bioihbjkbjnl/mcl2 huggingface dataset:
Maximal Leg Press Strength Training Study for Coronary Artery Disease Patients
Condition: Heart Failure; Coronary Artery Disease
MeSH terms: Heart Failure; Coronary Artery Disease; Myocardial Ischemia; Coronary Disease
Study type: Interventional

Summary: 
      Maximal strength training has been shown to increase muscular strength, muscular volume and
      work economy. An 8 week maximal leg press training regime will be conducted on cardiac heart
      failure patients to evaluate whether they increase their maximal leg press strength, work
      economy, serum testosterone and quality of life. The study hypotheses are that:

        1. Aerobic work capacity will increase due to increased work economy, without increases in
           maximal oxygen uptake.

        2. Strength training will increase serum testosterone.
    


Intervention name(s): Strength training intervention
Intervention type(s): Behavioral
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Cardiac heart failure; Leg press; Maximal strength training; Serum testosterone; Work economy
Examination and Treatment of Pain in Front Foot
Condition: Pain
Study type: Observational

Summary: 
      Tibial flat foot deformity is the most common reason for metatarsalgia. Flat foot deformity
      is a sign of degenerated problems such as weakness in ligament or fractures. Furthermore,
      metatarsalgia can be a sign of excessive load caused by sport activities or at work. The
      condition is very common at diabetics and patients with rheumatism.

      The purpose of the study is to examine the load under the front foot at health people and
      patients with metatarsalgia. Furthermore, the researchers aim at being able to assess the
      best treatment of the flat foot deformity at each patient.
    


Sampling method: Non-Probability Sample
Study population: 
        Examination and treatment of pain in front foot
      
Keywords: Pain; Front foot; Flat foot; Metatarsalgia
Placental Membrane for Root Coverage
Condition: Gingival Recession
MeSH terms: Gingival Recession
Study type: Interventional

Summary: 
      Aim of the study was to evaluate the clinical efficacy of placental membrane with coronally
      advanced flap in covering single and multiple Miller's class I and II gingival recession
      defects.
    

Detailed description: 
      STUDY DESIGN A total number of 60 teeth in 15 subjects were selected. Patients with bilateral
      Miller's class I and II gingival recession defects in the maxillary or mandibular anterior
      and premolar region were selected and divided into two groups using a split mouth design.

      GroupI (Control) -30 recession defects treated with coronally advanced flap alone, using
      Zucchelli's technique.

      Group II (Test) - 30 recession defects treated with coronally advanced flap, using
      Zucchelli's technique along with placental membrane.

      .

      CLINICAL PARAMETERS:

        1. Probing Pocket Depth(PPD)

        2. Clinical Attachment Level(CAL)

        3. Height of Gingival Recession(HGR)

        4. Width of Gingival Recession(WGR)

        5. Width of Keratinized Gingiva(WKG) The clinical parameters were assessed & recorded on 0
           day, 90th day and 180th day
    

Intervention name(s): recession coverage; recession coverage and membrane
Intervention type(s): Procedure; Procedure
Intervention description(s): recession coverage done using Zuchellis technique; recession coverage done using Zuchellis technique with placental membrane
Other intervention name(s): root coverage technique; root coverage technique with membrane
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: gingival recession; Zuchellis technique,; placental membrane
ED-Home Pilot Study
Condition: Housing Problems; Drug Use; Alcohol; Use, Problem
MeSH terms: Alcohol Drinking
Study type: Interventional

Summary: 
      This is a single-arm pilot study to test the feasibility of homelessness prevention and
      substance use interventions to be delivered to at-risk patients in the Bellevue Hospital
      emergency department (ED). ED patients (n=40) found eligible for the study will complete a
      baseline assessment and receive referrals to appropriate services, with a final six-month
      follow-up assessment.
    

Detailed description: 
      ED patients found eligible for the study will complete a baseline survey and receive
      one-time, in person services at the time of the baseline/enrollment ED visit including
      referrals to homelessness prevention and substance use services, with a final six-month
      follow-up survey. Interim contacts at 7-10 days, 3 months, and 5 months will be used to
      assure intervention components were received and to confirm participant contact information.
    

Intervention name(s): Referral to homelessness prevention services; Substance use services; Follow-up
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Referral to Homebase homelessness prevention services offered by community-based organizations in NYC; Referral to substance use services (SBIRT and peer counselor/social work contact) available at Bellevue Hospital; Follow-up to assist participants in receiving homelessness prevention services
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Study To Evaluate The Safety And Efficacy Of The MyEllevate® Procedure
Condition: Soft Tissue Approximation; Elevation of Subdermis; Elevation of Underlying Muscle
Study type: Interventional

Summary: 
      The intended purpose of the MyEllevate® procedure used in this study is to assess the safety
      and efficacy of the procedure for soft tissue approximation and elevation of sub dermis and
      underlying muscle of the submentum & jawline.
    

Detailed description: 
      Subjects are to be enrolled in this clinical study if they are a healthy male or female
      between the age of 18 - 65. Up to 10 subjects will be enrolled at 2 study centers. All
      subjects will attend a screening/pre-procedure visit which may be performed on the same day
      as the procedure visit but no more than 30 days prior to their procedure.
    

Intervention name(s): MyEllevate Procedure
Intervention type(s): Device
Intervention description(s): The defined study area will be identified and may be marked with a surgical marker.
A local tumescent anesthetic, such as lidocaine, will be injected to the area prior to the procedure. The MyEllevate® device will be used in accordance with the Instructions for Use (IFU) manual for soft tissue approximation and elevation of sub dermis and underlying muscle of the submentum and jawline.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Dabigatran in an Interaction Probe Drug Cocktail
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      Four periods of oral dosing following overnight fasting (1. known metabolic probe drug
      cocktail consisting of caffeine, diclofenac, esomeprazole, metoprolol, midazolam; 2.
      dabigatran + cocktail; 3. dabigatran alone; 4. clarithromycin 3 days + cocktail +
      dabigatran). Blood samples collected for pharmacokinetics over 24 h. Washout between periods.
      Adverse events, haematology and clinical chemistry recorded.
    


Intervention name(s): Caffeine; Diclofenac; Esomeprazole; Metoprolol; Midazolam; Dabigatran; Clarithromycin
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): probe; probe; probe; probe; probe; probe; perpetrator
Intervention MeSH terms: Clarithromycin; Diclofenac; Metoprolol; Midazolam; Caffeine; Esomeprazole; Dabigatran
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Effects of Tai Chi Chuan in Patients After Recent Acute Myocardial Infarction
Condition: Acute Myocardial Infarction
MeSH terms: Myocardial Infarction; Infarction
Study type: Interventional

Summary: 
      This is a randomized Clinical Trial to assess the effects of Tai Chi Chuan on blood pressure,
      respiratory muscle strength and functional capacity in patients after recent acute myocardial
      infarction.
    

Detailed description: 
      Background:Patients with a recent myocardial infarction (MI) present a reduction in
      functional capacity expressed as a decrease in peak oxygen consumption (VO2 peak). The impact
      of a Tai Chi Chuan (TCC) cardiac rehabilitation program for patients recovering from recent
      MI has yet to be assessed. Our goal is to evaluate functional capacity after a TCC-based
      cardiac rehabilitation program in patients with recent MI.

      Methods: A single-blind randomized clinical trial was conducted. The researchers who
      performed the tests were blinded to group allocation. Between the 14th and 21st days after
      hospital discharge, all patients performed a cardiopulmonary exercise testing and a
      laboratory blood workup. Mean age was similar (56 ± 9 years in the TCC group and 60 ± 9 years
      in the control group). Patients allocated to the intervention group performed 3 weekly
      sessions of TCC Beijin style for 12 weeks (n = 31). The control group participated in 3
      weekly sessions of full-body stretching exercises (n = 30).
    

Intervention name(s): Tai Chi Chuan exercise; stretching exercise
Intervention type(s): Other; Other
Intervention description(s): patients in this group held three weekly classes of 60 minutes during 12 weeks of Tai Chi Chuan, Yang style. The exercises will be mild to moderate (HR 60 to 75% of HR Max). Slow movements combined with exercises and maintained using your own body weight.; patients in this group held weekly classes of two stretching for 12 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Yoga in Patients With Fibrosing Interstitial Lung Diseases
Condition: Fibrosing Interstitial Lung Diseases; Idiopathic Pulmonary Fibrosis
MeSH terms: Lung Diseases; Pulmonary Fibrosis; Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Fibrosis
Study type: Interventional

Summary: 
      Fibrosing interstitial lung diseases are characterized by loss of lung function, which leads
      to a decrease in quality of life and physical capacity. Several studies have shown an
      increase in quality of life and physical capacity after increasing physical activity in
      patients. There is evicence that yoga has a positive influence in patients with chronic
      obstructive pulmonary diseases, but so far, studies examining the effect of yoga in patients
      with fibrosing interstitial lung diseases are missing.

      Study aims are to determine the feasibilty of this study, and to determine the effects of
      yoga to patients' quality of life and physical capacity.

      Twenty patients with a fibrosing interstitial lung disease will be recruited and randomly
      assigned to the intervention or control group. Several questionnaires regarding quality of
      life will be conducted. Furthermore, the 6 minutes walking test, a lung function test and a
      biomarker analysis will be conducted at baseline and follow-up. The intervention group will
      participate in a 12 week yoga class, whereas the controll group will not participate. Yoga
      classes will be offered to the control group after the study.

      In addition, focus group interviews will be conducted at baseline and follow-up with the
      intervention group.
    

Detailed description: 
      Patients with a fibrosing interstitial lung disease will be recruited. In total 20 patients
      will be recruited, 10 for the intervention group and 10 for the control group.

      The Intervention group will participate in a 12 week yoga class with classes twice a week for
      about 1 hour. The control group will not participate in a yoga class.

      At baseline all patients will conduct a 6 minutes walking test, a lung function test, several
      surveys to measure health related quaility of life (King's Brief Interstitial Lung Disease
      Questionnaire (K-BILD), Hospital Anxiety and Depression Scale (HADS), Interstitial Lung
      Disease Anxiety questionnaire), and some blood will be drawn for biomarker analysis.

      Furthermore, participants in the Intervention group will participate in two focus group
      interviews, one at baseline and the second one at 12 week follow-up.
    

Intervention name(s): 12 week yoga class
Intervention type(s): Other
Intervention description(s): Intervention is a 12 week yoga class with classes twice a week. Each yoga class will last about 1 hour. Furthermore, focus group interviews will be conducted after the first and last yoga class.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: fibrosing interstitial lung disease; Idiopathic Pulmonary Fibrosis; Yoga
Evaluation of Incisors' Position Following Anterior Segment Retraction
Condition: Bimaxillary Protrusion
Study type: Interventional

Summary: 
      There's scarcity in literature concerning the issue of anterior segment retraction technique
      and its effect on anterior teeth position. Therefore, a randomized clinical trial has been
      chosen to investigate this issue, aiming to support clinicians with the best guidelines for
      anterior segment retraction.
    

Detailed description: 
      Thirty females with bimaxillary protrusion were randomly allocated into two groups. In one
      group, anterior segment retraction was commenced using an elastomeric chain rendering 160
      g/side extending between mini-screw implant and a hook crimped on 0.017- by 0.025-inch
      stainless steel wire distal to the lateral incisor. In the other group, anterior segment
      retraction was done using closing T-loops fabricated from 0.017- by 0.025-inch titanium
      molybdenum alloy (TMA) wire rendering comparable retraction force. Three-dimensional analysis
      of incisors' buccolingual (BL)- torque, mesiodistal (MD)- tip, vertical position changes and
      root resorption were assessed using cone beam computed tomography scans.
    

Intervention name(s): Power chain used for anterior segment retraction; T-loop fabricated to perform anterior segment retraction
Intervention type(s): Other; Other
Intervention description(s): Elastomeric chain rendering 160 g/side extending between mini-screw implant and a hook crimped on 0.017- by 0.025-inch stainless steel wire distal to the lateral incisor.; In the frictionless group, anterior segment retraction was done using closing T-loops fabricated from 0.017- by 0.025-inch titanium molybdenum alloy (TMA) wire rendering comparable retraction force.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Other
Keywords: friction; frictionless; CBCT; anterior segment retraction; T loop
Safety and Efficacy of Insulin Aspart in Children With Type 1 Diabetes
Condition: Diabetes; Diabetes Mellitus, Type 1
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Interventional
Phase: Phase 4

Summary: 
      This trial is conducted in Europe. The aim of this trial is to evaluate safety and efficacy
      in children with type 1 diabetes.
    


Intervention name(s): insulin aspart; human insulin; isophane human insulin
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Injected s.c. (under the skin) three times a day; Injected s.c. (under the skin) 30 minutes before the meals; May be administered s.c. (under the skin) in both treatment groups thrice daily
Intervention MeSH terms: Insulin; Insulin, Globin Zinc; Insulin Aspart; Isophane Insulin, Human; Insulin, Isophane; Isophane insulin, beef
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Study of Fluoxetine in Autism
Condition: Autistic Disorder
MeSH terms: Autistic Disorder
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to assess the effect of fluoxetine orally dissolving tablets
      (ODT) on the repetitive behaviors core domain in children and adolescents with Autistic
      Disorder. The study will also investigate the effect of fluoxetine on the improvement of
      symptoms and the effects on daily living of the patient's family.
    


Intervention name(s): Fluoxetine; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Once daily oral dispersible tablet 2mg 9mg or 18mg; Oral dispersible tablet placebo
Other intervention name(s): NPL-2008
Intervention MeSH terms: Fluoxetine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Autism; children; adolescent; Fluoxetine; Autistic Disorder; Repetitive behavior; SSRI; Selective Serotonin Reuptake Inhibitor
The Utility of Serum Tryptase in the Diagnosis of Shrimp- Induced Anaphylaxis
Condition: Food (Shrimp) Allergy
MeSH terms: Anaphylaxis
Study type: Interventional

Summary: 
      The purpose of this study was to investigate the utility of serum tryptase for the
      confirmation of shrimp-induced anaphylaxis.
    

Detailed description: 
      The diagnosis of anaphylaxis is based primarily on the clinical history. In some
      circumstances, inability to confirm the clinical diagnosis such as present with unusual
      manifestation, or when skin signs are absent likely contributes to underrecognition and
      undertreatment of the disease.

      Currently, products of mast cell activation (histamine and total tryptase) can be measure in
      clinical laboratories as markers of acute anaphylaxis events, however these tests have
      clinically relevant limitations.

      Therefore, development of laboratory tests with improved sensitivity and specificity that
      will support the clinical diagnosis of anaphylaxis are needed.

      In addition, shrimp is the major cause of seafood anaphylaxis among Thai children.
    

Intervention name(s): shrimp challenge
Intervention type(s): Procedure
Intervention description(s): Patients with history of shrimp allergy and positive skin tests to shrimp were recruited for shrimp challenges After shrimp challenges, patients with anaphylaxis defined as anaphylaxis group, patients with mild reactions defined as mild reaction group, and patients without symptom defined as control group
Other intervention name(s): open food challenge
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: tryptases; anaphylaxis; shrimp allergy
Osteoarthritis in Terms of ICF Components
Condition: Osteoarthritis; Quality of Life; OUTCOME MEASURES
MeSH terms: Osteoarthritis
Study type: Observational [Patient Registry]

Summary: 
      Osteoarthritis (OA) is a common degenerative disease associated with functional impairments,
      activity limitations, participation restrictions, as well as poor quality life. Therefore,
      the comprehensive assessment is important to determine how complex problems affect patients
      with OA. The first aim of this study was to link and allocate items of The Western Ontario
      and McMaster Universities (WOMAC) OA index with ICF Comprehensive Core Set for
      osteoarthritis. The second aim was to examine the relationship between the quality of life
      and each ICF component's scores determined based on clinical data of WOMAC in OA.
    


Intervention name(s): Evaluation
Intervention type(s): Other
Intervention description(s): health status and quality of life were evaluated
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Eighty-seven patients with OA were included in this study, who met inclusion criteria and
        were diagnosed with OA by the same rheumatologist according to the American College of
        Rheumatology Clinical Classification Criteria for OA.
Study to Determine the Bioavailability, Pharmacodynamic Effects, and Safety of Whole and Crushed ALO-01 Compared to Morphine Sulfate Immediate Release (MSIR)
Condition: Healthy
MeSH terms: Crush Injuries
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The purpose of the study is to determine the relative pharmacodynamic effects and safety of
      crushed and whole ALO-01 compared to MSIR and to Placebo, and of crushed ALO-01 to whole
      ALO-01; to determine the relative bioavailability of plasma morphine from crushed and whole
      ALO-01 compared to MSIR, and from crushed ALO-01 to whole ALO-01; and to determine the
      relative bioavailability of plasma naltrexone and 6-β-naltrexol from crushed ALO-01 to whole
      ALO-01.
    


Intervention name(s): ALO-01; MSIR; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): ALO-01 capsules; immediate release morphine sulfate; Placebo
Other intervention name(s): Morphine sulfate extended-release with sequestered naltrexone hydrochloride capsules
Intervention MeSH terms: Naltrexone; Morphine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: ALO-01; morphine; Determination of the relative pharmacodynamic effects; (including drug-liking), pharmacokinetics, and safety of; ALO-01 when administered whole or crushed and compared to; equivalent doses of immediate release morphine and placebo