Nutritional Intervention With Yogurt and Flaxseed in Women With Profiles Lipi
Condition: Overweight
MeSH terms: Overweight
Study type: Interventional

Summary: 
      Flax (Linum usitatissimum L.) is an economically important oilseed. Lifestyle and diet are
      the first line interventions to reduce the short-term and long-term cardiovascular risk
      factors. Due to its high content of lignans, α-linolenic acid (LNA) and fiber, flaxseed has a
      beneficial effect on CVD risk factors, components to decrease the risk of cardiovascular
      disease. Objective: To determine the effect of the consumption of flax seed yogurt on the
      women lipid profile values to the limit, users of a pharmacy in Elche and in this way reduce
      the small dyslipidemia. The investigators performed an intervention including 133 women (age=
      25-70 years). Participants were randomly and double-blind distributed into three groups:
      Group 1 (n= 30) consumed flaxseed (FS), yoghurt (Y) and diet (D), Group 2 (n= 32) volunteers
      consumed (Y) + (D) and Group 3 (n=27) consumed only diet. All groups followed a limit
      levels-cholesterol diet. Circulating total cholesterol, HDL-cholesterol, LDL-cholesterol and
      triglycerides and were determined at the beginning and end of a 30-day test. As a result,
      group 1 presented significantly reduced total cholesterol levels. Correlation analysis
      indicated that the intake of (FS) could explain the flaxseed effect of the variation of the
      cholesterol and TG in this group. Altogether, this study concludes that consumption FS exert
      a positive impact in total cholesterol level and TG
    

Detailed description: 
      It is an analytical intervention study, using a random single blind controlled type trial,
      conducted at a pharmacy in Elche on female clients with mild alterations in their lipid
      profile. Since they were patients with a high cardiovascular risk, the investigators aimed to
      determine the effect of the administration of (FS+Y+D), (Y+D) and (D) on various nutritional
      indicators.

      A monitoring of nutritional intervention was carried out for 30 days and blood samples were
      obtained by capillary puncture for total cholesterol levels, triglycerides, glucose. These
      parameters were determined in situ by dry chemistry. A series of anthropometric measures were
      also carried out at the beginning and at the end of the study including weight and height,
      BMI (Body Mass Index), WHR (waist-hip ratio), systolic and diastolic arterial pressure and
      heart rate.

      Statistical analysis was carried out using STATGRAPHICS Centurion XV software (StatPoint
      Technologies, Inc. Warrington, VA, USA); likewise, significance was defined at p ≤ 0.05. Data
      are reported as mean ± standard error of the mean (sem). Intra-group statistical comparisons
      were performed using the following hypothesis tests, both parametric and non-parametric:
      t-test, sign test and signed rank test for paired samples. Inter-group statistical
      comparisons were performed using the one-way analysis of variance and the Kruskal-Wallis
      hypothesis tests. Also, Fisher's least significant difference (LSD) Multiple Range Test and
      Tukey's honestly significant difference (HSD) were used in order to determine which means
      were significantly different from the others. In addition, Generalized Multiple Regression
      was used to statistically analyze the relationships between the variations in the lipid
      profile and the different factors included in the study.
    

Intervention name(s): Raw Flaxseed
Intervention type(s): Dietary Supplement
Intervention description(s): The participants were randomly single blind controlled trial distributed into three groups: (1, n =30), (2, n =32), (3, n =27). For 30 days, participants in group 1 took with 15g flaxseed mixed with yoghurt and diet,(the 15g of flaxseed that was provided in addition to the linen package spoon so all would take far it) group 2 took yoghurt and diet, and group 3 only received the diet.
Other intervention name(s): Raw Flaxseed "Lino Dorado" 8426904171561
Intervention model: Single Group Assignment
Masking: Single (Investigator)
Primary purpose: Prevention
Keywords: commercial flaxseed; cholesterol; lipidic profile; yoghurt; consumption