bioihbjkbjnl/mcl2 huggingface dataset:
Effect of Myofascial Release Technique In Patients With Unilateral Cervical Radiculopathy
Condition: Cervical Radiculopathy; Cervical Radicular Pain; Cervical; Hernia; Cervical Disc Disease; Cervical Disc Herniation; Pain
MeSH terms: Intervertebral Disc Displacement; Radiculopathy; Hernia
Study type: Interventional

Summary: 
      The aim of the study is to investigate the effectiveness of myofascial release technique on
      pain, range of motion, muscle strength, functionality and quality of life in individuals
      diagnosed with cervical radiculopathy with unilateral arm involvement and compare this with
      exercise. The individuals included in the study will be randomized into two groups, 17
      control and 17 study groups. Sessions will be 3 days a week for 4 weeks. Conventional
      physiotherapy and exercise program will be applied to the control group, conventional
      physiotherapy and myofascial release technique will be applied in the intervention group.
      Conventional physiotherapy methods; It will include Transcutaneous Electrical Nerve
      Stimulation (TENS), Ultrasound (US), hotpack agents. Exercise program; extension, right and
      left lateral flexion, right and left rotation exercises, chin-tuck, right and left upper
      trapezius muscle group stretching, neck extensor muscle group isometric strengthening
      exercises. Myofascial release will be applied to the fingers, wrist flexor-extensor muscle
      groups, elbow flexor-extensor muscle groups, pectoral muscles and rotator cuff muscle groups.
      Patients will be evaluated before and after treatment with Visual Analogue Scale (VAS),
      Goniometric measurements, algometer, myometer, Neck Disability Scale, "Disability of Arm,
      Shoulder and Hand" Questionnaire (DASH).
    


Intervention name(s): Myofascial Release Technique; Exercise
Intervention type(s): Other; Other
Intervention description(s): Myofascial release focuses on reducing pain by easing the tension and tightness in the trigger points. Therapist will gently massage the myofascia and feel for stiff or tightened areas. Normal myofascia should feel pliable and elastic. The therapist will begin massaging and stretching the areas that feel rigid with light manual pressure. The therapist then aids the tissue and supportive sheath in releasing pressure and tightness. The process is repeated multiple times on the same trigger point and on other trigger points until the therapist feels the tension is fully released.; Exercise is recommended by physical therapists for most cervical radiculopathy patients.
In this study, a customized exercise program will be applied for patients with cervical radiculopathy.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Cervical Radiculopathy; Pain; Radiculopathy; Cervical; Hernia; Myofascial Release; Exercise
Evaluating the Safety and Immune Response to Two Doses of a Dengue Virus Vaccine Administered 12 Months Apart
Condition: Dengue
MeSH terms: Dengue
Study type: Interventional
Phase: Phase 1

Summary: 
      Dengue viruses can cause dengue fever and other more severe forms of disease. This study will
      evaluate the safety and immune response to two doses of a dengue virus vaccine given 12
      months apart in healthy adults.
    

Detailed description: 
      Dengue viruses are a major health concern, particularly in the tropical and subtropical
      regions of the world. The World Health Organization (WHO) has made the development of a
      dengue vaccine a top priority. There are four types of dengue viruses (DEN1, DEN2, DEN3, and
      DEN4), each of which can cause various illnesses, including dengue fever, or the more severe
      disease, dengue hemorrhagic fever/shock syndrome (DHF/DSS). This study will evaluate the
      safety and immune response to two doses of a dengue virus vaccine (TV003) when administered
      12 months apart in healthy adults. The study will also evaluate whether the candidate vaccine
      may protect against all four types of dengue viruses.

      Participants will be randomly assigned to receive the TV003 study vaccine or placebo vaccine.
      At study entry, participants will undergo a blood collection and physical examination, and
      female participants will take a pregnancy test. Participants will then receive an injection
      of their assigned vaccine. They will take their temperature three times a day for 16 days
      after each vaccination and record the results on a diary card, which research staff will
      review during participants' study visits. Additional study visits will occur on Days 3, 10,
      14, 21, 28, 56, 90, 180, 270, and 330. All study visits will include blood collection and a
      physical examination; select visits will include a pregnancy test for female participants. At
      a study visit on Day 360, all participants will receive an injection of the same vaccine they
      received at study entry. Additional study visits will occur on Days 363, 370, 374, 381, 388,
      416, 450, and 540, and will include the same study procedures as previously performed.
    

Intervention name(s): TV003 Vaccine; Placebo Vaccine
Intervention type(s): Biological; Biological
Intervention description(s): TV003 will contain an admixture of the following monovalent dengue vaccines: 10^3 PFU of rDEN1Δ30, 10^3 PFU of rDEN2/4Δ30(ME), 10^3 PFU of rDEN3Δ30/31-7164, and 10^3 PFU of rDEN4Δ30. TV003 vaccine will be administered by subcutaneous injection in participants' deltoid region of the upper arm.; Placebo vaccine will be administered by subcutaneous injection in participants' deltoid region of the upper arm.
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Effect of Flavonoids on Gut Permeability in Cyclists
Condition: Gut Permeability, Gut Inflammation
MeSH terms: Inflammation
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this investigation is to test the hypothesis that chronic supplementation with
      a dairy-based beverage containing a mixture of blueberry, green tea, and cocoa flavonoids
      (non-nutritive natural plant compounds) will ameliorate exercise-related changes in gut
      permeability and inflammation. In a previous feeding study in humans, (NCT02728570) a high
      flavonoid diet (flavonoids at 340 mg/1000kcal) was effective in mitigating gut permeability
      and inflammation in overweight and obese adults compared to a low flavonoid diet (10mg/1000
      kcal). To test this hypothesis, 20 trained cyclists will complete a randomized crossover
      study with supplementation for 2 weeks with a dairy-based sports beverage containing either a
      high flavonoid (approximately 620 mg) or low flavonoid (approximately 5mg) beverage. After
      the two week intervention, cyclists will complete a 1 hour cycling trial (45 min at 65% VO2
      max then 15 minute time trial). The primary endpoints will be gut permeability as measured by
      plasma intestinal fatty acid binding protein (I-FABP) and the differential sugar test.
      Secondary endpoints will include gut inflammation (measured via fecal calprotectin), plasma
      cytokines (IL-6, IL-10 and TNFα) and plasma LPS. In addition, the distance completed in the
      time trial is a secondary endpoint.
    


Intervention name(s): Low flavonoid beverage; High flavonoid beverage
Intervention type(s): Drug; Drug
Intervention description(s): A low flavonoid, sports nutrition recovery beverage will be prepared from milk (78%), sugar (8.6%), maltodextrin (8.6%), placebo blueberry powder (2.4%), alkalized cocoa powder (1.6%), and whey protein isolate (0.6%). The beverage will contain approximately 5mg flavonoids per serving.; A high flavonoid, sports nutrition recovery beverage will be prepared from milk (78%), sugar (8.6%), maltodextrin (8.6%), blueberry powder (2.4%), cocoa powder (1.6%), green tea extract (0.1%) and whey protein isolate (0.6%). The beverage will contain approximately 620 mg flavonoids per serving.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Treatment of Follicular Lymphoma With High Dose Therapy and Stem Cell Support Followed by Rituximab and Alpha Interferon
Condition: Follicular Lymphoma
MeSH terms: Lymphoma; Lymphoma, Follicular
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a non-comparative, prospective, non-randomized single centre phase II clinical trial
      of Rituximab and alpha interferon immunotherapy following autologous stem cell transplant in
      patients with relapsed follicular lymphoma conducted at Toronto Sunnybrook Regional Cancer
      Centre/Sunnybrook and Women's Health Sciences Centre.
    


Intervention name(s): Rituximab; Alpha Interferon
Intervention type(s): Drug; Drug
Intervention MeSH terms: Interferons; Interferon-alpha; Interferon-alfa-1b; Rituximab
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
RCT of Automated Telephone Outreach to Improve Colorectal Cancer Screening
Condition: Colorectal Cancer
MeSH terms: Colorectal Neoplasms
Study type: Interventional

Summary: 
      This large randomized controlled trial is testing the effectiveness of automated telephone
      outreach with speech recognition to improve rates of screening for colorectal cancer. The
      hypothesis is that the intervention improves rates of screening overall and specifically
      rates of colonoscopy.
    

Detailed description: 
      Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in the United
      States. Despite widespread dissemination of evidence-based guidelines recommending CRC
      screening, a large proportion of eligible individuals do not undergo screening. A variety of
      interventions have been tested to increase screening in primary care, but there remains an
      urgent imperative to develop and evaluate cost-effective and widely applicable approaches to
      promoting screening. In March 2005, Harvard Pilgrim Health Care, a large non-profit HMO in
      New England, carried out an internally funded program to increase CRC screening. The HMO
      randomized 80,000 members aged 50 to 64 years to receive automated telephone outreach with
      speech recognition or usual care. The intervention entailed the telephone engagement of
      members in a dialogue with a computer-programmed, responsive human voice about the importance
      of CRC screening, the options for undergoing screening, and encouragement to follow-up with
      their primary care physicians. The present study involves a 12-month follow-up of all
      eligible members randomized to intervention or usual care in March 2005, with assessment of
      the effect of the intervention on rates of CRC screening. This study has important
      implications for increasing CRC screening. With health plans expanding efforts to screen
      large populations for CRC and other malignancies, automated telephone outreach with speech
      recognition can reach large numbers of individuals with educational and reminder messages. It
      is important to know whether these efforts to promote screening are effective in overcoming
      known disparities in screening for CRC. If proven effective and cost-effective, this
      technology has the potential for widespread adoption and population-wide improvements in CRC
      screening and other prevention-related behaviors, with the ultimate public health goal of
      reducing the burden of suffering attributable to cancer and its complications.
    

Intervention name(s): Automated Telephone Outreach with Speech Recognition
Intervention type(s): Behavioral
Intervention description(s): Automated Telephone Outreach with Speech Recognition calls to health plan members to promote screening
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Colon cancer; Prevention; Screening; Telephone
Study to Evaluate the Effect of Benralizumab on Allergen-Induced Inflammation in Mild, Atopic Asthmatics
Condition: Asthma
MeSH terms: Inflammation
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a randomized, double-blind, parallel group, placebo-controlled study designed to
      evaluate the effect of a fixed 30 mg dose of benralizumab administered subcutaneously every 4
      weeks on allergen-induced inflammation in subjects with mild atopic asthma challenged with an
      inhaled allergen.
    

Detailed description: 
      This randomized, double-blind, parallel group, placebo-controlled study will evaluate the
      effect of a fixed 30 mg dose of benralizumab administered subcutaneously every 4 weeks for 3
      doses on allergen-induced inflammation in subjects with mild atopic asthma challenged with an
      inhaled allergen.

      Approximately 38 non-smoking men and women (18 - 65 years of age) corticosteroid-free (oral
      and inhaled) mild, atopic asthmatics who have demonstrated a dual (early and late) asthmatic
      response to inhaled allergen challenge at screening will be recruited to complete the study.
    

Intervention name(s): Benralizumab; Placebo
Intervention type(s): Biological; Other
Intervention description(s): Benralizumab subcutaneously on study day 0 until study week 16 day 1 inclusive; Placebo subcutaneously on study week 0 until study week 16 day 1 inclusive
Intervention MeSH terms: Benralizumab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: asthma
Proximal Humerus Fractures: Randomized Study Between Locking Nails and Locking Plates for Neer 2 and 3 Parts
Condition: Humerus; Proximal Humeral Fracture; Fractures, Bone; Humeral Fractures; Wounds and Injuries; Arm Injuries
MeSH terms: Wounds and Injuries; Fractures, Bone; Humeral Fractures; Shoulder Fractures; Arm Injuries
Study type: Interventional

Summary: 
      The hypothesis of this study is to determine whether the technique of intramedullary locking
      nail presents clinical results comparable to the technique of locking plates, based on the
      Constant Score.
    


Intervention name(s): Locked plate; Intramedullary locked nail
Intervention type(s): Device; Device
Intervention description(s): Osteosynthesis with philos plate, through deltopectoral approach and rotator cuff augmentation with inabsorbable poliester suture; Intramedullary locked nail performed by antero-lateral transdeltoid minimally invasive approach and rotator cuff augmentation with inabsorbable poliester suture
Other intervention name(s): Philos plaste, Synthes, Switzerland; Centronail, Proximal Humeral Nail, Orthofix, Italy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Humerus; fracture; nail; plate; tuberosity
Seroepidemiological Study of SARS-CoV-2 (COVID-19) Infection in Population Subgroups in the State of São Paulo
Condition: COVID; SARS-CoV 2
MeSH terms: Infections
Study type: Observational

Summary: 
      Seroepidemiological Study of SARS-CoV-2 Infection in Population Subgroups in the State of São
      Paulo
    

Detailed description: 
      This is a cross-sectional study to estimate the prevalence of antibodies against SARS-CoV-2
      is different population subgroups in the State of São Paulo
    

Intervention name(s): Serological test; Nasopharyngeal Swab; Oropharyngeal Swab
Intervention type(s): Diagnostic Test; Diagnostic Test; Diagnostic Test
Intervention description(s): IgM and IgG for SARS-CoV-2; PCR for SARS-CoV-2; PCR for SARS-CoV-2
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        -  Home contacts of health professionals at the Hospital das Clínicas of the Medical
             School of USP diagnosed with COVID-19;

          -  Refugees living in the city of São Paulo - CORAS-BR Project;

          -  Blood Donors of the Fundação Pró-Sangue Hemocentro de São Paulo

          -  Butantan Penitentiary Progression Center participants;

          -  Penitentiary System Hospital Center (CHSP) participants;

          -  SABE Project - Cohort of the Elderly in the city of São Paulo and their home contacts;

          -  Residents of the Long Term Care Institution (ILPI) of Botucatu;

          -  Home contacts of children and adolescents with a positive diagnosis for COVID-19,
             attended at Instituto da Criança, HCFMUSP.
      
Biospecimen description: 
      Nasopharyngeal Swab, Oropharyngeal Swab and Blood Samples
St. John's Wort Vs. Placebo in Obsessive-Compulsive Disorder.
Condition: Obsessive Compulsive Disorder
MeSH terms: Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine the effectiveness of St. John's Wort as compared to
      placebo (an inactive substance) in the treatment of outpatients with obsessive compulsive
      disorder.
    

Detailed description: 
      The objective of the proposed study is to assess the efficacy of the herbal St. John's Wort
      (SJW) in the treatment of symptoms of obsessive-compulsive disorder (OCD). The approach is to
      conduct a 12-week, randomized, double blind, placebo controlled, parallel group pilot trial
      with 30 subjects in each of two arms. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) will
      be the primary measure for evaluating OCD. An intention-to-treat analysis will be done to
      compare the two arms.
    

Intervention name(s): St. John's Wort
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: obsessive compulsive disorder; ocd; Anxiety; St. John's Wort; Wisconsin; Psychiatric; Mental health
Safety and Efficacy Study of R932348 Ophthalmic Solution in Chronic Ocular Graft Versus Host Disease Patients(DROPS-2)
Condition: Chronic Graft-versus-host Disease
MeSH terms: Bronchiolitis Obliterans Syndrome; Keratoconjunctivitis; Keratoconjunctivitis Sicca; Graft vs Host Disease
Study type: Interventional
Phase: Phase 2

Summary: 
      -  To assess the efficacy of R348 Ophthalmic Solutions administered for 12 weeks to
           subjects evaluated by objective and subjective measures.

        -  To investigate the safety and tolerability of R348 Ophthalmic Solutions administered for
           12 weeks to subjects.
    


Intervention name(s): R348 Ophthalmic Solution, 0.2%; R348 Ophthalmic Solution, 0.5%; Placebo Ophthalmic Solution
Intervention type(s): Drug; Drug; Other
Intervention description(s): R348 Ophthalmic Solution 0.2% 2 drops per eye twice a day; R348 Ophthalmic Solution, 0.5% 2 drops per eye twice a day; Placebo Ophthalmic Solution 2 drops per eye twice a day
Other intervention name(s): R932348; R932348
Intervention MeSH terms: Pharmaceutical Solutions; Ophthalmic Solutions
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Chronic Graft versus Host Disease; Keratoconjunctivitis Sicca
Benefit of Complex Fractionated Atrial Electrograms Elimination in Atrial Fibrillation Ablation
Condition: Atrial Fibrillation; Catheter Ablation
MeSH terms: Atrial Fibrillation
Study type: Interventional
Phase: Phase 3

Summary: 
      The aim of this study is to evaluate whether performing complex fractionated atrial
      electrograms ablation improves outcomes in persistent or atrial fibrillation ablation.
    


Intervention name(s): Additional Complex Fractionated Electrograms ablation; Standard atrial fibrillation ablation procedure
Intervention type(s): Procedure; Procedure
Intervention description(s): Atrial fibrillation ablation with pulmonary vein ablation and roof line. In addition, complex fractionated atrial electrograms ablation will be performed, lasting at most 30 minutes.; Standard procedure for persistent atrial fibrillation including circumferential pulmonary vein ablation and roof line, both being tested. No other lines or lesions will be performed.
Other intervention name(s): Complex atrial fractionated electrograms ablation; ACVP ablation; Roof line
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Atrial fibrillation; Complex fractionated electrograms; CFAE
Innovative Treatments in Pneumonia (ITIP) 3
Condition: Pneumonia
MeSH terms: Pneumonia
Study type: Observational

Summary: 
      This is a prospective observational study assessing the clinical outcomes of children 2 to 59
      months of age with both pneumonia and other co-morbidities presenting to a tertiary hospital
      outpatient setting in Malawi, Africa who are most at risk for mortality or have other
      complications and thus, are typically excluded from childhood pneumonia studies.
    


Intervention name(s): oral amoxicillin or parenteral ampicillin/ penicillin and gentamicin; parenteral ampicillin/ penicillin; gentamicin
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: Amoxicillin; Gentamicins; Penicillins; Ampicillin
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Children 2 to 59 months of age who present to Kamuzu Central Hospital or Bwaila District
        Hospital with fast-breathing pneumonia or chest-indrawing pneumonia and other
        co-morbidities, or severe pneumonia AND are excluded from ITIP1 and ITIP2