epiduo Gel; Duac Gel
Intervention type(s): Drug; Drug
Intervention description(s): Epiduo Gel (combination of 0.1% adapalene and 2.5% benzoyl peroxide (BPO) in a gel preparation). Treatments administered once-daily in the evening for 12 weeks; Duac Akne Gel (combination of 1% clindamycin phosphate and 5% benzoyl peroxide (BPO) in a gel preparation). Treatments administered once-daily in the evening for 12 weeks
Other intervention name(s): Duac Akne Gel
Intervention MeSH terms: Adapalene, Benzoyl Peroxide Drug Combination
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Acne Vulgaris; Akne; Acne; Akne Vulgaris
Study of GC1008 in Patients With Idiopathic Pulmonary Fibrosis (IPF)
Condition: Idiopathic Pulmonary Fibrosis
MeSH terms: Pulmonary Fibrosis; Idiopathic Pulmonary Fibrosis; Fibrosis
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is designed to investigate whether GC1008, an antibody that neutralizes TGFb, is
      safe in treating patients with idiopathic pulmonary fibrosis. The highest dose without
      excessive side effects will be identified. Tests will determine how long GC1008 is in the
      body and how it is excreted.
    


Intervention name(s): GC1008; GC1008; GC1008; GC1008; GC1008
Intervention type(s): Biological; Biological; Biological; Biological; Biological
Intervention description(s): 0.3 mg/kg, IV on Day 0 and return to the clinic on 3,7, 10, 14, 21, 28, 42, 56, 84, 112, 140 post infusion for safety follow-up.; 1.0 mg/kg, IV on Day 0 and return to the clinic on 3,7, 10, 14, 21, 28, 42, 56, 84, 112, 140 post infusion for safety follow-up.; 2.0 mg/kg, IV on Day 0 and return to the clinic on 3,7, 10, 14, 21, 28, 42, 56, 84, 112, 140 post infusion for safety follow-up.; 4.0 mg/kg, IV on Day 0 and return to the clinic on 3,7, 10, 14, 21, 28, 42, 56, 84, 112, 140 post infusion for safety follow-up.; 8.0 mg/kg, IV on Day 0 and return to the clinic on 3,7, 10, 14, 21, 28, 42, 56, 84, 112, 140 post infusion for safety follow-up.
Intervention MeSH terms: Antibodies, Monoclonal
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: IPF; Idiopathic; Pulmonary; Fibrosis
Safety, Efficacy, and Tolerability of Vilazodone in Major Depressive Disorder
Condition: Major Depressive Disorder
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study was to further characterize the efficacy, safety, and tolerability
      of a single fixed dose level of vilazodone compared to placebo in patients with major
      depressive disorder.
    


Intervention name(s): Dose-matched placebo; Vilazodone
Intervention type(s): Drug; Drug
Intervention description(s): Dose-matched placebo was supplied as tablets.; Vilazodone was supplied as tablets.
Other intervention name(s): Viibryd
Intervention MeSH terms: Vilazodone Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Major depressive disorder; Depression
A Novel Way to Estimate Epidural Depth in Morbidly Obese Parturient
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional

Summary: 
      The purpose of this study is to determine the correlation between actual epidural needle
      depth (ND) and the use of ultrasound with an epidural depth equation (EQ-US) to estimate
      epidural depth (Est-D) in morbidly obese parturients. It is well documented that in women
      with a BMI greater than 40 kg/m2 successful epidural placement is more difficult. To the best
      of our knowledge the use of an epidural depth equation, which was developed in an earlier
      study using height and weight, with ultrasound visualization will improve identification of
      the epidural space.
    

Detailed description: 
      The investigators plan to enroll women who are morbidly obese (BMI > 40 kg/m2) and request
      epidural analgesia for labor. After written informed consent, 160 patients will have the use
      of the epidural depth equation with ultrasound (EQ-US) to estimate epidural depth (Est-D). US
      visualization of the epidural space will be completed by the principle investigator who has
      had extensive training in epidural US visualization. The EQ-US depth will be recorded. After
      US use, another provider who is listed as an investigator will place the epidural catheter
      without prior knowledge of the estimated epidural depth with the use of the equation and US.
      The actual needle depth to the epidural space (ND) will be recorded.

      Data collected from the patient's medical record will include demographic data (age, height,
      weight) gravidity, parity, and cervical dilation. Measured variables will include the
      estimated epidural depth (Est-D) as measured by the epidural depth equation with the use of
      ultrasound (EQ-US), and actual epidural needle depth (ND). The investigators believe that the
      use of ultrasound with the epidural depth equation (EQ-US) to estimate epidural depth (Est-D)
      in morbidly obese parturients will have a high correlation with actual epidural needle depth
      (ND).
    

Intervention name(s): Sonosite S-Nerve® US system (SonoSite, Bothell,WA)
Intervention type(s): Device
Intervention description(s): Ultrasound to measure depth to the epidural space in morbidly obese parturients
Other intervention name(s): Ultrasound machine; Sonosite
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Obesity; Ultrasound
Efficacy and Safety Study of Benralizumab Added to High-dose Inhaled Corticosteroid Plus LABA in Patients With Uncontrolled Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to determine whether Benralizumab reduces the number of asthma
      exacerbations in patients who remain uncontrolled on high doses of ICS-LABA.
    


Intervention name(s): Benralizumab; Placebo
Intervention type(s): Biological; Biological
Intervention description(s): Benralizumab subcutaneously on study week 0 until study week 44 inclusive.; Placebo subcutaneously on study week 0 until study week 44 inclusive.
Intervention MeSH terms: Benralizumab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Asthma,; Bronchial Diseases,; Respiratory Tract Diseases,; Lung Diseases,; Obstructive Lung Diseases
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of VAY736 in Rheumatoid Arthritis Patients
Condition: Rheumatoid Arthritis
MeSH terms: Arthritis; Arthritis, Rheumatoid
Study type: Interventional
Phase: Phase 1

Summary: 
      This study investigated the safety and tolerability of VAY736 administered as single
      ascending doses of intravenous infusion, subcutaneous injection and repeated subcutaneous
      injections in rheumatoid arthritis patients.
    

Detailed description: 
      This study had three sequential parts which investigated the safety and tolerability of
      VAY736 administered as single ascending doses of intravenous infusion (Part 1), single
      ascending doses of subcutaneous injection (Part 2), and repeated subcutaneous injections of
      fixed doses (Part 3), respectively, in rheumatoid arthritis patients. Part 1 was double
      blind, placebo controlled, with 11 cohorts. Part 2 was open-label study with 2 dosing
      cohorts. Part 3 was open-label study with 1 fixed-dose cohort.
    

Intervention name(s): VAY736; VAY736 placebo
Intervention type(s): Biological; Biological
Intervention description(s): VAY736 treatment; VAY736 placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Rheumatoid arthritis
A Study Comparing Trifarotene Cream 0.005% to AKLIEF® Cream in the Treatment of Acne Vulgaris
Condition: Acne Vulgaris
MeSH terms: Acne Vulgaris
Study type: Interventional
Phase: Phase 1

Summary: 
      To demonstrate therapeutic equivalence and safety of Trifarotene cream 0.005% (Taro
      Pharmaceuticals U.S.A., Inc.) and AKLIEF® cream in the treatment of acne vulgaris
    

Detailed description: 
      A multi-center, double-blind, randomized, placebo-controlled, parallel-group study, comparing
      Trifarotene Cream 0.005% (Taro Pharmaceuticals U.S.A., Inc.) to AKLIEF® Cream and both active
      treatments to a placebo control in the treatment of acne vulgaris
    

Intervention name(s): Trifarotene Cream 0.005%; Placebo; AKLIEF® Cream (Trifarotene 0.005%, Galderma Laboratories)
Intervention type(s): Drug; Drug; Drug
Intervention description(s): The study medication will be self-applied topically, on the affected areas of the face lightly, once daily at bedtime, avoiding contact with the mouth, eyes, and other mucous membranes for 84 consecutive days; The study medication will be self-applied topically, on the affected areas of the face lightly, once daily at bedtime, avoiding contact with the mouth, eyes, and other mucous membranes for 84 consecutive days; The study medication will be self-applied topically, on the affected areas of the face lightly, once daily at bedtime, avoiding contact with the mouth, eyes, and other mucous membranes for 84 consecutive days
Other intervention name(s): Test Product; Vehicle; Reference Product
Intervention MeSH terms: Trifarotene
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Oblique Versus Transverse Orientation Approach for Internal Jugular Venous Cannulation in Pediatrics
Condition: Heart; Surgery, Heart, Functional Disturbance as Result; Pediatric ALL
Study type: Interventional

Summary: 
      this study aimed to compare oblique versus transverse orientation approach in jugular venous
      cannulation in term of cannulation success in pediatric heart surgery patients
    

Detailed description: 
      Sixty patients randomised into two groups, 30 patients in experimental group (oblique
      orientation) and 30 patients in control group (transverse orientation). All cannulation took
      place in the operation room. Patients underwent general anesthesia and placed in supine
      position. Standard monitoring (electrocardiogram, non-invasive arterial pressure,
      pulseoxymetry) was carried out during the procedure for all patients. Before preparation of
      the skin, a pre-procedure ultrasound examination was performed to verify internal jugular
      vein patency, and its diameter was measured. Once the side had been chosen, the cannulation
      was performed following a sterile technique. All procedure were performed by Seldinger
      technique, with 22 Gauge IV catheter attached with 3 ml syringe as introducer needle. The
      vascular puncture was performed under ultrasound guidance, using a single-person technique.
      With transverse orientation, the transducer was placed transversally over the neck, and once
      the vein was visible in the middle of the ultrasound image, the needle was inserted in the
      plane perpendicular to the long axis of the transducer. With oblique orientation, the
      operator first obtained a transverse view of the vein and then rotated the transducer to 45
      degrees (midway) between transverse and longitudinal view.
    

Intervention name(s): internal jugular venous cannulation
Intervention type(s): Procedure
Intervention description(s): internal jugular venous cannulation
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: oblique orientation; transverse orientation; internal jugular venous cannulation; ultrasound guided; short axis; oblique axis
Doppler Sonography, MR Venography, Plethysmography for the Diagnosis of CCSVI
Condition: Chronic Cerebrospinal Venous Insufficiency
MeSH terms: Venous Insufficiency
Study type: Interventional

Summary: 
      This study is aimed at evaluation of diagnostic value of Doppler sonography, MR venography
      and air-plethysmography for the assessment of abnormalities in the internal jugular veins,
      with catheter venography as the reference test.
    


Intervention name(s): Doppler sonography of internal jugular veins; Magnetic resonance venography of internal jugular veins; Air-plethysmography of the neck; Catheter venography of internal jugular veins
Intervention type(s): Other; Other; Other; Other
Intervention description(s): Doppler sonography of internal jugular veins; Magnetic resonance venography of internal jugular veins; Air-plethysmography of the neck; Catheter venography of internal jugular veins
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Vascular malformations in the internal jugular veins
Price Changes and Nutrient Profiling Among Adult Grocery Shoppers
Condition: Nutrition; Food Purchases
Study type: Interventional

Summary: 
      The purpose of the research is to examine the association between price changes, nutrient
      profiling, and grocery food purchases among household grocery shoppers.
    

Detailed description: 
      Participants will be asked to select a week's worth of groceries for their household from a
      virtual online grocery store. Shoppers will be randomly assigned to one of four conditions
      (control, nutrient profiling, price change, nutrient profiling and price change).
    

Intervention name(s): Nutrient profiling; Price Changes
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Nutrient profiling system will be present during shopping session.; Price changes will be present during shopping session.
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Regular Physical Exercise in Duchenne Muscular Dystrophy
Condition: Muscular Dystrophy, Duchenne
MeSH terms: Muscular Dystrophies; Muscular Dystrophy, Duchenne
Study type: Observational

Summary: 
      This study examine whether an evidence-based individual user-preferred exercise program will
      increase the physical activity level in boys with Duchenne muscular Dystrophy (DMD).
    

Detailed description: 
      Regular physical activity is recommended in DMD. However, due to progression of muscle
      weakness and loss of function, a sedentary lifestyle is normal, and disuse of still
      functioning muscles leads to a secondary deterioration. Use of steroids have proven to
      decrease the rate of progression, and also leads to adverse advents like obesity and
      osteoporosis.

      Use of muscle strength training and aerobe exercise in DMD, may optimize muscle function,
      cardio-respiratory fitness and overall physical activity level, in addition to decrease
      possible adverse advents.

      In this study, children with DMD attending Haukeland University Hospital will be invited to
      participate (N≈14). The participant's physical activity level is registered during a four
      week baseline period and follow up. At start, 6 months and 12 months, a five day hospital
      stay will be conducted, both for testing and to prescribe an individual user preferred
      physical exercise program. The exercise program will be performed at home between the
      hospital visits. Benefits, safety and feasibility of regular physical exercise will be
      examined during follow-up and end of study. For comparison of the physical activity level and
      motor function, DMD children attending standards of care follow-up at others Norwegian
      regional pediatric rehabilitation clinics will be invited to participate in a control group.
    

Intervention name(s): Physical Exercise
Intervention type(s): Other
Intervention description(s): Physical exercise are prescribed to be performed three times per week for a year
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Boys with DMD from Hordaland county, attending the pediatric rehabilitation centre at
        Haukeland university hospital, will be recruited for intervention.

        For comparison, boys with DMD, attending other Norwegian pediatric rehabilitation centres
        will be invited as control group. Assessment of their physical activity level and
        self-reported physical activity level will be examined at start and after 12 months. In
        addition, functional abilities by use of North Star ambulatory assessment or EK2 scale will
        be assessed.
      
Biospecimen description: 
      Creatine Kinase (CK level)
    
Keywords: Physical Therapy Modalities; Exercise; Physical Activity; Exercise Program; Muscular Dystrophy, Duchenne