bioihbjkbjnl/mcl2 huggingface dataset:
Development and Validation of the Periodontal Aesthetic Perception Scale in Patients With Periodontal Problems
Condition: Gingival Enlargement; Gingival Recession
MeSH terms: Gingival Recession; Gingival Hyperplasia; Gingival Hypertrophy; Gingival Overgrowth
Study type: Observational

Summary: 
      Aesthetics for individuals become increasingly important, while the aesthetic effects of
      periodontal disease is an important issue that should be assessed by the patient's
      perception.

      The results demonstrate that the periodontal aesthetic perception scale showed reliable and
      valid scores in healthy controls and periodontal patients.

      The periodontal aesthetic perception scale may be an appropriate tool to assess periodontal
      esthetic in clinical and research settings.
    

Detailed description: 
      Aim: The aim of this study is to develop and validate a periodontal aesthetic specific tool
      to assess aesthetic conditions perceived by patients with periodontal problems.

      Methods: With patient interviews were identified a total of 22 statements that describe the
      non-aesthetic gingival appearance. These 22 items were reviewed by the dentists and then
      Periodontologists and the number of items in the survey was reduced to 7. Subsequently, three
      groups of patients were included in the study: Gingival recession (GR) group, gingival
      enlargement (GE) group and periodontal healthy (H) group. Consequently, the validity and
      reliability of the periodontal aesthetic perception scale (PAPS) were examined.

      Results: According to the results of the Exploratory Factor Analysis (EFA), 1 item was
      removed from the scale. The final 6-item questionnaire was shown to have a two-domain
      structure. Cronbach's alpha for the whole scale was .766. The interclass correlation
      coefficients (ICCs) values were between 0.98 and 1.00, demonstrating excellent agreement.
      Overall, these findings indicated that the PAPS has good reliability.

      Conclusion: This reliable, valid and short questionnaire specific to aesthetic conditions
      perceived by patients with periodontal problems may serve as a valued instrument in future
      clinical trials.
    

Intervention name(s): Periodontal Aesthetic Perception Scale
Intervention type(s): Other
Intervention description(s): Patients answered the self-reported 7-item questionnaire for Periodontal aesthetic perception scale
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Patients who fulfilled the criteria for inclusion presenting at the periodontology clinic
        were asked to participate in the study and those agreeing to interview were asked how and
        what aesthetically disturbing symptoms in their gingiva.
      
Keywords: aesthetic; development; periodontal; reliability; validity
A Study to Determine the Inter/Intra Observer and Intra-subject Variability of Whole Blood Clotting Time Measurements
Condition: Healthy
MeSH terms: Thrombosis
Study type: Interventional

Summary: 
      The purpose of the study is to characterize the distribution and sources of variability in
      whole blood clotting time (WBCT) measurements in human blood collected from healthy
      volunteers by 5 different technicians.
    

Detailed description: 
      No investigational product was administered to any subject in this study.
    

Intervention name(s): Single-arm
Intervention type(s): Other
Intervention description(s): collection of blood for assessment of whole blood clotting time
Other intervention name(s): Whole Blood Clotting Time assessment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: whole blood clotting time
Evaluation of the Marginal Integrity of Recent Bulk Fill Flowable Composite vs Glass Ionomer for Carious Cervical Restorations: RCCT
Condition: Dental Caries Class v
MeSH terms: Dental Caries
Study type: Interventional

Summary: 
      The study will be conducted to assess the marginal integrity of different types of
      restorations (ketac ™ N100 - ketac™ Universal and bulk fill flowable composite) in class v
      restoration using USPHS criteria.
    


Intervention name(s): restorative materials
Intervention type(s): Other
Intervention description(s): glass ionomer and bulk fill flowable composite
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 3 parallel groups
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Postoperative Pain Relief After Major Abdominal Gynecological Surgery
Condition: Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional
Phase: Phase 4

Summary: 
      The aim of our study was to compare the effects of Lomber Epidural Analgesia (LEA),
      Transversus Abdominis Plane (TAP) block and Local Anesthetic Infiltration (LAI) on
      postoperative morphine consumption, time to first recue analgesic request, pain and patient
      satisfaction scores and side effects were compared in the patients undergoing major
      gynecologic/oncology lower abdominal surgery.
    

Detailed description: 
      Following faculty ethical committee approval and written informed consent, 81 patients were
      included in our prospective, randomized and double-blind study. Patients were divided into 3
      groups: lumbar epidural block (Group E), TAP block (Group T), and wound infiltration (Group
      I). Demographic data, surgical characteristics, hemodynamic values, pain scores at rest and
      on movement, morphine consumption, additional analgesic requirement, side effects at 1, 2, 6,
      12, 24, 36 and 48th hours after surgery, and patient satisfaction scores at 24 and 48th hours
      were recorded.
    

Intervention name(s): postoperative analgesic methods
Intervention type(s): Procedure
Intervention description(s): lumbar epidural analgesia Transversus abdominis plane block wound infiltration
Intervention MeSH terms: Analgesics
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: epidural analgesia; pain score; morphine; transversus abdominis plane block; wound infiltration
The Safety and Efficacy of Using HYADERMIS LA for Wrinkle Correction
Condition: Pain; Nosalabial Folds Correction
Study type: Interventional

Summary: 
      The study is a double-blind, randomized, within-subject controlled, 2-armed, single-centre
      study sponsored by SciVision Biotech Inc. and approved by Yuan's General Hospital
      Institutional Review Board. The aim of this post-marketing study is to evaluate the safety
      and efficacy of HYADERMIS LA facial dermal implant for the improvement of nasolabial folds.

      The study was estimated to be held half to one year including a 0-2 weeks screening period, a
      day of treatment, and follow-up at week 1 and 2. Patient informed consent forms will be
      obtained before volunteers enter screening period. If the volunteers meet all the criteria,
      they will be given a number to replace their name in the study. The participants will be
      randomised assigned to receive experiment treatment, HYADERMIS LA, in one side of nasolabial
      folds and control treatment, Hya-Dermis, in the other side of the face. The safety assessment
      evaluated any recorded adverse events following the device treatments either by blinded
      evaluator or subjects. The effectiveness of the treatment devices will be assessed by using
      photographic assessment, nasoalabial folds severity scale, global aesthetic improvement
      scale, and pain visual analog scale.
    


Intervention name(s): lidocaine contained hyaluronate facial dermal filler; hyaluronate facial dermal filler
Intervention type(s): Device; Device
Intervention description(s): HYADERMIS LA Facial Dermal Implant contains 20 mg/ml hyaluronate and 0.3 % lidocaine.; Hya-Dermis Facial Dermal Implant contains 20 mg/ml hyaluronate.
Other intervention name(s): HYADERMIS LA Facial Dermal Implant; Hya-Dermis Facial Dermal Implant
Intervention MeSH terms: Lidocaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Natural Cycle Versus Endometrial Preparation for Healthy Blastocyst Transfer
Condition: Infertility
MeSH terms: Infertility
Study type: Interventional

Summary: 
      This study evaluates the difference in pregnancy rate transferring a healthy blastocyst in
      natural or artificial cycle.
    

Detailed description: 
      The aim of the study was to verify the implantation capacity and ongoing pregnancy rate of
      vitrified warmed euploid blastocyst in natural cycle versus endometrial artificial cycle with
      gonadotropin-releasing hormone (GnRH-agonist) pituitary suppression.
    

Intervention name(s): embryo transfer
Intervention type(s): Other
Intervention description(s): healthy blastocyst transfer in natural and hormonal cycle
Other intervention name(s): drug adminstration, clinical controls
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Clinical Evaluation of Medasense Pain Monitor Performances
Condition: Surgery; Pain; Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Observational

Summary: 
      In this study, the performances of Medasense's non-invasive pain monitoring is compared with
      standard pain related indicators, such as heart rate, galvanic skin response, etc. , and with
      a subjective pain level assessment. The subjective pain level is assessed by the
      anesthesiologist when the patient is under general anesthesia and by the patient and a nurse
      in post anesthetic care unit (PACU).

      The study is based on recording and analyzing the subject's physiological signals, while
      recording painful events, medication dosing and different clinical signs.
    

Detailed description: 
      Pain is an unpleasant sensation, ranging from slight discomfort to intense suffering. Since
      pain is a subjective phenomenon, it has frequently defied objective, quantitative
      measurements. Today, in order to measure pain, subjective uni-dimensional scales are used to
      quantify pain. One of the most common scale used to rate a patient's pain intensity is the
      visual analog scale (VAS), usually scored from 0 to 100. Hitherto, those scales are based on
      the subjective evaluation of pain by the patient.

      During anesthesia the patient cannot communicate and therefore the verbal or other report is
      impossible. Therefore, due to misrepresentation of the existence or extent of pain, care
      providers may fail to estimate the correct measure of pain and give too much or too little
      medication. A scoring system of pain level is therefore needed. That is the problem
      Medasense's system tries to approach.

      In this study investigators intend to test and analyze the performances of Medasense pain
      monitor by comparing its results with standard pain related indicators and with subjective
      patient's pain level assessment. The patient's pain level will be assessed by the
      anesthesiologist during surgery based on known pain stimuli, medications administered and
      clinical signs, and by the PACU nurse and patient's reports, when the patient is in recovery.
    

Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Patients scheduled for elective surgeries under general anesthesia, healthy or suffering
        from minor chronic diseases (ASA I-II)
A Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-SK-1405
Condition: Pruritus
MeSH terms: Pruritus
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objectives of the study are:

        -  To assess the mass balance recovery after a single PO dose of [14C]-SK-1405

        -  To provide plasma, urine and faecal samples for metabolite profiling and structural
           identification
    


Intervention name(s): [14C]-SK-1405
Intervention type(s): Drug
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Transcutaneous Electrical Acupoint Stimulation (TEAS) on Prevention Hypotension in Elderly
Condition: Hypotension
MeSH terms: Hypotension
Study type: Interventional

Summary: 
      Despite prophylactic measures, hypotension remains a common side-effect of spinal anesthesia.
      Electroacupuncture influences hemodynamics. We hypothesized that transcutaneous electrical
      acupuncture point stimulation (TEAS) at traditionally used acupuncture points would reduce
      the severity of hypotension after spinal anesthesia in geriatric patients undergoing hernia
      surgery.
    

Detailed description: 
      After obtaining written informed patient consent, 60 geriatric patients undergoing hernia
      surgery under spinal anesthesia were randomized into two groups. In the placebo TEAS group,
      the gel electrodes will be applied at the same anatomical points without stimulation. The
      acupoint group will receive TEAS at the PC-5, PC-6, and ST-36 points bilaterally before the
      spinal anesthesia. The spinal anesthesia will be performed using 12.5 mg 0.5% bupivacaine was
      from the L3-4 or L4-5 interval with a 25G Quincke spinal needle. Hemodynamic data will be
      followed every five minutes.
    

Intervention name(s): Transcutaneous Electrical Acupoint Stimulation
Intervention type(s): Device
Intervention description(s): Transcutaneous Electrical Acupoint Stimulation
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Prevention
PHS, Lichtenstein Mesh, and PerFixPlug for Primary Inguinal Hernia Repair - 3 Years Results
Condition: Hernia, Inguinal
MeSH terms: Hernia; Hernia, Inguinal
Study type: Interventional
Phase: Phase 4

Summary: 
      Three different techniques for the surgical repair of groin hernias are compared. Focus has
      been set on operation times, time to full return of functional abilities like walking in
      stairs etc, and if any technique has more complications than the others. Three years results
      are presented in the study.
    

Detailed description: 
      Dissection requirements differ between various methods for inguinal hernia repair, which may
      effect operation times, pain response and possibly recovery time. The objectives of this
      study were to establish if any differences concerning these aspects could be detected after
      three principally different techniques for primary inguinal hernia repair.

      472 men between 30 and 75 years with primary inguinal hernias were included in a prospective
      controlled study and randomised to Lichtenstein mesh (L), PerFix Plug® (P) or the Prolene®
      Hernia System (PHS) procedure. All patients were seen and data were collected after 2 weeks,
      3 months, 1 year, and 3 years.
    

Intervention name(s): Lichtenstein mesh; PerFix Plug®; Prolene® Hernia System
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): The different techniques are compared and evaluated according to primary and secondary objectives.; The different techniques are compared and evaluated according to primary and secondary objectives.; The different techniques are compared and evaluated according to primary and secondary objectives.
Other intervention name(s): Inguinal hernioplasty (surgical repair of inguinal hernia); Inguinal hernioplasty (surgical repair of inguinal hernia); Inguinal hernioplasty (surgical repair of inguinal hernia)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Inguinal hernia; Randomized controlled trial; Surgery; Complications; Surgical mesh
Effect of Dental Pulp Stem Cells and L-PRF After Impacted Third Molar Extraction
Condition: Stem Cell; Third Molar; Periodontal Pocket
MeSH terms: Periodontal Pocket
Study type: Interventional

Summary: 
      The purpose of this study is to compare the clinical and radiographic effectiveness of
      Leukocyte-Platelet Rich Fibrin (L-PRF) and L-PRF combined with dental pulp stem cell (DPSC)
      application to the extraction socket of mandibular third molars.
    

Detailed description: 
      Patients aged between 18 and 30 years, seeking for bilateral impacted LM3 extraction
      surgeries and meeting eligibility criteria were included to the study. At baseline right and
      left impacted third molars (LM3s) were randomly assigned to one of the treatment group (L-PRF
      and L-PRF + DPSC). Baseline and 6th month clinical and radiographic measurements were
      compared.
    

Intervention name(s): L-PRF + DPSC; L-PRF
Intervention type(s): Procedure; Procedure
Intervention description(s): After surgical removal of impacted mandibular third molars, extraction sockets were filled with L-PRF membranes + DPSCs.; After surgical removal of impacted contralateral mandibular third molars, each extraction sockets were only filled with L-PRF membranes.
Other intervention name(s): Leukocyte platelet rich fibrin plus dental pulp stem cells; Leukocyte platelet rich fibrin
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Prospective within person randomised split-mouth study. Left and right surgical sites for each participant were randomized using an online generated list to determine test and positive control LM3. (http://www.randomization.com). LM2s and LM3 extraction sockets were divided into two groups: a test group (extraction sockets filled with L-PRF membranes + DPSCs) and a control group (extraction sockets filled with L-PRF membranes).
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: dental pulp; stem cell; third molar; Platelet-rich fibrin
Iodine Content for Diagnostic AccuRacy and Patient Comfort For Individuals Undergoing Cardiac Computed Tomography (CT) Scanning
Condition: Coronary Arteriosclerosis
MeSH terms: Arteriosclerosis; Coronary Artery Disease; Myocardial Ischemia
Study type: Observational

Summary: 
      The purpose of the study is to evaluate diagnostic performance of high iodine (iopamidol 370
      mg/dl) content versus low iodine (iodixanol 300 mg/dl) content for diagnostic accuracy by
      contrast-enhanced Coronary Cardiac Computed Tomography (CCTA) using a 64-detector-row CT
      scanner for detection of presence or absence of coronary artery obstruction when compared
      against invasive coronary angiography, the standard of truth.
    

Detailed description: 
      Coronary Cardiac CT (CCTA) is a widely accepted modality for non-invasive evaluation of
      coronary atherosclerosis. The diagnostic performance of CCTA for detecting coronary artery
      plaque burden has been validated in numerous studies, reaching a negative predictive value of
      99%.

      The current gold standard for anatomic coronary imaging is Invasive Coronary Angiography
      (ICA) which portends a small but significant procedural-related complication of 1.7%.
      Non-invasive coronary imaging has the potential to replace ICA but the variability in
      diagnostic performance of CCTA remains under study. Among the potential variables causing
      differences in diagnostic performance is perhaps the degree of opacification of coronary
      artery by iodinated contrast. While numerous contrast agents exist, those that provide
      improved low and high contrast resolution (for delineating plaque from arterial wall and
      lumen from plaque, respectively) are hypothetically, the most optimal agents. To date,
      however, this has not been well evaluated. Further, use of a contrast agent which maximizes
      patient comfort is desired, as this may reduce heart rate increases and heart rate
      variability, which may in turn improve diagnostic image quality of CCTA.

      We hypothesize that the use of lower iodine content iso-osmolar agent - iodixanol - will
      improve diagnostic performance and patient comfort, as compared to higher iodine content low
      osmolar iodinated contrast - iopamidol.
    

Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Subjects are over 18 years or older. They have been referred to a cardiologist for
        suspected CAD and then scheduled for an elective invasive coronary angiography.
      
Keywords: CCTA; Coronary Artery Stenosis; Iodinated Contrast; Invasive Coronary Angiography
Pituitary Gland Enlargement Was First Diagnosed by Optical Coherence Tomography (OCT)
Condition: Pituitary Mass; Diagnoses Disease
MeSH terms: Pituitary Diseases
Study type: Observational

Summary: 
      OCT is now an established way to measure the thickness of the Retinal Nerve Fiber Layer
      (RNFL) in the retina of the eye. The thickness of the RNFL is always a reflection of the
      number of the RNFs in any particular area of the retina. Each single RNF runs a long course
      starting from the cell body which is the retinal ganglion cell in the retina and ends in the
      thalamus of the brain where it relays visual information to other nerve cell in the thalamus.
      Along this long course RNFs are in close anatomical relationship with the pituitary gland
      crossing just above this gland about midway along their course. Hence enlargement of this
      gland can interfere with the RNFs.
    

Detailed description: 
      The inferior chiasmal syndrome is known to be caused by pituitary gland enlightenment because
      the pituitary gland lies just below the optic chiasma. The visual RNFs are organized in a
      very specific way along their long course from the retina to the Lateral Geniculate Body
      (LGB) in the thalamus. Pituitary enlargement would compromise particular RNFs. It is well
      known and established that pituitary enlargement, if not properly treated in time, would
      possibly cause bitemporal hemianopia due to interference with the crossing RNFs of the nasal
      half of each retina. In this study pituitary enlargement was suspected by OCT findings while
      the patient still had perfect peripheral visual field in each eye.
    

Intervention name(s): Optical Coherence Tomography (OCT)
Intervention type(s): Diagnostic Test
Intervention description(s): OCT is used to measure thickness (numbers) of retinal nerve fibres in different areas of the retina
Observational model: Case-Only
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Any patient who presents with frequent or persistent headache of unknown reason.
D-MPH in the Treatment of Fatigue and Neurobehavioral Function Related to Chemotherapy in Adult Cancer Patients
Condition: Fatigue; Neoplasms
MeSH terms: Fatigue
Study type: Interventional
Phase: Phase 2

Summary: 
      To evaluate the efficacy of dexmethylphenidate (d-MPH) in the treatment of
      chemotherapy-related fatigue in adult cancer subjects.
    


Intervention name(s): dexmethylphenidate(d-mph)
Intervention type(s): Drug
Intervention MeSH terms: Dexmethylphenidate Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: neurobehavioral function; chemobrain; chemo brain; fatigue; memory loss; exhausted; trouble concentrating