Effect of Photobiomodulation in a Partial Thickness Autogenous Skin Graft Donor Area
Condition: Healing Wound
Study type: Interventional

Summary: 
      This is a clinical study with a controlled series of cases, whose objectives were: to
      evaluate the effects of FBM, using LED, on the repair process of the skin graft donor area
      treated with Membracel® and LED versus Membracel ®; to evaluate the evolution of the quality
      of the aspects of the skin donor area, through the score obtained by the modified
      Bates-Jensen Scale; the intensity of the pain reported by the participants; the size of the
      wound area until the 7th postoperative (PO) period and the time for re-epithelialization of
      the donor area. Data collection was performed at the Burn Unit of the General Hospital "Dr.
      José Pangella", from Vila Penteado, São Paulo, Brazil. The sample consisted of 21
      participants and 25 donor areas, 13 of which were from the control group, which received only
      conventional treatment (Membracel®) and 12 from the experimental group: Membracel® and LED.
      Data collection instruments were used: medical records of the participants, anamnesis and
      physical examination, the scales: pain (Visual Analogic Scale - VAS) and Bates-Jensen to
      accompany the re-epithelialization process and the measurement of donor skin areas in the
      postoperative period. Quantitative variables were represented by the mean, standard deviation
      and the median and interquartile range. The comparison of the distributions of these
      variables between groups was performed using the Mann-Whitney test.
    

Detailed description: 
      The use of FBM, showing beneficial effects on wounds, is well described in the literature.
      The reported findings include anti-inflammatory action, better tissue organization,
      acceleration of angiogenesis, stimulation of leukocyte chemotaxis and reduction of donor area
      size in animals and humans. This is a clinical study with a controlled series of cases, whose
      objectives were: to evaluate the effects of FBM, using LED, on the repair process of the skin
      graft donor area treated with Membracel® and LED versus Membracel ®; to evaluate the
      evolution of the quality of the aspects of the skin donor area, through the score obtained by
      the modified Bates-Jensen Scale; the intensity of the pain reported by the participants; the
      size of the wound area until the 7th postoperative (PO) period and the time for
      re-epithelialization of the donor area. Data collection was performed at the Burn Unit of the
      General Hospital "Dr. José Pangella", from Vila Penteado, São Paulo, Brazil, from December
      2018 to January 2020. The sample consisted of 21 participants and 25 donor areas, 13 of which
      were from the control group, which received only conventional treatment (Membracel®) and 12
      from the experimental group: Membracel® and LED. Data collection instruments were used:
      medical records of the participants, anamnesis and physical examination, the scales: pain
      (Visual Analogic Scale - VAS) and Bates-Jensen to accompany the re-epithelialization process
      and the measurement of donor skin areas in the postoperative period. Participants were
      identified by Arabic numbers, according to the order of arrival at the Hospital. Quantitative
      variables were represented by the mean, standard deviation and the median and interquartile
      range. The comparison of the distributions of these variables between groups was performed
      using the Mann-Whitney test.
    

Intervention name(s): Membracel and LED photobiomodulation; Membracel
Intervention type(s): Radiation; Other
Intervention description(s): Participants were positioned so that the skin graft donor area was accessible. A light-emitting diode (LED) plate was covered with sterile transparent and waterproof film to prevent contamination when in contact with the donor area. The application was in contact, with full coverage of the surgical wound and was irradiated with radiant exposure of 1.53J / cm2 and irradiance of 2.55 mW / cm2 for 10 minutes. It is worth mentioning that the LED plate was applied in direct contact with the skin graft donor area in the immediate postoperative period and on the primary cover used (Membracel®) on the 1st, 3rd, 5th and 7th postoperative days. Coverage remained until spontaneous departure. The researcher and the participants used specific goggles for this procedure.; This group did not receive LED application, remaining with the skin donor area covered by Membracel® and were evaluated under the same conditions.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment