Cardio-pulmonary and Analgesic Effects of Pre-peritoneal VS Epidural Infusion of L-bupivacaine on Abd. Cancer Patients
Condition: Abdominal Cancer
MeSH terms: Abdominal Neoplasms
Study type: Interventional

Summary: 
      60 Patients will be randomly assigned using computer generated randomization program
      (http://www.randomizer.org) into two groups, First group (Control group ,Group of continous
      epidural infusion [CEI]), where patients will receive continuous epidural infusion of
      L-bupivacaine 0.125 % at a rate of .1 ml/kg/h during the first 48 hours after surgery. Second
      group (Group of continous preperitoneal infusion [CPI]), where patients will receive
      continuous pre-peritoneal wound infusion with L-bupivacaine 0.25% at 10 ml/h during the first
      48 hours after surgery.
    

Detailed description: 
      All patients will receive IV morphine when needed for a period of 48 hours with a PCA device
      programmed to deliver 1 mg/dose with a 10-minute lockout time without background infusion.

      CEI group The epidural catheter will be placed via a paramedian approach as close as possible
      to the surgical procedure via the inter-vertebral space (from T7 to T10) so that the affected
      dermatomes of the surgical wound would receive the benefits of bupivacaine infusion. Proper
      placement of the catheter was verified through an aspiration test and a test dose (2 ml) of
      lidocaine 2%. At the end of surgery, a 14 ml bolus of L-bupivacaine 0.125 will be
      administered through the catheter and then a continuous rate of .1 ml/kg/h infusion of
      L-bupivacaine 0.125 will be delivered.

      CPI group At the end of surgery and after the closure of the peritoneal layer, the catheter
      will be allocated above the peritoneum within the musculofascial layer and secured to the
      skin with an occlusive dressing. Thereafter, a 20 ml bolus of L-bupivacaine 0.25% will be
      administered through the catheter and then a continuous fixed-rate infusion of L-bupivacaine
      0.25% will be delivered.

      Outcome Measures The primary outcome will be the pulmonary effects including

      . Respiratory mechanics: Forced Vital Capacity (FVC) &Forced Expiratory Volume in one second
      (FEV1) will be assessed preoperatively and at 12h, 24h and 48 hours postoperatively.

      The Secondary outcome of the study will include the following:

        -  Cardiac enzymes: Troponin I and plasma BNP levels will be measured preoperatively and
           postoperative day 1 and day 2.

        -  Intensity of pain at rest and during pain-provoking movements (deep breathing, coughing,
           mobilization) measured by VAS pain score immediately postoperative then at 2, 4 ,6 ,12,
           24 ,36 &48 hours after surgery.

        -  Hemodynamic variables including (systolic and diastolic BP, heart rate, oxygen
           saturation & respiratory rate) measured preoperatively (baseline measurement) then
           immediately postoperative and at 2, 4 ,6 ,12, 24 ,36 &48 hours after surgery.

        -  Blood gases will be drawn preoperatively and at 12 hour interval in the PACU for
           assessment of Oxygen tension (PO2) & Co2 tension (PCO2).

             -  Morphine titration and dosage required in the post-anesthesia care unit (PACU).

             -  IV PCA Total morphine consumption during first 48 hours postoperatively.

        -  Time of return of intestinal sounds.

        -  CVP will be measured preoperatively and at post anaesthesia care unit for crude
           assessment of cardiac function

             -  Quality of night sleep assessed at 8:00 am on postoperative days 1 and 2 using a
                verbal numerical scale (VNS) ranging from 0 (poor quality) to 10 (excellent
                quality).

             -  Patient satisfaction with the quality of postoperative analgesia 48 hours after the
                end of surgery, assessed on a 5-point scale (completely dissatisfied, dissatisfied,
                not satisfied nor dissatisified, satisfied or completely satisfied [34].

             -  side effects, including hemodynamic variables (hypotension & bradycardia), supine
                hypotension ,shivering ,bladder distension and PONV.

        -  Complications of Thoracic epidural as (Inadvertent intrathecal injection, Spinal
           hematoma, Spinal abscess, superficial cellulites, PDPH, Nerve injury &Back pain) will be
           assessed and managed
    

Intervention name(s): levo-bupivacaine infusion via Thoracic epidural catheter; levo-bupivacaine infusion via preperitoneal catheter
Intervention type(s): Procedure; Procedure
Intervention description(s): The epidural catheter will be placed via a paramedian approach as close as possible to the surgical procedure via the inter-vertebral space (from T7 to T10) so that the affected dermatomes of the surgical wound would receive the benefits of bupivacaine infusion; At the end of surgery and after the closure of the peritoneal layer, the catheter will be allocated above the peritoneum within the musculofascial layer and secured to the skin with an occlusive dressing
Other intervention name(s): TEA
Intervention MeSH terms: Bupivacaine; Levobupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment