Analysis of Postoperative Ocular Surface Changes and Intervention Effect After PPV in MGD Dry Eye Patients
Condition: Meibomian Gland Dysfunction of Unspecified Eye, Unspecified Eyelid
MeSH terms: Dry Eye Syndromes; Meibomian Gland Dysfunction
Study type: Interventional
Phase: Phase 4

Summary: 
      AIM: To observe ocular surface changes after phacovitrectomy in patients with mild to
      moderate meibomian gland dysfunction (MGD)-type dry eye and track clinical treatment response
      using a Keratograph 5M and a LipiView interferometer.

      METHODS: Forty cases were randomized into control group A and treatment group B; the latter
      received meibomian gland treatment 3 days before phacovitrectomy and sodium hyaluronate
      before and after surgery. The average non-invasive tear film break-up time (NITBUTav), first
      non-invasive tear film break-up time (NITBUTf), non-invasive measured tear meniscus height
      (NTMH), meibomian gland loss (MGL), lipid layer thickness (LLT) and partial blink rate (PBR)
      were measured preoperatively and 1 week, 1 month and 3 months postoperatively.
    


Intervention name(s): Routine preoperative and postoperative anti-infection therapy; artificial tear therapy; Cleaning, hot compresses and massage of the meibomian gland
Intervention type(s): Drug; Drug; Procedure
Intervention description(s): received gatifloxacin eye drops (Otsuka Pharmaceutical Co., Ltd.) 4 times daily and gatifloxacin eye ointment once every night (Shenyang Xing Qi Pharmaceutical Co., Ltd) for 3 days before surgery. Postoperatively, gatifloxacin eye drops were administered 4 times daily, 0.1% fluorometholone (San Tian Pharmaceutical Co., Ltd., China) was administered 4 times daily, and pranoprofen (Qian Su Pharmaceutical Co., Ltd., Japan) was administered 4 times daily. The doses of the above three drugs were reduced each week. The compound tropicamide was administered once a day (Shentian Pharmaceutical Co., Ltd., China). All of the above procedures were stopped 1 month after surgery.; given 0.1% sodium hyaluronate eye drops 4 times daily for 3 days before surgery (Jiang Xi, Zhen Shiming Pharmaceutical Co., Ltd.) and 3 months after surgery.; Group B used a steam eye mask (Your Ga Run Fang, Shang Hai Run Mu Industrial Co., Ltd.) for 20 minutes 3 days before surgery. Sterile cotton swabs were used to apply physiological saline to the eyelid for local cleaning, and the secretions and phosphorus debris on the surface of the eyelid margin were removed to fully expose the meibomian gland. Meibomian gland tweezers were used to squeeze from the root of the gland toward the opening to expel the secretions; each gland was expressed twice. After the operation, an appropriate amount of gatifloxacin cream (Shen Yang Xing Qi Pharmaceutical Co., Ltd.) was applied to the conjunctival sac to prevent infection. Hot towels (40°C) were applied to the eyes for 10 minutes every morning and evening for 3 days before the operation.
Intervention MeSH terms: Lubricant Eye Drops
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Meibomian gland dysfunction; Dry eye; Non-invasive ocular surface analyser; Pars plana vitrectomy; ,Meibomian gland massage