bioihbjkbjnl/mcl2 huggingface dataset:
The Use of Corticotomy for Upper Incisors Retraction
Condition: Class II Division 1 Malocclusion
MeSH terms: Malocclusion
Study type: Interventional

Summary: 
      We aim to assess the treatment outcomes following upper incisors retraction accelerated by
      corticotomy procedure. So, we intend to randomize orthodontic patients with class II division
      I malocclusion into two groups: experimental group and control group. Both groups will start
      orthodontic treatment. Once a 0.019*0.025-inch stainless steel wire is fully engaged to the
      brackets, 1st premolars will be extracted. Canines will be retracted in the conventional
      manner. Then, the actual evaluation period starts when the upper incisors are retracted using
      two different methods.
    

Detailed description: 
      In the last three decades, the number of adult patients seeking short orthodontic treatment
      time has apparently increased as the conventional orthodontic treatment usually lasts for
      20-24 months. Furthermore, orthodontic treatment is often associated with root resorption,
      bone degradation and caries development. Patients nowadays desire to end the orthodontic
      treatment as soon as possible due to phsycosocial reasons and to get the goals of the
      treatment without affecting their social life .

      So many tooth movement accelerating methods have been proposed. However, the surgical
      approached are considered the most effective and promising methods in accelerating tooth
      movement. The current research aims to evaluate the efficacy of the a new proposed surgical
      method compared to the conventional method in upper incisors' retraction.
    

Intervention name(s): Corticotomy-assisted Retraction
Intervention type(s): Procedure
Intervention description(s): Using a tunneling technique, the researcher will perform the intervention in the alveolar bone surrounding the upper incisors before retraction.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Is a Knee Arthroscopy of Any Benefit for the Middleaged Patient With Meniscal Symptoms?
Condition: Chronic Meniscus Injury
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether a knee arthroscopy is effective in the
      treatment of middleaged patients with meniscal symptoms also receiving a standardised
      exercise program.
    

Detailed description: 
      There are no studies proving a significant positive effect of a knee arthroscopy in
      middleaged patients with meniscal symptoms in excess of a structured rehabilitation program.
      In this study consecutive patients aged 45-64 years referred to the orthopaedic department at
      the University hospital Linköping for a suspected meniscal injury will be randomised to a
      rehabilitation program or a knee arthroscopy + the same rehabilitation program. Functional
      tests will be performed by a physiotherapist. There will be patient administrated
      questionaries sent out after 3 and 12 month.
    

Intervention name(s): Knee arthroscopy
Intervention type(s): Procedure
Intervention description(s): Knee arthroscopy within 4 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Meniscal injury; Knee arthroscopy; Middleaged; Functional outcome
B-HCG Levels in Women Diagnosed With Retained Products of Conception
Condition: Retained Products of Conception
Study type: Observational

Summary: 
      Retained Products of Conception (RPOC) is a condition where gestational tissue remains in the
      uterus after birth or after a surgical or medical abortion. This condition may cause
      significant bleeding, infection, and long-term intrauterine adhesions associated with
      fertility problems and pregnancy complications (Asherman's syndrome). RPOC are diagnosed
      according to the clinical and ultrasound findings (such as an echogenic foci in the uterine
      cavity with Doppler blood flows). However, the diagnosis of RPOC by clinic and ultrasound
      characteristics is inaccurate and false positive results are reported in up to 40% of women
      undergoing a surgical procedure for RPOC removal (most often by hysterosocpy). However,
      surgery also carries a risk of complications and intrauterine infections. Therefore, the need
      arises for additional tools to improve the diagnosis available today in order to minimize the
      need for surgical procedures as much as possible.

      The production and secretion of the B-HCG occurs in the placenta and begins after blastocyst
      implantation. The B-HCG levels increase in other placental pathologies such as gestational
      trophoblastic disease (GTD). Accordingly, the investigators hypothesized that in cases of
      placental remnants a secretion of B-HCG may be detected and quantified.

      In this prospective, non-interventional study the investigators' aim is to examine whether
      B-HCG can be used as a marker for detecting placental remnants, compared to the currently
      accepted sonographic method. For this purpose, the investigators will examine the levels of
      B-HCG in participants undergoing hysteroscopy for removal of RPOC.
    


Intervention name(s): Plasma B-HCG levels
Intervention type(s): Diagnostic Test
Intervention description(s): Blood sample
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Women >18 years admitted for hysteroscopy for RPOC removal following delivery of abortion.
      
Keywords: Hysteroscopy; Ultrasound
A Study to Evaluate the Efficacy and Safety of Zingo in Chinese Children
Condition: Catheter Site Pain; Pain, Acute; Anesthesia, Local
MeSH terms: Acute Pain
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of the study is to evaluate the efficacy and safety of Zingo in treating pain
      associated with venipunture and peripheral venous cannulation.
    


Intervention name(s): Lidocaine (Zingo); Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 0.5 mg lidocaine, 20 bar pressure; Placebo injector, 20 Bar pressure, empty injector
Other intervention name(s): Zingo
Intervention MeSH terms: Lidocaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Desipramine for Improving Cellular Signaling and Decreasing Symptoms of Major Depression
Condition: Depression
MeSH terms: Depression; Depressive Disorder
Study type: Interventional
Phase: Phase 4

Summary: 
      This study will determine the effectiveness of desipramine in improving cellular signaling,
      and thereby decreasing symptoms of depression in people with major depressive disorder (MDD).
    

Detailed description: 
      MDD is a serious mental illness that can interfere with a person's ability to eat, sleep,
      work, and enjoy activities that were once pleasurable. It is characterized by several
      symptoms, including as the following: persistent sad, anxious, or "empty" mood; feelings of
      hopelessness or pessimism; and feelings of guilt, worthlessness, or helplessness. The
      receptor-G protein-adenylate cyclase enzyme complex (AC enzyme complex) is a major cell
      signaling system in the brain, blood, and other tissues in the body. Changes in this
      signaling system among blood cells have been observed in people with major depressive
      disorder. Research has shown that treatment with the benzodiazepine alprazolam corrects the
      signaling problem, and thereby improves symptoms of MDD. This study will determine whether
      impairments in the AC enzyme complex exist among depressed individuals. This study will also
      evaluate the effectiveness of desipramine, an antidepressant, in improving blood cell
      signaling, and thereby decreasing symptoms of depression in people with major depressive
      disorder.

      Both healthy and depressed participants will be recruited for this study. All depressed
      participants in this study will first be assessed for depression severity using the Hamilton
      Depression Rating Scale. If eligible for the study, participants will be examined to
      determine AC enzyme complex functioning in both platelets and mononuclear leukocytes. A
      cohort of the depressed participants will be treated with desipramine. They will be examined
      to determine the drug's effect on AC enzyme complex functioning, as well as its effect on MDD
      symptoms, at Weeks 1, 4, and 6.
    

Intervention name(s): Desipramine
Intervention type(s): Drug
Intervention MeSH terms: Desipramine
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Major Depressive Disorder; MDD
A Chronic Obstructive Pulmonary Disease (COPD) Trial Investigating Roflumilast on Safety and Effectiveness in China, Hong Kong and Singapore:
Condition: COPD
Study type: Interventional
Phase: Phase 3

Summary: 
      The aim of this trial is to determine the efficacy, safety and tolerability of 500 µg
      Roflumilast tablets once daily in patients with COPD in China, Hong Kong, and Singapore.
    


Intervention name(s): Roflumilast; Placebo; Salbutamol
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Roflumilast tablets; Placebo tablets; Salbutamol (given by MDI and spacer) used as rescue medication on an ass needed basis throughout the trial, and was used for post-bronchodilator spirometry tests at all study visits.
Intervention MeSH terms: Albuterol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: COPD; Roflumilast; FEV1; China
EYE-TRAC Advance: Technology Verification (ETA-TV) Cohort 1
Condition: Eye-tracking
Study type: Interventional

Summary: 
      This study will assess the effects of exercise and non-concussive bodily contact on
      eye-tracking scores collected by the EYE-SYNC eye-tracking device.
    

Detailed description: 
      The investigators propose to prospectively study a cohort of 18-25-year-old athletes.
      Athletes will be tested with the EYE-SYNC eye-tracking device prior to the start of an
      athletic practice or competition (pre-test) and then after the conclusion of the
      practice/competition (post-test). The investigators hope to understand if eye-tracking scores
      are effected by exercise and non-concussive bodily contact commonly incurred during athletic
      play.
    

Intervention name(s): EYE-SYNC eye-tracking device; SCAT-3; Desktop Eye-Tracker
Intervention type(s): Device; Other; Device
Intervention description(s): The EYE-SYNC® portable eye-tracking system. The eye tracker is a handheld isolated display environment with embedded eye tracking sensors. The eye tracker is connected to a high-performance Windows tablet though a customized docking station. Included accessories with EYE-SYNC are a U.S. tablet power supply adapter and disposable sanitary masks. Participants are asked to follow a dot with their eyes, as the dot moves on the screen of the EYE-SYNC device.; The Symptom subtest of SCAT-3 assessment tool will be administered to participants.; Eye movements are recorded with an eye tracking system (Desktop Eye-Tracker, Eyelink CR, SR Research) with up to 1000 Hz temporal resolution. The target stimulus is presented on a computer screen approximately 50 cm from the participant. Participants are asked to follow a dot with their eyes, as the dot moves on the monitor screen of the desk-top eye-tracking device.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: concussion, eye-tracking, athletes, vision
Resistance and/or Endurance Training, What is Most Effective in Prevention of Cardiovascular Diseases?
Condition: Metabolic Syndrome
MeSH terms: Metabolic Syndrome; Syndrome
Study type: Interventional

Summary: 
      The aim of the present study was to evaluate the effects of aerobic interval training versus
      strength training or a combination of these regimes on factors comprising the metabolic
      syndrome in order to find the most effective exercise regime for patients with metabolic
      syndrome.
    

Detailed description: 
      In the Western world, approximately 25% of young to middle-aged adults have metabolic
      syndrome. There seem to be a strong age-dependence in the prevalence of the metabolic
      syndrome, but the incidence rises rapidly within adolescents and middle-aged groups and
      follows the development of obesity in the general population. Metabolic syndrome confers an
      increased risk of coronary heart disease, cardiovascular disease, and premature death;
      therefore, effective and affordable strategies to combat the syndrome would be of great
      individual and social importance.

      Despite the general agreement that moderate-intensity physical activity for a minimum of 30
      min five days per week or vigorous-intensity aerobic physical activity for a minimum of 20
      min three days a week promote and maintain health, the optimal training regime to treat
      metabolic syndrome and its associated cardiovascular abnormalities remains uncertain.
    

Intervention name(s): aerobic exercise; strength training
Intervention type(s): Behavioral; Behavioral
Intervention description(s): carried out 3 times per week for 12 weeks; carried out 3 times per week for 12 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Exercise therapy
Prevention of Healthcare Associated Infections in Bone Marrow Transplant Patients
Condition: Transplantation Infection
MeSH terms: Infections; Communicable Diseases; Cross Infection
Study type: Interventional

Summary: 
      This study involves sampling bone marrow transplant patients, hospital workers and the
      patient room for microbes using swabs and other techniques. We send these samples to the
      laboratory, where they will use state-of-the art technology to identify and relate the
      microbes to each other. This study also involves putting copper, nickel, or titanium into
      some hospital rooms, and seeing whether these metals influences the growth of microbes. Some
      equipment in the hospital room, such as faucets and soap dispensers will be replaced by
      sensor-based (e.g. touchless) controls.
    

Detailed description: 
      Bacteria and other microbes are everywhere, the majority of which are harmless. They live on
      our bodies, on everyday objects, in food, and in our environment. They are passed around
      through the many interactions with other people and our surroundings. Some are even
      beneficial, helping us digest our food or protecting us from infections caused by harmful
      microbes.

      In rare instances, some of the harmful microbes can cause infections. When a microbe causes
      an infection while we are in healthcare facilities, they are called "Healthcare-associated
      infections", or "HAIs". Examples that you may have heard of include Clostridium difficile,
      and MRSA (methicillin-resistant Staphylococcus aureus). Vancouver General Hospital already
      has some of the lowest HAI rates in the country. We have dedicated hospital workers that do a
      great job at preventing HAIs, but we are always looking for ways to be even better.
    

Intervention name(s): Engineered Room
Intervention type(s): Other
Intervention description(s): Touchless devices:
Hand sanitizers, faucets, paper towel dispensers, call devices, Ultraviolet C Aseptix™ Disinfection devices above bathroom doors
Copper products:
Room and bathroom entrance door hardware, over bed table and bed side table surfaces, chair metal arms, wardrobe handles and knobs, weigh scale, sinks, grab bars, light switch panels, toilet flush handles, faucets and handles, patient bed rails.
Titanium dioxide paint:
Room walls, head walls, light switches, bathroom wall shelves, toilet tank and bowl, head wall unit fixed equipment, television remote and Bed Control remote
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
PILOT STUDY OF THE EFFICACY AND SAFETY OF WF10 IN SUBJECTS SUFFERING FROM PERSISTENT ALLERGIC RHINITIS
Condition: Allergic Rhinitis
MeSH terms: Rhinitis; Rhinitis, Allergic
Study type: Interventional
Phase: Phase 2

Summary: 
      Objectives To assess the efficacy and safety of WF10 infusions in the treatment of subjects
      with persistent allergic rhinitis.

      Study Design Randomized, double-blind, placebo-controlled, parallel-group, single-centre
      trial.

      Subjects 50 subjects (25 per treatment group) with history of persistent allergic rhinitis
      for at least 2 years prior to enrolment and a positive allergen skin test. Subjects will be
      required to have a minimum mean score ≥6 for the baseline Total Nasal Symptom Score (TNSS)
      (mean score of morning and evening reflective TNSS assessments for the 3 days prior to
      randomization and treatment.

      Treatments At the first treatment visit (T1), subjects that comply with the inclusion and
      exclusion criteria will be randomized into one of two treatment groups: WF10, or placebo.

      Each individual treatment dose of study drug solution is 0.5 mL/kg body weight, diluted into
      500 mL saline solution. Treatment will be administered once daily for 5 consecutive days
      (Visits T1-T5) via intravenous infusion.
    


Intervention name(s): WF10; NaCl Solution
Intervention type(s): Drug; Drug
Intervention description(s): 0.5 mg/kg B.W.; NaCl Solution
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Use of EL-FIT App to Promote Physical Activity
Condition: End Stage Liver DIsease; Cirrhosis, Liver
MeSH terms: Liver Diseases; End Stage Liver Disease; Liver Cirrhosis
Study type: Interventional

Summary: 
      Transplant-eligible patients with cirrhosis and ESLD, age 40-70, MELD >/= 10 referred to
      transplant physical therapy will be invited to participate. The investigators will exclude
      those who lack a smartphone or the understanding of its functionality, lack home wireless
      internet, or have recurrent/persistent overt hepatic encephalopathy. Following signing of
      informed consent, each participant will be given a Fitbit Charge 3 and have EL-FIT and Fitbit
      apps downloaded to their smartphone. After a brief session with a member of the research team
      explaining the basic components and functionality of EL-FIT and Fitbit, patients will be
      provided with general physical activity recommendations (as per our current standard of care)
      and asked to explore all features of EL-FIT and Fitbit apps, up until their 12-week follow-up
      visit. Phone calls to incentivize physical activity and exercise will be performed by members
      of the research team.
    

Detailed description: 
      The study consists of two visits, baseline and 12-week follow-up, with at least one follow-up
      phone call on a weekly basis. Visit one is expected to last for 30 minutes and visit 2 for 60
      minutes, whereas each phone call should take no more than 15 minutes. Twice during the study
      period, the investigators will draw serum and plasma samples for future translational
      research. Daily, the physical trainer will review collected data on EL-FIT research database
      and Fitabase. Each participant will have an exit interview by the end of week 12 with the
      trainer and a member of the research team to talk about their impressions of using EL-FIT and
      Fitbit, through a structured questionnaire assessing about how user friendly it was to use
      the EL-FIT app. Finally, trainers will be asked to compare the type of prescription that they
      provided to patients as part of the standard of care (based on liver frailty index or
      6-minute walk test), to compare it with the allocation provided by EL-FIT stratification
      algorithm.

      To learn about how to improve EL-FIT the investigators will ask patients and their caregivers
      open-ended questions as part of their exit interview. This will allow us to identify barriers
      precluding them from keeping up with physical trainer recommendations, and what would they
      like to include to enhance motivation as part of a physical activity program. A member of the
      research team will act as a facilitator during this session.
    

Intervention name(s): Fitness intervention
Intervention type(s): Behavioral
Intervention description(s): Patients will follow exercise plans designed to promote physical activity (exercise and behavioral coaching).
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Study to Evaluate the Efficacy, Safety, and Tolerability of BOS-589 in the Treatment of Patients With Diarrhea-predominant Irritable Bowel Syndrome (IBS-D)
Condition: Diarrhea-predominant Irritable Bowel Syndrome
MeSH terms: Irritable Bowel Syndrome; Syndrome; Diarrhea
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is being conducted to evaluate in participants with diarrhea-predominant Irritable
      Bowel Syndrome (IBS-D) the abdominal pain response to BOS-589 after 4 weeks of treatment and
      to evaluate the overall safety and tolerability of BOS-589 in the treatment of IBS-D during 4
      weeks of treatment, relative to placebo (PBO).
    


Intervention name(s): BOS-589; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): oral tablets; oral tablets
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Irritable Bowel Syndrome; diarrhea; BOS-589