Curcuma Extract Beneficial for Muscle Damage
Condition: Athletes Foot
MeSH terms: Tinea Pedis
Study type: Interventional

Summary: 
      Muscle damage and inflammation is a clinical problem caused by the unimpeachable body
      adaptation of strenuous exercise through increasing free radicals. Antioxidants content in
      Curcuma is hypothesized to alleviate the free radicals. This study aimed to examine the
      effect of Curcuma extract in the form of ice cream to improve muscle damage and inflammation
      of soccer athletes caused by strenuous exercise. This study was experimental study with
      pre-post control group design. Male soccer athlete (n=20) were divided into treatment group
      (n=10) and control group (n=10). The treatment group was treated by Curcuma extract ice cream
      for 21 days. Blood samples of creatine kinase (as muscle damage marker) and IL-6 (as
      inflammation marker) were quantified.
    

Detailed description: 
      Muscle damage is a clinical problem caused by the adaptation process in strenuous exercise of
      soccer athletes which free radical is the main culprit of the damage. There is a significant
      increment of muscle damage after strength exercise using leg press. Physical exercise leads
      to inflammation process in endothelial cells of blood vessel which can be marked by releasing
      cytokine. Interleukin-6 (IL-6) is one of cytokine pro-inflammation and this marker is used as
      an indicator for inflammation of micro-trauma in muscle during strenuous exercise.

      Normally, free radical generation will be stabilized by endogenous antioxidant secretion such
      as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase; nevertheless, body
      needs exogenous antioxidant to support endogenous antioxidant as a scavenger of free radical
      in such condition.

      Muscle damage due to the strenuous exercise should be managed to avoid the pain feeling and
      subsequently decrease athlete performances. Some previous studies used herbs such as ginger
      (Zingiber officinale), ginseng (Panax quinquefolium), and Curcuma to relieve the muscle
      damage and inflammation resulting from high-intensity exercise.The Curcuma extract treatment
      to the athlete gained lack of success; therefore, supplementation to food products might use
      to increase acceptability. Ice cream is one of the products, which has a broad segment market
      and every single person regardless of age is fond of it.

      Curcumin is an antioxidant substance contained in Curcuma and it has better antioxidant
      capacity compared to the other component in Curcuma such as demetoksicurcumin and
      bisdemetoksicurcumin.Besides, curcumin has an efficient reaction with superoxide radicals as
      well as lipid antioxidants has, and the reaction leads to superoxide catalytic degradation in
      which curcumin represents as a superoxide dismutase. This study aimed to examine the Curcuma
      extract effect which has been supplemented to own-made ice cream in muscle damage and
      inflammation of soccer athletes after having strenuous exercise.
    

Intervention name(s): Ice cream
Intervention type(s): Dietary Supplement
Intervention description(s): Curcumin extract was added into ice cream
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Subjects were divided by 2 groups: control group (n=10), treated by ice cream without any Curcuma extract supplementation; and treatment group (n=10), treated by ice cream supplemented by Curcuma extract.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Curcuma extract; ice cream; inflammation; muscle damage