bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Load Monitoring on Pilates Training
Condition: Pilates Method; Exercise
Study type: Interventional

Summary: 
      There has been an increasing awareness about the need to practice some physical activity,
      including several objectives, mainly as a preventive character. From this perspective, notice
      the use of the Pilates method as an instrument of therapeutic exercise for the protection and
      promotion of health. However, despite being popularly performed, there is still no scientific
      evidence on the standardization of the use of the method and its progression to an adequate
      prescription of physical training. The objective is monitoring the progression of loads of a
      12-week training among the basic, intermediate and advanced levels of the Pilates method
      through heart rate (HR), subjective exertion perception (PSE) and heart rate variability
      (HRV). In addition, analyzing the effect of the method on cardiorespiratory and autonomic
      parameters. 40 healthy men aged 18-36 will receive Pilates training for 12 weeks. After the
      initial assessment and familiarization with the method, the training period will begin
      totalizing 36 sessions for three months, where each class lasts approximately 1 hour. During
      the three months, the participants must pass through the three levels of training: Basic,
      Intermediate and Advanced. During each session, the investigators will initially collect:
      psychological questionnaire, visual analogue pain scale (VAS), and cardiorespiratory
      parameters (systolic and diastolic blood pressure, HR, respiratory rate and partial oxygen
      saturation). Throughout the session a heart rate meter will be positioned on the chest of the
      participant to capture HR, which will occur every five minutes together with the PSE
      illustrated in the model proposed by Borg. At the end of each session, the cardiorespiratory
      parameters will be collected again. In addition, cardiorespiratory parameters and HRV will be
      analyzed at baseline and after three months of training. In the case of HRV analysis, linear
      methods in the time and frequency domain will be verified. For the statistical analysis of
      the cardiorespiratory and autonomic parameters in the pre and post training moments will be
      used paired t test for normal data or Wilcoxon test for non normal data. For the analysis of
      the training load will be used the correlation of Pearson or Sperman according to normality.
      The definition of cutoff points for the HRV and PSE indices will be obtained by the ROC
      curve.
    


Intervention name(s): Pilates exercise
Intervention type(s): Other
Intervention description(s): Pilates methods exercises
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Exercise Movement Techniques; Exercise; Monitoring, Physiologic; Heart Rate; Autonomic Nervous System; Heart rate variability
The Renin-Aldosterone Axis in Postural Tachycardia Syndrome
Condition: Postural Orthostatic Tachycardia Syndrome (POTS)
MeSH terms: Postural Orthostatic Tachycardia Syndrome; Tachycardia; Syndrome
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine the role of the renin-angiotensin-aldosterone in
      the pathophysiology of postural tachycardia syndrome, and to provide an insight about the
      disease process in this disorder.
    


Intervention name(s): Angiotensin II
Intervention type(s): Drug
Intervention description(s): Angiotensin II infusion for 1 hour
Intervention MeSH terms: Angiotensin II; Giapreza; Angiotensinogen
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: POTS; Orthostatic intolerance
Comparison of Routine Endotracheal Intubation With McGrath Videolaryngoscope and Pentax AirwayScope
Condition: Intubation
Study type: Observational

Summary: 
      Recently many kinds of indirect videolaryngoscopes were developed. These videolaryngoscopes
      provide easier intubation, help intubation difficulty, are used good tool for education.
      McGrath Videolaryngoscope and Pentax AirwayScope are kinds of these videolaryngoscopes.

      The purpose of this study is to compare of routine endotracheal intubation with McGrath
      Videolaryngoscope and Pentax AirwayScope by means of providing better laryngeal view, easier
      and faster intubation.
    


Intervention name(s): Pentax Airwayscope; McGrath Videolaryngoscope
Intervention type(s): Device; Device
Intervention description(s): intubation using Pentax Airwayscope; intubation using McGrath Videolaryngoscope
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        patients scheduled for elective surgery requiring orotracheal intubation in our hospital
      
Keywords: videolaryngoscope
Influence of Beer on Gut Microbiota and Biochemical Outcomes: Alcohol Impact.
Condition: Healthy Volunteers
Study type: Interventional

Summary: 
      Our aim is to assess the effects of moderate consumption of beer and non-alcoholic beer on
      gut microbiota and biochemical biomarkers in healthy adults.
    


Intervention name(s): Beer with 5.20 % alcohol; Non-alcoholic beer with 0.45 % alcohol; Non-alcoholic beer with 0.00 % alcohol
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): 330 ml beer (5.20 % alcohol)/day during 4 weeks; 330 ml non-alcoholic beer (0.45 % alcohol)/day during 4 weeks; 330 ml nonalcoholic beer (0.00 % alcohol)/day during 4 weeks
Intervention MeSH terms: Ethanol
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: This is a three-arm parallel-group, randomized controlled study to evaluate the effect of consumption of beer with or without alcohol (5.20 %, 0.45 % and 0.00 %), during 4 weeks, on healthy individuals.
The study will focus on the effects of beer on microbiota and biochemical biomarkers in healthy human volunteers.
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Gut microbiota; Beer; Alcohol; Cardiovascular disease
Immunogenicity and Safety of Liquid Bivalent Oral Poliomyelitis Vaccine
Condition: Poliomyelitis
MeSH terms: Poliomyelitis
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study will be to evaluate whether a bivalent oral polio vaccine (bOPV)
      manufactured by Beijing Bio-Institute Biological Products Co., Ltd (BBIBP) has a similar
      immunogenicity profile to a WHO prequalified bOPV.
    

Detailed description: 
      BBIBP has been one of the two suppliers of trivalent oral polio vaccine (tOPV) in China since
      1985, with control of polio in China evidence of the effectiveness of its vaccine. The
      company plans to introduce a liquid formulation of bOPV (types 1 and 3) to meet increasing
      global demand with the phasing-out of tOPV. The proposed study is intended to provide data
      sufficient to obtain World Heath Organization (WHO) prequalification for the BBIBP bOPV, thus
      making the vaccine available to help meet global demand.

      Infants were enrolled and randomized prior to the birth dose of bOPV. The first dose of study
      vaccine was administered during the first two weeks of life and then co-administered with the
      primary Expanded Programme on Immunization (EPI) series vaccines in Kenya at 6, 10 and 14
      weeks of age. The Kenya EPI schedule includes the following additional vaccines:

        -  Bacille Calmette-Guérin Vaccine (BCG) at birth

        -  Diphtheria and Tetanus Toxoid with Whole Cell Pertussis, Haemophilus influenzae Type V
           vaccine (Hib), and Hepatitis B Vaccine (DTwPHibHep) at 6, 10, 14 weeks;

        -  Pneumococcal Conjugate vaccine (PCV) at 6, 10, 14 weeks

        -  Rotavirus vaccine (Rotarix) at 6, 10 weeks
    

Intervention name(s): BBIBP Bivalent Oral Poliomyelitis Vaccine Lot 1; BBIBP Bivalent Oral Poliomyelitis Vaccine Lot 2; BioFarma Bivalent Oral Poliomyelitis Vaccine
Intervention type(s): Biological; Biological; Biological
Intervention description(s): Each dose of bOPV (2 drops, 0.1 ml) contains attenuated Sabin strains of poliovirus serotypes 1 and 3, with at least 10^6 cell culture infectious dose 50% (CCID50)/dose and 10^5.8 CCID50/dose, respectively.; Each dose of bOPV (2 drops, 0.1 ml) contains types 1 and 3 attenuated polioviruses (Sabin), with at least 10^6 CCID50/dose and 10^5.8 CCID50/dose, respectively.; Each dose of the WHO prequalified Bio Farma bOPV (2 drops, 0.1 ml) contains attenuated Sabin strains of poliovirus serotypes 1 and 3, with at least 10^6 and 10^5.8 infective units per dose, respectively.
Other intervention name(s): Poliomyelitis (Live) Vaccine Type I Type III (Human Diploid Cell), Oral; Poliomyelitis (Live) Vaccine Type I Type III (Human Diploid Cell), Oral
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Efficacy of Sterol-Fortified Low Fat Soy Beverage on Cholesterol Metabolism, Inflammation and Oxidative Status in Humans - Study II
Condition: Hypercholesterolemia
MeSH terms: Hypercholesterolemia; Inflammation
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Hypercholesterolemia is a well-established risk factor for the development of
      atherosclerosis, a component of cardiovascular disease (CVD). The National Cholesterol
      Education Program advises the public to consume 2 g/day of plant sterols or stanols in
      addition to the Therapeutic Lifestyle Change Diet to lower elevated low-density lipoprotein
      (LDL) cholesterol levels. For foods to carry the FDA health claim label they must contain
      0.65 g of phytosterol ester or 1.7 g of phytostanol ester per serving. The study was a
      controlled diet, cross-over clinical investigation using a Latin square sequence. It
      consisted of two 29 d phases separated by a four week wash out interval. Subjects were
      randomized to one of two treatment arms: 1 % dairy milk or low-fat soy beverage providing
      1.95 g plant sterols/day.
    


Intervention name(s): plant sterol enriched soymilk; control dairy milk
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): plant sterol enriched soymilk; control dairy milk
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: plant sterols; diet; soymilk; cholesterol
Immediate-access Arteriovenous Versus Standard Arteriovenous Grafts in Hemodialysis Patients
Condition: Hemodialysis Access Failure
Study type: Interventional

Summary: 
      Arteriovenous fistulae (AVF) are considered the main access for hemodialysis (HD).
      Arteriovenous grafts (AVGs) are an alternative access modality in patients with exhausted
      native venous access. Immediate-access arteriovenous grafts (IAAVGs) is a new modality in
      which dialysis can be started immediately to avoid complications of central venous catheters.
    

Detailed description: 
      The study aimed to evaluate and compare patency rate and complications of standard
      arteriovenous grafts (SAVGs) and immediate-access arteriovenous grafts (IAAVGs) in end stage
      renal disease (ESRD) patients for one year after the intervention. Patients were randomly
      divided into two groups: SAVGs group and IAAVGs group. Patients with ESRD with no chance for
      native AVF were examined clinically and by duplex ultrasonography preoperatively. Follow up
      was for one year. Primary end points were the success rate, complications rate (hematoma,
      pseudo-aneurysm, graft site infection, systemic bacteremia), time of first cannulation.
      Secondary end points were primary and secondary patency within one year.
    

Intervention name(s): Arteriovenous Grafts
Intervention type(s): Procedure
Intervention description(s): Arteriovenous fistulae (AVF) are considered the main access for hemodialysis (HD). Arteriovenous grafts (AVGs) are an alternative access modality in patients with exhausted native venous access. Immediate-access arteriovenous grafts (IAAVGs) is a new modality in which dialysis can be started immediately to avoid complications of central venous catheters.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Bipolar Research Study Using MR Imaging
Condition: Bipolar Affective Disorder
MeSH terms: Bipolar Disorder; Mood Disorders
Study type: Observational

Summary: 
      In this proposal, the investigators will focus on subcortical gray and white matter
      structures commonly found to be abnormal in schizophrenia. Thus, the investigators will
      evaluate the volume and shape of the hippocampus, thalamus and basal ganglia, as well as
      measures of structural integrity of the corpus callosum and its various subregions.
    

Detailed description: 
      There are relatively few studies evaluating brain structure in bipolar disorder (BD), the
      results of which have been largely inconsistent, both in terms of what abnormalities are
      present in BD and whether they show any similar abnormalities to those found in
      schizophrenia. One possibility that might explain the varying degree of reported similarity
      in structural findings in schizophrenia and BD is that there might be effects of BPD
      diagnostic subtype associated with brain structure. One viewpoint that contrasts
      schizophrenia and BD considers psychotic (PBD) to differ from non-psychotic (NPBD) subtypes
      in terms of shared pathophysiology with schizophrenia. PBD has been reported as being of
      special interest, as it shares symptomatic overlap with schizophrenia, "runs in families",
      shares a chromosomal linkage to the 13q13-32 and 22q12 with schizophrenia, shows similar
      increases in dopamine receptor Bmax induced by [c-11] N-methylspiperone positron emission
      tomography and similar working memory impairments as in schizophrenia. If PBP and NPBP are
      associated with different forms of brain pathology, then merging the two entities into a
      single "bipolar group" might obscure relevant anatomic differences if these occur primarily
      in only one group. In this proposal, the investigators will focus on subcortical gray and
      white matter structures commonly found to be abnormal in schizophrenia. Thus, the
      investigators will evaluate the volume and shape of the hippocampus, thalamus and basal
      ganglia, as well as measures of structural integrity of the corpus callosum and its various
      subregions.
    

Intervention name(s): MRI scanning
Intervention type(s): Other
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Community Sample
      
Keywords: Bipolar Disorder; Magnetic Resonance Imaging (MRI) scanning
N-Acetyl Cysteine in Pathologic Skin Picking
Condition: Pathologic Skin Picking; Neurotic Excoriation; Psychogenic Excoriation; Dermatillomania
Study type: Interventional
Phase: Phase 2

Summary: 
      The goal of the proposed study is to evaluate the comparative efficacy of N-acetyl cysteine
      to placebo in pathologic skin picking. Thirty subjects with pathologic skin picking will
      receive 12 weeks of double-blind treatment with N-acetyl cysteine or matching placebo. The
      hypothesis to be tested is that N-acetyl cysteine will be more effective than placebo in
      patients with pathologic skin picking. The proposed study will provide needed data on the
      treatment of an often disabling disorder that currently lacks a clearly effective treatment.
    

Detailed description: 
      Pathologic skin picking involves repetitive, ritualistic, or impulsive picking of otherwise
      normal skin leading to tissue damage, personal distress, and impaired functioning. Although
      skin picking has been described in the medical literature for over one-hundred years, it
      remains a poorly understood psychiatric issue and often goes undiagnosed and untreated.

      Picking behavior does not by itself suggest a psychiatric disorder. Pathology exists in the
      focus, duration and extent of the behavior, as well as the reasons for picking, associated
      emotions, and resulting problems. Patients with PSP report thoughts of picking or impulses to
      pick that are irresistible, intrusive and/or senseless. These thoughts, impulses, or
      behaviors also cause marked distress for patients and significantly interfere with other
      activities. Unlike normal picking behavior, the pathologic form of skin picking is recurrent
      and usually results in noticeable skin damage.

      Thirty subjects with pathologic skin picking will receive 12 weeks of double-blind treatment
      with N-acetyl cysteine or matching placebo. The hypothesis to be tested is that N-acetyl
      cysteine will be more effective than placebo in patients with pathologic skin picking. The
      proposed study will provide needed data on the treatment of an often disabling disorder that
      currently lacks a clearly effective treatment.
    

Intervention name(s): N-Acetyl Cysteine; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Week 0 (Visit 1) - Week 3 (V2): 1200mg/day (600mg po qam and 600mg po qpm) Week 3 (V2) - Week 6 (V3): 2400mg/day (1200mg po qam and 1200mg po qpm) Week 6 (V4) - Week 12 (V5): 3000mg/day (1200mg po qam and 1800mg po qpm); Matching placebo capsules taken in same amount of pills as the active medication.
Other intervention name(s): NAC; Sugar pill
Intervention MeSH terms: Acetylcysteine; N-monoacetylcystine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: N-Acetyl Cysteine; Picking; Impulse Control Disorder; Obsessive Compulsive Disorder
The Effects of Dragon Fruit Consumption on Vascular Function.
Condition: Healthy Men and Women
Study type: Interventional

Summary: 
      Native to South America and South East Asia, the dragon fruit (pitaya) has become
      increasingly popular world-wide due to their vivid hue and bizarre structure. More
      importantly, their high levels of bioactive phytochemical betalains has sparked considerable
      scientific interest. Recent findings from in vitro and in vivo animal studies tentatively
      suggest that betalains may have ameliorative effects on vascular function. This will be a
      first randomised controlled trial aimed to explore the impact of dragon fruit consumption on
      blood pressure and other vascular parameters in healthy individuals. The study will feature a
      randomised, double-blinded, placebo-controlled and crossover design with flow-mediated
      dilatation (FMD) as primary outcome along with blood pressure and arterial stiffness as
      secondary outcomes. Cardiovascular biomarkers as well as relevant metabolites will also be
      determined from blood and urine samples collected from participants.
    


Intervention name(s): Dragon fruit juice drink; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Dragon fruit drink containing 24 g of freeze-dried dragon fruit powder dissolved in low nitrate water.; Drink with macro- and micro-nutrient matched against the intervention drink.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: vascular function; endothelial function; betalains; dragon fruit; pitaya
Efficacy of Pregabalin in Patients With Radicular Pain
Condition: Neuropathy; Radicular, Lumbar, Lumbosacral; Failed Back Surgery Syndrome; Spinal Stenosis; Herniated Disc
MeSH terms: Spinal Stenosis; Intervertebral Disc Displacement; Radiculopathy; Failed Back Surgery Syndrome
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study is to evaluate whether pregabalin is effective in reducing the pain
      in patients who present with radicular pain due to a herniated disc, spinal stenosis or
      failed back surgery syndrome.
    

Detailed description: 
      Although the efficacy of pregabalin has been demonstrated in several pain states and it is
      approved by the FDA for use in post herpetic neuralgia, diabetic neuropathy and fibromyalgia
      there are few studies of its efficacy in patients with radicular pain from herniated disc,
      spinal stenosis or failed back surgery syndrome. This study was conducted to evaluate the
      efficacy of pregabalin in these pain states.
    

Intervention name(s): Pregabalin; Sugar Pill
Intervention type(s): Drug; Drug
Intervention description(s): One pregabalin 75mg capsule will be prescribed twice daily for the first week of the study (150mg/day). For the subsequent 2 weeks, the dose will be increased to 2 pregabalin capsules twice a day (300mg/day). The total duration of the treatment will be 3 weeks.; One sugar pill will be prescribed twice daily for the first week of the study. For the subsequent 2 weeks, 2 placebo(sugar pills) capsules twice a day. The total duration of the treatment will be 3 weeks.
Other intervention name(s): Lyrica®, Pfizer NY, NY 10017; Placebo
Intervention MeSH terms: Pregabalin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Pregabalin; Radicular pain; Failed back surgery; Of greater than 3 months duration
ULTrasound Accelerated ThrombolysIs of PulMonAry Embolism
Condition: Submassive Pulmonary Embolism
MeSH terms: Pulmonary Embolism; Embolism
Study type: Interventional
Phase: Phase 3

Summary: 
      The ULTIMA study is intended to prove that in patients with pulmonary embolism and a right
      ventricular end diastolic diameter to left ventricular end diastolic diameter ratio ≥1 (RV/LV
      ratio) will benefit from treatment with ultrasound accelerated thrombolysis (rt-PA) as
      compared to unfractionated heparin anticoagulation. Specifically, at 24 hours the RV/LV ratio
      will be significantly reduced in the treatment arm compared to the control arm.
    


Intervention name(s): EkoSonic Endovascular System; Unfractionated heparin
Intervention type(s): Device; Drug
Intervention description(s): The EkoSonic Endovascular System will be used to deliver < 20 mg of rt-PA ( Actilyse) directly into the occlusive pulmonary thrombus.; Intravenous unfractionated heparin used for anticoagulation treatment
Intervention MeSH terms: Heparin; Calcium heparin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Pulmonary embolism; Pulmonary thromboembolism; anticoagulation; thrombolysis; ultrasound accelerated thrombolysis