Miswak Efficacy Compared With Chlorhexidine
Condition: Gingivitis
MeSH terms: Gingivitis
Study type: Interventional
Phase: Early Phase 1

Summary: 
      Gingivitis is a form of gum disease and is elicited by the accumulation of plaque on the
      tooth and the soft-tissue adjoining the tooth. Mouthwashes containing chemical or herbal
      substances are adjunctive tools in improving oral hygiene. Miswak mouthwash is a herbal
      mouthwash. Chlorhexidine mouthwash is the most efficient antimicrobial and antiplaque agent.
      The aim of the study is to assess the effectiveness of the miswak mouthwash with 0.12%
      chlorhexidine. This study was a blind randomized clinical trial.

      Materials and Methods: A total of 60 patients aged (20-55) years old who attended the
      Periodontics Clinics at College of Dentistry, Al-Iraqia University were allocated for use the
      mouthwash either miswak mouthwash or 0.12% chlorhexidine gluconate Kin Gingival®
      (Laboratorios KIN, Spain) twice daily (once in the morning and one before bedtime) for seven
      days. Gingival, bleeding, and plaque indices were recorded at baseline and after 7 days of
      treatment.
    

Detailed description: 
      Gingivitis is the mildest form of gum disease and is elicited by the accumulation of plaque
      on the tooth and the soft-tissue adjoining the tooth. Accumulation of dental biofilm has been
      established as the initial cause of this disease. It is determined by redness of the gum
      margins, edema, bleeding upon brushing, and loss of periodontal attachment loss. Gingivitis
      exists in both acute and chronic forms. Acute gingivitis is identified as trauma,
      micro-organisms, and specific infections while chronic inflammation is related to bacterial
      biofilm which covers the gum and adjoining the teeth. Elimination and control of plaque are
      very important in the maintenance of periodontal health. Chlorhexidine mouthwash has is a
      tremendous effect when it is used as a mouthwash for a long time; therefore, the Food and
      Drug Administration (FDA) recommends limiting the use of chlorhexidine mouthwash up to 6
      months to minimize or limit its side effects. Additionally, the World Health Organization
      (WHO) encouraged to consider the possible use of herb extracts and natural plants mouthwashes
      instead of chemical mouthwash just as miswak mouthwash. Miswak mouthwash is a herbal
      mouthwash that is available locally and culturally accepted. It is prepared from a plant
      called Salvadora persica which comes from a tree (Arak) that grows in Africa and west India.
    

Intervention name(s): Miswak mouthwash group; Chlorhexidine gluconate mouthwash
Intervention type(s): Drug; Device
Intervention description(s): Twice daily for seven days for two months; Twice daily for seven days for two months
Other intervention name(s): chlorhexidine gluconate Kin Gingival®
Intervention MeSH terms: Chlorhexidine; Chlorhexidine gluconate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: Miswak; chlorhexidine; mouthwash; gingivitis; oral health