The Influence of Silicone Oil on Nerve Fiber Layer Thickness After Pars Plana Vitrectomy
Condition: Rhegmatogenous Retinal Detachment; Toxic Effect of Silicone; Glaucoma Due to Silicon Oil
MeSH terms: Retinal Detachment
Study type: Observational

Summary: 
      The aim of the study is to evaluate the influence of silicone oil on thickness of the retinal
      nerve fiber layer by using optical coherence tomography (OCT) in patients following pars
      plana vitrectomy.
    

Detailed description: 
      The aim of the study is to evaluate the influence of silicone oil on thickness of the retinal
      nerve fiber layer by using optical coherence tomography (OCT) in patients following pars
      plana vitrectomy.

      The study will include 60 patients with a temporary silicone oil tamponade who will be
      surgically treated with pars plana vitrectomy for rhegmatogenous retinal detachment and
      proliferative vitreoretinopathy. All subjects will be subdued to complete ophthalmologic
      examinations, measurements of the retinal nerve fiber layer thickness by an OCT examination,
      tests of the visual field with the use of an Octopus computed perimeter (automated static
      perimetry) and FDT-perimetry - both prior to the surgery, and on control visits for check-up
      during the postoperative period.

      All results provided by postoperative examinations will be compared with one another.

      The study is expected to provide data on the effect of the silicone oil on thickness of the
      retinal nerve fiber layer. It is also planned to show possibilities and advantages of OCT as
      a method of choice in the follow-up of patients with intraocular silicone oil tamponade.
    

Intervention name(s): Optical coherence tomography; Local medical treatment of raised intraocular pressure
Intervention type(s): Other; Drug
Intervention description(s): Optical coherence tomography will be performed in all study patients following pars plans vitrectomy and silicone oil tamponade. A fellow eye of each patient will serve as a control. Each patient enrolled in a study will receive 4 measurements:
On 7th postoperative day
On 30th postoperative day
On 90th postoperative day
On 180th postoperative day; In patients with raised intraocular pressure following medications will be employed in order to control the intraocular pressure:
Cosopt (dorzolamide hydrochloride-timolol maleate ophthalmic solution; b.i.d.) Ganfort (Bimatoprost, timolol maleate ophthalmic solution; once daily) Alphagan (Brimonidine ophthalmic solution; b.i.d.) In patients with intraocular pressure less than 27 mmHg Alphagan will be prescribed. In patients with intraocular pressure greater than 27 mmHg either Cosopt, or Ganfort will be prescribed under the discretion of treating physician. If intraocular pressure in patients treated with either Cosopt or Ganfort does not drop under 21 mmHg, Alphagan will be added.
Other intervention name(s): Cirrus HD OCT ( Carl Zeiss Meditec, Dublin, CA ); 1. Cosopt; 2. Ganfort; 3. Alphagan
Intervention MeSH terms: Brimonidine Tartrate
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        tertiary care clinic
      
Keywords: Rhegmatogenous retinal detachment; Pars plana vitrectomy; Silicone oil; Retinal nerve fibre layer