bioihbjkbjnl/mcl2 huggingface dataset:
Effectiveness of Truclear on Patient Quality of Life
Condition: Heavy Menstrual Bleeding
MeSH terms: Menorrhagia; Hemorrhage
Study type: Interventional

Summary: 
      This study aims to evaluate the quality of life in patients treated for submucosal leiomyomas
      using the Truclear hysteroscopic morcellator compared to women managed medically. Study
      population includes women age 18 and older with symptomatic submucosal myomas. Patients will
      be asked to complete the Uterine Myoma Symptom and Health-related Quality of Life
      Questionnaire (UFS-QOL) at enrollment and at 1, 3, and 6 months after treatment.
    

Detailed description: 
      Submucosal myomas are a common cause of pelvic complaints and abnormal uterine bleeding (AUB)
      and there are many available modalities for treatment. Hysteroscopic myomectomy is a
      minimally invasive approach for removal of submucosal leiomyomas. Alternatively, medical
      management can be attempted. This study aims to evaluate the quality of life in patients
      treated for submucosal leiomyomas using the Truclear hysteroscopic morcellator compared to
      women managed medically. Study population includes women age 18 and older with symptomatic
      submucosal myomas. Patients will be asked to complete the Uterine Myoma Symptom and
      Health-related Quality of Life Questionnaire (UFS-QOL) at enrollment and at 1, 3, and 6
      months after treatment.
    

Intervention name(s): Hysteroscopic myomectomy with Truclear; Medical therapy
Intervention type(s): Procedure; Drug
Intervention description(s): Hysteroscopic myomectomy with Truclear done on patients with abnormal uterine bleeding and submucosal fibroid(s).; Medical therapy for patients with abnormal uterine bleeding/ heavy menses and submucosal fibroids.
Other intervention name(s): Truclear; oral contraceptive pills, Mirena intrauterine device
Intervention MeSH terms: Contraceptive Agents; Contraceptives, Oral; Contraceptives, Oral, Combined
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: submucosal fibroids; heavy menstrual bleeding; quality of life
Bioavailability Study of Doxycycline Monohydrate Capsules and Monodox Under Fasting and Fed Conditions
Condition: To Determine Bioequivalence Under Fed Conditions
MeSH terms: Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      To compare the rate and extent of absorption of doxycycline monohydrate capsules equivalent
      to 100 mg doxycycline (Par) versus Monodox (Oclassen Pharmaceuticals)
    

Detailed description: 
      To compare the rate and extent of absorption of doxycycline monohydrate capsules equivalent
      to 100 mg doxycycline by Par Pharmaceutical Inc., USA (test) versus Monodox by Oclassen
      Pharmaceuticals, Inc., USA (reference) administered as a 1 x 100 mg capsule under fasting and
      fed conditions.
    

Intervention name(s): Doxycycline monohydrate; Monodox; Doxycycline Monohydrate
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Capsules, 100 mg, fed; Capsules, 100 mg, fed; Capsules, 100 mg, fasting
Other intervention name(s): Monodox; Doxycycline Monohydrate; Monodox
Intervention MeSH terms: Doxycycline
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Bioequivalence; Doxycycline Monohydrate; Fed
The Effects of Resveratrol Supplement on Biochemical Factors and Hepatic Fibrosis in Patients With Nonalcoholic Steatohepatitis
Condition: Non Alcoholic Fatty Liver
MeSH terms: Fatty Liver; Non-alcoholic Fatty Liver Disease
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      To study the effects of Resveratrol supplement on lipid profile, liver enzymes, inflammatory
      factors and hepatic fibrosis in patients with Nonalcoholic Fatty Liver (NAfLD), 50 patients
      who referred to Gastrointestinal (GI) clinic with steatosis grade 1 or more will be randomly
      allocated to receive 1 Resveratrol capsules or placebos for 12 weeks; both groups will be
      advised to adherence our diet and exercise program too. At the first and the end of the
      intervention, lipid profiles, liver enzymes, some inflammatory cytokines, and liver fibrosis
      will be assessed and compared between groups.
    


Intervention name(s): Resveratrol; placebo
Intervention type(s): Dietary Supplement; Other
Other intervention name(s): Dietary Supplement: Resveratrol; 1 Resveratrol capsule per day for 12 weeks
Intervention MeSH terms: Resveratrol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Dose Response to Topical Glyceryl Trinitrate in Patients With Raynaud's Phenomenon
Condition: Raynaud's Phenomenon
MeSH terms: Raynaud Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the blood flow response to topical Glyceryl
      Trinitrate when applied to the skin of patient's fingers with Raynaud's Phenomenon.
    


Intervention name(s): placebo cream; Glyceryl Trinitrate; Glyceryl Trinitrate; Glyceryl Trinitrate; Glyceryl Trinitrate
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): placebo cream applied to 2 adjacent fingers of non-dominant hand one time; 0.6mg of Glyceryl Trinitrate applied to 2 adjacent fingers on non-dominant hand one time; 1.2mg Glyceryl Trinitrate topically to 2 adjacent fingers of non-dominant hand one time; 1.8mg Glyceryl Trinitrate topically to 2 adjacent fingers of non-dominant hand one time; 2.4 mg Glyceryl Trinitrate topically to 2 adjacent fingers of non-dominant hand one time
Intervention MeSH terms: Nitroglycerin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Raynaud's Syndrome; Raynaud's Disease; RP
Correlation Physiological Cost Index
Condition: Cerebral Palsy
MeSH terms: Cerebral Palsy
Study type: Interventional

Summary: 
      Objective: To compare the efficacy of a gait training program using robotic assistance
      combined with virtual reality versus robotic assistance alone on energy expenditure in
      children with cerebral palsy.

      Participants: Children with cerebral palsy levels II, III, IV, and V according to the Gross
      Motor Function Classification System (GMFCS), from different paediatric physiotherapy centres
      and schools in Valencia, Spain.

      Intervention: Gait training using an inexpensive robotic gait training system (CL1Walker) and
      participation in a virtual reality game, Treasure Hunt (abbreviated here as ACT, from the
      Spanish A la Caza del Tesoro) in the experimental group (GTVR) and gait training using the
      same robotic gait training system without using virtual reality in the control group (GT).

      Measurements: Assessment using the Physiological Cost Index (PCI) one week prior to and after
      the intervention. The intraclass correlation (ICC) replicability and the minimum detectable
      change (MDC) of the PCI.
    

Detailed description: 
      Design: Longitudinal, prospective, double blind study with two treatment groups and repeated
      measurements, controlled for the condition without virtual reality.
    

Intervention name(s): Experimental group (GTVR); Control group (GT)
Intervention type(s): Other; Other
Intervention description(s): Gait training with a robotic system (CL1Walker) combined with immersion in a Virtual Reality program; Gait training with a robotic system (CL1Walker) alone.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: physiological cost index; health-related quality of life; gait deviation index; gait analysis; cerebral palsy
Comparison of Capso Vision SV-1 to PillCam SB2 in the Evaluation of Subjects With Suspected Small Bowel Disease
Condition: Intestinal Disease; Inflammatory Bowel Disease; Crohn Disease; Ulcer; Celiac Disease
MeSH terms: Crohn Disease; Intestinal Diseases; Inflammatory Bowel Diseases; Celiac Disease
Study type: Interventional

Summary: 
      The purpose of this study is to compare the clinical findings involving the small bowel
      obtained with the Capso Vision Video Capsule Device to those results obtained with the
      PillCam SB2.
    

Detailed description: 
      This is a prospective, randomized, comparative multi-center site study. The study will be
      conducted at 5 to 10 clinical sites. Up to 120 subjects will be enrolled in the study in
      order to obtain complete endoscopic results involving at least 98 subjects.
    

Intervention name(s): PillCam SB2 capsule; CapsoCam SV-1
Intervention type(s): Device; Device
Intervention description(s): Capsule Endoscopy system; Capsule endoscopy
Other intervention name(s): capsule endoscopy system; Capsule endoscopy
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: intestinal disease; inflammatory bowel disease; crohn disease; ulcer; celiac disease; angioectasia; polyp
Effects of Trunk Stabilization Versus Activation Exercises on Pain and Disability in Postpartum Lumbo-pelvic Pain
Condition: Pelvic Pain
MeSH terms: Pelvic Pain
Study type: Interventional

Summary: 
      To compare the Effects of trunk stabilization versus activation exercises on pain and
      disability in postpartum lumbo-pelvic pain.
    

Detailed description: 
      Effects of stabilizing exercises on postpartum pelvic floor muscle function, lumbo-pelvic
      pain and disability. In results, stability exercises can help women with LPP enhance the
      function of their PFMs. Pregnancy and childbirth weakens PFMs and disrupts the load-transfer
      system in the lumbo-pelvic area. The use of PFMs in the right pattern can help these muscles
      operate better. Local stabilizing muscles are targeted during stabilization exercises, which
      increase pelvic motor control and stability.

      As per researcher knowledge there was limited evidence present on the comparison of trunk
      stabilization and trunk activation exercises. Therefore, this study was conducted to find the
      effectiveness of trunk stabilization versus activation exercises on disability and pain in
      postpartum women with lumbo-pelvic pain.
    

Intervention name(s): Trunk stabilization; Activation exercises
Intervention type(s): Other; Other
Intervention description(s): Trunk stabilization exercises with
Static back: A roll of towel was pressed against the back and the position was held for 10 secs and then released
Static gluteus: The gluts were pressed inside and hold for 10 secs and then released.
Abdominal bracing: Brace your abdomen by contracting your entire abdomen. From here Perform different exercises such as raising your arms and then raising your legs.
Pelvic bridging: In crook lying, engage your gluts and trunk lift your hips towards the ceiling. Hold the position for 10 secs and then release.
SLR with-hold at 30 and 45 degrees: Ask the supine patient to raise the leg up-to 45 degrees and hold for 10 secs. Then raise the leg up-to 30 degrees then hold for 10 secs.; Activation exercises with
Upper rectus abdominis (URA) and lower rectus abdominis (LRA): body supine with hips and knees flexed 90°, with feet locked. Participants flexed the trunk (i.e. crunch execution) against resistance at the level of the shoulders..
External oblique (EO) and internal oblique (IO): side-lying with the hip at the edge of the bench and feet locked by a second operator. Participants performed side-bend exercise against resistance at the level of the shoulder.
Lower erector spinae (LES) and upper erector spinae (UES): prone position with ASIS at the edge of the bench and feet locked by a second operator. Participants performed a back extension against resistance at the level of the shoulders.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Lumbo-pelvic Pain; Postpartum; Stabilization Exercises; Trunk Activation Exercises
Safety and Efficacy of Drug Combinations Against Triple Infections
Condition: Parasitic Diseases
MeSH terms: Parasitic Diseases
Study type: Interventional

Summary: 
      This randomised, controlled, double blinded clinical study investigates the safety and
      efficacy of the combination of albendazole, ivermectin and praziquantel in the treatment of
      children aged 5-18 years co-infected with lymphatic filariasis, schistosomiasis and
      soil-transmitted helminthiasis.
    


Intervention name(s): albendazole + ivermectin + praziquantel; albendazole + ivermectin + (1 week later) praziquantel
Intervention type(s): Drug; Drug
Intervention description(s): albendazole (400 mg one dose) + ivermectin 200 microgram/kg body weight) + praziquantel (40 mg/kg); albendazole (400 mg one dose) + ivermectin (200 microgram/kg body weight) + (1 week later) praziquantel (40 mg/kg)
Intervention MeSH terms: Ivermectin; Albendazole; Praziquantel
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Glycemic Index and Glycemic Response of Food and Products
Condition: Healthy
Study type: Interventional

Summary: 
      The purpose of ths study was to evaluate the glycemic index and glycemic response of food and
      products that produced in Tiwan. The food and product are in includes local produced fruits,
      starchy food and bread made from resistant starch.
    

Detailed description: 
      Low glycemic index (GI) diets have protective and therapeutic potential for diabetic patients
      and general public. With recent recognition of resistant starch (RS), an indigestible
      fraction which has postprandial glucose lowering effects, the addition of resistant starch in
      bread may alter its glycemic effects and thus glycemic index. Therefore, the objectives of
      this study were to investigate the glycemic index, glycemic reponse of Taiwan local food and
      effects of resistant starch in bread formulation.
    

Intervention name(s): test food
Intervention type(s): Other
Intervention description(s): All food, include reference food was tested in 50g available carbohydrate portion size.
Other intervention name(s): Starchy food; Taiwan local fruits; White bread; White bread with resistant starch
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: glycemic index, resistant starch, glycemic response
Analysis of Postural Control in Children Suffering From Triceps Suralis Shortening.
Condition: Ankle Disease
Study type: Interventional

Summary: 
      The central nervous system (CNS) coordinates balance through the visual, vestibular, and
      somatoproprioceptive systems, which produce muscle activation for postural control. Among the
      important muscle activations for postural control are those produced in the ankle joint,
      which is crucial for maintaining postural control in sports settings, along with the
      gastrocnemius and soleus muscles. Studies show that children who practice sports improve
      their postural stability and accelerate sensory maturation, which can affect the development
      of the lower limb extremity, specifically the insertional musculature of the ankle and foot.
      The present study aims to analyze postural control in school-aged children with triceps
      suralis retraction and assess the effectiveness of treatment with stretching versus a heel
      pad for 3 and 6 months. Additionally, the study will analyze whether the physical activity
      the children engage in influences their stability
    

Detailed description: 
      A randomized controlled trial will be conducted to evaluate the effectiveness of using a heel
      pad and a gastrocnemius and soleus stretching protocol. The outcomes of both interventions
      will be evaluated and compared, including pre-intervention and post-intervention assessments
      at 3 months and 6 months.
    

Intervention name(s): Streching Group; Heel group
Intervention type(s): Procedure; Procedure
Intervention description(s): The Streching group will perform a conventional stretching exercise.; The heel pad group will be applied a plantar support during the months of the study.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Muscle Stretching Exercises; Balance; Exercise; Range of Motion
Ultrasonography Assessment of Peripheral Entheses in Axial Spondyloarthritis and in Healthy Subjects, Athletes or Not
Condition: Peripheral Entheses
MeSH terms: Spondylitis; Spondylarthritis; Axial Spondyloarthritis
Study type: Interventional

Summary: 
      Purpose:

        -  Assessment of ultrasound MASEI index in axial spondyloarthritis and in healthy subjects,
           athletes or not

        -  Comparison of the ultrasound semiology of enthesitis in the 3 populations

        -  Comparison of the MASEI scores in the 3 populations
    


Intervention name(s): BLOOD SAMPLES; Radiographs of the sacroiliac joints; Radiographs of heels; SCAN
Intervention type(s): Biological; Device; Device; Device
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Effect of Nutrition on Muscle Protein Synthesis
Condition: Healthy
Study type: Interventional

Summary: 
      The present proposal is designed to examine the effect of carbohydrate and protein
      co-ingestion on muscle protein synthesis during endurance type exercise activities. We
      hypothesize that muscle protein synthesis is higher when protein is co-ingested during
      exercise.
    


Intervention name(s): carbohydrate and protein
Intervention type(s): Dietary Supplement
Intervention description(s): The intake of carbohydrate and protein during endurance type exercise
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: muscle protein synthesis; whole-body protein breakdown; nutrition
A Study of KW-6356 in Patients With Parkinson's Disease on Treatment With Levodopa-containing Preparations
Condition: Parkinson's Disease
MeSH terms: Parkinson Disease
Study type: Interventional
Phase: Phase 2

Summary: 
      The primary objective of this study is to determine the recommended dose and evaluate the
      effect of KW-6356 on motor symptoms in Parkinson's disease and the primary endpoint is the
      change from baseline in Movement disorder society-unified Parkinson's disease rating
      scale(MDS-UPDRS) partIII score between KW-6356 and placebo in patients with Parkinson's
      disease on treatment with Levodopa-containing preparations as an adjunctive therapy.
    


Intervention name(s): KW-6356; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Oral administration; Oral administration
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: An interventional, multicenter, randomized, double-blind, placebo-controlled, parallel-group trial
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Clinical Trials on Evaluate the Red Ginseng and Fermented-Red Ginseng Affect to Drug Metabolizing Enzyme and Transporter in Healthy Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the possibility of drug interactions before and
      after taking red ginseng or fermented-red ginseng by estimating metabolic rate of indicator
      drugs for cytochrome P450 and P-glycoprotein.
    


Intervention name(s): CYP cocktail; Fexofenadine 30mg; Red ginseng; Fermented-red ginseng
Intervention type(s): Drug; Drug; Dietary Supplement; Dietary Supplement
Intervention description(s): Each group administered CYP cocktail (Caffeine 200mg + Losartan 50mg + Omeprazole 20mg + Dextromethorphan 30mg + Midazolam 7.5mg) under fasting conditions.; Each group administered Fexofenadine 30mg under fasting conditions.; During 4~17th days, end of the period 1, the group of red ginseng administered red ginseng extract.; During 4~17th days, end of the period 1, the group of fermented-red ginseng administered fermented-red ginseng extract.
Other intervention name(s): Caffeine 200mg; Losartan 50mg; Omeprazole 20mg; Dextromethorphan 30mg; Midazolam 7.5mg
Intervention MeSH terms: Fexofenadine; Losartan; Midazolam; Dextromethorphan; Caffeine; Omeprazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
A Open-label Food Effect Study With SEN0014196 in Subjects With Huntington Disease
Condition: Huntington's Disease
MeSH terms: Huntington Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary purpose of this study is to assess the effect of food upon the pharmacokinetics
      (PK) of SEN0014196 in subjects with Huntington disease (HD).
    

Detailed description: 
      In addition to the pharmacokinetic endpoints, the study will assess the safety and
      tolerability of 100 mg once daily (qd) doses of SEN0014196 over 14 days in subjects with HD
      and explore potential biomarkers for use in subsequent Phase 2/3 studies.
    

Intervention name(s): SEN0014196
Intervention type(s): Drug
Intervention description(s): 100 mg, immediate release tablets, once daily administration
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Huntington Disease; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Dementia; Chorea; Dyskinesias; Movement Disorders; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Genetic Diseases, Inborn; Cognition Disorders; Mental Disorders
Periodontal Treatment and Psychology
Condition: Gum Disease
MeSH terms: Gingival Diseases; Periodontal Diseases
Study type: Interventional

Summary: 
      There is a relationship between depression and periodontal disease. This relationship may be
      double-sided. A psychological state such as anxiety, depression, body image, and self-esteem
      may be affected from the symptoms of periodontal disease.
    

Detailed description: 
      Background: Depression is a multi-factorial disease characterized by a variety of symptoms.
      Psychiatric disorders seem to be more prone to periodontitis compared to patients without
      psychiatric disorders. However periodontal disease and depression can be considered
      bidirectional risk factors. Periodontal disease can also be an effect on depression. The aim
      of this randomized controlled clinical study is to determine the effect of non-surgical
      mechanical periodontal treatment on psychological state.

      Material and methods: The study population consisted of 184 depressed patients with
      non-treated periodontal diseases. Two randomized group is formed from these patients.
      Immediately periodontal treatment (test group, n = 92) and delayed periodontal treatment
      (control group, n = 92). Clinical periodontal and psychological measures were performed at
      baseline and 6th weeks on control and test group.
    

Intervention name(s): Psychological measurements
Intervention type(s): Other
Intervention description(s): Four questionnaire tests for depression, body image, self-esteem, and anxiety was performed baseline and after 6 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Periodontal disease; depression; body image; self-esteem