Risk Stratification of Heart Failure in Cardiomyopathies.
Condition: Cardiomyopathy With Unknown Etiology
MeSH terms: Heart Failure; Cardiomyopathies
Study type: Interventional
Phase: Phase 1

Summary: 
      The investigators aimed to use CMR technique in helping diagnose the etiology of unknown
      cardiomyopathy. Try to make a risk stratification of susceptible heart failure based on the
      extent of myocardial impairment.
    

Detailed description: 
      Cardiomyopathy is a category of multiple causes of myocardial injury in structure and
      function, of which unexplained cardiomyopathy was most worried by cardiologists. Since the
      etiology confirmation sometimes still lacks of effective tools, therefore it can not be
      treated against etiology and may gradually developing to systolic or diastolic heart failure.
      The development of heart failure can be in different speeds, varying degrees, inconsistent in
      reversibility, and distinct response to treatment of heart failure.

      In "real-world", ECG , cardiac ultrasound and myocardial enzymology can not be the whole to
      indicate the etiology of heart failure, so a strong clinical tool in the existing auxiliary
      examination is urgently needed and help to assess the risk of potential heart failure,
      therefore a reasonable treatment time window can be proposed.

      The investigators aimed to use CMR technique in helping diagnose the etiology of unknown
      cardiomyopathy. Try to make a risk stratification of susceptible heart failure based on the
      extent of myocardial impairment.
    

Intervention name(s): etiologic treatment,anti-myocardial remodeling; anti-myocardial remodeling; anti-myocardial remodeling,anti-acute heart failure; Etiological, anti-remodeling and symptom treatment
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): When the etiology was diagnosed clearly by cardiac magnetic resonance(CMR), participants were treated with drugs including etiologic treatment,anti-myocardial remodeling according to guidelines for treatment of cardiomyopathy.; When the etiology was not diagnosed clearly by cardiac magnetic resonance(CMR), in participant without companioned with acute heart failure, participants were treated with drugs including anti-myocardial remodeling according to guidelines for treatment of cardiomyopathy.; When the etiology was not diagnosed clearly by cardiac magnetic resonance(CMR), in participant companioned with acute heart failure, participants were treated with drugs including anti-myocardial remodeling and anti- acute failure according to guidelines.; When the etiology was diagnosed clearly by cardiac magnetic resonance(CMR), in participants were companioned with acute heart failure, the participant should be treated with drugs including etiologic treatment,anti-myocardial remodeling and anti-acute heart failure according to guidelines for treatment of cardiomyopathy.
Other intervention name(s): Etiology treatment, captopril, beta-blocker; Captopril, beta-blocker; captopril, fursemide, spironolactone; Etiology treatment,captopril, fursemide, spironolactone
Intervention MeSH terms: Captopril; Spironolactone; Furosemide; Adrenergic beta-Antagonists
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Cardiomyopathy; Heart Failure; Cardiac Magnetic Resonance