bioihbjkbjnl/mcl2 huggingface dataset:
Bone Density and Marginal Bone Height Changes Around Dental Implants
Condition: Implant Site Reaction
Study type: Interventional

Summary: 
      The increased benefits to the edentulous population from implant supported overdenture is
      overwhelming in terms of better quality of life, emotional stability, improved function,
      enhanced esthetics and clinical comfort.1-6 Implant supported prosthesis is considered a
      viable option for partially edentulous patients7. The oral rehabilitation of a long anterior
      mandibular edentulous span with a fixed or removable implant-supported prosthesis using
      appropriate prostheses have been a target in oral implant research for the last year. The
      longevity of any implant prosthesis depends on successful osseointegration and implant
      stability. Cone beam computed tomography (CBCT ) has also been used extensively for the
      follow-up of dental implants and is considered one of the tools for assessing implant success
    

Detailed description: 
      This study will be conducted on 6 patients having mandibula Kennedy Class VI (anterior
      edentulous span) Each patient will receive 5 dental implants in the interforaminal area. The
      patients will be randomly categorized into two groups. According to the final restoration
      they will receive.

      Group I: will receive a digital milled implant supported overdenture. While Group II will
      receive implant supported fixed bridge.

      The marginal bone height changes and bone density around the dental implants will be
      evaluated at the time of prosthesis insertion, after one and three month.

      Research Procedures:

        1. Patient selection: will be following inclusion and exclusion criteria.

        2. 5 implants will be installed in the interforaminal area for each patient.

        3. Digital impression, bite registration, try in and delivery of the final prosthesis for
           each group will follow the conventional methods.

        4. The marginal bone height changes and bone density around the dental implants using CBCT
           will be evaluated at the time of prosthesis insertion, after one and three month.

        5. Statistical analysis: Data will be collected, tabulated, and statistically analyzed
           using Microsoft Excel ® 2016, Statistical Package for Social Science (SPSS)® Ver. 24.
           and Minitab ® statistical software Ver. 16.
    

Intervention name(s): Dental implants.
Intervention type(s): Procedure
Intervention description(s): 5 conventional implants measuring from 4 to 5 mm in width and 7 to 10mm in length according to the bone width were inserted in the mandible from right premolar area to left premolar area
Other intervention name(s): OXY implants
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: digital milled partial overdenture; Bone density; Fixed bridge
Mechanism Based Resistance to Aspirin
Condition: Aspirin Resistance; Pharmacological Aspirin Non-responsiveness
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this research is to study why some people do not respond to the benefits of
      aspirin therapy. The benefit of aspirin is cardioprotection, or decreasing the risk of heart
      attack and/or stroke. Aspirin works by disabling the platelets, part of the blood cells used
      in clotting, from sticking together and forming blood clots, thus protecting the heart. It
      has been observed that failure to respond to aspirin therapy occurs in about 10% of the
      general population and that despite taking aspirin everyday, this group of non- responders is
      not getting protection for their heart. The investigators would like to determine why and how
      this happens.
    


Intervention name(s): Aspirin
Intervention type(s): Drug
Intervention description(s): 325 mg enteric coated single dose p.o.
Intervention MeSH terms: Aspirin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: aspirin resistance; cardiovascular risk; prostaglandins; platelet inhibition
Cell Biology of Steroid Resistant Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional

Summary: 
      The hypothesis is that patients who demonstrate steroid resistant asthma by showing little or
      no improvement in lung function after a course of oral steroids have different cellular
      responses to steroids than patients who are steroid sensitive. These altered responses are
      the reason they demonstrate steroid resistance.
    

Detailed description: 
      Current NHLBI guidelines for persistent asthma management recommends the use of steroids for
      treatment of airway inflammation (1,2). However, some asthmatics do not respond to steroids
      (3-6). Unfortunately these patients are subjected to the unwanted side effects (osteoporosis,
      cataracts, etc) of high dose steroid therapy because non-immune tissues remain sensitive to
      steroids. Recent studies suggest that the costs of asthma are largely attributable to
      uncontrolled disease (7). Thus, it is important to understand the mechanism(s) of steroid
      resistance and introduce new forms of therapy for the treatment of these difficult to control
      asthmatics. As a prelude to pharmaceutical studies in steroid resistant asthma, it is
      imperative to develop biomarkers that can robustly identify individuals likely to be poor
      steroid responders so that alternative non-steroid anti-inflammatory therapies, such as
      Xolair®, can be introduced early in the course of asthma therapy.
    

Intervention name(s): prednisone
Intervention type(s): Drug
Intervention MeSH terms: Prednisone
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: steroid resistant asthma
Popcorn Lung: the Discovery of a New Disease
Condition: Lung Diseases, Interstitial; Bronchiolitis Obliterans
MeSH terms: Bronchiolitis; Lung Diseases; Bronchiolitis Obliterans; Bronchiolitis Obliterans Syndrome; Lung Diseases, Interstitial
Study type: Observational

Summary: 
      Recently, an epidemic of pulmonary disease has been recognized among workers in a popcorn
      factory in Jasper, Missouri. The exposure agent has not yet been identified, but suspects
      include butter flavoring and the powdered salt used in the mixing room. This disease
      resembles "Bronchiolitis Obliterans Syndrome", an illness that makes it difficult to breathe.
      Of the 117 workers studied, one year later, 25 subjects whom were working in the mixing room
      or in the microwave packaging area have had decreases in lung function seven times the norm
      for their age. Industrial hygiene experts revealed that dust concentrations of salt and other
      flavorings were much higher in the mixing room compared to the office and outdoor work areas.
      Recently, rats were exposed to vapors created by heating the butter flavor compound obtained
      from this plant. Six-hour exposure to vapors at very high concentration resulted in
      significant damage to the breathing apparatus. Thus, there is clinical, epidemiological, and
      animal toxicity data that appears to implicate some constituent present during the mixing of
      the butter flavoring, salt, and oil causing a form of obstructive airway disease that has
      been rapidly progressive in a number of workers. It is not clear what the pathophysiologic
      nature of this entity is, though it resembles Bronchiolitis Obliterans Syndrome. It is not
      known what the long term consequence of this will be on the active workers, nor is it clear
      whether preventive measures taken to reduce exposures in the mixing room and elsewhere in the
      plant are going to be effective.
    


Observational model: Defined Population
Time perspective: Other
Immunogenicity and Safety Study of 1 and 2 Doses of GlaxoSmithKline (GSK) Biologicals' Meningococcal Vaccine MenACWY-TT (GSK134612) in Toddlers, Persistence up to 5 Years After Vaccination and Co-administration With Pfizer's Prevenar 13™Vaccine
Condition: Infections, Meningococcal
MeSH terms: Meningococcal Infections
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to compare the immediate and long term (up to 5 years)
      immunogenicity and safety of GSK Biologicals' MenACWY-TT vaccine when given as a single dose
      or as 2 doses to toddlers aged 12 to 14 months. Also, this study will also assess if
      co-administration of GSK Biologicals' MenACWY-TT with the booster dose of Pfizer's Prevenar
      13 adversely impacts the immunogenicity of either of the vaccines.
    

Detailed description: 
      The Medicines Control Council (MCC) authorities requested that subjects be screened for HIV
      testing prior to study enrolment in South Africa to ensure that only HIV negative
      participants are enrolled. As such, HIV rapid test was added at Visit 1 only for subjects in
      South Africa. Subjects previously screened HIV positive will be excluded.
    

Intervention name(s): Meningococcal vaccine GSK134612; Prevenar 13™
Intervention type(s): Biological; Biological
Intervention description(s): 1 or 2 doses administered intramuscularly in the left anterolateral thigh or deltoid region; 1 dose administered intramuscularly in the right anterolateral thigh or deltoid region
Intervention MeSH terms: Heptavalent Pneumococcal Conjugate Vaccine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Co-administration; Safety; Persistence; Immunogenicity; Prevenar 13; Meningococcal vaccine; Toddlers; 5 years
Study of a Treatment Driven by Early PET Response to a Treatment Not Monitored by Early PET in Patients With AA Stage 3-4 or 2B HL
Condition: Hodgkin's Lymphoma
MeSH terms: Lymphoma; Hodgkin Disease
Study type: Interventional
Phase: Phase 3

Summary: 
      All study treatments have proven efficacy in the treatment in Hodgkin lymphoma (HL). It is
      hoped that patients will achieve a good response to both induction therapies consisting
      either of 4 cycles of BEACOPPesc (Bleomycin, Etoposide, Doxorubicin, Cyclophosphamide,
      Vincristine, Procarbazine, and Prednisone) or 2 cycles of BEACOPPesc plus 2 cycles of ABVD
      (Adriamycine, Bléomycine, Vinblastine, Décarbazine).

      The use of F-FDG Position Emission Tomography performed after 2 cycles of chemotherapy (PET2)
      in the experimental arm will help to stratify patients in order to restrict the BEACOPPesc
      therapy continuation to those patients who achieved only a partial response after 2
      BEACOPPesc regimen and to allow a conventional dose ABVD chemotherapy strategy for PET2
      negative patients. For all patients included in the trial the achievement of a good response
      to induction treatment will be checked after four cycles of induction treatment including a
      centrally reviewed PET assessment

      Patients will be randomized after verification of eligibility and before the start of the
      protocol treatment.Patients will be randomly assigned to the standard treatment arm not
      monitored by early PET, or the experimental treatment arm driven by the PET2 result.
    


Intervention name(s): BEACOPPesc; BEACOPPesc - ABVD - PET2
Intervention type(s): Drug; Drug
Allocation: Randomized
Intervention model: Parallel Assignment
How Does Eating Behavior and Hunger in Virtual Reality Meals Compare to Real Meals?
Condition: Hunger
Study type: Interventional

Summary: 
      Objective: To investigate the differences between eating virtual and real-life meals and test
      the hypothesis that eating a virtual meal can reduce hunger among healthy women.

      Methods: Twenty healthy women will be recruited and partake in a randomized crossover study.
      The subjects will be asked to eat one introduction meal, two real meals, and two virtual
      meals, all containing real or virtual meatballs and potatoes. The real meals will be eaten on
      a plate placed on a scale which communicates with analytical software on a computer. The
      virtual meals will be eaten in a room, where participants are seated on a real chair in front
      of a real table, and fitted with the virtual-reality equipment. The eating behavior for both
      the real and virtual meals will be filmed. Hunger will be measured before and after the meals
      using questionnaires.
    


Intervention name(s): Virtual food; Real food
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Virtual food eaten using immersive virtual reality equipment; Real food eaten using regular utensils
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Randomized crossover study with 2 repeats. Each person participated in two virtual meals and two real meals in random order.
Masking: None (Open Label)
Primary purpose: Basic Science
Effectiveness of Smartphone Application for Weight Loss
Condition: Weight Loss
MeSH terms: Body Weight; Weight Loss
Study type: Interventional

Summary: 
      The aim of this study is

      To determine the effectiveness of smartphone application for weight loss in healthy female
      adults.

      To determine the association between fitness application usage and physical activity behavior
      of the healthy female adults.
    

Detailed description: 
      Obesity has turned into a significant, rising well-being epidemic around the world. Doing
      almost no physical work has been connected with chronic weakness results and diminished
      personal satisfaction in adulthood. It has been perceived that innovation can uphold
      wellbeing upgrades around the world. The applications that target wellbeing advancement have
      turned into a focal piece of individuals' lives and have exhibited enormous expansions being
      used. Proper evidence behind usage of smart phone application for weight loss is sparse and
      is based on different clinical experiences and a smaller number of studies with limited
      methodological design. This study will contribute to describing the effectiveness of
      smartphone application for weight loss in female adults as well as to determine the
      association between fitness application usage and physical activity behavior.
    

Intervention name(s): MyNetDiary app group; Paper diary group
Intervention type(s): Other; Other
Intervention description(s): MyNetDiary will be used to track calories, and exercise while motivating for living a healthier life each day.The intervention period would last for three months. Total energy expenditure (TEE) of every participant enrolled into the study would be calculated at the start of the study and an exercise and diet plan with a calorie deficit of around 1000 kcal per week would be provided to the participant. The diet and exercise plan would be modified according to the new TEE of the participant. MyNetDiary app has built-in food and exercise activities with their respective calories' count. Moreover, customized foods and exercises can also be added into the application; Paper Diary will be used to track calories and exercise. The nutritional intake and exercise would be recorded for three months. The diet and exercise plans would be modified according to the new Total Energy Expenditure of the participants.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Adult Females; Exercise Adherence; Obesity; Physical Activity; VO2 Max; Weight Loss
Preoperative Transcranial Doppler as a Predictor for Delirium Following On-pump Cardiac Surgery
Condition: Postoperative Delirium After On-pump Cardiac Surgery
MeSH terms: Delirium; Emergence Delirium
Study type: Observational

Summary: 
      Postoperative delirium is an important problem in patients undergoing major cardiac surgery
      and associated with more complicated hospital course, increased hospital length of stay and
      total postoperative cost. A study shows that a low preoperative cerebral oximetry (rSO2) is
      associated with postoperative delirium after on-pump cardiac surgery. Another study showed
      that patients who underwent cardiac surgery with reduced cerebral blood flow (CBF) velocity
      in the left middle cerebral artery (MCA) preoperatively are at greater risk for postoperative
      cognitive dysfunction (POCD). Therefore, the investigators hypothesize that lower
      perioperative rSO2 and reduced preoperative mean flow velocity (MFV) of MCA are good
      predictors of the postoperative delirium in the patients undergoing the on-pump cardiac
      surgery.
    


Intervention name(s): No actual intervention
Intervention type(s): Other
Intervention description(s): Contact with enrolled subjects requires application of ceberal oximetry electrodes and the preoperative ultrasound (transcranial doppler) of the both MCA. No actual intervention done to subject.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        patients undergoing on-pump cardiac surgery
      
Keywords: postoperative delirium; on-pump cardiac surgery; cerebral oximetry; cerebral blood flow velosity
Assess Efficacy, Immune Response & Safety of 2 Doses of Oral Live Attenuated HRV Vaccine in Healthy Infants
Condition: Infections, Rotavirus
MeSH terms: Rotavirus Infections
Study type: Interventional
Phase: Phase 2

Summary: 
      To assess the efficacy, immune response and safety of the oral live attenuated HRV vaccine
      (Rotarix) in healthy infants approximately 2 months of age and previously uninfected with
      human rotavirus
    


Intervention name(s): Rotarix
Intervention type(s): Biological
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Prevention
Keywords: Oral live attenuated human rotavirus vaccine; Gastroenteritis
Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis
Condition: Arthritis
MeSH terms: Arthritis; Arthritis, Juvenile
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this research study is to see if patients with juvenile idiopathic arthritis
      or seronegative arthritis (and related conditions) mount protective immune responses to the
      human papillomavirus (HPV) vaccine called Gardasil. The researchers also want to monitor for
      any increase in disease activity following receipt of the vaccine.
    

Detailed description: 
      Each individual subject's participation is scheduled to last approximately two years.
      Patients will be given Gardasil injections at months 0, 2, and 6. Patients will have
      geometric mean titers (GMT) measured at 7, 12, and 24 months. Questionnaires about health and
      function will also be completed at each visit.
    

Intervention name(s): Blood Draws for Serum Titers
Intervention type(s): Other
Intervention description(s): All study subjects are receiving the Gardasil vaccine as part of their clinical care. The Gardasil vaccine is not given because of study participation. The study observes outcomes related to this clinical care. Study intervention consists of some blood samples taken to measure antibody and RNA titers. Other study specific procedures performed include Questionnaires and observational data.
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Intervention model description: Open label vaccination study Gardasil vaccine (4 component).
Masking: Single (Outcomes Assessor)
Primary purpose: Other
Keywords: JIA; SEA syndrome; AS; psoriatic arthritis; HPV vaccine
Pharmacokinetics of Single and Multiple Oral Doses of BI 1356 in Healthy Chinese Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      Study to investigate the pharmacokinetics of BI 1356 after single and multiple oral doses of
      5 mg in Chinese healthy subjects
    


Intervention name(s): BI 1356 BS; BI 1356 BS
Intervention type(s): Drug; Drug
Intervention description(s): single dose; multiple doses
Intervention MeSH terms: Linagliptin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Study of Efficacy, Safety and Tolerability of CMK389 in Patients With Chronic Pulmonary Sarcoidosis
Condition: Pulmonary Sarcoidosis
MeSH terms: Sarcoidosis, Pulmonary; Sarcoidosis
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this proof of concept study is to determine whether CMK389 displays the safety
      and efficacy profile to support further development in chronic pulmonary sarcoidosis.
    


Intervention name(s): CMK389; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): single i.v. dose every 4 weeks; single i.v. dose every 4 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants will be assigned to one of two treatment arms, either CMK389 or placebo.
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: chronic pulmonary sarcoidosis
Polyherbal Capsule Formulation for Joint Health
Condition: Knee Discomfort; Pain Physical Activity
Study type: Interventional
Phase: Phase 4

Summary: 
      This is a multicenter, randomized, double-blind, placebo-controlled, study in subjects with
      exercise-related knee pain/discomfort to determine the efficacy of a polyherbal capsule
      compared to placebo capsule in improving exercise capacity and overall parameters of joint
      health.
    

Detailed description: 
      Subjects will come to the study site at Visit 1 for screening assessments (which will occur
      within 14 days before the start of the run-in period) and to answer questions associated with
      habitual diet, exercise capacity, and level of activity. Those subjects who meet initial
      inclusion/exclusion criteria will undergo a run-in period of at least 7 days at home to
      discontinue use of all concurrent dietary supplements. Subjects will then return to the study
      site at Visit 2 (Baseline; Day 0) for further assessments and those meeting all
      inclusion/exclusion criteria will be enrolled into the study and randomly assigned to study
      product.

      Approximately 108 subjects (54 per treatment group) will be enrolled in the study. Subjects
      will be evaluated at Visit 3 (Day 14), Visit 4 (Day 45), Visit 5 (Day 60, phone call), and
      Visit 6 (Day 90). Exercise capacity (ie, 6-minute timed walk distance test) will be assessed,
      along with overall knee wellness and joint-related symptoms using WOMAC, PGA, Knee Pain
      Rating Scale, and rescue medication usage. Safety will be assessed by collecting adverse
      events (AEs) and clinical laboratory data.
    

Intervention name(s): Polyherbal capsule; Placebo capsule
Intervention type(s): Dietary Supplement; Dietary Supplement
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Basic Science
Keywords: Dietary herbs; Polyherbal capsule; Functional exercise capacity; Joint health