Treatment of Periodontitis by Conventional 4 Weekly Sections or Within 24 Hours
Condition: Periodontitis
MeSH terms: Periodontitis
Study type: Interventional
Phase: Phase 4

Summary: 
      Periodontitis is a form of gum disease that affects many people in the world. Its traditional
      protocol of treatment includes oral hygiene instruction and dental scaling to remove debris,
      dental plaque and tartar in 4 weekly sections. There is an additional time-reduced option
      also usually cheaper. In this last one, all above described procedures are performed within
      24 hours. However, up to now comparative effectiveness between these both types of treatment
      is not well understood. For, example it is not clear if patients treated in the shorter-time
      experienced more pain. Therefore, the present study used several parameters to clarify
      whether beneficial differences between these therapeutic protocols exist or not. In addition,
      aspects that could help clinicians' and patient's decisions such as experience of pain and
      anxiety related to dental treatment were also investigated. After receiving verbal and
      written explanations and signed the informed consent form 150 individuals (n=15/group) having
      the most common type of periodontitis in adults were randomly allocated to be treated in 4
      weekly sections or within 24 hours. Oral hygiene instructions and dental debridement were
      performed alone or in conjunction with antimicrobial agents: a mouth rinse containing
      chlorhexidine or systemic azithromycin antibiotic tablets. The parameters measured at
      baseline, 3, 6 and 9 months after treatment were: indicators of inflammation, amount of oral
      debris and malodor; quantification of bacteria in plaque samples collected with paper points
      from teeth and tongue; amount of produced saliva and self-reported questionnaires to collect
      information about oral condition, daily activities, pain and anxiety related to dental
      treatment.
    


Intervention name(s): FMS full-mouth scaling; QS quadrant scaling; FMS chlorhexidine rinse; FMS placebo rinse; FMS azithromycin tablets; FMS placebo tablets; QS azithromycin tablets; QS placebo tablets; QS chlorhexidine rinse; QS placebo rinse
Intervention type(s): Procedure; Procedure; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Participants received oral hygiene instructions and full-mouth scaling within 24 hours. Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.; Participants received oral hygiene instructions and quadrant scaling in 4 weekly sections. Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.; Participants received oral hygiene instructions and full-mouth scaling within 24 hours followed by a 60-day use of 0.12% chlorhexidine mouth rinse (15mL/30 seconds/ 2 times a day). Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.; Participants received oral hygiene instructions and full-mouth scaling within 24 hours followed by a 60-day use of placebo mouth rinse (15mL/30 seconds/ 2 times a day). Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.; Participants received oral hygiene instructions and full-mouth scaling within 24 hours followed by a 3-day use of azithromycin tablets (1 tablet/day). Debridement procedures were carried out Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.; Participants received oral hygiene instructions and full-mouth scaling within 24 hours followed by a 3-day use of placebo tablets (1 tablet/day). Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.; Participants received oral hygiene instructions and full-mouth scaling in 4 weekly sections followed by a 3-day use of azithromycin tablets (1 tablet/day). Debridement procedures were carried out Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.; Participants received oral hygiene instructions and full-mouth scaling in 4 weekly sections followed by a 3-day use of placebo tablets (1 tablet/day). Debridement procedures were carried out Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.; Participants received oral hygiene instructions and full-mouth scaling in 4 weekly sections followed by a 60-day use of 0.12% chlorhexidine mouth rinse (15mL/30 seconds/2 times a day). Debridement procedures were carried out Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.; Participants received oral hygiene instructions and full-mouth scaling in 4 weekly sections followed by a 60-day use of 0.12% placebo mouth rinse (15mL/30 seconds/2 times a day). Debridement procedures were carried out Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.
Intervention MeSH terms: Chlorhexidine; Chlorhexidine gluconate; Azithromycin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment