Endoscopic Diagnosis and Treatment of Acute Nonvariceal Upper Gastrointestinal Bleeding
Condition: Acute Upper Gastrointestinal Non Variceal Hemorrhage
MeSH terms: Gastrointestinal Hemorrhage; Hemorrhage
Study type: Observational

Summary: 
      Acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) is a common critical disease in
      gastroenterology. Due to the development of modern medical technology, the incidence rate of
      ANVUGIB has been decreasing in recent years, but its mortality within 30 days is still 11%.
      Endoscopic hemostasis and drug therapy are the first choice for the treatment of ANVUGIB.
      After endoscopic hemostasis, it is very important to treat peptic ulcer bleeding with strong
      acid suppression therapy to maintain gastric pH above 6.0. This study is to study the effect
      of endoscopic and drug treatment of ANVUGIB.
    

Detailed description: 
      Acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) is a common critical disease in
      gastroenterology. It refers to the bleeding caused by the non varicose diseases above the
      ligament of flexor, including the bleeding of pancreaticobiliary tract and the bleeding
      caused by the diseases near the anastomotic stoma after gastrojejunostomy. Due to the
      development of modern medical technology, the incidence rate of ANVUGIB has been decreasing
      in recent years. A US study shows that the incidence rate of ANVUGIB dropped from 78/10 to
      61/10 10000 [1] from 2001 to 2009. However, the mortality within 30 days of ANVUGIB is still
      as high as 11% [2]. Peptic ulcer bleeding is the most common cause of bleeding in ANVUGIB.
      The annual incidence rate is 19.4-57/10 million, and the rate of rebleeding within 7 days is
      13.9%, and the mortality rate is 30 in 30 days. A study in China shows that compared with the
      1990s, the detection rate of high-risk ulcer has increased, but the overall mortality has not
      decreased significantly [4]. Endoscopic hemostasis is the first choice for the treatment of
      peptic ulcer. The latest guidelines of our country recommend that patients with upper
      gastrointestinal bleeding with stable hemodynamics should try their best to have emergency
      gastroscopy within 24 hours after bleeding, and emergency endoscopic hemostasis is feasible
      for bleeding lesions [5]. After endoscopic hemostasis, it is very important to give strong
      acid suppression therapy to maintain gastric pH above 6.0 in the treatment of peptic ulcer
      bleeding [6-9]. This study is to analyze the effect of endoscopic and drug treatment of
      ANVUGIB.
    

Intervention name(s): No intervention
Intervention type(s): Other
Intervention description(s): Our study is an observational study and the main purpose of our study is to observe the efficacy of endoscopic hemostasis and drug therapy
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        The people who come to Nanchang University First Affiliated Hospital for medical treatment
      
Keywords: Acute upper gastrointestinal non variceal hemorrhage; peptic ulcer; Dieulafoy's lesion; Gastric ulcer bleeding; Endoscopic hemostasis