bioihbjkbjnl/mcl2 huggingface dataset:
Effect of Cranberry Juice on Endothelial Function
Condition: Coronary Artery Disease
MeSH terms: Coronary Artery Disease; Myocardial Ischemia; Coronary Disease
Study type: Interventional

Summary: 
      A pilot study of 15 subjects will be completed to determine whether acute consumption of
      cranberry juice has an effect on endothelial function. We will then complete a randomized,
      double blind, placebo controlled crossover study designed to investigate the effects of
      cranberry juice consumption on endothelial function. Participants (n=40) will drink 480 ml of
      double strength cranberry juice or a similar appearing and tasting placebo per day for four
      weeks. After a two week rest period, they will cross over to the other beverage. We will
      examine endothelial function before and after each of the two treatment periods. The study
      will provide information about the chronic vascular effects of cranberry juice.
    


Intervention name(s): Cranberry juice
Intervention type(s): Dietary Supplement
Intervention description(s): 480 ml of double strength cranberry juice daily for four weeks
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Intravenous Mepolizumab In Subjects With Hypereosinophilic Syndromes (HES)
Condition: Hypereosinophilia; Hypereosinophilic Syndrome
MeSH terms: Hypereosinophilic Syndrome; Eosinophilia; Syndrome
Study type: Interventional
Phase: Phase 3

Summary: 
      Hypereosinophilic syndrome (HES) is a rare disease with broad clinical signs and symptoms
      which is diagnosed based on a persistent blood eosinophil count of greater than 1500 cells,
      various end-organ damages (including skin, heart, lung, nervous system and digestive system
      etc.), and with exclusion of known secondary causes of hypereosinophilia.

      HES has a high morbidity/mortality rate. The major treatment of HES has been systemic
      corticosteroid and other chemotherapeutic drugs (for example, hydroxyurea and interferon)
      with the intention to lower eosinophil counts and therefore to slow down the progression of
      disease. Even though corticosteroid and other therapies can effectively reduce eosinophilia
      in some patients, some may eventually become nonresponsive and intolerable to the amount of
      side effects of the long-term therapy with these medications.

      Mepolizumab is a humanized monoclonal antibody that binds specifically to human interleukin 5
      (hIL-5) and inhibits its activity. Previous human experience has shown it has been effective
      in reducing blood eosinophilia in atopic and HES patients and has alleviated some HES
      clinical signs and symptoms. This study intends to further evaluate the
      corticosteroid-sparing and clinical benefit of mepolizumab in HES.
    

Detailed description: 
      A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group Phase III Study
      to Evaluate Corticosteroid-reduction and -sparing effects of Mepolizumab 750 mg intravenously
      in Subjects with Hypereosinophilic Syndromes (HES) and to evaluate the Efficacy and Safety of
      Mepolizumab in controlling the Clinical Signs and Symptoms of HES over Nine Months
    

Intervention name(s): mepolizumab
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Hypereosinophilic Syndrome Hypereosinophilia; mepolizumab; anti IL-5
Optimizing Parameters for Long-pulsed Nd:YAG Laser for Reducing Hair Shaft Diameter
Condition: Androgenetic Alopecia; Hair Loss/Baldness
MeSH terms: Alopecia
Study type: Interventional

Summary: 
      This study evaluates the optimizing parameters of long pulse Nd:YAG Laser for reducing the
      size of hair shaft diameter of the donor for hair transplantation. All participants will
      receive long-pulsed Nd-YAG laser treatments with three different parameters at the occipital
      area.
    

Detailed description: 
      Since the beginning of hair transplantation era, hair transplant technique has been greatly
      improved to achieve the best natural looking of hairline and hair density. Most Asians tend
      to have large size of hair shaft at the donor area, which often cause unnatural look of the
      hairline at the frontal area after hair transplantation due to the contrast between the
      transplanted hair and the original hair.

      The idea of reducing the size of the hair shaft in the certain part of donor area before
      being transplanted to the frontal hairline becomes appealing. This transection is being
      practiced extensively in the field of cosmetic medicine by using long-pulsed
      Neodymium-Doped:Yttrium Aluminum Gamet (Nd:YAG), a laser treatment for permanent hair removal
      and vascular lesions.
    

Intervention name(s): Long-pulsed, 1064nm Nd-YAG laser
Intervention type(s): Device
Intervention description(s): This long-pulsed Nd-YAG laser is commonly used for laser hair removal and vascular lesions, but in this study it is used to reduce the size of the hair shaft at the occipital area.
Intervention model: Single Group Assignment
Intervention model description: This is a pilot study. We plan to enroll 15 participants who requires to do hair transplantation or normal participants who are eligible for the study.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: hair transplant; hairline; laser hair removal
Long Term Effects of an Inpatient Pulmonary Rehabilitation Program in Patients With Pulmonary Fibrosis
Condition: Idiopathic Pulmonary Fibrosis
MeSH terms: Pulmonary Fibrosis; Idiopathic Pulmonary Fibrosis; Fibrosis
Study type: Interventional

Summary: 
      There is evidence that an inpatient pulmonary rehabilitation of 3 weeks improves exercise
      capacity and quality of life in patients with idiopathic pulmonary fibrosis. However, there
      are no data available regarding long-term effects of this multimodal program. The aim of this
      study is to investigate the long-term impact of a rehabilitation program 3 month after
      finishing on exercise capacity and physical activity.
    


Intervention name(s): Inpatient Rehabilitation
Intervention type(s): Procedure
Intervention description(s): Rehabilitation program in "Schoen Klinik Berchtesgadener Land"
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: pulmonary fibrosis; interstitial lung disease; pulmonary rehabilitation; exercise capacity; physical activity; quality of life
Attention Control Training for the Prevention of PTSD in Firefighters
Condition: PTSD
MeSH terms: Stress Disorders, Post-Traumatic
Study type: Interventional

Summary: 
      The study aimed to examine the effect of Attention Control Training (ACT) intervention on
      reducing PTSD symptoms in firefighters. The study was a randomized controlled trial carried
      out in Kunming, China, and involved the recruitment of 180 active firefighters as
      participants. The intervention lasted for an 8-week duration, during which participants
      participated in ACT exercises delivered through a smartphone application.
    


Intervention name(s): Attention Control Training
Intervention type(s): Behavioral
Intervention description(s): Mobile app-based attention control training is an effective training method that can help people improve their ability to control attention. It is generally recommended to undergo 4 weeks of training, with 3-4 sessions per week and one day between each session. The specific operational method of this training may vary depending on different applications, but generally, training is presented in the form of a series of tasks. These tasks may involve aspects such as focusing attention, inhibiting interference, and reacting quickly.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: PTSD; Attention Control Training
Efficacy of 177-Lu-DOTA 0, Tyr 3 Octreotate
Condition: Neuroendocrine Tumors
MeSH terms: Neuroendocrine Tumors
Study type: Interventional

Summary: 
      Well-differentiated neuroendocrine tumors (WDNETs) are uncommon neoplasms with an increasing
      number of new cases reported in the annual statistics of the Instituto Nacional de
      Cancerología (INC). The majority are advanced-stage presentations with limited chances of a
      complete surgical resection of the primary tumor, a clinical scenario where medical treatment
      options are also limited. In view of the characteristically defined expression of peptide
      receptors in WDNETs, radioactive molecular probes to target specific cellular receptors have
      been designed using radioisotopes with short range of penetration in tissues. We have
      designed a one-arm phase II prospective sequential clinical trial to assess the therapeutic
      efficacy of 177-Lu-[DOTA 0, Tyr 3] octreotate (177-Lu- DOTATATE) applied intravenously in
      three separate doses to patients with inoperable progressive WDNET. Selected patients
      matching inclusion criteria will be enrolled at the INC's Section of Endocrinology. Tumor
      response, treatment safety (side effects) and survival will be appraised. Data from clinical,
      biochemical and imaging follow-up will be periodically registered during treatment and until
      two years after the last infusion of 177Lu- DOTATATE. This phase II trial is justified
      because despite the fact that many preclinical and clinical studies have showed the potential
      usefulness of this novel palliative approach to treat patients with advanced-stage WDNETs
      there is a paucity of vigorous results to establish its efficacy as first-line treatment.
    

Detailed description: 
      The Investigators have designed a one-arm phase II prospective sequential clinical trial to
      assess the therapeutic efficacy of 177-Lu-[DOTA 0, Tyr 3] octreotate (177-Lu- DOTATATE)
      applied intravenously in three separate doses to patients with inoperable progressive WDNET.
    

Intervention name(s): [177Lu] DOTA-TATE
Intervention type(s): Radiation
Intervention description(s): We have designed a one-arm phase II prospective sequential clinical trial to assess the therapeutic efficacy of 177-Lu-[DOTA 0, Tyr 3] octreotate (177-Lu- DOTATATE) applied intravenously in three separate doses to patients with inoperable progressive WDNET.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Neuroendocrine Tumors; Lutetium; Treatment Outcome
New Validated Recipes for Double-blind Placebo-controlled Low Dose Food Challenges
Condition: Allergy
MeSH terms: Hypersensitivity
Study type: Interventional

Summary: 
      This study aimed to validate new recipes for cow's milk, hen's egg, soy, cod and wheat, to be
      used in blinded low-dose food challenges.
    


Intervention name(s): Elemental E028 with added food allergens; Elemental E028
Intervention type(s): Other; Other
Intervention description(s): Test materials containing liquid vehicle (Elemental E028)with added food allergens (active); Elemental E028 with no added food allergens
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Diagnostic
Keywords: double-blind placebo-controlled food challenges; food allergy; food hypersensitivity; triangle test; validated recipes
TeleRehabilitation in Hypertension
Condition: Hypertension; Pre-hypertension; Healthy
MeSH terms: Hypertension; Prehypertension
Study type: Interventional

Summary: 
      The purpose of this RCT which will be performed in 60 healthy adults is I. To assess the
      training effects of 8 weeks of isometric handgrip exercise on BP; and to test whether it
      yields at least similar effects on BP compared to current exercise recommendations.

      II. To assess whether isometric handgrip training yields larger BP reductions beyond the
      supervised training period at 6 months of follow-up.

      III. To determine whether changes in BP following acute exercise and chronic training can be
      explained by changes in important physiological mechanisms known to mediate or to be
      associated with BP?
    


Intervention name(s): Isometric handgrip exercise; Aerobic endurance training
Intervention type(s): Other; Other
Intervention description(s): Participants have to perform 4 x 2 minute contractions with alternating hands, separated with 1 minute rest period using a ZonaHealth device;; To perform 150 minutes extra/week at moderate aerobic intensity
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Safety and Efficacy of Suvorexant (MK-4305) for the Treatment of Insomnia in Participants With Alzheimer's Disease (MK-4305-061)
Condition: Sleep Initiation and Maintenance Disorders; Alzheimer Disease
MeSH terms: Alzheimer Disease; Sleep Initiation and Maintenance Disorders
Study type: Interventional
Phase: Phase 3

Summary: 
      This study aims to examine the safety and efficacy of suvorexant (MK-4305) to improve sleep
      in individuals with Alzheimer's disease (AD). The primary hypothesis for the study is that
      suvorexant is superior to placebo in improving insomnia as measured by change from baseline
      in polysomnography (PSG)-derived total sleep time (TST) at Week 4.
    


Intervention name(s): Suvorexant; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 10 mg tablet (may be increased to 20 mg tablet); Placebo to suvorexant
Other intervention name(s): MK-4305
Intervention MeSH terms: Suvorexant
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Early Retinal Nerve Fiber Layer Change of Ethambutol Optic Neuropathy by Optical Coherence Tomography
Condition: Primary Lung Tuberculosis
MeSH terms: Tuberculosis; Tuberculosis, Pulmonary
Study type: Observational

Summary: 
      Ethambutol is widely used as first-line drug, but has serious side effect of optic
      neuropathy. As previously reported, incidence of ethambutol optic neuropathy is about 1~2%,
      there was considerable screening efforts and medical cost is increasing. However, there is no
      effective treatment of ethambutol optic neuropathy or no definite preventable measure.
      Moreover, multi-drug resistance tuberculosis or extensively drug resistance tuberculosis is
      emerging, more toxic secondary drug is used in the long-term.

      It is known that retinal nerve fiber layer is increased early stage in ethambutol optic
      neuropathy. So we decide to evaluate the retinal nerve fiber layer thickness measured by
      optical coherence tomography in longitudinal manner.
    


Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        patients who diagnosed with primary lung tuberculosis
      
Keywords: Retinal Nerve Fiber Layer Thickness, Optical Coherence Tomography, Ethambutol optic neuropathy
Ocular Findings of Polycystic Ovary Syndrome
Condition: Polycystic Ovary Syndrome
MeSH terms: Polycystic Ovary Syndrome; Syndrome
Study type: Observational

Summary: 
      Purpose: This study aimed to compare the ocular surface disease test results, anterior
      segment parameters, and ocular response analyzer (ORA) findings of polycystic ovary syndrome
      (PCOS) patients with those of healthy reproductive age female controls.
    


Intervention name(s): Observation
Intervention type(s): Other
Intervention description(s): Ocular Findings Observations
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        This was a prospective, case-control study in which 23 premenopausal patients with PCOS
        diagnoses and 15 non-pregnant healthy control subjects were included.
A Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Study Of PF-06700841, With Bioavailability/Food Effect Investigation
Condition: Plaque Psoriasis
MeSH terms: Psoriasis
Study type: Interventional
Phase: Phase 1

Summary: 
      The main purpose of the study is to determine if PF-06700841 is safe and well tolerated when
      administered to humans. A secondary purpose is to assess what the body does to PF-06700841
      and to assess what PF-06700841 does to the body when given as single and multiple doses. The
      pharmacokinetic properties of different forms of PF-06700841 may be studied (tablet and
      solution/suspension forms).
    


Intervention name(s): PF-06700841 oral solution/suspension; Placebo; PF-06700841 tablet
Intervention type(s): Drug; Other; Drug
Intervention description(s): Oral solution or suspension of study drug PF-06700841 (once daily or twice daily during multiple dosing periods); Matching placebo given during the single ascending and multiple dose periods; PF-06700841 tablet formulation administered during the bioavailability / food effect investigation
Intervention MeSH terms: PF-06700841
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Neurophysiological Attention Test (NAT) for Objective Assessment of Adult ADHD
Condition: Attention Deficit Hyperactivity Disorder
MeSH terms: Attention Deficit Disorder with Hyperactivity
Study type: Observational

Summary: 
      The purpose of this study is to refine a new assessment tool for Attention
      Deficit/Hyperactivity Disorder (ADHD) and then to test its validity (i.e. ability to
      discriminate between individuals with ADHD and healthy controls.
    

Detailed description: 
      The purpose of this study is to build upon the success the novel approach and software for
      analyzing electroencephalography (EEG) data to identify biomarkers of ADHD in adults by
      further refining the method. Then to test the ability of this new assessment tool to
      differentiate between adults with ADHD and healthy controls by comparing the classification
      accuracy of the metrics from the new tool to the classification accuracy of existing
      behavioral tests for ADHD.
    

Intervention name(s): NAT electroencephalography (EEG) test
Intervention type(s): Other
Intervention description(s): Individuals in both groups are asked to perform standard behavioral tests and an electroencephalography (EEG) test.
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Adults with Attention Deficit Hyperactivity Disorder (ADHD) from local clinics, clinicians,
        ADHD community resources in the area of each of the three participating Universities (UCLA,
        UCB, OHSU)
      
Keywords: Electroencephalography; Attention
A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome Patients
Condition: Treatment for Basal Cell Carcinomas (BCCs) in Gorlin Syndrome Patients
MeSH terms: Carcinoma; Carcinoma, Basal Cell; Basal Cell Nevus Syndrome; Syndrome
Study type: Interventional
Phase: Phase 2

Summary: 
      Part I was a double-blind, randomized, vehicle-controlled Proof of Concept (PoC) study to
      evaluate the safety, local tolerability, pharmacokinetics and pharmacodynamics of multiple
      topical administrations of LDE225 (a specific Smoothened inhibitor) on skin basal cell
      carcinomas in Gorlin's syndrome patients.

      Following a 21-day screening period, patients were exposed to multiple doses of topically
      applied LDE225 twice daily for 4 weeks in a double-blind manner. The patients returned weekly
      for visits where each BCC was clinically evaluated and digital photographs taken. Local
      safety and tolerability was also assessed. After the last application of treatment, biopsies
      were taken from treated (both vehicle and LDE225) BCCs (three per patient) for histology,
      biomarker evaluation and for pharmacokinetics (skin exposure). In addition, a biopsy from
      LDE225-treated uninvolved perilesional skin was taken for pharmacokinetic evaluation. In
      total, 4 biopsies were taken: 2 for histology and biomarker and 2 for PK.

      Part II of this study consisted of a 21-day screening period, a baseline period (directly
      before commencing the treatment period) and a treatment period of 6 or 9 weeks, depending on
      randomization. A clinical assessment was performed on site on the last treatment day and if a
      full clinical response had been observed, approximately 3 weeks after the last treatment an
      excision of the BCC(s) would have been performed. The study completion visit occurred either
      1 week after the excision (when this visit was planned) or 1 week after the last treatment.
      For a subset of patients, skin biopsies were collected on the last treatment day and an
      excision of a BCC was also performed at that same visit.
    


Intervention name(s): Vehicle; LDE225 0.25%; LDE225 0.75%
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Placebo cream
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Basal Cell Carcinoma; Gorlin Syndrome,; Gorlin-Goltz Syndrome,; Basal Cell Nevus Syndrome,; Nevoid Basal Cell Carcinoma Syndrome,; Basal Cell Carcinoma Nevus Syndrome
Olmesartan in Essential Hypertension
Condition: Essential Hypertension
MeSH terms: Hypertension; Essential Hypertension
Study type: Interventional
Phase: Phase 3

Summary: 
      To test the efficacy and safety of olmesartan in patients with essential hypertension.
    


Intervention name(s): placebo; olmesartan medoxomil; olmesartan medoxomil oral tablets, hydrochlorothiazide oral tablets
Intervention type(s): Other; Drug; Drug
Intervention description(s): Placebo oral tablets for 2 weeks; olmesartan medoxomil oral tablets for 8 weeks; olmesartan medoxomil oral tablets,or olmesartan medoxomil oral tablets + hydrochlorothiazide oral tablets
Intervention MeSH terms: Hydrochlorothiazide; Olmesartan; Olmesartan Medoxomil
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
The Effect of a Healthy Snack on Body Weight and Composition
Condition: Overweight
MeSH terms: Overweight; Body Weight
Study type: Interventional

Summary: 
      The results from this study may help to explain if incorporating mixed nuts in a reduced
      calorie diet will lead to weight loss.
    

Detailed description: 
      This study will compare two energy reduced diets; one diet will include one serving of mixed
      nuts (1.5oz) per day, while the other diet will include an equal amount of calories from a
      carbohydrate source, such as a pretzel snack. All subjects will receive a dietary plan that
      reduces their usual intake by 500kcal/day with the same percentage of fat, protein and
      carbohydrates for the first 12 weeks followed a diet with their usual intake for 12 weeks
      without nuts or pretzels.
    

Intervention name(s): Mixed Tree Nuts; Pretzels
Intervention type(s): Other; Other
Intervention description(s): Individuals on a hypo caloric weight loss dietary plan supplemented with 1.5oz mixed tree nuts; Individuals on a hypo caloric weight loss dietary plan supplemented with 1.5oz pretzels
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized Clinical Trial
Masking: None (Open Label)
Primary purpose: Other