Repeatability of Blood Glucose Responses to Resistance Exercise in Type 1 Diabetes
Condition: Type 1 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Interventional

Summary: 
      This study proposes to examine the impact of time of day (morning versus afternoon) on the
      variability of blood glucose responses to high resistance exercise in a single group of
      patients with type 1 diabetes. Participants will be asked to wear a continuous glucose
      monitor during the 3 weeks of testing. During the six exercise sessions (three in the morning
      while fasted and three in the afternoon), participants will complete the same resistance
      exercise protocol.
    

Detailed description: 
      Pre-test measures: Interested participants will be invited to the Physical Activity and
      Diabetes Laboratory on the main campus of the University of Alberta. They will be asked
      questions related to their physical activity levels and medication, and blood pressure will
      be measured to assess their eligibility. Where participants are eligible, anthropometric
      characteristics will be measured using standard protocols, as will blood pressure. A blood
      sample will be drawn for assessment of HbA1c. Participants will be introduced to the weight
      lifting equipment and the proper lifting techniques associated with each exercise prior to
      performing a standardized test to determine the maximum weight they can safely lift eight
      times while maintaining proper form (8 repetition maximum - 8RM).

      Testing sessions: Participants will be asked to arrive at the lab either between 7 and 8 am
      in a fasting state, or between 4 pm and 5 pm. The three morning and three afternoon testing
      sessions will have identical exercise protocols. Participants will be asked to perform three
      sets of eight repetitions of seven different exercises (bench press leg press, shoulder
      press, leg curl, lat pulldown, abdominal crunches, seated row) at their pre-determined 8RM.
      Participants will be asked to match their food and insulin intake as closely as possible on
      testing days to avoid having these as confounders.

      A continuous glucose monitor (CGM) sensor will be subcutaneously inserted by one of the
      investigators (trained by a group from the CGM manufacturer) into the anterior abdominal area
      of the participant in the morning of the day prior to the first testing session. CGM will
      store glucose data every 5 minutes for up to 7 days. During this time, participants will be
      asked to wear an accelerometer to allow for the objective assessment of background physical
      activity and sleep quality. Along with this device, they will fill out an activity and sleep
      log to improve the analysis of the data.
    

Intervention name(s): Fasted morning resistance exercise; Afternoon resistance exercise
Intervention type(s): Behavioral; Behavioral
Intervention description(s): On three separate occasions, participants will perform a standardized resistance exercise protocol in the morning while fasting.; On three separate occasions participants will perform a standardized resistance exercise protocol in the afternoon after eating their regular lunch
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other