Cardiovascular Health Study (CHS) Events Follow-up Study
Condition: Cardiovascular Diseases; Coronary Disease; Cerebrovascular Accident; Diabetes Mellitus; Heart Diseases; Hypertension; Heart Failure, Congestive
MeSH terms: Stroke; Heart Failure; Cardiovascular Diseases; Heart Diseases; Coronary Disease
Study type: Observational

Summary: 
      To support follow-up for the Cardiovascular Health Study (CHS) of coronary heart disease and
      stroke risk factors in adults 65 years or older.
    

Detailed description: 
      BACKGROUND:

      The Cardiovascular Health Study (CHS) is an NHLBI-funded cohort study of risk factors for
      coronary heart disease (CHD) and stroke in adults 65 years or older. In the early 1990s, 5888
      participants underwent examinations that included traditional risk factors and measures of
      sub-clinical disease. During follow-up, many exam components were repeated, and CVD events
      were ascertained. The National Heart, Lung, and Blood Institute has extended CHS contract
      funding (1) to implement a model for a transition from contract-funding to
      investigator-initiated research and (2) to enhance access to CHS data for future papers and
      ancillary studies by CHS and non-CHS colleagues. The Events Follow-up Study will provide a
      foundation for the transition. Current and future papers and ancillary studies using CHS data
      or stored specimens will have additional power and can be conducted more efficiently if a
      service events-core continues to collect and adjudicate CVD events and deaths in a
      standardized fashion.

      DESIGN NARRATIVE:

      Structurally, the primary aims are: (1) to evaluate the incidence rates of and risk factors
      for CVD in older adults, including comparisons between blacks and whites, men and women,
      young old and old; (2) the evaluation of prognosis in inception cohorts of older adults with
      new-onset conditions such as heart failure (HF) and atrial fibrillation; and (3) the
      evaluation of associations between risk-factor change and the incidence of subsequent events.
      Questions of interest include: What are the determinants of the low CHD incidence in women 80
      yrs and older? Do older black women also have a low CHD incidence? What are the determinants
      of CHD, HF, and stroke in adults 80 and older? Are risk factors different between men and
      women, whites and blacks? Do traditional risk factors and measures of sub-clinical disease
      continue to be powerful predictors of CHD, HF and stroke in those 80 and older? In this
      study, the investigators expect to make over 20,000 phone calls to identify 6000
      hospitalizations, 1000 deaths, 3000 events for detailed review, and 1500 new events,
      including 370 CHD, 300 stroke, and 450 HF. These new events represent an increase in the
      number of CVD events of 29% to 35% in whites and an increase of 40% to 49% in blacks. The
      data and specimens collected in CHS represent a major national resource for the study of
      health, aging, and cardiovascular disease in older adults. Additional events follow-up will
      not only provide the opportunity to address the aims of this study, but also enhance the
      power of current and future CHS papers and ancillary studies by CHS and non-CHS colleagues.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        General population