bioihbjkbjnl/mcl2 huggingface dataset:
Uses of Gamma Irradiated Amniotic Membrane as an Alternative Method in Psoriasis Treatment
Condition: Psoriasis
MeSH terms: Psoriasis
Study type: Interventional

Summary: 
      Using of human amniotic membrane extra-cellular matrix as a topical treatment for improving
      Psoriasis Area and Severity Index (PASI).
    

Detailed description: 
      Human amniotic membrane extra-cellular matrix was purchased from National center for
      radiation research and technology, Egypt, under commercial name REGE pro gel.
    

Intervention name(s): REGE pro
Intervention type(s): Combination Product
Intervention description(s): REGE pro is a patch of human amniotic membrane sterilized by gamma radiation
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Amniotic membrane; Psoriasis; Treatment
Controlled Study to Assess the Efficacy and Safety of S-Ibuprofen Topical Gel 5% (AP0302) in the Treatment of DOMS
Condition: Pain, Acute
MeSH terms: Acute Pain
Study type: Interventional
Phase: Phase 2

Summary: 
      Phase 2 study designed to evaluated analgesic efficacy and safety of S-Ibuprofen Topical Gel
      5%
    

Detailed description: 
      The purpose of this randomized, double-blind study is to evaluate the efficacy and safety of
      S-Ibuprofen Topical Gel 5% in reducing pain/soreness associated with delayed onset muscle
      soreness (DOMS).
    

Intervention name(s): S-Ibuprofen; Vehicle
Intervention type(s): Drug; Drug
Intervention description(s): Topical Gel 5%; Vehicle Gel
Intervention MeSH terms: Ibuprofen
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Sevoflurane in Electroconvulsive Therapy
Condition: ECT; Anesthesia
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of the study was to investigate the effects of different doses of sevoflurane
      used in electroconvulsive therapy (ECT) on duration of seizure, hemodynamic response and
      recovery profiles
    

Detailed description: 
      Motor (EMG) and electroencephalography seizure duration (EEG), heart rate (HR) and mean
      arterial pressure (MAP) values, and recovery times were recorded.
    

Intervention name(s): sevorane
Intervention type(s): Drug
Intervention description(s): Sevorane 4% Sevorane 7%
Other intervention name(s): Sevoflurane
Intervention MeSH terms: Sevoflurane
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: electroconvulsive therapy; seizures; sevoflurane
Effects of Naltrexone on Nicotine Reinforcement
Condition: Tobacco Dependence
MeSH terms: Tobacco Use Disorder
Study type: Interventional
Phase: Phase 2

Summary: 
      Despite preclinical evidence supporting the role of the endogenous opioid system in the
      reinforcing effects of nicotine, the efficacy of the opioid antagonist naltrexone (NTX) as a
      tobacco dependence treatment remains unresolved. Research is needed to identify those smokers
      for whom NTX will have the strongest beneficial effects on smoking behavior.

      The research bridges existing knowledge of genetic, pharmacologic, and behavioral responses
      to nicotine, and translates this knowledge to treatment for tobacco dependence. The immediate
      goal was to test whether genetic variation in the mu-opioid receptor gene predicts the
      effects of naltrexone (NTX) on nicotine reinforcement.
    

Detailed description: 
      The study was a within-subject double-blind study of the effects of naltrexone versus placebo
      on the reinforcing value of nicotine, using a validated cigarette choice paradigm. A key
      question was whether smokers differ in their responses based on the mu opioid receptor gene
      (OPRM1) Asn40Asp (A118G) variant.

      Following informed consent, 64 smokers were enrolled in the study. Of these, 60 completed two
      4-day study phases interspersed with a 5-7 day washout phase. Baseline statistics are
      provided for the 64 smokers who enrolled.

      Each 4-day study phase included a 3-day drug run-up and monitoring phase, then on the 4th day
      participants came to our Biobehavioral Lab (BBL) where they took their final 50mg of study
      medication and completed a cigarette choice paradigm. Following a washout phase, the 4-day
      sequence will be repeated with the alternative study medication. The order of study
      medication was randomized and counterbalanced between subjects.
    

Intervention name(s): Naltrexone; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): All participants took naltrexone during one of the two 4-day study medication periods. Both 4-day study medication periods were randomized and counterbalanced between naltrexone and placebo; all study medication periods were separated by a 5-7 day washout period.
Dosing of the naltrexone was the same for all participants: Day 1: 12.5mg, Day 2: 25mg, Days 3 and 4: 50mg.; All participants took a placebo (sugar pill) during one of the two 4-day study medication periods. Both 4-day study medication periods were randomized and counterbalanced between naltrexone and placebo.
Placebo capsules matched the naltrexone in color, weight and inactive ingredients. The only difference the lack of active naltrexone in each capsule.
Other intervention name(s): Revia or Trexan; Sugar pill; inactive medication
Intervention MeSH terms: Naltrexone
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Keywords: within-subjects, crossover, laboratory study; Naltrexone vs. Placebo
ESPB and ACB in Knee Arthroplasty
Condition: Post Operative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      Total knee arthroplasty surgery is preferred in the treatment of osteoarthritis and causes
      severe postoperative pain. In this study, we aimed to investigate the effects of lumbar
      erector spina plan block and adductor canal block on postoperative pain and quadriceps muscle
      strength in patients who underwent total knee arthroplasty with spinal anesthesia.
    

Detailed description: 
      In a prospective, randomized study; Medeniyet University Faculty of Medicine Göztepe Prof.
      Dr. Forty patients who underwent total knee arthroplasty surgery at Süleyman Yalçın City
      Hospital were divided into two groups. After the surgery was completed, erector spina plane
      block was applied to Group E (n=20) patients with 20 ml of 0.25% bupivacaine from the
      operated side L3-L4 level, while in Group A (n=20) patients, in the area where the sartorius
      muscle crosses the adductor magnus muscle, it was lateral to the superficial femoral artery.
      Adductor canal block was applied to the adductor canal with 20 ml of 0.5% bupivacaine. All
      patients were administered 1 gr paracetamol and 75 mg diclofenac sodium when their pain
      started in the orthopedic ward. Numerical pain score and quadriceps muscle strength were
      evaluated during the 48-hour follow-up of the patients. When the pain score was 4 and above,
      50 mg pethidine hydrochloride was administered.
    

Intervention name(s): Erector Spinae Plane Block; Adductor Canal Block
Intervention type(s): Procedure; Procedure
Intervention description(s): After the necessary asepsis and antisepsis procedures, the linear ultrasound probe was placed parasagittally 2-3 cm lateral to the spinous process at the L3 or L4 level and the transverse process was visualized. The peripheral block needle (85 mm B Braun Stimuplex A) was advanced in plane up to the transverse process and 10 ml 0.5% bupivacaine hydrochloride 10 ml 0.9% isotonic NaCl mixture was applied on the erector spina muscle.; After the necessary asepsis and antisepsis procedures, the linear ultrasound probe was placed in the middle between the medial condyle and the SIAS, and the superficial femoral artery (FSA) was visualized under the sartorius muscle. By following the FSA distally, the point where the sartorius muscle crosses the adductor magnus muscle, which is the beginning of the adductor canal, was found and the saphenous nerve was visualized hyperechoic in the anterolateral aspect of the FSA. 20 cc 0.5% bupivacaine hydrochloride was applied
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Erector Plane Block Adductor Canal Block
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Erector Spinae Plane Block; Adductor Canal Block; Total Knee Arthroplasty
Cortical Priming to Optimize Gait Rehabilitation Post Stroke
Condition: Stroke
MeSH terms: Stroke
Study type: Interventional

Summary: 
      Over four million stroke survivors currently living in the United States are unable to walk
      independently in the community. To increase the effectiveness of gait rehabilitation, it is
      critical to develop therapies that are based on an understanding of brain adaptations that
      occur after stroke. This project will be the first step towards the development of a novel
      therapeutic approach using brain stimulation to increase walking capacity in stroke survivors
      and understand the neural mechanisms that are associated with impairment and functional
      recovery.
    


Intervention name(s): tDCS; AMT; Treadmill training
Intervention type(s): Other; Other; Behavioral
Intervention description(s): 1 mA of tDCS; Ankle motor training; High intensity treadmill training
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Gait; Brain stimulation; tDCS; Walking
Efficacy of Different Oral Rehydration Solutions on the Hydration Status of Healthy Males
Condition: Fluid Retention; Beverage Hydration Index; Hydration Status
Study type: Interventional

Summary: 
      Dehydration lowers both physical and mental performance if it is severe enough. Performance
      declines are more pronounced in hot conditions or after prolonged strenuous activity such as
      exercise. Most individuals drink less than their sweat losses during activity, while some
      individuals overdrink and develop a sodium deficiency. Water and electrolyte balance must be
      restored as part of the recovery process after any activity that causes sweating. Plain water
      causes a decrease in plasma sodium concentration and osmolality, which reduces the desire to
      drink and increases urine production. Unless the volume ingested exceeds the loss,
      individuals are in net negative fluid balance throughout the recovery period due to urinary
      losses. When sodium and potassium are added to rehydration fluids, urine production is
      reduced in the hours following rehydration. Rehydration is only possible if a volume of fluid
      equal to or greater than the amount lost through sweat is consumed, together with adequate
      electrolytes. The two test products for this study, are novel hydration beverage formulas.
      They are an electrolyte drink mixture with five essential vitamins and three times more
      electrolytes than typical sports beverages. The test products create an osmotic force that
      permits water to be supplied to the bloodstream sooner in the digestive system by using a
      specific ratio of sodium, glucose, and potassium. This randomized, placebo-controlled,
      semi-blind, crossover study will evaluate the effects of the test products on rehydration in
      healthy adults.
    


Intervention name(s): Test product 1; Test product 2; Placebo
Intervention type(s): Other; Other; Other
Intervention description(s): Participants will receive TP1 during one experimental visit.; Participants will receive TP2 during one experimental visit.; Participants will receive placebo during one experimental visit.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
Quetiapine Fumarate (Seroquel) for the Treatment of Alcohol Dependence.
Condition: Alcoholism
MeSH terms: Alcoholism
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to determine whether seroquel is effective in the treatment of
      type A and type B alcohol dependence.
    

Detailed description: 
      The purpose of this study is to obtain preliminary data regarding the safety, efficacy and
      tolerability of quetiapine [Seroquel (SQL)] in treating Type A vs B alcohol dependent
      outpatients seeking treatment.
    

Intervention name(s): Seroquel; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 400mg/day quetiapine; 400mg/day placebo
Intervention MeSH terms: Quetiapine Fumarate
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: alcohol dependence
Comparison of ISQ in Implants Placed in Antral Area on Native Bone vs Regenerated Bone
Condition: Implant Site Reaction
Study type: Observational

Summary: 
      Compare ISQ values of implants placed in antral area in native bone vs regenerated bone with
      a follow-up at 3 months to compare values changes.
    

Detailed description: 
      The stability of dental implants is influenced by the type of bone in which the implant is
      placed. Native bone tends to provide better initial stability due to its density and quality,
      while regenerated bone, it is logical to think that it may present less stability due to the
      quality of the generated bone and the presence of defects in the treated area.

      In this study it has been observed that after 3 months more stability is observed in the
      antral area, measured in ISQ resonance frequency in implants on regenerated bone, which
      surprises us and this result is explained in detail in said study.
    

Intervention name(s): sinus lift; resonance frequency analysis
Intervention type(s): Procedure; Device
Intervention description(s): Implant placement on grafted sinus vs antral autogenous bone; analysis of the ISQ evolution and its changes after 3 months of placing the implant in native or regenerated bone, always in the antral area
Other intervention name(s): alveolar preservation; ISQ
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The study group is made up of adult patients from the UEM Dental University Clinic, from
        September 2017 to September 2018, who attended the Master's Degree in Advanced Oral
        Implantology and who were informed of the study and signed the informed consent.
      
Biospecimen description: 
      we performed an ostell mesuarement on dental implants
    
Keywords: Implant placement; native bone; regenerated bone; resonance frequency analysis; ISQ value; Ostell
Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation
Condition: Out-of-Hospital Cardiac Arrest
MeSH terms: Heart Arrest; Out-of-Hospital Cardiac Arrest
Study type: Interventional

Summary: 
      The COMACARE trial is a pilot multicenter randomized trial to assess the feasibility and
      effect on brain injury markers of targeting low or high normal arterial oxygen tension
      (PaO2), arterial carbon dioxide tension (PaCO2) and mean arterial pressure (MAP) in comatose,
      mechanically ventilated patients after out-of-hospital cardiac arrest. Using factorial
      design, participants are randomized at admission to intensive care unit to one of eight
      groups targeting either low or high normal values of PaO2, PaCO2 and MAP for 36 h. In this
      way, investigators will be assessing the feasibility and effect of all three variables at the
      same time.

      The primary outcome is serum concentration of neuron-specific enolase (NSE) at 48 h after
      cardiac arrest. Feasibility outcome is between-group separation in PaO2, PaCO2 and MAP
      levels. Secondary outcomes include continuous monitoring of cerebral oxygenation, EEG and ECG
      for 48 h, the levels of NSE, S100B and cardiac troponin at randomization and 24, 48 and 72 h
      after cardiac arrest and neurological assessment at 6 months after cardiac arrest.
    


Intervention name(s): Low normal PaCO2; High normal PaCO2; Low normal PaO2; High normal PaO2; Low normal MAP; High normal MAP
Intervention type(s): Other; Other; Other; Other; Other; Other
Intervention description(s): 4.5-4.7 kPa; 5.8-6.0 kPa; 10-15 kPa; 20-25 kPa; 65-75 mmHg; 80-100 mmHg
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Out-of-Hospital Cardiac Arrest; Resuscitation; Hypoxia-Ischemia, Brain
A Multicenter, Placebo-controlled, Double-blind Investigative Extension Trial of the Safety and Efficacy of Aripiprazole in the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episode
Condition: Bipolar I Disorder
MeSH terms: Bipolar Disorder
Study type: Interventional
Phase: Phase 3

Summary: 
      To investigate the safety and efficacy of long-term administration of aripiprazole by
      performing extended administration of the treatment administered in the preceding
      multicenter, double-blind, placebo-controlled, parallel group-comparison trial of
      aripiprazole in patients with bipolar disorder experiencing a manic or mixed episode (Study
      031-06-003, hereafter "Study 003") in a double-blind manner to those patients who complete
      Study 003 and demonstrate drug efficacy.
    


Intervention name(s): Aripiprazole; placebo
Intervention type(s): Drug; Drug
Intervention description(s): oral, 24mg(4 tablets)/day; oral, 0mg(4tablets)/day
Other intervention name(s): OPC-14597; OPC-14597
Intervention MeSH terms: Aripiprazole
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Transcranial Direct Current Stimulation (tDCS) Augments the Effects of Gamified, Mobile Attention Bias Modification
Condition: Anxiety; Stress
Study type: Interventional
Phase: Phase 1

Summary: 
      The present study tested whether transcranial direct current stimulation (tDCS) across the
      prefrontal cortex (PFC), versus sham stimulation, effectively augments the beneficial effects
      of a gamified attention bias modification training (ABMT) mobile app.
    

Detailed description: 
      Anxiety-related attentional bias (AB) is the preferential processing of threat observed in
      clinical and sub-clinical anxiety. Attention bias modification training (ABMT) is a
      computerized cognitive training technique designed to systematically direct attention away
      from threat and ameliorate AB, but mixed and null findings have highlighted gaps in our
      understanding of mechanisms underlying ABMT and how to design the most effective delivery
      systems. One neuromodulation technique, transcranial direct current stimulation (tDCS) across
      the prefrontal cortex (PFC) may augment the effects of ABMT by strengthening top-down
      cognitive control processes, but the evidence base is limited and has not been generalized to
      current approaches in digital therapeutics, such as mobile applications. The present study
      tested whether tDCS across the PFC, versus sham stimulation, effectively augments the
      beneficial effects of a gamified ABMT mobile app. Thirty-eight adults (Mage = 23.92, SD =
      4.75; 18 females) evidencing low-to-moderate anxiety symptoms were randomly assigned to
      active or sham tDCS for 30-minutes while receiving ABMT via a mobile app. Participants
      reported on potential moderators of ABMT, including life stress and trait anxiety. ECG was
      recorded during a subsequent stressor to generate respiratory sinus arrhythmia (RSA)
      suppression as a metric of stress resilience.
    

Intervention name(s): ABMT; Transcranial direct current stimulation
Intervention type(s): Behavioral; Other
Intervention description(s): mobile attention bias modification training for anxiety, using the app Personal Zen; Soterix 1X1 tDCS Limited Total Energy (LTE) Stimulator
Other intervention name(s): Personal Zen; tDCS
Allocation: Randomized
Intervention model: Factorial Assignment
Intervention model description: All participants received active behavioral intervention combined with either active brain stimulation or sham stimulation control
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Anxiety, stress
Correlation Between the Pulmonary Function Parameters and the Circulatory Parameters (PSV, EDV, RI) of Retrobulbar Blood Vessels (CRA, PCA, and OA) in 48 T2DM Patients Did Not Combinate With DR
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus, Type 2
Study type: Observational

Summary: 
      Objective: The main target of this study was to research the correlation between the
      pulmonary function and the circulatory parameters of retrobulbar blood vessels in patients
      with type 2 diabetes (T2DM) without diabetic retinopathy (DR).

      Method: T2DM patients without DR were choose to research the correlation between the
      pulmonary function and the circulatory parameters of retrobulbar blood vessels. The primary
      endpoints were the pulmonary function parameters; The secondary endpoints were the HbA1c,
      FPG, 2hPG, WC, and BMI. The tertiary endpoints were the blood-fat; In addition, the
      retrobulbar circulation in the retrobulbar blood vessels were evaluated using color doppler
      imaging (CDI).
    

Detailed description: 
      Pulmonary function parameters (VC%, FVC%, FEV1%, PEF%, MVV%, TLC%, FEV1/FVC%, DLCO%, and
      DLCO/VA%); the retrobulbar circulation (PSV, EDV, RI);retrobulbar blood vessels (CRA, PCA,
      and OA);blood-fat(TC, HDL-C, LDL-C, and TG).

      Pulmonary function was measured by spirometer which was provided by Jaska Corporation in
      Japan, model number: HI-101; The CDI recordings were taken using a Powervision SSA-380A
      (Toshiba, Japan) using a 7-MHz transducer.
    

Intervention name(s): spirometer;Intraocular pressure;Color doppler imaging
Intervention type(s): Device
Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Investigators selected 60 patients (34 males, 26 females) with T2DM from the the diabetic
        outpatient clinic in Shenyang the Fourth Hospital of People, but only 48 patients (26
        males, 22 females) can be researched in our study. All patients were provided a diet and
        exercise program by professional nutritionists. The race ratio (all were Chinese Hans), age
        (range from 34 to 68 years), diabetes duration (range from 3 to 12 years), BMI (range from
        20 to 30 kg/m2), HbA1c [ range from 7.0 % (53 mmol/mol) to 10 % (86 mmol/mol) ]. Through
        the detecting, we excluded 6 patients (4 were in A1 stage, 2 was in A2 stage) because of
        DR. Finally, 48 patients (26 males, 22 females) completed the study.