bioihbjkbjnl/mcl2 huggingface dataset:
The Effect of an α2-Adrenoceptor Antagonist (Yohimbine) on Dynamic Autoregulation in the Human Middle Cerebral Artery and Ophthalmic Artery
Condition: Blood Flow Velocity; Autoregulation; Ocular Physiology
Study type: Interventional
Phase: Phase 4

Summary: 
      Blood flow autoregulation is defined as the ability of a tissue to maintain a relatively
      constant flow, despite moderate alterations in perfusion pressure. Similar to the cerebral,
      renal, coronary and skeletal muscle circulations, the ocular vascular bed shows the property
      of flow autoregulation. This homeostatic mechanism allows blood supply to the eye to match
      metabolic demand during daily activities, such as changes in posture, or in more critical
      conditions.

      Autoregulation has been found to be a complex phenomenon, showing heterogeneity in its site
      and time course of action. Since metabolic, myogenic, neurogenic and possibly
      endothelium-related mechanisms may be involved, several factors may vary depending on the
      challenging stimulus, the vessel tone, or the degree of impairment of autoregulation.

      To study the dynamics of ocular autoregulation, it is necessary to introduce a step
      disturbance (stimulus) in ocular perfusion pressure and to record the responses of ocular
      blood flow continuously before and after this step disturbance. The investigators have
      employed a mechanical noninvasive technique to induce an ocular perfusion pressure step
      disturbance without drugs or changes in the concentration of vasoactive substances in the
      blood by using the thigh cuff technique inducing a small step decrease in ocular perfusion
      pressure.

      With this technique the investigators could show significant differences in the time response
      of blood velocities in the ophthalmic and middle cerebral artery. This clearly indicates
      different mechanisms to be responsible for autoregulatory mechanisms distal to the vessels.

      Interestingly our results indicate that in the ophthalmic artery a late vasoconstriction
      occurs. Many previous investigations have demonstrated that sympathetic nerve stimulation
      causes vasoconstriction in the ocular circulation. Accordingly, the present study tests the
      hypothesis that α2-adrenoceptors are involved in the dynamic regulation of blood flow in the
      ophthalmic and middle cerebral artery after a step decrease in perfusion pressure.
    


Intervention name(s): Yohimbine hydrochloride
Intervention type(s): Drug
Intervention MeSH terms: Yohimbine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double
Primary purpose: Treatment
Keywords: ultrasonography
Clinical Trial of Autologous Adipose Tissue-Derived Mesenchymal Progenitor Cells (MPCs) Therapy for Knee Osteoarthritis
Condition: Knee Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional
Phase: Phase 2

Summary: 
      Current medication treatments for KOA aim to relieve inflammation and pain, but they do
      little to delay or reverse the disease progression and most medications have obvious side
      effects. When the conservative treatments are useless to patients and joint deformities and
      joint disfunction, the patients may require surgery. Although surgery of the joints can
      relieve the pain temporarily, long-term effect (over 10 years) is hard to achieve.
    

Detailed description: 
      Human adipose-derived mesenchymal progenitor cells (haMPCs) are obtained through a series of
      procedures: firstly, the fresh adipose tissue is digested with collagenase, filtered,
      centrifuged and then discard mature adipose cells to obtain adipose tissue-derived nuclear
      cells also called stromal vascular fraction cells (SVFs). In the end, haMPCs are prepared
      after being purified andamplified to P2-P5. When induced by specific factors, haMPCs have a
      potential for multilineage differentiation towards bone, cartilage and fat tissue both in
      vivo and in vitro. The haMPCs can secrete a number of soluble mediators to stimulate the
      proliferation of endogenous progenitor cells, to act as nutrients, to be immunosuppressive,
      to be anti-inflammatory, to prevent fibrosis and promote angiogenesis. The cytokines secreted
      by haMPCs play a synergic role in restoring the dynamic balance of synthesis and decompositon
      of cartilage tissue, and finally to repair the impaired cartilage.
    

Intervention name(s): Mesenchymal progenitor cells; Sodium Hyaluronate
Intervention type(s): Biological; Biological
Intervention description(s): Administrated for intra-articular injection
Intervention MeSH terms: Hyaluronic Acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
The Effectiveness of Pharmacopuncture on Acute Tension Headache
Condition: Tension Headache
MeSH terms: Tension-Type Headache; Headache
Study type: Interventional

Summary: 
      This study is a double blind, randomized controlled trail. condition/disease: acute tension
      headache treatment/intervention: Pharmacopuncture
    

Detailed description: 
      "Pharmacopuncture is a treatment that combines 2 of the most frequented Korean medicine
      treatment methods - traditional acupuncture and herbal medicine - by injecting herbal
      medicine extract at acupoints.

      This treatment is known to be an important part of Korean medicine treatment. However, there
      has been no specific value for the effect of this treatment.

      Therefore, the investigators are going to conduct a randomized controlled trials to verify
      the efficacy and safety of Pharmacopuncture. From September 2022 to December 2023, the
      investigators are going to collect 80 inpatients who are suffering from Tension headache with
      the numeric rating scale(NRS) over 5 after injury by acute traffic accident(TA). For
      experimental group(n=40), the investigators will conduct Pharamacopuncture on suboccpital
      muscle three times(on 2nd, 3rd and 4th day of hospitalization) and other Korean medical
      treatment. For control group(n=40), just Korean medical treatment except Pharamacopuncture on
      suboccpital muscles will be conducted.

      For these two groups, the investigators will compare Numeric Rating Scale(NRS) of headache,
      NRS of Neck pain, Headache Disability Index(HDI), Headache Impact Test-6(HIT-6), EuroQol
      5-Dimension (EQ-5D-5L) and Patient Global Impression of Change (PGIC)."
    

Intervention name(s): Pharmacopuncture; Korean medical treatment
Intervention type(s): Procedure; Procedure
Intervention description(s): Pharmacopuncture is a treatment that combines 2 of the most frequented Korean medicine treatment methods - traditional acupuncture and herbal medicine - by injecting herbal medicine extract at acupoints.; acupuncture treatment, chuna, pharmacoacupuncture, Korean herbal medicine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Radiation Biodosimetry in Patients Treated With Total Body Irradiation (TBI)
Condition: Cancer
Study type: Observational

Summary: 
      The purpose of this study is to develop blood tests and urine tests that can tell doctors how
      much radiation a person has been exposed to. Doctors know how much radiation patients are
      exposed to in certain medical situations. An example of this would be radiation treatment for
      cancer. Radiation treatment machines are programmed to give exact doses of radiation.
    

Detailed description: 
      MSKCC patients undergoing TBI as part of a hematopoietic stem cell transplant (HSCT) will
      have blood drawn and urine collected for use in the validation and refinement of new methods
      for rapid high-throughput radiation biodosimetry. These blood and urine samples will be
      collected before, and at defined times after TBI. Blood sampling will occur in the same
      manner that it does during routine patient care during HSCT.
    

Intervention name(s): Blood Samples
Intervention type(s): Other
Intervention description(s): blood (approximately two 4 ml; equivalent to less than 2 tablespoon) and urine (a cup of urine) samples or testing a total of three times. Blood will be drawn and urine will be collected once before radiation treatment and twice after first radiation treatment.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Potential research subjects will be identified by the primary Radiation Oncologist whom the
        patient is referred to by the Adult or Pediatric Bone Marrow Transplant Service.
      
Biospecimen description: 
      Blood and Urine
    
Keywords: total body irradiation; Cancer; Hematopoietic System
Effects of Losartan on Hepatic Fibrogenesis in Chronic Hepatitis C
Condition: Chronic Hepatitis C; Liver Fibrosis
MeSH terms: Hepatitis A; Hepatitis C; Hepatitis C, Chronic; Hepatitis; Hepatitis, Chronic; Liver Cirrhosis; Fibrosis
Study type: Interventional
Phase: Phase 4

Summary: 
      There is evidence on the beneficial effects of the administration of angiotensin II type 1
      (AT1) receptors antagonists on liver fibrosis in hepatic stellate cells, experimental models
      of liver fibrosis in rodents and limited information in chronic hepatitis C with mild
      fibrosis.

      The purpose of this study is to investigate the effect of long-term administration of oral
      Losartan, an AT1 receptor antagonist, on liver fibrogenesis in patients with chronic
      hepatitis C and fibrosis F2-F3 (METAVIR score).
    


Intervention name(s): Losartan
Intervention type(s): Drug
Intervention MeSH terms: Losartan
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Hepatitis C, Chronic
Acupuncture for Patients With Function Dyspepsia
Condition: Functional Dyspepsia; Postprandial Distress Syndrome
MeSH terms: Dyspepsia
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      Hypothesis: Acupuncture is efficacious and safe for patients with functional dyspepsia

      Design:

        -  A single blind randomized controlled trial

        -  200 participants will be included

        -  Two arms: acupuncture and sham acupuncture group
    

Detailed description: 
      Aim: to clarify the efficacy and safety of acupuncture for patients with functional dyspepsia
      Design: A single blind randomized controlled trial will be performed in Chengdu, Hunan and
      Chongqing province. Two hundred participants will be randomly assign to acupuncture and sham
      acupuncture group. Each participants will receive 20 sessions of acupuncture in 4 weeks, with
      a duration of 30 minutes in a session. The primary outcome is Patients' global assessments of
      efficacy in 16 weeks after inclusion. Secondary outcomes include validated Leeds Dyspepsia
      Questionnaire, Nepean dyspepsia index, etc.
    

Intervention name(s): acupuncture; sham acupuncture
Intervention type(s): Other; Other
Intervention description(s): In this group, acupuncture is given according to traditional acupuncture theories.; Sham acupuncture points will be used in this trial, with needle penetration.
Other intervention name(s): use hwato acupuncture needles; verum acupuncture
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Functional dyspepsia; postprandial distress syndrome
A Study of Intravenously (IV) Infused or Subcutaneously (SC) Injected Risankizumab in Healthy Adult Participants in China
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      The objective of this study to assess the pharmacokinetics, safety, tolerability and
      immunogenicity following a single subcutaneous (SC) or intravenous (IV) dose of risankizumab
      in healthy Chinese participants.
    


Intervention name(s): Risankizumab; Risankizumab
Intervention type(s): Drug; Drug
Intervention description(s): Intravenous (IV) Infusion; Subcutaneous (SC) Injection
Other intervention name(s): ABBV-066; SKYRIZI; ABBV-066; SKYRIZI
Intervention MeSH terms: Antibodies, Monoclonal
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Healthy Volunteers; Risankizumab; ABBV-066; SKYRIZI
Comparison of the Effects of Standardized Chokeberry Extracts With Various Formulations on the Levels of Selected Markers Associated With Cardiovascular Disease
Condition: Hypertension; Hypercholesterolemia
MeSH terms: Hypertension; Cardiovascular Diseases; Hypercholesterolemia
Study type: Interventional

Summary: 
      The aim of the study is to compare in a clinical condition the effect of standardized
      chokeberry extract in different formulations and a complex preparation containing chokeberry
      extract and other active ingredients in on the levels of selected markers associated with
      cardiovascular diseases in people with a predisposition to the development of these diseases.
    

Detailed description: 
      Randomized, double-blind, parallel study conducted under medical supervision on a group of 40
      patients with known hypertension and/or hypercholesterolemia. Patients receive one of the
      investigational products or placebo for 6 weeks. Before and after the study, the following
      parameters are analyzed: extended lipid panel (total cholesterol (TC), triglycerides (TG),
      low-density lipoprotein (LDL), HDL and lipoprotein A, apolipoprotein Apo A1 and Apo B),
      levels of glucose, insulin, homocysteine, markers of kidney and liver function (alanine
      aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), blood
      urea nitrogen (BUN), uric acid). Effects on blood pressure and anthropometric parameters are
      also being evaluated.
    

Intervention name(s): Complex product; Chokeberry extract in liposomal formulation; Chokeberry extract in traditional formulation; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Other
Intervention description(s): 400 mg of chokeberry extract in liposomal formulation and L-arginine, vitamin E, vitamin A, folic acid, chromium; 400 mg of chokeberry extract in liposomal formulation; 400 mg of chokeberry extract in traditional formulation; Placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Other
Keywords: Hypertension; Hypercholesterolemia; Aronia extract; Chokeberry extract
The Influence of Breakfast on Hormone Responses and Cognitive Performance
Condition: Insulin Resistance
MeSH terms: Insulin Resistance
Study type: Interventional

Summary: 
      The purpose of this study is to see what effect skipping breakfast versus consuming breakfast
      has on cognitive performance and the hormones responsible for glucose homeostasis in lean and
      obese adolescent males. The subjects will be tested on their ability to maintain attention
      when given several tasks called continuous temporal expectancy tasks (CTET) and
      electrophysiological signals using electroencephalogram (EEG) will be monitored. These two
      study groups will be randomized to one of two orders: (A,B) or (B,A) where A = breakfast
      intervention and B = no breakfast. There will be a washout period of 7 days in between study
      visits.
    

Detailed description: 
      Eating unhealthy foods and not exercising regularly contributes to obesity in children. Other
      unhealthy behaviors, such as skipping meals can also lead to obesity. Breakfast is known to
      be the most important meal of the day, yet many people skip breakfast. Skipping breakfast can
      cause an imbalance in the hormones that control blood glucose.

      Skipping breakfast can affect how well insulin works at lowering blood glucose at later meal
      times. The impact of breakfast on glucose homeostasis is different from that of lunch and
      dinner. This became evident when a group of researchers studied the effect of skipping
      breakfast on hormone responses after subsequent isocaloric lunch and dinner in adults with
      Type 2 diabetes. The study showed that in Type 2 diabetics, skipping breakfast leads to
      increased post-prandial hyperglycemia and decreased glucagon-like peptide-1 (GLP-1) release,
      impairing the insulin response to hyperglycemia. Plasma free fatty acids (FFA) levels were
      found to be significantly higher after lunch and dinner when breakfast was omitted. It has
      been shown that acute elevation of FFA induces hepatic insulin resistance and increased
      hepatic glucose production in patients with Type 2 Diabetes Mellitus and in non-diabetic
      controls. Impaired insulin secretion can predispose to conditions such as obesity, and other
      diseases.

      Skipping breakfast can also have a negative effect on children's ability to keep focus and
      attention. The CTET is a tool that can be used to directly measure attention using an EEG and
      is a highly sensitive measure of neural processing.
    

Intervention name(s): A= Yes Breakfast; B=No Breakfast
Intervention type(s): Other; Other
Intervention description(s): Study visit will include analysis of cognitive function (CTET), insulin, glucagon, C-peptide, free fatty acids, and GLP-1 when given breakfast and lunch; Study visit will include analysis of cognitive function (CTET), insulin, glucagon, C-peptide, free fatty acids, and GLP-1 when breakfast is skipped and lunch is provided.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Bioavailability of Xanthones From Mangosteen
Condition: Healthy Volunteers
Study type: Observational

Summary: 
      Mangosteen is a tropical tree. The peel of mangosteen fruit is used in traditional medicine.
      The purpose of this study was to determine the bioavailability of the xanthones from
      mangosteen juice in adult human subjects.
    

Detailed description: 
      Garcinia mangostana L. (mangosteen) is a tropical tree native to Southeast Asia. The pericarp
      of mangosteen fruit is used in traditional medicine to treat inflammation, infections,
      wounds, and diarrhea. The proposed health-promoting effects have been attributed to a family
      of polyphenols referred to as xanthones. Since its introduction into the United States,
      juices and products containing mangosteen fruit have become a top-selling botanical dietary
      supplement. This commercial success largely has been the result of aggressive marketing of
      health claims based on in vitro observations and anecdotal reports.

      The purpose of this study was to determine the bioavailability of xanthones from mangosteen
      juice in adult human subjects. After an overnight fast of at least 10h, male and female
      subjects were admitted to the Ohio State University Clinical Research Center. Volunteers
      ingested 2 ounces of 100% mangosteen juice as part of a western-style breakfast. Pericarp
      particles accounted for 1% of the mass and 99% of total xanthone content in the juice. This
      dose provided 130 ± 2 mg total xanthones. Blood was collected prior to breakfast and
      1,2,3,4,6,8 and 24h. Subjects were fed a mangosteen-free lunch and released from the unit
      after the 8h collection, refraining from mangosteen containing products until final
      collection of blood at 24h. Urine was collected for the 24 test period.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        5 female and 5 male healthy, non-smoking subjects admitted to the Clinical Research Center
        at The Ohio State University.
      
Biospecimen description: 
      Sera and urine
    
Keywords: mangosteen; xanthones; dietary supplement; botanical supplement; bioavailability; Determine bioavailability of mangosteen xanthones in adults
A Study Of The Effect Of PF-04802540 On Sleep Measures
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine if PF-04802540 decreases REM sleep.
    


Intervention name(s): PF-04802540; PF-04802540; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 5 mg capsule, single dose; 15 mg capsule, single dose; Placebo capsule, single dose
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: PF-04802540, polysomnography, REM, cross over
A Gene Transfer Therapy Study to Evaluate the Safety of Delandistrogene Moxeparvovec (SRP-9001) in Participants With Duchenne Muscular Dystrophy (DMD)
Condition: Duchenne Muscular Dystrophy
MeSH terms: Muscular Dystrophies; Muscular Dystrophy, Duchenne
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This is an open-label single-dose gene transfer therapy study evaluating the safety of
      delandistrogene moxeparvovec intravenous (IV) administration in boys with DMD. This study
      will consist of 2 Cohorts. Cohort A will include participants ages 3 months to 3 years, and
      Cohort B will include participants ages 4 to 7 years old. All participants in the study will
      receive IV delandistrogene moxeparvovec.
    


Intervention name(s): delandistrogene moxeparvovec
Intervention type(s): Genetic
Intervention description(s): Single IV infusion of delandistrogene moxeparvovec.
Other intervention name(s): SRP-9001; delandistrogene moxeparvovec-rokl; ELEVIDYS
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Duchenne; Gene Therapy; DMD; Dystrophin; Pediatric; Gene-Delivery; Gene Transfer Therapy
Oral Contraceptive Pills Compared to Vaginal Rings
Condition: Pregnancy
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether teens and young women would prefer the
      Nuvaring to oral contraceptive pills after having tried both methods.
    

Detailed description: 
      Sexually active young women (n=130), aged 15-21 years, were randomly assigned to use either
      the vaginal ring or oral contraceptive pills for an initial study interval of three 28-day
      cycles, followed by three cycles of the alternate method. Participants completed surveys
      about method use, acceptability and side effects at baseline, after three cycles, and after
      six cycles, as well as in a follow up telephone interview one month after study completion.
    

Intervention name(s): OCPs; vaginal ring
Intervention type(s): Drug; Device
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: vaginal ring; Oral contraceptive pills; Teenagers; Young women; Patient satisfaction