bioihbjkbjnl/mcl2 huggingface dataset:
Analysis of Risk Factors of Postoperative Pulmonary Infection in Patients With Esophageal Cancer
Condition: Esophageal Neoplasms; Pneumonia
MeSH terms: Esophageal Neoplasms
Study type: Observational

Summary: 
      The goal of this observational study is to learn about in describe participant population.
      The main questions it aims to answer are:

        -  What are the risk factors of postoperative pulmonary infection in patients with
           esophageal cancer？

        -  Whether we could establish a clinical prediction model to provide basis for early
           clinical intervention or not? Participants will describe the main tasks participants
           will be asked to do, treatments they'll be given and use bullets if it is more than 2
           items. If there is a comparison group: Researchers will compare insert groups to see if
           insert effects.
    

Detailed description: 
      Data were collected from the electronic medical records of Xijing Hospital. Each record is
      entered by two team members working simultaneously to ensure data accuracy.
    

Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        From January 2016 to December 2021, patients with esophageal cancer were hospitalized for
        surgery in the Department of Gastroenterology, Xijing Hospital.
Effect of Tai Chi as Treatment for IBS-C
Condition: Irritable Bowel Syndrome With Constipation
MeSH terms: Irritable Bowel Syndrome; Constipation
Study type: Interventional

Summary: 
      The purpose of the study is to evaluate the efficacy of Tai Chi practice in reducing symptoms
      of Irritable Bowel Syndrome with Constipation (IBS-C).
    

Detailed description: 
      This is a single-center pilot study investigating the efficacy of Tai Chi practice in
      reducing symptoms of IBS. The investigators hope that subjects practicing Tai Chi will have
      reduced symptoms of IBS-C as measured through overall global symptom relief as well as the
      IBS-SSS, IBS-QOL, VSI, HADS, Visual Analogue Pain Scale, and changes in bloating, abdominal
      pain, abdominal distention, and constipation severity. The study will also use daily entries
      made through the GeoPain app to record trends in pain intensity.
    

Intervention name(s): Tai Chi
Intervention type(s): Behavioral
Intervention description(s): Tai Chi Chuan (taijiquan) or Tai Chi is a mind-body practice borne of Chinese philosophy and martial arts which has been practiced for centuries to promote deep relaxation, strengthened health, and to prevent injuries and illness.
Intervention model: Single Group Assignment
Intervention model description: This is a single-center pilot study. All patients enrolled in the study will participate in the Tai Chi treatment.
Masking: None (Open Label)
Primary purpose: Treatment
Can we Antagonize Mivacurium With Neostigmine ?
Condition: Mivacurium; Neostigmine; Residual Paralysis
MeSH terms: Paralysis
Study type: Interventional

Summary: 
      The antagonism of neuromuscular blocking agents (NMBA) (or curares), as well as the
      antagonism of other drugs used in anesthesia, is a major challenge for the speciality.

      Residual paralysis is indeed a risk factor for post-operative morbidity and mortality and
      antagonization of curares at the end of the procedure is associated with a reduction in
      mortality .

      Its use should be as large as possible and its contraindications are extremely rare.

      The antagonism of the NMBA reduces the duration of the neuromuscular block and the
      complications that are associated .

      In this study, the investigators use mivacurium (or Mivacron) as non-depolarizing curare and
      neostigmine as an antagonist.

      Neostigmine reduces the duration of the neuromuscular block induced by mivacurium, By
      reducing the breakdown of acetylcholine, neostigmine induces an increase in acetylcholine in
      the synaptic cleft which competes for the same binding site as nondepolarizing neuromuscular
      blocking agents, and reverses the neuromuscular blockade.

      But the use of neostigmine in current practice is not very widespread in this clinical
      situation.

      The reduction in the duration of the block is significant in comparison with a spontaneous
      recovery .

      Moreover, spontaneous recovery is not always complete and sometimes very long.

      Nevertheless, its action is effective and this study could support this use but also specify
      the duration and the quality of the return to normal of the neuromuscular transmission.
    


Intervention name(s): Neostigmine (40 mcg / kg) at different time of neuromuscular block's recovery; Spontaneous recovery
Intervention type(s): Drug; Other
Intervention description(s): just measuring the Train Of Four at 3 6 9 12 and 15 minutes and measure the Train Of Four Ratio
Intervention MeSH terms: Neostigmine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: mivacurium; neostigmine; antagonism
A Study on Whether Patients Prefer the Spiriva® Respimat® or the Spiriva® Handihaler® for Treating Their Chronic Obstructive Pulmonary Disease (COPD)
Condition: Pulmonary Disease, Chronic Obstructive
MeSH terms: Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Study type: Interventional
Phase: Phase 4

Summary: 
      The objective of this study is to investigate the patient acceptability/preference of
      Respimat® compared with Handihaler® in patients with moderate to very severe chronic
      obstructive pulmonary disease (COPD) to demonstrate the superiority of Respimat®.
    


Intervention name(s): Tiotropium Respimat® (T1); Tiotropium Handihaler® (T2)
Intervention type(s): Drug; Drug
Intervention description(s): inhalation solution; Inhalation Powder
Intervention MeSH terms: Tiotropium Bromide
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Study to Assess the Food Effect and the Relative Bioavailability of the Cabotegravir (CAB) Pediatric Dispersible Tablet (DT) Formulation
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will assess the relative bioavailability of the CAB DT formulation relative to
      that of the CAB IR formulation and to assess the effect of food on the CAB DT formulation.
    


Intervention name(s): Cabotegravir IR Formulation (reference); Cabotegravir DT Formulation (test 1); Cabotegravir DT Formulation (test 2)
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Cabotegravir IR Formulation (reference) will be administered.; Cabotegravir DT Formulation (test 1) will be administered.; Cabotegravir DT Formulation (test 2) will be administered.
Intervention MeSH terms: Cabotegravir
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Bioavailability; Cabotegravir; Dispersible tablet; Food effect; Human immunodeficiency virus; Immediate release tablet
Effect of Rotablator on Balloon Resistant Calcified Coronary Lesion
Condition: Coronary Artery Disease
MeSH terms: Coronary Artery Disease
Study type: Interventional

Summary: 
      The optimal treatment of calcified coronary lesion remained to be elucidated. A Prospective,
      randomized controlled trial was perform to explore the immediate effect and long-term outcome
      of rotational atherectomy in patients with balloon resistant coronary lesion.
    

Detailed description: 
      The inclusion criteria included patients presenting drug-resistant angina pectoris who
      underwent balloon resistant angioplasty.

      The exclusion criteria included:

        1. Acute myocardial infarction within the 28 days;

        2. Intolerance to aspirin, clopidogrel, contrast media, or statins;

        3. Angiographic visible thrombus, or dissection;

        4. Left ventricular ejection fraction (LVEF)<35%;

        5. Any type of cancer

        6. Hemorrhagic stroke
    

Intervention name(s): Rotablator; conventional angioplasty; stenting; Cutting balloon; Aspirin; Clopidogrel; Paclitaxel-eluting stent; zotarolimus-eluting stent; Everolimus-eluting stent; Sirolimus-eluting stent
Intervention type(s): Device; Procedure; Procedure; Device; Drug; Drug; Device; Device; Device; Device
Intervention description(s): Rotablator, Boston Scientific, Maple Grove, MN, USA. Rotablator will be used in the Rotablator arm.; Conventional angioplasty was used in both arms.; Stenting was implanted in both arms.; Flextome cutting balloon(Boston Scientific, Natick, MA, USA) was used in both arms.; Aspirin will be administrated in participants in both arms.; Clopidogrel will be administrated to participants in both arms.; Paclitaxel-eluting stent will be used in both arms.; Zotarolimus-eluting stent will be implanted in participants in both arms.; Everolimus-eluting stent will be used in both arms.; Sirolimus-eluting stent will be used in both arms.
Other intervention name(s): Rotational atherectomy; High-speed rotational atherectomy; percutaneous transluminal coronary angioplasty; Implantation of coronary stent; Flextome Cutting balloon; Bayaspirin, 100mg, tablet, oral, Germany; Plavix, Clopidogrel Bisulfate, 100mg, tablet, oral; Taxus; Resolute, Medtronic CardioVascular; Xience V; Firebird, Shanghai, China
Intervention MeSH terms: Aspirin; Sirolimus; Paclitaxel; Everolimus; Clopidogrel
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Impact of Diazepam 1% Oral Gel Efficacy in Burning Mouth Syndrome
Condition: Burning Mouth Syndrome
MeSH terms: Burning Mouth Syndrome; Syndrome; Burns
Study type: Interventional

Summary: 
      Burning mouth syndrome (BMS) is a syndrome characterized by burning and persistent oral pain,
      ranging from mild to intense, in the absence of organic disorders of the oral cavity and with
      a major impact on the quality of life of the sufferer. Although several etiological theories
      have been proposed to explain BMS, none has been universally accepted to date, and its origin
      remains unclear. Currently, several scientific evidences would suggest that underlying BMS
      would be alterations in certain neuropathic mechanisms.

      The purpose of the study is to evaluate the efficacy of Diazepam 1% oral gel in the treatment
      of burning mouth syndrome.
    

Detailed description: 
      A double-blind placebo-controlled trial is conducted in order to evaluate the efficacy of
      Diazepam 1% oral gel and determine the statistical significance of the outcome variables. 40
      patients with BMS, in two groups:

        -  case group with Diazepam 1% oral gel (Galenic formulation)

        -  control group with placebo in oral gel formulation

      Follow-up of 2 months
    

Intervention name(s): Diazepam 1% oral gel; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Diazepam 1% used with topic oral gel on tongue and palate twice daily.; Placebo oral gel used on tongue and palate twice daily.
Intervention MeSH terms: Diazepam
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The main objective of this study was to evaluate the efficacy of Diazepam 1% oral gel over placebo in the management of BMS
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Neurodevelopment in Infants With Complex Congenital Heart Defects
Condition: Complex Congenital Heart Defect
MeSH terms: Heart Defects, Congenital
Study type: Observational

Summary: 
      The primary goal of this study is to systematically describe early neurodevelopment using a
      complementary set of observational and neurophysiological measures that may predict cognitive
      and motor delays earlier than currently possible for infants with Complex Congenital Heart
      Disease (CCHD).
    

Detailed description: 
      The investigators' long-term goals are to develop a method of identifying infants likely to
      have adverse neurodevelopmental outcomes following neonatal treatment for CCHD and to develop
      and test interventions that can be applied early in infancy. The necessary first step is to
      systematically describe early neurodevelopment using a complementary set of observational and
      neurophysiological measures that may predict cognitive and motor delays earlier than
      currently possible for infants with CCHD. Each measure provides unique information about
      development and will include (1) neuroimaging for brain maturity and brain injury, (2) hair
      and fingernails for cortisol and saliva for immune system function, (3) heart rate
      variability (HRV) for autonomic nervous system function (ANS), (4) Bayley Scales of Infant
      Development (BSID-III) for cognitive and motor function, (5) a naturalistic play session
      incorporating kicking, general movement analysis, or the Test of Infant Motor Performance
      (TIMP) for motor development, and (6) the mobile paradigm for learning, memory, and
      task-specific coordination. The investigators will look at types of relationships among these
      measures within each time point for description of development and across each time point for
      prediction of development. The investigators' core hypotheses are that infants with CCHD will
      have measurable deficits in cognitive and motor development birth to ~ 6 months of age when
      compared with a healthy control group and that a typology developed from neurodevelopmental
      measures will reliably predict cognitive and motor delay in the first six months of life in
      infants with CCHD.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Participants are infants born with a complex congenital heart defect.Cardiac defects
        include, but are not be limited to: atrioventricular canal defect, double outlet right
        ventricle, hypoplastic left heart syndrome, interrupted aortic arch, pulmonary atresia,
        tetralogy of Fallot, and transposition of the great arteries.All participants are recruited
        from Nationwide Children's Hospital in Columbus, OH. Healthy infants will also be enrolled
        as a comparison group.
      
Keywords: Complex Congenital Heart Defect; Infants
Venlafaxine Versus Lamotrigine in the Treatment of Bipolar I/II Depression
Condition: Bipolar Disorder
MeSH terms: Depression; Bipolar Disorder
Study type: Interventional
Phase: Phase 4

Summary: 
      The primary objective of this study is to assess the efficacy of venlafaxine XR and
      lamotrigine when each is added to mood stabilizer therapy in patients with acute depressive
      episodes of bipolar I or Bipolar II disorder. Efficacy of therapy will be evaluated using
      improvements in clinical symptomatology after 8 weeks of treatment as measured by reductions
      on the Hamilton Depression Rating Scale (HDRS-29) total score >50% from baseline. We also
      would like to assess the efficacy of venlafaxine XR and lamotrigine when each is added to
      mood stabilizer therapy in improving clinical symptomatology after 8 weeks of therapy as well
      as to evaluate the side effect profile, safety and tolerability of venlafaxine XR and
      lamotrigine.
    

Detailed description: 
      The primary objective of this study is to assess the efficacy of venlafaxine XR and
      lamotrigine when each is added to mood stabilizer therapy in patients with acute depressive
      episodes of bipolar I or Bipolar II disorder. Efficacy of therapy will be evaluated using
      improvements in clinical symptomatology after 8 weeks of treatment as measured by reductions
      on the Hamilton Depression Rating Scale (HDRS-29) total score >50% from baseline. We also
      would like to assess the efficacy of venlafaxine XR and lamotrigine when each is added to
      mood stabilizer therapy in improving clinical symptomatology after 8 weeks of therapy as well
      as to evaluate the side effect profile, safety and tolerability of venlafaxine XR and
      lamotrigine.
    

Intervention name(s): Venlafaxine and Lamotrigine
Intervention type(s): Drug
Intervention MeSH terms: Lamotrigine; Venlafaxine Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Bipolar Disorder, Depression, Anticonvulsants, Antidepressants
Echocardiographic Assessment of Volume Variation Secondary to Preoperative Fasting
Condition: Hypovolemia
MeSH terms: Hypovolemia
Study type: Observational

Summary: 
      The primary objective of this study is to demonstrate that preoperative fasting does not
      increase the rate of lowered blood volume (defined by a variation of 15% ΔITV during a leg
      lift) in patients undergoing surgery.
    


Intervention name(s): echocardiography
Intervention type(s): Procedure
Intervention description(s): Echocardiography is performed for all patients
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients recruited during anesthesia consultations carried out before programmed
        gynecological or visceral surgeries.
      
Keywords: preoperative fasting
Fibromyalgia Outcome Research Trial Evaluating Synergistic Suppression of HSV-1
Condition: Fibromyalgia
MeSH terms: Fibromyalgia; Myofascial Pain Syndromes
Study type: Interventional
Phase: Phase 2

Summary: 
      Randomized, double-blind, placebo-controlled, 16-week study designed to explore the safety
      and efficacy of IMC-1 for the treatment of patients with fibromyalgia.
    


Intervention name(s): IMC-1; Placebo BID Tablet
Intervention type(s): Drug; Drug
Intervention description(s): Patients will take 1 tablet twice daily, each morning and evening, of randomly assigned study drug orally starting on Day 1 through study duration.; Patients will take 1 tablet twice daily, each morning and evening, of randomly assigned study drug orally starting on Day 1 through study duration.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Pain
Friends for Life Circles for Option B Plus
Condition: Human Immunodeficiency Virus
MeSH terms: Acquired Immunodeficiency Syndrome; HIV Infections
Study type: Interventional

Summary: 
      The main goal of the study is to support HIV-infected pregnant women initiated on PMTCT
      Option B+ during antenatal to adhere to lifelong ART and postpartum care visits through an
      enhanced group peer support intervention called "friends for life circles".
    

Detailed description: 
      The overall goal of this implementation research is to improve retention in care and
      adherence to ART to 2 years postpartum among HIV infected women in urban and rural Uganda
      choosing PMTCT Option B+. Formative research will first be conducted to assess knowledge and
      attitudes regarding Option B+ and lifelong ART among PMTCT clients, community members and
      health workers. The formative research will inform the design of the group peer support
      intervention. Interventional research will then be conducted randomizing 540 women to either
      enhanced group peer support with income generating activities called the Friends for Life
      Circle (FLC) or MOH standard of care counselling with follow-up to 2 years postpartum.
      Primary outcomes will include retention in health care, ARV adherence and viral suppression
      at 6 weeks and 24 months postpartum. Secondary outcomes will include participants' health and
      economic outcomes.
    

Intervention name(s): Friends for Life Circles (FLCs).
Intervention type(s): Other
Intervention description(s): The intervention 'Friends for Life Circles" (FLCs) will build dynamic peer group support in the community aimed at supporting maternal adherence to appointment keeping and taking lifetime antiretroviral drugs
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Option B plus; HIV infected women
Vasodilator-induced Hypovolemia in Living Liver Donors
Condition: CVP and SVV During Living Donor Hepatectomy; Surgical Field Grade (Condition of Surgical Field; Bleeding, Tension of the IVC)
MeSH terms: Hypovolemia
Study type: Interventional

Summary: 
      Induced hypovolemia is known to improve surgical field during living donor hepatectomy. This
      procedure is conventionally guided by monitoring the central venous pressure (CVP). Stroke
      volume variation (SVV) is a novel method to substitute with CVP to monitor cardiac preload.
      The investigators try to evaluate the relationship between CVP and SVV during CVP-guided
      vasodilator induced hypovolemia (validation study). Then, feasibility of vasodilator induced
      hypovolemia using the SVV calculated from the validation study will be tested (feasibility
      study).
    

Detailed description: 
      This is a 2-phases study.

      first phase validation study : Evaluation of the relationship between CVP and SVV during
      CVP-guided vasodilator induced hypovolemia

      second phase feasibility study

      : Comparison of the surgical field grade between validation study group(CVP guided group) and
      feasibility study group(SVV guided group)
    

Intervention name(s): vasodilator induced hypovolemia
Intervention type(s): Procedure
Other intervention name(s): Milrinone induced hypovolemia
Intervention MeSH terms: Milrinone; Vasodilator Agents
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: liver donor; hepatectomy; vasodilator; central venous pressure; stroke volume variation