Maternal Nutrition Interventions in Uttar Pradesh, India
Condition: Anemia; Undernutrition; Underweight; Stunting; Maternal Malnutrition
MeSH terms: Malnutrition; Thinness
Study type: Interventional

Summary: 
      Maternal nutrition has been a long-standing concern of health authorities globally and in
      India. Despite the availability of proven, affordable interventions, and progressive policies
      and program platforms such as Maternal, Newborn and Child Health (MNCH) services, a
      streamlined package of proven maternal nutrition services is not reaching the majority of
      women during pregnancy.

      Alive & Thrive India aims to test the feasibility of integrating a package of maternal
      nutrition interventions in routine Reproductive, Maternal, Newborn and Child Health (RMNCH)
      services.These include provision of IFA and calcium supplements, interpersonal counseling on
      diet during pregnancy and consumption of IFA and calcium, community mobilization, and
      adequate weight-gain monitoring during pregnancy.

      This proposed evaluation aims to assess the feasibility of integrating maternal nutrition
      interventions into an existing RMNCH services in India, using a cluster-randomized evaluation
      design, complemented with a nested cohort study.
    

Detailed description: 
      Maternal nutrition has been a long-standing concern of health authorities globally and in
      India. Despite the availability of proven, affordable interventions, and progressive policies
      and program platforms such as Maternal, Newborn and Child Health (MNCH) services, a
      streamlined package of proven maternal nutrition services is not reaching the majority of
      women during pregnancy. This undermines national efforts to improve maternal and newborn
      survival; and reduce morbidity, malnutrition and disabilities in women and children.

      Reducing maternal and child mortality are the most important goals of the National Health
      Mission with major strategic investments being made by Government of India to achieve these
      goals. The Maternal Mortality Ratio in India has shown a considerable decline from
      424/100,000 live births in 1992-1993 to 167 in 2010-2013. These maternal deaths are
      exacerbated by the high burden of malnutrition and poor dietary intakes during and before
      pregnancy. The same nutritional deficits also contribute to low birth weight that in turn, is
      associated with higher infant mortality (which is at 37 per 1,000 live birth in 2015. Anemia
      remains a significant public health problem in India, affecting 53% women of reproductive age
      and 50% pregnant women, with a minimal decline during the last decade. Further more, nearly a
      third of women and 44.7% of girls aged 15 to 18 years have a low body mass index (BMI less
      than 18.5), thus entering pregnancy in a vulnerable state. During pregnancy, on average,
      women gained only 7 kg, much lower than the recommended weight gain of 10-12 kg.

      In 2016, the World Health Organization (WHO) issued new guidelines on antenatal care (ANC)
      for a positive pregnancy experience to improve nutrition through dietary interventions and
      micronutrient supplements, along with health system interventions to improve the utilization
      and quality of ANC. Indian policy framework includes food supplementation, iron and folic
      acid (IFA) and calcium supplementation to improve maternal nutrition. In addition, with the
      advent of the National Health Mission in 2006, the Reproductive, Maternal, Newborn and Child
      Health (RMNCH) gained priority and investments were made to expand the quality and coverage
      of maternal health services, including ANC contacts.

      Despite policy guidance, the nutrition content of ANC (e.g. IFA and calcium supplementation,
      monitoring and counseling on weight gain) remains to be prioritized. According to the
      National Family and Health Survey 2015-2016 (NFHS-4), nearly 90% of pregnancies in India were
      registered for health services, 51% received at least 4 ANC visits, but only 30% reported
      consuming 100 or more IFA tablets during their last pregnancy. In Uttar Pradesh, the
      proportion of women who received at least 4 ANC visits increased from 11% to 26% during the
      last decade. However, the proportion of women consuming IFA supplements more than doubled (6%
      to 13%) but is still very low. This suggests that there is a need to fully utilize the
      existing contacts to deliver maternal nutrition interventions within MNCH services.

      Alive & Thrive (A&T) supports scaling up of nutrition interventions to save lives, prevent
      illnesses, and contributes to healthy growth and development through improved maternal
      nutrition, breastfeeding and complementary feeding in several countries. In India, A&T aims
      to test the feasibility of integrating a package of maternal nutrition interventions that
      align with the latest global evidence and the national policies and guidelines of Government
      of India within routine RMNCH services. These include provision of IFA and calcium
      supplements, interpersonal counseling on diet during pregnancy and consumption of IFA and
      calcium, community mobilization, and adequate weight-gain monitoring during pregnancy.

      The primary objectives of the proposed evaluation are to answer the following questions using
      a cluster-randomized evaluation design:

        -  Can the coverage and utilization of key maternal nutrition interventions be improved by
           integrating nutrition-focused social behavior change communication (SBC) and systems
           strengthening approaches into ANC services under RMNCH program?

        -  What factors affect effective integration of maternal nutrition interventions into a
           well-established government ANC service delivery platform under RMNCH program?

        -  What are the impacts of program on: 1) consumption of diversified foods and adequate
           intake of micronutrient, protein and energy compared to recommended intake; 2) intake of
           IFA and calcium supplements during pregnancy; 3) weight gain monitoring; and 4) early
           initiation of breastfeeding.

      In addition, a nested cohort will be conducted to complement the overall impact evaluation
      with the following primary objectives:

        -  To collect objective measures of maternal nutrition outcomes such as weight gain during
           pregnancy, anemia, IFA and calcium consumption, and diet diversity and adequate intake
           (including macro- and micro-nutrient intakes).

        -  To understand the key barriers/facilitators which influence intentions and practices
           related to maternal nutrition.
    

Intervention name(s): Maternal Nutrition Behavior change
Intervention type(s): Behavioral
Intervention description(s): Counseling and community mobilization
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The impact evaluation follows a cluster randomized controlled trial design with repeated cross-sectional surveys at baseline and endline
The nested cohort study follows a prospective randomized controlled design (embedded in overall impact evaluation)
Masking: None (Open Label)
Primary purpose: Prevention