Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients
Condition: Aggressive Periodontitis
MeSH terms: Periodontitis; Aggressive Periodontitis; Aggression
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to determine whether full-mouth disinfection is effective in the
      initial periodontal treatment of generalized aggressive periodontitis on clinical parameters,
      gingival crevicular fluid interleukin-1β (IL-1β) and interleukin-17 (IL-17) and periodontal
      pathogen levels compared with conventional initial periodontal treatment and full-mouth
      initial periodontal treatment.

      The investigators' hypothesis is to test whether full-mouth disinfection in the initial
      periodontal treatment of generalized aggressive periodontitis enhance the clinical,
      biochemical and microbiological parameters in comparison to conventional initial periodontal
      treatment and full-mouth initial periodontal treatment.
    

Detailed description: 
      The present study aimed to compare the efficacy of conventional initial periodontal treatment
      (C-IPT), full-mouth disinfection IPT (FMD-IPT) and full-mouth IPT (FM-IPT) and the levels of
      gingival crevicular fluid interleukin-1β (IL-1β) and interleukin-17 (IL-17), Aggregatibacter
      actinomycetemcomitans, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella
      intermedia, Parvimonas micra and Campylobacter rectus in patients with generalized aggressive
      periodontitis (GAgP) over 6-months period. Forty-two GAgP patients were randomly assigned
      into 3 groups. IPT was performed in a quadrant-wise manner at 1-week intervals in C-IPT, in 2
      sessions within 24 hours in FM-IPT, and in 2 sessions with application of chlorhexidine to
      the intra-oral niches within 24 hours in FMD-IPT. FMD-IPT group also used daily 0,2%
      chlorhexidine for 3 weeks. At baseline, 3 and 6 months clinical parameters consisting of
      plaque index, gingival index, probing depth, bleeding on probing and clinical attachment
      level were recorded, gingival crevicular fluid and microbiological samples were collected.
      Gingival crevicular fluid levels of IL-1β and IL-17 were analyzed using ELISA. The
      quantitative real-time polymerase chain reaction method was used for the quantitative
      detection of periodontal pathogens.
    

Intervention name(s): Klorhex® Gel, rinse and spray; Conventional IPT; Full-mouth IPT
Intervention type(s): Drug; Procedure; Procedure
Intervention description(s): Initial periodontal treatment was performed in 2 sessions with application of chlorhexidine to the intra-oral niches within 24 hours (Klorhex® Gel 1% for 10 minutes, Klorhex® Spray 0,2% and Klorhex® rinse 0,2% for 3 weeks).; Initial periodontal treatment was performed in a quadrant-wise manner at 1-week intervals.; Initial periodontal treatment was performed in 2 sessions within 24 hours.
Other intervention name(s): FMD; Q-SRP; FM-SRP
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Periodontal Debridement; Gingival Crevicular Fluid; Aggressive Periodontitis; Interleukin-1beta; Interleukin-17; Bacteria