bioihbjkbjnl/mcl2 huggingface dataset:
Efficacy of Segmental Examination Twice of the Proximal Colon on Adenoma Detection
Condition: Colonic Polyps
MeSH terms: Adenoma; Colonic Polyps
Study type: Interventional

Summary: 
      Segmental examination twice of the proximal colon might be helpful to increase adenoma
      detection rate (ADR).
    

Detailed description: 
      Colonoscopy is the gold standard screening test for colorectal cancer (CRC). Removal of
      adenomas can reduce the incidence and mortality of CRC. However, there is evidence that some
      patients may develop interval cancers-cancers developed within 3-5 years following
      colonoscopy and polypectomy. The overall rate of interval cancer was 1.1-2.7 per 1000
      person-years. Several studies have suggested that patients who develop interval cancers are
      more likely to have proximal compared than distal cancers.

      One hypothesis is that adenomas may be more likely to be missed in the proximal colon
      compared with the distal colon. Serrated polyps and some adenomas in the proximal colon may
      be difficult to detect if they are flat, covered with mucus, or behind folds. A second
      hypothesis is that neoplastic lesions of the proximal colon may biologically differ from
      distal lesions and progress to malignancy with a short dwell time.

      Several tandem back to back colonoscopy studies have demonstrated that up to 27% adenomas in
      the proximal colon are missed during routine screening colonoscopy. Hover, examining the
      colon twice as that in the back to back studies is difficult to be performed in clinical
      practice. Thus, we developed a novel colonoscopy technique, segmental examination twice of
      the proximal colon, that is simple and easy to be performed. The current study aims to
      examine the efficacy of segmental examination twice of the proximal colon on adenoma
      detection rate (ADR) during routine screening and surveillance colonoscopy.
    

Intervention name(s): Extending withdrawal time in the proximal colon; Segmental examination twice of the proximal colon
Intervention type(s): Procedure; Procedure
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Adenoma detection rate; Colonoscopy; Withdrawal time
Arthroscopic Partial Meniscectomy Versus Exercise Therapy for Meniscal Injuries in Older Patients, a 5 Year Follow up.
Condition: Meniscus Tear, Tibial; Osteoarthritis, Knee
MeSH terms: Osteoarthritis, Knee; Tibial Meniscus Injuries
Study type: Interventional

Summary: 
      Arthroscopic partial meniscectomie (APM) offers little short-term to medium-term benefit
      above sham surgery or non-surgical management for knee function in most patients with a
      symptomatic degenerative meniscus tear. It is suggested that APM is associated with increased
      risk of accelerated progression of knee osteoarthritis in middle-aged to older patients.

      With the 5 year follow-up of the ESCAPE trial we will investigate the longterm results of APM
      and physical therapy in patients with a meniscal tear over 45 years old.
    


Intervention name(s): arthroscopic partial meniscectomy; Physical therapy
Intervention type(s): Procedure; Other
Intervention description(s): In the surgery group, the orthopaedic surgeon performed an arthroscopic partial meniscectomy within 4 weeks after allocation. The surgeon removed the damaged part of the meniscus, until a stable and solid meniscus remained. All patients received written post-operative instructions. Eight weeks after surgery, patients received a consult in the outpatient orthopaedic clinic. In agreement with the Dutch Orthopaedic Association Guidelines, patients were referred to physical therapy when signs of abnormal recovery were present.; The treatment protocol consisted of a physical therapist-led incremental exercise program over a period of eight weeks, containing 16 sessions of 30 minutes each.
Other intervention name(s): meniscal surgery; APM; exercise therapy
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Treatment of Chronic Postherpetic Pain With Fat Grafting
Condition: Post Herpetic Neuralgia; Herpes Zoster
MeSH terms: Herpes Zoster; Neuralgia; Neuralgia, Postherpetic
Study type: Interventional

Summary: 
      This study evaluates the possible beneficial effect of fat grafting for post herpetic
      neuralgia.
    

Detailed description: 
      Herpes Zoster (HZ),is a condition caused by Varizella-Zooster virus (VZV), The disease is
      caused by reactivation of a latent VZV-infection in the sensory ganglia.

      Clinically the condition is characterized by a painful, unilateral, vesicular rash. Pain is
      the most prominent symptom in around 90% of patients. In 10% of patients this pain remains
      and becomes chronic.

      Post-herpetic neuralgia is a chronic pain syndrome that occurs after the dermal
      manifestations disappears.

      Treatment is complex and mainly topical or systemic. For many patients this is not sufficient
      and they live with constant pain.

      Fat grafting has shown promise in treating several different painful conditions such as post
      mastectomy pain syndrome, painful scars etc.

      This study investigates is PHN can be treated by fat grafting.
    

Intervention name(s): Fat grafting
Intervention type(s): Procedure
Intervention description(s): The area of dermal pain is identified and marked prior to surgery. The surgery starts with liposuction, either on the abdomen or the thigh. The harvested fat is prepared for fat grafting by sedimenting it for 10 minutes. The fat is then injected into the painful area, marked pre-surgery.
Other intervention name(s): Fat transplant, lipofilling
Intervention model: Single Group Assignment
Intervention model description: The five patients included will all receive a fat graft in the area affected by PHN.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Chronic Pain; Herpes Zoster; Pain
Comparison of Two Thoracic Manipulation Techniques to Improve Neck Pain in Dentistry Students
Condition: Neck Pain
MeSH terms: Neck Pain
Study type: Interventional

Summary: 
      This study is designed to compare the short term effects of two different thoracic spine
      thrust manipulation techniques on neck range of motion, pain, and self-reported disability in
      a sample of dental students experiencing neck pain.

      The hypothesis of the study is that there will be a difference between the two thoracic spine
      thrust manipulation techniques for short term effects on neck range of motion, pain, and
      self-reported disability in a sample of dental students experiencing neck pain.
    


Intervention name(s): Thoracic Spine Thrust in Seated Position; Thoracic Spine Thrust in Supine Position
Intervention type(s): Other; Other
Intervention description(s): The thoracic spine manipulation used here is a manipulation technique that involves positioning the patient so that a small amplitude quick stretch can be applied to the least mobile area of the thoracic spine as identified by the licensed physical therapist during spinal segmental mobility testing.; The thoracic spine manipulation used here is a manipulation technique that involves positioning the patient so that a small amplitude quick stretch can be applied to the least mobile area of the thoracic spine as identified by the licensed physical therapist during spinal segmental mobility testing.
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Neck Pain; Thoracic spine thrust manipulation; Osteopathic Manipulation; Dentistry; Range of Motion
Cosmetic Appeal, HRQoL and Effectiveness of Simple and Pseudotesticular Techniques of Orchidectomy in Prostate Cancer
Condition: Prostate Cancer; Quality of Life; Orchiectomy
MeSH terms: Prostatic Neoplasms
Study type: Interventional

Summary: 
      The therapeutic efficacy of three types of orchidectomy was ascertained as well as the QoL
      and scrotal cosmetic satisfaction of patients in the three surgical arms. Two of these
      surgeries produced a pseudotesticle (BSCO, BESO) while one (BSO) did not.
    

Detailed description: 
      Patients with prostate cancer (PCa) were grouped into three surgical arms: BSO (bilateral
      simple orchidectomy), BSCO (bilateral subcapsular orchidectomy) and BESO (bilateral
      epididymal-sparing orchidectomy). Preoperatively, baseline serum testosterone, PSA, Quality
      of life (QoL) and pre-operative testicular volumes were obtained. Timed interval sampling for
      serum testosterone and PSA variation was done post-operatively. By three months post-op, the
      cosmetic appeal of the scrotal appearance, post-operative pseudotesticular volumes and QoL
      were also assessed.

      The therapeutic efficacy of the surgeries was determined by the rates of decline of serum
      testosterone and PSA, as well as the nadirs achieved. The variations in the pre-and
      post-operative QoL was analysed.
    

Intervention name(s): Bilateral simple orchidectomy (BSO); Bilateral Subcapsular Orchidectomy; Bilateral Epididymal-sparing Orchidectomy
Intervention type(s): Procedure; Procedure; Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Three groups of patients subjected to a type of orchidectomy each
Masking: Single (Participant)
Primary purpose: Other
Keywords: orchidectomy; pseudotesticle
Follow-up Trial of Rituximab Interferon Transplant Trial: Study Drug-Rituximab and Alpha Interferon
Condition: Lymphoma, Follicular
MeSH terms: Lymphoma, Follicular
Study type: Observational

Summary: 
      A previous phase II trial entitled Treatment of Follicular non-Hodgkin's Lymphoma with High
      Dose Therapy and Stem Cell Support Followed by Consolidative Immunotherapy with Rituximab and
      Alpha Interferon was conducted at the Odette Cancer Centre between 2005 and 2012. The primary
      objectives of this previous trial was to assess progression free survival and overall
      survival. Of the 36 patients in this trial, approximately 18 remain in remission. In this new
      follow up trial, follow up data will prospectively be collected on patients who provide
      informed consent to do so.
    


Intervention name(s): Follow up
Intervention type(s): Other
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Twelve patients with low grade follicular lymphoma who consented to long term follow-up and
        were previously treated with high dose therapy and autologous stem cell transplant with
        rituximab and alpha interferon as part of the phase II trial Treatment of Follicular
        Non-Hodgkin's Lymphoma with High Dose Therapy and Stem Cell Support Followed by
        Consolidative Immunotherapy with Rituximab and Alpha Interferon.
Safety Study That Compares Perlane to Perlane With Lidocaine (Perlane-L) While Correcting Wrinkles in the Area Around Your Nose
Condition: Nasolabial Folds
Study type: Interventional

Summary: 
      Safety study that compares Perlane to Perlane with Lidocaine while correcting wrinkles in the
      area around your nose.
    

Detailed description: 
      This is a split-face design. All 60 subjects receive Perlane on one side of their face, and
      Perlane-L on the other. Subjects and the investigator is blinded to which side of face
      receives which product. These are one time injections.
    

Intervention name(s): Perlane and Perlane-L
Intervention type(s): Device
Intervention description(s): This is a split face design and each subject received both Perlane-L and Perlane. Treatments were blinded, randomized, and successive.
Other intervention name(s): Each subject received both Perlane-L and Perlane.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Correction of Nasolabial Folds
CC-223 and Ketoconazole Drug-Drug Interaction Study
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a single-center open-label study to compare how CC-223 (the study drug being
      investigated) interacts with the drug ketoconazole.
    

Detailed description: 
      This is a 2 period study, which lasts about 6 weeks long. About 14 males will be entered into
      the study, during which they will receive the study drug (a single dose of 20 mg CC-223) 400
      mg ketoconazole.
    

Intervention name(s): CC-223; Ketoconazole
Intervention type(s): Drug; Drug
Intervention description(s): CC-223 20 mg tablets; Ketoconazole 400 mg tablets
Other intervention name(s): Nizoral
Intervention MeSH terms: Ketoconazole
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
A Study of LY3819253 (LY-CoV555) in Participants Hospitalized for COVID-19
Condition: COVID-19
MeSH terms: COVID-19
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to test the safety and tolerability of LY3819253 when it is
      given by injection into a vein to participants hospitalized with COVID-19. Blood tests will
      be done to check how much LY3819253 is in the bloodstream and how long the body takes to
      eliminate it. Participation could last about 8 weeks and may include up to 15 visits in the
      hospital or the home.
    


Intervention name(s): LY3819253; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Administered IV.; Administered IV.
Other intervention name(s): LY-CoV555; Bamlanivimab
Intervention MeSH terms: Bamlanivimab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Clinical Study to Evaluate Safety and Immunogenicity of Bacillus Calmette-Guerin (BCG) Delivery Via Novel Micronjet600 Device Compared to Those Via Conventional Needle
Condition: Tuberculosis; BCG Vaccination
MeSH terms: Tuberculosis
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate safety and immunogenicity of Bacillus
      Calmette-Guerin (BCG) delivery via Novel Micronjet600 device compared to those via
      conventional needle.
    

Detailed description: 
      This study is designed as prospective, randomized, open-label, single-centered. In this
      study, healthy adults who meet inclusion criteria will be randomized and receive a BCG
      vaccine either using a conventional needle or MicronJet600 device. After vaccination, adverse
      events and progress will be observed.
    

Intervention name(s): BCG vaccination with MicronJet600; BCG vaccination with conventional needle
Intervention type(s): Device; Device
Intervention description(s): BCG vaccination with MicronJet600; BCG vaccination with conventional needle
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Experimental: BCG vaccination with MicronJet600
Comparator: BCG vaccination with conventional needle
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Tuberculosis; BCG vaccination
The Life and Care of Patients With Colorectal Cancer Before Age 65 and Their Kindred
Condition: Colorectal Cancer
MeSH terms: Colorectal Neoplasms
Study type: Observational

Summary: 
      In a context the respect of the autonomy of the patients is important, it is necessary to pay
      a sustained attention to the experiences and the lived experience as well of the patients
      suffering or in remission of cancer as of their family. It is therefore, for the family, to
      deepen the synthesis carried out by the Societal Cancer Observatory which is a societal
      observatory of cancer
    


Intervention name(s): biographical interviews
Intervention type(s): Other
Intervention description(s): A sociologist trained in the sociology of cancer, to enable participants to talk about their experiences and clearly distinguish the experiences of each individual
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Surviving patients over the age of 18 and diagnosed with invasive CRC, infiltrating
        adenocarcinoma of the colon or rectum irrespective of the stage before 65 years old will be
        selected in the Poitou-Charentes cancer registry 2 to 5 years after announcement of the
        diagnosis.
The Comparison of Postoperative Pain After Lumbar Fusion Surgery in Intravenous Patient-controlled Analgesia Between Conventional Mode and Optimizing B.I Mode With 'PAINSTOP' Equipment
Condition: Back Pain; Fusion of Spine, Lumbar Region; Spinal Stenosis
MeSH terms: Spinal Stenosis; Pain, Postoperative
Study type: Interventional

Summary: 
      The postoperative pain of lumbar fusion surgery is very severe that it is necessary to use
      additional analgesics as well as a patient controlled analgesia (PCA). The most common pain
      control method of this surgery is the intravenous (IV) PCA. but, if it is relatively
      insufficient amount of narcotic analgesics ,in the case of IV PCA, may be failed to reduce
      the pain intensity effectively. Consequently, it may result in the a lot of rescue analgesics
      requirement, which leads to the adverse effects in patients who are very sensitive to
      narcotic analgesics. In addition, the patient's satisfaction to the PCA may be low compared
      with that of expected. For the recently released PCA instrument 'PAINSTOP', the investigators
      can specify the mode setting including total volume, flow rate (basal rate) per hour, bolus
      dose, and lock out time (LOT). Furthermore, this device can be set to optimize basal infusion
      (B.I), which is a new mode, so that the administered rate and amount of drug can be increased
      or decreased according to the patient's use of bolus button. Therefore, this PCA device can
      be implemented to the conventional mode, and added the function of automatically controlling
      the basal rate and administered amount of drug according to the use demand of the patient.
      However, since there are few studies related to this new mode of PCA, more research is needed
      in patients with postoperative pain.
    


Intervention name(s): Optimizing basal infusion (B.I); Conventional PCA mode
Intervention type(s): Other; Other
Intervention description(s): In the intervention group, the optimizing B.I PCA mode will be setted. This mode is setted that the amount of administered drug per hour will be increased by 0.3 ml by pressing bolus button (The interval: ~ 8 hr: 2 - 4 ml, 8-24 hr: 1 - 3 ml, 24 hours ~ : 0.5 - 2.5 ml). Conversely, if the bolus button is not used for 90 minutes, the administered amount of drug per hour is setted to be reduced by 0.1 ml, and the maximum (or minimum) allowable flow rate is 4 ml (or 0.5 ml).; Mode setting; total volume: 150 ml, flow rate: 2 ml, bolus volume: 0.5 ml, and LOT: 10 minutes
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Other
Keywords: lumbar fusion surgery; Patient Controlled Analgesia; Optimizing Basal Infusion Mode
INDIGO-2: The Effect of High Water Intake on Glucose Regulation in Low-drinkers
Condition: Dehydration; Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus, Type 2; Dehydration
Study type: Interventional

Summary: 
      Previous studies have indicated increased vasopressin due to hypertonic saline infusion
      impairs glucose regulation. The current study will examine the effect of low water intake on
      glucose regulation. No currently published study has investigated the acute effect of low
      water intake on glucose regulation using continuous glucose monitoring over the course of a
      full day. The aim of the study is to observe the effect of low water intake on glucose
      regulation in low drinkers. The study will study the glycemic responses to standardized meals
      in adults during an 11-hour period in two conditions: a) high water intake and b) low water
      intake. It is hypothesized that the area under the glucose curve will be greater in the low
      water intake trial as compared to the high water intake trial
    


Intervention name(s): Water Intake
Intervention type(s): Other
Intervention description(s): Increased water intake during the 11 h protocol
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: dehydration; vasopressin; copeptin
Comparison of Effects Between Conventional Dose and High Dose Escitalopram on Clinical Improvement in Patients With Obsessive-compulsive Disorder
Condition: Obsessive Compulsive Disorder
MeSH terms: Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Study type: Interventional
Phase: Phase 4

Summary: 
      OBJECTIVE: The objective of this study is to compare the effect and safety of conventional
      dose (20mg) and high dose (40mg) of escitalopram in patients with obsessive-compulsive
      disorder (OCD).

      OVERVIEW OF STUDY DESIGN: Prospective, Randomized, Active-controlled, Double-blind,
      Multi-center, Clinical Trials STUDY POPULATION: Patients with OCD EFFICACY EVALUATIONS:
      Y-BOCS (D-YBOCS), HAM-D, HAM-A, CGI-S & -I, GAF, OCI-R SAFETY EVALUATION: Adverse Events /
      Serious Adverse Events, UKU
    


Intervention name(s): escitalopram
Intervention type(s): Drug
Intervention description(s): escitalopram high dose group (40mg) escitalopram conventional dose group (20mg)
Intervention MeSH terms: Escitalopram
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment