bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Dry Needling, Static Stretching and IASTM in People With Hamstring Muscle Shortness
Condition: Hamstring Muscle Shortness and Elastographic Examination
Study type: Interventional

Summary: 
      The aim of this study was to investigate the effects of dry needling, static stretching and
      instrument assisted soft tissue mobilization on joint range of motion, performance and muscle
      structure in individuals with Hamstring muscle shortness and to examine the changes in soft
      tissue before and after application with the help of ultrasound elastography.
    

Detailed description: 
      The study was randomly divided into 3 groups. Group 1: Hamstring muscle group of patients for
      5 minutes Instrument Assisted Soft Tissue Mobilization made of stainless steel instruments
      used by soft tissue mobilization by the therapist. In order to reduce friction and increase
      lubricity before application; If there is an unexpected erythema, edema or other unexpected
      side effects, the application will be stopped immediately.

      2.Group: In the Hamstring muscle group of the patients, the acupuncture needles, which are
      made of stainless steel, sterile and disposable, will be applied under the supervision of an
      expert doctor for 30-45 seconds. In case of unexpected side effects, the application will be
      terminated.

      Group 3: Patients' Hamstring muscle group under the supervision of the physiotherapist for a
      total of 5 minutes; A total of 10 repetitions of static tension will be applied for 30
      seconds.

      Before starting the study, anthropometric measurements, vertical and horizontal jump amounts
      of all participants will be measured before the application. Digital inclinometer will be
      used to determine the range of motion of the joint. Measurements will be made before and
      after the first application and the last measurement will be made 3 days after the end of 12
      sessions. In addition, soft tissue changes in the hamstring muscle of the participants will
      be evaluated by US elastography before and at the end of the 12th session.
    

Intervention name(s): Dry needling
Intervention type(s): Other
Intervention description(s): Group 1: Dry needling Group 2: static stretching Group 3: IASTM
Other intervention name(s): IASTM, Static stretching
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Health Services Research
Keywords: Hamstring Shortness; Dry Needling; Elastography
Therapeutic Exercise and Vegan Diet on Pain and Quality of Life
Condition: Chronic Idiopathic Neck Pain
MeSH terms: Neck Pain
Study type: Interventional

Summary: 
      45 sedentary volunteer female individuals whose age range is between 18-25 years and
      diagnosed with chronic idiopathic neck pain by a specialist physical therapy doctor will
      participate in the study. Participants will be randomly divided into three groups: vegan diet
      group (n=15), therapeutic exercise group (n=15) and control group (n=15). Participants with
      chronic neck pain who will be on a vegan diet will follow a diet program prepared by an
      expert dietitian under the supervision of an endocrinologist. In this diet program, a diet
      that includes grains, fruits, vegetables, legumes, as well as dairy products and eggs, known
      as lacto-ovo vegetarian, will be applied. Consumption of meat, poultry, fish, seafood and
      processed food and beverages will not be allowed. There will be no calorie restriction in the
      diet, and the diet will be arranged according to the amount of calories calculated by the
      expert dietitian according to BMI. The diet will last eight weeks. Individuals who follow a
      diet will be constantly checked by the workers with the mobile device application (My Fitness
      Pal®). Individuals in the therapeutic exercise group will perform therapeutic exercises for
      eight weeks, 3 days a week, accompanied by a specialist physiotherapist.The aim of this study
      is to compare the Effect of Therapeutic Exercise and Vegan Diet on Pain and Quality of Life
      in Young Women with Chronic Idiopathic Neck Pain.
    


Intervention name(s): Vegan Diet; Therapeutic exercise
Intervention type(s): Other; Other
Intervention description(s): Participants with chronic neck pain who will be on a vegan diet will follow a diet program prepared by an expert dietitian under the supervision of an endocrinologist. In this diet program, a diet that includes grains, fruits, vegetables, legumes, as well as dairy products and eggs, known as lacto-ovo vegetarian, will be applied. Consumption of meat, poultry, fish, seafood and processed food and beverages will not be allowed. There will be no calorie restriction in the diet, and the diet will be arranged according to the amount of calories calculated by the expert dietitian according to BMI. The diet will last eight weeks. Individuals who follow a diet will be constantly checked by the workers with the mobile device application (My Fitness Pal®).; Individuals in the therapeutic exercise group will perform therapeutic exercises for eight weeks, 3 days a week, accompanied by a specialist physiotherapist.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
BivaliRudin in Acute Myocardial Infarction vs Glycoprotein IIb/IIIa and Heparin :a Randomised Controlled Trial.
Condition: Acute Myocardial Infarction; Percutaneous Coronary Intervention
MeSH terms: Myocardial Infarction; Infarction
Study type: Interventional
Phase: Phase 4

Summary: 
      The study would enrolled a total of 2100 AMI patients undergoing PCI to one of three
      antithrombotic regimens: bivalirudin alone, or unfractionated heparin alone, or
      unfractionated heparin plus a glycoprotein IIb/IIIa inhibitor.

      All enrolled patients would be followed-up to 30 days, 6 months, and 1 year. The purpose of
      the study is to evaluate the efficacy and safety of bivalirudin in AMI patients with DES.
    

Detailed description: 
      This is a prospective, randomized, single-blind, active drug controlled multicenter clinical
      research and the study would enrolled a total of 2100 AMI patients undergoing percutaneous
      coronary intervention (PCI) to one of three antithrombotic regimens: bivalirudin alone, or
      unfractionated heparin alone, or unfractionated heparin plus a glycoprotein IIb/IIIa
      inhibitor. All enrolled patients would be followed-up to 30 days, 6 months, and 1 year. The
      purpose of the study is to evaluate the efficacy and safety of bivalirudin in AMI patients
      with DES.
    

Intervention name(s): Bivalirudin; heparin; heparin plus tirofiban
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Patients would be given anticoagulant therapy with bivalirudin in acute myocardial infarction during emergency PCI operation.; heparin monotherapy; combined use of heparin and tirofiban during PCI
Other intervention name(s): Taijianing; brand name of tirofiban: Xinweining
Intervention MeSH terms: Heparin; Calcium heparin; Tirofiban; Bivalirudin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Bivalirudin; Acute myocardial infarction; percutaneous transluminal coronary angioplasty
Study to Investigate the Ability of [11C]Donepezil PET to Image the Parasympathetic Nervous System
Condition: Parkinson's Disease
MeSH terms: Parkinson Disease
Study type: Observational

Summary: 
      AIM: To validate the tracer [11C]donepezil for use in the parasympathetic nervous system.

      MATERIALS AND METHODS: The Investigators will include 7 healthy males aged 45-75 in our
      study. The participants will receive a careful medical examination, including a neurological
      examination, as part of the inclusion process. The subjects also have an MRI scan of the
      brain. PET/CT scans with [11C]donepezil are conducted. Six subjects will receive two PET/CT
      scans - once for the upper abdominal region and once for the head region two evaluate dynamic
      binding characteristics of the tracer in internal organ. Additionally, one single subject
      will receive 5 consecutive whole body PET scans to estimate radioactive dosimetry of this
      tracer.

      PERSPECTIVES: The study will potentially result in the development of a PET ligand for
      imaging the parasympathetic nervous system. This will have applications for research in
      Parkinson's disease, diabetes, heart disease and other disorders, in which the autonomic
      nervous system is involved
    

Detailed description: 
      Please see the published paper wherein all details are listed:

      In vivo imaging of human acetylcholinesterase density in peripheral organs using
      11C-donepezil: dosimetry, biodistribution, and kinetic analyses.

      Gjerløff T, Jakobsen S, Nahimi A, Munk OL, Bender D, Alstrup AK, Vase KH, Hansen SB, Brooks
      DJ, Borghammer P. J Nucl Med. 2014 Nov;55(11):1818-24.
    

Intervention name(s): [11C]donepezil PET
Intervention type(s): Other
Intervention description(s): Positron Emission Tomography (PET) imaging of acetylcholinesterase with the ligand [11C]donepezil
Intervention MeSH terms: Donepezil
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        7 healthy male volunteers is included in this study.
The Effect of a Reduced Noise Environment on Induction and Emergence Behavior in Children Undergoing General Anesthesia
Condition: Surgery; Noise Exposure
Study type: Interventional

Summary: 
      This project will investigate whether reduction in ambient light and elimination of noise on
      induction of anesthesia alters anxiety (modified Yale Preoperative Anxiety Scale or mYPAS) or
      compliance (induction compliance checklist or ICC scoring), alters recovery following
      emergence using pain scores, analgesic requirements, and emergence delirium (post anesthesia
      emergence delirium or PAED), or post-discharge behavior at 1, 7 and 14 days (modified post
      hospitalization behaviour questionnaire or PHBQ) in patients who receive anxiolytic
      premedication. In addition, the investigators will assess the cumulative level of nose
      exposure that patients experience during the perioperative period.
    


Intervention name(s): Noise reduction
Intervention type(s): Other
Intervention description(s): All activity will cease when the patient enters the operating room and nonessential personnel will be removed. Ambient lighting will be reduced and communication devices muted.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Neoadjuvant Androgen Deprivation Therapy Plus Abiraterone With or Without Apalutamide for High-Risk Prostate Cancer
Condition: Prostate Cancer
MeSH terms: Prostatic Neoplasms
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a randomized study to evaluate the efficacy and safety neoadjuvant androgen
      deprivation therapy with goserelin and abiraterone with or without apalutamide prior to
      radical prostatectomy for patients diagnosed with localized high-risk prostate cancer.
    

Detailed description: 
      In the prostate specific antigen (PSA) era, about 15% to 20% of patients are diagnosed with
      high-risk localized disease and radical prostatectomy is a standard therapy for this subgroup
      of patients. However, despite best local therapy, about 30-60% of high-risk patients will
      eventually develop biochemical relapse and a significant proportion of these patients may
      progress with metastatic disease and die from prostate cancer. Currently, there is no data
      supporting the use of neoadjuvant therapy for patients with high-risk disease since studies
      failed to demonstrate clinically significant benefit with standard androgen deprivation
      therapy (ADT). Following improved outcomes in other malignancies with the use of neoadjuvant
      therapy with active drugs in the metastatic setting, there is a growing interest in
      evaluating new-generation androgen receptor (AR)-targeted therapy in earlier stages of
      prostate cancer. Therefore, the goal of this study is to evaluate the efficacy and safety of
      neoadjuvant therapy with ADT and abiraterone versus maximal androgen blockade using ADT,
      abiraterone and apalutamide for patients with high-risk localized prostate cancer.
    

Intervention name(s): Goserelin; Prednisone; Abiraterone; Apalutamide
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Androgen Deprivation Therapy; Corticosteroid; CYP17 inhibitor; Androgen-receptor antagonist
Other intervention name(s): ADT; Zytiga; ARN-509
Intervention MeSH terms: Prednisone; Goserelin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Neoadjuvant therapy; High-risk Prostate Cancer
A Study To Assess The Safety Of PF-05335810 In Hypercholesterolemic Subjects
Condition: Hypercholesterolemia
MeSH terms: Hypercholesterolemia
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is to evaluate the safety, tolerability and immunogenicity of single, ascending or
      multiple fixed subcutaneous and intravenous administrations of PF 05335810 to
      hypercholesterolemic subjects when added on to a daily statin dose.
    


Intervention name(s): PF-05335810 Dose A; PF-05335810 Dose B; Placebo; PF-05335810 Dose B; Placebo; PF-04950615 Dose A; PF-04950615 Dose A; PF-05335810 Dose C; Placebo; PF-05335810 Dose C; Placebo; PF-04950615; PF-05335810 Dose D; Placebo; PF-05335810 Dose E; PF-05335810 Dose D; Placebo
Intervention type(s): Biological; Biological; Biological; Biological; Biological; Biological; Biological; Biological; Biological; Biological; Biological; Biological; Biological; Biological; Biological; Biological; Biological
Intervention description(s): Single SC Injection; Single Subcutaneous Injection(s); Single Subcutaneous Injection(s); Single Intravenous Infusion; Single Intravenous Infusion; Single Subcutaneous Injection(s); Single Intravenous Infusion; Single Subcutaneous Injection(s); Single Subcutaneous Injection(s); Single Intravenous Infusion; Single Intravenous Infusion; Single Subcutaneous Injection(s); Single Subcutaneous Injection(s); Single Subcutaneous Injection(s); Multiple fixed dosages administered in subcutaneous injections, monthly for 3 months.; Single Intravenous Infusion; Single Intravenous Infusion
Intervention MeSH terms: Bococizumab; Antibodies, Monoclonal
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: High Cholesterol; Dyslipidemia
Cash Transfers to Increase Dietary Diversity in Grand Gedeh County, Liberia
Condition: Malnutrition, Child
MeSH terms: Malnutrition; Child Nutrition Disorders
Study type: Interventional

Summary: 
      The investigators aim to evaluate the efficacy of a cash transfer and nutrition education
      program delivered by community health assistants to increase dietary diversity among children
      6 to 23 months of age in Grand Gedeh County, Liberia.
    

Detailed description: 
      Worldwide, more than one in five children suffer from chronic malnutrition. In Liberia, there
      are more than 230,000 children suffering from chronic malnutrition and 32% of children under
      five are stunted. Previous studies have shown that inadequate dietary diversity is strongly
      associated with stunting in children under two years of age. An interventional package
      including cash transfers and education has the potential to improve dietary diversity and
      long-term outcomes such as improved growth and reduced rates of stunting among children.

      The investigators' objective is to evaluate the efficacy of a cash transfer and nutrition
      education program delivered by community health assistants to increase dietary diversity
      among children 6 to 23 months of age in Grand Gedeh County, Liberia. The investigators will
      conduct a pilot, cluster randomized trial in 45 communities. The investigators hypothesize
      that a multi-pronged interventional package aimed at strengthening the household environment
      will result in improved dietary diversity for children 6 to 23 months of age. Moreover, the
      investigators also hypothesize that unconditional cash transfers will result in improved
      dietary diversity for children 6 to 23 months of age in Grand Gedeh County, Liberia.
    

Intervention name(s): Cash Transfer; Cash Transfers and Nutrition Education
Intervention type(s): Other; Other
Intervention description(s): Monthly cash transfers; Cash transfers every month and structured nutrition education provided at household level by community health assistants based on a nutrition education handbook
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Cash Transfers; Liberia; Stunting; Dietary diversity
A Randomized Controlled Trial of Inhaled Amphotericin B for Maintaining Remission in Allergic Bronchopulmonary Aspergillosis
Condition: Allergic Bronchopulmonary Aspergillosis
MeSH terms: Aspergillosis; Pulmonary Aspergillosis; Aspergillosis, Allergic Bronchopulmonary
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      Inhaled amphotericin, a antifungal drug would decrease Aspergillus colonization and decrease
      the occurrence of exacerbations of Allergic Bronchopulmonary Aspergillosis (ABPA).
    


Intervention name(s): Inhaled budesonide; Inhaled amphotericin
Intervention type(s): Drug; Drug
Intervention description(s): The control group will receive only nebulized budesonide 1 mg b.i.d. thrice a week for four months. Patients will also receive a metered dose inhaler of formoterol/budesonide (6/200) at a dose of 2 puffs b.i.d. and as and when required [max 10 puff/day]. The first dose will be administered under direct supervision. If the first dose is tolerated, therapy would be continued for the total duration of the study (4 months). The patient will be advised to clean the nebulizer chamber with soap and water after each administration to avoid contamination.; Amphotericin B deoxycholate (50 mg) will be dissolved in 10 mL sterile water for injection (5 mg/mL). The solution remains stable for at least 7 days at 2°C to 8°C. Ten milligrams of the drug (2 mL) will be nebulized over 10-15 minutes twice in a day for three times a week (Effective dose: 10 mg b.i.d. thrice a week) using a jet nebulizer. Nebulized budesonide will be administered at a dose of 1 mg b.i.d. thrice a week after nebulization with amphotericin B. The total duration of therapy would last 4 months. Patients will also receive a metered dose inhaler of formoterol/budesonide (6/200) at a dose of 2 puffs b.i.d. and as and when required [max 10 puff/day].
The first dose will be administered under direct supervision.
Intervention MeSH terms: Amphotericin B; Liposomal amphotericin B; Budesonide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: ABPA
Safety and Efficacy Evaluation of Oxybutynin Topical Gel In Children With Neurogenic Bladder
Condition: Overactive Detrusor; Neurogenic Bladder
MeSH terms: Urinary Bladder, Neurogenic; Urinary Bladder, Overactive
Study type: Interventional
Phase: Phase 4

Summary: 
      This study will evaluate the safety and efficacy of Oxybutynin Chloride 10% Topical Gel in
      children 3 to less than 17 years old, who have overactive bladder due to a neurogenic
      condition. Children will be treated with 0.75 g of gel/day for two weeks. Patients will then
      return to the clinic for a potential dose titration. At this time their dose may be adjusted
      up to 1g/day, down to 0.5g/day, or remain the same at 0.75g of gel/day depending on the
      individual response and tolerability. The total treatment time is 14 weeks and total time on
      the study is 16 weeks.
    

Detailed description: 
      This study will use a two-part, multicenter, dose-titration study in pediatric patients with
      a detrusor overactivity associated with a neurological condition
    

Intervention name(s): Oxybutynin
Intervention type(s): Drug
Intervention description(s): 10% Oxybutynin Chloride Topical Gel, 0.5 g, 0.75 g, and 1 g/day, administered transdermally.
Other intervention name(s): Gelnique
Intervention MeSH terms: Oxybutynin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Effect of Sodium Alginate on Appetite Sensation
Condition: Obesity; Overweight
MeSH terms: Overweight
Study type: Interventional
Phase: Phase 1

Summary: 
      The aim of the study is to investigate the effects of a low-calorie alginate containing fruit
      flavored beverage on appetite and body weight development.
    

Detailed description: 
      The project consists of two different studies:

      Study I: A randomised controled meal test study aimed at studying the acute effect of the
      alginate-containing beverage on appetite sensation and spontaneous calorie intake (and safety
      i.e. nausea, well-being etc) in normal to overweight healthy subjects. Here, a placebo
      beverage or the alginate-containing beverage will be administered as a pre-load before a
      standardised breakfast meal. Subjective appetite sensation will be measured with Visual
      Analogue Scale (VAS) every 30 minutes four up to 5 hours. An additional beverage will be
      administered prior to an ad libitum lunch meal, where spontaneous water and energy intake
      will be registered.

      Study II: Secondly the aim is to study the effects of a daily intake of a placebo or
      alginate-containing beverage on body weight and composition in a randomised parallel
      intervention study of 12 weeks duration. A total of app. 50 obese healthy adults will receive
      a hypocaloric diet and be randomised to consume either placebo or alginate-containing
      beverage before each of the three main meals every day. The development in body weight and
      composition and blood pressure will be monitored and blood samples will be analysed for
      markers related to the risk of CVD and type 2 diabetes.
    

Intervention name(s): Alginate; Alginate; Placebo; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): a 500 ml alginate beverage per meal test; a 330 ml alginate beverage per meal test; a 500 ml placebo beverage per meal test; a 330 ml placebo beverage per meal test
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Appetite; Energy intake; gastric emptying; well being; Body weight