bioihbjkbjnl/mcl2 huggingface dataset:
Human Selenoprotein P Concentration With Glucose Tolerance Status
Condition: SEPP1 Levels in Differnet Glucose Tolerance Status
Study type: Observational

Summary: 
      Recently, seslenium(Se) has known as important regulator in metabolic status, lipid profile,
      atherosclerosis progression. SEPP1(selenoprotein P1)is a secreted protein from mainly liver.
      This protein is used as an index of selenium nutritional status. The association between the
      concentration of SEPP1(selenoprotein P1) in normal glucose tolerance,impaired glucose
      tolerance, type 2 diabetes is still a matter of debate. This cross sectional study will
      evaluate whether glucose status is matter in SEPP1 level.
    


Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Total 180 patients Normal 60-IGT 60-T2DM 60
Study to Confirm the Safety and Efficacy of Tegoprazan in Patients With Healed Erosive Reflux Disease
Condition: Erosive Reflux Disease
MeSH terms: Gastroesophageal Reflux
Study type: Interventional
Phase: Phase 4

Summary: 
      This study is designed to evaluate the efficacy and safety of Tegoprazan 50mg, compared to
      Lansoprazole 30mg in patients with healed erosive reflux disease confirmed by endoscopy
      following oral administration once daily(QD) of 2 weeks or 4 weeks.
    

Detailed description: 
      This is a double blind, radomized, active-controlled, phase 4 study. Subjects will be
      randomly assigned to one of the two treatment groups (Tegoprazan 50mg, Lansoprazole 30mg)
    

Intervention name(s): Tegoprazan 50mg QD; Lansoprazole 30mg QD
Intervention type(s): Drug; Drug
Intervention description(s): Tegoprazan 50mg tablets will be orally administered, once daily, for up to 2 weeks or 4 weeks.; Lansoprazole 30mg tablets will be orally administered, once daily, for up to 2 weeks or 4 weeks.
Intervention MeSH terms: Lansoprazole; Dexlansoprazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Effects of Insulin in Perceived Mood Symptoms in Patients With Type 2 Diabetes
Condition: Type 2 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 4

Summary: 
      This study investigates the influence of two different insulin regimens, twice-daily insulin
      lispro low mix (LM) and once-daily insulin glargine, on perceived physical, mood, and
      cognitive symptoms as well as cognitive-motor task performance in patients with type 2
      diabetes.
    


Intervention name(s): insulin lispro protamine suspension:insulin lispro rDNA origin low mix; insulin glargine
Intervention type(s): Drug; Drug
Intervention MeSH terms: Insulin; Insulin, Globin Zinc; Insulin Glargine; Insulin Lispro; Protamines
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Measuring the Effect of Chair Massage on Stress Related Symptoms for Nurses
Condition: Stress; Fatigue; Anxiety; Tension
MeSH terms: Fatigue
Study type: Interventional

Summary: 
      The purpose of this study was to assess the feasibility and effect of chair massage provided
      during working hours for nurses in an inpatient psychiatric and an outpatient pain
      rehabilitation unit and on the nurses stress related symptoms.
    

Detailed description: 
      Nursing staff working in a hospital in-patient psychiatric unit and out-patient pain
      rehabilitation/ fibromyalgia units each have varying causes of stress as both are intensely
      demanding environments. The physical and psychosocial demands of these stress-loaded work
      environments place a significant amount of strain on the physiological well-being of the
      employee.

      Nurses in these settings are considered healthy employees and able to participate in the
      workforce, although symptoms such as headaches, shoulder tension, insomnia, fatigue, and
      muscle and joint pain are often a part of their work day. As these stress related symptoms
      become more chronic, they lead to days missed and become pre-cursors to physiological
      illnesses so warrant further search for prevention tactics.

      Massage therapy has been noted to decrease levels of anxiety and fatigue which is essential
      to maintaining employee's efficient care in a dynamic environment. This study will provide
      massage in the workplace utilizing chair massage as it is easy to set up, does not need a
      great deal of space, and can be provided in semi-private areas, as the participant remains
      clothed. A 2006 report on a small study indicated chair massage can be effective in reducing
      stress perception in nurses within a hospital setting, at least in the short-term. Another
      study reported some short-term positive effects on stress related symptoms; and came to the
      conclusion that further studies are indicated to examine the efficacy of workplace-based
      massage therapy programs.
    

Intervention name(s): Chair massage
Intervention type(s): Procedure
Intervention description(s): Chair massage for 15 minutes once a week for 10 weeks.
Other intervention name(s): Massage
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Massage; Chair massage; Relaxation; Nurses
Assessment of Longitudinal Changes in Endothelial Function and Oxidative Stress in Normotensive Patients With ADPKD
Condition: Autosomal Dominant Polycystic Kidney Disease
MeSH terms: Kidney Diseases; Polycystic Kidney Diseases; Polycystic Kidney, Autosomal Dominant
Study type: Observational

Summary: 
      The purpose of this study is to determine whether patients with autosomal dominant polycystic
      kidney disease (ADPKD) present with abnormal endothelial function, increased levels of NOX4
      activity and mitochondrial abnormalities, contributing to oxidative stress from early stages
      that correlate with disease severity.
    

Detailed description: 
      Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic and the
      fourth cause of end-stage renal disease (ESRD) in adults worldwide. Cardiovascular diseases
      are the most important non-cystic complications and continue to be the leading cause of
      premature mortality in these patients. Hypertension (HTN) is present in approximately 50% of
      the patients at early stages, and increases to nearly 100% at ESRD. Furthermore, HTN
      contributes to the underlying renal disease progression. Nitric oxide (NO) associated
      endothelium-dependent vasorelaxation has been shown to be impaired in small subcutaneous
      resistance vessels from patients with ADPKD before the development of HTN. However, the
      principal contributors to vascular dysfunction remain unclear.

      The investigators broad objective is to evaluate the presence and extent of endothelial
      dysfunction and its association with oxidative stress in young normotensive patients with
      ADPKD, with the long term goal of timely intervention to slow the progression of the disease
      in these patients.

      Participants in this study will have their endothelial function assessed using a non-invasive
      technique, peripheral arterial tonometry (PAT), which has been shown to be a useful, highly
      reproducible, and non-operator dependent method for non-invasive assessment of vascular
      health. The investigators will assess longitudinal changes in endothelial function using PAT
      with the intention of establishing if this methodology offers the potential of non-invasive
      measures of early vascular disease in young normotensive patients with ADPKD. Biochemical
      markers of endothelial dysfunction will be assessed concomitantly. In addition, the
      investigators will assess oxidative stress levels in these patients, with the intention of
      determining the association with endothelial dysfunction.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Male and female patients with a previous diagnosis of ADPKD that meet the inclusion
        criteria. In addition, patients will be matched 2:1 to age and gender healthy controls.
        Exclusion criteria are listed in for ADPKD patients and healthy controls.
      
Keywords: ADPKD; Endothelial dysfunction; Oxidative stress; NADPH oxidase 4 (NOX4); Mitochondria
Effect of Premature Luteinization on the Oocyte Quality in Oocyte Donation Program.
Condition: Premature Luteinization
MeSH terms: Premature Birth
Study type: Observational

Summary: 
      Analyze the possible effect of the progesterone levels of the hCG administration on the
      oocyte embryo quality. The primary endpoint of this study is the pregnancy rate.
    


Observational model: Defined Population
Time perspective: Prospective
Effectiveness of Computerized Cognitive Training in the Elderly With Cognitive Impairment
Condition: Mild Cognitive Impairment
MeSH terms: Cognitive Dysfunction
Study type: Interventional

Summary: 
      This study is to investigate the effectiveness of computerized cognitive training, and
      corresponding neural substrates through multimodal neuroimaging assessment, in the elderly
      with normal cognition, subjective cognitive impairment, and mild cognitive impairment.
    

Detailed description: 
      Computerized cognitive training has the advantage of easy accessibility for
      community-dwelling elderly. It can be much cheaper than traditional neuropsychological
      training methods, which require trained neuropsychologists. Furthermore, it may be more fun
      and easier to be optimized to an individual patients' cognitive status than other traditional
      methods.

      Clinical efficacy of these kinds of cognitive training applications has been validated
      through several studies. A recent systematic review reported that the domains of working
      memory, executive function, and processing speed benefited the most by classic computerized
      cognitive training tasks, and that these benefits were comparable with traditional cognitive
      training methods. Apart from neuropsychological data, neuroimaging studies focusing on the
      effectiveness of computerized cognitive training are scant.

      There have been no previous studies investigating the possible neural substrates of
      computerized cognitive training using multimodal neuroimaging modalities simultaneously.
      Thus, we aimed to investigate the effectiveness of computerized cognitive training and
      corresponding neural substrates in subjects with mild cognitive impairment, subjective memory
      impairment, and normal controls through a multimodal approach.
    

Intervention name(s): Computerized Cognitive Training Apparatus
Intervention type(s): Behavioral
Intervention description(s): CoCoTA was developed through collaborative research with the Korean Institute of Science and Technology (KIST) and Primpo Co. Ltd. (www.primpo.com). It was designed to stimulate numerous cognitive domains simultaneously by using sounds and objects familiar to Korean elderly. Training themes and scenarios were developed and evaluated by six board-certified neurologists and three neuropsychologists who specialize in dementia.
Each subject participated in a total of 24 sessions of cognitive training, which consisted of 40 minutes of training, twice per week. To assure the consistency of cognitive training, trained personnel stayed nearby the subjects to help throughout the training process.
Other intervention name(s): CoCoTA
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: subjective cognitive impairment
Propolis Versus Calcium Hydroxide on Post-Operative Pain in Patients With Necrotic Pulp
Condition: Post-Operative Pain, Chronic; Necrotic Pulp
MeSH terms: Dental Pulp Necrosis; Pain, Postoperative; Chronic Pain; Necrosis
Study type: Interventional

Summary: 
      Propolis is a resinous product of honeybees. Propolis is said to be effective against
      resistant microorganisms inside the root canal compared to the gold standard medication known
      as calcium hydroxide. The clinical trial tests the effect of propolis versus calcium
      hydroxide on pain in patients with necrotic teeth.
    

Detailed description: 
      Propolis is an immunomodulatory, antioxidant, flavonoid-rich resinous product of honeybees.
      Propolis was reported as less cytotoxic and more effective against resistant microorganisms
      than calcium hydroxide as well as biocompatible to the periradicular tissues than existing
      intracanal medicaments. The aim of this single-blinded randomized clinical trial was to
      evaluate the effect of propolis versus calcium hydroxide, intracanal medicaments, on
      post-operative pain in patients with necrotic single canal teeth. Methods: Forty-six
      participants with an age range of 20-40 years old, diagnosed as having necrotic pulp in their
      single-rooted, single canal teeth were included in this study, with 23 participants in each
      group. Treatment was done in two visits and intracanal medicament was applied for one week in
      between. Participants were instructed to rate their pain score by a numerical rating scale
      after 24, 48, 72 hours and at 7 days.
    

Intervention name(s): propolis; Calcium Hydroxide
Intervention type(s): Dietary Supplement; Drug
Intervention description(s): resinous product of honeybees; Gold standard control intracanal medicament
Intervention MeSH terms: Propolis; Calcium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Diagnostic
Keywords: calcium hydroxide; propolis; post-operative pain; necrotic pulp
Clinical Investigation on the Efficacy and Safety of Relizema Cream in Paedriatric Patients
Condition: Atopic Dermatitis
MeSH terms: Dermatitis, Atopic; Dermatitis; Eczema
Study type: Interventional

Summary: 
      The scope of this multicenter, double blind, randomized, vehicle-controlled clinical
      investigation is to evaluate and confirm the performance and safety of the Relizema cream in
      the improvement of the dermatitis severity in paediatric patients. The disease severity will
      be clinically measured through the Investigator Global Assessment (IGA) after 42 days of
      treatment.
    

Detailed description: 
      This is a Pre Market Study to evaluate and confirm the performance of the RelizemaTM cream in
      the improvement of the dermatitis severity, assessed through a clinical parameter, the
      Investigator's Global Assessment (IGA) at baseline and at Visit 3, compared to vehicle.

      To evaluate the performance of the RelizemaTM cream, compared to placebo in the eczema
      improvement through the EASI.

      The safety objectives is to evaluate the local and general tolerability of Relizema cream
      compared to placebo.
    

Intervention name(s): Relizema cram
Intervention type(s): Device
Intervention description(s): Relizema cream is a CE marked, Class IIa medical device, dermatological cream for topical use indicated for symptomatic treatment of dermatitis and erythema. Relizema cream is indicated for the treatment of itching and flushing associated with different types of dermatitis, including atopic dermatitis.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: multicenter, double blind, controlled versus placebo, pre-market clinical followup investigation
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: cream; paediatric patients
Anticipatory Muscle Control and Effect of Stabilizing Exercises in Patients With Subacute and Chronic Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      Muscular stability is essential to the spinal column to avoid harmful strain and injury to
      its structures. Sudden postural disturbances impose reactive internal forces through the
      spine. If the muscles do not react before the internal reactive forces propagate through the
      spine, there is a short fraction of time where the spinal column may lack sufficient muscular
      support. Studies have shown that in patients with low back pain deep abdominal and back
      muscle have a delayed response to reactive forces. The purpose of this study is to verify
      these findings and to investigate whether tailored interventions can improve the reaction
      time in stabilizing muscle around the lower spinal column i patients with subacute and
      chronic low back pain.
    


Intervention name(s): Isolated Transversus abdominis (TrA) exercise; sling exercise; group exercise
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Eight weeks Isolated Transversus abdominis (TrA) exercise(low load) program; Isolated TrA control through biofeedback; Eight weeks sling(high load) exercise program; Isolated TrA control through biofeedback; Eight weeks non-specific group exercise program; Isolated TrA control through biofeedback
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Muscle, Skeletal; Neuromuscular control; Stability; Exercise; Anticipatory muscle control
Effects of High-intensity Interval Training on Myocardial Strain in Metabolic Syndrome Patients
Condition: High-Intensity Interval Training; Metabolic Syndrome; Myocardial Dysfunction
MeSH terms: Metabolic Syndrome; Syndrome
Study type: Interventional

Summary: 
      the effects of high-intensity interval training on myocardial function will be studied in a
      group of patients under medical treatment for the components of metabolic syndrome.
    

Detailed description: 
      Objective: To analyze the effects of high-intensity interval training (HIIT) on myocardial
      function of metabolic syndrome patients.

      Methods and design. Randomized clinical trial with a control group. Project was developed in
      association with the regional general hospital. Pre and post-intervention evaluation after 16
      weeks of training for the HIIT group.

      Subjects: Recruited using adverts published on public medical center boards. Up to 30
      subjects per group (HIIT and CONTROL) will be recruited (at least 20% women) Measurements.
      Echocardiography: Global longitudinal strain (GLS), Mitral filling parameters, myocardial
      dimensions, and myocardial wall thickness.

      Cardiorespiratory fitness: Maximal oxygen consumption, Maximal power output, Maximal oxygen
      pulse.

      Clinical: Metabolic syndrome components and derived variables (e.g.,
      triglycerides/high-density lipoprotein ratio) Body composition by anthropometric measurements
      and dual-energy X-ray absorptiometry.
    

Intervention name(s): High-intensity interval training
Intervention type(s): Behavioral
Intervention description(s): supervised exercise conducted on stationary bikes after individualized intensity prescription.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized clinical trial with control group
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Levothyroxine Treatment in Thyroid Benign Nodular Goiter
Condition: Thyroid Nodule
MeSH terms: Thyroid Nodule; Thyroid Diseases; Goiter, Nodular
Study type: Interventional

Summary: 
      We will study the effect of taking eltroxin at different time, i.e. fasting or postprandial
      periods. We will also study the effect of levothyroxin treatment in Chinese people
    

Detailed description: 
      OBJECTIVE - Current treatment of benign thyroid is oral levothyroxin by suppression of
      thyrotropin secretion and so that tumor growth. Although current consensus is taking thyroxin
      one hour before meal because the PH value of gastrointestinal tract will affect drug
      absorption, some patient suffered from epigastric discomfort when taking thyroxin with empty
      stomach, and wish to take it postprandial. However, there is no direct evidence showing if
      taking thyroxin at different time point significantly affects treatment outcome. Besides, the
      response to thyroxin therapy differs among people. The purposes of this study are to evaluate
      the clinical significance of different time points of thyroxine intake and to search factors
      relating to thyroxin response of benign thyroid tumors.

      RESEARCH DESIGN AND METHODS - We will include patients who have benign thyroid tumors
      diagnosed with fine needle aspiration cytology and have normal thyroid function into our
      study. After informed consent, patients will be randomly assigned into two groups. Patients
      in the first group will take thyroxin one hour before breakfast until thyrotropin level
      stabilized between 0.5 and 1.0 mU/L for 3 months. Then thyroxin will be discontinued.
      Patients will restart thyroxin therapy three months later but after breakfast. Patients in
      another group will take thyroxin postprandial, discontinue thyroxin and then one hour before
      breakfast. Questionnaire interviews about diet and life style, blood samples and fine needle
      aspiration cytology samples will be obtained. Changes of thyroid nodules will be evaluated
      with thyroid echo.

      STATISTIC ANALYSIS - Descriptive data will be described as means and SDs for continuous
      variables, and analysis of variance and Chi-square tests were used for assessing the
      significances. A p-value below 0.05 was considered significant.

      Keywords: benign thyroid tumor, thyroxin, preprandial, postprandial.
    

Intervention name(s): Levothyroxin treatment
Intervention type(s): Drug
Intervention description(s): Levothyroxin 100 micogram will be administered once daily 1 hour before meal of just after meal for 3 months, and the dose will be titrate to keep serum TSH level between 0.1~0.3 mU/L. It will be discontinued for 3 months. Then
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Safety and PK Study of MP-424 to Treat Chronic Hepatitis C
Condition: Chronic Hepatitis C
MeSH terms: Hepatitis A; Hepatitis C; Hepatitis C, Chronic; Hepatitis; Hepatitis, Chronic
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to assess the safety, pharmacokinetics and HCV(Hepatitis C
      virus) RNA (Ribonucleic Acid) kinetics after administration of MP-424 to patients with
      chronic hepatitis C.
    


Intervention name(s): MP-424 (Telaprevir)
Intervention type(s): Drug
Intervention description(s): Three tablets of MP-424 250mg tablet at a time, every 8 hours, 12 weeks administration (dose in a day: 2250 mg)
Intervention model: Single Group Assignment
Masking: None (Open Label)
Keywords: Chronic Hepatitis C; Protease Inhibitor