bioihbjkbjnl/mcl2 huggingface dataset:
Comparative Efficacy of 10% Potassium Hydroxide Solution Versus Cryotherapy in Molluscum Contagiosum
Condition: Molluscum Contagiosum
MeSH terms: Molluscum Contagiosum
Study type: Interventional
Phase: Phase 1

Summary: 
      A total of sixty patients presented to the outpatient dermatology department of Combined
      military hospital (CMH) Abbottabad with signs of molluscum contagiosum clinically diagnosed
      meeting inclusion criteria were enrolled. Sample size was calculated using WHO sample size
      calculator. They were divided into two groups i.e Group A and Group B using lottery method.
      Patients in Group A were subjected to cryotherapy (liquid nitrogen gas) whereas patients in
      Group B patients were subjected to 10% potassium hydroxide solution for 3 weeks and were
      followed up at 2nd, 4th, 8th and 12th week for observing the progress of therapy in both
      groups on each follow up visit and ascertaining the efficacy respectively.
    


Intervention name(s): Group A received cryotherpay; Group B received 10% Potassium Hydroxide Solution
Intervention type(s): Drug; Drug
Intervention description(s): Group A were subjected to weekly cryotherapy with a cotton stick dip ped in Liquid Nitrogen for 02 Freezes and Thaw Cycle of 07 seconds with each cycle 10 seconds apart for 3 weeks; Group B applied 10% potassium hydroxide aqueous solution twice daily with the help of a cotton tip applicator until lesion showed signs of inflammation or clearance for 3 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer
Condition: Peptic Ulcer
MeSH terms: Peptic Ulcer; Ulcer
Study type: Interventional

Summary: 
      Whether H2 receptor antagonist can prevent thienopyridine-related peptic ulcer remains
      unclear.
    

Detailed description: 
      The aim of the prospective, randomized study is investigate the efficacy of H2 receptor
      antagonist in prevention of thienopyridine-related peptic ulcer and gastrointestinal bleeding
      in patients with an ulcer history. We plan to enroll 236 thienopyridine (clopidogrel or
      ticlopidine) users with a peptic ulcer history who don't have baseline gastroduodenal ulcers
      at initial endoscopy . The patients will be randomly assigned to receive either (1)
      famotidine (40 mg qd) plus thienopyridine used previously or (2) placebo plus thienopyridine
      treatment alone for 6 months. The ulcer recurrence rate between the treatment gruops will be
      compared.
    

Intervention name(s): histamine-2 receptor antagonist; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): famotidine 40 mg qd plus thienopyridine; placebo plus thienopyridine
Other intervention name(s): famotidine 40 mg qd
Intervention MeSH terms: Famotidine; Histamine H2 Antagonists; Histamine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: histamine-2 receptor antagonist; peptic ulcer; thienopyridine; prevention
Pharmacokinetics, Safety, Tolerability and Efficacy of Intravenous Doses of ZGN-433 in Obese Female Volunteers
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to assess whether multiple doses of ZGN-433 are safe and
      effective.
    

Detailed description: 
      This protocol is designed to test the safety and efficacy of a drug called Beloranib
      (ZGN-433). It is to be tested for its ability to reduce weight in obese female subjects who
      are of non-childbearing potential. The study will provide information on how much ZGN-433
      gets into the blood, how long it stays in the body, and how it affects other biological
      markers.
    

Intervention name(s): ZGN-433; Normal Saline
Intervention type(s): Drug; Drug
Intervention description(s): Subjects will receive placebo or ZGN-433 twice-weekly over a 4-week treatment period for a total of 8 doses. A range of doses will be evaluated.; Subjects will receive placebo or ZGN-433 twice-weekly over a 4-week treatment period for a total of 8 doses. A range of doses will be evaluated.
Other intervention name(s): Beloranib
Intervention MeSH terms: CKD732
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Obese; Obesity; Overweight
Targeted Screening of At-Risk Adults for Acute HIV-1 Infection
Condition: HIV
MeSH terms: Infections
Study type: Interventional

Summary: 
      In this research, the investigators want to see if early detection of HIV infection can be
      improved by testing young adults who seek urgent health care from pharmacies and healthcare
      facilities with symptoms similar to those people get with recent HIV infection.

      Specific objectives:

        1. What proportion of people presenting with these symptoms are HIV positive at the point
           of seeking urgent health care?

        2. What proportion of those who test negative or where the result is unclear (one rapid
           test positive and one negative) at first rapid HIV testing, will test positive two weeks
           later?

        3. What is the best way (SMS, phone call or home visit) to remind people to come for the
           second test after two weeks?

        4. Will young adults who seek urgent health care for fever, body pains, diarrhoea or an STD
           from pharmacies or health facilities find it acceptable to be invited for an HIV-1 test
           at the time of health care seeking?

      Hypotheses

        1. Targeted screening for AHI among patients seeking health care for symptoms compatible
           with AHI or sexually transmitted disease (STD) will identify AHI cases in more than 1%
           of those screened.

        2. Intense follow-up of patients evaluated for AHI will improve rates of repeat HIV-1
           testing 2-4 weeks after initial health-care seeking, relative to standard practice
           (i.e., recommendation to return for testing on a given date).
    


Intervention name(s): intense follow up
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: HIV-1; acute; diagnosis; pharmacies; healthcare facilities
Breathing and Relaxation Exercises for Asthma: a Randomised Controlled Trial
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional

Summary: 
      All patients on the GP asthma database in one practice were invited for an asthma
      physical-therapy assessment, at baseline. Volunteers satisfying the inclusion criteria ie -
      aged between 16 and 70, able to understand, read and write English, give informed consent,
      willing to attend the surgery to take part in the trial and with no other serious conditions
      - were invited to participate in the study. Patients were randomised either to a control
      group, receiving 2 more assessments at 6 and 12 months, or for comparison to a group
      receiving 5 physical-therapy treatments of integrated breathing and relaxation exercises
      (known as the Papworth Method (PM)). The two groups would then be compared at 6 and 12
      months.

      Hypotheses:

        1. The PM of breathing and relaxation training would improve the quality of life for adult
           patients with asthma in primary care, compared with patients only receiving usual
           medical care.

        2. Anxiety and depression, and symptoms from dysfunctional breathing would reduce compared
           with the control group.

        3. Respiratory function measurements would improve compared with the control group.
    


Intervention name(s): Breathing and relaxation exercises: the Papworth Method
Intervention type(s): Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Asthma; Randomised controlled trial; Breathing exercises; Relaxation exercises; Primary care
The Effectiveness of Multimedia Education for Patients With Type 2 Diabe Mellitus
Condition: Type 2 Diabetes Mellitus; Insulin; Education
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      A total of 72 type 2 diabetes who began insulin therapy using a pen injector participated in
      this study. The experimental (n = 36) and control (n = 36) groups received multimedia and
      regular health education program. Four structured questionnaires were used, and videotapes
      were applied to demonstrate injection skills.
    

Detailed description: 
      To explore the effectiveness of two types health education on knowledge in diabetes and
      insulin injection, skills in insulin injection, self-efficacy in insulin injection, injection
      performance rate, satisfaction with health education,nursing hours, and biophysical
      indicators among the type 2 diabetes who began insulin therapy using a pen injector.With a
      repeated measures experimental study design, a total of 72 type 2 diabetes who began insulin
      therapy using a pen injector participated in this study. The experimental (n = 36) and
      control (n = 36) groups received multimedia and regular health education program. Four
      structured questionnaires were used, and videotapes were applied to demonstrate injection
      skills.
    

Intervention name(s): multimedia health education; regular health education
Intervention type(s): Behavioral; Behavioral
Intervention description(s): The program (flat touch computer) consisted of knowledge and technology levels. Knowledge: diabetic introduction, treatment, management of hyper- and hypoglycemia, complications, and experience sharing of insulin injection by a patient group. Technology: steps of insulin injection skills and complete technology demonstration . The program contents were organized using a unit-based piecemeal teaching approach. Participants could adjust their learning pace according to individual situations and could practice injection skills using an injection mold during hospitalization. A diabetes educator has assessed the learning outcome of each participant after intervention. At the day of discharge from hospital, each participant would acquire a copy of the multimedia health education compact disc.; The traditional education program (a diabetes educator) consisted of knowledge and technology levels. Knowledge: diabetic introduction, treatment, management of hyper- and hypoglycemia, and complications. Technology: steps of insulin injection skills and complete technology demonstration.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: This study used a randomized repeated-measures experimental design. The experimental group received a multimedia health education program and the control group received a regular health education program.
Masking: Single (Outcomes Assessor)
Primary purpose: Supportive Care
Aripiprazole and Lexapro Drug Interaction Study
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this clinical research study is to learn whether aripiprazole has effect on
      the steady-state pharmacokinetics of escitalopram in healthy subjects. The safety and
      tolerability of aripiprazole and escitalopram co-administration will also be studied.
    


Intervention name(s): Escitalopram on days -7 to day 14; Aripiprazole dosed starting Day 1 to day 14: 3 days at 10 mg, 4 days at 15 mg and 7 days at 20 mg
Intervention type(s): Drug
Intervention description(s): Tablets, Oral, Escitalopram: 10 mg; Aripiprazole: 10, 15, 20 mg, once daily, 14 days.
Other intervention name(s): Abilify
Intervention MeSH terms: Aripiprazole; Escitalopram
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Keywords: Healthy Subjects
Randomized Controlled Trial for Immunogenicity and Safety Evaluation of Bivalent Types 1 and 3 Oral Poliovirus Vaccine
Condition: Poliomyelitis
MeSH terms: Poliomyelitis
Study type: Interventional
Phase: Phase 3

Summary: 
      Type 2 component of oral poliovirus vaccine is slated for global withdrawal through a switch
      from trivalent oral poliovirus vaccine (tOPV) to bivalent oral poliovirus vaccine (bOPV) for
      preventing paralytic polio caused by circulating vaccine-derived poliovirus type 2. We aimed
      to assess immunogenicity and safety profile of six vaccination schedules with different
      sequential doses of inactivated poliovirus vaccine (IPV), tOPV, or bOPV.
    

Detailed description: 
      A randomized controlled trial was conducted in China in 2015. After informed consent was
      obtained from a parent or legally acceptable representative, healthy newborn babies were
      randomly allocated to one of six groups: cIPV-bOPV-bOPV, cIPV-tOPV-tOPV, cIPV-cIPV-bOPV,
      cIPV-cIPV-tOPV, cIPV-cIPV-cIPV, and tOPV-tOPV-tOPV. The key eligibility criteria were:
      full-term birth (37-42 weeks of gestation), birthweight ≥2·5 kg, no obvious medical disorders
      and no polio vaccination. Infants received following three doses sequentially with 4- 6 weeks
      interval after collecting blood sample: cIPV-bOPV-bOPV, cIPV-tOPV-tOPV, cIPV-cIPV-bOPV,
      cIPV-cIPV-tOPV, cIPV-cIPV-cIPV, and tOPV-tOPV-tOPV; and will be proactively followed up for
      observing adverse events after the first dose and 30 days after all doses. Antibodies of type
      1, 2, and 3 poliovirus were tested 30 days after the third dose. The primary study objective
      was to investigate immunogenicity and safety profile of different vaccine schedules,
      evaluated by seroconversion, seroprotection and antibody titre against poliovirus types 1, 2,
      and 3 in the per-protocol population.
    

Intervention name(s): poliovirus vaccine
Intervention type(s): Biological
Intervention description(s): Different vaccination schedules with bOPV, tOPV and cIPV would be provided for 6 arms respectively.
Other intervention name(s): bivalent types 1 and 3 oral poliovirus vaccine; trivalent conventional inactivated poliovirus vaccine; trivalent types 1, 2 and 3 oral poliovirus vaccine
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: immunization; vaccine schedule; poliomyelitis; polio; oral polio vaccine; inactivated polio vaccine
Antioxidant Effects of Melatonin in Preterm
Condition: Newborn Morbidity; Oxidative Stress; Pre-Term; Melatonin Deficiency
MeSH terms: Premature Birth
Study type: Interventional

Summary: 
      Preterm infants are at risk of free radical mediated diseases from oxidative stress (OS)
      injury. Melatonin (MEL) is a powerful antioxidant and scavenger of free radicals. In preterm
      neonates, melatonin deficiency has been reported. Several studies tested the efficacy of
      melatonin to counteract oxidative damage in diseases of newborns such as chronic lung
      disease, perinatal brain injury, necrotizing enterocolitis, retinopathy of prematurity and
      sepsis, giving promising results. In these studies, the dosages of melatonin varied over a
      wide range. The present study was designed to test the hypothesis that oral administration of
      melatonin reduced OS and consequentially, the occurrence of intraventricular haemorrhage
      (IVH), necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP) and bronchopulmonary
      dysplasia (BPD) in preterm newborns.
    


Intervention name(s): Melatonin drops; Placebo
Intervention type(s): Dietary Supplement; Other
Intervention description(s): Melatonin oral administration; Oral 5% glucose
Intervention MeSH terms: Melatonin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Investigator)
Primary purpose: Treatment
Market Research - Acceptability Study for New MCT Fat Products
Condition: Ketosis; Epilepsy; Fatty Acid Oxidation Disorder; Malabsorption; Ketogenic Diet; Medium Chain Triglycerides
MeSH terms: Malabsorption Syndromes; Epilepsy; Ketosis
Study type: Interventional

Summary: 
      This is a market research, observational study to evaluate the tolerability and acceptability
      of MCT supplements for young children, young people and adults with intractable epilepsy,
      GLUT-1 or PDHD from 3 years to adulthood.
    


Intervention name(s): MCT fats
Intervention type(s): Dietary Supplement
Intervention description(s): Subjects will be asked to take 3 new MCT products for 7 days each over a 25 day period
Other intervention name(s): medium chain triglycerides
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
An Ascending Multiple Dose Study of CD101 IV in Healthy Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      A multiple ascending dose study to evaluate the safety, tolerability, and pharmacokinetics of
      CD101 Injection in Healthy Subjects.
    

Detailed description: 
      This is a Phase 1, single-center, prospective, randomized, double-blind study of multiple
      ascending doses (MAD) of CD101 Injection administered IV to healthy adult subjects. In this
      study, subjects in 3 cohorts of 8 subjects each will be randomized to receive multiple IV
      doses of CD101 Injection or placebo infusions. Dose levels of CD101 Injection to be assessed
      will follow an ascending multiple-dose regimen.
    

Intervention name(s): CD101 IV; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): antifungal; Normal saline
Intervention MeSH terms: Rezafungin
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Subjects
Danlou Tablets to Prevent Left Ventricular Remodeling
Condition: Left Ventricular Remodeling; Acute Myocardial Infarction
MeSH terms: Myocardial Infarction; Infarction; Ventricular Remodeling
Study type: Interventional
Phase: Phase 4

Summary: 
      Danlou tablets are Chinese patent medicine which has been approved in China for the treatment
      of ischemic heart disease, but the evidence supporting its efficacy on cardiac remodeling
      remains unclear. This pilot study was designed to determine whether Danlou tablets reduced
      adverse left ventricular (LV) remodeling in patients with acute myocardial infarction (MI).
      Patients following acute MI were enrolled and randomly allocated to Danlou tablets (4.5 g
      q.d. for 90 days) or placebo, superimposed on standard medications for the treatment of MI.
      Major end points were changes in LV volumes and ejection fractions as evaluated by serial
      echocardiography in addition to clinical outcomes were also determined.
    

Detailed description: 
      This randomized, prospective, double-blind, placebo-controlled, parallel-group clinical trial
      was performed in two institutions (Guangdong Provincial Hospital of CM and Wuyi Hospital of
      CM). The study was conducted in accordance with the Declaration of Helsinki and its text
      revisions and all participants provided written informed consent before enrollment. The
      Clinical Research Ethical Committee at Guangdong Provincial Hospital of Chinese Medicine
      approved the research protocol (B2011-41-01).

      Once eligible candidates had undergone PCI, they were admitted to the coronary intensive care
      unit and received standard treatment according to the institutional protocol based on
      American College of Cardiology/ American Heart Association and European Society of Cardiology
      guidelines.20 Simultaneously, patients were randomized assigned in a 1:1 ratio to receive
      Danlou tablets (4.5 g oral dose taken once daily) or matching placebo for 90 days according
      to a computer-generated site-stratified, block randomization schedule. Danlou tablets were
      approved by China Food and Drug Administration for the treatment of ischemic heart disease in
      2005 (Z20050244).
    

Intervention name(s): Danlou Tablets; Placebo
Intervention type(s): Drug; Other
Intervention description(s): Danlou tablets were approved by China Food and Drug Administration for the treatment of ischemic heart disease in 2005 (Z20050244).; Placebo with no chemical effects.
Other intervention name(s): Danlou
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Acupuncture Needling on Connective Tissue by Ultrasound
Condition: Healthy
Study type: Observational

Summary: 
      The purpose of this study is to investigate the effect of acupuncture needling on connective
      tissue using ultrasound techniques both in animals and in humans.
    


Observational model: Defined Population
Time perspective: Other
Keywords: connective tissue; ultrasound; acupuncture
Evaluation of PK of AC-1204 Mixed in Water, AC-1202 Mixed in Water, and AC-1202 Mixed in Ensure® on Ketone Body Production
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      To compare serum ketone body (i.e., total ketones, β hydroxybutyrate, and estimate of
      acetoacetate) levels after single dose administration of AC-1204 mixed in water, AC-1202
      mixed in water and AC-1202 mixed in Ensure®.
    


Intervention name(s): AC-1204 mixed in water; AC-1202 mixed in water; AC-1202 mixed in Ensure®
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 40 g AC-1204 (shaken in 240 mL of water) at Hour 0 on Day 1; 60 g AC-1202 (shaken in 240 mL of water) at Hour 0 on Day 1; 60 g AC-1202 (shaken in approximately 8 oz [237 mL of Ensure® Original] at Hour 0 on Day 1)
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Healthy volunteers; AC-1202; AC-1204; Pharmacokinetic; ketone body
Anthropometric, Metabolic, Cardiovascular and Symptomatic Profile in Postmenopausal Women
Condition: Postmenopausal Disorder
Study type: Observational

Summary: 
      The purpose of this study is to investigate anthropometric, metabolic, cardiovascular and
      symptomatic profiles in postmenopausal women.
    

Detailed description: 
      When aging, the body composition changes, leading to a reduction of muscle mass and strength,
      and to an increase in total body fat. These body composition changes have especially been
      observed in postmenopausal women, due to the hormonal changes taking place. After the
      menopause, the gynoid fat distribution with fat deposits in the gluteo-femoral region changes
      to an android fat distribution with an increased upper body fat, especially in the abdominal
      region. These consequences of the menopause associated with a decrease in aerobic capacity
      and reduced total energy expenditure may lead to the metabolic syndrome (MetS). The aim of
      this study was to investigate the anthropometric, metabolic, cardiovascular and symptomatic
      profile in gynoid and android postmenopausal women.
    

Intervention name(s): Clinical exams
Intervention type(s): Other
Intervention description(s): Physiological and biochemical tests; quality of life questionnaire; body composition measurement
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Postmenopausal women from a community sample of São Carlos city - São Paulo State - Brazil.
      
Keywords: Postmenopausal Women; Body Composition; Metabolic Syndrome; Menopause Symptoms