Targeting Aging and Promoting Longevity With Exogenous Nucleotides (TALENTs)
Condition: Aging
Study type: Interventional

Summary: 
      To investigate the effects of dietary nucleotides (NTs) as an anti-aging supplement, a
      clinical trial is carried as a randomized, double-blind, parallel design, placebo-controlled.
      A total of 120 subjects will be enrolled in the study, and they shall be randomly distributed
      between the two arms, NTs-treated, and placebo-control. They would be given several
      measurements, including physical examination, questionnaire survey, clinical and
      aging-related biomarkers tests at 0 (baseline), 2, and 4 months during the RCT.
    

Detailed description: 
      To explore the anti-aging effects of NTs and the regulation of aging-related diseases, this
      study plans to recruit 120 people as subjects and conduct randomized controlled trials with
      NTs as an intervention for 4 months. Based on computer-generated random numbers, participants
      who meet the inclusion criteria are randomly assigned equally to two groups: placebo control
      and nucleotide intervention groups. In this study, the specific nucleotide composition is
      5'-AMP、5'-CMP、5'-GMPNa2、5'-UMPNa2 prepared according to the ratio of 16:41:19:24, which is
      consistent with the ratio in breast milk and meets the requirements of national infant
      formula addition and special medical food formula. The dose of 1.2 g/day used is currently
      approved as the ingredient dose of nucleotides in conventional commercially available health
      food products. At the 0、2 and 4 months of the study, comprehensive geriatric health
      assessment, aging biomarker testing and biological sample collection will be conducted. Among
      them, the comprehensive evaluation of elderly health status is carried out by physical
      examination and questionnaire survey, including physical health, physiological function,
      quality of life, cognitive function, psychosocial health, and other aspects of information.
      The physical examination involves both physical assessment and functional assessment,
      including body composition, neck circumference, waist circumference, hip circumference,
      middle arm circumference, calf circumference, BMR, grip strength, six-minute walk,
      intima-media thickness, subcutaneous AGEs, and spirometry. The scale includes health status,
      nutritional status, cognitive status, physical activity, and dietary status. Blood samples
      were used to detect the safety and senescence-related indicators of the subjects. The index
      system covers four modules and seventeen dimensions, including blood routine, blood
      biochemistry, inflammatory factors, immune antibodies, T lymphocyte subtypes, oxidative
      stress level, cancer markers, leukocyte telomere length, DNA methylation, γ-H2A. Blood
      samples are sequenced simultaneously for gene and transcriptome sequencing. Fecal samples are
      collected for metagenomic sequencing of intestinal flora.
    

Intervention name(s): dietary nucleotides; placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 1.2 g/d NTs (5 '-AMP, 5' -CMP, 5 '-GMPNa2, 5' -UMPNa2) ;; placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: completely randomized design
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: anti-aging; telomerase