Changes of Macular Pigment and Parameters of Eyes After YAG Laser Treatment in Cases With Capsule Opacification
Condition: Posterior Capsule Opacification; Retinal Degeneration; Retinal Detachment; Anterior Chamber Angle Congestion; Macula Edema; Macular Pigmentation; Choroid Disease
MeSH terms: Retinal Detachment; Retinal Degeneration; Capsule Opacification; Choroid Diseases
Study type: Interventional

Summary: 
      It has been hypothesized that potential effects of laser Nd: YAG laser posterior capsulotomy
      may affect macular pigment as well as choroidal thickness, macular thickness and anterior
      chamber parameters, so it was aimed to investigate possible effects of Nd: YAG laser
      posterior capsulotomy on macular pigment optical density, choroidal thickness, macular
      thickness and anterior chamber parameters in cases with posterior capsule opacification in
      this study.
    

Detailed description: 
      This clinical trial was conducted following the principles of the Declaration of Helsinki.
      The local authorized clinical trials ethics committee approved the protocol and consent forms
      (Afyon Kocatepe University Clinical Trials Ethics Committee, 2011-KAEK-2 2017/172). Between
      2015 and 2016, 38 pseudophakic participants were enrolled in this study. After providing
      information to patients about the disease and treatment, patients predicted to show adherence
      to treatment, were enrolled in the study.

      Detailed ophthalmological examinations of all subjects were performed prior to Nd: YAG laser
      posterior capsulotomy intervention. Anterior chamber parameters of cases with PCO were
      measured Measurements of IOP, anterior chamber parameters, visual acuity, Slit-lamp,
      gonioscopy and fundus examinations, and measurements of central macular thickness (CMT),
      choroidal thicknesses (CTs), and MPOD were performed after maximal pupil dilatation.

      Proposed procedure, including risks, beneﬁts, and alternatives were discussed with all
      subjects, and all participants signed of informed consent form.

      Choroidal thicknesses were recorded as subfoveal CT (SCT), nasal CT (NCT) and temporal CT
      (TCT).

      MPOD measurements were subsequently made by using luminance differential thresholds test.
      After measurements a refractive surgery specialist carried out Nd: YAG laser posterior
      capsulotomy interventions to patients who were decided to applying Nd:YAG laser capsulotomy.

      All examinations and measurements were repeated and recorded at 1st week, 1st and 2nd month.
    

Intervention name(s): Nd: YAG laser posterior capsulotomy
Intervention type(s): Device
Intervention description(s): Nd: YAG laser posterior capsulotomy
Other intervention name(s): Tango Laserex
Intervention model: Sequential Assignment
Intervention model description: sequential self-controlled clinical trial
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Posterior Capsule Opacification; Macular Pigment Optical Density; Anterior Chamber Parameters; Nd: YAG Laser Posterior Capsulotomy; Posterior Capsulotomy; Cystoid Macular Edema; Choroidal Thickness