Comparison of Clinical Efficiency of Photodynamic Therapy and Topical Corticosteroid in Treatment of Oral Lichen Planus
Condition: Lichen Planus, Oral
MeSH terms: Lichen Planus, Oral; Lichen Planus
Study type: Interventional
Phase: Phase 2

Summary: 
      Lichen planus is a chronic inflammatory dermatosis. It most often affects the skin and mucous
      membranes. Sometimes lesions may appear in the area of nails (estimated at 10% of patients)
      or genital organs and anus.

      The most dangerous form of lichen planus is lichen that develops on the oral mucosa. It is
      believed to be the cause of the development of oral cancer.

      The vast majority of people suffering from lichen planus - 90%, experience spontaneous
      resolution of symptoms within a maximum of two years from the moment of their onset.

      In about half of the patients, the changes disappear within about 6 months. People who have a
      problem that their ailments do not want to go away on their own must take into account the
      fact that treating lichen is not the easiest one.

      Treatment of lichen is mainly based on alleviating its symptoms and accelerating the
      resolution of symptoms. Topical ointments containing strong glucocorticosteroids are usually
      applied to skin lesions or we can use Photodynamic Therapy
    

Detailed description: 
      Oral lichen planus is most often characterized by lesions resembling a painless white mesh,
      which is usually located on the inside of the cheeks and the sides of the tongue. Lumps,
      erosions or erythematous changes are less often noticeable.

      Symptoms in oral lichen planus are often:

      reddening, dry mouth baking, swelling and minor bleeding.

      Sometimes the gum mucosa exfoliates. When erosions occur, patients complain of pain and
      problems with drinking and swallowing food. Oral lesions necessarily require treatment.

      Since lichen planus comes in many forms, some of them require histopathological examination
      to identify some of them. These tests involve taking a slice of the affected skin and
      examining it under a microscope.

      Some causes of lichen planus are thought to involve several components.

      Medications: lichen planus can occur as a reaction to certain medications, including:

      beta-blockers, which are common drugs used to treat cardiovascular problems;
      anti-inflammatory drugs; injections to treat arthritis; antimalarial drugs; thiazide
      diuretics; phenothiazines, a group of tranquilizers with antipsychotic effects.

      A prospective, randomized, single-blind 12-week clinical trial of full contralateral
      split-mouth in patients with bilateral erythematous or erosive lichen planus in the mouth.On
      one side, the OLP lesion eligible for treatment was subjected to photodynamic therapy using
      toluidine blue in four sessions every 2 days.

      olp on the other side was treated with the administration of the steroid triamcinolone for 8
      days

      The clinical evaluation of the evolution of OLP eruptions was performed within 12 weeks of
      qualifying for treatment: at baseline, at the end of both treatments (day 8) and after the
      next 11 weeks
    

Intervention name(s): Triamcinolone Acetonide; Photodynamic Therapy
Intervention type(s): Drug; Procedure
Intervention description(s): The OLP on the other side was treated by daily sticking a cut-to-size carrier with 0.05% triamcinolone acetonide for 8 days; the olp was photosensitized with methylen blue and was irradiated with a semiconductor laser with a wavelength of 650 nm, using a dose of 120 J / cm2 and power density
Other intervention name(s): topical steroid administration; PDT
Intervention MeSH terms: Triamcinolone; Triamcinolone Acetonide; Triamcinolone hexacetonide; Triamcinolone diacetate
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: full contralateral split-mouth
Masking: Double (Participant, Investigator)
Primary purpose: Treatment