bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Long Biliopancreatic Limb vs. Long Alimentary Limb in Superobesity, a Randomized Study
Condition: Morbid Obesity; Weight Loss
MeSH terms: Obesity; Obesity, Morbid; Weight Loss
Study type: Interventional

Summary: 
      Super Obesity, i.e. a BMI above 50, is difficult to treat. Normal gastric bypass surgery is
      not always enough for proper weight control. Bypassing a longer segment of the gut may be
      more beneficial. Which part to bypass is not clear.

      The investigators want to compare the effects between preventing a 60 cm proximal (oral)
      portion of the jejunum from food contact with the effects when preventing a 200 cm part of
      the jejunum from contact with bile and pancreatic juice.

      Endpoints are quality of life, gastrointestinal function, and weight development.
    

Detailed description: 
      Two variations of gastric bypass are compared:

      Method 1 (test method):A 200 cm BP-limb (distance Treitz to EA) + 150 cm common channel (EA
      to ileocecal valve) + Roux-Y-limb variable Method 2 (standard method): A 60 cm BP limb + 150
      cm Roux-Y-limb + common channel variable.

      Patients are evaluated according to the principles of the Scandinavian Obesity surgery
      registry (SOReg) with the addition of two additional questionnaires.

      FU time is set at 5 years.
    

Intervention name(s): gastric bypass
Intervention type(s): Procedure
Intervention description(s): two techniques of gastric bypass for studying the effects of making a long BP-limb
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomised study between long and standard biliopancreatic limb in gstric bypass surgery
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: gastric bypass; morbid obesity; gut function; weight loss
Blood Sample Collection in Geriatric Patients
Condition: Venipuncture Site Bruise
Study type: Interventional

Summary: 
      This study aimed to evaluate the effect of different durations of a specific pressure applied
      after blood collection on the development of ecchymosis in geriatric patients using oral and
      subcutaneous anticoagulants.
    

Detailed description: 
      The research sample consisted of patients hospitalized in the Geriatrics Clinic of a city
      hospital. This study aimed to evaluate the effect of different durations of a specific
      pressure applied after blood collection on the development of ecchymosis in geriatric
      patients using oral and subcutaneous anticoagulants. In this study, whether ecchymosis
      developed at the 24th, 48th and 72nd hours after the blood collection procedure was
      evaluated.
    

Intervention name(s): 20 N pressure for 1 minute; 20 N pressure for 3 minute; 20 N pressure for 5 minute
Intervention type(s): Other; Other; Other
Intervention description(s): After blood collection, 20 N pressure applied for 1 minute; After blood collection, 20 N pressure applied for 3 minute; After blood collection, 20 N pressure applied for 5 minute
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Investigator)
Primary purpose: Prevention
Clinical Evaluation of Multifocal Intraocular Lens: OPTIVIS.TM
Condition: Cataract Senile; Lenses, Intraocular
MeSH terms: Cataract
Study type: Interventional

Summary: 
      This study evaluated visual outcome after cataract surgery with bilateral implantation of
      either a diffractive - refractive (hybrid) multifocal intraocular lens (MFIOL) or monofocal
      intraocular lens (IOL) as a control grup.
    

Detailed description: 
      PURPOSE: To present the outcomes of hybrid multifocal and monofocal intraocular lenses (IOL)

      SETTING: Parc de Salut Mar, Universidad Pompeu-Fabra - Autónoma, Barcelona, Spain.

      DESIGN: Prospective clinical trial.

      METHODS: Consecutive patients with bilateral cataract were included. Phacoemulsification with
      randomized implantation of either a monofocal IOL (AR40e, AMO-Abbot 30 Laboratories Inc.
      Abbot Park, Illinois, USA) or multifocal IOL (OptiVis™, Aaren Scientific, Inc, Ontario, CA,
      USA) was performed by the same surgeon and under the same conditions. Over a 3-month
      follow-up, the main outcome measures were uncorrected distance visual acuity (UDVA),
      corrected distance visual acuity (CDVA), uncorrected intermediate visual acuity at 60 cm
      (UIVA), distance-corrected intermediate visual acuity (DCIVA), uncorrected near visual acuity
      at 33 cm (UNVA), distance-corrected near visual acuity (DCNVA), spherical equivalent (SE),
      contrast sensitivity (CS), presence of dysphotopsia, use of spectacles and patient
      satisfaction with the test VF-14 (Visual Function Index) .
    

Intervention name(s): OptiVis, Aaren Scientific; Monofocal IOL
Intervention type(s): Device; Device
Intervention description(s): All the surgeries were performed under topical anesthesia using a standard phacoemulsification procedure with Infiniti Vision System (all from Alcon Laboratories, Inc, Fort Worth, TX).; All the surgeries were performed under topical anesthesia using a standard phacoemulsification procedure with Infiniti Vision System (all from Alcon Laboratories, Inc, Fort Worth, TX).
Other intervention name(s): a hybrid multifocal intraocular lens; AR40e, AMO-Abbot 30 Laboratories Inc.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Consecutive patients with bilateral cataract were included after meeting all the inclusion and none of exclusion criteria and when written informed consent was obtained from all patients.
Patients were randomly assigned to have bilateral implantation with either a monofocal IOL (AR40e, AMO-Abbot 30 Laboratories Inc. Abbot Park, Illinois, USA) or multifocal IOL (OptiVis™, Aaren Scientific, Inc, Ontario, CA, USA).
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: OptiVis; hybrid multifocal intraocular lens; multifocal intraocular lens; presbyopia
Changes in Quality of Life Following Surgical Treatment of Benign Non-toxic Goiter
Condition: Goiter
MeSH terms: Goiter
Study type: Observational

Summary: 
      The aim is to investigate the influence of surgical treatment on benign non-toxic goiter on
      the disease specific quality of life evaluated 6 months after thyroid surgery.

      All investigations follow already scheduled treatments.
    


Intervention name(s): Thyroidectomy
Intervention type(s): Procedure
Intervention description(s): Regular thyroidectomy or hemithyroidectomy through Kocher's skin incision
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        All patients undergoing hemi- or total thyroidectomy at Odense University Hospital for
        benign symptomatic non-toxic goiter
      
Keywords: Goiter; Thyroid disease; Struma
Compatibility of C7 With Ketogenic Diet in Patients Diagnosed With G1D
Condition: GLUT1DS1
Study type: Interventional
Phase: Phase 2

Summary: 
      To explore triheptanoin (C7 oil) compatibility with the ketogenic diet by evaluating EEG, and
      seizure rate, glycemia and ketosis in proven G1D patients receiving a ketogenic diet.
    

Detailed description: 
      This is a single site, open label proof of principle exploratory trial to investigate the
      compatibility of C7 oil with the ketogenic diet in subjects diagnosed with G1D. The ketogenic
      diet will have been previously described by the patient's treating physician independently of
      this study and for clinical reasons. The ketogenic diet supplies over 50% of calories from
      fat, subjects, who are already tolerating over this much fat as part of their previously
      prescribed ketogenic diet, will replace 45% of their daily caloric intake with the
      triheptanoin for 24 hours, during a 48 hour inpatient stay. Subjects will have a continuous
      EEG to monitor for any potential C7 related changes in seizure before, during, and after
      triheptanoin oil ingestion.
    

Intervention name(s): Triheptanoin
Intervention type(s): Drug
Intervention description(s): Dietary supplementation with triheptanoin
Other intervention name(s): C7 oil
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: G1D, glucose, transporter
A Study to Evaluate the Bioavailability and Safety of DNL343 in Healthy Volunteers
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a Phase 1 relative bioavailability study carried out in approximately 24 healthy male
      subjects and healthy female subjects of non childbearing potential to investigate the effects
      of formulation and food on the safety, tolerability, and pharmacokinetics (PK) of DNL343.
    


Intervention name(s): DNL343; Placebo; DNL343
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Multiple oral doses; Single oral dose; Single oral dose
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Clinical Effects of Montelukast in Patients With Perennial Allergic Rhinitis (0476-265)
Condition: Rhinitis, Allergic, Perennial
MeSH terms: Rhinitis; Rhinitis, Allergic; Rhinitis, Allergic, Perennial
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to determine the effect of an approved medication on the
      symptoms of perennial allergic rhinitis (an inflammation of the mucous membrane of the nose
      similar to that found in hay fever except that symptoms persist throughout the year), in
      patients who have a history of perennial allergic rhinitis.
    


Intervention name(s): Montelukast; Comparator: Placebo
Intervention type(s): Drug; Drug
Intervention description(s): one 10 mg tablet, taken once daily at bed time for 6 weeks; one placebo tablet, taken once daily at bed time for 6 weeks
Intervention MeSH terms: Montelukast
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Hepatic Vein-sparing Hepatectomy for Colorectal Liver Metastases at the Caval Confluence
Condition: Secondary Malignant Neoplasm of Liver
MeSH terms: Neoplasms; Liver Neoplasms
Study type: Observational

Summary: 
      Major hepatectomies are generally selected for tumors involving the hepatic vein (HV) at the
      caval confluence (CC). As alternative, HV reconstruction has been proposed. The present study
      aimed to evaluate the feasibility and safety of a HV-sparing policy guided by intraoperative
      ultrasonography (IOUS) in a cohort of patients having at least one colorectal liver
      metastasis (CLM) in contact with a HV at CC. HV section can be avoided in the large majority
      of cases thanking to CLMs detachment or to HV partial resection or reconstruction: this
      policy seems feasible, safe, reduces the need of major hepatectomies, and oncologically
      provides an adequate local control.
    


Intervention name(s): Hepatic vein-sparing hepatectomy
Intervention type(s): Procedure
Intervention description(s): HV detachment, partial resection and section on the basis of HV-CLM relationship
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patiens undergoing hepatectomy for primary and secondary liver tumors
Transbronchial Mediastinal Cryobiopsy Combined With EBUS-TBNA in the Diagnosis of Mediastinal Lesions
Condition: Mediastinal Lymphadenopathy
MeSH terms: Lymphadenopathy
Study type: Interventional

Summary: 
      The clinical study is aimed to prospectively evaluate the diagnostic accuracy and the safety
      of adding transbronchial mediastinal cryobiopsy to standard sampling in mediastinal diseases.
    

Detailed description: 
      A traditional method, endobronchial ultrasound-guided transbronchial needle aspiration
      (EBUS-TBNA) was used to be compared. The patients involved were randomly divided into two
      groups. In the experimental group, EBUS-TBMCB was performed following EBUS-TBNA while in the
      other group, EBUS-TBNA was performed respectively. The samples obtained in the two groups
      were analyzed by the pathologists. Patients were followed up for confirming the diagnosis and
      complications. The diagnostic accuracy and prevalence of procedure-related adverse events
      were compared between the 2 groups.
    

Intervention name(s): EBUS-TBMCB
Intervention type(s): Procedure
Intervention description(s): endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy was performed in experimental arm following EBUS-TBNA
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Diagnostic
Semilunar and Conventional Coronally Positioned Flap for the Treatment Gingival Recession
Condition: Gingival Recession; Root Coverage
MeSH terms: Gingival Recession
Study type: Interventional

Summary: 
      A clinical evaluation of using the semilunar coronally position flap (SCPF) compared to the
      conventional coronally advanced flap (CAF) with modification to treat class I Miller gingival
      recession. The coronally repositioned gingival margin will be stabilized by coronally
      anchored suture with composite stops on the buccal surface of the tooth using flowable
      composite. The sample size will be ten patients. Each patient has bilateral Miller Class I
      gingival recessions; one will be treated with SCPF, while the other will be treated with CAF
    

Detailed description: 
      The aim of this study is to clinically compare between the semilunar coronally positioned
      flap (SCPF) and the conventional coronally advanced flap (CAF) after applying modification in
      both techniques to treat class I Miller gingival recession. Coronally repositioned gingival
      margin will be stabilized by coronally anchored suture with composite stops on the buccal
      surface of tooth using flowable composite for the treatment of gingival recession. Ten
      patients who have bilateral maxillary buccal Miller Class I gingival recession defects will
      be enrolled in this study. These defects will be distributed randomly into two groups: the
      test group (SCPF) and control group (CAF). Clinical parameters will be evaluated: visible
      plaque index (VPI), sulcus bleeding index (SBI), probing depth (PD), gingival recession
      height (GRH), gingival recession width (GRW), clinical attachment level (CAL), width of
      keratinized tissue (WKT), thickness of keratinized tissue (TKT), change in the position of
      muco-gingival junction, vestibular depth, wound healing index (WHI), the percentage of root
      coverage (RC) and root coverage esthetic score (RES) system. A questionnaire will be given to
      each patient, which includes evaluation of the pain intensity, root sensitivity, and
      satisfaction with aesthetic by using the visual analog scale (VAS) and questions about the
      number of analgesic pills consumed per day.
    

Intervention name(s): semilunar coronally positioned flap; coronally advanced flap
Intervention type(s): Procedure; Procedure
Intervention description(s): The description of this intervention has been already given before; The description of this intervention has been already given before
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Split-mouth design, i.e. the right side will receive the first intervention, whereas the other side (the left side) will receive the second intervention.
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: gingival recession; semilunar coronally flap; coronally advanced flap
Determination of Postprandial Glycemic Responses by Continuous Glucose Monitoring in a Real-World Setting
Condition: Postprandial Glucose Response; Glycaemic Index; Continous Glucose Measurement
Study type: Interventional

Summary: 
      Self-monitoring of blood glucose using capillary glucose testing has a number of shortcomings
      compared to continuous glucose monitoring (CGM). We aimed to compare these two methods and
      used blood glucose measurements in venous blood as a reference. Despite considerable
      inter-individual variability of postprandial glycemic responses, CGM evaluated postprandial
      glycemic excursions which had comparable results compared to standard blood glucose
      measurements under real-life conditions.
    

Detailed description: 
      Self-monitoring of blood glucose using capillary glucose testing (C) has a number of
      shortcomings compared to continuous glucose monitoring (CGM). We aimed to compare these two
      methods and used blood glucose measurements in venous blood (IV) as a reference. Postprandial
      blood glucose levels were measured after 50 g oral glucose load and after the consumption of
      a portion of different foods containing 50 g of carbohydrates. We also evaluated the
      associations between postprandial glucose responses and the clinical characteristics of the
      participants at the beginning of the study. Incremental area under the curve (AUCi) of
      postprandial blood glucose was calculated for 1 h (AUCi 0-60) and 2 h (AUCi 0-120). Despite
      considerable inter-individual variability of postprandial glycemic responses, CGM evaluated
      postprandial glycemic excursions which had comparable results compared to standard blood
      glucose measurements under real-life conditions.
    

Intervention name(s): Determination of postprandial glucose response by continuous glucose measurement after consuming different carbohydrate containing foods
Intervention type(s): Device
Intervention description(s): One day prior to the study beginning, participants were equipped with a CGM system (FreeStyle Libre®, Abbott Diabetes Care, Alameda, CA, USA). This CGM system provides glucose recordings every 15 min over a period of 14 days. The glucose data were downloaded manually by a scan with a handheld device.
On the second day of the study, participants consumed portions of these three test products containing 50 g of available carbohydrate on 3 separate days without a washout period. The products were tested in random order at the same time of the morning after a 10 h overnight fast. Venous blood samples were collected at 0, 15, 30, 45, 60, 75, 90, 105 and 120 min postprandial by inserting an intravenous cannula into a forearm vein. Capillary blood samples were obtained through finger pricking. Blood glucose levels in these samples were measured with a high quality SMBG system (ContourXT/Contour next, Ascensia Diabetes Care, Leverkusen, Deutschland, Germany).
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Mode Specific Effects of Isokinetic Training of Hamstring on Hamstring to Quadriceps Ratio
Condition: Muscle Strength
Study type: Interventional

Summary: 
      Mode specificity of eccentric and concentric isokinetic training have been examined in
      previous studies but with conflicting results. The present study aimed to examine the
      mode-specific effects of eccentric and concentric isokinetic training of hamstring muscle at
      slow angular velocity on eccentric peak torque of hamstring (PTecc), concentric peak torque
      of quadriceps (PTcon), acceleration time of hamstring (AThams) and quadriceps (ATquad),
      deceleration time of hamstring (DThams) and quadriceps (DTquad), time to peak torque of
      hamstring (TPThams) and quadriceps (TPTquad), and functional Hamstring-to-Quadriceps ratio
      (PTecc/PTcon).
    

Detailed description: 
      Several studies in past have tried to examine the mode specificity of concentric and
      eccentric training of different muscles and at different angular velocities i.e. whether
      concentric training will increase the concentric strength only or both concentric and
      eccentric strength and whether eccentric training will increase eccentric strength only or
      both eccentric and concentric strength.

      Since conflicting reports are available regarding mode specificity of eccentric and
      concentric isokinetic training therefore one study was needed that can examine the mode
      specificity of these training in hamstring muscles at slow angular velocity. The present
      study aimed to examine the mode-specific effects of six weeks of isokinetic concentric and
      eccentric training of the hamstring muscle at slow angular velocity on the PTecc/PTcon, AT,
      DT, and TPT.
    

Intervention name(s): Eccentric isokinetic training; Concentric isokinetic training
Intervention type(s): Other; Other
Intervention description(s): Eccentric exercises of the hamstring muscles were performed with the use of an isokinetic dynamometer device.; Concentric exercises of the hamstring muscles were performed with the use of an isokinetic dynamometer device.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants were randomly divided into two groups.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Isokinetic training; peak torque; acceleration time; deceleration time; time to peak torque; Hamstring-to-Quadriceps ratio
Audiological Benefit and Improved Quality of Life With Two Bone Conduction Systems: ADHEAR vs. Bonebridge in Experienced Users
Condition: Bone Conduction Deafness; Hearing Loss, Conductive
MeSH terms: Hearing Loss; Deafness; Hearing Loss, Conductive
Study type: Interventional

Summary: 
      Patients implanted with a Bonebridge will be asked to be part of the study. The study
      subjects are enrolled into the study according to inclusion criteria.

      Patients will be asked to wear an adhesive bone conduction device an adapt to it for 30-60
      min. After this time period patients will be asked to use the adhesive device instead of the
      Bonebridge for 3 weeks. Audiologic Tests and quality of life questionnaires will be assessed
      at the beginning of the study and at the end of three weeks.
    

Detailed description: 
      Phase 1 Patients will be fitted with an adhesive bone conduction device and asked to fill out
      two questionnaires. They will then wear the device for 30-60 minutes and decide if they want
      to wear the device for the remaining study time of three weeks. Patients who do not have
      sufficient benefit from the device or do not feel comfortable with it do not enter the second
      study period of wearing the device for three weeks. Patients will be asked to comment on
      their experiences after 30 to 60 minutes explaining why they do not want to enter the second
      part of the study if they feel comfortable sharing this information. Phase 2 Patients, in the
      second study period, will be asked to wear the hearing device as long as comfortable to them
      every day and mark time of device usage, battery life, changes of the adhesive adapter, sound
      quality and comfort related remarks in a diary. After three weeks patients will return to the
      outpatient ́s department for an audiological assessment and a second set of quality of
      hearing and quality of life questionnaire.

      No patients will be implanted with a Bonebridge as part of the study.

      Audiologic testing consists of sound field audiometry, Freiburg monosyllables test and
      Oldenburg sentence test.

      Questionnaires consist of the AQol-8D and the SSQ-12
    

Intervention name(s): Adhesive bone conduction hearing aid (ADHEAR - Med El)
Intervention type(s): Device
Intervention description(s): Patients are asked to wear an adhesive bone conduction hearing device which is attached to the mastoid with an adhesive adapter
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Hearing aid