Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors
Condition: Thymoma
MeSH terms: Thymoma
Study type: Interventional

Summary: 
      the World Health Organization (WHO) has proposed a classification of histopathological thymic
      tumor and it significance in prognosis. Chest computed tomography (CT) is the most common
      method to evaluate thymic epithelial tumors before operation. Therefore, the question is to
      predict the histopathological type of thymic epithelial tumors before surgery based on
      CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no
      published literature on this issue.
    

Detailed description: 
      1. Introduction: the World Health Organization (WHO) has proposed a classification of
           histopathological thymic tumor and it significance in prognosis. Chest computed
           tomography (CT) is the most common method to evaluate thymic epithelial tumors before
           operation. Therefore, the question is to predict the histopathological type of thymic
           epithelial tumors before surgery based on CT-scan images , to help determine treatment
           strategy and prognosis. In Vietnam, there are no published literature on this issue.

        2. Materials and methods:

           2.1. Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT
           and had postoperative histopathology results as thymic epithelial tumors

           2.2. Time and Place: in Departement of CTVS, Military Hospital 103, Vietnam from 10/2013
           to 7/2017.

           2.3. methods:

             -  study in chest CT scan:

                  -  Measure the maximun diameter of the tumor

                  -  The contour: smooth contour or irregular contour

                  -  The shape: round, oval and plaque base on the ratio between long axis and
                     short axis of the tumor

                  -  Some other characteristics: Degree of enhancement, Level of drug absorbed,
                     Calcification, Invasion the local organs and Capsular destruction.

             -  Histopathological study: based on the 2004 WHO classification:

                  -  Thymoma: type A, AB, B1, B2, B3

                  -  Thymic carcinoma

             -  Data processing: use software Epi Info 2000.

        3. Expectation of results

             -  Relationship between the size and histopathological type of thymic epithelial
                tumors.

             -  Comparison of some characteristics of the tumor on preoperative chest CT scans and
                histopathological type of thymic epithelial tumors
    

Intervention name(s): CT and histopathological classification
Intervention type(s): Other
Intervention description(s): Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors. Base on the characteristics in Chest CT scan in each postoperative histopathology results.
Intervention model: Single Group Assignment
Intervention model description: Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Computed tomography; thymic epithelial tumors