bioihbjkbjnl/mcl2 huggingface dataset:
A Comparison of Meperidine for Post-Cesarean Analgesia: Bolus Versus Infusion and Bolus
Condition: Cesarean Section
Study type: Interventional

Summary: 
      The purpose of this study is to determine if epidural meperidine administered by
      patient-controlled bolus button is equivalent to a low dose infusion plus patient-controlled
      bolus.
    

Detailed description: 
      The objective of this study is to compare the efficacy, patient satisfaction, and incidence
      of side effects of meperidine patient-controlled epidural analgesia (PCEA) with and without a
      basal infusion for post-cesarean section analgesia.
    

Intervention name(s): Meperidine
Intervention type(s): Drug
Other intervention name(s): Demerol
Intervention MeSH terms: Meperidine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: analgesia; meperidine; epidural
Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD
Condition: Treatment Resistant Major Depressive Disorder
MeSH terms: Depressive Disorder; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 4

Summary: 
      This is a multi-site, randomized, open-label, effectiveness trial comparing three treatment
      arms for Major Depressive Disorder (MDD) patients with TRD who are currently on ongoing,
      stable and adequate antidepressant therapy (ADT). Adequate ADT is defined as a
      therapeutically sufficient dose for a sufficient treatment period, which would be expected to
      be effective as listed in the MGH Antidepressant Treatment Response Questionnaire (ATRQ).
      Patients will be randomized in a 1:1:1 fashion to one of three open-label treatment arms: a)
      aripiprazole augmentation, b) rTMS augmentation, and c) switching to venlafaxine XR or
      Duloxetine.
    


Intervention name(s): Aripiprazole; Repetitive transcranial magnetic stimulation (rTMS); Venlafaxine XR
Intervention type(s): Drug; Device; Drug
Intervention description(s): Oral adjunctive therapy with aripiprazole, dose adjusted for effectiveness and tolerability.; Adjunctive therapy with transcranial magnetic stimulation, dose adjusted for effectiveness and tolerability.; Oral switch therapy with venlafaxine, dose adjusted for effectiveness and tolerability.
Other intervention name(s): Abilify; Effexor XR
Intervention MeSH terms: Aripiprazole; Venlafaxine Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Effects of Immersive Virtual Reality on Balance, Mobility, and Fatigue in Patients With Multiple Sclerosis
Condition: Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Sclerosis; Fatigue
Study type: Interventional

Summary: 
      Gait disorder, imbalance, and fatigue are the most frequently reported complaints in Multiple
      Sclerosis (MS), a chronic neurodegenerative disease. The first symptoms in patients with MS
      are emerging in the age range 20-50 and these patients need long-term rehabilitation. The
      virtual reality applications developed for these problems which affect the quality of life
      negatively and cause disability in the following periods may be a good alternative for
      conventional rehabilitation applications. In this long-term where motivation is important,
      virtual reality applications in different environments provide patients with the opportunity
      to do many different tasks amused. In recent years, the vividness has been increased by the
      3D virtual reality headsets.

      The aim of this study is to investigate the effects of immersive virtual reality on the
      balance, mobility, and fatigue in patients with MS.
    

Detailed description: 
      The study was designed as a prospective, randomized controlled study. The patients will be
      randomly assigned to three groups, the "immersive virtual reality (IVR)" group, the "dynamic
      balance training (DBT)" group and the control group. The trainings will be twice a week for 8
      weeks. In the IVR group, firstly 30 minutes of Pilates training, 10 minutes of rest and then
      20 minutes of virtual reality will be applied. In the DBT group, 20 minutes of dynamic
      balance exercises will be applied after Pilates training. In dynamic balance training,
      exercises will consist of similar movements required by virtual reality games. The control
      group will be taught relaxation exercises and will be asked to perform the exercises 2 times
      for 8 weeks at home.

      Statistical analyses will be performed using the SPSS software version 15 (SPSS Inc. Chicago,
      IL, USA). The pre-training and post-training measurements of groups will be compared with the
      Wilcoxon Test. The significance level was set at p< 0.05.
    

Intervention name(s): Virtual reality group; Dynamic Balance Training
Intervention type(s): Other; Other
Intervention description(s): Immersive virtual reality training protocol consisted of "Football" and "Guillotine" games.; Dynamic balance training protocol consisted of holding the ball and running away from the ball with a physiotherapist.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: prospective randomize controlled study
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Multiple Sclerosis; virtual reality; balance; mobility; fatigue
Case Series of New Alloplastic Bone Graft Material
Condition: Periodontology; Oral Surgery
Study type: Interventional

Summary: 
      A case series to compare the handling and effectiveness of two different treatment approaches
      using a new alloplastic bone graft material in ridge preservation compared to allograft
      existing historical data.
    


Intervention name(s): easy-graft (beta-Tricalcium Phosphate)
Intervention type(s): Device
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Phase 3 Study of A Group A, C Polysaccharide Meningococcal and Type b Haemophilus Influenzal Conjugate Vaccine
Condition: Meningitis; Influenza
MeSH terms: Meningitis
Study type: Interventional
Phase: Phase 3

Summary: 
      Haemophilus influenzae is an important pathogen which can cause primary infection and
      respiratory viral infection in infants and leaded to secondary infections. The infection of
      haemophilus is a major cause of morbidity and mortality in infants and children. At present,
      the developed conjugant Hib vaccine is proved to be safe and effective. Because Hib vaccine
      can prevent meningitis, pneumonia, epiglottis inflammation and other serious infection caused
      by Hib bacteria, the WHO suggested that Hib vaccine should be included in the infant's normal
      immune programming.

      Since the use of meningitis aureus polysaccharide vaccine, incidence of a disease in recent
      years is declined and maintain to the level of 0.5 per 1/100 thousand. But meningitis aureus
      polysaccharide vaccine with a relatively poor immune response in the infants under the age of
      two, and the remaining 60% with a low antibody level and a short duration.

      The immunogenicity and safety of this vaccine has been proved in older children aged 6-23
      months and 2-5 years. And in the phase I study which was conducted in February, 2012, the
      safety profile of this vaccine is proved to be acceptable in infants aged 3-5 months. The
      phase III study is aimed to further evaluate the safety and the immunization of the vaccine.
      The objective of this study is to evaluate the safety of the group A, C polysaccharide
      meningococcal and type b haemophilus influenzal conjugate vaccine.
    


Intervention name(s): A+C+hib Conjugate Vaccine; Placebo; A+C Vaccine; Hib vaccine
Intervention type(s): Biological; Biological; Biological; Biological
Intervention description(s): The group A, C polysaccharide meningococcal and type b haemophilus influenzal conjugate vaccine (Wuxi Royal Biological Co., LTD, 20110101) will be administered on one arm, intramuscularly, per 0.5ml dose; Placebo will be administered intramuscularly on the other arm, intramuscularly, per 0.5ml dose; The group A, C polysaccharide meningococcal vaccine (Yunnan Walvax Biotechnology Co., LTD, 20101202) will be administered intramuscularly on one arm, per 0.5ml dose; The type b haemophilus influenzal vaccine (Sanofi Pasteur Limited) will be administered intramuscularly on the other arm, per 0.5ml dose
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Prevention
Keywords: immunogenicity; safety; group A, C polysaccharide meningitis; type b haemophilus Influenza
Islatravir and Methadone Pharmacokinetics (MK-8591-029)
Condition: HIV-1 Infection
Study type: Interventional
Phase: Phase 1

Summary: 
      The present study is designed to determine the effect of islatravir (ISL) [MK-8591] on
      methadone pharmacokinetics (PK). The primary objective is to assess whether ISL impacts the
      area under the plasma concentration time curve from dosing to 24 hours postdose (AUC0-24) of
      S-methadone and R-methadone in participants on oral methadone therapy. It is hypothesized
      that the plasma AUC0-24hr for S- and R-methadone will be similar after methadone alone
      compared to methadone and ISL 60 mg coadministration.
    


Intervention name(s): Islatravir
Intervention type(s): Drug
Intervention description(s): ISL 30 mg x 2 (60 mg total) capsules taken by mouth.
Other intervention name(s): MK-8591
Intervention MeSH terms: Islatravir
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Optimizing Pain and Rehabilitation After Knee Arthroplasty
Condition: Total Knee Arthroplasty
Study type: Interventional
Phase: Phase 3

Summary: 
      The aim of this study is to determine the best method of pain control that will help with
      rehabilitation after total knee arthroplasty (TKA). Currently, the best method for pain
      control after TKA appears to be continuous femoral nerve block (FNB) where a small tube is
      placed beside the nerve that provides sensation to a large part of the knee and local
      anesthetic infused after surgery causing numbness to the surgical site. A single injection
      method also exists and may provide similar benefits. Both methods require training and can
      result in side effects such as temporary weakness (while the local anesthetic is still
      working) that can inhibit rehabilitation. A newer method injecting local anesthetic into the
      joint after surgery (Local Infiltration Analgesia (LIA)) is becoming common, does not cause
      weakness and can be done quickly at the end of surgery. It is unknown if the pain control
      provided by LIA is as good as that of FNB. This study will compare the femoral nerve block,
      continuous femoral nerve block and LIA technique to determine which provides better pain
      relief after TKA.
    

Detailed description: 
      This will be a prospective, randomized, double blind study. Patients will be randomized using
      a computer-generated sequence to one of three groups:

      Group 1: Continuous femoral nerve block group (cFNB) Group 2: Single injection femoral nerve
      block group (sFNB) Group 3: Local infiltration analgesia group (LIA)

      Inclusion criteria: Patients between the ages of 18 and 85 having primary tri-compartmental
      total knee arthroplasty.

      Exclusion criteria: Allergy, intolerance, or contraindication to any study medication (see
      below), inability to walk independently prior to TKA, inability to comprehend French or
      English, use of major tranquilizers, ASA 4 or 5, BMI > 40, opioid tolerance (opioid
      consumption > 30mg oral morphine or equivalent per day), pregnancy
    

Intervention name(s): continuous FNB; single femoral nerve block; local infiltration analgesia
Intervention type(s): Other; Other; Other
Intervention description(s): femoral nerve block (ropivacaine 0.5%, 20 mL) with femoral nerve block infusion 48 h (ropivacaine 0.2%, 5mL/h), placebo local infiltration; single femoral nerve block (ropivacaine 0.5%, 20 mL), placebo femoral nerve block infusion, placebo local infiltration; placebo fascia iliac block, placebo fascia iliaca infusion, local infiltration analgesia (tricompartmental injection of 150 mL ropivacaine 0.2%, ketorolac 30 mg, epinephrine 10 microg/mL)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
The Efficacy of LPPRP in the Treatment of Chondromalacia Patella
Condition: Chondromalacia Patellae
MeSH terms: Cartilage Diseases; Chondromalacia Patellae
Study type: Interventional

Summary: 
      Chondromalacia patella(CP) is a common cause of anterior knee pain in the population under 50
      years of age. CP is characterized by softening or varying degrees of damage to the patellar
      cartilage. The positive effects of leukocyte poor-platelet rich plasma (leukocyte
      poor-platelet rich plasma, LP-PRP) on cartilage repair and degenerative findings are known.
      However, there is no randomized controlled study on this subject in CP. The aim of this study
      is to investigate the effect of LP-PRP on pain, function, walking distance and magnetic
      resonance imaging (MRI) findings in CP patients.The study is the first to investigate the
      effect of LP-PRP on cartilage measurement with MRI in Chondromalasia Patella. Patients with
      anterior knee pain who applied to the physical therapy and rehabilitation outpatient clinic
      of Kayseri City Hospital, patients with Chondromalacia patella in MRI will be included in the
      study. A total of 40 patients will be randomized into 2 groups. The exercise program will be
      applied to both groups as a home program for 4 weeks.
    

Detailed description: 
      A randomized, prospective, controlled study included 28 patients with MRI stage 2 and above
      Chondromalasia Patella findings. The patients were randomized into 2 groups, group 1 (the
      group in which 2 doses of suprapatellar bursa were injected with 2 doses of 3 cc LP-PRP at
      1-week intervals and a 4-week home exercise program was given) and group 2 (the control
      group, the group given a 4-week home exercise program). Patients were tested on the Visual
      Analogue Scale (VAS) day, night and motion, Western Ontario McMaster Universities
      Osteoarthritis Index (WOMAC), 6-minute walk test (6MWT) at baseline,1st week, 4th week and
      12th week and cartilage thickness, including defective cartilage thickness, and
      Chondromalasia Patella Outerbridge Staging were evaluated on MRI at baseline and 12th week.
      WOMAC value was taken as the primary outcome measure and MRI cartilage values were taken as
      the secondary outcome measure.

      Clinic Responsible for Research: Physical Therapy and Rehabilitation Clinic of Kayseri City
      Hospital
    

Intervention name(s): Exercise; LP-PRP
Intervention type(s): Behavioral; Biological
Intervention description(s): quadriceps isometric exercises, straight leg raises, semi-squat exercises, hip flexors, hamstring and iliotibial band stretching exercises, strengthening exercises for hip abductors and adductors; The LP-PRPs to be applied will be obtained by centrifugation of the venous blood taken from the patients by manual methods.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: RANDOMIZED CONTROLLED
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Chondromalacia Patellae; leukocyte-poor platelet-rich plasma; magnetic resonance imaging
Cytokine Regulation of Periradicular Pain in Humans
Condition: Chronic Apical Periodontitis of Pulpal Origin
MeSH terms: Periodontitis; Periapical Periodontitis
Study type: Observational

Summary: 
      This clinical trial evaluates the role of cytokines in patients needing root canal treatment
      with diagnosis of necrotic pulp and chronic apical periodontitis
    

Detailed description: 
      This study evaluates whether periradicular exudate concentrations of cytokines differ in
      patients experiencing pain and mechanical allodynia due to pulpal necrosis with an acute
      exacerbation of a chronic apical periodontitis, as compared to patients with pulpal necrosis
      with chronic apical periodontitis, but no pain or mechanical allodynia
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients presenting to the Endodontics department with an indication for root canal
        treatment
      
Biospecimen description: 
      Sterile paper points are placed in the canal for 30 seconds
    
Keywords: pain
Iron Bioavailability From Dairy Product
Condition: Healthy Volunteers
Study type: Interventional

Summary: 
      Determination of fractional iron absorption from dairy product fortified with 2 labelled iron
      compounds
    

Detailed description: 
      This single center trial will be double-blind, controlled randomized with a crossover trial.
      One group (n=10) will start the study with the consumption of a Fe-54 salt fortified dairy
      product, while the other group will start the study with the consumption of Fe-57 salt
      fortified dairy product. The day after, in a cross over design, subjects will be administered
      the alternative test product. A blood sampling will be performed 14 days after the last
      stable isotope administration to allow the measurement of Fe stable isotope ratios and the
      calculation of Fe absorption. The duration of the trial will be 16 days in total.

      The total sample size is 20 enrolled subjects. Patients will be healthy females aged 18-40
      years old
    

Intervention name(s): Dairy product fortified with enriched Fe-54 salt (1); Dairy product fortified with enriched Fe-57 salt (2)
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 2.5mg of Fe per 100g of product; 2.5mg of Fe per 100g of product
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Pharmacokinetics and Safety of RV521 Formulations
Condition: Respiratory Syncytial Virus Infections
MeSH terms: Respiratory Syncytial Virus Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      The main aims of the study are to assess the pharmacokinetics and safety of single doses of
      RV521 administered as two different formulations
    


Intervention name(s): RV521
Intervention type(s): Drug
Intervention description(s): Single doses of RV521 administered as the drug in capsule formulation when fed and as the dry powder blend formulation dispersed in water when fed and whilst fasting, each on a separate dosing day.
Other intervention name(s): Sisunatovir
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Autofluorescence Detection of Oral Malignancies and Database and Biospecimen Collection to Identify Biomarkers of Head and Neck Tumor Progression
Condition: Oral Cancer
MeSH terms: Mouth Neoplasms; Head and Neck Neoplasms
Study type: Observational

Summary: 
      This research may help dentists or surgeons to better detect areas in the mouth that are
      either prone to cancer or are early cancers. The earlier the detection on cancer in the
      mouth, the better the chance that treatment or prevention can be more effective.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Dental clinic patients
      
Biospecimen description: 
      saliva, oral mucosal and tongue brushings.
ReliefLink: A Preventative Mobile Toolkit for Follow-Up Care of Psychiatric Patients
Condition: Suicide, Suicidal Ideation
MeSH terms: Suicide; Suicidal Ideation
Study type: Interventional

Summary: 
      The purpose of this study is to increase use and availability, as well as assess the
      feasibility of the ReliefLink (RL) application for use in conjunction with standard care to
      promote psychological health and prevent suicidal behavior.
    

Detailed description: 
      The aims of this study of ReliefLink application are to determine the utility of ReliefLink
      self-reports of suicidal ideation, negative emotions, loneliness, subjective well-being,
      flourishing, mental toughness, positive emotions, learned optimism, resilience, and
      post-traumatic growth. Additional aims are to evaluate the impact of ReliefLink on perceived
      access to/usage of care and resources and to explore participant acceptance of ReliefLink as
      a technological support for standard treatment through human systems engineering of treatment
      plan adherence and user interview.
    

Intervention name(s): Relief Link Application Daily Tasks
Intervention type(s): Behavioral
Intervention description(s): Participants will complete daily mood tracking and completion of a minimum of one stress management activity per day. Relaxation exercises to choose from on the current version of RL are audio files (i.e., no visuals), and consist of: Guided Meditation, Energizing Breath, Guided Visualization for Relaxation, Progressive Relaxation, Mindfulness Meditation Body Scan, and Mindfulness of Breathing.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Suicidal behavior, Mobile Application, Mobile Health Tool
Evaluation of Objective Perimetry Using Pupillometer
Condition: Retinitis Pigmentosa; Glaucoma; Visual Field
MeSH terms: Glaucoma; Retinitis; Retinitis Pigmentosa
Study type: Observational

Summary: 
      Objective perimetry can better monitor visual field defects in RP and Glaucoma patients than
      conventional subjective perimetry.The PLR ( Pupil Light Reflex ) of the short and long wave
      ratio should be significantly higher in areas of visual field defects in RP and Glaucoma
      patients.
    

Detailed description: 
      Pupil light reflex will be measured by a pupillometer in response to short and long
      wavelength light small spot stimulus in different area of the visual field. The PRL will be
      measured in four quadrant, central, 10, 20, and 30 degree from the visual axis.

      Stimulus duration will be 1000 ms (1 sec), with intervals of 890 ms between stimuli. The
      stimuli size V with light intensity of 39.8 cd-s/m2 for both short wavelength stimuli (peak
      485 nm) and long wavelength stimuli (peak 620nm).
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        primary care clinic
      
Keywords: Pupillometer; Retinitis Pigmentosa; Glaucoma; Objective perimetry