Role of Antioxidants in the Reduction of Oxidative Stress in Infertile Patients
Condition: Infertility; Oligoasthenozoospermia; Male
MeSH terms: Infertility
Study type: Interventional
Phase: Phase 4

Summary: 
      Numerous studies verify that the majority of cases of male infertility belong to the group
      diagnosed with oligoasthenoteratozoospermia (OAT), which means a decrease in the number of
      sperm in the ejaculate to 15 million / ml, reduced sperm motility of the spermatozoa and
      morphological disorders of the neck or tail of the sperm.

      Genuine scientific studies can not pinpoint the cause of these changes, however, recent
      advances in science shed light on this issue by confirming the reason, which is as a result
      of the action of free radicals - oxidative stress.
    

Detailed description: 
      The enlightenment project in the field of male infertility in North Macedonia will include a
      wide team of: students, general practitioners, assistants, professors of pre-clinical
      subjects, professors and specialists in the field of gynecology, urology and andrologists.
      The involvement of such a large number of professionals once again verifies the seriousness
      and determination that this scientific project has.

      Investigators hope to contribute generously to:

        1. Identifying new cases and taking measures early, in order to overcome fertilization
           problems;

        2. For the first time in North Macedonia there will be a more accurate picture of the
           prevalence of male infertility;

        3. Expanding current scientific knowledge about the role of oxidative stress, its
           laboratory evaluation, and the impact of antioxidant supplements;

        4. Standardization of doses and type of antioxidant supplements that will be used during
           the realization of this dissertation and evaluation of their clinical effect in men with
           OAT;

        5. After the implementation of antioxidant therapy, investigators expect that the results
           of live births and spontaneous pregnancies will increase, while the number of
           miscarriages will decrease;

        6. Acquisition of knowledge on laboratory and clinical evaluation techniques of infertile
           men, which would later lead to the establishment of an andrological laboratory.
           Investigators anticipate this laboratory to function within the Faculty of Medical
           Sciences, where all procedures will be performed, from diagnosis to the operation of
           assisted reproduction techniques (TRA). This, in addition to the material benefit for
           the benefit of the University of Tetova, also has a benefit in terms of staff, which
           will be professionalized and trained during the realization of this dissertation.
    

Intervention name(s): Antioxidant formula
Intervention type(s): Combination Product
Intervention description(s): Administration of antioxidant formula 3 times a day and once daily.
Intervention MeSH terms: Antioxidants
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Double blind randomized
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: antioxidant; oxidative stress; sperm parameters; Malonedialdehyde; total antioxidant capacity