bioihbjkbjnl/mcl2 huggingface dataset:
Local Effects of Acupuncture and Nerve Conduction Studies
Condition: Carpal Tunnel Syndrome
MeSH terms: Carpal Tunnel Syndrome; Syndrome
Study type: Interventional

Summary: 
      Thus study aims to characterize the local, nerve-specific effects of acupuncture on the
      median and ulnar nerves in the forearm, using nerve conduction studies and quantitative
      sensory testing. All participant will have carpal tunnel syndrome and the affected median
      nerve will be compared to the healthy ulnar nerve. Additionally, we aim to compare the local,
      nerve-specific effect of manual acupuncture to that of low-frequency electroacupuncture and
      of high-frequency electroacupuncture.
    

Detailed description: 
      The purpose of this study is to measure the local effects of acupuncture on the median and
      ulnar nerves in patients with median neuropathy at the wrist (carpal tunnel syndrome), using
      nerve conduction studies (NCS) and quantitative sensory testing (QST) as outcomes. Our
      secondary aim is to compare acupuncture's effect on the functioning of a diseased nerve
      (median nerve in CTS) to its effect on a healthy nerve (ulnar). Additionally, we aim to
      compare the local, nerve-specific effect of manual acupuncture to that of low-frequency
      electroacupuncture and of high-frequency electroacupuncture.

      In a mechanistic study of acupuncture, 60 subjects with carpal tunnel syndrome (CTS) will be
      randomized to manual acupuncture (MA), low-frequency electroacupuncture (LF-EA) and
      high-frequency electroacupuncture (HF-EA) groups. Baseline measurements will consist of QST
      (vibration and cold detection thresholds), as well as NCS of both median and ulnar nerves.
      Then, each group will undergo acupuncture to the median nerve (Pericardium channel points)
      and to the ulnar nerve (Heart channel points), one week apart, order counterbalanced,
      followed by post-acupuncture NCS and QST measurements in both nerves' territories.
    

Intervention name(s): MAC acupuncture needles; Electrostimulator 6c.Pro, Pantheon Research, Venice, CA
Intervention type(s): Device; Device
Intervention description(s): Sterile single-use MAC acupuncture needles (0.22 x 25 mm, TianJin Haing Lim Sou Won Medical Equipment Co, Ltd, South Korea. Used for Manual Acupuncture
Used for: Manual Acupuncture to PC3, PC5 or HT3, HT4 for 20 min; Electrostimulator used for delivery or Low-Frequency or High-Frequency Electroacupuncture
Used for Interventions:
Low-frequency Continuous Electroacupuncture to PC3, PC5 or HT3, HT4 for 20 min AND High-frequency Continuous Electroacupuncture to PC3, PC5 or HT3, HT4 for 20 min
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Other
Keywords: Acupuncture; Electroacupuncture; Nerve Conduction Studies; Quantitative Sensory Testing
Study of the Ability of a Flu Vaccine to Prevent Flu Infection
Condition: Influenza
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate how effective the vaccine is at preventing subjects
      developing flu symptoms after they are directly exposed to flu virus. The study will also
      evaluate how well the vaccine is tolerated at sites where administrations are given, any
      effects it may have on subjects' wellbeing and whether it can produce antibody responses in
      the body
    

Detailed description: 
      Influenza is a contagious disease of the upper airways and the lungs. It rapidly spreads
      around the world in seasonal epidemics, killing hundreds of thousands of people and having
      high economic consequences due to healthcare costs and lost productivity. Each year
      governments recommend groups who are at risk of influenza or its complications to receive
      influenza vaccination. Current vaccine supply is not sufficient to meet the demand if this
      recommendation were to be taken up by all. This study will evaluate PowderMed's Particle
      Mediated Epidermal Delivery (PMED) DNA vaccine for influenza as a potential alternative to
      existing vaccine technologies. This study will assess how effective two different PMED
      vaccine combinations are at preventing subjects developing influenza following exposure to
      flu virus 56 days after a single dose of vaccine.
    

Intervention name(s): Trivalent DNA vaccine with and without pPJV2012 administered by PMED
Intervention type(s): Biological
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Prevention
Keywords: DNA vaccine; influenza; immunogenicity; tolerability; PMED; efficacy; challenge virus
BD FlowSmart™ Subcutaneous Insulin Infusion Set User Preference and Claims Study
Condition: Type 1 Diabetes Mellitus
MeSH terms: Diabetes Mellitus, Type 1
Study type: Observational

Summary: 
      Continuous Subcutaneous Insulin Infusion (CSII) via insulin pump therapy has been shown to
      improve quality of life and glucose control in many patients with diabetes opting for this
      treatment modality. Despite significant innovation and advancement in pump technology,
      insulin infusion sets have been an area where innovation has been significantly lacking with
      no clinical studies performed prior to product launches.

      BD has developed a subcutaneous infusion set with FlowSmart™ Technology designed to address
      patient comfort, insulin delivery and flow interruptions. According to preliminary animal and
      clinical studies, this technology results in lower infusion pressure indicating more
      consistent insulin delivery.

      The FlowSmart infusion set has been previously tested in prototype form with healthy
      non-diabetic subjects with the sets inserted by nurses, and with CSII-using patients who
      self-inserted the FlowSmart infusion set in a clinical research setting.

      The purpose of this study is to determine if insulin pump users prefer using the BD FlowSmart
      infusion set compared to their current set with respect to insertion pain and wear comfort.
    


Intervention name(s): FlowSmart Infusion Set; Current Infusion Set
Intervention type(s): Device; Device
Intervention description(s): Use of set for subcutaneous insulin infusion, with set change every three days.; Use of set for subcutaneous insulin infusion, with set change every three days.
Observational model: Case-Crossover
Time perspective: Prospective
Study population: 
        Approximately 75 subjects with type 1 diabetes currently on CSII will participate in the
        study
      
Keywords: infusion set; continuous subcutaneous insulin infusion
Effects of Alcohol History on Effects of Nitrous Oxide - 9
Condition: Alcohol-Related Disorders; Opioid-Related Disorders; Substance-Related Disorders
MeSH terms: Substance-Related Disorders; Opioid-Related Disorders; Alcohol-Related Disorders
Study type: Interventional

Summary: 
      The purpose of this study is to conduct experiments to examine subjective and reinforcing
      effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug
      abusers and preference procedures will be used to assess reinforcing effects. Comparisons
      between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To determine
      effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous
      oxide in healthy volunteers.
    


Intervention name(s): 0% N2O and 10% N2O; 0% N2O and 20% N2O; 0% N2O and 30% N2O; 0% N2O and 40% N2O
Intervention type(s): Drug; Drug; Drug; Drug
Intervention MeSH terms: Nitrous Oxide
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Keywords: nitrous oxide; subjective effects; ethanol; healthy volunteer
Tertiary Prevention by Exercise in Colorectal Cancer Therapy
Condition: Colorectal Cancer
MeSH terms: Colorectal Neoplasms
Study type: Interventional

Summary: 
      The purpose of this study is to determine the feasibility of a one year exercise training
      program in post-surgical patients with colorectal cancer.
    

Detailed description: 
      Apart from a genetic predisposition lifestyle factors (low physical activity, nutrition, and
      obesity) increase the risk of colorectal cancer. Furthermore, in observational studies
      increased physical activity has shown to improve the prognosis in patients after the
      diagnosis of colorectal cancer. However, there are currently no prospective randomized
      controlled trials which prove the causal relationship between exercise and prognosis in
      colorectal cancer patients. The long-term aim of this study is to evaluate whether physical
      activity of ≥ 18 MET-h (Metabolic equivalent task-hours) per week significantly improves
      disease free survival in colorectal cancer survivors (stage UICC II/III). In the first
      instance, structure-, process- as well as outcome-characteristics need to be investigated
      within a feasibility study (F-PROTECT). Essential aims are to establish collaborations with
      clinics and training centres, to achieve the required recruitment numbers, and to conduct the
      training intervention.
    

Intervention name(s): Physical activity
Intervention type(s): Behavioral
Intervention description(s): The patients will perform increasing volumes of moderate intensity endurance (e.g. walking, cycling) exercise, leading up to 18 MET-hours per week by the end of three months. Patients will then maintain this activity level for the remaining 9 months, with reduced supervision.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: colon; cancer; prevention; exercise; physical activity; rectal
The Influence of Sleep Education With Social Media Reminders on the Sleep Quality in Adolescents
Condition: Adolescent Behavior
Study type: Interventional

Summary: 
      Objective: This study aimed to determine the effect of sleep education, supported and
      unsupported with social media reminders, on sleep quality in 14-18 age group adolescents.

      Design: This study is in a single-blind randomized controlled design. The study was carried
      out between October 2019 and January 2020.

      Participants: The sample of this study consisted of 60 students randomly selected from three
      Anatolian High Schools in the city center. The students were divided into 3 groups of 20
      people each (Experiment 1, Experiment 2, and Control). According to the scan result,
      adolescents who have sleep quality (PSQI>5 and CASQ>16), use Smartphone and the internet,
      have no chronic diseases and obesity, and have no mental problems were included in the study.
      Adolescents who use sleeping pills or any other medication and have communication obstacles
      were excluded from the study. The study was completed with 55 adolescents due to the
      separation of 5 adolescents during the experiment.

      Intervention: The sleep education group, which was unsupported with social media reminders,
      was given sleep education for 30 minutes once a week for four weeks at school. In addition to
      the education at school, information messages and warnings were sent to the sleep education
      group, which was supported with social media reminders, via WhatsApp. The control group did
      not receive any intervention other than taking measurements of sleep parameters once a week.

      Main Outcome(s) and Measure(s): The data were collected with Pittsburgh Sleep Quality Index,
      Cleveland Adolescent Sleepiness Questionnaire, Adolescent Sleep Habits Form and MI Band 3
      device.
    

Detailed description: 
      The application of the research was planned according to the literature review and
      recommendations of the cognitive behavioral therapy approach. Sleep-related CBT practices
      consist of stimulus control, sleep restriction, relaxation techniques, managing sleep-related
      concerns, sleep hygiene education, and paradoxical intention. CBT practices consist of
      stimulus control and sleep hygiene education were used in this study. The sleep hygiene
      education that is part of the CBT method was used in the sleep education given to the
      Experiment 1 group. The sleep hygiene education that is part of the CBT method and the
      written stimulus control applications with WhatsApp was performed twice a day in the
      Experiment 2 group.
    

Intervention name(s): Sleep Education
Intervention type(s): Behavioral
Intervention description(s): A single-blind school- based randomized controlled design
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Effects of High Voltage Electrical Stimulation, Shortwave Diathermy and Kinesiotherapy on Arterial Blood Flow in the Lower Limbs of Diabetic Women
Condition: Diabetes; Peripheral Arterial Disease
MeSH terms: Peripheral Arterial Disease; Peripheral Vascular Diseases
Study type: Interventional

Summary: 
      Peripheral arterial disease (PAD) is a pathological condition limiting, resulting from a
      narrowing or occlusion of the artery diameter due to aneurysms, inflammation, atherosclerosis
      and thromboembolic events. One of the main risk factors for the development of DAP is
      diabetes mellitus due to its relation to the process of atherogenesis. Thus, the objective of
      this study is to evaluate the effects of three treatment modalities for PAD on the blood flow
      velocity. It is a crossover study. Fifteen women with diabetes receive three types of
      treatment, the order defined according draw: high voltage electrical stimulation, shortwave
      diathermy and kinesiotherapy. The blood flow of the lower limb will be assessed by Doppler
      ultrasound. The hypothesis of this study is that physical therapy resources increase the
      circulation of the lower limb.
    


Intervention name(s): high-voltage electrical stimulation; Kinesiotherapy; shortwave diathermy
Intervention type(s): Other; Other; Other
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Physical Therapy Modalities; Electric Stimulation Therapy; Hyperthermia, Induced; Diabetes Mellitus
Vitamin D, Oxidative Stress and Inflammation in Hemodialysis
Condition: Oxidative Stress; Inflammation; Vitamin D Deficiency
MeSH terms: Vitamin D Deficiency; Inflammation
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      Vitamin D deficiency is now considered a global problem in general population, but it seemed
      to be more prominent in chronic kidney disease (CKD) patients, especially those on regular
      hemodialysis. Being a key regulator in mineral metabolism, there's also emerging evidences
      linking vitamin D deficiency with inflammation and oxidative stress, which are both
      recognized as constant threats to cardiovascular outcomes in hemodialysis patients.

      It's prospective, randomized trial that's carried out to evaluate the effect of weekly
      versus, monthly oral cholecalciferol, on vitamin D (25(OH)D) levels, oxidative stress
      markers, inflammatory markers and secondary hyperparathyroidism in hemodialysis patients.
      Fifty eligible hemodialysis patients were randomly assigned to either Group A (Oral 50.000IU
      Cholecalciferol, once weekly) or Group B (Oral 200.000IU Cholecalciferol, once monthly), for
      3 months. Serum levels of (25(OH)D), serum malondialdehyde (MDA), serum superoxide dismutase
      (SOD), serum high sensitive (hsCRP), calcium, phosphorus, and intact parathormone (iPTH)
      levels, were all assessed at baseline and at the end of the study
    


Intervention name(s): Cholecalciferol
Intervention type(s): Drug
Intervention description(s): native form of Vitamin D.
Intervention MeSH terms: Cholecalciferol; Vitamin D
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Comparison of Early Caries Detection in Children Utilizing an Electrical Conductance Device and the Gold Standard of Visual-tactile Technique.
Condition: Dental Caries in Children
MeSH terms: Dental Caries
Study type: Observational [Patient Registry]

Summary: 
      The purpose of this study is to evaluate a methodology for detecting early forming cavities
      in children that is more accurate and reliable than the gold standard used by dentists around
      the world. The new method uses an electrical current device to detect early enamel mineral
      loss before it can develop into a cavity. The manual gold standard is for a dentist to probe
      the surfaces of the teeth with a fine pick, searching for areas of defect.
    


Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Children ages 6 - 9 years.
The Effect of Mobile Online Training Applied to Patients With Diabetes on Insulin Therapy
Condition: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 1
Study type: Interventional

Summary: 
      This study aims to investigate the effect of health belief model-based mobile online training
      applied to patients with diabetes on insulin therapy.
    

Detailed description: 
      Intervention and control group participants were invited to the Endocrinology and Metabolic
      Diseases Outpatient Clinic for a pre-test. n addition, each group was given insulin injection
      practice training using an insulin injection model. Whether the application was correct,
      incomplete, or incorrect was recorded on the observation form by the diabetes nurse. The
      web-based "Insulin Guide" mobile application prepared by the researcher was installed on the
      phones of the intervention group participants. They were asked to use this application for
      three months, at least three hours a week. Participants were followed up through the
      application. Participants who did not use the application were informed by SMS or phone and
      asked to use the application. Participants who did not use the application were excluded from
      the study. No intervention was made for the control group participants. At the end of three
      months, the participants in the intervention and control groups were invited to the
      Endocrinology and Metabolic Diseases Outpatient Clinic for a post-test. Both groups were
      asked to practice again on the insulin injection model. Whether the application was correct,
      incomplete, or incorrect was recorded on the observation form by the diabetes nurse.
    

Intervention name(s): Health Belief Model-Based Mobile Online Training
Intervention type(s): Behavioral
Intervention description(s): Health Belief Model-Based Mobile Online Training
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Diabetes; web-based mobile training; insulin therapy; insulin self-management; insulin injection skill; health belief model
Phase 1 ID93 + GLA-SE Vaccine Trial in BCG-Vaccinated Healthy Adult Volunteers
Condition: Pulmonary Tuberculosis
MeSH terms: Tuberculosis; Tuberculosis, Pulmonary
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine the safety, tolerability, and immunogenicity in
      BCG-vaccinated healthy adult subjects of an investigational vaccine being developed for the
      prevention of pulmonary tuberculosis.
    


Intervention name(s): ID93 + GLA-SE; Placebo
Intervention type(s): Biological; Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Tuberculosis; TB; Pulmonary; Vaccine; Adjuvant
Study to Assess Safety, Tolerability and Efficacy of SC Administered MBL949 in Obese Participants With or Without T2DM
Condition: Obesity
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a multi-center, randomized, placebo-controlled, participant-and-investigator-blinded,
      sponsor open-label study in obese participants with or without Type 2 Diabetes Mellitus.
    

Detailed description: 
      The study comprises a screening/baseline period of up to 35 days (5 weeks), a 14-week
      treatment period in which participants will be administered MBL949 or placebo at 8 biweekly
      intervals starting on Day 1 and a 10-week follow-up period
    

Intervention name(s): MBL949; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): subcutaneous injections administered for 14 weeks; Placebo Comparator to MLB949
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Type 2 diabetes mellitus; weight loss
Comparison of Pain Levels in Fusion Prostate Biopsy and Standard TRUS-Guided Biopsy
Condition: Pain Due to Certain Specified Procedures; Prostate Cancer; Biopsy
MeSH terms: Prostatic Neoplasms
Study type: Interventional

Summary: 
      The aim of this study was to compare the pain levels in transrectal ultrasound (TRUS)-guided
      standard 12-core prostate biopsy (SPB) and multiparametric prostate magnetic resonance
      imaging (MpMRI)-guided fusion prostate biopsy (FPB).
    

Detailed description: 
      The study included patients that underwent prostate biopsy under local anesthesia
      (intrarectal 2% lidocaine gel + periprostatic nerve block) due to suspected prostate cancer.
      Patients detected with a Prostate Imaging Reporting and Data System score (PIRADS) ≥3 lesion
      on MpMRI underwent MpMRI-guided FPB (Group I) and the patients who had no suspected lesions
      or had a PI-RADS <3 lesion on MpMRI underwent TRUS-guided SPB (Group II). Pain assessment was
      performed using Visual Analog Scale (VAS) 5 min after the procedure. Following the procedure,
      the patients were asked to indicate the most painful biopsy step among the three steps (1:
      insertion of the probe into the rectum, 2: probe manipulation, 3: the piercing of the biopsy
      needle).
    

Intervention name(s): Standard transrectal 12 core biopsy; MRI- US fusion prostate biopsy (FPB)
Intervention type(s): Procedure; Procedure
Intervention description(s): TRUS-guided SPB was performed by obtaining 12 core samples in each patient. 6 cores from left and right. the cores labeled as, apex, mid, base, apex far lateral, mid far lateral and base far lateral; FPB was performed by obtaining 10-12 core samples in each patient, followed by the acquisition of 2-4 core samples for each suspected lesion detected on MpMRI (combined biopsy)
Other intervention name(s): Group 2; Group 1
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: pain levels after standard transrectal prostate 12 core biopsy and MRI -US fusion prostate biopsy were detected and compared in 2 groups.
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: fusion; prostate; biopsy; pain