Gingival Recession Treatment With Concentrated Growth Factor(CGF)
Condition: Gingival Recession
MeSH terms: Gingival Recession
Study type: Interventional

Summary: 
      Platelet concentrates(PC) are used in the field of periodontology and implantology for the
      content necessary key cells and growth factors to accelerate healing and to provide
      regeneration. Concentrated Growth Factors(CGF) is defined as an innovative method or a new
      generation PC. The purpose of this clinical study was to evaluate the clinical effectiveness
      of Concentrated Growth Factor(CGF) membrane with coronally advanced flap(CAF) procedure's and
      subepithelial connective tissue graft(SCTG) with CAF in the treatment of Miller class I
      gingival recessions (GR).
    

Detailed description: 
      CGF is defined as an innovative method to produce platelet rich fibrin(PRF) or a new
      generation platelet concentrate(PC).The rotational speed of the centrifuge machine used in
      CGF, varies between 2400-3000 rpm. The variability of the rotation speed during
      centrifugation allows a fibrin matrix that larger, more intensive and includes more growth
      factors than PRF. Some studies have been reported that CGF have an inducing effect on
      periodontal ligament stem cells for osteogenic differentiation and clinically provides new
      bone formation for the sinus augmentation. In literature, there is only one clinical research
      associated with multiple gingival recession defects treatment. It showed that CGF with CAF
      surgery increases keratinized gingiva weight and thickness and it maybe prevents
      post-operative relapse for CAF.

      PC has also been mentioned to be effective in to increase the width of keratinized tissue
      with providing root coverage and it may reduce early post-surgical complications, and
      accelerate wound healing in systematic review. In the treatment of isolated or multiple
      gingival recession, PRF and SCTG with CAF procedures have been reported to similar root
      coverage. PRF can be used as an alternative method for SCTG .CGF and PRF have similar
      composition. However higher resistance and viscosity of CGF may protect growth factors from
      proteolysis better than PRF. There is any comparative study for CGF and SCTG in literature in
      terms of clinically or patient related parameters.

      Therefore, the purpose of this clinical study is to evaluate the clinical efficacy of CGF in
      combination with CAF in the treatment of gingival recession's defects, and to compare SCTG in
      combination with CAF. It is also aimed to asses and compare postoperative pain and soft
      tissue healing.
    

Intervention name(s): test groups; control groups
Intervention type(s): Procedure; Procedure
Intervention description(s): Coronally advanced flap procedure is a mucogingival surgery technique that was used to prepare recipient sites. Concentrated growth factor(CGF) membranes were placed over the exposed root surface. The flap was advanced 1 mm coronally from CEJ to completely cover.; Coronally advanced flap procedure is a mucogingival surgery technique that was used to prepare recipient sites. Subepithelial connective tissue graft was placed over the exposed root surface. The flap was advanced 1 mm coronally from CEJ to completely cover.
Other intervention name(s): CGF+ CAF groups; SCTG+CAF
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: growth factor; mucogingival surgery; gingival recession