bioihbjkbjnl/mcl2 huggingface dataset:
Treatment of Crowding Without Extraction Using Self Ligating Brackets
Condition: Crowding
Study type: Interventional

Summary: 
      This experimental study will evaluate the effect of active and passive self-ligating brackets
      in treatment of crowding, compared with the control group of conventional brackets in class I
      malocclusion without extraction.

      The study sample will consist of 66 patients with 3-6mm crowding. The sample will be
      allocated randomly into two experimental groups, in addition to a control group.

      The brackets will be applied using indirect bonding method for all patients. The
      dentoalveolar changes occurring after leveling and alignment teeth will be assessed by using
      CBCT radiographs; pre and post- treatment changes for each group will be evaluated
      individually.
    

Detailed description: 
      Producing of modern and various brackets systems both self- ligating and conventional make
      the 3 dimensional important in order to evaluate the root positions and to investigate EARR
      in multi root teeth, so the research will depend on CBCT to carry out these purposes in our
      study. Beside to compare the duration of alignment among groups.

      Fixed appliances will be applied into three groups as 1. Active self ligating brackets
      (ASLB), 2. Passive self ligating brackets (PSLB), 3. Conventional brackets (CB) until reach
      to wire 19*25 S.S upper and lower. During leveling, thermal activated wires will be used in
      all patients.

      CBCT images will be done before and after leveling and alignment of teeth to compare
      dentoalveolar changes between study groups.
    

Intervention name(s): Traditional brackets; Active self-ligating brackets; Passive self-ligating brackets
Intervention type(s): Device; Device; Device
Intervention description(s): Treating of crowding using traditional brackets; Treating of crowding using active self-ligating brackets; Treating of crowding using passive self-ligating brackets
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Crowding; Self ligating; CBCT; RCT
Montelukast Compared With Placebo and Salmeterol in Exercise-Induced Bronchoconstriction (0476-316)
Condition: Asthma, Exercise-Induced
MeSH terms: Asthma, Exercise-Induced
Study type: Interventional
Phase: Phase 3

Summary: 
      To determine the effect of an approved medication being studied in support of a new approach
      in the prevention of exercise-induced asthma (a worsening of asthma caused by exercise, also
      known as exercise-induced bronchospasm), in patients who have a history of worsening asthma
      after exercise.
    


Intervention name(s): Comparator: Montelukast; Comparator: Salmeterol; Comparator: Placebo (montelukast); Comparator: Placebo (salmeterol)
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): 1 dose montelukast 10 mg tablet given orally in one of three treatment periods; 1 dose of 50 ug salmeterol given by inhalation in one of three treatment periods; 1 dose matching-image placebo to montelukast tablet in two of three treatment periods; 1 dose matching-image placebo of salmeterol 50 ug inhalation in two of three treatment periods
Intervention MeSH terms: Salmeterol Xinafoate; Montelukast
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Parenting Mindfully Study
Condition: Substance Abuse; Risk Behaviors
MeSH terms: Substance-Related Disorders
Study type: Interventional

Summary: 
      The goal of study is to develop and test a parenting-focused version of mindfulness
      intervention ("Parenting Mindfully") to reduce parent stress and prevent adolescent substance
      use and HIV risk behaviors (e.g., risky sex). The investigators hypothesize that Parenting
      Mindfully (PM) will decrease prevent adolescent substance use and HIV risk behaviors and
      intentions. Secondarily, PM will improve parenting, and decrease adolescent stress responses.
    


Intervention name(s): Parenting Mindfully Program; Parent Education Program
Intervention type(s): Behavioral; Other
Intervention description(s): see Arm Description.; See Arm Description.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Adolescence; Substance abuse; Mindfulness
n-3 Fatty Acids in Enteral Formula on NK Cell Activity
Condition: Enteral Nutrition
Study type: Interventional

Summary: 
      The aim of our study was to investigate the NK cell activity alternations and related
      cytokine changes in comparison with soybean oil used formula (control) and the canola and
      flaxseed oil used n-3 fatty acid enriched formula (n3EN, test) with non-surgical hospitalized
      patients for rehabilitation.
    

Detailed description: 
      Patients were randomized to receive one of two types of enteral nutrition formula: soybean
      oil used enteral nutrition (control), vegetable (canola, flaxseed) derived n-3 fatty acid
      enriched enteral nutrition (n3EN). Blood samples were collected on the first day and 14 days
      after consumption of each formula and anthropometric parameters were collected. Hematology
      and biochemical values were analyzed and NK cell activities and serum cytokine productions
      were measured.
    

Intervention name(s): vegetable (canola, flaxseed) derived n-3 fatty acid; soybean oil
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): vegetable (canola, flaxseed) derived n-3 fatty acid was used for fat source.; soybean oil used formula
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Clinical Trial to Compare the Efficacy of a Fluoride Gel and a Dental Bonding Agent in Treatment of Tooth Sensitivity
Condition: Dentin Sensitivity
MeSH terms: Dentin Sensitivity; Hypersensitivity
Study type: Interventional

Summary: 
      This study compares the efficacy of two dental interventions in the treatment of cervical
      dentine sensitivity. The participants will be selected from adult dental patients registered
      at a general dental practice in West Sussex, UK. The participants will be split into 2
      groups. One group will receive the intervention of topical fluoride varnish application while
      the other group will receive a topical application of self-etching dentine bonding agent.
    

Detailed description: 
      Topical Fluoride Varnish(TFV) and Self-Etching Dentine Bonding Agent (SEDBA) are both
      routinely used in dentistry in the management of cervical dentine sensitivity(CDS). Both
      interventions are topically applied and well tolerated by patients. The interventions differ
      in mechanism of action. TFV releases fluoride which is incorporated into the organic matrix
      of dentine making the dentine tubules less conductive. Dentinal tubules form the key conduit
      between stimulus and pain perception in the tooth. SEDBA differs in that it penetrates and
      occludes the tubules. It is light cured for an almost instant set time.
    

Intervention name(s): Colgate Fluoride Varnish Suspension. 2.26% Sodium Fluoride.; Self-etching Dentine Bonding Agent
Intervention type(s): Procedure; Procedure
Intervention description(s): Topical application to exposed dentine on one occasion.; Topical application to exposed dentine on one occasion followed by light-curing procedure.
Other intervention name(s): Duraphat Varnish; Scotchbond Universal
Intervention MeSH terms: Listerine; Fluorides; Sodium Fluoride; Fluorides, Topical
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Omnipod® 5 Automated Insulin Delivery System in Patients With Type 2 Diabetes
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      The study subjects will be separated into 2 groups, depending on their previous insulin
      therapy with approximately 50% of subjects from each group, continuous glucose monitoring
      (CGM) naive.

      Group A will complete a 2-week Standard Therapy Phase followed by 8 weeks of Omnipod 5 system
      use.

      Group B will complete a 2-week Standard Therapy Phase followed by 10 weeks of Omnipod 5
      system use.

      Group A and Group B will have an optional 6-month extension of Omnipod 5 system use
    

Detailed description: 
      Basal-Bolus - Group A (N=12)

        -  2 weeks standard therapy - using multiple daily injections (MDI) and Dexcom G6
           continuous glucose monitoring (CGM) , followed by:

        -  4 weeks Omnipod 5 system use in Automated Mode with optional bolus, followed by:

        -  4 weeks Omnipod 5 system use in Automated Mode with simplified bolus

        -  6-month optional extension using Automated Mode

      Basal - Group B (N=12)

        -  2 weeks standard therapy - using basal injection only and Dexcom G6 continuous glucose
           monitoring (CGM) , followed by:

        -  2 weeks Omnipod 5 system use in Manual Mode with Dexcom G6 continuous glucose monitoring
           (CGM) - with fixed basal rate, no bolus, followed by:

        -  4 weeks Omnipod 5 system use in Automated Mode with optional bolus, followed by:

             -  If % time in range 70-180 mg/dL during Automated Mode is ≤50%, 4 weeks Omnipod 5
                system use in Automated Mode with simplified bolus, OR

             -  If % time in range 70-180 mg/dL during Automated Mode is >50%, 4 weeks Omnipod 5
                system use in Automated Mode with optional bolus

        -  6-month optional extension using Automated Mode
    

Intervention name(s): Omnipod 5 Automated Insulin Delivery System
Intervention type(s): Device
Intervention description(s): The Omnipod 5 is a single hormone insulin delivery system intended for the management of diabetes in persons requiring insulin. Continuous subcutaneous insulin infusion may be delivered by user-defined settings (manual mode) or automatically adjusted in response to feedback from a continuous glucose monitor (CGM).
The Omnipod 5 can automatically increase insulin delivery based on sensor glucose values from the continuous glucose monitor (CGM) and can decrease or suspend delivery of insulin when the glucose value falls below or is predicted to fall below predefined threshold values.
The Omnipod 5 is designed to assist patients with diabetes in achieving glycemic targets set by their health care providers.
Intervention MeSH terms: Insulin
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: T2D; Omnipod
Applying Social Comparison Theory to Behavioral Weight Loss: Does Modifying Group Membership Improve Outcome?
Condition: Obesity
MeSH terms: Weight Loss
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether a modified behavioral treatment for weight
      loss that includes one-on-one treatment for individuals struggling to lose weight is
      associated with more weight loss than a standard behavioral treatment.
    


Intervention name(s): Standard behavioral treatment for weight loss; Modified behavioral treatment for weight loss
Intervention type(s): Behavioral; Behavioral
Intervention description(s): A 24-week intervention in which individuals will meet weekly to be instructed on behavioral change associated with weight loss, including modifying dietary intake, self-monitoring weight and eating behaviors, and increasing physical activity.; A 24-week intervention in which individuals will meet weekly to be instructed on behavioral change associated with weight loss, including modifying dietary intake, self-monitoring weight and eating behaviors, and increasing physical activity. In this intervention, individuals not meeting weight loss goals will be given one-on-one treatment.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Evaluation of Adhesion Quality and Irritation of an Alternate Second Generation Estradiol Transdermal System
Condition: Healthy
MeSH terms: Tissue Adhesions
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective of this study was to compare the adhesive quality of the current Mylan
      estradiol placebo transdermal system, with that of an alternate second generation Mylan
      estradiol placebo transdermal system following a single system application. As a secondary
      objective, primary dermal irritation was assessed after removal of each transdermal system.
    


Intervention name(s): Estradiol Transdermal System Placebo - Alternate Adhesive; Estradiol Transdermal System Placebo - Current Adhesive
Intervention type(s): Drug; Drug
Intervention description(s): single application; single application
Intervention MeSH terms: Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol; Polyestradiol phosphate
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Performance of NER1008 Enema Compared With Fleet® Enema in Bowel Cleansing
Condition: Colorectal Cancer
MeSH terms: Colorectal Neoplasms
Study type: Interventional

Summary: 
      In order for flexible sigmoidoscopy to be a successful screening procedure, the bowel must be
      free of solid matter so the endoscopist has a clear view, increasing the chance of detection
      of abnormalities. This is achieved through the use of bowel cleansing preparations, which are
      administered prior to the procedure. Enemas are the preferred method as they clear the lower
      bowel more quickly than oral formulations and do not require dietary restrictions.

      The medical device being tested in this clinical investigation is NER1008, an enema which
      contains PEG3350 (polyethylene glycol 3350). PEG3350 is an osmotic agent, which holds the
      water content in the rectum and sigmoid colon, consequently increasing stool volume,
      resulting in rectal distension and subsequent distal colon emptying. The increased colonic
      luminal content stimulates the motility, propulsive transportation and rectal evacuation of
      the distal colon content.

      This study is designed to assess the performance of NER1008 in bowel cleansing and compare
      this with the performance of Fleet® enema, which is widely used for this purpose.
    


Intervention name(s): NER1008 enema; Fleet
Intervention type(s): Device; Drug
Intervention description(s): NER1008 enema administered to cleanse the bowel bewteen 1 and 3 hours prior to flexible sigmoidoscopy; Fleet enema administered to cleanse the bowel bewteen 1 and 3 hours prior to flexible sigmoidoscopy
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Screening
The Effect of Consuming Enzymes and Prebiotics on Body Composition and Blood Biochemical Index
Condition: Gut Microbiota
Study type: Interventional

Summary: 
      To assess the effects of consuming enzymes and prebiotics on improvement of weight loss and
      biochemical parameters
    


Intervention name(s): normal diet; weight loss program kit; weight loss program kit with A. muciniphila prebiotics
Intervention type(s): Other; Other; Other
Intervention description(s): Control; Subjects should adhere to the eating plan, which contained the following kit components : four flavors of collagen drinks [i.e., Caviar Collagen Enzyme Drink, Collagen Enzyme Drinks (Peach Taste), Collagen Enzyme Drinks (Grape Fruit Taste), Saussurea involucrata Enzyme Drink (Litchi Taste)], six flavors of mike shakes (i.e., Corn Soup Mike Shake, Strawberry Mike Shake, Chocolate Mike Shake, Vanilla Mike Shake, Banana Mike Shakes, Matcha Mike Shakes), Fruit and Vegitable Congee, and Botanical Liquid Sachet.; Subjects should adhere to the eating plan, which contained the following kit components : four flavors of collagen drinks [i.e., Caviar Collagen Enzyme Drink, Collagen Enzyme Drinks (Peach Taste), Collagen Enzyme Drinks (Grape Fruit Taste), Saussurea involucrata Enzyme Drink (Litchi Taste)], six flavors of mike shakes (i.e., Corn Soup Mike Shake, Strawberry Mike Shake, Chocolate Mike Shake, Vanilla Mike Shake, Banana Mike Shakes, Matcha Mike Shakes), Fruit and Vegitable Congee, Botanical Liquid Sachet, and Probiotics Liquid Sachet
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Anthropometric index; Biochemical items
The Effectiveness of Telerehabilitation in Improving Upper Extremity in Parkinson's Patients
Condition: Parkinson Disease
MeSH terms: Parkinson Disease
Study type: Interventional

Summary: 
      Parkinson's Disease (PD) is a disease that affects the functional skills of the upper
      extremity with clinical findings such as bradykinesia, rigidity, and hypokinesia and causes
      limitations in the daily life activities of the patients. Task-oriented training (TOT) is a
      highly individualized, client-centered, occupational therapy, functional-based intervention
      compatible with motor learning and motor control principles such as intensive motor training,
      variable practice, and intermittent feedback. Few studies have been found on the TOT of the
      upper extremity in PD. Telerehabilitation of Parkinson's patients shows many strengths, such
      as cost-related and time-dependent ease, and the possibility of telecommunication with
      clinicians. In addition, the refinement of digital health solutions with the goal to offer a
      patient-tailored intervention remains an ongoing process. There are a limited number of
      studies on TOT and telerehabilitation of the upper extremity in PD. In addition, no studies
      have been found applying TOT through telerehabilitation. For this purpose, a study including
      TOT-based telerehabilitation in upper extremity education in PD was planned.
    

Detailed description: 
      This study is a randomized controlled study. The patients will be randomly divided into two
      groups as exercise and control. Balance and walking exercises consisting of 3 days a week for
      6 weeks will be given to both groups as a home program. In addition, the exercise group will
      receive TOT-based telerehabilitation via video conferencing 3 days a week for 6 weeks. TOT
      will be formed from daily life activities such as reaching out, grasping, writing, and manual
      skills, which are frequently used in daily life. As the outcome measures, disease severity
      and disability, finger and hand function, hand strength, and quality of life will be
      evaluated.
    

Intervention name(s): Exercise
Intervention type(s): Other
Intervention description(s): Both groups will receive exercise-based training
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Two groups as exercise group and control group
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Parkinson Disease; Telerehabilitation; Task-oriented; upper extremity
Cue-Reward Learning and Weight Gain in Youth
Condition: Overweight; Obesity
MeSH terms: Overweight; Weight Gain
Study type: Observational

Summary: 
      The objective of the study is to compare children at low risk for obesity (two healthy weight
      parents) to children at high risk for obesity (two overweight parents) in their response rate
      to food taste and in their rate of learning using fMRI.
    

Detailed description: 
      The primary aim of this project is to conduct an adequately powered study that compares
      children at low risk for obesity to children at high risk for obesity on their brain
      responses to food tastes during a pavlovian learning task. Seven assessment visits will be
      conducted at three separate time points; baseline, 1-year follow up, and 2-year follow up.
      Assessments will include anthropometry, interviews, computer tasks, questionnaires, and an
      fMRI scan. This program of research tests a novel hypothesis regarding overeating and the
      development of obesity in children, and could provide critical data on individual
      vulnerabilities to overeating for further research. Furthermore, this study could provide
      mechanisms for intervention with regards to cue-reward learning in children, to ultimately
      prevent obesity in youth.
    

Intervention name(s): Functional MRI
Intervention type(s): Other
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Healthy-weight children (5-75thBMI%) between the ages of 8 and 11 years old with either two
        over-weight parents (BMI>25) or two healthy-weight parents (BMI = 18-24.9)
      
Keywords: Overweight; Obesity; Body Mass Index; Weight; Brain imaging; Child; Learning
Methadone Induced Memory Retrieval-extinction Procedure in Heroin Addicts
Condition: Heroin Dependence
MeSH terms: Heroin Dependence
Study type: Interventional

Summary: 
      The study assessed the efficacy of a methadone-induced memory retrieval-extinction procedure
      on heroin craving and relapse. Male participants aged 18-55 years old and prescribed MMT to
      treat heroin dependence were included in the present study, and randomly assigned to receive
      methadone, or receive methadone plus 10 minutes plus extinction, or receive methadone plus 6
      hours plus extinction. The intervention persisted 3 times per week for 4 weeks. Then the
      subjects were followed up once a month for cue induced heroin craving and relapse.
    

Detailed description: 
      In the present study, we explored the effect retrieval-extinction procedure on heroin craving
      and relapse in heroin addicts using the methadone (a commonly used µ-opioid receptor agonist)
      instead of heroin as the trigger to reactivate drug memories. The subjects were randomly
      divided into 3 groups, in which they received methadone alone or extinction sessions 10 min
      or 6 hours after methadone administration. The extinction sessions were given 3 times per
      week for 4 weeks, each lasted for 30 min. During the extinction procedure, the subjects were
      exposed to images, heroin paraphernalia and mimic heroin. Subjective craving, morphine urine
      test and physiological responses were recorded monthly for 4 months.
    

Intervention name(s): methadone induced memory retrieval-extinction procedure
Intervention type(s): Behavioral
Intervention description(s): Drug memory is not invariably stable and can be induced transiently labile again by drug-related cues or drug itself, which is termed as 'reconsolidation'. Previously we and other groups have demonstrated that extinction coincided with reconsolidation weakened the drug memory and decreased drug craving and relapse. In the present study, we tried to interfere the methadone-induced heroin addiction memory reconsolidation by extinction given at different times following methadone administration.
Intervention MeSH terms: Methadone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment