bioihbjkbjnl/mcl2 huggingface dataset:
An Investigation of the Gait Performance and Balance in Yoga Instructors
Condition: Gait; Yoga; Balance
Study type: Observational

Summary: 
      Yoga is a popular exercise and thought to be beneficial to many aspects such as mood,
      flexibility and balance, etc. Gait performance is a indicator of overall health and
      functional status. This study aims to investigate whether or not yoga instructors have a more
      symmetric gait pattern and better balance ability than healthy people without experience of
      performing Yoga. Inertial measurement units (IMUs) will be used to gather data related to
      gait symmetry and single leg stance balance. A comparison by four performance indexes related
      to gait symmetry and balance will be made to quantify the potential advantages of yoga
      practice.
    

Detailed description: 
      Yoga is a form of exercise with a focus on the structural alignment of the physical body. As
      Yoga movements involve a complex motion of core muscles and lower limb muscles, this exercise
      may be beneficial for gait stability. Gait performance is a sensitive indicator of overall
      health and functional status, and gait impairment can lead to a high risk of falling or
      diminished mobility. It was hypothesized that yoga instructors may have a more symmetric gait
      pattern and better balance ability than healthy non-yoga controls. Impact of yoga training on
      gait symmetry and single leg stance balance will be investigated. Twenty five yoga
      instructors and twenty five age/sex-matched healthy subjects will be recruited to conduct
      walking and static stability tests and these subjects' gait data and body movements will be
      measured during the experiments by attaching inertial measurement units (IMUs) to their lower
      limbs and trunks. Calculation of the subjects' asymmetry of swing phases during their gait
      cycles will be done to evaluate the gait performance. Afterwards, subjects will conduct four
      different one-leg stance tests. Two balance indexes will be defined and the recorded IMU data
      will be applied to evaluate the subjects' balance ability. Four performance indexes will then
      be defined to assess gait performance and single leg stance stability to quantify the
      potential advantages of yoga practice.
    

Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Yoga instructor: active and highly experienced Yoga instructor

        Healthy control: gender-matched healthy participants who had no experience with yoga
        training and participated in regular exercise 2 or 3 times a week
      
Keywords: Core muscle; Balance; Gait; Yoga; Symmetry; Inertial measurement units
Effects of a Pedometer-based Unsupervised Exercise Program Upon Lifestyle Physical Activity of Asthmatic Adults
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether a pedometer-based unsupervised exercise
      program is more effective than a general exercise recommendation to increase lifestyle
      physical activity in adult patients with asthma.
    

Detailed description: 
      The patients will be randomized in two groups: the intervention group will receive a
      standardized advice to physical activity practice plus pedometers and step goals to achieve
      over the next twelve weeks and the control group will receive the same standardized advice to
      physical activity practice and usual care.
    

Intervention name(s): Pedometer-based physical activity prescription
Intervention type(s): Behavioral
Intervention description(s): After baseline assessments, both groups will receive a educational session, regarding important aspects of asthma plus a unsupervised exercise prescription (walking, 5 times per week, for at least 30 minutes). Only the experimental group will receive a pedometer-based physical activity prescription, consisting of targets (steps per day) to be achieved. The initial target will be determined based on the average of steps per day assessed during the baseline assessments plus 1000 steps. The targets will be biweekly. Both groups will be contact once a week (by phone) and will be asked to return for asthma control assessments once a month.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Other
Keywords: Physical Activity; Pedometers; Quality of Life
Minimally Invasive Management During Endodontic Retreatment
Condition: Teeth, Endodontically-Treated
MeSH terms: Tooth, Nonvital
Study type: Interventional

Summary: 
      The study compares the prognosis of cases treated with "selective root retreatment" to the
      cases treated with traditional retreatment approach
    

Detailed description: 
      Post-treatment apical periodontitis is an inflammatory disorder of peri-radicular tissues
      caused by either persistent or secondary intra-radicular infection .Conventionally,
      nonsurgical retreatment has been believed to be an ''all or none'' treatment approach in
      which the endodontist has to remove all restorations from the tooth and to remove the
      obturation materials from all the canals in order to perform thorough disinfection of the
      entire root canal system. Nowadays, All operations in the medical field are aimed basically
      at the conservation of the human body. The alternative concept allows the endodontist to
      formulate clinical treatment decisions with respect to the presence of periapical pathosis
      related to individual roots rather than the tooth as a whole.

      The literature is lacking the clinical outcome studies dealing with the prognosis of cases
      treated with "selective root retreatment" concept so the aim of this study was to compare the
      prognosis of such cases in comparison to the traditional retreatment approach.
    

Intervention name(s): Endodontic retreatment
Intervention type(s): Procedure
Intervention description(s): Root canal retreatment in cases with secondary root canal infection
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Determining How the Nervous System Processes Pain in Adults With Fibromyalgia
Condition: Fibromyalgia; Rheumatoid Arthritis
MeSH terms: Fibromyalgia; Myofascial Pain Syndromes
Study type: Observational

Summary: 
      Fibromyalgia (FM) is a disabling chronic disorder characterized by widespread muscle pain,
      fatigue, and multiple tender points, specific places on the body that become painful with
      only slight pressure. Pain associated with FM cannot be explained medically, often leading to
      a delayed diagnosis and delayed treatment. The purpose of this study is to evaluate how the
      nervous system, specifically the brain, processes pain in women with FM.
    

Detailed description: 
      The cause of FM remains unknown, and more than half of all FM patients do not experience
      adequate pain relief from current treatment. Identifying the mechanisms of unexplained pain
      in people with FM is necessary to develop more beneficial treatments. One possible cause of
      FM may be associated with problems in how the body processes pain. People with FM appear to
      be hypersensitive to stimuli that normally are not painful. Specifically, the brain and
      spinal cord may not signal sensations correctly, resulting in abnormal pain sensations. This
      study will use functional magnetic resonance imaging (fMRI) to examine how pain is processed
      in the brain of adults with FM compared with adults with rheumatoid arthritis (RA), another
      chronic disease characterized by long-term pain with a known cause. This study will also
      determine the effect that anticipation and attention have on the processing of nonpainful
      stimuli in women with FM and RA. Both groups of people will also be compared to a control
      group of healthy people.

      Participants in this study will include only women. This study will include two study visits
      that will occur on separate days. Each study visit will last from 2 to 3 hours. During the
      first study visit, participants will complete questionnaires. They will then rate heat
      stimuli applied to their hand and perform mental tasks while in a mock MRI machine. The
      mental tasks will consist of naming the color of words. Some participants will receive
      nonpainful heat stimuli; others will receive both painful and nonpainful heat stimuli. During
      the second study visit, participants will undergo the exact same procedures while in an
      actual MRI machine. There will be no follow-up visits for this study.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Community and primary care clinic samples.
      
Keywords: Pain; Nociception
Volumetric Bone Mineral Density and it's Relationship With Osteoporotic Fractures in Parkinson's Disease
Condition: Idiopathic Parkinson's Disease
MeSH terms: Parkinson Disease; Osteoporotic Fractures
Study type: Interventional

Summary: 
      Idiopathic Parkinson's disease (IPD) is the second most frequent neurodegenerative disease.
      Its association with osteroporosis and fragility fracture is now clearly demonstrated, but
      the determinants of this osteoporosis are yet to be explained. Our aim was to study factors
      associated with volumetric bone mineral density (vBMD) and bone microstructure at the tibia
      and radius in IPD.
    


Intervention name(s): High resolution peripheral scanner (HRpQCT).
Intervention type(s): Other
Intervention description(s): radius and tibia osteodensitometry measurement
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Osteoporosis; Parkinson; HR-pQCT; bone microstructure; fracture risk
Educational Program for Knee Osteoarthritis
Condition: Knee Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional

Summary: 
      Sixty patients with a diagnosis of knee osteoarthritis, aged between 40 and 80 years, of both
      genders were included. The patients were divided into: experimental group that carried out an
      educational program - 5 consecutive sessions held once a week, with a duration of 60 minutes
      each class and at the end of the last class, a booklet was delivered for each patient with
      all the contents of the classes and the Transcutaneous Nerve Electro-Stimulation device -
      being performed twice weekly, for 5 weeks for 40 minutes each session; and control group who
      only underwent treatment with the Transcutaneous Nerve Electro-Stimulation in the same
      parameters as experimental group. The evaluations were performed at the beginning of the
      treatment, 4 and 12 weeks after the beginning of the treatment using a numerical pain scale;
      WOMAC; IDATE and SF-36 questionnaires; and 6-minute walk test.
    


Intervention name(s): Educational Program; Transcutaneous Nerve Electro-Stimulation
Intervention type(s): Other; Device
Intervention description(s): Educational program consist in 5 consecutive sessions held once a week, with a duration of 60 minutes each class and at the end of the last class, a booklet was delivered for each patient with all the contents of the classes. This group also received Transcutaneous Nerve Electro-Stimulation twice weekly, for 5 weeks for 40 minutes each session; Transcutaneous Nerve Electro-Stimulation performed twice weekly, for 5 weeks for 40 minutes each session
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Education; Pain; Function; Quality of life
Study to Assess the Food Effect of K-877 in Healthy Adult Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      Study is to assess the effects of food on the Pharmacokinetics(PK) of single-dose
      administration of K-877 in healthy adult volunteers.
    


Intervention name(s): K-877
Intervention type(s): Drug
Intervention description(s): K-877 Tablet
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Comparison of Different Materials Contribution to Implants Stability
Condition: Dental Implant Failure Nos
Study type: Interventional

Summary: 
      The investigators will use two types of material(PRF-Xenograft) in the buccal gap after
      immediate dental implant placement. The study design has three groups PRF, graft, and control
      group. The patients will randomly be assigned to groups by envelop method. The resonance
      frequency analysis device(Osstell) will be used to measure primary and secondary
      stabilization. Then the investigators will evaluate each materials' contribution to
      stability.

      Pre-op and 9th month Post-op CBCTs will evaluate about bone loss in mesial-distal and
      horizontal dimensions.
    


Intervention name(s): platelet-rich fibrin placement; xenogenic graft placement; no extra material; tooth extraction; immediate implant placement; collagen membran placement; raising flap
Intervention type(s): Other; Other; Other; Procedure; Procedure; Other; Procedure
Intervention description(s): filling the buccal gap with platelet-rich fibrin after immediate dental implant placement; filling the buccal gap with xenogenic graft after immediate dental implant placement; filling the buccal gap with no material after immediate dental implant placement; extraction of tooth which is unrestorable; putting dental implant into a socket which has been prepared with compatible drills; placing collagen membran on extraction socket after dental implant placement to cover all; raising the buccal flap with two vertical incision to cover extraction socket for primary closure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: immediate implant placement
Preventing Postpartum Depression With Intranasal Oxytocin
Condition: Depression, Postpartum; Anxiety
MeSH terms: Depression, Postpartum; Depression; Depressive Disorder
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to test a new treatment for preventing childbirth-related mental
      illness in postpartum mothers. The treatment is aimed at enhancing maternal bonding, reducing
      postpartum depression (PPD) and anxiety in mothers at risk, and promoting child development.
      To this end, the investigators will test the clinical utility of intranasal (IN) oxytocin
      (OXT) administered to mothers during the first postpartum days.
    

Detailed description: 
      Postpartum depression (PPD) is a debilitating disorder which imposes a threat to mother and
      infant health. An estimated 600,000 American women suffer from PPD annually, making it one of
      the most frequent complications of pregnancy. Available secondary preventive interventions
      are often ineffective, which calls for identifying novel means for prevention. Impaired
      mother-infant bonding is a hallmark of PPD. Depressed mothers may have difficulties
      developing maternal feelings and providing sensitive care. In turn, impaired bonding may
      worsen mother's depression. Conventional pharmacotherapy does not help with bonding
      impairment.

      This study will attempt to fill in the current gap in effective preventive interventions for
      pregnant mothers at risk. Evidence in postpartum mothers indicates that high peripartum OXT
      levels are associated with enhanced maternal behavior and low levels with depression. Data
      also indicates that in depressed mothers, OXT levels may decrease during the first days
      following childbirth rather than increase as is the norm. Therefore, the investigators will
      test the therapeutic effects of OXT in women at risk for PPD. It is hypothesized that
      administration of IN-OXT (total daily dose 48 IU) over the course of four days from as early
      as day one postpartum in comparison to placebo will 1) enhance mother-infant bonding, 2)
      reduce depressive and anxiety symptoms at 5 days postpartum, and 3) facilitate child
      development.
    

Intervention name(s): Oxytocin; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Study participants will be randomized to a placebo or drug group.; Study participants will be randomized to a placebo or drug group.
Other intervention name(s): Syntocinon; Salt solution
Intervention MeSH terms: Oxytocin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: oxytocin, bonding; child development
Clinical Investigation of the LCS® Complete Posterior Stabilized Mobile-bearing Total Knee System
Condition: Osteoarthritis; Rheumatoid Arthritis; Post-traumatic Arthritis; Juvenile Arthritis
MeSH terms: Arthritis; Osteoarthritis; Arthritis, Juvenile
Study type: Interventional

Summary: 
      Prospective, multi-center clinical study to evaluate the clinical outcomes of the posterior
      stabilized design of the LCS® Complete Mobile-bearing Total Knee System
    

Detailed description: 
      Prospective, multi-center study to evaluate the clinical outcome of posterior stabilized
      design of LCS® Complete Mobile-Bearing Total Knee System. No comparison group. 12 month
      enrollment, 12 month post-operative evaluation. Follow-up intervals: Pre-op, 3 month, 6
      month, and 12 month.
    

Intervention name(s): Total knee arthroplasty
Intervention type(s): Device
Intervention description(s): Total knee arthroplasty using a posterior stabilized implant
Other intervention name(s): LCS® Complete Posterior Stabilized Mobile-bearing Knee
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Total knee replacement; Total knee arthroplasty; Osteoarthritis; Rheumatoid or other inflammatory arthritis; Post-traumatic or juvenile arthritis
Effect of a Secure Message Reminder on Hypertension Follow-up at an Integrated Health Care System
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      This study will assess whether adding a secure message reminder to routine care improves the
      percentage of patients who complete a follow-up appointment with a new, documented blood
      pressure reading.
    

Detailed description: 
      Hypertension is one of the leading risk factors for cardiovascular disease. Optimizing blood
      pressure management can help prevent adverse cardiovascular outcomes. The National Committee
      for Quality Assurance (NCQA) defines blood pressure control as less than 140/90 mmHg. Per
      this definition, less than half of Americans with hypertension are considered controlled.
      Literature has been published describing several ways of improving blood pressure management,
      but results have been variable.
    

Intervention name(s): Secure message reminder
Intervention type(s): Other
Intervention description(s): Single secure message reminder asking subjects to schedule an appointment with their provider or make a nurse visit to follow-up on their blood pressure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: hypertension
Imatinib in Systemic Sclerosis
Condition: Scleroderma, Systemic
MeSH terms: Scleroderma, Systemic; Scleroderma, Diffuse
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and
      internal organs and widespread vasculopathy. Patients with SSc are classified according to
      the extent of cutaneous sclerosis: patients with limited SSc have skin thickening of the
      face, neck, and distal extremities, while those with diffuse SSc have involvement of the
      trunk, abdomen, and proximal extremities as well. The disease course varies depending on the
      subtype of SSc. However, common features that result in significant morbidity and mortality,
      in addition to cutaneous fibrosis, include Raynaud's phenomenon and digital ulcerations,
      interstitial lung disease (ILD), and pulmonary arterial hypertension (PAH). Current
      therapeutic options for patients with SSc and these clinical manifestations have shown
      limited efficacy.

      Imatinib antagonizes specific tyrosine kinases that mediate fibrotic pathways involved in the
      pathogenesis of SSc, including c-Abl, a downstream mediator of transforming growth factor
      (TGF)-beta, and platelet derived growth factor (PDGF) receptors. The efficacy of imatinib has
      also been reported in the treatment of patients with refractory idiopathic PAH through its
      effects on vascular remodeling. Based on the mechanism of action and preliminary patient
      data, we hypothesize that imatinib may be effective in the treatment of the fibrotic and
      vasculopathic features of patients with SSc. This is an open label pilot study to evaluate
      the safety and efficacy of imatinib in patients with progressive SSc refractory to other
      treatment(s). Validated measures of skin thickness and disease activity will be determined
      over 6-months of therapy and compared with baseline measures.
    


Intervention name(s): Imatinib mesylate
Intervention type(s): Drug
Intervention description(s): 100 mg orally daily increased by 100 mg/day every 2 weeks to maximum of 400 mg daily as tolerated. Treatment for 6 months total.
Intervention MeSH terms: Imatinib Mesylate
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment