bioihbjkbjnl/mcl2 huggingface dataset:
The Model and Effect Assessment of Training General Practitioner for Dementia Early Recognition
Condition: Dementia
MeSH terms: Dementia
Study type: Interventional

Summary: 
      With the number of aged people increasing and the lifespan lengthen, dementia is becoming a
      great public challenge in China. Early recognition of dementia is crucial to improve the
      prognosis of dementia patients and decrease the society disease burden. It is a pity that the
      early recognition rate of dementia is less than 7% in China. Most of the aged people live in
      the community and general practitioners (GP) in community provide health service much more
      frequently than other medical workers. It is suggested that GPs should be the best one to
      screen dementia in its early period. However, most of GPs have not receive any training about
      dementia early recognition in China. It is imperative and meaningful to provide training to
      GPs for improve GPs' knowledge and skills about dementia early recognition. How to train GPs
      for early recognizing dementia and how about the training effect? Which training model may be
      better? We did not find consistent conclusion about these questions in China. This study aims
      to set up an effective and convenient model to training GPs in dementia early recognition. A
      total of 152 GPs in Beijing will be enrolled and be randomly divided into two groups. One
      group will firstly have lessons about dementia early recognition and then receive
      face-to-face supervision and key messages by Wechat about dementia early recognition once a
      month in the following 6 months. Another group will firstly have lessons about dementia early
      recognition and then receive face-to-face supervision and key messages by Wechat about
      dementia early recognition once a month in the following 3 months. The score of knowledge and
      attitude about dementia early recognition, the accuracy of analyzing dementia cases, the
      usage of dementia screening scales and the referral rate of dementia will be evaluated at
      different time point respectively. This study will provide evidence for training GPs
      effectively in dementia early recognition in the future and will promote dementia early
      recognition in community.
    


Intervention name(s): lessons,long-term supervision and message; lessons,short-term supervision and message
Intervention type(s): Other; Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Health Services Research
Keywords: dementia; early recognition; general practitioner; training
Bevacizumab and Aldesleukin in Treating Patients With Metastatic Clear Cell Carcinoma of the Kidney
Condition: Kidney Cancer
MeSH terms: Carcinoma; Kidney Neoplasms
Study type: Interventional
Phase: Phase 2

Summary: 
      RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different
      ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and
      help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the
      growth of tumor cells by blocking blood flow to the tumor. Biological therapies, such as
      aldesleukin, may stimulate the immune system in different ways and stop tumor cells from
      growing. Giving bevacizumab together with aldesleukin may kill more tumor cells.

      PURPOSE: This phase II trial is studying how well giving bevacizumab together with
      aldesleukin works in treating patients with metastatic clear cell carcinoma of the kidney.
    

Detailed description: 
      OBJECTIVES:

      Primary

        -  To evaluate the effect of the combination of bevacizumab and aldesleukin on
           progression-free survival of patients with good- or intermediate-risk metastatic clear
           cell renal cell carcinoma.

      Secondary

        -  To determine the objective response rate in patients receiving this regimen.

        -  To determine the time to progression in patients receiving this regimen.

        -  To evaluate immunomodulatory effects of this regimen in patients

        -  To evaluate the toxicity of this regimen in these patients.

      OUTLINE: Patients receive bevacizumab IV over 30-90 minutes on days -14, 1, 15, 29, and 42
      and aldesleukin subcutaneously on days 1-5, 8-12, 15-19, 22-26, 29-33, and 36-40. Courses
      repeat every 8 weeks for up to 1 year in the absence of disease progression or unacceptable
      toxicity. Patients achieving complete response after completion of study therapy may receive
      1 additional course of therapy.

      After completion of study therapy, patients are followed periodically.
    

Intervention name(s): aldesleukin; bevacizumab
Intervention type(s): Biological; Biological
Intervention description(s): SQ Aldesleukin (Days 1-5) Monday through Friday for six weeks followed by a two-week break.; Bevacizumab will be administered on day -14, then on day 1 and every 2 weeks thereafter (days 1, 15, 29, and 42) in a continuous manner.
Other intervention name(s): rIL-2 (NSC3773364); Proleukin®; Chiron
Intervention MeSH terms: Aldesleukin; Bevacizumab
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: clear cell renal cell carcinoma; recurrent renal cell cancer; stage IV renal cell cancer
Capecitabine and Cisplatin (XP)+Sorafenib in Advanced Gastric Cancer (AGC): Sorafenib+XP
Condition: Advanced Gastric Cancer
MeSH terms: Stomach Neoplasms
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      There is strong scientific rationale for exploring the role of sorafenib with capecitabine
      and cisplatin (XP) in AGC. XP is a new standard of care in AGC and sorafenib is a novel
      signal transduction inhibitor that prevents tumor cell proliferation and angiogenesis through
      blockade of the Raf/MEK/ERK pathway at the level of Raf kinase and the receptor tyrosine
      kinases VEGF-R2 and PDGFR-beta.
    


Intervention name(s): Capecitabine, Cisplatin, Sorafenib
Intervention type(s): Drug
Intervention description(s): Capecitabine ( ) mg/m2 bid D1-D15 Cisplatin 80 mg/m2 D1 Sorafenib ( ) mg bid PO daily every 3 weeks
Intervention MeSH terms: Capecitabine; Sorafenib
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Gastric cancer; capecitabine; cisplatin; sorafenib; phase I; phase II
Magnetic Resonance Imaging of the Coronary Vessel Wall
Condition: Coronary Artery Disease
MeSH terms: Coronary Artery Disease
Study type: Observational

Summary: 
      Despite advances in prevention and treatment, clinical manifestations of atherosclerosis
      (e.g. myocardial infarction, stroke) remain the largest cause of mortality in the Western
      world. The occurrence of acute ischemic syndromes, including unstable angina and myocardial
      infarction, is highly associated with atherosclerotic plaque morphology.

      Magnetic resonance (MR) imaging is able to noninvasively depict the lumen of coronary
      arteries without the need for ionizing radiation. In addition, MR imaging is able to generate
      soft-tissue contrast unlike any other imaging modality. It has been shown in the aorta and
      carotid artery that MR imaging is able to identify different atherosclerotic plaque
      components in vivo. Similar MR imaging techniques are becoming available to visualize the
      coronary arterial wall and preliminary studies have shown the feasibility of MR coronary
      vessel wall imaging in humans.

      The overall aim of the current study is to identify in vivo MR coronary vessel wall and
      plaque features that are associated with acute coronary syndromes. This study is divided into
      2 substudies:

        1. Detection of atherosclerosis in the coronary vessel wall with contrast-enhanced MR
           imaging in patients with coronary artery disease and age-matched healthy volunteers.

        2. Characterization of coronary vessel wall plaque morphology in patients with stable and
           unstable angina: validation of MRI with the current standard of reference intravascular
           ultrasound (IVUS).
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        -  Patients with (un)stable angina or non-st-elevated myocardial infarction: sample from
             dept. of cardiology

          -  healthy volunteers: community sample
      
Keywords: coronary atherosclerosis; magnetic resonance imaging; vulnerable plaque
The Prevention Options for Women Evaluation Research (POWER) Cohort
Condition: HIV/AIDS
MeSH terms: Acquired Immunodeficiency Syndrome; HIV Infections
Study type: Observational

Summary: 
      The POWER Cohort study is a PrEP implementation project to demonstrate Pre-exposure
      prophylaxis (PrEP) delivery for young women in Cape Town and Johannesburg, South Africa and
      Kisumu, Kenya.
    

Detailed description: 
      PrEP will be delivered to young women according to emerging national guidelines in family
      planning clinics (Kisumu, Kenya), youth friendly clinics (Johannesburg, South Africa), and
      mobile youth friendly clinics (Cape Town, South Africa). The investigators will evaluate PrEP
      delivery and follow cohorts of young women at each clinic location to understand PrEP uptake
      and use. In the Kisumu clinics, the investigators will also offer expedited partner therapy
      and partner HIV self-tests to women who test positive for chlamydia and/or gonorrhea. At one
      clinic in Johannesburg, the investigators will evaluate the use of a decision support tool to
      improve the decision to initiate PrEP.
    

Intervention name(s): Truvada
Intervention type(s): Drug
Intervention description(s): A fixed dose of oral co-formulated tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) will be used as PrEP.
Intervention MeSH terms: Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Sexually active HIV uninfected women ages 16-25 will be recruited from family planning
        clinics, youth clinics, and youth outreach programs.
      
Biospecimen description: 
      Dried blood spots
    
Keywords: pre-exposure prophylaxis; young women; delivery of health care; HIV infections/prevention
Rebif Advanced Magnetic Resonance Imaging (MRI) and Immunology Pilot Trial
Condition: Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Sclerosis
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this trial is to evaluate the effects of Rebif® 44 mcg subcutaneous (sc) three
      times a week (tiw) on a) remyelination/demyelination, b) lesion and brain volume, c) central
      nervous system (CNS) iron deposition, and d) immune status in subjects with
      relapsing-remitting multiple sclerosis (RRMS) RRMS via several MRI techniques.
    


Intervention name(s): Rebif
Intervention type(s): Drug
Intervention description(s): 44 mcg tiw
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Efficacy and Safety of Once-Daily Atomoxetine Hydrochloride in Adults With ADHD Over an Extended Period of Time (6 Months)
Condition: ADHD
Study type: Interventional
Phase: Phase 4

Summary: 
      A study to compare the effect of once-daily atomoxetine versus placebo in treating symptoms
      of ADHD in adults for up to 6 months.
    


Intervention name(s): Atomoxetine Hydrochloride; placebo
Intervention type(s): Drug; Drug
Intervention MeSH terms: Atomoxetine Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Assess the Efficacy and Safety of ASC-01 in Patients With Major Depressive Disorder
Condition: Major Depressive Disorder
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 3

Summary: 
      To evaluate the efficacy and the safety of ASC-01 (aripiprazole/sertraline combination)
      compared to sertraline monotherapy in patients with major depressive disorders who have
      responded incompletely to sertraline monotherapy.
    


Intervention name(s): ASC-01; Placebo
Intervention type(s): Drug; Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Computer-Based ED Intervention to Improve Pediatric Asthma Medicine Adherence
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional

Summary: 
      Asthma is common in children and impacts their health. There are effective medications for
      improving asthma, but some families have difficulty using medicines on a regular basis. This
      study in the emergency department will improve medicine use for children 2-12 years-old with
      asthma by developing content for a customized, tablet-based electronic intervention. A
      clinical trial will then be used to compare asthma outcomes for this intervention with
      routine asthma care.
    

Detailed description: 
      The investigators have used focus groups to get ideas from parents of children with asthma to
      best design the intervention. This has helped us create the questions that are being used in
      the intervention, and make the computer program appealing and acceptable to parents of
      children with asthma.

      The investigators will study the success of the intervention for children who receive it
      compared to children who obtain routine emergency department care. Participants who receive
      the intervention will complete a series of questions on a tablet computer. Questions will
      guide creation of individualized education and advice to improve medication use for each
      participant. The intervention will also allow for customized communication with each child's
      primary care provider. The investigators will include educational boosters at 2 and 4 weeks
      after the intervention delivered as chosen by the participant (email / text / RSS / mail).
      Children in the routine asthma care arm will not receive the intervention, and instead will
      receive routine discharge instructions by the emergency room doctors.

      The investigators will compare the success of the intervention group to routine emergency
      department care by using a device (DOSER CT) that measures daily administered doses of
      medicine. Data from the DOSER CT will be collected monthly at home visits for three months.
      The investigators will also measure health care use and quality-of-life for each child using
      a survey at these home visits. The investigators believe that the intervention will improve
      doses of medicine given, reduce unnecessary health care use, and improve children's quality
      of life.
    

Intervention name(s): Asthma Medication Adherence Education
Intervention type(s): Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Other
Keywords: Asthma; Medication adherence; Intervention study
A Study Investigating the Movement of Lu AG09222 Into, Through, and Out of the Body of Healthy Caucasian, Chinese, and Japanese Participants
Condition: Migraine
Study type: Interventional
Phase: Phase 1

Summary: 
      The main goal of the study is to learn more about how the body absorbs and eliminates Lu
      AG09222 after a single dose is injected under the skin. Researchers will also investigate
      safety and tolerability effects of Lu AG09222 after administration.
    


Intervention name(s): Lu AG09222; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Lu AG09222 will be administered per schedule specified in the arm description.; Placebo matching to Lu AG09222 will be administered per schedule specified in the arm description.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Clinical Evaluation of Subgingival Open Sandwich Restorations
Condition: Dental Restoration Failure of Marginal Integrity
Study type: Interventional

Summary: 
      This study was designed to evaluate and compare the 3-year periodontal responses and clinical
      performance of proximal subgingival open sandwich restorations using three different glass
      ionomer-based restorative materials and flowable composite.
    

Detailed description: 
      The description of the experimental design followed the Consolidated Standards of Reporting
      Trials (CONSORT) statement. The present study was a double-blinded (patients and examiner)
      randomized clinical trial anticipating the parallel design. Ninety-five adult patients
      seeking dental treatment in the Operative Department clinic at the Faculty of Dentistry,
      University of Mansoura were enrolled in the current study with a total of 120 Class II
      restorations. No advertisement was made for participant recruitment, forming a sample of
      convenience. Each patient must signs a consent form before participating in the current
      study. The study was conducted from January 2020 to January 2023 as a part of the Doctoral
      dissertation. Mansoura University institution's ethics committee approved the form and
      protocol before conducting the study. The sample size was calculated based on the clinical
      success rate (100% success rate at 2 years) of posterior class II restorations restored with
      open sandwich and deep margin elevation techniques observed in previous studies. According to
      several parameters including a significance level of 5%, the power of the test was calculated
      to be 80%, and equivalent limit of 15%. Upon these data, a sample size of 120 subjects was
      appropriate to allow for a 20% drop-out.
    

Intervention name(s): Proximal box elevation using one of the tested materials
Intervention type(s): Other
Intervention description(s): Each patient randomly received deep proximal margin elevation with one of the tested restorative materials, while the overlying restorations were all the same regular bulk fill resin composite
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Each patient received one or two restorations in a posterior tooth on any side randomly selected from the 4 tested restorative materials, all materials were used according to manufacturers' instructions
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Deep margin elevation; Proximal box elevation; Open sandwich technique; Bi-layered restorations; Subgingival cervical margin
Internet Gaming Disorder and Psychiatric Disorder
Condition: Psychiatric Disorder
MeSH terms: Mental Disorders; Problem Behavior; Internet Addiction Disorder
Study type: Observational

Summary: 
      The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)
      recently identified Internet gaming disorder as a new potential psychiatric disorder which
      need further research. Several studies showed the important prevalence of psychiatric
      disorders among patients suffering from internet gaming disorder. Investigators hypothesize
      that on an other side the prevalence of internet gaming disorder among patients suffering
      from psychiatric disorders shall be high but it has never been studied yet.

      The main goal of this trial is to examine the prevalence of internet gaming disorder using
      the Internet Gaming Disorder Test-10 (IGDT-10) among inpatient aged from 12 to 17 of 4
      psychiatric units of French region Auvergne-Rhône-Alpes.

      Secondary goals will be to assess a parental version of the IGDT-10 (IGDT-10-P) and to
      compare the two versions.

      IGDT-10 will be passed during 6 months to every inpatient and IGDT-10-P to their parents
      within the 21 first days of the hospitalisation.
    


Intervention name(s): IGDT-10 self-administered questionnaire
Intervention type(s): Other
Intervention description(s): Patients and their parents will answer the French version of the IGDT-10 self-administered questionnaire (IGDT-10-P in the parents 'questionnaire).
The IGDT-10 is a self-administered questionnaire based on DSM-5 internet gaming disorder criteria and the IGDT-10-P is a parental version specially adapted from the IGDT-10 for this study.
Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patient aged from 12 to 17 of 4 psychiatric units of French region Auvergne-Rhône-Alpes and
        their parents.
Effects of DHEA and Exercise in the Elderly
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 3

Summary: 
      DHEA or dehydroepiandrosterone is a naturally occurring hormone secreted by tghe adrenal
      galnds. The secretion of HDEA declines with aging. DHEA is considered a food supplement and
      it is not regulated by the FDA. The purpose of this research is to evaluate ceratin of the
      biological effects of a reaplcement dose of DHEA. As you get older, DHEA levels are lower
      than you were younger. The replamcent dose is the dose of DHEA that will raise DHEA levesl to
      the levels found in young people. Anotehr purpose is to determine whether DHEA enhances the
      adaptations to an exercise training program.
    

Detailed description: 
      DHEA declines dramatically with age. Low DHEA levels have been found to correlate with
      sarcopenia and osteopenia. It is, therefore, postulated that many physiologic changes of
      aging are secondary to the decline in DHEA. Thus, the objective of the proposed research is
      to evaluate the effect of DHEA replacement on age-related changes in body composition, muscle
      function and metabolism, and bone mass in healthy older adults. The specific aims are to
      evaluate the effects of DHEA replacement (50 mg/d) alone, or in combination with resistance
      exercise training on: a) lean body mass, intraabdominal fat and thigh muscle volume, and
      muscle protein synthesis rate b) bone mineral density (BMD) of the total body, lumbar spine,
      and hip and biochemical markers of bone turnover and c) insulin sensitivity. It is
      hypothesized that DHEA administration will have additive or synergistic effects with
      exercise. Healthy but sedentary subjects , aged 65-78 years old, will be randomized to
      receive either DHEA, 50 mg/d, or placebo and to participate in either supervised or home
      exercise training programs. The supervised exercise program will consist of resistance
      training designed to increase muscle mass, strength, and bone mass, and decrease fat mass.
      The goal of this research is to provide information on the potential role of DHEA replacement
      therapy in maintaining the physical health and functional capacity of older people
    

Intervention name(s): DHEA; exercise
Intervention type(s): Drug; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Aging, dhea, bone density, muscle mass, insulin action