bioihbjkbjnl/mcl2 huggingface dataset:
The Relationship of Platelet Micro-RNA Expression and Platelet Reactivity in Patients Under Clopidogrel or Ticagrelor Treatment
Condition: PRU; miRNA
Study type: Interventional

Summary: 
      For acute coronary syndrome patients undergoing cardiac catheterization after stenting, we
      will give dual antiplatelet drugs (dual antiplatelet agents) therapy, the choice of the basis
      of medical criteria (clinical guidelines) routine as aspirin + clopidogrel or aspirin +
      ticagrelor, according to medical guidelines currently no other disposal alternative proposal
      (unless adverse drug tolerance or bleeding can not be administered); idea of this experiment
      for acute coronary syndrome or conventional cardiac catheterization after stenting, platelet
      miRNA expression (miR-96 , miR-200b, miR-495, miR-107) after cardiac catheterization and
      interventional treatment of clopidogrel or ticagrelor acceptance of platelet reactivity (PRU)
      correlation values (given clopidogrel or ticagrelor determined by the clinician, the patient
      follow-up experiment to track only and observation), aims to explore under different platelet
      reactivity (hyper-reactive or hypo-reactive), their differences in miRNA performance.
    


Intervention name(s): miRNA within 24hr; miRNA after 1 week; miRNA after 1 month
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): miRNA within 24hr; miRNA after 1 week; miRNA after 1 month
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Diagnostic
Treatment of Rumination by Biofeedback - a Randomized Controlled Trial
Condition: Rumination Disorders
MeSH terms: Rumination Syndrome
Study type: Interventional

Summary: 
      Rumination syndrome is characterized by effortless recurrent regurgitation of recently
      ingested food into the mouth, with consequent expulsion or re-chewing and swallowing. In a
      previous study the investigators showed that rumination is produced by an unperceived,
      somatic response to food ingestion.

      After having identified the key mechanisms of rumination, the investigators developed an
      original EMG guided biofeedback technique with specific targets for correction, based on
      EMG-guided control of abdomino-thoracic muscular activity, and in a pilot study the
      investigators showed the potential effectivity of this treatment. The current aim is to
      validate this previous uncontrolled observation by a formal placebo-controlled, randomized
      trial.
    

Detailed description: 
      Abdomino-thoracic muscle activity after a challenge meal will be recorded by EMG and the
      signal displayed on a monitor and front in the patients: in the biofeedback group, patients
      will be instructed to control muscle activity, whereas in the placebo group patients will
      receive a pill of placebo. In each patient 3 sessions will be performed over a 10-day period.
      Physiological (muscular activity by EMG) and clinical outcomes (number of rumination events
      by questionnaires administered daily for 10 days) will be measured before and after
      treatment.
    

Intervention name(s): Biofeedback; Placebo
Intervention type(s): Behavioral; Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Rumination síndrome; Regurgitation; Vomiting; Biofeedback; Electromyography; Abdominal accommodation
Effects of Pilates Exercises in Squash Players
Condition: Sports Physical Therapy
Study type: Interventional

Summary: 
      To determine the effectiveness of Pilates Exercises on service speed and agility in Squash
      Players
    

Detailed description: 
      Squash was originated in England in the early 19th, when a group of schoolchildren noticed
      that punctured balls could be "squashed" against walls in a wider range of shots and it
      requires more effort from the player. This variation gained popularity, and the first squash
      courts were made in 1864; and the sport of squash was formally formed. Squash is a racquet
      sport in which two players compete with a hollow rubber ball on a court surrounded on four
      sides by walls. The players alternate hitting the ball using racquets. The ball can bounce
      once on the ground and as many times as the court walls allow. Squash players' main approach
      is to compel their opponents to go around the entire playing field. If this tactics is
      successful, the challenger travels a greater distance and puts a higher load on the body.

      The purpose of this study is to determine the effectiveness of pilates exercises on service
      speed and agility in squash players.
    

Intervention name(s): Pilates exercise program group
Intervention type(s): Other
Intervention description(s): Pilates exercise program group will do a warm-up for 10 minutes and then perform five exercises includes standing footwork, hundreds with knee straight, articulating bridge, rolling like a ball, plank for 25 minutes. For first three weeks, each player will do 8 repetitions × 3 sets of exercises and for next three weeks, each player will do 15 repetitions × 3 sets of exercises. There will be cool-down for 10 minutes after exercises. Total program will be of 45 minutes.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Role of Lung Ultrasound In Assessment Of Recruitment Maneuvers In Ventilated Preterms With Respiratory Distress Syndrome and Its Correlation With Tracheal IL-6 Level
Condition: Respiratory Distress Syndrome, Newborn
MeSH terms: Respiratory Distress Syndrome; Respiratory Distress Syndrome, Newborn; Syndrome
Study type: Interventional

Summary: 
      This work is designed to:

        1. Evaluate the efficacy of lung ultrasonography in detecting opening and closing lung
           pressures in ventilated preterm neonates with respiratory distress syndrome.

        2. Determine the efficacy of lung ultrasonography in optimizing lung volume and its
           correlation with pulmonary inflammatory reaction as evidenced by IL-6 level in tracheal
           aspirate.
    

Detailed description: 
      The studied population included 44 preterm infants. Anthropometric measurements, gestational
      age, sex, mode of delivery, maternal disease and Apgar score were found to be matched in the
      two studied groups indicating successful randomization as seen in these balanced demographic
      variables between the groups.

      The studied population included 44 preterm infants. Then they were allocated randomly to one
      of 2 groups in order by admission:

      Group A: included 22 patients on whom the recruitment maneuver was applied guided by lung
      ultrasonography.

      Group B: included 22 patients on whom the recruitment maneuver was not ultrasound guided.
      This is considered the control group.

      Anthropometric measurements, gestational age, sex, mode of delivery, maternal disease and
      Apgar score were found to be matched in the two studied groups indicating successful
      randomization as seen in these balanced demographic variables between the groups.
    

Intervention name(s): lung recruitment maneuver; tracheal IL-6 level; US guided lung recruitment maneuver
Intervention type(s): Other; Other; Other
Intervention description(s): Lung recruitment maneuver done for ventilated preterm neonates diagnosed with respiratory distress syndrome; tracheal IL-6 level was measured before and after recruitment maneuver; Lung recruitment maneuver done for ventilated preterm neonates diagnosed with respiratory distress syndrome guided by lung ultrasound
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The study was conducted on 44 preterm neonates who were mechanically ventilated for respiratory distress syndrome (RDS). Then they were allocated randomly to one of 2 groups in order by admission:
Group A: it included 22 patients on whom the recruitment manoeuvre was applied guided by lung ultrasonography.
Group B: it included 22 patients on whom the recruitment maneuver was not ultrasound guided. This is considered the control group.
Masking: None (Open Label)
Primary purpose: Other
Bioequivalence Study of Pantoprazole Sodium DR Tablets 40 mg of Dr. Reddy's Laboratories Limited Under Fed Condition
Condition: FED
MeSH terms: Malnutrition
Study type: Interventional
Phase: Phase 1

Summary: 
      To compare the single dose bioavailability of pantoprazole sodium 40 mg delayed release
      tablets (Dr. Reddy's Laboratories Ltd, India) with Protonix® 40 mg delayed release tablets
      (Wyeth Laboratories, USA) in 52 (+ 6 standby) healthy, adult, human subjects under fasting
      conditions.
    

Detailed description: 
      This is a Open label, balanced, randomized two-treatment, two-period,two-sequence, crossover
      bioequivalence study with at least 07 days washout period between each drug administration
      under fed conditions.52 (+6 standby) healthy, adult, human subjects were enrolled. A single
      oral dose of 40 mg of pantoprazole delayed release tablet will be administered along with 240
      mL of drinking water within 30 minutes after serving a high fat breakfast.
    

Intervention name(s): Pantoprazole Sodium
Intervention type(s): Drug
Intervention description(s): Pantoprazole Sodium DR Tablets 40 mg
Other intervention name(s): Protonix DR Tablets 40 mg
Intervention MeSH terms: Pantoprazole
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Weight Loss With Exenatide Treatment
Condition: Obesity
MeSH terms: Weight Loss
Study type: Interventional
Phase: Phase 4

Summary: 
      The investigators are conducting a study that will investigate the possible mechanisms of
      weight loss associated with exenatide treatment and the metabolic characteristics of high
      responders (i.e. subjects who achieve greater than 5% weight loss) to exenatide treatment.
      The investigators will also examine the magnitude and duration of weight loss among a cohort
      of high responders over 52 weeks of treatment, and at 3 and 6 months following treatment.

      Hypothesis:

      The mechanisms of weight loss with exenatide are not fully understood, and weight loss
      responses to exenatide are highly variable, possibly reflecting distinct metabolic
      parameters. By identifying and following a group of obese women who lose greater than 5% body
      weight after short-term exenatide treatment, the investigators can gain insights into the
      possible mechanisms of weight loss and assess long-term weight loss with this
      pharmacotherapeutic intervention.
    

Detailed description: 
      Primary Outcomes

      The primary objectives of this study is:

      - To investigate possible mechanisms and patterns of weight loss with exenatide treatment,
      especially among individuals who have robust early weight loss (greater than 5% weight loss
      in 12 weeks) with exenatide.

      Secondary Outcomes

      Our secondary objective is to identify metabolic characteristics that predict robust response
      to exenatide treatment.

      Outcome measurements:

        -  Weight

        -  Body composition

        -  Resting energy expenditure (REE)

        -  Mixed meal test

        -  Thermic effect of food

        -  Serum metabolic parameters

        -  Hunger/Nausea/Satiety visual analog scales (VAS)

        -  Physical activity monitoring

      Study Population

      The study population will be generally healthy, non-diabetic women age 18-70 years with BMI
      28-48 kg/m^2.
    

Intervention name(s): Exenatide; Placebo; Dietary counseling
Intervention type(s): Drug; Drug; Behavioral
Intervention description(s): Subjects will inject 5mcg of exenatide subcutaneously 15 minutes before the morning and evening meal for the first 2 weeks of the study. At study week 2, subjects will increase to 10mcg twice daily for the remainder of the study.; Subjects will inject 5mcg of identically dispensed placebo subcutaneously 15 minutes before the morning and evening meal for the first 2 weeks of the study. At study week 2, subjects will increase to 10mcg twice daily for the remainder of the study.; All subjects will also receive individualized dietary counseling. Subjects in the placebo group will be counseled to follow a hypocaloric diet.
Intervention MeSH terms: Exenatide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Obesity; Overweight; Exenatide; Diet; Women
Gastroenterology Artificial INtelligence System for Detecting Colorectal Polyps (The GAIN Study)
Condition: Colon Adenoma; Colon Polyp; Colon Lesion
MeSH terms: Adenoma; Polyps
Study type: Interventional

Summary: 
      This is a prospective, multicenter, randomized controlled study to evaluate the effect of the
      Computer-Assisted Detection (CADe) Device on Adenomas Per Colonoscopy and Positive Percent
      Agreement for routine colonoscopies. The control arm is colonoscopy performed with High
      Definition White Light Endoscopy (HD-WLE) per standard of care. The intervention arm is
      colonoscopy performed with HD-WLE per standard of care plus the Computer-Assisted Detection
      (CADe) Device.
    


Intervention name(s): Computer-Assisted Detection (CADe) Device
Intervention type(s): Device
Intervention description(s): The CADe Device uses artificial intelligence to aid in identifying colorectal polyps during High Definition White Light Endoscopy (HD-WLE) based colonoscopies. This device connects the Gastroenterologist's colonoscopy video output source to the main monitor and highlights the regions of interest where the device detects a potential lesion. The CADe Device overlays graphical markers onto video from the endoscope camera and does not perform further processing to the endoscope video signal. This device is not intended to replace clinical decision making.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Screening
Intravenous Dexamethasone on Supraclavicular Brachial Plexus Block for Shoulder Arthroscopy
Condition: Shoulder Arthroscopy; Pain
Study type: Interventional
Phase: Phase 4

Summary: 
      Previous studies have confirmed that IV dexamethasone prolongs brachial plexus blocks.
      However, these studies only used fixed doses of IV dexamethasone at relatively high doses,
      which could potentially lead to increased glucose levels, delayed wound healing, and
      unintended side effects. There remains a paucity of research on the effective dose range of
      IV dexamethasone for the prolongation of supraclavicular blocks. The optimal dosage of IV
      dexamethasone for prolongation of analgesia vs. motor block prolongation from supraclavicular
      blocks in shoulder surgery has yet to be delineated.
    

Detailed description: 
      Numerous studies have confirmed that perineural dexamethasone prolongs bupivacaine and
      ropivacaine brachial plexus blocks by approximately 10 hours (from approx. 12 to 22 hours)
      without clinical evidence of toxicity. However, perineural toxicity in an animal model has
      raised concern about its use as a peripheral nerve block adjuvant. Moreover, recent studies
      suggest that high dose IV dexamethasone (810mg) prolongs analgesia to a similar degree as
      perineural dexamethasone for interscalene, supraclavicular and sciatic nerve blocks performed
      with ropivacaine and bupivacaine. However these studies only utilized fixed, high level doses
      of IV dexamethasone. Moreover, there remains a concern that high dose IV dexamethasone may
      lead to postoperative hyperglycemia and could possibly increase the risk of postoperative
      wound infection. Open surgery under general anesthesia has been shown to increase blood
      glucose levels with a peak at approximately 2 hours post-induction and results have been
      conflicting regarding whether or not IV dexamethasone causes greater increase. To the
      investigators' knowledge, it is not yet known if arthroscopic surgery under regional
      anesthesia triggers a similar increase in blood glucose levels and if this is impacted by
      administration of IV dexamethasone. The investigators aim to identify the duration of
      supraclavicular block prolongation that can be expected over a range of doses of IV
      dexamethasone. The investigators also seek to identify what association, if any, is noted
      between IV dexamethasone and changes in blood glucose levels after shoulder surgery with
      regional anesthesia and sedation. Finally, the investigators will collect data on side
      effects and postoperative complications, if any, in patients receiving a range of doses of IV
      dexamethasone.
    

Intervention name(s): IV Saline; IV Dexamethasone 4mg; IV Dexamethasone 6mg; IV Dexamethasone 8mg
Intervention type(s): Drug; Drug; Drug; Drug
Intervention MeSH terms: Dexamethasone; Dexamethasone acetate; BB 1101
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee
Condition: Osteochondritis Dissecans
MeSH terms: Osteochondritis; Osteochondritis Dissecans; Osteochondrosis
Study type: Interventional

Summary: 
      This study plans to learn more about ways to treat a joint problem in the knee called
      Juvenile Osteochondritis Dissecans (OCD). The goal of this study is to see if injecting
      platelet-rich plasma (PRP) into the knee can help knee cartilage heal faster, and will try to
      determine whether the injections lead to improvements in pain, performance of activities of
      daily living, improvements is sports activities and overall function and symptoms reduction.
      The investigators will compare PRP treatment to conservative therapy.
    


Intervention name(s): Platelet rich plasma (PRP)
Intervention type(s): Drug
Intervention description(s): Patient will receive 3 intra articular injections with autologous PRP in the affected knee and then follow conventional therapy.
Other intervention name(s): autologous PRP
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Arm 1- Conservative Treatment Arm 2- PRP Injections
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Study on the Treatment of Soft Tissue Sarcoma With First-line Chemotherapy Failure by Anrotenil Hydrochloride Capsule
Condition: Soft Tissue Sarcomas
MeSH terms: Sarcoma
Study type: Interventional
Phase: Phase 4

Summary: 
      Soft tissue sarcoma STS is a group of malignant tumors derived from connective tissue other
      than bone and cartilage. It can occur in any part of the body at any age, and there is no
      significant gender difference.According to pathological classification, STS has 19 tissue
      types and more than 50 disease subtypes.Currently, surgical resection, radiotherapy and drug
      therapy are the main treatment methods.But about 50% of the patients with distant metastasis
      happened not the surgical removal of, quite a number of in patients with distant metastasis
      after died of disease progression 8-12 months in drug treatment of soft tissue sarcoma, the
      current widely used chemotherapy regimens for ADM/IFO single-agent or joint IFO ADM is a line
      of chemotherapy, in addition, paclitaxel, gemcitabine, dorsey race, it was also used for soft
      tissue sarcomas of second-line chemotherapy scheme, however, for some special subtypes of
      sarcoma,Such as myxoid liposarcoma, pleomorphic rhabdomyosarcoma, leiomyosarcoma, glandular
      soft tissue sarcoma and superficial malignant fibrous histiocytoma, are not sensitive to
      chemotherapy or low sensitivity.Therefore, how to improve the survival rate of these patients
      is an urgent problem to be solved.

      Anlootinib hydrochloride is a multi-target tyrosine kinase inhibitor that has shown good
      efficacy in solid tumors such as NSCLC, ovarian cancer, soft tissue tumors, and medullary
      thyroid cancer.Especially in the field of soft tissue sarcomas, the results of phase IIb
      clinical data were satisfactory.Therefore, Investigator plan to conduct the study of
      anrotenil hydrochloride capsule for the treatment of soft tissue sarcomas with first-line
      chemotherapy failure (anthracycline)
    


Intervention name(s): Anlotinib Hydrochloride
Intervention type(s): Drug
Intervention description(s): The standard first-line chemotherapy regimen (adriamycin + ifosfamide) failed
Other intervention name(s): Oral administration of single drug on an empty stomach
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment