Effect of Iron and Vitamin D Supplementation to Iron Status in Iron Deficiency Anemia
Condition: Iron Deficiency, Anaemia in Children
MeSH terms: Anemia; Anemia, Iron-Deficiency; Iron Deficiencies
Study type: Interventional

Summary: 
      Iron and vitamin D are two essential micronutrients for the normal growth of young children,
      and their deficiencies are still a major health problem in developing countries, including
      Indonesia. A significant association between vitamin D deficiency and anemia has been
      reported throughout the world. Several studies in various populations all over the world
      suggest a high degree of association between Iron deficiency anemia and vitamin D deficiency.
      It is still controversial which deficiency causes the other but this association should be
      addressed in view of a better treatment proposal. The aim of the present study was to
      determine the effect of vitamin D supplementation on iron status in iron deficiency anemia.
    

Detailed description: 
      This research is a randomized controlled trial study conducted in Makassar, South of
      Sulawesi, Indonesia from April to October 2023. This study was conducted on children with a
      diagnosis of iron deficiency anemia. Patients were divided into two groups, namely group A
      which received standard therapy (Fe preparations) 3 mg/kgBW/day, and group B (which received
      standard therapy combination vitamin D, 400IU).

      The inclusion criteria in this study were children aged 1-5 years, diagnosed with iron
      deficiency anemia, and parents/caregivers willing to include their children in this study.
      Children who had received iron preparation, and previous blood transfusion were excluded in
      this study. Patients who refused blood tests after giving therapy for 4 weeks were declared
      dropouts.

      Researchers will provide informed consent to parents/caregivers of children who met the
      research criteria. Anamnesis, general physical examination, and complete blood count (CBC)
      analysis were carried out: hemoglobin (Hb), Red Blood cell (RBC), Mean erythrocyte volume
      (MCV), Mean erythrocyte hemoglobin (MCH), Reticulocytes, serum iron, and serum ferritin. Iron
      deficiency anemia if the level of hemoglobin <11 g/dL, microcytic Hypochromia, serum ferritin
      < 30 pg/dl, then given iron and vitamin D preparation for 4 weeks, then checked again
      complete blood count, serum fe and serum ferritin. The research results are recorded in a
      research form and the data is grouped and SPSS version 21.0 software is used for data
      analysis. A P value <0.05 was considered for statistical analysis. This study was approved by
      the ethics and research committee of the faculty of medicine, at Hasanuddin University
    

Intervention name(s): Elemental iron; Elemental iron and Vit D
Intervention type(s): Drug; Drug
Intervention description(s): Group A who received standard therapy (Fe preparations) 3 mg/kg BW/day; Group B received standard therapy (Fe preparations) 3 mg/kgBW/day combination with vitamin D, 400IU).
Other intervention name(s): Iron supplementation; Iron supplementation with Vitamin D
Intervention MeSH terms: Vitamin D; Iron
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: children with a diagnosis of iron deficiency anemia age 1-5 years. Patients were divided into two groups, namely group A which received standard therapy (Fe preparations) 3 mg/kgBW/day, and group B (which received standard therapy combination vitamin D, 400IU).
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: vitamin D; Iron status; Iron deficiency anemia