Evaluatıon of Nutrıtıonal Status and Total Antıoxıdant Capacıty in Osteoarthritis
Condition: Osteoarthritis, Knee
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Observational

Summary: 
      This is a descriptive cross-sectional study conducted to evaluate the nutritional status and
      total antioxidant/oxidant capacity of individuals diagnosed with osteoarthritis.
    

Detailed description: 
      The aim of this study is to determine the nutritional status of individuals diagnosed with
      osteoarthritis, to evaluate dietary total antioxidant/oxidant capacity and serum total
      antioxidant/oxidant capacity, and to examine the relationship of total antioxidant capacity
      with anthropometric measurements and nutritional status.

      The study will include adult individuals diagnosed with osteoarthritis who applied to the
      Physical Therapy and Rehabilitation polyclinics of Ankara City Hospital. After the
      individuals fill out the questionnaire containing information about their socio-demographic
      characteristics, nutritional habits and physical activity levels, the researchers will take
      the food consumption records and the frequency of food consumption with a 24-hour reminder
      method. The total antioxidant amount of the diet will be determined from the food consumption
      records of the individuals. In addition to these, anthropometric measurements of individuals
      such as height, body weight and waist circumference will also be taken by the researchers.

      In the study, routine biochemical parameter will be recorded from patient files and serum
      total antioxidant/oxidant capacity values will be examined.

      The sample calculation was made using the Vanderbilt University Sample Calculation Tool,
      benefiting from the antioxidant capacity researches previously done in individuals with
      osteoarthritis in the literature. Assuming a standard deviation of ±20 in the study, the
      minimum sample size to be taken with 80% power and 5% error was determined as at least 47
      people (case group) and 30 people (control group). In terms of the correct interpretation of
      the research results, the individuals in the case and control groups were similar in terms of
      age, gender and BMI in the selection of the sample (p≥0.05).

      In the study, descriptive statistics (mean, lower value, upper value, standard deviation,
      standard deviation, mean) for data such as anthropometric measurements, daily consumption of
      food groups, energy and nutrient intakes, food consumption amounts and the rate of meeting
      the needs of energy and nutrients (%), number of meals. median) was calculated. The
      conformity of the variables to the normal distribution was examined using the Shapiro-Wilk
      test. Student's t test was used for the comparison of normally distributed variables in the
      groups (osteoarthritis diagnosis-control group), and the Mann-Whitney-U test was used for the
      comparison of non-normally distributed variables. In the comparison of more than two
      measurements, the Friedman test was used in cases where the normal distribution was not
      suitable. Correlations between numerical data were evaluated with the Pearson correlation
      test. The analyzes of the study were made in the SPSS 22.0 statistical package program and
      the statistical significance level was accepted as p<0.05.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Outpatient clinic patients
      
Keywords: Osteoarthritis; Knee Osteoarthritis; Antioxidant Capacity; Oxidant Capacity; Nutrition