Egg Effects on Atherogenic Dyslipidemias, Glucose Metabolism and Inflammation in Diabetic Subjects
Condition: Diabetes Mellitus; Inflammation
MeSH terms: Dyslipidemias; Inflammation
Study type: Interventional

Summary: 
      There is concern in the literature regarding egg consumption in diabetic people. The
      investigators hypothesis is that compared to an oatmeal-based breakfast, an egg-based
      breakfast will not increase the risk for heart disease in diabetic people but it may reduce
      inflammation, in this population characterized by chronic low grade inflammation.

      This is a cross-over study in which subjects will be randomly allocated to consume 1 egg per
      day for breakfast or a bowl of oatmeal with lactose-free milk for 5 weeks. After a 3 wk
      washout period, subjects will be allocated to the alternate treatment for additional 5 weeks.

      Blood will be collected at baseline and at the end of each dietary period to measure plasma
      lipids, glucose, insulin, glycosylated hemoglobin and inflammatory markers.
    

Detailed description: 
      This study is conducted in diabetic patients who are given two distinct breakfasts: eggs and
      oatmeal in a crossover design. The investigators hypothesis is that eggs will not increase
      the risk for heart disease in this population when compared to oatmeal but they will more
      likely reduce inflammation due to the presence of the carotenoids, lutein and zeaxanthin that
      are highly available in eggs.

      In this study, the investigators are evaluating three main things

        -  Atherogenic dyslipidemia by measuring plasma lipids and lipoprotein mean size and
           subfractions by nuclear magnetic resonance.

        -  Glucose metabolism by measuring plasma glucose, insulin, insulin resistance and
           glycosylated hemoglobin.

        -  Inflammation by measuring liver enzymes, C reactive protein, tumor necrosis
           factor-alpha, interleukin-6.

      All these measurements were done 24 weeks after completion of the study All data will be
      presented 1 year after completion of the study
    

Intervention name(s): Egg, one a day, for breakfast; Oatmeal, one cup a day
Intervention type(s): Other; Other
Intervention description(s): One egg per day as breakfast for 5 weeks followed by a 3 week washout period and 5 additional weeks on oatmeal. This is a randomized crossover design. Half of subjects started with the eggs and the other half with oatmeal. Blood lipids, glucose and inflammatory measurements will be finished 24. weeks after completion of the study. Data will be reported 1 year after the completion of the study.; Subjects will be fed oatmeal for a period of 5 weeks. After 3 weeks they will be switched to the alternate diet. This is a randomized control trail in which plasma glucose, plasma lipids and inflammatory markers will be measured. All these measurements will be finished 24 weeks after completion of the study. Data will be reported after 1 year of the completion of the study.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: egg; oatmeal; atherogenic dyslipidemia; glycosylated hemoglobin; inflammatory markers