Timing of Voluntary Movement in Patients With Schizophrenia
Condition: Schizophrenia
MeSH terms: Schizophrenia
Study type: Observational

Summary: 
      This study will examine and compare how the brain controls the timing of movement in healthy
      volunteers and in people with schizophrenia. Previous experiments have shown that when people
      are asked to look at a clock and report the time they first decide to make a movement, they
      report times later than the first brain waves associated with movement appear. When they are
      asked to report the time they first initiate the movement, they report times before the
      muscles actually begin to move. The study may help determine how the sense of willing and
      initiating an action is altered in schizophrenic patients, and how people may feel more or
      less "in control" of their movements.

      Normal volunteers and patients with schizophrenia between 18 and 65 years of age may be
      eligible for this study. Control subjects must not have any neurological or psychological
      disorders, and schizophrenia patients must not have any other neurological disorders.

      All participants will have a medical history, physical examination, and a test to determine
      their level of attention. Schizophrenia patients will be interviewed about their symptoms and
      complete psychiatric rating scales. In addition, all participants will undergo the following
      procedures:

      Electric shock

      Participants look at a clock on a computer screen whose hands revolves around the clock fast.
      While they look at the clock, they are given small, non-painful electric shocks and are asked
      to say when they receive the shocks, according to the clock. The shocks are repeated 40
      times.

      Arm movement

      Participants are asked to lift their arm up off a table repeatedly, at random times, while
      they look at the computer clock. This exercise is repeated a total of 80 times. Of these 80
      times, participants are asked 10 times in a row to say the time they first had the desire to
      move their arm, and then 10 times in a row the time they first felt that they were moving
      their arm.

      Electroencephalography (EEG) and Electromyography (EMG)

      Participants undergo EEG and EMG during the electric shock and arm movement experiments to
      measure electrical activity of the brain (EEG) and of the muscles (EMG). For EEG, electrodes
      (small metal discs) are placed on the scalp with a cap, paste, or glue-like substance and the
      brain waves are recorded. For EMG, electrodes are taped to the skin over the muscle.
    

Detailed description: 
      Objectives

      The purpose of this study is to determine how the subjective sense of willing and initiating
      an action is altered in schizophrenic patients. One proposed explanation for characteristic
      symptoms of schizophrenia ("passivity phenomena") is a defect in the forward model of
      movement that the brain receives as the motor signal is generated. We propose to examine this
      forward model using Libet's paradigm, in which normal subjects gave evidence for a forward
      model in their anticipatory reports of initiation of movement. We intend to determine the
      times associated with willing (W), initiating (M), and
      electroencephalographic/electromyographic (EEG/EMG) measures of movement.

      Study Population

      We intend to study adult patients with a Diagnostic and Statistical Manual of Mental
      Disorders diagnosis of schizophrenia. These patients provide a unique population for this
      study because they often do not have the sense that they direct their own movement or author
      their own thoughts (passivity phenomena). Studies have shown that schizophrenics have
      movement-related cortical potentials on EEG, but it is not known when the subjective sense of
      initiating movement occurs for these patients. As the order of mental events in time has been
      shown to contribute to the sense of agency, it is important to know how the timing of
      voluntary movement is altered in schizophrenia.

      Design

      We will ask patients to look at a fast-rotating clock on a computer screen and note when
      their movements were willed, instigated by an external agent if they have such delusions, and
      were initiated. Patients will also report the time of a somatosensory stimulus. Surface EMG
      will determine the time of actual movement, and EEG will record brain potentials associated
      with movement. Eligible patients with schizophrenia and passivity phenomena will be recruited
      from the Clinical Brain Disorders Branch, NIMH.

      Outcome Measures

      The primary outcome measure of this study is the absence of time W in some schizophrenics,
      the latency of W in other schizophrenics compared to normal subjects, and the latency of M in
      schizophrenics compared to normals. Any effect of medication status or symptoms on
      performance in the study will be considered exploratory data.
    

Keywords: Bereitschafts Potential; Timing of Volition; Somatic Passivity Phenomenon; Conscious Will; Libet's Clock; Schizophrenia; Healthy Volunteer; HV