bioihbjkbjnl/mcl2 huggingface dataset:
The Effect of Video and Traditional Laryngoscopy on Hemodynamic Response in Hypertensive and Normotensive Patients
Condition: Intubation; Anesthesia; Hypertension
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      During endotracheal intubation, it is known that la laryngoscopy has significant effects,
      such as tachycardia and blood pressure increase, which may be harmful, especially in those
      with cardiovascular disease. Different studies comparing laryngeal stimulation and there
      resulting hemodynamic response made with various intubation devices are available in the
      literature. The investigators planned to work with the hypothesis that endotracheal
      intubation with videolaryngoscopy would have less hemodynamic response traditional
      (Macintosh) laryngoscopy and the use of videolaryngoscopy would result in wider vision with
      less laryngeal stimulation.
    

Detailed description: 
      In this study, in a study on endotracheal intubation under general anesthesia, a routine
      preparation of endotracheal intubation using video laryngoscopy or Macintosh laryngoscopy in
      adult hypertensive and normotensive patients between 18-75 years old, form will be written
      and recorded.

      Patient age, weight, height, sex, operation, co-morbid conditions and vital findings,
      measurements used in airway evaluation, initial trial success, laryngoscope using number of
      procedures, intubation tube number will be recorded.

      Statistical analysis was performed using statistical program to compare the hemodynamic
      response of hypertensive and normotensive patients using videolaryngoscope or Macintosh
      laryngoscope
    

Intervention name(s): Macintosh laryngoscopy; C-Mac Videolaryngoscope
Intervention type(s): Device; Device
Intervention description(s): Endotracheal intubation time using the Macintosh laryngoscope; Endotracheal intubation time using the C-Mac Videolaryngoscope
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Prospective
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: laryngoscopy; videolaryngoscopy; hypertension
Mental Health Symptoms and Intimate Partner Violence
Condition: Domestic Violence; Post-Traumatic Stress Disorder; Depression
MeSH terms: Depression; Stress Disorders, Traumatic; Stress Disorders, Post-Traumatic
Study type: Observational

Summary: 
      Using a touch screen computer, the researchers are screening emergency department patients
      for intimate partner violence and mental health issues.
    

Detailed description: 
      Using a touch screen computer, the researchers are screening emergency department patients
      for intimate partner violence and mental health issues. The researchers are looking to see if
      those who participate in a computer screen and are given referral lists as well as having the
      computer printout placed on the physician clipboard, will increase physician awareness and
      recognition as well as patient use of resources compared to usual care.
    

Intervention name(s): Computer screen with community resource printout
Intervention type(s): Procedure
Intervention description(s): Patients participated in the screening process via a computer kiosk. Questions regarding IPV and mental health symptoms were asked using validated tools
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        All eligible African American female patients were approached in the ED waiting room during
        study periods. Patients participated in the screening process via a computer kiosk.
        Questions regarding IPV and mental health symptoms were asked using validated tools.
      
Keywords: Suicidality; PTSD; depression
Phase 3 Trial to Evaluate the Efficacy and Safety of COL-1620 Vaginal Progesterone Gel
Condition: Luteal Hormone Supplementation in In-vitro Fertilization; Embryo Transfer
Study type: Interventional
Phase: Phase 3

Summary: 
      The primary objective of this trial is to demonstrate the non-inferiority of the clinical
      pregnancy rate per embryo transfer to the historical standard value in in-vitro fertilization
      (IVF)/embryo transfer (ET) cycles in Japan (Japan Society of Obstetrics and Gynecology [JSOG]
      2009 registry data: 24.3 percent [%]). The secondary objectives of this trial are to assess
      the biochemical pregnancy rate per ET, pharmacokinetics, and safety of COL-1620.
    


Intervention name(s): COL-1620; Gonadotropin-releasing hormone (GnRH) analogue; Follicle-stimulating hormone (FSH); Human Chorionic Gonadotropin (hCG)
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): The subjects will be administered with COL-1620 vaginal progesterone gel (1.125 grams of progesterone gel containing 90 milligram that is 8 percent [%] gel) vaginally once daily, from the day of ovum pick-up (OPU) until Week 12.; Subjects will undergo conventional controlled ovarian stimulation (COS) therapy for in-vitro Fertilization and Embryo Transfer (IVF/ET) according to the Investigator's discretion using GnRH analogue (agonist or antagonist) preparation.; Subjects will undergo conventional COS therapy for IVF/ET according to the Investigator's discretion using FSH containing preparation.; Subjects will undergo conventional COS therapy for IVF/ET according to the Investigator's discretion using hCG preparation.
Intervention MeSH terms: Chorionic Gonadotropin; Hormones; Follicle Stimulating Hormone
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Infertility; COL-1620; progesterone gel; Fertilization in Vitro; Embryo Transfer
Study Evaluating Safety And Tolerability Of Meningococcal B Rlp2086 Vaccine In Healthy Adults
Condition: Meningitis, Meningococcal
MeSH terms: Meningitis, Meningococcal; Meningitis
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the safety and tolerability of an investigational
      meningococcal B rLP2086 vaccine in healthy adults.
    


Intervention name(s): rLP2086 vaccine or control; rLP2086 vaccine or control; rLP2086 vaccine or control; rLP2086 vaccine or control
Intervention type(s): Biological; Biological; Biological; Biological
Intervention description(s): intra-muscular vaccine (solution), 0.5 mL, 3 doses, schedule: 0, 2, 6 months; intra-muscular vaccine (solution), 0.5 mL, 3 doses, schedule: 0, 2, 6 months; intra-muscular vaccine (solution), 0.5 mL, 3 doses, schedule: 0, 2, 6 months; intra-muscular vaccine (solution), 0.5 mL, 3 doses, schedule: 0, 2, 6 months
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Study of Grass-SPIRE in Subjects With Grass Allergies and Asthma
Condition: Seasonal Allergic Rhinitis; Asthma
MeSH terms: Rhinitis; Asthma; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine whether it is safe to administer Grass-SPIRE to
      subjects suffering from both grass allergy and asthma
    


Intervention name(s): Grass-SPIRE; Placebo
Intervention type(s): Biological; Biological
Intervention description(s): Intradermal injection; Intradermal injection
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Grass; Allergy; rhinoconjunctivitis; rhinitis; asthma
The Effects of Valproic Acid on Zidovudine Glucuronidation and Pharmacokinetics in HIV-Infected Patients.
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      Primary objective: To study the pharmacokinetic interaction between zidovudine (AZT) and
      valproic acid in asymptomatic HIV-infected patients, characterizing AZT's oral
      bioavailability, plasma elimination half-time, plasma levels, and urinary excretion of AZT,
      5'-O-glucuronide (GAZT), and 3'-amino-3'-deoxythymidine (AMT). Secondary objective: To
      establish the safety of short-term administration of AZT and valproic acid in combination
      with regard to hematologic parameters and liver function in asymptomatic HIV-infected
      patients.

      Preliminary studies using human liver tissue have shown that valproic acid inhibits the
      metabolic inactivation of zidovudine (AZT), which may prolong the plasma half-life of AZT and
      thus prolong the duration of the drug's effects in the body.
    

Detailed description: 
      Preliminary studies using human liver tissue have shown that valproic acid inhibits the
      metabolic inactivation of zidovudine (AZT), which may prolong the plasma half-life of AZT and
      thus prolong the duration of the drug's effects in the body.

      Six asymptomatic HIV-infected patients are treated with AZT orally every 8 hours on days 1
      through 4, then with a single dose on day 5 (after 8 hours of fasting), followed by
      pharmacokinetic sampling. On days 6 through 9, patients receive AZT orally every 8 hours in
      combination with valproic acid (lowest dose in the first 5 patients and a higher dose in
      patients 6 and 7) orally every 8 hours. On day 10, AZT and 1 of the 2 doses of valproic acid
      are given orally as single doses, followed by pharmacokinetic sampling. AZT is continued
      alone orally every 8 hours on days 11 through 14, then resumed at the patient's usual dose
      beginning on day 15. Per 03/09/92 amendment, dosing schedule may be modified slightly to
      accommodate patients with scheduling conflicts.
    

Intervention name(s): Valproic acid; Zidovudine
Intervention type(s): Drug; Drug
Intervention MeSH terms: Zidovudine; Valproic Acid
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Valproic Acid; Zidovudine
Risk Stratification in Patients With Preserved Ejection Fraction
Condition: Myocardial Infarction
MeSH terms: Myocardial Infarction; Infarction
Study type: Observational [Patient Registry]

Summary: 
      The purpose of the study is to assess the prevalence and the prognostic value of non-invasive
      indexes and programmed ventricular stimulation for sudden cardiac death in post-myocardial
      infarction (MI) patients with left ventricular ejection fraction (LVEF)>40%.
    

Detailed description: 
      1000 asymptomatic post-MI patients>40%, at least 40 days post-MI, revascularized or without
      needing further revascularization (in any case without any evidence of ischemia) will be
      enrolled.

      The patients will be divided into two categories:

        1. Asymptomatic patients with revascularized ST-elevation MI (STEMI) (remaining stenoses in
           non culprit vessels <70%) at 40 days post-MI (when LVEF>40% will be re-assessed)

        2. Asymptomatic patients late (at any time after 40 days) after MI (initially STEMI-NSTEMI
           at discharge Q-non Q) with LVEF>40% right after a negative stress test or right after a
           negative for stenoses control coronary catheterization All patients will undergo
           non-invasive evaluation (ECG, Holter monitoring and 45-min high resolution recording).
           In case they fulfill at least one out of seven pre-specified criteria they will undergo
           programmed ventricular stimulation and implantable cardioverter-defibrillator (ICD)
           implantation (if inducible) All patients will be followed-up for 3 years for sudden
           cardiac death and its surrogate (appropriate ICD activation)
    

Intervention name(s): Programmed ventricular stimulation; ICD implantation
Intervention type(s): Procedure; Device
Intervention description(s): Programmed ventricular stimulation in high-risk patients based on non-invasive evaluation; ICD implantation in patients with induced VT in programmed ventricular stimulation
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        1000 asymptomatic post-MI patients>40%, at least 40 days post-MI, revascularized or without
        needing further revascularization (in any case without any evidence of ischemia)

        The patients will be divided into two categories:

          1. Asymptomatic patients with revascularized STEMI (remaining stenoses in non culprit
             vessels <70%) at 40 days post-MI (when LVEF>40% will be re-assessed)

          2. Asymptomatic patients late after MI (initially STEMI-NSTEMI at discharge Q-non Q) with
             LVEF>40% right after a negative stress test or right after a negative for stenoses
             control coronary catheterization
      
Keywords: Myocardial infarction; Risk stratification; Sudden cardiac death; Preserved ejection fraction; Programmed ventricular stimulation
Stem Cell Transplant From Matched Unrelated or Partially Matched Related Donors
Condition: Blood Cancer; Blood and Marrow Transplant (BMT)
MeSH terms: Hematologic Neoplasms
Study type: Interventional

Summary: 
      To evaluate the use of unrelated donors for hematopoietic cell transplantation in the
      treatment of hematologic and lymphoid malignancies.
    

Detailed description: 
      Stem Cell Transplantation from Matched Unrelated or Partially Matched Related Donors Using a
      Preparatory Regimen Consisting of Fractionated Total Body Irradiation (FTBI) and
      Cyclophosphamide (CY). To administer high dose radio-chemotherapy followed by stem cell
      transplantation from a matched unrelated donor or a partially matched related donor.
    

Intervention name(s): ablative allogeneic hematopoietic cell transplantation
Intervention type(s): Procedure
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Effectiveness and Cost-effectiveness of Motion Style Acupuncture Treatment (MSAT) for Acute Neck Pain: A Multi-center Randomized Controlled Trial
Condition: Acute Neck Pain
MeSH terms: Neck Pain
Study type: Interventional

Summary: 
      The investigators will evaluate the comparative effectiveness and safety of Motion Style
      Acupuncture Treatment (MSAT) therapy for acute neck pain compared to acupuncture.
    

Detailed description: 
      This is a multi-center, randomized, controlled, comparative effectiveness clinical trial for
      acute neck pain. Motion style acupuncture requires a part of the patient's body to move
      passively or actively while acupuncture needles are retained.
    

Intervention name(s): Motion Style Acupuncture Treatment (MSAT); Acupuncture
Intervention type(s): Other; Other
Intervention description(s): MSAT required a part of the patient's body to move passively or actively while acupuncture needles are retained.; General acupuncture
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Effects of Zero-Time Exercise (ZTEx) on Inactive Adults With Insomnia Disorder
Condition: Insomnia, Primary
MeSH terms: Sleep Initiation and Maintenance Disorders
Study type: Interventional

Summary: 
      This randomized controlled trial (RCT) with a longitudinal mixed-method process evaluation
      aims to (1) determine the effectiveness of a ZTEx intervention program, which is a
      lifestyle-integrated physical activity program, on sleep and related outcomes in inactive
      adults with insomnia disorder
    

Detailed description: 
      This randomized controlled trial (RCT) with a longitudinal mixed-method process evaluation
      aims to (1) determine the effectiveness of a ZTEx intervention program, which is a
      lifestyle-integrated physical activity program, on sleep and related outcomes in inactive
      adults with insomnia disorder; (2) identify the facilitators and barriers of ZTEx adherence,
      (3) explore the possible mechanisms of impact on ZTEx adherence and the same abovementioned
      outcomes.

      This RCT consists of two phases. In the first phase (baseline to week 8), 136 subjects will
      be randomly allocated to the ZTEx intervention or the sleep hygiene education (SHE)
      comparison group. They will receive two 2-hour ZTEx training or SHE lessons and practice ZTEx
      or follow the sleep hygiene instruction for 24 weeks. After assessment at week 8, for the
      second phase of the study (weeks 9-24), which is a proof-of-concept pilot nested in the RCT,
      subjects in the ZTEx group will be randomly divided into either an ZTEx with WhatsApp
      reminder (ZTEx+R) subgroup or an ZTEx without WhatsApp reminder (ZTEx alone) subgroup to
      evaluate the effects of WhatsApp reminders on exercise adherence and the same outcomes. Mixed
      methods process evaluation will be conducted. Post-training and post-follow-up qualitative
      focus group interviews will be conducted; facilitators, barriers, and mediators will be
      analyzed.
    

Intervention name(s): Zero Time Exercise; Sleep hygiene education
Intervention type(s): Other; Other
Intervention description(s): Zero Time Exercise encourage people to increase physical exercise by simple movements that can be done any time at any places. We offer a 2-session training course to train the subjects to do zero-time exercise.; We offer a 2-session education course to teach the subjects about sleep hygiene practice.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: insomnia
The Relationship Between Systemic Immune Inflammation Index and Disease Activity in Patients With Ankylosing Spondylitis
Condition: Ankylosing Spondylitis
MeSH terms: Spondylitis; Spondylarthritis; Spondylitis, Ankylosing; Inflammation
Study type: Observational [Patient Registry]

Summary: 
      In this study, the aim was to investigate the relationship between SII and other laboratory
      parameters with disease activity in AS patients and to discuss its usability in the follow-up
      and treatment process.
    

Detailed description: 
      This study aimed to investigate the relationship between the systemic immune inflammation
      index (SII), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and
      disease activity and functional status in patients with ankylosing spondylitis (AS). A
      cross-sectional clinical study was conducted, and a total of 90 patients diagnosed with AS
      according to the Modified New York Criteria, aged between 18 and 65, who presented to our
      outpatient clinics were included in the study. Demographic data, disease duration, age at
      symptom onset, and laboratory parameters, including platelet, neutrophil, basophil,
      eosinophil, lymphocyte counts, mean platelet volume (MPV), red blood cell distribution width
      (RDW), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), were recorded. NLR
      and PLR values were calculated. The Systemic Immune Inflammation Index (SII) was calculated
      by dividing the product of neutrophil and platelet counts by the lymphocyte count. We
      investigated all of these parameters and disease activity scores. Disease activity was
      assessed with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), spinal
      mobility with the Bath Ankylosing Spondylitis Metrology Index (BASMI), and functional status
      with the Bath Ankylosing Spondylitis Functional Index (BASFI). In addition, during the
      routine follow-ups of patients, requested blood tests were examined, and platelet,
      neutrophil, basophil, eosinophil, lymphocyte counts, mean platelet volume (MPV), RDW (red
      blood distribution width), CRP, and ESR values will be recorded. Neutrophil-lymphocyte ratio
      (NLR), platelet-lymphocyte ratio (PLR), and systemic immune inflammation index (SII) were
      calculated
    

Intervention name(s): No intervention
Intervention type(s): Other
Intervention description(s): No intervention
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Patients between the ages of 18 and 65 who have been diagnosed with Ankylosing Spondylitis
        according to the Modified New York Criteria
      
Keywords: Ankylosing spondylitis; complete blood count; inflammation
Total IgE (Immunoglobulin E) and Der p 1 (d1) Specific IgE in Induced Sputum in Patients With Allergic and Non-allergic Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Observational

Summary: 
      Asthma is a heterogeneous disease, and specifically the phenotype of non-allergic asthma is
      not yet well defined. Several studies describe this group of patients as having severe
      asthma, persistent eosinophilia and poor therapeutic response. Among the theories being
      considered is the role of local IgE. Objectives: 1) To perform a pilot test to validate the
      measurement technique and standardize the levels of total IgE and IgE specific to
      Dermatophagoides pteronyssinus (d1) in the induced sputum of asthmatic patients and healthy
      volunteers. 2) Correlate local total IgE and specific IgE levels to d1 (sputum and peripheral
      blood) in patients with allergic and non-allergic asthma. 3) Describe the clinical and
      inflammatory characteristics of patients with allergic and non-allergic asthma.
    

Detailed description: 
      Comparative cross-sectional study. It will include 32 allergic and non-allergic asthma
      patients and 10 healthy volunteers. All patients will have an induced sputum, pulmonary
      function studies, FENO (exhaled fraction of nitric oxide), total and specific IgE measurement
      at d1 (the most common perennial pneumoallergen) in blood and induced sputum, as well as a
      prick skin test with standardized allergen extracts. Measurement of total IgE and IgE for d1
      in induced sputum will be performed in the supernatant and by the ImmunoCAP (Phadia
      ThermoFisher Scientific) immunofluoroassay technique.
    

Intervention name(s): Induced Sputum
Intervention type(s): Behavioral
Intervention description(s): Total IgE and Specific IgE to Dermatophagoides pteronyssinus in Induced Sputum
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients diagnosed with asthma without evidence of allergic disease.
      
Biospecimen description: 
      Supernatant of induced sputum
    
Keywords: asthma; allergy; specific IgE