Compare Effects of Dressing With Honey and EUSOL
Condition: Necrotizing Fascitis; Wound Infection
MeSH terms: Wound Infection; Fasciitis; Fasciitis, Necrotizing
Study type: Interventional

Summary: 
      Honey is super saturated solution containing sugar derived from nectar gathered by honeybee.
      Honey is viscus supersaturated solution mainly composed of sugar and water along with minor
      constituents such as minerals, vitamins, amino acids, organic acids, flavonoids, and other
      phenolic compound and aromatic substances. Honey contents according to percentages are
      fructose 38.6%, glucose 31%, water 17%, lactose 7.2%, larger sugars 4.7% and rest of
      micronutrients and elemental compounds are 1.5%. Honey enhances wound healing by removing
      slough and necrotic tissue from wound. It promotes wound healing by increasing angiogenesis,
      granulation and epithelization. Honey possess antimicrobial activity against bacteria like
      methicillin resistant staphylococcus aureus, vancomycin resistant Escherichia Coli,
      pseudomonas aeruginosa, and many other species. It also has activity against some yeast
      species such as aspergillus and penicillium.

      Honey used for dressing will be 'Langnese Honey". Langnese honey is raw honey / unprocessed
      packed as collected, quality and quantity will be same for patients.
    

Detailed description: 
      This prospective randomized trial will be conducted in all patients undergoing dressing after
      debridement of necrotizing fasciitis wounds. Study will be conducted for 6 months after
      approval IRB. Patient will be inducted through emergency department. After debridement,
      patient will be enrolled in study via simple random sampling for dressing with either EUSOL
      or Honey. Honey quantity for wound will be 4ml per square inch. In patient whose both limbs
      involved by necrotizing fasciitis, after debridement, dressing will be done with honey in one
      limb and EUSOL in other limb. Patient will be enrolled in study whose debridement already
      done.

      EUSOL is solution commonly used for dressing of wounds. Honey is also used for dressing of
      wounds. Honey is a viscous, supersaturated sugar derived from nectar gathered by a honeybee.
      Honey enhances wound healing by providing moist environment, antibacterial activity,
      deodorizes, decrease inflammation, edema and exudation. Honey increase rate of wound healing
      by promoting angiogenesis, granulation and epithelization. Dressing will be done by residents
      of our ward under supervision of faculty. At first time of debridement pus or tissue will be
      sent for culture and sensitivity meanwhile broad-spectrum antibiotic will be started. Once
      dressing will started, wide wound span will be measured and assessed daily for granulation
      tissue and removal of slough. Questionnaire will be filled by PI for allergic reaction to
      solution, appearance of granulation tissue and hospital stay.
    

Intervention name(s): Honey; EUSOL
Intervention type(s): Drug; Combination Product
Intervention description(s): Dressing of necrotizing fascitis wounds with honey.; Dressing of necrotizing fascitis wounds with EUSOL.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Experimental randomised trial
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment