Exercise Training and Kidney Transplantation
Condition: Solid Organ Transplant Rejection; Chronic Kidney Failure; Quality of Life; Inflammation; Muscle Weakness
MeSH terms: Muscle Weakness; Renal Insufficiency; Kidney Failure, Chronic; Inflammation
Study type: Interventional

Summary: 
      The goal of this clinical trial is to investigate the physiological and molecular effects of
      exercise training in transplant recipients. The main questions it aims to answer are:

        1. Can exercise training improve physical fitness and muscle strength in transplant
           recipients?

        2. Can exercise training modulate inflammatory profile, hormones, lipid profile, and
           exercise-induced molecules in transplant recipients?

        3. Can exercise training improve blood pressure and endothelial health in transplant
           patients?

      Participants will be invited to an exercise training program 6-month after their transplant
      surgery. Body composition, physical assessment, and blood draw will be assessed at baseline
      and 12-weeks after exercise or control regimen.

      Researchers will compare exercise group vs. routine care group to see if exercise training
      impact the health-related outcomes of this population.
    

Detailed description: 
      The study will involve inviting participants to join an exercise training program six months
      after their transplant surgery. The research will include baseline assessments and
      measurements, such as body composition, physical assessment, and blood draws. These
      assessments will be conducted both at the beginning of the study and 12 weeks after
      participants have undergone either the exercise regimen or a control regimen.

      The research team will compare two groups: the exercise group and the routine care group. The
      goal is to examine whether participating in an exercise training program has a significant
      impact on various health-related outcomes in transplant recipients when compared to
      individuals receiving standard care.

      This clinical trial seeks to understand the potential benefits of exercise training on
      physical fitness, quality of life, inflammatory and molecular profiles, as well as
      cardiovascular health in individuals who have undergone organ transplantation. The comparison
      between the exercise group and the routine care group will provide valuable insights into the
      effectiveness of exercise interventions for this specific population.
    

Intervention name(s): Exercise training; Continue exercising; Discontinue exercising
Intervention type(s): Other; Other; Other
Intervention description(s): Participants will engage in combined training five times a week, with activities including 2 minutes of stationary marching and a set of 15 repetitions for squats, bilateral hip abduction, plantar flexion, floor abdominal exercises, and arm flexion with the knee close to the ground. Additionally, twice a week on non-consecutive days, volunteers partake in 20 minutes of aerobic walking.
The second program starts with a 2-minute stationary march, followed by 2 sets of 12 repetitions for free squats, hip abduction, plantar flexion, stiff-legged deadlifts, arm flexion with knee support, floor abdominal exercises, and concludes with 30 minutes of aerobic exercise.
The third program starts with a 2-minute stationary march, followed by 3 sets of 12 repetitions for free squats, hip abduction, plantar flexion, stiff-legged deadlifts, arm flexion, floor abdominal exercises, and includes thrice-weekly aerobic sessions lasting 30 minutes each.; Following the 12-week training regimen, patients will have the option to decide whether they wish to continue their exercise training. This group will include individuals who choose to persist with their exercise routine.; Following the 12-week training regimen, patients will have the option to decide whether they wish to continue their exercise training. This group will comprise individuals who opted not to continue their exercise routine.
Other intervention name(s): Exercise therapy; Exercise; Combined exercise
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Exercise training; Nephrology; Transplantation; Chronic kidney disease; Exercise physiology; Quality of life