Effect Of Intravenous Hyoscine -N-Butyl Bromide In Management Of Prolonged Labor In Nulliparous
Condition: Prolonged Labor
Study type: Interventional

Summary: 
      Women will be admitted when active phase of labour starts defined as the presence of at least
      three regular uterine contractions over 10 minutes with cervical dilatation four centimeters
      with cervical effacement not less than 50% and no progress of labor for 2 hours or more.

      Amniotomy was done in those with intact membrane and continuous electronic fetal monitoring
      was done. Women with prolonged labor after these measures were randomly divided using
      automated web-based randomization system into 2 equal groups. Group I included 50 women
      received 40mg HBB (Buscopan, Memphis Co, Giza, Egypt) intravenous bolus injection. Group II
      included 50 women received 2 ml of normal saline. The obstetrician, participants and outcome
      assessor were all blinded to the group assignment. Labor will be monitored by Vaginal
      examination every two hours. The duration of the first stage was calculated from the time of
      cervical dilatation of three to four centimeters in active labor until a fully dilated cervix
      was observed.
    

Detailed description: 
      Women will be admitted when active phase of labour starts defined as the presence of at least
      three regular uterine contractions over 10 minutes with cervical dilatation four centimeters
      with cervical effacement not less than 50% and no progress of labor for 2 hours or more.

      Amniotomy was done in those with intact membrane and continuous electronic fetal monitoring
      was done. Women with prolonged labor after these measures were randomly divided using
      automated web-based randomization system into 2 equal groups. Group I included 50 women
      received 40mg HBB (Buscopan, Memphis Co, Giza, Egypt) intravenous bolus injection. Group II
      included 50 women received 2 ml of normal saline. The obstetrician, participants and outcome
      assessor were all blinded to the group assignment. Labor will be monitored by Vaginal
      examination every two hours. The duration of the first stage was calculated from the time of
      cervical dilatation of three to four centimeters in active labor until a fully dilated cervix
      was observed.
    

Intervention name(s): Hyoscine N Butylbromide; Normal Saline 0.9%
Intervention type(s): Drug; Drug
Intervention description(s): 7. Group A will receive injection Hyoscine butyl bromide 40 mg single intravenous dose; Group B, will receive 2 ml of normal saline single intravenous dose
Other intervention name(s): Buscopan; Saline
Intervention MeSH terms: Scopolamine; Butylscopolammonium Bromide
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Group A will receive injection Hyoscine butyl bromide 20 mg first dose at the time of amniotomy, and second dose 2 hours after. Group B, will receive normal saline same volume first dose at the time of amniotomy, and second dose 2 hours after
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment