bioihbjkbjnl/mcl2 huggingface dataset:
Critical Incident During Anaesthesia
Condition: Critical Incident; Safety Issues
Study type: Observational

Summary: 
      A multicenter study in Ukrainian hospitals on compliance with the requirements for responding
      to critical cases in the operating room, and the availability of relevant documentation and
      checklists.
    

Detailed description: 
      Timely information and response to emergencies are important both in the context of patient
      safety and in the context of the hospital economy. The availability of information systems is
      one of the security requirements of the Helsinki Declaration of Patient Safety.

      Ukraine has only just begun its path to implementing the Declaration of Helsinki in Ukrainian
      hospitals. The level of adherence to the recommendations can vary considerably depending on
      the region, the provision of the hospital and the effectiveness of the institution's internal
      management. In our survey of Ukrainian hospitals, only 74% of hospitals kept records of
      anaesthesia complications in general, with only 46% having separate electronic or paper
      documents to record complications; Also, the majority of respondent physicians (62.9%)
      reported the absence of checklists or algorithms for actions in case of emergencies or
      emergencies during anaesthesia.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Adult patients, who had critical incident during anesthesia.
      
Keywords: patient safety; critical incident; anaesthesia
Effect of Online Education Given to Young Adults on Testicular Cancer Health Beliefs and Behaviors
Condition: Testicular Neoplasms
MeSH terms: Testicular Neoplasms
Study type: Interventional

Summary: 
      Aim: One of the cheapest, easiest and most effective ways to detect testicular cancer early
      is to resort to early detection screening methods associated with health beliefs about
      testicular cancer, and the second is to self-examine the testicles. In the country, there are
      a limited number of studies on the health beliefs and early diagnosis behaviors of young
      adult men for testicular cancer. For this reason, the study was conducted to determine the
      effect of online education given to young adults on testicular cancer health beliefs and
      behavior.

      Material and method: The research was conducted as a randomized controlled experimental
      study. The study population consisted of 768 individuals who applied to Family Health Centers
      affiliated to Agri Provincial Health Directorate between April 2021 and June 2022, and the
      sample of the research consisted of 90 individuals selected from the population using the
      improbable random sampling method. "Descriptive Feature Form", "Champion's Health Belief
      Model Scale in Testicular Cancer Screenings" were used to collect data. In the analysis of
      data; percentile distribution, chi-square, Fisher-Freeman-Halton Exact test, t-test in
      independent groups, Repeated Measures ANOVA Test, Friedman Test, One Way ANOVA test, Kruskall
      Wallis test, and post hoc analyzes (Bonferroni, Games Howell, Dunn) were used.
    


Intervention name(s): Testicular Model BSE/TSE Training Set
Intervention type(s): Diagnostic Test
Intervention description(s): The investigators will use the Testicular Model BSE/TSE Trainer to transform individuals' routine testicular self-examination into behavior.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: In the study, 90 individuals, including 1 experimental and 1 control group, were included in the study.
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Health Belief Model; Health Behavior; Education, Distance; Testicular Neoplasms
Comparison of the Efficacy and Safety of Clindamycin + Benzoyl Peroxide Formulation With Azelaic Acid Formulation in the Treatment of Acne Vulgaris
Condition: Acne Vulgaris
MeSH terms: Acne Vulgaris
Study type: Interventional
Phase: Phase 4

Summary: 
      This is a randomized, comparator-controlled, single-blind, parallel-group study. The current
      study proposes to compare a fixed-dose combination product containing 3% benzoyl peroxide
      (BPO) and 1% clindamycin against a cream containing 20% azelaic acid for the treatment of
      facial acne vulgaris. The results of the study will enable a better assessment of the safety
      and efficacy of the new dose regime (BPO 3% + clindamycin 1%) in comparison to a well
      established treatment. Based on the data more evidence based recommendations will be possible
      to improve the treatment of subjects with acne vulgaris. A total of 220 subjects will be
      enrolled and will have 5 study visits (Day 1, Weeks 2, 4, 8 and 12). The duration of the
      study will be over 12 weeks.
    


Intervention name(s): Clindamycin + BPO; Azelaic acid
Intervention type(s): Drug; Drug
Intervention description(s): Gel containing 1.2% clindamycin and 3% BPO for once daily application; Cream containing 20% azelaic acid for twice daily application
Intervention MeSH terms: Clindamycin; Clindamycin palmitate; Clindamycin phosphate; Azelaic acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: azelaic acid; Clindamycin; Benzoyl peroxide; Acne vulgaris
The Impact of Two-field or Three-field Lymphadenectomy on Overall Survival in Middle and Lower Thoracic Esophageal Squamous Cell Carcinoma: An Observational Study
Condition: Esophageal Cancer
MeSH terms: Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma
Study type: Observational

Summary: 
      To clarify the effect of Two-field or Three-field Lymphadenectomy on the survival of
      esophageal squamous cell carcinoma.
    


Intervention name(s): Since the data were collected retrospectively, there were no interventions
Intervention type(s): Diagnostic Test
Intervention description(s): Since the data were collected retrospectively, there were no interventions
Observational model: Other
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with esophageal cancer and need surgical treatment.
The Effect of Fish Oil Supplementation on Endothelial Function, Heart Rate Variability and Intimal Media Thickness of Patients With Coronary Artery Disease
Condition: Coronary Artery Disease
MeSH terms: Coronary Artery Disease; Myocardial Ischemia; Coronary Disease
Study type: Interventional

Summary: 
      The purpose of this study is to investigate whether there is a difference in endothelial
      function, heart rate variability and carotid intimal media thickness in patients with
      coronary artery disease who are receiving fish oil therapy.

      One hundred patients with established coronary artery disease by coronary angiography will
      undergo randomization for enrollment in the study. Baseline evaluation will include
      assessment of brachial artery endothelial function, heart rate variability and carotid
      intimal media thickness. Evaluation of the endothelial function of the brachial artery will
      be elucidated by inflation of a blood pressure cuff around the arm for five minutes and
      measuring blood vessel dynamics after release of the cuff. Heart rate variability will be
      evaluated by 24 hour holter monitoring and analysis by standard protocol. Carotid intimal
      media thickness will be evaluated by ultrasound measurements guided by predetermined
      protocol. Patients will then be randomized to a highly purified fish oil, Omacor, 1 gram
      twice a day or placebo. Brachial artery ultrasound and holter monitoring will be repeated at
      2 months. Carotid ultrasound will be repeated at the end of the study at 12 months.
    


Intervention name(s): Omacor (omega-3-acid ethyl esters)
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: prospective, placebo-controlled, randomized, double-blind trial
Masking: Double
Primary purpose: Treatment
Keywords: omacor; fish oil; omega 3; fatty acids; coronary artery disease; endothelial function; heart rate variability; carotid intimal media thickness; QT dispersion
Vestibular Evoked Myogenic Potential: A New Device Propose
Condition: Evoked Potentials, Motor, Vestibular
Study type: Observational

Summary: 
      The bioelectrical responses of muscle, evoked by sound, obtained with a device considered the
      gold standard (widely used in clinics and hospitals) are similar to those obtained with a new
      device developed
    


Intervention name(s): Vestibular myogenic evoked potential analyzer
Intervention type(s): Device
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Adults, Normal Hearing, Normal Vestibular fuction,
Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia
Condition: Postoperative Cognitive Dysfunction
MeSH terms: Postoperative Cognitive Complications; Cognitive Dysfunction
Study type: Interventional
Phase: Phase 4

Summary: 
      As the investigators know, postoperative cognitive dysfunction (POCD) is a fairly
      well-documented clinical phenomenon, which affect patients' short-term and long-term outcome.
      Most patients will receive general anesthesia and cardiopulmonary bypass (CPB) during cardiac
      valvular surgery. Inhalation sevoflurane based and propofol based anesthesia are most
      commonly used strategy for general anesthesia. At present, it was unknown that which one is
      better in providing cerebral protection effect for patients undergoing cardiac valvular
      surgery with CPB. The current study aimed to explore the possible difference.
    

Detailed description: 
      The investigators hypothesize that the incidence of postoperative cognitive dysfunction
      (POCD) is not different in patients received intravenous anesthetics propofol or sevoflurane
      for their cardiac valvular surgery. Two groups of general anesthetics (propofol or
      sevoflurane) are used to explore the possible difference of the postoperative outcome and the
      incidence of POCD. After cardiac valvular surgery with CPB, patients' POCD tests at 7 days
      after the surgery, and postoperative delirium, etc., are evaluated by different
      questionnaires. Also the blood sample of these patients are collected for detection of some
      stress hormones.
    

Intervention name(s): sevoflurane; propofol
Intervention type(s): Drug; Drug
Intervention MeSH terms: Propofol; Sevoflurane
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Sevoflurane; Propofol; Cardiac valvular surgery; Cardiopulmonary bypass; Postoperative cognitive dysfunction
A Phase I Study for Safety and Tolerability of AL002.
Condition: Healthy; Alzheimer Disease
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a multi-centre, randomized, double-blind, placebo-controlled, dose escalation first
      in human (FIH) study in healthy adults and in patients with mild to moderate Alzheimer's
      disease. The study is designed to systematically assess the safety (including immunogenicity)
      and tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of AL002.
    

Detailed description: 
      The study will be conducted in 2 phases:

      In the single ascending dose (SAD) phase up to approximately 56 healthy adult participants
      will be sequentially enrolled into up to approximately 9 cohorts In the multiple-dose (MD)
      phase, approximately 32 patients with mild to moderate Alzheimer's disease will be enrolled
      in three cohorts.
    

Intervention name(s): AL002; Saline Solution
Intervention type(s): Biological; Other
Intervention description(s): Single-doses of AL002 in up to 9 dose-escalating cohorts; Saline solution will be administered as a single infusion for each cohort in a ratio of 6 active and 2 placebo subjects for HV and 10 active and 2 placebo for patients
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
A Clinical Trial for the Treatment of Depression With Repetitive Transcranial Magnetic Stimulation (rTMS)
Condition: Depressive Disorder, Major
MeSH terms: Depression; Depressive Disorder; Depressive Disorder, Major
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether the Cervel Neurotech rTMS device is safe
      and effective in the treatment of depression in people who do not get better with
      antidepressant medications or cannot take antidepressant medications.
    


Intervention name(s): Active Cervel Neurotech Multi-Coil Transcranial Magnetic Stimulator; Inactive Cervel Neurotech Multi-Coil Transcranial Magnetic Stimulator
Intervention type(s): Device; Device
Intervention description(s): The Cervel Neurotech multi-coil transcranial magnetic stimulator is an investigational repetitive transcranial stimulation (rTMS) device. In the active group, magnetic power output will be delivered to the subject through the coils.; The Cervel Neurotech multi-coil transcranial magnetic stimulator is an investigational repetitive transcranial stimulation (rTMS) device. In the inactive group, no magnetic power output will be delivered to the subject through the coils.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Depression; Depressive Disorder; Major depression; Major depressive disorder; MDD; Treatment resistant depression; Treatment intolerant depression; TRMD; TIMD; Transcranial Magnetic Stimulation; TMS
Efficacy of PRF and MTA as Compared to Calcium Hydroxide for Pulpotomy in Human Irreversibly Inflamed Permanent Teeth
Condition: Pulpitis - Irreversible; Tooth Decay
MeSH terms: Pulpitis
Study type: Interventional
Phase: Phase 2

Summary: 
      Of all the various pulpotomy medicaments that have been studied till to date, three agents
      have been selected for this study to compare their efficacy. CH being the control, MTA being
      one of the most recommended biomaterial and PRF that in addition to being a biomaterial is an
      autologous agent. Uptil now there have been no prospective trials using these three pulpotomy
      agents in mature permanent teeth with irreversible pulpitis in our part of the world and even
      the international studies that have been done utilized different methodologies with no
      unanimous conclusion. This is the reason that at present this treatment regime (pulpotomy)
      showing better perspectives cannot be presented with confidence as a predictable treatment
      option to the patients with irreversible pulpitis. By virtue of this study this challenge is
      being undertaken.

      Hypothesis:

      ALTERNATE HYPOTHESIS There is a difference between the efficacy of the PRF, MTA and CH when
      used as pulpotomy medicaments in mature permanent teeth with irreversible pulpitis NULL
      HPOTHESIS There is no difference in efficacy of the PRF, MTA and CH when used as pulpotomy
      medicaments in mature permanent teeth with irreversible pulpitis
    


Intervention name(s): Calcium hydroxide; MTA; PRF
Intervention type(s): Other; Other; Other
Intervention description(s): Calcium hydroxide in the power/liquid form will be used and placed on the exposed pulp; Mineral trioxide aggregate will be used as a powder / liquid form and placed over the exposed pulp; PRF will be placed directly over the exposed pulp
Intervention MeSH terms: Calcium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: MTA; Calcium Hydroxide; PRF; Pulpotomy; Irreversible pulpitis; Permanent teeth; Medicament
Mindfulness for Physical Activity Research Project
Condition: Physical Activity
Study type: Interventional

Summary: 
      This study aims to evaluate the feasibility and preliminary effectiveness of a Mindfulness
      for Physical Activity programme on physical activity outcomes in underactive participants.
    

Detailed description: 
      In recent years, mindfulness-based approaches have increasingly been used in mental and
      physical health interventions. There appears to be some consensus about the benefits of
      standard mindfulness courses, such as Mindfulness-Based Stress Reduction and
      Mindfulness-Based Cognitive Therapy on stress, anxiety and depression, and other health
      conditions. In terms of physical activity, however, evidence for the use of mindfulness
      training to promote and improve physical activity is scarce and shows conflicting results.
      Evidence suggests that mindfulness training may enhance psychological factors related to
      exercise, such as intrinsic motivation to engage in physical activity, tolerance of physical
      activity-related discomfort, and physical activity self-regulation, which could potentially
      enhance physical activity maintenance in the long run.
    

Intervention name(s): Mindfulness for Physical Activity
Intervention type(s): Behavioral
Intervention description(s): The Mindfulness for Physical Activity (MfPA) programme aims to change participants' relationship with physical activity by targeting psychological factors related to physical activity uptake and maintenance.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Mindfulness
Myofascial Release of Physiological Chains and Muscle Stretching in Patients With Fibromyalgia
Condition: Fibromyalgia
MeSH terms: Fibromyalgia; Myofascial Pain Syndromes
Study type: Interventional

Summary: 
      Muscle stretching is a therapeutic technique commonly used by physiotherapists, but for the
      treatment of fibromyalgia it still has weak evidence to support its real effect. On the other
      hand, myofascial mobilization in the location of tender points, as it is the solution for the
      population, demonstrating effects on the improvement of the symptoms, but not yet achieving
      the minimal clinically important change. In this context, myofascial release guided by
      physiological chains, so far not studied, is presented as an alternative to improve pain and
      quality of life in patients with fibromyalgia because it acts in a global way and, probably,
      more effective.

      This study evaluates the effect of myofascial release of the trunk physiological chains and
      muscle stretching on pain, quality of life and functional capacity of patients with
      fibromyalgia when compared to the control group.
    


Intervention name(s): Myofascial release; Muscle stretching; Control
Intervention type(s): Other; Other; Other
Intervention description(s): Manual therapy; Muscle stretching; Medical appointment
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants will be allocated in 3 groups. The myofascial release group, muscle stretching group and control group.
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Myofascial release; Pain; Manual therapy; Muscle stretching; Quality of life
Clinical Trial of Intravitreal Injection of Autologous Bone Marrow Stem Cells in Patients With Retinitis Pigmentosa
Condition: Retinitis Pigmentosa
MeSH terms: Retinitis; Retinitis Pigmentosa
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the safety of intravitreal injection of autologous
      bone marrow stem cells in patients with retinitis pigmentosa by a prospective, single-center,
      randomized, parallel, double-blind, phase I placebo-controlled clinical trial.
    


Intervention name(s): Intravitreal injection of Autologous bone marrow Stem Cell; Subconjunctival injection of saline
Intervention type(s): Biological; Other
Intervention description(s): We will proceed to the injection of 0.1 ml of the suspension with the autologous MNC of BM avoiding coincide with conjunctival and scleral hole and perpendicular to the sclera.
After the injection, a dry, sterile dressing will be placed to prevent reflux. Immediately, the perception of light, the movement of the central retinal artery, the venous pulse and the color of the papilla will be evaluated. If necessary, anterior chamber paracentesis will be performed.
After injection, the patient will remain with closed eyes and sitting, waiting for cells will be deposited on the bottom of the eyeball and for 3 days will instill tropicamide collyrium every 12 hours.; In the control eye, will make a subconjunctival injection of 0.1 ml saline. To realize contralateral injection gloves and all surgical materials will change, trying extreme measures of sterility.
After injection, the patient will remain with closed eyes and sitting, waiting for cells will be deposited on the bottom of the eyeball and for 3 days will instill tropicamide collyrium every 12 hours.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Clinical and Radiographic Evaluation of Turmeric, Thymus Vulgaris, Nigella Sativa and Aloe Vera as Pulpotomy Medicaments in Primary Teeth
Condition: Pulpitis - Irreversible
MeSH terms: Pulpitis
Study type: Interventional

Summary: 
      when caries reaches the pulp of the tooth, it has to be removed and replaced with a material.
      In this study im examining the clinical and radiographic signs and symptoms after using
      different natural materials in pulpotomized molars and compared to the formocresol.
    

Detailed description: 
      Patients who have irreversible pulpitis and need pulpotomy will be selected randomly from the
      out patient clinic. they will be assigned randomly to different study and control groups.
      pulpotomy will be performed in the second primary molar and 1 of the five materials will be
      put in the pulp chamber (aloe vera, nigella sativa, thymus vulgaris, turmeric and
      formocresol). It will be covered with a restoration and a stainless steel crown. Patients
      follow up will be done after 1,3,6 and 12 months to assess clinical and radiographic signs
      and symptoms.
    

Intervention name(s): Pulpotomy
Intervention type(s): Procedure
Intervention description(s): Irreversibly damaged dental pulp is partially removed and a dressing either Turmeric or Thymus Vulgaris or Nigella Sativa or Aloe Vera is placed. Clinical and Radiographic signs and symptoms are assessed and compared with Formocresol.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment