bioihbjkbjnl/mcl2 huggingface dataset:
Macintosh Laryngoscope Assisted Fiberoptic Intubation
Condition: Difficult Intubation
Study type: Interventional

Summary: 
      During fiberoptic endotracheal intubation, the perfect airway exposure produced by the
      classic curved Macintosh laryngoscope in place of head tilt -chin lift-jaw thrust maneuver
      may increase the accuracy and produce rapid direct vocal cord access in a short time under
      Inhalation anesthesia to maintain the respiratory drive for grade III&VI Modified Mallampati
      .
    

Detailed description: 
      Managing difficult airway is critical for anesthesia-related morbidity and mortality.
      Fiberoptic laryngoscope is a reliable tool for endotracheal intubation in difficult airway
      cases (Modified Mallampatti III&IV), but always there is difficulty to visualize the glottis
      due to airway tendency to collapse, classically a specific fiberoptic airway with a side way
      is used and it may added head tilt chin lift jaw thrust. A new technique utilizing
      sevoflurane anesthesia to maintain the respiratory drive without exposing the patient to the
      stress of the awake airway instrumentation. Simultaneous utilization of both Macintosh curved
      laryngoscope and Fiberoptic bronchoscope during Endotracheal intubation (ETT) will be
      examined for the efficacy during difficult airway management.

      All patients should be examined preoperatively for the scoring Modified Mallampati or non
      tongue protrusion mallampati (NT-MMT) airway score. The pharyngeal structures were then
      evaluated and the best view (lowest class) was recorded. The classification follows m-MMT and
      is as follows: class 1, full visibility of tonsils, uvula, and soft palate; class 2,
      visibility of hard and soft palate, upper portion of tonsils and uvula; class 3, visibility
      of the soft and hard palate and base of the uvula; and class 4, visibility of only the hard
      palate, class III or IV patients were included in the study. Inhalational anesthesia use
      maintains the respiratory drive of the patient allowing less stressful technique.
    

Intervention name(s): fiberoptic, airway; fiberoptic, Machintosh
Intervention type(s): Device; Device
Intervention description(s): classic fiberoptic bronchoscope, fenstrated airway; oral fiberoptic brochoscopic, Machintosh laryngoscope
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Multicultural Healthy Diet to Reduce Cognitive Decline
Condition: Diet Modification; Cognitive Decline; Cognitive Change
MeSH terms: Cognitive Dysfunction
Study type: Interventional

Summary: 
      This is a pilot randomized controlled clinical trial is designed to investigate whether the
      Multicultural Healthy Diet (MHD), an anti-Inflammatory diet tailored to a multi-cultural
      population, can improve cognitive functioning in a middle aged (40-65 yr) urban population in
      Bronx, New York compared to a usual diet.
    

Detailed description: 
      The Multicultural Healthy Diet (MHD) is a pilot randomized controlled clinical trial designed
      to test the effects of an 18 month intervention on cognitive function among 290 middle-aged
      individuals (40-65 yr). MHD is an anti-inflammatory diet tailored to a multicultural
      population. The emphasis of the intervention is on plant-based foods and limited animal and
      high saturated fat foods with focus on anti-inflammatory foods/food components specific to
      the cultural context of the participants. The trial will employ a parallel group design
      comparing the effects of the dietary intervention (MHD) on cognitive status to those of the
      control diet or usual diet plus modules on self-care matters such as dealing with aches and
      pains of aging, obtaining a health care proxy ,etc. To show that MHD can be adapted to this
      population serum biomarkers indicative of the MHD diet pattern such as fatty acid profile as
      well as other key nutrition biomarkers will be evaluated. Other aims include testing whether
      the MHD intervention can benefit cognitive function using real-time ambulatory assessments.
      The investigators will also assess plasma markers of oxidative stress and inflammation.
      Components of the MHD diet that are associated with stable or improved measures of cognition
      will also be evaluated. The clinical site for the proposed study is at the Albert Einstein
      College of Medicine; the ambulatory cognitive assessment reading center is at Pennsylvania
      State University, State College; the statistical core is at the Kaiser Permanente Washington
      Health Research Institute and the laboratory for biospecimen analysis is at the University of
      Minnesota.
    

Intervention name(s): Multicultural Healthy Diet; Usual Diet plus Self-Care
Intervention type(s): Other; Other
Intervention description(s): An anti-inflammatory dietary pattern consists of a dietary pattern that has high anti-inflammatory potential; Usual diet plus sessions that focus on self-care such as dealing with aches and pains of aging.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: This is a pilot randomized clinical trial to the effects of an anti-inflammatory diet on cognition in a middle-aged cohort. The comparison arm will receive information on self-care matters such as aches and pains of aging.
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Metabolic Control Before and After Supplementation With Lactobacillus Reuteri DSM 17938 in Type 2 Diabetes Patients
Condition: Type 2 Diabetes; Insulin Resistance
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2; Insulin Resistance
Study type: Interventional
Phase: Early Phase 1

Summary: 
      Recent data suggest that the trillions of bacteria in the investigators gastrointestinal
      tracts (gut microbiota) can function as an environmental factor that modulates the amount of
      body fat. Obese individuals have an altered gut microbiota and germ-free mice are resistant
      to developing diet-induced obesity and have lower fasting insulin and glucose and improved
      glucose tolerance. Administration of the probiotic bacterium Lactobacillus strain in
      fermented milk for 12 weeks reduced adiposity and body weight in obese adults, possibly by
      reducing lipid absorption and inflammatory status. However, there are no studies to the
      investigators knowledge that address whether probiotic supplementation improves glucose
      metabolism in type 2 diabetes patients.
    


Intervention name(s): Lactobacillus reuteri DSM 17938
Intervention type(s): Dietary Supplement
Intervention description(s): Ordinary treatment against type 2 diabetes is supplemented with one tablet containing 100 million Lactobacillus reuteri DSM 17398, once daily for 12 weeks
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Lactobacillus; Gut microbiota; Diabetes mellitus
Glucocorticoid Induced Whole Body Catabolisme
Condition: Whole Body Catabolisme Induced by Glucocorticoids
Study type: Interventional
Phase: Phase 2

Summary: 
      The main purpose of the trial is to advance our knowledge on the possible mechanism
      underlying the catabolic effects of long-term treatment with glucocorticoid.
    

Detailed description: 
      Long-term treatment with glucocorticoid induces a general state of catabolism and increases
      insulin resistance. The underlying mechanisms are insufficiently characterized, however
      glucocorticoid induced changes of Growth Hormone (GH) and the Insulin-like growth factor I
      (IGF-I) appear to be of outmost importance.

      We wish to investigate the mechanism behind glucocorticoid induced catabolism and insulin
      resistance.

      More specific we wish to investigate:

        -  Whether glucocorticoid induces IGF-I inhibiting substances in serum or interstitial
           fluid that block the ability of IGF-I to phosphorylate its receptor in vitro

        -  Whether glucocorticoid inhibits intracellular IGF-I and insulin signaling in vitro and
           in vivo

        -  The mechanisms by which growth hormone counteracts the CG-mediated inhibition of IGF-I
           action
    

Intervention name(s): Glucocorticoids; Calcium Supplement
Intervention type(s): Drug; Drug
Intervention description(s): Prednisolone 37.5 mg x1 for 5 days; Placebo
Other intervention name(s): Prednisolone; Placebo
Intervention MeSH terms: Prednisolone; Calcium; Glucocorticoids
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Protein breakdown; Insulin resistance; Glucose intolerance; Lipolysis
Vaginal Estriol in Multiple Sclerosis
Condition: Multiple Sclerosis; Neurogenic Bladder
MeSH terms: Multiple Sclerosis; Urinary Bladder, Neurogenic; Sclerosis
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      Study to evaluate the efficiency of vaginal estriol, as a treatment for urogenital symptoms
      in female patients with RRMS. The secondary objective is to evaluate the potential role of
      vaginal estriol in re-myelination in RRMS patients.
    

Detailed description: 
      Pilot project to determine the effectiveness of 1 mg transvaginal estriol, as an adjunctive
      therapy for female MS patients. The goal is to recruit 20 patients from the MS clinic in the
      neurology department of Texas Tech University Health Sciences Center. This study has been
      planned in collaboration with reproductive endocrinology, endocrinology, gynecology and basic
      science. The 1mg transvaginal dose was chosen after careful search of the literature and
      consultation with collaborators.

      Single-group pilot study.

      Subjects:

      Patients with relapsing remitting MS and urogenital symptoms (frequency, urgency, frequent
      urinary tract infections, incontinence) will be invited to participate in the study.
      Enrollment will be during their scheduled clinic appointment. Some candidates (patients of
      the primary investigator) may be contacted by phone and invited to participate in the study.

      The clinical trial will be explained to potential participants in detail, reviewing the
      objectives and methodology of the study. There will be adequate time allotted to answer any
      questions or concerns from the potential participants. Those patients interested in
      participating in the study will be asked to sign the consent form. In order to remind
      patients about their follow-up visits, lab work, etc., they will be contacted routinely.
      Participants will be instructed to call in case of questions or concerns.

      Patients will be evaluated clinically during their scheduled follow up in which a full
      neurological exam will be performed during each visit. Patients will be instructed by the
      primary investigator how to correctly use the vaginal cream. This will be done at their
      enrolment and reinforced by the principal investigator, during their follow up visits.
    

Intervention name(s): vaginal estriol
Intervention type(s): Drug
Intervention description(s): Estriol vaginal cream will be formulated by Twin Oaks specialty pharmacy-by the same compound specialist. 30 mg estriol powder will be mixed with 5 mL of propylene glycol and 22 g of vaginal base cream. The product can be stored at room temperature and has a shelf life of up to 4 months. It comes with an applicator.
Other intervention name(s): estriol cream
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: This is a single-group prospective repeated-measures pilot trial. Duration is 12 months,
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: remyelination; urogenital health; multiple sclerosis
Effect of Nicotine on Chronic Pelvic Pain
Condition: Pelvic Pain
MeSH terms: Pelvic Pain
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to test whether transdermal nicotine reduces pain among women
      with chronic pelvic pain.
    

Detailed description: 
      Potential subjects are female non-smokers presenting to their physicians for treatment of
      chronic pelvic pain. When consented, the subjects fill out a questionnaire on demographic
      information and pain experience. The trial is conducted at home over three days. Each subject
      uses three different levels of nicotine (0mg, 5mg, and 10mg) administered in a random order;
      the study is double-blinded and patients act as their own controls. Subjects apply the
      placebo or nicotine patches in the morning and remove them in the evening when they fill out
      a pain diary for the day. During the study, patients will continue their typical course of
      pain medication and report pain medication use in the pain diary.
    

Intervention name(s): Placebo; Nicotine (5 mg); Nicotine (10 mg)
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Subjects applied a placebo patch (0 mg) in the morning and removed it at bedtime for one day.; Subjects applied a nicotine patch (5 mg) in the morning and removed it at bedtime for one day.; Subjects applied a nicotine patch (10 mg) in the morning and removed it at bedtime for one day.
Intervention MeSH terms: Nicotine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: chronic pain; pelvic pain; nicotine patch
A Phase I Clinical Trial of BAT5906 Injection in Patients With Wet Age-related Macular Degeneration
Condition: Age-related Macular Degeneration
MeSH terms: Macular Degeneration
Study type: Interventional
Phase: Phase 1

Summary: 
      A Phase I Clinical Trial for BAT5906(single-dose;for injection) on Safety and
      Pharmacokinetics for Patients with Age-related macular degeneration.
    

Detailed description: 
      The primary objective: To evaluate the safety and Pharmacokinetics of BAT5906 (single-dose
      Ophthalmic Intracireal Iinjection) in patients wAMD , when the injection dosage escalates.

      The Secondary objective: To evaluate the immunogenicity profile of BAT5906; To evaluate the
      pharmacodynamics and therapeutic efficacy profile of BAT5906.
    

Intervention name(s): BAT5906 injection
Intervention type(s): Drug
Intervention description(s): Signal dose escalation starting from 0.3mg. Route of administration: intravitreal injection
Other intervention name(s): No Other Intervention Names
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Efficacy of Acupuncture for Chronic Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a trial to clarify the extent to which acupuncture needling can diminish the effect
      of chronic back pain on patient functioning and symptoms.
    

Detailed description: 
      This is a 4-arm multi-site randomized controlled trial to clarify the extent to which various
      types of acupuncture needling can diminish the effect of chronic low back pain on patient
      functioning and symptoms. Reviews have noted the poor quality of research in this area and
      urged that scientifically rigorous studies be conducted. Recent higher quality trials suggest
      acupuncture is a promising treatment for back pain. This study directly addresses
      methodological shortcomings that have plagued previous studies. A total of 640 subjects (160
      per arm) with low back pain lasting at least 3 months will be recruited from group model HMOs
      in Seattle, WA and Oakland, CA. They will be randomized to one of three different methods of
      stimulation of acupuncture or to continue usual medical care. Ten treatments will be provided
      over 7 weeks. The primary outcomes, dysfunction and bothersomeness of low back pain, will be
      measured at baseline, and after 8, 26, and 52 weeks by telephone interviewers masked to
      treatment. Analysis of covariance within an intention-to-treat context will be used to
      analyze the data. Because chronic back pain is a major public health problem and the top
      reason patients seek acupuncture treatment, a clear, unambiguous assessment is critical for
      making informed decisions about whether acupuncture should be included as part of
      conventional care for back pain or covered by insurance. Results of this study will provide
      the clearest evidence to date about the value of acupuncture needling as a treatment for
      chronic low back pain.
    

Intervention name(s): Accupuncture
Intervention type(s): Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: low back pain; acupuncture
Levothyroxine for Children With Euthyroid Sick Syndrome
Condition: Euthyroid Sick Syndrome
MeSH terms: Euthyroid Sick Syndromes; Syndrome
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to determine whether levothyroxine is effective and safe in the
      treatment of children with euthyroid sick syndrome, hospitalized in a pediatric intensive
      care unit.
    

Detailed description: 
      Children with euthyroid sick syndrome, hospitalized in a pediatric intensive care unit, will
      be randomised to receive either Levothyroxine or placebo, to determine if it diminishes
      mortality.
    

Intervention name(s): Levothyroxine; Calcium magnesia
Intervention type(s): Drug; Other
Intervention description(s): 3 mcg/kg/day; Placebo.
Other intervention name(s): Brand: Eutirox.
Intervention MeSH terms: Magnesium Oxide; Calcium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Euthyroid Sick Syndromes; Thyroxine; Intensive care
Contribution of L-Tyrosine to Human Decision Making in Stressful Situations
Condition: Stress, Psychological
MeSH terms: Stress, Psychological
Study type: Interventional

Summary: 
      L-tyrosine is a chemical precursor of dopamine. Under specific conditions, tyrosine
      administration can increase brain dopamine levels and therefore several studies have explored
      whether tyrosine supplementation can have a beneficial effect on cognitive and behavioural
      performance that is dependent on dopaminergic function. However, the effects of tyrosine
      supplementation are mixed: some studies show positive effects while others do not. Stress
      leads to an increase in dopaminergic activity and turnover in the brain, resulting in a
      decrease in brain dopamine levels. We propose to study the contribution of tyrosine to
      decision making and more particularly to the processes of response selection (mediated by the
      prefrontal cortex and under the influence of the dopaminergic system) in stressful
      situations.
    


Intervention name(s): Blood collection; L-Tyrosine 500 Mg; Placebo; Cognitive tasks; Stress exposure; Anxiety scale; Electromyography (EMG); Electroencephalography (EEG)
Intervention type(s): Biological; Drug; Drug; Behavioral; Other; Behavioral; Device; Device
Intervention description(s): A blood sample will be collected before and after treatment administration; The participants will be administered 4 capsules of L-Tyrosine 500 mg per oral route; The participants will be administered 4 capsules of Lactose 500 mg (placebo) per oral route; The participants will perform cognitive decision-making tasks: Simon task and masking task after treatment administration; Unpleasant but not painful skin stimulations will be administered to the participants at variable intervals on the left leg during the cognitive tasks; Spielberger's State Trait Anxiety Inventory (STAI) will be filled by the participants before and after cognitive tasks; Electromyography measurements will be performed during cognitive tasks.; Electroencephalography measurements will be performed during cognitive tasks.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: The study is composed of 4 arms:
Tyrosine treatment without stress exposure
Tyrosine treatment with stress exposure
Placebo treatment without stress exposure
Placebo treatment with stress exposure
Every participants will participate in the 4 arms in a random order.
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: L-tyrosine
A Phase 2, Randomized, Placebo-controlled, Double-blind Study of EG017 in Female Patients With Stress Urinary Incontinence
Condition: Stress Urinary Incontinence
MeSH terms: Urinary Incontinence; Enuresis; Urinary Incontinence, Stress
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine whether EG017 is safe and effective in the
      treatment of stress urinary incontinence in postmenopausal women.
    

Detailed description: 
      The main purpose of this study is to assess the efficacy of EG017 in female patients with
      stress urinary incontinence (SUI) compared with placebo as measured by the percent change in
      the urinary incontinence volume measured in a 1-hour pad test from baseline at week 12.
    

Intervention name(s): EG017 3mg; EG017 6mg
Intervention type(s): Drug; Drug
Intervention description(s): EG017 3mg/day Oral administration for 12 weeks, once daily; EG017 6mg/day Oral administration for 12 weeks, once daily
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: stress urinary incontinence; Selective Androgen Receptor Modulator (SARM)
Comparison of Dental Pain Response in Children
Condition: Dental Anxiety
MeSH terms: Toothache
Study type: Interventional

Summary: 
      Study involves the observation of the child's behavior during a dental treatment procedure.
      This allows for the evaluation of the child's experience of pain and discomfort through their
      facial expressions, body movements, and vocalizations during the procedure.
    


Intervention name(s): experimental
Intervention type(s): Behavioral
Intervention description(s): During the procedure, the chairside assistant can capture video recordings of the child's behavior and facial expressions. These videos can be later reviewed by a trained observer who can evaluate the child's pain experience
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Whole Body Vibration in Chronic Obstructive Pulmonary Disease
Condition: COPD
MeSH terms: Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Study type: Interventional

Summary: 
      The investigators designed the current study with the main objective of determining whether
      Whole Body Vibration Training (WBVT) alone improves muscular force and/or modifies the
      functional capacity parameters in severe Chronic Obstructive Pulmonary Disease (COPD)
      patients referred to a rehabilitation programme.
    


Intervention name(s): A vertical vibration platform Fitybe
Intervention type(s): Device
Intervention description(s): They performed 6 series, and each series consisted of four 30-second repetitions with a frequency of 35 Hz and 2 millimeters of amplitude, with 60 seconds of rest between each series.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment