Oxidative Status in Children With Autoimmune Thyroiditis
Condition: Autoimmune Thyroiditis
MeSH terms: Thyroiditis; Thyroiditis, Autoimmune; Hashimoto Disease
Study type: Observational [Patient Registry]

Summary: 
      Oxidative status in autoimmune thyroiditis was not investigated previously in children and
      adolescents. We investigated oxidant and antioxidant systems in a cohort of Egyptian children
      and adolescents with AIT to explore their relation with biomarkers of autoimmunity and
      thyroid function.
    

Detailed description: 
      Methods: A case control study included 32 children with autoimmune thyroiditis and 32 healthy
      subjects with matching age and sex were included as a control group. Thorough history,
      examination, thyroid ultrasound, measurement of thyroid-stimulating hormone (TSH) and free
      thyroxine (FT4), as well as anti-thyroid peroxidase antibodies (TPOAb) and anti-thyroglobulin
      antibody (TgAb) were done in addition to assessment of malondialdehyde (MDA) and total
      antioxidant capacity (TAC) levels as an oxidative stress markers. Results: Overt
      hypothyroidism was detected in 23/32 while subclinical hypothyroidism was detected in 9/32 of
      the studied patients. Malondialdehyde levels were significantly elevated while total
      antioxidant capacity levels were significantly decreased in autoimmune thyroiditis patients
      compared with healthy controls. The difference was more evident in patients with overt
      hypothyroidism than those with subclinical hypothyroidism. We also observed a significant
      positive correlation between anti-thyroid peroxidase antibodies levels and age, TSH,
      malondialdehyde, thyroid volume and a negative correlation with total antioxidant capacity
      and thyroxine .

      Conclusions: The high serum malondialdehyde and lower total antioxidant capacity levels in
      patients with autoimmune thyroiditis and the correlation of thyroid antibodies with
      biomarkers of oxidative stress may reflect the role of autoimmunity in the development of
      oxidative stress. Future studies are needed for evaluation of the antioxidant therapy for
      autoimmune thyroiditis patients.
    

Intervention name(s): measurement of oxidant status in AIT
Intervention type(s): Other
Intervention description(s): measurement of thyroid-stimulating hormone (TSH) and free thyroxin (FT4), as well as anti-thyroid peroxidase antibodies (TPOAb) and anti-thyroglobulin antibody (TgAb) were done in addition to assessment of malondialdehyde (MDA) and total antioxidant capacity (TAC) levels as an oxidative stress markers
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Our case control study was conducted on 32 children and adolescents with Autoimmune
        Thyroiditis attending the Pediatric Endocrinology Clinic of Assiut University Children
        Hospital, Assiut, Egypt. . Diagnosis of Autoimmune Thyroiditis had been made by elevated
        anti-thyroid peroxidase antibodies (TPO Ab) and/or anti-thyroglobulin antibodies (Tg Ab) as
        well as typical hypoechogenicity of the thyroid in high-resolution sonography . Another
        group of 32 age and sex-matched healthy subjects as a control group.
      
Keywords: Autoimmune Thyroiditis; Oxidative Status; Children