bioihbjkbjnl/mcl2 huggingface dataset:
Aerobic Exercise to Improve Executive Language Function In Older Adults
Condition: Aging
Study type: Interventional

Summary: 
      The purpose of this study is to see if exercise can improve brain function in older adults
    

Detailed description: 
      Recently, considerable attention has been devoted to examining the beneficial relationship
      between cognition and aerobic exercise in older adults. Specifically, the effects are thought
      to involve higher order cognitive processes, such as working memory, switching between tasks,
      and inhibiting irrelevant information, all of which are thought to be sub- served, in part,
      by the frontal lobes (Colcombe et al., 2006). Importantly, these areas also are most
      susceptible to age-related decline (Raz, 2000) and are essential resources for language
      production (Kemper & Sumner, 2001; Murray & Lenz, 2001). However, despite promising cognitive
      improvement, changes in frontally-mediated executive language functions have been widely
      ignored. This is unfortunate considering impaired word retrieval compromises communicative
      effectiveness, leading to frustration, depression, and withdrawal. Perhaps more importantly,
      communication ineffectiveness, particularly in the elderly, leads to difficulties interacting
      with health care professionals leading to further health care burdens. Since cognition, and
      specifically word retrieval difficulties, usually remain untreated, it is important to find
      treatment strategies for minimizing these deficits. Therefore, the short-term goal and the
      purpose of this proposal is to examine the potential of aerobic exercise to improve executive
      language function in older adults.
    

Intervention name(s): Aerobic group
Intervention type(s): Behavioral
Intervention description(s): 12 weeks of aerobic exercise 3 times a week
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Testosterone MD-Lotion Residual Washing Study
Condition: Hypergonadism
Study type: Interventional
Phase: Phase 1

Summary: 
      The study will evaluate the amount of Testosteron MD-Lotion 2% remaining on the axilla after
      a single dose application in healthy males who undergo a post dose washing procedure.
    


Intervention name(s): Testosterone MD-Lotion
Intervention type(s): Drug
Intervention description(s): Single dose Testosterone MD-Lotion 2%
Intervention MeSH terms: Testosterone
Intervention model: Single Group Assignment
Masking: None (Open Label)
Keywords: Hypergonadism; Testosterone Transfer
Basivertebral Nerve Block During Vertebral Augmentation: An Alternative Approach to Intraprocedural Pain Management
Condition: Vertebral Compression; Vertebra Compression Fracture; Vertebral Fracture
MeSH terms: Fractures, Bone; Spinal Fractures; Fractures, Compression
Study type: Interventional
Phase: Early Phase 1

Summary: 
      The goal of this study is to assess the efficacy of lidocaine basivertebral nerve block as
      intraprocedural anesthesia during vertebral augmentation procedures.
    

Detailed description: 
      Vertebral compression fractures secondary to osteoporosis can be treated with vertebral
      augmentation. Since intraprocedural pain is common during vertebral body endplate
      manipulation, these procedures are often carried out using conscious sedation or general
      anesthesia. Research has shown that the vertebral endplates are innervated by the
      basivertebral nerve, which has been successfully targeted via radiofrequency ablation to
      treat chronic vertebrogenic lower back pain. With this physiology in mind, the investigators
      will attempt to treated participants with vertebral compression using lidocaine-induced
      intraosseous basivertebral nerve block as the primary intraprocedural analgesia.
    

Intervention name(s): Basivertebral nerve block; Lidocaine induced basivertebral nerve block
Intervention type(s): Procedure; Drug
Intervention description(s): Temporary intraosseous basivertebral nerve block using lidocaine; Intraosseous lidocaine basivertebral nerve block
Other intervention name(s): BVN block during vertebral augmentation; Lidocaine BVN block
Intervention MeSH terms: Lidocaine
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Basivertebral nerve block; Vertebral augmentation; BVN block; Kyphoplasty; nerve block; compression fracture
Young With Diabetes Type 1 - Test of an mHealth App
Condition: Diabetes Mellitus, Type 1
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Interventional

Summary: 
      A multicenter randomized controlled trial testing the app "Young with Diabetes"
    

Detailed description: 
      Young people with diabetes type 1, their parents and health care providers have participated
      in developing the mHealth app "Young with Diabetes".

      The aim of the app is to support young people to self-manage their diabetes type 1.

      A test group of 70 young people with diabetes type 1 test the app for 12 months as a
      supplement to standard care and the control group receives standard care only.

      At baseline and after 2, 7 and 12 months HbA1c, problem areas in diabetes, perceived
      competences in diabetes and health care climate are measured.
    

Intervention name(s): Young with Diabetes - app
Intervention type(s): Device
Intervention description(s): The mHealth app "Young with Diabetes" containes 8 main functions:
Contact your health care provider (ask questions, set the agenda for the next clinical visit)
My Department (hotline numbers, videos about the new adult department, pictures of my diabetes team)
Chatroom
Counting Carbohydrates (information and tips about carbs, introduction to apps to count carbs, quiz)
Knowledge-section (Text, links, tips and videos (animations and videoselfies) about What is diabetes?, Alcohol etc.)
Tips packages (Receive a tip about alcohol, drivers license etc.)
To parents (Text, links, tips and videoselfies to parents about what it is like to be young with diabetes and what they can do to support)
Reminder
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Diabetes type 1; Transition; Telemedicine; mHealth app; Youth; Self-management
The Effect of Platelet Rich Plasma on Non-scarring Alopecia
Condition: Androgenetic Alopecia; Alopecia
MeSH terms: Alopecia; Alopecia Areata
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the clinical efficacy of platelet rich plasma (PRP)
      injections for non-scaring alopecia in women. A randomized, placebo-controlled clinical trial
      will be performed where patients with non-scarring alopecia will either receive injections of
      their own PRP or injections of normal saline (placebo). Patients in the treatment group
      (Group A) will have a small amount of their own blood drawn and have their PRP injected into
      their scalp four times. The injections will be given at weeks zero, four, eight, and twenty
      four. The placebo group (Group B) will be given the same schedule but will receive sham
      injections only and will not have any blood drawn. Both groups will have clinical data
      collected at all visits, including a screening visit before enrollment and a final assessment
      visit at week 40, for a total of 6 study visits per patient. Data collection will include
      representative photographs of the scalp and measurements of hair thickness. The results from
      the two groups will then be compared.

      In summary, all study participants will have a screening visit before enrollment, four study
      visits for sub-dermal scalp injections, and one final assessment visit at week 40.
    


Intervention name(s): Platelet Rich Plasma; Normal saline
Intervention type(s): Device; Drug
Intervention description(s): Platelet Rich Plasma (PRP) is defined as an autologous concentration of human platelets that is 3 to 5 times greater than physiologic concentration of platelets in whole blood. Using the Eclipse PRP system, the participants PRP will be attained. The PRP will then be used as described in the arm/group description section.; Preservative-free normal saline will be used as described in arm/group description section.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
The Pilot Study of the Efficacy of Polymyxin-B Hemoperfusion in Critically Ill Patients With Severe Sepsis
Condition: Severe Sepsis
MeSH terms: Sepsis
Study type: Interventional

Summary: 
      This research project is a study to immunology changes in critically ill patients with severe
      sepsis by using Endotoxin Activity Assay (EAA) combined with Polymyxin-B Hemoperfusion.
    


Intervention name(s): Polymyxin-B Hemoperfusion; Standard treatment
Intervention type(s): Procedure; Procedure
Intervention description(s): Endotoxin removal
Intervention MeSH terms: Polymyxins; Polymyxin B
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Treatment
Involvement of the Sodium Pump and Endogenous Digitalis-like Compounds in Bipolar Disorder
Condition: BIPOLAR DISORDER
MeSH terms: Bipolar Disorder
Study type: Observational

Summary: 
      This study deals with the possible molecular mechanisms that underlie the etiology of bipolar
      disorders (BD). Previous studies have implicated Na+, K+-ATPase and endogenous digitalis-like
      compounds (DLC) in the depressive state of this disease. The possibility, however, that they
      are also involved in the manic phase of the disease was never addressed. The results of this
      study may have significant implications for the treatment of BD by DLC derivatives.
    

Detailed description: 
      Depressive symptoms are the hallmark major depressive disorder, dysthymia and bipolar
      depression within the context of bipolar disorder (BD). They share clinical characteristics
      including depressed mood, anhedonia, and low energy and require medical treatment. The Na+,
      K+-ATPase is a major transporter in the plasma membrane which has an important role in
      regulating cell volume, cytoplasmic pH and Ca++ levels. Digitalis-like compounds (DLC);
      steroids identified as normal constituents of human brain, plasma and other tissues,
      exclusively interact with the Na+, K+-ATPase and induce numerous biological effects. We
      raised the hypothesis that Na+, K+-ATPase/DLC system is involved in BD based on studies from
      ours and other laboratories, which tested the involvement of this system in the depressive
      state of BD. The possibility that the interaction of DLC with the Na+, K+-ATPase is involved
      in the manic state of BD was scarcely investigated. To address this issue we intend to
      determine circulating DLC levels in patients with BD at different states of the disease;
    

Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        ALL BIPOLAR PATIENTS IN THE HADASSAH MEDICAL ORGANIZATION PSYCHIATRIC OUTPATIENTS CLINIC
      
Biospecimen description: 
      30 cc of pperipheral blood will be taken every 4 months to determine circulating DLC levels
      in patients
    
Keywords: BIPOLAR; MANIA; DEPRESSION
The Effectiveness of a Nighttime Positioning Hand Splint in Patients With Rheumatoid Arthritis
Condition: Rheumatoid Arthritis.
MeSH terms: Arthritis; Arthritis, Rheumatoid
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of the present study was to evaluate the effectiveness of a nighttime positioning
      hand splint in patients with RA in terms of pain, grip and pinch strength, upper limb
      function, quality of life, and patient satisfaction. The hypothesis is that the stabilization
      of hand during nighttime could decrease pain and consequently improve quality of life.
    

Detailed description: 
      The involvment of wrist and fingers is very common in RA and it could affect hand function
      and, consequently, affect activities of daily living (ADL). Some authors suggest that the
      rest of hand could decrease pain and inflammation. Splints are external appliances that used
      in a specific body part provides the best alignment and rest in correct functional position.
      The goal of a hand, fingers and thumb in RA is stabilize the hand while the patients are not
      making theirs ADL and try to decrease the pain.
    

Intervention name(s): Splint
Intervention type(s): Device
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single
Primary purpose: Treatment
Keywords: Rheumatoid Arthritis; Hand; Splint; Occupational Therapy
Combined Bone Marrow and Kidney Transplant for Multiple Myeloma With Kidney Failure
Condition: Kidney Failure, Chronic; Multiple Myeloma
MeSH terms: Multiple Myeloma; Neoplasms, Plasma Cell; Renal Insufficiency; Kidney Failure, Chronic
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine whether a combined bone marrow and kidney
      transplant will be effective in treating stage II or greater multiple myeloma and associated
      kidney failure. This study will determine whether transplant rejection and the need for
      immunosuppressive drugs are decreased with this combined transplant approach.
    

Detailed description: 
      In very limited human testing, a combined kidney and bone marrow transplant appears to be
      safe and effective in treating multiple myeloma and associated kidney failure. This study
      will evaluate this approach in 10 patients with kidney failure due to or in association with
      stage II or greater multiple myeloma. Treatment prior to transplant will include
      cyclophosphamide, ATGAM (a lymphocyte-specific immunosuppressant), local radiation to the
      thymus, and cyclosporine (an immunosuppressive drug).

      An infusion of donor bone marrow and a kidney graft from a closely matched, related donor
      will be transplanted simultaneously. An additional infusion of donor white blood cells may be
      administered between day 45 and 74 after transplant in an effort to eliminate any remaining
      cancer cells. Patients will remain on cyclosporine for a defined period of time. The
      cyclosporine doses will be slowly decreased and stopped if graft rejection and
      graft-versus-host disease do not occur.

      Each participant will be involved in the study for 3 years; this includes the intervention
      phase (time from initial screening at approximately 7 days before transplant through 100 days
      after the transplant) and continued follow-up visits for at least 2 years following the
      transplant.
    

Intervention name(s): Combined bone marrow and kidney transplant
Intervention type(s): Procedure
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Immune tolerance; Graft vs host disease; Kidney Failure; Kidney diseases; End Stage Renal Disease; Multiple Myeloma; Bone Marrow Transplant; Kidney Transplant; Renal Transplant; Tolerance; Chimerism; ESRD
Efficacy and Safety of Peginterferon a-2a in Patients of Chronic Hepatitis B With Spontaneous Decline of HBV DNA
Condition: Antiviral Treatment of Chronic Hepatitis B
MeSH terms: Hepatitis A; Hepatitis B; Hepatitis B, Chronic; Hepatitis; Hepatitis, Chronic
Study type: Interventional
Phase: Phase 3

Summary: 
      Patients with spontaneous decline of HBV DNA were non-randomly assigned to accept
      peginterferon alfa-2a or entecavir therapy, or didn't accept any antiviral regiment.
    

Detailed description: 
      It was a prospective, non-randomized, open-label study that evaluated the efficacy and safety
      of pegasys treatment in chronic hepatitis B patients with spontaneous HBVDNA decline after
      acute exacerbation.Patients with spontaneous decline of HBV DNA(a decrease of HBV DNA levels
      of more than 2 log(10) IU/mL as compared to baseline before antiviral treatment) after acute
      exacerbation (ALT was 10-30ULN，TBIL was 2-20mg/ml，PTA>60%)were non-randomly divided into 3
      groups: group A, B and C. Before treatment, the patients were counselled on the advantages
      and disadvantages of taking peginterferon or nucleos(t)ide analogue, and the subsequential
      treatment were decided by themselves. Cases in group A receive 180µg of peginterferon alfa-2a
      (Pegasys,Roche) once weekly for 48 weeks. Group B and C were control group, cases in group B
      received an continual entecavir therapy(0.5 mg orally once daily) and those in group C didn't
      accept any antiviral regiment.
    

Intervention name(s): Pegasys(Roche); Entecavir
Intervention type(s): Drug; Drug
Intervention description(s): 180µg of peginterferon alfa-2a (Pegasys,Roche) once weekly for 48 weeks.; continual entecavir therapy(0.5 mg orally once daily)
Other intervention name(s): peginterferon alfa-2a
Intervention MeSH terms: Peginterferon alfa-2a; Entecavir
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Chronic hepatitis B,Spontaneous Decline of HBV DNA,Peginterferon a-2a, entecavir
Influence of Age on Trauma Femoral Fractures
Condition: FEMORAL FRACTURES
MeSH terms: Fractures, Bone; Femoral Fractures
Study type: Observational

Summary: 
      This study aimed to determine the influence of ageing on the incidence and site of femoral
      fractures in trauma patients, by taking the sex, body weight, and trauma mechanisms into
      account.
    

Detailed description: 
      This retrospective study reviewed data from adult trauma patients aged ≥ 20 years who were
      admitted into a Level I trauma center, between January 1, 2009 and December 31, 2016.
      According to the femoral fracture locations, 3859 adult patients with 4011 fracture sites
      were grouped into five subgroups: proximal type A (n = 1,359), proximal type B (n= 1,487),
      proximal type C (n = 59), femoral shaft (n = 640), and distal femur (n = 466) groups. A
      multivariate logistic regression analysis was applied to identify independent effects of the
      univariate predictive variables on the occurrence of fracture at a specific site. The
      propensity score accounts for the risk of a fracture at a specific femoral site was
      calculated and presented visually with age in a two-dimensional plot.
    

Intervention name(s): Proximal type A; Proximal type B; Proximal type C; femoral shaft; distal femur
Intervention type(s): Other; Other; Other; Other; Other
Intervention description(s): Patients with fracture of proximal type A; Patients with fracture of proximal type B; Patients with fracture of proximal type C; Patients with fracture of femoral shaft; Patients with fracture of distal femur
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        This retrospective study reviewed data from 27,462 trauma patients registered between
        January 1, 2009 and December 31, 2016. The inclusion criteria required patients to be aged
        ≥20 years and hospitalized for the treatment of femoral fracture following injury. Patients
        with incomplete data were excluded.
Capabilities of Perinatal Healthcare Institutions in the Federation of Bosnia and Herzegovina
Condition: Prenatal Care
Study type: Observational

Summary: 
      The aim of this study is to assess the level of the perinatal healthcare institution (PHI)
      where the newborns were delivered. We included newborns of both genders that were born in the
      maternity wards in 10 cantons of the Federation of Bosnia and Herzegovina (FBiH). From the
      PHI of the first and second level, 159 newborns were referred to the third level. Out of a
      total of 159 LBWI referred from other PHI, only 19.5% LBWI were transported in less than 4
      hours. In second level PHI, most LBWI died in the first 12 hours after birth.
    


Intervention name(s): Referral to Centre of Higher Organizational Level
Intervention type(s): Other
Intervention description(s): Referral to Centre of Higher Organizational Level. This means referral from a primary neonatal care center to a secondary one, or from the secondary to the tertiary center.
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Newborns that were born in the maternity wards of the Federation of Bosnia and Herzegovina
Comparison of Time Taken for Intubation and Cormack Lehane View Between C-Mac With Glidescope Video Laryngoscopy in Paediatric Patients
Condition: Paediatric Airway
Study type: Interventional

Summary: 
      This study compares the time taken to intubate between Cmac video laryngoscopy with
      Glidescope video laryngoscopy in paediatric patients aged 3-12 years old.
    

Detailed description: 
      This study aims to determine whether are both devices comparable to each other in terms of
      intubation time and Cormack Lehane view in paediatric patients with normal airway undergoing
      elective surgery.
    

Intervention name(s): Glidescope video laryngoscopy/ C-MAC video laryngoscopy
Intervention type(s): Device
Intervention description(s): usage of said devices according to manual
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: GlideScope intubation Vs Cmac intubation
Masking: Single (Participant)
Primary purpose: Device Feasibility
Study of Rufinamide in Pediatric Subjects 1 to Less Than 4 Years of Age With Lennox-Gastaut Syndrome Inadequately Controlled With Other Anti-epileptic Drugs
Condition: Lennox-Gastaut Syndrome
MeSH terms: Lennox Gastaut Syndrome; Syndrome
Study type: Interventional
Phase: Phase 3

Summary: 
      This study was designed to evaluate the cognitive effect, safety, and pharmacokinetics (PK)
      of rufinamide on Lennox-Gastaut Syndrome (LGS) inadequately controlled in pediatric
      participants already taking other anti-epileptic drugs.
    


Intervention name(s): Rufinamide; Any other approved Antiepileptic Drug
Intervention type(s): Drug; Drug
Intervention description(s): Rufinamide up to 45 mg/kg/day, in 2 divided doses, administered as oral suspension (40 mg/mL) as an add-on to the subject's existing regimen of 1-3 antiepileptic drugs (AEDs); Any other approved AED: any other approved AED of the investigator's choice as an add-on to the subject's existing regimen of 1-3 anti-epileptic drugs (AEDs)
Intervention MeSH terms: Rufinamide; Anticonvulsants
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Central Nervous System
Pilot Bioequivalency Study of Exemestane 25 mg Tablet Under Fasted Conditions
Condition: Breast Cancer
Study type: Interventional

Summary: 
      The objective of this study was to prove the bioequivalence of Exemestane 25 mg tablet under
      fasted conditions
    


Intervention name(s): exemestane
Intervention type(s): Drug
Intervention description(s): 25 mg tablet
Other intervention name(s): AROMASIN
Intervention MeSH terms: Exemestane
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment