Impact of Scaling up Mass Testing, Treatment and Tracking on Malaria Prevalence Among Children
Condition: Malaria; Malaria, Asymptomatic Parasitaemia
MeSH terms: Malaria; Parasitemia
Study type: Interventional

Summary: 
      Malaria poses a serious burden in sub-Sahara Africa. Efforts are ongoing to scale up
      interventions that work. These include the use of Long Lasting Insecticidal Nets (LLIN),
      Intermittent Preventive Treatment in children (IPTc), and test, treat and track (TTT). There
      is the need, however, for mass testing, treatment and tracking (MTTT) of the whole population
      to reduce the parasite load before implementing the aforementioned interventions. Though,
      Seasonal Malaria Chemoprophylaxis (SMC) is adopted for selected localities in Ghana, the
      impact of such interventions could be enhanced, if associated with MTTT in order to reduce
      the parasite load at baseline. MTTT of children in Ghana has demonstrated a parasite load
      reduction from 25% to 1%. However, unanswered questions include - could this be scaled up?
      What proportion of the community could be covered over a given time? What would it take to
      accomplish large scale MTTT? In designing interventions that aim at reducing the burden of
      malaria in children under five, for example, MTTT has largely been left out. Adults who are
      not often targeted by such interventions remain reservoirs that fuel transmission. This study
      explores the scale-up of interventions that work using existing community volunteer teams to
      lower cost. These volunteers will play a surveillance role by conducting home-based
      management of malaria. To avoid challenges posed by stockouts, short message service (SMS)
      will be used to monitor the level of stocks for malaria medicine and Rapid Diagnostic Tests
      (RDTs). It is hypothesized that there are more asymptomatic malaria cases (those who carry
      the parasite but are not ill) than symptomatic cases reported by hospital records in the
      Pakro sub district and that, carrying out MTTT in combination with home-based management of
      malaria in specific communities could greatly reduce the burden. Through this study, the
      bottlenecks that hinder scaling-up of MTTT will be documented in order to facilitate the
      process.
    

Detailed description: 
      Introduction/Rationale

      The World Health Organization (WHO) in 2010 reported that malaria was endemic in 96 countries
      reflecting an improvement of the situation of 2005 where it was endemic in 106 countries.
      Malaria morbidity and mortality remain a serious problem in sub Saharan Africa especially in
      areas with holo-endemic transmission. Over the last decade, the number of recorded malaria
      cases has steadily dropped from 247 million cases with 881,000 deaths reported in 2006 to 198
      million with 584,000 deaths in 2013. This has largely been due to the introduction of ACTs
      following the resistance witnessed against chloroquine as well as an increase in the number
      of control measures such as the use of insecticide treated nets, long lasting insecticidal
      nets (LLIN), vectors surveillance and intermittent preventive treatment in pregnancy (IPTp)
      and implementation of the WHO policy on test, treat and track. Despite the reported decrease,
      most of the endemic countries across sub Saharan Africa still bear the greatest burden of the
      disease where 90% of the deaths are reported with more than 75% of the mortalities in
      children under five.

      Ghana National Malaria Control Programme (GNMCP) reports reveal that in 2006 malaria
      accounted for 37.5% of all out patient consultations, 36.0% of all hospital admissions, and
      about 33.4% of all mortality in children under age five years. Following the recommendation
      of the WHO, Ghana changed it malaria treatment guidelines adopting artesunate and amodiaquine
      as first line for the treatment of uncomplicated malaria to replace chloroquine. By 2012,
      hospital statistics across the country revealed that malaria was responsible for 38.93% of
      the outpatient consultations and 38.80% of admissions. Of those admitted for malaria, 63%
      were children under 5 years of age while pregnant women constituted 16.8%. Furthermore,
      According to the Ghana Health Service (GHS) report of 2012, malaria accounted for 22.4%
      deaths in children less than five years of age and 3.4% deaths among pregnant women. Over the
      last decade, studies in Ghana have demonstrated that artesunate and amodiaquine combinations
      are not only efficacious in clearing the malaria parasites from patients but if used for
      intermittent preventive treatment programmes for children under five could effectively clear
      more than 90% of the parasite in this age group.

      Different studies have demonstrated very high level of asymptomatic malaria parasitaemia in
      both less than 5 years old and school age children. In 2009, Ahorlu et al, reported a
      parasite prevalence of 25% in less than five year old children in the Shime sub district in
      the coast of Ghana. In the same light, reported a malaria parasitaemia prevalence of 58.6%
      among school children in the Ejusu Juaben District, while reported a 41.5% prevalence of
      malaria parasitaemia in Ghanaian school children in the Ashainti and Upper West regions of
      the country. A related study in the Dodowa area demonstrated that children with high levels
      of asymptomatic parasitaemia have a higher risk of coming down with clinical malaria.

      The link between one parasite carrier or infected individual and the next relies on the
      mosquito picking up the parasite during a blood meal. This means that even if all patients
      with malaria are treated of the disease, those individuals who carry the parasite and are not
      ill could redistribute it to the healthy population with the help of the mosquito and
      therefore, the cycle simply continues. The high incidence of asymptomatic parasitaemia serves
      as a reservoir that fuels the malaria transmission cycle. If the parasite is cleared from the
      blood of asymptomatic individuals as well as the sick patients with the very efficacious
      Artemisinin-based Combination Therapy (ACT), then, even the most effective mosquito vector
      would have nothing to transmit following a blood meal.

      Continuous exposure to the malaria parasite has led to the development of immunity,
      especially in adults in endemic areas. This is often a slow process as it depends on repeated
      exposure to the parasites. This explains why children carry the greatest burden of the
      disease. As they grow beyond age 5 years, the prevalence of malaria or parasitaemia in this
      group begins to decrease following the development of immunity to the parasite. Age,
      therefore, has a great role to play when looking at the dynamics of the malaria burden. A
      study of trends in malaria admission in a Health Centre in Cameroon has demonstrated that the
      variation in the prevalence of malaria effectively reflected a variation in the prevalence in
      children age one to less than 15 years. In endemic areas, children have been reported to
      harbour relatively high levels of the parasite without coming down with the disease, and the
      population is continuously exposed to the infected mosquitoes. That is, the already
      parasitised individuals can be re-infected either with the same parasite, thus, increasing
      the parasite load or other parasite species leading to a co-infection in areas with more than
      one species of Plasmodium. On the other hand, the uninfected mosquito is initially harmless
      even if it bites. However, it becomes infective when infected by a parasitised individual who
      could either be febrile or asymptomatic. Therefore, while enormous effort is being made to
      prevent man-vector contact through the use of treated nets, the benefits from using these
      nets could be amplified if such programmes integrate mass parasite clearance as part of their
      agenda. That is mass testing, treatment and tracking should precedes the mass distribution of
      LLIN in a given area or intermittent preventive treatment in children.

      There has been concerted effort in the past decade to evaluate the possible effects of
      massive parasite clearance using intermittent preventive treatment in less than five year old
      children in different part of Africa with interesting results. Most studies however, focused
      on the clinical incidence of the disease as outcome measure which has been observed to reduce
      with a range of between 20-80% depending on a number of factors. In a longitudinal study in a
      Coastal village in Ghana, Ahorlu et al, demonstrated that associating IPTc with home based
      management of malaria by community workers could clear more than 90% of the parasite pool in
      the community. This intervention reduced malaria parasitaemia prevalence from 25% at baseline
      to 1% at evaluation using artesunate and amodiaquine. This low level of parasitaemia in the
      study population was found to persisted over a period of two years. Though, this intervention
      had targeted only under 5 years children, it revealed the potential role intermittent
      preventive treatment of the population could play in reducing malaria prevalence and
      consequently paving the way for malaria elimination. Given that old members of the household
      are likely to have some immunity to the malaria parasite, they however, represent the
      reservoir that refuels the parasite pool whenever it is reduced by IPTc. Therefore, for
      sustainability of such implementation intervention, intermittent preventive treatment would
      be of greater benefit if all the members of each given household are targeted for mass
      testing, treatment and tracking at baseline and consequent prompt home-based treatment for
      suspected cases. Bearing in mind that huge resources are required for IPT of whole
      communities, it has been suggested that mass screening of whole communities be carried out
      once a year while IPTc be conducted regularly in combination with the home based management.
      This could further enhance the efforts.

      Implementation of rapid scale-up preventive interventions in the past decade has led to a
      reasonable decrease in the burden of the malaria (WHO 2011) especially given the introduction
      of the WHO policy of test, treat and track (T3) (WHO 2012). The challenges involved with
      translating research scenarios into implementation are enormous. It is important to
      understand the bottlenecks that hinder this process in order to undertake mass testing,
      treatment and tracking in a large scale using existing health systems, especially in an era
      when global funding for health services is slowing down.

      Any effective control strategy that interrupts the link between man, the parasite and the
      vector could seriously reduce the transmission of malaria. In this light, interventions
      focused on clearing of the parasites in asymptomatic individuals in combination with
      intensive use of other control measures could pave the way for pre-elimination of the
      parasite in endemic communities. This study aims at reducing the asymptomatic parasitaemia in
      the Pakro sub district of the Eastern Region of Ghana by conducting MTTT for malaria
      parasitaemia among household members of age 2 months and older and carrying out targeted
      treatment of all cases with confirmed asymptomatic parasitaemia or clinical malaria. These
      interventions intend to follow up enrolled participants over a period of two years. Hospital
      records will also be studied to document trends in malaria admissions and occurrence of other
      diseases in the area before and after the interventions.

      Rationale Malaria continues to poses a serious burden to the local populations in sub-Sahara
      Africa. Several efforts have been made to scale up interventions that work such as preventing
      man-vector contact, intermittent preventive therapy, seasonal malaria chemoprophylaxis as
      well as TTT for febrile patients. However, much still has to be done to target the mass
      testing, treatment and tracking of whole populations in order to reduce the parasite load
      before implementing the above mentioned interventions. Though SMC is adopted for selected
      localities in Ghana, MTTT could be used to drastically bring down the parasite load in a
      given population before the implementation of interventions such as SMC. Elsewhere, it has
      been demonstrated that incorporating the antimalarials in vaccination programmes could delay
      the first malaria episode in children under five. Furthermore, MTTT of children in a
      community in Ghana has been reported to reduce the parasite load in a given community from
      25% to 1%. The questions that remain are - could this be scaled up? What proportion of the
      community could be covered over a given time? What would it take to accomplish MTTT in large
      scale? In designing interventions that aim at reducing the burden of malaria in children
      under five, for example, MTTT could be used to clear parasites from the general population
      before the interventions are implemented. This is because the adults who are not often
      included in the interventions that target children under 5 years old tend to act as
      reservoirs that fuel the transmission. To solve the problem of personnel who are limited at
      the level of the health service and coverage, this study will be making use of the existing
      network of community nurses/volunteer teams that are used during vaccination programmes.
      These volunteers, who recite in the communities, will carry out the interventions in the
      given communities and conduct the home-based management of malaria between interventions
      thereby increasing surveillance and reducing cost. Furthermore, to solve the problem of
      stock-outs and quality of the RDTs and antimalarials, the investigators will make use of SMS
      through mobile phones and a team will conduct monthly monitoring and evaluation of the field
      activities of the volunteers as well as refill the medicine and RDTs. The volunteers will be
      trained based on the 2014 guidelines for managing uncomplicated malaria.

      The investigators hypothesize that in the Pakro sub district, there are more asymptomatic
      malaria cases than the symptomatic cases reported by hospital records and that if the
      investigators carry out MTTT in combination with home-based management of malaria in specific
      communities over two years, a large proportion of the parasite reservoir will be cleared and
      consequently open up possibilities for pre-elimination of malaria in the area. It is also
      intended that the bottlenecks involved in scaling up mass testing, treatment and tracking
      will be documented in order to facilitate the process.

      Main objective The main objective of this study is to explore the impact of scaling up mass
      testing, treatment and tracking on malaria prevalence among children under fifteen years of
      age in the Pakro sub district of Ghana.

      Specific Objectives

        1. To evaluate the effect of scaling up targeted MTTT/home-based treatment on malaria
           parasitaemia and hospital consultations and admissions.

        2. To determine the prevalence of asymptomatic parasitaemia among afebrile participants.

        3. To reduce the burden of malaria in the participating communities.

        4. To document challenges which hinder the scale up of mass testing, treatment and tracking
           of malaria in Ghana.

        5. To conduct a cost benefit analysis of the intervention in the area.

      Methodology

      Study Area Pakro is one of five sub-districts in the Akwapim south district health
      directorate (DHD) in the Eastern region of Ghana. The Akwapim south district lies within the
      semi-equatorial climatic region, and experiences two rainfall seasons in a year, with an
      average rainfall of 125cm to 200cm. The first rainy season begins from May to June with the
      heaviest rainfall in June, whilst the second rainy season begins from September to October.
      According to the Ghana Statistical Service (GSS), the average household size in the Akwapim
      South district is estimated to be 4.0 whilst the average number of households per house or
      compound is estimated to be 1.6. The Pakro sub-district has an estimated population of 7,889,
      and is bounded to the east by Akwapim North district; to the north by Ayensuano district; and
      to the west by Nsawam Adoagyiri Municipality. The sub-district is made up of 22 communities,
      and has 3 health care facilities (1 Health Centre and 2 Community-Based Health Planning
      Service (CHPS) compounds).Due to limited resources, only seven communities will be selected
      for this study. This include Abeasi Newsite, Fante Town, Zongo (Adjenase/Kweitey),
      Piem/odumsisi, Adesa Latebibio, Sacchi/Tabankro and Odum Tokuro. These are communities with a
      relatively high population density. The Pakro Health Centre is one of thirty sentinel sites
      monitoring malaria prevalence in the country coordinated by the Noguchi Memorial Institute
      for Medical Research (NMIMR). Malaria parasite positivity rate was estimated to be 45.7% in
      2014 (DHD, 2014). In the same year anaemia among pregnant women at 36 weeks of gestation was
      21%.

      Study participants

      Community entry activities to sensitise the chiefs and the general population will be
      conducted at the beginning of the study through meetings and durbars. Once the community
      leaders and the population have accepted the project, the household will be numbered and
      participants per household will be registered during a household census. All households will
      be given a unique identification code. Each individual within the household will be assigned
      a code that links them to a particular household and community. After obtaining consent from
      the household heads, the children will be enrolled but individual assent and consent will be
      obtained from the other adolescents and adults in the household. A cohort of 460 children age
      6 months to 15 years will be selected and enrolled into the longitudinal study which will
      consist of prevalence surveys undertaken before each MTTT. Caregivers of the children in the
      cohort will be enrolled for the community surveys using questionnaires. In this
      implementation research the entire population of the seven selected communities will be
      tested, treated and tracked. This is intended to clear the parasite pool in the community.

      Intermittent preventive treatment for the household members

      The research team together with Community assistants/volunteers will conduct house-to-house
      testing (using RDTs) of all children (from 6 months old) and adults residing in 7 selected
      communities for the presence of malaria parasites. For this study, the investigators will use
      the Ag P.f RDT which detects histidinie-rich proteins II antigens (HRP-2 Ag) specific to P.
      falciparum in human blood. The RDTs will be supplied by the Ghana Health service through the
      National malaria control programme which uses the services of WHO-FIND Lot Testing Programme
      for quality assurance. Thus, the investigators are using the same RDT that has been procured
      by the NMCP and are being used routinely in Ghana. To enable follow up studies in a case
      where treatment failure is reported, 200ul (two drops) of blood will be collected on filter
      paper. This will be used to determine immunological parameters such as antibody levels to
      specific antigens using Polymerase Chain Reaction (PCR) and Enzyme Linked Immunosorbent Assay
      (ELISA). RDT confirmed cases who are treated but presents persistent malaria related symptoms
      such as fever on day 7 will be tested using microscopy and to determine clinical failure.
      This study is not designed to test for parasite resistance to drug (drug efficacy) and the
      Project clinicians will advise on the next line of action. This could be taken up by a
      masters' student. However, the student will need to submit a different protocol to the ERC
      for approval). All participants confirmed (using RDTs) to be carrying the malaria parasite
      will be treated using ACTs following the Ghana National Malaria Treatment Guidelines and
      followed up on days 1, 2, 3 during treatment as DOTs (Directly observed therapy) and on day 7
      post treatment. The research team together with Community volunteers will be provided the
      treatment guidelines which specify the dosage for each treatment regimen. Participants who
      receive the treatment will be observed for five minutes to ensure that they retain the drug.
      Those who vomit within this period will have the treatment repeated.

      Follow-Up

      All treated cases will be followed up on days 1, 2, 3 during treatment and day 7
      post-treatment to ensure that the participants take the drugs on time as well as document and
      report all adverse effects.

      Questionnaire/Focus group Discussion

      The questionnaire will include questions about malaria treatment, prevention and control
      measures practiced by the household members. Occupants of the household will provide a blood
      sample for testing. Focus group discussions will be organized with community members and
      health care workers to increase the scope of information obtained.

      Timely treatment of suspected febrile malaria case in the community

      In other to render operational the home-based management component of the project, two
      volunteers will be selected from each community and trained on home-based management of
      malaria and be provided with the protocol, RDTs and ACTs. The interventions will be carried
      out quarterly (see the timetable). Between one MTTT intervention and the next trained
      community members will provide prompt home-based treatment for children and adults reporting
      signs and symptoms of malaria and confirmed to be carrying the parasite using RDTs. This will
      be done using national malaria management protocol. There will be monthly visits by the
      research team to supervise the community volunteers involved in home-based management to
      ensure that the protocol is being respected as well as replenish their stocks. There is a
      need to visit the health facilities that service the community to enable tracking and linking
      of medical records with study participants (a master student is required for this component).
      The investigators hypothesize that a reduction in parasite load in the community will
      consequently lead to a reduction in the number of hospital malaria related consultations and
      admissions paving the way for pre-elimination. This will be realised by comparing baseline
      hospital malaria admission data to evaluation data. MTTT has already been adopted by the NMCP
      as one of the control and elimination activities and the investigators are anticipating its
      being scaled-up in the country, and therefore documenting its implementation challenges will
      inform the decision in the future.

      Sample size

      This is an implementation study aimed at enrolling an entire population estimated at 4500
      participants from the 7 selected communities in Pakro sub district. This population was
      obtained following data from a head count in preparation for the mass distribution of LLIN in
      2016 - Abase newsite = 800, Fante town = 1450, Adjenase/Kwettey = 1102, Piem/Odumsisi = 323,
      Adesa/Nsuablaso = 480, Sacchi/Tabnkro = 201, Odumtokro = 129 (Pakro Health Centre records).
      However, since the target effect of this intervention is focused at the children age 6 months
      to 15 years, a community survey with a sample of 368 children will be needed to determine the
      malaria prevalence projected at 50% in the study population. This has been determined using
      the formula of Yamane where n = N/[1+N(е)2] (Israel 1992) considering a 95% confident level
      (CI) and ±5% precision. Assuming a loss to follow up of 10% and a non-response rate of 10%,
      the sample size is readjusted to 460 children calculated from (38/1-0.2) for the community
      survey. At evaluation the available sample size will be determined. This is the group for
      which questionnaires will be administered. Following a census of the households, children
      under 6 months to 15 years old will be randomly selected for the longitudinal cohort study,
      they will then be divided into the various age groups 6 months to 11 months, 1-4 years, 5 -10
      years and 11-15 years. For each age group the investigators will randomly select 116
      children.

      Data collection

      Following consent, blood will be drawn from a finger prick. All participants will be tested
      for the presence of malaria parasites using RDTs. Additionally, blood will be collected on
      filter paper to enable molecular characterization in case treatment failure is observed in a
      given patients as explained above. All samples will be stored at NMIMR. To test for anaemia
      (for children in the cohort study only), a portable automated Hemocue photometer will be used
      to determine the concentration of Haemoglobin. Anaemia in this study is defined as Hb levels
      less than 10g/dl. Children with severe anaemia (Hb less than 7g/dl) will be referred to the
      Pakro Health Centre for follow up. At evaluation, family members will be asked questions on
      how much they used to spend on malaria before the intervention and how much they have spent
      after. Malaria case management records before and after the intervention will be consulted,
      firstly to determine the change in prevalence and also for cost benefit analysis purposes.

      Data Management and Analysis

      Data Management will be conducted with the support of the Data management unit in the
      Department of Epidemiology of NMIMR. A database will be created to manage the data. Data will
      be entered into Epi-info and analysed using SPSS. The unit of enrollment will be the
      household. Malaria prevalence will be reported as, proportion of subjects identified during
      the study period with RDT confirmed clinical malaria with temperature ≥37.5 or asymptomatic
      parasitaemia and stratified by subject characteristics, including age, sex and community. A
      Chi square statistic will be used to compare prevalence across age and gender categories as
      well as communities. To determine whether interventions had an effect on the prevalence of
      malaria in the area, the baseline prevalence data will be compared with the evaluation data.
      Also a cost benefit analysis will be conducted by comparing what the NMCP put in in previous
      years to treat malaria to what it would spend if MTTT is implemented.

      Problems Anticipated

      It is anticipated that ACTs and RDTs supplies could delay. In order to avoid this, the
      investigators have approached the national malaria control programme to arrange for drugs and
      RDTs supply through the Eastern Regional Store. The investigators anticipate the number
      allocated to houses in the communities could be wiped and so the data for each house is
      linked to the name of the house. This could enable easy tracing of the participants. In the
      field the investigators will use forms that already carry the names of the families following
      the census. Names of new people could be added.

      Project Management

      The PI will carry out day to day implementation and supervise of all aspect of the project.
      Co-PIs are part of the implementation team and will participate in the decision making at all
      stages of the project. The Research assistant will help in facilitating project logistics.
      The Regional/District Health Directorates through the health facility in Pakro will
      facilitate the work. The volunteers are community members that assist in data collection
      while the driver facilitates movements.

      Quality Assurance

      In order to ensure the quality of data collected, 20 volunteers will be trained and 14 will
      be selected for the project. The questionnaires will be pretested and corrections effected.
      All data collected will be cross checked by two persons in the fields. To avoid loss of data,
      all data from the field will be recorded in the data transfer sheet before being transferred
      to the data management unit. All ACTs and RDTs will be procured from the National Malaria
      Programme through the Eastern Region medical store. The expiry dates for all procurements
      made will be verified.

      Ethical Consideration

      The ethical clearance for this study will be sought from the NMIMR-IRB

      Consent Procedure

      The investigators will obtain consent at different levels. Administrative authorization will
      be obtained from the Ghana Health Service. There will be community consent given by the
      chiefs, households consent given by the head or parents/caretakers for children below 18
      years, individual assent for 12-17 years old and consent for adults in each household. People
      from 18 years old are considered as Adults.

      Privacy and confidentiality

      All information/samples obtained from participants and their results will be kept
      confidential and not be released to a third party.

      Data storage and Usage

      This information will be stored in a secure location at the Epidemiology Department of NMIMR.
      Some staff of Epidemiology Department of NMIMR may access the data for research purposes
      only, such as malaria prevalence studies in asymptomatic individuals. Findings will be
      published with no reference to any personal identifiers. The data collected will be stored
      for a period of five years at NMIMR.

      Data ownership

      Data resulting from this study is own by the NMIMR.

      Risk

      There is no health threatening risk. Some participants may vomit within five minutes after
      taking the ACTs. It is assumed that if a patient vomits within five minutes he/she has not
      absorbed an acceptable quantity of the medicine. In this case the treatment will be repeated.
      Some other patients may show adverse reactions after taking the drugs such as stomach upset,
      dizziness, nausea, body weakness, etc. In other to cross check for some of these adverse
      events, the team will monitor volunteers for four days following treatment.

      Conflict of Interest

      The PI and co-PIs declare no conflict of interest in the execution of this project.

      Benefits

      All confirmed malaria parasitaemia cases will be treated for free. Continuous monitoring and
      treatment of confirmed cases will improve the health of residents. The study will reduce
      household spending on malaria thereby free some funds to be spent on other household items.
      This project could reduce the malaria related burden in the implementing communities.
    

Intervention name(s): Artemisinin Combination Therapy ACTs
Intervention type(s): Combination Product
Intervention description(s): All participants will be tested using RDTs and all confirmed cases will be treated with ACTs. The ACT regimen use at each time will be the one the National Malaria Control Programme will be using at that particular moment.
Intervention MeSH terms: Artemisinins; Artemisinin
Intervention model: Single Group Assignment
Intervention model description: The interventions are designed to compare the baseline to evaluation findings. There are two components to this implementation study a) The longitudinal (cohort) study: This is basically the prevalence surveys to be conducted with the selected cohort of children 6 months to 15 years - at baseline and before each of the subsequent MTTT rounds. b) The Survey involves using structured questionnaire to interview caretakers of children under five to solicit their views on the implementation process perceived benefits and challenges etc. Though the target group is children from 6 months to 15 years of age, all parasitised adults will be cleared of the parasite during the interventions as well to reduce the parasite reservoirs. Prevalence of malaria trends in cohort group over the study period will reveal the effect of MTTT scale-up on the children 6 month to 15 years. Between interventions, the teams will conduct homes-based management of malaria for confirmed febrile cases.
Masking: None (Open Label)
Primary purpose: Screening
Keywords: Impact; mass testing; treatment; tracking; Malaria prevalence; Children; Pakro Ghana