Comedone Extraction and Oral Doxycycline In The First Line Treatment of Moderate Acne Vulgaris
Condition: Acne Vulgaris
MeSH terms: Acne Vulgaris
Study type: Interventional
Phase: Phase 1

Summary: 
      The objective of the study was to evaluate the effectiveness of comedone extraction compared
      to oral antibiotics as the main therapy of moderate acne vulgaris (MAV); and to determine the
      expression of HIF-1 alpha by examining the immunohistochemistry and ELISA as a sign of
      hypoxia/anoxia in MAV lesion. This was a randomized, placebo-controlled clinical trial that
      was performed in 2015 at three different dermatology clinics in Indonesia, Cipto Mangunkusumo
      Hospital Jakarta, Gatot Soebroto Army Hospital Jakarta, and PT. Mattel Indonesia, Cikarang.
      One hundred and twenty eight subjects with moderate acne vulgaris were recruited and
      randomized to receive either oral doxycycline or comedone extraction for six weeks. Subjects
      who had acne lesion and the back area were offered skin lesion biopsy to evaluate
      immunohistochemistry and ELISA before administration of medication. The main outcome was
      total reduction of inflammatory and non inflammatory lesions, evaluated every two weeks.
    

Detailed description: 
      Acne vulgaris (AV) is a polymorphic disease, characterized by inflammatory and
      noninflammatory lesions. Systemic antibiotics play a role as the first line therapy of
      moderate acne vulgaris treatment. Since bacterial resistance tends to increase, alternative
      therapy for moderate acne vulgaris is needed.

      This study aims to evaluate the effectiveness of comedone extraction compared to oral
      antibiotics as the main therapy of moderate acne vulgaris; and to etermine the expression of
      HIF-1 alpha by examining the immunohistochemistry and ELISA as a sign of hypoxia/anoxia in
      MAV lesion.

      This was a randomized, placebo-controlled clinical trial that was performed in 2015 at three
      different dermatology clinics in Indonesia, Cipto Mangunkusumo Hospital Jakarta, Gatot
      Soebroto Army Hospital Jakarta, and PT. Mattel Indonesia, Cikarang.

      One hundred and twenty eight subjects, aged between 15 and 50 years, with moderate acne
      vulgaris were recruited and randomized to receive either oral doxycycline (100 mg) or
      comedone extraction for six weeks. Subjects who had acne lesion and the back area were
      offered skin lesion biopsy to evaluate immunohistochemistry and ELISA before administration
      of medication.

      At each follow-up visit, subjects were asked to grade the overall response and questioned
      regarding adverse events. The objective or main outcome was total reduction of inflammatory
      and noninflammatory lesions.
    

Intervention name(s): Doxycycline Capsule; Comedone extraction
Intervention type(s): Drug; Procedure
Intervention description(s): Doxycycline capsule 100 mg/day, tretinoin cream 0.05% on face every night, benzoyl peroxide gel 2.5% on face in the morning and afternoon.; Comedone extraction, tretinoin cream 0.05% on face every night, benzoyl peroxide gel 2.5% on face in the morning and afternoon.
Intervention MeSH terms: Doxycycline
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: comedone extraction; oral doxycycline; moderate acne vulgaris; HIF-1 alpha expression