bioihbjkbjnl/mcl2 huggingface dataset:
ERCP Plus Laparoscopic Cholecystectomy Versus Laparoscopic Common Bile Duct Exploration and Cholecystectomy
Condition: Common Bile Duct Calculi
MeSH terms: Gallstones; Calculi
Study type: Interventional

Summary: 
      Around 10-18% of patients undergoing cholecystectomy for gallstones have common bile duct
      (CBD) stones. Currently, various procedures for the treatment of
      cholecystocholedocholithiasis are available including open cholecystectomy plus open common
      bile duct exploration (OC+OCBDE), laparoscopic cholecystectomy plus laparoscopic common bile
      duct exploration (LC+LCBDE), may be trans-cystic or trans-choledochal, and laparoscopic
      cholecystectomy plus endoscopic retrograde cholangiopancreatography (LC+ERCP), which may be
      performed pre, at, or after LC.
    

Detailed description: 
      Around 10-18% of patients undergoing cholecystectomy for gallstones have common bile duct
      (CBD) stones. Currently, various procedures for the treatment of
      cholecystocholedocholithiasis are available including open cholecystectomy plus open common
      bile duct exploration (OC+OCBDE), laparoscopic cholecystectomy plus laparoscopic common bile
      duct exploration (LC+LCBDE), may be trans-cystic or trans-choledochal, and laparoscopic
      cholecystectomy plus endoscopic retrograde cholangiopancreatography (LC+ERCP), which may be
      performed pre, at, or after LC.

      Single-session treatment of gallbladder and CBD stones is safe, efficient, shortens hospital
      stay, and is less expensive than staged procedures.

      Although there is some evidence suggesting that LCBDE may be associated with a lower rate of
      retained stones compared with ERCP, previous studies comparing LCBDE with ERCP and stone
      extraction have collectively failed to demonstrate the superiority of one approach over the
      other.
    

Intervention name(s): Endoscopic retrograde cholangiopancreatography plus laparoscopic cholecystectomy; aparoscopic common bile duct exploration and laparoscopic cholecystectomy
Intervention type(s): Procedure; Procedure
Intervention description(s): laparoscopic removal of gallbladder and endoscopic extraction of common bile duct stones; laparoscopic removal of gallbladder and laparoscopic extraction of common bile duct stones
Other intervention name(s): ERCP plus LC; LCBDE plus LC
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Endoscopic retrograde cholangiopancreatography; laparoscopic common bile duct exploration; Laparoscopic cholecystectomy; single operator; cholecystocholedocholithiasis
Effect of Physical Therapy Exercises on Cardiorespiratory Fitness Level in COVID19 Patients After Recovery.
Condition: Covid19
MeSH terms: COVID-19
Study type: Interventional

Summary: 
      In some patients, lung function declined by about 20 to 30% after recovery. Computer
      tomography of COVID-19 patients revealed a ground glass opacity in both lungs. We will
      measure the Cardiorespiratory fitness according to American College of Sports medicine
      guidline and provide physiotherapy exercise to the patients to measure the improvement.
    

Detailed description: 
      In December 2019, the first reports emerged of a novel severe acute respiratory syndrome
      (SARS) coronavirus 2 (SARS-CoV-2) in Wuhan, China. The virus, which causes atypical pneumonia
      progressing to acute lung injury and acute respiratory distress syndrome (ARDS) in some
      individuals, was named COVID-19. The burden of fibrotic lung disease following SARS-CoV-2
      infection is likely to be high; therefore, given the scale of the pandemic, the global burden
      of fibrotic lung disease will probably increase considerably. The aim of this study is to
      check the cardiorespiratory fitness level and the effect of Physical therapy intervention to
      improve the Cardiorespiratory fitness level in patients recovered from COVID-19. Quality of
      life has also been affected due to COVID19 due to decreased Cardiorespiratory fitness level,
      and this study also aims to improve the quality of life of people recovered from COVID19.
    

Intervention name(s): Physical Exercises
Intervention type(s): Other
Intervention description(s): Aerobic Training and Breathing Exercises.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Cardiorespiratory fitness
IVF Hyper-responders: Oocyte Vitrification Compared With Embryo Freezing
Condition: Infertility
MeSH terms: Infertility
Study type: Interventional

Summary: 
      The chances to achieve pregnancy after retrieving >15 oocytes are not good, probably because
      of bad effect on the endometrium (uterine inner lining). Therefore, in most such cases the
      investigators prefer to freeze all embryos, and transfer in a thaw cycle. With the
      introduction of oocyte vitrification (very fast cooling) technology, a new option emerged: to
      freeze un-fertilized eggs, to be fertilized and used later in a thaw cycle.

      The purpose of this study is to compare the outcome of these two approaches.
    


Intervention name(s): oocyte vitrification; embryo freezing
Intervention type(s): Procedure; Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Luteal Support and Intrauterine Insemination (IUI) With Clomiphene Citrate
Condition: Infertility
MeSH terms: Infertility
Study type: Interventional

Summary: 
      The purpose of this study is to assess the effect of luteal phase supplement (LPS) on
      pregnancy rate in IUI cycles stimulated with clomiphene citrate.
    


Intervention name(s): micronized progesterone
Intervention type(s): Drug
Intervention description(s): 600mg in 3 separate doses per day
Other intervention name(s): utrogestan
Intervention MeSH terms: Progesterone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: IUI; clomiphene citrate; utrogestan
Relationship Between Eye Pressure and Ganglion Cell Function in Eyes Receiving Latanoprost Versus Placebo
Condition: Glaucoma
MeSH terms: Ganglion Cysts; Glaucoma
Study type: Observational

Summary: 
      The purpose of this investigation is to evaluate the relationship between IOP fluctuation,
      RGC dysfunction, and optic nerve and retinal nerve fiber layer (RNFL) thickness changes in
      patients with glaucoma and ocular hypertension receiving latanoprost 0.005% versus placebo.
    

Detailed description: 
      It has been hypothesized that intraocular (IOP) variability is an independent risk factor for
      the progression of glaucoma. IOP variability includes 24 hour IOP fluctuation during the
      waking period (diurnal fluctuation) and sleep period (nocturnal fluctuation) as well as
      longitudinal IOP variability measured in the diurnal period over the course of multiple
      office visits.

      Latanoprost has been clinically used to lower eye pressure in glaucoma and ocular
      hypertension for almost 10 years. Latanoprost 0.005% has been demonstrated to provide
      superior ocular hypotensive efficacy compared with timolol 0.5% in pivotal phase 3 clinical
      trials (Alm et al. 1995; Camras 1996).

      The Pattern Electroretinogram (PERG) is a non-invasive technology that objectively measures
      the retinal ganglion cell (RGC) function (Porciatti and Ventura 2004). A recent study has
      demonstrated that the RGC function can be improved following IOP reduction in glaucomatous
      eyes with early visual field defects (Ventura and Porciatti 2005).

      The purpose of this investigation is to evaluate the relationship between IOP fluctuation,
      RGC dysfunction, and optic nerve and retinal nerve fiber layer (RNFL) thickness changes in
      patients with glaucoma and ocular hypertension receiving latanoprost 0.005% versus placebo.
    

Intervention name(s): latanoprost 0.005%; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Active comparator; Placebo comparator
Other intervention name(s): Xalatan; Inactive tear drops
Intervention MeSH terms: Latanoprost
Observational model: Case-Crossover
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with primary open angle glaucoma or ocular hypertension from the Glaucoma Clinic
        at Bascom Palmer Eye Institute- Palm Beach Office.
      
Keywords: Glaucoma; intraocular pressure; latanoprost; retinal ganglion cell; pattern electroretinogram
Evaluating Parent Delivered Interventions for Children With Autism
Condition: Autistic Disorder; Developmental Disabilities
MeSH terms: Autistic Disorder; Developmental Disabilities
Study type: Interventional

Summary: 
      The investigators will assess the efficacy of parent delivered interventions in the treatment
      of social and communication deficits in children with autism. By collecting information about
      parent and child functioning before and after intervention, the investigators will be able to
      determine whether the intervention is effective in improving child social communication and
      reducing parent stress.
    


Intervention name(s): Pivotal Response Training (PRT); PACE Therapy; PACE and PRT Hybrid
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): The behaviorally-based intervention is a treatment model that uses the principles of Applied Behavior Analysis (Koegel, Openden, Fredeen, & Koegel, 2006) to increase children's adaptive behaviors and decrease maladaptive behaviors.; The developmentally based intervention is grounded in a development theory, that focuses on child-directed interactions with warm and caring individuals that aid in acquiring missed developmental and functional milestones.; The hybrid based treatment has an eclectic approach that incorporates both systematic (behaviorally-based) and affect-based learning (developmentally-based)that focuses on increasing children's skill development (http://www.pacificautism.org).
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Short-term Effects of Exercise Program Versus Electropuncture in Patients With Chronic Non-specific Low Back Pain: A Randomized Clinical Trial.
Condition: Low Back Pain; Exercise Program; Electroacupuncture
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      This study evaluate the effectiveness that exists when performing a treatment based on a
      table of exercises for strengthening the lumbar muscles versus a treatment based on
      electropuncture in patients with chronic low back pain.
    

Detailed description: 
      Low back pain has a high prevalence in all European countries, appearing as the main cause of
      activity limitation in people under 45 years of age. It has got a high recurrence, which
      decreases the activities of daily life, facilitates the focus of attention to pain and
      increases the fear of movement, with the consequent muscular atrophy. A serie cases will be
      conducted comparing a a table of exercises versus electropuncture.

      Objective: Evaluate the effectiveness that exists when performing a tratment based on a table
      of exercises for strengthening the lumbar muscles versus a treatment based on
      electropuncture.

      Methods: A sample of 12 subjects with chronic low back pain will be assigned to an exercise
      program or dry electropuncture treatment (EPS), during 4 weeks (2 sessions/week). The
      measurement variables selected for the study were the followings: Straight Leg Raise,
      Vasalva, Gaesslen test, algometry (pressure pain threshold), goniometry (measurement of the
      range of motion), Scale of disability for low back pain of Oswestry, Beck's Depression
      Inventory (BDI), Visual Analogue Scale (EVA), Mcquade's Test and the Roland-Morrys'
      Questionnaire, developing a pre-treatment and post-treatment assessment.
    

Intervention name(s): Percutaneous electrostimulation treatment (EPS); Exercise program
Intervention type(s): Other; Other
Intervention description(s): Apply dry needles in a tight band of some of the muscles that most affect the appearance of low back pain, such as: paravertebral, lumbar quadrate, gluteus medius and pyramidal, and administer analgesic microcurrents.; It will be consist in a program of lumbo-pelvic stabilization exercises and strengthening of CORE.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: chronic low back pain; physical therapy; randomized clinical trial; exercise program
Comparison of Remimazolam and Dexmedetomidine for Intraoperative Sedation
Condition: Orthopedic Disorder
MeSH terms: Musculoskeletal Diseases
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to compare the sedation efficacy of dexmedetomidine and
      remimazolam for intraoperative sedation during regional block.
    


Intervention name(s): Remimazolam; Dexmedetomidine
Intervention type(s): Drug; Drug
Intervention description(s): 0.075 mg/kg Remimazolam bolus infusion for 1 min, then 0.5~1.0 mg/kg/h continuous infusion; 1 mcg/kg Dexmedetomidine infusion for 10 min, then 0.2~0.7 mcg/kg/h continuous infusion
Intervention MeSH terms: Dexmedetomidine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
A Telephone Intervention to Improve Participation in a Screening Program.
Condition: Colorectal Cancer; Colorectal Neoplasms
MeSH terms: Colorectal Neoplasms
Study type: Interventional

Summary: 
      Objective: To assess the effectiveness of a brief telephone intervention added to an post
      invitation letter in the participation rate to a colorectal cancer screening program.

      Methods: Randomized controlled trial. This study is framed inside the colorectal cancer
      screening program of Catalonia, concretely in the region of Vallès Occidental. This program
      is directed to men and women from 50 to 69 years. The screening test used is the fecal
      immunological test (FIT) that is offered every 2 years. If the screening test is positive, a
      colonoscopy with sedation is offered as a diagnostic test.
    


Intervention name(s): Phone call; Invitation letter
Intervention type(s): Other; Other
Intervention description(s): A brief telephone intervention at the same time of sending the invitation letter plus the habitual invitation process used in the screening program (described in control group). Each phone call will last approximately 5 minutes.
Calls will be made by the administrative staff of the Screening Technical Office, which is experienced in telephone attention.; The habitual invitation strategy used in the screening program . Three letters are send by post: 1- An invitation letter plus an information leaflet and a list of pharmacies in which people can obtain the screening test. 2- A reminder letter for those who have not participated after 5 weeks of sending the first letter. 3- A second reminder letter for those who have collected the kit in the pharmacy but have not returned it with the sample
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Screening
Keywords: screening; early detection; participation
Efficacy of Synchronous and Asynchronous Telerehabilitation in COVID-19 Discharges
Condition: COVID-19; Telerehabilitation
MeSH terms: COVID-19
Study type: Interventional

Summary: 
      Investigators aimed to evaluate the effectiveness of exercise programs given by synchronous
      and asynchronous telerehabilitation methods in patients after discharge from COVID-19.
    

Detailed description: 
      Fifty seven participants will be enrolled. Participants will be randomly divided into 3
      groups.

      For this purpose, patients will be recruited at the time of discharge from the hospital and
      two experimental groups with the same physical therapy and educational program will be
      carried out. participants in the control group will only educational program. Participants in
      experimental groups will be followed using videoconference interviews from synchronous
      telerehabilitation methods and mobile application from asynchronous telerehabilitation
      methods at home. These participants will be given an 8-week exercise program. The exercise
      program will consist of physical exercises (aerobic and strength exercises) along with
      breathing exercises and the patients will be evaluated before and after the treatment.

      After treatment programs, the functional capacity, performance, and hemodynamic parameters of
      the participants will be evaluated. Quality of life, physical activity level,
      anxiety-depression, and fatigue severity will also be evaluated with questionnaires.
    

Intervention name(s): Synchronous telerehabilitation programme; Asynchronous telerehabilitation programme
Intervention type(s): Other; Other
Intervention description(s): Exercise program and educational program; Exercise program educational program
Other intervention name(s): Video conference; Mobil application
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized Controlled Study
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: COVID-19; Telerehabilitation; Exercise program; Breathing exercises
A Prospective Study of Human Bone Adaptation Using a Novel in Vivo Loading Model
Condition: Bone Loss
Study type: Interventional

Summary: 
      The purpose of this study is to understand how different types of mechanical forces can
      influence bone adaptation (and make bones stronger, potentially). Forces acting on bones
      cause mechanical strain. In small animals, strain magnitude and rate have been shown to
      stimulate bone adaptation. This study is designed to test the degree to which strain
      magnitude and rate govern bone adaptation in healthy adult women.
    

Detailed description: 
      The study consists of three Aims:

      Aim 1: compare the effect on bone structure of mechanical signals with low strain magnitude,
      high strain magnitude, and control groups over a 12-month prospective period.

      Aim 2. Compare the effect on bone structure of mechanical signals with low strain rate, high
      strain rate, and control groups over a 12-month prospective period.

      Aim 3: Examine the effect of withdrawing mechanical signals, by measuring bone structure
      during the 12 months after the intervention is withdrawn.

      The intervention is a voluntary forearm compression task, consisting of leaning onto the palm
      of the hand to produce a target force.

      The primary outcome measure is change in distal radius bone mineral content (BMC).
    

Intervention name(s): voluntary forearm loading task
Intervention type(s): Other
Intervention description(s): voluntary task, consisting of leaning onto the palm of the hand until a target force is reached. Each loading bout consists of 100 loading cycles, which takes approximately 2 minutes to complete. The task is performed 4 times per week during the intervention period.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Basic Science
Keywords: bone; adaptation; mechanical stimuli; women; peak bone mass
Upright Versus Supine Exercise Testing in Fontan-palliated Patients
Condition: Fontan Palliation
Study type: Observational

Summary: 
      Fontan-palliated patients comprise an interesting group of single-ventricle patients who are
      dependent upon passive return of blood from the body to the lungs. Systemic venous pressures
      are therefore quite elevated, and one study demonstrated that venous capacitance was
      diminished. In addition, these patients have markedly diminished aerobic capacity (Max VO2).
      Although one recent study demonstrated that Fontan patients can increase their Max VO2
      through diligent cardiac rehabilitation, their ultimate results were still well below
      average.

      It has previously been described that normal, healthy subjects have decreased exercise
      performance in a supine vs upright position. However, due to high venous pressures and the
      need for systemic venous return to overcome gravity in order to perfuse the lungs, one might
      hypothesize that Fontan patients would have increased exercise performance in a supine vs
      upright position. The investigators are interested in studying this hypothesis.
    


Intervention name(s): Supine positioning; Upright positioning
Intervention type(s): Other; Other
Intervention description(s): Subjects underwent exercise testing on a stationary bicycle in the supine position; Subjects underwent exercise testing on a stationary bicycle in the upright position
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Fontan-palliated patients aged 8-30 will be recruited for this study. Eligible patients
        will be identified from the cardiology and surgery database here. Patients will be
        contacted by phone and/or formal letter informing them of the study. If their primary
        cardiologist is not in our group, a courtesy call will be made or letter sent. Age and
        gender matched healthy controls will be sought as well through local recruitment (schools,
        university campus, local community postings).
      
Keywords: Supine; Upright
The Experience of the Child With Cancer When Port à Cath Needle : Child's Speech
Condition: Pediatric Oncology
MeSH terms: Neoplasms
Study type: Observational

Summary: 
      This qualitative research refers to the descriptive phenomenological method of Hurssel which
      allows an analysis of the experience and an understanding of the phenomenon. Semi-structured
      interviews are carried out with 10 children followed for cancer in 3 pediatric
      hemato-oncology departments. The children interviewed are aged 6 to 12 and can be with their
      parents. A thematic analysis approach is used to analyze the data of this research.
    


Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Children aged 6 to 12 with cancer and who have weekly care, requiring port-a-cath needle
        placement.
      
Keywords: Pediatrics; Cancer; Care; Experience; Port-a-cath
Outcomes in CF Patients Accessing Their Registry Health Records
Condition: Cystic Fibrosis
MeSH terms: Cystic Fibrosis; Fibrosis
Study type: Interventional

Summary: 
      A multifactorial, parallel group, randomised control study in cystic fibrosis (CF) patients
      aged 13-30 years over an 18 month period. Patients will be offered read-only access to their
      CF registry electronic health record (CF View), or educational videos on CF (videos), or
      videos and CF View, or usual standard of care. The study aims are to examine the effect of
      patient access to C View on a range of clinical outcomes, health service usage, health
      literacy and patient reported outcomes.
    


Intervention name(s): CFView; CF educational videos
Intervention type(s): Other; Other
Intervention description(s): Registry patient portal; CF educational videos
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care