The Healthy Human Global Project - Hong Kong (HHGP-Hong Kong)
Condition: Healthy; Immune System and Related Disorders
Study type: Observational

Summary: 
      The Healthy Human Global Project-Hong Kong aims to elucidate the heritable and non-heritable
      factors that drive immunological variance within a healthy population in Hong Kong. By
      gaining a deeper understanding of these parameters, a path can be paved for personalised and
      precision medicine, tailored for an Asian population.
    

Detailed description: 
      The Healthy Human Global Project-Hong Kong (HHGP-Hong Kong) is built upon the Milieu
      Intérieur Consortium, a population-based study coordinated by the Institut Pasteur in Paris
      since 2011 (ClinicalTrials.gov study numbers NCT01699893 and NCT03905993). The Milieu
      Intérieur comprised of 1,000 healthy participants that are unrelated, and of Western European
      ancestry, to investigate inter-individual immunological variances by integrating intrinsic,
      environmental and genetic factors in innate immunity and adaptive immunity. Through the
      quantification of white blood cells by utilising standardised flow cytometry and correlating
      with sociodemographic variables, the Institut Pasteur team found that smoking, age, sex, and
      latent infection with cytomegalovirus, were the main non-genetic factors that affected
      variation in parameters of human immune cells.

      The HHGP-Hong Kong will, therefore, replicate and adapt from the study design of Milieu
      Intérieur recruiting 1,000 healthy participants, drawn from the FAMILY Cohort, to better
      understand the immunological variance within the Hong Kong population. This Cohort was part
      of a prospective population-based study in 2007, consisting of 46,001 participants in Hong
      Kong. It was the first large-scale programme to understand the determinants of physical,
      mental, and social wellbeing in Hong Kong.

      A technological platform will be developed to provide a personalized patient management
      strategy that takes into account individual genetics, previous infection history, resident
      microbiota, as well as personal lifestyle and environmental factors to define immune health.
    

Intervention name(s): No intervention
Intervention type(s): Other
Intervention description(s): No intervention
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        The HHGP- Hong Kong will recruit 1,000 healthy participants, drawn from the FAMILY Cohort,
        its affiliates, or Hong Kong residents, to better understand the immunological variance
        within the Hong Kong population. This Cohort was part of a prospective population-based
        study in 2007, consisting of 46,001 participants in Hong Kong. It was the first large-scale
        programme to understand the determinants of physical, mental, and social wellbeing in Hong
        Kong. The Cohort has an excellent (99.8%) coverage of the neighbourhoods in Hong Kong and
        represents roughly 1% of all households, which enables detailed studies linking the social
        environment to physical and mental health.
      
Biospecimen description: 
      Blood, nasopharyngeal, stool, and hair samples from healthy adult donors
    
Keywords: Community based cross-sectional study; Observational cohort