bioihbjkbjnl/mcl2 huggingface dataset:
Uphold Versus Robotic Surgery for Pelvic Prolapse Repair: A Decision Analytic Approach
Condition: Pelvic Organ Prolapse
MeSH terms: Prolapse; Pelvic Organ Prolapse
Study type: Observational

Summary: 
      Within the general objective of investigating optimal medical techniques for pelvic prolapse
      repair, this study proposes to: (1) test the hypothesis that the UPHOLD procedure is more
      cost effective than robotic surgery for pelvic prolapse repair (2)using formal decision
      analysis as the comparative strategy
    

Detailed description: 
      The cumulative incidence of pelvic organ prolapse was approximately 2% in 2001. Given the
      aging demographics in the U.S., the incidence of prolapse is projected to increase to 30% or
      more for women aged 60 years and older and become of greater concern to both patients and
      physicians. The demand for gynecologic services is predicted to increase by more than 45% in
      the next ten years. Prolapse is related to childbirth, aging, defects in collagen, and smooth
      muscle structure and strength. Etiology includes intra-abdominal pressure from obesity, with
      obesity becoming an ever increasing factor in the US.

      Treatment Choice of Patients:

      Patients choose between pessary, surgery, and expectant management based on: age, prior
      prolapse surgery, preoperative pelvic pain scores, and pelvic organ prolapse severity. These
      are difficult decisions for patients.

      When it comes to choosing between destinctive interventions with subtle advantages and
      disadvantages, patients typically want to hear their physician's views of the scientific
      merits of each procedure. Informed consent becomes extremely difficult when issues of
      cost-effectiveness are at hand. Thus, the proposed project.
    

Observational model: Other
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        20 patients who underwent either robotic surgery or the UPHOLD procedure to treat pelvic
        organ prolapse from 2009-2010
      
Keywords: UPHOLD; robotic surgery; decision analysis; FDA; decision node; outcome node
The Relationship Between Postoperative Oxygenation and STOP-BANG Questionnaire and 4-V Tool
Condition: Hypoxia; Bariatric Surgery
MeSH terms: Hypoxia
Study type: Interventional

Summary: 
      In our study, we aimed to investigate the relationship between STOP-BANG and 4-Variable
      Screening questionnaires in postoperative period in patients who underwent bariatric surgery.
    


Intervention name(s): hypoxia; normooxy
Intervention type(s): Procedure; Procedure
Intervention description(s): It was accepted that hypoxia developed in patients with SpO2< 92 or falling over 20% compared to preoperative values.; It was accepted that patients with SpO2 between 100-92 mmHg
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Screening
Keywords: stop-bang, bariatric surgery, obesity, hypoxia
(KIWI) Speeding up a Slow Protein for Muscle Mass With Hay Kiwifruit
Condition: Metabolism; Protein
Study type: Interventional

Summary: 
      The specific hypothesis is that the consumption of 2 Hayward green kiwifruit (containing
      actinidin protease) prior to 100g of ground beef will increase the rate of protein digestion
      from the beef in the elderly, leading to an increased uptake of the essential amino acids.
      Furthermore, this increased essential amino acid availability will produce a greater
      postprandial net anabolic protein response, as well as increased fractional synthetic rates
      of muscle proteins.
    

Detailed description: 
      The specific hypothesis is that the consumption of 2 Hayward green kiwifruit (containing
      actinidin protease) prior to 100g of ground beef will increase the rate of protein digestion
      from the beef in the elderly, leading to an increased uptake of the essential amino acids.
      Furthermore, this increased essential amino acid availability will produce a greater
      postprandial net anabolic protein response, as well as increased fractional synthetic rates
      of muscle proteins.

      To test this hypothesis, the investigators will use a double-blinded crossover design
      involving two intervention arms; in both arms 100g of ground beef (cooked weight) will be
      consumed following either 2 Hayward green kiwifruit (containing actinidin protease) or 2
      Hort16A Gold kiwifruit (devoid of actinidin protease) by elderly subjects.
    

Intervention name(s): Green Hayward Kiwifruit first, then Gold Kiwifruit; Gold Kiwifruit First, then Green Hayward Kiwifruit
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Subjects ate 2 peeled green kiwifruit with their midday meal for 2 weeks prior to testing.; Subjects ate 2 peeled gold kiwifruit with their midday meal for 2 weeks prior to testing.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Subjects crossed over between ingesting 2 different types of kiwifruit for 2 weeks prior to each stable isotope metabolic study.
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
Evaluate the Effects of Repeated Periods of Modified Fasting to Support Healthy Natural Weight Management and Prevention of Weight Gain
Condition: Body Weight Changes
MeSH terms: Body Weight; Weight Gain; Body Weight Changes
Study type: Interventional

Summary: 
      The purpose of this study is to assess the effects of repeated periods of modified fasting in
      support of healthy weight management and prevention of weight gain over the winter holiday
      period (mid-November to early January) in comparison to regular diet and activity.
    

Detailed description: 
      This study is a randomized, placebo-controlled trial in which subjects assigned to the
      modified fasting cohort will undergo consecutive weekly cycles of modified fasting for two
      consecutive days.

      The primary objective is to assess the effects of repeated periods of modified fasting on
      body weight.

      The secondary objectives include assessment of the effects of modified fasting on percent
      body fat, waist circumference and fasting levels of hs-CRP (hs-C-reactive protein), IL-6
      (Interleukin-6), IL-8 (interleukin-8), IL-12 (interleukin-12), TNF-a (tumor necrosis
      factor-alpha), IGF-1 (insulin-like growth factor 1), IGFBP-1 (insulin-like growth
      factor-binding protein 1) , Total Cholesterol, LDL cholesterol, HDL cholesterol, Glucose,
      Triglyceride, Insulin, Vitamin-D, 25-Hydroxy,

      Participants will undergo assessments of blood tests, vital signs, BMI, body weight, waist
      circumference and percent body fat.
    

Intervention name(s): Meal replacement shake; Multivitamin and mineral capsules; Fish oil with sesame lignans and olive extract softgel; Prebiotic Chewable tablet; Clove Extract and Maqui Berry extract capsule; .Whole Food Blend capsule; Turmeric extract capsule; European White Kidney Bean capsule; Saffron extract capsule; Ubiquinol with Fulvic acid complex softgel; Calcium with Hesperidin and gynostemma extract tablet; Multivitamin and mineral supplement
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Meal replacement shake taken two days per week during the modified fasting periods; Multivitamin/mineral supplement; Wild Fish Oil Concentrate 2000mg, Olive Extract 300mg, Sesame seed lignan extract 10mg/2 softgels; Prebiotic Fiber 1,400 mg/tablet; Clove extract 250mg and maqui berry extract 200mg/capsule; Whole food blend 1000mg/3 capsules; Turmeric 25:1 extract 400mg/capsule; White kidney bean extract 100mg/capsule; Saffron extract 88.25mg/capsule; Ubiquinol 100mg and Fulvic Acid complex 100mg/softgel; Calcium 130mg. hesperidin 500mg and gynostemma extract 450mg/ tablet; Multivitamin and multimineral supplement
Intervention MeSH terms: Calcium; Turmeric extract
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Health Services Research
Cleaning of the Nose After Sinus Surgery: Necessary or Only Bothersome?
Condition: Acute Recurrent Rhinosinusitis
MeSH terms: Sinusitis
Study type: Interventional

Summary: 
      The goal of this study is to increase knowledge about how to treat patients after sinus
      surgery.
    

Detailed description: 
      Many surgeons consider the postoperative treatment after sinus surgery as important for the
      outcome as the surgery itself. However, postoperative treatment regimes differ considerably
      between surgeons. They include non-intervention, frequent in-office endoscopic debridement,
      stenting of the middle meatus, saline douching or irrigation of the nose, or combinations of
      these measures in various ways. The lack of consensus is unfortunate. It indicates a lack of
      knowledge about how to treat these patients optimally after surgery. This is partly due to a
      lack of internationally acknowledged randomised, comparative, prospective studies on the
      effects of the various postoperative measures and their interactions. Accordingly, some
      patients may receive a too intensive postoperative follow up, with unnecessary frequent
      visits with the doctor, unnecessary bleeding and inconvenience from unnecessary
      debridement/cleaning of the nose, and increased costs due to unnecessary medication.
      Conversely, there may be patients that receive too little attention in the postoperative
      period, and thus may have a suboptimal result of the operation.

      Frequent cleaning/debridement of the nose after sinus surgery is believed to improve the
      outcome of functional endoscopic sinus surgery (FESS). However, the scientific data on its
      effects are limited. The purpose of this study was to evaluate the effects of cleaning/
      debridement of the middle meatus 5-7 days and 12-14 days after sinus surgery in a randomized,
      partly blinded, controlled clinical trial.
    

Intervention name(s): debridement or saline irrigation
Intervention type(s): Procedure
Intervention description(s): debridement of crusts, blood and secretions from the nose 1 week and 2 weeks after surgery
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Sinus surgery; endoscopic; postoperative care; debridement; randomized; acute recurrent rhinosinusitis; chronic rhinosinusitis; nasal polyps; Chronic rhinosinusitis with nasal polyps; Chronic rhinosinusitis without nasal polyps
Denosumab Related Osteonecrossi of the Jaw : : an Emergent and Potentially Complex Bone and Joint Infection
Condition: Bone and Joint Infection; Osteomyelitis; Adverse Drug Event
MeSH terms: Infections; Communicable Diseases; Arthritis, Infectious; Osteomyelitis; Drug-Related Side Effects and Adverse Reactions
Study type: Observational

Summary: 
      The aim of this study is to adescription of mandibular osteomylitis in patients having had a
      treatment by DENOSUMAB. Indeed, one of the adverse effect ot this molecule is to induce
      mandibular infection.
    


Intervention name(s): mandibular osteomylitis
Intervention type(s): Other
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        patients having a mandibular osteomylelitis due to DENOSUMAB betwwen 01/01/2013 and
        31/12/2018 and managed at the Lyon Bone and joint infection refence Center
      
Keywords: bone and joint infection; osteomyelitis; mandibular; denosumab
Therapeutic Vaccination Followed by Treatment Interruption in HIV Infected Patients
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      The aim of this trial is to find out if immune responses to HIV can be boosted in individuals
      who start medicines soon after being infected. If immune responses can be boosted to the
      virus, this may allow the body to control HIV without the need for medications. This study is
      designed to test a new strategy for boosting immune responses to HIV and to evaluate if these
      responses allow people to have control of HIV without medicines.
    

Detailed description: 
      The novel strategy used in this trial is to mix a peptide vaccine with dendritic cells from
      individuals. The dendritic cells are normal cells in the blood that boost immune responses.
      In HIV uninfected people, dendritic cells have been found to strongly activate the types of
      immune responses that may be important in controlling HIV.

      HIV infected and HIV uninfected individuals in this study will receive one shot of dendritic
      cells alone followed by three monthly shots of dendritic cells plus vaccine. We will monitor
      the immune responses to the peptide vaccine during this time period. After completing the
      vaccinations, HIV infected patients will stop their HIV medications and their immune status
      (CD4 count) and viral load will be monitored closely over 12 weeks.
    

Intervention name(s): Dendritic Cells Pulsed with HIV antigens
Intervention type(s): Biological
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Dendritic Cell; Immunotherapy; Acute HIV; Human Immunodeficiency Virus; AIDS; HIV Therapeutic Vaccine; Treatment Experienced; Treatment Interruption
Ovarian Response in Oocyte Donors Triggered With GnRH Agonists
Condition: Poor Response to Ovulation Induction
Study type: Observational

Summary: 
      The use of agonist of GnRH (aGnRH) trigger to avoid ovarian hyperstimulation syndrome is
      nowadays widely used. The action of the aGnRH in the hypophysis triggers an LH and FSH surge,
      which mimicks the natural surge that occurs in the middle of a natural cycle, and thus being
      able to elicit the ovulation. However, in some patients the aGnRH trigger ends in a poor
      oocyte recuperation, and that has led some physicians to measure the LH surge after the aGnRH
      trigger to check its effectiveness.

      Even though there is still some discrepancy about the exact cut-off value for a proper LH
      surge 12h after the aGnRH trigger, most of the published papers report the value of 15UI/L as
      an adequate threshold under which the results of the pick-up are suboptimal. Other authors
      even report a value of 52UI/L to predict a decrease in oocyte retrieval and maturity rate and
      a value of 15UI/L to predict a dramatic decrease in the results.

      Some of the abovementioned studies report that the basal LH value or the LH value on the day
      of the trigger could also be predictive of suboptimal responses. Additionally, some authors
      have tried to "rescue" the suboptimal patients with a retrigger of hCG, or they have compared
      those suboptimal responders with patients triggered with both aGnRH and low doses of hCG. In
      both cases the addition of hCG seems to improve the results.

      Most of the scientific bibliography available so far is based on infertile patients
      undergoing IVF treatments, while in some papers both IVF patients and egg donors have been
      analyzed. The current study involves exclusively oocyte donation cycles, where the final aim
      is to identify donors at a high risk of a suboptimal response, and to potentially improve
      results by potentially adding low doses of hCG (1000 UI).
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Oocyte donors included in the oocyte donation program of Clinica EUGIN
      
Keywords: oocyte donation; agonist ovulation trigger
Trial of Etoricoxib (Arcoxia) Taken Prophylactically to Prevent Ramadan Headache
Condition: Headache; Fasting; Fasting Headache; Ramadan Headache
MeSH terms: Headache
Study type: Interventional
Phase: Phase 4

Summary: 
      The investigators intend to study whether the use of the pain medication etoricoxib (Arcoxia)
      taken just before the Ramadan fast will prevent or lessen headache that some people get while
      fasting. The investigators hypothesize that etoricoxib will reduce the number of people
      getting headache, more than placebo. The investigators will do this by giving participants in
      the study either real medication or placebo (sugar pill) and comparing the results. The
      investigators will study this over two weeks. The first week one group will get the medicine
      and the other the placebo. The second the groups will switch. Neither the subjects nor the
      investigators will know who is in which group.
    


Intervention name(s): Etoricoxib; Etoricoxib; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Subjects will take etoricoxib 90mg by mouth just before the start of the daily fast. This will be for six days. After this they will receive placebo for eight days.; This arm will receive placebo just before their fast for eight days. After this they will receive etoricoxib 90mg just before their daily fast for the next six days.; Placebo
Other intervention name(s): arcoxia; Arcoxia
Intervention MeSH terms: Etoricoxib
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Keywords: Headache; Fasting; Fasting Headache; Ramadan; Ramadan Headache; Yom Kippur; Yom Kippur Headache
Progesterone for Smoking Relapse Prevention Following Delivery
Condition: Tobacco Use Disorder
MeSH terms: Tobacco Use Disorder
Study type: Interventional
Phase: Phase 2

Summary: 
      Smoking is the main preventable cause of mortality in Western countries, contributing to over
      430,000 deaths a year in the U.S. alone. Clinical and epidemiological studies show that women
      often decrease smoking in pregnancy, when progesterone levels are high. However, at least
      half resume pre-pregnancy smoking levels within weeks after delivery and when progesterone
      levels drop.

      Data from preclinical and clinical studies suggest that progesterone may be effective in
      preventing relapse to smoking in non-postpartum women. Prior work has shown that progesterone
      decreases both craving for cigarettes and the subjective rewarding effects of smoking among
      recently abstinent female smokers. These findings led us to hypothesize that progesterone may
      have efficacy as a relapse prevention treatment for postpartum women.

      We propose an 8-week, randomized pilot study to evaluate the safety and initial efficacy of
      progesterone. This will be a feasibility study that will compare progesterone to placebo for
      relapse prevention in 40 postpartum smokers. We will assess the feasibility and safety,
      including the potential effects on breastfeeding and infants exposed via breast milk, in
      addition to 7-day point prevalence of smoking abstinence after 8 weeks of treatment and at
      follow-up, 3-months after the end of the protocol.
    


Intervention name(s): Progesterone; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): oral micronized progesterone
Intervention MeSH terms: Progesterone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Progesterone; Placebo; Postpartum; Tobacco; Pregnancy
Gluten-free Diet in Patients With Primary Sclerosing Cholangitis (PSC)
Condition: Reduction of Intestinal Inflammatory Activity
MeSH terms: Cholangitis; Cholangitis, Sclerosing
Study type: Interventional

Summary: 
      Gluten is a protein found in wheat and other cereals as barley and rye. It triggers an
      inflammatory reaction in the small-bowel of genetically predisposed persons.
      Alpha-amylase/trypsin inhibitors (ATIs) of wheat seem to be the responsible trigger of this
      intestinal Inflammation.

      Intestinal inflammation is connected to other extra-intestinal autoimmune inflammations like
      PSC (as f.ex. the association of PSC with inflammatory bowel disease proves).

      Hypothesis: Avoidance of ATIs through a gluten-free diet will reduce intestinal inflammation
      and thus also the the inflammatory activity in the liver.

      Proof of hypothesis:

        -  Pilot study with n=20 patients with PSC

        -  Explorative, open-label, mono-centric study

        -  Inclusion criteria: age 18-65, diagnosed PSC-associated colitis without relevant
           clinical activity after last coloscopy.
    


Intervention name(s): Gluten-free diet
Intervention type(s): Dietary Supplement
Intervention description(s): After run-in phase with normal diet under Observation, patients will be on a gluten-free diet for two months.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of the Intensity of Continuous Renal Replacement Therapy
Condition: Optimal Intensity of Renal Replacement Therapy on Sepsis Patients
MeSH terms: Sepsis
Study type: Interventional

Summary: 
      In patients with sepsis and AKI, increasing the intensity of renal replacement therapy from
      50 mL/kg/h (HVHF) to 85 mL/kg/h (EHVHF)will increase the survival at 28 days and 90 days.
    


Intervention name(s): extra high volume hemofiltration; high volume hemofiltration
Intervention type(s): Other; Other
Intervention description(s): extra high volume hemofiltration (85 mL/kg/h, EHVHF); high volume hemofiltration (50 mL/kg/h, HVHF)
Primary purpose: Treatment
Keywords: high volume hemofiltration; sepsis; acute kidney injury; survival