Efficacy of Injection Platelet-rich Fibrin(I-PRF) in Accelerate Alignment and Leveling
Condition: Orthodontic Pathological Resorption of External Root
MeSH terms: Tooth Resorption
Study type: Interventional

Summary: 
      the aim of this study is to evaluate the effectiveness of injection I-PRF to accelerate
      alignment and leveling of the upper anterior teeth and reduce the time required for
      treatment.
    

Detailed description: 
      What remains the most important and common question for adult patients who want to undergo
      orthodontic treatment is how long the treatment will take, as the period of orthodontic
      treatment may take between 18 and 24 months in some cases of malocclusion ,and this may cause
      discomfort for the patient and reduce cooperation during treatment in addition to the
      aesthetic problems associated with presence of bracket.

      the possibility of an increase of Enamel mineral dissolution and spread of dental caries
      ,gingival problems and this is due to the increase of the duration of orthodontic treatment.

      Orthodontic treatment begins with the leveling and alignment stage and constitutes an
      important part of the treatment stages, during which the teeth(incisal edges, cusps posterior
      teeth) are placed on one level and to achieve perfect points of contact between the teeth In
      some cases of malocclusion especially severe ones, this stage may take about 8 months
      therefore , the interest of orthodontics has increased in finding new methods and techniques
      in order to accelerate treatment, Various methods and techniques have been used to accelerate
      orthodontic treatment Which includes :biomaterial injection, surgical and physical methods.
      Yet, despite the effectiveness of some of these methods in accelerating dental movement ,each
      of its disadvantages and side effects on the patient therefore, attention must be paid to
      anther effective safe and simple non-traumatic method hence the idea of using platelet rich
      fibrin came.

      Platelet rich fibrin is a therapeutic approach and it is a new generation of platelet
      concentrates Which was introduced to the field of dentistry by choukroun in 2001 who
      developed this treatment technique.

      Platelet rich fibrin injection technology (I-PRF), which is obtained in liquid form for
      injection has been developed through the concept of reduced speed centrifugation .

      PRF is a biomaterial .Autologus is taken from a person's own blood.Unlike PRP, no external
      bioactive are added to active platelet. Rather, the blood sample remains normal. The
      importance and therapeutic benefits of platelet-rich fibrin come through the presence of key
      and other common elements that collectively contribute to the healing processes and
      regeneration of the soft and bone tissues represented by the presence of fibrin in the form
      of a matrix with large and significant numbers of leukocytes, cytokines, platelets, in
      addition to the participation of growth factors which play an important role in the processes
      of healing.

      Platelet rich fibrin is a simple, easy to apply and economical technique that does not
      require adding any substances to the blood sample as an anticoagulant.

      To date, there are no studies on the role that platelet rich fibrin injection can play in
      accelerating aligning and leveling the upper anterior teeth and reducing the time required
      for treatments Therefore the aim of study is to verify the effectiveness of injection I-PRF
      to accelerate alignment and leveling of the upper anterior teeth and reduce the time required
      for treatment
    

Intervention name(s): injection I-PRF
Intervention type(s): Other
Intervention description(s): injection I-PRF with brackets
Other intervention name(s): control Group
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A randomized controlled clinical study ,two parallel groups design. The research sample consisted of 18 patients (11 famales,7 males)Patients were randomly assigned to 2 groups using the sample randomization principle. Each group included 8 patient (9 control group applying brackets only)(9 group injection I-PRF with brackets).
Masking: None (Open Label)
Primary purpose: Health Services Research