Fluoride Varnish X Glass Ionomer Sealant on Cervical Dentin Hypersensitivity
Condition: Dentin Hypersensitivity; Dentin Sensitivity
MeSH terms: Dentin Sensitivity; Hypersensitivity
Study type: Interventional
Phase: Phase 3

Summary: 
      Dentin hypersensitivity (DH) can be defined as acute, short-duration pain from open dentin
      tubules in exposed dentin. The symptom of DH is subjective and varies from patient to patient
      and may present as mild discomfort or as a high-intensity pain, which can affect the
      individual's quality of life, interfering with their eating and hygiene habits. One approach
      to treatment would be the use of agents that chemically desensitize sensory nerves, blocking
      the transmission of nerve stimuli to the central nervous system.

      The effectiveness of desensitizing treatments is influenced by several factors present in the
      oral cavity, which can contribute to a greater effect of these agents but can also be
      responsible for removing them from the dental surface. To date, studies have been carried out
      in the short term, not exceeding an average period of 12 weeks, so there is no consensus on
      the technique or agent that will guarantee the most effective and lasting effect against DH,
      not even the ideal period for reapplication. Thus, more studies are needed to assess the
      clinical behavior of desensitizing products on the market, especially the most recent
      releases. Therefore, the aim of this study was to clinically compare the effectiveness of
      different office treatments for DH, being ClinproTM White Varnish, ClinproTM XT Varnish, and
      a control group (placebo) through pain assessment with the Visual Analog Scale (VAS), after
      stimulation with air from the triple syringe.
    

Detailed description: 
      This study compares the effectiveness of two in-office treatment for dentin hypersensitivity:
      G1:ClinproTM White Varnish, G2:ClinproTM XT Varnish, and a G3:placebo (where the application
      of a product was only simulated). Recruitment of the 121 volunteers were based on their
      self-reported complaint of dentin hypersensitivity, which confirmed with the use of an air
      blast from a triple syringe. Then, he/she showed in the VAS scale (which varies from 0=no
      pain to 10=the worst pain possible) the value that best describes the pain sensation. The
      subjects that present at least one tooth with a value of 4 and above in the VAS scale (if
      more than one hypersensitive tooth was present, the mean VAS values obtained were used, for
      each patient) was randomly allocated into the experimental groups. Two weeks before the study
      started, the volunteers went through a wash out period, where they used only the oral hygiene
      products donated by the researchers, which were used up to the end of the study. The
      in-office treatments were performed after prophylaxis, according to the manufacturer´s
      instructions, by one trained researcher, which was blind to the treatments. DH evaluation was
      performed 15 min after the application of the treatments, by a different researcher, which
      also blind to the treatment, and which used the same methodology described early for the
      detection of initial pain. The volunteers were recalled for the DH evaluation after one and
      four weeks of the treatments. DH evaluation was also performed after 12 and 24 weeks of the
      treatments, except in the placebo group, which received the proper DH treatment after the
      first four weeks of the study. Data was analyzed with the appropriate statistical methods
      (α=0.05).
    

Intervention name(s): Fluoride Varnish; Glass Ionomer Sealant; Placebo Group
Intervention type(s): Drug; Drug; Other
Intervention description(s): Following the manufacturer's recommendations, it was not necessary to moisten or dry the treated surface beforehand or afterwards. The product was dispensed and manipulated for 15 s until a homogeneous mixture was obtained, applied with a micro brush, flowing into interproximal areas, and quickly adhering to the tooth surface in the presence of saliva.; Following the manufacturer's recommendations, prophylaxis and prior drying of the treated surface was carried out, the product was also dispensed and manipulated for 15 s until a homogeneous mixture was obtained, applied with a micro brush and light-cured for 20 s.; 4 weeks after the simulation of the treatment application, participants in the placebo group received DH treatment with the product that had the best effect in the first 4 weeks.
Other intervention name(s): ClinproTM White Varnish; ClinproTM XT Varnish; Resin-modified Glass Ionomer Sealant
Intervention MeSH terms: Fluorides; Fluorides, Topical
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The present study is a parallel, randomized, triple blind clinical trial.
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Dentin hypersensitivity; Dentin sensitivity; Hypersensitivity; Fluorides; Sodium fluoride; Glass ionomer sealant; Desensitizing treatment; Glass ionomer cement