Comparison of Erector Spinae Block and Pecto-Intercostal Facial Block For Enhanced Recovery in Adult Cardiac Surgery
Condition: Cardiac Septal Defects With Coarctation of the Aorta; Mitral Regurgitation
MeSH terms: Mitral Valve Insufficiency; Heart Septal Defects; Aortic Coarctation
Study type: Interventional
Phase: Phase 2

Summary: 
      The current study is designed to compare the perioperative analgesic efficacy of Erector
      spinae plane block (ESPB) and Pecto-intercostal-fascial plane block (PIFB) in adults
      undergoing cardiac surgery via median sternotomy.

      The primary outcome measure will be the analgesic effectiveness of both blocks in median
      sternotomy pain, while the secondary outcome measures will be time to extubation, and length
      of intensive care unit stay.
    

Detailed description: 
      The patients will undergo the same preoperative preparation, intraoperative monitoring, and
      anesthetic technique. Fentanyl (2 μg/kg) will be given with induction of anesthesia, and
      additional increments of fentanyl 2 μg/kg will be administered if mean arterial blood
      pressure or heart rate rise in response to stressful surgical stimuli greater than 20% above
      baseline.

      All surgeries will be performed through median sternotomy, with the same cardiopulmonary
      bypass and myocardial protection technique. At the end of surgery, all anesthetics will be
      discontinued, and patients will be transferred to the ICU where they will be committed to a
      mechanical ventilator.

      the two blocks will be performed using Linear -Array ultrasound transducer probe (SONOSITE
      M-TURBO). After standard chest skin disinfection, the transducer will be covered with a
      sterile sleeve.

      he two blocks will be performed using Linear -Array ultrasound transducer probe (SONOSITE
      M-TURBO). After standard chest skin disinfection, the transducer will be covered with a
      sterile sleeve.

      Ultrasound guided Pecto-intercostal- fascial plane block:

      The block will be performed while the patient in supine position after induction of general
      anesthesia and before skin incision. The probe of the ultrasound will be placed at 2 cm
      lateral to the lateral sternal border at 5th and 6th rib. On the surface plane subcutaneous
      tissue is identified, while Pectoralis major muscle, Intercostal muscles and ribs are seen in
      intermediate plane and lung along with pleura are identified in deep plane. A 22-gauge, 80-mm
      short bevel echogenic needle is used and advanced in in-plane manner, in a caudal-to-cranial
      direction, until the tip of the needle is located in the fascial plane between the pectoralis
      major and internal intercostal muscle, where the local anesthetic will be injected. As the
      drug will be injected, a hydro dissection of the plane is checked for. At this point, color
      doppler ultrasonography will be used to help identify the internal thoracic artery and its
      branches that pass through the plan.

      Ultrasound guided erector spinae plane block:

      The block will be done while the patient is in the sitting position before induction of
      general anesthesia. A high-frequency linear ultrasound transducer will be placed in a
      longitudinal orientation 3 cm lateral to the T6 spinous process corresponding to the T5
      transverse process. Three muscles trapezius (uppermost), rhomboids major (middle), and
      erector spinae (lowermost) will be identified superior to the hyperechoic transverse process.
      Local infiltration with 2% of lignocaine at the site of needle insertion will be done. Using
      in-plane approach a 22 G short bevel needle will be inserted in caudal-cephalad direction,
      until the tip is deep to erector spinae muscle, as evidenced by visible hydro dissection
      below the muscle plane. A 20 ml of 0.25% plain bupivacaine will be injected on each side.
    

Intervention name(s): Ultrasound guided Pecto-intercostal- fascial plane block; Ultrasound guided erector spinae plane block; Bupivacain
Intervention type(s): Procedure; Procedure; Drug
Intervention description(s): The probe of the ultrasound will be placed at 2 cm lateral to the lateral sternal border at 5th and 6th rib. On the surface plane subcutaneous tissue is identified, while Pectoralis major muscle, Intercostal muscles and ribs are seen in intermediate plane and lung along with pleura are identified in deep plane. A 22-gauge, 80-mm short bevel echogenic needle is used and advanced in in-plane manner, in a caudal-to-cranial direction, until the tip of the needle is located in the fascial plane between the pectoralis major and internal intercostal muscle, where the local anesthetic will be injected.; A high-frequency linear ultrasound transducer will be placed in a longitudinal orientation 3 cm lateral to the T6 spinous process corresponding to the T5 transverse process. Three muscles trapezius (uppermost), rhomboids major (middle), and erector spinae (lowermost) will be identified superior to the hyperechoic transverse process.Local infiltration with 2% of lignocaine at the site of needle insertion will be done. Using in-plane approach a 22 G short bevel needle will be inserted in caudal-cephalad direction, until the tip is deep to erector spinae muscle, as evidenced by visible hydro dissection below the muscle plane. A 20 ml of 0.25% plain bupivacaine will be injected on each side.; local anesthetic
Intervention MeSH terms: Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention