bioihbjkbjnl/mcl2 huggingface dataset:
Examining Parkinson's Disease-Related Retirement: Results of Turkey
Condition: Parkinson Disease
MeSH terms: Parkinson Disease
Study type: Observational

Summary: 
      Although Parkinson Disease's (PD) is usually associated with an older patient population, 5%
      of patients are diagnosed at age 50 and 30% before 65 years of age. This shows that many
      patients with PD have diagnosed during the active study and have long periods of normal
      retirement. After the diagnosis of Parkinson's patients, the duration of leaving of
      employment vary between 0 and 25 years. It was found that patients' full-time working
      capacity decreased by up to 80% and they quitted earlier than the general population. The
      disability associated with PD is thought to be a factor in this situation. Nevertheless, the
      reasons for early retirement are not fully known and more information is needed on the
      specific problems of PD in order for patients to continue their career. The aim of our study
      is to examine the impact of Parkinson's disease on retirement and to contribute to Turkey's
      data. Patients with PD admitted to the Parkinson's disease outpatient clinic, which is the
      biggest clinic of Turkey about neurology, are included in the study. It is planned to meet
      with 75 patients on 31/12/2018 and to reach the end of the data collection phase.
    


Observational model: Case-Only
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Participants were chosen from among retired Parkinson's patients who met the inclusion
        criteria and are applied Istanbul Cerrahpaşa University, has largest movement disorders
        unit of Turkey, between May and December 2018.
      
Keywords: Parkinson Disease, Early Retirement,
Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure
Condition: Chronic Heart Failure
MeSH terms: Heart Failure
Study type: Interventional
Phase: Phase 4

Summary: 
      To evaluate the effects of CO2 inhalation and acetazolamide treatment on exercise-induced
      periodic breathing in patients with chronic stable heart failure.

      Patients will be given CO2 (2%) during a constant workload exercise. Patients will be also
      evaluated by maximal cardiopulmonary exercise test without and with acetazolamide acute and
      chronic treatment.
    


Intervention name(s): acetazolamide
Intervention type(s): Drug
Intervention description(s): i.v. 500 mg of acetazolamide for the acute study and 500 mg of acetazolamide p.o. t.i.d. for two days
Other intervention name(s): Diamox
Intervention MeSH terms: Acetazolamide
Intervention model: Single Group Assignment
Masking: None (Open Label)
Keywords: heart failure,; exercise; periodic breathing,; acetazolamide
Validity and Reliability of Jump Height
Condition: Healthy
Study type: Interventional

Summary: 
      The primary objective is to test intratester and intertester reliability of maximum jump
      height using the sensor Orthelligent Pro.

      The secondary objective is to test the concurrent validity of maximum jump height measured
      with the Orthelligent Pro compared to the gold standard which is the force plate.
    

Detailed description: 
      In everyday physiotherapy practice, there is often no budget for expensive measuring
      instruments. Thus, devices such as a force plate are rarely available. Physiotherapists are
      always looking for inexpensive, practical and portable measuring instruments to evaluate
      therapy outcomes and to make reliable statements about the time for Return to Sport. Maximum
      jump height is a performance-determining factor in various jump-intensive game sports. In
      addition, the jump height serves as an important criterion to decide when an athlete can
      return to his usual sport after an injury. There is a new sensor on the market that measures
      jump height. This sensor is called Orthelligent Pro. It is shown to be a cost-effective and
      feasible measurement method for return to sport in physical therapy practice. So far,
      validity and reliability has never been tested. Therefore, this study aims to test the
      validity and reliability of the Orthelligent Pro for the measurement of maximum jump height.
      Two visits will take place 1-2 weeks apart. At the first visit, participants will complete
      2x3 single-leg countermovement jumps measured by two testers each. At the second visit, three
      jumps are completed measured by the first tester.

      The primary objective is to evaluate the intra-and intertester reliability of maximum jump
      height using Orthelligent Pro. The secondary objective is to test the concurrent validity of
      maximum jump height measured with the Orthelligent Pro compared with the gold standard which
      is the force plate. The primary and secondary endpoints are maximum jump height measured in
      centimeters.
    

Intervention name(s): maximum jump height
Intervention type(s): Diagnostic Test
Intervention description(s): Three single leg countermovement jumps were performed. The maximum jump height is measured with a sensor that is adapted at the subjects'leg and with a force plate.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Double Pick up in Poor Prognosis Women
Condition: Fertility Disorders
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this randomized pilot study is to compare the efficacy of double oocyte
      retrieval vs. conventional antagonist ovarian stimulation protocol in poor prognosis patients
      undergoing IVF/ICSI.
    


Intervention name(s): CFA-double pick up
Intervention type(s): Drug
Intervention description(s): In the study group, 225 IU of rFSH will continue after the first oocyte retrieval (OR). Antagonist administration will be initiated when at least one follicle measuring ≥14 mm will be present in the ultrasound. If one or more follicles ≥17 mm are observed, patients will undergo a second triggering with hCG 5000 IU and a second OR will be performed. In case of patients with no follicular development following 10 additional days of rFSH post-OR
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Care Provider, Investigator)
Primary purpose: Treatment
Short-Delay Cord Clamping Compared to Extended- Delay Cord Clamping in Term Neonates That Require Resuscitation.
Condition: Placental Transfusion
Study type: Interventional

Summary: 
      To determine whether performing extended delayed cord clamping in term neonates that require
      resuscitation improves early transition as compared to short-delayed cord clamping.
    

Detailed description: 
      All subjects will receive delayed cord clamping. One group (short-delay) will receive up to
      one minute of delayed cord clamping and then will be placed either on the mother's abdomen or
      the life-start trolley if extensive resuscitation is required.

      The second group will receive delayed cord clamping for at least 5 minutes and continue until
      the baby has established breathing without additional support or is stable on respiratory
      support (no longer received mask PPV for at least 1-2 minutes, i.e. stable on CPAP or
      intubated). The subject will initially be placed on the mother's abdomen or if the subject
      needs extensive resuscitation they will be moved to the LifeStart bed to receive
      resuscitation measures.

      In either group if the baby is deemed to be unstable (by medical team) to be on the
      life-start trolley the cord will be clamped and the baby will be moved to an adjacent warmer
      for resuscitation.
    

Intervention name(s): Short Delay Cord Clamping; Extended Delay Cord Clamping
Intervention type(s): Procedure; Procedure
Intervention description(s): Delay cord clamping will occur for up to 1 minute. Subject will be placed on mother's abdomen for warmth and stimulation. If the subject is depressed they will be transferred to the radiant warmer for resuscitation.; Extended delay cord clamping will occur for at least 5 minutes and will continue until the subjects begins breathing and/or the cord stops pulsating. Subject will be placed on mother's abdomen for warmth and stimulation. If the subject is depressed they will be transferred to the LifeStart bed for resuscitation adjacent to the mother's bedside.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Delayed cord clamping
A Combined Study in Pediatric Cancer Patients for Dose Ranging and Efficacy/Safety of Plerixafor Plus Standard Regimens for Mobilization Versus Standard Regimens Alone
Condition: Ewing's Sarcoma/Soft Tissue Sarcoma; Neuroblastoma; Brain Tumors
MeSH terms: Sarcoma; Neuroblastoma; Sarcoma, Ewing
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This is a multi-site study with plerixafor in pediatric cancer patients. The study will be
      conducted in 2 stages:

        -  Stage 1 is a dose-escalation study.

        -  Stage 2 is an open-label, randomized, comparative study using the appropriate dosing
           regimen identified in the Stage 1 dose-escalation study.

      All participating patients will receive a standard mobilization regimen as per study site
      practice guidelines (either chemotherapy plus once daily granulocyte-colony stimulating
      factor (G-CSF) or once daily G-CSF alone). The only change to the standard mobilization
      regimen is the addition of plerixafor treatment prior to apheresis for all patients in Stage
      1 (dose escalation), and for those patients randomized to the plerixafor plus standard
      mobilization treatment arm in Stage 2 (randomized, comparative).

      Stage 1 will enroll at least 27 patients. Stage 2 will enroll at least 40 patients.
    


Intervention name(s): plerixafor; plerixafor; plerixafor
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 160 μg/kg subcutaneous (SC) injection; 240 μg/kg subcutaneous (SC) injection; 320 μg/kg subcutaneous (SC) injection
Intervention MeSH terms: Plerixafor
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Comparing Fluoride Varnish and Sealant to Prevent White Spots in Orthodontic Patients
Condition: White Spot Lesion
MeSH terms: Exanthema
Study type: Interventional

Summary: 
      The purpose of the study is o compare the efficacy of CPP-ACP MI Varnish and ProSeal sealant
      in preventing white spot lesion (WSL) formation in orthodontic patients.
    

Detailed description: 
      This prospective randomized clinical trial included 40 orthodontic patients between the ages
      of 12-17 who were randomly allocated to two groups. Group 1 (Sealant Group) received sealant
      on the maxillary anterior canines, lateral incisors, and central incisors, with reapplication
      of the sealant every 3 months. Group 2 (Varnish Group) had MI Varnish applied every 4-6
      weeks, without sealant placed on the maxillary anterior teeth. White spot lesion formation
      was evaluated with standardized digital photographs at two timepoints, T1 (initial
      appointment before bonding), and T2 (12 months later, with brackets removed). The brackets
      were removed in order to facilitate an adequate photographic exam. Photographs were analyzed
      side-by-side at the conclusion of the study with the Enamel Decalcification Index (EDI). The
      location of WSLs were recorded by tooth type and by region. Oral hygiene was evaluated at T1
      and T2.
    

Intervention name(s): Pro Seal Sealant; MI Varnish
Intervention type(s): Device; Device
Intervention description(s): Sealant was reapplied every 3 months; Fluoride varnish was applied every 4-6 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: single center, parallel, randomized clinical trial
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: Oral Hygiene; Orthodontics; White spot lesion; enamel decalcification
Postoperative Analgesic Efficacy of Tetracaine Hydrochloride Gel
Condition: Hysteroscopy
Study type: Interventional

Summary: 
      This study was taken out to assess the postoperative analgesic efficacy of tetracaine
      hydrochloride gel in patients with intrauterine adhesion treating with intrauterine
      balloon.Participates were assigned into two groups by randomly-tetracaine hydrochloride gel
      group and control group.
    

Detailed description: 
      Tetracaine hydrochloride gel contains 1% tetracaine hydrochloride, and a fair dose of
      fungicide, lubricants, remove foam agent, as the long-term local anesthetics. Patients in
      getracaine hydrochloride gel group were covered with a gauze of tetracaine hydrochloride gel
      on the external cervical orifice after insert an utrauterine balloon in the uterine cavity.
      While patients in the control group were covered with a blank gauze after hysteroscopic
      adhesiolysis. Compare the postoperative analgesic scor and patients' analgesic satisfaction
      of the two groups and asess the analgesic efficacy of tetracaine hydrochloride gel.
    

Intervention name(s): Tetracaine hydrochloride gel
Intervention type(s): Drug
Intervention description(s): Tetracaine hydrochloride gel contains 1% tetracaine hydrochloride, and a fair dose of fungicide, lubricants, remove foam agent, as the long-term local anesthetics.
Other intervention name(s): Tetracaine HCL
Intervention MeSH terms: Tetracaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: tetracaine hydrochloride gel; analgesia; intrauterine balloon; hysteroscope operation
Safety and Immunogenicity of Novel Vaccination Schedules With Malaria Vaccines AdCh63 ME-TRAP and MVA ME-TRAP
Condition: Malaria
MeSH terms: Malaria
Study type: Interventional
Phase: Phase 1

Summary: 
      This is an open label phase I study, to assess the safety and immunogenicity of novel
      schedules for vaccination with the candidate malaria vaccines AdCh63 ME-TRAP and MVA ME-TRAP.
      These vaccines have been evaluated previously in a number of clinical trials proved to be
      safe and capable of inducing protective cellular immune response following challenge with the
      parasite. All volunteers recruited will be healthy adults. They will be primed with AdCh63
      ME-TRAP administered intramuscularly and boosted several times with AdCh63 ME-TRAP and MVA
      ME-TRAP according to various schedules.. Safety data will be collected for each of the seven
      regimens. Secondary aims of this study will be to assess the immune responses generated by
      each of these regimes.
    


Intervention name(s): Vaccination Schedule One; Vaccination Schedule Two; Vaccination Schedule Three; Vaccination Schedule Four; Vaccination Schedule Five; Vaccination Schedule Six; Vaccination Schedule Seven
Intervention type(s): Biological; Biological; Biological; Biological; Biological; Biological; Biological
Intervention description(s): Intramuscular injection of 5x10^10 vp of AdCh63 ME-TRAP, intramuscular injection of 2x10^8 pfu of MVA ME-TRAP; Intramuscular injection of 5x10^10 vp of AdCh63 ME-TRAP, intramuscular injection of 2x10^8 pfu of MVA ME-TRAP; Intramuscular injection of 5x10^10 vp of AdCh63 ME-TRAP, intramuscular injection of 2x10^8 pfu of MVA ME-TRAP; Intramuscular injection of 5x10^10 vp of AdCh63 ME-TRAP, intramuscular injection of 2x10^8 pfu of MVA ME-TRAP; Intramuscular injection of 5x10^10 vp of AdCh63 ME-TRAP, intramuscular injection of 2x10^8 pfu of MVA ME-TRAP; Intramuscular injection of 5x10^10 vp of AdCh63 ME-TRAP, intramuscular injection of 2x10^8 pfu of MVA ME-TRAP; AdCh63 ME-TRAP prime D0, AdCh63 ME-TRAP boost W8, AdCh63 ME-TRAP boost W16, MVA ME-TRAP boost W24
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Vaccine; Immune response
Remote Ischemic Conditioning in Patients With Ulcerative Colitis
Condition: Colitis, Ulcerative; Gastrointestinal Diseases; Pathologic Processes; Intestinal Diseases; Inflammatory Bowel Diseases
MeSH terms: Colitis; Intestinal Diseases; Inflammatory Bowel Diseases; Gastrointestinal Diseases; Digestive System Diseases; Colitis, Ulcerative; Ulcer; Pathologic Processes
Study type: Interventional

Summary: 
      Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease (IBD). At the time
      of diagnosis it is not possible to predict the course of the disease, which can range from a
      few flares in a lifetime to uncontrollable disease leading to hospitalization, surgery and
      stoma. There is a continuous need to improve treatment as well as diagnostic and prognostic
      tools.

      This study evaluates the clinical efficacy, tolerability and feasibility of remote ischemic
      conditioning (RIC) in patients with moderate active ulcerative colitis (UC). The
      investigators hypothesize that RIC beyond the well known effect on reperfusion tissue damage
      has a clinically relevant anti-inflammatory effect in UC. RIC constitute a repeated brief and
      non-harmful suppression of blood circulation in a limb. The mechanism of action of RIC is
      likely to involve suppressed inflammation and cell death.

      Our study is a randomized clinical controlled study including 38 patients. Patients will
      receive RIC or sham for 10 consecutive days.

      The effect of RIC on active UC is evaluated by changes patient's symptoms, endoscopy
      findings, and various markers in the blood, faeces and the intestinal wall.
    


Intervention name(s): AutoRIC device
Intervention type(s): Device
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: Ulcerative colitis; Remote ischemic conditioning
Impact of Active Video Game on Cardiorespiratory, Macro and Microcirculation Function of Adolescents With Overweight
Condition: Overweight and Obesity; Cardiovascular Risk Factor; Physical Activity
MeSH terms: Overweight
Study type: Interventional

Summary: 
      This study evaluates the effects of physical exercise through active videogame in the
      microcirculation, macrocirculation, cardiorespiratory function and physical fitness in
      overweight adolescents. For that, they will be randomized into two groups, one being a
      control group and the other intervention group. The randomization will be made by school. The
      intervention group will perform the physical exercise through the active video game, three
      times a week, for 50 minutes, during 8 weeks. Reassessments will be performed before and
      after the intervention to evaluate the outcome variables.
    


Intervention name(s): Active video game
Intervention type(s): Other
Intervention description(s): Among the 20 municipal schools, two will be selected between those with 298 or more students (corresponding to the third quartile of the number of students per school). Next will be selected the school in which the adolescents will be submitted to intervention, and the students from the other school will be control. The intervention will aim to promote physical exercise through active video game XBOX 360 with Kinect. The game selected will be Just Dance, to allow the participation of up to four students at the same time. In addition, a gamification protocol will be performed to increase the adolescents engagement in the exercise.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Intervention with two comparison groups. The control or experimental group will be randomly defined by school
"Experimental" group: will perform physical activity through the use of the active videogame associated with a gamification strategy three times a week for 50 minutes for a period of 8 weeks.
Control group: there will be no intervention proposal, only used for data comparison.
Masking: None (Open Label)
Primary purpose: Other
Keywords: adolescents; obesity; lung function; microcirculation; intima media thickness
Study of Cytrix Use in Pelvic Floor Prolapse Treatment
Condition: Vaginal Vault Prolapse
MeSH terms: Prolapse; Pelvic Organ Prolapse
Study type: Interventional
Phase: Phase 4

Summary: 
      To evaluate safety and effectiveness of using the fetal bovine dermis (Cytrix) in the
      treatment of pelvic organ prolapse.
    


Intervention name(s): Cytrix; Other treatments for pelvic organ prolapse
Intervention type(s): Device; Other
Intervention description(s): Treatments for pelvic organ prolapse using other products (standard of care for treatment of pelvic organ prolapse)
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Partners in Wellness: Evaluation of a Pay for Performance Program for High-Utilizers of Mental Health Services
Condition: Psychotic Disorders; Bipolar Disorder; Substance Use Disorders
MeSH terms: Substance-Related Disorders; Bipolar Disorder; Psychotic Disorders
Study type: Interventional

Summary: 
      Healthcare systems in the United States (U.S.) have long faced the considerable challenge of
      managing budgetary pressures while at the same time helping people with serious mental
      illness and/or addiction. One potential way to address this challenge is to offer
      community-based services for individuals who are high-utilizers of expensive emergency and
      inpatient psychiatric services. Due to the decentralized nature of California governance,
      responsibility for mental health services falls primarily to the individual counties. The
      County of Santa Clara, CA invests significantly in community-based services as well as
      24-hour care settings. This County adopted an innovative Pay for Performance (PFP) model and
      contracted with a new care provider to better meet the needs of this patient population and,
      in turn, reduce demand on the County's 24-hour psychiatric services. Whether this innovative
      contracting framework will help individuals who thus far have not responded well to mental
      health services is unknown. The purpose of this study was to determine whether the quality of
      care for these high-need patients was improved and at a sustainable cost. To this end, a
      randomized clinical trial (RCT) was conducted to determine whether this innovative quality
      improvement initiative, referred to as "Partners in Wellness", was successful at reducing the
      total cost of 24-hour psychiatric care used by enrollees compared to individuals who
      concurrently received services from the county. Individuals were randomly assigned to the
      Usual Care (UC) or Pay-For-Performance (PFP) conditions. The primary outcome of this
      evaluation was reduction in the total cost of 24-hour psychiatric services in the target
      population.

      the primary outcome of this evaluation was reduction in the total cost of 24-hour psychiatric
      services in the target population.
    


Intervention name(s): Pay For Performance (PFP); Usual Care (UC)
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Wraparound mental health, psychosocial, and addiction treatment services provided by contractor under an schedule of rewards or penalties that was agreed to with Santa Clara County.; Outpatient and inpatient mental health and psychosocial services delivered by Santa Clara County services and systems.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment