bioihbjkbjnl/mcl2 huggingface dataset:
Comparison of Pain Relief After Upper and Lower Lumbar Erector Spinae Plane Block
Condition: Pain, Chronic
MeSH terms: Chronic Pain
Study type: Interventional

Summary: 
      The primary endpoint of this study was to identify if eretor spinae plane block (ESPB) has
      any effect in relieving low back pain or leg pain in lumbar radiculopathy. The secondary
      endpoint was to compare the number of spread level when upper or lower lumbar ESPB was
      performed.
    

Detailed description: 
      The erector spinae plane block (ESPB) is a less invasive, safer, and technically easy
      alternative procedure to conventional neuraxial anesthetic techniques. In contrast to common
      neuraxial techniques such as paravertebral and epidural injections, the ESPB targets an
      interfascial plane which is far from the spinal cord, root, and pleura. First applied to
      thoracic neuropathic pain, currently ESPB is being applied to postoperative pain control and
      includes variable clinical situations. In the abdomen and thoracic wall, thoracic ESPB can be
      applied for pain control after cardiac surgery, video-assisted thoracic surgery, laparoscopic
      cholecystectomy, and thoracotomy. Recently, favorable postoperative pain control after lumbar
      spinal or lower limb surgeries has been reported with lumbar ESPB. In addition, ESPB has also
      been used for chronic pain conditions in the upper and lower extremities. To investigate the
      possible mechanism of action of the ESPB, many previous studies have focused on examining the
      physical spread of the injected agent. Commonly, contrast dye injections in human cadavers
      have been utilized to assess the spread level. Physical spread level was determined using
      various methods including direct dissection or sectioning, computed tomography (CT),
      thoracoscopic inspection, or magnetic resonance imaging (MRI) with radiocontrast injection.
      Apart from human cadaver studies, physical spread level has been evaluated in alive patients
      using a variable volume of local anesthetics mixed with radiocontrast. However, these studies
      are limited by the small number of included patients. Therefore, the exact spread level of
      injected local anesthetics remains unclear and a study on a large number of patients is still
      required
    

Intervention name(s): Erector spinae plane block
Intervention type(s): Procedure
Intervention description(s): fascial plane injection guided by fluoroscopy device
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Pain, Lumbar, Spread
The Effects of a Single Dose of Wild Blueberries on Mood and Cognition in Healthy Young Adults
Condition: Mood; Affect; Cognition
Study type: Interventional

Summary: 
      This study aims to investigate whether consuming a drink containing powdered blueberries
      (equivalent to 150 g fresh fruit) can improve mood and cognition in healthy young adults.
      Blood biomarkers of inflammation and neurotransmitter turnover will be analyzed as well as
      responses to computer-based cognitive tasks designed to measure verbal memory, executive
      function, and emotional processing.
    

Detailed description: 
      The present study will examine the psychological effects of a single dose of freeze-dried
      wild blueberries using a randomized, double-blind, placebo-controlled, counterbalanced,
      crossover design. A total of 30 healthy young adults will consume two drinks: one containing
      22 g blueberry powder and the other containing 22 g matched placebo powder in counterbalanced
      order one week apart. The investigators will assess changes in transient mood,
      cognitive-emotional function, and serum biomarkers of inflammation, neuroplasticity, and
      monoamine metabolism from baseline to 2 hours post-ingestion.
    

Intervention name(s): Wild blueberry powder; Placebo powder
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 22 g freeze-dried wild blueberry (Vaccinium angustifolium) powder, mixed with 250 ml water, and served in an opaque container.; 22 g placebo powder matched for macronutrients and flavor, mixed with 250 ml water, and served in an opaque container.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: blueberry; anthocyanins; flavonoids
Developing an US-MRI Biomarker Fusion Model for Endometriosis
Condition: Endometriosis; Reproductive System Disorder
MeSH terms: Endometriosis
Study type: Observational

Summary: 
      Single centre, prospective, observational, cohort study looking to develop a database
      representing the variability of disease and imaging seen in women with clinically diagnosed
      endometriosis, awaiting laparoscopic surgery.
    

Detailed description: 
      In the United Kingdom (UK), endometriosis is one of the most common gynaecological diseases
      needing treatment. The prevalence of disease is often underestimated, however it is believed
      to affect at least 1 in 10 women in the UK. Within the NHS, endometriosis costs the UK
      economy approximately £8.2 billion a year in treatment, loss of work and healthcare costs.

      Currently, the first diagnostic recommendation for endometriosis is and Ultrasound (US) scan
      or a MRI, followed by a diagnostic surgery called laparoscopy. Accurate diagnoses is usually
      limited to specialist tertiary centres, therefore a delayed diagnosis is a significant
      problem for women with endometriosis. Limited experience in the disease area can also lead to
      misdiagnosis and the latest report from the National Institute of Clinical Excellence (NICE)
      reports a time delay of around 7.5 years before a confirmed diagnosis of endometriosis. A
      model that could accurately predict surgical findings of endometriosis would be of
      significant clinical and economical benefit.

      The main aim of this study is to curate a database of patients with varying levels of
      endometriosis. This database will contain fully anonymised MR and US images alongside
      clinical data for further use in research. There will be no intervention outside of standard
      of care. US and clinical data will be collected during routine visits and patients will be
      offered an additional visit to have a MRI. The ultimate aim is to then use this data to
      develop a widely available diagnostic tool based on MRI and US imaging modalities using
      computer modelling. Validating the predictive model with surgical findings will increase
      confidence and access to advanced imaging for non-experts, allowing clinicians to accurately
      predict surgical findings as well as reduce time to diagnosis.
    

Intervention name(s): Outpatient MRI
Intervention type(s): Diagnostic Test
Intervention description(s): All participants will undergo a standardised imaging protocol in a MRI scanner. This will take place during the same visit or following the transvaginal ultrasound (TVUS) and in advance of any surgical procedure (laparoscopy).
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Women with clinically diagnosed endometriosis and awaiting laparoscopic surgery
      
Keywords: Reproductive health; Diagnostics; Magnetic Resonance Imaging; Ultrasound; Biomarkers
A Pharmacokinetics, Safety and Tolerability Study of Multiple Formulations of BMS-986231 in Healthy Participants
Condition: Heart Failure
MeSH terms: Heart Failure
Study type: Interventional
Phase: Phase 1

Summary: 
      Main Objective of this study is to compare the single intravenous (IV) infusion
      pharmacokinetics (PK) of BMS-986231 and its metabolites (BMT-284730, BMT-279554, and
      CAR-000463) following of up to 2 test formulations of BMS-986231 relative to the reference
      formulation.
    

Detailed description: 
      Participants will be randomized 1:1:1:1 and dosed with either of the 4 treatments: A, B, C,
      or D; followed by review of safety and tolerability data during and after the infusion. The
      study will proceed with treatments A, and C unless one or more of these treatments shows poor
      tolerability; in which case the study may proceed with treatment B or D in the follow-up
      cohorts. Additional participants will be randomized equally to each of the treatments the
      study will proceed with.
    

Intervention name(s): BMS-986231 Formulation A; BMS-986231 Formulation B; BMS-986231 Formulation C; BMS-986231 Formulation D
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Participants will be administered BMS-986231 Formulation A as IV infusion for 48 hours.; Participants will be administered BMS-986231 Formulation B as IV infusion for 48 hours.; Participants will be administered BMS-986231 Formulation C as IV infusion for 48 hours.; Participants will be administered BMS-986231 Formulation D as IV infusion for 48 hours.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Characterization of Rectal Cancer Hypoxia Using pO2 Histography and Immunohistochemistry for Hypoxia-Related Proteins
Condition: Rectal Cancer
MeSH terms: Rectal Neoplasms; Hypoxia
Study type: Interventional

Summary: 
      The purpose of this study is to see if the cells in rectal cancer are oxygen-starved, or
      hypoxic. We know that as cancers grow bigger, parts of them are cut off from the oxygen
      supply and they become hypoxic, basically, lacking oxygen. Research has shown that cells that
      are oxygen-starved respond differently to treatment such as chemotherapy and radiation when
      compared to cells that are oxygen rich.
    


Intervention name(s): Eppendorf hypoximeter
Intervention type(s): Procedure
Intervention description(s): Patients consented to the protocol will proceed to their surgery date without any change in the standard preoperative period. After arriving in the operating room, the patient will undergo intravenous general anesthesia (or spinal/epidural anesthesia) by the anesthesiologist and will receive 40% oxygen. At this time, the principal investigator (along with the assistance of the operating surgeon and a member of the Department of Medical Physics) will use the Eppendorf hypoximeter to gather pO2 measurements. We anticipate that this will add no more than fifteen minutes to the planned procedure. Once the measurements are collected, the anesthesia will be adjusted as appropriate for the surgery and the procedure will continue as usual.
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Direct pO2 Measurements; 10-121
the Association Between Obesity and Early Puberty
Condition: Early Puberty
MeSH terms: Puberty, Precocious
Study type: Observational

Summary: 
      childhood obesity and early puberty are closely related, but existing reports usually focus
      on their relationship from the perspective of phenotype. This study was designed to
      investigate the association between obesity-related genic polymorphisms and the risk of early
      puberty in Chinese Han girls.
    

Detailed description: 
      the genotypes of obesity-related SNPs were determined and the unstimulated luteinizing
      hormone, follicle stimulating hormone and estradiol levels were also detected.
    

Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Chinese Han girls from Shenzhen Children's Hospital or monitoring schools in Shenzhen
Comparison Between 2 Techniques for Bilateral Salpingectomy
Condition: Sterility, Female
MeSH terms: Infertility; Infertility, Female
Study type: Interventional

Summary: 
      A comparison between 2 techniques for bilateral salpingectomy during cesarean section.

      Primary outcomes are total operative time and bilateral completion of the randomized
      procedure. Secondary outcomes included surgical complications and post operation
      complications.
    

Detailed description: 
      Ovarian cancer is the most lethal gynecologic malignancy. Major contributors to this high
      mortality are the lack of effective screening strategies, diagnosis at advanced stage of
      presentation as well as the high risk of recurrence. In the last years the Gynecologic
      Associations worldwide have recommended that total salpingectomy be considered for potential
      ovarian cancer risk reduction in benign gynecologic surgeries after completion of
      childbearing.

      However, the data are limit regarding the Preferred surgical technique during cesarean
      section.

      In this randomized controled trial the investigators will compare between various techniques
      for bilateral salpingectomy during cesarean section.

      Primary outcomes are total operative time and bilateral completion of the randomized
      procedure. Secondary outcomes included surgical complications and post operation
      complications.
    

Intervention name(s): LIGASURE; Clamping and suturing
Intervention type(s): Device; Procedure
Intervention description(s): Electricity based cautery tool used during both laparoscopic and open surgery for optimal hemostasis.; Step by step clamping and suturing of the mesosalpinx until achievement of total salpingectomy.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Care Provider)
Primary purpose: Treatment
Evaluating the Initial Lens Handling Experience of Neophyte Contact Lens Wearers Fitted With Precision1 and 1-Day Acuvue Moist Contact Lenses
Condition: Myopia
MeSH terms: Myopia
Study type: Interventional

Summary: 
      The initial subjecting handling experience of neophyte contact lens wearers with Precision1
      will be compared to that with a daily disposable lens which mas been on the market for
      numerous years (1-Day ACUVUE Moist).
    


Intervention name(s): Verafilcon A; Etafilcon A
Intervention type(s): Device; Device
Intervention description(s): Daily disposable silicone hydrogel contact lenses indicated for the optical correction of refractive ametropia (myopia and hyperopia); Daily disposable silicone hydrogel contact lenses indicated for the optical correction of refractive ametropia (myopia and hyperopia)
Other intervention name(s): Precision1™; Acuvue® Moist
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Role of Pepsin Assay in Wheezy Infants
Condition: Gastroesophageal Reflux Disease
MeSH terms: Gastroesophageal Reflux
Study type: Interventional
Phase: Phase 4

Summary: 
      Wheezy infants were tested for gastro-esophageal reflux disease (GERD) using combined
      multiple channel intraluminal impedance-pH (MII-pH), esophagogastroduodenoscope (EGD), lipid
      laden macrophage index and BAL pepsin. Wheezy infants with abnormal MII-pH or reflux
      esophagitis were given domperidone and omeprazole then re-evaluated for symptoms control and
      exacerbations recurrence.
    

Detailed description: 
      Wheezy infants were tested for gastro-esophageal reflux disease using combined MII-pH, EGD,
      LLMI and BAL pepsin. Wheezy infants with abnormal MII-pH or reflux esophagitis were given
      domperidone and omeprazole for 12 weeks then re-evaluated for symptoms control and wheeze
      exacerbations recurrence.
    

Intervention name(s): Omeprazole and domperidone
Intervention type(s): Drug
Intervention description(s): wheezy infants with abnormal MII-pH or reflux esophagitis will be given omeprazol(10mg/once/day) and domperidone (0.2mg/kg/day t.d.s)
Other intervention name(s): omipak , motilium
Intervention MeSH terms: Domperidone; Omeprazole
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Does the Optic Disc Grading Done Visually by Your Doctor Agree With Optic Nerve Testing Which is Done by Machines?
Condition: Open Angle Glaucoma
MeSH terms: Glaucoma; Glaucoma, Open-Angle
Study type: Observational

Summary: 
      The purpose of this study is to determine how well the DDLS (Disc Damage Likelihood Scale)
      (which is a method used by the eye doctor to evaluate how healthy the optic nerve is)
      measures up to the standard glaucoma tests: OCT (Optical Coherence Tomography), the HRT
      (Heidelberg Retinal Tomography) and the HVF (Humphrey Visual Field).
    

Detailed description: 
      The Disc Damage Likelihood Scale (DDLS) has been shown to be a reproducible method for
      clinicians to evaluate the optic nerve for glaucomatous damage and is highly correlated to
      diagnosis of glaucoma, severity of glaucoma as evidenced by visual field loss and Heidelberg
      Retina Tomography (HRT) evaluation. In comparison with the commonly used cup-disc ratio, the
      DDLS has less inter-observer variation and captures glaucomatous aspects of the optic nerve
      not assessed by the cup-disc ratio. The optic nerve imagers do not have the potential to
      completely replace the clinical examination of the optic nerve since they do not assess many
      critical features such as optic nerve pallor, hemorrhages, asymmetry of disc size, edema,
      etc. The DDLS presents the opportunity to provide a system to clinicians to increase the
      quality and objectivity of clinical optic nerve evaluation. The purpose of this study is to
      investigate the correlation of the DDLS grading to OCT, HRT and HVF testing of glaucomatous
      and normal optic nerves.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        glaucoma service
      
Keywords: primary open angle glaucoma; low tension glaucoma; pigmentary glaucoma; exfoliative glaucoma
An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia
Condition: Hypercholesterolaemia
MeSH terms: Hyperlipoproteinemia Type II; Hypercholesterolemia
Study type: Interventional
Phase: Phase 3

Summary: 
      Primary Objective:

      To evaluate the efficacy of alirocumab administered every 2 weeks (Q2W) and every 4 weeks
      (Q4W) versus placebo after 24 weeks of double-blind (DB) treatment on low-density lipoprotein
      cholesterol (LDL-C) levels in participants with heterozygous familial hypercholesterolemia
      (heFH) 8 to 17 years of age on optimal stable daily dose of statin therapy ± other lipid
      modifying therapies (LMTs) or a stable dose of non-statin LMTs in case of intolerance to
      statins.

      Secondary Objectives:

        -  To evaluate the efficacy of alirocumab versus placebo on LDL-C levels.

        -  To evaluate the effects of alirocumab versus placebo on other lipid parameters.

        -  To evaluate the safety and tolerability of alirocumab in comparison with placebo.

        -  To evaluate the efficacy, safety, and tolerability of alirocumab after open label
           treatment.

        -  To evaluate the development of anti-alirocumab antibodies.
    

Detailed description: 
      The study duration was approximately up to 110 weeks (run-in period [if needed]: up to 4
      weeks [+2 days], screening period: up to 2 weeks [+5 days], double-blind treatment period: 24
      weeks, open label (OL) treatment period: 80 weeks).
    

Intervention name(s): Alirocumab SAR236553 (REGN727); Rosuvastatin; Atorvastatin; Simvastatin; Pravastatin; Lovastatin; Fluvastatin; Ezetimibe; Cholestyramine; Nicotinic acid; Fenofibrate; Omega-3 fatty acids; Placebo
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Pharmaceutical form:solution Route of administration: subcutaneous injection; Pharmaceutical form:tablet Route of administration: oral; Pharmaceutical form:Tablet Route of administration: Oral; Pharmaceutical form:Tablet Route of administration: Oral; Pharmaceutical form:Tablet Route of administration: Oral; Pharmaceutical form:Tablet Route of administration: Oral; Pharmaceutical form:Capsule Route of administration: Oral; Pharmaceutical form:Tablet Route of administration: Oral; Pharmaceutical form:oral suspension Route of administration: oral; Pharmaceutical form:Tablet Route of administration: Oral; Pharmaceutical form:Tablet Route of administration: Oral; Pharmaceutical form:capsule Route of administration: oral; Pharmaceutical form:solution Route of administration: subcutaneous injection
Other intervention name(s): Praluent
Intervention MeSH terms: Nicotinic Acids; Niacin; Niacinamide; Atorvastatin; Rosuvastatin Calcium; Simvastatin; Ezetimibe; Pravastatin; Alirocumab; Lovastatin; Cholestyramine Resin; Fenofibrate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Impact of Coffeeberry Extract on Skill Performance During Simulated Match Play in Academy Football Players
Condition: Skill Performance; Soccer Performance; Coffeeberry Effects
Study type: Interventional

Summary: 
      This study of soccer skill performance has three objectives:

        1. Compare effects of coffeeberry (300mg) and placebo ingestion on dribbling speed and
           precision, passing speed and accuracy, and sprint speed during a full simulated soccer
           match.

        2. Compare effects of coffeeberry (300mg) and placebo ingestion on subjective measures
           (mental / physical energy and activation-deactivation (feelings or mood) during a full
           simulated soccer match.

        3. Compare effects of coffeeberry (300mg) and placebo ingestion on chlorogenic acid (CGA)
           and caffeine metabolites in the blood 1-hour post ingestion, and other blood metabolites
           (glucose/lactate) throughout the simulated soccer match.
    


Intervention name(s): Beverage
Intervention type(s): Other
Intervention description(s): Free from added carbohydrates (contain 1g CHO only) and electrolytes are absent.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: coffeeberry; caffeine; polyphenols; chlorogenic acid; exercise; soccer; football; skill; performance