bioihbjkbjnl/mcl2 huggingface dataset:
Hemodynamic Effects of Physiotherapy in the Early Postoperative Period
Condition: Physiotherapy; Postoperative; Lung Diseases
MeSH terms: Lung Diseases
Study type: Interventional

Summary: 
      Physiotherapy will be applied to the patients who undergo thoracotomy operation after 24
      hours of intensive care stay. Physiotherapy program includes breathing exercises, incentive
      spirometer training, ambulation. Oxygen saturation, heart rate and blood pressure values will
      be recorded before and after the training session. Changes in the follow-up parameters will
      be discussed.
    


Intervention name(s): physiotherapy
Intervention type(s): Other
Intervention description(s): Physiotherapy program includes breathing exercises, incisive spirometer study, grade ambulation. Oxygen saturation, heart rate and blood pressure values will be recorded before and after the session. Changes in the follow-up parameters will be discussed.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Screening
Nitroglycerin Prevents Radial Artery Occlusion
Condition: Injury of Radial Artery
MeSH terms: Arterial Occlusive Diseases
Study type: Interventional

Summary: 
      Trans-radial approach (TRA) has becoming popular and widely adopted over the last decade.
      However, radial artery occlusion (RAO) continues to be one of the limitation of trans-radial
      access and potentially limits the radial artery as an access site in the future. Several
      strategies have been used to decrease the incidence of RAO including the use of
      anticoagulation, maintenance of patency during hemostasis, or shortening the duration of
      compression. Currently, there is no data whether vasoactive pharmacological therapy such as
      nitroglycerin administered intra-arterially at the end of the procedure may reduce the
      incidence of RAO. It is hypothesized that the addition of nitroglycerin (nitric oxide donor)
      at the end of a TRA procedure may reduce the incidence of RAO.
    


Intervention name(s): 500 microgram of Nitroglycerin; Saline 5 mL
Intervention type(s): Drug; Drug
Intervention description(s): 500 microgram of Nitroglycerin (in 5 mL saline) given intra-arterially through the sheath at the end of transradial procedure; Saline 5 mL given intra-arterially through the sheath at the end of transradial procedure
Other intervention name(s): NTG; NaCl 0,9% 5mL
Intervention MeSH terms: Nitroglycerin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Prevention
Keywords: Nitroglycerin; Radial Artery Occlusion; Transradial Catheterization
Titanium-Sapphire Laser Trabeculoplasty in Glaucoma: A Randomized Study Comparing Titanium-Sapphire With Argon Laser Trabeculoplasty in Open-Angle Glaucoma Patients
Condition: Glaucoma, Open-Angle
MeSH terms: Glaucoma; Glaucoma, Open-Angle
Study type: Interventional

Summary: 
      Titanium Sapphire laser trabeculoplasty is effective in lowering intraocular pressure in
      glaucoma patients, and is comparable to argon laser trabeculoplasty
    

Detailed description: 
      Objective: To compare the medium-term outcome of Titanium-Sapphire laser trabeculoplasty
      (TiSLT) vs. Argon Laser Trabeculoplasty (ALT) in uncontrolled Open-angle Glaucoma (OAG)
      patients.

      Methods: Prospective, masked, randomized comparative clinical study. Thirty-seven OAG
      patients with uncontrolled IOP and no previous filtration surgery (22 females and 15 males,
      mean age of 68 years) participated. Eighteen were treated with TiSLT and 19 with ALT. All
      patients underwent a comprehensive eye examination including visual acuity, IOP, goniocscopy
      and slit-lamp biomicroscopy and visual field examinations. Patients were examined
      pre-operatively and then at 1 hour, 1 day, 1 week, 1, 3 and 6 months, 1 year and 18 months
      post-operatively.

      Main outcome measures: Final IOP, delta IOP and number of anti-glaucoma medications.

      Results: The 18 patients in the TiSLT arm had an average of 8.3(±2.7) mm Hg or 32% reduction
      from pre-operative IOP (P<0.001). The 19 patients in the ALT arm had a mean IOP decrease of
      6.5 (±4.3) mm Hg (P<0.001) or a 25% IOP reduction. Patients in both groups achieved a similar
      decrease in IOP (P>0.05). TiSLT patients had statistically significant fewer IOP spikes
      compared to the ALT group. (P=0.002). Two patients (1 in each arm) underwent trabeculectomy
      and were considered failures. Mean follow-up time was 15 months.

      Conclusions: TiSLT provides similar efficacy to ALT in IOP reduction in OAG patients, and may
      offer better safety with fewer IOP spikes see post-operatively.

      Application to clinical practice: If confirmed in additional studies, TiSLT may be used as an
      alternative to ALT in OAG patients.
    

Intervention name(s): Titanium Sapphire laser trabeculoplasty
Intervention type(s): Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Keywords: laser trabeculoplasty, glaucoma, argon, titanium-sapphire; IOP lowering effect; Adverse effects; IOP spikes
Safety/Efficacy Study: OPA-6566 Ophthalmic Solution in Subjects With Primary Open-Angle Glaucoma or Ocular Hypertension
Condition: Primary Open-angle Glaucoma; Ocular Hypertension
MeSH terms: Glaucoma; Glaucoma, Open-Angle; Ocular Hypertension; Hypertension
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This is a study of the safety, tolerability, pharmacokinetics (measurement of drug levels in
      the blood), and intraocular pressure lowering effects of OPA-6566 ophthalmic solution in
      subjects with primary open-angle glaucoma or ocular hypertension.
    


Intervention name(s): OPA-6566; Placebo; Latanoprost
Intervention type(s): Drug; Drug; Drug
Intervention description(s): OPA-6566, 2 dosing schedules (one drop once per day for 2 weeks and twice per day for 2 weeks); Placebo, 2 dosing schedules (one drop once per day for 2 weeks and twice per day for 2 weeks); Latanoprost (one drop once per day for 4 weeks)
Intervention MeSH terms: Latanoprost
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: open-angle glaucoma; glaucoma; ocular hypertension; intraocular pressure
Explore the Clinical Application Value of Ciprofol in Painless Colonoscopy
Condition: Induction of Anaesthesia
Study type: Interventional

Summary: 
      This study used propofol as a positive control, and adopted a large-sample, multi-center,
      randomized, double-blind, positive parallel controlled trial design to explore the clinical
      application value of ciprofol in painless colonoscopy.
    

Detailed description: 
      Subjects were randomly assigned 1:1 to receive intravenous ciprofol or propofol 1 hour prior
      to diagnosis and treatment. A centralized random grouping method was used in this study.
      After screening subjects, the researchers in each test center will log in to the random
      system after being confirmed by the researchers of the center, fill in the screening
      information, obtain the random number information, and issue the corresponding study drugs
      according to the random number. Random shelter number was generated by SAS software, and was
      used as the total blind base pair drug number and imported into the centralized random
      grouping system. In this study, evaluation researchers and drug administration researchers
      were set up. The whole process of the experiment was blind not only to the subjects, but also
      to the evaluation researchers. Evaluation investigators and administration investigators were
      set up in this study. The administration investigators were only involved in the process of
      random grouping, drug dispensing and administration, and the other processes including
      informed consent of subjects, screening, evaluation of efficacy indicators and safety, and
      planned visits were all completed by the evaluation investigators.
    

Intervention name(s): Propofol; Ciprofol
Intervention type(s): Drug; Drug
Intervention description(s): All patients completed pre-anaesthesia assessment, signed informed consent, and completed vital signs on the day before surgery, with values as baseline vital signs. On the day of surgery, after routine preparation before colonoscopy (fasting for at least 6h and water restriction for at least 2h before surgery), venous access was established in the left hand. 0.5μg/kg fentanyl was administered intravenously after oxygen inhalation through a nasal catheter (4-6 L/min). About 3 minutes after fentanyl administration, sedation induction was performed with ciprofol or propofol immediately.; Ciprofol
Intervention MeSH terms: Propofol
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants were randomly assigned 1:1 to receive intravenous ciprofol or propofol 1 hour before the start of treatment.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Propofol; Ciprofol
Experimental Headache Induced by Vasoactive Intestinal Polypeptide
Condition: Healthy Volunteers, Headache, Migraine, Hemodynamics, VIP, SPECT, Ultrasound
MeSH terms: Migraine Disorders; Headache
Study type: Interventional

Summary: 
      We hypothesized that infusion of VIP may induce headache in healthy subjects and that VIP
      induced headache may be associated with dilatation of intra- and extracerebral blood vessels.
      To test this hypothesis, we performed a double blind placebo controlled crossover study in
      normal human volunteers and studied the effect on headache and cerebral as well as
      hemodynamic parameters.
    

Detailed description: 
      We hypothesized that infusion of VIP may induce headache in healthy subjects and that VIP
      induced headache may be associated with dilatation of intra- and extracerebral blood vessels.
      To test this hypothesis, we performed a double blind placebo controlled crossover study in
      normal human volunteers and studied the effect on headache and cerebral as well as
      hemodynamic parameters. In a double-blind, placebo-controlled, crossover design, the subjects
      were randomly allocated to receive 8 pmol/kg/min VIP or placebo (isotonic saline) over 25
      min. Headache intensity, Mean velocity of blood flow in the middle cerebral artery
      (VmeanMCA), superfical temporal artery diameter, PetCO2, adverse events and vital signs were
      recorded at T-10, T0 and then every 10 min until 120 min after start of infusion. Single
      photon emission computerized tomography (SPECT) was performed at T-0, T20 and T60.
    

Intervention name(s): VIP
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double
Primary purpose: Diagnostic
Keywords: healthy volunteers, headache, migraine, hemodynamics, VIP, SPECT, ultrasound
Laser Therapy on Neuromuscular Performance
Condition: Fatigue
MeSH terms: Fatigue
Study type: Interventional

Summary: 
      Objective: Investigating the immediate effects of Low Level Laser Therapy (LLLT) on
      neuromuscular performance in healthy subjects after an induced muscle fatigue protocol.
      Methods: Eighty volunteers of both genders aged between 18 and 28 years underwent a
      preliminary evaluation using surface electromyography and isokinetic dynamometer of the
      flexor muscles of the elbow. The subjects were randomly allocated into 4 groups: G1 was
      control group; G2 placebo; G3 laser applied before fatigue protocol; and G4 immediately
      after. Muscular fatigue protocol consisted of 30 maximal concentric isokinetic contractions
      at 120°/s of the elbow flexor muscles. An 808 nm equipment was used for applying laser
      therapy, with a power of 100 mW and total energy of 20 J. Volunteers were reassessed after
      interventions.
    


Intervention name(s): Low Level Laser Therapy; Placebo Laser
Intervention type(s): Device; Device
Intervention description(s): Low Level Laser Therapy was applied at four points to the dominant upper limb of the volunteers on the muscle belly of the biceps. Delineation was done using a measuring tape from the elbow joint line to the acromion marked at points corresponding to 20%, 30%, 40% and 50% of this distance, focusing the application on the muscle belly region, thereby excluding the tendinous region.
An 808 nm equipment was used for applying laser therapy, with a power of 100 mW and total energy of 20 J.; Laser application simulation with a second pen of the laser device, which was disconnected and did not effectively irradiate energy.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Yoga@Work Intervention to Reduce Work-related Stress Among Information Technology Workers
Condition: Occupational Stress; Psychological Stress
MeSH terms: Occupational Stress; Stress, Psychological
Study type: Interventional

Summary: 
      Over the last several decades, occupational stress at workplace comprise a major burden.
      Office based work are more prone to sedentary lifestyle, postural issues, workplace stress,
      repetitive strain injury, poor employee health. Workplace wellness programs has been very
      feasible access to employees at their own convenience and need. Yoga@Work Program was
      developed to suit the need for information technology workers.
    


Intervention name(s): Yoga
Intervention type(s): Other
Intervention description(s): Each yoga session included warm-up practices (for the large joints, spine, and extremities), Simple postures (Asana), breathing exercises (pranayama) and meditation/relaxation. All the yoga participants were given handouts to practice everyday at work as its feasible
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Comparison of Esomeprazole to Aerosolized, Swallowed Fluticasone for Eosinophilic Esophagitis
Condition: Esophagitis
MeSH terms: Esophagitis; Eosinophilic Esophagitis
Study type: Interventional
Phase: Phase 2

Summary: 
      Eosinophilic esophagitis (EE) is a recently recognized entity. It has been thought to be
      related to both allergies and acid reflux. There have been reports that both swallowed,
      aerosolized steroids and proton pump inhibitors have been effective treatments. The
      researchers propose to directly compare the efficacy of aerosolized fluticasone to
      esomeprazole in the treatment of eosinophilic esophagitis. The hypothesis is that aerosolized
      fluticasone (Flovent) will be more effective in relieving symptoms of EE than esomeprazole
      (Nexium) treatment. Patients will undergo endoscopy, pH monitoring and manometry for
      diagnosis. Following diagnosis of EE by pathology (biopsy of esophagus), patients will be
      randomized to esomeprazole or swallowed fluticasone for 8 weeks. At the end of 8 weeks,
      subjects will be asked to repeat upper endoscopy with biopsies. Three questionnaires
      (dysphagia, gastroesophageal reflux disease [GERD], and allergy) will be completed by the
      patient at the first endoscopy and at the end endoscopy. The primary objective is to measure
      change in eosinophil infiltration of the esophagus in response to treatment of allergy
      (swallowed fluticasone) versus treatment for reflux (esomeprazole) in EE patients.
    

Detailed description: 
      This is a randomized, non-blinded, multicenter treatment trial to demonstrate and compare the
      efficacy of esomeprazole and fluticasone in the treatment of eosinophilic esophagitis.

      Following the initial diagnostic EGD with four quadrant biopsy, serum eosinophil count and
      serum IgE levels will be measured. Patients will undergo 24 hour pH study to determine the
      incidence of reflux in this population. Clinical assessment will be performed with validated
      questionnaires quantifying dysphagia, GERD, and allergy/atopy. Patients will be randomized to
      8 weeks of either esomeprazole versus swallowed aerosolized fluticasone. After 8 weeks of
      therapy, upper endoscopy will again be performed. Eosinophils per high power field will be
      quantified, and biopsies will be stained for major basic protein. Dysphagia, GERD, and
      allergy/atopy questionnaires will be repeated, as will serum eosinophil counts and IgE
      measurements.
    

Intervention name(s): esomeprazole; fluticasone
Intervention type(s): Drug; Drug
Intervention description(s): esomeprazole dosed qam for 8 weeks; fluticasone dosed 220 mcg 2 puffs swallowed BID for 8 weeks
Other intervention name(s): Nexium; Flovent
Intervention MeSH terms: Fluticasone; Esomeprazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Eosinophilic esophagitis; esomeprazole; fluticasone
Compliance Feasibility Study for Remote Phase 2 Cardiac Rehabilitation
Condition: Referred by Cardiologist for Phase 2 Cardiac Rehabilitation
Study type: Interventional

Summary: 
      This study evaluates the compliance of patients in a Phase 2 (outpatient clinic based)
      cardiac rehabilitation program, who are offered the opportunity to perform the rehab remotely
      (e.g. at home, not at the clinic), using a remote monitor and smart-phone application.
    

Detailed description: 
      In spite of the fact that cardiac rehabilitation has been shown to be beneficial to patients
      who have had a cardiac event, such as a heart attack, only 5% of eligible patients complete
      this program. Some of the reasons cited include limited facility access, travel time and
      cost.

      We are testing the hypothesis that cardiac rehab compliance will be greater if patients are
      offered the opportunity, and associated technology, to perform cardiac rehab anywhere.
    

Intervention name(s): Remote Cardiac Rehab
Intervention type(s): Device
Intervention description(s): Remote Cardiac Rehab
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Cardiac Rehabilitation
Dermatological Evaluation of Topic Compatibility-Dermacyd Delicata Pocket BR
Condition: Healthy
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to demonstrate the absence of irritation potential (primary
      dermal irritability and cumulated dermal irritability) and allergy (sensibilization) of the
      product Dermacyd Pocket BR.
    


Intervention name(s): Lactic acid (Dermacid)
Intervention type(s): Drug
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: hygiene
Effectiveness of Oral Insulin in Unstable Type 1 Diabetes Patients
Condition: Brittle Type I Diabetes Mellitus
MeSH terms: Diabetes Mellitus, Type 1
Study type: Interventional
Phase: Phase 2

Summary: 
      The intent of the proposed study is to assess the potential of oral insulin to mitigate
      diabetic instability and reduce the frequency and severity of hypoglycemic episodes in
      patients with type 1 diabetes. Restoring hepatic glycogen stores is critical for the
      normalization of counter-regulation to hypoglycemia in these patients. Oral insulin can
      provide a means to increase portal insulin levels, shift the ratio of insulin/glucagon in
      favor of glycogenesis while sparing the patient the risk of hypoglycemia due to peripheral
      hyperinsulinemia
    


Intervention name(s): ORMD 0801
Intervention type(s): Drug
Intervention description(s): 1 capsule ORMD 0801 3 times a day, before each meal
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Hyperglycemia, Exercise, and Endothelial Function
Condition: Endothelial Function; Hyperglycemia
MeSH terms: Hyperglycemia
Study type: Interventional

Summary: 
      The main purpose of this study is to determine if exercise preserves vascular function during
      hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days.
      Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU)
      structured exercise group.
    

Detailed description: 
      Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are
      associated with impaired endothelial function. Both a single bout of exercise and chronic
      exercise training are associated with improvements in vascular endothelial function. It
      remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.
    

Intervention name(s): GLU+EX; GLU
Intervention type(s): Behavioral; Dietary Supplement
Intervention description(s): Subjects will complete 45 minutes of recumbent cycling at 60-65% of age-predicted maximal heart rate five times over seven days while ingesting a 75g glucose beverage three times daily.; Subjects will consume a 75g glucose beverage three times daily over a seven-day period.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: exercise; glucose; vascular function
Effect of Two Different Rye Bread Types in Irritable Bowel Syndrome
Condition: Irritable Bowel Syndrome
MeSH terms: Irritable Bowel Syndrome; Syndrome
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate if low-FODMAP (Fermented Oligo-, Di-,
      Monosaccharides And Polyols) rye bread is better tolerated in irritable bowel syndrome than
      commonly available traditional rye bread higher in FODMAP carbohydrates. The study also aims
      to investigate patients' compliance to rye bread regimen, potential changes is gut microbiota
      and hydrogen production during the test periods (a marker of large bowel fermentation of
      poorly absorbed carbohydrates).
    


Intervention name(s): Traditional Finnish rye bread; Low FODMAP rye bread
Intervention type(s): Other; Other
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: IBS, irritable bowel syndrome, functional gastrointestinal disorder, diet, bread, rye, FODMAP, microbiota