bioihbjkbjnl/mcl2 huggingface dataset:
Migraine and Endothelial Dysfunction
Condition: Migraine With Aura
MeSH terms: Migraine Disorders; Migraine with Aura
Study type: Observational

Summary: 
      Recently, there is evidence that endothelial activation and dysfunction are associated with
      migraine, especially in female migraineurs with aura. Our objectives were to determine
      whether novel endothelial function markers are altered in female migraineurs with aura
      compared to age-matched controls.
    

Detailed description: 
      Our objectives were to determine whether novel endothelial function methods and novel markers
      of endothelial activation are associated with migraine in female migraineurs with aura.

      Migraine is an independent risk factor for stroke, especially in young women with aura
      symptoms. Endothelial dysfunction is a risk factor for cardiovascular diseases. Recent
      studies suggest that there is a link between migraine with aura and endothelial activation,
      dysfunction and impaired vascular reactivity.

      In this case-control study the investigators examine several novel biomarkers of endothelial
      function such as endothelial progenitor cells and endothelial microparticles as well as novel
      methods such as reactive hyperemic peripheral arterial tonometry in female migraineurs with
      aura and age-matched controls.
    

Observational model: Case-Control
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        female migraineurs from outpatient clinic
      
Keywords: Migraine with aura
Topical Agent for Treatment of Red Skin
Condition: Rosacea; Bilaterally Symmetric Red Skin on Cheeks
MeSH terms: Rosacea
Study type: Interventional
Phase: Phase 1

Summary: 
      SR-01 may reduce facial redness. it is a topically applied product. The agent will be applied
      to local skin areas of subjects with red facial skin to assess affect, and then applied to
      the whole face to assess efficacy and safety
    


Intervention name(s): Topical SR-01
Intervention type(s): Drug
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Safety Trial of DAS181 (Fludase®) in Adult Subjects With Well-Controlled Asthma or Bronchiectasis
Condition: Asthma; Bronchiectasis
MeSH terms: Asthma; Bronchiectasis
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary objective is to evaluate whether DAS181 is safe in subjects with well-controlled
      asthma or bronchiectasis.
    

Detailed description: 
      This study will assess the safety of a new study drug called DAS181 (Fludase®). This study is
      being done with NexBio, Inc., the company that makes DAS181 (Fludase®). DAS181 is not
      approved by the Food and Drug Administration (FDA); however the FDA has given permission to
      use DAS181 in human studies. To date, DAS181 has been given to about 81 healthy people and
      has been well tolerated with no reported serious adverse reactions. This is the first
      experimental study to test if it is safe to use this drug in people with well-controlled
      asthma or bronchiectasis. DAS181 is not being given to treat asthma or bronchiectasis, but to
      learn if it is safe to use in people with well-controlled asthma or bronchiectasis. DAS181 is
      being developed as a medication to prevent and treat infections due to common respiratory
      viruses like influenza (including the pandemic H1N1 strain), parainfluenza, and other
      viruses. New drugs to treat respiratory viruses are needed because some currently available
      drugs are not effective against some types or strains of viruses. Drugs that are effective
      against respiratory viruses are especially important for people with asthma or bronchiectasis
      because these lung conditions increase the risk of serious complications due to respiratory
      virus infections. Making sure the new drug is safe in people with asthma or bronchiectasis is
      important because people with these lung conditions may have different side effects from a
      drug than people who don't have asthma or bronchiectasis. We plan to enroll 24 volunteers
      into the study: 12 persons with well-controlled asthma and 12 persons with bronchiectasis.
    

Intervention name(s): DAS181 dry powder, formulation F02; Respitose ML006 (DMV-Fonterra)
Intervention type(s): Drug; Drug
Intervention description(s): 10 mg delivered dose DAS181 in clear HPMC #3 Capsules; Lactose monohydrate
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Asthma; Bronchiectasis
Effect of the Pelvic Loin Musculature Training on the Dynamic Hip Stabilization
Condition: Exercise Addiction
MeSH terms: Behavior, Addictive
Study type: Interventional

Summary: 
      Introduction: The stability of the pelvis is of great importance in body balance as a whole,
      can be improved by training the pelvic muscles fillet (MLP), which is characterized by low
      intensity isometric synchronous and the deep muscles of the trunk. This study aims to
      determine the effect of a stability program target, with the training of the MLP region on
      pelvic stability.
    

Detailed description: 
      This study aims to determine the effect of a stability program target, with the training of
      the MLP region on pelvic stability. Materials and Methods: We recruited 20 volunteers of both
      sexes were randomly divided into control group (CG) and training group (TG). The evaluations
      were performed before and after training the MLP. The training was held four isometrics
      series with a time of 30 seconds with 30 seconds rest in between reps during 10 sessions
      distributed twice weekly.
    

Intervention name(s): Core Training Group
Intervention type(s): Procedure
Intervention description(s): Performs oriented exercise segmental stabilization lumbar-pelvic.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Diagnostic
Keywords: physiotherapeutic techniques; pelvis; Muscle strength
The Incidence of Pelvic Hematoma Following Hysterectomy
Condition: Hematoma
MeSH terms: Hematoma
Study type: Observational

Summary: 
      Hysterectomy is one of the common operations in gynecology. With population aging in modern
      society, the incidence of these surgeries is expected to increase even more. One of the major
      complications of pelvic surgery is symptomatic pelvic hematoma, which can present with pain,
      fever, and foul smelling discharge. The incidence of pelvic hematoma is 40%, and varies
      according to the type of hysterectomy and the diagnostic procedure. Those hematoma increase
      the risk for infection. Diagnosis usually is not a clinical one unless symptoms occur, and
      then the diagnosis is made by CT or ultrasound. Number of interventions are mentioned in the
      literature to try and decrease post operative complications and infections, none have
      suggested effective enough. This is a prospective study which objective is to characterize
      the incidence of pelvic hematoma following hysterectomy using ultrasound. The investigators
      will also try to identify preoperative, intraoperative and postoperative risk factors for
      infection of this hematomas. This identification might decrease the incidence of
      postoperative hematoma and infection.
    

Detailed description: 
      aging in modern society, the incidence of these surgeries is expected to increase even more.
      One of the major complications of pelvic surgery is symptomatic pelvic hematoma, which can
      present with pain, fever, and foul smelling discharge. The incidence of pelvic hematoma is
      40%, and varies according to the type of hysterectomy and the diagnostic procedure. Those
      hematoma increase the risk for infection. Diagnosis usually is not a clinical one unless
      symptoms occur, and then the diagnosis is made by CT or ultrasound. Number of interventions
      are mentioned in the literature to try and decrease post operative complications and
      infections, none have suggested effective enough. This is a prospective study which objective
      is to characterize the incidence of pelvic hematoma following hysterectomy using ultrasound.
      The investigators will also try to identify preoperative, intraoperative and postoperative
      risk factors for infection of this hematomas. This identification might decrease the
      incidence of postoperative hematoma and infection.
    

Intervention name(s): Ultrasound examination
Intervention type(s): Other
Intervention description(s): Ultrasound examination following hysterectomy
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Women following hysterectomy
RETHINC: REdefining THerapy In Early COPD for the Pulmonary Trials Cooperative
Condition: COPD (Chronic Obstructive Pulmonary Disease)
MeSH terms: Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Study type: Interventional
Phase: Phase 3

Summary: 
      The study hypothesis is that symptomatic current and former smokers with spirometric values
      within the normal range (post-bronchodilator FEV1/FVC≥0.70 and post-BD FVC ≥ 70% predicted
      will still derive symptomatic benefit from long-acting bronchodilator therapy even though
      they are excluded from current GOLD guideline recommendations.
    

Detailed description: 
      RETHINC is a 12-week multicenter, randomized, double-blind, placebo-controlled,
      parallel-group study to assess the efficacy and safety of indacaterol/glycopyrrolate
      27.5/15.6 mcg inhaled twice daily in symptomatic current and former smokers with respiratory
      symptoms despite preserved spirometry as defined by CAT ≥ 10 and post-bronchodilator FEV1/FVC
      ratio ≥0.70, respectively.
    

Intervention name(s): Indacaterol/Glycopyrrolate; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 27.5/15.6 mcg active indacaterol/glycopyrrolate; 27.5/15.6 mcg placebo
Intervention MeSH terms: Glycopyrrolate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: COPD; Chronic Obstructive Pulmonary Disease; Pulmonary Function Tests; Current Smoker; Former Smoker; Chronic Obstructive Airway Disease; Respiratory Symptoms
Effect of SCH 497079 on Metabolic Parameters and Influence of Race/Ethnic Origin on Therapeutic Response (Study P05338)(COMPLETED)
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the effect of SCH 497079 on metabolic parameters and
      to determine the influence of race/ethnic origin on therapeutic response.
    

Detailed description: 
      This study includes two parts, each part includes three consecutive 28-day treatment periods.
      Part 1 (to be conducted in the United States): each participant will receive the following
      treatments for 28 days in each of three treatment periods in an order determined by a random
      code: SCH 497079, or matching placebo, or metformin.

      Part 2 (to be conducted in India): this part of the study will be conducted after completion
      of Part 1 and an analysis indicates a clinically significant decrease in blood glucose in
      participants with type 2 diabetes mellitus (T2DM) compared to placebo. The same procedures
      conducted in Part 1 will be conducted in Part 2.
    

Intervention name(s): SCH 497079; Placebo; Metformin
Intervention type(s): Drug; Drug; Drug
Intervention description(s): SCH 497079 100 mg capsule, administered orally, once daily for 4 weeks; Placebo capsules matching SCH 497079, administered orally, once daily for 4 weeks; Metformin extended release 750 mg, 2 tablets administered orally, once daily for 4 weeks (1500 mg total daily dose)
Intervention MeSH terms: Metformin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Metabolic Syndrome Risk Factor in IGT: STOP-NIDDM Trial
Condition: Metabolic Syndrome
MeSH terms: Metabolic Syndrome; Syndrome
Study type: Interventional
Phase: Phase 3

Summary: 
      The aim of the study was to analyse the independent and joint effects of the components of
      the metabolic syndrome (MetS) on the incidence of diabetes in people with impaired glucose
      tolerance (IGT) and to assess the effect of acarbose by MetS status.

      Double-blind placebo controlled trial, 1,368 patients, follow-up time 3.3 years. MetS by ATP
      III definition with fasting plasma glucose of ≥ 6.1 mmol/l as limit for impaired fasting
      glucose (IFG).
    


Intervention name(s): acarbose; placebo
Intervention type(s): Drug; Drug
Intervention MeSH terms: Acarbose
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Keywords: prevention,; type 2 diabetes,; metabolic syndrome,; acarbose treatment
Metabolic Effects of Subchronic Dopamine D2 Receptor Blockade by Antipsychotic Drugs in Healthy Humans
Condition: Insulin Resistance; Dyslipidemia
MeSH terms: Insulin Resistance; Dyslipidemias
Study type: Interventional

Summary: 
      We hypothesized that short-term treatment with AP drugs induces insulin resistance through a
      mechanistic route that is independent of weight gain and that atypical drugs exert stronger
      effects than typical compounds in this respect. We therefore treated healthy non-obese men
      with olanzapine (atypical AP) or haloperidol (typical AP) for 8 days, and studied the impact
      of these interventions on glucose and lipid metabolism by hyperinsulinemic euglycemic clamp,
      isotope dilution technology and indirect calorimetry.
    


Intervention name(s): olanzapine; Haloperidol
Intervention type(s): Drug; Drug
Intervention description(s): olanzapine 10 mg/day for 8 days; haloperidol 3 mg/day for 8 days
Other intervention name(s): Zyprexa
Intervention MeSH terms: Haloperidol; Olanzapine; Haloperidol decanoate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Keywords: Antipsychotics; Olanzapine; Haloperidol; Insulin resistance; Dyslipidemia
The Impact of Maternal Obesity on Pregnancy Outcomes in El-Minia Locality
Condition: Obesity During Pregnancy in Clinical Practice
MeSH terms: Obesity, Maternal; Obesity
Study type: Observational

Summary: 
      A study will carried out over a period of one year , all obese pregnant women as diagnosed
      with BMI at the time of 1st ANC visit and before labor ,observation of events during both
      intra-partum &postpartum periods it will be recorded.outcome will compared with normal other
      pregnant women
    

Detailed description: 
      It is known that obesity during pregnancy has drawbacks for both maternal and foetal outcome
      The aim of this study is to evaluate and measure the proportion of the adverse pregnancy
      outcomes attributable to maternal obesity and so reaching to recommendations in order to
      improve the outcomes and wellbeing of these women and their children.patient will be divided
      into two groups control group with normal BMI and study group and both compared as regard
      foetal and maternal outcome The assessed fetal variables will be: fetal birthweight &
      incubators admission. Data will be retrieved from patients before labor and from investigator
      observation both intrapartum and postpartum.
    

Intervention name(s): The impact of maternal obesity on pregnancy outcomes
Intervention type(s): Other
Intervention description(s): observation of maternal obesity effect in foetal and maternal outcome
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        pregnant women with BMI more than 24 per meter square body surface area
      
Keywords: obesity , pregnancy , maternal and fetal outcome
Identification of New Serum Markers for Detection of Abuse With Erythropoietin
Condition: Substance Abuse Problem
MeSH terms: Substance-Related Disorders
Study type: Interventional

Summary: 
      Epo increases red blood cell production and hence the amount of oxygen that can be
      transported around the body. It is shown that prolonged use of synthetic Epo (rHuEpo) leads
      to an increase in the period of time a given physical work can be performed, therefore it
      will continue to be abused by athletes, especially in endurance sports.

      The existing method for measuring the abuse of rHuEpo approved by the World Anti-Doping
      Agency (WADA) is based on differences in the sugar groups bound to rHuEpo and Epo produced in
      the body, respectively.

      Proteomics is a method by which one can look at all the proteins in blood at the same time.
      Even proteins that have changed very little can be distinguished. The main objective of this
      project is to investigate the effect of prolonged treatment with rHuEpo on changes in blood
      proteins in healthy young men.
    


Intervention name(s): recombinant human erythropoietin; Training; Placebo
Intervention type(s): Drug; Behavioral; Other
Intervention description(s): rHuEpo (5000 IU)is administered using a small syringe under the skin every other day for the first 2 weeks, on 3 consecutive days during week 3, and once a week from week 4-10.; For ten weeks participants will receive supervised endurance training on a bike three times a week. Physical effect will be examined with VO2-max tests before during and after the training period.; placebo (saline) is administered using a small syringe under the skin every other day for the first 2 weeks, on 3 consecutive days during week 3, and once a week from week 4-12.
Intervention MeSH terms: Epoetin Alfa
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: EPO; Proteomics; Carbohydrate metabolism; Fat metabolism; Protein metabolism
Efficacy of Desensitizers in Reducing Post-operative Sensitivity Following Composite Restorations
Condition: Sensitivity
MeSH terms: Hypersensitivity
Study type: Interventional

Summary: 
      Composite is one of the common aesthetic restorations used in the dentistry. With the
      advancements in the biomaterials the application of the composites has broadened. However due
      to various factors the composites are associated with dental sensitivity. Hence in our study
      we evaluate and compare the effectiveness of three desensitizing agents in reducing the
      post-treatment sensitivity for class I composite restoration.
    

Detailed description: 
      A double-blind, randomized, controlled clinical trial was conducted in which 80 subjects
      requiring class I cavity were randomly assigned to 4 groups of 20 patients each: Group C
      (Control group), Group GL (Gluma group), Group SF (Shield Force Plus group), and Group TC
      (Telio CS group). The class 1 cavity was prepared and after etching, the desensitizers were
      applied (except in the control group) and later composite restoration was done. The
      postoperative pain/sensitivity level was recorded according to the Visual Analogue Scale
      (VAS) on intake of cold drinks; intake of hot drinks; and intake of sugar for different
      periods of time.
    

Intervention name(s): Gluma desensitiser; Sheildforce Plus desensitiser; Telio CS desensitiser
Intervention type(s): Combination Product; Combination Product; Combination Product
Intervention description(s): Gluma desensitiser was used before restoration.; Sheildforce Plus desensitiser was used before restoration.; Telio CS desensitiser was used before restoration.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Keywords: Gluma; Sheildforce Plus; Telio CS; Desensitisers
Effects of Exercise Training in Patients With Atrial Fibrillation and Sleep Apnea: A Pilot Study
Condition: Sleep Deprivation
MeSH terms: Sleep Deprivation; Atrial Fibrillation
Study type: Interventional

Summary: 
      Background: There are still many gaps in research concerning the effect of different physical
      training modalities on sleep deprivation in the population with different types of sleep
      apnea. Aims: The purpose of this study was to examine the effect of moderate-intensity
      interval training (MITT) on patients with different types of sleep apnea.
    

Detailed description: 
      Methods: 15 Participants aged 45-65 years were randomized into two groups: obstructive sleep
      apnea group (OSA), and central sleep apnea group (CSA). The training lasted ten consecutive
      weeks with 30 uninterrupted sessions. The actigraph together with the Pittsburg sleep quality
      index (PSQI) was used in sleep quality assessment. The actigraph (Actiwatch Minimitter
      Company, Incorporated (INC) - Sunriver, OR, USA) was placed on the non-dominant wrist and
      activities were monitored continuously while being recorded at one-minute intervals. The
      participants kept the device for a period of 96 hours, filled PSQI, and did 6MWT before the
      first and last training sessions.
    

Intervention name(s): Moderate intensity interval training (MITT)
Intervention type(s): Behavioral
Intervention description(s): interval exercises (intervention) on bicycle for patients with AF and OSA or AF with CSA for 10 weeks, 3 times/week for duration of 30-45 min/ session.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Care Provider)
Primary purpose: Treatment
Silver Diamine Fluoride(SDF) Versus SDF Combined With Sodium Fluoride Varnish in the Arrest of Early Childhood Caries
Condition: Early Childhood Caries
Study type: Interventional
Phase: Phase 3

Summary: 
      Early childhood caries (ECC) is the most common chronic childhood disease worldwide. Early
      restorative intervention may treat the disease but this is often difficult especially with
      uncooperative children so it may be left untreated. Remineralization of affected dentin using
      silver diamine fluoride (SDF) can arrest these lesions.

      This trial aims to compare the effectiveness of 38% SDF solution versus 38% SDF solution with
      5% sodium fluoride (NaF) varnish after six months in arresting ECC lesions.
    


Intervention name(s): SDF; NaF
Intervention type(s): Device; Device
Intervention description(s): Silver Diamine Fluoride 38% (Applied bianually); Sodium Fluoride Varnish (5%) (Applied at baseline and after 3 months)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: ECC; SDF 38%; NaF 5%; preschoolers