bioihbjkbjnl/mcl2 huggingface dataset:
The Feasibility of a Brief Attention Training Technique in Improving Behaviour and Attention in Children With ADHD
Condition: Attention Deficit Hyperactivity Disorder
MeSH terms: Attention Deficit Disorder with Hyperactivity
Study type: Interventional

Summary: 
      This study aims to investigate the application of the Attention Training Technique in
      children with ADHD aged 7-11 years old. The research aims to investigate both the feasibility
      of this technique in this population as well as whether it can improve symptoms, behaviour
      and executive functioning.
    

Detailed description: 
      Attention deficit hyperactivity disorder (ADHD) is a neurobehavioural disorder characterised
      by core symptoms of hyperactivity, impulsivity and inattention. Its prevalence ranges between
      3-9% of school-aged children, making it one of the most common presentations in child and
      adolescent mental health services.

      In the last 10 years, research into the effectiveness of attention training as an
      intervention for children with ADHD has been increasing. This has tended to follow
      assumptions that children with the disorder either lack skills in focusing and maintaining
      their attention and/or have neurological deficits in areas responsible for attention
      functions. Results have been encouraging, with study participants demonstrating improvements
      in symptoms and behaviour following a course of attention training. However, the method and
      length of training has varied across studies.

      This study aims to investigate a treatment called the Attention Training Technique (ATT) that
      approaches attention difficulties in this disorder from a different perspective. Instead of
      viewing inattention as a result of structural or skills deficits, it posits that children
      with ADHD have these skills, but are perhaps unaware of the flexibility and control they have
      over them. This treatment aims to increase this awareness and subsequently improve ratings of
      attention, behaviour and other areas of executive functioning.
    

Intervention name(s): Attention Training Technique
Intervention type(s): Behavioral
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Pharmacokinetics and Pharmacodynamics Clinical Study of VC005 Tablets in Healthy Subjects
Condition: Inflammatory Bowel Diseases
MeSH terms: Inflammatory Bowel Diseases
Study type: Interventional
Phase: Phase 1

Summary: 
      This clinical trial consists of two parts：1. a randomized, double-blind, single-center,
      placebo-controlled, dose-escalation PK study; 2. food effects and drug metabolism
      transformation study.

      The main purpose of this trial is to evaluate the Safety, Tolerance, Pharmacokinetics,
      Pharmacodynamics and Food effects of VC005 Tablets in healthy subjects.
    


Intervention name(s): VC005 Tablets; VC005 Tablets Placebo; VC005 Tablets food effects group
Intervention type(s): Drug; Drug; Drug
Intervention description(s): VC005 Tablets 1、5、10、25、50、100mg single dose; VC005 Tablets Placebo 1、5、10、25、50、100mg single dose; VC005 Tablets qd per period, for two periods
Allocation: Randomized
Intervention model: Sequential Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: healthy subjects
Pharmacokinetics of DMF and the Effects of DMF on Exploratory Biomarkers
Condition: Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Sclerosis
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to explore whether DMF (Dimethyl Fumarate) or MMF (monomethyl
      fumarate) its main bioactive metabolite, is capable of entering the central nervous system in
      SPMS patients that are being treated with Tecfidera®. PK samples (pharmacokinetics - or the
      amount of study drug in blood) will be tested to compare with PK samples, the amount of study
      drug, in spinal fluid (CSF).
    


Intervention name(s): BG00012 (DMF) (Tecfidera®.)
Intervention type(s): Drug
Intervention description(s): Subjects will take DMF 120 mg BID for the first 4 weeks of treatment followed by DMF 240 mg BID for 24 weeks.
Intervention MeSH terms: Dimethyl Fumarate
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Neuromuscular Balance in Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional
Phase: Phase 4

Summary: 
      The research was an interventional study with a quantitative board, fulfilled in a private
      clinique specialized in trauma service; it was formed between august to October of 2006. The
      objective was to investigate the effectiveness of neuromuscular balance in lumbar pain. The
      12 patients, with age between 20 and 55 years, whose did five consultations, with 100%
      presence, got relief of the pain and increase of movement of hips' articulation which was the
      most painful movement with 91,66% graduation. All the patients presented the shorting test
      positive and it kept positive in 7 patients. There was a significant improvement in pain
      relief (p=0,001,) comparing the first and the fifth consultation, and hip articulation
      movement. Even after the relief of the pain, 7(58,3%) of the patients kept the treatment for
      a more effective rehabilitation and prevention of repetition of the symptoms. It was
      concluded that the neuromuscular balance relieved quickly the pain, being essential for
      effective rehabilitation of low back pain, with the inclusion of others manual techniques.
    

Detailed description: 
      The low back pain is a symptom presented in muscle-skeletal change on lumbar region,
      preferring young adults, in economic active fase. The neuromuscular balance was developed by
      Soulier when he met the "activator methods" which was a pen that create vibrations and
      consist in a vibration or a micro thrust to reduce the articulation and spinal problems
      through a non manipulative correction. The research was un interventional study with a
      quantitative board, fulfilled in a private clinique specialized in trauma service; it was
      formed between august to October of 2006. The objective was to investigate the effectiveness
      of neuromuscular balance in lumbar pain. The 12 patients, with age between 20 and 55 years,
      whose did five consultations, with 100% presence, got relief of the pain and increase of
      movement of hips' articulation which was the most painful movement with 91,66% graduation.
      All the patients presented the shorting test positive and it kept positive in 7 patients.
      There was a significant improvement in pain relief (p=0,001,) comparing the first and the
      fifth consultation, and hip articulation movement. Even after the relief of the pain,
      7(58,3%) of the patients kept the treatment for a more effective rehabilitation and
      prevention of repetition of the symptoms. It was concluded that the neuromuscular balance
      relieved quickly the pain, being essential for effective rehabilitation of low back pain,
      with the inclusion of others manual techniques.
    

Intervention name(s): Neuromuscular balance
Intervention type(s): Other
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Low back pain; physical therapy; pain
Effects of Music on Table Tennis Stroke Performance Among Mentally Fatigued University Players
Condition: Mental Fatigue
MeSH terms: Mental Fatigue
Study type: Interventional

Summary: 
      The current study is going to investigate the music intervention on the table tennis stroke
      performance among table tennis stroke performance. The subjects will be instructed to listen
      to 3 minutes, which can facilitate the recovering process for scope of attention and
      thought-action repertoire. Thus, to see the improvement in stroke performance.
    

Detailed description: 
      The intervention of this study is music, specifically, instruct subjects to listen inducing
      positive emotion music due to positive emotion benefit to cognition performance.

      The condition of mental fatigue will be induced by Stroop task. Before the intervention or
      process of listening music, the pre-test will be recorded to compare the post-test value of
      table tennis stroke performance.

      Moreover, the different music intervention will be implemented to identify the optimal
      selection.
    

Intervention name(s): Inducing positive emotion music
Intervention type(s): Other
Intervention description(s): listening to music could induce emotion response, this study is going to investigate inducing positive emotion music countering mental fatigue.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Improving Access to Care: Testing an Integrated Care Mobile Health Intervention
Condition: Insomnia; Delayed Sleep Phase
Study type: Interventional

Summary: 
      This study aims to evaluate the feasibility, effectiveness, and dissemination potential of an
      innovative strategy for improving access to effective sleep health care for adolescents. The
      study will test an adaptation of the Transdiagnostic Sleep and Circadian Intervention
      (TranS-C), a brief sleep intervention with demonstrated efficacy for improving sleep and
      mental health outcomes in youth.
    

Detailed description: 
      This adaptation is designed to address the following key challenges to accessing care: (1) to
      overcome the challenge of low availability of qualified providers as a barrier to treatment
      access, we have adapted TranS-C for online and mobile device delivery (referred to as
      mTranS-C), thereby leveraging the high rates of mobile phone and internet use in adolescents;
      (2) to further increase access we will disseminate mTranS-C within primary care services, a
      proven strategy for improving access to behavioral health care; and (3) we focus on
      low-income communities, where there is a higher prevalence of sleep problems and low access
      to services.
    

Intervention name(s): mTranS-C
Intervention type(s): Behavioral
Intervention description(s): mobile health
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Clinical Pharmacological Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure)
Condition: Cardiac Edema
MeSH terms: Heart Failure; Edema, Cardiac; Edema
Study type: Interventional
Phase: Phase 3

Summary: 
      To investigate the pharmacokinetics, pharmacodynamics (urine volume and fluid intake),
      efficacy(body weight, pulmonary congestion and other congestions including cardiothoracic
      ratio) and safety of 7-day repeated oral administration of OPC-41061 at 7.5 mg or 15 mg in
      congestive heart failure (cardiac edema) patients with extracellular volume expansion despite
      the use of a diuretic.
    


Intervention name(s): OPC-41061(Tolvaptan); Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Subjects will be orally administered OPC-41061 7.5 mg or 15 mg once daily after breakfast for seven days.; Subjects will be orally administered placebo once daily after breakfast for seven days.
Intervention MeSH terms: Tolvaptan
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Vasopressin antagonist; Cardiac Edema; Diuretics
Indirect Ultrasonographic Findings for Parametrial Involvement in Deep Endometriosis
Condition: Endometriosis; Deep Endometriosis
MeSH terms: Endometriosis
Study type: Observational

Summary: 
      This study evaluated the use of ultrasonographic findings as a first-line imaging tool to
      raise indirect suspicion of parametrial involvement in women suspected of having severe
      endometriosis (DE).
    

Detailed description: 
      Ultrasonographic findings will be conventionally divided in:

        -  concomitant DE nodules

        -  indirect DE signs
    

Intervention name(s): Ultrasound
Intervention type(s): Diagnostic Test
Intervention description(s): Preoperative transvaginal/transabdominal ultrasonography done according to IDEA criteria.
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with suspected deep endometriosis undergoing surgical approach in a third-level
        referral center for endometriosis between January 2021 and December 2021
      
Keywords: Parametrial endometriosis; Deep endometriosis; Transvaginal Ultrasound
Vaccine Treatment for Ebola Virus in Healthy Adults (V920-001)
Condition: Ebola Virus
MeSH terms: Hemorrhagic Fever, Ebola
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a study of the anti-Ebola vaccine vesicular stomatitis virus (VSV) ZEBOV (Zaire
      ebolavirus) also known as V920 and BPSC-1001. The purpose of this study is to test how safe
      the vaccine is in humans and how well it makes the human immune system cause an immune- or
      defense-response to Ebola virus. This vaccine will be studied at different doses.
    

Detailed description: 
      This study is being conducted to assess whether this vaccine is safe, and if it causes the
      body to create an infection-fighting response. Between 1994 and the present, there have been
      many Ebola virus outbreaks caused by 4 different strains of the virus, affecting mostly
      people living in central Africa and the health care providers trying to treat them. Ebola
      viruses are members of the filoviridae virus family, which also includes the dangerous
      Marburg virus. Ebola virus causes severe and often deadly infection called a viral
      hemorrhagic fever, characterized by organ failure, bleeding, and death.

      To date, the virus is found primarily in Central and West Africa. It is not clear where these
      viruses come from, but it is thought that bats are the most likely source of the human
      outbreaks that occur. Once an outbreak occurs, the virus is spread from person to person
      through direct contact with infected blood or body fluids with an infected individual.

      Given the recent increase in Ebola virus infections occurring in Africa, there is interest in
      making an effective vaccine to protect against the infection. V920/BPSC-1001 is an
      experimental Ebola vaccine candidate demonstrating protection against Ebola virus in animal
      experiments.

      This is a Phase 1 study to evaluate a novel vaccine to Ebola using a live VSV replacing the
      gene encoding the G envelope glycoprotein with the gene encoding the envelope glycoprotein
      from the Zaire strain of Ebola (VSVΔG-ZEBOV also known as V920 and BPSC-1001). This phase 1
      protocol provides a first-in-human study to evaluate the safety and toxicity of
      V920/BPSC-1001 in healthy adult participants. Participants will be randomized to receive
      V920/BPSC-1001 or Placebo by intramuscular injection. Three dose levels will be assessed with
      follow-up visits through 180 days after the injection.
    

Intervention name(s): V920; Placebo
Intervention type(s): Biological; Other
Intervention description(s): Vesicular Stomatitis Virus (VSV)-based vaccine 1-mL injection containing 3x10^6, 2x10^7, or 1x10^8 pfu.; Normal saline placebo.
Other intervention name(s): BPSC-1001
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Prevention
Virtual Reality Exposure Therapy in Agoraphobic Participants
Condition: Panic Disorder; Agoraphobia
MeSH terms: Panic Disorder; Agoraphobia
Study type: Interventional

Summary: 
      Virtual Reality Exposure Therapy (VRET) is an effective treatment for anxiety disorders,
      particularly for specific phobias as fear of heights and fear of flying (e.g. Powers &
      Emmelkamp, 2008). Recent technological advances (e.g. more realistic avatars) make research
      into the efficacy of VRET for participants with elevated agoraphobic symptoms desirable.
      Therefore, the aim of the present research proposal is to investigate the comparative
      efficacy of:

        1. enhanced VRET making use of the latest avatar technology with

        2. exposure in vivo in agoraphobic participants

        3. wait-list control.
    


Intervention name(s): Virtual Reality Exposure Therapy for agoraphobic participants; Standard exposure in vivo for agoraphobic participants
Intervention type(s): Behavioral; Behavioral
Intervention description(s): This intervention is comprised of 10 sessions of cognitive behavior therapy for panic disorder and agoraphobia with components of
Psycho-education, breathing training and cognitive restructuring
Virtual reality Exposure to agoraphobic situations and interoceptive exposure
Relapse prevention; This intervention is comprised of 10 sessions of cognitive behavior therapy for panic disorder and agoraphobia with components of
Psycho-education, breathing training and cognitive restructuring
Standard exposure in vivo to agoraphobic situations and interoceptive exposure
Relapse prevention (according to the protocol of Craske & Barlow)
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Panic Disorder and Agoraphobia; Virtual Reality Exposure Therapy
A Trial to Assess Diets Containing Beef vs. Poultry on Pancreatic Beta-Cell Function
Condition: PreDiabetes
MeSH terms: Prediabetic State; Glucose Intolerance
Study type: Interventional

Summary: 
      The objective of this study is to assess and compare the effects of usual diets containing
      lean beef vs. lean poultry on pancreatic beta-cell responses in men and women with
      prediabetes.
    


Intervention name(s): Beef; Poultry
Intervention type(s): Other; Other
Intervention description(s): Beef entrees; Poultry entrees
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
Masitinib in Primary Progressive Multiple Sclerosis or Relapse-free Secondary Progressive Multiple Sclerosis
Condition: Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Sclerosis; Recurrence
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate the activity of oral AB1010, administered at two
      dose levels during 3 years to patients with primary or secondary progressive multiple
      sclerosis.
    


Intervention name(s): masitinib; masitinib
Intervention type(s): Drug; Drug
Intervention description(s): masitinib 3 mg/kg/day; masitinib 6 mg/kg/day
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: primary progressive multiple sclerosis; relapse-free secondary progressive multiple sclerosis
The Pain and Anxiety in Children With Intramuscular Injection
Condition: Intramuscular Myxoma
MeSH terms: Myxoma
Study type: Interventional

Summary: 
      This study was planned as a randomized controlled experimental study to determine the effect
      of distraction cards and stress ball on pain and anxiety in children with intramuscular
      injection.
    

Detailed description: 
      Pharmacological and non-pharmacological methods are used in the management of pain and
      anxiety in children. Non-pharmacological methods are noninvasive, inexpensive, have no side
      effects and are independent functions of the nurse.This study was planned as a randomized
      controlled experimental study to determine the effect of distraction cards and stress ball on
      pain and anxiety in children with intramuscular injection. The study was conducted between
      May 2022 and August 2022. It will be done with children aged 3-6 years who come to the
      emergency unit of the State Hospital, who are given intramuscular injection.

      "Descriptive Information Form", "Wong Baker Faces Pain Rating Scale", "Venham Anxiety Rating
      Picture Scale" will be used in data collection.
    

Intervention name(s): Distraction Card; Stress Ball
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Suitable for children over 3 years old. 1 set of 32 pieces of thick cardboard cards It has been prepared by child development experts in line with pedagogical principles.
Size: 13cm x 8cm, Each card illustrates the skills and actions the children do.; Brain Shaped Stress Ball, White rope in the form of mesh around the inner silicone Size: Approx 2.4 inches (6 cm), Color: Colorful, When squeezed, the silicone structure comes out in the mesh spaces and turns into a bunch of grapes.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Children; Pain, Acute; Anxiety
Two Different Exercise Training in Frozen Shoulder Treatment
Condition: Adhesive Capsulitis
MeSH terms: Bursitis
Study type: Interventional

Summary: 
      The aim of this study is to compare the effects of two different exercise programs in
      patients with frozen shoulders.
    

Detailed description: 
      After being informed about the study, all patients giving written informed and meet the
      inclusion criteria will be randomized a double-blind manner in a 1:1 (participant and
      investigator) to graded motor imagery or exercise group.
    

Intervention name(s): Graded Motor Imagery; Exercise
Intervention type(s): Other; Other
Intervention description(s): Graded Motor Imagery program will be performed two times a week for six consecutive weeks and will include the following three steps: laterality training, imagined movements, and mirror therapy.
Right-left discrimination training (lateralization training)
Imagination of hand movements (motor imagery):
Mirror therapy Treatments including traditional physiotherapy approaches; joint mobilizations, stretching, scapula focused exercises etc.; Treatments including traditional physiotherapy approaches; joint mobilizations, stretching, scapula focused exercises etc.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: frozen shoulder; exercise; graded motor imagery