bioihbjkbjnl/mcl2 huggingface dataset:
Success Rates for Management of Separated Instruments
Condition: Teeth, Endodontically-Treated
MeSH terms: Tooth, Nonvital
Study type: Interventional

Summary: 
      The study compares the prognosis of cases of Separated Instruments in Canals With Type II
      Vertucci's Classification treated with conservative approach
    

Detailed description: 
      Teeth with Type II Vertucci root canal configuration are having more incidence of instruments
      separation due the presence of an S-type (Double curve). The aim of this study is to compare
      the outcome of minimally invasive approach (MIA), retaining the separated in one root canal,
      cleaning and shaping of portals of entry of the two canals and portal of exit of both canals
      through the other patent canal, in comparison to the outcome of retrieval of the broken
      instrument by ultrasonics retrieval techniques (URT)
    

Intervention name(s): Endodontic retreatment
Intervention type(s): Procedure
Intervention description(s): retreatment of the patent root canal only without attempt to retrieve the separated instrument
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Evaluation of Patients With Statin Myopathy Using an N of 1 Trial Design
Condition: Statin Myopathy
MeSH terms: Muscular Diseases
Study type: Interventional

Summary: 
      This study consists of a series of prospective, randomized placebo-controlled n of 1 trials
      to objectively evaluate the reproducibility of subjective and objective symptoms among
      patients with a history of statin-related myopathy.
    


Intervention name(s): Individual-specific statin causing myopathy; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Individual-specific statin causing myopathy vs. placebo; Placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Other
Decision Aid to Technologically Enhance Shared Decision Making
Condition: Colorectal Cancer
MeSH terms: Colorectal Neoplasms
Study type: Interventional

Summary: 
      Physicians face a challenge in promoting colorectal cancer screening (CRCS) in the face of
      multiple competing demands. A decision aid (DA) that clarifies patient preferences and
      improves decision quality could aid shared decision making (SDM) and be effective at
      increasing CRCS rates. However, exactly how such DA improves SDM is not clear. This 4-year
      R01 study funded by the National Cancer Institute seeks to provide detailed understanding of
      how an interactive DA affects patient-physician communication and SDM, and ultimately CRCS
      adherence.
    

Detailed description: 
      This two-armed randomized controlled trial (300 patients/arm) will compare Colorectal Web
      (CW), the interactive DA, to a non-interactive control website in ten practices in Metro
      Detroit. Patients will be adults aged 50 years and over, not current on CRCS. In the clinic
      before the patient-physician encounter, participants will complete a Patient Baseline Survey.
      They will be randomized to CW or the control website. Data will be collected after the
      patient reviews the respective website (Post-Intervention Survey), during the
      patient-physician encounter (digital audio recording), and after it (Post-Encounter Survey).
      Chart audit will be performed six months after the encounter to determine whether the patient
      underwent CRCS.
    

Intervention name(s): Colorectal Web
Intervention type(s): Behavioral
Intervention description(s): The intervention arm will allow participants on Colorectal Web to manipulate their preferences for CRCS
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Colorectal Cancer; Screening; Prevention
Double-blind and Placebo-controlled Study on Intervention Effect of Medium and Long Chain Fatty Acid Triglyceride on Glycolipid Homeostasis in Patients With Metabolic Syndrome and Mechanisms
Condition: Metabolic Syndrome
MeSH terms: Metabolic Syndrome; Syndrome
Study type: Interventional
Phase: Phase 4

Summary: 
      Double-blind and placebo-controlled study on intervention effect of medium and long chain
      fatty acid triglyceride on glycolipid homeostasis in patients with metabolic syndrome and
      mechanisms
    


Intervention name(s): MLCT supplementation; Control durg
Intervention type(s): Drug; Drug
Intervention description(s): MLCT 25g/d by month for 1 year; Matching placebo 25g/d by month for 1 year
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: metabolic syndrome; MLCT
A Multiple Dose Study of BAY1834845 in Healthy Male Subjects and in Patients With Psoriasis
Condition: Healthy Volunteers; Psoriasis
MeSH terms: Psoriasis
Study type: Interventional
Phase: Phase 1

Summary: 
      To assess safety and tolerability of multiple oral doses of BAY1834845 in healthy male
      subjects (Part 1) and in patients with psoriasis (Part 2).

      To assess the pharmacokinetic (PK) properties of total BAY1834845 in plasma after oral
      multiple doses of BAY1834845 in healthy male subjects (Part 1) and patients with psoriasis
      (Part 2).
    


Intervention name(s): BAY1834845; Matching Placebo; Midazolam
Intervention type(s): Drug; Other; Drug
Intervention description(s): Orally administered.; Orally administered.; Part 1: Orally administered 1mg as a single dose.
Intervention MeSH terms: Midazolam
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Double blind
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Evaluating the Safety of and Immune Response to a Human Parainfluenza Virus Type 3 Ebola Virus Vaccine (HPIV3-EbovZ GP) in Healthy Adults
Condition: Hemorrhagic Fever, Ebola
MeSH terms: Hemorrhagic Fever, Ebola; Hemorrhagic Fevers, Viral; Paramyxoviridae Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the safety, infectivity, and immunogenicity of the
      HPIV3-EbovZ GP Ebola vaccine candidate in healthy adults.
    

Detailed description: 
      The ongoing Ebola virus outbreak in West Africa highlights the need for prevention and
      treatment strategies, as supportive therapy is currently the only treatment for Ebola virus
      disease. The purpose of this study is to evaluate the safety, infectivity, and immunogenicity
      of two doses of the HPIV3-EbovZ GP vaccine candidate administered intranasally in healthy
      adults.

      This study will enroll healthy adults who have low pre-existing serum antibody titers to
      human parainfluenza virus type 3 (HPIV3). Participants will be enrolled sequentially in two
      cohorts. Cohort 1 will receive two doses of 10^6.0 PFU/mL of HPIV3-EbovZ GP, approximately
      4-8 weeks apart. Cohort 2 will receive two doses of 10^7.0 PFU/mL of HPIV3-EbovZ GP,
      approximately 4-8 weeks apart.

      Participants will be admitted to the inpatient unit 1 or 2 days before receiving their first
      dose of the vaccine. While in the inpatient unit, all participants will undergo a medical
      history review, physical examination, nasal wash, blood collection, pregnancy testing (for
      female participants), and pregnancy prevention counseling. Participants will be discharged
      from the inpatient unit on Day 7 or possibly later, depending on the results of participant's
      lab tests. An additional study visit will occur at Day 14.

      On Day 26, participants will be readmitted to the inpatient unit, and they will receive their
      second dose of the vaccine on Day 28. Participants will undergo the same study procedures
      that occurred during the first inpatient stay, and they will be discharged on Day 35.
      Additional study visits will occur on Days 42, 56, 84, 112, 180, 270, and 360.
    

Intervention name(s): HPIV3-EbovZ GP Vaccine
Intervention type(s): Biological
Intervention description(s): Administered intranasally by a VaxINator device
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Ebolavirus
Clinical Trial to Assess the Safety and Efficacy of Intravenous Administration of Allogeneic Adult Mesenchymal Stem Cells of Expanded Adipose Tissue in Patients With Severe Pneumonia Due to COVID-19
Condition: Sars-CoV2
MeSH terms: Pneumonia
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Phase I/II clinical trial to evaluate the safety and efficacy of Allogenic Adipose
      Tissue-Derived Mesenchymal Stem Cells Expanded in patients with severe COVID-19 pneumonia
    


Intervention name(s): ALLOGENEIC AND EXPANDED ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS
Intervention type(s): Drug
Intervention description(s): Two doses of 80 million adipose-tissue derived mesenchymal stem cells
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Perception of Fatigue Among Surgeons During Night Shifts
Condition: Fatigue
MeSH terms: Fatigue
Study type: Observational

Summary: 
      The aim of this study was to illustrate surgeons' own perception of fatigue and the impact
      they felt it had on their performance. This was accomplished through a focus group study,
      where 13 surgeons participated.
    


Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Doctors working at a department of surgical gastroenterology
      
Keywords: focus group study; sleep deprivation; surgery
Allo-HCT MUD for Non-malignant Red Blood Cell (RBC) Disorders: Sickle Cell, Thal, and DBA: Reduced Intensity Conditioning, Co-tx MSCs
Condition: Sickle Cell Disease; Thalassemia; Diamond-Blackfan Anemia
MeSH terms: Anemia, Sickle Cell; Thalassemia; Anemia, Diamond-Blackfan
Study type: Interventional
Phase: Phase 2

Summary: 
      The main purpose of this project is to cure patients with high risk Sickle cell disease and
      other red cell disorders including thalassemia and diamond-blackfan anemia by bone marrow
      transplantation. The patients enrolled in this study will be those who lack matched sibling
      donors and therefore have no other option but to undergo bone marrow transplantation using
      matched but unrelated bone marrow or umbilical cord blood from the national marrow donor
      program registry. Since bone marrow transplantation for these disorders using matched
      unrelated donors has two major problems i.e. engraftment, or , the process of new marrow
      being accepted and allowed to grow in the the patient; and graft-versus-host disease, or the
      process where the new marrow "rejects" the host or the patient, this study has been devised
      with methods to overcome these two problems and thus make transplantation from unrelated
      donors both successful in terms of engraftment and safe in terms of side effects, both acute
      and long term.

      In order to accomplish these two goals, two important things will be done. Firstly, patients
      will get three medicines which are considered reduced intensity because they are not known to
      cause the serious organ damage seen with conventional chemotherapy. These medicines, however,
      do cause intense immune suppression so these can cause increased infections. Secondly, in
      addition to transplantation of bone marrow from unrelated donors, patients will also
      transplanted with mesenchymal stromal cells derived from the bone marrow of their parents.
      Mesenchymal stromal cells are adult stem cells that are normally found in the bone marrow and
      are thought to create the right background for the blood cells to grow. They have been shown
      in many animal and human studies to improve engraftment. In addition, they have a special
      property by which they prevent and are now even considered to treat graft versus host
      disease. Therefore, by using a reduced intensity chemotherapy regimen before transplant and
      transplanting mesenchymal stromal cells, we hope to improve engraftment while at the same
      time decrease the potential for severe side effects associated with a conventional transplant
      which uses extremely high doses of chemotherapy.
    


Intervention name(s): Bone marrow transplantation; Mesenchymal Stromal Cells
Intervention type(s): Procedure; Biological
Intervention description(s): Bone marrow transplantation using matched unrelated donors, reduced intensity conditioning regimen, and co-transplanting mesenchymal stromal cells derived from parental bone marrow.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Randomized Evaluation of Intracoronary Transplantation of Bone Marrow Stem Cells in Myocardial Infarction
Condition: Myocardial Infarction
MeSH terms: Myocardial Infarction; Infarction
Study type: Interventional
Phase: Phase 1

Summary: 
      This research is being done because currently there is no effective way in regenerating or
      replacing the heart muscle that has been damaged after a heart attack.

      The purpose of this study is to test whether injecting cells obtained from the patient's bone
      marrow into the coronary artery can regenerate and replace heart tissue to strengthen heart
      and prevent heart from dilating and developing heart failure.
    

Detailed description: 
      The main objective of this study is to investigate the safety and clinical outcome of
      intracoronary infusion of autologous bone marrow cells in patients with myocardial infarction
      (MI). We hypothesize that patients treated with stem cell therapy will have beneficial
      effects on left ventricular (LV) remodeling and functional regeneration after MI and
      successful primary percutaneous coronary intervention (PCI) in setting of prospective
      randomized controlled trial.

      Congestive heart failure (CHF), which is most commonly caused by acute myocardial infarction
      (AMI), is the most frequent cause of hospitalization in the United States in patients over
      the age of 65. Although current pharmacotherapy can inhibit neurohormonal activation, this
      falls short in preventing LV remodeling and the development of CHF. Stem cells are
      undifferentiated pluripotent cells that can be obtained from the patient and have the
      potential to proliferate and differentiation into cardiomyocytes. The majority of the data on
      stem cell transplantation comes from preclinical animal studies. Although the results are
      interesting and perhaps safe, early phase I clinical studies are small and are very
      preliminary. Data from large, randomized controlled trials are needed to clarify the short
      and long term effects of cellular cardiomyoplasty.
    

Intervention name(s): Intracoronary Transplantation of Bone Marrow Stem Cells
Intervention type(s): Drug
Intervention description(s): Intracoronary application of autologous bone marrow-derived mononuclear cells in infarct artery 3 - 14 days after PCI for acute myocardial infarction.
Other intervention name(s): REVITALIZE
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Myocardial Infarction; Heart Attack; Infarct; Stem Cells; Bone Marrow Derived Mononuclear Cells; CHF; Congestive Heart Failure; Stent; PCI; Percutaneous Coronary Intervention
Impact of Active and Healthy Families
Condition: Overweight; Obesity
MeSH terms: Obesity; Overweight
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the impact of the 10-week Active and Healthy
      Families (AHF) intervention on body mass index (BMI) in Latino youth aged 5-12 years.
    


Intervention name(s): Active and Healthy Families
Intervention type(s): Behavioral
Intervention description(s): Pediatric obesity intervention delivered through five bi-weekly Active and Healthy Families family-based group medical appointments (i.e., sessions).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Primary Health Care; Pediatrics; Obesity; Overweight; Clinical trial; Hispanic Americans; Family; Body mass index
Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging
Condition: Bipolar Disorder
MeSH terms: Bipolar Disorder
Study type: Interventional
Phase: Phase 4

Summary: 
      This study is for subjects with a diagnosis of bipolar disorder who have depression at the
      time of recruitment. It involves brain imaging with an MRI (magnetic resonance imaging) and
      PET scan (positron emission tomography) and treatment with an antidepressant. The medication
      involves adding an SSRI (either celexa/citalopram or prozac/fluoxetine) to a mood stabilizer.
    

Detailed description: 
      Bipolar disorder is associated with alterations of chemicals in the brain, including one
      named serotonin. Treatment of depression in bipolar disorder can be accomplished by
      increasing serotonin function by medications named selective serotonin reuptake inhibitors
      (SSRI's). Serotonin signals in the brain occur through receptors in a way that is similar to
      a lock and key, where serotonin is a key and the receptor is a lock. One important receptor
      is the serotonin 1A (5-HT1A) receptor. This receptor has been found to be abnormal in bipolar
      disorder during periods of depression, as measured by a type of brain imaging called positron
      emission tomography (PET). The amount of brain 5-HT1A receptor measured by imaging has also
      been associated with how well depressed patients with major depressive disorder respond to an
      SSRI medication. This project will measure the 5-HT1A receptors in bipolar depressed
      individuals using PET with the radiotracer [11C]-CUMI-101 and will evaluate the ability of
      this brain imaging signal to predict how patients respond to SSRI treatment when added to a
      mood stabilizer.
    

Intervention name(s): Fluoxetine; Citalopram
Intervention type(s): Drug; Drug
Intervention description(s): Bipolar depressed patients will be treated with fluoxetine in combination with a mood stabilizer (valproate).; Bipolar depressed patients will be treated with citalopram in combination with a mood stabilizer (valproate) if fluoxetine is not clinically warranted.
Other intervention name(s): Prozac; Celexa
Intervention MeSH terms: Fluoxetine; Citalopram
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Comparison of Femoral Tunnel and Clinical Outcome Using Two Anterior Cruciate Ligament Reconstruction Techniques
Condition: Rupture of Anterior Cruciate Ligament
MeSH terms: Rupture
Study type: Interventional

Summary: 
      1. Purpose :To compare of femoral tunnel placement, tunnel geometry and clinical outcome
           using two anterior cruciate ligament reconstruction techniques ; transportal technique
           with flexible reamer and single bundle outside in technique with remnant preservation.

        2. Subjects: anterior cruciate ligament (ACL) injury 66 patients

             -  Double bundle transportal technique with flexible reamer: 33

             -  Single bundle outside in technique with remnant preservation: 33
    

Detailed description: 
      Anterior cruciate ligament (ACL) injury patients : Total 66

        1. Double bundle transportal technique with flexible reamer: 33

             -  Advantage: more normal ACL reconstruction than single bundle technique

             -  Disadvantage: to make the two bone tunnel must remove all the residual tissue.

        2. Single bundle outside in technique with remnant preservation: 33

             -  Advantage: good for being synovium and revascularization. Remained proprioception
                function helps to functional recovery.

             -  Disadvantage: difficult to ensure of visibility and tunnel drilling in the correct
                position because of remnant tissue.
    

Intervention name(s): type of anterior cruciate ligament reconstruction
Intervention type(s): Procedure
Intervention description(s): comparison of different types of anterior cruciate ligament reconstruction. transportal technique is double bundle graft using flexible reamer, outside-in technique is single bundle graft with remnant preservation
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Multiple Ascending Dose Study on Safety, Tolerability, and Pharmacokinetics of AMG 581 in Healthy Subjects or Subjects With Schizophrenia or Schizoaffective
Condition: Schizophrenia or Schizoaffective Disorder
MeSH terms: Schizophrenia; Psychotic Disorders
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to find out the time it takes to absorb, distribute, breakdown
      and remove the drug from the body in healthy participants and subjects with schizophrenia and
      whether it causes any side effects.
    

Detailed description: 
      The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetic
      profile of ascending multiple oral doses of AMG 581 in healthy subjects or subjects with
      schizophrenia or schizoaffective disorder on antipsychotic medication. The study will also
      assess the effects of AMG 581 on midazolam PK in healthy subjects or subjects with
      schizophrenia or schizoaffective disorder on antipsychotic medication.
    

Intervention name(s): AMG 581; Placebo; Midazolam
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Active drug; Placebo; Interaction
Intervention MeSH terms: Midazolam
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Schizophrenia or Schizoaffective Disorder