bioihbjkbjnl/mcl2 huggingface dataset:
A Pilot Study of Physical Activity for Improving Quality of Life in Prostate Cancer Patients on Androgen Deprivation Therapy (ADT)
Condition: Prostate Cancer
MeSH terms: Prostatic Neoplasms
Study type: Interventional

Summary: 
      60 eligible subjects will be randomized into one of three study arms 1) aerobic exercise, 2)
      resistance exercise, or 3) usual care. Baseline measurements will be done on all study
      subjects, these measurements include: height, weight, dual energy x-ray absorptiometry (DXA)
      for bone mineral density and lean body mass measurements, blood will be taken to measure
      serum free testosterone, prostate-specific antigen (PSA), glucose, and insulin levels.
      Fitness will also be evaluated using a graded exercise test. Questionnaires on health and
      personal history will also be completed. Men randomized to the aerobic exercise treatment arm
      will participate in a walking program three times a week for eight weeks. The participants
      will start at 15 minutes per session and increase to a goal of 60 minutes per session. Men
      randomized to the resistance training treatment arm will participate in an eight-week program
      of eight strength training exercises three times per week. Men in the usual care arm will
      receive written materials from the American Cancer Society about coping with cancer, which
      includes information about participation in physical activity. At the end of the eight week
      intervention participants in all three study arms will complete the same questionnaires and
      measurements they completed at baseline.
    


Intervention name(s): walking exercise; weight training; Usual Care
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Subjects will be given an exercise prescription for walking 3 times a week for eight weeks; participants will be given a weight training prescription to do 3 times a week for eight weeks.; Subjects in this arm will continue with their usual care and not start any exercise program for eight weeks.
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: prostate cancer; aerobic exercise; resistance training
Effect of Touch Screen Tablet on Fine Motor Functions
Condition: Hemiplegic Cerebral Palsy
MeSH terms: Cerebral Palsy
Study type: Interventional

Summary: 
      the objective of this study to asses the effect of touch screen tablet on fine motor
      functions
    


Intervention name(s): touch screen tablet
Intervention type(s): Other
Intervention description(s): traditional occupational therapy in addition to games on tablet
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Evaluation of the PneumRx Lung Volume Reduction Coil to Treat Emphysema
Condition: Emphysema
MeSH terms: Pulmonary Emphysema; Emphysema
Study type: Interventional

Summary: 
      The objective of this study is to demonstrate the safety of the PneumRx Lung Volume Reduction
      Coil (LVRC) in a population of patients with emphysema. The PneumRx, Inc. LVRC is a used as a
      less invasive alternative to lung volume reduction surgery. The PneumRx LVRC is designed as
      an alternative to lung volume reduction surgery, potentially achieving the desired reduction
      in lung volume limiting the risks associated with major surgery, such as illness or death.
      This device is deployed through a bronchoscope and requires no incision.
    


Intervention name(s): Lung Volume Reduction Coil (LVRC); Coils
Intervention type(s): Device; Device
Intervention description(s): Implantation of Lung Volume Reduction Coil(s) (LVRC); Lung Volume Reduction Coil(s)
Other intervention name(s): Lung Volume Reduction Surgery (LVRS); Lobectomy; Lung Volume Reduction Surgery (LVRS); Lobectomy
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: LVRS (Lung Volume Reduction Surgery); LVRC (Lung Volume Reduction Coil); Emphysema; coil; RePneu
Comparison of Spontaneous Ventilation Time in Air Without Desaturation After Positive Pressure Extubation Versus Aspiration Extubation When Awakening From General Anesthesia
Condition: Anesthesia, General
Study type: Interventional

Summary: 
      The primary objective is to show that positive pressure extubation improves oxygenation
      immediately after extubation compared to extubation via "aspiration" by evaluating and
      comparing the onset time of desaturation during spontaneous ventilation during awakening
      following general anesthesia.
    


Intervention name(s): Positive pressure extubation; Aspiration/suction extubation
Intervention type(s): Procedure; Procedure
Intervention description(s): Positive pressure extubation will be used for patients waking up from general anesthesia; Aspiration/suction extubation will be used for patients waking up from general anesthesia
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: extubation strategy
Functional Recovery in Critically Ill Children
Condition: Critical Illness; Children
MeSH terms: Critical Illness
Study type: Observational

Summary: 
      Intensive Care Unit-acquired weakness (ICU-AW) is a well-recognized, important and
      preventable sequelae of critical illness, affecting up to 60% of adult ICU patient. ICU-AW is
      associated with increased mortality and length of stay, and negatively impacts long-term
      functional outcomes and quality of life in affected patients and their caregivers. While
      delayed mobilization adversely affects clinical outcomes, early rehabilitation in the
      critically ill adult population is safe, feasible, cost effective, results in more ventilator
      free-days and better functional outcomes at hospital discharge. In contrast, there is a
      paucity of this research in pediatrics. Our research suggests that immobilization is common
      in critically ill children, and rehabilitation is delayed particularly in the sickest
      children who are arguably at highest risk of morbidity. It is unclear however, whether
      delayed rehabilitation leads to adverse outcomes in critically ill children, as has been
      demonstrated in adults. Our objectives of this study are to evaluate if immobilization and
      delayed rehabilitation negatively impacts short-term clinical outcomes and the time to
      functional recovery in critically ill children. The investigators hypothesize that the
      following factors may influence functional recovery and morbidity in critically ill children:

        -  Pre-morbid condition

        -  Age

        -  Time-to-initiation of acute rehabilitation

        -  Critical illness disease severity
    

Detailed description: 
      Overall Study objectives:

        1. To describe the functional recovery following prolonged immobility and delayed
           rehabilitation in critically ill children.

        2. To explore the predictors of impaired functional recovery following immobilization in
           critically ill children.

      Prior to conducting a definitive multi-centre study to answer our research questions and
      achieve our study objectives above, we will conduct a pilot study in order to demonstrate
      feasibility.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Critically Ill Children
      
Keywords: functional recovery, critical illness, pediatrics
Nicotine Replacement and Counseling In Adolescents
Condition: Smoking Cessation
Study type: Interventional
Phase: Phase 4

Summary: 
      The objective of this pilot study is to determine the feasibility and utility of using the
      nicotine nasal spray (NNS) in adolescent smokers who want to quit smoking.
    


Intervention name(s): Nicotine nasal spray; Smoking cessation counseling
Intervention type(s): Drug; Behavioral
Intervention description(s): 8 weeks or counseling plus 6 weeks of nicotine nasal spray (2 sprays each nostril as needed).; 8 weeks or counseling
Intervention MeSH terms: Nicotine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Microbial Soy Milk Consumption, Inflammation and Renal Function Among Type 2 Diabetic Patients With Nephropathy
Condition: Type II Diabetic Patients With Nephropathy
MeSH terms: Kidney Diseases
Study type: Interventional

Summary: 
      The aim of the present study was to determine the effects of fortified soy milk with L.
      planetarium A7 on a cytokine receptor, an adipokine and renal function biomarkers in type II
      diabetic patients with nephropathy.
    


Intervention name(s): probiotic soy milk
Intervention type(s): Dietary Supplement
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Correlation Between Types of Lateral Pterygoid Muscle Attachment and Internal Derangement of the Temporomandibular Joint
Condition: TMJ Disorder
MeSH terms: Temporomandibular Joint Disorders
Study type: Observational

Summary: 
      the study aimed to evaluate the clinical and MRI finding of TMJ AND LPM with predication of
      the risk factors. Study design: this retrospective study included 1365 joints in 800 patients
      diagnosed as TMJ internal derangement and all the patients examined by MRI from 2008 to 2019.
      Cases with loss of continuity of articular disk or the posterior attachment of the disk were
      considered as positive cases.
    

Detailed description: 
      the study aimed to evaluate the clinical and MRI finding of TMJ with LPM with predication of
      the risk factors. Study design: this retrospective study included patients diagnosed as TMJ
      internal derangement and all the patients examined by MRI from 2008 to 2019. Cases with loss
      of continuity of articular disk or the posterior attachment of the disk were considered as
      positive cases.
    

Intervention name(s): MRI
Intervention type(s): Diagnostic Test
Intervention description(s): MRI of TMJ
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        The retrospective study included patients seeking treatment for TMD at Al-Azhar University
        Hospital and the outpatient clinic at the Faculty of Dental Medicine of Al-Azahr
        University. The sample originally included patients who provided consent to participate in
        this study and who ultimately underwent treatment for TMJD between 2008 and 2019.
Which Exercises Should Diabetic Patients do?
Condition: Type2 Diabetes; Physical Activity
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      Type 2 Diabetes Mellitus (DM) is a widespread worldwide disease. Exercise therapy is an
      effective method but which exercise types are more effective is an important question.

      This study was designed to compare the effects of three different exercise programs on
      physical function and quality of life in Type 2 DM. Forty-two patients with Type 2 DM
      participated in the study. The patients were randomly assigned to three groups. Client based
      exercises in accordance with physiotherapy assessment were applied to group 1 (aged
      51.42±4.60 years; body mass index 35.28±4.21 kg/m² kg/m²), Clinical Plates exercises were
      applied to group 2 (aged 53.07 ±5.12 years; body mass index 35.56±4.83 kg/m²) and a standard
      program including calisthenics exercises were applied to group 3 for 12 weeks, 3 days a week.
      6 minutes walk test (6 MWT) and physiological cost index (PCI), timed up and go test (TUG)
      and SF-36 quality of life questionnaire were performed before and after the 12-week exercise
      program.
    


Intervention name(s): Custom Designed Exercises; Plates Exercises; Calisthenics Exercises
Intervention type(s): Other; Other; Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Type 2 Diabetes Mellitus; Exercise; Physical Performance; Physiological Cost Index
Ability to Cope With Type 1 Diabetes
Condition: Depression
MeSH terms: Diabetes Mellitus, Type 1; Depression
Study type: Observational

Summary: 
      The purpose of this study is to learn about the relationship that exists between coping
      skills and blood glucose control. In addition to this, we will study the effect of Type 1
      diabetes on coping skills in different age groups, genders, ethnicities, socioeconomic
      groups, and the duration of diabetes.
    

Detailed description: 
      Coping with type 1 diabetes can be very difficult. Type 1 diabetes is a very unique chronic
      disease because it requires constant attention to several responsibilities such as daily
      glucose monitoring, multiple daily insulin doses, and strict diet and exercise. Several
      studies have shown that increased rates of poorer glucose control are a result of struggling
      to cope with type 1 diabetes. This may be due to the fact that many type 1 diabetics
      experience a feeling of exhaustion, or "burnout," after a certain period of time due to an
      overwhelming amount of responsibility.

      In our study we would like to determine how children's ability to cope with diabetes affects
      glucose control. By completing several questionnaires, we can analyze different kinds of
      coping skills through a complex scoring system. These scores will then be analyzed in
      comparison to your glucose control using HbA1c.
    

Time perspective: Retrospective
Keywords: Depression; Socioeconomic status; Type 1 diabetes mellitus; Children; Adolescents
Pharmacokinetics of Multiple Ascending Doses of VCH-222 in Subjects With Chronic Hepatitis C Infection
Condition: Hepatitis C
MeSH terms: Hepatitis A; Hepatitis C; Hepatitis C, Chronic; Hepatitis
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The purpose of this study is to assess antiviral activity when administered alone for 3 days
      or in combination with peginterferon and ribavirin for 12 weeks. This study will also
      evaluate the safety and tolerability of treatment with VCH-222 when given alone or in
      combination with peginterferon and ribavirin.

      The study will also evaluate the pharmacokinetic profile of VCH-222 in HCV infected subjects.
    


Intervention name(s): VCH-222 or matching placebo; VCH-222 or matching placebo; peginterferon alfa-2a; ribavirin
Intervention type(s): Drug; Drug; Biological; Drug
Intervention description(s): capsule, oral, 4 doses once daily or twice daily, 3 days; capsule, oral, 400 mg twice daily or 750 mg twice daily, 12 weeks; subcutaneous injection, 180 μg, once weekly, 48 weeks; tablet, oral, 1000-1200 mg daily based on body weight, 48 weeks
Other intervention name(s): VCH-222 is also known as VX-222; VCH-222 is also known as VX-222
Intervention MeSH terms: Ribavirin; Peginterferon alfa-2a
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: VX-222
Effects of O2 and/or CO2 Inhalation on Rest and Exercise Pulmonary Hemodynamic
Condition: Pulmonary Vascular Sensibility in Hypoxia; Hypercapnia; Hypoxia and Hypercapnia
MeSH terms: Hypoxia; Hypercapnia
Study type: Observational

Summary: 
      The aim of this study is to describe the pulmonary hemodynamic evolution at rest and during a
      short constant load exercise in 4 conditions :

        -  normoxia

        -  hypoxia

        -  hypercapnia

        -  association hypoxia and hypercapnia
    


Intervention name(s): Hypercapnia inhalation (Altitrainer NP 190); Hypoxia and hypercapnia (Altitrainer NP 190); Hypoxia inhalation (Altitrainer NP 190)
Intervention type(s): Device; Device; Device
Intervention description(s): Hypercapnia inhalation using an Altitrainer NP 190; Hypoxia and hypercapnia inhalation using an Altitrainer NP 190; Hypoxia inhalation using an Altitrainer NP 190
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Healthy volunteers
Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts
Condition: Bone Cyst Aneurysmal; Pathological Fracture; Recurrent Disease; Refractory Tumor
MeSH terms: Cysts; Bone Cysts; Bone Cysts, Aneurysmal; Fractures, Spontaneous
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The efficacy of traditional therapeutic approaches for aneurysmal bone cysts (ABC), such as
      surgery, embolization, sclerotherapy and radiotherapy, are often compromised for lesions in
      axial skeletons and adolescents complicated with pathological fracture. Therefore, denosumab,
      a new drug that has been successfully used in giant cell tumor of bone but has seldom used in
      ABC, was used to treat ABC in this trial.
    

Detailed description: 
      Patients with primary ABC treated with perioperative denosumab in the Musculoskeletal Tumor
      Center of Peking University People's Hospital between January 2014 and December 2016 will be
      reported in this trial.Approved by the Ethics Committee of Peking University People's
      Hospital and with the full informed consent from the patients or their families, all patients
      received surgery and treatment with denosumab perioperatively. Denosumab 120 mg was given
      subcutaneously (abdomen wall or upper arms) every 4 weeks (Q4W), with a loading dose on both
      Day 8 and Day 15 of the first cycle. Meanwhile, all patients were suggested to take 800mg
      oral calcium supplement every day and avoid any dental or oral surgery (tooth extraction,
      tooth filling, etc.). Patients were followed once a month since the date of surgery. On
      follow-up visits, patient-reported adverse reactions, X-ray image of jawbone, serum calcium,
      alkaline phosphatase, renal and hepatic function, hemoglobin, white blood cell, and platelet
      count were collected, and histological examinations, radiological examinations (such as
      X-ray, computed tomography (CT), magnetic resonance image (MRI) and positron emission
      tomography-computed tomography (PET-CT) and postoperative functional status evaluations by
      MSTS（Musculoskeletal tumor society） score were conducted.
    

Intervention name(s): Denosumab (Xgeva)
Intervention type(s): Drug
Intervention description(s): Denosumab (Xgeva) 120 mg was given subcutaneously (abdomen wall or upper arms) every 4 weeks (Q4W), with a loading dose on both Day 8 and Day15 of the first cycle， perioperatively.
Other intervention name(s): surgical treatment
Intervention MeSH terms: Denosumab
Intervention model: Single Group Assignment
Intervention model description: Patients with recurrent and/or refractory aneurysmal bone cysts treated with denosumab perioperatively.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: aneurysmal bone cyst, denosumab, surgical treatment, complication
Study of MAP0010 in Asthmatic Children and Adolescents
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 2

Summary: 
      The objectives of this study are to evaluate the efficacy, tolerability and pharmacokinetics
      of 2 doses of MAP0010 (Unit Dose Budesonide) in asthmatic children/adolescents.
    


Intervention name(s): MAP0010 low dose; MAP0010 high dose; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): a single dose of MAP0010 low dose delivered by nebulization twice daily for 6 weeks; a single dose of MAP0010 high dose delivered by nebulization twice daily for 6 weeks; Placebo delivered by nebulization twice daily for 6 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Combination Natural Health Product in Children With Attention Deficit/Hyperactivity Disorder (ADHD)
Condition: Attention Deficit Hyperactivity Disorder
MeSH terms: Hyperkinesis; Attention Deficit Disorder with Hyperactivity
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      Attention deficit/hyperactivity disorder (ADHD) is a chronic neurobehavioural disorder often
      diagnosed in childhood years. Complementary/alternative treatments including natural health
      products (NHPs) are used by children with ADHD despite limited information on their safety or
      usefulness. Some evidence suggests children with ADHD have a greater need for zinc,
      magnesium, vitamin B6 and vitamin C. This study will supplement a small number of children
      diagnosed with ADHD with therapeutic levels of these nutrients over 10 weeks to get a better
      understanding of the safety and possible benefit of using these nutrients to treat symptoms
      associated with ADHD.
    

Detailed description: 
      The is an open-label study. Children diagnosed with ADHD will be provided with a weight-based
      dose of a chewable natural health product containing zinc, magnesium, vitamin B6 and vitamin
      C for 10 weeks with an additional follow-up post intervention at 20 weeks. Severity of ADHD
      symptoms will be measured at baseline, week 5 and week 10 using the Connor-3 Parent and
      SNAP-IV validated questionnaires. Nutritional status will be monitored at baseline and week
      10 for changes in serum zinc and erythrocyte magnesium. Children will be monitored for any
      adverse reactions that may occur using the investigational product.Following the informed
      consent process, participants will undergo a structured psychiatric interview prior to
      enrollment and will have 4 30 minute study visits and 2 10 minute telephone calls throughout
      the study. Blood samples will be taken 2 times with the use of a topical anesthetic to
      decrease sensation during the blood draw. Once enrolled, children can withdraw from the study
      at any time if assent to participate is withdrawn.
    

Intervention name(s): Zinc, Magnesium, Vitamin B6, Vitamin C (Compound Natural Health Product for ADHD)
Intervention type(s): Dietary Supplement
Intervention description(s): Weight based dosing of a chewable natural health product containing 15-35 mg zinc citrate, 150-350 mg magnesium lactate, 30-70 mg pyridoxine hydrochloride and 150-350 mg calcium ascorbate. Participants will take weight based dose two times during the day with meals for a 10 week period
Other intervention name(s): Zinc; Magnesium; Vitamin B6; Vitamin C
Intervention MeSH terms: Vitamins; Ascorbic Acid; Vitamin B 6; Pyridoxal; Pyridoxine; Zinc; Vitamin B Complex
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Attention Deficit Disorder; Pediatrics; Attention; Impulsivity; Complementary Therapies
A Bioequivalence Study Comparing Amodiaquine Tablet (Pfizer) To Amodiaquine Tablets (Arsuamoon-Guilin China) In Healthy Subjects
Condition: Falciparum Malaria
MeSH terms: Malaria, Falciparum
Study type: Interventional
Phase: Phase 1

Summary: 
      The study will determine if amodiaquine tablet (Pfizer), an antimalaria agent, is
      pharmaceutically equivalent to a comparator product (Arsuamoon-Guilin China).
    


Intervention name(s): Amodiaquine (Test); Amodiaquine (Comparator)
Intervention type(s): Drug; Drug
Intervention description(s): Oral tablet, single dose, 1 X 300 MG; Oral tablet, single dose, 2 X 150 MG
Other intervention name(s): Camoquin; Camoquin
Intervention MeSH terms: Amodiaquine
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Bioequivalence, Healthy Volunteers