bioihbjkbjnl/mcl2 huggingface dataset:
Nourishing Hair, Skin & Nails Supplement Study (Derm Aid)
Condition: Hair Loss; Skin Laxity; Cosmetic Acne; Nails; Soft; Skin Aging
MeSH terms: Cutis Laxa; Alopecia
Study type: Interventional
Phase: Phase 3

Summary: 
      A 90 day eight arm virtual interventional study looking at the impact of various supplement
      formulations for improves in hair, skin & nail health via self report, and dermatology
      assessment via remote dermatologist assessment.
    

Detailed description: 
      This study is being run entirely on the ProofPilot clinical trial platform. Participants
      enroll online, submit selfies, and are shipped dietary various dietary supplements containing
      a one or more of Keratin, Astaxanthin, Collagen Peptides and Pro-berry powder in vegan and
      non-vegan formats. All participants will receive active ingredients but in various
      fomulations.

      Half the participants will receive the formations for free. The other half will pay a
      discounted amount for the supplements.
    

Intervention name(s): Vegetarian Collagen; Keratin; Ceramides; Astaxanthin
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Collagen is a protein made up of amino-acids, which are in turn built of carbon, oxygen and hydrogen.; Keratin (/ˈkɛrətɪn/) is one of a family of fibrous structural proteins known as scleroproteins. α-Keratin is a type of keratin found in vertebrates. It is the key structural material making up hair, nails, feathers, horns, claws, hooves, calluses, and the outer layer of skin among vertebrates.; Ceramides are a family of waxy lipid molecules. A ceramide is composed of sphingosine and a fatty acid. Ceramides are found in high concentrations within the cell membrane of eukaryotic cells, since they are component lipids that make up sphingomyelin, one of the major lipids in the lipid bilayer.; is a naturally-occurring carotenoid found in algae, shrimp, lobster, crab and salmon.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants are randomized into one of eight arms. The arms include four combinations of dietary supplements for skin, hair & nail health (Keratin, collagen peptides, pro-berry powder, vegan Keratin, and Astaxanthin). Each supplement formation is included in two arms - one arm is paid, the other arm is free.
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Bioequivalence of Rebamipide in Korean
Condition: Therapeutic Equivalency; Pharmacogenetics
Study type: Interventional

Summary: 
      The aims of this study were to evaluate the pharmacokinetic properties and bioequivalence of
      two rebamipide preparations in healthy Korean male volunteers for generic substitution and to
      evaluate the association between the genetic polymorphisms in ABCB1 gene (exon 21 and 26) and
      rebamipide disposition.
    

Detailed description: 
      A randomized, single-dose, 2-period crossover design with a 7-day washout period was
      conducted in 30 healthy Korean male volunteers. Subjects were randomly assigned to receive a
      single 100-mg dose of the test or reference preparation of rebamipide, administered with 240
      mL of water after a 12-hour overnight fast. All subjects were selected after passing a
      clinical screening procedure that included a physical examination and laboratory tests. Serum
      concentrations of rebamipide up to 12 hours after administration were determined using a
      validated HPLC method with fluorescence detection. Adverse events (AEs) were continuously
      monitored by clinical staff via observation, personal interview, and vital signs
      (temperature, blood pressure, heart rate) during the study period. All adverse events were
      recorded on the clinical record form per subject up to 1 week after the study.
      Pharmacokinetic parameters were determined using a noncompartmental method. The preparations
      were considered bioequivalent if the log-transformed ratios of AUC0-t, AUC0-∞, and Cmax were
      within the predetermined bioequivalence range (ie, 80-125%), as set by the US Food and Drug
      Administration (FDA) and Korean legislation. In vitro dissolution profiles of both
      preparations were examined and the influence of genetic polymorphisms in ABCB1 gene
      (P-glycoprotein) on the pharmacokinetics of rebamipide was also investigated.
    

Intervention name(s): Rebamide
Intervention type(s): Drug
Intervention description(s): Rebamipide 100 mg Tablet, three times a day
Other intervention name(s): Mucosta® (Korea Otsuka Pharmaceuticals Co.)
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Rebamipide; Bioequivalence; ABCB1 genetic polymorphisms
A Prospective, Multicentre, Open-label Randomised Controlled Study to Investigate the Effectiveness of Pamidronate in the Prevention of Bone Loss in de Novo Renal Transplant Patients.
Condition: Bone Loss
MeSH terms: Bone Diseases, Metabolic
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of the study was to evaluate the effect of Pamidronate on bone mineral density
      loss and fracture rates up to 2 years, in post renal-transplant subjects on a Ciclosporin A
      and glucocorticoid based immunosuppressive regimen.
    


Intervention name(s): Pamidronate
Intervention type(s): Drug
Intervention MeSH terms: Pamidronate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Renal; transplant,; pamidronate,; ciclosporin,; Ciclosporin A,; steroids,; bone mineral density,; fracture rates; immunosuppressive; regimen
Early Versus Delayed Pneumococcal Vaccination in HIV
Condition: Pneumococcal Infections
MeSH terms: Pneumococcal Infections
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The purpose of this study is to determine whether people who are HIV-positive respond better
      to a vaccine for pneumonia-related disease when they are immunized immediately, or when
      immunization is delayed until the immune system has improved to a certain level. The study
      will also compare the effectiveness of polysaccharide and heptavalent vaccines.
    

Detailed description: 
      A multicentre, randomized controlled trial using a two factorial design. Eighty patients will
      be randomly assigned to receive either Pneumovax (or Pneumo23 according to standard use at
      site) or heptavalent pneumococcal conjugate vaccine (Prevnar) prior to reconstitution of the
      immune system or will have immunization delayed until their CD4 count is greater than 200
      cells/mm3 after the introduction of antiretroviral therapy. Randomization will be stratified
      by study centre. Variable block sizes will be used to try to prevent study personnel from
      guessing the next allocation. Random allocation lists will be generated by computer.
    

Intervention name(s): Pneumovax; Prevnar
Intervention type(s): Biological; Biological
Intervention MeSH terms: Heptavalent Pneumococcal Conjugate Vaccine
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: HIV; HIV Infections
The Effects of Dry Needling & Kinesio Tape on Anterior Knee Pain
Condition: Patellofemoral Pain Syndrome
MeSH terms: Patellofemoral Pain Syndrome
Study type: Interventional

Summary: 
      Patellofemoral Pain Syndrome(PFPS) is one of the most common health-related complaints in
      today's societies. Myofascial pain syndrome(MPS) have been attributed as the main cause and
      primary source of musculoskeletal pain. Trigger point of the vastus lateralis muscle may pull
      the patella superiorly and laterally, increasing compression of the patellofemoral joint
      during physical activities, result in PFPS and anterior knee pain. The purpose of this study
      was to investigate the effects of Dry Needling & kinesio tape on trigger point of vastus
      lateralis muscle in PFPS subjects.
    

Detailed description: 
      Pain intensity, pain pressure threshold and Disability of knee were collected at base line
      and at the end of treatment sessions.
    

Intervention name(s): Dry Needling; Kinesio Tape
Intervention type(s): Device; Device
Intervention description(s): Dry needling was performed for one week, three times a week.; Kinesio tape was performed for one week, three times a week.
Other intervention name(s): Western Accupuncture; Kenso Tape
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Knee pain,Dry Needling, kinesioTape,Trigger point
Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid Arthritis
Condition: Juvenile Rheumatoid Arthritis
MeSH terms: Arthritis; Arthritis, Rheumatoid; Arthritis, Juvenile
Study type: Interventional
Phase: Phase 3

Summary: 
      To evaluate efficacy, safety and pharmacokinetics of adalimumab in Japanese children with
      Polyarticular Juvenile Rheumatoid Arthritis
    

Detailed description: 
      This was an open-label long-term study that was completed following study drug approval in
      Japan for the treatment of JRA. Data are presented through Week 144 and for the final visit.
    

Intervention name(s): Adalimumab
Intervention type(s): Biological
Intervention description(s): Adalimumab administered subcutaneously every other week, with dosage determined by body weight at study entry (20 mg for children weighing less than 30 kg, 40 mg for children weighing 30 kg or more).
Other intervention name(s): adalimumab, ABT-D2E7, Humira
Intervention MeSH terms: Adalimumab
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Juvenile Rheumatoid Arthritis
Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus
Condition: Oral Lichen Planus
MeSH terms: Lichen Planus, Oral; Lichen Planus
Study type: Observational

Summary: 
      60 individuals were subdivided into 2 groups, 30 patients with oral lichen planus, 30 control
      individuals. Expression of miRNA-138 and cyclin D1 were evaluated in oral mucosa utilizing
      Quantitative real-time polymerase chain reaction and immunohistochemistry.
    

Detailed description: 
      60 individuals were subdivided into 3 groups, into 2 groups, 30 patients with oral lichen
      planus, 30 control individuals having age, gender and periodontal status matched with both
      patients groups acting as a control group. Relative gene expression of miRNA-138 was
      estimated using Quantitative real-time polymerase chain reaction technique in oral mucosa of
      both oral lichen planus patients and control subjects. Sub grouping of oral lichen planus
      patients were performed into reticular, atrophic and erosive groups (n=10 each). Cyclin D1
      gene expression was estimated using Quantitative real-time polymerase chain reaction
      technique and Cyclin D1 protein level was estimated using immunohistochemistry.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        60 individuals were subdivided into 2 groups, 30 patients suffering from oral lichen planus
        and 30 individuals having age, gender and periodontal status matched with both patients
        groups acting as a control group.
      
Biospecimen description: 
      oral mucosa tissue specimen
Efficacy Study of an Investigational Influenza Vaccine (Vero Cell Derived) to Prevent Culture Confirmed Influenza Infection (CCII)
Condition: Influenza
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 3

Summary: 
      The primary purpose of this study is to demonstrate the efficacy of an investigational
      Vero-cell derived influenza vaccine to prevent infection in an adult population with an
      influenza virus that is antigenically similar to one of the three strains in the vaccine. All
      subjects will be randomized to receive a single 0.5 ml intramuscular injection from one of
      three lots of seasonal Vero-cell derived influenza vaccine or saline placebo. Subjects will
      be monitored for 180 days following vaccination for occurrence of adverse events. For
      determining antibody response, subjects will have one blood draw before and one blood draw 21
      days after vaccination.
    


Intervention name(s): Inactivated seasonal influenza vaccine (split virus, Vero cell-derived); Phosphate buffered saline
Intervention type(s): Biological; Other
Intervention description(s): Trivalent, non-adjuvanted vaccine; dose: 0.5 ml; Packaged in syringes identical to those used for the investigational vaccine; dose: 0.5 ml
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
The Effect of Scent on Pregnancy Induced Nausea, Vomiting, and Quality of Life
Condition: Morning Sickness; Pregnancy Early
MeSH terms: Morning Sickness; Vomiting
Study type: Interventional

Summary: 
      This study evaluates the effects of essential oils on nausea, vomiting, and quality of life
      scores among pregnant women. Participants will receive either an essential oil roll-on
      product or a placebo product to apply to their temples and jaw line daily for 6 days.
    

Detailed description: 
      The inhalation of certain essential oils has been found to reduce feelings of nausea and to
      improve quality of life during pregnancy.

      The essential oils used in this study are applied topically to the temples and jaw line every
      4-6 waking hours over a 6-day period. Each application will produce an exposure that lasts up
      to 30-45 minutes before fading. At the end of each day, nausea and vomiting levels will be
      assessed using a validated measurement instrument.

      Quality of life is measured using a 30-question tool that measures both pregnancy-related
      quality of life and pregnancy-induced nausea and vomiting.
    

Intervention name(s): Citrus-Based Aromatherapy; Mint-Based Aromatherapy; Spice-Scented Aromatherapy; Control
Intervention type(s): Other; Other; Other; Other
Intervention description(s): This intervention is a blend of plant derived oils which have been distilled from crude plant matter and analyzed in a laboratory to identify chemical composition.; This intervention is a blend of plant derived oils which have been distilled from crude plant matter and analyzed in a laboratory to identify chemical composition.; This intervention is a blend of plant derived oils which have been distilled from crude plant matter and analyzed in a laboratory to identify chemical composition.; This control is a blend of plant derived oils which have been expressed from crude plant matter.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Keywords: Aromatherapy; Essential Oils
Brain Computer Interface Control of a Robotic Device
Condition: Healthy
Study type: Observational

Summary: 
      Noninvasive Brain-Computer Interfaces (BCIs) have been used to control a number of virtual
      and physical objects through the voluntary modulation of brain rhythms. Current issues with
      noninvasive BCIs include exhausting motor imagery tasks and long training times required to
      achieve competent control. The investigators will address these issues within this protocol,
      examining new approaches to reduce the effort required by subjects to control a physical
      object in the task.

      The PI's hypothesis is: Control of a physical robotic device will increase the performance of
      subjects in BCI tasks that are analogous to virtual tasks due to greater engagement with a
      physical output.
    

Detailed description: 
      Subjects will be recruited to participate in controlling a physical robotic device such as a
      quadcopter or a robotic arm using imagination of movement or other activities as detected by
      brain waves that can be used to control a robotic device.

      The subjects will be able to observe the controlling of a robotics device using one's thought
      and participate in multiple sessions to learn the skills to better control such a device.
    

Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Healthy subjects, primarily from individuals on the University of Minnesota Campus and
        Minneapolis area
      
Keywords: Subjects
Safety, Tolerability and Pharmacokinetics of KUC 7483 CL Tablets in Healthy Male Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      Study to investigate safety, tolerability and pharmacokinetics of KUC 7483 CL after repeated
      dosing
    


Intervention name(s): KUC 7483 CL; Placebo
Intervention type(s): Drug; Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Zinc & Bone Health in Thalassemia: The Think Zinc Study
Condition: Thalassemia
MeSH terms: Thalassemia
Study type: Interventional

Summary: 
      The purpose of this study is to test whether zinc can improve bone health in young patients
      with thalassemia.
    

Detailed description: 
      The primary aim of this study is to determine if zinc supplementation improves bone health in
      young patients with thalassemia. Osteoporosis is a significant co-morbidity in patients with
      thalassemia which leads to decreased quality of life. The most effective way to prevent
      osteoporosis is to build strong, dense bones in the early years. A combination of disease,
      endocrine and nutritional factors likely contribute to the etiology of osteoporosis in this
      population. However, even well transfused patients with normal gonadal function who are
      supplemented with calcium have low bone mass. It is hypothesized that patients with
      thalassemia have low bone mass, in part, due to zinc deficiency. Sub-optimal zinc status has
      been identified in patients with thalassemia and zinc supplementation has been shown to
      improve linear growth. To test the primary hypothesis, an 18 month randomized
      placebo-controlled trial of zinc supplementation (25 mg Zn/day) vs. placebo will be conducted
      in 60 young patients (6-30 yrs) with thalassemia and low bone mass (spine BMD Z-score <-1.0).
      Bone health, as estimated from measurements of bone mass (by DXA and pQCT) and markers of
      bone formation and resorption will be the primary outcome variables. This will be the first
      study to examine the effects of zinc. supplementation on bone health in patients with
      thalassemia. If zinc supplementation is found to have a clinically important effect, this
      simple, safe, non-invasive therapy could quickly become a part of the standard care of these
      young patients and improve overall health in children and adult patients with thalassemia
    

Intervention name(s): Zinc; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 25 mg of elemental zinc as zinc sulphate take once daily for 18 months; Placebo capsule, identical to the zn capsule in size, shape and color, taken once daily for 18 months
Other intervention name(s): zinc sulphate; elemental zinc; "sugar" pill
Intervention MeSH terms: Zinc; Zinc Sulfate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: zinc, thalassemia, bone mineral density
Effects of Tai Chi for Early Pulmonary Rehabilitation in Elderly Patients With AECOPD
Condition: Pulmonary Disease, Chronic Obstructive
MeSH terms: Lung Diseases; Pulmonary Disease, Chronic Obstructive
Study type: Interventional

Summary: 
      The goal of this clinical trial is to learn about the therapeutic effect of Chinese
      traditional exercise Tai Chi in elderly acute exacerbation of chronic obstructive pulmonary
      disease (AECOPD) with malnutrition. The main questions it aims to answer are:

        1. Improvement of pulmonary function in patients with Tai Chi exercise;

        2. Improvement of pulmonary function in patients with Tai Chi exercise.

      The patients in control group were given routine nursing care model, including:

        1. Providing basic nursing care and protection for patients according to their needs,
           paying attention to the care of patients' airways, and providing relevant protection and
           auxiliary interventions according to the needs of patients when carrying out nebulized
           inhalation interventions;

        2. Customized nutritional supplementation recipes by specialists in clinical nutrition,
           giving high-protein and low-carbohydrate diets, and giving enteral or parenteral
           nutritional support to those who have insufficient food intake through the mouth;

        3. Carrying out health education and psychological care to alleviate the patients'
           psychological burdens.

      On the basis of the routine care model of the control group, a Tai Chi training program was
      developed in Tai Chi group. Tai Chi training lasted for a total of 6 months, with 4 training
      sessions scheduled per week, each session lasting about 40 minutes. Experts from Anqing Tai
      Chi Association were invited to guide the training. The training program consists of a
      5-minute pre-training warm-up, a 30-minute Tai Chi exercise, and a 5-minute post-training
      stretching session. The Tai Chi training was done at a moderate intensity, with the heart
      rate limited to 60%~80% of the maximal heart rate, where:

      maximal heart rate=220-age. Accelerometers were worn for each member to record heart rate
      changes during training, and when the heart rate exceeded the standard range, the exercise
      intensity could be adjusted to keep the heart rate within a reasonable range.
    


Intervention name(s): Tai-chi exercise
Intervention type(s): Behavioral
Intervention description(s): Traditional Chinese Tai Chi Movement
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Effectiveness of Nanoone Woman Underwear Using in the Management of Dysmenorrhea
Condition: Dysmenorrhea
MeSH terms: Dysmenorrhea
Study type: Interventional

Summary: 
      To evaluate the mean change in menstrual pain intensity during menstrual cycles from baseline
      after wearing Nanoone Woman Underwear in women with primary dysmenorrhea
    

Detailed description: 
      The severity of dysmenorrhea pain experienced by subjects will be evaluated on a VAS, ranging
      from zero (no pain) to ten (very severe pain). Subjects will be asked to use the VAS scoring
      system to record, on a provided sheet, their experienced menstrual pain level daily during
      menstrual bleeding for a total of three consecutive menstrual cycles.
    

Intervention name(s): Nanoone Woman Underwear
Intervention type(s): Device
Intervention description(s): Chen Yi Enterprise, Co., Ltd. design a kind of negative ion materials can supply delocalized electron, and add fiber inside, make clothes to wear in the body, no external power or battery, only depend on infrared body photon hit of thermoelectric effect or heart compression pulse, blood flow of piezoelectric, therefore can sustained sufficient amount of effective negative ion, to eliminate positive ions in vivo, or make oxygen free radical to obtain the lack electrons. Decrease active free radical and get non toxic effect in short time.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research