bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Active Release Technique and Instrument Assisted Soft Tissue Mobilization in Patients With Migraine
Condition: Migraine Disorders
MeSH terms: Migraine Disorders
Study type: Interventional

Summary: 
      Rationale of this research is to evaluate the outcome of active release technique and
      Instrument assisted soft tissue mobilization on trigger points in subjects with Migraine. The
      significance of this study is to identify which technique is superior in alleviating the
      symptoms of migraine. This study will help gather evidence on the practice of incorporating
      trigger point therapy in the treatment of Migraine.
    

Detailed description: 
      Migraine is a neurological condition that typically causes painful headache attacks lasting
      from four to 72 hours that occur with additional symptoms, such as sensitivity to light,
      sound, smell, or touch. Migraines occur most frequently in the morning, especially upon
      waking. Migraines can be triggered by stress or hormones. Migraine attacks are debilitating
      and can hinder the day to day activities and productivity of the patient. The purpose of the
      study was to evaluate the effects of active release technique and instrument assisted soft
      tissue mobilization on trigger points. It was a randomized, controlled trial, conducted among
      migraine patients. Sample size was 54 by using Epitool software. Participants were randomly
      assigned to the intervention or control group after a baseline assessment with a lottery
      ticket and an opaque envelope.All participants in both groups were evaluated on baseline and
      post-intervention.
    

Intervention name(s): Active Release Technique; Instrument Assisted Soft Tissue Mobilization
Intervention type(s): Other; Other
Intervention description(s): active TrP was identified, and sustained and constant pressure was applied .for stretching of the SCM muscle, the patient performed contralateral lateral flexion and ipsilateral rotation of the head to achieve stretching, for trapezius the therapist performed lateral flexion of the neck.; The therapist applied IASTM strokes for 20 seconds parallel to muscle fibers, followed by strokes for 20 seconds perpendicular to muscle fibers with the tool held at a 45° to the skin. .
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants were randomly assigned to the A group or B group after a baseline assessment with a lottery ticket and an opaque envelope containing the same number of folded papers labeled &quot;Group A&quot; or &quot;Group B.&quot; Each participant took a piece of paper that identified their group and gave it to the researchers without seeing what was written. Participants were not notified which group was assigned to.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Trigger points,; Active release Technique,; IATSM
Effect of Cross Frequency tACS on Cognitive Control
Condition: Cognitive Control; Executive Function
Study type: Interventional

Summary: 
      Investigation of frequency specific transcranial alternating current stimulation on cognitive
      control signals in frontal cortex
    

Detailed description: 
      Previous evidence suggests that there are specific frequency bands associated with different
      aspects of cognitive control. In specific delta (2-4Hz) and beta (15-30Hz) are associated
      with increased levels of abstraction for learned rules; and theta (5-8Hz) and gamma (30-50Hz)
      has been associated with increased set-size or number of learned rules. Here we aim to find
      causal evidence in support of these previous correlational findings by applying
      cross-frequency transcranial alternating current stimulation (tACS) in the specific frequency
      bands previously shown to be task-relevant. In a crossover design, we stimulate subjects with
      either delta-beta or theta-gamma tACS during performance of a hierarchical cognitive control
      task that manipulates the level of abstraction and set-size of rules that must be learned in
      order to make the correct button press.
    

Intervention name(s): Theta-gamma tACS; Delta-beta tACS; Sham tACS
Intervention type(s): Device; Device; Device
Intervention description(s): NeuroConn technologies, direct current-stimulator plus; NeuroConn technologies, direct current-stimulator plus; NeuroConn technologies, direct current-stimulator plus
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Healthy participants will receive three waveforms of transcranial alternating current stimulation (tACS). Delta-beta, Theta-gamma, and Sham.
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: tACS; Cognitive Control; Executive Function
Zaleplon in HIV Patients With Depression
Condition: HIV/AIDS; Clinical Depression
MeSH terms: Depression; Depressive Disorder
Study type: Interventional
Phase: Phase 2

Summary: 
      In HIV positive patients with sleep onset insomnia and receiving pharmacologic treatment for
      comorbid depression, the proposed study aims to evaluate the impact of zaleplon on sleep
      measures determined by insomnia severity index (ISI) and Epworth sleepiness scale (ESS).
    

Detailed description: 
      An estimated >50% of HIV positive individuals report insomnia. Insomnia and other sleep
      disturbances negatively impact outcomes in this population by contributing to metabolic
      dysfunction, reducing quality of life, and impairing psychosocial functioning. Additionally,
      in HIV depressed populations, insomnia may hinder remission from clinical depression. To
      date, there have been no pharmacotherapeutic studies treating insomnia in this population,
      emphasizing the need to determine whether known hypnotic medications work as effectively in
      HIV positive patients, including those with comorbid depression. Non-benzodiazepine hypnotics
      represent an attractive pharmacotherapy for treatment of insomnia in a depressed population,
      as there are reduced side effects and abuse potential compared to classical benzodiazepines.
      Consequently, an open-label study evaluating zaleplon for insomnia in HIV positive patients
      with comorbid depression warrants further study.
    

Intervention name(s): Zaleplon
Intervention type(s): Drug
Intervention description(s): non-benzodiazepine hypnotic agent
Intervention MeSH terms: Zaleplon
Intervention model: Single Group Assignment
Intervention model description: 6-week open-label study evaluating zaleplon for insomnia in HIV positive patients with comorbid depression
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Insomnia; Zaleplon
Efficacy of Hippotherapy Simulator Exercise Program in Stroke Patients
Condition: Stroke
MeSH terms: Stroke
Study type: Interventional

Summary: 
      The aim of our study is to investigate the effects of hippotherapy simulator exercises in
      addition to the conventional rehabilitation program on the balance, postural control,
      mobility, functional capacity, and independence levels of stroke patients.
    

Detailed description: 
      Twenty-six 18- 65 years of patients with stroke were included in the study. Patients were
      divided into two groups as hippotherapy simulator group (HSG) (n = 13) and conventional
      exercise group (CEG) (n = 13). Patients were evaluated with Berg Balance Scale (BBS) for
      balance, Postural Assessment Scale for Stroke (PASS) for postural control, Rivermead Mobility
      Index (RMI), and Time Up- Go Test (TUG) for mobility, 2min. Walking Test (2mWT) for
      functional capacity and Barthel Index (BI) for the level of independence respectively before
      and after treatment.
    

Intervention name(s): Hippotherapy Simulator; Conventional Exercise
Intervention type(s): Other; Other
Intervention description(s): Patients in the hippotherapy simulator group received 30 sessions of treatment for 6 weeks, 5 days a week and 1 hour a day. 45 minutes of Neurodevelopmental treatment exercises and 15 minutes of hippotherapy simulation exercise program were applied to the participants in this group.; Patients in the conventionnal exercise group received 30 sessions of treatment for 6 weeks, 5 days a week and 1 hour a day. 60 minutes of Neurodevelopmental treatment exercises were applied to the participants in this group.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: One group received hippotherapy exercise, while the other group received conventional exercise.
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Hippotherapy; Cerebrovasculer disorders; Stroke Rehabilitation; Balance; Exercise
Long-term Treatment Study of MRA for Systemic Juvenile Idiopathic Arthritis (sJIA)
Condition: Systemic Juvenile Idiopathic Arthritis
MeSH terms: Arthritis; Arthritis, Juvenile
Study type: Interventional
Phase: Phase 3

Summary: 
      An open-label, extension, Phase III study to evaluate the long-term safety and efficacy of
      MRA in patients with sJIA who were participated in Studies MRA011JP or MRA316JP
    


Intervention name(s): MRA(Tocilizumab)
Intervention type(s): Drug
Intervention description(s): 8mg/kg/2weeks
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Evaluating Hearing Aid Service Delivery Models
Condition: Presbycusis; Aging; Hearing Loss
MeSH terms: Hearing Loss; Presbycusis
Study type: Interventional

Summary: 
      The purpose of this study is to compare the outcomes for two different hearing-aid delivery
      models. In one model, the audiologist selects and fits the hearing aid and, in the other
      model, the consumer does this directly.
    

Detailed description: 
      The objectives of this study were to determine efficacy of hearing aids in older adults using
      audiology best practices, to evaluate the efficacy of an alternative over-the-counter (OTC)
      intervention, and to examine the influence of purchase price on outcomes for both
      service-delivery models. The design of this study was a single-site, prospective,
      double-blind placebo-controlled randomized trial with three parallel branches: (a) audiology
      best practices (AB), (b) consumer decides OTC model (CD), and (c) placebo devices (P).
      Outcome measures were obtained after a typical 6-week trial period with follow-up 4-week
      AB-based trial for those initially assigned to CD and P groups.

      Older adults from the general community were recruited via newspaper and community flyers to
      participate at a university research clinic. Participants were adults, ages 55-79 years,with
      mild-to-moderate hearing loss. Intervention(s): All participants received the same
      highenddigital mini-behind-the-ear hearing aids fitted bilaterally.AB and P groups received
      best-practice services from audiologists; differing mainly in use of appropriate (AB) or
      placebo (P) hearing aid settings. CD participants self-selected their own pre-programmed
      hearing aids via an OTC model. Primary outcome measure was a 66-item self-report, Profile of
      Hearing Aid Performance/Benefit. Secondary outcome measure was the Connected Speech Test
      benefit.
    

Intervention name(s): hearing aid
Intervention type(s): Device
Intervention description(s): All subjects received hearing aids, some selected by audiologist, some selected by consumer, and some programmed as placebo devices.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Keywords: presbycusis; hearing aids
Safety and Efficacy of Varying Regimens of CANDIN for Treatment of Common Warts (Verruca Vulgaris)
Condition: Warts
MeSH terms: Warts
Study type: Interventional
Phase: Phase 2

Summary: 
      This is a placebo-controlled, double-blind (subject, Investigator, and site staff with the
      exception of unblinded dedicated staff to handle study medication), phase 2a study with 3
      dose cohorts, randomized (concealed) to CANDIN or placebo (3:1). Main study will be up to 20
      weeks (10 doses administered every other week) or until a subject has complete resolution of
      all injectable common warts. Subjects who cannot tolerate dosing every 2 weeks due to a local
      tolerance issue may be injected at 3-week intervals for up to 10 doses, increasing the length
      of the study to 29 weeks. Subjects will be followed for 4 months after final injection(s) for
      evidence of new or reoccurring warts and for safety evaluation.
    


Intervention name(s): CANDIN; Placebo
Intervention type(s): Biological; Other
Intervention description(s): Candida albicans Skin Test Antigen for Cellular Hypersensitivity; 0.9% Sodium Chloride Injection USP (non-preserved)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Verruca vulgaris; Common Warts
Desmopressin (DDAVP) in Patients With Colorectal Cancer and Rectal Bleeding
Condition: Colorectal Cancer; Rectal Bleeding
MeSH terms: Colorectal Neoplasms; Gastrointestinal Hemorrhage; Hemorrhage
Study type: Interventional
Phase: Phase 2

Summary: 
      The objective of this study is to find the maximum tolerated dose and preliminary efficacy of
      desmopressin as an haemostatic agent, when is administered to patients with colorectal cancer
      and rectal bleeding, before specific oncologic treatment with surgery and/or chemotherapy
      and/or radiotherapy.
    

Detailed description: 
      Colorectal cancer is the third cause of cancer in men and women, according to data recently
      published in the United Sates, and the third cause of death in the same population. Ninety
      percent (90%) of patients have symptoms at the time of diagnosis, being rectal bleeding the
      most frequent one (50% of cases). Bleeding, mainly mild or moderate, has no specific
      treatment, and during the staging of the disease, can not be controlled.

      Desmopressin, a synthetic analogue of vasopressin, is a selective agonist of the receptor V2
      of vasopressin, inducing, among others, an haemostatic effect. Interestingly, the expression
      of this receptor has been described in human gastrointestinal tract, including colon and
      rectum and in colorectal tumors. Moreover, desmopressin has shown a significant antitumor
      activity in preclinical murine models of colorectal cancer.

      This is a dose finding study, to investigate a new indication of desmopressin as an
      haemostatic agent in patients with colorectal cancer with mild to moderate rectal bleeding.
    

Intervention name(s): Desmopressin
Intervention type(s): Drug
Intervention description(s): Dose groups: Group 1: 0.25 µg/kg/day; Group 2: 0.25 µg/kg/12 hours; Group 3: 0.50 µg/kg/12 hours; Group 4: 1 µg/kg/day; Group 5: 1 µg/kg/12 hours; Group 6: 2 µg/kg/day.
All groups will receive desmopressin intravenously, in a 15-20 minutes infusion, one or two times a day. The administration will be repeated 24 hours after the first infusion.
Intervention MeSH terms: Deamino Arginine Vasopressin
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Safety and Efficacy Study of Doxycycline in Combination With Interferon-B-1a to Treat Multiple Sclerosis
Condition: Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Sclerosis
Study type: Interventional
Phase: Phase 4

Summary: 
      To evaluate the efficacy, safety, and tolerability of combination therapy with intramuscular
      interferon beta-1a and oral doxycycline, a potent inhibitor of matrix metalloproteinases, in
      patients with relapsing remitting multiple sclerosis (RRMS) having breakthrough disease
      activity.
    

Detailed description: 
      Eligible individuals were evaluated monthly for 3 months while taking intramuscular
      interferon beta-1a, 30 micrograms weekly, then monthly for 4 months while receiving
      intramuscular interferon beta-1a, 30 micrograms and oral doxycycline, 100 mg daily.
    

Intervention name(s): Interferon beta 1a, oral doxycycline
Intervention type(s): Drug
Intervention description(s): Patients took intramuscular interferon beta 1a, 30 micrograms, for 3 months then added oral doxycycline, 100 daily with the interferon for 4 months.
Other intervention name(s): Avonex
Intervention MeSH terms: Interferons; Interferon-beta; Interferon beta-1a; Doxycycline
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Deep Margin Elevation Vs Crown Lengthening
Condition: Endodontically Treated Teeth
MeSH terms: Tooth, Nonvital
Study type: Interventional

Summary: 
      The present clinical trial will be conducted to reject or accept the null hypothesis that in
      endodontically treated posterior teeth with deeply located proximal margins, will the Deep
      Margin Elevation will have better results from surgical crown lengthening in terms of
      biological criteria?
    


Intervention name(s): Deep Margin Elevation using resin composite; Surgical Crown Lengthening
Intervention type(s): Procedure; Procedure
Intervention description(s): After completion of the root canal treatment of the offended tooth and comprehensive evaluation of the obtained treatment, the randomly allocated patients will undergo deep margin elevation procedure where rubber dam isolation will be accomplished Followed by proper matricing and wedging ) followed by selective enamel etching for 10 seconds then universal adhesive application following the manufacturer instructions followed by application of flowable resin composite for the first 1 mm and light cured for 20 seconds according to the manufacturer recommendations followed by application of packable bulk fill composite to elevate the margins and light cured following the manufacturer instructions.; Participants in this group will undergo surgical crown lengthening in which an internal bevel incision will be done buccally and lingually followed by full thickness flap reflection using mucoperiosteal elevator, then interproximal bone removal will be done using end cutting bur to the planned position away from the margins by 3 mm. The flap will be displaced apically with apically positioned sutures. Postoperative instructions will be given to the patient aiming to control postsurgical complications including pain and swelling. Suture removal and assessment of the surgical site will be done after two weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Clinical Evaluation of Lapsed Contact Lens Wearers Who Are Re-fit Into Senofilcon A Contact Lenses
Condition: Lapsed Contact Lens Wear
Study type: Interventional

Summary: 
      This study is an open-label, multi-site study. The total number of subjects was 200. The
      duration of this study was approximately four weeks. The primary objective was to assess what
      percentage of lapsed contact wearers, who have discontinued use of their contact lenses for
      greater than six months can be successfully re-fit with senofilcon A, reusable 2-weekly
      replacement daily wear lenses (spherical and toric designs).
    


Intervention name(s): senofilcon A; senofilcon A for Astigmatism
Intervention type(s): Device; Device
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of Energy Density Over 5 Days in Preschool Children
Condition: Feeding Behavior
Study type: Interventional

Summary: 
      In this study, the investigators will vary the energy density of foods served during three
      5-day periods. There will be a baseline condition, and then a condition where the energy
      density of food is lower and a condition where the energy density of food is higher. The
      primary aim is to determine the effect of varying the energy density of foods served over 5
      days on energy intake in preschool children. It is hypothesized that mean daily energy intake
      will be greater when children are served higher energy dense foods over 5 days than when
      served lower energy dense foods over the same period. Additionally, it is hypothesized that
      daily energy intake in the conditions with higher and lower energy densities will begin to
      converge across the 5-day period.
    


Intervention name(s): Food Energy Density
Intervention type(s): Other
Intervention description(s): Food Energy density manipulated
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Nutritional Status Of Under-Six Children: Epidemiology Study (NUTRI-STAT)
Condition: Children Behavior About Nutrition
Study type: Observational

Summary: 
      This study permit to evaluate the characteristics of children in third year of preschool,
      during a year, in 16 schools in Thionville (north-eastern France) by the way of the annual
      medical visit.The aim of the study is to describe the nutritional status of children
      under-six years of age: underweight, overweight, and obesity considering the sex. .
    

Detailed description: 
      For several decades the eating behavior has been changing. That note is obviously more true
      for children, with the arrival of new recipes, not really healthier for all. This study
      permit to evaluate the characteristics of children in third year of preschool, during a year,
      in 16 schools in Thionville (north-eastern France) by the way of the annual medical visit.
      The aim of the research is to estimate the healthy weight corresponding with a height
      considering the gender.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Children in third year of preschool in one of the 16 schools in Thionville, Lorraine,
        FRANCE
Perioperative Thoracotomy Analgesia; Different Analgesic Modalities
Condition: Analgesia
MeSH terms: Agnosia
Study type: Interventional

Summary: 
      the study aim is to compare the analgesic effect of thoracic epidural versus serratus plane
      block versus erector spinae block in thoracic surgeries
    

Detailed description: 
      comparing the analgesic effect of thoracic epidural versus serratus plane block versus
      erector spinae block in thoracic surgeries regarding pain control and possible side effects
    

Intervention name(s): serratus anterior block; thoracic epidural; erector spinae block
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): ultrasound guided block; thoracic epidural; ultrasound guided block
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention