Study of Blood and Cheek Cell Samples From Patients With Glioma
Condition: Brain and Central Nervous System Tumors
MeSH terms: Glioma; Nervous System Neoplasms; Central Nervous System Neoplasms
Study type: Observational

Summary: 
      RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory
      may help doctors learn more about changes that occur in DNA and identify biomarkers related
      to cancer. It may also help doctors predict how patients will respond to treatment.

      PURPOSE: This research study is looking at blood and cheek cell samples from patients with
      glioma.
    

Detailed description: 
      OBJECTIVES:

      Primary

        -  Determine factors related to glioma survival in patients from two population-based case
           series collected in the San Francisco Bay Area between August 1991 and April 1994
           (series 1) and May 1997 and August 1999 (series 2).

      Secondary

        -  Determine vital status for 879 patients in the two San Francisco Bay Area
           population-based series through July 2004.

        -  Determine survival as a function of established, potential, and yet unstudied prognostic
           indicators.

        -  Gather data to validate results from this study with information from adult glioma
           patients enrolled prospectively at the UCSF-Neuro-Oncology clinic and through series 3
           of the San Francisco Bay Area Adult Glioma Study; incorporate results from this study
           and other components of the SPORE into ongoing clinical investigations at the Brain
           Tumor Research Center and Neuro-Oncology Service at UCSF.

        -  Using funding from the organization Accelerate Brain Cancer Cure (ABC2), genotype
           several thousand single nucleotide polymorphisms (SNPs) from some study participants;
           assess these SNPs for potential relationship to glioma survival.

      OUTLINE: Medical records of patients registered to the California Cancer Registry or the
      Northern California Cancer Center SEER are reviewed for mortality and treatment information
      related to the brain tumor. Blood and buccal specimens are collected from patients with newly
      diagnosed disease who are being seen at the UCSF Neuro-Oncology Service. The specimens are
      used for polymorphism and tumor marker studies and other pertinent data. Tumor specimens and
      treatment information related to the brain tumor are also collected from the SPORE Tissue
      Core.

      Additional tumor makers are studied, including: chromosome 1p/19q, 7q studies; DNA repair and
      oxidative metabolism polymorphisms; and up to 2 tumor markers and 2 constitutive genotyping
      studies.
    

Intervention name(s): polymorphism analysis; laboratory biomarker analysis; medical chart review
Intervention type(s): Genetic; Other; Other
Keywords: adult anaplastic astrocytoma; adult diffuse astrocytoma; adult pilocytic astrocytoma; adult subependymal giant cell astrocytoma; adult anaplastic ependymoma; adult ependymoma; adult myxopapillary ependymoma; adult subependymoma; adult anaplastic oligodendroglioma; adult oligodendroglioma; adult brain stem glioma; adult giant cell glioblastoma; adult glioblastoma; recurrent adult brain tumor; adult gliosarcoma; adult mixed glioma; adult pineal gland astrocytoma; adult ependymoblastoma; adult medulloblastoma; adult supratentorial primitive neuroectodermal tumor (PNET); adult pineoblastoma; adult pineocytoma