bioihbjkbjnl/mcl2 huggingface dataset:
Periodontal Disease Prevention Study
Condition: Periodontitis
MeSH terms: Periodontitis; Periodontal Diseases
Study type: Observational

Summary: 
      This study is one component of a program to improve the maintenance of good dental health and
      the prevention of disease by use of risk stratification methods to efficiently guide
      increased preventive services to adult dental patients who are at increased risk for the
      major dental diseases, caries and adult periodontitis.

      The investigators will use a retrospective cohort model to analyze a large dental claims
      database to determine if the frequency of preventive services influenced the periodontal
      disease outcomes and to determine if periodontal risk assessment information can be used to
      stratify dental patients into "high risk" and "low risk" categories that influence the effect
      of preventive services on periodontitis outcomes.

      Primary Objective To evaluate whether dental patients who are classified as "low risk" for
      periodontal disease progression, based on history of periodontitis (claims history), smoking,
      diabetes, and IL-1 genetic variations, have different primary and secondary endpoints if they
      had two dental cleanings per year compared to one cleaning per year.

      Secondary Objectives To evaluate whether dental patients who are classified as "high risk"
      for periodontal disease progression, based on a history of periodontitis, smoking, diabetes,
      and IL-1 genetic variations, have different primary and secondary endpoints if they had two
      dental cleanings per year compared to one cleaning per year.

      To evaluate whether dental patients who have had one dental cleaning per year have different
      primary and secondary endpoints if they are classified as "low risk" for periodontal disease
      compared to patients who are classified as "high risk." To evaluate whether dental patients
      who have had two dental cleaning per year have different primary and secondary endpoints if
      they are classified as "low risk" for periodontal disease compared to patients who are
      classified as "high risk."
    


Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Study may include all participants who are 34-55 years old in 1992 (48-68 years old in
        2010) and who have at least a 15-year dental claim history with Delta Dental.
      
Biospecimen description: 
      buccal swabs
    
Keywords: periodontitis
Use of Diathermy Versus Blunt Dissection in TEP for Inguinal Hernia
Condition: Seroma; Hernia, Inguinal
MeSH terms: Hernia; Hernia, Inguinal
Study type: Interventional

Summary: 
      There is a long debate whether monopoloar or blunt dissection should be adopted in TEP to
      minimise the chance of seroma formation. This study aims at study the effect on seroma
      formation (and pre-peritoneal drain output) by 2 techniques in randomised controlled trial.
    

Detailed description: 
      There is a long debate whether monopoloar or blunt dissection should be adopted in TEP to
      minimise the chance of seroma formation. This study aims at study the effect on seroma
      formation (and pre-peritoneal drain output) by 2 techniques in randomised controlled trial.

      all male and female patients presented with first occurrence, unilateral inguinal hernia
      anticipated for laparoscopic TEP are included into study after informed consent. Patients are
      randomized into "diathermy-preferred" (DP) group and "blunt dissection-preferred" (BDP) group
      just before commence of operation after general anaethesia. Surgeons are instructed to use
      monopolar energy as main dissection method for whole operation if possible (DP), where as
      blunt dissection is the preferred choice in BDP group but it is allowed to use monopolar
      energy if needed. Total energy time is measured by a specially designed device attaching to
      the monopolar pedals as accurate as to millisecond (ms). Pre-peritoneal drains are inserted
      for drainage and removed 23 hours after operation. Energy time, drainage output, ultrasonic
      seroma sizes at day 1, day 6, 1 month post-operations, recurrence are compared between 2
      groups.
    

Intervention name(s): Monopolar energy; Blunt dissection
Intervention type(s): Procedure; Procedure
Intervention description(s): Monopolar energy in TEP for inguinal hernia; Blunt dissection in TEP for inguinal hernia
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: the effect on seroma formation and output of pre-peritoneal drain after TEP by monoploar diathermy or blunt dissection approach will be studied
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Study of Tumor Samples From Patients With Ependymoma Treated on the Children's Oncology Group ACNS0121 Trial
Condition: Childhood Infratentorial Ependymoma; Childhood Supratentorial Ependymoma; Newly Diagnosed Childhood Ependymoma
MeSH terms: Ependymoma
Study type: Observational

Summary: 
      This research trial studies tumor samples from patients with ependymoma treated on the
      Children Oncology Group ACNS0121 trial. Studying samples of tumor tissue from patients with
      cancer in the laboratory may help doctors learn more about changes that occur in DNA and
      identify biomarkers related to cancer. It may also help doctors find better ways to treat
      cancer.
    

Detailed description: 
      PRIMARY OBJECTIVES:

      I. To examine the prognostic role of histopathological variables, in particular cellular
      density, mitotic count, and tumor cell invasion in intracranial pediatric ependymomas.

      II. To study whether hTERT expression and telomere dysfunction correlate with
      progression-free survival (PFS) and overall survival (OS) in pediatric intracranial
      ependymoma.

      III. To perform a genome-wide copy number screen and validation of copy number abnormalities
      (CNAs) on formalin-fixed paraffin-embedded (FFPE) ependymomas using Affymetrix Molecular
      Inversion Probe (MIP) arrays and interphase fluorescence in situ hybridization (iFISH). IV.
      To evaluate associations between infiltration of immune markers and PFS as well as OS in
      pediatric ependymoma.

      V. To examine the role of 1q gain and 9p deletion in pediatric ependymomas by exploring their
      association with PFS and OS in a multivariable model.

      VI. To establish the frequency and clinicopathological associations of mutations in genes
      involved in Notch pathway signaling.

      OUTLINE:

      Archived tumor tissue samples are analyzed for cellular density, mitotic count, tumor cell
      invasion, hTERT expression, telomere dysfunction, 1q gain, 9p deletion, and genetic mutations
      by IHC, Affymetrix Molecular Inversion Probe (MIP) arrays, and fluorescence in situ
      hybridization (FISH). Results are then correlated with patient-outcome variables and known
      risk factors, namely gender, age at diagnosis, tumor location infratentorial vs.
      supratentorial), tumor grade (differentiated vs anaplastic), and extent of surgery as well as
      pathologic variables.
    

Intervention name(s): laboratory biomarker analysis
Intervention type(s): Other
Intervention description(s): Correlative studies
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with ependymoma treated on the Children Oncology Group ACNS0121 trial
      
Biospecimen description: 
      Archived tumor tissue
The Effect Thirsty and Oral Care Frequency of Cold Water
Condition: Thirst
Study type: Interventional

Summary: 
      Surgical patients, and especially bariatric patients, are high-risk patients who may develop
      thirst due to intubation, blood loss, osmotic imbalance, and prolonged fasting. Nurses often
      have the perception that when the patient's oral intake is turned off, nothing can be done to
      prevent thirst and dry mouth. Thirst is one of the main stress factors that reduces the
      comfort of intensive care patients. So far, no assessment has been routinely used to assess
      thirst and dry mouth. However, thirst is a mitigable symptom that should be evaluated by the
      nurse.
    

Detailed description: 
      The data were collected by the researcher by face-to-face interview technique between April
      2022 and March 2023 in the groups participating in the study. It was applied to patients who
      agreed to participate by giving information about the purpose of the study to patients who
      met the research criteria. The patients were divided into 2 groups as study and control. In
      the study group, the intensive care oral care frequency assessment scale was applied to 55
      patients at the end of the 16th hour, in addition to the assessment of pain and thirst at the
      1st, 4th, 8th, and 16th hours postoperatively. It was applied to patients with a thirst of 3
      and above by spraying cold water into the mouth of the patient every hour. The standard oral
      care of the clinic was applied to the patients who needed oral care. In the control group,
      standard nursing care was applied to 55 patients with the pain, thirst and intensive care
      oral care frequency assessment scale at the 1st, 4th, 8th, and 16th hours postoperatively.
    

Intervention name(s): the intensive oral care
Intervention type(s): Behavioral
Intervention description(s): the intensive oral care
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Postoperative Period; ice; nursing; thirst; Intensive care units; mouth
Reversed TESS Shoulder Artroplasty
Condition: Humerus Fracture; Degenerative Shoulder Pain; Degenerative Supraspinatus Rupture
MeSH terms: Shoulder Pain; Rupture; Humeral Fractures
Study type: Observational

Summary: 
      Reverse total shoulder arthroplasty (RSA) is a accepted treatment for different shoulder
      diseases with improved functional outcome. This study has evaluated patients operated with
      reversed shoulder arthroplasty after 1,5-3 years postoperatively with patient reported
      outcome, clinical and radiological examination, complication and reoperations. The radiologic
      phenomenom and clinical impact of scapular notching (SN) and arm length difference has been
      evaluated.
    


Intervention name(s): Reversed shoulder arthroplasty
Intervention type(s): Procedure
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients undergone reversed shoulder arthroplasty at Sundsvall hospital, Sweden between
        2007-2012
      
Keywords: Reversed shoulder arthroplasty; Treatment; TESS
Comprehensive Voice Rehabilitation Program Compared With Vocal Function Exercises
Condition: Dysphonia
MeSH terms: Dysphonia; Hoarseness
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The purpose of this study is to evaluate the effectiveness and safety of the Comprehensive
      Voice Rehabilitation Program compared with Vocal Function Exercises in behavioral dysphonia.
    

Detailed description: 
      Introduction: Voice therapy is the best indication for the most voice disorders, with a
      strong degree of recommendation based on systematic reviews and randomized clinical trials,
      with a predominance of benefit over risk. Some speech therapy techniques are specific, others
      are organized principles or with eclectic approaches, that use a combination of strategies.
      So far, few studies have tested the effectiveness of treatment for dysphonia due to time
      spent, safety and improved quality of life more comprehensive as they are made in clinical.
      Objective: To evaluate the effectiveness and safety of the Comprehensive Voice Rehabilitation
      Program compared with Vocal Function Exercises in behavioral dysphonia. Methods: 106
      professional of voice with dysphonia behavior, between 18 and 50 years old and vocal
      complaints for more than six months. These professionals have been evaluated by an
      otolaryngologist, randomized to participate of Vocal Function Exercises arm or Comprehensive
      Voice Rehabilitation Program arm. Both arms were follow for six sessions with speech
      therapists and reassessed when finish the period and after one month. The primary outcomes
      assessed are: reduction of VHI score, improved voice quality in the CAPE-V and improves the
      larynx condition. Conclusions: The Comprehensive Voice Program has an eclectic approach and
      follows the philosophy of what is practiced in clinics in Brazil. We believe this program can
      demonstrate the power of voice therapy effectiveness more organized to solve problems, with
      shorter duration of treatment, benefit patient health and funding agencies such as Unified
      Public Health System (SUS) and health insurance.
    

Intervention name(s): Voice therapy
Intervention type(s): Behavioral
Intervention description(s): Voice therapy applied during 6 weeks.
Other intervention name(s): Voice treatment; SLP
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Voice disorders; Hoarseness; Therapy
Effect of N_Acetylcysteine on Liver Functions in Donors in Living Liver Transplantation
Condition: Liver Transplant; Complications
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      our practice for the past 10 years we have noticed a transitional impairment of liver
      function (elevated liver enzymes, total and direct bilirubin, and elevated serum lactate
      levels) following donors' liver resection. Several drugs have been investigation on liver
      regeneration , proven benefit of N-Acetylcysteine (NAC) on rats with steatohpatitis
    


Intervention name(s): N-Acetylecysteine; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): N-Acetylecysteine 150 mg/kg diluted in 100 ml glucose 5 % over 40 minutes followed by NAC 12.5 mg/kg in 500 ml glucose 5% over 4 hours, followed by NAC 6.25 mg/kg for 2 postoperative days; Ringer acetate continuous infusion at the same rate for 2 days.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Treatment of Apathy in Alzheimer's Disease With Modafinil
Condition: Apathy; Alzheimer's Disease
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 3

Summary: 
      This study examined the effects of modafinil on apathetic symptomatology, performance of
      activities of daily living (ADLs) and caregiver burden in individuals with Alzheimer's
      disease (AD).
    


Intervention name(s): Modafinil; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 100 mg in the morning for the first week and 200 mg in the morning for the remaining seven weeks; 100 mg in the morning for the first week and 200 mg in the morning for the remaining seven weeks
Other intervention name(s): Provigil
Intervention MeSH terms: Modafinil
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: apathy; Alzheimer's disease; activities of daily living performance; caregiver burden
Effectiveness of Atraumatic Restorative Treatment Using Glass Ionomer Cement of Different Costs
Condition: Dental Caries
MeSH terms: Dental Caries
Study type: Interventional

Summary: 
      Atraumatic Restorative Treatment (ART) is an alternative restorative technique for dental
      caries, applying the partial caries tissue removal philosophy using hand instruments,
      relative cotton rolls isolation, immediate restoration with Glass Ionomer Cements (GIC) and
      avoiding local anesthesia. The chosen material for this study will be the High Viscosity
      Glass Ionomer Cement (HVGIC) due to its unique physical-chemical properties as well as its
      applicability in challenging clinical situations where other materials would not be adequate.
      Although there are substantial evidences regarding GIC properties, information about GIC
      (with different costs) longevity is still weak. Therefore, the objective of this study is to
      assess the effectiveness of ART restorations performed with low-cost HVGIC in cavitated
      dentine carious lesions in primary and permanent molars. This will be a multicenter
      randomized controlled double-blind (patient and operator) clinical trial performed with 680
      primary and/or permanent molars in children between 4 and 9 years old presenting cavitated
      dentine carious lesions in occlusal and occlusal-proximal surfaces. The tooth will be
      considered as the unit sample, which will be randomly allocated to the groups through a
      generated random list numbers and distributed in dark sealed envelopes opened only by dental
      assistants. Teeth in the test group will be submitted to restorative treatment with HVGIC
      Vitro Molar and those in the control group with HVGIC Fuji IX. The restoration effectiveness
      will be assessed by means of both clinical and bitewing x-rays control after 6 and 12 months.
    


Intervention name(s): High Cost; Low Cost
Intervention type(s): Other; Other
Intervention description(s): Surfaces allocated to this group will be treated with a high-cost glass ionomer cement restoration (Fuji IX, GC America, USA), according to the manufacturer's instructions.; Surfaces allocated to this group will be treated with a low-cost glass ionomer cement restoration (Maxxion R, FGM, BRA), according to the manufacturer's instructions.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Tooth, Deciduous; Dentition, Permanent; Dental Atraumatic Restorative Treatment; Glass Ionomer Cements; Dental Caries
Efficacy and Significance of Antiviral Therapy for Unresectable Hepatitis B Virus-related Primary Liver Cancer
Condition: Primary Liver Cancer
MeSH terms: Hepatitis B; Liver Neoplasms; Hepatitis
Study type: Interventional

Summary: 
      This study is working to research the efficacy and significant of the anti-virus therapy in
      the unresectable Hepatitis B virus (HBV) related primary liver cancer(PLC) so as to establish
      treatment standards of anti-virus therapy in PLC.
    

Detailed description: 
      primary liver cancer(PLC)is one of the world's most common malignancies, especially in
      East-Asian countries.Hepatitis B virus (HBV) infection is associated with 70-90% of PLC cases
      in China. PLC can develop during any stage of the natural course of chronic HBV infection and
      anti-virus therapy should be considered during the management of PLC. However, there is no
      definite guide on when or how to practice the anti-virus therapy, especially in unresectable
      or inoperable PLC. Because of these facts, research on the significant of the anti-virus
      therapy in the HBV-related PLC is urgently needed.

      200 patients will be randomly assigned to anti-virus therapy group and control gruop.The time
      to progression(TTP) and overall survival within two years will be used to evaluate the effect
      of anti-virus therapy on PLC.

      The aim of this study is to research the efficacy and significant of the anti-virus therapy
      in the unresectable HBV-related PLC so as to establish treatment standards of anti-virus
      therapy in PLC.
    

Intervention name(s): Entecavir; conventional therapy
Intervention type(s): Drug; Drug
Intervention description(s): Entecavir 0.5mg per day; conventional therapy including protecting the liver function, anti-tumor and so on
Other intervention name(s): anti-virus group; control group
Intervention MeSH terms: Entecavir
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: primary liver cancer; hepatitis B virus; anti-virus therapy
Factors Associated With Full Recovery After Surgical Repair of Shoulder Instability
Condition: Chronic Instability of Joint
MeSH terms: Joint Instability
Study type: Interventional

Summary: 
      Case control study to evaluate different factors (e.g muscle strength, psychological factors)
      that are associated with full recovery and functional status 6 months after surgical repair
      of shoulder instability.
    

Detailed description: 
      In this study the investigators will try to find correlations between different factors and
      functional abilities of patients 6 months post shoulder surgery.

      Patients will be examined in a single encounter for muscle strength, fear avoidance beliefs
      and functional abilities.

      Functional abilities will be examined using two validated questionnaires:

        1. The Western Ontario Shoulder Instability index (WOSI)

        2. Disabilities of the Arm, Shoulder and Hand (DASH)

      Fear avoidance will be evaluated using the Fear Avoidance Belief Questionnaire (FABQ)

      Muscle strength of the rotator cuff muscles will be measured using Biodex Isokinetic system,
      model 4.
    

Intervention name(s): Questionnaires; Isokinetic Strength Measurement
Intervention type(s): Other; Device
Intervention description(s): Patients will fill self-reported functional shoulder scales (1. Western Ontario Shoulder Instability index - WOSI, and 2. Disabilities of Arm, Shoulder and Hand questionnaire - DASH), as well as a Fear Avoidance Belief Questionnaire (FABQ).; Isokinetic strength will be measured using a Biodex Isokinetic System 4.0 (Shirley, NY)
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Screening