bioihbjkbjnl/mcl2 huggingface dataset:
Cancer Screening Utilization Rates and Cancer Screening Perspectives of Hospitalized Women
Condition: Cancer Screening
Study type: Interventional

Summary: 
      Breast and colon cancers are commonly diagnosed cancers among women after skin cancer in
      Maryland. Patients' preferences for cancer screening are known to significantly influence
      utilization, and thus impact health outcomes. In a recent study the investigators conducted
      at Johns Hopkins Bayview Medical Center, the investigators observed that among women age
      50-75 years admitted to general medicine services over 4-month period, 40% were non-adherent
      to breast cancer screening (overdue) despite being insured.

      Therefore, the investigators propose to establish a cohort of hospitalized women to help the
      investigators develop successful interventions for enhancing breast cancer screening
      utilization in this group. In following a cohort prospectively, the investigators intend to
      both reaffirm the results from the investigators' previous study and determine whether the
      patterns of mammographic screening improve over time as a result of the investigators'
      interventions. Among non-adherent (overdue) women, the investigators will educate and
      encourage these women to undergo outpatient screening mammography.

      To more comprehensively assess the preventive health in this cohort, the investigators will
      assess the cohort's adherence to colon cancer screening recommendation and barriers to colon
      cancer screening.

      In addition the investigators will also like to encourage the hospitalists and house staff
      taking care of these patients to perform oral cancer screen among women who smoke
      (non-adherent to breast cancer screening) Finally the investigators will also like to ask the
      perspective of cancer screening among these women.
    


Intervention name(s): Cancer screening education for breast, colon and oral cancers
Intervention type(s): Behavioral
Intervention description(s): Bedside education one-on-one by showing screening video and handouts at the end of educational session for breast, colon and oral cancer. Patient who are agreeable to oral cancer screen during hospitalization perform oral cancer screening
Intervention model: Single Group Assignment
Intervention model description: Cancer screening utilization rates and cancer screening perspective of hospitalized women on internal medicine service
Masking: None (Open Label)
Primary purpose: Health Services Research
Study to Evaluate EB-001 in Reducing Musculoskeletal Pain
Condition: Musculoskeletal Pain
MeSH terms: Musculoskeletal Pain
Study type: Interventional
Phase: Phase 2

Summary: 
      To determine the safety and efficacy of single intra-operative treatment of EB-001 IM
      injections into the Pectoralis Major (PM) in subjects undergoing breast augmentation with
      subpectoral implants
    

Detailed description: 
      This study will evaluate the safety and efficacy of EB-001 in decreasing post-surgical pain
      in patients undergoing surgical breast augmentation with subpectoral placement of the
      implants. Intramuscular (IM) injection of EB-001 into the PM bilaterally during surgery may
      decrease pain related to stretching of the PM by the implants.

      The safety objective is to determine the safety and tolerability of single intraoperative
      treatment of EB-001 IM injections into the PM in subjects undergoing breast augmentation with
      subpectoral implants.

      The efficacy objective is to evaluate the efficacy of intraoperative administration of EB-001
      IM into the PM in reducing the pain and use of rescue pain medications in subjects undergoing
      breast augmentation with subpectoral implants.
    

Intervention name(s): Placebo; EB-001
Intervention type(s): Drug; Drug
Intervention description(s): Placebo- Single injection of saline into Pectoralis Muscle; Single injection of EB-001 into Pectoralis Muscle
Allocation: Randomized
Intervention model: Sequential Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Effects of Antenatal Exercises on Maternal Birth Outcomes
Condition: Pregnancy Related
Study type: Interventional

Summary: 
      The study is aimed to determine the effects of pelvic floor stretching Vs strengthening on
      maternal birth outcomes and postpartum urogenital distress in primigravida.
    

Detailed description: 
      The effects of pelvic floor muscle exercises on the symptoms of postpartum urinary distress
      is not known, so there is a need to determine whether strengthening or stretching of pelvic
      floor muscles help in reducing the risk of developing urogenital distress in postpartum
      period of females. The positive effect of pelvic floor muscle training on duration of labor
      and maternal birth outcomes is understood. As stated in a systemic review of pelvic floor
      interventions during pregnancy. The researches done on effect of pelvic floor muscle
      exercises, included once a week supervised session of sustained pelvic floor muscle
      contractions with rest intervals and fast contractions with respective rest intervals along
      with daily home sessions of the same exercises.
    

Intervention name(s): Pelvic floor stretching; Pelvic floor strengthening
Intervention type(s): Other; Other
Intervention description(s): Week 1 to 4: Pelvic floor muscles awareness, Breathing exercises , seated pelvic tilts, cat stretches, seated hip openers (2 sets, 8 reps, sustained for 6 seconds) Week 5 to 8: Pelvic floor muscles awareness, Breathing exercises ,seated pelvic tilts, cat stretches, Seated hip openers, Relaxed Frog (2 sets, 8 reps, sustained for 6 seconds) Week 9 to 13: Pelvic floor muscles awareness, Breathing exercises, seated pelvic tilts, cat stretches, Seated hip openers, Relaxed Frog side lying clamshells, mini squats with support (2 sets, 9 reps, sustained for 7 seconds); Week 1 to 4: Pelvic floor muscles awareness, Breathing exercises, 2 Sets of 10 Reps for pelvic floor squeeze and release Seated marching with elastic band with pelvic floor squeeze.
Week 5 to 8: 2 sets x 9 Reps for Pelvic floor squeeze and release, Seated marching with elastic band with pelvic. 2 Sets x 8 Reps for bridging with pelvic floor squeeze, side lying hip circles Week 9 to 13: 2 sets 10 reps for Pelvic floor squeeze-and-release, Seated marching with elastic band with pelvic floor squeeze, pelvic bridging with pelvic floor squeeze, side lying hip circles with pelvic floor squeeze. 2 sets, 8 reps for . side lying Clamshells with resistance band and pelvic floor squeeze and plie squats with pelvic floor squeeze
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Pregnancy Related; Pelvic Floor Muscle Weakness; Delivery Delayed
Specific IgG Antibody in Patients With Primary Antibody Deficiencies Treated With Subcutaneous Immunoglobulin
Condition: Common Variable Immunodeficiency; Agammaglobulinemia
MeSH terms: Agammaglobulinemia; Primary Immunodeficiency Diseases; Common Variable Immunodeficiency
Study type: Interventional

Summary: 
      Objective: Measure serum IgG antibody to Streptococcus pneumoniae serotypes 1, 3, 5, 6B, 9V e
      14, Haemophilus influenzae type b and tetanus toxoid in patients with primary antibody
      deficiencies who were treated with subcutaneous immunoglobulin infusions.
    

Detailed description: 
      Therapy with polyvalent immunoglobulin (Ig) has been established as the standard therapy for
      antibody deficiencies for several decades now. Although subcutaneous infusions were
      originally proposed as an alternative to intramuscular injections, more recently, this method
      has been proven as a safe and convenient method for providing immunoglobulin levels in adults
      and children. Subcutaneous administration of immunoglobulins has some clinical advantages
      over intravenous immunoglobulin infusions (IVIG) , including a more benign side effect
      profile, better sustained levels of IgG in the blood and reduced cost. An additional benefit
      is an improvement in the quality of life, which is in part secondary to the feasibility of
      the patients to administer it themselves at home. The most common infections in primary
      antibody deficiency patients involves encapsulated bacteria, mainly Streptococcus pneumoniae
      and Haemophilus influenzae type b. The aim of this study is to verify if patients with
      antibody deficiency receiving subcutaneous immunoglobulin (SCIG) infusions keep protective
      antibody levels to Streptococcus pneumoniae, Haemophilus influenzae type b (Hib) and tetanus
      toxoid.
    

Intervention name(s): gammaglobulin
Intervention type(s): Biological
Intervention description(s): They were administered a polyvalent, pasteurized liquid immune globulin subcutaneously (human 16% Beriglobin ®, Germany) with doses ranging from 57 to 132 mg/kg/week in order to maintain the same dosage they received by intravenous route monthly previous to this protocol. After a wash-out period (15 weeks) of the subcutaneous immunoglobulin administration, blood was collected every 4 weeks immediately before infusions. The infusions were administered using battery-powered ambulatory syringe drivers together with 10 or 20 ml syringe and infusions sets according to a pre-defined protocol (Gardulf et al, 2006).
Other intervention name(s): Beriglobin 17540311E
Intervention MeSH terms: gamma-Globulins
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: gammaglobulin; subcutaneous infusion; specific antibodies; primary antibody deficiency
A New Treatment Option for Mastalgia
Condition: Mastalgia
MeSH terms: Mastodynia
Study type: Interventional

Summary: 
      The main objective of this study is to determine the effectiveness of transcutaneous
      electrical nerve stimulation (TENS) treatment on pain and quality of life in mastalgia, which
      treatment has not yet reached a consensus.
    

Detailed description: 
      The main objective of this study is to determine the effectiveness of transcutaneous
      electrical nerve stimulation (TENS) treatment on pain and quality of life in mastalgia, which
      treatment has not yet reached a consensus. This randomized controlled clinical trial was
      completed with 20 women suffering from mastalgia. Patients were randomly assigned to the TENS
      treatment and sham application groups. Pain intensity, pain patterns and quality of life were
      evaluated with Breast Pain and SF-36 questionnaires before and 10 days after treatment in all
      patients.
    

Intervention name(s): TENS
Intervention type(s): Device
Intervention description(s): Transcutaneous electrical nerve stimulation (TENS) is a non-invasive treatment method widely used for pain control
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Prevalence of Sub Clinical Hypothyroidism During Early Pregnancy in Pakistan
Condition: Subclinical Hypothyroidism
MeSH terms: Hypothyroidism
Study type: Observational

Summary: 
      The Precious study is likely to help determine the frequency (percentage) of subclinical
      hypothyroidism among pregnant women in Pakistan It will also help to determine the risk
      factors for developing subclinical hypothyroidism during pregnancy
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Primary Care Clinic/Private Clinic
      
Keywords: subclinical hypothyroidism in pregnancy
Exploring Liver and Muscle Fat Content Using MRI
Condition: Polycystic Ovary Syndrome
MeSH terms: Polycystic Ovary Syndrome; Syndrome
Study type: Observational

Summary: 
      The aim of our study was to compare the difference of fatty infiltration in liver and muscle
      using magnetic resonance imaging (MRI) between overweight as well as obese polycystic ovary
      syndrome (PCOS) cases and body mass index (BMI)-matched women without PCOS, identifying the
      possible influence factors.
    


Intervention name(s): MRI
Intervention type(s): Radiation
Intervention description(s): MRI-mDIXON-Quant examinations, anthropometric measures, body composition, hormonal and biochemical assays were performed in all participants, and the liver fat fraction (LFF) and muscle fat fraction (MFF) represented the fat content in the liver and skeletal muscle, respectively.
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        (1) subjects with other causes of irregular menstrual cycles or androgen excess including
        hyperprolactinemia, uncontrolled thyroid disease, congenital adrenal hyperplasia, Cushing's
        disease, androgen secreting tumor, or pregnancy; (2)subjects with abnormal liver function
        test results (ALT level 2.5 times higher than the upper limit of the normal range); (3)
        subjects with renal insufficiency (eGFR < 60 ml/min/1.73 m2); (4) subjects with a history
        of chronic liver diseases such as alcoholic liver disease, viral hepatitis, autoimmune
        liver disease, drug-induced liver disease, genetic metabolic liver disease; (5) subjects
        experiencing alcoholism (weekly alcohol intake > 100 g) subjects experiencing smoking
        within the past 3 months and engaging in high-intensity exercise; (6) subjects with a
        history of cancer; (7) subjects with active infection; subjects who were pregnant or
        breastfeeding.
Study to Evaluate Drug-Drug Interaction Between IDX719 and Simeprevir in Healthy Participants (MK-1894-004)
Condition: Chronic Hepatitis C Infection
MeSH terms: Hepatitis C; Hepatitis C, Chronic; Hepatitis
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this 3-part study is to evaluate the potential impact of simeprevir and food
      on pharmacokinetics (PK) of IDX719 in healthy participants. Part 1 will evaluate potential PK
      interactions between IDX719 and simeprevir. Part 2 will evaluate the effect of food on the PK
      of IDX719 in combination with simeprevir. Part 3 will evaluate the impact of high- versus
      low-fat meals on the PK of IDX719.
    


Intervention name(s): IDX719; Simeprevir
Intervention type(s): Drug; Drug
Intervention description(s): 50 mg tablet for oral administration; 150 mg capsule for oral administration
Other intervention name(s): Samatasvir; Olysio™
Intervention MeSH terms: Simeprevir
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: HCV; Hepatitis C Virus; Hepatitis C; antiviral drugs; liver
Evaluation of a Short Course of Gamma Tocopherol Supplementation in Adult Subjects
Condition: Gamma Tocopherol Serum Levels
Study type: Interventional

Summary: 
      To evaluate serum levels of gamma tocopherol and it's metabolites after 3 doses, each
      separated by 12 hours.
    

Detailed description: 
      In previous studies the investigators have demonstrated that gamma-tocopherol-enriched (yT)
      supplementation decreased systemic oxidative stress, increased serum levels of yT, and
      inhibited monocyte responses to LPS without any adverse health effects. Free Radic Biol Med.
      2008 Jul 1;45(1):40-9. doi: 10.1016/j.freeradbiomed.2008.03.002. Epub 2008 Mar 12.

      Oxidant stress plays an important role in mucosal inflammation. Oxidant stress occurs
      individuals after exposure to air pollution, including high levels of ozone, LPS exposure and
      woodsmoke particle exposure. Potential exposure to all of these are naturally occurring
      events. Previous studies have also shown that asthmatic individuals tend to have lower
      endogenous levels of antioxidants such a s vitamins E and C, and that supplementing
      antioxidants can decrease exacerbation's associated with ozone exposure in children. The
      investigators are interested in future studies to examine the benefits of a rapid gamma
      tocopherol supplement in individuals who will be exposed to air pollution, either in a
      controlled chamber study or in a real life event, such as during high O3 days or when a
      woodsmoke fire is in their neighborhood.

      This study is to address the question: can the investigators see an increase in serum levels
      of gT with a shorter course of gT supplementation? Additionally, before embarking on other
      investigations of gT as a potential prophylactic supplement, it is prudent to determine is
      discernible levels can be achieved with a shorter dose of gT.
    

Intervention name(s): Gamma tocopherol
Intervention type(s): Dietary Supplement
Intervention description(s): 3 doses of 1400 mg gamma tocopherol (2 capsules, each is 700mg), at 12 hour intervals
Other intervention name(s): Vitamin E
Intervention MeSH terms: Vitamin E; Tocopherols; Tocotrienols; alpha-Tocopherol; gamma-Tocopherol
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Study to Assess the Effect of 24 Weeks of Treatment With Vildagliptin in Patients With Type 2 Diabetes
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 4

Summary: 
      The study will demonstrate the effect of 24 weeks of treatment with vildagliptin compared to
      placebo on insulin sensitivity in patients with type 2 diabetes mellitus (T2DM) treated with
      metformin, assessed as glucose Rd (rate of glucose disposal) during a hyperinsulinemic
      euglycemic clamp.
    


Intervention name(s): Vildagliptin; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Dosage 50mg b.i.d.; 50mg bid
Intervention MeSH terms: Vildagliptin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Diabetes mellitus; vildagliptin
Learning Curve of Fiberoptic Intubation Through Supraglottic Airway Device
Condition: Intubation;Difficult
Study type: Interventional

Summary: 
      This study aims to obtain learning curve data of residents for fiberoptic-guided tracheal
      intubation through supraglottic airway device for pediatric difficult airway manikin.
    

Detailed description: 
      Residents under anesthesiology training will undergo a simulation practice to a pediatric
      airway manikin, after a single demonstration by an expert for fiberoptic-guided tracheal
      intubation through supraglottic airway device. The participants will do the same practice 20
      times to the same manikin.
    

Intervention name(s): Training; supraglottic airway device
Intervention type(s): Other; Device
Intervention description(s): 20-times training of fiberoptic-guided tracheal intubation through supraglottic airway device to pediatric airway manikin; supraglottic airway device
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Fiberoptic bronchoscope; Supraglottic airway
A Study to Compare Two Dose Strengths of CVT-301 (Levodopa Inhalation Powder) With an Oral Dose of Sinemet® (Carbidopa-levodopa) Tablets
Condition: Parkinson Disease
MeSH terms: Parkinson Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will be an open-label, randomized, three-period cross-over pharmacokinetic
      evaluation of CVT-301 compared with the Reference Listed Drug (RLD), orally administered
      carbidopa/levodopa, in healthy volunteers.
    

Detailed description: 
      The primary objective is to determine the relative bioavailability of two CVT-301 (dose
      levels 1 and 2) capsules compared with the Reference Listed Drug (RLD) on a per milligram
      basis.
    

Intervention name(s): CVT-301 (Dose Level 1); CVT-301 (Dose Level 2); Sinemet®
Intervention type(s): Drug; Drug; Drug
Intervention description(s): All subjects will receive a single dose of low-dose CVT-301 with a 1-day washout between the doses.; All subjects will receive a single dose of high-dose CVT-301 with a 1-day washout between the doses.; All subjects will receive carbidopa/levodopa tablets administered every 8 hours.
Other intervention name(s): carbidopa/levodopa
Intervention MeSH terms: Levodopa; Carbidopa; Carbidopa, levodopa drug combination
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Parkinson's disease; Episodic motor fluctuations (OFF periods)
Neurovascular Coupling in Patients With Early Stage Diabetes Retinopathy
Condition: Diabetic Retinopathy
MeSH terms: Retinal Diseases; Diabetic Retinopathy
Study type: Observational

Summary: 
      A variety of studies demonstrate that ocular blood flow is altered in diabetes and retinal
      perfusion abnormalities have been proposed to contribute to the pathogenesis of diabetic
      retinopathy.

      Various animal and human studies have demonstrated that retinal and optic nerve blood flow
      increase in response to diffuse luminance flicker. Based on studies with ERG, this effect has
      been attributed to augmented activity in the retinal ganglion cells and associated axons
      indicating a coupling mechanism between neuronal activity and retinal blood flow. Whereas a
      variety of studies describe the effects of flickering light on retinal and optic nerve head
      blood flow, the knowledge about this coupling in the diabetic retina is sparse.

      In view of the fact that neural activity and blood flow are strongly coupled in the human
      retina, one could hypothesize that neurodegenerative changes in the retina could contribute
      to the vascular dysregulation and in turn lead to changes of ocular perfusion. The
      investigators set out to investigate whether the coupling of neural activity and blood flow
      is impaired in patients with early stage diabetic retinopathy compared to those in healthy
      volunteers.
    


Intervention name(s): Ocular blood flow measurements
Intervention type(s): Other
Intervention description(s): non-invasive haemodynamic measurements of retinal vessel diameters and laser Doppler velocimetry
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        50 Patients with Diabetes Type 1 50 Healthy Control Subjects
      
Keywords: Diabetes; ocular blood flow
Pharmacokinetic-pharmacodynamic Interaction Between Three Different Single Doses of BIA 9-1067 and a Single-dose of Immediate-release Levodopa/Benserazide
Condition: Parkinson's Disease (PD)
MeSH terms: Parkinson Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      To investigate the effect of three single oral doses of BIA 9-1067 (25 mg, 50 mg and 100 mg)
      on the levodopa pharmacokinetics when administered in combination with a single-dose of
      immediate-release levodopa/benserazide 100/25 mg (Prolopa® 100-25)
    


Intervention name(s): BIA 9-1067; Placebo; Prolopa®
Intervention type(s): Drug; Drug; Drug
Intervention description(s): levodopa/benserazide 100/25 mg
Other intervention name(s): Opicapone, OPC; PLC, Placebo; Prolopa® 100-25
Intervention MeSH terms: Opicapone; Benserazide, levodopa drug combination
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Parkinson's disease (PD); Opicapone; Bia 9-1067