bioihbjkbjnl/mcl2 huggingface dataset:
Effect of Muscular Exercise on Cough Reflex
Condition: Cough
MeSH terms: Cough
Study type: Interventional

Summary: 
      The hypothesis is that the cough reflex induced by capsaicin is inhibited during exercise.
      The purpose of this study is to determine if a short muscular exercise inhibits the cough
      reflex induced by capsaicin inhalation.
    

Detailed description: 
      Cough is an important reflex of defense of airways. It is also one of the more frequent
      symptoms during respiratory diseases. Chronic cough can be a disabling condition, apparently
      idiopathic or associated to pathology such as asthma, sinusitis with posterior discharge or
      gastroesophageal reflux.

      Factors susceptible to provoke or increase cough are well known, but inhibiting factors are
      much less known. Muscular exercise is thought to influence respiratory reflexes in a
      considerable and complicated way. For example, a bronchodilation is observed in healthy or
      asthmatic individuals, but recovery period frequently triggers asthma attacks. Effects of
      exercise on cough reflex are much less known.

      This study aims to determine the influence of muscular exercise on cough reflex in children
      and healthy adults.

      Highlighting the inhibition of cough reflex by exercise can have a significant effect on
      chronic cough patient care. There is actually no symptomatic treatment really effective
      without side effects.
    

Intervention name(s): Exercise; Capsaicin; Normal saline
Intervention type(s): Behavioral; Drug; Drug
Intervention description(s): 6 min running on a motor-driven tredmill in a climate room (18-20°C, humidity <10 mg/l). Tredmill speed and slope are adjusted to increase heart rate to about 80 % of maximum value predicted for age (= 210 - age in years) during the first 2-3 min and pursued until the end of exercise (3-4 min). Heart rate is measured during the whole exercise.; A compressed air-driven nebuliser is controlled by a dosimeter and a valve is used to deliver similar inspiratory flows for 400 msec in children and 1200 msec in adults.; A compressed air-driven nebuliser is controlled by a dosimeter and a valve is used to deliver similar inspiratory flows for 400 msec in children and 1200 msec in adults.
Intervention MeSH terms: Capsaicin
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
In Vivo Biomechanical Analysis of the Practitioner's Motion During a Peripheral Venous Catheter Insertion
Condition: Healthy
Study type: Interventional

Summary: 
      The aim of this study is to analyze the palpation and perforation motion performed by the
      practitioner during the insertion of a catheter while measuring the loads applied on the skin
      and the veins.

      These experimental measures will be used for the design of a more realistic peripheral venous
      catheter insertion simulator in order to better prepare healthcare students for their first
      in vivo venous puncture.
    


Intervention name(s): insertion of a catheter
Intervention type(s): Procedure
Intervention description(s): Analysis the palpation and perforation motion performed by the practitioner during the insertion of a catheter while measuring the loads applied on the skin and the veins
Allocation: Non-Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: catheter insertion; puncture; skin; vein; palpation; motion tracking
Effects of Home-based Physical Activity in Saudi Arabian Type-2 Diabetes Mellitus Patients.
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      The World Health Organization ranks Saudi Arabia as having the 7th highest rate of type-2
      diabetes in the world. This therefore makes diabetes the most challenging health problem
      facing Saudi Arabia. Importantly, physical activity has been shown to improve disease
      symptoms and overall health in patients with type-2 diabetes. However, findings relating to
      the prevalence of physical inactivity in the Saudi population confirm that a sedentary
      lifestyle is on the rise, within physical inactivity levels in adults being 80.5%. Therefore,
      interventions aimed at reducing physical inactivity using bespoke modalities pertinent to
      Saudi Arabia are clearly warranted.

      The purpose of this research project is to undertake a feasibility randomised control trial,
      examining the effects of a 12-week home-based physical activity programme on HbA1c, blood
      lipids, fasting glucose and other indices of health-related quality of life in Saudi Arabian
      adults with type-2 diabetes.
    


Intervention name(s): Physical activity; Usual care
Intervention type(s): Behavioral; Other
Intervention description(s): Participants will be asked to perform resistance exercises 3-times a week on alternating days for 12 weeks. Exercises will be performed with a TheraBand and will include the squat, lunge, press-up, cross body reach, reverse fly, lateral raise, biceps curl, triceps extension, frontal raise and bridge. In addition to the resistance exercises, the participants will perform aerobic exercise. They will be asked to download a specific exercise app to record the number of steps on day 1 of the intervention and participants who do not possess the required phone technology will be provided with a pedometer. They then will be asked to add 2000 steps on to their daily steps; this amount will then become their daily step goal. Once they have reached this goal on 4 out of 5 days, they will be asked to increase their new step step goal by an extra 500 per day.; Usual care.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Safety and Efficacy of NT 201, Free of Complexing Proteins, in the Treatment of Glabellar Frown Lines
Condition: Healthy
Study type: Interventional
Phase: Phase 3

Summary: 
      NT 201 is a Botulinum toxin type A preparation free of complexing proteins. Injected into the
      muscle, NT 201 causes a reversible local relaxation of the injected muscle. Botulinum toxin
      type A is widely used for aesthetic treatment of mimic wrinkles. This study will investigate
      the safety and efficacy of NT 201 in the treatment of glabellar frown lines.
    


Intervention name(s): NT 201
Intervention type(s): Drug
Intervention description(s): A Botulinum neurotoxin type A, free of complexing proteins
Detailed described in study protocol
Intervention MeSH terms: incobotulinumtoxinA
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Treatment of glabellar frown lines
Significance of an Elimination and Provocation Diet in Patients With Chronic Urticaria
Condition: Urticaria; Angioedema
MeSH terms: Angioedema; Urticaria; Chronic Urticaria
Study type: Interventional

Summary: 
      Patients with chronic urticaria undertake a five week elimination diet (pseudoallergen free
      diet). The efficacy of the diet will be determined by symptom score, by the use of rescue
      medication (oral antihistamines and glucocorticosteroids) and by a Quality of Life
      Questionnaire on week 0 and week 5. All patients with sufficient response (regarding the
      urticaria score) enter a second dietary part over six weeks, whereas a provocation diet is
      carried out. Each diet week a choice of pseudoallergen rich food is added, sorted by the type
      of pseudoallergens (e.g. biogenic amines, organic acids, flavours, additives). This study is
      conducted to investigate if the provocation diet could be a new diagnostic intervention to
      elucidate clinical relevant pseudoallergens.
    

Detailed description: 
      Chronic urticaria is defined as a daily or almost daily spontaneous occurrence of wheals that
      cause itching and lasting for at least six weeks. If there is no indication of a possible
      eliciting agent and because approximately 70% of patients benefit from it, a
      low-pseudoallergen diet should be carried out for 5 weeks. Although the low-pseudoallergen
      diet is successful, no explanation of the underlying mechanisms exists. On DBPC oral
      provocation testing with known food additives, only a small amount of patients, who
      experienced remission after a low-pseudoallergen diet react with new wheals and/or
      angioedema. For this discrepancy, natural food ingredients and new food additives are
      included in the dietary diagnostic. The high amount of substances, which are administrated
      within oral provocation testing can not reflect a realistic diet situation. Often it is
      impossible to ingest corresponding amounts of foods to reach the same concentration such as
      the provocation amount. Recording change reactions between food ingredients and the
      individual metabolism of the patients, the "step by step" food provocation method reveals
      itself to be most effective. In addition, individual predilections, amounts and frequency of
      ingested foods, are taken into consideration.
    

Intervention name(s): elimination diet; provocation diet
Intervention type(s): Procedure; Procedure
Keywords: low pseudoallergen diet; elimination diet; provocation diet; oral provocation; natural food ingredients; food additives; flavours
A Study o Evaluate the Safety, Tolerability, and Immunogenicity of MVC-COV1901, CT-COV-21 Sub-study
Condition: Covid19 Vaccine
MeSH terms: COVID-19
Study type: Interventional
Phase: Phase 2

Summary: 
      This sub-study is a prospective open-label, single-center study to demonstrate comparability
      of different manufacturing scales.
    

Detailed description: 
      In this sub-study, approximately 400 adults participants who are generally healthy or with
      stable pre-existing health conditions aged ≥ 20 to < 65 years will be enrolled. The first 250
      participants enrolled in this sub-study will receive MVC-COV1901(Scale A) and the remains
      will receive MVC-COV1901(Scale B). Each participant will receive 2 doses of study
      intervention, administered 28 days apart via IM injection in the deltoid region, preferably
      of the nondominant arm, at Day 1 and Day 29. The study procedure and visit schedule refer to
      the main study protocol and will be the same as the study procedure for the Immunogenicity
      Subset.
    

Intervention name(s): MVC-COV1901(S protein with adjuvant)
Intervention type(s): Biological
Intervention description(s): Approximately 400 participants will receive 2 doses of MVC-COV1901(S-2P protein with adjuvant) at Day 1 and Day 29 via intramuscular (IM) injection in the deltoid region
Intervention MeSH terms: Somatomedin B
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Covid19 vaccine
Comparative Bioavailability Study of Human Chorionic Gonadotropin (hCG)-IBSA Versus a Marketed hCG Formulation
Condition: Infertility
MeSH terms: Infertility
Study type: Interventional
Phase: Phase 1

Summary: 
      In the present study, the rate and extent of hCG absorption will be compared between the two
      treatments in healthy women aged 20 to 45 years.
    


Intervention name(s): Human hCG 10'000 IU; Recombinant hCG 6'500 IU
Intervention type(s): Drug; Drug
Intervention description(s): A single dose of 10'000 IU of human hCG will be injected in 24 healthy subject volunteers.; A single dose of 6'500 IU recombinant hCG will be injected in 24 healthy subject volunteers.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effects of Prebiotics on Cognition and Health
Condition: Physiological Stress; Cognitive Change; Gastrointestinal Health
Study type: Interventional

Summary: 
      This research intervention aims to examine the effects of prebiotic consumption on changes in
      behavioral and biological measures of cognition and stress among adults.
    

Detailed description: 
      Evidence-based dietary strategies provide behavioral means benefiting physical and cognitive
      function. Pertinent to the proposed work, dietary intake has been recently shown to have the
      potential to directly influence the gut microbiota composition as well as brain function.
      Specifically, the consumption of prebiotics or fibers metabolized by gut bacteria may also
      play a role. These foods are readily available in the marketplace, however, their
      implications for physical and cognitive function are not clear. Accordingly, the proposed
      study aims to investigate effects of prebiotic beverage consumption on changes in behavioral
      and biological measures of cognition and stress among adults.
    

Intervention name(s): Lactose Free 1% Milk; Lactose Free 1% Milk + 10 g prebiotic
Intervention type(s): Other; Other
Intervention description(s): 8 oz of study beverage daily; 8 oz of study beverage supplemented with 5 grams of fructooligosaccharide and 5 grams of galactooligosaccharide
Other intervention name(s): Control
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Participants will pass through 2 arms, control and prebiotic, in a randomized, counterbalanced order.
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Awaken Prone Positioning Ventinlation in COVID-19 Patients
Condition: COVID-19
MeSH terms: COVID-19
Study type: Interventional

Summary: 
      Awaken prone positioning (APP) ventilation has been widely accepted as a standard regimen in
      the management of COVID-19 patients. Physiological studies have proved ventilation/perfusion
      improvement during APP in COVID-19, which was associated improved oxygenation. However, the
      optimal duration for APP was not yet demonstrated. In this study, we aimed at the prolonged
      APP to see whether this could improve patients outcomes.
    


Intervention name(s): Awaken prone positioning ventilation
Intervention type(s): Procedure
Intervention description(s): patients were mandated to keep a prone position for at least 12 hours.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Measuring Mindfulness Application
Condition: Cognitive Change
Study type: Interventional

Summary: 
      The purpose of the research study is to learn more about how ROTC cadets may engage with
      mindfulness training program content that is delivered through a smartphone or website
      application. Mindfulness training program content includes mindfulness practices that foster
      attention and awareness.
    


Intervention name(s): Mindfulness Training
Intervention type(s): Behavioral
Intervention description(s): The intervention includes four weeks of MT application use, accessed via phone or computer, consisting of 15-minute daily mindfulness practices 5 days a week.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Mindfulness Training; Cognitive Training; Psychological Health
A Comparison of the Analgesic Efficacy and Safety of Once Daily Tramadol OAD Tablets to Twice Daily Tramadol BID for the Treatment of Osteoarthritis of the Knee (Extension Protocol) and Open Label Safety Follow-Up
Condition: Pain; Osteoarthritis, Knee
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to evaluate the long-term safety (up to one year) of Tramadol
      Once-A-Day (OAD) tablets at the highest doses: 200-400 mg
    


Intervention name(s): Tramadol OAD; Tramadol OAD; Tramadol OAD; Tramadol OAD 100mg
Intervention type(s): Drug; Drug; Drug; Drug
Intervention MeSH terms: Tramadol
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Clinical Audit of Cardio Pulmonary Resuscitation Management in Adults Patient Units of Care by in Situ Simulation
Condition: in Hospital Cardiac Arrest; in Situ Simulation; Clinical Audit; Education
MeSH terms: Heart Arrest
Study type: Observational

Summary: 
      Clinical audit of in-hospital cardiac arrest management by in situ simulation

      Objectives: correct latent safety threats, knowledge gap, and crisis resource management
      (CRM)

      Design: clinical audit, observational sudy. Primary outcome: In Hospital resuscitation scale.
      Exploratory outcomes: non technical skills, validated stress inventory, and questionnaire on
      perceptions of the simulation and organisational changes needed.
    


Intervention name(s): cardio-pulmonary resuscitation
Intervention type(s): Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Team members
      
Keywords: in hospital cardiac arrest; in situ simulation; clinical audit; education
Symbiotic Yogurt, Calcium Absorption and Bone Health in Young Adult Women
Condition: Osteoporosis
MeSH terms: Osteoporosis
Study type: Interventional

Summary: 
      Prebiotics have been linked to increased calcium absorption in animal and human studies
      (particularly in adolescents and in premenopausal women). Similarly, probiotics have been
      found to benefit calcium homeostasis in pregnant women, and to promote bio-mineralization in
      animal models. The effect of symbiotic on calcium absorption has been tested in rats, but not
      in human studies. The primary objective of this study is to investigate the effect of daily
      consumption of a functional symbiotic yogurt containing inulin and Lactobacillus rhamnosus
      compared to a control yogurt, on calcium absorption in young adult women. A secondary
      objective is to relate changes in calcium absorption following yogurt consumption, with
      calcium metabolism, vitamin D status, bone mass, calcium intake and overall composition of
      habitual diet.
    

Detailed description: 
      A potential strategy to reduce the risk of osteoporosis later in life is to promote optimal
      bone mass during early adulthood by including in the diet functional foods that maximize the
      efficiency of calcium absorption. This approach is specially important in women because of
      their greater risk for osteoporosis than men. In this study, we hypothesized that the daily
      consumption of a yogurt containing inulin and Lactobacillus rhamnosus (symbiotic yogurt)
      increases the efficiency of calcium absorption in young adult women when compared to daily
      consumption of a yogurt of similar composition but without prebiotic or probiotic (control
      yogurt). Subjects in this study will be randomly assigned to consume daily the symbiotic
      yogurt or the control yogurt during two 3-week periods with a wash-out period of 3-weeks, in
      a cross-over design. Calcium absorption will be measured by stable calcium isotope
      methodology. Bone mass (BMD, BMC) will be measured by dual-Y ray absorptiometry. Serum intact
      parathyroid hormone, 25-hydroxyvitamin D and dietary intake will be measured by conventional
      methods.
    

Intervention name(s): yogurt
Intervention type(s): Dietary Supplement
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: 3 weeks on symbiotic yogurt or control yogurt, with a 3 week wash out period in between. Type of yougurt consumed first is randomized.
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: functional foods; dairy foods; calcium absorption; prebiotics and probiotics; young women; bone health
Ultrasonic Weaning Criteria in Prolonged Ventilation
Condition: Acute Respiratory Distress Syndrome
MeSH terms: Respiratory Distress Syndrome; Respiratory Distress Syndrome, Newborn; Acute Lung Injury; Syndrome
Study type: Observational

Summary: 
      compare and evaluate the effect of use of ultrasonic criteria of weaning versus the
      conventional ways of weaning in post-traumatic acute respiratory distress syndrome (ARDS)
      patients who were ventilated for a long time. And compare their effect on the duration of ICU
      stay.
    

Detailed description: 
      It is a prospective double blind study done on total 200 patients. Who were weaned from
      ventilator after being ventilated for > one week due to respiratory failure. This respiratory
      failure was selected in our study to be from severe lung contusion and post-traumatic acute
      respiratory distress syndrome. Patients were randomly allocated in one of two groups each
      group contain 100 patients. Group A considered control group. Those patients weaned from the
      ventilator by the conventional criteria of weaning. While group B weaned from the ventilator
      by the ultrasound criteria of weaning. All patients weaned from both groups followed for six
      days for signs of failure of weaning ,signs of post-extubation respiratory failure. And
      number of patients who were re-ventilated and who discharged from ICU in both groups recorded
      and compared.
    

Intervention name(s): clinical weaning criteria
Intervention type(s): Diagnostic Test
Intervention description(s): Xray chest and calculation of thr rapid shallow breathing rate
Other intervention name(s): arterial blood gases and reading on the ventilator
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        It is a prospective double blind study done on total 200 patients. Who were weaned from
        ventilator after being ventilated for > one week due to respiratory failure. This
        respiratory failure was selected in our study to be from severe lung contusion and
        post-traumatic acute respiratory distress syndrome.