bioihbjkbjnl/mcl2 huggingface dataset:
Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders
Condition: Alzheimer Disease; Neurodegenerative Diseases
MeSH terms: Alzheimer Disease; Neurodegenerative Diseases
Study type: Interventional

Summary: 
      Degenerative dementias including Alzheimer's Disease (AD), Parkinson's Disease with Dementia
      (PDD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementias (FTLD), Corticobasal
      Degeneration (CBD) and Progressive Supranuclear Palsy (PSP) constitute a significant, and
      growing burden with an estimated cost to the US healthcare system for 2016 of $236 Billion
      (1). Definitive diagnosis of these dementias is based on pathological criterion upon autopsy,
      which presents a significant challenge to establish diagnosis in living patients. Although
      clinical diagnostic criteria have been developed for several of these disorders, including
      for Alzheimer's Disease (AD) by the National Institute of Neurological and Communicative
      Disorders and Stroke and Alzheimers Disease and Related Disorders Association (NINCDS-ADRDA)
      , Parkinson's Disease (PD) by the United Kingdom Parkinson Disease Brain Bank Diagnostic
      Criteria (UKPDBB) diagnostic criteria for Parkinson Disease(4) and others, the currently
      available tests, including the use of imaging markers and Cerebrospinal Fluid (CSF)
      biological markers do not provide a definite diagnosis since this requires the observation of
      characteristic neuropathological changes in specific regions of the brain.
    


Intervention name(s): Cytology and Immunohistochemistry
Intervention type(s): Diagnostic Test
Intervention description(s): Determine if nasal swabs can provide an adequate sample for evaluation using cytology and immunohistochemistry for alpha-synuclein, A-beta and p-tau staining.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
A Study to Assess the Immunogenicity and Safety of GSK Biologicals' Infanrix-IPV/Hib Vaccine Administered as a Three-dose Vaccination Course at 3, 4.5 and 6 Months of Age and a Booster Dose at 18 Months of Age in Healthy Infants in Russia
Condition: Diphtheria; Tetanus; Pertussis; Hepatitis B; Haemophilus Influenzae Type b
MeSH terms: Influenza, Human; Hepatitis B; Whooping Cough; Tetanus; Diphtheria
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to evaluate the immune response, safety and reactogenicity after
      receiving combined DTPa-IPV/Hib vaccine when administered as a three-dose primary vaccination
      course at 3, 4.5 and 6 months of age and as a booster dose at 18 months of age in Russian
      healthy children according to the Russian immunisation schedule
    


Intervention name(s): Infanrix-IPV/Hib
Intervention type(s): Biological
Intervention description(s): Subjects receive Infanrix-IPV/Hib three-dose primary vaccination course at 3, 4.5 and 6 months of age and a booster dose at 18 months of age. The vaccine is administered intramuscularly into the upper side of the thigh on the right/left side.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Primary dose; Reactogenicity; Immunogenicity; Booster dose; Combined vaccine; Russian Infants; Infanrix®-IPV/Hib
E-cigarettes, Nicotine Inhaler, and Blood Vessel Function
Condition: Nicotine Dependence
MeSH terms: Tobacco Use Disorder
Study type: Interventional

Summary: 
      Randomized controlled trial of electronic cigarettes with nicotine, without nicotine,
      nicotine inhaler, and sham-control on endothelial function, oxidative stress and sympathetic
      nerve activity
    

Detailed description: 
      Participants will have an acute exposure on 4 occasions1) e-cigarette with nicotine, 2)
      e-cigarette without nicotine, 3) nicotine inhaler, 4) sham control and undergo ECG recording
      for heart rate variability, endothelial function measurement using ultrasound ("FMD") and
      blood tests for oxidative stress markers.
    

Intervention name(s): e-cig with nicotine; e-cig without nicotine; nicotine inhaler; sham control
Intervention type(s): Other; Other; Other; Other
Intervention description(s): use an e-cig with nicotine for 30 minutes; use an e-cig without nicotine for 30 minutes; use a nicotine inhaler for 30 minutes; use an empty e-cigarette for 30 minutes
Intervention MeSH terms: Nicotine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: nicotine; sympathetic nerve activity; oxidative stress
Evaluate the Safety and Effectiveness of Sodium Hyaluronate When Used for the Correction of Nasolabial Folds
Condition: Dermal Filler; Hyaluronic Acid; Lidocaine; Nasolabial Fold
Study type: Interventional

Summary: 
      The aim of this study is to evaluate the safety and effectiveness of pain relief of modified
      sodium hyaluronate gel for injection when used for the correction of moderate or severe
      nasolabial folds.
    

Detailed description: 
      One hundred and thirty patients were enrolled and there two sides of nasolabial folds (NLF)
      were randomized to receive HA with lidocaine or HA. The primary outcome was immediate visual
      analogue scale (VAS) of pain evaluated after injection for both NLF sides. Secondary outcomes
      including VAS pain, wrinkle severity rating scale (WSRS), global aesthetic improvement scale
      (GAIS) and AE were observed at 1, 3, 6, 9, 12 follow-ups.
    

Intervention name(s): HA+Lidocaine; HA
Intervention type(s): Device; Device
Intervention description(s): 20 mg; 20 mg
Intervention MeSH terms: Lidocaine
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Subject's two sides of nasolabial folds (NLF) were randomized to receive FACILLE® Light (contains Lidocaine) or FACILLE® (without Lidocaine).
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Comparison of Two GlideScope Intubation Techniques
Condition: Intubation, Endotracheal; Anesthesia, General
Study type: Interventional

Summary: 
      The aim of this study is to compare the hemodynamic response to tracheal intubations using
      the standard technique versus the alternative GS intubation technique. As secondary outcomes
      the investigators will analyze procedure time, success rate and injury rate.

      The investigators hypothesize that the alternative intubation technique will have a shorter
      procedure time and lower injury rate when compared to the standard technique of GS
      intubation.
    

Detailed description: 
      A Difficult intubation is still one of the most daunting challenges in anesthesiology. One of
      the tools used to assist with a difficult tracheal intubation is the GlideScope (GS)
      (Verathon, Bothell, WA, USA). The GS is a video laryngoscope that has a 60 degree angle blade
      with a built-in high-resolution camera and a light source assembled beside it. The image is
      transmitted onto a mobile bedside monitor. It has been widely used in medicine for over a
      decade. The GS was designed to provide an improved view of the glottis during difficult
      intubations without alignment of the oral, pharyngeal and tracheal axes, as it is able to
      "look around the corner" to facilitate the intubation.

      The standard technique of the GS intubation involves a midline laryngoscopy followed by the
      insertion of a styleted endotracheal tube (ETT) once an adequate view of the vocal cords has
      been achieved. The ETT insertion process requires the operator to look away from the monitor
      during the laryngoscopy while maintaining the blade position in order to insert it into its
      initial position.

      An alternative GS intubation technique has been described for cases in which there is limited
      mouth opening, a big tongue or other anatomical impediments. In these cases the ETT is
      inserted under direct vision as a "fish hook" at the side of the mouth before the GS blade is
      introduced into the oropharynx.

      There are several advantages to this alternative technique. The first advantage is that this
      technique of ETT insertion would minimize the laryngoscopy time as a part of it is performed
      before the blade is introduced and the stimulating effect occurs. This technique thus has the
      potential of reducing the sympathetic response. Minimizing oropharyngo-laryngeal stimulation
      time would theoretically attenuate the hemodynamic response.
    

Intervention name(s): GlideScope
Intervention type(s): Device
Intervention description(s): The GlideScope is used to assist with difficult tracheal intubation.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Laryngoscopy; Intubation; Glidescope
Transmission of Covid-19 During Clubbing Events in Closed Places
Condition: Healthy Participant
Study type: Interventional

Summary: 
      The ITOC study is a cluster randomised, controlled, multicentre trial in Paris region,
      France. The intervention is an 8-hour indoor clubbing event with no mask wearing, no social
      distancing, at maximum room capacity. 1,200 healthy volunteers aged 18-49 years and fully
      vaccinated will be included. Participants are recruited by group of up to 10, to be
      randomized 2:1 to experimental group (800 volunteers in a venue ) or control group (400
      volunteers asked to stay at home). All participants will provide a salivary sample the day of
      experiment and seven days later. Participants will also answer surveys on the social and
      psychological impact of lockdown and indoor club closing, attitude towards vaccination,
      behaviour at risk of COVID-19 transmission during the day of the event (for both groups) as
      well as follow-up surveys on symptoms that participant may experience. Virological analyses
      include polymerase chain reaction (PCR) of salivary samples and air of the venue,
      investigating SARS-CoV-2 PCR.
    


Intervention name(s): Club event
Intervention type(s): Other
Intervention description(s): Participate in a club event without a mask, indoors, with vaccinated people.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Open-label, multicenter, randomized controlled intervention study with 1200 participants distributed 2: 1 in two groups of volunteers.
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: SARS CoV-2; Transmission; vaccinated; Night-club
Mental Health in Austrian Teenagers (MHAT)
Condition: Mental Disorders
MeSH terms: Mental Disorders
Study type: Observational

Summary: 
      The purpose of the Mental Health in Austrian Teenagers (MHAT) - Study is to collect the first
      epidemiological data on mental health and psychiatric disorders in a representative sample of
      Austrian adolescents between 10 and 18 years.
    

Detailed description: 
      Knowing about the prevalence of psychiatric disorders and related risk and protective factors
      is essential for the development of prevention programs and therapeutic approaches. Up to
      now, no epidemiological data on prevalence rates of psychiatric disorders and related risk
      and protective factors based on a representative sample is available for Austrian
      adolescents.

      The aim of the study is to present rates of behavioral, emotional and social problems as well
      as prevalence rates of mental disorders. Furthermore the investigators want to examine risk
      factors, protective factors and quality of life in a large sample of adolescents aged 10 to
      18 years. A two step design is chosen for this purpose to obtain diagnoses based on the
      Diagnostic and Statistical Manual of the American Psychiatric Association, Version 5 (DSM-5):

        1. Phase 1 (screening) is a screening for emotional, behavioral and social problems as well
           as social and demographic correlates, risk and protective factors and quality of life.

        2. Phase 2 (interviews) includes structured diagnostic interviews to assess psychiatric
           diagnoses according to DSM-5 criteria with adolescents above a predefined cut-off score
           in the screening, and a random sample of adolescents scoring below the cut-off.
    

Intervention name(s): 2-phase epidemiological study (screening, interviews)
Intervention type(s): Other
Intervention description(s): first phase is the screening phase, second phase is the interview phase
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        general population
      
Keywords: children and adolescents; mental health; epidemiology; psychiatric disorders
Randomized Control Trial for Overweight Employees in Worksites
Condition: Diabetes Mellitus, Type 2; Metabolic Syndrome; Lifestyle Risk Reduction
MeSH terms: Metabolic Syndrome; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      Impact of lifestyle intervention in at-risk Asian Indians at worksite remains largely
      unexplored. The aim of this study was to assess impact of the multi-component interventions
      on body weight, body fat patterning and cardio-metabolic risk factors in overweight
      individuals working in corporate worksites in New Delhi, north India.
    

Detailed description: 
      A randomized open label clinical trial is planned in 4 worksites. The total study duration is
      18 months. Four workplace sites will be divided into two active intervention and two control
      sites. Intensive awareness generation activities for overweight and obese employees and a
      general awareness health, nutrition and physical education programme for the rest of the
      employees. The study subjects will be part of awareness sessions which will be conducted in
      the 6 month intervention period. Besides group sessions individual diet charts will also be
      worked out by a trained nutritionist. Physical activity advice will be provided to them
      keeping their specific requirements in mind. Pedometers will be provided to them and they
      will be encouraged to walk for 15 minutes in pre-lunch period. Leg movements at the desk will
      also be encouraged.
    

Intervention name(s): Lifestyle intervention
Intervention type(s): Behavioral
Intervention description(s): Intervention Trial with Multi-Component Lifestyle Intervention for reduction of body weight and cardio-metabolic risk factors
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Amniotomy for Second-trimester Pregnancy Termination
Condition: Abortion, Missed
MeSH terms: Abortion, Missed
Study type: Interventional

Summary: 
      The termination of abortion is an important issue that has many controversies. The most
      common time of serious abortion-related complications is the second trimester. Missed
      abortion is one of the most common indications of termination of pregnancy in the second
      trimester. Misoprostol and mifepristone are effective drugs for induction of abortion but
      these drugs are now expensive, and non-available in many developing countries.

      The effectiveness of Foley's catheter balloon on cervical ripping for mid-trimester pregnancy
      termination has been proved before. It can effectually shorten the time of the expulsion of
      the fetus. Amniotomy defines as an artificial rupture of the membranes; it is an ordinary
      obstetric practice used mainly in the induction of labor, with good results and less
      morbidity. The obstetricians used to combine amniotomy with other methods such as
      prostaglandins or oxytocin to induce labor in a woman with an unfavorable cervix.

      Despite plenty of studies that investigated the role of amniotomy for induction of labor but
      the studies which addressed the role of amniotomy in the induction of second-trimester
      abortion are very scarce in the literature.
    


Intervention name(s): Foley catheter balloon; Amniotomy; Oxytocin
Intervention type(s): Device; Procedure; Drug
Intervention description(s): A Cusco speculum will be placed and a 16F Foley catheter will be inserted into the cervix using ring forceps. Then the balloon will be inflated with 40 ml of saline and it will be pulled out to ensure the balloon covered the internal os of the cervix; Amniotomy will be performed by toothed forceps. The handle of the device will be held with one hand outside the vagina while 2 fingers of the opposite hand will be placed in the vagina to guide the tip. Care should be taken to protect maternal vaginal tissues from the forceps. Once the forceps reach the amniotic sac, the tip is pushed up against the sac with the index or middle finger of the internal hand to pierce the membranes. The nature of amniotic fluid will be checked.; The intravenous oxytocin infusion will be administered as 10 IU oxytocin/ 500 ml glucose/ 30 mIU/minute were every 6 hours till complete abortion occurs.
Intervention MeSH terms: Oxytocin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of Reverse Nordic Exercise on Vertical Jump in Youth Soccer Players
Condition: Strength
Study type: Interventional

Summary: 
      BACKGROUNDː The reverse nordic hamstring exercise is developed for the eccentric work of the
      rectus femoris. After performing Nordic exercise protocol (its original), the relationship
      between increased eccentric hamstring strength, improvements in sprint capacity and reduced
      incidence of injuries can be confirmed. The review of evidence, led us propose the
      relationship and the possible benefits that could exist in the performance of four weeks of
      reverse nordic exercise protocol and the vertical jump, measured with countermovement jump
      test (CMJ) on a platform of jump.

      METHODSː An open randomized controlled trial was conducted, with an intervention and control
      group, to which they were randomly assigned. The sample was made of 19 players from the San
      Antonio de Murcia Catholic University Team in the youth A category, aged between 16 and 18
      years old. The experimental group (n=10) performed the reverse nordic hamstring exercise
      protocol for four weeks, in addition to the usual training that they shared with the control
      group (n=9). Data collection for the CMJ test was done before starting the protocol and
      immediately after finishing it for all participants. Statistical analysis was carried out
      with the SPSS program.
    


Intervention name(s): Nordic Reverse Protocol
Intervention type(s): Procedure
Intervention description(s): The participant begins on their knees, with the trunk upright and fully aligned. At this moment, the soccer player slowly leans back, maintaining the starting position by means of a controlled flexion of the knees. This fall is executed at the lowest speed possible to maximize muscle load in the eccentric phase and reach the point of maximum flexion.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized Controlled Trial
Masking: Single (Investigator)
Primary purpose: Basic Science
Keywords: Soccer; Eccentric Force; Quadriceps; Reverse Nordic Hamstring Exercise; Vertical Jump
Thiocolchicoside Injection and Capsule in Treatment of Acute Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional
Phase: Phase 4

Summary: 
      To assess two regimens of thiocolchicoside injection and capsule in combination with either
      diclofenac or ibuprofen in patients with acute low back pain.
    


Intervention name(s): Thiocolchicoside
Intervention type(s): Drug
Primary purpose: Treatment
Sorafenib Dose Ramp-Up in Hepatocellular Carcinoma (HCC)
Condition: Hepatocellular Carcinoma
MeSH terms: Carcinoma; Carcinoma, Hepatocellular
Study type: Interventional
Phase: Phase 4

Summary: 
      Open-label study to evaluate the safety and tolerability of Sorafenib dose ramp-up (starting
      at a lower dose and then gradually increasing the dose) versus standard Sorafenib dosing in
      subjects with unresectable and/or metastatic hepatocellular carcinoma.
    

Detailed description: 
      This is an open-label study that investigates the impact of a dose ramp-up strategy for
      sorafenib in patients with HCC. Clinical trial and post-marketing data suggest that sorafenib
      dose reductions and discontinuations due to adverse events are common and limit the drug's
      effectiveness. It is our hypothesis that a dose escalation strategy for sorafenib will
      improve the tolerability and allow a greater percentage of patients to remain on drug. The
      primary end-point of the study is the total accumulated and median daily dose of sorafenib
      delivered at month 2 and 4.
    

Intervention name(s): Sorafenib Standard Dosing Regimen; Sorafenib Ramp-Up Regimen
Intervention type(s): Drug; Drug
Intervention description(s): Sorafenib 400 mg twice daily until wk 24 or end of treatment; 200 mg daily, Day 0-Day 13 200 mg twice daily, Day 14-Day 20 600 mg daily, Day 21-Day 27 400 mg twice daily, Day 28 until end of treatment400 mg twice daily
Other intervention name(s): Nexavar(Bay43-9006); Nexavar (Bay43-9006)
Intervention MeSH terms: Sorafenib
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Hepatocellular Carcinoma; HCC; Liver Cancer