Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures
Condition: Eyelid Tumor; Eyelid Bump; Eyelid Deformity; Eyelid Abscess; Eyelid Boil; Eyelid Papilloma; Anesthesia, Local; Ophthalmology
MeSH terms: Papilloma
Study type: Interventional
Phase: Phase 4

Summary: 
      The investigators aim to assess whether bacteriostatic saline provides the same level of
      anesthesia as traditional local anesthesia while reducing pain associated with medication
      infusion in minor eyelid procedures
    

Detailed description: 
      Benzoyl alcohol is an aromatic alcohol that has been used in healthcare primarily as an
      antibacterial preservative agent in bacteriostatic saline. It has also been shown to have
      anesthetic properties, and has been demonstrated to cause less pain with infusion compared to
      lidocaine, while maintaining adequate pain relief. The use of bacteriostatic saline alone as
      an anesthetic for incisional procedures in the periocular area has not yet been studied. The
      purpose of this study was to determine whether bacteriostatic saline provides an adequate
      level of anesthesia for minor in-office eyelid procedures while allowing for reducing pain
      associated with medication infusion compared with traditional local anesthetic agents. To
      assess this, the investigators will recruit 150 patients aged 18 or older undergoing minor
      eyelid procedures including eyelid biopsies, chalazion removal from outpatient oculoplastics
      clinics at UCSF. Patients will be randomized in a 1:1 fashion to undergo local anesthetic
      with either 1% lidocaine with 1:100,000 epinephrine or 0.9% bacteriostatic saline. Primary
      outcome measure will be pain level on a scale of 1-10 with regards to injection and procedure
      itself. These will be compared between the two groups. The investigators hypothesize that
      bacteriostatic saline is superior to lidocaine with epinephrine in terms of pain with
      injection, but will result in a similar pain level during the procedure.
    

Intervention name(s): 0.9% Bacteriostatic Local Anesthetic Injection; 1% Lidocaine with 1:100,000 epinephrine Local Anesthetic Injection; Eyelid Lesion Removal
Intervention type(s): Drug; Drug; Procedure
Intervention description(s): Following research and procedural consent, local anesthetic injection will be carried out using a standard 1 cc of local anesthetic corresponding to the study arm (0.9% bacteriostatic saline or 1% lidocaine with 1:100,000 epinephrine). Prior to anesthetic administration, the procedure site will be cleaned using standard measures. A 30 gauge needle on a 3 centimeter cubed volume syringe will be utilized. Five minutes will be given for local anesthetic to take effect.; Following research and procedural consent, local anesthetic injection will be carried out using a standard 1 cc of local anesthetic consisting of a commercially available mixture of 1% lidocaine with 1:100,000 epinephrine. Prior to anesthetic administration, the procedure site will be cleaned using standard measures. A 30 gauge needle on a 3 centimeter cubed volume syringe will be utilized. Five minutes will be given for local anesthetic to take effect.; Following anesthesia administration, patient will proceed with recommended eyelid lesion removal. The procedure site will be cleaned according to standard protocol, and standard technique for lesion removal will be performed, which will vary according to type of lesion but may involve use of Westcott scissors, forceps, #15 or #11 blades or other oculoplastics administration. The exact procedural details will be at the discretion of the surgeon.
Intervention MeSH terms: Lidocaine; Epinephrine; Anesthetics, Local; Anesthetics
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: Oculoplastics; Local Anesthesia; Eyelid Anesthesia; Periocular Anesthesia