bioihbjkbjnl/mcl2 huggingface dataset:
Reliability of Polish-Version Overactive Bladder Syndrom Scores (OABSS)
Condition: Overactive Bladder; Urinary Incontinence
MeSH terms: Urinary Incontinence; Urinary Bladder, Overactive
Study type: Observational

Summary: 
      The aim of this study was to develop and assess the effectiveness of a Polish version of
      OABSS and to correlate the OABSS with urodynamic study results and UDI-6, IIQ-7
      questionnaires
    

Detailed description: 
      The translation into Polish followed standardized procedures. Women aged between 18-75 years
      were included into the study. All patients were recruited from women attending the Outpatient
      Clinic of the 2nd Gynecology Department of the Medical University in Lublin. SUI was observed
      in 290 cases; OAB in 283 patients and 249 had MUI (confirmed by medical history, and
      urodynamic investigation). All patients completed the Polish version of the OABSS on two
      separate visits: Week 0 and Week 2 and additionally UDI-6, IIQ-7 during visit- Week 2.
    

Intervention name(s): Urodynamic Study; OABSS questionnaire fulfilment; UDI-6 questionnaire fulfilment; IIQ-7 questionnaire fulfilment
Intervention type(s): Diagnostic Test; Diagnostic Test; Diagnostic Test; Diagnostic Test
Intervention description(s): during visit Week 0 patients had urodynamic study; during visit Week 0 and Week 2 patients fulfilled OABSS; during visit Week 2 patients fulfilled UDI-6 questionnaire; during visit Week 2 patients fulfilled IIQ-7 questionnaire
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        All patients were recruited from women attending the Outpatient Clinic of the 2nd
        Gynecology Department of the Medical University in Lublin. SUI was observed in 290 cases;
        OAB in 283 patients and 249 had MUI
Clinical Trial of Dipyridamole in Schizophrenia
Condition: Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder
MeSH terms: Schizophrenia; Psychotic Disorders
Study type: Interventional

Summary: 
      This is a 6-week, randomized, double blind, parallel groups designed, olanzapine-controlled
      trial of oral dipyridamole in symptomatic patients with a (DSM IV) diagnosis of
      schizophrenia, schizoaffective or schizophreniform disorder. This pilot study aims to provide
      preliminary estimates of whether the effect sizes of dipyridamole on positive symptoms,
      negative symptoms, and cognitive deficits differ between schizophrenia patients treated with
      dipyridamole, and schizophrenia patients treated with olanzapine. A total of 30 subjects will
      be recruited locally.
    

Detailed description: 
      Since the demonstrated success of chlorpromazine in treating psychosis in the1950's, the
      pharmacotherapy of schizophrenia has focused mainly on drugs with antidopaminergic actions.
      These drugs have robust effects on reality distortion and disorganization symptom complexes,
      but minimal effect on cognitive impairment, negative symptoms, and functional outcome and
      quality of life measures. Newer generation antipsychotic drugs have a similar profile of
      effects, with some advantages on the course of depression, hostility, suicide, hospital
      readmission rates and motor side effect measures. Side effects such as weight gain, increase
      in cardiovascular stress and diabetes risk are associated with some new generation drugs. A
      new class of drugs is needed to address the inadequate effectiveness and the side-effect
      disadvantages of the currently available pharmacological agents for the treatment of
      schizophrenia. Recently, new treatment strategies using nicotinergic drugs or agonists at the
      glycine modulatory site of the glutamatergic N-methyl-D-aspartate (NMDA) receptor have been
      employed in clinical trials with mixed results. Our proposal focuses on a clinically
      available adenosine agonist, dipyridamole, in a 6-week clinical trial. Published data suggest
      effectiveness of dipyridamole in treating psychosis when added to haloperidol treatment. The
      effectiveness of dipyridamole alone in treating schizophrenia symptoms, although indirectly
      suggested by several lines of evidence, has not been tested.
    

Intervention name(s): Dipyridamole; Olanzapine
Intervention type(s): Drug; Other
Intervention description(s): Week 1- 50 mg bid Week 2- 50 mg am and 100 mg pm Weeks 3-6 100 mg am and 100 mg pm; Week 1- 5 mg BID Week 2- 5 mg am and 10 mg pm Weeks 3-6 10 mg am and 10 mg pm
Intervention MeSH terms: Dipyridamole; Olanzapine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Schizophrenia; Positive symptoms; Negative symptoms; Cognitive deficits
Chinese Translation and Validation of the 8-item Contact Lens Dry Eye Questionnaire (CLDEQ-8)
Condition: Contact Lens; Questionnaire; Contact Lens Discomfort
MeSH terms: Dry Eye Syndromes
Study type: Observational

Summary: 
      This is a cross-cultural adaptation, evaluation and validation study of the 8-item Contact
      Lens Dry Eye Questionnaire (CLDEQ-8) among soft contact lens wearers in China.
    

Detailed description: 
      The aim of this study is to translate the 8-item Contact Lens Dry Eye Questionnaire (CLDEQ-8)
      into Chinese and evaluate its validity, and reliability among soft contact lens wearers in
      China. One hundred and thirty-four Chinese soft contact lens wearers will be included in the
      study. Subjects are required to complete the Chinese version of the 8-item Contact Lens Dry
      Eye Questionnaire (C-CLDEQ-8) on paper before eye examinations. A subgroup of 50 participants
      will be asked to complete C-CLDEQ-8 twice to evaluate the repeatability.
    

Observational model: Case-Only
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        The subjects are residents of Guangzhou, China.
      
Keywords: the 8-item Contact Lens Dry Eye Questionnaire; CLDEQ-8; Contact Lens Discomfort; Questionnaire; Chinese translation and validation
Advance Care Planning in Cognitive Disorders Clinic
Condition: Advance Care Planning
MeSH terms: Cognitive Dysfunction; Cognition Disorders
Study type: Interventional

Summary: 
      Advance care planning among patients with cognitive disorders poses unique challenges to
      clinicians. To improve planning in patients with Alzheimer's disease and other dementias, the
      researchers suggest a routine, standardized approach to these conversations. The main outcome
      measure is the rate of entry of Advance Directive completion in the patient's Electronic
      Health Record (EHR). A control group of similar patients from another provider specializing
      in cognitive disorders will be used to tease out confounding variable effects.
    


Intervention name(s): Advance Care Planning
Intervention type(s): Other
Intervention description(s): The provider will guide advance care planning conversations with patients identified with mild or moderate dementia during their third office visit, approximately three months after the first visit.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Alzheimer's disease; Dementia
Olfactory Stimulation for Very Low Birth Weight Infants
Condition: Very Low Birth Weight Infant
MeSH terms: Body Weight; Birth Weight
Study type: Interventional

Summary: 
      This is a RCT study examining whether odor administration to mothers of very low birth weight
      infants promotes stabilization of vital signs compared with common nursing care. This study
      used breast milk olfactory stimuli familiar and liked by premature infants to understand the
      effects of olfactory stimuli on the physiological indicators of very low birth weight
      infants, the effect on the time of complete enteral nutrition, and the effects on growth and
      development of very low birth weight infants.
    

Detailed description: 
      Fluctuations in vital signs of very low birth weight infants may lead to poor prognosis.
      Research Objectives:

      To evaluate the effect of olfactory stimulation of breast milk on the stability of
      physiological indexes of very low birth weight infants Subjects: Very low birth weight
      infants whose gestational age are less than 32 weeks.
    

Intervention name(s): Olfactory stimulation; Routine nursing care
Intervention type(s): Behavioral; Behavioral
Intervention description(s): 1) For the premature infants who use non-invasive ventilation, place a single layer of gauze soaked in breast milk on the air outlet of the non-invasive ventilator. When inhaling oxygen with a high-flow nasal cannula, the same measure is performed, and the breast milk and sterile gauze soaked in breast milk are replaced every 4 hours. 2) For the premature infants who withdrawn from assisted ventilation, place the breast pad near the infants' nose, and replace the breast milk pad every 4 hours. Acquisition of breast milk pads: use the same brand of breast milk pads; put the breast milk pads used between 00:00 and 07:00 every day (use time > 2 hours) into the same brand of milk storage bags, and use two left and right at the same time. 3) If the premature infants don't have any ventilation support, the breast milk stimulation method is the same as 2). This intervention will continue until premature infants discharge from hospital.; Nursing is performed according to existing nursing practices. Nasal feeding is generally used.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Olfactory stimulation; Heart rate; Oxygen saturation; Respiratory rate
Immunogenicity and Safety of a Booster Dose of Monovalent Glycoprotein-Conjugated (Diptheria Toxin -CRM197) Hib Vaccine in 365-569 Days Old Healthy Infants
Condition: Haemophilus Influenzae Type b (Hib) Infection
Study type: Interventional
Phase: Phase 3

Summary: 
      This study will evaluate the safety and immunogenicity of booster dose of two commercially
      available vaccines used to prevent Haemophilus influenzae type b infections in children
      365-569 days of age
    


Intervention name(s): Haemophilus influenzae type b (Hib) vaccine
Intervention type(s): Biological
Intervention description(s): Comparator study of two commercially available Haemophilus influenzae type b (Hib) vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: Haemophilus influenzae type b (Hib); Vaccine; Anti-PRP antibody
Using Drug Augmentation to Treat Obsessive Compulsive Disorder Patients Who Did Not Respond to Previous Treatment
Condition: Obsessive Compulsive Disorder
MeSH terms: Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Study type: Interventional
Phase: Phase 4

Summary: 
      This will be a controlled, randomized, double-blind and double-dummy study on the treatment
      augmentation strategy for obsessive compulsive disorder patients non-respondent to first line
      pharmacological treatment. The investigators will compare: fluoxetine maintenance at maximum
      dosage for additional 12 weeks; the association of fluoxetine with quetiapine; and the
      association of fluoxetine with clomipramine.
    

Detailed description: 
      Arm 1: SSRI (Fluoxetine 40mg* once a day) + Clomipramine 75mg* once a day.

      Arm 2: SSRI (Fluoxetine 40mg* once a day) + Quetiapine 200mg* once a day.

      Arm 3: SSRI (Fluoxetine 80mg* once a day) + Placebo once a day.

      *or maximum tolerated dose

      We hypothesize that quetiapine and clomipramine will be effective augmentation strategies for
      resistant OCD patients in comparison to placebo.
    

Intervention name(s): Clomipramine (fluoxetine plus clomipramine); Quetiapine (fluoxetine plus quetiapine); Placebo (fluoxetine plus placebo)
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Clomipramine at maximum dosage of 75mg per day plus fluoxetine at maximum dosage of 40mg per day; Quetiapine at maximum tolerated dosage of 200mg per day plus fluoxetine at maximum dosage of 40mg per day; Placebo plus fluoxetine at maximum dosage of 80mg per day
Other intervention name(s): Anafranil; Seroquel; Prozac; Daforin (EMS pharmaceutics)
Intervention MeSH terms: Quetiapine Fumarate; Fluoxetine; Clomipramine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: clomipramine; quetiapine; fluoxetine; placebo; augmentation; obsessive compulsive disorder
Change in Cognitive Function in Obese Patients After Bariatric Surgery - an Observational Study
Condition: Obesity; Bariatric Surgery
Study type: Observational

Summary: 
      Bariatric surgery provides a strong and long-term effect in reducing weight in obese
      subjects. Studies showed that obesity and its comorbidities are associated with a lower
      cognitive performance. The aim of the researchers study is to examine the cognitive
      performance of the patients before and after bariatric surgery.
    


Intervention name(s): Observation
Intervention type(s): Other
Intervention description(s): Observational study to examine changes in cognition following bariatric surgery after one year.
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients from the surgery department of the Charite Universtiy Berlin
Characterization of Low Density Lipoprotein and Mechanism of the Pro Aggregant Effect Through Oxidant Stress and Lipid Exchange
Condition: Diabetes; Metabolic Syndrome
MeSH terms: Metabolic Syndrome
Study type: Observational

Summary: 
      Case control design: lipidomic study in 12 type 2 diabetics with metabolic syndrome, 12
      metabolic syndrome without diabetes, 12 subjects with type 1 diabetes and 12 controls
    


Intervention name(s): Blood sample
Intervention type(s): Procedure
Intervention description(s): Blood sample for lipidomic study
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        group 1: type 2 diabetics with metabolic syndrome group 2: metabolic syndrome without
        diabetes group 3: subjects with type 1 diabetes group 4: controls
      
Keywords: Platelet function; diabetes; metabolic syndrome
Antibacterial Activity of Urea Against Ocular Bacteria
Condition: Urea in Blood; High
MeSH terms: Uremia
Study type: Observational

Summary: 
      Antibacterial properties of urea was tested against 35 isolates from ocular infections.
    

Detailed description: 
      In vitro susceptibility testing was performed with commercially available antibiotic discs,
      homemade urea discs saturated with urea solution at a concentration of 96 mmol. The weight of
      urea in one drop = 0.37 mg, in one ml = 10.34 mg (5 microliter/ disc) discs and combined
      discs (antibiotic discs to which urea solution was added). Combined discs provided better in
      vitro susceptibility results than antibiotics alone.

      Scanning electron micrographs of bacterial isolates incubated overnight with urea solution
      showed marked disruption of bacterial aggregative patterns and irregularities of their cell
      walls.

      Western blotting showed marked reduction in total proteins in bacterial isolates incubated
      overnight with urea solution. These findings may explain the possible mechanisms for
      antibacterial activity of urea solution as a result of protein denaturation.
    

Intervention name(s): Antibacterial Activity
Intervention type(s): Biological
Intervention description(s): Antibacterial Activity of Urea Solution against Ocular Bacterial Isolates
Intervention MeSH terms: Anti-Bacterial Agents
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        individuals with any ocular infection
Dry Eye Under China's Dynamic COVID-zero Strategy
Condition: Dry Eye Symptoms
MeSH terms: Dry Eye Syndromes; Keratoconjunctivitis Sicca
Study type: Observational

Summary: 
      To compare the prevalence of dry eye symptoms and to investigate the association of the risk
      factors with the dry eye symptomatology among university students in the epidemic and
      non-epidemic areas of China under the COVID-zero strategy.
    

Detailed description: 
      As the COVID-19 outbreak at the end of 2019 spread around the world, the World Health
      Organization declared it a public health emergency of international concern on 30th January,
      and a global pandemic on 1st March. In addition to the threat of coronavirus itself,
      anti-epidemic measures such as wearing masks, maintaining social distance, prohibiting group
      gathering, blockade, isolation, curfew, closure, working at home, online learning, etc., have
      also greatly changed people's daily life dynamics. Unlike the previous regional blockade
      (city-wide) suspension of school and work, China has shifted to dynamic prevention and
      control in April 2020, and the basic life and activities in the epidemic area are not
      restricted. This study aims to compare the prevalence of dry eye symptoms and to investigate
      the association of the risk factors with dry eye symptoms among college students in the
      epidemic and non-epidemic areas of China under the dynamic COVID-zero strategy.
    

Observational model: Other
Time perspective: Other
Sampling method: Non-Probability Sample
Study population: 
        The subjects of the study are students from Nanchang University and Henan University.
      
Keywords: dry eye symptoms; anxiety; depression
Study Evaluating The Effects Of Bazedoxifene/Conjugated Estrogens On Endometrial Safety And Postmenopausal Osteoporosis
Condition: Menopause; Osteoporosis
MeSH terms: Osteoporosis
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this research study is to evaluate the safety and effectiveness of this
      investigational drug for the treatment of menopausal symptoms while protecting the
      endometrium (uterine lining) and preventing postmenopausal osteoporosis. Subject
      participation will last approximately 14.5 months.
    


Intervention name(s): bazedoxifene 20 mg/ conjugated estrogens 0.45 mg; bazedoxifene 20 mg/ conjugated estrogens 0.625 mg; bazedoxifene 20 mg; conjugated estrogens 0.45 mg/ medroxyprogesterone acetate 1.5 mg; Placebo
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): One capsule, bazedoxifene 20 mg/conjugated estrogens 0.45 mg (over-encapsulated), once a day for one year.; One capsule, bazedoxifene 20 mg/conjugated estrogens 0.625 mg (over-encapsulated), once a day for one year.; One capsule, bazedoxifene 20 mg (over-encapsulated), once a day for one year.; One capsule, conjugated estrogens 0.45 mg and medroxyprogesterone 1.5 mg (over-encapsulated), once a day for one year.; One capsule, placebo (over-encapsulated), once a day for one year.
Other intervention name(s): Prempro
Intervention MeSH terms: Bazedoxifene; Medroxyprogesterone Acetate; Medroxyprogesterone; Estrogens; Estrogens, Conjugated (USP)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Postmenopausal Women; Bazedoxifene/Conjugated Estrogens
Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation
Condition: Dystocia
MeSH terms: Dystocia
Study type: Interventional
Phase: Phase 4

Summary: 
      Oxytocin is a medication that is often used to strengthen contractions to overcome delayed
      labor progress. The primary aim of this study is to determine whether receiving a higher dose
      of oxytocin lowers the chance of needing a cesarean section when compared to a lower dose of
      oxytocin. Other aims include examining the relationship between dose of oxytocin regimen and
      length of labor, postpartum hemorrhage, intrauterine infection, umbilical cord gas, neonatal
      Apgar score <5 at 5 minutes, and need for neonatal intensive care.
    

Detailed description: 
      This randomized double blind clinical trial of consenting nulliparous women in spontaneous
      labor who require oxytocin for labor augmentation seeks to determine whether use of a high
      dose oxytocin regimen improves obstetric outcomes when compared with a low dose oxytocin
      regimen, in a manner that is safe for both mother and neonate.

      This project will include 1002 women recruited from the obstetrical service at Prentice
      Women's Hospital. Women will be included if they are at least 36 weeks gestation, have a
      singleton pregnancy, and have been diagnosed with spontaneous labor or spontaneous rupture of
      membranes. Women will be exposed to oxytocin for the indication of labor augmentation at the
      discretion of their obstetric provider.

      Women will be randomized with equal probability to intervention group using a fixed
      allocation procedure. To maintain a double blind design, the Prentice Women's Hospital
      pharmacy will carry out the randomization of oxytocin solutions according to the random
      assignment so that neither the women or their care providers nor the investigators will know
      the identity of the intervention assignment. The low-dose oxytocin regimen group will receive
      a starting oxytocin regimen concentration rate of 2 milliunits/minute that can be increased
      at increments of 2 milliunits/minute, as per the discretion of their obstetric provider. The
      high-dose oxytocin regimen group will receive a starting oxytocin regimen concentration rate
      of 6 milliunits/minute that can be increased at increments of 6 milliunits/minute, as per the
      discretion of their obstetric provider.

      Once the women are enrolled, randomized, and in receipt of their assigned interventions,
      further clinical management will be left to the discretion of each woman's obstetric
      provider.

      Prior to discharge from the hospital, baseline demographic and clinical data will be obtained
      via chart review.
    

Intervention name(s): Oxytocin; Sodium Chloride 0.9%
Intervention type(s): Drug; Other
Other intervention name(s): Pitocin; Normal Saline
Intervention MeSH terms: Oxytocin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment