bioihbjkbjnl/mcl2 huggingface dataset:
Ultrasound Guided Erector Spinae Plane Block Versus Retrolaminar Plane Block
Condition: Post Operative Pain; Analgesia
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      Retrolaminar block (RLB) and erector spinae plane block (ESPB) are alternative approaches to
      paravertebral block (PVB) and are advantageous in that they are easier and safer techniques
      compared with the traditional PVB. These blocks are considered to be compartment blocks or
      interfascial plane blocks. In these approaches, local anesthetics are assumed to penetrate
      the superior costotransverse ligament and reach the paravertebral space, although the needle
      tip is not advanced into the paravertebral space.

      the study aim to evaluate and compare the analgesic efficacy of retrolaminar plane block and
      erector spinae plane block.
    


Intervention name(s): retrolaminar block; ESPB
Intervention type(s): Procedure; Procedure
Intervention description(s): curved probe will be placed 1-1.5 cm lateral to the target spinous process after identification of the lamina, the needle will be advanced caudally until it contacts the lamina; curved probe will be placed 2-3 cm lateral to the spine using a sagittal approach at the level of T8. After identification of erector spinae muscle and transverse processes, the needle will be inserted deeply into the erector spinae muscle.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Prevention
Pain Assessment in the Intensive Care Unit
Condition: Delirium; Critical Illness
MeSH terms: Critical Illness
Study type: Observational

Summary: 
      Pain assessment using self-report scales (Visual Analogue Scale, Numerical Rating Scale), is
      recommended in the general population, however it is not always possible in patients with
      altered neurological status such as sedated patients or patients with delirium. Consequently,
      pain assessment is highly challenging in these ICU patients. This is a prospective
      observational study assessing 3 behavioral pain scales in the ICU.

      The hypothesis of this proposal is that one of the three ICU pain scales has a more important
      reliability than the others. Such a scale could be recommended to be used to measure pain
      intensity in ICU patients not able to communicate.
    

Detailed description: 
      The aims of this observational study are to measure and compare the psychometric properties
      of Behavioral Pain Scale (BPS), Critical Care Pain Observation Tool (CPOT) and Non Verbal
      Pain Scale (NVPS) at baseline and following repositioning procedure in the ICU
    

Intervention name(s): Repositioning
Intervention type(s): Procedure
Intervention description(s): pain assessment at baseline then following routine care repositioning in bed
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Intensive Care Unit patients
Prize Reinforcement Contingency Management for Cocaine Dependence: a 24-week Randomized Controlled Trial
Condition: Cocaine-related Disorders
MeSH terms: Cocaine-Related Disorders
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether prize-based contingency management
      (prizeCM) combined with cognitive behavioral therapy (CBT) is more effective in the treatment
      of of cocaine-dependent patients compared to CBT only. Patients were randomized to prizeCM +
      CBT (experimental group) or to CBT (control group) an treated over 24 weeks. It is the first
      trial of this type in Europe.
    


Intervention name(s): Cognitive behavioral therapy (CBT)
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Physical Workload Identify in Chest Compression Position Using Surface Electromyogram
Condition: Cardiopulmonary Resuscitation; Cardiac Arrest
MeSH terms: Heart Arrest
Study type: Interventional

Summary: 
      The chest compression depth decreases over time after starting continuous chest compression
      due to the rescuers' fatigue.

      The investigators hypothesized that the frequency parameters from surface electromyogram from
      each muscle during chest compression may reflect the muscle fatigue of the rescuers.

      Then investigators can identify which of the body are mainly used and get tired by continuous
      chest compression using surface electromyogram.
    


Intervention name(s): chest compression with kneeling position; chest compression with standing position
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Effects of Latanoprost on Choroidal Blood Flow Regulation in Human Subjects
Condition: Ocular Physiology; Intraocular Pressure; Regional Blood Flow
Study type: Interventional

Summary: 
      Latanoprost is a synthetic prodrug of 17-phenyl-substituted prostaglandin F2α analog. Used at
      a dose of one drop per day, it has been reported to produce a 30 to 35% reduction in
      intraocular pressure. Its mechanism of activation involves augmentation of the eye's natural
      uveoscleral outflow capacity .

      There is evidence that ocular blood flow plays a role in the clinical course of glaucoma.
      Glaucoma medication that lowers IOP simultaneously increases ocular blood perfusion pressure,
      which in turn may increase ocular blood flow.

      This could well contribute to the partially contradicting results concerning ocular
      hemodynamic effects of latanoprost. In vitro studies indicate that latanoprost has no effect
      on ocular vascular tone in therapeutical doses. By contrast, it has been reported in several
      studies that latanoprost 0.005% increases pulsatile ocular blood flow in patients with
      primary open angle glaucoma and normal tension glaucoma. This increase in pulsatile ocular
      blood flow mainly reflects an increase in the choroidal circulation.

      Little is known about the potential effect of latanoprost on choroidal blood flow regulation
      in humans. The present study therefore tries to elucidate whether treatment with latanoprost
      may alter choroidal blood flow regulation during artificial changes in ocular perfusion
      pressure. In addition, the present study aims to clarify whether the change in choroidal
      blood flow after latanoprost administration are due to direct vasoactive effects or due to
      the increase in ocular perfusion pressure. The second alternative may have important
      implications on our understanding of glaucoma treatment, because reduction of IOP may then
      per se result in normalization of ocular blood flow regulation.
    


Intervention name(s): Latanoprost 0.005%, Xalatan®; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Substance: Latanoprost 0.005%, Xalatan® (Pharmacia Austria Ges.m.b.H. Oberlaaer Straße 251, 1101 Vienna) Dosage form: topical application in one eye Dosage: 1 drop in the evening for 14 days; Substance: Vehicle to latanoprost (eyedrops containing the same stabilizers as latanoprost, but no active drug) Dosage form: topical application in one eye Dosage: 1 drop in the evening for 14 days
Intervention MeSH terms: Latanoprost
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Diagnostic
Keywords: Latanoprost; Choroidal Blood Flow; Intraocular Pressure
Intra Incisional Infiltration of Bupivacaine Versus Meloxicam on Post Cesarean Section Pain Relief
Condition: Cesarean Section Pain
Study type: Interventional

Summary: 
      Investigation: compare the effect of local infiltration of incision site with bupivacaine and
      local infiltration with meloxicam in women undergoing cesarean sections on postoperative pain
      relief and analgesic requirement.

      Condition: post cesarean sections analgesia intervention: infiltration of incision
      bupivacaine versus meloxicam Phase: Not applicable
    

Detailed description: 
      study type: randomized clinical trial actual enrollment: 119 allocation: Random intervention
      model: three groups assignment masking: open lebal primary purpose: pain relief after
      Cesarean section actual study start: March 3, 2019 Primary Completion: March 5, 2020 actual
      study completion date: May 9, 2020
    

Intervention name(s): local ifiltration Bupivacaine, Meloxican and placebo
Intervention type(s): Drug
Intervention description(s): no other intervention done
Intervention MeSH terms: Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Group A (bupivacaine group): included 35 patients in which and subcutaneous tissue (upper and lower flaps) were infiltrated with 20 ml of 0.25% bupivacaine hydrochloride. (Marcaine, 25% vial, Astra Zeneca) diluted in 20 ml of 0.9% saline.
Group B (meloxicam group): included 35 patients in which and subcutaneous tissue (upper and lower flaps) were infiltrated with meloxicam 15mg (Anticox 2 ampoule 15mg/3ml, ADWIA Pharmaceuticals). diluted in 20 ml of 0.9% saline.
Group C (placebo group): included 35 patients in which skin and subcutaneous tissue was infiltrated with 20 ml 0.9% saline.
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Prevention
Pet Ownership and Glucose Control in Type 1 Diabetes
Condition: Type 1 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Interventional

Summary: 
      The investigators' long-term goal is to discover novel, inexpensive and feasible strategies
      to improve the management and well-being of youth with T1DM. The specific objective of this
      proposal is to quantify the impact of responsible pet ownership on the glycemic control and
      health related quality of life in youth with T1DM.
    

Detailed description: 
      Type 1 diabetes mellitus (T1DM) affects 151,000 children and adolescents in the United
      States. Youth with T1DM are at a high risk for multiple psychosocial co-morbidities including
      poor health related quality of life (HRQoL) which is linked to medication non-compliance and
      increased risk for diabetes-related complications. Any reduction in the psychosocial
      adjustment difficulties related to T1DM could improve the medical outcome of children with
      T1DM.

      Current standards for diabetes management reflect the need to maintain glucose control within
      a normal range. However, numerous reports indicate that normalization of blood glucose levels
      is seldom attainable in children and adolescents. Family cohesion, positive coping
      strategies, younger age of onset, social support and adequate self-regulatory behavior are
      found to favorably influence glycemic control. One may conclude that the presence of a
      companion animal, capable of enhancing the positive factors named above, would augment the
      array of tools available for the successful management of chronic illnesses such as T1DM.

      There is a lack of studies assessing the impact of pet ownership on the health and well-being
      of adolescents. The process of caring for, loving and being loved by a companion animal could
      offer direct and/or indirect benefits to the HRQoL in children with T1DM. To the
      investigators' knowledge, there are no studies examining the impact of pet ownership on
      glycemic control and HRQoL in youth with T1DM.
    

Intervention name(s): Pet Fish; Picture of a fish
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Participants will receive a betta fish and the supplies to care for the fish for a one year time period.; Participants will receive a picture of a betta fish.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: adolescence; self care
CHO(E)P-14 Followed by Alemtuzumab Consolidation in Peripheral T Cell Lymphoma
Condition: Peripheral T-Cell Lymphoma
MeSH terms: Lymphoma; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral
Study type: Interventional
Phase: Phase 2

Summary: 
      Prospective Phase II Study for Treatment Peripheral T-cell Lymphoma, CHOP-14 Plus
      PEG-Filgrastim Followed by Alemtuzumab Consolidation
    

Detailed description: 
      Peripheral T cell lymphoma patients of all subtypes according to WHO are treated with an
      induction of 6 cycles of CHOP-etoposide-14 (if below 60 years of age) oder CHOP-14. If at
      least a PR is reached, consolidation with alemtuzumab, total dose 133 mg, is given i.v.
    

Intervention name(s): Alemtuzumab
Intervention type(s): Drug
Intervention description(s): Consolidation after CHOP induction
Other intervention name(s): MabCampath
Intervention MeSH terms: Alemtuzumab
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: peripheral T cell lymphoma; alemtuzumab; consolidation
Effects of Zoledronic Acid and Raloxifene on Bone Turnover Markers in Postmenopausal Women With Low Bone Mineral Density
Condition: Osteoporosis
MeSH terms: Osteoporosis; Bone Diseases, Metabolic
Study type: Interventional
Phase: Phase 4

Summary: 
      This study will compare the effects of Zoledronic acid and Raloxifene in reducing bone
      turnover markers in postmenopausal women with low bone mineral density over 6 months.
    


Intervention name(s): Raloxifene; Zoledronic acid; Placebo oral pills; Placebo intravenous (i.v.) infusion
Intervention type(s): Drug; Drug; Drug; Drug
Other intervention name(s): Reclast, Aclasta
Intervention MeSH terms: Zoledronic Acid; Raloxifene Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Osteoporosis; Post-menopausal; Bone mineral density
Nerve Transfer After Spinal Cord Injuries
Condition: Spinal Cord Injury
MeSH terms: Spinal Cord Injuries; Wounds and Injuries
Study type: Interventional

Summary: 
      Nerve Transfer surgery can provide improved hand function following cervical spinal cord
      injuries
    

Detailed description: 
      Current treatment strategies of acute cervical spinal cord injuries remain limited. Treatment
      options that provide meaningful improvements in patient quality of life and long-term
      functional independence will provide a significant public health impact.

      Specific Aim: Measure the efficacy of nerve transfer surgery in the treatment of patients
      with complete cervical spinal cord injuries with no hand function. Optimize the efficiency of
      nerve transfer surgery by evaluating patient outcomes in relation to patient selection and
      optimal timing the the surgery.

      Hypothesis: Peripheral nerve transfers in patients with spinal cord injuries will improve
      hand function and provide improvement in patient quality of life and functional independence.
    

Intervention name(s): Nerve Transfer
Intervention type(s): Procedure
Intervention description(s): A nerve transfer procedure will be individualized to each patient's functional deficit.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Spinal cord injury; nerve transfer; tetraplegia; quadriplegia
Comparison of Deferiprone Extended Release Tablets and Ferriprox Immediate Release Tablets in Healthy Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to look at the pharmacokinetics of a new formulation of
      deferiprone (deferiprone extended release tablets) under fed and fasting conditions.
    

Detailed description: 
      This is a single-center, open-label, randomized, 5-period, 5-sequence study of the
      pharmacokinetics of a new formulation of deferiprone, extended release tablets, in twenty
      healthy volunteers. In each study period, blood samples for pharmacokinetics assessment will
      be collected pre-dose and over 24 hours post-dose. Safety will be assessed throughout the
      study.
    

Intervention name(s): Deferiprone extended release; Deferiprone immediate release
Intervention type(s): Drug; Drug
Intervention description(s): Deferiprone 1000 mg extended release tablet formulation; Ferriprox (deferiprone) 500 mg immediate release tablet formulation
Other intervention name(s): Deferiprone extended release tablet formulation; Ferriprox immediate release tablet formulation
Intervention MeSH terms: Deferiprone
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: deferiprone; deferiprone extended release formulation; pharmacokinetics
Atorvastatin as GVHD Prophylaxis for Allogeneic Hematopoietic Cell Transplantation
Condition: Graft vs Host Disease
MeSH terms: Graft vs Host Disease
Study type: Interventional
Phase: Phase 2

Summary: 
      Hematopoietic stem cell transplantation is a procedure in which a person receives blood
      forming stem cells from a person called a "donor." The stem cells can be obtained from the
      hollow part of the hip bone or from blood.

      A serious problem with this treatment is graft-versus-host disease (GVHD). This happens when
      stem cells from the donor attack normal cells of the recipient. Currently, there is no
      universal standard of care in the United States to prevent GVHD.

      This study is being done to see if a medicine that is used to lower cholesterol can also help
      in reducing GVHD.

      Patients will receive atorvastatin daily by mouth starting 14 days before stem cell
      transplant. They will continue to take atorvastatin until 180 days after transplant. This
      medicine may be stopped earlier if there is a bad side effect or a severe GVHD. Patients will
      also receive standard treatment to prevent GVHD. Patients will undergo many tests that are
      standard for their treatment at West Virginia University (WVU), including blood tests to
      check blood counts, kidney function and HIV status; blood test to check for pregnancy; Multi
      Gated Acquisition Scan (MUGA scan)or echocardiogram to test heart function; lung function
      testing; and bone marrow aspirate or biopsy. Patients will also have the option to provide
      blood samples for optional research related to the study.
    

Detailed description: 
      Acute graft-versus-host disease (GVHD) is one of the most frequent complications after
      allogeneic hematopoietic stem cell transplantation (HSCT).(1) It develops in 30-75% of
      recipients of allogeneic HSCT depending on the degree of histocompatibility between the donor
      and the recipient, number of T-cells in the graft, recipient's age and GVHD prophylactic
      regimen used. (2-4) Novel strategies designed to effectively prevent the development of this
      life threatening complication of allogeneic transplantation are urgently needed.
    

Intervention name(s): Atorvastatin calcium
Intervention type(s): Drug
Intervention description(s): 40 mg PO daily
Other intervention name(s): Lipitor
Intervention MeSH terms: Atorvastatin; Calcium
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Graft vs Host Disease; GVHD; Allogeneic hematopoietic stem cell transplantation; HSCT; Atorvastatin
Identifying Vitamin D Deficiency in Very Low Birth Weight Infant (VLBW) Infants Part 2
Condition: Infant, Very Low Birth Weight; Calcium Deficiency; Vitamin D Deficiency
MeSH terms: Vitamin D Deficiency; Birth Weight
Study type: Interventional

Summary: 
      This study is to determine the amount of vitamin D required for a very low birth weight
      infant to reach vitamin D sufficiency and achieve optimal calcium health and bone growth.
    


Intervention name(s): 400 IU Cholecalciferol- Vitamin D Daily
Intervention type(s): Dietary Supplement
Intervention description(s): Infants who are defined as vitamin D deficient at birth will be randomized to receive either 400 IU vitamin D/day or placebo daily until term age is reached.
Intervention MeSH terms: Vitamin D; Cholecalciferol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: vitamin D; preterm infants; calcium; bone; parathyroid hormone
Assessment of V0018 2.5 mg Effect on Craving
Condition: Healthy Highly Dependant Smokers
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate the reduction of craving and its time course after
      administration of V0018 2.5 mg compared to placebo in healthy highly dependant smokers.
    


Intervention name(s): V0018; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Oromucosal - Single dose; Oromucosal - Single dose
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Nicotine replacement therapy; craving
Efficacy and Safety of AD-MSCs Plus Calpocitriol Ointment and PSORI-CM01 Granule in Psoriasis Patients
Condition: Mesenchymal Stromal Cells; Psoriasis; Drug Effect; Drug Toxicity
MeSH terms: Psoriasis; Drug-Related Side Effects and Adverse Reactions
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the efficacy and safety of Adipose derived
      Mesenchymal Stem Cells (AD-MSCs) plus Calpocitriol Ointment and PSORI-CM01 Granule with
      moderate to severe psoriasis. Any adverse events related to AD-MSCs infusion will be
      monitored.The primary outcome is the reduction rate of PASI(Psoriasis Area and Severity
      Index) and treatment response will be computed from PASI before and after treatment.
    

Detailed description: 
      The purpose of this study is to evaluate the efficacy and safety of Adipose derived
      Mesenchymal Stem Cells (AD-MSCs) plus Calpocitriol Ointment and PSORI-CM01 Granule with
      moderate to severe psoriasis. Any adverse events related to AD-MSCs infusion will be
      monitored.The primary outcome is the reduction rate of PASI(Psoriasis Area and Severity
      Index) and treatment response will be computed from PASI before and after treatment.
    

Intervention name(s): Calcipotriol ointment; PSORI-CM01 Granule; adipose-derived multipotent mesenchymal stem cells
Intervention type(s): Drug; Drug; Biological
Intervention description(s): The topical treatment in the study was calcipotriol ointment(Dovonex;LEO Laboratories Ltd, Ireland) twice daily for 12 weeks.; PSORI-CM01#YXBCM01# granule 5.5g os once a day for 12weeks.; AD-MSCs(adipose-derived multipotent mesenchymal stem cells) were infused intravenously at a dose of 2 million cells/kg
Other intervention name(s): Dovonex; Chinese Herbal Medicine
Intervention MeSH terms: Calcipotriene
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment