bioihbjkbjnl/mcl2 huggingface dataset:
Radiation Exposure Reduction in Supraventricular Tachycardia Ablation
Condition: Supraventricular Tachycardias
MeSH terms: Tachycardia; Tachycardia, Supraventricular
Study type: Interventional
Phase: Phase 4

Summary: 
      Radiofrequency catheter ablation (RFCA) is the mainstay of therapy for supraventricular
      tachyarrhythmias, providing cure in a high percentage of cases. Conventional ablation
      techniques require the use of fluoroscopy to place and navigate catheters in the heart, thus
      exposing patients to ionizing radiations with an additional risk of cancer. The feasibility
      and safety of a non-fluoroscopic RFCA of a wide range of supraventricular arrhythmias using
      the EnSite NavX mapping system have been recently reported. The NO-PARTY is a multicenter,
      randomized-controlled trial designed to test the hypothesis that supraventricular arrhythmias
      RFCA through the non-fluoroscopic EnSite NavX mapping system results in a clinically
      significant reduction of the exposure to ionizing radiations compared with conventional
      ablation techniques.

      NO-PARTY trial will determine whether supraventricular tachyarrhythmia RFCA through a
      non-fluoroscopic EnSite NavX mapping system is a suitable and cost-effective approach to
      achieve a clinically significant reduction of ionizing radiation exposure for both the
      patient and the operator.
    


Intervention name(s): Radiofrequency catheter ablation; Radiofrequency catheter ablation
Intervention type(s): Procedure; Procedure
Intervention description(s): Conventional radiofrequency catheter ablation through fluoroscopic guidance of supraventricular arrhythmias.; Radiofrequency catheter ablation through the non-fluoroscopic EnSite NavX mapping system (St.Jude Medical, St Paul, MN, USA) guidance.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Supraventricular arrhythmia catheter ablation
Effect of Breathing and Muscle Relaxation Technique in Individual With Essential Hypertension
Condition: Essential Hypertension
MeSH terms: Hypertension; Essential Hypertension
Study type: Interventional

Summary: 
      Primary hypertension, also called essential hypertension, is a rise in blood pressure (BP)
      with no identifiable cause. The most prevalent form of hypertension is essential
      hypertension, which involves 95% of patients with hypertension.Progressive muscle relaxation
      (PMR) is learning to relax some groups of muscles while paying attention to the feelings
      connected with both the tense and relaxed states.It is generally established that regular
      slow (deep) breathing exercises enhance respiratory and cardiovascular function by enhancing
      parasympathetic tone and reducing sympathetic activity, thus reducing BP, heart rate,
      respiratory rate, and stress levels in hypertensive patients. This study aimed to investigate
      the combined effect of slow breathing and PMR technique on BP, heart rate, respiratory rate,
      and anxiety in patients diagnosed with essential hypertension.
    

Detailed description: 
      From the previously published literature, it is obvious that both slow breathing and PMR and
      slow breathing is effective in patients with essential hypertension. However, no studies are
      available on the combined effect of these two techniques. So, the study aims to investigate
      the combined effect of slow breathing and PMR technique on BP, heart rate, respiratory rate,
      and anxiety in patients diagnosed with essential hypertension.

      Sixty-four participants diagnosed with essential hypertension were randomly allocated into
      four groups (Slow breathing (SB), PMR, SB+PMR, Control) with 16 subjects in each. Baseline
      BP, HR, RR and perceived stress scale were taken. All three-intervention groups underwent 30
      minutes of training three days before the day of the intervention. The intervention consisted
      of 30 minutes, pre, mid and post-intervention BP, HR, RR and Perceived Stress (PS) were
      measured. The control group rested for 30 minutes. Pre, mid and post-rest measurements of BP,
      HR, RR and PS were taken.
    

Intervention name(s): Slow Breathing Exercise (SBE); Progressive Muscle Relaxation (PMR) Technique
Intervention type(s): Other; Other
Intervention description(s): Slow Breathing Exercise (SBE) delivered in a relaxed supine posture on a couch with keeping the feel flat and knee flexed to 90 degree.
Participants were instructed to make six breaths per minute for 30 minutes per session, twice a week for 4 weeks.; Progressive Muscle Relaxation (PMR) Technique delivered in a relaxed supine posture on a couch with keeping the feel flat and knee flexed to 90 degree.
Participants were instructed to complete all sixteen steps of PMR technique for 30 minutes per session, twice a week for 4 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
A Study of LY3457263 Alone and in Combination With Dulaglutide (LY2189265) in Participants With Type 2 Diabetes
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      The main purpose of this study is to investigate the safety and tolerability of the study
      drug LY3457263 when administered alone or in combination with glucagon-like peptide 1 (GLP-1)
      receptor agonist (RA) in participants with type 2 diabetes. Blood tests will be performed to
      investigate how the body processes the study drug and how the study drug affects the body.
      The study will last up to approximately 16 weeks excluding the screening period for each
      participant and include up to 17 visits.
    


Intervention name(s): LY3457263; Placebo; Dulaglutide
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Administered SC.; Administered SC.; Administered SC.
Other intervention name(s): LY2189265
Intervention MeSH terms: Dulaglutide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Catheter Resistance Monitoring to Predict Catheter-Associated Adverse Events in Children and Adolescents
Condition: Cancer; Hematologic Disorders
MeSH terms: Hematologic Diseases
Study type: Observational

Summary: 
      Catheter occlusion and dysfunction are common complications of central venous access device
      (CVAD) use in children with cancer and hematologic disorders. These events can lead to
      interruption of therapy and may require device removal and replacement. Attempts to clear
      occlusion can cause device fracture.

      There is a clear link between catheter occlusion and other serious complications including
      bloodstream infection and intravascular thrombosis.

      There is evidence that catheter occlusion or dysfunction may be preceded by subclinical
      catheter narrowing, which could be detected by accurate measurement of catheter resistance.

      This study aims to observe and describe the feasibility and results of catheter resistance
      monitoring (CRM) over time with the aim of prospectively identifying patients at high risk of
      catheter occlusion.

      If CRM is feasible and proves to be sensitive and specific, it could provide an opportunity
      for preemptive therapy to prevent occlusion, which might also prevent bloodstream infection
      or thrombosis.
    

Detailed description: 
      Weekly measurement of catheter resistance will be determined using the Alaris® Syringe Module
      (Carefusion Inc., San Diego, USA), a commercially available, FDA-approved intravenous (IV)
      pump which is able to deliver accurate flow-rates and obtain accurate pressure measurements.
      The inline pressure will be measured at multiple flow-rates and resistance will be estimated
      from the gradient of the pressure-flow curve.

      Primary Objective

        -  To describe the feasibility of weekly CRM in children and adolescents treated at St.
           Jude.

      Secondary Objectives

        -  To describe patient and caregiver adherence with weekly CRM in children and adolescents
           treated at St. Jude.

        -  To explore the correlation between results of CRM and catheter occlusion or dysfunction.
    

Intervention name(s): Catheter Resistance Monitoring
Intervention type(s): Other
Intervention description(s): Weekly measurement of resistance to flow in the lumen(s) of a CVAD with the commercially available Alaris® Syringe Module IV pump. The aim is to identify an increase in resistance greater than normal variation. Inline pressure measurements will be recorded at multiple flow-rates and resistance will be estimated from the gradient of the pressure-flow curve.
Other intervention name(s): CRM
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Participants will be drawn from current St. Jude patients who have a central venous access
        device already in place as part of their standard clinical care.
      
Keywords: Central venous access device; Catheter resistance monitoring
Internet App to Self-Manage Occasional Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      Nonspecific low back pain (NLBP) is the diagnosis for 85% of low back pain sufferers with no
      underlying medical cause (e.g., herniated disc, spinal stenosis) that requires physician
      care. Treatment, however, is impractical for many physicians to implement during office
      visits, and there are relatively few providers for NLBP treatment that follow national pain
      control guidelines. This study evaluated the efficacy of an on-line intervention using
      desktop computers or mobile technology to help users self treat NLBP occurrences and to
      engage in activities to decrease future occurences.
    

Detailed description: 
      Methods. A total of 606 adults, 18 years of age and older were recruited, screened, and
      consented online. They were assessed on-line at baseline, at two months weeks, and at four
      months After the baseline assessments, participants were randomized into NLBP treatment (TX),
      alternative website control (AWC), and no-contact control groups. The TX and AWC groups
      received 8 weekly emails prompt to visit their respective experimental websites.

      Add Details here.
    

Intervention name(s): FitBack on-line intervention; Alternative Website Control
Intervention type(s): Behavioral; Other
Intervention description(s): On-line Fitback intervention: Self care for on-going pain; behaviors to lessen the chance of reoccurrence; Intervention is a Menu of links to 4 popular Websites offering back pain education
Other intervention name(s): Fitback app
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: low back pain; internet; app; prevention; treatment
Comparing 18F-FAPI-04 and 18F-FDG PET/CT in Cancer Detection
Condition: Malignant Neoplasm
MeSH terms: Neoplasms
Study type: Interventional

Summary: 
      Evaluating fluoro-18-fibroblast activation protein inhibitor-04 positron emission computed
      tomography's diagnostic efficacy for primary malignancies versus
      18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose.
    

Detailed description: 
      In recent years, radionuclide labeled fibroblast activating protein inhibitors (FAPIs) have
      gradually become a new strategy for targeted diagnosis and therapy. In this study,
      radionuclide 18F was used to label FAPI, and the imaging value of FAPI was compared with that
      of common developer 18F-FDG. To evaluate the diagnostic value of 18F-FAPI-04 PET/CT in
      various malignant tumors.
    

Intervention name(s): PET/CT
Intervention type(s): Diagnostic Test
Intervention description(s): Low-dose CT images were first collected during scanning. The tube voltage was 120kilovolt, the tube current was 50-220Milliampere and the layer thickness was 3.75mm.
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Diagnostic
Keywords: 18F-FDG; 18F-FAPI; PET/CT
Comparison of TrIfecta and Perimount Magna Ease
Condition: Aortic Xenograft Hemodynamics
Study type: Interventional

Summary: 
      The hemodynamic performance of two supraannular aortic xenografts (Trifecta, St. Jude Medical
      and Perimount Magna Ease, Edwards Lifescience) will be compared using rest- and stress
      echocardiography in a randomized prospective study. Furthermore, the prostheses' influence on
      postoperative outcome will be compared using spiroergometry, quality of life questionnaire
      and heart failure biomarkers.
    


Intervention name(s): Aortic xenograft
Intervention type(s): Device
Intervention description(s): After randomization, the aortic xenograft is implanted in the standard fashion
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Non-Linear Imaging of Skin In Vivo
Condition: Skin Cancer; Skin Condition; Skin Diseases; Skin Lesion; Skin Abnormalities
MeSH terms: Skin Abnormalities; Skin Diseases
Study type: Observational

Summary: 
      The overall objective of this study is to investigate the potential for the VIO System to
      display microscopic skin structure in people of different age, sex, race, and skin health.
    


Intervention name(s): VIO System
Intervention type(s): Device
Intervention description(s): To investigate the potential for the VIO System to display microscopic skin structure in people of different age, sex, race, and skin health
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Healthy subjects, volunteers as well subjects with suspected skin condition recruited from
        dermatology clinics
Effect of Proprioceptive Exercises on Pain and Function in Non-specific Chronic Neck Pain
Condition: Neck Pain
MeSH terms: Neck Pain
Study type: Interventional

Summary: 
      This study was conducted to see the effect of proprioceptive exercises on pain and function
      in Non-specific chronic neck pain.

      Twenty participants with chronic Non-specific neck pain were enrolled in this study. During
      the final week of treatment, 14 patients were assessed at the end of the sixth treatment
      week. Participants were randomized into two groups treatment group and control group. Both
      groups were treated with conventional treatment which were strengthening exercises. Treatment
      group was also treated by proprioception exercises. For measurement of pain and disability
      NPRS and NDI scales were used. Exercise regime distributed in six weeks period one session
      per week exercise, 10-12 repetitions with 1-minute rest interval, lasted 45 minutes in both
      groups. pre-treatment and post-treatment measurements were taken.
    


Intervention name(s): proprioceptive exercises; Strengthening exercise
Intervention type(s): Other; Other
Intervention description(s): proprioception exercises included (a)Head relocation it involve the practice of relocating head back to natural head posture and to predetermined positions in range first with eyes open using feedback from a laser attached to their head and then with closed all active movement of cervical flexion extension lateral flexion and rotations were used.(b)Gaze stability oculomotor exercises commencing with eyes movement with the head stationary ,progressing to movement of head with visual fixation on a target. (c) Eye head coordination exercises, commenced with rotation of eyes and head to the same side in both right and left directions. Then progressed with both eyes and head move in opposite direction; strengthening exercises which are performed with prone and supine position by placing a towel under head, press towel for 5 seconds with 10-12 repetitions ,one set in a week for six weeks for cervical muscles
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Neck disability index,; Numerical pain rating scale; Proprioceptive exercise
Research in Autism: Parent Intervention
Condition: Autistic Disorder
MeSH terms: Autistic Disorder
Study type: Interventional

Summary: 
      The purpose of this research project was to systematically compare two widely used types of
      intervention programs for children with autism within a parent training model. In one
      condition, randomly assigned children were provided with an intervention that typically
      results in acquisition of expressive words in a large percentage of children diagnosed as
      having autism, using a well-documented manualized intervention focused on verbal expressive
      communication only (Pivotal Response Training, PRT). In the other condi¬tion, randomly
      assigned children received a widely used intervention on the same social communication
      functions using a well-documented manualized augmentative system of intervention (Picture
      Exchange Communica¬tion System, PECS) that has been reported to produce verbal and nonverbal
      communication in large percentages of children diagnosed with autism. Children in the two
      conditions were compared for development of verbal and nonverbal communication, changes in
      disruptive behavior, changes in symptoms of autism, and general adaptive behavior gains. In
      addition, parent satisfaction and stress measures were gathered in order to assess the
      effects of each intervention on family functioning.
    


Intervention name(s): Pivotal Response Training; Picture Exchange Communication System
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Naturalistic behavioral protocol designed to teach vocal communication.; Pictorially-based behavioral protocol designed to teach communication to nonverbal children via pictures icons.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Communication; Pivotal Response Training; Picture Exchange Communication System
Intra Versus Extra-thoracic Oscillations in Chronic Obstructive Pulmonary Disease
Condition: Chronic Obstructive Pulmonary Disease
MeSH terms: Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Study type: Interventional

Summary: 
      Chronic Obstructive Pulmonary Disease (COPD) is the fourth-leading cause of death. It is a
      progressive illness that requires life-long treatment.Promoting airway clearance (AC) using
      mucolytics together with airway clearance techniques (ACTs) form the basis for pulmonary
      therapy in COPD care.Therefore, new airway clearance modalities are required to decrease the
      detrimental effects of accumulated secretions in COPD.

      One of the devices used in AC is the high frequency chest wall oscillation (The Vest). HFCWO
      involves the use of an inflatable vest/jacket that covers the chest and is attached to an air
      pulse-generating compressor which rapidly inflates and deflates the vest, producing
      oscillations to the chest wall of 5-25 Hz.

      Another new airway clearance modality is oscillating positive expiratory pressure(Quake)
      which combines PEP therapy with high frequency oscillations.
    

Detailed description: 
      The present study aimed to evaluate the effectiveness of the extra thoracic oscillations via
      high frequency chest wall oscillation vest (HFCWO) versus the intra thoracic oscillations via
      oscillatory positive expiratory pressure (OPEP) Quake device in COPD Group A: consists of 30
      patients will be treated by high frequency chest wall oscillation vest along with their
      prescribed medical treatment. This program will be performed 4 times per week for 6
      successive weeks.

      Group B: consists of 30 patients will be treated by vibratory PEP (The Quake) along with
      their prescribed medical treatment. This program will be performed 4 times per week for 6
      successive weeks.
    

Intervention name(s): High frequency extra thoracic oscillations vest; Intrathoracic oscillatory quake
Intervention type(s): Device; Device
Intervention description(s): Oscillations applied extra thoracic through vest device aiming for airway clearance; Oscillation introduced intrathoracic through quake device through placing quake in mouth and ordering patient to breathing to move secretions
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Community Acquired Bacterial Pneumonia (CABP)
Condition: Infections; Community Acquired Pneumonia
MeSH terms: Pneumonia; Pneumonia, Bacterial
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      This is a study of safety and effectiveness of ceftaroline fosamil in children with Community
      Acquired Bacterial Pneumonia receiving antibiotic therapy in the hospital.
    

Detailed description: 
      To evaluate safety, effectiveness, pharmacokinetics and tolerance of ceftaroline fosamil in
      children who are initially hospitalized with Community Acquired Bacterial Pneumonia (CABP)
    

Intervention name(s): Ceftaroline fosamil; Ceftriaxone; amoxicillin clavulanate
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Treatment Group 1:
Drug: Ceftaroline fosamil Children ≥ 6 months: IV ceftaroline fosamil 12 mg/kg for subjects weighing ≤ 33 kg or 400 mg for subjects weighing > 33 kg will be infused over 60 (± 10) minutes every 8 hours (q8h) (± 1 hour)
Children < 6 months: Ceftaroline fosamil 8 mg/kg over 60 (± 10) minutes q8h (± 1 hour); Treatment group 2:
75 mg/kg/day up to 4 g/day IV in equally divided doses, each infused over 30 (± 10) minutes q12hr (± 2 hours); Oral Switch for Treatment Groups 1 and 2:
PO amoxicillin clavulanate 90 mg/kg/day divided q12h in subjects with infections due to susceptible organisms on or after Study Day 4 (a minimum of 7 IV doses required if randomized to ceftaroline.)
Other intervention name(s): Teflaro; PPI-0903; TAK-599; TAK599; PPI0903
Intervention MeSH terms: Amoxicillin; Ceftriaxone; Clavulanic Acid; Clavulanic Acids; Ceftaroline fosamil; Amoxicillin-Potassium Clavulanate Combination
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Infections; Pediatrics; Teflaro; cephalosporin