Monosodium L-glutamate (MSG) on Satiety
Condition: Nutrition Intervention
Study type: Interventional

Summary: 
      The objective of this study is to compare energy intake following consumption 0.5% MSG versus
      a control with no added MSG and matched for sodium in healthy non-smoking premenopausal
      female adults.
    

Detailed description: 
      The study is a randomized, 2-arm, double-blind, placebo-controlled, Latin square cross-over
      clinical trial to assess the impact of 0.5% MSG on total and meal/snack-specific energy
      intake and on subjective ratings of appetite compared to sodium. Subjects will partake in an
      adaptation visit to avoid first order effects and will not be included in the randomization.

      A total of 75 healthy premenopausal women aged 19 to 60 y (inclusive) will be randomized to a
      sequence of test product administration. Participants will consume 1 of 2 test products,
      based on randomization sequence at each test period visit. Carrot and coriander soup (0.5%
      MSG + 0.48% salt) or negative control match for sodium (no MSG + 0.635% salt).

      Participants will be required to meet several inclusion and exclusion criteria, which will be
      assessed at the screening visit, including a health questionnaire, medical/medication
      history, eating behavior questionnaires, depression questionnaire and anthropometric
      measurements. After assessment of the eligibility criteria (see Eligibility section) at the
      screening visit, qualified participants will be invited to participate in the study and will
      be familiarized with the completion of VAS for subjective ratings of hunger, fullness,
      satiety and desire to eat.

      Over a 3-week period, participants will come to the test facility on three occasions to
      complete the study with a one week wash-out period between each visit. Participants will fast
      overnight before each visit and consume the same evening meal before each test day.

      Participants arrive at the research center at approximately 8:15am. Right before serving the
      breakfast meal, participants will be asked to complete a satiety rating questionnaire (using
      visual analogue scale (VAS)). At 8:30am, participants will consume breakfast (cereal and
      milk). Immediately after eating breakfast participants will complete another VAS
      questionnaire as well as a taste/liking meal evaluation. Thereafter, VAS will be completed at
      30 minute intervals.

      Four hours after the breakfast meal (at 12:30pm), participants will be given one of the test
      products (carrot and coriander soup with or without MSG) based on their randomization
      schedule. Subjects will have 10 min to consume the soup in its entirety. Following test
      product/soup intake, subjects will complete a taste/liking meal evaluation and VAS
      questionnaire. Immediately after completion of the questionnaire (12:40pm), an ad lib lunch
      buffet will be provided and participants will be instructed to eat as much as or as little as
      they desire (within 30 min) until comfortably full, followed by completing a taste/liking
      meal evaluation and VAS questionnaire. Thereafter, VAS will be completed at 30 minute
      intervals.

      At 3:30pm, participants will be provided with their second portion of the test product to
      consume within 10 min, followed by completing a taste/liking meal evaluation and VAS
      questionnaire. Immediately after test soup administration and completing questionnaires, an
      ad lib snack buffet will be provided and participants will be instructed to eat as much as or
      as little as they desire within 20 min, followed by completing a taste/liking meal evaluation
      and VAS questionnaire. VAS assessment will continue at 30 min intervals thereafter until
      5:00pm ending the study day. Participants' next visit will be scheduled after 1 week wash-out
      period: all procedures are identical with the exception of the test treatment soup consumed
      by participants.
    

Intervention name(s): Soup with MSG; Control soup no MSG
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 0.5% MSG + 0.48% salt; Negative control match for sodium (no MSG + 0.635% salt)
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: Monosodium L-Glutamate (MSG); Satiety; Soups; Energy Intake; Snack Intake