bioihbjkbjnl/mcl2 huggingface dataset:
Airway Evaluation by McGrath Videolaryngoscope
Condition: Anesthesia
Study type: Interventional

Summary: 
      Difficult tracheal intubation is a cause of severe patient damage and death. There is not a
      good method to predict it. The McGrath Series 5 video laryngoscope can improve visualization
      of the glottic structures one to two grades. Moreover unlike a classical laryngoscope with a
      Macintosh blade, the McGrath provides a view of the glottis without requiring alignment of
      the oral, pharyngeal and laryngeal axes. In this study, the investigators will use it to
      compare the Cormack-Lehane score in sedation and anesthesia condition. It helps to know the
      role of videolaryngoscope in predicting difficult intubation.
    

Detailed description: 
      -  The enrolled patients were given a bolus of sufentanil 0.3-0.5μg/kg to achieve Ramsay
           sedation score 2-3. The Cormack-Lehane score in sedation was evaluated by McGrath
           videolaryngoscope.

        -  Then the patients were induced with propofol. A bolus of rocuronium was given to
           facilitate intubation. The Cormack-Lehane score in anesthesia was recorded when
           intubated by McGrath videolaryngoscope.

        -  BMI, mouth opening, thyromental distance, intubation duration and ramsay sedation score
           were also recorded.

        -  To compare the Cormack-Lehane score in sedate and anesthesia condition
    

Intervention name(s): McGrath Videolaryngoscope
Intervention type(s): Device
Intervention description(s): A kind of portable videolaryngoscopes, produced by Aircraft Medical. It has been used for difficult airway.
Intervention model: Single Group Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Diagnostic
Keywords: videolaryngoscope; tracheal intubation; Cormack-Lehane grade; airway evaluation; sedation; anesthesia
Performance of Red Tinted Contact Lenses on Colour Defects
Condition: Color Vision Defects; Color Blindness
MeSH terms: Blindness; Color Vision Defects
Study type: Interventional

Summary: 
      This study aimed to relate and compare the performance of 4 types of red-tinted contact
      lenses (CL) with the Total Error Score (TES) from the Farnsworth-Munsell 100 Hue test on
      colour deficient subjects. Only 6 subject with colour vision defect was tested in this study.
    

Detailed description: 
      Six congenital CVD subjects were recruited. After colour vision screening using Ishihara
      plate, the Farnsworth-Munsell 100 Hue test was carried out to determine the type and severity
      of colour vision deficiency. Four types of red-tinted CL (Type A, B, C and D) were used. The
      performance of each of these lenses was determined through the comparison of error scores in
      the Ishihara test before and after wearing tinted contact lens on only the non-dominant eye.
      Then, the transmittance of each tinted CL was determined using a spectrophotometer. All these
      lenses were fitted on the subjects in one day where the subjects were given a 30-minute break
      for each intervention.
    

Intervention name(s): red tint contact lenses
Intervention type(s): Device
Intervention description(s): to compare the performance of these lenses.
Other intervention name(s): IGEL Red tint lens type1; IGEL Red tint lens type 2; OCULUS Red tint lens; MAXVUE Red tint lens
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 6 colour defect subjects eye were inserted with 4 different types of red tinted contact lenses at different times and then tested with Ishihara Test and 100 Hue Test to obtain the score values. This was done only on one non dominant eye of subject.
Masking: Single (Outcomes Assessor)
Primary purpose: Device Feasibility
Keywords: Anomalous Trichromats; Color Vision Defect; Contact Lenses
To Determine The Efficacy and Safety of GDC-0449 in Patients With Basal Cell Nevus Syndrome (BCNS)
Condition: Basal Cell Nevus Syndrome; Gorlin Syndrome
MeSH terms: Nevus; Basal Cell Nevus Syndrome; Nevus, Pigmented; Syndrome
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to reduce the number of new surgically eligible BCCs by 50%
      appearing during month 3-18 of medication ingestion.
    

Detailed description: 
      This is a Phase II, 18 month, double blind, randomized placebo-controlled, two arm
      multicenter clinical study design. During the 18-month treatment period, the safety and
      chemopreventive efficacy of 150 mg/day GDC-0449 versus placebo will be assessed, and include
      evaluations of the skin at monthly intervals for the first three months and then every 3
      months for the next 15 months. Removal of new surgically eligible BCCs (SEBs) will be done by
      primary skin care physicians (PSCPs) or at Study Centers. A Data Safety Monitoring Board
      (DSMB) will review unblinded results for an interim analysis when 20 subjects have completed
      12 months of drug. This review will focus on adverse events and efficacy results. Subjects
      will be monitored for the development of new SEBs after they discontinue study treatment. At
      the end of the 18 months, given that the observed adverse events are minimal, patients on
      placebo will be offered the opportunity to take GDC-0449 for 18 months in an open label
      continuation, followed by six months observation, and patients on GDC449 will be monitored
      for the next 24 months for assessment of the duration of benefit after stopping the drug.
    

Intervention name(s): GDC-0449
Intervention type(s): Drug
Intervention description(s): capsule, 150 mg, one pill daily, 18 months
Other intervention name(s): Hedgehog Inhibitor; Hedgehog Antagonist
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Tolerance of a Probiotic Formula
Condition: Safety Issues
Study type: Interventional

Summary: 
      Evaluate the tolerance of a probiotic formula in infants
    


Intervention name(s): Probiotics; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Other
An Evaluation of Glycemic Control Effects of Mono Therapy CKD-501 in Patients With Type 2 Diabetes Mellitus
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to evaluate and confirm hypoglycemic efficacy and safety of
      CKD-501 as mono therapy in patients with type 2 diabetes treated once daily for 24 weeks in
      comparison to placebo.
    

Detailed description: 
      Diabetes Mellitus is classified into type 1 diabetes and type 2 diabetes mellitus according
      to the causes of diabetes onset and the treatment of symptoms.

      In type 2 diabetes, the combination of insulin resistance and insulin deficiency is working.
      Diabetes mellitus causing many complications and hospitalization is one of chronic metabolic
      disorder and diabetes mortality rate has been gradually increasing percentage.

      CKD-501 is highly selective peroxisome proliferator-activated receptor-gamma agonist that
      decreases insulin resistance in the periphery and liver resulting in increased
      insulin-dependent glucose disposal and decreased hepatic glucose output. In vivo, It
      demonstrates that CKD-501 improves even more glycemic and lipid control in comparison to
      rosiglitazone and pioglitazone.

      The aim of this phase 3 study was to evaluate the efficacy and safety of CKD-501 once daily
      for 24 weeks as a monotherapy in type 2 diabetes mellitus. Furthermore, the extension study
      for additional 28 weeks is designed to confirm long term safety of CKD-501 as an oral
      hypoglycemic agent.
    

Intervention name(s): CKD-501 0.5mg; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 0.5 mg/tablet, orally, 1 tablet once daily for 24 weeks or 52 weeks (If extension study); Indistinguishable tablet from CKD-501, Orally, 1 tablet once daily for 24 weeks
Other intervention name(s): Lobeglitazone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Diabetes Mellitus, Type 2; glitazone; Type II Diabetes; Hypolipidemic; oral hypoglycemic agent
Evaluation of the Effects of Omeprazole and Rifampin on the Pharmacokinetics of VX-548 in Healthy Participants
Condition: Pain
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the pharmacokinetics and safety of VX-548 and its
      metabolite in the absence and presence of omeprazole or rifampin, in healthy participants.
    

Detailed description: 
      This clinical trial information was submitted voluntarily under the applicable law and,
      therefore, certain submission deadlines may not apply. (That is, clinical trial information
      for this applicable clinical trial was submitted under section 402(j)(4) (A) of the Public
      Health Service Act and 42 CFR 11.60 and is not subject to the deadlines established by
      sections 402(j)(2) and (3) of the Public Health Service Act or 42 CFR 11.24 and 11.44.).
    

Intervention name(s): VX-548; Omeprazole; Rifampin
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Tablets for oral administration.; Tablets for oral administration.; Capsules for oral administration.
Intervention MeSH terms: Rifampin; Omeprazole
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Efficacy and Safety Study of SHR-1819 Injection in Adult Patients With Severe Atopic Dermatitis
Condition: Moderate to Severe Atopic Dermatitis
MeSH terms: Dermatitis, Atopic; Dermatitis; Eczema
Study type: Interventional
Phase: Phase 2

Summary: 
      This trial was designed to evaluate the efficacy and safety of SHR-1819 injection in patients
      with atopic dermatitis
    


Intervention name(s): SHR1819; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Treatment group A：SHR-1819 injection dose 1， Treatment group B：SHR-1819 injection dose 2， Treatment group C：SHR-1819 injection dose 3，; Treatment group D：placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Acupuncture for Tonsillectomy Pain
Condition: Children; Postoperative Pain; Tonsillar Hypertrophy; Obstructive Sleep Apnea; Chronic Tonsillitis
MeSH terms: Tonsillitis; Sleep Apnea, Obstructive; Pain, Postoperative; Hypertrophy
Study type: Interventional

Summary: 
      Pain after tonsillectomy can be severe and last ten days.

      Various new surgical instruments have been developed over the years in an attempt to reduce
      postoperative pain with mixed results and increased costs; no single tonsillectomy technique
      is superior to the rest. Patients are discharged to home usually on the day of surgery and
      often suffer significant pain and nausea. Pain medication is often prescribed which can cause
      nausea, vomiting and constipation. Children in pain are reluctant to take in fluids and may
      require intravenous hydration at an emergency department.

      "Battlefield acupuncture " has been recently developed by the US Air Force and is now being
      used in Iraq and Afghanistan on wounded warriors suffering severe acute pain from trauma.
      This protocol consists of five acupuncture points on the outer ear.

      A recent study has demonstrated decreased pain and agitation in children undergoing ear tube
      insertion. Ear tube patients have mild discomfort compared to tonsillectomy patients and are
      able to attend school the next day.

      The investigators have been encouraged by the benefits of acupuncture during surgery for ear
      tube patients and also wounded warriors recovering from their injuries. These findings
      motivated us to see if acupuncture during tonsillectomy surgery would result in less pain and
      nausea.
    


Intervention name(s): Acupuncture; Sham Control
Intervention type(s): Other; Other
Intervention description(s): Battlefield acupuncture protocol; Sham control acupuncture
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: tonsillectomy; adenotonsillectomy; acupuncture; children; postoperative pain; postoperative nausea
Treatment Resistance Related With Gene Expression Profile of Diffuse Large B-cell Lymphoma
Condition: Diffuse Large B-cell Lymphoma
MeSH terms: Lymphoma; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse
Study type: Observational

Summary: 
      The investigators perform a retrospective microarray gene expression profiling study of FFPE
      from a cohort of DLBCL patients with whole genome cDNA mediated Annealing Selection and
      Ligation (WG-DASL) assay. The investigators also study the pattern of microRNA from patients
      with diffuse large B-cell lymphoma. The results of gene expression profiles and microRNA is
      correlated with clinical outcomes of diffuse large B-cell lymphoma.
    

Detailed description: 
      1. Whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay

             -  Diffuse large B-cell lymphoma patients

             -  Paraffin-embedded tissue

             -  End points: Progression-free survival, overall survival

             -  Statistics: Leave one-out method

        2. Nano string assay for microRNA

             -  Diffuse large B-cell lymphoma patients

             -  Paraffin-embedded tissue

             -  End points: Progression-free survival, overall survival

             -  Statistics: Leave one-out method
    

Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Patients with diffuse large B-cell lymphoma
      
Biospecimen description: 
      Parrafin-embedded tissue blocks
    
Keywords: Lymphoma; Prognosis; Relapse; Gene; microRNA
Video-Based Games for Upper Limb Rehabilitation in Cerebral Palsy
Condition: Cerebral Palsy; Rehabilitation
MeSH terms: Cerebral Palsy
Study type: Interventional

Summary: 
      The aim of the present study is to compare the effects of Neurodevelopmental Treatment
      (NDT)-based upper limb rehabilitation and video-game based therapy (VGBT) with Nintendo® Wii
      and LMC games on upper extremity functions in patients with Cerebral Palsy (CP).
    

Detailed description: 
      The investigators hypothesized that VGBT using the Nintendo® Wii and LMC would be a usable
      tool to train manual dexterity in patients with CP as comprehensive and holistic therapy.

      The NDT program for both groups will be routinely applied according to each child's
      individual needs and included tonus regulation, support of sensation, perception and motor
      development for gross motor function.

      The two different patient-centered rehabilitation programs will be conducted with an average
      of one hour sessions three times a week for 8 weeks in both groups. The two different
      patient-centered programs will be as VGBT with Nintendo® Wii and LMC games (Group I) and
      NDT-based upper limb rehabilitation (Group II).
    

Intervention name(s): VGBT with Nintendo® Wii and LMC games; NDT-based upper limb rehabilitation
Intervention type(s): Device; Behavioral
Intervention description(s): Nintendo Wii and LMC games will be used for upper limb rehabilitation in Cerebral Palsy. The games are tennis and boxing for Nintendo Wii, Leapball and CatchApet for LMC.; NDT-based upper limb rehabilitation includes using real materials (clothes, spoons, pencils, buttons, rope, etc.) such as getting dressed and eating etc. Also, It will practised with the materials such as velcro cylinders, skill cubes, exercise bands, screw sets, therapeutic putty, and tripled coordination tools.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of AMG 890 in Subjects With Elevated Plasma Lipoprotein(a)
Condition: Cardiovascular Disease
MeSH terms: Cardiovascular Diseases
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a first-in-human, randomized, double-blind, placebo-controlled, single ascending dose
      study in subjects with elevated plasma Lipoprotein(a) [Lp(a)]. AMG 890 will be evaluated in
      approximately 80 subjects to assess safety, tolerability, pharmacokinetics and
      pharmacodynamic effects.
    


Intervention name(s): AMG 890; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Ascending Single Doses of AMG 890; Calculated volume to match experimental drug.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Other
Growth and Development of Children With Congenital Heart Disease (CHD)
Condition: Researcher-Subject Relations
MeSH terms: Heart Diseases; Heart Defects, Congenital
Study type: Interventional

Summary: 
      The Effect of Individualized Nutrition Training Given to the Families of Children with
      Congenital Heart Disease (CHD) in the Post-Operative Period on their Growth and Development
      This study was conducted experimentally to determine the effects of individualized nutrition
      training given to mothers of children who had surgery for CHD on their growth and
      development.
    

Detailed description: 
      The Effect of Individualized Nutrition Training Given to the Families of Children with
      Congenital Heart Disease (CHD) in the Post-Operative Period on their Growth and Development
      This study was conducted experimentally to determine the effects of individualized nutrition
      training given to mothers of children who had surgery for CHD on their growth and
      development.

      The data of the study were collected at Çukurova University Medical Faculty Balcalı Hospital
      Cardiovascular Surgery between 20/01/2021-30/06/2021. The research was conducted by
      interviewing the families of 42 children with congenital heart disease. Personal information
      form, growth parameters and Ankara Developmental Screening Inventory were applied to three
      groups formed as two experimental and control groups by randomization method. Family-centered
      care and individualized nutrition training were applied to the first experimental group who
      was fed orally and and the second experimental group orally and nutritionally fed. These
      trainings were about nutritional contents suitable for the age of the baby, the way of
      preparing the food and meeting the calorie needs of the baby. No training was given to the
      control group during the research process. The growth and development parameters of all three
      groups were evaluated and the effect of education was examined.
    

Intervention name(s): family-centered nutrition education
Intervention type(s): Other
Intervention description(s): There is a training program prepared by the researcher to increase the nutritional knowledge of mothers with children aged 0-3. The definition and importance of nutrition in the session, respectively, adequate and balanced nutrition, insufficient and unbalanced nutrition damages, grouping of nutrients, feeding 0--6 months old baby, feeding premature baby, breastfeeding, situations to be considered while breastfeeding, starting additional foods, 9-12 monthly baby nutrition, 1-3 years old child nutrition and nutritional nutrition support.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: The research is a randomized controlled experimental study.
Masking: Double (Care Provider, Investigator)
Primary purpose: Supportive Care
Keywords: Child Health and Nursing; Congenital Heart Disease; Family Centered Care; Growth and Development; İndividual Nutrition Education.
Triclosan Toothpaste and Third Molar Surgery
Condition: Dry Socket; Wound Infection
MeSH terms: Wound Infection; Dry Socket
Study type: Interventional

Summary: 
      Triclosan containing dentifrices are effective in the prevention of inflammatory
      complications following third molar surgery through reducing preoperative oral bacteria load.
    

Detailed description: 
      This study may provide evidence on the effect of triclosan containing dentifrice on oral
      bacteria and oral inflammation prior to third molar surgery, and on the incidence of
      inflammatory complications after the surgery. If proven effective, dentifrice containing
      triclosan may be recommended prior to tooth extractions and replace antibiotics and other
      antimicrobial products as a prophylactic procedure before oral surgery procedures.
    

Intervention name(s): Colgate Total Toothpaste; Colgate Regular Toothpaste
Intervention type(s): Other; Other
Intervention description(s): Toothbrushing with Colgate Total Toothpaste; Toothbrushing with Colgate regular toothpaste
Other intervention name(s): triclosan; dentifrice; fluoride; dentifrice
Intervention MeSH terms: Listerine; Triclosan; Fluorides; Sodium Fluoride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: third molars; triclosan; toothpaste; dry socket; wound infection