bioihbjkbjnl/mcl2 huggingface dataset:
Strengthening Exercises Versus Proprioception and Balance Exercises in the Treatment of Knee Osteoarthritis
Condition: Osteo Arthritis Knee; Pain
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional

Summary: 
      The aim of the study is to investigate and compare the effect of balance and proprioception
      exercises with strengthening exercises on muscle strength, pain, proprioception, function and
      quality of life in knee osteoarthritis patients.
    

Detailed description: 
      Damage or loss of mechanoreceptors in osteoarthritis patients affects balance and
      proprioception. There are studies showing that proprioceptive deficit is associated with the
      onset and progression of knee osteoarthritis leading to pain and disability. Because the
      proprioception provides a sense of power generation and allows the power output to be better
      regulated. When the literature is examined, studies investigating the effects of
      proprioception and balance exercises on muscle strength, function and pain are limited.

      In our study patients will be randomly divided into two groups: Group I (Proprioception and
      Balance) and Group II (muscle strengthening exercises). While Group I will be applied
      Proprioception and Balance training exercises, Group II will be applied closed and open
      kinetic strengthening exercises. Two group will perform exercise 3 times a week during 8
      weeks.
    

Intervention name(s): Proprioception and Balance Program; Strengthening Program
Intervention type(s): Other; Other
Intervention description(s): Balance Trainer device and playing ball in tandem position for using to improve balance, vibration and reposition exercises for using to improve proprioception. Progressive of training will increase after each 2 weeks.Patients will be taken to the treatment program 3 days in a week for 8 weeks.; Exercises which include open and closed kinetic chain exercise will be applied to strength knee and hip muscle. Progressive of training will increase after each 2 weeks. Patients will be taken to the treatment program 3 days in a week for 8 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Rehabilitation; Pain; Functionality; Proprioception
A Chart Review to Evaluate the Safety and Efficacy of MeRT on Subjects With ASD
Condition: Autistic Disorder
MeSH terms: Autistic Disorder
Study type: Observational

Summary: 
      The purpose of this study is to evaluate the safety and efficacy of Magnetic EEG/ECG-Guided
      Resonance Therapy (MeRT) on subjects with Autism Spectrum Disorder (ASD).
    

Detailed description: 
      This is a retrospective chart review of 200 consecutive charts of subjects ages 2-20 years
      old seen at the Brain Treatment Center between 2010 and 2015. The review is designed to
      evaluate the safety and efficacy of Magnetic
      Electroencephalogram/Electrocardiogram(EEG/ECG)-Guided Resonance Therapy (MeRT) on subjects
      with Autism Spectrum Disorder (ASD).
    

Intervention name(s): MeRT Efficacy Chart Review
Intervention type(s): Other
Intervention description(s): There will be not intervention. This is a chart review.
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Two hundred (200) male and female subjects of any ethnic background between the ages of
        2-20 years old seen at the Brain Treatment Center between 2010 and 2015. Twenty (20) male
        and female subjects of any ethnic background between the ages of 2-20 years old with
        neurotypical EEGs will be selected for comparison to the ASD group.
      
Keywords: Autism, chart review, transcranial magnetic stimulation (TMS)
Comparative Study Between Oxytocin Versus Tranexamic Acid and Ethamsylate
Condition: Blood Loss, Surgical; Blood Loss, Postoperative
MeSH terms: Hemorrhage; Blood Loss, Surgical; Postoperative Hemorrhage
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Comparative Study Between Oxytocin Versus Tranexamic Acid and Ethamsylate, Pre-operative
      Administration.
    

Detailed description: 
      Caesarean Delivery commonly referred to as caesarean section and occasionally caesarean birth
      is defined as the delivery of a foetus(es) through surgical incisions made through the
      anterior abdominal wall (technically referred to as laparotomy) and the anterior uterine wall
      (technically denoted to as hysterotomy).

      Obstetric Hemorrhage (Intra operative OR post operative bleeding)is still the major cause of
      maternal morbidity and mortality worldwide contributing to nearly 25% of direct maternal
      deaths. And accounts for 50% of maternal mortality in low-income countries.

      So many Strategies reducing the intraoperative blood loss or post operative blood loss could
      be helpful in decreasing the risks of blood transfusion and the postoperative maternal
      morbidity.

      So these Medications are such as Oxytocin, Carbetocin, Misoprostol, Prostaglandin F2 alpha,
      methylergonovine, Tranexamic acid and Etamsylate . have been tried before to control bleeding
      during and after Cesarean Section.
    

Intervention name(s): Oxytocin ,Tranexamic acid and Ethamsylate
Intervention type(s): Drug
Intervention description(s): Is to compare blood loss during elective cesarean section intraoperative and postoperative in cases receiving Oxytocin versus Tranexamic acid and Ethamsylate
Other intervention name(s): Syntocinon , Kapron; Dicynon
Intervention MeSH terms: Tranexamic Acid; Ethamsylate; Oxytocin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: blood loss; Cesarean Section; Oxytocin; Tranexamic acid(Kapron); Etamsylate(Dicynon).
Bioequivalence Study of Guaifenesin and Pseudoephedrine Hydrochloride Extended Release Tablets 1200/120 mg Under Fasting Conditions
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This is an open label, balanced, randomized, two-treatment, two-period, two-sequence, single
      dose, crossover, oral bioequivalence study in healthy, adult, human subjects under fasting
      conditions.
    

Detailed description: 
      An open label, balanced, randomized, two-treatment, two-period, two-sequence, single dose,
      crossover, oral bioequivalence study of Guaifenesin and Pseudoephedrine Hydrochloride
      Extended Release Tablets 1200/120 mg of Dr. Reddy's Laboratories Ltd., India comparing with
      Mucinex D (Guaifenesin and Pseudoephedrine Hydrochloride) extended-release bi-layer tablets
      1200/120 mg of Reckitt Benckiser Inc., USA in healthy, adult, human subjects under fasting
      conditions.
    

Intervention name(s): Guaifenesin and Pseudoephedrine Hydrochloride Extended Release Tablets 1200/120 mg
Intervention type(s): Drug
Other intervention name(s): Mucinex D
Intervention MeSH terms: Phenylpropanolamine; Pseudoephedrine; Ephedrine; Guaifenesin; Chlorpheniramine, phenylpropanolamine drug combination
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Evaluation of the Effects of Cannabidiol (CBD) Compared to Delta-9-Tetrahydrocannabinol (THC) and Alprazolam
Condition: Cannabis Use Disorder
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the abuse potential of CBD to determine whether it
      should remain as a Schedule I drug under the Controlled Substances Act, or be recommended for
      decontrol.
    

Detailed description: 
      This is a single-dose, randomized, double-blind, placebo- and active-controlled crossover
      study that evaluates CBD in comparison with THC, alprazolam, and placebo in healthy
      recreational drug users.
    

Intervention name(s): THC; Alprazolam; Placebo oral capsule; CBD
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): THC capsule; Alpraxolam capsule; Sugar pill capsule; CBD capsule
Other intervention name(s): Xanax; Placebo
Intervention MeSH terms: Alprazolam
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Diagnostic
Flatbush FHC Proactive Colorectal Cancer Screening and Navigation
Condition: Colorectal Cancer
MeSH terms: Colorectal Neoplasms
Study type: Interventional

Summary: 
      The proposed study is a randomized controlled pilot trial designed to assess the
      effectiveness and acceptability of a proactive screening outreach program on colorectal
      cancer screening rates on eligible patients in the Flatbush Family Health Center medical
      practice.
    

Detailed description: 
      The proposed study is a randomized controlled pilot trial designed to assess the
      effectiveness and acceptability of a proactive screening outreach program on colorectal
      cancer screening rates on eligible patients in the Flatbush Family Health Center medical
      practice, which provides free and subsidized health services to underrepresented minorities.
      The investigators will randomize patients to the proactive screening outreach arm which will
      include mailed letters providing patients with information regarding their eligibility for
      and instructions for performing colorectal cancer screening with FIT testing or colonoscopy.
      Colorectal cancer screening rates via FIT testing or colonoscopy will be compared in the
      proactive outreach group and the usual care group. The investigators hypothesize that rates
      of colorectal cancer screening will improve in underserved populations with the
      implementation of a proactive approach that incorporates a mailed outreach invitation to
      screen, followed by active assistance to a colonoscopy completion if preferred or indicated.
    

Intervention name(s): Proactive CRC Screening Outreach; Usual Care
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Proactive approach that incorporates a mailed outreach invitation to screen with fecal immunochemical testing (FIT), followed by active assistance to colonoscopy completion if preferred or indicated by FIT test result.; Participants will not receive additional outreach from the study team regarding CRC screening.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Screening
Response of Alkylresorcinols to Different Cereals
Condition: Healthy
Study type: Interventional

Summary: 
      Cereal grains contain a wide variety of different phytochemicals which may play different
      roles in physiology. Their response in plasma and urine after a meal is poorly defined for
      most cereals. This study will investigate the plasma response and urinary excretion of cereal
      compounds after eating 6 different types of cereal preparation, with a focus on
      alkylresorcinols.
    

Detailed description: 
      This was a cross-over, randomized, double blind study with 6 arms (flours of different
      composition). Thirteen subjects completed the trial, where 100 g of each flour, mixed with
      300 mL milk, was fed to all subjects.
    

Intervention name(s): Refined wheat flour; Esterase wholegrain wheat flour; Wholegrain wheat flour; Liquid whole grain wheat flour; Wholegrain barley flour; Liquid wholegrain barley flour
Intervention type(s): Other; Other; Other; Other; Other; Other
Intervention description(s): A treated cereal flour mixed with milk.; A treated cereal flour mixed with milk.; A treated cereal flour mixed with milk.; A treated cereal flour mixed with milk.; A treated cereal flour mixed with milk.; A treated cereal flour mixed with milk.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Cereals; Alkylresorcinols; Betaine; Phenolics; Plasma and urine cereal phytochemicals
Effect of Parecoxib Sodium and Flurbiprofen Injection on Postoperative Shivering
Condition: Postoperative Shivering
Study type: Interventional
Phase: Phase 4

Summary: 
      Shivering is an early postoperative complication during the postoperative recovery period,
      and there is no clear consensus about the best way for its prevention. The aim of the study
      was to compare the efficacy and accompanying side effects of prophylactic flurbiprofen with
      that of parecoxib or placebo for reducing postoperative shivering.
    

Detailed description: 
      154 patients with American Society of Anesthesiologists physical status I-II, who were
      scheduled for colorectal operation under general anesthesia, were randomly assigned to
      receive flurbiprofen (Group F), parecoxib sodium (Group P ) or normal saline(Group S)40min
      before the end of surgery. Hemodynamic parameters were monitored. The occurrence of shivering
      postoperative nausea and vomiting were recorded during the recovery period. And visual
      analogue score (VAS) and ramsy sedation scale (RSS) were also recorded.
    

Intervention name(s): parecoxib sodium; flurbiprofen; saline
Intervention type(s): Drug; Drug; Drug
Intervention description(s): parecoxib sodium 40mg; flurbiprofen 50mg; normal saline
Intervention MeSH terms: Flurbiprofen; Parecoxib
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: flurbiprofen; Parecoxib sodium; Postoperative Shivering
Efficacy and Safety of THR-4109 in Obese Subjects
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate the safety and effect of THR-4109 on weight loss in
      obese subjects over a 24-week treatment period.
    


Intervention name(s): THR-4109; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): THR-4109 maximum dose in study is 115 mg via oral capsule daily in a.m. and 115 mg via oral capsule daily in p.m. for 24 weeks; Oral capsules daily in a.m. and in p.m. for 24 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Obesity; Weight Loss
Evaluate the Efficacy and Safety of ABT-126 in Subjects With Mild to Moderate Alzheimer's Disease
Condition: Alzheimer's Disease
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 2

Summary: 
      This is an efficacy and safety study evaluating a new treatment for subjects with mild to
      moderate Alzheimer's disease.
    

Detailed description: 
      This is a Phase 2 study designed to evaluate the efficacy and safety of ABT-126 in
      approximately 410 adults with mild to moderate Alzheimer's disease. Subjects will be
      randomized to one of 5 treatment groups (ABT-126, donepezil or placebo) for a 24-week
      treatment period.
    

Intervention name(s): placebo; donepezil; ABT-126
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Placebo Comparator; Active Comparator; low dose, middle dose, high dose
Intervention MeSH terms: Donepezil
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Promoting Health in Pregnancy and Postpartum
Condition: Obesity; Pregnancy; Overweight
MeSH terms: Overweight
Study type: Interventional

Summary: 
      The purpose of this study is to examine the impact of a lifestyle intervention on gestational
      weight gain, postpartum weight loss, and other secondary outcomes relative to a usual care
      control group.
    

Detailed description: 
      Our study will address the following specific aims: (1) examine the impact of a lifestyle
      intervention on gestational weight gain and postpartum weight loss in overweight and obese
      women, (2) examine the impact of the intervention on physical activity (PA), dietary intake,
      and quality of life (QOL), (3) examine race differences in total gestational weight gain, PA,
      dietary intake, and QOL; and (4) examine the impact of the intervention on offspring
      adiposity.
    

Intervention name(s): Lifestyle Intervention; Standard Care
Intervention type(s): Behavioral; Behavioral
Intervention description(s): During pregnancy, participants complete one face-to-face counseling session, receive 10 behavioral podcasts, and receive weekly phone calls until delivery. Participants will be asked to attend one group session on breastfeeding. Participants will have the opportunity to participate in a private Facebook group during pregnancy and postpartum. During postpartum, participants complete one face-to-face counseling session, receive 16 behavioral podcasts, receive brief weekly check-in telephone calls for six weeks, and receive up to 8 telephone counseling calls through 6 months after delivery.; Women will receive standard nutrition counseling provided by physicians, nurses, nutritionists, and counselors from the Women, Infants, and Children (WIC) program (if applicable). They will receive a monthly study mailing that is educational in nature as well as podcasts related to a healthy pregnancy. During pregnancy, the mailings will focus on tips for a healthy pregnancy and on fetal development. During postpartum the mailings will focus on infant development and parenting. We will select a matched number of podcasts from Pea in the Podcast, commercially available podcasts. All mailings and podcasts will avoid discussion of weight, PA, or diet (except for foods to avoid in pregnancy for safety reasons).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: Gestational weight gain; Lifestyle intervention; Pregnancy; Postpartum; Physical activity; Nutrition
SpO2 Accuracy of Noninvasive Pulse Oximeter Sensor
Condition: Healthy; Hypoxia
MeSH terms: Hypoxia
Study type: Interventional

Summary: 
      The purpose of this clinical study is to validate the SpO2 accuracy of the Stryker
      Sustainability Solutions pulse oximetry sensors during non-motion conditions over the range
      of 70-100% SaO2 as compared to arterial blood samples assessed by CO-Oximetry. The end goal
      is to provide supporting documentation for the SpO2 accuracy validation of the reprocessed
      sensors.
    

Detailed description: 
      In this study, the level of oxygen within the blood will be reduced in a controlled manner by
      reducing the concentration of oxygen the participant breathes. The accuracy of a noninvasive
      pulse oximeter sensor will be assessed by comparison to the oxygen saturation measurements
      from a laboratory blood gas analyzer.

      It is required that the Accuracy Root Mean Square (ARMS) performance of the Stryker pulse
      oximetry sensors will meet a specification of +/-3% or better in non-motion conditions for
      the range of 70 - 100% SaO2 (typically, saturation is determined once with air breathing and
      then at one of 6 levels, e.g. 94%, 90%, 85%, 80%, 75% and 70% saturation for about 30-60
      seconds at each level), thereby demonstrating an acceptable SpO2 accuracy performance
      specification.
    

Intervention name(s): STRYKER SUSTAINABILITY SOLUTIONS PULSE OXIMETERS
Intervention type(s): Device
Intervention description(s): Reprocessed noninvasive pulse oximeters
1859 & 2329
MAX-A & MAX-N
Intervention model: Single Group Assignment
Intervention model description: Participants will be in a reclined position for the study. Reference sensors will be placed on each participant to evaluate the SpO2 accuracy and performance. Sensors may be placed on non-adjacent fingers to prevent optical crosstalk. Simultaneous data collection will be set up for devices under test. The data from the test devices will be collected by the sponsor or trained UCSF staff. Data will be collected for 1-2 second intervals data analysis. The SpO2 accuracy of the test devices will be evaluated over the oxygen saturation range between 70-100%.
Masking: None (Open Label)
Primary purpose: Other
Pilot of Mpowerment for Young Men Who Have Sex With Men (YMSM) in Beirut
Condition: HIV
Study type: Interventional

Summary: 
      This project will adapt and pilot a multi-level, community-based intervention to promote HIV
      prevention and sexual health among young men who have sex with men in Beirut.
    

Detailed description: 
      Mpowerment (MP) is an evidence-based community-level, structural, social and behavioral
      intervention for HIV prevention developed for YMSM that targets individual and community
      empowerment and mobilization, self-affirmation, sexual self-knowledge, and creation of a
      supportive social environment. MP has been widely used in the U.S., but not in a mostly
      Muslim setting. This project will adapt and pilot MP for the sociocultural issues facing YMSM
      (age 18-29) in Beirut. There will be a 2-year pilot implementation of MP, with longitudinal
      cohorts of YMSM in Beirut and Jounieh, the latter being the control community. Primary
      outcomes will be unprotected anal sex and HIV testing, with secondary outcomes being
      engagement in peer outreach, and perceived peer norms related to condom use and HIV testing.
    

Intervention name(s): Mpowerment
Intervention type(s): Behavioral
Intervention description(s): MP is a multi-level intervention that reaches out to all YMSM in a community by mobilizing men to encourage their friends to reduce risk behavior and join the program (informal outreach), along with holding social activities that promote safe sex (formal outreach). MP provides YMSM with skills, support and confidence to find solutions within themselves for sexual health, and seeks to affirm the validity and rights of same-sex behavior and identities.
Intervention model: Single Group Assignment
Intervention model description: Intervention will be evaluated with community cohort and use of pre- post-intervention analysis plan
Masking: None (Open Label)
Primary purpose: Prevention