bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Exercise on Cervical Pain Through Educational Videos
Condition: Neck Pain
MeSH terms: Neck Pain
Study type: Interventional

Summary: 
      Due to the increased prevalence of neck pain in studied adolescents and young adults, this
      intervention is carried out, which mainly seeks to compare and verify the effectiveness of
      therapeutic exercise with education, compared to education alone.

      It is also necessary to mention the high levels of stress levels reported in students, which
      can affect the increase in pain and the perception of these at times when stress increases.
      The intervention has been decreed in the weeks before and during the exam period at the
      University of Valencia, to see if the neck pain experienced by students at similar stages of
      their academic life is prevented or reduced.

      It is decided to use education above all to give the participants a tool that allows the
      participants to find out what happens and why it happens when the participants suffer from
      neck pain, as well as an explanation of the pathology and the risk factors and how to avoid
      -the bear. In addition, knowledge about the condition in question can lead to a
      reconceptualization of pain, changing the approach and exposing a different approach, when
      treating the pathology.

      It must be said that in the structure and layout of the informative document, the
      investigators think of an instrument that can serve the participants for the future.

      Another reason for carrying out the study is the few tests on neck pain carried out with new
      technologies. The use of videos, therefore, seeks to facilitate access to the information
      provided, being a useful and practical tool for students, familiar with the use of new
      technologies.

      In addition, the training is intended to be as didactic as possible, the chosen exercises are
      carefully explained and the fact that they are found in videos and not in a practical class,
      favors access to the content in these, for that the participants use the videos at their
      disposal. Finally, treating neck pain with training and education and taking into account the
      stress of students, brings to conventional treatment an interesting perspective of coping,
      focused on the biopsychosocial field.
    


Intervention name(s): Exercise to strengthen neck area.; Information
Intervention type(s): Other; Other
Intervention description(s): An exercise protocol will be carried out through educational videos. There will be a total of four videos which will pose exercises for two weeks each. These exercises will be done twice a week. A reminder will be sent by email on the days that they must be carried out.; Information will be provided on neck pain and how exercise is able to help prevent it.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Ramdomized clinical trial
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Video pills; Exercise; Neck pain
Nasal Continuous Positive Airway Pressure and Airway Patency in Obese Patient
Condition: Obese
MeSH terms: Obesity
Study type: Observational

Summary: 
      The mechanism of Upper airway obstruction (UAO) during anesthesia shares many similarities
      with the upper airway obstruction observed during obstructive sleep apnea (OSA). Nasal
      continuous positive airway pressure (nCPAP) via nasal mask (NM) can maintain the airway
      patent with near 100% success in patients with OSA. Obesity is a major risk factors for
      obstructive sleep apnea and obese patients have a higher prevalence of UAO during anesthesia.
      The investigators hypotheses that nCPAP should eliminate airway obstruction in obese patients
      under anesthesia. The investigators propose to test this hypothesis and determine the
      efficacy of nCPAP on maintaining airway patency in obese patients who require general
      anesthesia compared with CPAP administering face mask.
    

Detailed description: 
      Upper airway obstruction (UAO) is an unpredictable and frequently occurring complication
      during induction of general anesthesia. Since obese patients are more vulnerable to develop
      airway obstruction either during sleep1 or under anesthesia, and the segment of obese
      individuals in the entire population keep growing, difficult airway management under
      anesthesia becomes even more challenging than ever. The most serious event related to
      difficult airway management under anesthesia is "cannot intubate, cannot ventilate".

      The mechanism of UAO during anesthesia has not been well understood. Obese patients are a
      high-risk group for perioperative airway catastrophe and prone to develop progressively
      narrower pharyngeal airways due to an increase of soft tissue volume surrounding the
      pharyngeal airway. The mechanism of UAO during anesthesia shares many similarities with the
      upper airway obstruction observed during obstructive sleep apnea (OSA). Nasal continuous
      positive airway pressure (nCPAP) via nasal mask (NM) can maintain the airway patent with near
      100% success in patients with OSA. Obesity is a major risk factors for obstructive sleep
      apnea and obese patients have a higher prevalence of UAO during anesthesia. Therefore, the
      investigators hypotheses that nCPAP should eliminate airway obstruction in obese patients
      under anesthesia. The investigators propose to test this hypothesis and determine the
      efficacy of nCPAP on maintaining airway patency in obese patients who require general
      anesthesia.
    

Intervention name(s): nasal mask CPAP
Intervention type(s): Device
Intervention description(s): CPAP and ventilation administered via nasal mask
Other intervention name(s): nCPAP
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        adult obese patient undergoing general anesthesia
      
Keywords: Obese patient; nasal CPAP
Moderate-intensity Flow-based Yoga Effects on Cognition and Stress
Condition: Stress; Psychological
Study type: Interventional

Summary: 
      The purpose of this study is to test the efficacy of an 8-week, remotely-delivered,
      flow-based and moderate-intensity yoga intervention (vs. waitlist control), on stress and
      cognitive functioning. Participants will include individuals who are full-time working adults
      between the ages of 18 and 64, and currently experiencing symptoms of psychosocial stress or
      anxiety.
    

Detailed description: 
      Participants who pass a telephone screening, electronically sign our informed consent
      agreement, and complete baseline testing, will be randomized to one of two groups: yoga
      intervention or a waitlist control group. Before and after the 8-week intervention,
      participants will complete psychosocial questionnaires and computerized cognitive testing.
      The remote intervention will be delivered via Google Meet and will be led by a certified yoga
      instructor. During the course of the intervention, participants will be wearing a consumer
      grade accelerometer to track heart rate during yoga sessions and physical activity during the
      8 weeks.
    

Intervention name(s): Yoga
Intervention type(s): Behavioral
Intervention description(s): Moderate-intensity flow-based yoga movements, breathing, and relaxation for 50 minutes, 3 times per week, for 8 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized Controlled Trial
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: sun salutations; longitudinal; remote; cognition
Effect of Probiotic on Depression
Condition: Depression
MeSH terms: Depression; Depressive Disorder
Study type: Interventional
Phase: Phase 1

Summary: 
      Depressive disorder, also known as depression, is a type of mood disorder characterized by
      persistent low mood. The incidence of depression worldwide is about 6%. Growing evidence
      suggested that the gut microbiota plays a key role in the development of depression.
      Probiotics can effectively regulate gut microbiota, and showed potential in alleviating
      depression. This study investigated the effect of formula probiotic (containing Lactobacillus
      paracasei, Bifidobacterium animalis, Bifidobacterium longum, Bifidobacterium bifidum and
      Lactobacillus plantarum) on depression.
    


Intervention name(s): Probiotic; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Patients received the formula probiotic for consecutive 8 weeks ( one sachet per day ).; Patients received the placebo identical to probiotic for consecutive 8 weeks ( one sachet per day ).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Safety and Efficacy of Drug Combinations Against Schistosomiasis
Condition: Parasitic Diseases
MeSH terms: Parasitic Diseases
Study type: Interventional

Summary: 
      This randomised, controlled, double-blinded clinical study investigates the safety and
      efficacy of MBD in combination with PZQ in the treatment of SCH and STH in children aged 1-15
      years of age.
    


Intervention name(s): albendazole + praziquantel; mebendazole + praziquantel
Intervention type(s): Drug; Drug
Intervention description(s): albendazole (400 mg one dose) + praziquantel (40 mg/kg body weight); mebendazole (500 mg one dose) + praziquantel (40 mg/kg body weight)
Intervention MeSH terms: Albendazole; Praziquantel; Mebendazole; Piperazine; Piperazine citrate; DMP 777
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
MAintain the Efficacy and Safety in Treatment of Schizophrenia After Switching to Long-acTing Injectable aRipiprazole From Oral Atypical Antipsychotics
Condition: Schizophrenia; Antipsychotics; Long-Acting Injection; LAI; Aripiprazole
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 4

Summary: 
      Interventional, multicenter, open-label, 20 weeks study

        -  To identify efficacy and safety in switching from oral aripiprazole to Abilify Maintena.

        -  To identify efficacy and safety in switching from oral atypical antipsychotics other
           than aripiprazole to Abilify Maintena
    

Detailed description: 
      We would like to evaluate the efficacy and safety when switching to Abilify Maintena
      according to the approved indication of Abilify Maintena, for subjects who are taking oral
      antipsychotic drugs. It is expected that this will serve as a basis for suggesting a
      successful switching guideline from oral antipsychotics to Abilify Maintena, which can be
      applicable in clinical practice.
    

Intervention name(s): Abilify maintena
Intervention type(s): Drug
Intervention description(s): Switching from oral atypical antipsychotics to long-acting injectable aripiprazole (Abilify maintena)
Other intervention name(s): long-acting injectable aripiprazole
Intervention MeSH terms: Aripiprazole
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: aripiprazole; Long-Acting Injection
A Practical Nomogram Based on Systemic Inflammatory Markers for Predicting Portal Vein Thrombosis in Patients With Liver Cirrhosis
Condition: Systemic Inflammatory Markers; Portal Vein Thrombosis
MeSH terms: Liver Cirrhosis; Thrombosis; Venous Thrombosis
Study type: Observational

Summary: 
      Immunothrombosis has recently been used to describe the responses/mechanisms in thrombosis.
      Systemic inflammatory markers are prognostic markers for a variety of thrombotic conditions;
      however, their potential value in predicting portal vein thrombosis (PVT) is unknown. This
      study aimed to establish an easy-to-use nomogram based on systemic inflammatory markers to
      predict portal vein thrombosis (PVT) in patients with liver cirrhosis.
    

Detailed description: 
      This retrospective study included 478 patients with cirrhosis between January 2013 and
      January 2021. Reputed systemic inflammatory markers (systemic immune-inflammation index
      [SII], neutrophil-to-lymphocyte ratio [NLR], monocyte-to-lymphocyte ratio [MLR], and
      platelet-to-lymphocyte ratio (PLR)) were measured, and the clinical data were recorded. The
      independent risk factors for PVT were determined using univariate analyses and multivariate
      logistic regression analyses, and a nomogram to predict the occurrence of PVT was
      established. The concordance index, receiver operating characteristic curves, and calibration
      plots were used to evaluate the performance of the model.
    

Intervention name(s): clinical laboratory tests, and imaging characteristics
Intervention type(s): Diagnostic Test
Intervention description(s): Data included the demographic status, etiology of the liver disease, clinical laboratory tests, and imaging characteristics. Clinical laboratory tests included D-dimer, activated partial thromboplastin time (APTT), prothrombin time (PT), antithrombin III, international normalized ratio (INR), thrombin time (TT), albumin (Alb), serum creatinine, hemoglobin, platelet count, white blood cell count, neutrophil count, lymphocyte count, monocyte count, model for end-stage liver disease (MELD) score, and Child-Pugh score. Imaging characteristics included splenic vein diameter, splenic vein velocity, portal vein diameter, and portal vein velocity.
Observational model: Case-Control
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        This retrospective study included 478 patients with cirrhosis between January 2013 and
        January 2021 at the Affiliated Hospital of Qingdao University (China).There were 239
        patients with portal vein thrombosis and 239 patients without portal vein thrombosis.
      
Keywords: Portal Vein Thrombosis; systemic inflammatory markers
Slipping Rib Syndrome: A Clinical Entity to Consider in Chest Pain
Condition: Slipping Rib Syndrome
MeSH terms: Tietze's Syndrome; Syndrome; Chest Pain
Study type: Observational

Summary: 
      Slipping rib syndrome consists on false or floating ribs hypermobility, whose can force the
      ribs to come in contact with each other. The authors reported a fourteen case series
      presenting a slipping rib syndrome.
    

Detailed description: 
      Slipping rib syndrome consists on false or floating ribs hypermobility, whose can force the
      ribs to come in contact with each other.

      The authors reported a fourteen case series presenting a slipping rib syndrome. Mean age
      35.00 ± 10.66 years old; 64.29% men.

      The 10th rib level was the most predominant, affecting 64.29% of cases. Dynamic ultrasound
      was the gold standard diagnostic tool. Different conservative treatments were applied in most
      of cases.
    

Intervention name(s): Dynamic ultrasound
Intervention type(s): Diagnostic Test
Intervention description(s): Diagnosis was based on clinic suspicion and positive ultrasonography dynamic maneuvers by reproducing pain and slipping rib exam
Observational model: Case-Only
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Patients affected with Slipping rib syndrome
      
Keywords: Slipping rib syndrome; dynamic ultrasound
Open Label Study of NVP+CBV Treatment in Women Who Have Received sdNVP for the pMTCT of HIV
Condition: Acquired Immunodeficiency Syndrome
MeSH terms: Acquired Immunodeficiency Syndrome; HIV Infections; Immunologic Deficiency Syndromes
Study type: Interventional
Phase: Phase 4

Summary: 
      To determine the response to treatment with NVP, ZDV and 3TC in HIV positive women, who
      previously received NVP for the prevention of mother to child transmission.
    

Detailed description: 
      An open-label, single arm, multicentre study to determine the virologic and immunologic
      responsiveness of women, who previously received a regimen of nevirapine for the prevention
      of MTCT, to a regimen of nevirapine and ZDV+3TC treatment. As well as to evaluate the
      proportion of patients who fail this treatment at 24 and 48 weeks, and to evaluate the
      resistance profile of HIV isolates from patients who fail nevirapine and ZDV+3TC treatment.

      Study Hypothesis:

      When a drug leading to selection of a resistant viral population is withdrawn the original
      wildtype virus, over time, becomes the predominant virus again. However, low frequency (below
      level of detection) of drug resistant viral sub-populations may be retained which could mean
      that the drug resistant variant might reappear rapidly should the same drug be reintroduced
      as part of combination therapy at a later stage.Therefore this study is proposed to evaluate
      whether there is an impact of single dose nevirapine for the prevention of MTCT on the
      subsequent response to a standard HAART regimen that contains nevirapine.

      Comparison(s):

      trial 1100.1090
    

Intervention name(s): Nevirapine; Zidovudine; 3TC
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: Zidovudine; Nevirapine
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
The Influence of Factors on Accuracy of Reported Dietary Intake
Condition: Dietary Assessment; 24-hour Dietary Recall; Dietary Restraint; Social Desirability
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the influence of dietary restraint, social
      desirability, and food type on the accuracy of dietary intake reported during a 24-hour
      recall.
    

Detailed description: 
      The purpose of this study is to investigate the influence of the interaction among dietary
      restraint, social desirability, and food type ("healthy" vs. "unhealthy") on the accuracy of
      reporting consumption of a laboratory meal during a 24-hour dietary recall. The automated
      multiple-pass method (AMPM) of 24-hour dietary recall is considered the gold standard of
      dietary assessment however the potential for error and biases is widely acknowledged with a
      tendency towards underreporting. Underreporting has been linked to many factors including two
      individual characteristics, dietary restraint and social desirability. Both dietary restraint
      and social desirability have been extensively studied however the influence of their
      interaction on reported dietary intake is not fully understood. In addition, a relationship
      to the types of foods (healthy vs. unhealthy) has also been found. For this study, 40
      normal-weight female participants will be recruited at The University of Tennessee using
      flyers inviting volunteers. Participants will be categorized by dietary restraint, high or
      low, and social desirability, high or low, based on questions during the initial screening.
      In a laboratory setting participants will consume a meal of pre-weighed foods, including both
      "healthy" and "unhealthy" foods. The following day, an AMPM 24-hr dietary recall will be
      conducted with the participant over the telephone. Accuracy of the reported dietary intake of
      the laboratory meal will be determined by the equation [(reported intake - measured
      intake)]/measured intake] x100 for amount (weight or volume) and energy (kilocalories) with
      comparisons between groups and within food types using mixed factorial analysis of variance.
    

Intervention name(s): Lunch meal with 24 hour dietary recall
Intervention type(s): Other
Intervention description(s): Each participant will come into the laboratory for a buffet-style lunch meal, where they are instructed to sample each of the foods served. On the next day, a 24 hour dietary recall is performed to test the participants ability to accurately report amounts and types of food consumed. Measures of dietary restraint and social desirability are taken prior to the laboratory meal via phone interview.
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: Dietary Assessment; 24-hour dietary recall; Dietary Restraint; Social Desirability; Portion estimation; Underreporting
Activation of miRNA and Proteins After Acute Experimental Pain. (miRNA: Micro RNA)
Condition: Hypertonic Saline; Isotonic Saline
Study type: Interventional

Summary: 
      In this experiment, the investigators would like to test the following:

        1. Does acute pain induced by hypertonic injection cause changes in plasma miRNA and
           protein expression ?

        2. Can these canges correlate with the development of local hyperalgesia?

        3. How does the plasma miRNA expression change over a duration of 24 hours post pain
           induction ?

        4. Which mRNA targets are potentially affected by acute pain?
    


Intervention name(s): hypertonic saline; Saline injection; Blood sampling
Intervention type(s): Other; Other; Procedure
Intervention description(s): The participant will be given i.d. in 0.1 mL volumes of a hypertonic saline solution; The participant will be given i.d. in 0.1 mL volumes of a saline solution; Whole blood samples (5 mL per each time point, a total of 20 mL per subject) will be collected
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: two groups of subjects: one group will receive hypertonic injection (0.1 ml) and the other group will receive isotonic saline injection (0.1 ml)
Masking: Single (Participant)
Primary purpose: Basic Science
First In Human, Single Escalating Oral Dose Study Of PF-06882961 In Healthy Adult Subjects
Condition: Healthy Subjects
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of
      single oral doses of PF-06882961 in healthy adult subjects. This is the first clinical study
      of PF-06882961.
    


Intervention name(s): PF-06882961; Placebo
Intervention type(s): Drug; Other
Intervention description(s): Single Ascending Doses of PF-06882961 from 3mg to TBD mg.; Placebo Single Dose
Allocation: Randomized
Intervention model: Sequential Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Basic Science