bioihbjkbjnl/mcl2 huggingface dataset:
Visual Stimulus and Eye Movement
Condition: Healthy
Study type: Observational

Summary: 
      This study is designed to understand how we see visual patterns and how these patterns lead
      to eye movements.

      Normal volunteers participating in this study face a screen on which spots or patterns of
      light are projected. They are asked to respond to the patterns by voice, eye movements or
      hand movements. Eye and lid movements are recorded in one of the following ways:

        1. Electro-oculogram < small disc electrodes taped to the skin near each eye measure the
           eye movements as the eyes change position.

        2. Infrared detector < an infrared beam is reflected off the eye and picked up by detectors
           that record the eye movements.

        3. Contact lens ring < a smooth plastic ring is placed on the white of the eye surrounding
           the cornea and eye position is measured using a magnetic coil.

      Study sessions last less than four hours.
    

Detailed description: 
      The purpose of this protocol is to study the physiology of the visuo-motor system in normal
      humans. This will be accomplished by recording eye movements and other responses (such as
      reaction time to bar press or verbal responses) to differing stimuli. The stimuli will be
      primarily visual but may include auditory or tactile stimuli.
    

Keywords: Vision; Eye Movement; Perception; Healthy Volunteer
Accuracy and Stability of a New Automatic Knee Arthrometer in Diagnosing ACL Rupture
Condition: Knee Ligament; Laxity
MeSH terms: Rupture
Study type: Observational

Summary: 
      We introduced an automatic knee arthrometer (AKA) and aimed to evaluate the repeatability and
      effectiveness thereof in diagnosing ACL rupture compared with the KT-2000.
    

Detailed description: 
      The AKA was compared to the KT-2000 at 134 N in this study, the anterior displacement and
      difference of both knees of every subject were measured. The first protocol was designed to
      evaluate examiner effect (level of experience) and contralateral-side effect (left or right
      knee) in a single healthy subject, ten times, on ten consecutive days. The second was to
      compare the stability in 20 healthy subjects, with a single experienced examiner. Third, we
      recruited 200 ACL rupture and 200 healthy subjects as contrast to compare the accuracy of the
      devices in diagnosing ACL rupture.
    

Intervention name(s): Side-to-side difference (reproducibility); Side-to-side difference (availability); Side-to-side difference (Accuracy)
Intervention type(s): Diagnostic Test; Diagnostic Test; Diagnostic Test
Intervention description(s): The experienced examiner performed tests on 20 healthy subjects; Two examiners performed the test on one healthy subject with both devices for ten consecutive days.; 200 ACL rupture and 200 healthy subjects were recruited as contrast to compare the accuracy of the devices in diagnosing ACL rupture.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        one healthy subject was tested with both devices for ten consecutive days to estimate
        examiner effect； 20 healthy subjects were tested with both devices to determine the method
        effect； 200 medicine students volunteered as healthy subjects; each with pain-free knees in
        the last three months, and without a history of knee injury； 200 patients with ACL rupture
        from our institution were also included.
Latin America Hip Fracture Mortality Study
Condition: Hip Fractures
MeSH terms: Fractures, Bone; Hip Fractures
Study type: Observational

Summary: 
      The purpose of this study is to estimate the survival proportion one year after surgery for
      intertrochanteric fracture in older adults in Latin America.
    

Detailed description: 
      This is a multi-center, prospective, observational clinical study to evaluate mortality in
      patients with surgically-treated hip fracture in Latin America, and investigate associated
      prognostic factors. Patients will be followed for 12 months.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with surgically-treated hip fracture in Latin America
      
Keywords: Hip fracture; Mortality
The Health Effects of a Blueberry Enriched Diet on Obese Children
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional

Summary: 
      The purpose of this study to determine if adding blueberries to obese children's diet will
      improve weight status and other medical testing. We would also like to determine if a larger
      research study involving blueberries is possible.
    

Detailed description: 
      Ten children aged 12 to 17 years of age who have a BMI > 95th percentile for age and who are
      patients of the Center for Better Health and Nutrition will be recruited for this 12 week
      study.

      Group 1 (Standard Therapy): Participants will be asked not to consume berries during the
      study so as not to confound the effects of eating blueberries. They will, however, be
      encouraged to consume other fruits consistent with nutrition guidelines for the Healthy
      Eating Plan (HEP: reduced glycemic load diet).

      Participants will be instructed and receive educational handout materials on implementing
      HEP. In addition participants will be introduced to the use of behavioral tools (e.g. goal
      setting, daily tracking when goals are met, and incentives provided by the family) to help
      them stay on track with HEP. Participants will be seen by the dietitian at monthly intervals
      consistent with programmatic standard of care to review adherence to HEP, use of behavioral
      tools, and change in weight status.

      Participants will be encouraged to attend group exercise classes five days per week or a
      minimum of four days per week. At the end of each exercise session, participants will receive
      a "sham smoothie" which contains no blueberries. The children will be directly observed by a
      study worker when consuming the smoothies to ensure compliance and measure how much of the
      smoothie was consumed.

      Group 2 (Blueberry Enhanced): All the features of Group 1 with the exception that the
      participants will be given a smoothie that contain 1 1/2 cups of freeze-dried whole
      blueberries crushed into a powder per serving.
    

Intervention name(s): Blueberry Smoothie; Sham Smoothie
Intervention type(s): Other; Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Obesity; Exercise; Blueberry Plant
Infant Colic Treatment With Probiotics
Condition: Infant Colic
MeSH terms: Colic
Study type: Interventional
Phase: Phase 2

Summary: 
      This study evaluates the efficacy of Bifidobacterium breve CECT7263 and the mixture B. breve
      CECT7263/Lactobacillus fermentum CECT5716 in the treatment of infant colic. Group 1 will
      receive B. breve CECT7263 (2x10E8 CFU/day) one dose per day, group 2 will receive B. breve
      CECT7263 (1x10E8 CFU/day) and L. fermentum CECT5716 (1x10E8 CFU/day) in one dose per day,
      group 3 (control group) will receive simethicone 20 mg 4 times a day.
    

Detailed description: 
      Infant colic affects between 3-40% depending on the different criteria used for diagnosis.
      Recent studies carried out in healthy infants have shown that the consumption of B. breve
      CECT7263 and L. fermentum CECT5716 during the first months of life are related to a lower
      risk to present episodes of crying characteristic of infantile colic.

      The objective of the present study is to compare the effect of B. brevis and B. brevis\L
      mixture. fermentum with respect to simethicone.

      It is a multicenter, controlled, randomized, blind, parallel-group, 4-weeks nutritional
      intervention study which will be conducted in 18 public and private hospitals and health
      centers from Spain.
    

Intervention name(s): B. breve; B. breve plus L. fermentum; Simethicone 20 MG
Intervention type(s): Dietary Supplement; Dietary Supplement; Drug
Intervention description(s): Bifidobacterium probiotic strain at 1E+08 cfu/day; Probiotic combination at 2E+08 cfu/day; Standard treatment for infant colic
Intervention MeSH terms: Simethicone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Infant colic; Bifidobacterium breve; Lactobacillus fermentum
Digital Therapeutics Smartphone Application for Methamphetamine Use Disorder
Condition: Methamphetamine Abuse
Study type: Interventional

Summary: 
      One hundred participants were recruited and randomized into a digital therapeutics (DTx)
      group (n=52) and a treatment as usual (TAU) group (n=48). The DTx group used a smartphone
      application to deliver cognitive behavioral therapy, approach bias modification, cognitive
      training, and contingency management for eight weeks. The TAU group received counseling from
      social workers and psychoterapists. Cue-induced craving, cognitive functions, PHQ-9, and
      GAD-7 were measured at baseline and post-intervention.
    


Intervention name(s): Cognitive Behavioral Therapy; Counseling; Approach Bias Modification; Cognitive Training
Intervention type(s): Behavioral; Behavioral; Behavioral; Behavioral
Intervention description(s): The cognitive behavioral therapy program consisted of eight interactive sessions, each requiring approximately 15 minutes to complete. Each ICBT session includes interactive multimedia modules (videos, pictures, and texts), the contents of which were based on the community reinforcement approach. The ICBT sessions covered the following topics: (1) introduction to digital therapeutics and CBT, (2) recognizing the triggers of craving, (3) coping with craving, (4) refusing skills/assertiveness, (5) problem-solving skills, (6) changing thoughts about drugs, (7) seemingly irrelevant decisions, and (8) HIV risks and prevention.; Counseling provided by social workers and psychotherapists on topics including work, family, stress management, and drug craving suppression.; In an ApBM session, users were instructed to swipe upward (downward) when they saw portrait (landscape) format images. A shrinking (growing) animation comes after swiping upward (downward) to simulate the visual effect of moving away (moving towards). The images were related to methamphetamine usage (methamphetamine crystals, powders, and paraphernalia) or healthy lifestyles (wealth, sports, gourmet, family activities, etc.). Each ApBM session was composed of presenting each one of the healthy lifestyle (methamphetamine) cues 12 times in landscape (portrait) and once in portrait (landscape).; The DTx application incorporated a game-based cognitive function training module for improving working memory. In this game, a matrix of squares is displayed at the center of the screen. Between 3 and 5 target symbols are randomly placed in the matrix and displayed for 2 seconds. Next, the symbols disappear, and the matrix randomly rotates. The participants were asked to click the correct locations of the target symbols within the prescribed time limit. The game becomes more difficult as the size of the matrix, the number of target symbols, and the complexity of the matrix rotation change at each level. Each cognitive function training session lasted between 3 and 5 minutes.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of GLP-1 and GIP on Insulin Secretion in Type-1 Diabetes Mellitus
Condition: Type-1 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Interventional

Summary: 
      study hypothesis: treatment with GLP-1 and/or GIP is able to potentiate the maximal
      stimulated insulin secretion even in c-peptide negative type-1 diabetic patients classified
      as having no residual beta cell function left.
    


Intervention name(s): glucagon like peptide -1; NaCl; glucose dependent insulinotropic polypeptide
Intervention type(s): Other; Other; Other
Intervention description(s): continuous infusion 1,2 pmol pr. kg pr minute at 120 minutes; infusion with NaCl for 120 minutes as placebo-arm; continuous infusion with GIP-1 (3,6pmol/kg/min) at 120 minutes.
Intervention MeSH terms: Glucagon; Gastric Inhibitory Polypeptide
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Ex Vivo Microbiological Assessment of an Anti-biofilm Catheter in Acute Dialysis Application
Condition: Hemodialysis
Study type: Interventional

Summary: 
      The clinical study aims at providing data on antimicrobial efficiency and a supposed
      additional preventive effect on catheter-related infections of a catheter with antibacterial
      surface coating in comparison to standard catheters without coating.
    

Detailed description: 
      Central venous catheters are increasingly used to provide long-term venous access, e.g. after
      failure of the primary arteriovenous fistula, and they are the first choice in case of an
      acute need for extracorporeal therapy. Microbial adhesions and biofilm formation have been
      implicated in serious infections associated with the use of indwelling catheters.

      In view of the necessity to reduce catheter-related bloodstream infections and of the
      inadequacy of currently available antimicrobially coated devices, a new antimicrobial
      catheter surface was developed.

      The clinical study described below aims at providing further data on antimicrobial efficiency
      and a supposed additional preventive effect on catheter-related infections.
    

Intervention name(s): GamCath® central venous catheter; GamCath Dolphin® Protect central venous catheter
Intervention type(s): Device; Device
Intervention description(s): Choice of central venous catheter type; Choice of central venous catheter type
Other intervention name(s): GamCath® catheter; GamCath Dolphin® Protect
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Dialysis, Extracorporeal; Dialysis, Renal; Extracorporeal Dialysis; Hemodialysis
Ultrasound- Guided Continuous Serratus Anterior Plane Block Versus Ultrasound- Guided Continuous Thoracic Paravertebral Block in Multiple Traumatic Rib Fractures.
Condition: Serratus Anterior Plane Block; Thoracic Paravertebral Block; Ultrasound; Multiple Traumatic Rib Fractures; Analgesia
MeSH terms: Fractures, Bone; Rib Fractures
Study type: Interventional

Summary: 
      The aim of this study is to compare the analgesic efficacy of ultrasound guided continuous
      SAP block and ultrasound guided continuous TPVB in patients with multiple traumatic rib
      fractures.
    


Intervention name(s): Thoracic paravertebral block; Serratus anterior plane block
Intervention type(s): Procedure; Procedure
Intervention description(s): A bolus dose of 0.25% bupivacaine (0.3 ml/kg) will be injected slowly over 3-5 minutes. At 30 minutes after injection of the loading dose, the dermatomal loss of sensation to pinprick was tested. Patients who reported pain to pinprick will be considered to have a failed block and were excluded from the study. The block will be maintained by continuous infusion of bupivacaine 0.25% at a rate of 0.1 ml/kg/h via a syringe pump. The infusion will be continued for 4 days.; A bolus of 30 ml of 0.25% bupivacaine will be injected slowly over 3-5 minutes between latissmus dorsi muscle and serratus anterior muscle (Figure 15). Then a catheter was inserted through the Tuohy needle and advanced 3cm into the space and secured in place. At 30 minutes after injection of a loading dose, the dermatomal loss of sensation to pinprick will be tested. Patients who reported pain to pinprick will be considered to have a failed block and were excluded from the study. The block will be maintained by continuous infusion of bupivacaine 0.25% at a rate of 0.1 ml/kg/h via a syringe pump. The infusion was continued for 4 days.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Determination of Pharmacokinetics of Different Curcuminoids Preparations: Pilot Study
Condition: Plasma Levels of Different Curcuminoids Preparations
Study type: Interventional

Summary: 
      This pilot study aims to investigate the pharmacokinetics of a novel curcuminoid preparation
      with suggested high bioavailability due to its solubility in water, compared to two standard
      hydrophobic formulations. The findings of this study will help the health care providers and
      community to select suitable formulation.
    

Detailed description: 
      This pilot study is the first phase that must be followed, in the second phase, by longer
      clinical trials to support the findings and investigate the role of the novel preparation on
      health.The second phase will include an assessment of the effectiveness of several doses of
      curcumin preparation on health as well as an evaluation of the tolerance and possible adverse
      effects. The latter could not be evaluated at this stage of a single dose.
    

Intervention name(s): Curcumin
Intervention type(s): Dietary Supplement
Intervention description(s): water soluble version of turmeric extract standardized to 10% curcuminoids
.
Other intervention name(s): NFH
Intervention MeSH terms: Curcumin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Other
Keywords: Curcumin H2O, Tumeric, piperine
Acute Effects of an Herbal Tea on Immune Surveillance and Activation.
Condition: Active Immune Response
Study type: Interventional

Summary: 
      A small cross-over trial on 24 people involving an herbal tea blend to test whether consuming
      1 cup of tea triggers changes in the numbers of natural killer cells in the blood circulation
      as evidence of immune cell trafficking within 2 hours.
    

Detailed description: 
      A randomized, cross-over, controlled study design will be used to evaluate the effects of
      consumption of 1 cup of an herbal tea blend to consumption of the same volume of warm water.
      The study is of 3 weeks' duration, with evaluation of the herbal tea blend versus warm water
      at week 1 and week 2 with a one week washout between visits. On each visit, a baseline blood
      draw is performed, followed by consuming of the herbal tea blend or warm water. Blood draws
      are performed at 1 and 2 hours after consumption.
    

Intervention name(s): Herbal tea blend; Warm water
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 1 cup of freshly brewed tea from an herbal tea blend.; 1 cup of warm water
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: The study uses a randomized double-blinded controlled cross-over study design.
Masking: None (Open Label)
Primary purpose: Basic Science
Relative Bioavailability Study in Healthy Subjects to Evaluate the Pharmacokinetics of HTL0009936 After One Dose of Prototype Formulation
Condition: Alzheimer's Disease
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to find a modified release oral tablet formulation for this
      drug, which will be safe and well tolerated.
    

Detailed description: 
      The aim of the study is to develop a modified release oral tablet formulation that maintains
      plasma concentrations within the target therapeutic range, and is safe and tolerable.
    

Intervention name(s): HTL0009936 modified release; HTL0009936 immediate release
Intervention type(s): Drug; Drug
Intervention description(s): HTL0009936 modified release; HTL0009936 immediate release
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Efficacy Study of an Olfactory Stimulation Program for the Recuperation of Autobiographical Memories in Anorexia
Condition: Anorexic
MeSH terms: Anorexia
Study type: Interventional

Summary: 
      The purpose of this study is to estimate the impact of an olfactive stimulation, in relaxing
      environment, on the access at the autobiographical memories in anorexic patients.
    


Intervention name(s): olfactory stimulation program
Intervention type(s): Behavioral
Intervention description(s): 8 individual sessions of olfactory stimulation at the rate of 2 sessions per week. 3 semi-directed interviews will be help (one at the beginning of the trial, the second 5 weeks later and the third at 6 month).
For each session, patients have to smell two different odors (previously selected from a panel presented to the patient during first visits) and then they are invited to evoke memories and feelings related to each odor.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: anorexic; olfactory stimulation; autobiographical memories recovery
A Study of LY3457263 in Healthy Participants and Participants With Type 2 Diabetes
Condition: Healthy; Type 2 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      The main purpose of this study is to investigate the safety and tolerability of the study
      drug LY3457263 in healthy participants and participants with type 2 diabetes. Blood tests
      will be performed to investigate how the body processes the study drug and how the study drug
      affects the body. The study has two parts (part A and B). Each part will last up to 10 weeks
      and may include up to either 13 (part A) or 19 (part B) visits.
    


Intervention name(s): LY3457263; Dulaglutide; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Administered SC; Administered SC; Administered SC
Other intervention name(s): LY2189265
Intervention MeSH terms: Dulaglutide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science