Titanium-prepared Platelet-rich Fibrin in Periodontal Regeneration
Condition: Platelet-Rich Fibrin
Study type: Interventional

Summary: 
      In this study, the possible effect of blood group distribution on the content of blood
      biomaterial was investigated. 64 volunteers were included in the study. Various parameters
      were evaluated. As a result, it was concluded that blood group distribution does not affect
      blood biomaterial content.
    

Detailed description: 
      The aim of this split-mouth, randomized, and controlled study was to compare open flap
      debridement (OFD) alone against OFD with autogenous Titanium-prepared platelet-rich fibrin
      (OFD+ T-PRF) combined in treating intrabony defects (IBD). Subjects were 20 systemically
      healthy patients with chronic periodontitis according to 2017 World Workshop. Bilateral
      operation sites in patients (40 sites) were randomly selected for OFD alone or OFD+ T-PRF
      combined. Clinical parameters (probing depth (PD), relative attachment level (RAL), and
      gingival marginal level(GML)), radiographic parameters (intrabone defects (IBDs) and
      periodontal bone support (PBS)), and growth factors levels (GFL) in gingival crevicular fluid
      (GCF) (platelet-derived growth factors (PDGF-BB), fibroblast growth factors (FGF-2), relative
      ratio of receptor activator nuclear factor kappa-B (RANKL)/osteoprotegerin (OPG)) were
      analyzed. The Wilcoxon signed-rank test, the Student's t-test, the two way ANOVA, and the
      Tukey post hoc test were used for statistical analysis.
    

Intervention name(s): periodontal surgical procedure (open flap debridement); periodontal surgical procedure (OFD +autogenous Titanium-prepared platelet-rich fibrin (OFD+ T-PRF))
Intervention type(s): Procedure; Procedure
Intervention description(s): All surgical procedures were performed by the second periodontist. 0.12% Chlorhexidine digluconate (CHX) rinse for intraoral antisepsis and a povidone iodine solution was used for extraoral antisepsis. After local anesthesia (2% lidocaine with epinephrine 1:100,000/ Astra, Westbrough, MA) was applied, the full thickness trapezoidal flap was raised large enough to provide adequate view of the defect area. Subgingival debridement and root planning were performed with the use of area-specific curets (Gracey curets, Hu-Friedy), and granulation tissue was removed The IBD area in the control group was closed without applying any material. Then mucoperiosteal flaps were repositioned with sutured with 4/0 monoprolene sutures.; All surgical procedures were performed by the second periodontist. 0.12% Chlorhexidine digluconate (CHX) rinse for intraoral antisepsis and a povidone iodine solution was used for extraoral antisepsis. After local anesthesia (2% lidocaine with epinephrine 1:100,000/ Astra, Westbrough, MA) was applied, the full thickness trapezoidal flap was raised large enough to provide adequate view of the defect area. Subgingival debridement and root planning were performed with the use of area-specific curets (Gracey curets, Hu-Friedy), and granulation tissue was removed (Figure 2a). The blood supply of the defect areas was taken into account. At the test site, IBDs were filled with T-PRF and T-PRF membranes were adapted over the defects both buccally and lingually, in addition to OFD (Figure 2b). Then mucoperiosteal flaps were repositioned with sutured with 4/0 monoprolene sutures.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Two different treatment modalities to treat deep periodontal intrabony defects were compared in this split-mouth, randomized, parallel and clinical study. The control group defects were treated with OFD only while the test group defects were treated with OFD supplemented with T-PRF. The same periodontal treatment procedure was applied in both groups, except for the use of T-PRF. Clinical and radiographic parameters were measured from baseline to 9 months after surgery.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: chronic periodontitis; growth factors; guided tissue regeneration; periodontal; platelet-derived growth factor; platelet-rich fibrin