bioihbjkbjnl/mcl2 huggingface dataset:
Detection of Adenomas in Screening Colonoscopy
Condition: Adenoma Colon
MeSH terms: Adenoma
Study type: Interventional

Summary: 
      The Endocuff study aims to show an increase of the number of detected adenomas in screening
      colonoscopies when a endocuff vision (Arc Medical Design Ldt Leeds England) is used.
    

Detailed description: 
      Endocuff is a relatively new device which is intended to be attached to the end of the
      colonoscope. Several minor studies have shown that the use of Endocuff probably increases the
      number of detected polyps in colonoscopy. Endocuff is made of soft plastic and has been
      designed to give an optimal view of the entire colon. It gently averts and flattens folds in
      order to see small polyps "hiding" in the space behind colonic folds.

      The purpose of this study is to investigate into the effect of the Endocuff in screening
      colonoscopy compared with screening colonoscopy performed without Endocuff. The device has
      been used during several years yet an effect on the number of polyps detected during
      screenings colonoscopy has not been shown. This studies main hypothesis is that the use of
      Endocuff in screenings colonoscopy will increase the adenoma detection rate in these
      patients, with a potential to reduce interval cancer.

      This study is a randomized controlled trial with 900 patients.
    

Intervention name(s): endocuff; no endocuff
Intervention type(s): Device; Procedure
Intervention description(s): Endocuff is a relatively new device which is intended to be attached to the end of the colonoscope.; colonoscopy is performed without endocuff.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: this is a randomized controlled trial
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: adenoma detection rate; screening colonoscopy
GlowCaps Adherence Randomized Control Trial
Condition: Medical Adherence
Study type: Observational

Summary: 
      This randomized control trial will explore interventions to promote medication adherence
      using a novel electronic device that can track daily pill use. 500 subjects will be
      randomized into 4 arms of the experiment. In addition to a control arm, our three arms will
      be: reminders, financial incentives, and reminders and financial incentives.
    

Detailed description: 
      The investigators aim to study simple "behavioral economics" interventions that rely on
      consumer engagement to overcome cognitive and motivational barriers to medication adherence.
      Our goals are threefold: (1) to analyze which interventions are most effective in promoting
      medication adherence; (2) to analyze which interventions are most effective in promoting
      long-term habits that persist even when the interventions are removed; and (3) to understand
      how various patient characteristics (e.g. age or risk preferences) predict adherence or
      treatment receptivity. The investigators plan to track daily adherence of patients to a
      prescribed chronic disease drug using a new technology that electronically monitors when a
      pill bottle has been opened. In our control condition, patients will be monitored but not be
      provided with any reminders, adherence information, or incentive to adhere to their
      medication. Our three additional treatments will be either: (1) provide the patient with a
      daily email, text message, or phone call reminder to take the pill; (2) pay patients for each
      day that they take their pill (3) provide the patient with a daily email, text message, or
      phone call reminder to take the pill and pay patients for each day that they take their pill.
    

Intervention name(s): GlowCap; Daily email, text message, or phone call reminders; Paid for adherence
Intervention type(s): Device; Behavioral; Behavioral
Intervention description(s): The main research instrument is an electronic pill bottle called GlowCaps (by Vitality) that has the ability to transmit adherence data to the Way to Health (WTH) web portal. The investigators will measure adherence by counting the number of properly taken doses during the final four weeks of the study. Each time the pill bottle is opened, a date- and time-stamped wireless signal is sent to the Vitality server via the AT&T cellular network which will then be uploaded to the Way to Health portal for aggregation.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Adults aged 18 to 64, receiving coverage from Independence Blue Cross (IBX), and receiving
        an oral prescription for chronic disease. Subjects were recruited from a base pool of
        eligible subjects identified by IBX as patients who have been identified as having the
        lowest medication possession ratios.
SunSmart Intervention in Schools
Condition: Melanoma
MeSH terms: Melanoma
Study type: Interventional

Summary: 
      A prevention study to improve sun exposure behaviors in children after an educational
      classroom-based intervention.
    

Detailed description: 
      This study aims to demonstrate that learning about sun exposure using a more classroom-based
      intervention will motivate classroom students to reduce exposure at a critical life period
      and will create lifetime learned sun exposure behaviors. Students' sun exposure behaviors
      will be assessed prior to the educational intervention. The educational intervention consists
      of three educational sessions and one lab lesson. At the conclusion of the intervention,
      students' sun exposure behaviors will be assessed again via a post-intervention
      questionnaire.
    

Intervention name(s): Knowledge Assessment
Intervention type(s): Behavioral
Intervention description(s): Students participating in this study will receive a pre test, instruction regarding sun safety, and a post test.
Intervention model: Single Group Assignment
Intervention model description: All students who participate in this study will be given a pre test, instruction regarding sun exposure and a post test to determine their sun exposure behaviors and knowledge of sun exposure risks.
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Sunscreen; Sun Exposure; Behaviors; Baseline Assessments; Follow-up Assessments; Knowledge
To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of Inhaled AZD8683
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to assess the safety, tolerability, pharmacokinetics and
      pharmacodynamics of increasing single doses of AZD8683 administered via inhalation
    

Detailed description: 
      A Phase I, Single Centre, Double-blind, Randomised, Placebo-controlled, Parallel-group Study
      to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of inhaled AZD8683
      after Single Ascending Doses administered via Turbuhaler in Healthy Subjects
    

Intervention name(s): AZD8683; Placebo to match
Intervention type(s): Drug; Drug
Intervention description(s): Single Dose Inhaled IMP via Turbuhaler; Single dose Inhaled Placebo via Turbuhaler
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: Phase 1; healthy volunteers; safety; tolerability; pharmacokinetics; single ascending dose study
Dexamethasone and Wound Healing After Thyroid Surgery
Condition: Wound Infection
MeSH terms: Wound Infection
Study type: Interventional

Summary: 
      Dexamethasone is a potent glucocorticoid with analgesic and anti-emetic effects [1-3].
      Perioperative single-dose dexamethasone therapy has been used for several purposes: to reduce
      post-operative nausea and vomiting (PONV), pain and sore throat. There are also some reports
      on beneficial effects of less cardiac arrhythmia, improved appetite and less edema from
      glucocorticoids. Preoperative small dose of dexamethasone was reported to prevent reversal
      laryngeal nerve injury and improve voice quality after thyroid surgery. While accepted wildly
      in clinical anesthesia practice, the immune-press related potential risks of side effects
      associated with dexamethasone, such as delayed wound healing, infection, as well as effects
      on blood sugar, make the use of perioperative single dose of glucocorticoid controversial.
      The effect of perioperative dexamethasone on wound healing varied with different types of
      surgery. The present study will observe the effect of dexamethasone on the safety of thyroid
      surgery.
    

Detailed description: 
      Patients who has the thyroid surgery for their thyroid cancer will be randomly allocated into
      two groups, either dexamethasone group or saline group. In the dexamethasone group, patients
      will receive 5mg dexamethasone iv right after general anesthesia induction while in the
      saline group, patients will have 1ml saline iv. The drainage fluid will be collected at 6
      hours after surgery and on every morning after operation till the drainage tube is taken out.
      The total amount of drainage fluid and blood stain area in dressing will be collected and
      calculated after the operation. The C-reaction protein is checked in drainage fluid and in
      blood after operation. Besides, the pain scores of incision pain and throat pain will be
      evaluated. Postoperative nausea and vomit will be checked as well.
    

Intervention name(s): Dexamethasone; saline
Intervention type(s): Drug; Drug
Intervention description(s): dexamethasone 1ml (5mg); saline 1ml
Intervention MeSH terms: Dexamethasone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
F17464 in Acute Schizophrenia Trial
Condition: Schizophrenia
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate the potential efficacy of oral F17464 in comparison
      to placebo over 6 weeks in patients with acute exacerbation of schizophrenia. Study design:
      double-blind, randomized, placebo-controlled, parallel-groups, fixed-dose design, multicentre
      study.
    


Intervention name(s): F17464; Placebo
Intervention type(s): Drug; Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Schizophrenia; Mental disorders; Antipsychotic Drugs
Pain Relief Effect of Angiopuncture for Patients With Postoperative Pain
Condition: Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      The study aimed to investigate the effectiveness of angiopuncture therapy in pain alleviation
      for postoperative pain patients. The study involved patients aged 20-65 with acute foot and
      ankle trauma and pain after surgery. Physicians used handheld ultrasound Doppler to measure
      perforators, puncture participants with a filiform needle, and monitor pain scores and heart
      rate data before and after acupuncture. The duration of therapy was 20 minutes per day for 72
      hours, with pain measured using the numerical rating scale. The study aimed to compare the
      outcomes before and after angiopuncture.
    

Detailed description: 
      In order to give therapeutic therapy, solid filiform needles are inserted into the skin
      during dry needling (DN), traditional acupuncture (TA), and western medical acupuncture
      (WMA). DN is a treatment used to treat painful musculoskeletal illnesses, whereas TA and WMA
      have a wider variety of indications, including musculoskeletal discomfort, gastrointestinal
      problems, and neurological concerns. While DN implants are used in trigger points,
      acupuncture is for acupoints.

      In addition, common methods include injections of painkillers, oral medications, and nerve
      blocks. Angiopuncture therapy is being used for the first time as a method of pain management
      in this article. The aim was to investigate if skin perforating needling therapy could
      alleviate postoperative pain in patients.

      Patients with recent foot and ankle surgery who have had acute foot and ankle injuries and
      pain. Doctors measured three to four perforators at the proximal end of the trauma site using
      a handheld ultrasound Doppler, punctured the perforators for 15 minutes with a filiform
      needle (size: 0.18mm gauge * 25mm length), and then monitored the patient's pain level and
      heart rate data before and after acupuncture Variety. If pain relief is possible, they'll do
      it. Risks include becoming more painful.

      To create numbers, investigators employed an internet table generator. Despite having just
      one group, investigators compared the results of angiopuncture before and after therapy lasts
      for 20 minutes per day for 72 hours. Numeric rating scale (NRS) pain score at baseline: 6,
      12, 24, 36, 48, 60, and 72 hours.
    

Intervention name(s): angiopuncture
Intervention type(s): Behavioral
Intervention description(s): we conducted acupuncture on perforators by using acupuncture needles.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of Practical Demonstration to Use Nasal Spray and Apply Intranasal Ointment on Epistaxis
Condition: Epistaxis
MeSH terms: Epistaxis
Study type: Interventional

Summary: 
      To compare the result of verbally educating the parents about method of intranasal antiseptic
      cream application versus practically educating and demonstrating how to apply cream intra
      nasally.
    

Detailed description: 
      The primary outcome variables was control of epistaxis through history and clinical
      examination on follow up visits
    

Intervention name(s): Health education with practical demonstration of nasal ointment; Health Education and practical demonstration of Nasal spray and intranasal ointment
Intervention type(s): Procedure; Drug
Intervention description(s): Health education with practical demonstration of medicine was compared to health education without practical demonstration; We compared the effect of Health education and practical demonstration for using nasal spray and apply intranasal ointment compared to health education without practical demonstration
Other intervention name(s): Group A and B; Health education with practical demonstration group
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Epistaxis; Randomized control trial; Health education
A Study to Evaluate Rituximab in Combination With Methotrexate in Methotrexate-Naive Patients With Active Rheumatoid Arthritis
Condition: Rheumatoid Arthritis
MeSH terms: Arthritis; Arthritis, Rheumatoid
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a phase III, randomized, controlled, double-blind, parallel group, international
      study in approximately 750 patients with active Rheumatoid Arthritis (RA) who are naive to
      Methotrexate (MTX) therapy. Rheumatoid Factor (RF)-positive and RF-negative patients will be
      enrolled and will be allocated equally between 3 treatment arms.
    


Intervention name(s): folate; methotrexate; methylprednisolone; placebo; rituximab
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): Intravenous repeating dose; Oral or parenteral repeating dose; Intravenous repeating dose; Intravenous repeating dose; Intravenous repeating dose
Intervention MeSH terms: Methylprednisolone; Rituximab; Methotrexate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Rituxan; MTX; RA; IMAGE; WA17047
Atazavanir/Ritonavir-based HAART in Children
Condition: HIV
Study type: Interventional
Phase: Phase 2

Summary: 
      There are no data on efficacy, safety and pharmacokinetics of ATV/r-based HAART in
      HIV-infected Asian children. Therefore, the investigators aim to evaluate the
      pharmacokinetics, efficacy and safety of ATV/r-based HAART in Thai HIV-infected children.
    

Detailed description: 
      Non-nucleoside reverse transcriptase inhibitor (NNRTI)-based HAART have been commonly
      prescribed as the first-line HAART for HIV-infected children in resource-limited settings.
      Protease inhibitor (PI)-based HAART are the recommended second-line regimen after failing
      NNRTI-based HAART. The most commonly used PI in Thailand is lopinavir/ritonavir (LPV/r).
      However, the metabolic complications of lopinavir/ritonaive (LPV/r) such as hyperlipidemia
      and lipodyrtrophy are common and a concern for HIV-infected children as it may contribute to
      the development of cardiovascular disease in the longer term. There are data on efficacy,
      safety and pharmacokinetics of ATV/r-based HAART in HIV-infected adults but none in children.
      Furthermore, many studies in both adults and children have shown that different ethnicities
      can result in different pharmacokinetic response to antiretroviral drugs. As a result of
      this, this study investigated the efficacy, safety and pharmacokinetics of ATV/r-based HAART
      in HIV-infected Asian children.
    

Intervention name(s): boosted atazanavir (ATV/r)
Intervention type(s): Drug
Intervention description(s): ATV/r will be taken orally once daily with food plus standard dose of 2 NRTIs according to Thai National HIV treatment guideline
Intervention MeSH terms: Atazanavir Sulfate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: pharmacokinetics; atazanavir/ritonavir; HIV-infected children
Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Metformin and Digoxin in Healthy Subjects
Condition: Diabetes; Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This trial is conducted in Europe. The aim of this trial is to investigate the influence of
      oral semaglutide on pharmacokinetics (the exposure of the trial drug in the body) of
      metformin and digoxin in healthy subjects.
    


Intervention name(s): semaglutide; metformin; digoxin; placebo
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Oral administration of 5 mg daily for one week, then escalated to 10 mg daily for one week, followed by escalation to 20 mg daily for 41 days; Oral administration of 850 mg twice daily for 3 days followed by 850 mg on day 4, assessed in 3 dosing periods 1) alone, 2) co-administration with SNAC (sodium N-[8-(2-hydroxybenzoyl) amino] caprylate) and 3) co-administration with oral semaglutide.; Oral administration of 0.5 mg single dose, assessed in 3 dosing periods 1) alone, 2) co-administration with SNAC (sodium N-[8-(2-hydroxybenzoyl) amino] caprylate) and 3) co-administration with oral semaglutide.; Oral administration of SNAC 300 mg. Will be administered with the morning dose of metformin (1st, 3rd, 5th and 7th dose). On Day 24, a single SNAC dose will be administered with digoxin.
Intervention MeSH terms: Metformin; Digoxin
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Efficacy of Dextenza Insert in Upper vs Lower Punctum Following Cataract Surgery With PCIOL.
Condition: Cataract
MeSH terms: Cataract
Study type: Interventional
Phase: Phase 4

Summary: 
      To assess the safety and effectiveness of treatment with an intracanalicular dexamethasone
      (0.4mg) insert in the operating room following cataract surgery/intraocular lens implant
      (IOL) with or without iStent/Hydrus/Goniotomy when placed in the lower punctum compared to
      the upper punctum.
    

Detailed description: 
      This is a randomized, controlled study to evaluate the safety and effectiveness of treatment
      with an intracanalicular dexamethasone (0.4mg) insert in the operating room following
      cataract surgery/intraocular lens implant (IOL) with or without iStent/Hydrus/Goniotomy when
      placed in the lower punctum compared to the upper punctum.
    

Intervention name(s): Dextenza 0.4Mg Ophthalmic Insert
Intervention type(s): Drug
Intervention description(s): (dexamethasone ophthalmic insert)-for the treatment of ocular inflammation and pain following following ophthalmic surgery.
Intervention MeSH terms: Dexamethasone; Dexamethasone acetate; BB 1101
Allocation: Randomized
Intervention model: Sequential Assignment
Intervention model description: Each subject's participation is expected to last for approximately 1 month and will be required to complete six scheduled visits over the course of the study period: Baseline (Screening Visit), Operative Visit/Insertion Day (Day 0), Day 1, Day 8, Day 14 and Day 30.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: PCIOL; CCI CE
Modulation of Metabolic Rate by Inorganic Nitrate
Condition: Resting Metabolic Rate
Study type: Interventional

Summary: 
      The purpose of this study is to determine the effects of sodium nitrate on resting metabolic
      rate, glucose uptake and formation of reactive oxygen species in humans.
    


Intervention name(s): Glucose Uptake; Resting metabolic rate; Nitrite infusion
Intervention type(s): Other; Other; Other
Intervention description(s): Glucose uptake is measured by oral glucose tolerance test and euglycemic clamp; Resting metabolic rate is measured by indirect calorimetry after an over-night fast; Sodium nitrite or saline was infused at escalating doses at a rate of 1, 10 or 100 nmol kg-1 min-1 (10 minutes per dose) in a randomized, double blinded cross-over fashion
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: Nitrate; Nitrite; Nitric oxide; Resting metabolic rate; Glucose uptake; Insulin sensitivity; Reactive oxygen species production; inorganic nitrate; Sodium nitrite infusion