bioihbjkbjnl/mcl2 huggingface dataset:
Effect of Acetazolamide on Right Ventricular Function During Exercise in Patients With Respiratory Disease at Altitude
Condition: Chronic Obstructive Pulmonary Disease
MeSH terms: Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Study type: Interventional
Phase: Phase 4

Summary: 
      This trial will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on right
      ventricular function during exercise at acute altitude exposure in patients with COPD.
    

Detailed description: 
      This is a randomized, placebo-controlled, double-blind parallel trial evaluating the effect
      of acetazolamide (375 mg per day) vs. placebo on right ventricular function during exercise
      in lowlanders with chronic obstructive pulmonary disease travelling to altitude. Participants
      living in the Bishkek area, Kyrgyzstan (760m), will be transferred by car within 4h to the
      Tuja Ashu high altitude clinic (3200 m), and stay there for 2 days. Acetazolamide 375mg/day
      (or placebo) will be administered 24 hours before departure at 760 m and during the stay at
      altitude. Outcomes will be assessed during the stay at 3200 m.

      Right ventricular function will be assessed during graded cycling on an ergometer by
      transthoracic echocardiography.
    

Intervention name(s): ACETAZOLAMIDE oral capsule; Placebo oral capsule
Intervention type(s): Drug; Drug
Intervention description(s): Administration of 125mg acetazolamide in the morning, 250mg in the evening, starting 24 hours before departure to 3200m; Administration of equally looking placebo capsules in the morning and evening, starting 24 hours before departure to 3200m
Intervention MeSH terms: Acetazolamide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: exercise; echocardiography; right ventricular function; obstructive airway disease; emphysema; acetazolamide; altitude
Glucose and Fructose Stimulated Brain Activity in Obese Subjects Before and After Bariatric Surgery
Condition: Exploratory Behavior
Study type: Interventional

Summary: 
      The objective is to investigate neuro-anatomical correlates of the regulation of energy
      intake by means of functional MRI before and after bariatric surgery. Administration of
      glucose as well as fructose is followed by functional brain MRI, and findings are correlated
      with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese
      humans.
    


Intervention name(s): Tap water; Glucose; Fructose
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): 300ml tap water via nasogastric tube; 300ml tap water with 75g glucose via nasogastric tube; 300ml tap water with 25g fructose via nasogastric tube
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Basic Science
Dose Ranging Study of Combined Haemophilus Influenzae Type B-Meningococcal Serogroups CY (Hib-MenCY-TT) Vaccine
Condition: Haemophilus Influenzae Type b; Neisseria Meningitidis
MeSH terms: Influenza, Human; Haemophilus Infections
Study type: Interventional
Phase: Phase 2

Summary: 
      This study evaluated the safety and immunogenicity of 3 formulations of Hib-MenCY-TT vaccine
      compared to 2 control groups receiving licensed meningococcal serogroup C conjugate vaccine
      and/or licensed Hib conjugate vaccine administered at 2, 4, and 6 months of age. Antibody
      persistence and immune responses to polysaccharide vaccine boosters were additionally
      assessed at 11 to 14 months of age.
    


Intervention name(s): Hib-MenCY-TT vaccine (MenHibrix); Meningitec®; ActHIB®; Infanrix® Penta; Prevenar®; Mencevax® ACWY; PRP (Polyribosyl Ribitol Phosphate)
Intervention type(s): Biological; Biological; Biological; Biological; Biological; Biological; Biological
Intervention description(s): Three doses were administered intramuscularly (IM) in left thigh at Months 0,2 and 4 respectively; Three doses were administered IM in right lower thigh at Months 0,2 and 4.; Three doses were administered IM in left thigh at Months 0,2 and 4.; Three doses were administered IM in right upper thigh at Months 0,2 and 4 respectively.; Three doses were administered IM in right lower thigh at Months 0,2 and 4 respectively.; One fifth of one dose was administered IM in deltoid region of right arm at Month 10 as booster.; One dose was administered IM in deltoid region of left arm at Month 10 as booster.
Other intervention name(s): DTPa-HBV-IPV vaccine
Intervention MeSH terms: Vaccines; Heptavalent Pneumococcal Conjugate Vaccine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Prevention
Keywords: Invasive bacterial disease caused by Hib; Neisseria meningitidis serogroups C & Y
Picosure Alexandrite Laser for the Treatment of Unwanted Tattoos
Condition: Unwanted Tattoos
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the Picosure Laser System for the treatment of
      unwanted tattoos.
    


Intervention name(s): Picosure Laser System
Intervention type(s): Device
Intervention description(s): Picosure Laser System for the Treatment of Unwanted Tattoos
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Evaluation of the 755nm Alexandrite Laser for Skin Toning and Epidermal Pigmented Lesions in Asian Skin Types
Condition: Epidermal Pigmented Lesions; Skin Toning
Study type: Interventional

Summary: 
      The purpose of this study is to assess treatment for facial skin toning and removal of
      epidermal pigmented lesions for Asian patients using the 755nm Alexandrite laser
    


Intervention name(s): 755nm Alexandrite Laser
Intervention type(s): Device
Intervention description(s): 755nm Alexandrite laser for treatment of epidermal pigmented lesions and skin toning in Asian skin types
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants are put into two groups (Pigmented Lesions/Skin Toning) to test prototype design and operating specifications. It is not a full clinical trial.
Masking: None (Open Label)
Primary purpose: Device Feasibility
Evaluation of the Pharmacokinetics and Safety of VX-548 in Participants With Mild or Moderate Hepatic Impairment
Condition: Pain
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the pharmacokinetics and safety of multiple doses of
      VX-584 in participants with mild or moderate hepatic impairment as compared to matched
      healthy controls.
    

Detailed description: 
      This clinical trial information was submitted voluntarily under the applicable law and,
      therefore, certain submission deadlines may not apply. (That is, clinical trial information
      for this applicable clinical trial was submitted under section 402(j)(4) (A) of the Public
      Health Service Act and 42 CFR 11.60 and is not subject to the deadlines established by
      sections 402(j)(2) and (3) of the Public Health Service Act or 42 CFR 11.24 and 11.44.).
    

Intervention name(s): VX-548
Intervention type(s): Drug
Intervention description(s): Tablets for oral administration.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Individualized Exercise Program for Treatment of Fatigue in Patients After Hematologic Stem Cell Transplant (HSCT)
Condition: Fatigue
MeSH terms: Fatigue
Study type: Interventional

Summary: 
      The purpose of this study is to investigate the impact of fatigue in severely affected
      transplant patients.
    

Detailed description: 
      Investigates impact of a monitored program in kinesiology lab at the University of Calgary on
      fatigue in severely affected transplant patients.
    

Intervention name(s): exercise
Intervention type(s): Behavioral
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: transplant; fatigue; exercise; Malignant disease
Additional Effect of Visual Feedback Along With AOT on Balance,Mobility and Cognition in CP
Condition: Cerebral Palsy
MeSH terms: Cerebral Palsy
Study type: Interventional

Summary: 
      the study aims to find the effectiveness of visual feedback along with action observation
      therapy in cerebral palsy. the effect of AOT on mobility, cognition and balance of the
      targeted population will be the intrest of the researcher
    


Intervention name(s): Action Observation Therapy; Action Observation Therapy along with visual feedback
Intervention type(s): Other; Other
Intervention description(s): Exercises of AO protocol MOVEMENT TOTAL VIDEO TIME PATIENT TIME Upright the pelvis 1 minute 5 minutes Move weight forward 1 minute 5 minutes Move weight to the left and right 1 minute 5 minutes Rotate right and left 1 minute 5 minutes Upright the pelvis in sitting position 1 minute 5 minutes Move weight forward from a sitting position 1 minute 5 minutes Stand up from a sitting position 1 minute 5 minutes Move weight right and left 1 minute 5 minutes Forward weight shift with right foot and left foot 1 minute 5 minutes Walking sideways to left 1 minute 5 minutes Walking sideways to right 1 minute 5 minutes
Rest time between watching and performing each video will be 1 minute. the exercises will be done 3 times a week.; Exercises of AO protocol in front of a mirror MOVEMENT TOTAL VIDEO TIME PATIENT TIME Upright the pelvis 1 minute 5 minutes Move weight forward 1 minute 5 minutes Move weight to the left and right 1 minute 5 minutes Rotate right and left 1 minute 5 minutes Upright the pelvis in sitting position 1 minute 5 minutes Move weight forward from a sitting position 1 minute 5 minutes Stand up from a sitting position 1 minute 5 minutes Move weight right and left 1 minute 5 minutes Forward weight shift with right foot and left foot 1 minute 5 minutes Walking sideways to left 1 minute 5 minutes Walking sideways to right 1 minute 5 minutes
Rest time between watching and performing each video will be 1 minute. the exercises will be done 3 times a week.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: action observation therapy; cerebral palsy; visual feedback
Part-time Versus Full-time Spectacles for Myopia Control (ParMA Study)
Condition: Myopia
MeSH terms: Myopia
Study type: Interventional

Summary: 
      The purpose is to assess the effect of part-time compared to full-time spectacle use in
      juvenile myopia control.
    

Detailed description: 
      A prospective, randomized, controlled clinical trial was designed for assessing the effect of
      single-vision spectacles on myopic progression. 30 myopic subjects, aged 6-16 years old, with
      a spherical equivalent refraction between -0.50D and -6.00D, were recruited. A random number
      table was used to allocate participants into either a) part-time use of single-vision
      spectacles, or b) full-time use of single-vision spectacles. Part-time use was for 4-6 hours
      a day, 7 days a week for a year. Clinical assessment included follow-up at 6 months and at 12
      months upon allocation. The primary outcomes were a) change in spherical equivalent
      refraction (SER) measured by cycloplegic autorefraction, and b) change in axial eye length
      (AL). The secondary outcomes were a) change in choroidal thickness (ChT), and b) assessment
      of the subjective tolerance.
    

Intervention name(s): Single-Vision Spectacles
Intervention type(s): Device
Intervention description(s): Spectacle correction for myopia treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Myopia; Spectacles; Full-time correction; Part-time correction; Childhood
Structured Education and Multidisciplinary Team
Condition: Pain; Anxiety; Activities of Daily Living
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      It is well-known that pre-operative education has a positive effect on patient recovery. This
      study was conducted to evaluate the impact of structured education given by a
      multidisciplinary team (surgeon, anesthesiologist, and nurse) on pain, anxiety, and
      activities of daily living in patients undergoing laparoscopic cholecystectomy.
    

Detailed description: 
      In this randomized controlled study was conducted with 60 patients undergoing elective
      laparoscopic cholecystectomy in a training and research hospital in Turkey between March and
      August 2019. The participants were divided into two equal groups. Verbal structured education
      and written documents were given to the training group before surgery by a multidisciplinary
      team. The control group had the routine education. Data were collected using a Patient
      Information Form, the State Anxiety Inventory, a visual analog scale, and the Barthel Index
      for Activities of Daily Living.
    

Intervention name(s): Education Group
Intervention type(s): Other
Intervention description(s): The patients in the training group were given structured training by a multidisciplinary team. After the content of the structured education was prepared, three experts were consulted for their opinions in terms of the scope and content. Necessary adjustments were made in line with their recommendations. Patients in this group were visited in their rooms at least 12 hours before undergoing surgery by a multidisciplinary team consisting of a surgeon, an anesthesiologist, and a nurse. The multidisciplinary team visited the patients at the same time and provided their education after introducing the team. Structured verbal education and written documents were given to the patients for 30 minutes on preoperative preparation, anesthesia, intubation, mobilization, deep breathing and coughing exercises, nutrition and fluid management, the postoperative recovery process, clinical practice guideline and operating room protocols.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: anxiety; cholecystectomy; education; multidisciplinary team; pain
This Study Performed to Develop a New Technique for Measuring the Intra Abdominal Pressure
Condition: Abdominal Compartment Syndrome
MeSH terms: Compartment Syndromes; Intra-Abdominal Hypertension
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the changes of intraocular pressure due to the
      increase of intra abdominal pressure.
    

Detailed description: 
      In this prospective study, 40 patients undergoing elective surgery were included. Patients
      were divided into four groups of 10 patients. The control group (Group C) was not subjected
      to laparoscopic intervention. Laparoscopic surgery was respectively performed with an
      intra-abdominal pressure of 9, 12 and 15 mmHg in Groups L (low), M (medium), and H (high
      pressure). Intraocular pressure was measured binocularly in each patient at three different
      time (before, during and end of surgery) using a contact tonometer.
    

Intervention name(s): Intraocular pressure measurement with 9 mmHg insufflation; Intraocular pressure measurement with 12 mmHg insufflation; Intraocular pressure measurement with 15 mmHg insufflation
Intervention type(s): Other; Other; Other
Intervention description(s): Comparison of intraocular pressure levels at different abdominal pressure; Comparison of intraocular pressure levels at different abdominal pressure; Comparison of intraocular pressure levels at different abdominal pressure
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Intra-abdominal pressure,; intraocular pressure,; abdominal hypertension,; laparoscopy,; critical care
Evaluate the Working Environments of Individuals Working From Home During Covid-19 Outbreak
Condition: Musculoskeletal Pain
MeSH terms: Musculoskeletal Pain
Study type: Observational

Summary: 
      The study aims to evaluate the working environments of individuals working from home during
      the covid-19 outbreak and the effect of the working environments on their musculoskeletal
      system.
    

Detailed description: 
      The study will include people between the ages of 18-65 who work from home (works in the
      office before isolation) as a part of the Covid-19 isolation measure. The working environment
      of the individuals participating in the study will be evaluated with The Rapid Office Strain
      Assessment (ROSA). Musculoskeletal symptoms will be analyzed by using the Standardised Nordic
      Questionnaires (NMQ). Pain will be analyzed by using the Visual Analogue Scale (VAS) .
    

Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        The study will include people between the ages of 18-65 who works from home (works in the
        office before isolation) as a part of Covid-19 isolation measure
Efficacy of a Prebiotic Galactooligosaccharide to Reduce Metabolic Syndrome Risk Factors in Overweight Adults
Condition: Metabolic Syndrome X
MeSH terms: Overweight; Metabolic Syndrome; Syndrome
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The traditional risk factors for obesity are inappropriate diet, lack of exercise and genetic
      factors. However, recent observations have involved gut microbiota profiles as having an
      additional influence. In this case, there exists the possibility to modulate this through
      diet. Research has shown that the gut microbiota of both obese humans and mouse models of
      obesity is altered towards less beneficial one compared to lean counterparts. This raises the
      possibility of modulating the gut microbiota as a novel strategy in tackling the epidemic of
      obesity and diabetes sweeping the developed world. In addition, a more direct effect of
      high-fat induced disruption of the intestinal microbiota has also been seen with a murine
      model. Elevated circulating levels of lipopolysaccharide (LPS) a major building block and
      antigen of Gram-negative bacteria, was shown to generate a low grade chronic inflammation,
      termed metabolic endotoxemia, which then onsets insulin resistance. High-fat diets were shown
      to disrupt the Gram-negative intestinal populations of these animals, liberating LPS. The
      effects of prebiotics on the microbiota or metabolic syndrome (combination of disorders that
      increase the risk of developing cardiovascular disease and diabetes) in overweight adults
      have not been investigated thus far. The investigators therefore propose to investigate the
      effect of galactooligosaccharide (GOS) on the faecal microbiota and metabolic syndrome risk
      factors in overweight adults in a double-blind, randomised, placebo controlled, cross-over
      trial.
    


Intervention name(s): Bimuno; Maltodextrin
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): 5.5g daily intake; 5.5g daily intake
Other intervention name(s): Galactooligosaccharide; Dexrins
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
The Effect of Weight on Vitamin D Dose Response
Condition: Obesity; Vitamin D Deficiency
MeSH terms: Vitamin D Deficiency
Study type: Interventional

Summary: 
      Vitamin D3 is a vitamin that is an essential component of biological regulating systems in
      humans. Sun exposure is the predominant source of vitamin D3. Previous research has shown
      that vitamin D3 deficiency is common worldwide. It is especially common in northern countries
      with long winters due to inadequate sun exposure during winter. In the US, an estimated 36%
      to 57% of healthy middle-aged to elderly adults have vitamin D3 deficiency. Current research
      indicates that obesity is associated with a low vitamin D3 level.
    

Detailed description: 
      Obesity is a known risk factor for vitamin D deficiency. Adequate levels of vitamin D are
      important, not only for bone health, but appear to be important for prevention of certain
      autoimmune diseases, infections and cancers. Current FDA recommendations for vitamin D intake
      do not differentiate between lean and obese people. There are no published studies indicating
      if the 25(OH)D response to a given daily dose of vitamin D is any less in an obese person
      than a normal weight person. The purpose of this study is to characterize the quantitative
      relationship between steady state cholecalciferol input and the resulting serum 25 (OH)D
      concentration in obese subjects. Data obtained in this study will be compared to published
      normative data for non-obese subjects. Recommendations will be provided for optimal treatment
      of vitamin D deficiency in obese men and women.
    

Intervention name(s): cholecalciferol
Intervention type(s): Dietary Supplement
Intervention description(s): daily dose
Intervention MeSH terms: Cholecalciferol; Vitamin D
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: vitamin D
Effect of Refnot on Immunity in Cancer Patients
Condition: Solid Tumor
Study type: Interventional
Phase: Phase 2

Summary: 
      The study was planned to include disseminated patients with various solid tumors (melanoma,
      soft tissue sarcoma, breast cancer, colon cancer, etc.). The study drug was administered
      subcutaneously at a dose of 400,000 IU once a day, 3 times a week (every other day), for 4
      weeks. In the absence of disease progression - an additional 4 weeks.
    

Detailed description: 
      The study was planned to include 50 disseminated patients with various solid tumors. The
      patients were divided into 2 groups: 1 - Refnot, monotherapy, 2 - Refnot together with
      chemotherapy.

      Refnot is administered at a dose of 400,000 IU subcutaneously 3 times a week for 4 weeks. 4
      weeks constitute 1 course of treatment with Refnot. Immediately before use, 1 ml of water for
      injection is added to 4 vials (100,000 IU each) or to a vial containing 400,000 IU. After
      dilution, the drug is injected subcutaneously into the outer surface of the shoulder or
      thigh. Injection sites should alternate. In the absence of progression of the disease - an
      additional 4 weeks. Chemotherapy may be used after 4-8 weeks of Refnot use.
    

Intervention name(s): Tumor necrosis factor-thymosin alfa 1 recombinant (TNF-T); Tumor necrosis factor-thymosin alfa 1 recombinant (TNF-T) and chemotherapy
Intervention type(s): Drug; Drug
Intervention description(s): has a direct antitumor effect in vitro and in vivo on various tumor cell lines; Refnot has a direct antitumor effect in vitro and in vivo on various tumor cell lines, chemotherapy has a cytostatic and cytotoxic effect.
Other intervention name(s): Refnot; Tumor necrosis factor-thymosin alfa 1 recombinant; and Dacarbazine, Lomustine, Cisplatin
Intervention MeSH terms: Cisplatin; Dacarbazine; Lomustine; Thymalfasin
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: solid tumors; Refnot