Effect of High-intensity Intermittent Sprinting on Appetite Control on Obese Volunteers
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional

Summary: 
      Several studies have shown that high intensity intermittent sprints (HIIS) are more effective
      than moderate intensity continuous cycling (MICC) in reducing fat mass and improving insulin
      resistance in normal weight individuals. Changes in the appetite-regulatory system in
      response to exercise are likely to explain, at least partially, the better outcome observed
      after HIIS. Unfortunately, there are no studies comparing the impact of different types of
      acute aerobic exercise on the release of appetite-regulating hormones, subjective feelings of
      appetite and subsequent energy intake (EI).

      The primary objective of this study is to investigate the effects of acute isocaloric bouts
      of HIIT and MICC or a short duration sprint, in comparison with a resting control condition,
      on the postprandial release of appetite-regulating hormones, subjective feelings of appetite
      and subsequent EI in obese individuals. The investigators hypothesize that an isocaloric
      session of HIIS will result in a better short-term appetite control compared with MICC, by
      reducing hunger feelings and subsequent food intake more than MICC and by inducing a larger
      increase in the release of satiety gut peptides compared with the MICC.
    

Detailed description: 
      This will be a randomised cross-over study with four legs. Participants will act as their own
      controls and will be assigned to the four experimental conditions (resting, HIIS, MICC and
      SDS), 1 week apart, in a counter-balanced order.

      Participants will be asked to come to the Unit five times: one preliminary session and four
      experimental conditions (resting, HIIS and MICC isocaloric sessions and SDS). In the
      preliminary session, anthropometric data (weight and height) will be collected and a maximal
      fitness test performed, using a cycle ergometer.

      For the four experimental conditions, participants will be asked to arrive at approximately
      8.00, having fasted for at least 10 hours, and a cannula will be inserted into an antecubital
      vein. Two fasting blood samples will be taken and a standard breakfast offered. After that,
      serial blood samples will be taken at regular intervals for a period of 3h.

      Participants will be asked to rate their subjective feelings of hunger and fullness using
      visual analogue scales (VAS) throughout each study morning at different time points. Three
      hours after breakfast, participants will be placed in individual rooms, presented with a
      standardized lunch and instructed to rate the taste and palatability of the food presented.
    

Intervention name(s): resting - control; Moderate intensity exercise; High intensity intermittent training; Short sprint
Intervention type(s): Behavioral; Behavioral; Behavioral; Behavioral
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Obesity; exercise; appetite; hunger; satiety; food intake