bioihbjkbjnl/mcl2 huggingface dataset:
Clinical Outcomes of Angioplasty Postconditioning
Condition: Acute Myocardial Infarction
MeSH terms: Myocardial Infarction; Infarction
Study type: Interventional

Summary: 
      We previously demonstrated that postconditioning by coronary angioplasty can decrease infarct
      size (as measured by cardiac enzyme release) in patients with ongoing acute myocardial
      infarction. It is currently unknown whether postconditioning actually decreases or simply
      delays myocardial cell death during reperfusion. In addition, the long term effects of
      postconditioning on recovery of myocardial contraction remains elusive. The objective of the
      present study is to determine whether infarct size reduction by angioplasty postconditioning
      is maintained at 6 months and whether functional recovery is improved at one year
      post-infarction.
    

Detailed description: 
      Randomized, controlled, single-blinded trial comparing postconditioning to control (no
      intervention). Postconditioning consists of four episodes of one minute inflation followed by
      one minute deflation of the angioplasty balloon, starting within one minute of reflow after
      direct stenting of the occluded coronary artery.
    

Intervention name(s): Postconditioning; standard angioplasty
Intervention type(s): Procedure; Procedure
Intervention description(s): Postconditioning during angioplasty; standard angioplasty without postconditioning
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Ischemia; Reperfusion; Myocardial infarction; Postconditioning
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of ABT-450 With Ritonavir (ABT-450/r) When Given Together With ABT-333 and Ribavirin (RBV) in Treatment-Naïve and Non-responder Subjects With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection
Condition: Chronic Hepatitis C Infection; Hepatitis C; Hepatitis C Virus
MeSH terms: Infections; Communicable Diseases; Hepatitis A; Hepatitis C; Hepatitis C, Chronic; Hepatitis; Hepatitis, Chronic
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate the antiviral activity, safety, and pharmacokinetics
      of ABT-450 with ritonavir (ABT-450/r) dosed in combination with ABT-333 (also known as
      dasabuvir) and ribavirin (RBV) in treatment-naïve and non responder participants with
      genotype 1 chronic hepatitis C virus (HCV) infection.
    

Detailed description: 
      This was a phase 2a multicenter, open-label, sequential, 3-arm, combination treatment study
      of a regimen of ABT-450/r/ABT-333, and ribavirin (RBV) in hepatitis C virus (HCV) genotype
      1-infected treatment-naïve participants and previous non-responders to pegylated interferon
      (pegIFN)/RBV treatment.
    

Intervention name(s): ABT-450; ABT-333; ribavirin; ritonavir
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): tablets; tablets; tablets; capsules
Other intervention name(s): dasabuvir; Norvir
Intervention MeSH terms: Ritonavir; Ribavirin
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
An Evaluation of Yoga Therapy for Cervical Spondylosis
Condition: Cervical Spondylosis; Neck Pain
MeSH terms: Spondylosis; Neck Pain
Study type: Interventional

Summary: 
      Cervical spondylosis is a chronic degenerative condition, commonly affecting >40-year-old
      adults worldwide. Cervical spondylosis is an important cause of neck pain and low back pain,
      and seriously affects the physical health, mental health, patients quality of life. Yoga has
      been most commonly used intervention for pain conditions. But its efficacy in cervical
      spondylosis has not yet been studied in clinical trials. The primary aim of the present study
      was to assess the efficacy of yoga chikitsa (therapy) compared with control intervention for
      neck pain caused by cervical spondylosis.
    


Intervention name(s): Yoga Therapy
Intervention type(s): Other
Intervention description(s): An hour of yoga therapy included loosening exercise (sukshma vyayama), yoga postures (asana), yoga breathing (pranayama), relaxation (shavasana) and meditation.
Each participant were given handouts to follow home practice sessions everyday for twice a day for at least 15 minutes.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Supportive Care
Bloodsafe Ghana- Iron and Nutritional Counseling Strategy Pilot Study
Condition: Iron-deficiency Anemia; Iron-deficiency
MeSH terms: Anemia, Iron-Deficiency; Iron Deficiencies
Study type: Interventional

Summary: 
      This pilot study has 2 components: 1) a cross-sectional assessment designed to estimate the
      prevalence of anaemia leading to donor deferral, the prevalence of iron deficiency (ID) and
      iron deficiency anaemia (IDA) among first-time donors, and 2) a longitudinal 2-arm parallel
      groups trial among first- time voluntary donors that compares haemoglobin levels at 4 months
      among those with ID or IDA who receive iron supplementation to those without ID or IDA who do
      not receive iron supplementation. A structured questionnaire will be used to extract
      demographic characteristics. Participants will be followed for a total of 6 months with study
      visits at 2, 4 and 6 months after the baseline assessments. Blood draws for full blood count
      (FBC), peripheral film comment, malaria rapid diagnostic tests (RDT) and ferritin assessment
      will occur at baseline and all follow-up visits. In addition, we will use a qualitative
      approach to identify barriers and facilitators of blood donation and the use of dietary and
      iron supplementation strategies to address iron deficiency and/or anaemia. This will involve
      conducting focus group discussions during the last month of the intervention and key
      informant interviews.

      Expected Outcomes The expected outcomes of the study have been grouped into two, primary and
      secondary. Primary Outcome will be haemoglobin level after 4 months. Secondary Outcomes are
      A. Change in haemoglobin levels B. Diagnosis of ID or IDA at 4 months C. Serum ferritin
      concentration after 4 months of intervention D. Acceptability of iron supplementation among
      participants and stakeholders E. Incidence of gastrointestinal adverse events F. Incidence of
      suspected malaria or bacterial infections G. Incidence of ID and IDA H. Successful return
      (non-deferred) to the blood donor pool after intervention within 6 months of enrolment I. Key
      barriers and facilitators of intervention implementation.
    


Intervention name(s): Iron Supplementation
Intervention type(s): Dietary Supplement
Intervention description(s): low dose ferrous sulphate (65mg elemental iron) supplements
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Blood donation
Effects of Automated Adjustment of FiO2 on Cerebral and Arterial Oxygenation in Preterm Infants
Condition: Preterm Infant; RDS
MeSH terms: Premature Birth
Study type: Interventional

Summary: 
      In this study the investigators test the hypothesis that automated FiO2 adjustment increases
      the time of brain tissue oxygenation within the intended reference range. Furthermore, the
      investigators studied the change in workload during automated FiO2 adjustment as compared to
      manual adjustment by the nursing staff.
    

Detailed description: 
      Recorded data on brain tissue oxygenation will be compared with reference data obtained from
      other studies. Data from experimental mode (automated FiO2 control will be compared with
      manual FiO2 control).
    

Intervention name(s): Automated FiO2 Control
Intervention type(s): Device
Intervention description(s): Infants will be ventilated with or without automated FiO2-Control in a randomized sequence.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Which Type of Transcutaneous Electrical Nerve Stimulation is More Effective in Myofascial Pain Syndrome?
Condition: Myofascial Pain Syndromes
MeSH terms: Myofascial Pain Syndromes; Fibromyalgia; Syndrome; Somatoform Disorders
Study type: Interventional

Summary: 
      The aim of this project is to compare the effects of conventional, burst and modulated TENS
      primarily on pain level, number of trigger points, pressure pain threshold, neck joint range
      of motion and disability in MAS treatment.
    

Detailed description: 
      Myofascial pain syndrome (MAS) is a regional pain syndrome characterized by trigger points
      detected by one or several muscle groups and reflected pain manifestation caused by palpation
      of these points. Transcutaneous electrical nerve stimulation (TENS) is a physical therapy
      modality that provides an analgesic effect by delivering a controlled low voltage electrical
      current to the nervous system through electrodes placed on the skin. Knowledge on how
      modulation parameters such as frequency, wave width and form alter TENS activity are limited.
    

Intervention name(s): Transcutaneous electrical nerve stimulation; Hot pack
Intervention type(s): Device; Device
Intervention description(s): All groups were administered hotpack for 20 minutes, different types of TENS therapy for 20 minutes, 5 days a week, total of 15 sessions.; All groups were administered hotpack for 20 minutes, different types of TENS therapy for 20 minutes, 5 days a week, total of 15 sessions.
Other intervention name(s): TENS
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Myofascial Pain Syndromes; Transcutaneous Electrical Nerve Stimulation
Measuring the Feasibility and the Effects of Chair Massage on Pain and Discomfort in the Cardiac Sonographer
Condition: Overuse Injury; Repetitive Strain Injury
MeSH terms: Wounds and Injuries; Cumulative Trauma Disorders
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether the effects of chair massage and/or chair
      massage with stretching may reduce musculoskeletal pain and discomfort related symptoms
      associated with the job duties of a cardiac sonographer.
    

Detailed description: 
      Staff performing echocardiography exams work in a physically demanding environment. The
      physical and psychosocial demands of the work environment place a significant amount of
      stress on the physical well being of the employee. The nature of the work involved includes
      repetitive movements and static holds while applying intense pressure. These compounded by a
      challenging ergonomic work environment, often leads to physical tension, pain, and fatigue.
      Staff and patient characteristics, in particular obesity, present greater ergonomic
      challenges. In this setting, optimal ergonomics can be difficult to achieve. Repetitive
      actions in an ergonomically challenging environment can have an accumulative effect that can
      lead to injury.

      Massage therapy has been noted to decrease levels of anxiety and fatigue which is essential
      to maintaining efficient care in a dynamic environment. Repetitive use, typically leads to
      shortened, tight muscles that fatigue over time. Once the massage therapy has released the
      connective tissue tension and restored muscle imbalances, exercise focused on core, trunk
      strength and those muscles which oppose the repetitively used muscles can further assist the
      therapeutic benefits of massage.

      The cardiac sonographer is usually sitting and reaching forward or to the side, and the
      musculoskeletal imbalances show up primarily superior to the hips. Massage Therapy research
      for alleviating musculoskeletal symptoms has been with the use of table massage whereas chair
      massage research has focused on gaining physiological benefits. Chair massage therapy impacts
      the head, back, neck shoulders, arms and hands so does impact the areas of musculoskeletal
      imbalance of the cardiac sonographer. In addition, a massage chair is easy to set up, does
      not need a great deal of space, and can be provided in semi-private area, as the participant
      remains clothed. Chair massage literature to date has focused more on physiological responses
      and albeit positive, not as much on musculoskeletal responses.
    

Intervention name(s): Massages ± Stretches
Intervention type(s): Procedure
Intervention description(s): Chair Massage
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Massage; Chair Massage; Pain; Discomfort; Stretching; Stretching Exercises; Sonographer; Cardiac Sonographer
Get in the GROOVE!
Condition: Health Behavior; Prevention Harmful Effects
Study type: Interventional

Summary: 
      Get in the GROOVE! will address health disparities impacting underserved youth. Given the
      alarming rate of overweight and obesity among high school minority youth, the project will
      focus on middle school with the primary aim of reaching middle school girls before unhealthy
      habits become firmly ingrained.

      The primary aim of the research project is to investigate the impact of two types of summer
      science enrichment programs (that focus on health and wellness) on middle school girls'
      self-efficacy, health knowledge, health behaviors, and interest in science. One program will
      present the curriculum by conventional means (GROOVE condition) while the second program will
      include the addition of a closed 3-D virtual world environment to reinforce concepts (GROOVE+
      condition).

      The following hypotheses will be tested in the randomized controlled trial:

        1. Upon completion of the summer program, the enhanced summer program GROOVE+ relative to
           the conventional summer program will result in a) increased self-efficacy for adopting
           healthy behavior change; b) increased health knowledge; c) enhanced science
           self-concept; and e) more positive behavior change (e.g., improved nutrition, increased
           physical activity).

        2. At follow-up, the enhanced summer program relative to the conventional summer program
           will result in further and/or sustained improvements in positive behavior health
           behaviors and attitudes.
    


Intervention name(s): Summer science wellness program emphasizing health education pertaining to nutrition, physical activity, and healthy lifestyle.
Intervention type(s): Other
Intervention description(s): The enhanced virtual world education (GROOVE+) will be compared to conventional approach (GROOVE). Each program is Monday-Friday, 9:30-3:30, for 3 weeks in the summer.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Comparison of New Technique Taping and Placebo Taping on Patellofemoral Pain Syndrome: A Randomised Controlled Study
Condition: Patello Femoral Syndrome
MeSH terms: Patellofemoral Pain Syndrome; Syndrome
Study type: Interventional

Summary: 
      We included in this study 42 individuals with patellofemoral pain syndrome. 39 of them were
      completed six weeks of exercise and other groups. We randomized them into three groups. One
      group is the star technique which is a new patellar taping technique. Another group is
      placebo taping and the third group is only the exercise group. Both groups performed
      exercises three times a week for six weeks. Three groups were assessed with knee and hip
      muscles strength, shortness, performance tests, pain severity in the activity, night, rest,
      and knee-buckling, and Kujala Scale before and after 4-week exercises.
    

Detailed description: 
      Based on previous studies those participants who met the following inclusion criteria were
      invited to participate in the study: i) insidious onset of anterior knee pain with a duration
      greater than 4 weeks; ii) pain provoked by at least two of the following situations:
      prolonged sitting or kneeling, squatting, running, hopping or ascending or descending stairs;
      iii) age ranged between 18-60 years.

      Participants were excluded in cases of the clinical history of patellofemoral dislocation or
      subluxation; knee osteoarthritis; injury or pain from the hip, lumbar spine, or other knee
      structures (meniscus, ligaments, bursa, synovial plica, infrapatellar fat); traumatic lesions
      of soft tissues or previous orthopedic surgery in lower limbs; having received knee
      injections of corticosteroids or hyaluronic acid; cognition or impaired communication; being
      involved in an ongoing medical-legal dispute; using Canadien or walker; can not walk
      independently and having an allergy to taping.
    

Intervention name(s): Exercise
Intervention type(s): Other
Intervention description(s): Participants of this study exercised strengthening and stretching 3 days a week for 6 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Patella Femoral Pain Syndrome; Exercise; Elastic taping; Pain; Kinesiotaping
Gait Analysis in Ponseti Clubfoot
Condition: Clubfoot
MeSH terms: Clubfoot; Talipes; Equinus Deformity; Foot Deformities
Study type: Observational

Summary: 
      Patients with clubfoot treated with the Ponseti method from a prospective database are
      evaluated using gait analysis including a foot model and a disease specific instrument score
      and compared to a group of healthy children.
    

Detailed description: 
      Patients with a minimum age of three years from a prospective, consecutive database of
      patients with clubfoot treated with the Ponseti method beginning in 2002 are considered for
      this study. Thereby patients will typically have a follow up of nearly three to eight years
      after initial clubfoot correction. Patients with unilateral or bilateral idiopathic clubfoot
      are included. Patients with clubfoot associated with syndromes or neurological diseases, with
      mild clubfoot that required fewer than three casts for initial correction, who first
      presented at an age older than three months, who were living outside of the country, and who
      were initially treated elsewhere with more than three casts are excluded. An invitation
      letter to participate in the study was sent out at the end of 2011, with a second letter
      being sent out three months after the first. After the second letter patients had a time
      frame of three more months to participate before the study was closed.

      To comprise a control group for the purpose of collecting gait analysis data of healthy
      children, employees of our hospital are asked to allow their children to participate in this
      study.

      Each patient will be physically examined, active and passive range of motion (ROM) of the
      ankle joint will be measured with a hand-held goniometer. Ability to walk on the heels and on
      tiptoes will be recorded. The disease-specific instrument questionnaire, which will be
      blinded for the treating physician will be handed out to fill in.

      Patients will undergo gait analysis, including video recordings with a Vicon motion capture
      system (Vicon, Oxford, UK) with kinetic data collected from three AMTI force plates (Advanced
      Mechanical Technology, Inc., Watertown, MA). Placement of markers will be a combination of
      Cleveland (lower extremity), PlugInGait (upper body), and Oxford Foot (movement within the
      foot) models.
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with a minimum age of three years from a prospective, consecutive database of
        patients with clubfoot treated with the Ponseti method beginning in 2002
      
Keywords: clubfoot; gait analysis; outcome questionaire; Ponseti method
Safety, Pharmacokinetic, and Pharmacodynamic Study of NKTT120 in Adult Patients With Stable Sickle Cell Disease (SCD)
Condition: Sickle Cell Disease
MeSH terms: Anemia, Sickle Cell
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine the safety, pharmacokinetics, and pharmacodynamics
      of NKTT120 in adult patients with stable sickle cell disease.
    


Intervention name(s): NKTT120
Intervention type(s): Drug
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Sickle cell disease
Clinical Outcome Study for the Triathlon Cruciate Retaining (CR) Total Knee
Condition: Total Knee Arthroplasty
Study type: Interventional

Summary: 
      An open label, post-market, non-randomised, historical controlled, multi-centre study of the
      outcomes of the Triathlon Cruciate Retaining (CR) Total Knee System.
    

Detailed description: 
      An open label, post-market, non-randomised, historical controlled, multi-centre study of the
      outcomes of the Triathlon Cruciate Retaining (CR) Total Knee System. The primary objective of
      this study will be to compare the active range of motion values for the Triathlon CR Total
      Knee System with those of the Scorpio CR Total Knee System, a historical control group. ROM
      values will be measured by use of a Goniometer according to the protocol. It is expected that
      the Triathlon CR Total Knee System group's range of motion is not 5 degrees worse or superior
      to the control group's range of motion at two-years.
    

Intervention name(s): Triathlon CR Total Knee System
Intervention type(s): Device
Intervention description(s): Primary total knee replacement
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Knee Replacement; Arthroplasty
Urinary Creatinin/Protein Ratio in Preterms
Condition: Preterm Infant; Renal Failure
MeSH terms: Premature Birth
Study type: Observational

Summary: 
      From the first days of life, the newborn presents a "physiological" proteinuria explained by
      the coexistence of a glomerular and tubular immaturity, all the more marked as the
      gestational age (GA) is weak. In the child term, proteinuria decreases the first month and
      its persistence is the marker of kidney damage. The persistence of proteinuria in preterm
      infants is also considered a marker of renal impairment; however, neither the "physiological"
      values nor the pattern of urinary excretion of proteins in the first month of life are known.

      The proteinuria / creatininuria ratio is a validated indicator of proteinuria, as it is
      correlated with 24-hour urine proteinuria.
    


Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Premature gestational age at birth superior or equal to 32 week of amenorrhea