bioihbjkbjnl/mcl2 huggingface dataset:
Hip and Knee Moments Normal and With Scoliosis
Condition: Scoliosis Idiopathic
MeSH terms: Scoliosis
Study type: Observational

Summary: 
      Kinetic analysis appears to be useful in providing objective information regarding the gait
      abilities of scoliotic patients which is difficult to be observed in a clinical setting.
      Objective: the aim of the study was to analyze the hip and knee peak abductor moments during
      gait in subjects with idiopathic scoliosis.
    

Detailed description: 
      The hip and knee abductors' moments normalized to body weight have been investigated in
      normal subjects and subjects with idiopathic scoliosis. The scoliosis group included a
      twenty-two-moderate idiopathic dorso-lumbar single scoliotic curve. The control group
      contained a normal twenty-two subjects. 3D motion analysis system and force plat were used
      for data collection for hip and knee abductor moment. MANOVA was used to study the difference
      between normal and scoliotic groups' hip and knee abductor moments in both lower limbs. at
      alpha level of significance of 0.05.
    

Intervention name(s): gait analysis
Intervention type(s): Other
Intervention description(s): Vicon nexus with MTI force plate form
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        normal subjects and subjects with moderate idiopathic scoliosis
      
Keywords: Idiopathic scoliosis-gait-moment
Pringle's Maneuver Versus Selective Hepatic Vascular Exclusion in Hepatectomy
Condition: Hepatocellular Carcinoma
MeSH terms: Carcinoma, Hepatocellular
Study type: Interventional
Phase: Phase 2/Phase 3

Summary: 
      To confirm that SHVE is a safe and effective procedure and it can prevent bleeding of the
      hepatic vein. To evaluate the recurrence and metastasis in HCC patients undergoing
      hepatectomy by SHVE.To evaluate that SHVE can improve survival in HCC patients or not.
    

Detailed description: 
      Hepatocellular carcinoma (HCC), a serious disease with high incidence at home and abroad
      still shows a rising trend. In recent decade, the overall survival rate of the disease has
      entered a platform stage with little advance despite diversified methods of treatment. The
      prognosis of HCC is not so satisfying.

      Intraoperative bleeding remains a major concern during liver resection. Blood loss usually
      occurs during parenchymal transection and reperfusion after Pringle's maneuver. The amount of
      blood loss and the need for blood transfusion have a detrimental effect on the short- and
      long-term prognosis.

      Portal triad clamping is sufficient in most situations to control bleeding during
      hepatectomy. However, it does not prevent backflow bleeding from hepatic veins, which may
      become troublesome or even hazardous. This is particularly true in tumors that are large or
      that have invaded into the branches of the major hepatic veins.

      SHVE completely isolates the liver from the systemic circulation with the advantage of
      preventing backflow hemorrhage or air embolism without having to resort to caval blood flow
      interruption of THVE.

      The purpose of the study is to assess the risk factors for the recurrence and metastasis in
      HCC patients undergoing hepatectomy by SHVE and to evaluate that SHVE can improve survival in
      HCC patients or not.
    

Intervention name(s): Selective Hepatic Vascular Exclusion; Pringle's Maneuver
Intervention type(s): Procedure; Procedure
Intervention description(s): Inflow occlusion with extraparenchymal control of major hepatic veins results in total liver isolation from the systemic circulation but without interruption of caval flow.; Hepatic pedical clamping is performed by encircling the hepatoduodenal ligament with a tape and then applying a tourniquet or a vascular clamp until the pulse in the hepatic artery disappears distally.
Other intervention name(s): SHVE group; Pringle's Maneuver group
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: hepatocellular carcinoma; hepatic vein; Surgical resection; occlusion; time to recurrence; overall survival
Differential Effects of Protein Quality on Postprandial Lipemia in Response to a Fat-Rich Meal in Type 2 Diabetes: Comparison of Whey, Casein, Gluten, and Cod Protein
Condition: Type 2 Diabetes; Postprandial Lipemia
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2; Hyperlipidemias
Study type: Interventional

Summary: 
      Enhanced and prolonged postprandial triglyceride responses involve increased cardiovascular
      risk in type 2 diabetes. It has been demonstrated that dietary fat and carbohydrates
      profoundly influence postprandial hypertriglyceridemia in type 2 diabetes, whereas little
      information exists about the effect of proteins.

      The purpose of this study is to compare the effects of the proteins casein, whey, cod, and
      gluten on postprandial lipid and incretin responses to a high-fat meal in type 2 diabetes.
    


Intervention name(s): Casein; Whey; Cod; Gluten
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention MeSH terms: Caseins
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Whey protein; gluten; casein; cod protein; GLP-1; postprandial; triglyceride; free fatty acids; chylomicrons; retinyl palmitate; type 2 diabetes; GIP; Postprandial incretins
PK and Safety of HCP1303 and Co-administration of HGP1201, HIP1402 Under Fed Condition in Healthy Male Volunteers
Condition: Erectile Dysfunction; Prostatic Hyperplasia
MeSH terms: Erectile Dysfunction; Prostatic Hyperplasia; Hyperplasia
Study type: Interventional
Phase: Phase 1

Summary: 
      To investigate the pharmacokinetic properties and safety after administration of HCP1303 and
      co-administration of HGP1201, HIP1402 under Fed Condition in healthy male volunteers
    

Detailed description: 
      The purpose of this study is to investigate the Pharmacokinetic Properties and Safety after
      administration of HCP1303 capsule and Co-administration of HGP1201 tablet, HIP1402 capsule
      under Fed Condition in Healthy Male Volunteers
    

Intervention name(s): HCP1303; HGP1201; HIP1402
Intervention type(s): Drug; Drug; Drug
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Cross-Cultural Use of Performance-Based Functional Assessment in Alzheimer's Disease
Condition: Mild Cognitive Impairment; Healthy Controls
MeSH terms: Alzheimer Disease; Cognitive Dysfunction
Study type: Observational

Summary: 
      This study plans to assess the effectiveness of performance-based functional assessments
      (PBFAs) and cognitive assessments in diagnosing Alzheimer's disease in Hispanic/Latino
      populations. The information from this study will be analyzed with data from the Rocky
      Mountain Alzheimer's Disease Center Bio-AD study (NCT02612376).
    


Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Participants with Mild Cognitive Impairment and healthy aging adults
Developing and Pre-Testing an eHealth Group Intervention for Young Adult Cancer Survivors
Condition: Cancer
Study type: Interventional

Summary: 
      The purpose of this study is to develop and pre-test an eHealth group intervention for young
      adult cancer survivors.
    

Detailed description: 
      In the first part of this study, the investigators adapted an evidence-based intervention for
      improving HRQOL to better meet the needs of young adult cancer survivors, and then conducted
      focus groups with young adult cancer survivors to get feedback on the adapted intervention.
      In the second part of the study, the investigators will conduct a single-arm pilot trial in
      which the adapted intervention will be delivered over videoconference via weekly group
      meetings with a trained facilitator over the course of 10 weeks.
    

Intervention name(s): Cognitive-Behavioral Stress Management and Health Education
Intervention type(s): Behavioral
Intervention description(s): Participants will attend group sessions with a trained facilitator held over videoconference. Sessions will each last 2 hours and will be held once weekly for 10 weeks. Sessions will include Cognitive-Behavioral Stress Management and health education content.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Phase IIa Study of WBI-1001 Cream for Atopic Dermatitis
Condition: Dermatitis, Atopic
MeSH terms: Dermatitis, Atopic; Dermatitis
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      WBI-1001 is a synthetic,new, non-steroid, small molecule being developed as a candidate drug
      for the topical, cream treatment of inflammatory skin diseases. As such, it affects T-cells
      through inhibition of T-cell activities including their infiltration processes, and it shows
      direct anti-inflammatory manifestation in the mouse edema model. This was a 28 day study
      (plus one follow-up week) on patients with Atopic Dermatitis, and 36 patients were treated
      randomly, BID with either 0.5%, 1.0% or placebo. Blood samples were taken weekly for PK
      analysis.
    

Detailed description: 
      A double-blind, single-centered, vehicle-controlled, randomized Phase IIa study of WBI-1001
      on patients with mild to moderate Atopic Dermatitis (AD). All body areas were treatable
      except face, scalp, groin and genital areas. Cream applied BID between 6.00 and 10.00am and
      7.00 and 10.00pm daily for 4 weeks. Blood draws for PK analysis were taken weekly at the
      study centre prior to the morning cream application. Patients returned to the study centre
      approximately one week later for a follow-up visit.
    

Intervention name(s): WBI-1001
Intervention type(s): Drug
Intervention description(s): Doses of 0,0.5% and 1.0% cream. Topical cream application. Twice daily for 28 days. Duration of treatment: 28 days with one week follow-up.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Non-steroid; Small molecule; Topical cream; Inflammatory disease; Skin
Efficacy of Cognitive Behavioral to Hypnotherapeutic Treatment of Depression
Condition: Major Depressive Disorder
MeSH terms: Depression; Depressive Disorder; Depressive Disorder, Major
Study type: Interventional

Summary: 
      The purpose of the study is to compare the efficacy of an Hypnotherapeutic Treatment of
      Depression to Cognitive Behavioral Treatment of Depression in patients with mild to moderate
      Major Depressive Episodes.
    

Detailed description: 
      Cognitive Behavioral Therapy (CBT) is considered to be an effective psychological treatment
      of mild to moderate Major Depressive Episodes. Effective treatments, however, show a
      reduction of depressive symptoms only up to 50 % (Luty et al., 2007) which is one reason for
      the modification of the well-established CBT in the last years. Following the 'third wave'
      approaches of CBT, e.g. Emotion-Focussed Therapy or Mindfulness-Based Cognitive Therapy,
      techniques like meditation or the use of systemic or Gestalt techniques within CBT has been
      applied. Within this context, Hypnotherapy-based strategies can also show an improvement of
      the current state of the art in depression psychotherapy. However, only few studies conducted
      randomised controlled trials to study the efficacy of hypnosis for depression as e.g. the
      comparison of cognitive hypnotherapy to CBT-alone (e.g. Alladin and Alibhai, 2007). With the
      present study, the efficacy of the Hypnotherapeutic Treatment of Depression (HDT) will be
      compared to the CBT-based Activation-focussed Cognitive Treatment of Depression (ACDT). Both
      treatments are individually administered and includes 20 sessions. We expect HDT not being
      inferior to ACDT in the reduction of depressive symptoms after six months of treatment.
    

Intervention name(s): HDT; ACDT
Intervention type(s): Behavioral; Behavioral
Intervention description(s): 20 sessions, individual psychotherapy; 20 sessions, individual psychotherapy
Other intervention name(s): Hypnotherapeutic Treatment of Depression; Cognitive Behavioral Therapy (CBT) of Depression
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Hypnotherapy; Cognitive Behavioral Therapy; Efficacy
Safety, Tolerability and Immunogenicity of 4CMenB Vaccine(2 Doses) in Adults With an Immunodeficiency
Condition: Acquired Immunodeficiency
MeSH terms: Immunologic Deficiency Syndromes
Study type: Observational

Summary: 
      The meningococcal quadrivalent conjugate vaccine (MenACWY) and the licenced multicomponent
      MenB vaccine (Bexsero®) have already been included in the Italian childhood immunization
      programme and recommendations for high risk categories have been also implemented.

      As by NIP, vaccination against MenB with either 4CMenB or fHbp-MenB is offered for free for
      several conditions including subjects with severe primary or secondary immunodeficiency.

      In Liguria Region meningococcal vaccination is actively offered to several chronic conditions
      including asplenia, patients with lymphoproliferative disease (also HSCT), subject treated
      with anti-CD20 mAb and HIV-positive.

      In Liguria Region there is a large diverse population with risk condition that, as by
      national and regional recommendation, receive meningococcal vaccination. For some of them,
      i.e. asplenic and complement deficiencies groups, evidence have been generated through an ad
      hoc clinical trial, while for other important groups there is clear need of immunogenicity
      data.

      In the proposed study, the Investigators plan to administer two doses of MenB vaccine
      (Bexsero®), 1-2 months apart, to adult patients living in Genoa area and belonging to
      following categories:

        -  Bone marrow transplant (HSCT patient)

        -  HIV positive

        -  Alfa-CD20 subjects (i.e. Patients candidates for / in treatment with biologic drugs such
           as Rituximab).

      Immunogenicity data will be then obtained from sera collected at the day of the first Bexsero
      dose and one month after the immunization course by Serum Bactericidal Activity (SBA) assay.
    


Intervention name(s): 4CMenB (Bexsero®) vaccine
Intervention type(s): Biological
Intervention description(s): Participants will receive 2 doses of 4CMenB (Bexsero®) vaccine administered intramuscularly 1-2 months apart
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Subjects aged 18 to 65 years with an acquired immune deficiency, including three study
        groups:

          -  Cohort l-Hematopoietic Stem Celi Transplant (HSCT) patients

          -  Cohort 2-HIV infected subjects

          -  Cohort 3-patients candidates for / in treatment with biological drugs such as
             monoclonal antibodies anti CD-20 (rituximab or ocrelizumab)
ThErapy Adherence Management in Veterans
Condition: Obstructive Sleep Apnea of Adult
MeSH terms: Sleep Apnea, Obstructive
Study type: Interventional

Summary: 
      The study is a prospective, randomized, controlled trial studying adherence to positive
      airway pressure therapy in a population referred to the VA system for the treatment of sleep
      disordered breathing. The primary aim of the study is to determine if, compared to standard
      care provided at a VA Sleep Center, the deployment of a structured adherence management
      program and a web-based information program designed for participants beginning positive
      airway pressure therapy results in a greater portion of participants meeting Centers for
      Medicare & Medicaid Services (CMS) adherence requirements (use > 4 hours for >= 70% of days)
      at 90 days.
    

Detailed description: 
      The primary aim of the study is to determine if, compared to standard care provided at a VA
      Sleep Center, the deployment of a structured adherence management program and a web-based
      information program designed for participants beginning positive airway pressure therapy
      results in a greater portion of participants meeting CMS adherence requirements (use > 4hrs
      on >=70% of nights) at 90 days.

      Secondary aims:

        1. Results in higher nightly use of therapy (hours per night and % of nights with at least
           4 hours of use) at 90 days

        2. Results in participant satisfaction that is superior to current standard care

        3. Offers operational efficiencies or economic benefits to the health care facility
           (reduced staff time (sleep clinic and physician), equipment consumption, unplanned
           participant contacts or visits, and reduced overtime)

        4. Results in indirect benefits to participants (fewer clinic visits, less travel or
           in-clinic/ office visit waiting time)
    

Intervention name(s): structured adherence management program; Standard of care
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Structured adherence management service (PAMS) program and a web-based information program designed for participants beginning positive airway pressure therapy; Standard care provided at a VA Sleep Center for participants beginning positive airway pressure therapy
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: After undergoing screening and enrollment, participants will be assigned to either standard care follow-up or to the patient adherence monitoring service (PAMS).
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
A Clinical Evaluation of the Next Generation Diagnostic Instrument (NGDI)
Condition: Healthy
Study type: Interventional

Summary: 
      The purpose of this study is to measure the aberrations, corneal surface topography and
      pachymetry of normal human eyes with the NGDI.
    


Intervention name(s): Next Generation Diagnostic Instrument (NGDI); Zyoptix Diagnostic Workstation (ZDW)
Intervention type(s): Device; Device
Intervention description(s): Measurement of the aberrations, corneal surface topography, and pachymetry of normal human eyes; Measurement of the aberrations, corneal surface topography, and pachymetry of normal human eyes
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Corneal surface topography; Ocular aberrations
OHRQoL and Accelerated Orthodontics With Micro-osteoperforations
Condition: Malocclusion
MeSH terms: Malocclusion
Study type: Interventional

Summary: 
      OHRQoL assessment using OHIP-14 between sliding anterior retraction with self-ligating
      brackets and micro-osteoperforations for accelerated orthodontics in orthognathic surgery
      patients who were assigned for pre-molar extraction and decompensation
    

Detailed description: 
      Our patients are participants in a randomized clinical trial, an ongoing study about the
      effectiveness of micro-osteoperforations to accelerate tooth movement. The study sample
      consisted of 22 consecutive subjects - 12 females and 10 males - between the ages of 18 and
      35, who were selected for ortho-surgical treatment and pre-molar extraction assigned for
      decompensation. The participants were randomly allocated to two groups: control (anterior
      retraction was performed using implant-assisted sliding mechanics with self-ligating
      brackets) and experimental (micro-osteoperforations were performed in the activation
      appointments for anterior retraction using implant-assisted sliding mechanics). For immediate
      and follow-up assessment of patients' perceptions, comparing regular orthodontic activation
      and activation with Accelerated Orthodontics, subjects were asked to complete an electronic
      questionnaire OHIP-14, to assess the participants' comfort level, experiences, and QoL
      impact.
    

Intervention name(s): micro-osteoperforations
Intervention type(s): Procedure
Intervention description(s): Three vertical micro-osteoperforations, using Excellerator, in the buccal extracted site were executed following the aseptic procedure and local anesthesia
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Effect of Intracameral Steroids During Phacoemulsification on the Cornea
Condition: Corneal Edema
MeSH terms: Corneal Edema
Study type: Interventional
Phase: Phase 3

Summary: 
      Prospective, interventional case control study. Sixty-nine eyes were randomized into 3
      groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA)
      respectively, while controls didn't receive any intraoperative steroids.

      Intracameral steroids at the conclusion of phacoemulsification significantly improved corneal
      edema and spared corneal endothelium.
    

Detailed description: 
      Purpose: Investigating the effect of intracameral steroids at the end of phacoemulsification
      on corneal edema and endothelial count.

      Methods: Prospective, interventional case control study. Sixty-nine eyes were randomized into
      3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA)
      respectively, while controls didn't receive any intraoperative steroids.

      On the first postoperative day corneal edema in control compared to dexamethasone and TA
      groups respectively.

      One month later, the mean increase of corneal thickness in control compared to intracameral
      dexamethasone and TA groups, respectively.

      mean endothelial cell loss in control compared to intracameral dexamethasone and TA groups
      respectively.
    

Intervention name(s): Control group; Dexamethasone group; Triamcinolone (TA) group
Intervention type(s): Other; Drug; Drug
Intervention description(s): 23 eyes that didn't receive any intraoperative steroids; 23 eyes each received intracameral dexamethasone at the conclusion of phacoemulsification Received intracameral 0.4 mg in / 0.1 ml dexamethasone (8mg/2ml®; Amriya or Epico) at the end of phacoemulsification.; 23 eyes each received intracameral triamcinolone (TA) at the conclusion of phacoemulsification Received intracameral 2 mg/0.05 ml triamcinolone (TA) (Kenacort-A®; Bristol-Myers Squibb) at the end of phacoemulsification.
Other intervention name(s): No intraoperative steroids; Intracameral Dexamethasone; Intracameral triamcinolone (TA)
Intervention MeSH terms: Dexamethasone; Dexamethasone acetate; Triamcinolone; Triamcinolone Acetonide; Triamcinolone hexacetonide; BB 1101; Triamcinolone diacetate
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Purpose: Investigating the effect of intracameral steroids at the end of phacoemulsification on corneal edema and endothelial count.
Methods: Prospective, interventional case control study. Sixty-nine eyes were randomized into 3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA) respectively, while controls didn't receive any intraoperative steroids.
Masking: None (Open Label)
Primary purpose: Prevention