Factors Associated With Falling in Parkinson's Disease
Condition: Parkinson Disease
MeSH terms: Parkinson Disease
Study type: Interventional

Summary: 
      The objective of this study will be to identify multidisciplinary fall risk factors in
      persons with stage 3 idiopathic Parkinson's Disease compared to age and sex-matched healthy
      adults. Both the relative contribution of each independent factor, as well as the interaction
      between these factors, will be examined. The study will include multidisciplinary
      assessments, including locomotor, speech, auditory, vestibular and opthalmologic assessments.
    


Intervention name(s): Baseline assessment of demographic, anthropometric and clinical characteristics; Baseline assessment of demographic, anthropometric and clinical characteristics; Locomotor assessments; Speech assessments; Audiology assessments
Intervention type(s): Other; Other; Other; Other; Other
Intervention description(s): Age
Sex
Height
Body weight
Handedness
Medication use
Blood pressure
Global cognition (Montreal Cognitive Assessment)
Fear of falling (Shortened Iconographical Falls Efficacy Scale)
History of falls (number of falls in the past month)
Time since diagnosis and symptom onset
Disease severity (UPDRS part III, Hoehn and Yahr)
Non-motor symptoms (UPDRS part I)
Motor symptoms (UPDRS part III)
Motor complications (UPDRS part IV)
Disease-dominant side (UPDRS part III)
Freezing of gait (New Freezing of Gait Questionnaire); Age
Sex
Height
Body weight
Handedness
Medication use
Blood pressure
Global cognition (Montreal Cognitive Assessment)
Fear of falling (Shortened Iconographical Falls Efficacy Scale)
History of falls (number of falls in the past month); First, 9 anthropometric measurements will be taken, 39 reflective markers will be placed, and a 6-min practice walking session will be conducted to familiarize participants with self-paced treadmill walking (SPTW). Thereafter, participants will partake in 7 experimental conditions in a (semi-)randomized order:
3 min standing
3 min standing while answering semi-standardized questions
3 min SPTW
3 min SPTW while answering semi-standardized questions (SPTW-Q)
3 min SPTW while verbally describing a VR environment (SPTW-VR1)
6 min SPTW in a VR environment containing freezing of gait provoking elements (SPTW-VR2); Acoustic analysis (including voice reports and formant analysis), video recording and motor speech profile (including analysis of diadochokinesis, voice, standard syllabic rate, intonation and second formant (F2)).
Spontaneous speech production will be assessed by answering semi-standardized questions based on the Aachen Aphasia Test and by describing a VR environment projected on a 180-degree cylindrical screen
The Speech Handicap Index (a 15-item self-reported questionnaire); Otoscopy
Tympanometry
Pure tone audiometry
Otoacoustic emissions
Video Head Impuls Test
Cervical Vestibular Evoked Myogenic Potentials
Ocular Vestibular Evoked Myogenic Potentials
Oculomotor function testing
Positional testing
Static visual acuity test
Dynamic visual acuity test
Dizziness Handicap Inventory (a 25-item self-assessment inventory)
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: Case-control
Masking: None (Open Label)
Primary purpose: Screening
Keywords: Parkinson's Disease; Accidental Falls; Risk factor; Gait; Speech; Audiology