bioihbjkbjnl/mcl2 huggingface dataset:
Outcomes of Sleeve Gastrectomy in Obese Patients, Retrospective Study.
Condition: Morbid Obesity
MeSH terms: Obesity, Morbid
Study type: Observational

Summary: 
      This study will be a retrospective study in which we will review patients who underwent
      laparoscopic sleeve gastrectomy at Sohag University Hospital in the period from january 2017
      to May 2018.Assessment of outcomes as Effects on weight, Effects on co-morbidities and Post
      operative complications.
    


Intervention name(s): sleeve gastrectomy
Intervention type(s): Procedure
Intervention description(s): Laparoscopic sleeve gastrectomy gives long-standing improvement or resolution of obesity-related conditions and also survival benefit. It is highly cost-effective. Surgical procedures for the treatment of obesity.
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        both males and females, age from 18 to 65 yrs complain of obesity with body mass index ≥ 40
        kg/m2 or body mass index ≥ 35 kg/m2 with comorbidities diseases.
      
Keywords: morbid obesity; sleeve gastrectomy; bariatric surgery; weight loss
Single-cell CBD Biomarkers of Inflammation Reduction in People Living With HIV
Condition: Chronic Inflammation
MeSH terms: Inflammation
Study type: Interventional
Phase: Phase 4

Summary: 
      People living with HIV (PLWH) are affected by comorbidities appearing to be strongly related
      to chronic inflammation, a condition characterizing PLWH.

      The investigators propose to study the effects of CBD on inflammation in PLWH, and establish
      the molecular role of different immune cells in this process. The investigators plan to use
      single cell RNA-sequencing (scRNAseq) to isolate CBD-specific cellular phenotypes from five
      persons with HIV who will provide blood samples before and after taking CBD.
    


Intervention name(s): CBD oil
Intervention type(s): Drug
Intervention description(s): Each participant will be provided two 30mL(Milliliters) bottles (2000mg CBD per bottle) with a syringe dropper during their initial (baseline) visit with instructions to administer the solution under the tongue (0.5 cc ~1/2 dropper) twice per day (BID) 8-12 hours apart (morning and evening) at the prescribed daily dosage (63mg/day).
The investigators plan to collect samples from five patients over three time points: baseline (no CBD), and after one and two months of CBD-administration
Other intervention name(s): Cannabidiol
Intervention MeSH terms: Cannabidiol
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Clinic to Home Robotics-assisted Telerehabilitation for Upper Limb (CHISEL)
Condition: Stroke
MeSH terms: Stroke
Study type: Observational

Summary: 
      Hemiparetic weakness is common after stroke and only a small group of patients achieve useful
      upper limb function despite best rehabilitation efforts. This is due to the lack of intensive
      upper limb therapies to drive neuroplasticity either in clinic or at home.

      In this study, we plan to pilot home-based, robot-aided-therapy using H-man to deliver
      intensive arm rehabilitation.
    

Detailed description: 
      It has been assumed that stroke survivors reach a plateau in their recovery within 3-6 months
      of their stroke. They tend to receive minimal rehabilitation support once they are discharged
      to the community citing obstacles such as ambulation, transportation, and cost.

      H-man is a novel telerehabilitation, upper limb training robot, that will deliver robot-aided
      therapy in patients' homes by clinic-based therapists through remote monitoring and under the
      supervision of their caregivers.

      The study aims to refine and evaluate the feasibility, efficacy and safety of home-based
      training using the H-man robot.
    

Intervention name(s): H-Man
Intervention type(s): Device
Intervention description(s): H-Man device will be deployed to patients for onboarding and home-based training.
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients in outpatient clinics
Comparison of Foley Balloon With or Without Traction for the Cervical Ripening
Condition: Pregnancy
Study type: Interventional
Phase: Phase 3

Summary: 
      We will compare the use of foley bulb catheters placed in the cervix for ripening of the
      cervix for labor induction,.
    

Detailed description: 
      One arm will have the foley balloon placed alone in the cervix. And one arm will have the
      foley balloon placed in the cervix and then attached to a weight (1000 cc Iv Bag of fluid).
      Our hypothesis is that the weighted balloon will be more effective than the non-weighted
      balloon in the ripening of the cervix for induction of labor
    

Intervention name(s): foley balloon only; foley balloon with weight attached
Intervention type(s): Device; Device
Intervention description(s): place foley balloon only in cervix; foley balloon with 1000cc IV bag attached
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: pregnancy; induction of Labor; Cervical ripening; Foley balloon
Cognitive Bias Modification (CBM) Via Imagery and Internet Cognitive Behavioural Therapy (iCBT) for Depression
Condition: Depression
MeSH terms: Depression; Depressive Disorder
Study type: Interventional

Summary: 
      A randomised controlled trial comparing Internet based cognitive behavioural therapy for
      major depressive disorder plus a cognitive bias modification intervention (OxIGen) version A
      vs. Internet based cognitive behavioural therapy for major depressive disorder plus a
      cognitive bias modification intervention (OxIGen) version B on symptoms of depression and
      negative interpretation bias.
    

Detailed description: 
      Cognitive accounts of depression and anxiety emphasize the importance of cognitive biases in
      the maintenance of disorders. One specific bias is the interpretation of ambiguous
      information. A negative interpretation bias is defined as a systematic tendency to interpret
      potentially ambiguous information in a negative rather than benign way and this bias has been
      associated with symptoms of depression. Research has led to the recent development of
      computerized cognitive bias modification (CBM) techniques to augment such biases and it has
      been suggested that CBM techniques may be useful as an adjunct to current treatments to
      enhance maintenance of treatment gains and minimize relapse rates. The fact that CBM
      procedures lend themselves to being delivered remotely, are cost-effective, and can be
      self-paced in ways that suit the patient make them an ideal candidate for inclusion in the
      Internet-based cognitive behavioural therapy (iCBT) programs currently offered through St.
      Vincent's Hospital and the University of New South Wales. Therefore, the primary aim of the
      current trial is to evaluate the acceptability and effectiveness of adding CBM procedures to
      the existing iCBT modules offered through St. Vincent's Hospital and the University of New
      South Wales. It is expected that iCBT + CBM (active version) will result in superior
      treatment outcomes as indexed by a standardized clinical battery compared to iCBT + CBM
      (control version).
    

Intervention name(s): CBM; iCBT
Intervention type(s): Other; Other
Intervention description(s): CBM is an Internet-based intervention comprised of delivery of auditory scenarios taking place over 1 week.; iCBT is a validated online CBT treatment program for depression delivered in 6 lessons over 10 weeks.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Probiotic Supplementation in Children With ADHD
Condition: ADHD
MeSH terms: Attention Deficit Disorder with Hyperactivity
Study type: Interventional

Summary: 
      This randomised, placebo controlled trial explores the effects of supplementation with a
      probiotic drink (kefir) in children diagnosed with ADHD on behaviour, sleep, attention and
      the gut microbiome.
    

Detailed description: 
      Children with Attention Deficit Hyperactivity Disorder (ADHD) can suffer debilitating
      symptoms, including problematic behaviour and sleep. Dietary manipulations may be a helpful
      treatment option for children, but the most effective are highly restrictive, with little
      known about why they might work.

      Optimising gut bacteria may help alleviate some of the symptoms of this condition via the
      gut-brain-axis. The consumption of a probiotic fermented drink (kefir) can positively
      influence composition of gut bacteria.

      The purpose of this study is to explore the effects of supplementation of a probiotic drink
      (kefir) on behaviour, sleep, attention and the gut microbiome in children diagnosed with
      ADHD.

      In a six-week randomised controlled double-blind, placebo controlled trial, 70 children
      diagnosed with ADHD (aged 8-13 years) will be randomised to be given either a probiotic drink
      (kefir) or a placebo drink. At the beginning and the end of the study a combination of
      questionnaires, cognitive assessment, sleep/physical activity measures and microbiome
      analysis will be employed to assess the effect of kefir consumption on symptoms of ADHD and
      the gut microbiome.
    

Intervention name(s): Experimental: Kefir probiotic drink (supplied by Nourish); Placebo comparator
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 125ml per day of dairy based probiotic drink (Kefir) containing ≥ 50billion colony forming units (CFU), supplied in plain packaging.; 125ml of non-fermented dairy based placebo (UHT milk) per day, supplied in plain packaging.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomised double-blind quantitative repeated measures design
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: microbiome; ADHD; probiotic; Kefir
The Efficacy of S-adenosyl Methionine (SAMe) Versus Pentoxiphylline in Patients With Non-alcoholic Steatohepatitis With Fibrosis
Condition: Non-alcoholic Steatohepatitis
MeSH terms: Fatty Liver; Non-alcoholic Fatty Liver Disease
Study type: Interventional

Summary: 
      Nonalcoholic fatty liver disease is one the most commonly encountered conditions in a daily
      outpatient Hepatology clinic. Secondly our country is the diabetic capital of the world and
      so the incidence of NAFLD (Non Alcoholic Fatty Liver Disease) is expected to rise in the
      future. It is a spectrum of hepatic pathology, ranging from simple steatosis,
      steatohepatitis, to cirrhosis. Nonalcoholic steatohepatitis (NASH) is a more advanced form of
      disease where steatosis is accompanied by hepatocyte injury as well as infiltration of
      inflammatory cells. Approximately 10-20% of patients with NASH may progress to cirrhosis.
      NASH is felt to be a major etiology of cryptogenic cirrhosis. Around 6230 human studies out
      of which 49 RCTs have been done till date to define the appropriate treatment of nonalcoholic
      steatohepatitis. However, still a controversy and no recommended treatment available till
      date. Recently published PIVENS trial has shown that Vitamin E has proven benefit in NASH.
      Other trials have also shown that pentoxiphylline has shown benefit in the form of
      histological improvement and biochemical improvement in the form of liver enzymes. Role of
      SAMe has been studied in alcoholic liver disease and showed to improve in both biochemical
      and histological features. However the usefulness of SAMe in NAFLD is not known till now.
      Hence this study has been designed.
    


Intervention name(s): S-adenosylmethionine (SAMe); pentoxiphylline (PTX)
Intervention type(s): Drug; Drug
Intervention MeSH terms: Pentoxifylline
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effects of Omega 3 in Hemodialysis Patients
Condition: Hemodialysis; End Stage Renal Disease
MeSH terms: Kidney Diseases; Kidney Failure, Chronic
Study type: Interventional

Summary: 
      The aim of the study was to determine the effects of a 3-week fish oil oral supplementation
      on the metabolic fate and thermogenic effect of an oral glucose load in hemodialysis
      patients.
    


Intervention name(s): fish oil supplementation
Intervention type(s): Behavioral
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Screening
Keywords: nutrition; omega 3 fatty acids; insulin resistance
Pneumocystis Jerovici Pneumonia in Infants and Steroids
Condition: Pneumonia, Pneumocystis Jerovici
MeSH terms: Pneumonia; Pneumonia, Pneumocystis
Study type: Interventional

Summary: 
      This is a double-blind randomized controlled trial assessing the efficacy of adjuvant
      corticosteroids in clinically diagnosed Pneumocystis jiroveci pneumonia in infants.
    

Detailed description: 
      The study aims to determine whether the early administration of adjuvant corticosteroids in
      addition to high dose oral Co-trimoxazole reduces mortality amongst infants aged 2-6 months
      with vertically acquired HIV and clinically diagnosed Pneumocystis jiroveci pneumonia.
      Infants will be randomized to receive either a steroid regime of oral prednisolone at 2 mg/kg
      for 7 days, then 1 mg/kg for 7 days, then 0.5mg/kg for 7 days for a total of 21 days or
      placebo.
    

Intervention name(s): Prednisone; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): The steroid regime will be oral prednisone at 2 mg/kg for 7 days, then 1 mg/kg for 7 days, then 0.5mg/kg for 7 days for a total of 21 days.
Intervention MeSH terms: Prednisone
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Pneumocystis Jiroveci; Steroids; Infants
Effects of Donepezil on Deficits Associated With Age-Related Decrease of Growth Hormone
Condition: Elderly
Study type: Interventional

Summary: 
      The planned study has two purposes:

        1. It is to provide evidence that the administration of a cholinesterase inhibitor will
           result in an increase of IGF-I (primary variable) and in an increase of the secretion
           growth hormone (secondary variable) that can be maintained throughout the
           treatment-period of one year.

        2. The study also tests the hypothesis that maintenance of increased blood levels of growth
           hormone and IGF-I can stop or delay the age-related changes of body composition
           (secondary variables) .
    


Intervention name(s): Donepezil
Intervention type(s): Drug
Intervention description(s): week1 - week12: 1 tablet per day (5mg) week13 - week52: 1 tablet per day (10mg)
Intervention MeSH terms: Donepezil
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Aging
Impact of Probiotics on Weight Control and Body Composition in Overweight and Obese Individuals
Condition: Obesity
MeSH terms: Overweight
Study type: Interventional

Summary: 
      The aim of the study is to evaluate the potential of probiotics on weight management. It is
      hypothesized that the consumption of 1 capsule of probiotics daily will modulate the
      intestinal gut microbiota thereby reducing body weight and fat compared to those who do not
      consume probiotics. In addition, a diet supplemented with probiotics can be expected to be
      more beneficial than a diet without probiotic supplementation in impacting biomarkers of
      obesity-associated disorders including diabetes, hypertension and cardiovascular disease
      (CVD).
    

Detailed description: 
      Overweight, obese men and women volunteers aged between 18-65 yrs with BMI greater than or
      equal to 25 will be recruited from the Winnipeg (Manitoba, Canada) area to participate in a
      two arm crossover, randomized, double-blind, placebo-controlled, free-living intervention
      study for 60 days per study period following obtainment of informed consent. Participants
      will be informed to maintain their usual diets as well as their physical activity level.

      After obtaining consent, participants will be randomized to receive either 1 capsule
      containing probiotics, or 1 capsule of placebo daily for 60 days. Compared with the probiotic
      capsules, the placebo contains the same carrier material and is similar in size, shape and
      taste.
    

Intervention name(s): Probiotics; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
The Effect of Timing of Transcranial Direct Current Stimulation (tDCS) for Enhancing Learning During Cognitive Training
Condition: Effects on Learning
Study type: Interventional

Summary: 
      This project will investigate a novel strategy for enhancing cognitive training (CT).
      Specifically, the investigators aim to combine a non-invasive form of brain stimulation
      (tDCS) with CT. This study will examine the optimal time interval - whether tDCS should be
      administered either before or during CT.
    


Intervention name(s): Transcranial direct current stimulation (tDCS)
Intervention type(s): Device
Intervention description(s): Eldith Direct Current Stimulator (NeuroConn GmbH, Germany)
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Evaluation of a Photopneumatic System for the Treatment of Acne
Condition: Mild to Moderate Acne
Study type: Observational

Summary: 
      The purpose of the study is to evaluate the safety and efficacy of a photopneumatic therapy
      for the treatment of acne and concomitant symptoms associated with the disease, including
      erythema.
    

Detailed description: 
      The primary aims of the study will be to demonstrate the safety and efficacy of using a
      photopneumatic system for treatment of mild to moderate acne on the face or body - including
      neck, chest, and back - of up to 24 subjects. To support this clinical assessment, the
      affected areas to be treated will be documented at baseline, at each subsequent treatment
      visit (up to 6 treatments), and at one (1) month and three (3) months following final
      treatment.
    

Intervention name(s): Photopneumatic therapy
Intervention type(s): Device
Intervention description(s): Use of intense pulsed light (photo) in combination with vacuum technology (pneumatic) to treat mild to moderate acne.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        All genders and ethnic backgrounds. No subjects from vulnerable categories (i.e. minors,
        pregnant women, etc).
Internet Delivered CBT for OCD in Adolescents With ASD - A Clinical Case Series
Condition: Obsessive Compulsive Disorder; Autism Spectrum Disorder
MeSH terms: Autism Spectrum Disorder; Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Study type: Interventional

Summary: 
      The aim of this study is to test the feasibility and acceptability of an internet-delivered
      cognitive behavior therapy (ICBT) intervention originally developed for neurotypical
      adolescents with obsessive compulsive disorder (OCD) in adolescents with OCD and autism
      spectrum disorder (ASD). This feasibility study will inform us how to adapt the original
      intervention to the specific needs of patients with ASD.
    

Detailed description: 
      To evaluate the effectiveness of ICBT for OCD in adolescents with ASD, this study will use a
      single case experimental design with weekly measures during two phases: A-B. The A-phase will
      consist of baseline measures at least three weeks prior to treatment. The B-phase will
      consist of the 12 weeks ICBT-program as well as one measure post-treatment. Single case
      descriptions of each participant will be presented. Weekly measures on the Obsessional
      Compulsive Inventory - Child version (OCI-CV) will be analyzed through visual inspection of
      each participants graph and through computation of Percentage of Non-overlapping Data (PND).
      PND is a frequently used effect measure in SCED and reflects how large percentage of the
      measurements during the treatment-phase that do not overlap with any of the measurements
      during the base-line phase.

      To assess the feasibility and comprehension of the ICBT treatment semi-structured interviews
      (face-to-face or telephone) will be conducted with participants and parents weekly during the
      four first weeks of ICBT and semi-weekly during the rest of the treatment. Detailed notes
      will be taken during each interview and will serve as content material for a thematic
      analysis trying to determine possible accommodations to the ICBT protocol to better suit
      patients with ASD.
    

Intervention name(s): Internet-delivered Cognitive Behavior Therapy
Intervention type(s): Behavioral
Intervention description(s): The treatment consists of standard cognitive behavior therapy for obsessive-compulsive disorder and is delivered via an internet platform and regular therapist contact several times per week via email and telephone. The treatment is 12 weeks. Both parents and adolescents are involved in treatment. Parents will also receive three lectures on 1, Autism spectrum disorder, 2, CBT and functional analysis and 3, Parental strategies
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Cognitive Impairments in Children With Epilepsy
Condition: Epilepsy Syndrome
MeSH terms: Epilepsy; Epileptic Syndromes
Study type: Observational

Summary: 
      Since the proportion of language and attentional difficulties in patients with epilepsy is
      recognized, both in the literature and in the clinical experience of practitioners, it is
      appropriate to propose a complete speech-language assessment of oral language and
      attention.This study investigates these impairments through the taking of specific tests.

      The general objective of this study is to observe possible oral language and attention
      disorders in children with epilepsy, by age and etiology of epilepsy.

      The objective of this work is to study therapeutic apheresis (including plasma exchange and
      immunoadsorption) among french neuropediatric tertiary centers and to prove that this
      treatment modality is effective and well tolerated in pediatric neurology diseases.
    


Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Children with epilepsy followed by Dr COLMARD at the Montpellier hospital and university
        center
      
Keywords: Speech therapy; Neurology; Children; Oral language; Attention; Type of epilepsy (focal epilepsy or generalized epilepsy); Etiology of epilepsy (unknown, idiopathic, structural, metabolic, immune, infectious); Epilepsy syndrome