bioihbjkbjnl/mcl2 huggingface dataset:
Different Learning Methods of Motor Control Exercises
Condition: Back Pain Without Radiation
MeSH terms: Back Pain
Study type: Interventional

Summary: 
      This study evaluates the effects of self-learning exercise from multimedia content on pain
      and disability in patients with low back pain.
    

Detailed description: 
      For see the full effect of exercise treatment, exercise adherence should be high. In patients
      with chronic non-specific low back pain, the complex nature of the core-stabilization
      exercises decrease the exercise adherence. Some novel studies show that multimedia learning
      can increase efficiancy of complex skill learning and can be better from classic face to face
      learning.

      So this study evaluates the effects of self-learning exercise from multimedia content on pain
      and disability in patients with low back pain.
    

Intervention name(s): Multimedia Learning of Exercises; Face-to-face Learning of Exercises; Manual Therapy; Home Exercise Program
Intervention type(s): Other; Other; Other; Other
Intervention description(s): Patients learn exercise from multimedia content.; Physiotherapist teach exercises to patients; Myofascial Release Techniques and Joint Mobilizations to the Lumbal Area; Patients do at least 20 minutes motor control exercise in a day at home.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Back Pain without Radiation; Low Back Pain, Mechanical
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK1362885 in Type 2 Diabetics
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is the second administration of GSK1362885 in humans. GSK1362885 is a novel,
      potent inhibitor of human glycogen phosphorylase (GP) under development for the treatment of
      type 2 diabetes mellitus (T2DM). This study will investigate the compound's safety,
      tolerability, pharmacokinetics, and pharmacodynamics in subjects with Type 2 Diabetes
      Mellitus.
    

Detailed description: 
      This is the first administration of single doses of GSK1362885 to the target population with
      T2DM. Based on the mechanism of action which involves reducing hepatic glucose output, it is
      possible that day time (AM) or night time (PM) dosing of GSK1362885 could produce different
      plasma glucose lowering effects, acting either on prandial or post-absorptive elevations of
      HGO. This study is designed to compare glucose profiles following AM and PM doses to
      determine if there is any advantage to either one. This study will compare glucose profiles
      following a single dose of GSK1362885 in the morning before breakfast (AM) to a single dose
      administered at night (PM). These two dosing periods will be randomized and each subject will
      receive both dosing regimens. A third dosing period (BID) is not randomized, but is included
      to explore the effects of GSK1362885 on glucose profiles when administered twice daily in a
      24 hour timeframe.
    

Intervention name(s): GSK1362885; GSK1362885
Intervention type(s): Drug; Drug
Intervention description(s): 100mg in the AM, 100mg in the PM, 50mg BID; 100mg in the PM, 100mg in the AM, 50mg BID
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: GSK1362885; Pharmacodynamics; Safety; Pharmacokinetics; T2DM; Tolerability
Follow-up Study of the Effectiveness of Virtual Reality Therapy in Patients With Stroke
Condition: Stroke
MeSH terms: Stroke
Study type: Interventional

Summary: 
      High intensity motion improves motor functions and quality of life in a neurologist. The
      investigators want to improve the clinical condition and quality of life of post-STROKE
      participants with a special sensory motor and visual motor agility therapy. High intensity
      motion improves engine function and quality of life in a neurologist. With special sensory
      motor and visual motility, investigaters want to improve the clinical condition and quality
      of life of STROKE participants. The investigaters randomly select participants who only
      perform the rehabilitation treatment have performed. The other group that will receive the
      study's control group will receive the traditional rehabilitation physiotherapy treatment.
      The investigaters assess the condition and quality of life of the patients. (EQ5-D, Barthel
      index, MRS test) The ivestigaters examine the functional movement and equilibrium variables
      of patients. (6MWT, Berg balance test, postgraduation) After that, participants are
      undergoing a 4-week intensive rehabilitation treatment. All participants are in post stroke.
      Primary Hypothesis will be changes in life-quality tests (EQ5-D, Barthel index, MRS test).
      Functional tests show progress 6MWT, Berg balance test and postural control testing with
      posturography. The results are compared and evaluated among the groups. The expected
      hypothesis is that visual and acoustic stimulation produces a better physical state at higher
      intensity. Patients were followed for 2 years and participated in a follow-up study every six
      months.
    


Intervention name(s): Neurorehabilitation; Neurorehabilitation; Physiotherapy
Intervention type(s): Other; Other; Other
Intervention description(s): Neurorehabilitation - 2 years-long intervention, targeted postural instability and mobility using at-limit intensity sensori and visuomotor agility training. (2/ week); Neurorehabilitation - 2 years-long intervention, targeted postural instability and mobility using at-limit intensity sensori and visuomotor agility training. (3/ week); Physiotherapy 2-years-long (3/week)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: balance; movement; exergaming; posture; quality of life; gait
Home Test of New Sound Processor
Condition: Hearing Loss
MeSH terms: Hearing Loss; Deafness
Study type: Interventional

Summary: 
      The purpose of this clinical investigation is to test a new Sound Processor (SP) to compare
      hearing performance of the new Sound Processor with unaided hearing and Baha 5 SP in adult
      subjects and to investigate which device (new Sound Processor versus Baha 5) the subjects
      prefer.
    


Intervention name(s): New Sound Processor
Intervention type(s): Device
Intervention description(s): The new Sound Processor is intended to be used as part of the Cochlear Baha System which uses bone conduction to transmit sounds to the cochlea. The New Sound Processor is indicated for patients with up to 55 dB sensorineural hearing loss.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Conductive Hearing Loss; Mixed Hearing Loss
AZD9833 China PK Study
Condition: ER+, HER2-, Metastatic Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      A Phase 1 Dose Escalation and Expansion Study of AZD9833 Alone or in Combination in Chinese
      patients with ER Positive, HER2 Negative, Metastatic Breast Cancer
    

Detailed description: 
      This study is designed to investigate and characterize the safety, tolerability and PK of
      AZD9833 monotherapy (Part A, Part B-cohort 1) or in combination with palbociclib (optional
      Part B cohort 2) or everolimus (optional Part B cohort 3) and to explore the preliminary
      anti-tumour activity in Chinese patients
    

Intervention name(s): AZD9833; AZD9833; AZD9833 with palbociclib; AZD9833 with everolimus
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Part A: AZD9833 monotherapy dose escalation.; Part B: AZD9833 monotherapy dose expansion; Part B: AZD9833 with palbociclib dose expansion; Part B: AZD9833 with everolimus dose expansion
Intervention MeSH terms: Everolimus; Palbociclib
Allocation: Non-Randomized
Intervention model: Sequential Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Breast Cancer; Open-label; Phase 1; Safety; Tolerability; Pharmacokinetics; ER Positive; HER2 Negative; Metastatic Breast Cancer
Evaluation of Myocardial Viability by Means of Low-dose Dobutamine Gated SPECT (the DOGS Study)
Condition: Coronary Arteriosclerosis; Heart Failure, Congestive; Myocardial Infarction; Myocardial Ischemia; Myocardial Stunning
MeSH terms: Heart Failure; Myocardial Infarction; Myocardial Ischemia; Coronary Artery Disease; Arteriosclerosis; Myocardial Stunning; Infarction; Ischemia
Study type: Observational

Summary: 
      Viability assessment remains a clinical challenge in patient with coronary artery disease and
      left ventricular dysfunction. Several imaging modalities are available for evaluating
      myocardial viability, based either on perfusion or on contractile reserve analysis. Briefly,
      perfusion analysis is highly sensitive and contractile reserve highly specific. A combined
      analysis of both perfusion and contractile reserve has been proposed to improve the
      diagnostic accuracy in patient referred for a revascularization procedure. However, the value
      of this combined analysis has not been validated in unselected patients referred for
      viability assessment.

      The patients enrolled in the study will undergo a nitrate enhanced rest gated SPECT using a
      Tc-99m labeled tracer (sestamibi or tetrofosmine) followed by a second gated SPECT acquired
      during a low-dose dobutamine infusion (10 mcg/kg/mn). All patients will have a 6-month
      clinical and imaging follow-up, including physical examination and a nitrate enhanced rest
      gated SPECT using the same radiopharmaceutical. All treatments received during this 6-month
      period will be recorded, including medical therapy and coronary revascularization
      (angioplasty, stenting and CABG).

      Finally, the value of baseline perfusion and contractile reserve analysis in predicting left
      ventricular ejection fraction changes at 6-month follow-up will be evaluated.
    


Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The study population consists with patients with documented coronary artery disease and
        left ventricular dysfunction (LVEF < 50%)referred to aNuclear Medicine department for
        myocardial viability assessment
      
Keywords: Coronary Arteriosclerosis; Heart Failure, Congestive; Myocardial Infarction; Myocardial Revascularization; Tomography, Emission-Computed, Single-Photon; Dobutamine; Myocardial Stunning; Myocardial Hibernation
Protein in Feeding Strategies to Accelerate Muscle Recovery From ACL Reconstruction
Condition: Rehabilitative Nutrition for Muscle Recovery From ACL Reconstruction
Study type: Interventional

Summary: 
      Musculoskeletal injury, particularly injuries requiring surgical repair, induce significant
      muscle atrophy, resulting in diminished physical function. The protein turnover-associated
      (diminished protein synthesis, elevated protein breakdown, negative net muscle protein
      balance) etiology of injury and surgical-induced atrophy are, in part, similar to those
      observed with muscle wasting induced by hyper-catabolic and inflammatory conditions and
      prolonged periods of skeletal muscle disuse (e.g., cachexia and joint immobilization).
      Combining dietary strategies to optimize the anabolic properties of beef as a high quality
      protein source that provides essential amino acids prior to surgery and throughout
      post-surgery rehabilitation may attenuate muscle atrophy and accelerate the restoration of
      muscle function. This project will examine the efficacy of habitual consumption of a
      beef-based higher protein meal pattern and post-physical rehabilitation beef protein
      supplementation throughout post-surgical rehabilitation intervention on skeletal muscle
      function in response to anterior cruciate ligament (ACL) repair in healthy, physically active
      adults.

      Stable isotope methodologies, proteomic analysis of muscle protein synthesis, and molecular
      assessments of skeletal muscle atrophy and remodeling will be assessed to evaluate the
      effects of increased protein intake, including consumption of a high quality beef-based
      protein supplement following patient physical therapy sessions on:

        1. Skeletal muscle protein fractional synthetic rates during and in recovery from surgery;

        2. Inflammatory, proteolytic, and anabolic intramuscular signaling during surgery and their
           association with skeletal muscle protein synthesis and muscle function;

        3. Muscle size and functional recovery;

        4. Duration to return to routine exercise, sport, or physical activity.
    


Intervention name(s): Diet Intervention_AP-CPT; Diet Intervention_PP-PPT
Intervention type(s): Other; Other
Intervention description(s): Adequate Protein_Carbohydrate Post Therapy (AP-CPT) where protein intake will be 1 g/kg/d for the duration of the study .; Optimal Protein_Protein Post Therapy (OP-PPT) with protein intake set at 2.0 g/kg/day for the duration of the study
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: rehabilitative nutrition; protein; beef; ACL reconstruction; protein synthesis; proteolysis; muscle mass; muscle strength
Expanding Comparative Effectiveness Research (CER) Capability Through Complex Patient Relationship Management
Condition: Diabetes; Hyperlipidemia
MeSH terms: Hyperlipidemias
Study type: Interventional

Summary: 
      The investigators are testing whether patients with diabetes can communicate with our health
      care system through text messaging. The investigators will look at how often they respond to
      prompts for blood pressures, blood sugars, and step counts. The investigators will also see
      if they come in for lab tests when prompted by text message. Also, for patients overdue for
      medication refills, the investigators will ask them why they have not yet called for the
      refill.
    

Detailed description: 
      Patients will be sent text messages through a software interface, the Patient Relationship
      Manager (PRM). A registered nurse will also use PRM to receive incoming responses. Tasks will
      be created for her to outreach to patients who have out of range text responses or poor
      response rates. This intervention if a feasibility study to see if patients can communicate
      with the investigator's health care system and potentially utilize PRM to better manage their
      diabetes.
    

Intervention name(s): Text Message prompts
Intervention type(s): Other
Intervention description(s): In this single armed intervention, patients will receive text message prompts
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Text; SMS; diabetes; self-monitoring; self-management; adherence
Clinical Performance of a New Daily Disposable Contact Lens Worn in a Neophyte Population.
Condition: Refractive Error; Myopia
MeSH terms: Refractive Errors
Study type: Interventional

Summary: 
      This study seeks to evaluate the impact of wearing a new daily disposable soft contact lens
      on the neophyte population.
    


Intervention name(s): spectacles; narafilcon A soft contact lenses
Intervention type(s): Device; Device
Intervention description(s): habitual spectacles; narafilcon A daily disposable contact lenses
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Female Subjects.
Condition: Anesthesia; Sedation
Study type: Interventional
Phase: Phase 1

Summary: 
      This study was a single-center positive-controlled, randomized, dose-escalation study of
      HSK3486 in healthy female subjects administered as a single IV bolus dose.Subjects were
      confined to the study unit from the evening of Day -1 until the morning of Day 2, then were
      required to return for a follow up visit on Day 5. Intensive safety, PD and PK assessments
      were performed prior to dosing on Day 1 until 24 hours post-dose (Day 2).
    


Intervention name(s): HSK3486; Propofol
Intervention type(s): Drug; Drug
Intervention description(s): HSK3486 was administered as a single dose over a 1 minute infusion period. There were five cohorts of six subjects per cohort (5 HSK3486:1 propofol).; Propofol, at a dose of 2.5 mg/kg, was administered as a 1 minute infusion at a constant rate via infusion pump.
Intervention MeSH terms: Propofol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Yoga for Anxiety in Adults
Condition: Parkinson Disease; Anxiety
MeSH terms: Parkinson Disease; Anxiety Disorders
Study type: Interventional

Summary: 
      The purpose of this study is to investigate the effect of a telerehabilitation-yoga
      intervention delivered remotely via videoconferencing on adults with Parkinson's Disease and
      anxiety symptoms.
    

Detailed description: 
      A single group intervention study of adults (18-80 years-old) with Parkinson's Disease and
      anxiety symptoms undergoing a 6-week intervention of 30-minute yoga classes delivered
      remotely through videoconferencing 2-3 times per week. Subjects with symptoms of anxiety as
      indicated by their score on the Parkinson's Anxiety Scale will complete yoga classes
      delivered at-home with videoconferencing, receiving one-on-one yoga instruction including
      breathing, postures, and meditation/relaxation for two-three times a week. Data collection
      will occur remotely via videoconferencing at 0-weeks, 6-weeks after a waiting period,
      12-weeks after the intervention, and 6-weeks after the last lab visit. Data collection will
      include demographics, mental health questionnaires, motor assessments, enjoyment, usability,
      and follow-up yoga status. Each yoga session will be video recorded to aide in recording
      adherence, adverse events, and challenges.
    

Intervention name(s): Tele-yoga
Intervention type(s): Other
Intervention description(s): Subjects will undergo 30-minute yoga sessions delivered remotely 2-3 times/week for 6-weeks. The yoga sessions will be delivered one-on-one and will include 5-7 minutes of breathing exercises 15-20 minutes of postures, and 5-7 minutes of relaxation and meditation exercises.
Intervention model: Single Group Assignment
Intervention model description: This is a single group intervention study of adults (18-80 years-old) with Parkinson's Disease and anxiety symptoms undergoing a 6-week intervention of 30-minute yoga classes delivered remotely through videoconferencing 2-3 times per week. There will be baseline testing, a 6-week waiting period, timepoint-two testing, a 6-week intervention, post-intervention testing, and 6-week follow-up testing.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Yoga, anxiety, Parkinson's Disease, telerehabilitation
The Characterization of Blood Volumes of Commercially Available Lancing Devices
Condition: Diabetes
Study type: Observational

Summary: 
      Characterize expressed blood volume ≥1μL across representative, commercially available
      lancing device systems using finger sticks.
    

Detailed description: 
      Primary Objective:

      • Characterize expressed blood volume ≥1μL across representative, commercially available
      lancing device systems using finger sticks.

      Secondary Objectives: the following characterizations will be performed in the data analysis
      within each device and across each device:

        -  Correlation of Subject pain response to blood volume collected;

        -  Proportion of Subjects that produce sufficient blood to fill a 1µl test strip;

        -  Proportion of Subjects that generate ≥1µl blood volume;

        -  Proportion of Subjects who generate multiple- times the blood volume needed to fill a
           1µl test strip

        -  Proportion of Subjects who generate multiple- times ≥1µl of blood volume

        -  Proportion of Subjects that produce on average (≥1µl) of blood volume on 1st attempt

        -  Proportion of Subjects that produce on average (≥1µl) of blood volume on their first and
           second lancing attempt
    

Intervention name(s): Delica Lancing Device; Flash Lancing Device; Easy Touch Lancing Device; Glucoject Lancing Device; Microlet Lancing Device; Multiclix Lancing Device; Fastclix Lancing Device; Reli-On Lancing Device
Intervention type(s): Device; Device; Device; Device; Device; Device; Device; Device
Intervention description(s): Characterize Blood Volume and Pain under normal use circumstances; Characterize Blood Volume and Pain under normal use circumstances; Characterize Blood Volume and Pain under normal use circumstances; Characterize Blood Volume and Pain under normal use circumstances; Characterize Blood Volume and Pain under normal use circumstances; Characterize Blood Volume and Pain under normal use circumstances; Characterize Blood Volume and Pain under normal use circumstances; Characterize Blood Volume and Pain under normal use circumstances
Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        People with diabetes
Evaluate Safety of Tramadol in the Management of Postoperative Pain Following Surgery
Condition: Pain Management
Study type: Interventional
Phase: Phase 3

Summary: 
      The study evaluates the safety of IV tramadol managing post-operative pain following surgery.
    

Detailed description: 
      (Non-clinical summary) Tramadol is a centrally-acting synthetic analgesic of the
      aminocyclohexanol group with opioidlike effects. Tramadol is extensively metabolized
      following administration, which results in a number of enantiomeric metabolites that display
      different opioid-receptor binding properties, and monoaminergic reuptake inhibition.
    

Intervention name(s): Tramadol
Intervention type(s): Drug
Intervention description(s): IV; 50 mg given at Hours 0, 2, 4, 8 and every 4 hours thereafter, for a total of up to 43 doses
Intervention MeSH terms: Tramadol
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
A Study of NeoRecormon in Patients With Chronic Kidney Disease.
Condition: Anemia
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic
Study type: Interventional
Phase: Phase 4

Summary: 
      This 2 arm study will compare the level of anemia, and the decline in renal function, between
      patients receiving NeoRecormon, and those not receiving it. Patients with chronic kidney
      disease, stage 2-4, and not receiving dialysis, will be randomized 2:1 to a group receiving
      NeoRecormon (at a dose determined by the investigator to achieve and maintain an Hb level of
      120-135 g/L), or to a control group not receiving NeoRecormon. The anticipated time on study
      treatment is 3-12 months, and the target sample size is <100 individuals.
    


Intervention name(s): epoetin beta [NeoRecormon]
Intervention type(s): Drug
Intervention description(s): At a dose to achieve and maintain an Hb level of 120-135g/dL.
Intervention MeSH terms: Epoetin Alfa
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment