bioihbjkbjnl/mcl2 huggingface dataset:
Local Paclitaxel Delivery for SFA Disease
Condition: Atherosclerosis; Angioplasty; Peripheral Arterial Disease
MeSH terms: Atherosclerosis; Peripheral Arterial Disease; Peripheral Vascular Diseases
Study type: Interventional

Summary: 
      To see if restenosis rates of superficial femoral artery atherosclerosis with percutaneous
      techniques can be improved using paclitaxel.
    

Detailed description: 
      Treatment of superficial femoral artery atherosclerosis with percutaneous techniques is
      hindered by high restenosis rates. Paclitaxel inhibits restenosis in coronary arteries, and a
      few studies suggest it may be effective in reducing restenosis rates in peripheral arteries.
      The investigators hypothesize that delivering paclitaxel through an irrigating catheter will
      be superior in preventing restenosis.
    

Intervention name(s): Paclitaxel
Intervention type(s): Drug
Intervention description(s): Paclitaxel will be administered intra-arterially through an irrigating catheter to treat a diseased segment of superficial femoral artery. Dosing will be based on ther lesion surface area, and will be calculated using the following formula: dose= 22/7 X diameter (mm) X length (mm) X 3 micrograms/mm^3
Intervention MeSH terms: Paclitaxel
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: atherosclerosis; angioplasty; peripheral arterial disease
Conservative Versus Surgical Treatment of Impacted Femoral Neck Fracture in Patient 75 Years Old and Older
Condition: Femoral Neck Fractures
MeSH terms: Fractures, Bone; Femoral Neck Fractures
Study type: Interventional

Summary: 
      The purpose of the study is to evaluate the safety and effectiveness of conservative
      treatment in treatment of patients over 75 years with impacted femoral neck fracture.
    

Detailed description: 
      The study is to compare clinical outcomes between conservative treatment, internal fixation,
      and hemiarthroplasty in patients over 75 years with impacted femoral neck fracture. All the 3
      groups were evaluated by hip pain(visual analogue scale,VAS), hip function(Harris hip
      score,HHS), health related quality of life(European Quality of Life-5 Dimensions index
      scores, Eq-5d). All thses parameters were assessed at admission and 1-, 3-, 6- 12-, 24- and
      36 months after intervention. Operation duration and blood loss were recorded. Mortality,
      union rate, complications and re-operation were also monitored throughout the study.
    

Intervention name(s): Surgical Treatment for Impacted Femoral Neck Fracture
Intervention type(s): Procedure
Intervention description(s): Surgical Treatment for Impacted Femoral Neck Fracture
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Swedish Spinal Stenosis Study
Condition: Lumbar Spinal Stenosis
MeSH terms: Spinal Stenosis; Constriction, Pathologic
Study type: Interventional

Summary: 
      A national randomized multicentre trial (RCT) where decompression is compared with
      decompression with simultaneous fusion in 245 patients with spinal stenosis on one or two
      adjacent lumbar levels with or without degenerative olisthesis. The material is stratified
      for the existence of degenerative olisthesis >3mm. Monitoring is performed with clinical
      results from patient surveys after 2 and five years, and with radiological follow-up (MRI, CT
      and plain X-ray) and an objective function test (6 min walking test) after 2 years. The null
      hypothesis is that there is no difference in results between the two interventions.
    


Intervention name(s): Decompression without fusion; Decompression with fusion
Intervention type(s): Procedure; Procedure
Intervention description(s): Decompressive surgery of both central and lateral component of the stenosis.; Decompressive surgery of both central and lateral component of the stenosis AND concomitant instrumented or uninstrumented posterior fusion of decompressed segments.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Spinal stenosis; Decompression; Fusion; Olisthesis
Effects of Group Vs. Home-Based Combined Exercise-Diet Program In Childhood Obesity: A Randomised Controlled Trial
Condition: Obesity
MeSH terms: Obesity; Pediatric Obesity
Study type: Interventional

Summary: 
      The aim of this study was to compare the effect of a hospital group-based vs. home-based
      combined exercise-diet program for the treatment of childhood obesity.
    


Intervention name(s): Circuit training
Intervention type(s): Other
Intervention description(s): Aerobic and resistance training exercises + Mediterranean diet
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Children; Physical activity; Home-based treatment; Body mass index (z-BMI); Percentage body fat; Waist circumference
A Multiple-Dose Study of LY3502970 in Healthy Participants
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The main purpose of this study is to conduct blood tests to measure how much LY3502970 is in
      the bloodstream and how the body handles and eliminates LY3502970 in healthy participants in
      fed and fasted states. The study will also evaluate the safety and tolerability of LY3502970
      in these participants. The study will last up to 49 days excluding the screening period.
    


Intervention name(s): LY3502970
Intervention type(s): Drug
Intervention description(s): Administered Orally.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Food; Food Effect
Antineoplaston Therapy in Treating Children With Low-Grade Astrocytoma
Condition: Low Grade Astrocytomas
MeSH terms: Astrocytoma
Study type: Interventional
Phase: Phase 2

Summary: 
      RATIONALE: Current therapies for children with low grade astrocytomas that have not responded
      to standard therapy provide limited benefit to the patient. The anti-cancer properties of
      Antineoplaston therapy suggest that it may prove beneficial in the treatment of children with
      low grade astrocytomas that have not responded to standard therapy

      PURPOSE: This study is being performed to determine the effects (good and bad) that
      Antineoplaston therapy has on children (> 6 months of age) with low grade astrocytomas that
      has not responded to standard therapy.
    

Detailed description: 
      OBJECTIVES:

        -  To determine the efficacy of Antineoplaston therapy in children with low grade gliomas
           that has not responded to standard therapy, as measured by an objective response to
           therapy (complete response, partial response or stable disease).

        -  To determine the safety and tolerance of Antineoplaston therapy in children with a brain
           tumor.

      OVERVIEW: This is a single arm, open-label study in which children with low grade
      astrocytomas that have not responded to standard therapy receive gradually escalating doses
      of intravenous Antineoplaston therapy (Atengenal + Astugenal) until the maximum tolerated
      dose is reached. Treatment continues for at least 12 months in the absence of disease
      progression or unacceptable toxicity. After 12 months, patients with a complete or partial
      response or with stable disease may continue treatment.

      To determine objective response, tumor size is measured utilizing MRI scans, which are
      performed every 8 weeks for the first two years, every 3 months for the third and fourth
      years, every 6 months for the 5th and sixth years, and annually thereafter.

      PROJECTED ACCRUAL: A total of 20-40 patients will be accrued to this study.
    

Intervention name(s): Antineoplaston therapy (Atengenal + Astugenal)
Intervention type(s): Drug
Intervention description(s): Children with a low grade astrocytoma that have not responded to standard therapy will receive Antineoplaston therapy (Atengenal + Astugenal).
Other intervention name(s): A10 (Atengenal); AS2-1 (Astugenal)
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: childhood low-grade astrocytoma; recurrent childhood astrocytoma; persistent childhood astrocytoma
Attention and Achievement: A Mind Wandering Investigation
Condition: Attention Disturbances
Study type: Interventional

Summary: 
      This study assesses the impact of mind-wandering on reading and math.
    

Detailed description: 
      This study assesses the impact of mind-wandering on reading and math. Specifically 120 middle
      school student participants will receive descriptive measures (of achievement, attention and
      related factors including mind-wandering), and will receive a brief (~30 min) lesson in
      reading and math (order counterbalanced). Participants will receive a brief pre-test, the
      lesson, and then a post-test on the reading and math outcomes. 75% of the participants will
      receive a brief manipulation that sets up the influence of mind-wandering, as well as
      redirects when probe-caught mind-wandering occurs. The remaining participants will receive
      only redirects, and only randomly. Among participants to receive the mind-wandering
      manipulation, an equal number will receive this only for reading, only for math, and for both
      reading and math.
    

Intervention name(s): mind-wandering intervention; mind-wandering comparison
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Participants in this condition receive a brief introduction to the potential impact of mind-wandering (before learning, proactive), and are redirected to lesson if "probe-caught" mind-wandering are endorsed (during learning, reactive); Participants in this condition receive no introduction, and only redirection, and the redirection is random, not in reaction to mind-wandering
Allocation: Randomized
Intervention model: Factorial Assignment
Intervention model description: The factors are study condition order (reading, math), proactive and reactive mind-wandering manipulation (yes, no), and lesson target (reading, math, both, neither)
Masking: None (Open Label)
Primary purpose: Treatment
Pharmacokinetic, Safety, and Tolerability Study of Intranasally Administered Esketamine in Healthy Han Chinese, Korean, Japanese, and Caucasian Participants and the Effects of Rifampin on the Pharmacokinetics of Intranasally Administered Esketamine
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the pharmacokinetics of intranasally administered
      esketamine in healthy Han Chinese, Korean, Japanese, and Caucasian participants and to
      evaluate the effects of rifampin on the pharmacokinetics of intranasally administered
      esketamine in healthy Caucasian participants.
    


Intervention name(s): Esketamine; Rifampin
Intervention type(s): Drug; Drug
Intervention description(s): 100-mcL spray of 14% esketamine solution (14 mg) for a total dose of 56 mg.; 2 capsules (300 mg each) of rifampin.
Intervention MeSH terms: Rifampin; Esketamine
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of Different Probiotic Strains in Hypercholesterolemic Patients
Condition: Hyperlipidemias
MeSH terms: Hyperlipidemias; Hyperlipoproteinemias
Study type: Interventional

Summary: 
      Regular probiotic use for 8 weeks was evaluated in individual with mild to moderate
      hyperlipidemia. Current study have been determined the use of different probiotics strains on
      lipid parameters such as; total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride
      levels as well as glycemic parameters such as; glucose, insulin, HOMA-IR levels. Also, hs-CRP
      levels were investigated as inflammatory parameter.
    

Detailed description: 
      In the light of recent studies, it has been shown that probiotics may have positive effects
      on hyperlipidemia. The aim of this study was to investigate the effect of probiotics mainly
      on blood lipids as well as homocysteine levels, glycemic control parameters and hs-CRP levels
      A randomized, double-blind placebo-controlled study was completed with a total of 51
      individuals who have diagnosed with hyperlipidemia. Participants were randomly assigned into
      3 groups according to the probiotic type they would consume, groups were as follows;
      Lactobacillus (probiotic group I) (n=18), Lactobacillus and Bifidobacterium (probiotic group
      II) (n=17) and placebo group (n= 16). They were all requested to have placebo or probiotic
      capsules every day for 8 weeks. Total cholesterol, HDL cholesterol, LDL cholesterol,
      triglyceride levels were investigated as lipid metabolism parameters while fasting blood
      glucose, insulin, HOMA-IR levels were investigated as glycemic parameters. Also, hs-CRP
      levels were investigated as inflammatory parameter.
    

Intervention name(s): Only Lactobacillus rhamnosus GG strains; Combined Lactobacillus acidophilus and Bifidobacterium animalis subsp.lactis strains; Placebo
Intervention type(s): Dietary Supplement; Combination Product; Other
Intervention description(s): 1x106 colony forming unit (CFU) Lactobacillus rhamnosus GG probiotic capsule; combination of Lactobacillus acidophilus 1x109 CFU and Bifidobacterium animalis subsp.lactis 1x109 CFU probiotic capsule; Placebo probiotic capsule
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Double-blind randomized controlled trial
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: serum lipids; hyperlipidemia; probiotics
Study Of Tranexamic Acid For The Reduction Of Blood Loss In Patients Undergoing Surgery For Long Bone Fracture
Condition: Femoral Fractures
MeSH terms: Hemorrhage; Fractures, Bone; Femoral Fractures
Study type: Interventional
Phase: Phase 4

Summary: 
      Tranexamic acid has been shown to reduce postoperative blood losses and transfusion
      requirements in a number of types of surgery. Most trials in orthopedic surgery have been
      conducted in arthroplasty, hip fracture and spine surgeries. This study would aim to see the
      effect of tranexamic acid in reduction of blood loss and transfusions for long bone fracture
      surgery, primarily fracture shaft of femur.
    


Intervention name(s): Tranexamic Acid plus standard of care; Standard of care
Intervention type(s): Drug; Procedure
Intervention description(s): Tranexamic acid given slowly intravenously (15 mg/kg body weight) 15 minutes before surgery followed by a second dose at three hour interval from first dose and third dose at three hour interval from the second + Standard of care (Standard of care includes the routine surgical and anesthetic techniques being utilized to control blood loss); Standard of care includes the routine surgical and anesthetic techniques being utilized to control blood loss
Intervention MeSH terms: Tranexamic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Tranexamic Acid; Blood Loss; Long Bone Fracture Surgery
Head Position on Preventing Emergence Cough
Condition: Gallbladder Diseases
MeSH terms: Gallbladder Diseases
Study type: Interventional

Summary: 
      The purpose of this study is to investigate the effect of head position on prevent the
      emergence cough followed by endotracheal extubation.
    

Detailed description: 
      During endotrachl intubaion, the sniffing postion is most commonly recommended. However, the
      head position to reduce the emergence cough followed by endotracheal extubation was not
      confirmed yet. Considering the endotracheal tube vector, head elevation with pillow is
      thought to be acceptable more.
    

Intervention name(s): Head on bed; Head on pillow
Intervention type(s): Procedure; Procedure
Intervention description(s): During emergence, head is kept on bed without pillow.; During emergence, head is kept on pillow.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Prevention
German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99)
Condition: Adult Acute Lymphocytic Leukemia
MeSH terms: Leukemia; Leukemia, Lymphoid; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Study type: Interventional
Phase: Phase 4

Summary: 
      The study evaluates the efficacy and tolerability of an intensified induction and
      consolidation therapy. Thereafter patients receive individualised treatment stratified
      according to relapse risk with stem cell transplantation for patients with high and very high
      risk of relapse. Patients with standard risk receive further consolidation and reinduction
      chemotherapy. In parallel minimal residual disease (MRD) is evaluated. A MRD based risk
      stratification and treatment decision is developed.
    


Intervention name(s): Dexamethasone / Prednisolone; Cyclophosphamide; Methotrexate; Vincristine / Vindesine; Daunorubicin; Asparaginase; G-CSF; Cytarabine; 6-Mercaptopurine; VP16; Adriamycin; Thioguanine; VM26; Idarubicin; Fludarabine; Ifosfamide; CNS irradiation; Mediastinal irradiation (if residual tumor); stem cell transplantation
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Procedure; Procedure; Procedure
Intervention MeSH terms: Cytarabine; Dexamethasone; Prednisolone; Cyclophosphamide; Ifosfamide; Methotrexate; Fludarabine; Vincristine; Doxorubicin; Daunorubicin; Asparaginase; Mercaptopurine; Idarubicin; Thioguanine; Vindesine
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: ALL; Treatment; De Novo; Adult
A Study to Evaluate the Effect of MCI-186 at Therapeutic and Supra-Therapeutic Doses on the QT Interval(QT)/Corrected QT Interval(QTc) Interval in Healthy Subjects
Condition: Healthy Adult Subjects
Study type: Interventional
Phase: Phase 1

Summary: 
      To evaluate the effect of MCI-186 on the QT interval corrected for heart rate using
      Fridericia's formula (QTcF)
    


Intervention name(s): MCI-186; MCI-186; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): A single dose of 60 mg MCI-186 over 60 min will be intravenously administered.; A single dose of 300 mg MCI-186 over 60 min will be intravenously administered.; A single dose of 0.9% w/v saline over 60 min will be intravenously administered.
Other intervention name(s): Edaravone; Edaravone
Intervention MeSH terms: Edaravone
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Other
Long-term Impact Evaluation of a Worksite-based Lifestyle Intervention to Reduce Cardiovascular Risk in Office Workers
Condition: Atherosclerosis
MeSH terms: Atherosclerosis
Study type: Interventional

Summary: 
      The main objective of TANSNIP-PESA is to determine in a population of asymptomatic bank
      employees with high and low imaging defined cardiovascular disease (CVD) risk the
      effectiveness of a comprehensive 3-year worksite-based lifestyle intervention consisting of
      12 personalized lifestyle counseling sessions, a Fitbit physical activity tracker and a
      sit-stand Workstation.
    

Detailed description: 
      We will study the effectiveness of a 30-month worksite-based lifestyle program aimed to
      promote cardiovascular health in participants having a high or a low degree of subclinical
      atherosclerotic plaque burden (SAPB), compared to standard care.

      Methods: We will conduct a randomized controlled trial (RCT) including middle-aged bank
      employees from the ´Progression of Early Subclinical Atherosclerosis´ (PESA) cohort,
      stratified by SAPB. Within each stratum, participants will be randomized 1:1 to receive a
      lifestyle program or standard care.

      The primary outcome measure is the adapted FUSTER-BEWAT CVD risk and lifestyle composite
      score and secondary outcome measures include physical activity, sedentary time, standing
      time, diet, smoking, anthropometric measures, blood biomarkers, self-rated health,
      work-related outcomes, healthcare consumption, program process measures and cost measures.
    

Intervention name(s): Lifestyle intervention
Intervention type(s): Behavioral
Intervention description(s): Each participant will receive 12 personalized lifestyle counseling sessions given face-to-face by a trained practitioner.
The Fitbit physical activity tracker gives summaries of the participant's physical activity, provides stimulating prompts and rewards, and allows for social media sharing and competition.
A Sit-stand workstation allows to adjust the height of the participant workstation, including the computer screen, keyboard and mouse and allows them to easily switch between sitting and standing throughout the workday.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: Health Lifestyle; Lifestyle Risk Reduction; Health Behavior; Sedentary Lifestyle; Intervention Studies; Cardiovascular risk in office workers; Motivational Interview; Preventive health services; Health education; Physical activity; Dietary behaviour intervention; Workplace