Effect of Platelet Rich Plasma (PRP) on Healing Time in Patients Following Pilonidal Sinus Surgery
Condition: Pilonidal Disease; Pilonidal Sinus
MeSH terms: Pilonidal Sinus
Study type: Interventional

Summary: 
      Our study was planned as a prospective controlled randomized study. The study was started
      after the ethics committee approval received from Dışkapı Yıldırım Beyazıt Training and
      Research Hospital. (23.08.2021 118/01). Two groups of patients were planned in parallel. In
      the treatment of pilonidal sinus disease, in patients operated on with the fistulotomy and
      curettage technique, one group was followed up with classical dressing, while the other group
      was followed up with PRP (platelet-rich-plasma) and classical dressing. Wound infection,
      hematoma, length of hospital stay, recurrence, pain in the first postoperative week, and time
      to complete epithelialization of the wound (in days) were evaluated between the two groups.
    

Detailed description: 
      Our study was planned as a prospective controlled randomized study. The study was started
      after the ethics committee approval received from Dışkapı Yıldırım Beyazıt Training and
      Research Hospital. (23.08.2021 118/01). Two groups of patients were planned in parallel. In
      the treatment of pilonidal sinus disease, in patients operated on with the fistulotomy and
      curettage technique, one group was followed up with classical dressing, while the other group
      was followed up with PRP (platelet-rich-plasma) and classical dressing. Wound infection,
      hematoma, length of hospital stay, recurrence, pain in the first postoperative week, and time
      to complete epithelialization of the wound (in days) were evaluated between the two groups.

      A total of 140 patients, male and female, diagnosed with pilonidal sinus disease in our
      hospital between November 2021 and November 2022 were included in the study. Patients with
      acute pilonidal sinus abscess were excluded from the study, but chronic PS(pilonidal sinus)
      patients who had previously undergone abscess drainage were included in the study.

      Patients under 18 years of age, relapsed patients, anemic patients (Hg < 10 mg/dl),
      thrombocytopenic patients (Plt˂10⁶/ml), patients with a history of radiotherapy-chemotherapy,
      patients with diabetes and patients using steroids were excluded from the study.

      Randomization was performed using the PASS computer program, and according to this
      randomization, fistulotomy and curettage technique (n=70) was applied to one group and
      fistulotomy and curettage + PRP (n=70) was applied to the other group.

      Demographic information, family history, smoking, presence of abscess drainage, post-drainage
      antibiotic use, comorbidities, BMI, symptom duration, phenol application, laser epilation,
      number of sinus pits, presence of secondary orifice, basal PLT(platelet) count, size of the
      defect after sinus excision, wound infection, hematoma, length of hospital stay, presence of
      recurrence, pain in the first postoperative week, and time to complete epithelialization were
      evaluated.
    

Intervention name(s): Platelet rich plasma
Intervention type(s): Other
Intervention description(s): After application of platelet rich plasma after surgery, the patients have examined for infection, hematoma, pain, recurrence and the time of epithelialization of the wound.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: Platelet rich plasma(PRP); Pilonidal sinus surgery; Healing time