bioihbjkbjnl/mcl2 huggingface dataset:
Bioavailability of Flavonoids and Phenolic Acids From Cranberry Juice Cocktail in Healthy Older Adults
Condition: Healthy
Study type: Interventional

Summary: 
      This is a single-dose, pharmacokinetic study investigating the bioavailability of flavonoids
      and phenolic acids from cranberry juice cocktail and their breakdown products (in vivo
      metabolites) in healthy, older adults. Our hypothesis is that the compounds will be poorly
      but rapidly absorbed from the intestines and found in plasma and urine in extensively
      metabolized forms. These compounds will be rapidly cleared from plasma. Substantial amounts
      of unabsorbed compounds will be found in the stools.
    

Detailed description: 
      Cranberries are a particularly rich source of phenolic acids and polyphenols, particularly
      flavonoids. Among the 20 most commonly consumed fruits in the American diet, cranberries have
      the highest total phenol content. Health benefits attributed to cranberries include the
      prevention of urinary tract infections and stomach ulcers as well as improved oral hygiene.
      These benefits appear to be due principally to the ability of cranberries to interfere with
      the adhesion of some bacteria to select cell types and surfaces.

      Cranberries and cranberry constituents, including several phenolic and polyphenolic
      compounds, have also been shown to possess antibacterial, antiviral, anti-mutagenic,
      anti-carcinogenic, anti-tumorigenic, anti-angiogenic, and antioxidant activities. Most of
      this evidence is derived from in vitro studies and animal models. The limited number of human
      studies available indicate these phytochemicals are bioavailable and bioactive. However, more
      information is required on the bioavailability and metabolism of cranberry polyphenols, as
      well as on the relationship between cranberry dose and duration of use, to better understand
      their impact on risk factors for chronic diseases.
    

Intervention name(s): Low calorie, sugar-free cranberry juice cocktail (54% juice)
Intervention type(s): Other
Intervention description(s): Single-dose, 24 hour pharmacokinetic trial of 8 oz dose administered orally.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: cranberry; flavonoid; phenolic acid; phytochemical; bioavailability
Carbon Monoxide-Saturated Medium for Islet Isolation
Condition: Chronic Pancreatitis
MeSH terms: Pancreatitis; Pancreatitis, Chronic
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The goal of this study is to determine whether harvesting islets using carbon monoxide
      (CO)-saturated mediums can protect islet cell from death after autologous islet
      transplantation in patients with chronic pancreatitis.
    

Detailed description: 
      Investigators plan to harvest human islets using carbon monoxide-saturated mediums. Survival
      and function of transplanted islets will be compared with islets harvested using regular
      mediums.
    

Intervention name(s): Carbon monoxide-bubbled mediums
Intervention type(s): Other
Intervention description(s): Islets will be harvested with carbon monoxide bubbled mediums
Intervention MeSH terms: Carbon Monoxide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Other
Effects of PS128 on Parkinsonian Symptoms
Condition: Parkinson Disease
MeSH terms: Parkinson Disease; Parkinsonian Disorders
Study type: Interventional

Summary: 
      The purpose of this study is to examine the short term effects (12 Weeks) of Lactobacillus
      plantarum PS128 (PS128) on Parkinson's disease (PD) symptoms.
    

Detailed description: 
      This study is designed to examine the extent to which L. plantarum PS128 can improve symptoms
      in PD patients. L. plantarum PS128 is a psychobiotic that regulates the level of dopamine in
      specific brain regions. Patients with PD will receive PS128 treatment for 12 weeks. Symptoms
      of PD will be clinically evaluated before and after the treatment, and the results will be
      compared.
    

Intervention name(s): Lactobacillus plantarum PS128
Intervention type(s): Dietary Supplement
Intervention description(s): daily ingestion of 60 billion colony forming unit (CFU) of Lactobacillus plantarum PS128 (30 billion CFU/capsule)
Other intervention name(s): PS128
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Efficacy of a Virtual Reality-Enhanced Gagne's Instructional Model
Condition: Acceptance Processes; Rejection, Psychology
Study type: Interventional

Summary: 
      Gagne's conditions of instructional learning theory, it presumed that several learning levels
      was exist that require different instruction types, and external and internal environments,
      commonly referred to as "conditions of learning".
    

Detailed description: 
      According to Robert Gagne's conditions of instructional learning theory, it presumed that
      several learning levels was exist that require different instruction types, and external and
      internal environments, commonly referred to as "conditions of learning", for every learning
      type. These internal conditions related to the learner's preexisting knowledge and external
      ones related to the instructions and teaching strategies provided by the instructor. The
      theory emphasizes the importance of both internal and external factors in creating a
      conducive learning environment that fosters effective learning outcomes According to this
      theorist, there are five primary knowledge categories, including verbal information,
      cognitive strategies, attitudes, and motor and intellectual skills.
    

Intervention name(s): Virtual Reality-Enhanced Gagne's Instructional Model
Intervention type(s): Behavioral
Intervention description(s): Virtual Reality-Enhanced Gagne's Instructional Model
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: geriatric rejection; willingness towards Gerontological Care
PTFE Covered Stents Versus Naked Stents in the TIPS (Transjugular Intra-hepatic Porto-systemic Shunt)
Condition: Cirrhotic Portal Hypertension
MeSH terms: Hypertension, Portal; Hypertension
Study type: Interventional

Summary: 
      Transjugular intrahepatic portosystemic shunts (TIPS) have been increasingly used for the
      treatment of complications of portal hypertension in patients with cirrhosis.

      The initial experiment of the TIPS was reported during the 1990s with stents of various
      brands, manufacture and sizes, but all "non covered", thus owing the pseudointimal
      hyperplasia growing inside the stent, which progressively decreases the diameter of the shunt
      and thus its efficacy. Since the beginning of the 2000s, appeared stents known as "covered"
      by polytetrafluoroethylene (PTFE) designed to reduce the obstruction rate and thus the
      frequency shunt revisions. However, these stents are, on average, 2.5 times more expensive
      than the non covered stents and the cost-effectiveness ratio of the TIPS according to the
      type of stents used has not been assessed.

      The aim of this multicentric and randomized study is to assess the cost-effectiveness ratio
      of these 2 principles of TIPS, the one using stents covered by PTFE, relatively expensive but
      seldom becoming obstructed, and the other using non covered stents, less expensive than PTFE
      but requiring regular gestures of redilatation.

      Population concerned: Patients with a cirrhotic portal hypertension responsible for:

        -  recurrent variceal bleeding

        -  refractory ascite (or hydrothorax)
    


Intervention name(s): Naked Stents: Wallstent® (Boston Scientific), Luminexx® (Bard), Zilver® (Cook), Palmaz Genesis® and Smart Control® (Cordis); PTFE Covered Stents: Fluency® (Bard), Advanta V12® (Atrium) and Viatorr® (Gore); Transjugular intrahepatic portosystemic shunt (TIPS)
Intervention type(s): Device; Device; Procedure
Intervention description(s): Vascular Stents; Vascular Stents; Transjugular intrahepatic portosystemic shunt (TIPS)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Cirrhosis, STIC TIPS, Portal Hypertension, Transjugular Intrahepatic Portosystemic Shunt , Stents, PTFE; cirrhotic HTP
BOSCOT : A Randomised Controlled Trial of Cognitive Behavioural Therapy in Borderline Personality Disorder
Condition: Borderline Personality Disorder
MeSH terms: Personality Disorders; Borderline Personality Disorder
Study type: Interventional
Phase: Phase 3

Summary: 
      The aim of the study was to investigate if the addition of cognitive behavioural therapy to
      treatment as usual (CBT plus TAU) in participants with borderline personality disorder would
      decrease the number of participants with emergency (i.e. unplanned) psychiatric or accident
      and emergency room contact or episode of deliberate self-harm over twelve months treatment
      and twelve months follow-up, compared with treatment as usual (TAU). The study also examined
      whether CBT plus TAU would lead to superior improvement in quality of life, social, cognitive
      and mental health functioning than TAU alone.
    

Detailed description: 
      The trial is being carried out in three centres in the UK: Glasgow, London and Ayrshire
      (Ayrshire and Arran). Treatment as Usual (TAU) therefore reflected what is likely to be
      available in the UK.

      Patients were eligible if they satisfied the following criteria:

        1. Aged between 18 and 65.

        2. Met criteria for at least 5 items of the borderline personality disorder using the
           Structured Clinical Interview for DSM IV Axis II Personality Disorders (SCID -II)(First,
           Gibbon, Spitzer, Williams & Benjamin, 1997)

        3. Had received either in-patient psychiatric services or an assessment at Accident and
           Emergency services or an episode of deliberate self-harm (either suicidal act or
           self-mutilation) in the previous 12 months.

        4. Able to give informed consent.

      Exclusion criteria were as follows:

        1. Currently receiving in-patient treatment for a mental state disorder,

        2. Currently receiving a systematic psychological therapy or specialist service,
           particularly psychodynamic psychotherapy,

        3. Insufficient knowledge of English to enable them to be assessed adequately and to
           understand the treatment approach,

        4. Temporarily resident in the area,

        5. The existence of an organic illness, mental impairment, alcohol or drug dependence,
           schizophrenia or bipolar affective disorder, as assessed by SCID I,/P (W/ Psychotic
           Screen)(version 2) (First, Spitzer, Gibbon, Williams, 1996).
    

Intervention name(s): Cognitive Behavioural Therapy; Treatment as usual
Intervention type(s): Behavioral; Other
Intervention description(s): Standard National Health Service treatment as usual for borderline personality disorder
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: randomised controlled trial; borderline personality disorder; cognitive behavioural therapy; treatment as usual
Orientation Agnosia: Clinical and Anatomical Study
Condition: Cerebrovascular Disorders; Brain Lesions
MeSH terms: Cerebrovascular Disorders; Agnosia
Study type: Interventional

Summary: 
      The area of the brain responsible of visuospatial processing data and more specifically the
      orientation of an object or image is located in parietal lobe, especially on the right side.
      A dysfunction of this region would result in a disorder of recognition of the orientation of
      objects and images that the investigators call orientation agnosia. Several isolated cases
      are reported in the literature but to the investigators knowledge deficit has never been
      systematically searched, or put into perspective compared to other neuropsychological
      deficits. Moreover, the precise location of the lesion responsible for such a disorder
      remains uncertain. The objectives of this study are (1) detect the existence of orientation
      agnosia in case of right parietal lesion, and (2) to improve the understanding of such a
      deficit allowing better management of this disorder.
    

Detailed description: 
      Idem
    

Intervention name(s): Neuropsychological testing; MRI
Intervention type(s): Behavioral; Other
Intervention description(s): Experimental test about orientation agnosia and standard neuropsychological tests.; Cerebral MRI
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Screening
Keywords: stroke; parietal lesions
Soy Fiber Improves Weight Loss and Lipid Profile
Condition: Obesity; Overweight; Weight Loss
MeSH terms: Overweight; Body Weight; Weight Loss
Study type: Interventional

Summary: 
      The aim of this study is to examine the effects of soy fiber on body weight, body composition
      and blood lipids in overweight and obese participants.
    

Detailed description: 
      Thirty nine overweight and obese college adults (19-39 y of age) were randomly assigned to
      consume control biscuits or biscuits supplemented with soy fiber for 12 wk (approximately
      100g/d). Information on body weight, body mass index, waist/hip circumference, blood pressure
      as well as measures of lipoprotein, glucose concentrations, and HbA1c was obtained at
      baseline, 8 and 12 wk after intervention. Body composition was also assessed at baseline and
      wk 12, respectively.
    

Intervention name(s): biscuits supplemented with soy fiber
Intervention type(s): Dietary Supplement
Intervention description(s): Thirty nine overweight and obese college adults (19-39 y of age) were randomly assigned to consume control biscuits or biscuits supplemented with soy fiber for 12 wk (approximately 100g/d).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Safety Study of Live Attenuated Influenza Vaccine, CodaVax, Delivered Via Intranasal Spray
Condition: Influenza
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 1

Summary: 
      This study is being conducted to assess the safety, tolerability, and immunogenicity of the
      live-attenuated CodaVax-H1N1 influenza vaccine as compared to normal saline placebo both
      administered via intranasal spray to healthy adults.
    


Intervention name(s): CodaVax-H1N1 influenza vaccine; Normal Saline Placebo
Intervention type(s): Biological; Biological
Intervention description(s): CodaVax-H1N1, a live attenuated vaccine (LAIV) strain based on the A/California/07/2009 (H1N1) influenza virus, administered once intranasally via a sprayer at a dose of 8 x10^5 plaque forming units (PFU).; Saline (0.9%) administered intranasally via sprayer
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Prevention
Keywords: live-attenuated vaccine; influenza vaccine
Effect of Ketamine Added to Intravenous Patient-controlled Analgesia on Postoperative Pain, Nausea and Vomiting in Patients Undergoing Lumbar Spinal Surgery
Condition: Postoperative Nausea and Vomiting
MeSH terms: Pain, Postoperative; Nausea; Vomiting; Postoperative Nausea and Vomiting
Study type: Interventional
Phase: Phase 4

Summary: 
      Ketamine added to intravenous patient-controlled analgesia may be effective on prevention of
      postoperative nausea and vomiting by reducing opioid requirement after surgery.
    


Intervention name(s): Ketamine; Saline
Intervention type(s): Drug; Drug
Intervention description(s): ketamine 3 mg/kg mixed to intravenous patient controlled analgesia device (fentanyl 20 mcg/kg. total volume 180 ml, basal infusion 2 ml, bolus 2ml, lock-out 15 min); equal volume of normal saline mixed to intravenous patient controlled analgesia device
Intervention MeSH terms: Ketamine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
A Single Ascending Dose Study of Daclatasvir (BMS-790052) in Hepatitis C Virus Infected Subjects
Condition: Chronic Hepatitis C
MeSH terms: Hepatitis A; Hepatitis C; Hepatitis C, Chronic; Hepatitis
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The primary purpose of this study is to evaluate the safety profile and tolerability of
      single oral doses of daclatasvir in subjects with chronic hepatitis C infection
    


Intervention name(s): Daclatasvir; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Oral Solution, Oral, Single Dose; Oral Solution, Oral, Single Dose
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Effectiveness of Basic Body Awareness Therapy (BBAT) in Patients Suffering From Fibromyalgia
Condition: Fibromyalgia
MeSH terms: Fibromyalgia; Myofascial Pain Syndromes
Study type: Interventional

Summary: 
      A randomized trial of Basic Body Awareness Therapy (BBAT) is applied in fibromyalgia patients
      as compared with a control intervention consisting of treatment as an usual. Sessions of BBAT
      lasted 90 minutes each and took place twice a week for 5 weeks. The primary end point is a
      change in the Visual Analog Scale score and Body Awareness Rating Scale and the secondary end
      points include Hospital Anxiety Depression, State Trait Anxiety Inventory, Beck Depression
      Inventory and Short Form 36. All assessments will be repeated at post treatment, 12 weeks and
      24 weeks
    

Detailed description: 
      This work is a clinical trial of randomised and controlled groups. The hypothesis of study is
      that Basic Body Awareness Therapy applied in patients with fibromyalgia improves, more than
      usual treatment, the pain, normalization of postural pattern and movement, improve in
      psychologic state and improve of quality life.

      The study population will be selected followed the inclusion criteria of fibromyalgia, and
      will be selected in area of primary health center, the patients will be divided in 2 groups,
      control group and treatment group. The groups will be examined at the begin, at 1 month of
      the begin of treatment, in 3 months, 6 months and one year to evaluated the outcomes in long
      time.

      The dependence measurements will be Visual Analog Scale, Basic Body Awareness Rating Scale
      (BARS), SF-36, STAI A/R, BDI-II. The independence measurements will be demographic items:
      sex, age, country, level of studies, social status,..
    

Intervention name(s): Basic Body Awareness Therapy
Intervention type(s): Other
Intervention description(s): Basic body awareness therapy is a health oriented and person-centred approach with focus on the patient's resources. This is a method in physiotherapy, where we search to promote movement quality in daily life through self-exploration and self-experience.BBAT conceives the person from the biomechanical, physiological, bio-psycho-social and existential aspects, using the movement quality as a witness of the link in between all these perspectives.It can be done individually or in groups, through different daily life movements: lying, sitting, standing, walking, pair movements, use of voice and massages. BBAT has validated and reliable assesment tools, as BARS and BAS-I
Other intervention name(s): BBAT (acronym)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: body awareness therapy; physical therapy; movement therapy
Effect of Acetazolamide on Visuo-motor Learning in Lowlanders Older Than 40 Years at Altitude
Condition: Altitude Hypoxia
MeSH terms: Altitude Sickness; Hypoxia
Study type: Interventional
Phase: Phase 4

Summary: 
      Randomized, placebo controlled trial evaluating the effect of acetazolamide on visuo-motor
      learning performance in lowlanders older than 40 years travelling from 760 m to 3'100 m.
    

Detailed description: 
      This is a randomized, placebo-controlled, double-blind parallel trial evaluating the effect
      of acetazolamide intake on visuo-motor learning performance in lowlanders older than 40 years
      travelling to altitude. Participants living in the Bishkek area, Kyrgyzstan (760m), will be
      transferred by car within 4h to the Tuja Ashu high altitude clinic (3'100 m), and stay there
      for 2 days. Acetazolamide 375mg/day (or placebo), will be administered before departure at
      760 m and during the stay at altitude. Outcomes will be assessed during the stay at 3'100 m.

      An interim analysis will be carried out when 80 participants will have completed the study or
      after the first year. The Peto's method will be used and the trial will be stopped when
      pre-specified futility boundaries were crossed.
    

Intervention name(s): ACETAZOLAMIDE oral capsule; Placebo oral capsule
Intervention type(s): Drug; Drug
Intervention description(s): Administration of 1x125mg acetazolamide in the morning, 2x125mg in the evening, starting 24 hours before departure to 3'100m; Administration of equally looking placebo capsules in the morning and evening, starting 24 hours before departure to 3'100m
Intervention MeSH terms: Acetazolamide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: healthy participants older than 40 years; cognition; visuo-motor learning performance; prevention; acetazolamide