bioihbjkbjnl/mcl2 huggingface dataset:
Effect of COVID-19 Infection on the Performance of Adolescent Professional Overhead Athletes
Condition: COVID-19; Sport Performance, Professional Overhead Athletes
MeSH terms: COVID-19
Study type: Observational

Summary: 
      COVID-19 is known to also cause damage outside the pulmonary system, particularly the
      cardiovascular and the musculoskeletal system. The studies on the effects of COVID-19
      infection on different populations may provide valuable information for health professionals.
      Derangements in the cardiorespiratory and musculoskeletal systems which normally direct
      effect on the sports performance of athlete together with physical inactivity during COVID-19
      infection are the main factors that may decrease the performance of the professional
      athletes. Although it may be well anticipated that COVID-19 will reduce sports performance;
      there are scarce studies in the literature. The aim of this study is to compare the sports
      performance of adolescent athletes that has COVID-19 infection with those did not.
    

Detailed description: 
      Extensor muscle endurance, flexor muscle endurance and the lateral core muscle endurance were
      evaluated. All tests were performed by a chronometer and test was terminated as the position
      was lost and the time passed was recorded. Hand grip strength was measured by Jamar hand
      dynamometer. Health ball throwing test was used to evaluate upper extremity open kinetic
      chain and explosive power. Pro-agility test was used to evaluate the agility. Step test was
      performed for 3 minutes with a 30 cm high step board.
    

Intervention name(s): Evaluation of core muscle endurance, hand grip strength, upper extremity functional performance, reaction time, agility performance and 3 minutes step test
Intervention type(s): Diagnostic Test
Intervention description(s): Core muscle endurance was evaluated with extensor muscle endurance test, flexor muscle endurance test and lateral muscle endurance test.
Hand Grip Strength was evaluated with Jamar hand dynamometer. Upper extremity functional performance was evaluated with health ball throwing test.
Reaction time was evaluated with Fitlight Trainer. Agility performance was evaluated with Pro-agility test. Cardiovascular endurance was evaluated with the 3-minute step test.
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Professional athletes
      
Keywords: COVID-19; sport performance; adolescent athletes; overhead sport
Parental Notions and Clinical Experiences About Child's Gut Comfort, Overall Satisfaction and Sense of Well-being When Consuming a New Toddler Milk
Condition: Digestion; Happiness; Temperament
Study type: Interventional

Summary: 
      This is a prospective, open-label, single-arm study in a real-world setting of healthy
      Chinese toddlers provided with new toddler milk for a total of 4 weeks (28 days).
    

Detailed description: 
      The new toddler milk contains prebiotic and an optimized fat blend of bovine milk fat,
      vegetable fats, and a LC-PUFA oil mixture (providing DHA and ARA). The prebiotic and bovine
      milk fat-based blend have shown to be able to improve digestive comfort and milk taste.
      Physiological factors such as physical discomfort has been shown to be associated with
      negative emotionality and temperament (Putnam 2012). Therefore, the investigators hypothesize
      that by improving digestive comfort, they are able to influence child temperament, happiness,
      and other behavioral characteristics.
    

Intervention name(s): Toddler Milk
Intervention type(s): Dietary Supplement
Intervention description(s): At least three 130 mL servings daily of study formula are recommended for a total daily intake of 390 mL. Study participants will continue this feeding regimen Days 4 to 28 (approximately 4 weeks).
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: prebiotic; digestion; child development; temperament
A Single Dose Study of LY2189265 in Subjects With Varying Degrees of Hepatic (Liver) Impairment
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary purpose of this study is to help answer the following research questions, and not
      to provide treatment for any condition:

        -  To evaluate how much of the study drug (LY2189265) is in the blood of participants with
           varying degrees of liver impairment compared to those with normal liver function.

        -  To assess the safety of LY2189265 and any side effects that might be associated with it.
    


Intervention name(s): LY2189265
Intervention type(s): Drug
Intervention description(s): Subcutaneous (SC) injection
Other intervention name(s): Dulaglutide
Intervention MeSH terms: Dulaglutide
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effectiveness of Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT) for Children With Post-traumatic Stress Disorder (TreatChildTrauma)
Condition: Post-Traumatic Stress Disorder
MeSH terms: Stress Disorders, Traumatic; Stress Disorders, Post-Traumatic
Study type: Interventional

Summary: 
      This multi-site randomized controlled trial compares the effectiveness of Trauma-Focused
      Cognitive-Behavioral Therapy (TF-CBT) as developed by Cohen, Mannarino & Deblinger (2006)
      with a wait-list condition in a population of children aged 7-16 years who were exposed to
      traumatic events beyond the age of three years, at least three months ago, and developed
      Posttraumatic Stress Disorder (PTSD). Primary aims are to provide evidence that TF-CBT
      exceeds spontaneous remission of posttraumatic stress symptoms and to assess maintenance of
      treatment gains at 6 and 12 months post-treatment. Secondary aims are to evaluate the
      effectiveness of TF-CBT in reducing other psychopathology and cognitive distortions of
      patients and caregivers and to explore moderators and mediators of treatment response. The
      trial will contribute to implement an evidence-based treatment for traumatized children
      across a variety of healthcare settings in Germany. The novel aspect is to evaluate the
      effectiveness of TF-CBT with a broad range of traumatized "real-world" patients in the
      context of the German mental healthcare system.
    

Detailed description: 
      Complete study protocol (in German) available from the PI lutz.goldbeck@uniklinik-ulm.de
    

Intervention name(s): Trauma-Focused Cognitive Behavioral Therapy (TF-CBT)
Intervention type(s): Behavioral
Intervention description(s): TF-CBT (see also HThttp://tfcbt.musc.eduTH) is a manualised intervention for traumatized children and adolescents 7 to 16 years old and their parent/caregiver. The primary components are summarized by the acronym PRACTICE: Parenting skills, Psychoeducation, Relaxation, Affect modulation, Cognitive processing, Trauma narrative, In vivo mastery of trauma reminders, Conjoint child-parent session, and Enhancing safety and future development. We will use the manual as provided by Cohen et al. and available in German. The treatment program will comprise 12 sessions with children and parents (partly separated, partly conjoined sessions) of 90 minutes each. The 12 sessions will be distributed over a duration of 16 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: PTSD; Children and Adolescents; Post-Traumatic Stress Disorder in Children and Adolescents
Study of LLG783 in Patients With Peripheral Artery Disease (PAD) and Intermittent Claudication
Condition: Peripheral Artery Disease (PAD); Intermittent Claudication
MeSH terms: Peripheral Arterial Disease; Intermittent Claudication
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is designed to determine whether LLG783 displays the clinical safety and efficacy
      profile, after multiple i.v. doses, to support further development in patients with PAD and
      intermittent claudication.
    


Intervention name(s): LLG783; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): LLG783 concentrate solution for infusion/injection suitable for i.v. administration as well as s.c. administration.; Placebo to LLG783 concentrate solution for infusion/injection suitable for i.v. administration as well as s.c. administration.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized, patient and investigator-blinded, placebo controlled, parallel group study
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: PAD; peripheral artery/arterial disease; peripheral vascular disease; leg pain; claudication; leg pain with exercise; exercise test; walk test
Adult Oxytocin Study
Condition: Schizophrenia; Oxytocin; Social Cognition
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Early Phase 1

Summary: 
      In this study, investigators will examine the behavioral effects and neurophysiological
      mechanisms of the pro-social neuropeptide oxytocin in patients with recent-onset
      schizophrenia. Such research is a necessary first step towards identifying whether intranasal
      oxytocin administration can serve as an adjunct treatment for social impairments in
      schizophrenia.

      Aim 1: To quantify the effects of exogenous oxytocin on social cognition and behavior in
      patients with recent-onset schizophrenia.

      Hypothesis A: Patients and healthy comparison subjects will show enhanced social cognition
      (e.g., improved interpretation of paralinguistic and emotional cues, such as those involved
      in emotional or sarcastic communication) after administration of oxytocin versus placebo.

      Hypothesis B: Patients and healthy comparison subjects will show increased attention to
      others' eyes and patients will exhibit increased facial affect expressivity after
      administration of oxytocin versus placebo.

      Aim 2: To examine the effects of exogenous oxytocin on persistent negative symptoms in
      schizophrenia (PNS) activity in patients with recent-onset schizophrenia.

      Hypothesis A: Patients and healthy comparison subjects will demonstrate increased PNS
      activity during social tasks after administration of oxytocin versus placebo.

      Hypothesis B (exploratory): Patients and healthy comparison subjects' improvements in social
      cognition and behavior will be predicted by the degree to which oxytocin increases their PNS
      activity.
    


Intervention name(s): Oxytocin; Saline Nasal Spray
Intervention type(s): Drug; Drug
Intervention description(s): 40 IU of the oxytocin will be administered intranasally for a one time dose at the beginning of the visit.; 40 IU of the saline nasal spray will be administered once at the beginning of the visit.
Other intervention name(s): Syntocinon; Placebo
Intervention MeSH terms: Oxytocin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Oxytocin; Syntocinon; Social Cognition; Schizophrenia
MPOWERed Messages: Tailored Mobile Messages to Enhance Weight Loss for Teens
Condition: Obesity
MeSH terms: Weight Loss
Study type: Interventional

Summary: 
      Obesity affects millions of American children and increases their risk of adult obesity, a
      myriad of serious illnesses, increased healthcare costs, and premature death. It is vital to
      find ways to reverse this epidemic. Multidisciplinary behavioral weight management programs
      offer the promise of effectively treating childhood obesity. However, participants in such
      programs often find it challenging to follow recommended treatment plans and frequently drop
      out from programs without completing them. The proposed project aims to address these
      problems through frequent contact with patients between office visits. This interim contact
      will be achieved by automatically sending tailored messages to the mobile phones of
      adolescents enrolled in a multidisciplinary weight management program (the MPOWER program),
      as an adjunct to clinic visits.

      The investigators hypothesize that program participants who receive the tailored text
      messages will experience lower attrition rates, increased treatment adherence, and greater
      weight loss compared to those program participants who do not receive the messages.
    


Intervention name(s): Tailored Mobile Messages to Enhance Weight Loss for Teens
Intervention type(s): Behavioral
Intervention description(s): For this trial adolescents will be allowed to use their own phone (with reimbursement for any study-related costs), or will be provided with a mobile phone, if requested. Participants will receive messages delivered daily over the course of 20 weeks. The content of the messages will be tailored on participants' responses to the MPOWER enrollment survey and the initial tailoring questionnaire. On school days, all messages will be sent after 3 pm (which is after school hours for most Michigan middle and high schools). Therefore, patients will not need to carry cell phones to school. The tailored messages will utilize various degrees of personalization, adaptation and feedback - including momentary assessments with feedback requiring a text reply from the adolescents.
Other intervention name(s): MPOWERed Messages
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Obesity; Treatment; Adolescents; Text Messages; Mobile phones; Multidisciplinary
Symptomatic Gastroesophageal Reflux Disease: Double Blind Randomized Controlled Study of On-demand Therapy Versus Maintenance Therapy
Condition: Gastroesophageal Reflux Disease
MeSH terms: Gastroesophageal Reflux; Esophagitis, Peptic
Study type: Interventional
Phase: Phase 3

Summary: 
      Maintenance treatment with proton pump inhibitor (PPI) is the most widely recommended
      modality of treatment for long-term management of gastroesophageal reflux disease (GERD). Yet
      in clinical practice treatment is commonly given in short courses on as required basis during
      symptom flare up, particularly for patients with mild to moderate GERD.

      On-demand therapy also has the potential advantage that patient does not need to take regular
      medications, thereby improving the quality of life. However, whether on-demand PPI therapy
      achieves similar efficacy of symptom control is uncertain.

      The aim of this study is to compare the efficacy and quality of life of on-demand and
      maintenance PPI regimens in long-term management of non-erosive GERD patients. The
      investigators hypothesize that on-demand PPI treatment is as effective as maintenance PPI.
    


Intervention name(s): Esomeprazole
Intervention type(s): Drug
Intervention MeSH terms: Esomeprazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: GERD
Use of Pyridostigmine for Constipation in Diabetics
Condition: Constipation; Diabetes Mellitus; Colonic Transit; Gastric Emptying
MeSH terms: Constipation
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Doctors at Mayo Clinic are doing this study to learn if pyridostigmine, a drug, affects the
      speed at which food travels through the stomach, intestines and colon, and if pyridostigmine
      improves constipation symptoms in patients with diabetes. Pyridostigmine has been approved by
      the Food and Drug Administration (FDA) for routine clinical use, however, its use as proposed
      in this study is considered investigational.
    

Detailed description: 
      Chronic constipation in diabetes mellitus is associated with colonic motor dysfunction and is
      managed with laxatives. Cholinesterase inhibitors increase colonic motility. The study
      evaluated the effects of a cholinesterase inhibitor (pyridostigmine vs. placebo) on
      gastrointestinal and colonic transit and bowel function in diabetic patients with
      constipation.

      After a 9-day baseline period, patients with diabetes mellitus and chronic constipation
      without defecatory disorder will be randomized to oral placebo or pyridostigmine, starting
      with 60 mg three times a day, increasing by 60 mg every third day up to the maximum tolerated
      dose of 120 mg three times a day; this dose will be maintained for 7 days. Gastrointestinal
      and colonic transit (assessed by scintigraphy) and bowel function will be evaluated at
      baseline and the final 3 and 7 days of treatment, respectively.
    

Intervention name(s): Pyridostigmine; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Pyridostigmine will be started at (60mg) tid, increased over 10 days to 120 mg tid, and maintained at that dose for 7 days.; If subject is randomized to placebo, placebo pills will be started at (60mg) tid, increased over 10 days to 120 mg tid, and maintained at that dose for 7 days.
Other intervention name(s): Mestinon
Intervention MeSH terms: Pyridostigmine Bromide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Good Shepherd: Back to Reality Series
Condition: Knowledge
Study type: Interventional

Summary: 
      The purpose of this pilot study is to explore whether the Back to Reality series of video
      games - Harry's Journey, Harry's Journal, and Pathways to care map - increase knowledge of
      the emotional, social, and psychiatric sequelae of problematic underage marijuana use among
      homeless and street involved youth. Additional objectives were to explore whether the video
      games promote awareness of the risk of psychosis associated with regular marijuana use among
      vulnerable youth.
    

Detailed description: 
      This project pilots the use of educational video games designed to help youth gain awareness
      of the risk of mental health issues associated with regular marijuana use. By playing the
      Back to Reality video games, youths may absorb knowledge about where and how to access
      community care for symptoms associated with psychosis and problematic cannabis use. The
      purpose of this study is to pilot test the use of the Back to Reality series at increasing
      awareness of the social and emotional implications of underage substance use.

      This study explores the effects of the Back to Reality video games compared to control video
      games (no content about mental health and addiction). Street involved and homeless youth
      registered with Good Shepherd services between the ages of 16 and 19 years of age will be
      recruited. The results will be assessed using quantitative questionnaires and qualitative
      interviews. The data will be statistically analyzed for significant differences in knowledge
      about the risk of psychosis linked to marijuana use among vulnerable youth. The qualitative
      interview assesses the participants understanding and views of potential emotional, social,
      and psychiatric sequelae associated with excessive marijuana use during.
    

Intervention name(s): Back to Reality Series Video Games; Control Video Game
Intervention type(s): Other; Other
Intervention description(s): Back to Reality Series are a psycho-educational video games that provide information about psychosis and marijuana use from the perspective of 'Harry': a character who experiences problems with both issues. The aim is for players to learn how to detect some signs of psychosis and where to seek help for mental health and addictions problems.; The control video game consists of digital puzzles and spelling game about pop culture. The control games does not have any content related to mental health and addictions problems
Other intervention name(s): Harry's Journal, Harry's Journey, Harry's PathwaysToCare map; Morpheus' Spell
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: marijuana use; psychosis; youth; video game
Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression
Condition: Treatment Resistant Depression; Major Depressive Disorder; Severe Depression
MeSH terms: Depression; Depressive Disorder; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant
Study type: Interventional

Summary: 
      In this proof of concept study, the investigators plan to administer iv ketamine interleaved
      with ECT days.

      Patients with treatment resistant depression who are deemed to be eligible for ECT treatment
      will randomly be assigned to either ketamine or active placebo.
    

Detailed description: 
      The study will compare the effects of standard ketamine dosing with an active placebo arm.

      Hypothesis 1:

      The investigators hypothesize that interleaved Electroconvulsive Treatment and active
      ketamine treatment will lead to a meaningful clinical improvement compared to
      Electroconvulsive Treatment and placebo treatment arm.

      Hypothesis 2:

      The investigators hypothesize that interleaved Electroconvulsive Treatment and active
      ketamine treatment will attenuate cognitive side effects.

      Methods and Design:

      Patients with treatment resistant depression who are deemed to be eligible for
      Electroconvulsive Treatment will randomly be assigned to either ketamine or active placebo

      Electroconvulsive Treatments:

      All patients (independent of their depression scores) will receive the same Electroconvulsive
      Treatment parameters: Bi-frontal brief pulse (0.5 miliseconds) Electroconvulsive Treatment
      administered by using Thymatron Electroconvulsive Treatment machine.

      Study blinding:

      Neither the patients, nor the treating psychiatrist or the nurse will be aware of the
      patient's assigned arm. The success of blinding will be tested after each ketamine treatment
      with a questionnaire given to the subject, raters, and treating physician.
    

Intervention name(s): Ketamine; Midazolam
Intervention type(s): Drug; Drug
Intervention description(s): inter venous injections; inter venous injections
Other intervention name(s): Ketalar; Calypsol; Ketanest; Tekam; Dormicum; Hypnovel; Versed
Intervention MeSH terms: Midazolam; Ketamine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Ketamine; Electroconvulsive Therapy; Major Depressive Disorder; Treatment Resistant Depression; electroconvulsive treatment; Severe depression