Efficacy and Safety Evaluating Study to Compare Kanarb (Fimasartan) and Cozaar® (Losartan) in Adult Patients With Grade I-II Arterial Hypertension
Condition: Arterial Hypertension
MeSH terms: Hypertension
Study type: Interventional
Phase: Phase 3

Summary: 
      Assess and compare the efficacy and safety of Kanarb (Fimasartan), manufactured by Boryung
      Pharmaceutical Co., Ltd, Republic of Korea, tablets 60/120 mg and Cozaar® (Losartan),
      manufactured by MERCK SHARP & DOHME B.V., Netherlands, tablet 50/100 mg in adult patients
      with Grade I-II arterial hypertension in 12 weeks of therapy
    

Detailed description: 
      1. To evaluate efficacy of 12-week Kanarb (Fimasartan), manufactured by Boryung
           Pharmaceutical Co., Ltd, Republic of Korea, tablets 60/120 mg and Cozaar® (Losartan),
           manufactured by MERCK SHARP & DOHME B.V., Netherlands, tablet 50/100 mg in adult
           patients with Grade I-II arterial hypertension.

        2. To evaluate safety of 12-week Kanarb (Fimasartan), manufactured by Boryung
           Pharmaceutical Co., Ltd, Republic of Korea, tablets 60/120 mg and Cozaar® (Losartan),
           manufactured by MERCK SHARP & DOHME B.V., Netherlands, tablet 50/100 mg in adult
           patients with Grade I-II arterial hypertension.

        3. Assess the pharmacokinetics parameters of Kanarb (Fimasartan), manufactured by Boryung
           Pharmaceutical Co., Ltd, Republic of Korea in adult patients with arterial hypertension
           I-II stage after a single dose.

      Starting dose of Kanarb (Fimasartan), manufactured by Boryung Pharmaceutical Co., Ltd,
      Republic of Korea is 60 mg, orally, once a day in the morning.

      The planned study duration for each subject is 18 weeks maximum:

      The screening period could takes up to 2 weeks (including the 1-week "wash-out" period ) -
      the screening period duration depends on the prior anti-hypertensive therapy:

        -  "naive" subjects who never received therapy (which must be reflected in the source
           documents), may be randomized after completion of all screening procedures;

        -  Subjects receiving anti-hypertensive therapy which may be discontinued without prior
           dose reduction must undergo a 7 days "wash-out" period, so the screening period will
           take at least 7 days;

        -  Subjects, receiving anti-hypertensive therapy which requires dose reduction before
           discontinuation must undergo the 7 days "wash-out" period after the last dose
           administration, so the screening period will consist of dose reduction period and a
           "wash-out" period.

      Treatment period - 12 weeks. Follow-up period - 4 weeks. The subjects will visit the clinical
      site every 4 weeks to measure ABP. The dose will be doubled in case if SBP ≥140 mmHg or DBP
      ≥90 mmHg at Visit 3 (Day 28) or at Visit 4 (Day 56).

      If necessary, the dose of the study drug may be increased based on the assessment of
      patient's condition performed at the phone contact (Day14±3). Patient may be called for an
      unscheduled visit for treatment adjustment (decided individually, with possibility of dose
      titration as per investigator's judgment, indicated in source documents).

      When possibilities are, the patient should be administrated by the study medication at the
      same time in the morning. Governing conditions for defining the time of the drug
      administration is the subject comfort and the time of its visits the research center.

      If laboratory tests are scheduled, a patient should come to the research center fasting (food
      is prohibited for 8 hours before the visit).

      All of the clinical evaluations are conducted on the next morning after taking the
      medication. On the visit day a patient comes to the research center not taking the drug, and
      after all the planned procedures are conducted the patient is administrated by the drug.
    

Intervention name(s): Fimasartan; Losartan
Intervention type(s): Drug; Drug
Intervention description(s): Starting dose of Kanarb (Fimasartan) is 60 mg, orally, once a day in the morning. The subjects will visit the clinical site every 4 weeks to measure Arterial blood pressure (ABP). The dose will be doubled in case if SBP ≥140 mmHg or DBP ≥90 mmHg at Visit 3 (Day 28) or at Visit 4 (Day 56).
If necessary, the dose of the study drug may be increased based on the assessment of patient's condition performed at the phone contact (Day14±3). Patient may be called for an unscheduled visit for treatment adjustment (decided individually, with possibility of dose titration as per investigator's judgment, indicated in source documents).
When possibilities are, the patient should be administrated by the study medication at the same time in the morning.; Cozaar® (Losartan), manufactured by MERCK SHARP & DOHME B.V., Netherlands, tablets 50/100 mg
Other intervention name(s): Kanarb; Cozaar®
Intervention MeSH terms: Losartan
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment