bioihbjkbjnl/mcl2 huggingface dataset:
Trial to Test if Antibiotic Ointments & Cream Will Sting After Application on a Minor Wound After Tape Stripping Injury
Condition: Sting
MeSH terms: Bites and Stings
Study type: Interventional

Summary: 
      The purpose of this study is to have subjects report whether or not several antibiotic
      products sting when they are applied to minor wounds created on the inner arms.
    

Detailed description: 
      The primary objective of this study is to assess the sting potential of single applications
      of over-the-counter (OTC) topical antibiotic ointments and cream compared to saline (negative
      control) and isopropyl alcohol (positive control) when applied to a tape-stripped wound site.
    

Intervention name(s): Saline; Isopropyl Alcohol; Pain Relieving Cream; Antibiotic/Pain Relieving Ointment; Original Ointment; Pain Relief Ointment
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Other intervention name(s): Sterile 0.9% Sodium Chloride Saline Solution; 70 % Isopropyl Alcohol; Neosporin® Plus Pain Relieving Cream formula with pH balance technology; Neosporin® Complete First Aid Antibiotic/Pain Relieving Ointment; Neosporin® Original Ointment; Neosporin® Plus Pain relief Ointment
Intervention MeSH terms: Anti-Bacterial Agents; Bacitracin zinc, neomycin sulfate, polymyxin B, drug combination; Bacitracin; Neomycin; Polymyxin B; Antibiotics, Antitubercular; Ethanol
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Clinical Evaluation of Noninvasive OCT Angiography Using a Zeiss OCT Prototype to Compare to Fluorescein Angiography
Condition: Diabetic Retinopathy
MeSH terms: Diabetic Retinopathy
Study type: Observational

Summary: 
      Clinical evaluation of noninvasive OCT Angiography using a Zeiss OCT Prototype to replace
      fluorescein angiography.
    

Detailed description: 
      Fluorescein angiography (FA) is the standard and generally accepted method to identify
      vascular features in the retina, detecting capillary dropout and neovessel growth. Its value
      is undeniable and is a routine ophthalmological examination. However, it requires intravenous
      injection of fluorescein, which can cause nausea, vomiting and, rarely, anaphylaxis and
      death. New OCT angiography methods can detect, noninvasively red blood cells flow and,
      therefore, identify well the retinal vasculature. It is crucial and of major interest to
      evaluate the clinical utility of this new methodology comparing this information with the one
      obtained from fluorescein angiography.
    

Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        All patients with clinical indication for fluorescein angiography will be invited to
        perform OCT angiography in the same day during a period of 6-8 months.
Multi-Center Comparative Trial of the ASR™-XL Acetabular Cup System vs. the Pinnacle™ Metal- on- Metal Total Hip System
Condition: Non-inflammatory Degenerative Joint Disease
MeSH terms: Joint Diseases; Osteoarthritis
Study type: Interventional

Summary: 
      The primary objective of this investigation is to evaluate the clinical and radiographic
      outcomes of the ASR™-XL Acetabular Cup System compared to the Pinnacle™ Acetabular Cup with a
      28mm or 36mm ULTAMET™ metal insert.
    

Detailed description: 
      The purpose of this clinical investigation is to gather sufficient clinical and radiographic
      data to permit valid scientific comparisons between treatment and control group outcomes. The
      treatment group/device for this study is the ASR™-XL Acetabular Cup System, and the control
      group/device is the Pinnacle™ Cup System w/ the 28mm or 36mm ULTAMET™ metal liner. The study
      objective will be achieved by way of treatment group selection, treatment administration, and
      management of participating study Subjects.
    

Intervention name(s): ASR™-XL Modular Acetabular Cup System; Pinnacle™ acetabular shell
Intervention type(s): Device; Device
Intervention description(s): The ASR™-XL Modular Acetabular Cup System treatment device is comprised of a metal acetabular cup, a unipolar femoral head and a taper sleeve adapter.; The Pinnacle™ shells are cementless, titanium alloy cups with Porocoat® porous coating and HA DuoFix™ coating. There are various different liners available for use with the Pinnacle™ Acetabular Cup System. For the purpose of this investigation, the CoCrMo ULTAMET® 28mm or 36 mm metal liners will be used.
Other intervention name(s): Acetabular cup replacement; Acetabular cup replacement
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Hip arthroplasty; Acetabular cup replacement; Acetabulum arthroplasty
Music vs Relaxation Training in Craving Reduction in Alcohol Dependence Syndrome
Condition: Alcohol Dependence Syndrome
MeSH terms: Syndrome; Alcoholism; Substance-Related Disorders
Study type: Interventional

Summary: 
      The aim of the study was to compare the effectiveness of Music and Progressive Muscle
      Relaxation as interventions to reduce craving, increase coping, and understand the subjective
      experience of the interventions with patients diagnosed with Mental and Behavioral Disorders
      due to Alcohol, Dependence Syndrome, over a 5 day period.
    

Detailed description: 
      Craving for alcohol produces an aversive, uncomfortable state, with autonomic arousal similar
      to that in anxiety disorders, and is the main factor leading to relapse. Music has been shown
      to reduce anxiety and stress levels. Progressive Muscle Relaxation (PMR) is the intervention
      of choice for treatment of anxiety and related syndromes. This study aimed to compare
      efficacy of PMR and music in reducing levels of alcohol craving and increasing perceived
      ability to cope with the craving. The intervention was conducted over 5 days with two
      randomised group of 10 patients each. The patients were assigned to either group based on
      randomizer sequencing. Initial motivation was assessed before beginning the study. Measures
      of craving level and coping were collected on Day 1, 3 and 5. Single question exit interview
      was conducted to understand subjective perception of the patients regarding the techniques.
      Significant difference was found in coping levels through use of PMR (p = 0.01), and
      subjective reduction in craving levels was reported by patients in the music group, though
      this was not statistically significant. Thus, PMR may be used as an adjunct to increase
      coping abilities in patients with alcohol dependence, while music may be a useful tool to
      reduce craving but cannot be conclusively commented upon without further research.
    

Intervention name(s): Music; Progressive Muscle Relaxation
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Raga Ahir Bhairav and Bhairavi were used, played primarily on flute, without lyrics.; The instructions were recorded in both English and the local language, Kannada
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Two interventions, Music and Progressive Muscle Relaxation (PMR) were used. Music was Indian Classical Flute music, 23 minutes long. PMR was recorded for uniformity of delivery, and was 22 minutes in length.
Masking: None (Open Label)
Primary purpose: Supportive Care
Variable Approaches of Intradiscal O3-O2 Injection
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      Cost Intradiscal injection of ozone-oxygen mixture (O3-O2) which offers a rapid onset
      amelioration of symptoms, with a sustained duration pain relief in low back pain.

      Does change of injection approach make a difference?
    

Detailed description: 
      Low back pain (LBP) mostly is induced by disc herniation (DH), or degeneration and has a
      burden upon social and economic aspects of life. Medical and or surgical interventions have
      been used to resolve this problem, but one of the newly introduced is the minimally invasive
      low cost Intradiscal injection of ozone-oxygen mixture (O3-O2) which offers a rapid onset
      amelioration of symptoms, with a sustained duration pain relief.

      A lot of injection approaches are available, but which offers the best results, is the
      question.
    

Intervention name(s): Classic postrolateral extraarticular percutaneous approach for O3 injection; Postrolateral transforaminal approach (Yess approach ) for O3 injection
Intervention type(s): Procedure; Procedure
Intervention description(s): Receive 10 ml of ozone oxygen mixture 30 ug O3/ml O2 through the classic postrolateral extraarticular percutaneous approach; Group B receive 10 ml of ozone oxygen mixture 30 ug O3/ml O2 through postrolateral transforaminal approach (Yess approach ).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: low back pain , Ozone
MINVI Echocardiography Sub-Study
Condition: Birth Asphyxia
MeSH terms: Asphyxia Neonatorum; Asphyxia
Study type: Interventional

Summary: 
      Non-vigorous infants enrolled in the MINVI trial will be approached for consent for ongoing
      data collection. As part of the data collection, an optional echocardiogram will be performed
      if the parent consents.
    

Detailed description: 
      Non-vigorous infants enrolled in the MINVI trial will be approached for consent for ongoing
      data collection. As part of the data collection, an optional echocardiogram will be performed
      if the parent consents. The consent will have a check box to indicate if they consent to the
      additional test.

      Echocardiographic measurements will be performed on all infants at 12 hours +/-3 hours of age
      by our research sonographers who are blinded to infant randomization. Measurements will be
      taken according to a standard operating procedure to assess systemic blood flow, by superior
      vena cava (SVC) flow (ml/kg/min), right ventricular output (ml/kg/min), left ventricular
      output (LVO) (ml/kg/min), measures of left and right venitricular tissue Doppler and strain
      imaging. These measurements will be performed off line at a later time. Data will be entered
      into REDCap.

      If any structural abnormalities are found, the attending pediatrician will be notified of the
      abnormal echocardiogram. The consent will clearly state that this echo is not for diagnostic
      purposes. Any additional studies including an official complete echocardiogram and or
      cardiology consultation will be left to the discretion of the attending pediatrician, as
      he/she deems necessary
    

Intervention name(s): Umbilical Cord Milking; Early Cord Clamping
Intervention type(s): Procedure; Procedure
Intervention description(s): At delivery, the umbilical cord is grasped, and blood is pushed toward the infant 4 times before the cord is clamped. This procedure infuses a placental transfusion of blood into the infant and can be done in 15-20 seconds.; The umbilical cord is clamped within 30 seconds of delivery.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Cluster Randomized Crossover
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Umbilical Cord Milking; Immediate Cord Clamping; Resuscitation
Clopidogrel for Acute Ischaemia of Recent Onset
Condition: Ischemic Cerebrovascular Accident
MeSH terms: Stroke; Ischemic Stroke; Ischemia
Study type: Interventional
Phase: Phase 4

Summary: 
      Evaluate the role of loading Clopidogrel in acute ischemic stroke in improving neurological
      outcome of stroke in cases patients will be non-eligible for, or declined, treatment with or
      intravenous thrombolysis with rTPA, rTPA is not available or thrombectomy.
    


Intervention name(s): Clopidogrel; Aspirin
Intervention type(s): Drug; Drug
Intervention description(s): there is 2 groups one group will receive 900 mg Clopidogrel and the other will receive 600 mg Clopidogrel; there's another group will receive 400 mg Aspirin
Other intervention name(s): Srtoka; Aspocid
Intervention MeSH terms: Aspirin; Clopidogrel
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Staccato Granisetron® (AZ 010) for the Treatment of Cyclic Vomiting Syndrome
Condition: Cyclic Vomiting Syndrome
MeSH terms: Syndrome; Vomiting
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a multicenter, randomized, double-blind, parallel group, placebo-controlled, efficacy
      and safety study of adult outpatients diagnosed with CVS and experiencing recurring episodes
      of stereotypical vomiting.
    

Detailed description: 
      A Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Safety and Efficacy of
      Staccato Granisetron (AZ-010) for the Acute Treatment of Moderate to Severe Cyclic Vomiting
      Syndrome
    

Intervention name(s): 3mg AZ-010; 1mg AZ010; Staccato Placebo
Intervention type(s): Combination Product; Combination Product; Combination Product
Intervention description(s): Subject will receive a single inhaled dose (3mg); Subject will receive a single inhaled dose (1mg); Subject will receive a single inhaled dose (Staccato Placebo)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Cyclic Vomiting Syndrome; CVS; Vomiting; Retching; Abdominal migraine; Nausea; Stomach pain; Unexplained vomiting; Functional GI Disorder; CVSHOPE.com; Throwing up; Puking; Dry heaving; Food poisoning; Episodes; Repeated food poisoning
A Study to Evaluate the Safety and Effect of the Experimental Drugs ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 in Subjects With Chronic Hepatitis C
Condition: Chronic Hepatitis C Infection
MeSH terms: Infections; Hepatitis A; Hepatitis C; Hepatitis C, Chronic; Hepatitis; Hepatitis, Chronic
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to evaluate the safety and antiviral activity of
      ABT-450/ritonavir/ABT-267 (ABT-450/r/ABT-267; ABT-450 also known as paritaprevir; ABT-267
      also known as ombitasvir) and ABT-333 (also known as dasabuvir) with and without ribavirin
      (RBV) in patients with chronic hepatitis C virus genotype 1b (HCV GT1b) infection without
      cirrhosis.
    

Detailed description: 
      A randomized, open-label, multicenter study to evaluate the safety and antiviral activity of
      the combination of ABT-450/ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 with and without
      ribavirin (RBV) in treatment-experienced, noncirrhotic participants with chronic hepatitis C
      virus genotype 1b (HCV GT1b) infection.
    

Intervention name(s): ABT-450/r/ABT-267, ABT-333; Ribavirin
Intervention type(s): Drug; Drug
Intervention description(s): Tablet; ABT-450 coformulated with ritonavir and ABT-267, ABT-333 tablet; Tablet
Other intervention name(s): ABT-450 also known as paritaprevir; ABT-267 also known as ombitasvir; ABT-333 also known as dasabuvir; Viekira PAK
Intervention MeSH terms: Ribavirin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Hepatitis C virus; Hepatitis C Genotype 1; Hepatitis C; Interferon-Free; Chronic Hepatitis C; Ombitasvir; Ribavirin; Viekira PAK; Dasabuvir; Paritaprevir
Spiritual Intervention for Persons With Depression
Condition: Depression
MeSH terms: Depression; Depressive Disorder
Study type: Interventional

Summary: 
      Mental health is an integral part of health and depression has become a common and serious
      mental disorder. The research study aims to explore the effectiveness of spiritual
      intervention in persons with depression.
    

Detailed description: 
      This study aims to develop a community-oriented spiritual intervention programme that focuses
      on connectedness and to explore its effectiveness in persons with depression.

      Objectives:

        1. To evaluate the effect of this spiritual intervention on reducing depressive symptoms.

        2. To evaluate the effect of spiritual intervention on enhancing hope, meaning in life,
           self-esteem, and social support.

        3. To examine the moderatioon effect of demographic variables on the intervention effect in
           reducing the depressive and anxiety symptoms, and ennhancing hope, meaning in life,
           self-esteem, and social support.

        4. To examine participant's perspectives on the healing mechanisms of the intervention.

      The study is conducted as a randomized-controlled trial using a wait-list control group for
      comparison. The wait-list control group will receive the intervention after the completion of
      the post-questionnaire.

      The intervention is an 8 session weekly programme. Each weekly session is around 2 hours in
      length and the content is as below:

        1. Spirituality, mental health and depression

        2. Connectedness

        3. Forgiving and freedom

        4. Suffering and transcendence

        5. Hope

        6. Gratitude

        7. Relapse prevention and spiritual growth

        8. Wrap-up and celebration
    

Intervention name(s): Christianity approach as framework for spiritual intervention
Intervention type(s): Behavioral
Intervention description(s): Intervention includes use of Bible verses, prayer, hymns singing, sharing and caring for others (mutual support) within the group. Through these activities, participants have opportunities to re-build and further develop their connectedness to themselves, to others, to their living, their environment, and to larger meaning and purpose.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Spiritual intervention; Depression; Christian; Connectedness; randomized wait-list; community
Visilizumab for Moderate to Severe Inflammatory, Nonstricturing, Nonpenetrating Crohn's Disease
Condition: Crohn's Disease
MeSH terms: Crohn Disease
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of the study is to evaluate an intravenous (by injection) investigational
      medication to treat moderate to severe inflammatory, nonstricturing, nonpenetrating Crohn's
      disease. The research is being conducted at up to 5 clinical research sites in the US and
      Europe and is open to both men and women ages 18 to 70 years old. Participants in the study
      will have a number of visits to a research site up to 17 months. All study-related care and
      medication is provided to qualified participants at no cost: this includes all visits,
      examinations and laboratory work.

      Visilizumab is a humanized antibody (antibodies are proteins that are normally made by the
      immune system to help defend the body from infections and other foreign substances) that is
      directed against T cells. Visilizumab selectively attacks problematic T cells and, in doing
      so, it may prevent them from causing inflammation. Visilizumab has also been observed to have
      a suppressive effect on the body's immune system (system in the body that reacts to foreign
      or occasionally one's own proteins).
    

Detailed description: 
      PDL BioPharma, Inc. was formerly known as Protein Design Labs, Inc.
    

Intervention name(s): Visilizumab
Intervention type(s): Drug
Intervention MeSH terms: Visilizumab
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Continued Study of Artificial Vision: Evaluation of the BrainPort® System and Investigation of Visual Ambulation
Condition: Blindness
MeSH terms: Blindness
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the use of an artificial vision system called
      Brainport system in blind patients To investigate visual, and oculomotor (eye motion)
      mechanisms involved in the use of the Brainport system.
    

Detailed description: 
      The prevalence of blindness in the US adult population is 0.8% and ranges from about 3/10000
      to 15/10000 in children. Data from world health organization show that about 500,000 children
      become blind each year. The annual cost of blindness to the federal government is $4 billion
      and the cost of a lifetime of support and unpaid taxes for a blind person is about $1
      million.

      There is a need to restore vision for blind patients. Research on vision restoration develops
      fast. There are multiple types of approaches toward producing useful artificial vision. One
      of them directly sends images from a video camera to the visual cortex via an electrode array
      that is intracranially placed on the visual cortex of blind patients. Another one surgically
      places an electrode array beneath the retina for patients whose optic nerves are still
      healthy. Both of them require major surgery and have high risks, and neither is available for
      routine clinical application.

      The one that is non-invasive and easy to use is called the BrainPort® system. The BrainPort®
      system is manufactured by Wicab, Inc. It is commercially available and affordable to any
      consumer. This system is a novel, bionic, non-invasive, vision bypass system that conveys
      environment images from a spectacle-frame-mounted video-camera to the brain via an
      electro-tactile tongue array. The electro-tactile stimulation delivered by the tongue-array
      placed on the tongue allows users to interpret the images of objects in their camera's visual
      field.
    

Intervention name(s): BrainPort
Intervention type(s): Device
Intervention description(s): This system is a novel, bionic, non-invasive, vision bypass system that conveys environment images from a spectacle-frame-mounted video-camera to the brain via an electro-tactile tongue array. The electro-tactile stimulation delivered by the tongue-array placed on the tongue allows users to interpret the images of objects in their camera's visual field
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care