Honey Versus Povidone-iodine on Laceration Wounds
Condition: Laceration Face; Wound Heal; Wounds and Injuries; Laceration Arm; Laceration of Leg
MeSH terms: Wounds and Injuries; Lacerations
Study type: Interventional
Phase: Phase 3

Summary: 
      This study evaluates healing time in usage of honey and povidone-iodine over paraffin gauze
      as dressings in the treatment of acute laceration wounds. In Indonesia, especially in rural
      area, where most of the resources is limited and modern dressings are expensive and
      hard-to-find. The investigators tried to find an alternative which was easier to find and
      could act as a substitute of modern wound dressing.

      The hypothesis of this study is honey and povidone-iodine could be a good substitute (or
      equal to) to paraffin gauze on acute laceration wounds.

      Honey is chosen because of its versatility and already well-known to be used as a chronic
      wound dressing. Povidone-iodine was chosen as another alternative because it is still one of
      the most used substance in rural area as a wound dressing, but there is not enough study to
      support the usage of this substance. Paraffin gauze was chosen as a representative of modern
      wound dressing because it fulfilled the standard of wound dressing on acute wound, which is
      non-adherent and also moist.
    

Detailed description: 
      The investigator's team consists of five members, each have their own specific tasks and
      divided by two groups, which are ER group (first time encounter, informed consent, and
      intervention) and polyclinic group (routine wound care). All of the data are primary data.
      Data registry were taken by the team without involving any other party. Any intervention done
      to the participants were also done only by the team(suturing, wound care). Appointment for
      routine wound care was also made by contacting the participant through their cellphone
      numbers which were collected when they come to the ER.

      The data of each of the participant was registered on a form which was pre-made by the
      investigators. It recorded the identity of the patient, history taking, physical examination,
      and also to record more detailed information about our intervention, such as the amount of
      stitches and how many and what kind of resources that have been spent on the participant.

      Every sample will be categorized into 3 randomized groups of intervention; honey,
      povidone-iodine, and paraffin gauze, which will also be categorized by location of their
      wound; face and neck, upper extremity, and lower extremity. Participants on each intervention
      group are distributed evenly using stratified block randomization. Photos of the wound will
      be taken before and after the wound is cleaned, and after the wound has been sutured. Every
      patient will be asked to attend a predetermined schedule for wound care assessment. The wound
      will be evaluated by photos before and after the wound is cleaned, debrided, or have its
      sutures removed. Parameter of evaluation will be duration of wound healing per anatomical
      region, infection, cleanliness of wound, odor, exudate level, pain, itch, and total cost of
      wound care.

      Every paper consists of participants' data that were collected on colored maps based on the
      intervention group (red: povidone-iodine, yellow: honey, blue: paraffin). At the end of the
      study, three of the team's members converted the data to be analyzed using Microsoft Excel
      and SPSS.

      The investigators prepared beforehand the Standard Operational Procedures regarding any
      possibilities of adverse events, such as lidocaine toxicity and honey hypersensitivity and
      were already approved by the hospital's committee.

      The investigators determined the target of the sample size with the total sample of 36
      participants, distributed evenly based on intervention groups and wounds' location using
      stratified block randomization
    

Intervention name(s): Honey; Povidone-iodine; Paraffin gauze
Intervention type(s): Other; Other; Other
Intervention description(s): Substance is given topically after the wound has been sutured; Substance is given topically after the wound has been sutured; Substance is given topically after the wound has been sutured
Other intervention name(s): Madu Nusantara®; OneMed® povidone-iodine 10%; Cuticell® Classic Paraffin Gauze
Intervention MeSH terms: Iodine; Povidone-Iodine; Povidone
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A three-arm parallel assignment where one group receives honey, the second group receives povidone-iodine, and the third group receives paraffin gauze as wound dressing.
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: honey; povidone-iodine; randomized control trial; wound healing