Formulas for Diabetes With Sucromalt & Isomaltulose on Glycemic Index, Hormones & Subjective Appetite in Type 2 Diabetes
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      Consumption of nutritional supplements with low glycemic carbohydrates induce favorable
      glycemic responses in subjects with type 2 diabetes. The aim of this study was to compare the
      effect of the intake of specific formulas for diabetes, with different types of carbohydrates
      (isomaltulose and sucromaltose) on the glycemic response, release of intestinal peptides and
      subjective appetite in Type 2 diabetic individuals. In a randomized, double-blind, cross-over
      study of 4 treatments, 16 subjects (56.60 ± 1.11 years). Fasting blood samples were taking,
      after that they were given to consume formula or reference product assigned randomly.
      Subsequently, samples of capillary and venous blood were obtained at times 30, 60, 90, 120
      and 180 min, after the start of consumption of the experimental beverage for the measurement
      of glucose, insulin, gastric inhibitory peptide (GIP) and glucagon-like peptide-1 (GLP-1).
      The assessment of subjective appetite was measured by Visual Analogue Scale (VAS).
    

Detailed description: 
      This was a randomized, double-blind, cross-over study of 4 treatments that was conducted
      according to the Good Clinical Practice Guidelines, with all applicable Food and Drug privacy
      regulations, and ethical principles based on the Declaration of Helsinki. Participants signed
      informed consent, approved by the Human Research Ethics Committee of the Endocrine-Metabolic
      Research Center of the University of Zulia, in Venezuela. All selected subjects attended a
      first visit, in order to determine if they met the inclusion criteria, those who gathered
      them, were subjected to four consumption tests to determine the glycemic index (GI) and
      glycemic load (GL) and 3 consumption tests for the evaluation of subjective appetite. Each
      treatment or consumption session was carried out on different days.
    

Intervention name(s): Ensure® Abbott Nutrition; Glucerna® Abbott Nutrition; Diasip® Nutricia Advanced; Glicolab®
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Effect of the intake of Ensure® Abbott Nutrition on the glycemic index, insulin, GLP-1, GIP levels and subjective appetite in subjects with type 2 diabetes; Effect of the intake of Glucerna® Abbott Nutrition on the glycemic index, insulin, GLP-1, GIP levels and subjective appetite in subjects with type 2 diabetes; Effect of the intake of Diasip® Nutricia Advanced on the glycemic index, insulin, GLP-1, GIP levels and subjective appetite in subjects with type 2 diabetes; Effect of the intake of Glicolab on the glycemic index, insulin and subjective appetite in subjects with type 2 diabetes
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Participants receive 4 nutritional formulas to evaluate their glycemic index, insulin, GLP-1, GIP levels and subjective appetite
Masking: Double (Participant, Care Provider)
Primary purpose: Basic Science
Keywords: Glycemic Index; Insulin; Incretins; Diabetes Mellitus type 2; Subjective appetite; Nutritional formula