EFFECT OF TREADMILL TRAINING ON BALANCE AFTER CHEMOTHERAPY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
Condition: Acute Lymphoblastic Leukemia, Pediatric
MeSH terms: Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Lymphoid
Study type: Interventional

Summary: 
      Purpose: The present research was conducted to study the effect of treadmill training on
      balance after chemotherapy in children with acute lymphoblastic leukemia.

      Subjects and Methods: Forty children with acute lymphoblastic leukemia included in the
      current research ranged of age from 8 to 12 years. The children participated in this study
      were assigned randomly into two equal number groups (A and B). Group (A) includes 20 children
      who received balance exercises, while group (B) includes 20 children who received the same
      balance exercises of group (A) and treadmill training. The treatment program was applied
      three sessions per week (60 min for every session) for 8 weeks. Balance Master System and
      Biodex Balance System were used to evaluate balance of all children in the three groups
      before and after the treatment program.
    

Detailed description: 
      The current research is a randomized control trial to differentiate between the treadmill
      training on balance after chemotherapy in children with acute lymphoblastic leukemia.
      Chemotherapy induced peripheral neuropathy is related to the intensity of treatment and
      dosage of chemotherapy which could affect the severity of its symptoms, it could result in
      serious problems like sensory changes and numbness , in case the sensory nerves were affected
      , muscle weakness and in-coordination in case the affected were the motor nerves. In addition
      to the psychological problems the patient experience as a result of CIPN, the patient also
      experience physical problems like injuries, fear of fall results from lack of sensory
      perception and muscle power. Treadmill training, motor training may favor proprioceptive
      feedback, leading to adjustments for adequate postural balance and functional performance.
      Treadmill exercises stimulate the kinetic, kinematic, and temporal features of walking. These
      exercises improve the strength of the muscles of the lower extremities, enhance motor
      learning, improve functional abilities, and activate the locomotor control system
    

Intervention name(s): Balance exrcises; Balance exrcises and Treadmill training
Intervention type(s): Other; Other
Intervention description(s): the group (20 children) received traditional exercise program with instructions given to the children for 60 min aiming to improve posture control and balance. Tools of traditional physical therapy exercises were; special tools were used for traditional physical therapy exercises include vestibular board, rolls of different sizes, blocks and wedges of different heights; the group (20 children) received the same traditional physical therapy program as the same applied in group of balance exercises, in addition to treadmill training (30 min). The child walked on the treadmill (motorized treadmill, ENTRED, Enraf-Nonius) at 75% of over-ground speed and individually prescribed low-endurance walking at 0% incline for 20 min, three times a week for 8 successive weeks. The walking area of the treadmill is made from heavy steel with a minimum 8-inch thickness and is available with cushioning in case of accidental impacts. Before the walking session, each child underwent 5 min of active stretching exercises that include prolonged and progressive stretching of the hamstrings, quadriceps muscles, and Achilles tendon.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment