Combined Application of Diode Laser and Different Remineralizing Agents on White Spot Lesions
Condition: White Spot Lesion of Tooth
MeSH terms: Exanthema
Study type: Interventional

Summary: 
      Dental caries is a very common condition, and although it has become less common, it still
      represents a serious public health risk. Caries symptoms range from the earliest molecular
      alterations in the tooth's apatite crystals to an apparent white spot lesion (WSL) or
      eventual cavitation. The white spot lesion looks chalky because minerals are being lost from
      both the surface and the underside of the enamel. A relatively simple and noninvasive caries
      preventive regimen in treating white spot lesions with low-level laser irradiation, either
      alone or with topical ﬂuoride treatment. This treatment results in reduced enamel solubility
      and dissolution.
    

Detailed description: 
      The study was reviewed and approved by the "Ethical research committee "of the Faculty of
      Dental Medicine for Girls; at Al-Azhar University, Cairo, Egypt. This study was conducted on
      90 teeth with white spot lesions (WSLs) detected clinically on the buccal surface of teeth.
      The patients with WSLs were selected randomly from the operative dentistry clinic at the
      Faculty of Dentistry, Girl's Branch, Al-Azhar University

      After examination, the teeth will be assigned into six groups of 15 teeth with white spot
      lesions each according to the remineralizing material used:

        -  The first group (A1B1): The teeth with WSL will be treated with nano-hydroxyapatite
           +fluoride with laser application.

        -  The second group (A1B2): The contralateral teeth will be treated with
           nano-hydroxyapatite +fluoride without laser application.

        -  The third group (A2B1): The teeth with WSL will be treated with nano-hydroxyapatite +
           xylitol with laser application.

        -  The fourth group (A2B2): The contralateral teeth will be treated with nano
           hydroxyapatite+ xylitol without laser application.

        -  The fifth group (A3B1): The teeth with WSL will be treated with 5% sodium fluoride
           varnish with laser application.

        -  The sixth group (A3B2): The contralateral teeth will be treated with 5% sodium fluoride
           without laser application.
    

Intervention name(s): Remin Pro; X Pur Remin; Fluoride varnish
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): A photosensitizing-remineralizing agent mixture was prepared by adding pre-green dye The diode laser was irradiated immediately with 1 W, Exposure time of 10 s, 810 nm, continuous and non-contact mode.; A photosensitizing-remineralizing agent mixture was prepared by adding pre-green dye The diode laser was irradiated immediately with 1 W, Exposure time of 10 s, 810 nm, continuous and non-contact mode.; A photosensitizing-remineralizing agent mixture was prepared by adding pre-green dye The diode laser was irradiated immediately with 1 W, Exposure time of 10 s, 810 nm, continuous and non-contact mode.
Other intervention name(s): Experimental: Remin Pro with laser application; Experimental: Remin pro without laser application; Experimental: Xpur remin with laser application; Experimental: Xpur remin without laser application; Experimental: fluoride varinsh with laser application; Experimental: fluoride varnish without laser application
Intervention MeSH terms: Fluorides; Fluorides, Topical
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The first group (A1B1):15 teeth with WSL were treated with Remin Pro with laser application.
The second group (A1B2): The contralateral 15 teeth were treated with Remin Pro without laser application.
The third group (A2B1): 15 teeth with WSL were treated with X Pur Remin with laser application.
The fourth group (A2B2): The contralateral 15 teeth will be treated with XPur Remin without laser application.
The fifth group (A3B1): 15 teeth with WSL were treated with 5% sodium fluoride varnish with laser application.
The sixth group (A3B2): The contralateral 15 teeth were treated with 5% sodium fluoride without laser application
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: white spot lesion, diode laser, vita easy shade V