Structural and Functional Imaging and Cognitive Functions in Ovarian Cancer
Condition: Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cancer
MeSH terms: Ovarian Neoplasms; Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms
Study type: Observational

Summary: 
      The purpose of this study is to learn about possible changes in brain anatomy and function,
      and in thinking abilities, such as memory skills, in patients with ovarian cancer who receive
      treatment with chemotherapy. Cancer patients treated with chemotherapy may experience changes
      in thinking abilities, and these may interfere with quality of life. Most of the research to
      date has involved patients with breast cancer, and there are no studies in women with ovarian
      cancer looking at at treatment-related changes in brain anatomy and function.
    


Intervention name(s): Neuroimaging & Neuropsychological Evaluation; Neuroimaging & Neuropsychological Evaluation
Intervention type(s): Other; Other
Intervention description(s): Will undergo structural and functional MRI scans on a Siemens 3T Magnetom Tim Trio research scanner located at the Citigroup Biomedical Imaging Center at Weill Cornell Medical Center (WCMC), which is adjacent to the MSKCC campus. Patients do not undergo routine clinical brain MRIs as part of their assessment and treatment, and the brain MRI scans to be performed in this study are for research purposes only. The MRI scan takes approximately 60 minutes to complete, and about 15 minutes will be required for instructions prior to initiating the study. The MRI studies will be reviewed by a neuroradiologist (Dr. Karimi) to rule out gross structural CNS abnormalities; in case any abnormalities considered to require clinical follow-up are detected, the subject will be contacted and referred for follow-up with their treating physician. Patients will undergo a brief neuropsychological test battery at MSKCC or at Citigroup Biomedical Imaging Center at WCMC; Will undergo structural and functional MRI scans on a Siemens 3T Magnetom Tim Trio research scanner located at the Citigroup Biomedical Imaging Center at Weill Cornell Medical Center (WCMC), which is adjacent to the MSKCC campus. Patients do not undergo routine clinical brain MRIs as part of their assessment and treatment, and the brain MRI scans to be performed in this study are for research purposes only. The MRI scan takes approximately 60 minutes to complete, and about 15 minutes will be required for instructions prior to initiating the study. The MRI studies will be reviewed by a neuroradiologist (Dr. Karimi) to rule out gross structural CNS abnormalities; in case any abnormalities considered to require clinical follow-up are detected, the subject will be contacted and referred for follow-up with their treating physician. Patients will undergo a brief neuropsychological test battery at MSKCC or at Citigroup Biomedical Imaging Center at WCMC
Observational model: Case-Crossover
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients will be identified and recruited by physicians in the Gynecologic Medical Oncology
        Clinic at MSKCC.
      
Keywords: FALLOPIAN TUBE; OVARY; PERITONEUM; Quality of Life; structural MRI; functional MRI; neuropsychological assessment; 12-075