bioihbjkbjnl/mcl2 huggingface dataset:
Factors Affecting the Effective End-tidal Concentration of Desflurane Anaesthesia
Condition: General Anesthetic Drug Adverse Reaction
MeSH terms: Drug-Related Side Effects and Adverse Reactions
Study type: Interventional

Summary: 
      There is accumulating evidence that inappropriate depth of anaesthesia is associated with
      increased risk of postoperative complications including risk of death. The aim of this study
      was to identify factors determining the effective end-tidal concentration (EEtC) of
      desflurane, duration of wash in and wash out phase, and to estimate the risk of perioperative
      awareness in patients undergoing elective neurosurgical procedure.
    

Detailed description: 
      All patients with American Society of Anesthesiologists (ASA) physical status I-III scheduled
      for elective neurosurgical procedure under general anaesthesia are studied. In each
      individual, the manufacturer recommended age-corrected end-tidal concentrations of desflurane
      is set and achieved initially. Individual effective end-tidal concentration (EEtC) of
      desflurane is then defined according to entropy parameters and maintained in the targeted
      range of static and response entropy 40-50. Effective analgesia is maintained according to
      surgical plethysmographic index (SPI) and dose of muscle relaxants according to neuromuscular
      transmission monitoring (TOF). Comorbidity, regular intake of alcohol and medication,
      smoking, sex, weight, height, and age are recorded. Postoperative questionnaire is used to
      reveal the intraoperative awareness.
    

Intervention name(s): desflurane - oxygen in air; desflurane - oxygen in nitric oxide
Intervention type(s): Drug; Drug
Intervention description(s): The manufacturer recommended age-corrected end-tidal concentrations of desflurane in air should be set and achieved initially. Individual EEtC of desflurane will be defined according to entropy parameters and maintained in the targeted range of static and response entropy 40-50; The manufacturer recommended age-corrected end-tidal concentrations of desflurane with nitric oxide - oxygen should be set and achieved initially. Individual EEtC of desflurane will be defined according to entropy parameters and maintained in the targeted range of static and response entropy 40-50
Other intervention name(s): suprane; suprane
Intervention MeSH terms: Nitric Oxide; Desflurane
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Desflurane; end tidal concentration; age; anesthesia
Efficacy and Safety of Terlipressin With Albumin Versus Midodrine With Albumin Versus Albumin Alone in Prevention of Paracentesis Induced Circulatory Dysfunction in Cirrhosis
Condition: Cirrhosis
MeSH terms: Liver Cirrhosis; Fibrosis
Study type: Interventional

Summary: 
      -  Study Population: Patients admitted or seen in Out Patient Department, Department of
           Hepatology, Institute of Liver and Biliary Sciences.

        -  Study Design: Prospective Open Labeled Randomized Controlled Trial.

        -  Study Period: January 2017 to December 2017

        -  Intervention- Subjects will be randomized to 3 groups

        -  All patients will receive Standard medical therapy - Albumin-8g/L of tap- one half of
           dose at beginning of tap and rest half after 6 hours of tapping.

      Group A - Subjects will receive Terlipressin 1mg intravenous bolus at the onset of
      paracentesis and the remaining as 1 mg doses intravenous at 8 and 16 h after the first dose.
      ( total -3mg) Group B - Midodrine 7.5 mg TDS x 3 days Group C - Standard medical therapy only

        -  Monitoring and Assessment: Clinical evaluation will be done at regular intervals.

        -  Adverse Effects: Rise in blood pressure, arrthymias, hyponatremia and rarely
           cardiovascular side effects have been noted.

        -  Stopping Rule: Development of PICD, hypertension ( BP>160/90mmhg-JNC class II)
    


Intervention name(s): Terlipressin; Midodrine; Albumin
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Terlipressin 1mg intravenous bolus at the onset of paracentesis and the remaining as 1 mg doses intravenous at 8 and 16 h after the first dose. ( total -3mg); Terlipressin 1mg intravenous bolus at the onset of paracentesis and the remaining as 1 mg doses intravenous at 8 and 16 h after the first dose. ( total -3mg); Albumin-8g/L of tap- one half of dose at beginning of tap and rest half after 6 hours of tapping.
Intervention MeSH terms: Terlipressin; Midodrine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Flunisolide HFA in Children With Small Airway Disease
Condition: Childhood Asthma
Study type: Interventional

Summary: 
      The purpose of this study is to see how two doses of Flunisolide HFA (an FDA approved inhaled
      medication to treat asthma) affect the small airways in children with asthma.
    

Detailed description: 
      This is a prospective, randomized, parallel, open label study. The primary aim is to compare
      the average change in spirometric values (Forced expiratory volume 1 (FEV1) and Forced
      Expiratory Flow 25-75% (FEF 25-75%) and Impulse Oscillometry System (IOS) values (Resistance
      at 5 Hz (R5), Resistance at 20 Hz (R20), Area of reactance (AX), Resonant frequency (Fres))
      from baseline to week 6 from participants randomized flunisolide hydrofluoroalkane (HFA) 1
      inhalation BID and to flunisolide HFA 2 inhalations BID. The change in scores from baseline
      to six week follow up will initially be compared using paired t-tests and Chi-squared tests
      for trend. Repeated measurements will be analyzed using generalized linear mixed-effects
      regression modeling (GLMM) techniques. For continuous outcomes (e.g. FEV1, FEF 25-75%, Fres,
      reactance at 5 Hz (X5), AX, R5-R20). The identity link function and normal distribution will
      be used. For count data (e.g., use of Beta-agonists, episodes of coughing, episodes of
      wheezing, etc.) the log link function and the Poisson distribution will be used. If we
      dichotomize outcomes (e.g., a Beta-agonist was used, coughing occurred, etc.) the logit link
      function and Bernoulli distribution will be used.
    

Intervention name(s): Flunisolide HFA
Intervention type(s): Drug
Intervention MeSH terms: Flunisolide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Very Low Frequency Magnetic Fields in the Treatment of Fibromyalgia
Condition: Fibromyalgia
MeSH terms: Fibromyalgia; Myofascial Pain Syndromes
Study type: Interventional

Summary: 
      The purpose of the study is to determine the effectiveness of treatment with very low
      frequency electromagnetic fields on the reduction of pain in patients with fibromylgia,
      disease presenting with widespread musculoskeletal pain usually associated with other
      symptoms such as stiffness, fatigue, sleep disturbances, depression, anxiety.
    


Intervention name(s): Very Low Frequency Magnetic Fields; Very Low Frequency Magnetic Fields
Intervention type(s): Device; Device
Intervention description(s): The device is set to an analgesic program lasting about 30 minutes.; The device is turned off.
Other intervention name(s): ELF; ELF
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Fibromylgia; Magnetic Fields; Pain; Visual Analogue scale
Study of Patient Navigation to Promote Colon Cancer Screening
Condition: Colorectal Cancer Screening
MeSH terms: Colorectal Neoplasms
Study type: Interventional

Summary: 
      This study will investigate whether patient navigation can increase rates of colorectal
      cancer screening among linguistically and culturally diverse disadvantaged patients served by
      urban community health centers.
    


Intervention name(s): Patient navigation; Usual care
Intervention type(s): Other; Other
Intervention description(s): Letter and Colorectal Cancer Screening Brochure mailed to patients. Telephone outreach by Patient Navigators.; Usual care
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Screening
Keywords: community health centers; colorectal cancer screening; urban health
Effectiveness of Virtual Reality in Hand Therapy
Condition: Distal Radius Fracture; Chronic Regional Pain Syndrome; Flexor Tendon Rupture
MeSH terms: Rupture; Radius Fractures; Wrist Fractures
Study type: Interventional

Summary: 
      The purpose of this study is to determine if the use of Virtual Reality as an intervention
      for patients following specific hand injuries will positively affect patients with decreased
      hand function and reduce pain and improve outcomes. Participants will be recruited from 3
      different clinics in central Kentucky.
    

Detailed description: 
      Participants will participate in four sessions of therapy treatment over a 2-3 week time span
      of schedule therapy appointments during their active phase of rehabilitation for
      approximately 1-hour virtual reality (VR) training dosage which will be recorded. The
      specific virtual reality games within the Oculus Quest 2 VR system will be selected by the
      therapist providing interventions each session.

      In addition to the Virtual Reality intervention noted above, participants will participate in
      a pre and post-test outcome measure session (25-30 minutes) with a research team member. (See
      outcome measure section for more details).
    

Intervention name(s): Virtual Reality Exercises
Intervention type(s): Other
Intervention description(s): Hand Therapy Exercises utilizing Oculus Quest 2 VR system with augmented feedback for patient to perform active hand therapy. Specific interventions / games will be selected by the participants individual therapist.
Intervention model: Single Group Assignment
Intervention model description: Participants at the Commonwealth Hand and Physical Therapy clinic with the 3 included arm and hand injury diagnoses will be offered the opportunity in a flyer at the clinic to participate in the VR study. Those consented will complete the pre and post outcome measures outlined within this document with the research team member. For intervention, the participants will be instructed by the treating therapist in standard of care rehabilitation and utilize Virtual Reality with the Oculus Quest 2 system as the active exercise component of their rehabilitation over approximately approximately 4 sessions, totally ~ 1-hour. The specific virtual reality games within the Oculus Quest 2 VR system will be selected by the therapist providing interventions each session. The virtual reality game allows for augmented visual feedback and will be directly supervised by the treating therapists.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Virtual Reality; Function; Hand Therapy; Exercises
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Ivacaftor in Subjects With Cystic Fibrosis Who Are Less Than 24 Months of Age and Have an Ivacaftor-Responsive CFTR Mutation
Condition: Cystic Fibrosis
MeSH terms: Cystic Fibrosis; Fibrosis
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study was to evaluate the safety of ivacaftor treatment, and PK of
      ivacaftor and metabolites in participants with cystic fibrosis (CF) who are <24 months of age
      at treatment initiation and have an ivacaftor-responsive CF transmembrane conductance
      regulator (CFTR) gene mutation.
    


Intervention name(s): IVA
Intervention type(s): Drug
Intervention description(s): Granules in sachet for oral administration.
Other intervention name(s): VX-770; ivacaftor
Intervention MeSH terms: Ivacaftor
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Diagnostic Assessment and Intervention Study of Amphetamine Type Stimulus
Condition: Amphetamine Addiction
MeSH terms: Amphetamine-Related Disorders
Study type: Interventional

Summary: 
      The purpose of this research is to inspire new medical ideas using brain image technology for
      the treatment of Amphetamine Type Stimulus addition, at the same time lowing the addition
      damage.
    

Detailed description: 
      The study will increase the sample size based on the preliminary work,also, establish drug
      dependence induced craving associated environmental experiments , by using the multi-lead
      biofeedback instrument , CogState tester, event-related potentials Recorder and 3.0T
      high-field magnetic resonance imaging system to record the physiology , electrophysiology and
      brain changes during craving, taking a subjective self-assessment , clinical observations and
      physiological responses combined system to evaluate the ATS addiction degree.
    

Intervention name(s): psychological rehabilitation training; physical and neurological rehabilitation training; rTMS 10HZ high frequency stimulation; fake rTMS 10HZ high frequency stimulation
Intervention type(s): Behavioral; Behavioral; Radiation; Radiation
Intervention description(s): The main content is self-awareness training, social and moral strengthening, impulse control training , problem solving training , situational awareness training , HIV prevention, social skills training under the family atmosphere , family social skills training , interpersonal skills training, community interaction skills training , psychiatric symptoms of self-monitoring skills training and so on.; The main content is drug rehabilitation exercise and functional physical training. Rehabilitation led by the discipline cadres , practice once a day, each lasting about 15 minutes .; Stimulate the dorsolateral prefrontal and parietal lower part , 4 weeks of therapeutic intervention (5 times / week).; Fake stimulate the dorsolateral prefrontal and parietal lower part , 4 weeks of therapeutic intervention (5 times / week).
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: drug carving changes during rehabilitation; community; DNA
Long-term With a Trifocal Intraocular Lens
Condition: Cataract
MeSH terms: Cataract
Study type: Observational

Summary: 
      The main aims of this study were to evaluate the patient reported outcomes (PROs), safety and
      efficacy, after 6-year (66 - 78 months) from the binocular implantation of the AT LISA tri
      839MP. A secondary aim was to evaluate new metrics such as contrast sensitivity defocus
      curves and light distortion analysis.
    

Detailed description: 
      Retrospective cross-sectional study with two stages:

      • Phone call interview:

      First stage included patient reported outcomes of visual function, spectacle independence and
      satisfaction through questionnaires conducted by a phone call in all the patients implanted
      in our center with AT LISA 839MP from March 2014 to June 2015 (n=92) which accomplished
      inclusion / exclusion criteria and were able to be contacted by phone (n=62).

      The incidence of Nd-YAG capsulotomy was retrospectively evaluated through the revision of the
      medical history, in patients for which capsulotomy was conducted in our center, or a
      question, for those treated in another center.

      • Study visit:

      Second stage included the consecutive invitation of these phone interviewed patients to a
      visit in our center for a long-term visual performance assessment up to accomplish the
      required sample size (n=37).

      Corrected and uncorrected monocular visual acuities were the primary end-points for testing
      non-inferiority hypothesis in comparison to 12-month follow-up mean results reported in the
      literature. Secondary variables of assessment were contrast sensitivity defocus curve and
      light distortion analysis.
    

Intervention name(s): AT LISA tri 839MP
Intervention type(s): Device
Intervention description(s): Non interventional study
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Patients implanted with AT Lisa Tri from March 2014 to June 2015
      
Keywords: Multifocal intraocular lens; Long-term; Safety; Efficacy; Defocus curve; Light distortion
A New Model of Acute Febrile Disease
Condition: Immobilization, Tonic; Fasting; Endotoxemia; Metabolism
MeSH terms: Endotoxemia
Study type: Interventional

Summary: 
      The investigators want to establish a new model of acute febrile disease by mimicking the
      conditions seen in hospitalized patients in regards to inflammation, immobilisation and
      fasting. In this new model of disease, healthy young adults will be given lipopolysaccharide
      (LPS) to induce endotoxemia and inflammation/fever and then fast and bedrest for 36 hours.
      Glucose, fat and protein metabolism will be investigated using clamp technique and tracer
      methodology together with intracellular signalling pathway activation in muscle and fat
      biopsies. This new model of disease will later be used in another study to investigate
      different protein supplement´s effect on muscle waste during acute febrile disease.
    

Detailed description: 
      The investigators want to establish a new model of acute febrile disease by mimicking the
      conditions seen in hospitalized patients in regards to inflammation, immobilisation and
      fasting. In this new model of disease, healthy young adults will be given lipopolysaccharide
      (LPS) to induce endotoxemia and inflammation on study day 1 and then fast and bedrest for 36
      hours (Study day 2). Glucose, fat and protein metabolism will be investigated using clamp
      technique and tracer methodology together with intracellular signalling pathway activation in
      muscle and fat biopsies. This new model of disease will later be used in another study to
      investigate different protein supplement´s effect on muscle waste during acute febrile
      disease.
    

Intervention name(s): LPS, 36 hour immobilization and fast
Intervention type(s): Other
Intervention description(s): LPS endotoxin is administered on study day 1 and immobilization and fast continue throughout study day 1 and 2.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Healthy young adults will be randomized to either intervention "Endotoxemia, 36 hour immobilization and fasting" or "overnight fast" being the control day.
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: immobilization; fasting; endotoxemia; LPS; metabolism; model of disease
Effect of Azimilide Dihydrochloride on Renal Function
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will assess the effect of multiple dosing of 125 mg azimilide on glomerular
      filtration rate (GFR) and total creatinine clearance (GFR + active secretion) in healthy
      subjects. Also, it will assess the effect of multiple dosing of 125 mg azimilide on renal
      hemodynamics (RPF) in healthy subjects.
    

Detailed description: 
      This is a double-blind, parallel-group, placebo-controlled, multiple-dose, single-site study
      in healthy male and female volunteers. Oral azimilide 125 mg or placebo will be administered
      every 12 hours for 3 days, followed by 125 mg every 24 hours for 3 days. The study will
      include a total of 21 healthy subjects (14 active and 7 placebo), all of whom will be
      confined at the study center for 9 nights.
    

Intervention name(s): Azimilide dihydrochloride; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 125 mg azimilide tablet every 12 hours for 3 days followed by 125 mg azimilide tablet every 24 hours for three days; Placebo tablet every 12 hours for 3 days followed by placebo tablet every 24 hours for three days
Intervention MeSH terms: Azimilide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Dual-Task Effects on Hand Functions in Type 2 Diabetes Mellitus
Condition: Type 2 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      The aim of the study is to examine the effect of dual-task performance on hand functions in
      individuals with Type 2 Diabetes Mellitus. It is planned to reach at least 100 participants
      during the data collection phase of the study. Demographic information, plasma glucose
      levels, and HbA1C levels of the participants included in the study will be recorded. The
      upper extremity problems of the participants will be recorded. Minnesota Manual Dexterity
      Test will be used to evaluate upper extremity functions.
    

Detailed description: 
      This study is aimed to evaluate the effect of dual-task performance on hand functions in
      individuals with Type 2 Diabetes Mellitus. The study will conduct in the Internal Medicine
      Clinic of Kutahya Health Sciences University Evliya Celebi Training and Research Hospital.
      Approval for the study was granted by the Clinical Research Ethics Committee of Kutahya
      Health Sciences University and written informed consent forms will be obtained from all the
      participants. This study is planned to reach at least 50 participants with type 2 diabetes
      mellitus for the study group and 50 participants without diabetes for the control group. The
      participants will be questioned about their eligibility for the inclusion criteria. The
      demographic and descriptive data of the participants will be recorded. Minnesota Manual
      Dexterity Test will be used to evaluate upper extremity functions. The test will be performed
      with and without the dual-task. Counting backward from a random three-digit number 3 by 3
      will be used for the dual-task. The effect of dual-task will calculate using the difference
      between the completion time of both tests for both groups.
    

Intervention name(s): Dual-task
Intervention type(s): Other
Intervention description(s): In the study, both groups are going to evaluate with and without dual-task. The dual-task will be counting back down 3 by 3 from a three-digit number.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Other
Keywords: type 2 diabetes; dual-task; hand functions
A Study of LY900014 Formulation in Participants With Type 1 Diabetes Mellitus Using Insulin Pumps
Condition: Diabetes Mellitus, Type 1
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Interventional
Phase: Phase 1

Summary: 
      This study evaluated a blood sugar lowering insulin, LY900014, delivered by an insulin pump
      continuously under the skin. The study was conducted in participants with type 1 diabetes
      mellitus to investigate how the human body processed LY900014 and its effect on blood sugar
      levels when it was delivered via an insulin pump. Side effects and tolerability were be
      documented.
    


Intervention name(s): LY900014; Insulin Lispro
Intervention type(s): Drug; Drug
Intervention description(s): Administered subcutaneously (SC); Administered SC
Other intervention name(s): Ultra-Rapid Lispro
Intervention MeSH terms: Insulin Lispro
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science