bioihbjkbjnl/mcl2 huggingface dataset:
PD1 Integrated Anti-PSMA CART in Treating Patients With Castrate-Resistant Prostate Cancer
Condition: Castrate-Resistant Prostate Cancer
MeSH terms: Prostatic Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      PD1-PSMA-CART in Treating Patients With Castrate-Resistant Prostate Cancer
    

Detailed description: 
      Clinical trial for the safety and efficacy of Non-viral programmed cell death protein-1(PD1)
      integrated anti-prostate-specific-membrane-antigen(PSMA) chimeric antigen receptor T(CART)
      cells in the treatment of Refractory Castrate-Resistant Prostate Cancer(CRPC)
    

Intervention name(s): PD1-PSMA-CART cells
Intervention type(s): Drug
Intervention description(s): PD1-PSMA-CART cells will be given IV at split doses
Other intervention name(s): Non-viral PD1 integrated anti-PSMA chimeric antigen receptor T cell
Intervention model: Sequential Assignment
Intervention model description: Group A: 0.5×10^6 cells / kg; Group B: 1.0×10^6 cells / kg; Group C: 2.0×10^6 cells / kg.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Castrate-Resistant Prostate Cancer
Scan-Rescan Sub-Study of MS PATHS
Condition: Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Sclerosis
Study type: Observational

Summary: 
      The primary objective of this sub-study is to calculate the reproducibility and other
      technical performance measures of various magnetic resonance imaging (MRI) image analysis
      algorithms in order to assess their suitability for detecting changes due to multiple
      sclerosis (MS) in a real-world setting in participants with MS. The secondary objective of
      this sub-study is to use the primary endpoint results to calibrate measurements across
      scanners within each MS PATHS center.
    


Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Potential participants will be participants with MS enrolled in Study 888MS001 who have
        varying levels of disease severity and symptom duration.
Effect of Exercise Mode in Breast Cancer-Related Lymphedema
Condition: Breast Cancer Lymphedema; Quality of Life
MeSH terms: Breast Neoplasms; Lymphedema; Breast Cancer Lymphedema
Study type: Interventional

Summary: 
      Gaining a greater understanding of how each exercise mode affects lymphedema, as well as
      other health-related outcomes will improve exercise prescription guidelines relevant to this
      specific lymphedema. Therefore, the purpose of this work was to compare the effects of Xbox
      kinect rehabilitation and resistance exercises on limb volume, symptoms severity, physical
      function, and quality of life in women with Breast cancer-related lymphedema.
    

Detailed description: 
      Breast cancer-related lymphedema is a common and debilitating side effect of cancer
      treatment. This study compared the effect of Xbox kinect rehabilitation and resistance
      exercises on breast cancer-related lymphedema volume and severity, as well as participant's
      physical function and quality of life. Women diagnosed with unilateral breast cancer related
      lymphedema were randomly divided into two groups: the kinect based rehabilitation group KBRG
      and resistance exercise group REG. woman in The KBRG received virtual reality therapy using
      Xbox Kinect-based games, the REG received resistance training in addition both groups
      received complex decongestive physiotherapy. The intervention was five sessions per week for
      8 weeks. The outcome measures included limb volume, symptoms severity, physical function
      (muscle strength and range of motion) and quality of life. All these outcomes were assessed
      at pretreatment (baseline) and after the end of treatment at week eight (W8).
    

Intervention name(s): Virtual Reality; Resistance Exercise
Intervention type(s): Other; Other
Intervention description(s): Intervention was led once per day, five days a week, over 8 weeks.; Intervention was led once per day, five days a week, over 8 weeks.
Other intervention name(s): complex decongestive physiotherapy; complex decongestive physiotherapy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
A Study in People With Normal Kidney Function and People With Reduced Kidney Function to Test How BI 764198 is Processed in the Body
Condition: Healthy; Chronic Kidney Disease
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic
Study type: Interventional
Phase: Phase 1

Summary: 
      The main objective of this trial is to investigate the influence of moderate and severe renal
      impairment on the pharmacokinetics of a single dose of BI 764198 in comparison to a group of
      matched controls with normal renal function.
    


Intervention name(s): BI 764198
Intervention type(s): Drug
Intervention description(s): Capsules
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Comparison of Taping Techniques in Plantar Fasciitis
Condition: Plantar Fasciitis; Pain; Foot Diseases
MeSH terms: Fasciitis; Fasciitis, Plantar; Foot Diseases
Study type: Interventional

Summary: 
      The aim of this study is to investigate the effects of Low-Dye and Kinesio Taping on pain and
      function in individuals with plantar fasciitis.
    

Detailed description: 
      Subject: In this study, the effects of Low-Dye Taping and Kinesio Taping (KT) on pain and
      function will be investigated in individuals with plantar fasciitis. There are studies on
      both Low-Dye banding and KT in the literature and they are popular applications recently.
      However, to the best of our knowledge, when we look at the Turkish and English literature, no
      study has been found comparing these two therapeutic massages in terms of pain, functionality
      and performance.

      Purpose: Plantar fasciitis (PF) is a clinical picture characterized by degeneration of the
      plantar fascia resulting from repetitive microtrauma to the plantar fascia causing an
      inflammatory reaction. It is one of the most common causes of heel pain in adults. The
      plantar fascia has a fundamental role in the biomechanics of the foot, supporting the medial
      longitudinal arch (MLA), distributing forces and stresses of the foot during gait or other
      loading conditions. Disorders in the musculoskeletal and somatosensory system in patients
      with plantar fasciitis may cause pain and decrease in functional capacity. Therefore, its
      purpose is; This study was planned to show the effectiveness of taping methods applied in
      addition to ESWT in individuals presenting with heel pain. Thanks to the findings to be
      obtained from our study, it is aimed to contribute to the literature with objective,
      evidence-based results in this field.
    

Intervention name(s): Extracorporeal Shockwave Therapy (ESWT); Low-Dye Taping; Kinesio Taping
Intervention type(s): Device; Other; Other
Intervention description(s): Extracoporeal shock wave, 2000 shots/time, once a week for 3 weeks, shock wave freqency: 10Hz, total energy: 166 mJ/mm2, Pressure 2.5 Bar; After ESWT application, Low-Dye Taping will be applied 3 times, once a week.; After ESWT application, Kinesio Taping will be applied 3 times, once a week.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Pilot: Digital Therapeutic vs Education for the Management of Problematic Substance Use
Condition: Alcohol Use Disorder (AUD); Substance Use Disorders
MeSH terms: Substance-Related Disorders; Alcoholism
Study type: Interventional

Summary: 
      Prior to launching a randomized controlled trial, this pilot study will investigate the
      feasibility and acceptability of the administration of a diagnostic interview and collection
      of a biomarker test, as well as engagement and preliminary efficacy with W-SUDs and the
      education arm, among a sample of adults who screen positive for problematic substance use.
    


Intervention name(s): W-SUDs; Digitally-delivered Psychoeducation
Intervention type(s): Device; Other
Intervention description(s): Woebot (W-SUDs) is an automated conversational agent, available through a smartphone application, that delivers evidence-based psychotherapeutics, empathy, and emotional health psychoeducation.; A form of psychoeducation for those seeking treatment for their alcohol and/or substance use concern. Psychoeducation is commonly provided for those with substance use. Psychoeducation in substance use is intended to increase the users' knowledge of their substances of use, and effects on the body, behaviors, and consequences. The recipient of psychoeducation is expected to increase their own awareness of their substance use and ideally incorporate this newfound knowledge when making changes to their substance use. The information provided in this group are from factsheets found on NIAAA, NIDA, and CDC web pages.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Immunogenicity and Safety of Menactra® Vaccine in Subjects Aged 9 to 23 Months in India and in the Russian Federation
Condition: Meningitis; Meningococcal Infection
MeSH terms: Meningococcal Infections; Meningitis
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to assess the immunogenicity and safety of Menactra® vaccine
      given as a two-dose series in infants and toddlers.

      Primary Objectives:

        -  To assess the seroprotection rate (percentage of subjects with a serum bactericidal
           assay using human complement [SBA-HC] titer ≥ 1:8) 28 days after the second of 2 doses
           of Menactra® administered 3 to 6 months apart.

      Secondary Objectives:

        -  To assess the immune responses to meningococcal antigens (serogroups A, C, Y, and W-135)
           28 days following the second vaccination with Menactra® using SBA-HC and SBA-BR titers.

        -  To assess the safety profile of Menactra® after each and any vaccination.
    

Detailed description: 
      Study participants will receive 2 doses on Menactra® vaccine at 3 to 6 months apart and will
      be monitored for safety and immunogenicity.

      The planned duration of each subject's participation in the trial will be from 118 to 215
      days.
    

Intervention name(s): Meningococcal Diphtheria Toxoid Vaccine
Intervention type(s): Biological
Intervention description(s): 0.5 mL, Intramuscular
Other intervention name(s): Menactra®
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Meningitis; Meningococcal Infection; Menactra®
Electromyographic Analysis And Body Balance In The Use Of Athletes After Cryotherapy By Immersion Ankle
Condition: Individual Adjustment; Itch; Athlete
Study type: Interventional

Summary: 
      The influence of cryotherapy on ankle motor control and balance of athletes is controversial.
      The aim of this study is to assess the neuromuscular response of the dominant leg and body
      balance basketball athletes after application of cryotherapy. The sample is distributed into
      two groups. Group one will consist of 20 basketball players without a history of ankle
      sprains in the past 12 months and no complaints of instability in this joint, and group two,
      20 non-athletes, active, no complaints in the lower limb in the last 12 months. Will perform
      the inversion movements and single-leg hop for the analysis of the electromyographic signal
      of anterior tibial, peroneal, gastrocnemius (lateral), rectus femoris, hamstrings and gluteus
      medius. Will also be performed kinematic analysis in search of body balance and range of
      motion of the joints of the lower limbs. And yet, the analysis of the plantar support and
      ground reaction force. After the initial collection of the data subjects will be submitted to
      the application of cryotherapy by immersion in a time of 20 minutes, with a temperature of 6
      ± 2 degrees Celsius. Data collection will be held in pre, 0, 10, 20 and 30 minutes after
      application of cryotherapy. The data will be statistically analyzed to compare the results in
      collection times within and between groups. The significance level is set at 5%. The data
      support the intended use of cryotherapy in motor control of the inversion movement, jump and
      balance of athletes.
    

Detailed description: 
      Forty male subjects, aged 21.6 (±3.2) yr, 177.9 (±7.9) cm tall, 82.8 (±19.3) Kg body weight
      and 25.9 (±4.8) Kg.m-2 body mass index (BMI) were evaluated. Skin surface temperature before
      and after cold-water immersion was 27.7(±3)°C and 7.1 (±1)°C, respectively (p=0,0001).
    

Intervention name(s): cryotherapy by immersion
Intervention type(s): Other
Intervention description(s): the dominant leg was immersed in cold water for 20 minutes [2, 17], temperature of 4º C [22, 24], water level at 20 cm
Other intervention name(s): Cryoimmersion, 20 minutes, temperature was 4C.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Pharmacokinetics of a Novel Vaginal Delivery System for Testosterone and Dehydroepiandrosterone (DHEA)
Condition: Pharmacokinetics; Hormone Deficiency
Study type: Interventional
Phase: Phase 1

Summary: 
      This study was performed to determine the pharmacokinetic parameters of vaginal rings that
      contain DHEA, testosterone, or combinations of both androgens, in comparison to the oral
      administration of DHEA and the transdermal administration of testosterone.
    


Intervention name(s): Dehydroepiandrosterone 2.2 g; Dehydroepiandrosterone 1.5 g/Testosterone 25 mg; Testosterone; Testosterone Topical Gel; Dehydroepiandrosterone Oral Capsule
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): Vaginal ring with 2.2 grams DHEA.; Vaginal ring with DHEA 1.5 grams/Testosterone 25 mg.; Vaginal ring with 35 mg testosterone.; Gel containing 1% testosterone.; Capsule containing 25 mg DHEA
Other intervention name(s): ActiserPump®
Intervention MeSH terms: Methyltestosterone; Testosterone; Testosterone undecanoate; Testosterone enanthate; Testosterone 17 beta-cypionate; Dehydroepiandrosterone
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: This is a prospective, randomized, open-label comparative, single-site study with 5 treatment groups. Each participant receives a single Treatment for 72 hours. Allocation to Treatment is in a 1:1:1:1:1 order.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Gynaecology; Obstetrics
Effect of Phacoemulsification on Ocular Blood Flow in Human
Condition: Cataract; Hypertension; Diabetes
MeSH terms: Cataract
Study type: Observational

Summary: 
      -  To investigate ocular haemodynamics after phacoemulsification surgery

        -  To evaluate the influence in people with different autoregulation of ocular blood flow
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        patients who underwent phacoemulsification surgery in Eye Hospital of Wenzhou Medical
        College
      
Keywords: blood flow
Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-Angle Glaucoma or Ocular Hypertension
Condition: Open-Angle Glaucoma; Ocular Hypertension
MeSH terms: Glaucoma; Glaucoma, Open-Angle; Ocular Hypertension; Hypertension
Study type: Interventional
Phase: Phase 2

Summary: 
      To investigate the dose-response relationship of DE-104 ophthalmic solution in lowering
      intraocular pressure (IOP) in subjects with Primary Open-Angle Glaucoma or Ocular
      Hypertension
    


Intervention name(s): DE-104 ophthalmic solution, low concentration; DE-104 ophthalmic solution, medium concentration; DE-104 ophthalmic solution, high concentration; DE-104 vehicle
Intervention type(s): Drug; Drug; Drug; Drug
Intervention MeSH terms: Pharmaceutical Solutions; Ophthalmic Solutions
Auto-immune Diseases and Quality of Life
Condition: Systemic Auto-immune Diseases; Quality of Life
MeSH terms: Immune System Diseases; Autoimmune Diseases
Study type: Observational

Summary: 
      Systemic lupus erythematous (SLE), systemic sclerosis (Ssc) and inflammatory myopathy (IM)
      are rare diseases, whose prevalence is estimated at 43, 15 and 10 cases, respectively, for
      100 000 inhabitants in France. These diseases belong to the group of auto-immune diseases and
      require specialized follow-up in an expert centre. The repercussions of SLE, Ssc and IM on
      the everyday life of patients are heavy, and notably linked to skin involvement, to
      diminished functional capacities and psychological problems. The vast majority of these
      diseases concern middle-aged, professionally-active individuals, for whom the
      socio-professional repercussions are major and too often neglected. The aim of this study is
      to analyse the consequences of auto-immune diseases on quality of life. Current quality of
      life questionnaires are not suitable, and do not reveal the reality of the situation and its
      different nuances. In this research, the quality of life of patients will be envisaged
      through their everyday lives. How do these patients construct the social reality of the
      disease? How do they perceive their health status and their social situation? How do they
      organize their everyday lives around the disease: work, leisure, relationships with their
      entourage... ?
    


Intervention name(s): completion of the quality of life questionnaire
Intervention type(s): Other
Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        patients with Systemic lupus erythematous (SLE), systemic sclerosis (Ssc) and inflammatory
        myopathy (IM)
Effect of Muscle Energy Technique Versus Strain-counterstrain on Upper Trapezius Trigger Points
Condition: Trigger Point Pain, Myofascial
MeSH terms: Myofascial Pain Syndromes
Study type: Interventional

Summary: 
      Aim of the study To determine the comparative effects of muscle energy technique and strain
      counter strain in upper trapezius trigger point.
    

Detailed description: 
      A Randomized Controlled trial will be conducted after approval of synopsis. To enroll
      patients Purposive sampling technique will be used. Patients will be selected according to
      the pre-defined inclusion and exclusion criteria. The enrolled patients will be allocated
      into two groups, group A and group B. On Group A muscle energy technique will be applied for
      30 seconds and repeat 3 to 5 times per on treatment session and Group B will be treated with
      strain counter strain for 20-30 seconds and repeat this process for up to five times.
      Assessment will be done at baseline, 2nd week, 4th week and 6th week of treatment. Follow up
      will be assessed 15 days after completion of treatment protocol. The patients' outcome will
      be measured by Visual Analog Scale for pain intensity and Neck Disability Index . Informed
      consent will be taken from each patient. Statistical Package of Social Sciences software,
      version 20 will be used for the analysis of data.
    

Intervention name(s): Strain-counterstrain; Muscle Energy Technique
Intervention type(s): Other; Other
Intervention description(s): Strain-counterstrain is also used for manual Trigger Point processing. This involves identifying active TRP and then applying pressure until a ridiculous reaction occurs. The area is then positioned to reduce tension in the injured muscle and later reduce tripod pain. When the pain subsides, the tissues that are most stressed feel relaxed and there is a local decrease in the ground; Muscle Energy Technique is a common way to achieve muscle tension release (stop) before stretching other's adductor muscles
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Muscle Energy Technique; Myofascial; Trigger Point; Upper Trapezius; Strain-counterstrain
Pomaglumetad Effects on Glutamate Biomarkers
Condition: Healthy Controls
Study type: Interventional
Phase: Phase 1

Summary: 
      The study will evaluate the effects of the mGluR2/3 partial agonist LY2140023 (Pomaglumetad
      Methionil, "POMA") at selected doses on ketamine-stimulated glutamate release in prefrontal
      cortex as measured by pharmacoBOLD fMRI (also termed resting BOLD fMRI).
    

Detailed description: 
      This study evaluates the effects of POMA at selected doses on ketamine-stimulated glutamate
      increase in the prefrontal cortex hypothesized to simulate the synaptic dysregulation that
      occurs endogenously in the pathogenesis of schizophrenia. The purpose of this is: 1) to
      determine whether the low dose (40 mg BID) utilized in recent (failed) clinical trials is
      sufficient to engage the primary target and 2) whether a higher (160 mg BID) dose,
      representing the maximum tolerated dose of POMA, engages the target to a greater degree. This
      study will further validate pharmacoBOLD as biomarker of mGluR2/3 target engagement,
      permitting its future use in other glutamatergic drug development.
    

Intervention name(s): POMA; placebo
Intervention type(s): Drug; Drug
Intervention description(s): Pomaglumetad ("POMA") is a mGluR 2/3 partial agonist; matching placebo tablets
Other intervention name(s): Pomaglumetad; placebo comparator
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Effect of Oat Beta Glucan in Managing Blood Pressure
Condition: Elevated Blood Pressure
MeSH terms: Hypertension
Study type: Interventional

Summary: 
      This is a randomized, double-blinded, cross-over pilot study comparing the effects of
      ingesting oats containing high molecular weight β-glucan in reducing blood pressure.
    

Detailed description: 
      The pilot study will consist of 2 study periods: one treatment period and one control period.
      The treatment period will provide food products made from oats containing a total of 4 grams
      per day high molecular weight (HMW) oat β-glucan, whereas, the control period will provide
      food products made primarily from wheat with no β-glucan. The study will be located at the
      Chronic Disease Innovation Centre in Seven Oaks General Hospital, Winnipeg, Canada.

      The primary objective of this study is to investigate the effect of ingestion of HMW oat
      β-glucan on ambulatory blood pressure. Participants will be asked to wear an ambulatory blood
      pressure monitor for 24 hours per day for 3 consecutive days at the beginning and end of each
      treatment period. This device automatically measures blood pressure every 15-30 minutes
      during the day and 30 to 60 minutes during the evening.

      The study has been designed to be conducted virtually. Participants will consent to receive
      both treatment and control over two 4-week periods online. The participants will be
      randomized to different orders of treatment, with a 4 week wash out period in between.
    

Intervention name(s): High molecular weight β-glucan oat cookies; Control wheat based cookies
Intervention type(s): Other; Other
Intervention description(s): Two cookies that contains 4g beta glucan made from oats will be consumed per day.; Two cookies that made from cream of wheat without beta glucan will be consumed per day.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science