bioihbjkbjnl/mcl2 huggingface dataset:
Intraoral Cryotherapy in Root Canal Retreatment
Condition: Cryotherapy Effect
MeSH terms: Periodontitis
Study type: Interventional

Summary: 
      The aim of this study was to evaluate the effect of intraoral cryotherapy application on
      postoperative pain in single and multiple visit retreatment of teeth with symptomatic or
      asymptomatic apical periodontitis. This clinical trial was also investigate the potential of
      intraoral cryotherapy application to reduce on postoperative analgesic use of patients in
      line with the results obtained.

      A total of 118 patients who met the inclusion criteria were selected for the study. The
      patients were randomly divided into two groups as single visit and multiple visit (n=59).
      Then, each group was randomly divided into three subgroups as control (without cryotherapy),
      15 minutes of cryotherapy, and 30 minutes of cryotherapy. Twenty two teeth were retreated in
      each cryotherapy group and 15 teeth in each control group. Visual analogue scale (VAS) was
      used to evaluate and compare postoperative pain. Postoperative analgesic use of patients was
      also recorded.
    


Intervention name(s): intraoral ice pack application
Intervention type(s): Procedure
Intervention description(s): Tap water was filled into plastic ice molds and kept in the freezer in the clinic until the application was made. The ice packs used were weighed with digital pocket scale (Knmaster CT1000, Turkey) as 6-8 grams. In the cryotherapy groups, at the end of the first appointment ice packs were removed from the freezer, wrapped in sterile gauze and placed on the vestibular mucosa of the teeth.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: analgesic; cryotherapy; periapical periodontitis; postoperative pain; retreatment
Ultrasound Guided Costotransverse Block for Breast Cancer Surgery
Condition: Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      Costotransverse block is a novel regional anesthesia technique described a few months ago.
      It's use for breast surgery has been reported by only one case report in the literature. As
      the investigators have considered that Costotransverse block can be efficacious for providing
      postoperative analgesia in the breast surgeries, the investigators have implemented the
      application of this blockade into practice at the clinic. The main purpose of this study is
      to evaluate the analgesic effect of ultrasound-guided unilateral costotransverse block in
      breast cancer surgery.
    


Intervention name(s): costotransverse block
Intervention type(s): Other
Intervention description(s): patient controlled analgesia devices with tramadol
Other intervention name(s): patient controlled analgesia
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: ultrasound guided block
Effects of Caffeine on Intermittent Hypoxia in Infants Born Preterm
Condition: Hypoxia
MeSH terms: Hypoxia
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this pilot study is to document the extent to which intermittent hypoxia
      persists beyond the age of discontinuing clinical methylxanthine, and will assess the effect
      of caffeine treatment on the number of intermittent hypoxia episodes and the total number of
      seconds with a hemoglobin oxygen saturation (HbO2 SAT) below 90%.
    

Detailed description: 
      Infants with prior clinical treatment with caffeine in the neonatal intensive care unit
      (NICU) will be enrolled and continuous physiologic data recording of oxygen hemoglobin
      saturation (HbO2 SAT) and heart rate will begin as early as 33 weeks postmenstrual age (PMA).
      Randomization will occur when enrolled infants reach a corrected gestational age of at least
      34 weeks PMA AND clinical caffeine has been discontinued for at least 5 days. Infants will be
      randomized to receive caffeine or to continue with usual care. The group randomized to start
      caffeine will receive an oral loading dose of caffeine citrate of 20 mg/kg on Day #1,
      followed by a single daily oral maintenance dose of 6 mg/kg starting on Day #2 and continued
      daily thereafter until 40 weeks PMA. The continuous oximeter recordings will be stopped at
      the same time. The number of intermittent hypoxia events/hour per week will be compared
      between the caffeine group and the usual care (no-caffeine) group for each week of
      physiologic data recordings.
    

Intervention name(s): Caffeine citrate 6 mg/kg/day
Intervention type(s): Drug
Intervention description(s): Comparison of caffeine citrate 6 mg/kg/day versus no caffeine (usual care) on extent of intermittent hypoxia at 35, 36, 37, 38, 39, and 40 weeks postmenstrual age.
Other intervention name(s): Cafcit
Intervention MeSH terms: Caffeine; Caffeine citrate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Prematurity; Apnea of prematurity; Intermittent hypoxia
Pioglitazone Versus Metformin as First Treatment in Infertile Women With Polycystic Ovary Syndrome
Condition: Pioglitazone
MeSH terms: Polycystic Ovary Syndrome
Study type: Interventional
Phase: Early Phase 1

Summary: 
      Participants with PCOS will be divided into two groups then each group will randomly recieve
      one of the following treatment

        1. metformin will be adminstered in adose of 500 mg 3 times daily for 3 months to group B.

        2. pioglitazone will be administered in adose of 30 mg dialy for 3 months to group A.

        3. Induction of ovulation by clomiphene citate 50 mg tablets to all participants
    

Detailed description: 
      Participants with PCOS will be divided into two groups then each group will randomly recieve
      one of the following treatment

        1. metformin will be adminstered in adose of 500 mg 3 times daily for 3 months to group B.

        2. pioglitazone will be administered in adose of 30 mg dialy for 3 months to group A.

        3. Induction of ovulation by clomiphene citate 50 mg tablets once or twice dialy 12hours
           apart starting from the 3rd day of menstrual cycle and continue for five days during
           treatment with insulin sensitizing agents to group A and B.

      Participants with oligomenorrhea will recieve two tablets of noreththisterone 5 mg tab every
      12 hours for 5 days to allow for withdrawal bleeding before start ovulation induction
    

Intervention name(s): Pioglitazone; Metformin; Clomiphene Citrate
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Insulin sensitizing agents; Insulin sensitizing agent; Induction drug
Other intervention name(s): Glustazon; Cidophage; Clomid
Intervention MeSH terms: Metformin; Pioglitazone; Clomiphene; Enclomiphene; Zuclomiphene
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Sub-occipital Muscle Inhibition in Tension Type Headache
Condition: Tension-Type Headache
MeSH terms: Tension-Type Headache; Headache
Study type: Interventional

Summary: 
      The main objective of this study is to determine the effects caused in neck movement, neck
      pain, headache in patients with tension type headache and cervicogenic headache after
      application of sub-occipital muscle inhibition technique associated with interferential
      electrotherapy.
    

Detailed description: 
      This study is based on the combined application of sub-occipital muscle inhibition technique
      associated with interferential electrotherapy improves symptoms in patients with tension type
      headache and cervicogenic headache.

      The purposes of this study are:

        -  Evaluate the effectiveness of treatment based on the combined application of
           sub-occipital muscle inhibition technique associated with interferential electrotherapy
           in patients with tension type headache.

        -  Evaluate the effects of treatment caused in upper cervical movement.

        -  Evaluate the effects of treatment caused in neck pain.

        -  Evaluate the effects of treatment caused in headache.
    

Intervention name(s): Suboccipital inhibition
Intervention type(s): Other
Intervention description(s): Experimental: Suboccipital inhibition
The intervention group will receive a session of 20 minutes (5 minutes for the patient's reception, 10 for treatment and the following 5 minutes for rest and hemodynamic stabilization), twice a week for 4 weeks. The intervention will consist of suboccipital muscle inhibition and interferential current on the occipital muscles.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Tension-Type Headache; Physical Therapy Modalities; Musculoskeletal Manipulations; Sub-occipital muscle inhibition technique
Yellow Versus White Study
Condition: Cataract
MeSH terms: Cataract
Study type: Interventional
Phase: Phase 4

Summary: 
      Blue-light-filtering IOLs are implanted increasingly often in cataract surgery. Several
      studies examined the effect of blue-light-filters on contrast and colour vision. However, the
      study outcomes were varying. The present study investigated the effect of a
      blue-light-filtering IOL on colour perception and contrast acuity using highly sensitive
      measurement methods.
    


Intervention name(s): cataract surgery (Hoya AF-1 [UY] YA-60BB); cataract surgery (Hoya AF-1 [UV] VA-60BB lens)
Intervention type(s): Procedure; Procedure
Intervention description(s): implantation of a yellow Hoya AF-1 (UY) YA-60BB intraocular lens; implantation of an uncoloured Hoya AF-1 (UV) VA-60BB
Other intervention name(s): Hoya AF-1 (UY) YA-60BB; Hoya AF-1 (UV) VA-60BB
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: intraocular lens; blue-light filtering intraocular lens; contrast acuity; color vision
Phase 3 Study of Deoxycholic Acid Injection (ATX-101) Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area
Condition: Moderate or Severe Submental Fullness
Study type: Interventional
Phase: Phase 3

Summary: 
      To evaluate the safety and efficacy of deoxycholic acid injection in the reduction of
      submental fat (fat below the chin).
    


Intervention name(s): Deoxycholic acid injection; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Formulated as an injectable solution containing deoxycholic acid at a concentration of 10 mg/mL.; Phosphate buffered saline placebo for injection
Other intervention name(s): ATX-101; Kybella
Intervention MeSH terms: Deoxycholic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Gum Acacia and Blood Glucose
Condition: Diet Modification
Study type: Interventional

Summary: 
      This study will provide needed insight on the satiety and blood glucose and l effects of the
      soluble fiber gum acacia at 20g and 40g doses.
    

Detailed description: 
      This is a randomized, single-blind, crossover, intervention study testing the satiety and
      blood glucose effects of the soluble fiber gum acacia.
    

Intervention name(s): Low Fiber; High Fiber; Placebo/Control
Intervention type(s): Other; Other; Other
Intervention description(s): 20 g of acacia gum will be added to orange juice; 40 g of acacia gum will be added to orange juice; No acacia gum will be added to orange juice.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: subjects will consume 0, and 2 doses of acacia gum
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Study to Assess the Safety, Pharmacokinetics/Dynamics of DS-1040b in Subjects With Acute Submassive Pulmonary Embolism
Condition: Pulmonary Embolism; Thrombotic Disease
MeSH terms: Pulmonary Embolism; Embolism
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This is a Phase 1b, double-blind (participants and Investigators), placebo-controlled,
      randomized, single-ascending dose, multi-center study to assess the safety, efficacy,
      tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of DS-1040b in participants
      with acute submassive pulmonary embolism.
    


Intervention name(s): DS-1040b; Placebo; Enoxaparin
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Single, continuous intravenous infusion over 12 to 24 hours (depending on cohort); Single, continuous intravenous infusion of 0.9% sodium chloride over 12 to 24 hours; Subcutaneous injection 1 mg/kg twice daily
Intervention MeSH terms: Enoxaparin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Venous thromboembolism (VTE); Pulmonary embolism (PE); Acute Submassive Pulmonary Embolism
Evaluation of Different Strategies of Pericardial Drainage After Aortic Valvular Surgery
Condition: Pericardial Effusion; Late Cardiac Tamponade; Surgical Reintervention
MeSH terms: Pericardial Effusion; Cardiac Tamponade
Study type: Interventional

Summary: 
      The incidence of pericardial effusion and late cardiac tamponade after aortic and valvular
      surgery is higher than after other cardiac surgical procedures. The aim of this study is to
      evaluate the clinical safety and efficacy of prolonged mediastinal drainage using small, soft
      silastic drains (Blake drain, Ethicon USA) versus conventional mediastinal drainage using
      large chest tubes. A prospective randomized trial.
    

Detailed description: 
      The incidence of pericardial effusion and late cardiac tamponade after aortic and valvular
      surgery is higher than after other cardiac surgical procedures. The aim of this study is to
      evaluate the clinical safety and efficacy of prolonged mediastinal drainage using small, soft
      silastic drains (Blake drain, Ethicon USA) versus conventional mediastinal drainage using
      large chest tubes. Patients undergoing aortic and / or valvular surgery will be randomized in
      two groups. In group A, mediastinal drainage will be accomplished using a 28F or 32F chest
      tube in the anterior mediastinum and a 19F Blake drain located in the posterior pericardial
      cavity. In group B, mediastinal drainage will be accomplished using two 28F or 32F chest
      tubes located in the anterior mediastinum. In both groups, conventional chest tubes will be
      removed on the first postoperative day, while patients in the group A will have prolonged
      drainage using the Blake drain until output is less than 50 ml over 24 hour. Patients will be
      followed during their postoperative course for occurrence of significant pericardial effusion
      as detected on routine echocardiogram and late cardiac tamponade requiring reintervention.
    

Intervention name(s): Blake Drains (Blake drain, Ethicon USA); Standard mediastinal drainage
Intervention type(s): Device; Device
Intervention description(s): 19F Blake drain located in the posterior pericardial cavity; Mediastinal drainage will be accomplished using 28F or 32F chest tube located in the anterior mediastinum
Other intervention name(s): Blake drain: prolonged mediastinal drainage; mediastinal drainage
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: late cardiac tamponade
Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients
Condition: Aggressive Periodontitis
MeSH terms: Periodontitis; Aggressive Periodontitis; Aggression
Study type: Observational

Summary: 
      The study was to intended to visualize the nuclear localization of vitamin D receptor in oral
      tissues of aggressive periodontitis patients to better understand the potential for receptor
      in disease activity or progression.
    

Detailed description: 
      Aggressive periodontitis (AgP) is an infectious disease of the periodontium which affects
      young adults, causing damage to the supporting apparatus of the teeth, leading to rapid bone
      resorption and tooth loss. Its clinical features have been shown to result from several
      genetic and environmental factors.

      This has increased the interest to research those genetic host factors as they may provide
      useful risk markers, reveal important information regarding the pathogenesis and also
      identification of effective preventive agents that might help decrease the disease burden.

      1,25-dihydroxyvitamin D3,apart from these traditional calcium-related actions, this active
      form is being increasingly recognized for its potent anti-proliferative, anti-differentiative
      and immunomodulatory activities.

      The calcitriol activity is largely mediated by the vitamin D receptor (VDR) whose expression
      has been described in some tissues. VDR is localized in both the cytosol and nucleus and
      accumulates in the nucleus in response to 1,25,dihydroxyvitamin D3 binding.

      Expression and nuclear activation of the VDR are necessary for the effects of vitamin D.
      Thus, alterations in the vitamin D pathway lead to disturbances in mineral metabolism. It may
      be hypothesized that the rapid bone loss which occurs in aggressive periodontitis patients
      may be due to decreased or absence of expression of Vitamin D receptor in the nucleus.
    

Intervention name(s): Vitamin D receptor
Intervention type(s): Genetic
Intervention description(s): 50-100mg gingival tissue samples were collected from both test and control group for immunohistochemical staining to assess the number of vitamin D receptors in nucleus as well cytoplasm and also for RNA isolation to check the presence of VDR gene.
Other intervention name(s): 1,25,dihydroxyvitamin D3 receptor
Intervention MeSH terms: Vitamin D; Dihydroxycholecalciferols
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        The study population was divided in to two groups i.e test and control group
LPN in Patients With High-complex Renal Tumors
Condition: Renal Cancer; Renal Neoplasm; Renal Cell Carcinoma; Surgery; Oncology; Kidney Ischemia; Kidney Injury; Urologic Neoplasms; Urologic Cancer; Kidney Neoplasms
MeSH terms: Neoplasms; Carcinoma, Renal Cell; Kidney Neoplasms; Urologic Neoplasms; Ischemia
Study type: Observational

Summary: 
      The study aims to investigate the rationale for LPN in patients with high-complexity renal
      tumors in terms of oncologic and functional outcomes.
    

Detailed description: 
      From November 2009 to October 2018, 399 patients underwent LPN and 307 patients to
      laparoscopic radical nephrectomy (LRN). 41 patients with RENAL score ≥ 10 enrolled in LPN and
      265 patients to the LRN group. Propensity score matching (matched by age, gender, clinical
      tumor stage, tumor size, baseline renal function, comorbidities such as diabetes mellitus
      (DM), hypertension (HT), coronary artery disease (CAD), and final tumor pathology of RCC) was
      used to reduce selection bias. Functional and oncological outcomes were compared between the
      two groups. After propensity score analysis, 39 patients in the LRN group were matched with
      39 in the LPN group.
    

Intervention name(s): laparoscopic partial nephrectomy; Laparoscopic radical nephrectomy
Intervention type(s): Procedure; Procedure
Intervention description(s): Nephron sparing minimally invasive surgery; Completely removal of kidney by using laparoscopic surgery
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        From November 2009 to October 2018, 399 patients underwent LPN and 307 patients to
        laparoscopic radical nephrectomy (LRN). 41 patients with RENAL score ≥ 10 enrolled in LPN
        and 265 patients to the LRN group. Propensity score matching (matched by age, gender,
        clinical tumor stage, tumor size, baseline renal function, comorbidities such as diabetes
        mellitus (DM), hypertension (HT), coronary artery disease (CAD) and final tumor pathology
        of RCC) was used to reduce selection bias. Functional and oncological outcomes were
        compared between the two groups. After propensity score analysis, 39 patients in the LRN
        group were matched with 39 in the LPN group.
      
Keywords: Laparoscopy; nephrometry score; partial nephrectomy; propensity score matching; radical nephrectomy
Three Different Oral Hygiene Regimes on Three Volatile Sulfur Compounds
Condition: Halitosis
MeSH terms: Halitosis
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of the study is to evaluate the effect of various oral hygiene regimes on three
      volatile sulfur compounds.
    

Detailed description: 
      Thirty male monk volunteers who matched with the including criteria were divided randomly
      into two groups. Both groups were practiced to brush their teeth with scrubbing method for
      one week. Then, each group were instructed to do different additional protocol regimen- group
      A have to do mouth washing and tooth brushing and group B have to practice tongue cleaning
      addition to tooth brushing for three weeks. At the fifth week, both groups were instructed to
      practice tooth brushing, mouth washing and tongue cleaning. Three different volatile sulfur
      compounds were measured by oral chroma. Tongue characteristics, oral examination were checked
      as the outcomes of this study.
    

Intervention name(s): chlorine dioxide; small toothbrush for tongue cleaning
Intervention type(s): Other; Other
Intervention description(s): First week, subjects were instructed to do regular tooth brushing. After that group A was requested to use chlorine dioxide mouthwash two time per days for three weeks in addition to tooth brushing and then, one week for combination of tooth brushing, tongue cleaning and mouth washing.; First week, subjects were instructed to do regular tooth brushing. After that group B was requested to brush their tongue with small toothbrush two time per days for three weeks in addition to tooth brushing and then, one week for combination of tooth brushing, tongue cleaning and mouth washing.
Intervention MeSH terms: Chlorine dioxide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Prevention
Buccal Versus Vaginal Misoprostol in Surgical Termination of the First Trimester Missed Abortion in Erbil
Condition: Missed Abortion
MeSH terms: Abortion, Missed
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine the effectiveness of buccal misoprostol and
      comparing this with vaginal route of the same drug.
    


Intervention name(s): Misoprostol (given buccally); Misoprostol (given vaginally)
Intervention type(s): Drug; Drug
Intervention description(s): 400 microgram misoprostol given buccally three hours before dilation and curettage (PHARMACIA CORPORATION - Istanbul, serial number 022-00, a tablet contains 200 micrograms); 400 microgram misoprostol (MISOPROSTOL - PHARMACIA CORPORATION - Istanbul, serial number 022-00, a tablet contains 200 micrograms)
Other intervention name(s): serial number 022-00; serial number 022-00
Intervention MeSH terms: Misoprostol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: First trimester missed abortion; Misoprostol; buccal; vaginal; cervical ripening; first trimester; missed abortion