bioihbjkbjnl/mcl2 huggingface dataset:
Triamcinolone Assisted Anterior Vitrectomy
Condition: Vitrectomy; Cataract
MeSH terms: Cataract
Study type: Interventional
Phase: Phase 2

Summary: 
      Injecting Triamcinolone acetenoide for visualizing and removing vitreous from the anterior
      chamber.
    

Detailed description: 
      The research followed the tenets of the Declaration of Helsinki, ;informed consent were
      obtained from patients where all details of the procedure were explained with emphasis on the
      intended outcome. The research was approved by the institutional review board.

      Ten eyes of 10 patients were divided into 2 groups. Group A included 6 eyes of 6 patients
      with accidental rupture of posterior capsule during cataract surgery (5 eyes underwent
      phacoemulsification technique and one underwent ECCE). Group B included four eyes of 4
      patients undergoing anterior segment reconstruction (anterior vitrectomy, secondary IOL
      Implantation and iris repair by direct approximation using 10/0 prolene sutures). In group A
      the mean age was 68.1 ± 10.93 years (range 47 to 79 years), 3 were males and 3 were females.
      In group B the mean age was 14 ± 5.6 years (range 9 to 22 years), 3 were males and one
      female. Demographic data and pre-operative Information are presented in table 1 and 2.

      In all patients triamcinolone acetonide was prepared by keeping the bottle vertical to allow
      sedimentation of crystals thus removing the vehicle. It was then injected into the anterior
      chamber (2 ml with concentration 20 mg/ml) just prior to anterior vitrectomy. The direction
      of the tip of the needle was kept away from the corneal endothelium to minimize endothelial
      toxicity. Triamcinolone was removed as quickly & completely as possible after finishing
      anterior vitrectomy.

      Postoperative regimen included topical steroids and antibiotics for about 4-6 weeks. Topical
      anti-glaucoma drugs were used in cases of high postoperative IOP for few days until
      stabilization of IOP. Follow up period ranged from 2 months up to 27 months.
    

Intervention name(s): Intra ocular injection of triamcinolone acetonide
Intervention type(s): Drug
Intervention description(s): In all patients triamcinolone acetonide was prepared by keeping the bottle vertical to allow sedimentation of crystals thus removing the vehicle. It was then injected into the anterior chamber (2 ml with concentration 20 mg/ml) just prior to anterior vitrectomy. The direction of the tip of the needle was kept away from the corneal endothelium to minimize endothelial toxicity. Triamcinolone was removed as quickly & completely as possible after finishing anterior vitrectomy
Other intervention name(s): kena cort
Intervention MeSH terms: Triamcinolone; Triamcinolone Acetonide; Triamcinolone hexacetonide; Triamcinolone diacetate
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Triamcinolone acetenoide; anterior vitrectomy; presence of vitreous in the anterior chamber.; effect of triamcinolone injection on IOP,intraocular infection
Mirtazapine vs Sumatriptan in the Treatment of Postdural Puncture Headache
Condition: Headache
MeSH terms: Post-Dural Puncture Headache; Headache
Study type: Interventional
Phase: Phase 4

Summary: 
      Postdural puncture headache (PDPH) is a potential complication after spinal anesthesia caused
      by traction on pain-sensitive structures from low cerebrospinal fluid pressure (intracranial
      hypotension) following a leak of cerebrospinal fluid at the puncture site. Symptoms of this
      condition include a bilateral frontal or occipital headache that is worse in the upright
      position, along with nausea, neck pain, dizziness, visual changes, tinnitus, hearing loss, or
      radicular symptoms in the arms.

      This study will examine the efficacy of mirtazapine in in the treatment of PDPH after
      obstetric surgery under spinal anesthesia and compared its efficacy with that of sumatriptan.
    


Intervention name(s): Mirtazapine; Sumatriptan; Placebo
Intervention type(s): Drug; Drug; Other
Intervention description(s): Mirtazapine 30 mg tablet once daily for 3 successive days; Sumatriptan 50 mg tablet once daily for 3 successive days; Placebo tablets once daily for 3 successive days.
Intervention MeSH terms: Sumatriptan; Mirtazapine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Lower Limb Sclerotherapy of Reticular Veins and Telangiectasias
Condition: Telangiectasis
MeSH terms: Telangiectasis
Study type: Observational

Summary: 
      A long-term follow-up cohort study of patients that were assigned in two previous studies to
      compare the clinical results of sclerotherapy of telangiectasias and reticular veins of lower
      limbs using 0.2% polidocanol diluted in 70% hypertonic glucose (PDHG) vs 75% hypertonic
      glucose (HG) alone.

      All women, previously treated as aforementioned, were invited to be reevaluated regarding
      late maintenance and pigmentation over two years of follow-up.

      No new treatments were applied to the cohort.
    


Intervention name(s): Polidocanol 0,2% + Hypertonic Glucose 70% (PDHG)
Intervention type(s): Procedure
Intervention description(s): Patients previously treated were reassessed for long-term follow-up.
Other intervention name(s): Hypertonic Glucose 75% (HG)
Intervention MeSH terms: Polidocanol
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Women between 18 and 90 years, with lower limb telangiectasias or reticular veins treated
        in previous studies with polidocanol plus hypertonic glucose or hypertonic glucose.
      
Keywords: Sclerotherapy; Veins; Telangiectasias; Hyperpigmentation
The Utility of Breath Biopsy as a Screening Tool for HCC
Condition: HCC; Cirrhosis, Liver
MeSH terms: Liver Cirrhosis
Study type: Observational

Summary: 
      The aim of this pilot study is to examine whether there is a discriminating ability of the
      breath sample analysis to capture biomarkers specific to the HCC in the breath of affected
      individuals. If positive, our research could open up a new horizon for cost-effective and
      feasible screening tools.
    

Detailed description: 
      20 Participants will be included in the study. Ten Cirrhotic patients with HCC and 10
      Cirrhotic patients without HCC.

      The first group is patients with HCC secondary to cirrhosis. The second group will be
      patients with cirrhosis who are currently on the standard surveillance program with no HCC.
      Confirmation of the absence of HCC would have been ensured via a recent advanced imaging
      modality (dynamic CT scan or MRI) in the ongoing surveillance programme.

      Participants will breathe into either a mouthpiece or collection tube then Breath samples
      will be analyzed via an analyzer to detect the volatile organic compounds (VOC) and
      quantitatively compare them
    

Intervention name(s): Breath Biopsy
Intervention type(s): Diagnostic Test
Intervention description(s): Analysis of breath samples to identify volatile molecules specific to HCC
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The study is open for participants with liver Cirrhosis (without HCC allocated to an arm)
        and (with HCC allocated to the other arm). There is no gender restriction.
Characterize the Regional Distribution of [11C] ABP688 in Brain by Positron Emission Tomography (PET)
Condition: Depression
MeSH terms: Depression
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is designed to characterize the regional distribution of [11C] ABP688 in brain by
      positron emission tomography (PET).
    


Intervention name(s): ABP688
Intervention type(s): Drug
Intervention description(s): Carbon 11 labeled ABP688 will be administered intravenously as a slow intravenous push.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: ABP688; Tracer; Depression
Evaluation of the Performance of a Fungal Nail Treatment on the Visual Signs of Onychomycosis
Condition: Onychomycosis of Toenails
MeSH terms: Onychomycosis
Study type: Interventional

Summary: 
      This is a prospective, open label, non-comparative clinical investigation to evaluate the
      performance of a Fungal Nail Treatment on the visual signs of onychomycosis.

      The Fungal Nail Treatment is a CE Marked Class I Medical Device and is commercially available
      as an over-the-counter product.

      The ability of the Fungal Nail Treatment to treat the visual signs of mild fungal toenail
      infections will be determined by a reduction in the surface area of the infection over time.
      This will be assessed through visual quantification of the infected area from baseline, as
      measured by image analysis, throughout the treatment period, where subjects will follow
      instructions for use on the product pack and self-treat for the duration of the investigation
      or until their condition has resolved. Both subject and podiatrist will assess the
      improvement of signs and symptoms of the target nail.
    


Intervention name(s): A Fungal Nail Treatment
Intervention type(s): Device
Intervention description(s): treats the signs of mild fungal nail infections
Other intervention name(s): Funagl Nail Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Fungal Nail
Potato Consumption and Risk of Hypertension
Condition: Hypertension
MeSH terms: Hypertension
Study type: Observational

Summary: 
      Government has popularized potatoes as a major staple food in China. Potato, a potassium-rich
      food with high glycemic responses after consumption, exhibits unclear effects on
      hypertension. In this study, the investigators aimed to examine the association between
      potato consumption and hypertension risk among Chinese people.
    

Detailed description: 
      Potato is considered as a superior crop due to its significant nutritive value and great
      production yield. China is the largest potato producer with a quarter of world production,
      followed by India, Russia, and USA. The potato production as well as consumption has enhanced
      in developing countries while continuously declined in developed countries during the last
      decade. The investigators therefore explored the prospective associations of consumption of
      total potatoes, sweet potatoes, stir-fried potatoes, and non stir-fried potatoes with the
      risk of hypertension in general people of the China Health and Nutrition Survey (CHNS) cohort
      study from 1989 to 2011. A total of 11,763 participants (≥20 years old) who were free of
      hypertension at baseline were enrolled from CHNS Cohort study. Cox proportional hazards
      regression models were used to estimate the associations after adjusting for potential
      confounders. This study provides new evidence on the association of various potato
      consumption with the incidence of hypertension in China. As urbanization accelerates across
      the whole domain of China, the tendency of transition to Western-style diets and lifestyles
      appears continuously and steeply growing. More and more potatoes will be consumed as
      processed potato products including potatoes chips and French fries, which may be a potential
      risk factor of hypertension occurrence.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Of the 11,763 participants, 5,344 male and 6,419 female were enrolled, ranging from 20 to
        93 years old. People who consumed the potatoes, sweet potatoes, stir-fried potatoes, and
        non stir-fried potatoes accounted for 57.3%, 15.0%, 51.8%, and 28.1%, respectively. There
        were about 90.4% people who consumed the potatoes through the stir-frying method.
      
Keywords: potato consumption; hypertension; CHNS
Risperidone Pharmacokinetics in Children With Pervasive Developmental Disorder (PDD)
Condition: Child Development Disorders, Pervasive
MeSH terms: Developmental Disabilities; Autism Spectrum Disorder; Child Development Disorders, Pervasive
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this research is to study the pharmacokinetics of risperidone in a group of
      pediatric patients with Pervasive Developmental Disorder (PDD). The study will determine how
      much risperidone and its breakdown product, 9-hydroxy-risperidone, is in the blood following
      the patient's usual daily dose. The study is designed to look at how fast children absorb,
      breakdown, and eliminate risperidone.
    

Detailed description: 
      Pervasive Developmental Disorders is a category of disorders that includes autism and related
      conditions. While these disorders are rare, they represent a significant public health
      problem because they are extremely debilitating and lack efficacious therapies. Neuroleptic
      use in PDD is high and the population appears to be at increased risk of serious sequelae
      including tardive dyskinesia. Newer atypical neuroleptics including risperidone are now used
      in 87% of cases but dosing, safety and efficacy is undetermined in the vulnerable population.

      This study consists of a total of 3 visits, the initial screening visit where consent,
      medical history, demographics and vitals will be recorded. Two additional visits with blood
      sampling will occur. The second visit will be no greater than 30 days from the screening
      visit and the 3rd visit will be one month from Visit 2.
    

Intervention name(s): Risperidone
Intervention type(s): Drug
Intervention MeSH terms: Risperidone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Risperidone; Autism; PDD; Pervasive Developmental Disorder
Dermacyd Silver Floral (Lactic Acid) - Photo Evaluation
Condition: Hygiene
Study type: Interventional
Phase: Phase 3

Summary: 
      Primary Objective:

      To demonstrate the absence of photoirritation and potential photosensitization of the product
      Dermacyd Silver Floral.
    


Intervention name(s): LACTIC ACID(ND)
Intervention type(s): Drug
Intervention description(s): Dermacyd Silver Floral (Lactic Acid) sample will be applied like a curative during 5 weeks (treatment period).
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Oxytocin for Couples Conflict Resolution
Condition: Substance Misuse; Interpersonal Conflict; Neuroendocrine Reactivity
Study type: Interventional
Phase: Phase 2

Summary: 
      Oxytocin is a promising new medication found to have positive effects on prosocial behavior,
      reduce negative affect such as fear and anxiety, and reduce stress-induced addictive
      behaviors. This study aims to investigate the extent to which a 40 IU dose of intranasal
      oxytocin improves couples' conflict resolution skills and subjective, physiological, and
      neuroendocrine responses to conflict. Conflict resolution discussions will take place in the
      laboratory and will be videotaped.
    

Detailed description: 
      Substance use disorders (SUD) are characterized by dysregulation of the
      hypothalamic-pituitary axis (HPA). The neuropeptide oxytocin, commonly administered as an
      intranasal spray, is a drug that has prominent anxiolytic and prosocial effects on human
      behaviors. While the mechanisms of action facilitating the behavioral effects of oxytocin in
      humans is complex and many questions about this process remain, there is a consensus in the
      existing literature that oxytocin modulates HPA axis reactivity to stressful social stimuli.
      Preliminary studies suggest that oxytocin is known to reduce couple conflict among normative
      couples. A more developed line of research indicates that oxytocin mitigates addictive
      behaviors in the context of various drugs of abuse. Given the high prevalence and severity of
      dyadic conflict among couples where one or both partner has substance abuse, and given the
      salience of dyadic conflict as a precipitant to substance use behaviors, it is critical to
      investigate the therapeutic effects of oxytocin among couples with substance use problems.
      Namely, oxytocin holds promise as a potential augmenter for conjoint couples therapies,
      particularly those targeting the reduction of substance use problems. However, only two
      studies have examined the effects of oxytocin on couples' communication behaviors. Those two
      studies found that couples' communication skills improved following the administration of
      oxytocin. It is important to extend this line of research to examine conflict resolution
      skills among couples with substance use problems. To date, no studies have examined the
      effects of oxytocin on subjective, physiological, or neuroendocrine reactivity to dyadic
      conflict. The present study aims to fill that gap in the literature.
    

Intervention name(s): Oxytocin; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Placebo for Oxytocin
Other intervention name(s): Pitocin
Intervention MeSH terms: Oxytocin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Other
Trial of Vitamin D3 Supplementation in Paediatric Autism
Condition: Autism
MeSH terms: Autistic Disorder
Study type: Interventional

Summary: 
      To build on a recent case study and open label trial, the investigators want to find out if
      vitamin D supplementation can influence behavioural and core symptoms of autism.
    

Detailed description: 
      The investigators will assess behavioural and core symptoms of autism before and after 20
      weeks of vitamin D supplementation in a double-blind, placebo-controlled trial.
    

Intervention name(s): Vitamin D3; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 2,000iu vitamin D drops will be taken daily for 20 weeks; Matching placebo drops will be taken daily for 20 weeks
Other intervention name(s): cholecalciferol
Intervention MeSH terms: Vitamin D; Cholecalciferol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Afamelanotide in Patients Suffering With Acne Vulgaris
Condition: Acne Vulgaris
MeSH terms: Acne Vulgaris
Study type: Interventional
Phase: Phase 2

Summary: 
      This study aims to evaluate the effect of afamelanotide on the facial inflammatory
      acne-related lesions in patients with mild to moderate acne vulgaris, including tolerability
      of afamelanotide by patients with moderate acne vulgaris and effects of the treatment on
      quality of life in eligible patients.
    


Intervention name(s): Afamelanotide
Intervention type(s): Drug
Intervention description(s): Group A is administered afamelanotide implant on Days 0, 21 and 42; Group B is administered afamelanotide implant on Days 0 and 28.
Intervention MeSH terms: Afamelanotide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Postpartum Etonogestrel Implant for Adolescents
Condition: Adolescence; Contraception; Postpartum
Study type: Interventional
Phase: Phase 4

Summary: 
      This is a prospective study comparing two groups of 48 adolescent women each. The
      intervention group will receive a contraceptive implant postpartum, prior to discharge from
      the hospital. The control group will receive a contraceptive implant at the usual 6 week
      postpartum clinic visit. During prenatal care, participants will be consented and screened
      for enrollment. After delivery, these women will be assessed and consented for enrollment
      into the study. Women who consent for enrollment will be randomized. Women will be followed
      up at 3 months, 6 months, 9 months, and 1 year after contraceptive implant insertion. At each
      follow up, women will be assessed for continuation of and satisfaction with this method of
      contraception.
    


Intervention name(s): Contraceptive implant
Intervention type(s): Drug
Other intervention name(s): Implanon, Nexplanon, etonogestrel contraceptive implant
Intervention MeSH terms: Contraceptive Agents; Etonogestrel
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: adolescence; contraception; postpartum; rapid repeat pregnancy
Safety and Efficacy Challenge Study of Live Oral Cholera Vaccine Candidate,PXVX0200, to Prevent Cholera
Condition: Cholera
MeSH terms: Cholera
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of the study is to determine if PXVX0200 is safe and effective in preventing
      cholera infection
    

Detailed description: 
      A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Efficacy Trial of a Single Dose of
      Live Oral Cholera Vaccine Candidate, PXVX0200 CVD 103-HgR Strain, in Preventing Cholera
      following Challenge with Vibrio cholerae O1 El Tor Inaba 10 Days or 3 Months after
      Vaccination in volunteers aged 18-45 years
    

Intervention name(s): PXVX0200; placebo
Intervention type(s): Biological; Biological
Intervention description(s): Single dose; liquid suspension after reconstitution with buffer; 5x10^8
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention