bioihbjkbjnl/mcl2 huggingface dataset:
Psychosocial and Physiological Mechanisms in the Effect of Hormonal Contraception on the Female Sexual Desire
Condition: Healthy
Study type: Interventional

Summary: 
      75 heterosexual women are asked to use 3 different types of contraception (Nuvaring, low-dose
      combination pill, minipill), each during 3 months. On a monthly basis, questionnaires are
      filled out about sexual desire and psychosocial, relational en sexual parameters. Also the
      sexual desire of the partner is questioned. On a three-monthly basis, blood samples are drawn
      to determine changes in hormonal parameters (one sample per product period).

      75 lesbian women are doing the same trial, but during an extra 3 months period, they are
      asked to have their natural menstrual cyclus as a control condition. Blood samples during
      these extra months will be drawn at the third or fourth day after start of the menses.
    


Intervention name(s): Nuvaring; low-dose combination pill; minipill
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: NuvaRing
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Healthy women
Efficacy and Safety Study of SHR117887 in Combination With Metformin in Patients With Type 2 Diabetes
Condition: Type 2 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 2

Summary: 
      SHR117887 is a new dipeptidyl peptidase(DPP)-4 inhibitor. This study aims to evaluate the
      efficacy and safety of SHR117887 in combination therapy with Metformin in patients with Type
      2 Diabetes in Metformin monotherapy Who have Inadequate Glycemic Control
    


Intervention name(s): Placebo; SHR117887
Intervention type(s): Drug; Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: SHR117887, Metformin,combination,PhaseII
Study to Evaluate Pharmacokinetic Drug Interactions and Safety of Clarithromycin, Amoxicillin and Ilaprazole
Condition: Drug Interaction Potentiation
Study type: Interventional
Phase: Phase 1

Summary: 
      This study evaluate the pharmacokinetic drug interaction in Ilaprazole, Clarithromycin,
      Amoxicillin.
    

Detailed description: 
      This study evaluate the pharmacokinetic drug interaction and safety in Ilaprazole,
      Clarithromycin, Amoxicillin.
    

Intervention name(s): Ilaprazole 10mg; Clarithromycin 500mg; Amoxicillin 500 Mg
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Period 1: Ilaprazole 10mg, one a day, one day Period 2: Ilaprazole 10mg, twice a day, 6 days; Period 1: Clarithromycin 500mg 1 tab., twice a day, one day Period 2: Clarithromycin 500mg 1 tab., one a day at 5 day; Period 1: Amoxicillin 500mg 2 cap., one a day, one day Period 2: Amoxicillin 500mg 2 cap., one a day at 5 day
Other intervention name(s): Noltec(the brand name); Klaricid 500mg(the brand name); Amoxicillin Cap. 500mg Chongkundang(the brand name)
Intervention MeSH terms: Amoxicillin; Clarithromycin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Trial to Investigate the Impact of Nocturnal Hypoglycaemia on Sleep in Subjects With Type 2 Diabetes
Condition: Diabetes; Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypoglycemia
Study type: Interventional
Phase: Phase 1

Summary: 
      This trial is conducted in Europe. The aim of this trial is to investigate the impact of low
      blood sugar during the night on sleep in subjects with type 2 diabetes.
    


Intervention name(s): glucose clamp
Intervention type(s): Other
Intervention description(s): Each subject will complete one adaptation night visit followed by two experimental night visits, one normoglycaemic and one hypoglycaemic, in randomised order. While subjects are asleep, sleep patterns will be monitored online using polysomnographic recordings during a hypoglycaemic and a normoglycaemic clamp (using constant intravenous (i.v.) infusion of human soluble insulin (Actrapid®)). Plasma glucose will be monitored.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Diagnostic
Treatment of AIDS Vacuolar Myelopathy With Methionine
Condition: Myelopathy; AIDS-Myelopathy; AIDS Vacuolar Myelopathy
MeSH terms: Spinal Cord Diseases; Bone Marrow Diseases
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to determine whether methionine, an amino acid present in low
      doses in the normal diet, can improve myelopathy or stop its progression.
    

Detailed description: 
      Myelopathy is usually a late complication of AIDS, and until recently its symptoms were
      rarely recognized, masked by the general state of disability or the presence of other
      neurological complications. With prolonged survival and improved quality of life of
      HIV-infected patients, myelopathy is increasingly becoming a common source of disability. The
      cause of AIDS-myelopathy is unknown, but it is probably an indirect effect of the long-term
      presence of the HIV virus in the nervous system rather than the result of a direct infection.
      The purpose of this study is to determine whether methionine, an amino acid present in low
      doses in the normal diet, can improve myelopathy or stop its progression.
    

Intervention name(s): methionine
Intervention type(s): Drug
Allocation: Randomized
Masking: Double
Primary purpose: Treatment
Keywords: myelopathy; AIDS-myelopathy; AIDS vacuolar myelopathy; methionine
Cervical Spinal Cord Stimulation for the Prevention of Cerebral Vasospasm
Condition: Aneurysmal Subarachnoid Hemorrhage
MeSH terms: Subarachnoid Hemorrhage; Vasospasm, Intracranial; Hemorrhage
Study type: Interventional
Phase: Phase 1

Summary: 
      The study investigates safety, feasibility and effectiveness of cervical spinal cord
      stimulation (SCS) in prevention of cerebral arterial vasospasm following aneurysmal
      subarachnoid hemorrhage (aSAH).

      It is postulated that 2 week long stimulation of the cervical spinal cord using an implanted
      epidural electrode will prevent or decrease severity of cerebral arterial vasospasm following
      aSAH.
    

Detailed description: 
      Continuous stimulation of the cervical spinal cord for 14 days after electrode implantation
      (within 3 days after aneurysmal subarachnoid hemorrhage). The single-arm single-institution
      non-randomized prospective study evaluates effects of cervical spinal cord stimulation on
      prevention of cerebral arterial vasospasm.

      The patients are followed for 12 months after completion of stimulation.
    

Intervention name(s): spinal cord stimulation
Intervention type(s): Device
Intervention description(s): electrode is inserted into cervical epidural space for continuous spinal cord stimulation
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: vasospasm; spinal cord stimulation; aneurysm; subarachnoid hemorrhage
Effect of Aerobic Exercise Training on Balance, Walking Capacity, and Quality of Life in Sub-acute Stroke.
Condition: Cerebrovascular Stroke; Cerebrovascular Accident, Acute; Cerebral Stroke
MeSH terms: Stroke
Study type: Interventional

Summary: 
      Stroke is one of the major cause of morbidity and mortality and the leading cause of
      disability in adults all around the world. Stroke survivors can suffer several neurological
      impairments and deficits which have an important impact on patient's quality of life and
      which increase the costs for health and social services. After stroke, impairments in ADLs
      and functional status, deterioration in health related quality of life can be seen.

      The purpose of this study is to Determine the effect of Aerobic exercise training on Balance,
      Walking capacity and quality of life in sub-acute stroke.
    


Intervention name(s): Combined Therapy (Aerobic Exercise in addition to conventional therapy)
Intervention type(s): Other
Intervention description(s): There are two intervention arm in the study
Combined therapy
Conventional Therapy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Aerobic exercise; Stroke; Walking Capacity
Phase I Clinical Trial for Comparison of Pharmacokinetic Characteristics of Vorico Injection 200mg(Voriconazole) and Vfend® IV 200mg for Single Dose Crossover Intravenous Infusion in Healthy Volunteers
Condition: Aspergillus Infections; Candida Infections; Fungal Infections
MeSH terms: Infections; Communicable Diseases; Mycoses; Candidiasis; Aspergillosis
Study type: Interventional
Phase: Phase 1

Summary: 
      Phase I Clinical Trial for Comparison of Pharmacokinetic Characteristics of Vorico Injection
      200mg(Voriconazole) and Vfend® IV 200mg for Single Dose Crossover Intravenous Infusion in
      Healthy Volunteers
    

Detailed description: 
      To healthy volunteers subjects of twenty four(24), following treatments are administered
      dosing in each period injected wash-out period is a minimum of 7days. Treatment A(Test Drug):
      Vorico Injection 200mg(Voriconazole) for Single Dose Treatment B(Reference Drug): Vfend® IV
      200mg for Single Dose Pharmacokinetic blood samples are collected up to 24hrs.

      Safety and pharmacokinetic are assessed.
    

Intervention name(s): Vorico Injection 200mg(Voriconazole); Vfend®(Voriconazole) IV 200mg
Intervention type(s): Drug; Drug
Intervention description(s): Vorico Injection 200mg(Voriconazole) to administered intravenously once; Vfend®(Voriconazole) IV 200mg to administered intravenously once
Intervention MeSH terms: Voriconazole
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Study to Evaluate ACT-132577 in Healthy Subjects and in People With Severe Kidney Disease
Condition: Severe Renal Impairment; Healthy Subjects
MeSH terms: Renal Insufficiency
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary purpose of this study is to investigate the fate of ACT-132577 in healthy
      subjects and in people with severe kidney disease
    


Intervention name(s): ACT-132577
Intervention type(s): Drug
Intervention description(s): Capsule
Other intervention name(s): Aprocitentan
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Study to Assess Potential Immune Interference When GlaxoSmithKline (GSK) Biologicals' MenABCWY Vaccine is Administered to Healthy Subjects Aged 10-25 Years
Condition: Meningitis, Meningococcal
MeSH terms: Meningitis, Meningococcal; Meningitis
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of the current study is to evaluate whether there is immune interference when
      MenABCWY [consisting of MenACWY lyophilized component and rMenB+OMV NZ (Bexsero) liquid
      component] is administered to healthy adolescents and adults following a 2-dose vaccination
      schedule with MenABCWY administered 2 months apart.
    


Intervention name(s): MenABCWY vaccine; rMenB+OMV NZ (Bexsero) vaccine; MenACWY (Menveo) vaccine
Intervention type(s): Biological; Biological; Biological
Intervention description(s): Two doses administered intramuscularly in the deltoid region of the non-dominant arm.; Two doses administered 2 months apart intramuscularly in the deltoid region of the non-dominant arm to subjects randomised to the rMenBOMV+ACWY_S Group, rMenBOMV+ACWY_D Group and rMenBOMV Group; Two doses administered intramuscularly in the deltoid region of the dominant/non-dominant arm to subjects randomised to the rMenBOMV+ACWY_S Group and rMenBOMV+ACWY_D Group and one dose administered intramuscularly in the deltoid region of the dominant/non-dominant arm to subjects randomised to the MenACWY Group
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Meningitis; Concomitantly; Adolescent; Neisseria meningitidis; Healthy subjects; Adult
Clinical Study of KW-2246 in Patients With Cancer Pain
Condition: Pain; Cancer
MeSH terms: Cancer Pain
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is a Phase II open-label study to investigate the recommended conversion ratio
      (oral morphine dose to KW-2246) when switching oral morphine or oxycodone to KW-2246 in
      cancer patients.
    

Detailed description: 
      This study is a Phase II open-label study to investigate, using the continual reassessment
      method procedure by pain intensity and safety as indicators, the recommended conversion ratio
      (oral morphine dose to KW-2246) when switching oral morphine or oxycodone to KW-2246 in
      cancer patients who have been maintained on oral morphine or oral oxycodone for pain and to
      evaluate the safety and efficacy of KW-2246.
    

Intervention name(s): KW-2246 (fentanyl citrate)
Intervention type(s): Drug
Intervention description(s): KW-2246
Other intervention name(s): Fentanyl citrate
Intervention MeSH terms: Fentanyl; Citric Acid; Sodium Citrate
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Pain; Cancer; Neoplasm; Continual Reassessment Method; Pain Associated with Cancer/Neoplasms
Patent Foramen Ovale in Cryptogenic Stroke Study
Condition: Ischemic Stroke; Patent Foramen Ovale
MeSH terms: Stroke; Ischemic Stroke; Foramen Ovale, Patent
Study type: Interventional
Phase: Phase 4

Summary: 
      The study sought to assess the rate of recurrent stroke and death in stroke patients with a
      patent foramen ovale randomized to treatment with warfarin or aspirin. This was a multicenter
      study conducted at 48 U.S. Institutions.
    


Intervention name(s): Warfarin; Aspirin
Intervention type(s): Drug; Drug
Intervention description(s): Warfarin once a day, titrated to obtain an INR of 1.4 to 2.8; placebo aspirin once a day; Aspirin 325 mg once a day; placebo warfarin once a day
Other intervention name(s): Coumadin
Intervention MeSH terms: Aspirin; Warfarin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: cerebrovascular diseases; ischemic stroke; patent foramen ovale; warfarin; aspirin; transesophageal echocardiography
Evaluation Nutrition Education Intervention on Pulse and Cereal Mix for Complementary Food in Southern Ethiopia
Condition: Dietary Habits; Health Knowledge, Attitudes, Practices; Wasting
MeSH terms: Wasting Syndrome; Cachexia
Study type: Interventional

Summary: 
      The overall purpose of the study is to evaluate nutrition education interventions to promote
      pulse incorporated complementary food to the wider rural community through the government
      system to improve maternal knowledge, attitude and practice (KAP) and nutritional status of
      young children (6 to 24 months). The hypothesis is that nutrition education improves mothers
      knowledge, attitude and practice of pulse incorporated complementary food and improves
      dietary intake of iron and zinc and nutritional status of young children.
    

Detailed description: 
      Only 9% of the population in Southern Ethiopia consumes pulse and pulse total contribution of
      the diet is less than 4.9% for women and less than 3.3% for children.Young children are at
      risk of developing malnutrition because of dietary inadequacy. Educational interventions can
      improve feeding practices and growth of young children. The overall purpose of the study is
      to evaluate nutrition education interventions to promote pulse incorporated complementary
      food to the wider rural community through the government system to improve maternal
      knowledge, attitude and practice (KAP) and nutritional status of young children (6 to 24
      months). The hypothesis is that nutrition education improves mothers knowledge, attitude and
      practice of pulse incorporated complementary food and improves dietary intake of iron and
      zinc and nutritional status of young children. Before, at midline and end of the intervention
      we will assess the KAP of mothers, dietary intake of iron and zinc and nutritional status of
      young children. The nutrition education intervention will be given for 9 months. Serum
      ferritin, serum zinc, C-Reactive protein and hemoglobin and dietary intake of iron and zinc
      of young children will be measured at the beginning and ending of the intervention.
    

Intervention name(s): enhanced education on pulse use in complementary foods
Intervention type(s): Other
Intervention description(s): Enhanced Nutrition education with sessions and counseling by health extension workers
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Clinical Research Study Efficacy of a Prototype Oral Rinse
Condition: Dental Plaque
MeSH terms: Dental Plaque
Study type: Interventional
Phase: Phase 3

Summary: 
      Evaluate the efficacy of an oral rinse on dental plaque and gingival inflammation
    


Intervention name(s): Iodine; water
Intervention type(s): Drug; Other
Intervention description(s): Rinse 2 times per day for 6 weeks; Use 2 times per day for 6 weeks
Other intervention name(s): Iocide (proprietary company name); No actives present in control mouthrinse. (Flavored water)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Impact Of Smoking Cessation Treatment Reimbursement On The Quit Rates In Smokers Motivated To Quit
Condition: Smoking Cessation; Insurance Coverage
Study type: Interventional
Phase: Phase 4

Summary: 
      This study is based on the hypothesis that access to smoking cessation treatment (SCT)
      reimbursement may significantly increase the number of successful quitters in a population of
      smokers motivated to quit by: 1) increasing the use of SCTs in quit attempts, and 2) by
      improving subject adherence to treatment.
    


Intervention name(s): Full Smoking Cessation Treatment Coverage (100%); No Smoking Cessation Treatment Coverage (0%)
Intervention type(s): Other; Other
Intervention description(s): This is a pragmatic study in which the intervention is a health policy (SCT reimbursement). Champix (varenicline), Zyban (bupropion) and NRTs (nicotine replacement therapies; patches, gums) are SCT eligible for reimbursement. Prescriptions will be issued as per the most recent version of the Product Monograph of the prescribed SCT or equivalent.; None of the subjects recruited in the study have access to SCT reimbursement in real-life. As such, subjects randomized to the control group represent lack of SCT coverage in real-life and are considered to receive standard of care for smoking cessation.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Smoking cessation; quit rates; reimbursement; drug coverage; effectiveness; cost-effectiveness; health policy; drug utilization; adherence; urine cotinine.
A Study of HR071603(Ketamine Nasal Spray) in Healthy Subjects
Condition: Depression
MeSH terms: Depression
Study type: Interventional
Phase: Phase 1

Summary: 
      The study is being conducted to evaluate the safety and pharmacokinetics of HR071603 in
      healthy subjects.
    


Intervention name(s): HR071603; placebo
Intervention type(s): Drug; Drug
Intervention description(s): HR071603 monotherapy ,nasal spray; placebo,nasal spray
Other intervention name(s): R-ketamine
Intervention MeSH terms: Ketamine
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: HR071603 monotherapy
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Exercise in Severe Mental Illness. The PsychiActive Project
Condition: Exercise Therapy
MeSH terms: Mental Disorders
Study type: Interventional

Summary: 
      The purpose of this randomized controlled trial is to study the effects of exercise on body
      weight, body composition, anthropometric and fasting blood measures, physical fitness,
      pulmonary function, quality of life, and lifestyle habits in patients with severe mental
      illness.
    


Intervention name(s): Exercise
Intervention type(s): Behavioral
Intervention description(s): Exercise training for 12 weeks (aerobic and resistance training trice a week)
Other intervention name(s): Exercise training
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Examining The Effect of Blood Flow Restricted Aerobic Training on Mitochondrial Adaptations in Young Healthy Adults
Condition: Mitochondrial Biogenesis
Study type: Interventional

Summary: 
      This parallel-arm trial study investigates the effects of restricting arterial blood flow
      during cycling exercise on citrate synthase. Participants will be randomized to either a
      blood flow restricted or non-blood flow restricted exercise training group. Both groups will
      complete seven, 30-minute exercise sessions over a 14-day period.
    


Intervention name(s): BFR Exercise Training; CTL Exercise Training
Intervention type(s): Other; Other
Intervention description(s): Participants will complete exercise training on a recumbent bike placed on a 45 degree incline (BFR).; Participants will complete exercise training on a recumbent bike placed on flat ground (CTL).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Mitochondria; Exercise training; VO2; Aerobic exercise; Citrate Synthase; Blood flow restriction