bioihbjkbjnl/mcl2 huggingface dataset:
10-week Yoga Practice Effect on Cognitive and Motor Function in Older Adults
Condition: Aging; Healthy Aging
Study type: Interventional

Summary: 
      Thirty-three healthy elderly people, who were classified into two age groups, participated in
      this study. All participants had not practiced yoga before and were asked not to perform any
      sports activities while the research was ongoing. In the experimental group, participants (n
      = 18) had to participate in 10 weeks of yoga classes. In the control group, participants (n =
      15) did not perform any exercises or other changes in their daily living life.

      Experimental measurements: Brunel, PSS-14 and HAD questionnaires
    


Intervention name(s): Yoga trainings
Intervention type(s): Other
Intervention description(s): 10-week yoga sessions, 2 times per week, 90 min per session.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Mechanisms of Endothelial Dysfunction in Type 2 Diabetes
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      Endothelial dysfunction of conduit arteries plays an important role in the development of
      cardiovascular complications associated with type 2 diabetes. In order to propose targeted
      therapeutic approaches, this study aim to determine the mechanisms involved in endothelial
      dysfunction of conduit arteries in these patients.
    


Intervention name(s): Blood samples
Intervention type(s): Biological
Intervention description(s): Blood samples will be performed at baseline and during endothelial stimulation by hand skin heating to quantify metabolites of NO, EETs, ET-1 and ROS
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Copenhagen Head Injury Ciclosporin (CHIC) Study
Condition: Traumatic Brain Injury
MeSH terms: Brain Injuries; Brain Injuries, Traumatic; Wounds and Injuries
Study type: Interventional
Phase: Phase 2

Summary: 
      This is an open label study on the pharmacokinetics and safety of ciclosporin in patients
      with severe traumatic brain injury, who require intensive care unit admission and monitoring
      of intracranial pressure via a ventricular catheter. 20 patients will be screened, and
      subsequently enrolled after clinical stabilisation. Thereafter, patients will receive 2.5
      mg/kg bolus dose infusion of ciclosporin, followed by either 5 mg/kg/day or 10 mg/kg/day of
      ciclosporin as continuous infusion for 5 days+3 days monitoring at the intensive care unit.
      After an additional 30 days, a follow-up phone call will be made to the patient, or the
      patient's nursing staff, checking patient status and serious adverse events. The two dose
      levels will be investigated in 10 patients each, starting with the lower dose level for the
      first 10 patients. Patients will have samples of blood and cerebrospinal fluid drawn at
      pre-defined time points during the study for pharmacokinetic assessment and evaluation of
      biomarkers. Bedside monitoring with microdialysis and brain tissue oxygenation will be
      performed. The safety monitoring includes nephrotoxicity, hepatotoxicity, monitoring of
      intracranial pressure (ICP), infections monitoring and adverse events collection and
      reporting.
    


Intervention name(s): NeuroSTAT 5 mg/kg/day; NeuroSTAT 10 mg/kg/day
Intervention type(s): Drug; Drug
Intervention description(s): Intravenous bolus of NeuroSTAT (Ciclosporin) 2.5 mg/kg bodyweight followed by 5 days of 5 mg/kg bodyweight/day continuous infusion; Intravenous bolus of NeuroSTAT (Ciclosporin) 2.5 mg/kg bodyweight followed by 5 days of 10 mg/kg bodyweight/day continuous infusion
Other intervention name(s): Ciclosporin 5 mg/kg/day; Ciclosporin 10 mg/kg/day
Intervention MeSH terms: Cyclosporine; Cyclosporins
Allocation: Non-Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Traumatic Brain Injury; TBI; ciclosporin; pharmacokinetic; safety; microdialysis; mitochondrial protection
Recruit Blood Donors Via SMS During Epidemic of COVID-19
Condition: Blood Donation
Study type: Interventional

Summary: 
      The fight against the spread of the 2019-nCoV epidemic has achieved some success in China,
      but the epidemic is far from over. A key factor making the epidemic under control in China is
      the government's call for social distance, which has led to few people going out for
      donation. As a result, the number of blood donors on the streets has been continuing to
      decline. Urgent recruitment of blood donors is therefore planned during the period from 30
      April to 10 May via emergency recruitment SMS . This study has been designed to compare which
      information extraction frameworks would be more sensitive to blood donors in emergency
      situations.
    

Detailed description: 
      Researches has showed that that the information extraction and processing in emergency was
      different from the normal situation. To understand what information the blood donors are more
      sensitive to in an environment that may pose a potential threat to themselves, this
      interventional study has been designed. Eligible blood donors in Guangzhou Blood Center has
      been randomly divided into four groups according to their sociological variables, their
      interval since last blood donation , their history donation times and the location of their
      last blood donation. Three groups of donors has been randomly selected as interventional
      groups, and will receive three kindly of emergency blood donor recruitment SMS respectively.
      The placebo group donors will only receive a May Day greeting SMS.

      One blood donor recruitment SMS will emphasize what blood services will do to ensure the
      safety of blood donors during their donation in 2019-nCoV epidemic, one will shows
      information about a loss-based framework, while the third one will show information about a
      benefit-based framework .
    

Intervention name(s): blood donation SMS
Intervention type(s): Behavioral
Intervention description(s): The literature shows that the information extraction and processing in emergency is different from the normal situation. To find the most effective emergency recruitment method during an outbreak, we intervened with a well-balanced group of donors by presenting different emergency recruitment text messages.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Computerized Intervention for Distress Intolerance
Condition: Cannabis Use Disorder
Study type: Interventional

Summary: 
      This study evaluates the impact of a computerized distress intolerance intervention relative
      to a control intervention on cannabis use-related behavior and neurophysiology.
    

Detailed description: 
      Distress intolerant cannabis users were randomized to a computerized distress intolerance
      intervention or a control intervention. Primary and secondary outcomes consist of the
      treatment target, cannabis use-related behavior, and theoretically-relevant
      neurophysiological processes (i.e., cannabis cue reactivity, response inhibition).
    

Intervention name(s): Computerized Distress Intolerance Intervention; Computerized Healthy Behaviors Intervention
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: At the end of the baseline assessment, the participant was randomized to the Computerized Distress Intolerance Intervention condition or the Computerized Healthy Behaviors condition. Participants in each condition attended two 1-hour intervention sessions followed by a post-treatment assessment. Follow-up assessments were conducted one-month and four-months after the post-treatment assessment.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: distress intolerance; stress
The Cognitive Effects of Lorazepam in Healthy Older Individuals With TOMM40 Variable-length Polymorphisms
Condition: Alzheimer's Disease (AD)
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      The investigators' goal is to determine if certain tests of memory and attention, performed
      while sleepiness is induced by a single dose of lorazepam, can predict whether or not an
      individual is at risk for developing Alzheimer's disease.
    


Intervention name(s): lorazepam
Intervention type(s): Drug
Intervention description(s): single dose of 1 mg lorazepam
Other intervention name(s): Ativan
Intervention MeSH terms: Lorazepam
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Alzheimer's disease (AD)
Clinical Trial of Tahitian Noni Juice Safety
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      For 28 days, healthy volunteers will consume one of four daily quantities of Tahitian Noni
      juice: 0 mL (placebo), 30 mL, 300 mL, or 750 mL. Hematology, biochemistry, urinalysis, vital
      signs, and adverse events measurements will be made at 0 (baseline), 2, and 4 weeks, as well
      as during a two-week follow up (week 6). Electrocardiogram (ECG) measurements will also be
      made for each volunteer during the pre-study screen and at week 6.
    


Intervention name(s): Tahitian Noni Juice; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): noni fruit juice; Placebo juice
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Keywords: Noni juice; Safety
Evaluation of Bone Metabolism Biomarkers in Periodontal Diseases
Condition: Periodontal Diseases
MeSH terms: Periodontal Diseases
Study type: Interventional

Summary: 
      This study evaluates the levels of biomarkers associated with bone metabolism in patients
      with different periodontal conditions.
    

Detailed description: 
      Background: In this study, the levels of bone metabolism markers found in the saliva of
      individuals with different periodontal conditions were compared and the relationship of these
      markers with periodontal status was examined.

      Method: A total of 60 individuals, 20 with periodontitis (P), 20 with gingivitis (G), and 20
      with periodontal healthy (S), were included in the study. Periodontal clinical parameters
      (plaque index, gingival index, bleeding on probing, clinical attachment level and probing
      pocket depth) and saliva samples were obtained from the individuals. Bone metabolism
      biomarker (necrotizing factor (TNF)-α, osteoprotegerin (OPG), nuclear factor kappa-β receptor
      activator ligand (RANKL) and sclerostin) levels in saliva samples were evaluated by
      enzyme-linked immunosorbent assay (ELISA).
    

Intervention name(s): ELISA
Intervention type(s): Diagnostic Test
Intervention description(s): ELISA(enzyme-linked immunosorbent assay)
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: periodontitis; saliva; sclerostin
Evaluating Motivation and Reward Mechanisms and Brain Substrates in Adults With Obesity
Condition: Anhedonia; Obesity
MeSH terms: Anhedonia; Obesity
Study type: Observational

Summary: 
      Anhedonia and abnormalities in reward behavior are core features of overweight/obesity (OW),
      a highly prevalent condition within MDD populations, and is independently associated with
      reward disturbances. The investigators therefore aim to investigate the brain substrates
      subserving reward and motivation in adults with overweight/obesity.

      The primary aim of this pilot study is to determine whether associations exist between
      obesity and decreased performance on the respective motivation/reward paradigms.
    

Detailed description: 
      Herein, the investigators are primarily interested in three overlapping, yet distinct
      aspects, of anhedonia. The investigators are primarily interested in motivation, reward
      valuation, and reward learning towards addressing the measurement of each of these respective
      subdomains, eligible participants will complete validated gold standard measures (i.e. the
      Effort Expenditure for Rewards Task (EEfRT) (reward valuation), Probabilistic Reward Task
      (PRT) (reward learning), and the Monetary Incentive Delay (MID) task (reward anticipation)).

      Twenty adults with overweight/obesity will complete all tasks at a single visit with two of
      the tasks being completed prior to MRI and one of the tasks (i.e. EEfRT) will be completed
      during MRI acquisition.

      The primary aim of this pilot study is to determine whether associations exist between
      obesity and decreased performance on the respective motivation/reward paradigms. In addition,
      associations between performance on reward tasks and functional connectivity, as measured by
      MRI and DTI, a secondary objective is to ascertain whether associations exist between
      performance on the motivation reward tasks and gold standard measures of food intake (i.e.
      food diary) and energy expenditure (i.e. calorimetry).
    

Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Participants will be identified at the Brain and Cognition Discovery Foundation (BCDF).
        Twenty subjects between the ages of 18-65 years with obesity, will be enrolled. All
        patients will be assessed for concurrent psychiatric disorders (e.g. mood disorders) and
        will meet DSM-V criteria for either: major depressive disorder (symptomatic or asymptomatic
        in any phase of the illness) or bipolar disorder I/II (symptomatic or asymptomatic in any
        phase of the illness).
Sub Urethral Sling With or With Out Anterior Repair
Condition: Urinary Incontinence
MeSH terms: Urinary Incontinence
Study type: Observational

Summary: 
      There is a concern about choosing adequate surgical options for stress urinary incontinence
      associated with vaginal prolapsed and still lack of evidence can be observed. In this study
      we compared primary and secondary outcomes of single or combine surgery for SUI with pelvic
      organ prolapsed.
    


Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        woman with stress urinary incontinence
Continuous Positive Airway Pressure (CPAP) Mode Impact on Clinical Blood Arterial Pressure
Condition: Obstructive Sleep Apnea Syndrome
MeSH terms: Sleep Apnea Syndromes; Sleep Apnea, Obstructive
Study type: Interventional

Summary: 
      Background: Continuous positive airway pressure (CPAP) is the first line therapy for
      obstructive sleep apnea syndrome (OSAS). Two positive airway pressure (PAP) modalities can be
      used: Fixed pressure, in which the effective pressure is set and kept constant all night, and
      auto CPAP devices where the positive pressure changes during the night depend on patient's
      requirements.

      Hypothesis: Pressure variations associated with autoCPAP functioning can lead to sleep
      fragmentation and alterations in sleep structure. This can limit blood pressure dipping
      during sleep and then impact clinical blood pressure reduction.

      Main objective: To compare in a randomized controlled trial 4 months clinical blood pressure
      (BP) evolution depending on CPAP mode: fixed pressure versus autoCPAP. Secondary outcomes:
      Evolution of arterial stiffness, biological parameters, quality of life and symptoms.

      Methods: Patients will be randomised depending on CPAP mode. Baseline and 4 months evaluation
      will include: 24-h ambulatory blood pressure monitoring, clinical BP measurements and
      carotid-to-femoral pulse wave velocity (PWV). Patients will also complete quality of life and
      symptoms questionnaires.

      2 interim analysis will be carried out when 150 and 220 patients respectively will have
      completed the study. The Peto's method will be used to correct the p-values.
    


Intervention name(s): S8 Spirit 2; Somnosmart 2; Remstar Auto
Intervention type(s): Device; Device; Device
Intervention description(s): 3 types of Continuous Positive Airway Pressure (CPAP) device: S8 Spirit 2, Somnosmart 2, Remstar Auto.
These 3 types of CPAP can be set in both mode of pressure.; 3 types of Continuous Positive Airway Pressure (CPAP) device: S8 Spirit 2, Somnosmart 2, Remstar Auto.
These 3 types of CPAP can be set in both mode of pressure.; 3 types of Continuous Positive Airway Pressure (CPAP) device: S8 Spirit 2, Somnosmart 2, Remstar Auto.
These 3 types of CPAP can be set in both mode of pressure.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: Obstructive Sleep Apnea Syndrome; Blood pressure; Continuous Positive Airway Pressure
Growth of Healthy Term Infants Fed Formula Containing DHA-B
Condition: Growth; Tolerance; Infant Development
Study type: Interventional

Summary: 
      The primary objective is to determine if the weight gain of healthy term infants fed a
      commercially available term infant formula supplemented with DHASCO® is similar to that of
      infants fed the same formula supplemented with a new product, DHASCO®-B.
    


Intervention name(s): infant formula with DHASCO; infant formula with DHASCO-B
Intervention type(s): Other; Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Wellbeing, Stress Reduction and Social Cognition
Condition: Cognitive Function 1, Social
Study type: Interventional

Summary: 
      There are many ways to improve wellbeing. This study will compare two 8-week wellbeing
      training programs. In addition to looking at how well the programs reduce stress and enhance
      wellbeing, the investigators will also ask questions about how these programs influence
      cognition and decision making.
    

Detailed description: 
      The training programs that aim to reduce stress and enhance wellbeing differ in terms of the
      techniques they utilize, as well as in terms of their mechanisms of change. These different
      mechanisms may have different impact on cognition and decision making. The aim of the study
      is to compare the different programs and also explore potential mediators of changes in
      wellbeing.
    

Intervention name(s): Active Comparator: Program 1; Active Comparator: Program 2
Intervention type(s): Behavioral; Behavioral
Intervention description(s): A well-established behavioral method for reducing stress. To maintain blinding, details will be given to participants after randomization.; A well-established behavioral method for reducing stress. To maintain blinding, details will be given to participants after randomization.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Classic and Sham Massage on Psychological and Physical Functional Variables in Athletes
Condition: Hamstring Contractures
MeSH terms: Contracture
Study type: Interventional

Summary: 
      In this study we intend to apply a treatment protocol for hamstrings that can be beneficial
      for a good recovery.

      Initially, a sample of athletes with hamstring shortening was chosen. Once the sample is
      chosen, it will be divided into two groups: group 1 (G.1) who will receives a sham massage,
      group 2 (G.2) that receives the classic massage.

      To finalize the study comparing the results of the two groups to observe the experimental
      protocol obtains better results.

      Material and methods The sample of an athletic club. Recruiting subjects between 18 and 45
      years old without other injuries of the lower limb. Subjects with shortening of the hamstring
      muscles are available through the specific shortening test.

      This is a randomized controlled trial. Subjects were randomly assigned to two intervention
      groups (1 treatment and 1 placebo control). The intervention consists of 4 sessions for 1
      month. The sessions have a duration of 45 minutes. Evaluations are performed at the beginning
      of treatment, at the end of treatment. Participants also perform strengthening exercises
      three days a week, a total of 3 sets with 15 repetitions each.

      Group 1 receives a sham massage of the quadriceps and hamstrings. Group 2 receives a classic
      massage of the quadriceps and hamstrings. The assessments consist of knee and hip goniometry,
      lumbar and hamstring flexibility by finger-to-floor testing, and complete the questionnaire
      Mood Status Profile (POMS), Which evaluates the states of mind.
    


Intervention name(s): Classic massage; Sham massage
Intervention type(s): Other; Other
Intervention description(s): It involves applying the classic massage techniques: effleurage (gliding or sliding movement over the skin with a smooth continuous motion following the direction of the muscle fibers of the superficial muscles in a distal to proximal direction); petrissage (lifting, wringing, or squeezing of soft tissues in a kneading motion, or pressing or rolling of the tissues under or between the hands); tapotement (various parts of the hand striking the tissues at a fairly rapid rate). The general objective is to improve extensibility of muscle, tendon, fascia, joint capsule, and ligamentous structures.; This group received a placebo intervention at the same time as the other group, maintaining only soft touch with the participant without exerting any mechanical pressure.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment