bioihbjkbjnl/mcl2 huggingface dataset:
Duloxetine Potentiates the Analgesic Efficacy of Intrathecal Morphine
Condition: Acute Pain
MeSH terms: Acute Pain
Study type: Interventional

Summary: 
      Duloxetine is a serotonin-norepinephrine reuptake inhibitor primarily used for treatment of
      major depression and anxiety. Duloxetine also has been used in the treatment of chronic pain
      conditions, such as osteoarthritis and musculoskeletal pain. There are few studies examining
      its effect for acute pain. The objective of this study is to evaluate the analgesic effect of
      duloxetine combined with intrathecal morphine for patients subjected to major abdominal
      cancer surgery
    


Intervention name(s): Duloxetine 60mg; placebo
Intervention type(s): Drug; Drug
Intervention description(s): Patients will receive duloxetine, 60 mg tablet 2 hour before operation and will be anesthetized by combined spinal-general anesthesia that includes: spinal anesthesia with morphine 0.3 mg delivered in L4-5 inter spinous space.
General anethseia: Induction of anesthesia was done by intravenous fentanyl, 2 µg / kg and propofol 1 - 2 mg / kg. Endotracheal intubation was achieved by cis-atracurium, 0.15 mg / kg. Maintenance of anesthesia was done by isoflurane and cis-atracurium, 0.03 mg / kg on demand. Additional intraoperative analgesia was consisted of administration of intravenous boluses of fentanyl, 50 µg according to the attending anesthesiologist's decision. At the end of surgery, muscle relaxation was reversed using neostigmine 0.05 mg / kg and atropine 0.01 mg / kg.; Patients will receive placebo tablet 2 hour before operation and will be anesthetized by combined spinal-general anesthesia that includes: spinal anesthesia with morphine 0.3 mg delivered in L4-5 inter spinous space.
General anethseia: Induction of anesthesia was done by intravenous fentanyl, 2 µg / kg and propofol 1 - 2 mg / kg. Endotracheal intubation was achieved by cis-atracurium, 0.15 mg / kg. Maintenance of anesthesia was done by isoflurane and cis-atracurium, 0.03 mg / kg on demand. Additional intraoperative analgesia was consisted of administration of intravenous boluses of fentanyl, 50 µg according to the attending anesthesiologist's decision. At the end of surgery, muscle relaxation was reversed using neostigmine 0.05 mg / kg and atropine 0.01 mg / kg.
Intervention MeSH terms: Duloxetine Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Evaluating the Relationship Between Inflammation, Genetics, and Stress in the Development of High Blood Pressure
Condition: Hypertension
MeSH terms: Hypertension; Inflammation
Study type: Observational

Summary: 
      High blood pressure affects nearly one third of all individuals in the United States. If left
      untreated, it can lead to stroke, heart failure, heart attack, kidney failure, or blindness.
      For many people, the exact cause of high blood pressure is unknown, but it is believed that
      both genetic and environmental factors contribute to the development of the condition. The
      purpose of this study is to examine the importance of genetics, inflammation, and stress on
      the development of high blood pressure.
    

Detailed description: 
      High blood pressure is a complex condition that can be caused by many factors, including
      obesity, diet, genetics, or stress. Maintaining a healthy balance of sodium in the body is
      important for adequate blood pressure control. Some individuals experience sustained high
      blood pressure during periods of extended stress, combined with the inability to excrete
      enough sodium through urine to re-establish normal blood pressure levels. This type of
      stress-induced high blood pressure is related to interleukin-6 (IL-6), a protein that
      stimulates inflammation and immune responses. To determine the interaction between stress,
      inflammation, and genetics, this study will examine the role of IL-6 in regulating sodium
      levels and blood pressure in individuals undergoing stress. This information will be useful
      in determining new ways to evaluate risk factors for high blood pressure.

      This study will examine previously collected DNA samples from young adults who participated
      in prior genetic studies. There will be no study visits for participants. IL-6, IL-6R,
      glycoprotein 130 (gp130), and C-reactive protein (CRP) genes will be analyzed in all samples;
      changes in plasma levels of IL-6 and CRP in response to stress will be examined in selected
      samples. The parents of participants will be asked to provide cheek swabs for additional DNA
      analysis.
    

Intervention name(s): Induced Stress; Buccal Swab
Intervention type(s): Behavioral; Procedure
Intervention description(s): Participation in an active coping task by playing a video game against another participant.; One Buccal swab collected from each parent
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        15-19 years old African American and European American school children.
      
Biospecimen description: 
      Blood samples of 500 subjects have been collected and stored in previous funded studies.

      Buccal swabs from 599 biological parents have been collected from the current study.
    
Keywords: Blood Pressure, High; Stress; Inflammation
Study to Collect Samples for MIST Analysis of Zibotentan and Bioavailability of Zibotentan and Dapagliflozin in Heatlhy Participants
Condition: Chronic Kidney Disease
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic
Study type: Interventional
Phase: Phase 1

Summary: 
      The study will have 2 independent parts:

      Part 1 of the study is intended to collect samples for Metabolites in Safety Testing (MIST)
      analysis after administration of multiple doses of zibotentan.

      Part 2 of the study is designed to evaluate the relative bioavailability of zibotentan and
      dapagliflozin after dosing with two different fixed-dose combination (FDC) formulations and
      dosing with separate formulations of zibotentan and dapagliflozin.
    

Detailed description: 
      Part 1 will be an open-label, non-randomised, single treatment period. A single treatment
      period during which participants will be resident at the study centre from 2 days before
      dosing (Day -2) until the morning of Day 6.

      Part 2 will be an open-label, randomised, 3-period, 3-treatment, cross-over single dose
      study. Participants will be randomised to one of 3 treatment sequences and will receive 3
      single-dose study interventions. Participants will be resident at the study centre from 2
      days before dosing (Day -2) until Day 3 of the last treatment sequence.

      Participants who were enrolled in Part 1 may not be enrolled in Part 2.
    

Intervention name(s): Zibotentan (Treatment A); Dapagliflozin (Treatment A); Zibotentan/Dapagliflozin - Formulation 1 (Treatment B); Zibotentan/Dapagliflozin - Formulation 2 (Treatment C)
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Zibotentan capsule will be administered orally as multiple doses in Part 1 and as single dose in Part 2.; Dapagliflozin tablet will be administered orally as single dose in Part 2.; Zibotentan/Dapagliflozin tablet will be administered orally as single dose in Part 2.; Zibotentan/Dapagliflozin tablet will be administered orally as single dose in Part 2.
Intervention MeSH terms: Dapagliflozin
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effects of Neural Glides Versus Proprioceptive Neuromuscular Facilitation in Cervical Radiculopathy
Condition: Cervical Radiculopathy
MeSH terms: Radiculopathy
Study type: Interventional

Summary: 
      this project was a Quasi-Experimental Trial. conducted to compare the Effects of Neural
      Glides Versus Proprioceptive Neuromuscular Facilitation in Terms of Joint Position Sense and
      Pain in Cervical Radiculopathy . so that we can have best treatment option for patients with
      cervical radiculopathy
    

Detailed description: 
      non probability convenient sampling was done. patients following eligibility criteria from
      Madina Teaching Hospital FSD and Kadijatulkubra hospital Chiniot. Non Probability Convenient
      sampling was done. Sample size was calculated with G power. 28 Participants were randomly
      allocated in two groups equally via convenient sampling method. Baseline assessment was done
      initially. Group A was given neural glides and Group B was given PNF along with conventional
      physiotherapy treatment (hot pack and traction). Duration of research was almost 6 months.
      Intervention was applied for 4 weeks, 3 sessions per week. Pre and Post treatment readings
      were taken in 1st and 4th week session Assessment was done via Numeric Pain Rating Scale;
      NDI, CVA and JPE as subjective measurements. All participants were provided written informed
      consent prior to commencement of the procedures. They were free to quit the treatment at any
      stage of research. Data was analyzed by using SPSS version 23.
    

Intervention name(s): Neural Glide; Rhythmic stabilization technique
Intervention type(s): Other; Other
Intervention description(s): hot pack and cervical traction is applied for 10-15 min.Group A received Neural mobilization of median nerve which includes gliding and sliding was given,therapist stood on the patient & affected side besides the patient, patient'S shoulder was depressed with one hand and elbow was moved in 90 degree flexion, forearm supination, extend the wrist and fingers with other hand. Then patient arm was moved into 90 degree abduction and then sliding or gliding of nerve was applied. Sliding was applied with elbow extension and wrist flexion and elbow flexion with wrist extension. 6 sets were performed. Each set was performed for 60 seconds, for alternative days in week for 4 weeks and then progressed to gliding/tensioning technique when symptoms improved; This group was receiving (PNF) Rhythmic stabilization technique with base line treatment.
Subject was lying in spine position on the treatment table and therapist resist an isometric contraction of agonist muscle group.pt maintain this position for 10 sec without trying to move and 12-15 repetitions were performed with 30 sec rest. Each therapeutic session treatment was focused on facilitation of neck stabilizers, improving neck stability, coordination, decreasing pain and improving postural control
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Safety and Tolerability of Metronidazole Gel 1.3%
Condition: Vaginosis, Bacterial
MeSH terms: Vaginosis, Bacterial; Vaginal Diseases
Study type: Interventional
Phase: Phase 4

Summary: 
      Multicenter, open-label study to evaluate safety and tolerability of Metronidazole Vaginal
      Gel in females 12 to <18 years for the treatment of bacterial vaginosis.
    

Detailed description: 
      A multicenter, open-label study to evaluate safety and tolerability of Metronidazole Vaginal
      Gel 1.3% when administered as a single dose in adolescent females (aged 12 to <18 years) for
      the treatment of bacterial vaginosis.
    

Intervention name(s): Metronidazole Gel
Intervention type(s): Drug
Intervention description(s): Metronidazole Vaginal Gel 1.3% administered via applicator
Other intervention name(s): Metro Gel
Intervention MeSH terms: Metronidazole
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic Women
Condition: Melasma
MeSH terms: Melanosis
Study type: Interventional
Phase: Phase 4

Summary: 
      This study will enroll 20 adult Hispanic women. Participants will apply 4% hydroquinone cream
      twice daily to affected areas on the face for 14 weeks and half the face will be peeled with
      20-30% salicylic acid every two weeks for a total of 4 peels. The first two peels will be 20%
      salicylic acid and the second two peels will be with 30% salicylic acid. The purpose of the
      study will be to evaluate the safety and efficacy of salicylic acid combined with 4%
      hydroquinone versus 4% hydroquinone alone.
    


Intervention name(s): 20-30% Salicylic Acid peels to the right side of the face; 20-30% Salicylic Acid peels to the left side of the face
Intervention type(s): Drug; Drug
Intervention description(s): Two 20% salicylic acid peels two weeks apart followed by 2 30% salicylic acid peels two weeks apart to the right side of the face.; Two 20% salicylic acid peels two weeks apart followed by 2 30% salicylic acid peels two weeks apart to the left side of the face
Other intervention name(s): Chemical Peels; Chemical Peels
Intervention MeSH terms: Salicylic Acid; Salicylates
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Melasma; Dark spots on the face
Clinical Efficacy of Cryolipolysis on the Fat of Thigh in Korean Women
Condition: Lipolysis; Cryotherapy Effect
Study type: Interventional

Summary: 
      The aim of this study is to evaluate the clinical efficacy of reduction of local fat on
      ipsilateral thigh through cryolipolysis (zeltiq) and controlateral thigh using by amplitude
      modulated frequency (conventional) method.
    

Detailed description: 
      Cryolipolysis is a new concept to reduce fat since Zeltiq machine had been introduced several
      years ago. Several different trials such as high frequency, liposuction and chemical
      lipolysis to remove fat had been emerged and tried. Therefore, we would like to know the
      clinical efficacy of cryolipolysis through comparative experiment with former frequency
      method on each thigh on healthy Korean women.

      Healthy premenopausal women who want to reduce the fat on thigh were included. 28 healthy
      volunteered women recruited for this study, 15 subjects among participated after
      interviewing, sampling their metabolic variables at initial visit. A total of 15 subjects
      would be investigated through food diary(24hour), femoral CT, anthropometric, metabolic
      variables at initial, 4th, 12th week. Histological examination under skin(initial and 12th
      week), questionnaire(4th, 12th week) for satisfaction, adverse events would be monitored
      during 3 month.
    

Intervention name(s): zeltiq; electrical stimulation
Intervention type(s): Device; Device
Intervention description(s): Cryolipolysis had been conducted for targeted fat area on thigh for 1 hour through Zeltiq machine made in Zeltiq Aesthetics.; Lipolysis would be done on controlateral thigh for 30 minutes through 3000 Hz- amplitude modulated frequency.
Other intervention name(s): zeltiq, cryolipolysis; electrical frequency
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: cryolipolysis; fat; thigh; Korean women
Kinesio Taping Compared to Exercise Intervention for Round Shoulder Subjects With Impingement Syndrome
Condition: Shoulder Impingement Syndrome (SIS); Round Shoulder Posture (RSP)
MeSH terms: Shoulder Impingement Syndrome; Syndrome; Rotator Cuff Injuries
Study type: Interventional

Summary: 
      To compare the effect between the exercise intervention (strengthening exercise and
      stretching exercise) and exercise intervention with taping on decreasing round shoulder
      posture and improving symptoms in subjects with shoulder impingement syndrome/round shoulder
      syndrome.
    

Detailed description: 
      Background: Poor posture and abnormal scapular kinematics have been suggested as possible
      primary factors in developing Shoulder impingement syndrome (SIS) and also as secondary
      observed phenomena of SIS. Round shoulder posture (RSP) is major and common posture
      contributing to increase the potential for subacromial impingement or exaggerate the symptoms
      of SIS. Objective: To compare the effect between the exercise intervention (strengthening
      exercise and stretching exercise) and exercise intervention with taping on decreasing RSP and
      improving symptoms in subjects with SIS/RSP. Methods: Forty subjects with impingement age
      between 20 and 75 are recruited and measured on acromial distance, pectoralis minor index
      (PMI), posterior and anterior shoulder tightness, distance of scapular medial border, pain
      score and flexilevel scale of shoulder function (FLEX-SF). Clinical significance: Shoulder
      impingement syndrome (SIS) have been identified as the majority of reported shoulder
      complaints. The project will provide an effective intervention for subjects with SIS/RSP.
    

Intervention name(s): kinesio taping; exercise
Intervention type(s): Other; Other
Intervention description(s): Apply exercise and kinesio taping for intervention; Apply only exercise intervention
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Shoulder impingement syndrome; Kinesio tape; Round shoulder posture
Assisting Obsessive Compulsive Disorder (OCD) Patients With Discontinuing Long-term Serotonin Reuptake Inhibitors (SRIs)
Condition: Obsessive Compulsive Disorder
MeSH terms: Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Study type: Interventional

Summary: 
      This study will address questions of fundamental clinical significance including: (1) whether
      OCD patients maintained on long term SRIs can be discontinued without symptom exacerbation,
      (2) whether trans-diagnostic cognitive-behavioral treatment will reduce worsening following
      discontinuation compared to Taper and Monitoring, and (3) whether predictors of successful
      SRI discontinuation can be identified.
    


Intervention name(s): Unified Protocol (UP); Taper and Monitoring (TAP-M)
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Efficacy of the Electronic Acupuncture Shoes: A Clinical Trial for Chronic Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      This randomized , double-blind, parallel-arm clinical trial was designed to study the
      efficacy and safety of the "Electronic Acupuncture Shoes" treatment on chronic low back pain
      patients.

      Chronic low back pain patients, aged 20-60, of both gender were recruited. As the primary
      outcome measure to assess the efficacy, "0-10 numerical rating scale" was used. Secondary
      outcome measure included the speed of pain-relief.

      The number of samples in the experimental group and the control group ratio of 1 : 1 , is
      expected to total effective sample number is 60 . Experimental group will receive a six-week
      "Electronic Acupuncture Shoes" treatment and a week back to the clinic three times , subject
      to a total of 18 treatments , each course of about one hour . Subjects will take NSAID
      placebo in the first week of the course of treatment . After the second week of NSAID placebo
      on disabled.

      Control subjects will also accept the six- week treatment , control subjects will be equally
      back to the clinic three times a week , each group will be given to the subject of one hour
      each shoe pseudo electrotherapy treatment group and control group run by entering from the
      test day in the first week of the course , each taking ibuprofen 400mg, taken three times a
      day , the second week after the NSAID drugs on disabled.
    


Intervention name(s): Electronic Acupunture Shoes; Ibuprofen
Intervention type(s): Device; Drug
Intervention description(s): Experiment group receives a one-hour treatment given by "Electronic Acupuncture Shoes" three times a week. 6 weeks of treatment was given.
Control group received the six-week treatment as well, yet the subjects received pseudo electrotherapy.; Experiment group took placebo only in the first week. Control group took ibuprofen(400mg, TID) only in the first week. No more placebo or medicine was prescribed to either two groups since the second week.
Intervention MeSH terms: Ibuprofen
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Physician-Based Trial to Increase Colorectal Cancer Screening in Chinese
Condition: Colorectal Cancer
MeSH terms: Colorectal Neoplasms
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The objective of this study is to test whether a culturally-tailored in-office based
      intervention have impact on increasing Chinese physician's recommendation of colorectal
      cancer (CRC) screening to their nonadherent Chinese patients.

      Special aims are to:

        1. Evaluate the efficacy of a culturally-tailored physician intervention on increasing
           non-adherent Chinese American's patients' CRC screening rate.

        2. Identify factors that mediate or moderate the intervention effects. For example,
           patients who hold an eastern cultural view or are less acculturated will be more likely
           to benefit from the intervention than patients who hold a western view or who are more
           acculturated.
    

Detailed description: 
      This study is a randomized controlled trial aiming to test the effect of the
      culturally-tailored in-office based intervention on physicians. A total of 24 Chinese
      physicians in the Washington DC and Philadelphia areas and a total of 24 eligible Chinese
      patients from each physician will be recruited for this study. Physicians and their patients
      are randomized into two groups: A and B. Physician in the intervention group (A) will receive
      mailed printed materials including a CRC physician guide, patient brochure, flip chart and a
      poster and two sessions of in-office training aimed to reinforce learning of the topic
      covered by the mailed materials and provide physicians with hands-on experience in using
      communication skills with standardized patients. Physicians in the control group (B) will
      receive nothing until the end of the study. Patients will be followed 12-month later after
      their completion of the baseline survey and their self-reported CRC screening status will be
      verified by chart audit.
    

Intervention name(s): Mailed printed materials and in-office training
Intervention type(s): Behavioral
Intervention description(s): Mailed printed materials including CRC physician guide, patient brochure, flip chart and a poster
Two sessions of in-office training with two standardized patients
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: colorectal cancer screening; Chinese Americans; patients nonadherent with CRC Screening