To Compare the Pulpal Oxygen Saturation Level After Administering Mepivacaine With and Without Vasoconstrictor
Condition: LOCAL ANESTHESIA
Study type: Interventional
Phase: Phase 2

Summary: 
      As vasoconstrictors adversely affect pulpal hemodynamics, this study compared the pulpal
      oxygen saturation levels after employing inferior alveolar nerve block with 2% mepivacaine
      with 1:100,000 epinephrine (2% Scandonest Special) and 3% mepivacaine (3% Scandonest
      Plain).Two groups were made with 30 patients in each group. 2% mepivacaine with 1:100,000
      epinephrine (2% Scandonest Special) was administered to the patients in Group A whereas 3%
      mepivacaine (3% Scandonest Plain) was administered to the patients in Group B. Rubber dam
      application, cavity preparation and composite filling was then done on the selected carious
      mandibular premolar. Pulpal oxygen saturation levels were recorded after administration of
      local anesthesia with Nellcor-550 pulse oximeter and Nellcor D-YS Multisite reusable sensor.
    

Detailed description: 
      BACKGROUND ' Local anesthesia is the foremost requirement of an efficient operative dental
      procedure to be executed in a pain free and calm environment. Local anesthesia is available
      in two forms: with vasoconstrictor and without vasoconstrictor. As vasoconstrictors adversely
      affect pulpal hemodynamics, this study aims to compare the pulpal oxygen saturation levels
      after employing inferior alveolar nerve block with 2% mepivacaine with 1:100,000 epinephrine
      (2% Scandonest Special) and 3% mepivacaine (3% Scandonest Plain).

      NULL HYPOTHESIS There is no difference between the pulpal oxygen saturation levels after
      administering 2% mepivacaine with 1:100,000 epinephrine and 3% mepivacaine.

      ALTERNATE HYPOTHESIS There is a difference between the pulpal oxygen saturation levels after
      administering 2% mepivacaine with 1:100,000 epinephrine and 3% mepivacaine.

      METHOD Two groups were made with 30 patients in each group. 2% mepivacaine with 1:100,000
      epinephrine (2% Scandonest Special) was administered to the patients in Group A whereas 3%
      mepivacaine (3% Scandonest Plain) was administered to the patients in Group B. Rubber dam
      application, cavity preparation and composite filling was then done on the selected carious
      mandibular premolar. Pulpal oxygen saturation levels were recorded after administration of
      local anesthesia with the Nellcor- PM 10N pulse oximeter and Nellcor D-YS Multisite reusable
      sensor.

      STATISTICAL ANALYSIS The statistical package for social sciences version 21.0 is used for
      statistical analysis. Mean and standard deviation of the pulpal oxygen saturation levels for
      filled and unfilled teeth under the effect of 2% mepivacaine with 1:100,000 epinephrine and
      3% mepivacaine were recorded. Mixed Way ANOVA will be applied to discern if there is any
      difference in the pulpal oxygen saturation levels within and between the two groups. Post Hoc
      Tuckey was applied to identify whether the paired difference is present within groups or
      between the two groups.
    

Intervention name(s): 3% Mepivacaine Hydrochloride; 2% Mepivacaine with 1:100,000 epinephrine
Intervention type(s): Drug; Drug
Intervention description(s): 1.8 ml of 3% mepivacaine (3% Scandonest, Septodont) was administered to Group B patients. Inferior alveolar nerve block was administered to both the groups. Rubber dam was then placed in the desired quadrant. Selected carious mandibular was restored and seven pulpal oxygen saturation spot readings were taken for an hour.; 1.8 ml of 2% mepivacaine with 1:100,000 epinephrine (2% Scandonest Special, Septodont) was administered to Group A patients. Inferior alveolar nerve block was administered to both the groups. Rubber dam was then placed in the desired quadrant. Selected carious mandibular was restored and seven pulpal oxygen saturation spot readings were taken for an hour.
Other intervention name(s): 3% scandonest plain; 2% scandonest special
Intervention MeSH terms: Epinephrine; Mepivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Diagnostic
Keywords: pulpal oxygen saturation