Transdiagnostic Markers of Cognitive Symptoms in Disorders Affective.
Condition: Major Depressive Disorder; Bipolar Disorder; BDMF; GSH; Neurologic Manifestations
MeSH terms: Neurobehavioral Manifestations; Neurologic Manifestations; Depressive Disorder; Depressive Disorder, Major; Bipolar Disorder
Study type: Observational

Summary: 
      The objective of this project is to determine the concordance between the subjective and
      objective evaluation of cognitive functions in affective patients in partial remission
      through scales and cognitive tests that would be easily implemented in the different mental
      health care devices.

      This is a cross-sectional case-control study of non-probabilistic sampling, which will
      include a group of patients diagnosed with Major Depressive Disorder and Bipolar Disorder and
      a group of healthy controls from the same population and matched by age, gender and years of
      education with the group of patients.

      Patients will be recruited from the psychiatric service of the Hospital de la Santa Creu i
      Sant Pau who meet the inclusion criteria, and they will undergo a blood draw, a clinical
      assessment, a complete neuropsychological examination together with scales of subjective
      perception of cognitive deficit, a measure of cognitive reserve and an evaluation of
      psychosocial functionality. In addition, the same evaluation will be made to a group of
      healthy subjects.The total sample will be 120
    

Detailed description: 
      This is a cross-sectional study with the following hypotheses and objectives:

        1. Patients will show an objective cognitive deficit with both subjective and objective
           measures compared to healthy controls.

        2. Subjectively and objectively assessed cognitive deficits will show moderate agreement in
           patients with a depressive episode in partial remission, as each assesses different
           aspects of cognition.

        3. Both the subjective and the objective assessment will have a high agreement between
           patients with DM and TB, demonstrating the transdiagnostic nature of self-assessed and
           heteroassessed cognitive deficits.

        4. Cognitive Reserve will be a mediating factor in the correlation between subjective and
           objective cognitive evaluation.

        5. BDNF and GSH will be associated with the patients' cognitive deficit and will act as
           mediators between the subjective and objective assessment.

      Main Objective:

      To study the impact of cognitive reserve and trophic factors and oxidative stress as
      transdiagnostic markers of cognitive symptoms (subjective and objective) in patients with DM
      and TB.

        1. Cognitively assess patients with DM and TB (in a depressive episode) through subjective
           assessment and objective assessment.

        2. Evaluate the possible implementation of objective (SCIP) and subjective (COBRA, PDQ)
           cognitive assessment instruments.

        3. Determine the degree of agreement between both types of cognitive assessment both
           intra-patient and inter-diagnostic.

        4. Determine the factors associated with the degree of agreement between both assessments
           (Cognitive Reserve, BDNF and GSH) in and between both affective disorders.
    

Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        The study population will be patients with major depressive disorder and bipolar disorder.
        In addition, a control group with healthy subjects matched by age, educational level and
        sex will be included.
      
Biospecimen description: 
      Blood sampling of peripheral inflammatory markers.