Creatine Monohydrate Versus Creatine Hydrochloride on Strength and Body Composition in Elite Team-Sport Athletes
Condition: Healthy Lifestyle
Study type: Interventional

Summary: 
      A triple-arm double-blinded placebo-controlled repeated-measures randomized clinical trial in
      Colombian elite team-sport athletes. The aim is to evaluate the effects on strength-related
      parameters and body composition after eight weeks of supplementation with creatine
      monohydrate (CrM) and creatine hydrochloride (Cr-HCl). The study will be reported following
      the Consolidated Standards of Reporting Trials (CONSORT) extension to Multi-Arm
      Parallel-Group Randomized Trials. All variables will be measured at baseline and after eight
      weeks.
    

Detailed description: 
      Creatine monohydrate (CrM) is the most studied nutritional supplement and, therefore, one of
      the most popular ergogenic nutritional aids for athletes. Studies have shown that CrM
      supplementation increases intramuscular creatine concentrations which enhances exercise
      performance and improves body composition in different populations (from young athletes to
      older adults).

      It is important to note that the U.S. Food and Drug Administration (FDA) have recognized CrM
      as a safe ingredient (Generally Recognized as Safe, GRAS - No. GRN 000931). In spite of this,
      other forms such as creatine chloride (Cr-HCl) have been marketed as a more bioavailable
      sources of creatine. Since there are not studies that rigorously compare the effects of CrM
      versus Cr-HCl on physical performance and body composition, the aim of this study is to
      evaluate the effects of a 8-week supplementation protocol with the two forms of creatine
      (comparing to placebo) on neuromuscular strength and body composition in Colombian elite
      team-sport athletes.
    

Intervention name(s): Creatine Monohydrate; Placebo; Creatine Hydrochloride
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): The CrM group supplemented the diet with five grams of micronized creatine monohydrate per day for eight weeks. The CrM supplement was fully dissolved in ≈500 mL of water and drank immediately after each training session (in the morning on non-training days).; A placebo group intakes five grams of maltodextrin daily throughout the study. The placebo supplement was fully dissolved in ≈500 mL of water and drank immediately after each training session (in the morning on non-training days).; The Cr-HCl group supplemented the diet with five grams of micronized creatine monohydrate per day for eight weeks. The Cr-HCl supplement was fully dissolved in ≈500 mL of water and drank immediately after each training session (in the morning on non-training days).
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: This was a double-blinded placebo-controlled repeated-measures randomized clinical trial in elite team-sport athletes with three arms in parallel.
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Creatine; Strength; Body Composition; Athletic performance; Nutritional supplementation