bioihbjkbjnl/mcl2 huggingface dataset:
Non-Myeloablative Allogeneic Transplant for Myelodysplastic Syndromes and Myeloproliferative Disorders
Condition: Myelodysplastic Syndromes; Myeloproliferative Disorders; Blood and Marrow Transplant (BMT); Myelodysplastic Syndromes (MDS); Myeloproliferative Disorders (MPD)
MeSH terms: Preleukemia; Myelodysplastic Syndromes; Myeloproliferative Disorders; Syndrome
Study type: Interventional

Summary: 
      To improve survival outcomes for patients with MDS and MPD with a nonmyeloablative allogeneic
      hematopoietic cell transplant.
    

Detailed description: 
      Non-Myeloablative Allogeneic Hematopoietic Cell Transplantation for Treatment of
      Myelodysplastic Syndromes and Myeloproliferative Disorders (Except CML)
    

Intervention name(s): nonmyeloablative allogeneic hematopoietic cell transplant
Intervention type(s): Procedure
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Early Intervention, Supervision, Quality and Outcome in ASD
Condition: Autism Spectrum Disorder
MeSH terms: Autistic Disorder; Autism Spectrum Disorder
Study type: Interventional

Summary: 
      The objective of this study is to examine the significance of knowledge of autism spectrum
      disorder (ASD), and early intensive behavioral intervention, as well as trust in EIBI,
      adequate assessment of EIBI quality, and EIBI supervision on EIBI intervention outcome in
      ASD.
    


Intervention name(s): Early Intensive Behavioral Intervention
Intervention type(s): Behavioral
Other intervention name(s): Applied Behavior Analysis
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Pragmatic RCT
Masking: Single (Outcomes Assessor)
Primary purpose: Health Services Research
Keywords: Allegiance; Knowledge; Supervision; Early intervention; Autism
"GameDay Ready": Evaluating a Behavioral Weight Management Program for Black Men Living in the Rural South
Condition: Obesity; Physical Inactivity; Diet, Healthy
Study type: Interventional

Summary: 
      The primary objective of this study is to test the feasibility and acceptability of a 12-week
      behavioral weight management intervention adapted for Black men living in the rural South.
      The intervention is guided by Self-Determination Theory of Motivation, Social Cognitive
      Theory, and Ecological Systems Theory. Key aspects of the intervention include a
      football-themed curriculum, facilitator and peer concordance to the extent possible (ie.,
      similarly aged Black men), an emphasis on male-specific health concerns, group-based
      competition at multiple levels of the intervention (e.g., during in-person physical activity
      sessions and for achieving behavioral goals), a limited educational component, and physical
      activity being a substantial component of meeting sessions.
    


Intervention name(s): GameDay Ready Program
Intervention type(s): Behavioral
Intervention description(s): GameDay Ready is a 12-week, group-based behavioral weight management program in which participants will meet in-person once per week at a publicly accessible walking track. Each weekly session will be led by a trained facilitator and will include a brief educational component, participant updates on progress, group discussions about overcoming barriers, supervised competitive physical activities, and goal setting for the upcoming week. Educational content will be reinforced and social support will be provided during warmup and cool down walks. Participants will be asked to set behavioral goals toward increasing physical activity and improving dietary habits and will be provided resources to self-monitor their activity, dietary intake, and weight.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
2BALANCE: Cognitive-motor Dual-tasking in Persons With Vestibular Disorders
Condition: Vestibular Diseases
MeSH terms: Vestibular Diseases
Study type: Observational

Summary: 
      The overall aim of this study is to elucidate the impact of a vestibular dysfunction on the
      cognitive and motor performance by means of an extensive test protocol, evaluating the
      vestibular, cognitive and motor function using single as well as dual-task paradigms.
    

Detailed description: 
      The test protocol consists of five cognitive tasks, all assessing a different cognitive
      domain: executive function, working memory, processing speed, and visuospatial abilities
      (mental rotation and visuospatial memory). These cognitive tasks will be performed separately
      (in single task condition, while seated), as well as while performing different motor tasks
      (in dual-task condition). These motor tasks will also be performed in single task condition
      (without performing the cognitive tasks).

      The study consists of the establishment of normative age-related data for the single as well
      as dual-task protocol in healthy adults, age ranging from 18 to 65 years old (objective 1).
      Subsequently, the test protocol will be validated in persons with bilateral vestibulopathy
      (objective 2). Finally, a cross-sectional study in persons with unilateral vestibular
      impairment will take place, and the results on the single as well as dual-task components
      will be compared to normative data, as well as to persons with bilateral vestibulopathy
      (objective 3).
    

Intervention name(s): Behavioural
Intervention type(s): Other
Intervention description(s): Assessment of the 2BALANCE protocol: dual-task protocol consisting of a motor task, cognitive task, and motor-cognitive dual-tasks
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Healthy adults were used for establishing normative data of the dual-task protocol
        (convenience sampling).

        Persons with bilateral vestibulopathy, established by vestibular assessment, were used for
        the validation of the study (recruited at the Ghent University Hospital, Antwerp University
        Hospital, and Maastricht University Medical Center).

        Persons with unilateral vestibular impairment, established by vestibular assessment, were
        used for the cross-sectional study (recruited at the Ghent University Hospital).
      
Keywords: Cognition; Motor performance; Dual-task
Pediatric Intubation
Condition: Intubation; Cardiac Arrest
MeSH terms: Heart Arrest
Study type: Interventional

Summary: 
      The aim of the study was to compare time and success rates of TruView PCD video laryngoscope
      and Macintosh laryngoscope for the pediatric emergency intubation with three airway scenarios
      in a standardized manikin model.
    


Intervention name(s): Macintosh Laryngoscope; TruView PCD Video laryngoscope
Intervention type(s): Device; Device
Intervention description(s): Direct-Laryngoscopy; Video-Laryngoscopy
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Effect of Osteopathic Treatment in Pain and Functionality Individuals With Chronic Neck Pain
Condition: Neck Pain
MeSH terms: Neck Pain
Study type: Interventional

Summary: 
      The purpose of this study is to determine whether manipulative osteopathic treatment
      associated exercises improves pain and function in individuals with chronic non-specific neck
      pain
    

Detailed description: 
      The purpose of this study is to determine whether manipulative osteopathic treatment
      associated exercises improves pain and function in individuals with chronic non-specific neck
      pain Design: a randomized single blind placebo controlled trial will be conducted trial.
      Patients (n=40) with non-specific neck pain will be randomized to receive 1) osteopathic
      manipulative treatment and exercise (n=20) or 2) exercise alone (n=20). Participants will
      receive 8 treatments during 4 weeks.

      Clinical outcomes will be obtained at 1 week, four weeks and 24 weeks after end of treatment.

      Methods:

      The primary outcome will be pain measured by 11-point numerical pain rating scale.

      The secondary outcome will be disability measured by the Neck Disability Index, range of
      motion measured by Cervical Range of Motion device, Pressure pain threshold measured by
      electronic algometer.
    

Intervention name(s): Osteopathic manipulative treatment; Exercises
Intervention type(s): Procedure; Procedure
Intervention description(s): Osteopathic manipulative treatment delivered on pragmatic way.; Exercise for stretching and strength for neck muscles
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Caffeic Acid Combining High-dose Dexamethasone in Management of ITP
Condition: Immune Thrombocytopenia
MeSH terms: Thrombocytopenia; Purpura, Thrombocytopenic, Idiopathic
Study type: Interventional
Phase: Phase 4

Summary: 
      The project was undertaking by Qilu Hospital of Shandong University in China. In order to
      report the efficacy and safety of caffeic acid tablets combining with high-dose dexamethasone
      for the treatment of adults with newly-diagnosed primary immune thrombocytopenia (ITP).
    

Detailed description: 
      The investigators are undertaking a multicenter, randomized, double blinded
      placebo-controlled trial of 240 primary ITP adult patients from 8 medical centers in China.
      One part of the participants are randomly selected to receive caffeic acid tablets (given
      orally at a dose of 900mg per day for 3 consecutive months), combining with dexamethasone
      (given orally at a dose of 40 mg per day for 4 days, two cycles with an interval of 10 days);
      the others are selected to receive high-dose of dexamethasone treatment plus placebo.

      Platelet count, bleeding and other symptoms were evaluated before and after treatment.
      Adverse events are also recorded throughout the study. In order to report the efficacy and
      safety of caffeic acid tablets combining with high-dose dexamethasone therapy for the
      treatment of adults with ITP.
    

Intervention name(s): Caffeic acid tablets; Dexamethasone; placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Oral administration of caffeic acid tablets 0.3g three times per day for 3 months; Oral administration of dexamethasone 40 mg for four consecutive days then proceed another cycle 10 days later.; Oral administration of placebo tablets 0.3g three times per day for 3 months
Other intervention name(s): Caffeic acid tablet
Intervention MeSH terms: Dexamethasone; Caffeic acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: ITP; Caffeic Acid; dexamethasone
PCA vs Non-PCA Intravenous Hydromorphone Titration for Severe Cancer Pain
Condition: Cancer Pain
MeSH terms: Cancer Pain
Study type: Interventional
Phase: Phase 3

Summary: 
      A large number of studies have shown that patients feel more satisfied with hydromorphone in
      the pain management. and a systematic review found that hydromorphone may be better suited
      than morphine for titration of acute analgesia. However, current researches on intravenous
      opioid titration for cancer pain such as hydromorphone are relatively insufficient in China.
      Therefore, a prospective, multi-center, randomized controlled study is conducted to assess
      the efficacy and safety of comparing patient-controlled analgesia (PCA) versus non-PCA
      intravenous hydromorphone titration for severe cancer pain.
    

Detailed description: 
      The opioid dose for individual with cancer pain to provide adequate relief of pain with an
      acceptable degree of side effects is variable. Opioid titration is a process to obtain the
      tailored dose. Conventional titration is administered by a clinician or nurse. PCA is that
      patients control cancer pain by self-administration of intravenous opioids using programmable
      pump. The aim of our study is to evaluate the efficacy of PCA titration versus conventional
      titration intravenously for severe cancer pain (10-point numerical rating scale, NRS ≥ 7).
      Injectable Hydromorphone was selected as pharmaceutical analgesics, which works as well as
      morphine and oxycodone and had similar side effects.
    

Intervention name(s): Hydromorphone; PCA pump
Intervention type(s): Drug; Device
Intervention description(s): For opioid-intolerant patients: continuous infusion of hydromorphone 0 mg per hour, and a demand dose of 0.5 mg with a lockout interval of 15 minutes.
For opioid-tolerant patients: basal rate 0 mg per hour, and a demand dose of 10% of the hydromorphone dose equivalent to the total opioid taken in the previous 24 hrs with a lockout interval of 15 minutes.; For opioid-intolerant patients: initial dose 0.5 mg intravenous hydromorphone.
For opioid-tolerant patients: intravenous hydromorphone with a initial dose equivalent to 10%(5-15%) of the total opioid taken in the previous 24 hrs.
Intervention MeSH terms: Hydromorphone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: hydromorphone titration
Multimodal and Unimodal Analgesia in Cholecystectomy
Condition: Compare Unimodal and Multimodal Analgesics
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Many surgical procedures are accompanied by postoperative pain with severity moderate, severe
      or extreme and insufficient postoperative pain control may cause risk of post-surgical
      complications and risk of chronic post-surgical pain The targets of preoperative pain
      management are to relieve patient suffering, reduce length of hospital stay and achieve early
      mobilization after surgery, decreasing opioid consumption and its side effects that are
      constipation, nausea, vomiting, dizziness, respiratory depression which is the most feared
      complication being life-threatening and some less common side effects as sedation
    


Intervention name(s): Pregabalin 150mg; Acetaminophen 1 G Oral Tablet; Celecoxib 400Mg Oral Capsule
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Pregabalin 150mg preoperative in unimodal group Pregabalin 150mg preoperative in multi-modal group; Acetaminophen 1 G Oral Tablet preoperative in multi-modal group; Celecoxib 400Mg Oral Capsule preoperative in multi-modal group
Intervention MeSH terms: Acetaminophen; Celecoxib; Pregabalin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Prothrombotic Factors and Anaesthesia in Prostate Cancer
Condition: Prostatic Cancer; Surgery
MeSH terms: Prostatic Neoplasms
Study type: Interventional

Summary: 
      This study aims to assess if different anesthetic techniques can affect coagulant factors in
      patients with prostate cancer undergoing elective laparoscopic radical prostatectomy (LRP).
    

Detailed description: 
      The utility of anti-thrombotic prophylaxis in cancer patients undergoing laparoscopic radical
      prostatectomy (LRP) is still controversial. Moreover, different anaesthetic techniques could
      modify coagulant factors. Thus, in this study we will be to investigate the variations of
      pro- and anti-coagulant and fibrinolytic factors in two established types of anaesthesia in
      patients with prostate cancer undergoing elective LRP.
    

Intervention name(s): Propofol; remifentanyl; Midazolam; Fentanyl; Sevoflurane
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Other intervention name(s): Diprivan; Ultiva; Fentanest; Sevorane
Intervention MeSH terms: Midazolam; Fentanyl; Remifentanil; Propofol; Sevoflurane
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Prostatectomy; Coagulation Factor; Balanced Anesthesia; Intravenous Anesthesia,
Study to Evaluate the Efficacy of Infliximab Induction Therapy for Patients With Palmoplantar Psoriasis (PPP)(Study P04555)(COMPLETED)
Condition: Psoriasis
MeSH terms: Psoriasis
Study type: Interventional
Phase: Phase 3

Summary: 
      Subjects with psoriasis will receive intravenous infliximab 5 mg/kg given over a 2-hour
      period at Weeks 0, 2, and 6 (induction therapy) to evaluate the efficacy of infliximab at
      Week 18. Subjects who achieved >=75% improvement in Psoriasis Pustulosa Palmoplantaris Area
      and Severity Index (PPPASI) score at Week 8 AND had deterioration of PPPASI score of 50% from
      Week 8 until Week 12 were to receive an additional infusion at Week 12.
    


Intervention name(s): Infliximab
Intervention type(s): Biological
Intervention description(s): Intravenous infliximab 5 mg/kg given over a 2-hour period at Weeks 0, 2, and 6 and possibly at week 12.
Other intervention name(s): SCH 215596; Remicade
Intervention MeSH terms: Infliximab
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Acceptability of Expanded Newborn Screening to Parents in France With or Without Genetics in the First Line
Condition: Expanded Newborn Screening; Parental Acceptability
Study type: Observational

Summary: 
      The recent modifications of the French bioethics law, the therapeutic progress and the
      massive development of advanced genetic techniques (such Next-Generation Sequencing (NGS))
      with a rapid decrease in costs imply to question the extension of Newborn Screening (NBS) to
      new actionable pathologies and the acceptable and relevant methods for its possible
      expansion. International studies are beginning to determine the potential place of NGS in
      NBS. In this perspective, the SeDeN project aims to fully assess the social acceptability of
      these issues by measuring the diversity and consistency of expectations of French health
      professionals, parents and public policy makers.

      The SeDeN-p3 Study focuses on the opinions of parents. It aims to analyze the perception of
      parents in different situations: birth, early childhood, child screened in the framework of
      the national neonatal screening program, etc. The objective of this part is to study the
      understanding and expectations of parents in France regarding the extension of newborn
      screening as well as their preferences regarding its conditions (information, types of
      pathologies, screening methods, etc.).
    


Intervention name(s): Questionnaire; Interview
Intervention type(s): Other; Other
Intervention description(s): Online self-administered questionnaire to quantitatively mesure parental knowledge and expectations on current and expanded newborn screeing and parental acceptability of expanded newborn screening using genetic.; Semi-structured interview to explore parental representations on the extension of newborn screening and - if concerned - to retrace the screening/diagnosis/care management pathway
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Parents or co-parents in France with a sick child or not
Prospective Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Absorption
Condition: Adenoidectomy; Functional Endoscopic Sinus Surgery (FESS); Turbinate Surgery
Study type: Interventional

Summary: 
      This proposed study will assess the hemodynamic effects and measure the systemic absorption
      of topically applied oxymetazoline in patients undergoing functional endoscopic sinus
      surgery, turbinate surgery, or adenoidectomy. These patients will be receiving oxymetazoline
      as standard of care during the surgery.
    


Intervention name(s): Oxymetazoline
Intervention type(s): Drug
Other intervention name(s): Afrin
Intervention MeSH terms: Phenylephrine; Oxymetazoline
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Phase 3 Open-label Extension Trial With Rotigotine in Idiopathic Restless Legs Syndrome Subjects
Condition: Idiopathic Restless Legs Syndrome
MeSH terms: Psychomotor Agitation; Restless Legs Syndrome; Syndrome
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a multicenter, open-label trial to assess safety and tolerability of rotigotine in
      subjects with idiopathic Restless Legs Syndrome (RLS), administered at an optimal dose for up
      to 1 year in subjects who previously participated in SP790 (6-month pivotal trial) or SP794
      (sleep lab trial). Subjects who successfully completed the Maintenance Period and the Taper
      Period of SP790 or SP794 are allowed to enroll in this trial.
    


Intervention name(s): Rotigotine
Intervention type(s): Drug
Intervention MeSH terms: Rotigotine
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Rotigotine; Restless Legs Syndrome
Topical Timolol Gel for the Treatment of Infantile Hemangiomas
Condition: Hemangioma
MeSH terms: Hemangioma; Hemangioma, Capillary; Port-Wine Stain
Study type: Interventional
Phase: Phase 2

Summary: 
      We plan to conduct a study, to see how safe and effective timolol maleate 0.5% gel-forming
      solution is for infantile hemangiomas (IH) and the response of hemangiomas to timolol maleate
      0.5% . Our hypothesis is that timolol will inhibit and possibly reverse growth of appropriate
      infantile hemangiomas.
    

Detailed description: 
      Subjects will be assigned to open label timolol maleate 0.5%. Parents will be instructed to
      place 1 to 2 drops twice a day in the center of the hemangioma. Subjects are expected to use
      the study drug as directed every day for a 4 month period.

      Subjects will be assessed at baseline, 2 weeks, 4 weeks, and every 4 weeks thereafter for a
      total of 5 months. Physical exam, photographs to compare size and color intensity, and a
      scale of improvement will be completed at each visit. Parents will complete a quality of life
      questionnaire regarding their child's hemangioma and its impact on quality of life.

      Subjects who have evidence of worsening would be removed from the study and transferred to
      the clinic for evaluation and treatment.
    

Intervention name(s): timolol maleate 0.5% gel
Intervention type(s): Drug
Intervention description(s): Apply timolol gel 1-2 drops twice a day to lesion
Other intervention name(s): timoptic
Intervention MeSH terms: Timolol
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: hemangioma; birthmark; strawberry hemangioma; timolol