bioihbjkbjnl/mcl2 huggingface dataset:
An Evaluation of Brief Online Hypnosis for Migraine and Tension-type Headaches
Condition: Migraine; Tension-Type Headache
MeSH terms: Migraine Disorders; Tension-Type Headache; Headache
Study type: Interventional

Summary: 
      This study aims to conduct an initial evaluation of whether a single, online, group-based
      session of hypnosis followed by self-hypnosis can decrease symptoms of migraine and
      tension-type headaches as well as improve quality of life and perceived self-efficacy over
      the condition.
    

Detailed description: 
      This study is a pilot randomised controlled trial (RCT) comparing a single, online,
      group-based session of hypnosis followed by self-hypnosis for people with migraines or
      tension-type headaches with a wait-list control. A battery of self-report measures and a
      2-week headache diary will be administered online at baseline (weeks 0 and 1),
      post-intervention (weeks 7 and 8) and at follow-up (weeks 11 and 12).
    

Intervention name(s): Hypnosis.; Usual care
Intervention type(s): Behavioral; Other
Intervention description(s): Online, group-based, single session hypnosis workshop followed by 2 weeks of self hypnosis.; Participants will be asked to continue with whatever interventions they are already receiving/employing to manage their migraine and tension-type headaches.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Effect of Orally Administrated Nitrate on Renal Parameters and Systemic Haemodynamics
Condition: Hypertension
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      Treatment with nitrate has shown to lower blood pressure in both healthy subjects and
      hypertensive patients.Beside this nitrate have also shown to decrease arterial stiffness and
      improve endothelial function.But the effect of nitrate on renal blood flow, kidney function,
      water and salt balance and vasoactive hormones is still unclear.

      Therefore, the purpose of this study is to investigate the effect of orally administered
      nitrate on these parameters.

      This will be done in a double-blinded, placebo-controlled, crossover study. 20 healthy
      subjects will be treated, in a randomized order, with both potassium nitrate and placebo
      separated by at least 4 weeks wash-out.
    

Detailed description: 
      Inorganic nitrate reduces blood pressure and improves endothelial function in both healthy
      subjects and hypertensive patients.

      This effect is thought to be caused through bioconversion to nitric oxide. Thus improving
      risk factors of cardiovascular decease by increasing vasodilatation, salt regulation and
      vasoactive hormones.The purpose of this study is to investigate the effect of inorganic
      nitrate on kidney function, hormones and circulation, which is still unknown.

      The effect of 4 days treatment with 24 mmol potassium nitrate capsules on heart rate, blood
      pressure, vasoactive hormones and urinary excretion of sodium and water will be measured in a
      randomized, placebo controlled, double blinded, crossover study in 20 healthy subjects. Each
      subject attends 2x2 examination days at least 4 weeks apart. The examination days are divided
      into 8 clearance periods of 30 min. each. The first 3 are baseline periods and in period 4 1
      Liter of saline is administered to detect any difference in renal parameters after NaCl load.

      If inorganic nitrate supplementation is found to lower blood pressure in addition to
      favorable renal effects, it could lead to changes in the general treatment of high blood
      pressure and cardiovascular disease.
    

Intervention name(s): isotonic saline 9%; Potassium nitrate; Potassium chloride
Intervention type(s): Other; Dietary Supplement; Dietary Supplement
Intervention description(s): 1 Liter of Isotonic saline administered I.V.; 24 mmol of Potassium nitrate is the active comparator substance, that is ingested every morning for 4 days before and on the examination day.; 24 mmol of Potassium nitrate is the placebo substance, that is ingested every morning for 4 days before and on the examination day.
Other intervention name(s): Sodium Chloride 9%
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: double-blinded, placebo-controlled, crossover study
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Efficacy, Safety and Tolerability of Different Bowel Preparation Before Colonoscopy in Children Over 2 Years Old
Condition: Child Obesity; Bowel Preparation
MeSH terms: Pediatric Obesity
Study type: Interventional

Summary: 
      Electronic colonoscopy plays an important role in the diagnosis and follow-up of intestinal
      diseases in children.
    

Detailed description: 
      The adequacy of bowel preparation before colonoscopy is particularly important for the
      visualization of intestinal mucosa under colonoscopy. Some studies have shown that bowel
      preparation must be customized according to the age, weight and clinical status of the child.
      However, there is no internationally recognized standard scheme for pediatric intestinal
      reserve. In pediatric clinical trials, polyethylene glycol with electrolyte solution
      (PEG-ELS) is more effective than bisacodyl, folium sennae and magnesium citrate. PEG-ELS is
      an electrolyte balanced isotonic solution, which can be used to clean the intestinal tract by
      large volume irrigation. Polyethylene glycol 4000 is a long-chain linear polymer, which can
      hardly absorb and decompose after oral administration. It can effectively increase the
      composition of intestinal fluid, stimulate intestinal peristalsis, cause watery diarrhea, and
      achieve the purpose of cleaning the intestine. The inorganic salt composition and proper
      amount of water in the formula ensure the balance of water and electrolyte exchange between
      intestinal tract and body fluid. In this study, PEG-ELS short protocol and long protocol were
      selected for intestinal preparation, and the effectiveness and safety of different intestinal
      preparation protocols under electronic colonoscopy for children over 2 years old were
      compared.
    

Intervention name(s): PEG-ELS-S; PEG-ELS-L
Intervention type(s): Other; Other
Intervention description(s): 2/3 dose of PEG-ELS was taken orally from the evening on the day before colonoscopy, and the remaining 1/3 dose of PEG-ELS was orally administered in the morning of the next day.; PEG-ELS is given orally on the day before colonoscopy, which is divided into 10-12 portions and taken one portion every hour. If half of the total amount is not completed at afternoon ward round the day before colonoscopy, nasogastric feeding is recommended.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Other
Keywords: Child; Electronic colonoscopy; bowel preparation; polyethylene glycol with electrolyte solution
Construction of Microfluidic Exosome Chip for Diagnosis of Lung Metastasis of Osteosarcoma
Condition: Osteosarcoma; Pulmonary Metastases
MeSH terms: Neoplasm Metastasis; Osteosarcoma; Lung Neoplasms
Study type: Observational

Summary: 
      Use exosome microfluidic chips to establish a combination of exosome subgroup level (exosome
      barcode) markers for the early diagnosis of osteosarcoma lung recurrence, and establish the
      basis of microfluidic chip based exosome biomarker for monitoring the early therapeutic
      response of the second-line therapy for recurrent osteosarcoma.
    

Detailed description: 
      Osteosarcoma is the most common primary malignant bone tumor in adolescents, and lung
      metastasis is the main cause of its poor prognosis. Our previous data on the basis of
      second-line chemotherapy combined with VEGFRi targeted therapy for patients with lung
      metastases from osteosarcoma showed that some patients with early diagnosis of lung
      metastases may achieved long-term tumor-free survival upon prompt treatment. However, plasma
      biomarker for the early detection of recurrent osteosarcoma is still lacking to date. Our
      preliminary studies indicate that exosome is a potential source of liquid biomarker for the
      early diagnosis of osteosarcoma lung metastasis. We, therefore, have developed a microfluidic
      biochip based on nano-zinc oxide microcolumns. This chip can quickly and efficiently screen
      and capture exosomes and achieve quantitative and qualitative detection of exosome and its
      subgroups. This technology may be able to achieve early sensitive exosome quantification for
      lung metastasis of osteosarcoma. But the clinical efficacy and utility of the microfluidic
      chip based exosome detection for the early diagnosis osteosarcoma recurrence remains to be
      validated.

      This research plan uses our newly developed microfluidic chip technology to capture and
      efficiently capture exosomes for quantitative and qualitative and marker screening, and
      establish a combination of exosome subgroups level as a biomarker for the early diagnosis of
      osteosarcoma lung metastasis.
    

Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        1. Surgical specimens and peripheral blood specimens of previous patients with
             osteosarcoma in the specimen bank,

          2. Patients who were diagnosed with osteosarcoma and were hospitalized in the Department
             of Orthopedics of Ruijin Hospital
Treatments of Acquired Apraxia of Speech
Condition: Aphasia; Apraxia of Speech; Stroke
MeSH terms: Aphasia; Apraxias
Study type: Interventional

Summary: 
      This study was designed to examine the effects of speech therapy on ability to produce speech
      sounds in persons with acquired apraxia of speech.
    

Detailed description: 
      This study was designed to investigate the effects of Sound Production Treatment (SPT; a
      treatment for acquired apraxia of speech) on sound production accuracy in persons with
      chronic apraxia of speech (AOS). Organization of practice (blocked practice or randomized
      practice) will be manipulated in an effort to determine the most efficacious application of
      SPT. A combination of group and single-subject experimental designs wasl be completed with 20
      speakers with AOS (2 groups of 10 participants).
    

Intervention name(s): Sound Production Treatment - Blocked; Sound Production Treatment - Random
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Sound Production Treatment is a treatment for acquired apraxia of speech. Combines therapist modeling, simultaneous production, articulatory instruction, feedback and repeated practice. SPT-Blocked entailed practicing all treatment targets blocked by target. SPT-Random entailed practicing all treatment targets in a non predictable, random order.; A treatment for acquired apraxia of speech. Combines therapist modeling, simultaneous production, articulatory instruction, feedback and repeated practice. SPT-Random entailed practicing treatment targets in a non predictable order. SPT-Blocked entailed practicing treatment targets blocked by target.
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Intervention model description: Each participant received each arm of treatment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: speech; speech therapy; apraxia of speech
Metabolic Effects of Non-nutritive Sweeteners
Condition: Obesity
Study type: Interventional

Summary: 
      The purpose of this research study is to examine whether sugar-replacement sweeteners that
      are currently on the market (ex. Sucralose, which is in Splenda) change how well the body
      works to control blood sugar.
    

Detailed description: 
      The investigators of this study have recently found that sucralose, the most commonly used
      non-nutritive sweetener (NNS), affects the glycemic response to an oral glucose tolerance
      test (OGTT) and potentiates glucose-stimulated insulin secretion in obese people who are not
      regular consumers of NNS. However, studies conducted in healthy lean adults, none of which
      control for previous use of NNS, show that sucralose does not affect glycemic or hormonal
      responses to the ingestion of glucose or other carbohydrates. Therefore, we do not know a)
      whether sucralose effects are limited to obese subjects, or are generalizable to lean people
      when controlling for prior history of NNS consumption, and b) mechanism(s) responsible for
      the acute effect of sucralose on glucose metabolism as we measured in obese subjects. The aim
      of this study is to determine the effects of an acute intake of sucralose on the metabolic
      response to an oral glucose tolerance test in lean and obese people.
    

Intervention name(s): Sucralose; Water; glucose load
Intervention type(s): Dietary Supplement; Other; Dietary Supplement
Intervention description(s): 60 ml of 2mM sucralose; 60 ml of water
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: sucralose
A Study of SARS CoV-2 Infection and Potential Transmission in Individuals Immunized With Moderna COVID-19 Vaccine
Condition: SARS-CoV-2 Infection
MeSH terms: Infections; Communicable Diseases; COVID-19
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to assess SARS CoV-2 infection, viral shedding, and subsequent
      potential transmission in individuals immunized with the Moderna COVID-19 vaccine.
    

Detailed description: 
      This study will evaluate the efficacy of the Moderna COVID-19 vaccine against SARS-CoV-2
      infection, as well as its effect on peak nasal viral load as a measure of infection and a
      proxy of infectiousness, in adults aged 18-29.

      In the Main study, up to 12,000 participants will be randomized 1:1 to Immediate Vaccination
      Group 1 (at Months 0 and 1) or Standard of Care Group 2, with vaccination given at Months 4
      and 5 if not received off-study previously. Up to an additional 6,000 participants will be
      enrolled into the Vaccine Declined Group 3 and will also be offered vaccine at Months 4 and
      5.

      Additional study visits for Group 1 will occur at Months 2 and 4; for Groups 2 and 3, at
      Months 0 and 2. Study visits may include medical history, vaccine injections, blood
      collection, nasal swab, SARS-CoV-2 screening, COVID-19 symptom check, and questionnaires.

      In addition to the main study participants, the study will also evaluate infectiousness
      following close contacts with main study participants. Study procedures for close contacts
      include questionnaires and blood samples; for those who become SARS-CoV-2 infected, study
      procedures will also include nasal swabs.
    

Intervention name(s): Moderna COVID-19 Vaccine
Intervention type(s): Biological
Intervention description(s): A lipid nanoparticle (LNP) dispersion of a messenger ribonucleic acid (mRNA) encoding the prefusion stabilized S protein of SARS-CoV-2 formulated in LNPs composed of 4 lipids (1 proprietary and 3 commercially available). It is a suspension for intramuscular injection administered as a series of two doses (0.5 mL each) 1 month apart.
Other intervention name(s): mRNA-1273
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: SARS-CoV-2
A Single High-dose Oral Supplement of Vitamin D in Young Chinese
Condition: Vitamin D Deficiency
MeSH terms: Vitamin D Deficiency
Study type: Interventional

Summary: 
      evaluated the effect and safety of a single high dose of cholecalciferol in Chinese young
      people.
    


Intervention name(s): vitamin D3
Intervention type(s): Dietary Supplement
Intervention MeSH terms: Vitamin D; Cholecalciferol
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Prolectin-M in COVID-19 Patients Having Mild to Moderate Symptoms Not Requiring Oxygen Support.
Condition: COVID-19
MeSH terms: COVID-19
Study type: Interventional

Summary: 
      A randomised controlled trial of open label Prolectin-M; a (1-6)-alpha-D-Mannopyranose among
      patients with RT PCR positive COVID-19 patients.
    

Detailed description: 
      SarsCoV2 has infected over 20 million people worldwide. The virus has a unique protein
      structure enabling it to rapidly infect and spread among the population. COVID19 is a global
      health emergency and has affected lives of all people irrespective of being infected. There
      are no proven therapies and a vaccine is yet to be approved for wide public usage.

      Our study aims to test a hypothesis of physically blocking the spike protein from infecting
      the human cells, thus promoting its rapid excretion from the infected person.

      We will randomise 10 subjects in this proof of concept trial and test the hypothesis by
      measuring the effect of Prolectin-M; a (1-6)-alpha-D-Mannopyranose in reducing the viral copy
      numbers over 5 days of treatment. The absolute copy numbers will be measured on digital
      droplet PCR developed by BioRad. A fall in copy numbers by 2-fold from baseline will be
      considered a positive treatment effect in this population. All standard care measures
      currently being practiced for these patients will be continued.
    

Intervention name(s): Prolectin-M; a (1-6)-alpha-D-Mannopyranose class; Standard of Care
Intervention type(s): Other; Other
Intervention description(s): A treatment to decrease viral load, detected through digital droplet PCR, in mild to moderate cases of RT-PCR positive COVID-19; Currently approved standard of care for patients without symptoms requiring hospitalisation will be provided to all.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: ddPCR,; SarsCoV2 Copies
Sonification Embodied Associations
Condition: Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Sclerosis
Study type: Interventional

Summary: 
      The objective of this study to investigate, if learning and recall of a sequence of body
      movements (steps that realize a pattern on the ground) can be improved by self-produced music
      (having particular melodic-structures in relation to the pattern), compared to the same sound
      (a single tone) for each pattern in persons with multiple sclerosis compared to age and
      gender matched controls
    


Intervention name(s): learning and recall of a sequence of body movements
Intervention type(s): Other
Intervention description(s): The objective of this study to investigate, if learning and recall of a sequence of body movements (steps that realize a pattern on the ground) can be improved by self-produced music (having particular melodic-structures in relation to the pattern), compared to the same sound (a single tone) for each pattern in persons
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
A Fourteen-Week Placebo-Controlled Dose-Response Efficacy and Safety Study of NS 2330 in Early Parkinson's Disease Patients (Study for Proof of Concept in Early Parkinson's Disease of a Triple Reuptake Inhibitor, NS 2330 / SCEPTRE)
Condition: Parkinson Disease
MeSH terms: Parkinson Disease
Study type: Interventional
Phase: Phase 2

Summary: 
      To demonstrate efficacy and dose-response of NS 2330 versus placebo in patients with early
      Parkinson's Disease in 14 weeks of treatment, and to investigate the safety and tolerability
      of NS 2330 in these patients.
    


Intervention name(s): NS 2330
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Variability of Movement on an Altered Inertial Dynamics Task
Condition: Older Adults; Fall Patients
Study type: Interventional

Summary: 
      The overall goal of this research is to compare the effects of two different exercise
      programs on gait function in older adults. The investigators want to determine if
      participation in lateral stepping exercise program for six weeks will improve gait functions
      compared to forward walking exercise program.
    

Detailed description: 
      The overall goal of this research is to compare the effects of two different exercise
      programs on gait function in older adults. It is expected that improved control of foot
      placement in the lateral stepping task will transfer to improved control during typical
      forward walking. Moreover, it is expected that lateral stepping gait training will have a
      greater effect on recurrent fallers older adults than on the non-fallers older adults and
      young adults. It is also expected that the above beneficial results will be retained in a
      follow-up test six weeks after completion of the intervention and will result in improvements
      in common clinical balance tests that are used to assess fall risk. Therefore, in the current
      proposal, older adults aged 65 years of age and over are being asked to participate.
    

Intervention name(s): Lateral stepping; Forward walking
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Subjects will step laterally, changing direction every 10 m, thus alternating lead and lag limbs.; Subjects will have a typical forward walking
Other intervention name(s): Sideways walking; Typical walking
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Older adults will be screened and will be randomly assigned to three groups - (i) non-fallers, (ii) recurrent fallers - control group, and (iii) recurrent fallers - intervention group. A fourth group consisted of healthy young adults. This group will receive lateral stepping intervention and outcomes will be measured as a reference.
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: balance; gait; variability
Study to Investigate the Safety and Pharmacokinetic Characteristics of LC28-0126 in Healthy Male Subjects
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      To investigate the safety, tolerability and pharmacokinetic characteristics of LC28-0126 in
      healthy male subjects
    


Intervention name(s): LC28-0126; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): LC28-0126; Placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Relationship Between Bladder Distention and Hysteroscopy Application
Condition: Menorrhagia
MeSH terms: Menorrhagia; Urinary Retention
Study type: Interventional

Summary: 
      The purpose of the study is to investigate the advantages and disadvantages of bladder
      filling during hysteroscopy procedure.
    

Detailed description: 
      Women who should have diagnostic hysteroscopy procedure will be randomly allocated into two
      groups. In the first group hysteroscopy will be performed with a filled bladder and in the
      second group procedure will be performed with an empty bladder. The women will be assigned
      into groups randomly. The duration of the procedure, feasibility of the procedure and
      tolerability of procedure will be recorded.
    

Intervention name(s): Hysteroscopy
Intervention type(s): Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Diagnostic
Keywords: Hysteroscopy; Bladder; Pain; Feasibility; Duration