The Efficacy of Chlorhexidine Gluconate Pre - Disinfection Scrubbing in Preventing Surgical Site Infections for Hepatectomy Patients
Condition: Liver Tumors
MeSH terms: Infections; Surgical Wound Infection; Liver Neoplasms
Study type: Interventional
Phase: Phase 4

Summary: 
      To test whether pre - disinfection skin scrub with 4% chlorhexidine gluconate is more
      effective on the reduction of surgical site microbial colonization and subsequent infection
      than is normal saline.
    

Detailed description: 
      Surgical site infections (SSIs) following elective surgical procedures occur most commonly as
      a result of colonization by the patient's native skin flora . The most common pathogens
      causing SSIs are Staphylococcus aureus and coagulase-negative Staphylococci , components of
      normal skin flora . Therefore, preoperative disinfection of the surgical site with an
      antiseptic skin preparation is standard practice before any surgical intervention to decrease
      skin microbial counts before incision . It is considered an important step in limiting
      surgical wound contamination and preventing infection.

      A variety of skin-preparation agents and methods are available for preventing surgical site
      infections and the techniques for preoperative cleansing of the skin vary among hospitals and
      surgeons. There is a pressing need to elucidate the effect of cutaneous disinfection with
      chlorhexidine gluconate ( CHG ) in prevention of surgical site infections.

      Many studies demonstrated that comparisons with cutaneous disinfection with povidone-iodine,
      disinfection with CHG before insertion of an intravascular device and for post-infection site
      care can substantially reduce the incidence of device-related infection .

      Hence, this study aimed to test whether an additional chlorhexidine gluconate scrub followed
      by a routine disinfection would lower the incidence of surgical site culture and subsequent
      infection after hepatic resection. This data will show the originality and clinical
      importance of a cutaneous pre-disinfection scrubbing solution for such risk patients with
      hepatectomy.
    

Intervention name(s): Chlorhexidine gluconate; 0.9% Sodium Chloride
Intervention type(s): Drug; Drug
Intervention description(s): (i)a sterile washcloth was saturated with 60ml of chlorhexidine gluconate (4%) cleansing solution and generously applied to the predefined surgical site followed by vigorous scrubbing for 3 min. (ii) after being patted with a sterile towel, the standardized 3-step disinfection was performed (iii) the applied iodine-alcohol disinfectant contained 70 ml of ethyl alcohol and 10 g of povidone-iodine per 100 ml; (i)a sterile washcloth was saturated with 60ml of sodium chloride (0.9%) and generously applied to the predefined surgical site followed by vigorous scrubbing for 3 min. (ii) after being patted with a sterile towel, the standardized 3-step disinfection was performed (iii) the applied iodine-alcohol disinfectant contained 70 ml of ethyl alcohol and 10 g of povidone-iodine per 100 ml
Other intervention name(s): Antigerm; Hibiscrub; normal saline
Intervention MeSH terms: Chlorhexidine; Chlorhexidine gluconate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: pre - disinfection scrubbing solution; surgical site culture; surgical site infection; liver tumors; hepatectomy; chlorhexidine gluconate