Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health
Condition: Inflammatory Bowel Diseases; Depressive Episode; Recurrent Depressive Disorder; Anxiety Disorder; Psychological Disorder; Self Harm; Suicide, Attempted; Parasuicide; Eating Disorders; Body Image Disorder; Attention Deficit Hyperactivity Disorder; Behavioral Disorder; Adjustment Disorders; Acute Stress Disorder; Schizophrenia; Bipolar Disorder; Post-traumatic Stress Disorder; Sleep Disturbance
MeSH terms: Intestinal Diseases; Inflammatory Bowel Diseases; Schizophrenia; Depressive Disorder; Stress Disorders, Traumatic; Bipolar Disorder; Attention Deficit Disorder with Hyperactivity; Anxiety Disorders; Suicide; Stress Disorders, Post-Traumatic; Feeding and Eating Disorders; Suicide, Attempted; Adjustment Disorders; Mental Disorders; Stress Disorders, Traumatic, Acute; Body Dysmorphic Disorders
Study type: Observational

Summary: 
      This study is a large population-based analysis in the United Kingdom (UK) using routine
      primary care data to investigate the risk of mental health conditions in children,
      adolescents and young adults with Inflammatory Bowel Disease, compared to those without
      Inflammatory Bowel Disease. The study will also compare the impacts on quality-of-life
      outcomes and use of healthcare services between people with Inflammatory Bowel Disease with
      and without mental health conditions.
    

Detailed description: 
      This study will use routinely electronic medical record (EMR) data from primary care
      practices within the Optimum Patient Care Research Database (OPCRD).

      Stream 1 primary objective is to compare the prevalence and cumulative incidence of mental
      health conditions in children, adolescents and young adults with a diagnosis of Inflammatory
      Bowel Disease, compared to matched population controls without a diagnosis of Inflammatory
      Bowel Disease. The secondary objective is to determine the severity of mental health outcomes
      in those with and without a diagnosis of Inflammatory Bowel Disease.

      Stream 2 primary objective is to determine the impact of mental health conditions in
      children, adolescents and young adults with Inflammatory Bowel Disease on quality-of-life
      indicators, such as records for absence from work or school, unemployment, sleep disturbance
      and substance abuse. The secondary objectives are to compare indicators of Inflammatory Bowel
      Disease severity, such as medication use, surgical intervention, nutritional supplement
      prescriptions and markers of nutritional status including underweight or growth retardation
      in children and adolescents, between those with and without mental health conditions. Then to
      compare healthcare resource utilisation in children, adolescents and young adults with
      Inflammatory Bowel Disease with and without mental health conditions.
    

Intervention name(s): Exposure of mental health condition
Intervention type(s): Other
Intervention description(s): Primary:
Composite of all chronic psychological conditions (depression, anxiety, eating disorders, body image disorders, attention-deficit disorder, behavioural disorders, adjustment disorder, acute stress disorder, and post-traumatic stress disorder).
Major recurrent depression or treated depressive episode. Non-phobia related anxiety episode or disorder.
Secondary:
Self-harm, suicide attempt or suicide related codes, other chronic psychiatric conditions (eating disorders, body image disorders, attention-deficit disorder, behavioural disorders, adjustment disorders, acute stress disorder, schizophrenia, bipolar disorder and post-traumatic stress disorder. Problems with sleep.
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Cases of IBD in childhood and young adults and age, gender and GP matched controls.