The Effect of Vagus Nerve Stimulation on Cycling Ergometry and Recovery
Condition: Healthy; Sports Physical Therapy; Activity, Motor
Study type: Interventional

Summary: 
      It is aIt is aimed to examine the possible benefits and effects of the use of Transcutaneous
      Auricular Vagus Nerve Stimulation to be applied in healthy individuals for sportive purposes
      on recovery and sportive performance level.
    

Detailed description: 
      The 90 people between the ages of 18-35 will be included in the study. Each participant will
      be randomly divided into 3 groups to be homogeneous after the necessary calculations are made
      by evaluating with age, gender, weight, height and body mass index before starting the study.

      The groups are; It will be in the form of Unilateral Stimulation (n=30), Bilateral
      Stimulation (n=30) and Bilateral Sham Stimulation (n=30) groups.

      After the initial assessment, participants in all groups will be asked to do 30 minutes of
      cycling exercise at maximum performance under the same wattage load. Cycling will be
      re-evaluated after exercise. After the assessment is complete, stimulation will be given with
      Vagustim for 20 minutes non-invasively. After vagus nerve stimulation, a re-evaluation will
      be made and the protocol for that day will be terminated.

      After the pain and fatigue rating scale, the evaluation will be completed by determining the
      lactate level in the blood with the Lactat Scout. Vagus nerve stimulation will be applied
      with the Vagustim device for 20 minutes, keeping it biphasic, with a frequency of 10 Hz, a
      pulse width of 300 μs in Modulation mode, and a constant current where the participant feels
      the current comfortably.

      At the end of the Cycling Ergometer Test and Vagus nerve stimulation, the Autonomic Nervous
      System, pulse and blood pressure will be evaluated with Polar H10 within 5 minutes.
    

Intervention name(s): Unilateral Stimulation; Bilateral Stimulation; Bilateral Sham Stimulation; Bicycle Ergometer Test; Lactat Scout; Polar H10; Vagustim Device
Intervention type(s): Device; Device; Device; Diagnostic Test; Diagnostic Test; Diagnostic Test; Device
Intervention description(s): With the Vagustim device, vagus nerve stimulation will be applied in one ear for 20 minutes, with a frequency of 10 Hz, a pulse width of 300 μs in Modulation mode, and a constant current that the participant will feel the current comfortably.; With the Vagustim device, vagus nerve stimulation will be applied in one ear for 20 minutes, with a frequency of 10 Hz, a pulse width of 300 μs in Modulation mode, and a constant current that the participant will feel the current comfortably.; Participants were shown that the device was working, but no current was given.; Participants in this group were asked to perform bicycle exercise with maximum performance under 30 watts for 30 minutes.; For lactic acid analysis measurement, the middle fingertip of the athlete is disinfected with an alcohol swab and a blood sample is taken by puncturing the finger.The measuring range is 0.5 - 0.25 mmol/L.; RR times transferred to computer with Polar H10 are used in heart rate variability analysis. Heart rate data will be transferred to the Kubios program and heart rate variability parameters will be calculated and data on the autonomic nervous system (RMSSD, PNS index, Stress index, SNS index, pNN50, Power LF, Power HF and LF/HF ratio) will be obtained.; Vagustim Health Technologies Vagus stimulator device is used for this experiment.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 90 healthy young individuals were included in the study. Participants were randomly divided into 3 groups as unilateral (n=30, 15 female, 15 male), bilateral (n=30, 15 female, 15 male) and bilateral sham (n=30, 15 female, 15 male) groups. ). The cycling exercise was performed at maximum performance for 30 minutes under the same wattage load. Non-invasive ear stimulation was performed with the Vagustim device according to the participant groups. Pulse, systolic and diastolic blood pressure, distance, pain, fatigue, lactic acid level and autonomic nervous system were evaluated before, after and at the end of cycling exercise. Oneway Anova test and Kruskal Wallis test were used between groups. Dunn's test was used to determine the group that caused the difference. Analysis of variance was used for repeated measurements, Bonferroni test and Friedman test were used for in-group comparisons. Significance was evaluated at the p<0.05 level.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Vagus Nerve Stimulation; Physiological Parameters; Recovery; Cycle Ergometer Test; Transcutaneous Auricular