bioihbjkbjnl/mcl2 huggingface dataset:
Remote Ischemic Preconditioning of Dynamic Cerebral Autoregulation in Healthy Adults
Condition: Ischemic Preconditioning
MeSH terms: Ischemia
Study type: Interventional

Summary: 
      The purpose of this study is to determine the impact of remote ischemic preconditioning on
      dynamic cerebral autoregulation and related hematology indexes in healthy adults.
    

Detailed description: 
      Remote ischemic preconditioning(RIPC) is the phenomenon whereby brief cycles of ischemia and
      reperfusion, applied to a distant organ, provide protection to the target organ. Dynamic
      cerebral autoregulation(dCA), a mechanism to maintain the cerebral blood flow, has been
      proved to be critical for the occurrence,development and prognosis of ischemic neurovascular
      disease. In this study, we hypothesis that RIPC provides neuro-protection by means of
      improving dCA.
    

Intervention name(s): Remote ischemic conditioning equipment; Intravenous blood collection; dCA measurement
Intervention type(s): Device; Procedure; Procedure
Intervention description(s): The RIPC consisted of 4 cycles of extremities ischemia (5-minute blood-pressure cuff inflation to 200 mm Hg, followed by 5-minute cuff deflation). The tourniquets were applied to one side upper arm and other side thigh. This intervention was undertaken one time in total.; Nurses will collect intravenous blood 6ml twice(at baseline and 1h after RIPC).The blood samples will be stored for laboratory test.The blood samples only use for the trial.; Serial measurements of dCA were performed at 7 time points, baseline, 1h, 3h, 6h, 9h, 12h, 24h after RIPC.The continuous ABP was measured non-invasively using a servo-controlled plethysmograph (Finometer Pro, the Netherlands) at the middle finger. Two 2 MHz transcranial Doppler probe was used to measure continuous cerebral blood flow velocity (CBFV) simultaneously in the bilateral middle cerebral arteries at a depth of 45-60 mm Endtidal CO2 was monitored using a capnograph (MultiDop X2, DWL, Sipplingen, Germany). The probes were placed over temporal windows and fixed with a customized head frame. CBFV and continuous arterial blood pressure were recorded simultaneously from each subject in the supine position for 10 minutes. All data were recorded for further assessment and analysis.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Ischemic Preconditioning; dynamic cerebral autoregulation
Long-term Study Of Paroxetine in Women and Men
Condition: Social Phobia
MeSH terms: Phobic Disorders; Phobia, Social
Study type: Interventional
Phase: Phase 3

Summary: 
      This study is designed to evaluate the efficacy and safety in Social Anxiety Disorder (SAD)
    


Intervention name(s): BRL29060A; paroxetine hydrochloride hydrate
Intervention type(s): Drug; Drug
Other intervention name(s): BRL29060A
Intervention MeSH terms: Paroxetine
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Social; (SAD); Anxiety; Disorder
Implementation of Standing Desks at School
Condition: Health Behavior
Study type: Interventional

Summary: 
      Since sedentary time is related to various health outcomes and is already highly prevalent in
      childhood and adolescence, effective strategies are needed to tackle this health problem.
      Children and adolescents spend the majority of the day in a classroom while sitting at a
      desk. Therefore, the classroom is an important setting for implementing specific strategies
      to reduce sedentary time.

      One of the strategies that gained more attention during the past years is replacing
      traditional desks and chairs with standing desks.

      This project evaluates the implementation of standing desks in primary and secondary schools
      via a clustered randomized controlled trial using an intervention and control condition.
      Effects on sedentary time during in class, sedentary activities during leisure time, breaks
      in sedentary time, and related determinants (secondary outcomes) are evaluated.

      Next to effect evaluation, it is also equally important to evaluate how teachers and pupils
      perceive this change in the classroom environment. Both groups need to be positive in order
      to obtain the adoption and sustainability. Therefore, focus groups with pupils and interviews
      with teachers are conducted, with a specific focus on the perceived barriers. Moreover, the
      process evaluation is conducted quantitatively as well by using questionnaires in pupils and
      teachers.

      The project results will lead to recommendations on how to broadly implement standing desks
      into primary and secondary schools.
    


Intervention name(s): Implementation of standing desks
Intervention type(s): Behavioral
Intervention description(s): Three standing desks will be introduced to the classroom
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: One intervention and one control condition
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Sedentary behavior
Effects of Pin and Vacuum Assisted Suspension Systems
Condition: Amputees; Prosthesis User; Artificial Limbs
Study type: Interventional

Summary: 
      This study was performed to determine the presence of any difference between Pin Suspension
      (PS) and Active Vacuum Suspension (AVS) on walking capacity, functional mobility, weight
      bearing in the prosthetic side, prosthetic satisfaction and body image were evaluated. Nine
      patients who don't have an obstacle to both socket applications in terms of stump height,
      type and edema were evaluated in this study. Both suspension systems were administered to the
      patients included in the study. First, amputees have used PS for 3 months following alignment
      of the prosthesis and training period. Then again they used AVS for 3 months following
      alignment of the prosthesis and training period. For each system, after adapting prosthesis
      'LASAR posture' was used to evaluate weight bearing on the prosthetic side, '6 Minute Walk
      Test' for walking capacity, 'Time Up and Go' test for functional mobility, 'Prosthetic
      Satisfaction Index' for prosthetic satisfaction and 'Amputee Body Image Scale' for body.
      There were statistically significant difference between PS and AVS in terms of prosthetic
      side weight bearing percentage, walking capacity, functional mobility and prosthetic
      satisfaction (p<0.05), in favor of AVS. There were not statistically significant difference
      between the body image scores (p>0.05). From the view of function and prosthetic
      satisfaction, AVS was found to be more effective in transtibial amputees. It is believed that
      our study will be a guide to the future studies including higher number of amputees,
      different amputation levels and different suspension systems.
    


Intervention name(s): Pin Suspension System (a prosthetic suspension system); Vacuum-Assisted Suspension System (a prosthetic suspension system)
Intervention type(s): Other; Other
Intervention description(s): Participants used the PSS for three months following fabrication and adjustment of the prosthesis, and a prosthetic training period.; After PSS, participants employed the VASS for three months after a similar training period.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Amputees; Artificial Limbs; Prosthetic designs; Rehabilitation of prostheses users; Prosthetic suspension systems
High Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure
Condition: Respiratory Insufficiency
MeSH terms: Respiratory Insufficiency
Study type: Interventional

Summary: 
      The purpose of this study is to compare two common methods of providing respiratory support:
      nasal continuous airway pressure and high flow nasal cannula to see what effect it has on
      babies breathing. The investigators also will compare the effects of slightly changing the
      level of support these two different types of therapy on how easily your baby is breathing.
      Changes in the level of support and between these two respiratory support modalities are
      frequently done and are part of the routine care in the neonatal intensive care unit.
    


Intervention name(s): Pulmonary Function Testing & esophageal pressure monitoring; Pulmonary function testing and esophageal pressure
Intervention type(s): Other; Other
Intervention description(s): Infants who are currently on NCPAP will have pulmonary function testing (PFTs)and esophageal pressure performed while on 2 different settings of NCPAP. These infants will then be transitioned HFNC and will undergo PFTs and esophageal pressure while on different HFNC settings. The infant will then be returned to NCPAP at the same settings they were on prior to any study interventions.; Infants who are currently on HFNC will have pulmonary function testing (PFTs) and esophageal pressure performed while on 2 different settings of HFNC. These infants will then be transitioned NCPAP and will undergo PFTs and esophageal pressure while on 2 different NCPAP settings. The infant will then be returned to HFNC at the same settings they were on prior to any study interventions.
Other intervention name(s): Pulmonary Function Testing; Esophageal pressure; Pulmonary Function Testing; Esophageal pressure
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Respiratory insufficiency; Infants; High Flow Nasal Cannula (HFNC); Nasal Continuous Positive Airway Pressure (NCPAP)
Ultrasound Guided Ureteroscopy and Ureteric Stones
Condition: Ureteric Stone
MeSH terms: Ureteral Calculi; Ureterolithiasis
Study type: Interventional

Summary: 
      The prevalence of urolithiasis is steadily increasing with an estimation of 1 out of 11
      people in the United States. The prevalence of calculi in Afro-Asian region including Arab
      Republic of Egypt ranges from 4% to 20%. Ureteroscopy is one of the first line treatments for
      definitive management of ureteric stones. Conventional ureteroscopy relies on intraoperative
      fluoroscopy for visualization and guidance, exposing the patient, surgeon and operating room
      staff to ionizing radiation. To minimize the hazards of ionizing radiation there has been a
      trend toward radiation free alternative imaging modalities . Ultrasound provides an excellent
      alternative for upper urinary tract imaging because it is radiation free, rapid, portable and
      allows excellent visualization of the renal pelvis and calyces. There is increasing awareness
      and concern about the clinical use of ionizing radiation and the need to decrease exposure of
      patients and medical professionals. Ultrasound guided ureteroscopy in pregnant females and
      children- in whom fluoroscopy is to be minimized or avoided when possible - has been
      reported.
    


Intervention name(s): ureteroscopy; Ultrasonography
Intervention type(s): Procedure; Radiation
Intervention description(s): The patients will be subjected to rigid ureteroscopy; The patients will be subjected to Ultrasonography
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Effects of Vitamin D Supplementation in Obesity
Condition: Vitamin D Deficiency; Obesity
MeSH terms: Obesity; Vitamin D Deficiency
Study type: Interventional
Phase: Phase 4

Summary: 
      Obesity is an increasing health problem with numerous metabolic complications. Vitamin D
      deficiency is common in obesity, and in epidemiological studies vitamin D deficiency has been
      linked to metabolic complications, such as type 2 diabetes, insulin resistance and
      cardiovascular disease, as well as myopathy, osteoporosis and depression. In obesity, a low
      grade inflammation is present in the fat tissue, thereby releasing inflammatory molecules to
      the blood stream. In cell line studies as well as small clinical studies vitamin D has been
      shown to have the ability to reduce inflammation and cell growth.

      In the present study the investigators wish to investigate the effect of vitamin D on fat-,
      muscle and bone metabolism. 30 healthy obese subjects will be treated with cholecalciferol
      175 micrograms daily for 6 months and will be compared with 30 healthy obese subjects treated
      with placebo.

      The investigators hypothesize that restoring vitamin D levels in vitamin D deficient obese
      subject will reduce inflammation and thereby reduce obesity-related complications.

      The effect will be evaluated as follows:

        -  Levels of circulating inflammatory markers will be examined in blood samples collected
           prior to and after treatment.

        -  Effects on fat- and muscle metabolism will be evaluated in fat- and muscle samples taken
           before and after treatment.

        -  Effects on fat distribution will be evaluated by MRI scan before and after treatment.

        -  Effects on insulin sensitivity will be evaluated by hyperinsulinaemic euglycaemic clamp
           performed on a subgroup of subjects with impaired fasting glucose.

        -  Effects on bone marrow density will be evaluated by DEXA scans before and after
           treatment.

        -  Effects on quality of life and depression score will be evaluated by questionnaires used
           before and after treatment.
    


Intervention name(s): Cholecalciferol; placebo
Intervention type(s): Drug; Drug
Intervention description(s): oral cholecalciferol tablets of 175 micrograms daily for 6 months; oral placebo tablets similar to active comparator
Other intervention name(s): vitamin D
Intervention MeSH terms: Vitamin D; Cholecalciferol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
CRANIO-CAUDAL AND LATERAL APPROACH FOR RECURRENT LARYNGEAL NERVE
Condition: Recurrent Laryngeal Nerve Injuries
MeSH terms: Laryngeal Nerve Injuries; Recurrent Laryngeal Nerve Injuries; Recurrence
Study type: Interventional

Summary: 
      The recurrent laryngeal nerve (RLN) dissection should be performed cranio-caudally in TOETVA
      approach.The aim of this study was to compare the cranio-caudal and lateral approach for RLN
      dissection in regard with the rates of LOS during conventional thyroidectomy using continuous
      intraoperative nerve monitoring (CIONM).
    

Detailed description: 
      During the thyroid surgery, the identification of the recurrent laryngeal nerve (RLN) and the
      dissection through its entry point is still the gold standard in prevention of the nerve
      injury and to decrease the RLN palsy rate. Intraoperative nerve monitoring (IONM) has also so
      many benefits to search, identify and dissect the nerve through its course during thyroid
      surgery and especially the most important benefit of the IONM is to have real time
      information about the function of the RLN. Most of the endocrine surgeons use the
      inferolateral approach for RLN identification under the guidance of the IONM in the recent
      years. However after the definition of the transoral endoscopic thyroidectomy vestibular
      approach (TOETVA) technique, the approach to the RLN have to be changed to craniocaudal
      approach in which a way that most of the surgeons are not familiar with. The different
      approaches of the recurrent laryngeal nerve depend on the indications and on the surgeon's
      habit. Several approaches exist such as the superior approach ,the lateral approach, and the
      inferior approach.
    

Intervention name(s): Lateral approach; Cranio-caudal approach
Intervention type(s): Procedure; Procedure
Intervention description(s): Following the ligation of upper pole vessels, the thyroid lobe was pulled anteromedially and the RLN was dissected within the carotid triangle at the level of inferior thyroid artery (ITA).; Following the ligation of upper pole vessels, the upper pole was retracted antero-medially to expose crico-pharyngeal muscle. The RLN was identified at the point of entry both visually and with hand held stimulation probe
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: cranio-caudal approach; lateral approach; intraoperative nerve monitoring
Dietary Nitrate and Exercise to Augment Exercise Training Benefits in Subjects With DM+PAD
Condition: Peripheral Arterial Disease; Type II Diabetes Mellitus
MeSH terms: Peripheral Arterial Disease; Peripheral Vascular Diseases; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 2

Summary: 
      The hypothesis of this proposal is that in subjects with Type II diabetes mellitus (T2D) and
      peripheral arterial disease (PAD) with intermittent claudication (IC), regular consumption of
      a high nitrate supplement which raises plasma nitrite, in conjunction with 12 weeks of
      supervised exercise training at the limb ischemic threshold (SET) will produce a greater
      clinical benefit (increases in claudication onset time [COT] and peak walking time [PWT]
      relative to a group with the same exercise training but supplemented with placebo .This study
      is essentially exploratory in nature and designed to provide us with information to
      adequately develop power and execute a larger study. We have previously seen benefits from
      nitrate supplementation on function in PAD.
    


Intervention name(s): Beetroot Juice (Beet-It Stamina Shot) and Exercise Training; Placebo Comparator Beverage (Beet-It Stamina Shot) & Exercise Training
Intervention type(s): Drug; Other
Intervention description(s): The beverage is high in inorganic nitrate and bottled and supplied by James White Drinks. This supplement will be used in conjunction with supervised exercise training.; The beverage is identical in look and taste to Beet-It Stamina Shot but with active ingredient removed. It is also bottled and supplied by James White Drinks. This placebo supplement will be used in conjunction with supervised exercise training.
Other intervention name(s): James White Drinks; James White Drinks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Cardiovascular Diseases; Vascular Diseases; Arterial Occlusive Diseases; Diabetes; Exercise; Functional Capacity
Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy
Condition: Cervical Degenerative Disc Disease; Degenerative Spondylolisthesis; Spinal Stenosis
MeSH terms: Spinal Stenosis; Intervertebral Disc Degeneration; Spondylolisthesis
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate the safety and preliminary efficacy of NeoFuse in
      subjects with a diagnosis of degenerative disc disease (DDD) at 2 or more adjacent cervical
      vertebral levels between C3-C4 to C7-T1. All subjects in this study will undergo 2 or 3 level
      anterior cervical discectomy and fusion with anterior cervical plate fixation.
    

Detailed description: 
      This is a prospective, multicenter, randomized, single-blinded, controlled study evaluating
      safety and preliminary efficacy of immunoselected, culture-expanded, nucleated, allogeneic
      MPCs (NeoFuse) combined with MasterGraft Matrix in a commercially available PEEK cervical
      spacer compared to a cervical Allograft Spacer control in subjects undergoing 2 or 3 level
      anterior cervical discectomy and fusion with anterior cervical plate fixation.

      After the screening and surgical visits, each subject will be evaluated clinically and
      radiographically within 3 days and 30 days after surgery, and at 3, 6, 12, and 24 months
      after surgery.

      Subjects will be evaluated at the same time points for safety.
    

Intervention name(s): NeoFuse; Allograft
Intervention type(s): Biological; Procedure
Intervention description(s): Single Dose NeoFuse Surgical Implantation; Single Dose Allograft Surgical Implantation
Other intervention name(s): Anterior Cervical Discectomy and Fusion with NeoFuse; Cervical Spinal Fusion; Stem Cells; Anterior Cervical Discectomy and Fusion with Allograft; Cervical Spinal Fusion; Control
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Cervical Degenerative Disc Disease; Degenerative Spondylolisthesis; Spinal Stenosis; Stem cells; Adult Stem Cells; Anterior cervical discectomy and Fusion (ACDF); Cervical Allograft Spacer; Anterior Cervical Plate Fixation
Efficacy and Safety of FTY720 in Patients Who Receive a Kidney Transplantation
Condition: Kidney Transplantation
Study type: Interventional
Phase: Phase 3

Summary: 
      In patients who receive an organ transplant, their body considers this organ as foreign and
      attempts to destroy it. This is called rejection. All patients who receive an organ
      transplant, will take a combination of anti-rejection medications. These medications prevent
      the new organ from being rejected from the body. FTY720 is a new compound that helps prevent
      organ rejection.
    


Intervention name(s): FTY720
Intervention type(s): Drug
Intervention MeSH terms: Fingolimod Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Kidney,Transplantation, rejection, immunosuppression
Apatinib in Recurrent or Refractory Intracranial Central Nervous System Malignant Tumors
Condition: Efficacy and Safety
Study type: Interventional
Phase: Phase 2

Summary: 
      The patient was given a daily dose of apatinib 500mg (or based on weight). Individualized
      chemotherapy regimens were given based on molecular expression and prior chemotherapy.
    

Detailed description: 
      The patient was given a daily dose of apatinib 500mg (or based on weight). Individualized
      chemotherapy regimens were given based on molecular expression and prior chemotherapy. Brain
      MRI+MRS was examined every 3 months; Blood routine, urine routine and liver and kidney
      function were examined once a week.
    

Intervention name(s): apatinib; temodar
Intervention type(s): Drug; Drug
Intervention description(s): The patient was given a daily dose of apatinib 500mg (or based on weight). For adult, the dose of apatinib was prescribed with 425 mg or 500 mg per day and four weeks for a cycle. The dosage was modified to 250 mg if patients experienced ≧grade 2 hematologic adverse events, hand and foot syndrome, proteinuria, fecal ocular blood, or grade 3/4 hypertension, or other grade 3/4 adverse events. Apatinib was administrated until disease progression, unacceptable toxicity or death.; dose-dense temozolomide (100 mg/m2 , 7 days on with 7 days off ) , 28d
Intervention MeSH terms: Apatinib; Temozolomide
Intervention model: Single Group Assignment
Intervention model description: single arm
Masking: None (Open Label)
Primary purpose: Treatment