bioihbjkbjnl/mcl2 huggingface dataset:
The Effect of Kinesio Taping on q Angle and Pes Planus in Children With Cerebral Palsy
Condition: Cerebral Palsy; Pes Planus
MeSH terms: Flatfoot; Paralysis; Cerebral Palsy
Study type: Interventional

Summary: 
      The aim of our study is to examine the effect of using kinesiology tape and using it for 8
      weeks on Q angle and pes planus on children with cerebral palsy.
    

Detailed description: 
      At the beginning of the study, the pes planus level of the children will be determined. Then
      randomization will be made and divided into 3 groups with equal number of participants. The
      groups will be called control, experiment, and placebo. Only physiotherapy will be applied to
      the control group, kinesio taping and physiotherapy to the experimental group, and damask
      taping and physiotherapy to the placebo group. The study will be followed for 8 weeks, and
      pre- and post-intervention data were statistically analyzed and compared.
    

Intervention name(s): exercise; exercise and taping; placebo
Intervention type(s): Other; Other; Other
Intervention description(s): Exercise protocol:
Progressive Resistance Exercise Training Bridge exercise sit-up exercise functional walking exercise Stretching; When applying kinesiology taping to the gluteus medius, first of all, for its anterior fiber, the tape portion will be attached lateral to the Spina iliaca anterior superior by giving a slight slope downwards from the crista iliaca with 50-75% tension. For the posterior fiber; Starting from the trochanter major, 50-75% tension will be applied along the muscle fiber.; In the placebo tape application, the kinesiological tappings will be adhered horizontally without tension along the long line of the Tensor facie late muscle. The application to the ankle will be attached horizontally, without tension, slightly above the lateral malleolus.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomization will be made and divided into 3 groups with equal number of participants. The groups will be called control, experiment, and placebo. Only physiotherapy will be applied to the control group, kinesio taping and physiotherapy to the experimental group, and damask taping and physiotherapy to the placebo group.
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Cerebral palsy; Kinesio tape; Pes Planus; Q angle; Exercise
Impact of Family History and Decision Support on High-risk Cancer Screening
Condition: Colorectal Cancer
MeSH terms: Colorectal Neoplasms
Study type: Interventional

Summary: 
      Family health history can help identify patients at higher than average risk for disease.
      There is no standardized system for collecting and updating family health history, using this
      information to determine a patient's disease risk level, and providing screening
      recommendations to patients and providers. Patients will enter their family health history
      into MeTree, a family history software program. The program will produce screening
      recommendations tailored to the patient's family health history. The investigators will
      examine whether this process increases physician referrals for, and patient uptake of,
      guideline-recommended screening for colorectal cancer.
    

Detailed description: 
      Eligible patients are aged 40-65 years, enrolled in primary care, do not have a personal
      history of colorectal cancer, and have some knowledge of family health history. In Aim 1, a
      retrospective chart review will be conducted to determine the baseline rate of documenting
      family health history of colorectal cancer in the medical record for patients enrolled in the
      Aim 2 randomized trial. In Aim 2, consented patients will be randomized to provide
      patient-entered family health history and receive patient and provider decision support at
      enrollment or 12 months later (wait-list control). The primary outcome is risk-appropriate
      CRC screening/surveillance referral for patients 12 months post-enrollment. Secondary
      outcomes include patient uptake of recommendations and referral for genetic consultation 12
      months post-enrollment. In Aim 3, qualitative interviews will be conducted with physicians
      and clinic leaders; data will be analyzed using conventional content analysis. In Aim 4, data
      will be obtained from the administrative databases and patient medical records to conduct a
      budget impact analysis.
    

Intervention name(s): Family health history platform (MeTree)
Intervention type(s): Behavioral
Intervention description(s): Participants will enter their family health history information into a family health history platform, patients and providers will receive a decision support document and pedigree
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: colorectal cancer; early detection of cancer
Buying Time: Improving Sleep to Promote Cognitive Function in Older Adults
Condition: Sleep; Aging
Study type: Interventional

Summary: 
      The purpose of this study is to investigate whether a comprehensive group education combined
      with a lifestyle "activation" program that includes (a) sleep hygiene course, (b) physical
      activity promotion, and (c) bright light therapy, can improve both sleep quality and
      cognitive function among 96 community-dwelling older adults.
    

Detailed description: 
      96 community-dwelling older adults with sleep complaints will be randomized into either a
      6-month life style and sleep activation intervention program or a waitlist control group
      (participants in this group will be offered an abbreviated version of the program upon
      completion of the 6 month study). There are 3 measurement sessions to measure cognition,
      sleep, and physical activity at the onset of the study, the midway (3 month) point, and
      completion (at 6 months).
    

Intervention name(s): Life Style and Sleep Intervention
Intervention type(s): Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Muscle Synergies During Gait in Children With Cerebral Palsy Undergoing Robot-assisted Gait Therapy
Condition: Cerebral Palsy
MeSH terms: Paralysis; Cerebral Palsy
Study type: Interventional

Summary: 
      This is a single-arm longitudinal study for children with cerebral palsy with gait
      impairments that involves robot-assisted gait training (RGT) and includes pre and post-data
      collection visits. The study aims to evaluate changes in muscle synergies in children with
      Cerebral Palsy (CP) in response to RGT. Additionally, the study aims to investigate the
      relationship between muscle synergies and the clinical outcomes of RGT.
    

Detailed description: 
      Participants will be assessed 2 times - before and after training with the robot. All the
      testing and training sessions will be carried out at Spaulding Rehabilitation Hospital and
      will include:

      Clinical tests:

        -  A test to evaluate gross motor function

        -  A test to assess walking speed

        -  A test to assess endurance

      Muscle activity tests:

        -  A test to derive detailed measures of how well participant walk using a camera-based
           motion capture system.

        -  Special sensors (called electromyographic - EMG - sensors) will be used to determine
           when and how muscles are recruited to generate movements.

      Training with the Robot:

      Study participants will undergo 18 sessions of robot-assisted gait training for 18 time The
      training sessions will be carried out by trained study staff. The robot will assist study
      participants to walk. Each training session will last about 1 hour.
    

Intervention name(s): Robot-Assisted Gait Training
Intervention type(s): Device
Intervention description(s): Training will be performed using the LokomatPro. The Lokomat consists of a driven (motorized) gait orthosis (DGO) and an advanced body weight support system, combined with a treadmill. It uses computer-controlled motors which are integrated in the gait orthosis at each hip and knee joint. The exoskeleton is secured to a person's lower limbs using straps.
Training protocol: Each training session will include 30 minutes of gait training. Training will take over a period of about 6-7 weeks. Sessions will last approximately 60 minutes.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Cerebral Palsy; Robotics; Gait rehabilitation
Effect of High Frequency Chest Wall Oscillation Vests on Spirometry Measurements
Condition: Cystic Fibrosis; Bronchiectasis
MeSH terms: Cystic Fibrosis; Bronchiectasis
Study type: Interventional

Summary: 
      The impact of high-frequency chest wall oscillation therapy on spirometry values (Forced
      Expiratory Volume, Forced Vital Capacity, Peak Expiratory Flow, Forced Expiratory Flow and
      Tidal Volume is investigated during use of several products and comparing to baseline values.
    

Detailed description: 
      The study will be broken into three (3) arms:

        -  AffloVest® & The Vest®

        -  AffloVest® & inCourage®

        -  AffloVest® & SmartVest® Subjects will be randomly assigned to an arm. Within each arm,
           the order of products will be also randomized.

      Baseline spirometry (Forced Expiratory Volume (FEV1), Forced Vital Capacity (FVC), Peak
      Expiratory Flow (PEF), Forced Expiratory Flow (FEF25-75%) and Tidal Volume (TV)) will be
      taken at the beginning, middle and end of each series of measurements with each subject,
      without any device on the subject.

      A product (AffloVest or Compressor-based vest) will be placed onto subject and turned ON to
      the highest frequency and intensity settings. Then the subject will be given a certain period
      of time to adjust and spirometry measurements will then be repeated, then The product will be
      removed and the subject will be allowed a recovery period, then the other product will be
      placed on the subject, turned ON and spirometry measurements will repeated.
    

Intervention name(s): International Biophysics AffloVest; Hill-Rom The Vest; Respirtech inCourage; Electromed SmartVest
Intervention type(s): Device; Device; Device; Device
Intervention description(s): High-frequency chest wall oscillation vest; High-frequency chest wall oscillation vest; High-frequency chest wall oscillation vest; High-frequency chest wall oscillation vest
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Bioequivalence Study of Sorafenib Tablet and Nexavar
Condition: Fasting
Study type: Interventional
Phase: Phase 1

Summary: 
      Randomized, open-label, 3-way reference replicated crossover bioequivalence study of
      sorafenib 200 mg tablet and nexavar (reference) following a 200 mg dose in healthy subjects
      under fasting conditions.
    

Detailed description: 
      This will be a single centre, bioequivalence, open-label, randomized, single-dose, 3-period,
      3-sequence, reference replicated, crossover study. 36 healthy adult males or non-childbearing
      potential females, ≥18 and ≤65 years of age, smoker and/or non-smoker.
    

Intervention name(s): Nexavar; Sorafenib
Intervention type(s): Drug; Drug
Intervention description(s): Single oral dose (1 x 200 mg) sorafenib or Nexavar in each period. No food were allowed from at least 10 hours before dosing until at least 4 hours after dosing.
Except for water given with study medication, no fluids were allowed from 1 hour before dosing until 1 hour post-dose.; Single oral dose (1 x 200 mg) sorafenib or Nexavar in each period. No food were allowed from at least 10 hours before dosing until at least 4 hours after dosing.
Except for water given with study medication, no fluids were allowed from 1 hour before dosing until 1 hour post-dose.
Other intervention name(s): sarafenib
Intervention MeSH terms: Sorafenib
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: bioequivalence
A Study to Assess the Long- Term Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder
Condition: Major Depressive Disorder; MDD; Depression
MeSH terms: Depression; Depressive Disorder; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to determine if TC-5214 or placebo (a tablet that looks like
      medicine tablet or capsule, but contains no active medicine) is safe and effective when taken
      for 52 weeks with another antidepressant medicine.
    


Intervention name(s): TC-5214; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Tablet, oral, twice daily for 52 weeks; Tablet, oral, twice daily for 52 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Major Depressive Disorder; MDD; Depression; Safety; add-on therapy
Dose-response Evaluation of the Cellavita HD Product in Patients With Huntington's Disease
Condition: Huntington Disease
MeSH terms: Huntington Disease
Study type: Interventional
Phase: Phase 2

Summary: 
      Cellavita HD is a stem-cell therapy for Huntington's Disease. This is a prospective, phase
      II, single-center, randomized (2:2:1), triple-blind, placebo controlled study, with two test
      doses of Cellavita HD product.
    

Detailed description: 
      This is a phase II dose-response study in which participants with HD will receive three
      intravenous injections of the investigational product or placebo (one every month for three
      months) a total of three cycles. The subjects will be randomized in 2: 2: 1 ratio for the
      groups G1: lower dose (1x10^6 cells/weight range), G2: higher dose (2x10^6 cells/weight
      range) or G3: placebo. To identify the dose of the product that will provide the best
      clinical response, motor assessment will be performed with UHDRS scale and improvement will
      be evaluated by correlating before and after treatment scores. Additionally, also will be
      performed the combined score through the cUHDRS. Secondary evidences of efficacy will be
      evaluated through the data of functional state, total functional capacity, functional
      independence, psychiatric symptoms and cognition from UHDRS scale. Additionally, related data
      to clinical worsening, change of Body Mass Index (BMI), risk of suicide attempt and
      neurological image improvement will be evaluated. Safety evaluation will included the
      incidence and classification of the adverse events experienced by the subjects during the
      study.
    

Intervention name(s): Cellavita HD lower dose; Cellavita HD higher dose; Placebo
Intervention type(s): Biological; Biological; Other
Intervention description(s): The participants will receive a total of 9 intravenous administrations of 1x10^6 cells/weight range divided into three administrations per cycle. Each administration will occur every 30 days and cycles every 120 days (total of 3 cycles).; The participants will receive a total of 9 intravenous administrations of 2x10^6 cells/weight range divided into three administrations per cycle. Each administration will occur every 30 days and cycles every 120 days (total of 3 cycles).; The participants will receive a total of 9 intravenous administrations of placebo divided into three administrations per cycle. Each administration will occur every 30 days and cycles every 120 days (total of 3 cycles).
Other intervention name(s): cellular therapy, mesenchymal stem cells; cellular therapy, mesenchymal stem cells; physiological solution without cells
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Huntington disease; Stem cell therapy; Dental pulp stem cell
Radioembolization With Yittrium-90 for Intermediate and Advanced Hepatocellular Carcinoma
Condition: Hepatocellular Carcinoma; Radioembolization
MeSH terms: Carcinoma; Carcinoma, Hepatocellular
Study type: Interventional

Summary: 
      Hepatocellular carcinoma (HCC) is the fifth most-common cancer worldwide and the second
      most-common cause of cancer mortality. Liver resection is the first-line curative treatment
      for huge HCC. The 5-year overall survival (OS) rates after hepatic resection were range from
      25% to 45%. Transarterial chemoembolization (TACE) is the major treatment option for the
      unresectable primary or secondary liver malignancies. Yittrium-90 (Y-90) is a pure
      beta-emitter, without any toxic effect or immune rejection. There are ample data that support
      the use of Y-90 microspheres for primary and metastatic liver tumors. The aim of our study
      was to compare the clinical outcome of radioembolization with Y-90 and TACE and provide a new
      strategy for the treatment of intermediate and advanced hepatocellular carcinoma with portal
      vein thrombus by conduting a randomized trial.
    


Intervention name(s): TACE; radioembolization with Y-90
Intervention type(s): Procedure; Procedure
Intervention description(s): radioembolization with Y-90
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Yittrium-90; Hepatocellular Carcinoma
Epidural Steroid Following Discectomy for Herniated Disc Reduces Morbidity
Condition: Disc Disease
Study type: Interventional

Summary: 
      Focus of this study is evaluation of the outcome, neurologic impairment and safety of
      epidural steroide following lumbar discectomy for herniated disc disease.
    

Detailed description: 
      Methylprednisolone might enhance recovery after discectomy for herniated disc disease without
      apparent side effect.

      Convalescence after discectomy for herniated disc disease is dependent on pain and the
      inflammatory response. In arthroscopic and abdominal surgery steroids reduce the inflammatory
      response and enhance recovery.

      200 patients with herniated disc disease are randomly allocated to receive epidural
      methylprednisolone 40 mg or none.
    

Intervention name(s): Methylprednisolone
Intervention type(s): Drug
Intervention description(s): Epidural methylprednisolone 40 mg or none
Intervention MeSH terms: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: discectomy; methylprednisolone; randomized control trial
Engaging Immigrants in Preventive Parenting Interventions
Condition: Health Behavior; Parenting; Social Acceptance
Study type: Interventional

Summary: 
      The objective of this community-based randomized controlled trial is to evaluate the outcomes
      of a theory-based parent engagement intervention (i.e., culturally-tailored video) aimed at
      promoting the participation of Filipino parents and grandparents in an evidence-based
      preventive parenting intervention.
    

Detailed description: 
      Data will be obtained using pre and post surveys with self-report instruments and enrollment
      logs. It is hypothesized that 1) Parents and grandparents in the Intervention Arm will
      demonstrate greater behavioral outcomes (intention to enroll, actual enrollment, and
      participation in parenting intervention sessions) than those in the Control Arm. 2) Parents
      and grandparents in the Intervention Arm will show greater improvements from baseline in
      parent determinants (knowledge, beliefs, attitudes, benefits, and barriers) compared to the
      Control Arm. 3) Parents' intention to enroll, and actual enrollment in IY will be predicted
      by the study arm and parent determinants. This study is expected to have an important impact
      on the uptake of evidence-based parenting interventions among hard-to-reach populations and
      holds the promise of eliminating disparities in behavioral health outcomes in this
      understudied and growing minority population.
    

Intervention name(s): Video Documentary entitled, "Para Sa Kinabukasan ng Mga Anak (For Our Children's Future)"; Usual Care Video that is publicly available
Intervention type(s): Other; Other
Other intervention name(s): Intervention Arm; Control Arm
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: Filipino
OT Intervention Via Telehealth for Children With ASD and ADHD
Condition: Autism Spectrum Disorder; Attention Deficit Hyperactivity Disorder
MeSH terms: Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder
Study type: Interventional

Summary: 
      This study aims to measure the impact of a telehealth-based model of occupational therapy
      (OT) treatment on clinical outcomes for children with autism spectrum disorder (ASD) and/or
      attention deficit hyperactivity disorder (ADHD). Half of the participants will receive
      clinic-based, in-person services and half of the participants will receive video-based,
      Telehealth services.
    

Detailed description: 
      Children with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder
      (ADHD) often receive occupational therapy (OT), which traditionally takes place in a clinical
      setting. This setting may present barriers and distractors that make it hard for children to
      achieve their OT goals. Telehealth-based sessions provide an alternative, allowing the
      therapist to be virtually present within the home.Once enrolled, children will randomly be
      assigned to be in one of two groups: (1) Standard, in which children will receive
      clinic-based services as per standard of care OR (2) Telehealth, in which children will
      receive in-home services on a video-based platform on a timeline identical to what they would
      receive if they were in the Standard group. Children in both groups will participate for the
      duration of the episode of care, estimated to last 10-12 weeks. Assessments will be completed
      at initial evaluation, discharge, and three months following discharge.
    

Intervention name(s): Occupational Therapy via Telehealth; Standard of Care Occupational Therapy
Intervention type(s): Other; Other
Intervention description(s): The caregiver will be with the participant in their home environment receiving occupational therapy via Telehealth (video-calling) with the occupational therapist.; The caregiver and participant will be in the clinic receiving occupational therapy in-person with the occupational therapist.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Participants are randomized to the Telehealth arm of the study or the Standard Care arm of the study.
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment