bioihbjkbjnl/mcl2 huggingface dataset:
High-flow Oxygen Therapy During Exercise in Idiopathic Pulmonary Fibrosis
Condition: Idiopathic Pulmonary Fibrosis
MeSH terms: Pulmonary Fibrosis; Idiopathic Pulmonary Fibrosis; Fibrosis
Study type: Interventional

Summary: 
      Objectives:

        1. To evaluate endurance time during cardiopulmonary exercise test (CPET) performance
           comparing standard oxygen therapy to high-flow nasal cannula (HFNC) oxygen therapy in
           subjects with idiopathic pulmonary fibrosis (IPF) with exertional desaturation.

        2. To assess oxygenation level (peripheral and muscular) as well as dyspnea and fatigue
           during exercise in IPF subjects with exertional desaturation using oxygen
           supplementation with HFNC compared with standard oxygen supplementation.

      Method: multicenter crossover clinical trial. Patients with IPF presenting oxygen
      desaturation during the six-minute walking test (6MWT) (SpO2 mean ≤ 85%) will be included
      consecutively . Each subject evaluated will perform initially an incremental CPET to evaluate
      the patient's maximum exercise capacity. Supplemental oxygen will be applied to maintain SpO2
      >85% with a Venturi mask. Maximum exercise capacity and the appropriate final oxygen
      inspiratory fraction (FiO2) needed for the following tests will be determined.

      Posteriorly each patient will perform two constant load CPET (at 75% of the maximum workload
      achieved with the incremental CPET); one with standard oxygen therapy and the other one with
      HFNC oxygen therapy. Endurance time, dyspnea and leg fatigue and oxygen saturation
      (peripheral and muscular) will be recorded.

      Evaluation measures: Endurance time, dyspnea and leg fatigue (Borg scale), and oxygen
      saturation.
    


Intervention name(s): Oxygen
Intervention type(s): Drug
Intervention description(s): High-flow nasal cannula oxygen therapy vs. standard oxygen therapy
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: exertional desaturation; high-flow nasal cannula
Long Term Follow-up Study With Keppra XR (Levetiracetam XR) for Partial Seizures
Condition: Epilepsy
MeSH terms: Seizures
Study type: Interventional
Phase: Phase 3

Summary: 
      To provide continued treatment of Keppra XR (Levetiracetam XR) and to assess the long term
      safety of Keppra XR in subjects with partial onset seizures.
    


Intervention name(s): Keppra XR (Levetiracetam XR)
Intervention type(s): Drug
Intervention description(s): 500 mg tablets, 1000 - 3000 mg/day, flexible dosing for duration of the study (planned: approximately 6 months-3 years).
Other intervention name(s): Keppra XR
Intervention MeSH terms: Levetiracetam
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Keppra XR; Levetiracetam XR; long term; partial seizures
Home-based -Virtual Reality Intervention for Stroke Rehabilitation
Condition: Stroke
MeSH terms: Stroke
Study type: Interventional

Summary: 
      On-going rehabilitation is needed to maintain and improve the weaker upper extremity
      following stroke. Community rehabilitation programs for stroke individuals in the chronic
      stage are often difficult to be implement. Consequently, many individuals remain without
      structured interventional programs. Self-training programs, where individuals can
      independently continue to exercise at home, might answer this challenge. However, since
      exercising alone is boring and not motivating, individuals often stop the prescribed
      exercises and remain inactive. The use of video-games for self-training might answer this
      challenge.

      Therefore, the investigators aimed to assess the feasibility of using video-games for
      self-training after stroke. Specifically the investigators aim to compare the (1) training
      time, (2) satisfaction and (3) effectiveness of a self-training program using video-games
      compared to a traditional self-training program.
    

Detailed description: 
      This is a single-blind randomized controlled trial with four assessments; two before and two
      following the 5-week self training intervention.

      Individuals are requested to perform the self training (video-games or traditional exercises)
      60 minutes a day for 5 weeks.
    

Intervention name(s): self-training using video-games; traditional self-training
Intervention type(s): Other; Other
Intervention description(s): Individuals will receive a video-game console and will be taught how to play the games.
They will be requested to play 60 minutes a day for 5 weeks.; Individuals will receive a manual and equipment and will be taught how to perform the exercises. They will be requested to perform the exercises 60 minutes a day for 5 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
A Study on the Changes of the Biological Rhythm by Display Image Modulation
Condition: Circadian Rhythm Phase Shift
Study type: Interventional

Summary: 
      Effects of Smartphone Use at Night with Light Emitting Diode Display With and Without Blue
      Light in Healthy Adults: A Randomized, Double-blind, Cross-over, Placebo-controlled
      Comparison
    


Intervention name(s): smartphone display
Intervention type(s): Device
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Screening
Functional Performance Assessments in Overhead Athletes With Shoulder Injury
Condition: Sports Physical Therapy; Rehabilitation
MeSH terms: Shoulder Injuries
Study type: Observational [Patient Registry]

Summary: 
      Background & Purpose: Shoulder injuries are commonly seen in overhead athletes due to the
      mechanism of the repetitive and high velocity movement. While the injury usually cost the
      lost of time in playing, making the decision of the time to return to play (RTP) is a
      critical issue that should be standardized and objective. However, current studies showed
      that the decision making of RTP is so complicated that there's lack of objective measurements
      especially for upper extremity injuries. So, investigating the usage of convenient and valid
      tools, functional performance assessments for assessing the ability to RTP is the main
      objective of this study.

      Objective: There are 2 objectives for this study: (1) to investigate the difference between
      RTP group and non-RTP in overhead athletes with shoulder injury; (2) to investigate the
      responsiveness of the functional performance assessment in return to play for overhead
      athletes with shoulder injury. Methods: Overhead athletes with shoulder injury or surgery
      which leads to temporary leaving to the sport within will be recruited in this study. The
      shoulder joint range of motion (flexion, extension, external/internal rotation, and
      abduction), shoulder muscle strength (flexors, abductors and external/internal rotators),
      patient-reported outcome (KJOC and DASH questionnaire) and functional performance assessments
      (FMS, YBT-UQ, CKCUEST, USSP and TPUT) will be assessed at 6 months after the athlete was
      injured or received surgery, and at the time point if the athletes successfully complete at
      least one formal game or practice game (RTP group). If the athlete doesn't return within 12
      months after injury or surgery, the assess will be done at the 12th month after injury or
      surgery. Significance and Contribution: This study is going to provide an objective
      measurement value of functional performance assessment in injured overhead athletes,
      determining whether the strength, endurance or power of the upper extremity is good enough to
      return to the sport that the athlete played before this injury. The result is also expected
      to have significant contribution in the area of sports medicine in return to play especially
      in overhead athletes, which has limited evidence providing specific criteria and objective
      measurement value previously.
    


Intervention name(s): functional performance test
Intervention type(s): Diagnostic Test
Intervention description(s): Functional performance test is to test the ability of the athletes in functional movements
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Overhead athletes with shoulder injury
      
Keywords: sports; physical therapy; return to play; overhead athletes
A Pharmacokinetic and Safety Study of Paliperidone Palmitate (JNS010) in Participants With Schizophrenia
Condition: Schizophrenia
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to assess the pharmacokinetics (the study of the way a drug
      enters and leaves the blood and tissues over time) and safety of paliperidone palmitate in
      participants with schizophrenia (psychiatric disorder with symptoms of emotional instability,
      detachment from reality, often with delusions and hallucinations, and withdrawal into the
      self).
    

Detailed description: 
      This is a multicenter (when more than one hospital or medical school team work on a medical
      research study), open-label (all people know the identity of the intervention), randomized
      (the study drug is assigned by chance), parallel-group (Each group of participants will be
      treated at the same time), comparison study to assess the pharmacokinetics and safety of
      paliperidone palmitate (study medication) in participants with schizophrenia. The study
      comprises a 64-day Treatment period and a 155-day Follow-up period. The participants will be
      randomly assigned to one of the four study groups. The study medication will be administered
      on Days 1, 8, 36 and 64. Pharmacokinetics of the study medication will be assessed as primary
      outcome. Participants' safety will be monitored throughout the study.
    

Intervention name(s): Paliperidone palmitate
Intervention type(s): Drug
Intervention description(s): Paliperidone palmitate aqueous suspension for injection 0.5, 1.0, 1.5 milliliter equivalent to 50, 100, 150 mg paliperidone respectively as intramuscular injection on Days 1, 8, 36 and 64.
Other intervention name(s): JNS010
Intervention MeSH terms: Paliperidone Palmitate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Schizophrenia; Paliperidone Palmitate; JNS010
Aerobic Capacity Muscle Strength and Health Related Quality of Life in Children With Chronic Liver Disease
Condition: Chronic Liver Failure
MeSH terms: Liver Diseases; Liver Failure; End Stage Liver Disease
Study type: Interventional

Summary: 
      Physical therapy program for children with chronic liver disease consist of gait training,
      strengthening ex for UL&ll, stretching exercise to improve physical fitness and quality of
      life
    

Detailed description: 
      Intervention study for one group of children diagnosed with chronic liver disease ages more
      than 6ys, study include assessment and intervention, assessment of 6MWt, grip strength by
      hand held dynamometer, quadriceps strength by Lafayette, al children subjected to laboratory
      investigation pre and post of study completion, anthropometric measure, quality of life and
      fatigue assessment then all children will perform physical therapy program of gait training
      muscle strengthening for 8 week
    

Intervention name(s): Physical therapy exercise
Intervention type(s): Other
Intervention description(s): Endurance, strength and stretching training in Chronic liver disease children
Other intervention name(s): Designated physical therapy program
Intervention model: Single Group Assignment
Intervention model description: One group of children ages more than 6ys will recruited and assessed pre and post of study completion for 12week
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: aerobic capacity; chronic liver disease; muscle strength
LIKEST Study: Lipocet® in Adults With Primary Knee Osteoarthritis Grade 3-4
Condition: Primary Knee Osteoarthritis Grade 3 - 4
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional

Summary: 
      The purpose of this study is to assess the safety, tolerability and efficacy of Lipocet®
      (food supplement) in patients with primary knee osteoarthritis grade 3 - 4
    

Detailed description: 
      After being informed about the study, all patients giving written informed consent will
      undergo no more than a 1-week screening period to determine eligibility for study entry.
      Patients that meet inclusion criteria and do not have exclusion criteria will be randomized
      in a double-blind manner (participant and investigator) in a 1:1 ratio to Lipocet ® (once a
      day, 10 ml corresponding to 1500 mg of Cetylated fatty acids) or placebo (once a day, 10 ml)
      during 60 days of treatment.
    

Intervention name(s): Lipocet® (food supplement); Lipocet Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 1 sachet, 10 ml corresponding to 1500 mg of Cetylated fatty acids; Lipocet Placebo matching to Lipocet
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Osteoarthritis; Lipocet
Sonograms Enable Looking Forward - Home Examinations Led by Providers Validation Study
Condition: Fertility Risk
Study type: Interventional

Summary: 
      To demonstrate that clear, interpretable quality images of the ovaries and uterus can be
      generated using a portable transvaginal ultrasound scanner in the home environment, and that
      those images are interpretable by physicians with sufficient clarity to estimate approximate
      antral follicle count (i.e., appropriate for age) and to observe submucosal fibroids. Study
      aims to prove that images taken when ultrasound is performed by a woman herself (with HCP
      supervision via telemedicine) and images taken when ultrasound is administered by an HCP are
      of comparable quality. Study population reflects real-world patient characteristics and
      includes both general-population and submucosal fibroid positive controls.
    

Detailed description: 
      Today, pro-fertility information is generally unavailable to healthy women; clinically
      meaningful in-clinic testing is limited by physician availability and patient willingness to
      undergo testing in-clinic, while home testing is limited to hormonal bloodwork which is
      insufficient on its own and has high false positives. Sponsor is developing home telemedicine
      transvaginal ultrasound as part of a home fertility assessment. Sponsor wishes to demonstrate
      the ability to obtain interpretable images, in women of varying body habitus, reproductive
      age, and reproductive status.
    

Intervention name(s): Transvaginal ultrasound performed by a woman herself (with HCP supervision via telemedicine)
Intervention type(s): Device
Intervention description(s): Imaging performed by woman on herself with remote healthcare professional (HCP) supervision compared to images taken when same ultrasound is administered in person by HCP. The ultrasound device used is cleared for HCP-supervised use in environments where healthcare is provided by trained HCPs. No changes to the design or manufacture have been made for this study.
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Other
A Trial of BMS-512148 in Patients With Type 2 Diabetes Mellitus
Condition: Type 2 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this clinical research study is to learn if BMS-512148 is effective in
      controlling blood sugar levels as determined by HbA1c and fasting plasma glucose in patients
      who have been diagnosed with Type 2 diabetes. Patients should first try to control their
      diabetes with diet and exercise and should not have previously been treated for their
      diabetes (very short periods of time are acceptable). The safety of BMS512148 will also be
      studied
    


Intervention name(s): dapagliflozin; dapagliflozin; dapagliflozin; dapagliflozin; dapagliflozin; placebo; metformin
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Tablets, Oral, 2.5 mg, Once daily, 12 weeks.; Tablets, Oral, 5 mg, Once daily, 12 weeks.; Tablets, Oral, 10 mg, Once daily, 12 weeks.; Tablets, Oral, 20 mg, Once daily, 12 weeks.; Tablets, Oral, 50 mg, Once daily, 12 weeks.; Tablets, Oral, 0 mg, Once daily, 12 weeks.; Tablets, Oral, >/= 1500 mg, Once daily, 12 weeks.
Intervention MeSH terms: Metformin; Dapagliflozin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
A Pilot Study for the Brain Health Support Program
Condition: Dementia; Mild Cognitive Impairment; Subjective Cognitive Impairment; Pre-dementia; Dementia Prevention
MeSH terms: Dementia; Alzheimer Disease; Cognitive Dysfunction
Study type: Observational

Summary: 
      Prior studies have shown that programs that focus on promoting brain health and managing
      lifestyle risks (such as poor diet, obesity, physical inactivity, sleep issues, loneliness)
      may help in preventing or lowering the risk of dementia. To address this, investigators have
      developed the CAN-THUMBS UP program to conduct studies that target lifestyle risk and focus
      on dementia prevention. An online Brain Health Support Program (BHSP) has been developed. The
      BHSP is an educational program designed to teach about dementia. Before the full BHSP is
      offered to a large group, we are conducting an initial pilot study to help assess the
      usability of the program.
    


Intervention name(s): Brain Health PRO
Intervention type(s): Behavioral
Intervention description(s): The BHSP is an educational program designed to teach about dementia. It aims to provide best available evidence for lifestyle changes that can help lower dementia risk, and to provide specific recommendations for positive lifestyle changes (e.g., physical exercises to try at home, healthy recipes). The program was developed as a collaborative effort by Canadian investigators who have expertise in the different areas of dementia prevention, along with input from older-adult citizen advisors.
Other intervention name(s): Brain Health Support Program
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        This study will recruit it's cohort from various locations around Canada.
Ultrasound Guided Aspiration of Hydrosalpingeal Fluid and IVF-ET Outcomes
Condition: Infertility
MeSH terms: Infertility
Study type: Interventional
Phase: Phase 2

Summary: 
      The aim of this study is to determine whether the ultrasound guided aspiration of
      hydrosalpingeal fluid at the time of oocyte retrieval can improve the outcomes of IVF-ET .
    

Detailed description: 
      A Cochrane review of prospective randomized trials of laparoscopic salpingectomy confirmed
      the beneficial effect of laparoscopic salpingectomy on IVF ET outcomes in patients with
      hydrosalpinges. Surgery is not usually safe especially in patients with extensive adhesions,
      morbid obesity and previous multiple laparotomies. Other less invasive options for patients
      with hydrosalpinges as ultrasound guided aspiration of hydrosalpingeal fluid, antibiotics and
      hysteroscopic occlusion of fallopian tube were studied in order to find an alternative to
      salpingectomy. Although these methods are simple and getting popular,current data are
      inadequate to recommend these treatment options instead of salpingectomy. The aim of this
      study is to determine whether the ultrasound guided aspiration of hydrosalpingeal fluid at
      the time of oocyte retrieval can improve the outcomes of IVF-ET .
    

Intervention name(s): ultrasound guided aspiration of hydrosalpingeal fluid
Intervention type(s): Procedure
Intervention description(s): Under deep sedation, the retrieval of oocytes is done and then an aspiration needle is inserted into the hydrosalpinx under ultrasonographic guidance and suction is applied to aspirate the hydrosalpingeal fluid completely . If there are bilateral hydrosalpinges, the process is repeated on the opposite side.
Other intervention name(s): ultrasound guided Hydrosalpinx needle aspiration
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Infertility; Hydrosalpinx; IVF-ET
Effect of Neurodynamics Nerve Flossing on Femoral Neuropathy in Haemophilic Patients
Condition: Femoral Neuropathy in Haemophilic Patients
MeSH terms: Peripheral Nervous System Diseases; Femoral Neuropathy
Study type: Interventional

Summary: 
      To investigate the effect of Neurodynamics Nerve flossing on femoral neuropathy in patients
      with haemophilia

      Background: heamophilia is one of the serious chronic disorders in children and adolescents
      which results in less physical activities and restlessness hours than their peer.

      HYPOTHESES:

      This study will hypnotize that:

      Neurodynamics Nerve flossing will have a significant effect on femoral neuropathy in patients
      with haemophilia

      RESEARCH QUESTION:

      will the Neurodynamics Nerve flossing has an effect on femoral neuropathy in patients with
      haemophilia?
    

Detailed description: 
      Haemophilic patients with Femoral Neuropathy will be randomly divided in two equal groups
      control group which will receive conventional selected exercise program and study group will
      receive the same exercise training program in addition to Neurodynamics Nerve flossing three
      times per week for three successive months.

      The Evaluation will done pre and post interventions included:

      femoral nerve motor conduction velocity, muscle test For Iliopsoas and Quadriceps muscles and
      Pain visual analogue scale.
    

Intervention name(s): Neurodynamics Nerve flossing; conventional selected exercise program
Intervention type(s): Other; Other
Intervention description(s): Neurodynamics Nerve flossing for femoral nerve that includes two techniques inform of:
"slider technique" and the second is the "tensioner technique; Ultrasound therapy The flexibility exercises for iliopsoas & quadriceps The iliopsoas & quadriceps muscles strength exercise
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: control group which received conventional selected exercise program in form of Ultrasound therapy The flexibility exercises for iliopsoas & quadriceps The iliopsoas & quadriceps muscles strength exercise
and study group received the same exercise training program in addition to Neurodynamics Nerve flossing three times per week for three successive months
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Neurodynamics,; Nerve flossing;; femoral neuropathy; , haemophilia,