The Effect of Exercise on Dialysis Patients' Survival
Condition: Kidney Disease, Chronic; End Stage Renal Disease; Hemodialysis
MeSH terms: Kidney Diseases; Kidney Failure, Chronic; Renal Insufficiency, Chronic
Study type: Interventional

Summary: 
      The purpose of this study is to check if patients' exercise during their dialysis sessions
      can prevent their early deaths.
    

Detailed description: 
      Dialysis patients suffer from a number of problems, one of which is reduced ability,
      decreased functional capacity, and consequently reduced physical capability. Forced
      inactivity due to immobility in dialysis sessions and the need to rest and relieve fatigue
      for a few hours after each session cause patients to become more inactive day by day, and
      according to various studies, inactivity in these patients along with reduced physical
      capabilities increase the risk of cardiovascular disease, which is a risk factor for
      mortality in these patients.

      On the other hand, inactivity is an independent predictor of hospitalization and mortality in
      these patients.

      Studies have shown that exercise can produce many different effects in these patients.
      However, exercise interventions are often short-term, and even in long-term cases, the aim of
      studies is only to examine a number of hematological factors or factors such as functional
      capacity in these patients.

      A study is currently being designed to directly evaluate the impact of exercise on patients'
      survival.

      To test this hypothesis, patients do exercise for 6 months during dialysis. And then will be
      monitored for a year to determine patients' survival.

      During 6 months of intervention, hematological parameters, nutrition index and functional
      capacity of patients are evaluated.

      In the analyzes, the survival rate of patients in one year follow-up period is compared
      between patients who took part in intradialytic sessions (intervention group) and patients
      who did not do any physical activity during dialysis (control group). In addition, by
      analyzing the variables measured during the 6 months of the intervention, the effect of
      exercise on parameters relating to survival is evaluated.
    

Intervention name(s): Intradialytic Exercise
Intervention type(s): Other
Intervention description(s): Participants will do concurrent exercise (a combination of aerobic exercise and resistance training) for 30-60 minutes during the second hour of their routine hemodialysis sessions.
To determine the intensity of the prescribed exercise, maximum heart rate is used for aerobic workout and 1RM for resistance protocols.
Exercises will be performed at a moderate exercise intensity (12-14 on the Borg RPE Scale).
All protocols are tailor-made based on each individual's needs and physical abilities.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants will be randomly allocate to intervention group or control group and will be examined in the same way.
Masking: Single (Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: mortality; exercise during dialysis; physical function; sarcopenia; hematological parameters