Developmental Phenomenology of Obsessive Compulsive Disorder and Tourette Syndrome in Children and Adolescents
Condition: Tourette Syndrome; Obsessive Compulsive Disorder
MeSH terms: Tourette Syndrome; Syndrome; Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Study type: Observational

Summary: 
      OBJECTIVES: I. Characterize the natural history, associated features, and severity of
      symptoms of obsessive compulsive disorder and Tourette syndrome in children and adolescents.

      II. Identify factors that influence the clinical course and prognosis of these patients.
    

Detailed description: 
      PROTOCOL OUTLINE: All patients and their families participate in 6 parts of the study:
      current severity of symptoms, coincident disease diagnoses, natural history, neuropsychologic
      assessment, physical and neurologic assessment, and family history and function. The
      evaluations include the following: Current Severity of Symptoms Assessment, Children's Yale
      Brown Obsessive Compulsive Scale (CY-BOCS), Clinician's Global Impression-Obsessive
      Compulsive Disorder (CGI-OC), Leyton Obsessional Inventory-Child Version (LOI-CV), Obsessive
      Compulsive Personality Rating Scale, Yale Global Tic Severity Scale(YGTSS), Clinician's
      Global Impression-Tourette Syndrome (CGI-TS), Tourette Syndrome Symptom List (TSSL),
      Clinician's Global Impression-Anxiety (CGI-A), Covi Anxiety Scale (CAS), Children's Manifest
      Anxiety Scale-Revised (CMAS-R), Social Anxiety Scale for Children-Revised, Fear Survey
      Schedule for Children-Revised, Louisville Fear Survey, Children's Depression Rating
      Scale-Revised (CDRS-R), Clinician's Global Impression-Depression (CGI-D), Children's
      Depression Inventory (CDI), The Dimensions of Temperament Survey (DOTS), Mosher Guilt
      Scale-Revised, Real vs. Ideal Self Questionnaire, Harter Self-Perception Profile For
      Children, The Children's Global Assessment Scale (CGAS), The Child Behavior Checklist (CBCL),
      Coincident Disease Diagnoses Assessment, Diagnostic Interview Schedule for Children-II
      (DISC-II), Yale Best Estimate of Diagnoses Schedule (Y-BEDS), Natural History Evaluation,
      Yale Natural History Questionnaire (YHNQ), Social Readjustment Scale for Children,
      Neuropsychologic Assessment, Delayed Response Tasks, Continuous Performance Task, Continuous
      Recognition Memory, Selective Reminding Procedures, Card Sorting Tasks, Wechsler Intelligence
      Scale for Children-Revised, Digit Span, Digit Symbol and Mazes Paced Auditory, Serial
      Addition Task, Purdue Pegboard Trail Making Tasks, Fluency Tasks, Rey-Osterreith Complex
      Figure Stanford-Binet Intelligence Scale-Fourth Edition, Physical, Neurologic, and
      Neurochemical Assessment Physical exam (abbreviated), Physical and Neurological Examination
      for Soft Signs (PANESS), 24-hour urinary cortisol and catecholamines, Family History and
      Family Function Assessment of family history, Assessment of Family Functioning.

      The estimated duration of study is 10 years.
    

Keywords: Tourette syndrome; anxiety disorder; disease-related problem/condition; neurologic and psychiatric disorders; obsessive compulsive disorder; oncologic disorders; rare disease