bioihbjkbjnl/mcl2 huggingface dataset:
Understanding Changes in Heart Function After Exercise in People With Stroke
Condition: Stroke
MeSH terms: Stroke
Study type: Interventional

Summary: 
      Little is known about how exercise can affect heart function in stroke survivors.

      This study will look at changes in cardiovascular fitness and function after 6 months of
      exercise. Volunteers will be tested before and after the program and again 2 months later to
      measure the effects on stroke risk factors, fitness level and flexibility of the arteries.
      Blood tests will measure cholesterol levels and other signs of inflammation.

      This study will help us better understand how exercise after stroke can improve heart
      function and heart health, and ultimately help in lowering future stroke risk.
    

Detailed description: 
      Purpose

      To determine the effects of aerobic exercise after stroke on cardiorespiratory fitness,
      cardiovascular function, stroke risk factors, walking and health-related quality of life.
      This study will also examine the retention of these effects after the exercise program ends.

      Methods

      A randomized controlled study design will be used. Sixty participants will be randomized to
      participate in one of 2 treatment arms (6 months duration, 3 days / week, 1 hour / session):

        1. BALANCE AND FLEXIBILITY (non-aerobic) PROGRAM will be comprised of individualized upper
           and lower body stretching, or balance activities, yoga- or Tai Chi-style classes.

        2. AEROBIC PROGRAM will be comprised of a structured, progressive aerobic training program.

      Participants will be evaluated at 3 time points - baseline (0 months), post-intervention (6
      months) and follow up (8 months) - for stroke risk factors, cardiorespiratory fitness,
      arterial stiffness, echocardiography measures, inflammatory biomarkers, ambulatory capacity
      and health-related quality of life.
    

Intervention name(s): Aerobic Exercise Program; Non-aerobic Exercise Program
Intervention type(s): Behavioral; Behavioral
Intervention description(s): The AEROBIC PROGRAM will be the Experimental arm of this trial. It will be a structured, progressive aerobic training program that will be 6 months in duration. Classes will be held 3 times / week, for 1 hour / session.; The BALANCE AND FLEXIBILITY (non-aerobic) PROGRAM will be the Active Comparator arm of this trial. It will be comprised of upper and lower body stretching, or balance activities, yoga- or Tai Chi-style classes. This program will be 6 months in duration. Classes will be held 3 times / week, for 1 hour / session.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Stroke; Exercise; Rehabilitation; Risk factors
Low Doses Amitriptyline & Chronic Neck Pain
Condition: Neck Pain
MeSH terms: Neck Pain
Study type: Interventional
Phase: Phase 4

Summary: 
      The objective of this prospective randomized and controlled study is to evaluate the efficacy
      and safety of low dose of amitriptyline (5 mg) in the management of chronic neck pain.
    

Detailed description: 
      Patients with chronic neck pain, lasting since at least 3 months, are recruited from our pain
      clinic. After verification of inclusion and exclusion criteria, patients consenting to enter
      the study are assigned randomly to one of the following groups: 1-Amitriptyline 5 mg for 2
      months 2- placebo for 2 months. Co-morbidities and other painful conditions are noted, and
      then clinical evaluation of the patient is performed; pain is assessed according to Visual
      Analog Scale, anxiety, depression, insomnia and disability are evaluated by adapted scores
      (Bergen insomnia scale, neck pain disability score, neck pain diary & anxiety and depression
      score). Patients are followed at 2 months and outcome measures are assessed.
    

Intervention name(s): Amitryptiline; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Amitryptiline 5 mg before bedtime for 2 months; Placebo pill
1 before bedtime
Other intervention name(s): Tryptizol; Laroxyl; No brand name
Intervention MeSH terms: Amitriptyline
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Keywords: amitryptiline; Chronic pain; Neck pain
Weightlifting Belts and Wrist Straps for Weightlifters
Condition: Exercise Movement Techniques
Study type: Interventional

Summary: 
      Objective: This study examined the effects of weightlifting belts and wrist straps on the
      kinematics of the deadlift exercise, time to complete a deadlift and rating of perceived
      exertion (RPE) in male recreational weightlifters.

      Methods: Twenty participants used various combinations of belt and straps during a
      conventional deadlift. The hip and knee flexion, cervical lordosis, thoracic kyphosis and
      lumbar lordosis angles and time to complete a deadlift were measured using video analysis
      software. RPE was also recorded.
    


Intervention name(s): Weightlifting belts and wrist straps
Intervention type(s): Device
Intervention description(s): The participants wore a weightlifting belt (Heavywear Nylon Contour Belt H9, North Carolina, USA) for the "with weightlifting belt" conditions and/or put on a pair of wrist straps (Versa Gripps Professional Series, Versa Gripps, Maine, USA) for the "with wrist strap" conditions. The steps involved in completing a conventional deadlift have been detailed in Holmes.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Low-dose GH Supplementation Increases Clinical Pregnancy Rate
Condition: Infertility
MeSH terms: Infertility
Study type: Interventional
Phase: Phase 1

Summary: 
      The objective of this study is to assess whether a low dose of GH supplementation (0.5
      IU/day) increases clinical pregnancy rates in women with a history of POR who failed to
      become pregnant in two previous IVF cycles.
    

Detailed description: 
      The investigators aim to study the impact of a low-dose growth hormone (GH) supplementation
      in pregnancy rates in poor responders in a prospective, self-controlled study of 64 poor
      responders to previous IVF cycles who failed to achieve pregnancy and were supplemented with
      low-doses of GH in a subsequent cycle using the same gonadotropin dose and protocol. Our
      primary endpoint was the clinical pregnancy rate (CPR), considering secondary endpoints the
      number of retrieved oocytes, embryos, embryo quality and the proportion of cycles with embryo
      transfer.

      Controlled ovarian hyperstimulation will be performed using a GnRH agonist long protocol from
      day 21-23 of the menstrual cycle at a dose of 1 mg/ day, using the same schedule and dose as
      in the previous cycle, so that the only difference between them is the GH supplementation.

      After confirming pituitary inhibition, the dose of GnRH agonist will be decreased to 0.5
      mg/day, and COH will begin with gonadotropins at a dose of 300 UI, subsequently adjusting
      according to clinical response. Human chorionic gonadotropin (hCG) will be administered when
      follicles reached > 17 mm in diameter. A dose of 0.5 IU of GH will be administered daily from
      the first day of the agonist until the day of hCG administration. Oocyte retrieval will be
      performed 36 hours after hCG administration by ultrasound-guided follicle aspiration.
    

Intervention name(s): Growth Hormone
Intervention type(s): Drug
Intervention description(s): A dose of 0.5 IU of growth hormone will be administered daily from the first day of the agonist until the day of hCG administration
Other intervention name(s): Somatotropin
Intervention MeSH terms: Hormones
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Poor ovarian response; IVF; Growth hormone
A Multiple Ascending Dose Study of Safety and Pharmacokinetics of NP10679 in Normal Healthy Volunteers
Condition: Stroke, Ischemic; Pain, Postoperative; Substance Abuse; Subarachnoid Hemorrhage
MeSH terms: Subarachnoid Hemorrhage; Ischemic Stroke; Hemorrhage; Pain, Postoperative; Substance-Related Disorders
Study type: Interventional
Phase: Phase 1

Summary: 
      This multiple ascending dose study assesses the safety, tolerability and pharmacokinetics of
      NP10679 when delivered intravenously in escalating dose levels in comparison to placebo.
    

Detailed description: 
      NP10679 is a pH dependent inhibitor of the GluN2B subtype of the NMDA receptor. Compounds of
      this drug class are hypothesized to be beneficial in a number of central nervous system
      disorders, including brain ischemia associated with stroke, subarachnoid hemorrhage, severe
      pain, major depression and substance abuse disorders. This study uses a double blind,
      adaptive design approach to evaluate the safety, tolerability and pharmacokinetics of 5 once
      daily doses of NP10679 when delivered intravenously in three escalating dose levels in
      comparison to placebo
    

Intervention name(s): Placebo; NP10679
Intervention type(s): Drug; Drug
Intervention description(s): Placebo via 30 minute infusion once daily for 5 days; NP10679 25 mg via 30 minute infusion once daily for 5 days
Allocation: Randomized
Intervention model: Sequential Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: NMDA; GluN2B
Efficacy and Safety Study of Adalimumab in the Treatment of Hidradenitis Suppurativa
Condition: Hidradenitis Suppurativa (HS)
MeSH terms: Hidradenitis Suppurativa; Hidradenitis
Study type: Interventional
Phase: Phase 3

Summary: 
      A study to evaluate the safety and efficacy of treatment with adalimumab in adults with
      moderate to severe hidradenitis suppurativa (HS).
    

Detailed description: 
      The clinical trial identifier is PIONEER II. The purpose of this study is to evaluate the
      safety of adalimumab and to determine how well it works in the treatment of adults with
      moderate to severe HS. HS is a chronic skin disease that creates red, swollen, painful bumps
      which can break open to combine and form tunnels in the skin and scars. Sometimes these bumps
      can heal themselves quickly and sometimes they will become much worse and create sores that
      heal with multiple combined scars, or areas that do not heal. In this study, approximately
      300 adults will be enrolled at treatment centers worldwide. Subject participation in this
      study will be up to 50 weeks. There will be a screening period, which will last from 7 to 30
      days, and a study treatment period of up to 36 weeks. Study visits occur at Screening,
      Baseline, and Weeks 2, 4, 8, 12, 14, 16, 20, 24, 28, 32 and 36 (or sooner if subject leaves
      the study before Week 36). The study is divided into two treatment periods. The first period
      (Period A) will last 12 weeks and the second period (Period B) will last 24 weeks.
    

Intervention name(s): adalimumab; placebo
Intervention type(s): Biological; Biological
Intervention description(s): Adalimumab pre-filled syringe, administered by subcutaneous injection; Placebo pre-filled syringe, administered by subcutaneous injection
Other intervention name(s): Humira
Intervention MeSH terms: Adalimumab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: placebo controlled; double blind; adalimumab; TNF; psoriasis; HS; PIONEER II; hidradenitis suppurativa; acne inversa; boil; acne
Heart Rate Variability Assessment in Dialysis Patients by Acupuncture
Condition: RLS
Study type: Interventional

Summary: 
      Title of the study:Heart Rate Variability Assessment in Dialysis Patients by Acupuncture

      Study period: 08/2019 - 07/2021

      Institution: the Graduate Institute of Chinese Medical Science, China Medical University/
      Changhua Christian Hospital,Taiwan

      Aim of the study: To investigate the effect of medical acupuncture in comparison to placebo
      acupuncture by heart rate variability(HRV)

      Design: Prospective randomized trial

      Intervention: Experiment group using indwelling fixed needles, N=30 ; Control group using
      placebo needles, N=30

      Outcome measures: International RLS Rating Scale, HRV
    

Detailed description: 
      RLS occurs in 3-15% of the general population and in 10-30% of patients on maintenance
      dialysis. End-stage renal disease, a decrease in HRV is typically found, with abnormal HRV
      being considered an independent risk factor for mortality.While the majority of studies show
      an initial improvement in symptoms, longer studies and clinical experience show that either
      treatment efficacy decreases with time, and/or augmentation develops: dopaminergic
      augmentation has been reported to be the main reason for treatment discontinuation and
      treatment failure in RLS/WED.

      The study randomly assigned to either true acupuncture treatment or placebo/sham acupuncture
      treatment. Each participant will undergo 12 treatments third-weekly, for a period of 4 weeks.
      At the end of the eighth treatment session, each participant will again fill out a IRLSRS
      questionnaire ,ISI and HRV test. At the end of the treatment regimen and 5weeks, participants
      will again fill out a IRLSRS questionnaire ,ISI and HRV test.
    

Intervention name(s): Acupuncture needle with electrical stimulation; Sham electroacupuncture
Intervention type(s): Other; Other
Intervention description(s): EA is treated for 4 weeks, 3 times per week.; Sham EA is treated for 4 weeks, 3 times per week.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Corifollitropin Alfa on D5 Versus D7 After Contraceptive Pill
Condition: Oocyte Donation
Study type: Interventional
Phase: Phase 4

Summary: 
      To evaluate if the administration of corifollitropin alfa on day 7 instead of on day 5 after
      pre-treatment with oral contraceptive pill results in a reduced total rFSH (recombinant
      follicle stimulating hormone ) consumption in a GnRH antagonist protocol in donors.
    


Intervention name(s): Corifollitropin alfa
Intervention type(s): Drug
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Corifollitropin alfa; Stimulation protocol
The Study of Wuling Capsule in Treatment Chronic Tinnitus
Condition: Tinnitus, Subjective
MeSH terms: Tinnitus
Study type: Interventional

Summary: 
      To evaluate the effect of psychological/mental factors on the severity of subjective
      tinnitus, to observe the efficacy and safety of Wuling capsule in the treatment of chronic
      subjective tinnitus with emotional disorders, and to evaluate the control rate of tinnitus
      complications, such as depression, anxiety and insomnia, and the improvement of
      patients'quality of life.
    

Detailed description: 
      To evaluate the effect of psychological/mental factors on the severity of subjective
      tinnitus, to observe the efficacy and safety of Wuling capsule in the treatment of chronic
      subjective tinnitus with emotional disorders, and to evaluate the control rate of tinnitus
      complications, such as depression, anxiety and insomnia, and the improvement of
      patients'quality of life. Patients with chronic tinnitus complicated with mild to moderate
      anxiety or depression were randomly divided into two groups. The experimental group was given
      oral treatment with Wuling capsule, and the control group was given gurusu treatment. The
      improvement of tinnitus, sleep, anxiety and depression in patients was evaluated at 2,4 and 8
      weeks after treatment, respectively, and the efficacy of Wuling capsule in improving tinnitus
      combined with anxiety, depression and tinnitus was analyzed。
    

Intervention name(s): Wuling Capsule; Oryzanol
Intervention type(s): Drug; Drug
Intervention description(s): take Wuling Capsule in experiment group for 2 months; take oryzanol in active comparator group for 2 months
Other intervention name(s): Ginaton; Ginaton
Intervention MeSH terms: Gamma-oryzanol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Investigation of the Effect of Scan Delay on the Measurement of Dental Prescale II
Condition: Bite Force; Scan Delay
Study type: Interventional

Summary: 
      Dental Prescale II (GC Corp., Tokyo) is a pressure sensitive sheet for occlusal force
      measurement. According to the instruction, the patient need to bite the sheet for about 3
      seconds and then the sheet will be scanned. But the delay response of coloring agent will
      influence the data collected and was noticed in vitro. To have a standard procedure, we need
      to know the time for scanning. This study will scan the sheet up to 2 hours and try to find
      the relation between the time the sheet scanned and the data collected.
    


Intervention name(s): Dental Prescale II
Intervention type(s): Device
Intervention description(s): The participant will bite Dental Prescale II for about 3 seconds, using a force for " chewing beef ". And the Dental Prescale II will be taken out from the mouth. Then the trial is end.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Screening
Keywords: Dental Prescale II,Scan Delay
Effects of Medications in Patients With Hypogonadism
Condition: Idiopathic Hypogonadotropic Hypogonadism
MeSH terms: Hypogonadism
Study type: Interventional
Phase: Phase 4

Summary: 
      The aim of the present study was to demonstrate the influences of three different treatment
      strategies on biochemical parameters and testicular volume (TV) in patients with idiopathic
      hypogonadotropic hypogonadism (IHH).
    


Intervention name(s): Testosterone enanthate (Sustanon 250 mg); Human chorionic gonadotropin (hCG) (Pregnyl 5000 IU); Testosteron gel (Testojel 50 mg)
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Twenty-eight patients were treated with testosterone enanthate (TE),; twenty-five patients were treated with human chorionic gonadotropin (hCG); Twenty-four patients were treated with testosterone gel (TG).
Intervention MeSH terms: Methyltestosterone; Chorionic Gonadotropin; Testosterone; Testosterone undecanoate; Testosterone enanthate; Testosterone 17 beta-cypionate
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: hypogonadism; treatment; testis volume
Mechanisms of Exercise-induced Bronchospasm
Condition: Exercise-induced Bronchospasm
MeSH terms: Bronchial Spasm; Asthma, Exercise-Induced
Study type: Observational

Summary: 
      The term exercise-induced bronchospasm (EIB) describes acute, transient airway narrowing that
      occurs during, and most often after, exercise. Manifestations of EIB can range from mild
      impairment of performance to severe bronchospasm and respiratory failure.

      The pathogenesis of EIB remains controversial and the role of airway inflammation has not yet
      been definitively characterized. We plan on comparing markers of inflammation in asthmatic
      participants with and without EIB at baseline and after bronchoprovocation with eucapnic
      voluntary hyperventilation testing (EVH). We also will collect demographic information as
      well as information about asthma control and exercise habits.
    

Detailed description: 
      At Visit 1, participants will complete questionnaires about demographics, asthma control (if
      asthmatic) and exercise habits. The participants will have baseline spirometry performed, and
      skin prick testing for allergies. Skin testing is important as it can influence the level of
      exhaled nitric oxide and hence we would like to adjust our results for the presence of
      allergies. Subsequently, volunteers will undergo sputum induction and then have peripheral
      blood drawn for microRNA analysis. MicroRNA's are single-stranded RNA molecules of about
      21-23 nucleotides in length regulating gene expression. Patterns of MicroRNA expression have
      been linked to heart disease and cancer. Similar patterns have not been identified in
      exercise-induced asthma. In total, including time for questions and recovery, the time for
      Visit 1 will be approximately 3 hours.

      At Visit 2, which will occur 24 hours to 7 days after Visit 1 in order to minimize risk of
      asthma exacerbation, the participants will again have baseline spirometry. Baseline exhaled
      nitric oxide will be performed. Eucapnic Voluntary hyperventilation testing will then be
      performed. They then will have a second exhaled nitric oxide quantification, will undergo
      sputum induction and then have peripheral blood drawn for microRNA analysis, all occurring
      after EVH testing. In total, including time for questions and recovery, the time for Visit 2
      will be approximately 2 hours.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        EIB is one of the most common triggers of bronchospasm in asthmatics. It is identified as a
        trigger in 80-90% of asthmatics. It also occurs frequently (10-15%) in healthy volunteers
        without asthma. Inclusion of a heterogenous population of asthmatics and non-asthmatics
        will help provide much needed information to help compare/contrast EIB that occurs in these
        two groups.
      
Biospecimen description: 
      blood, sputum, urine for pregnancy testing
    
Keywords: inflammation in asthmatic and non-asthmatic participants