Effect of Intradialytic Continuous Versus Interval Aerobic Exercises on Quality of Life in Patients With Chronic Renal Failure.
Condition: Chronic Kidney Diseases
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Failure, Chronic
Study type: Interventional

Summary: 
      Chronic kidney disease has emerged as one of the leading causes of mortality worldwide, and
      it is one of a small number of non-communicable diseases that have shown an increase in
      associated deaths over the past 2 decades. The high number of affected individuals and the
      significant adverse impact of chronic kidney disease should prompt enhanced efforts for
      better prevention and treatment.

      Chronic kidney disease is a serious medical problem, as it is associated with high risks of
      complications which lead to poor quality of life and physical capacity.
    

Detailed description: 
      Sixty-four patients undergoing haemodialysis randomly be allocated into three groups, (A, B &
      C). Group A (low- to moderate-continuous intensity cycling exercises, group B (moderate- to
      high-interval intensity cycling exercises), the exercises performed two sessions per week for
      two months and group (C)Twenty two patients received the hemodialysis sessions only.

      Group A (low- to moderate-continuous intensity cycling exercises:

      Twenty two patients performed aerobic exercise during dialysis using Pedal machine at low- to
      moderate continuous intensity rating from 11 to 13 on the Borg scale for 15-30 minutes.

      warming up and cool down (approximately 10 minutes) in form of free active exercise of the
      lower extremities.

      Group B (moderate- to high-interval intensity cycling exercises), Twenty patients performed
      aerobic exercise during dialysis using Pedal machine at moderate-to-high interval intensity
      rating from 12 to 15 on the Borg scale for 15-30 minutes.

      warming up and cool down (approximately 10 minutes) in form of free active exercise of the
      lower extremities.

      Inclusion Criteria:

        1. Sixty four patients of both sexes

        2. Age will range from 35-55 years old.

        3. BMI will be from 25-34.5 Kg/m2.

        4. All patients with stage 5 of CRF.

        5. All patients are stable on dialysis for at least six months before the study.

        6. Stable medical and clinical hemodynamic state.

      Exclusion criteria:

        1. Patients with hearing impairment or mental disorder.

        2. Patients with unstable angina, uncontrolled cardiac arrhythmia, decompensated heart
           failure, persistent systolic blood pressure (BP) greater than 200 mmHg, persistent
           diastolic BP greater than 120 mmHg, acute pericarditis or myocarditis.

        3. Patients with auto-immune diseases.

        4. Chronic inflammatory orthopedic disorders and rheumatoid arthritis.

        5. Patients with history of neuromuscular disease (muscular dystrophy, myasthenia gravis,
           myopathy, multiple sclerosis and peripheral neuropathy).

        6. Patients with chronic obstructive lung disease, restrictive lung disease or chronic
           chest infection.

        7. Patients with BMI > 35Kg/m2.
    

Intervention name(s): low- to moderate-continuous intensity cycling exercises:; moderate- to high-interval intensity cycling exercises; hemodialysis sessions only
Intervention type(s): Other; Other; Other
Intervention description(s): aerobic exercise during dialysis using Pedal machine at low- to moderate continuous intensity rating from 11 to 13 on the Borg scale for 15-30 minutes.
warming up and cool down (approximately 10 minutes) in form of free active exercise of the lower extremities; aerobic exercise during dialysis using Pedal machine at moderate-to-high interval intensity rating from 12 to 15 on the Borg scale for 15-30 minutes.
warming up and cool down (approximately 10 minutes) in form of free active exercise of the lower extremities; hemodialysis sessions only
Other intervention name(s): low- to moderate-continuous aerobic exercise
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Sixty-four patients undergoing haemodialysis randomly be allocated into three groups, (A, B & C). Group A (low- to moderate-continuous intensity cycling exercises, group B (moderate- to high-interval intensity cycling exercises), the exercises performed two sessions per week for two months and group (C) received the hemodialysis sessions only.
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Intradialytic cycling exercise, function capacity, hemodialysis, quality of life.