The Relation Between Placental Volume at the 1st Trimester and Perinatal Prognosis
Condition: Pregnancy Complications; Perinatal Problems; Maternal-Fetal Relations
MeSH terms: Pregnancy Complications
Study type: Observational

Summary: 
      It has been known for years that placental transport and endocrine and metabolic functions of
      the placenta are the main determinants of fetal nutrition and homeostasis. And placental
      capacity is roughly related to the weight of this organ. It has long been understood that
      placental weight at birth is also positively associated with birth weight. Since the 1970s,
      it has been possible to assess the size of the placenta in early pregnancy using
      two-dimensional (2D) ultrasonography (USG). Since then, it has been estimated that placental
      size is associated with fetal development. However, the difficulty in defining the required
      sonographic planes due to the technology of that time-limited the usefulness of this
      technique. As studies on this subject increase with the development of technology, it has now
      been shown that low placental volume at 11-13 weeks is associated with babies small for
      gestational age (SGA), fetal growth restriction, and preeclampsia. Pregnancy complications
      place a severe burden on the health system. Detection of these complications in the early
      period will prevent maternal and fetal mortality and morbidity. A relationship that predicts
      obstetric, fetal, and perinatal risks with placental thickness and width measurement with
      USG, a non-invasive method, in an early period such as the 1st trimester, will enable a
      proactive approach to complications. In our study, the investigators plan to present the
      perinatal results they obtained rather than investigating a specific relationship. The
      investigators think that the results of their study will make a profound contribution to the
      literature.
    

Detailed description: 
      This study aims to determine the relationship between the calculated placental volume in the
      1st trimester and poor perinatal outcomes. For this purpose, approximately 360 pregnant
      women, who were followed up in Siirt Training and Research Hospital between June 2022 and
      June 2023 and were in their first trimester of pregnancy, will be included in the study. The
      pregnant woman's age, pregnancy history, and medical history will be recorded. The patient's
      gestational week, placental volume, and location will be recorded during the examination. All
      participants will be followed up until delivery. During delivery, gestational week, delivery
      type, fetal weight, APGAR score, baby gender, and pregnancy outcomes, preeclampsia,
      Gestational Diabetes, Gestational Hypertensive diseases, Premature rupture of membranes,
      preterm labor, oligohydramnios, polyhydramnios, presentation anomaly, Intrauterine death,
      Perinatal fetal disorders such as distress, intrauterine growth retardation, preeclampsia,
      placental abruption, placental invasion anomaly, placental implantation anomalies,
      postmaturity will be recorded. In the light of the information gathered, the relationship
      between placental volume in the 1st trimester and perinatal prognosis will be determined.
    

Intervention name(s): Ultrasonographic examination
Intervention type(s): Other
Intervention description(s): Measurement of placental volume at the first trimester of pregnancy by using ultrasound.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Pregnant women over the age of 18 and at 11-14 weeks of pregnancy
      
Keywords: placental volume; perinatal prognosis; first trimester; pregnancy