Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study
Condition: Pregnancy Complications
MeSH terms: Pregnancy Complications
Study type: Observational

Summary: 
      The maternity ward attached to the colposcopy clinic was also the obstetrical referral center
      for the region and carried out approximately 2500 deliveries per year. The aim of the study
      was to assess whether an age younger than 25 years at conization affected future pregnancy
      outcome as an independent factor. A retrospective study of 115 women who underwent both loop
      electrosurgical excision procedure (LEEP) and subsequent pregnancy follow-up in a referral
      center was conducted. Two groups were considered: patients younger than 25 years at the time
      of the loop electrosurgical excision procedure (n = 42) and 25 years or older (n = 73).
      Analyzed data were occurrence of preterm adverse obstetrical event and, specifically, preterm
      labor (PL) and preterm rupture of membranes; stratification based on term of occurrence was
      performed: less than 37 weeks of amenorrhea (WA), less than 34 WA, and less than 26 WA.
    

Detailed description: 
      The investigators conducted a retrospective observational study between January 2008 and
      December 2015 in a French colposcopic referral academic hospital. The maternity ward attached
      to the colposcopy clinic was also the obstetrical referral center for the region and carried
      out approximately 2500 deliveries per year. The aim of the study was to assess whether an age
      younger than 25 years at conization affected future pregnancy outcome as an independent
      factor. A retrospective study of 115 women who underwent both loop electrosurgical excision
      procedure (LEEP) and subsequent pregnancy follow-up in a referral center was conducted. Two
      groups were considered: patients younger than 25 years at the time of the loop
      electrosurgical excision procedure (n = 42) and 25 years or older (n = 73). Analyzed data
      were occurrence of preterm adverse obstetrical event and, specifically, preterm labor (PL)
      and preterm rupture of membranes; stratification based on term of occurrence was performed:
      less than 37 weeks of amenorrhea (WA), less than 34 WA, and less than 26 WA.
    

Intervention name(s): loop electrosurgical excision procedure
Intervention type(s): Other
Intervention description(s): A retrospective study of 115 women who underwent both loop electrosurgical excision procedure (LEEP) and subse- quent pregnancy follow-up in a referral center was conducted.
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        The investigators recruited all patients who underwent loop electrosurgical excision
        procedure during the studied period and subsequently delivered in our institution. This
        only concerned the immediate after pregnancy: patients having delivered in our institution
        after having delivered elsewhere after loop electrosurgical excision procedure were
        excluded. Early miscarriages (<14 weeks of amenor- rhea [WA]) were also excluded. All
        patients were managed according to a multidisciplinary decision, based on French guidelines
        at the time of diagnosis.
      
Keywords: LEEP; preterm labor