bioihbjkbjnl/mcl2 huggingface dataset:
Assessment of Safety Distance of Far-Infrared Therapeutic Device to Human Skin
Condition: Far- Infrared Burn
Study type: Observational

Summary: 
      Abstract The equipment "infrared therapeutic device" is widely used in various medical
      institutions in Taiwan. The infrared therapeutic device improves the blood circulation,
      relieves muscle stiffness and pain by the heat energy radiated by the infrared light, and has
      a significant relief effect on patients with joint pain, muscle soreness, and back
      discomfort. However, the principle of the infrared therapeutic device is thermal energy, and
      there is no complete literature on the parameters such as treatment intensity and time and
      the full distance. In addition, the literature on the damage that can be caused is not based
      on clinical evidence, and there is no standardization study on the use of equipment, so it is
      hoped that this test will explore the safety distance of infrared therapeutic devices.

      The project is expected to recruit 50 people from 20 years old to 75 years old in the Chinese
      Medicine Clinic of Tainan Hospital of the Ministry of Health and Welfare, which is included
      in the diagnosis of osteoarthritis, degenerative arthritis, osteoporosis and other related
      Chinese medicine clinics. In patients with diseases, the main complaint must include patients
      with lower back pain and back pain. Subjects should exclude diseases that may be affected by
      chemoradiotherapy, cardiovascular disease, anemia, hypertension, etc., and exclude
      dermatitis, skin irritation, and erythema. Skin diseases such as lupus. The test site is the
      TCM clinic of Tainan Hospital of the Ministry of Health and Welfare. The air conditioner is
      fixed at a constant temperature of 28 degrees. The output power is calculated by the wattage
      meter, and the distance and temperature of the infrared lamp are measured. Finally, the
      appropriate temperature and distance of the infrared lamp to the human skin are estimated
      through calculation.

      Keywords: Infrared, Far- infrared, Burn
    


Intervention name(s): Far- infrared
Intervention type(s): Radiation
Intervention description(s): safety of far- infrared
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Recruitment of the Department of Traditional Chinese Medicine, Tainan Hospital, Ministry of
        Health and Welfare
ED95 of Lidocaine 1.0% for Filling the Adductor Canal
Condition: Healthy
Study type: Interventional
Phase: Phase 2

Summary: 
      The aim of this prospective dose finding study is to estimate the minimal effective volume
      (ED95) for lidocaine 1.0% for filling the adductor canal when placing an adductor canal
      block. We will apply the Continual Reassessment Method (CRM) for estimating the ED95 and use
      an MRI scan to evaluate the main objective and ensure spread to the distal part of the
      adductor canal.
    


Intervention name(s): Adductor canal block with lidocaine 1%; Lidocaine
Intervention type(s): Procedure; Drug
Intervention description(s): US-guided adductor canal block
Intervention MeSH terms: Lidocaine
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: adductor canal block; volunteers; US-guided peripheral nerve block; lower limb; MRI
Physiological Effects of High-flow Nasal Cannula During Exercise
Condition: Healthy Volunteers
Study type: Interventional

Summary: 
      The high-flow nasal cannula (HFNC) has increased its evidence in patients during pulmonary
      rehabilitation. These studies hypothesize that the physiological effects of HFNC (positive
      expiratory pressure, anatomical dead space lavage, thermo-humidification) lead to an increase
      in exercise time. This is believed to be due to improvements that the device can generate in
      the respiratory system and muscles. However, the physiological effects of HFNC on respiratory
      effort and distribution of pulmonary ventilation during exercise are unknown. The aim of this
      study is to determine the acute effect of high flow nasal cannula on the distribution of
      pulmonary ventilation and respiratory effort during physical exercise in healthy subjects.
    

Detailed description: 
      A randomized, cross-over clinical trial in which either HFNC or Sham may be used as an
      adjunct on a cycle ergometer in random order will be performed to compare the respiratory
      effort and distribution of pulmonary ventilation continuously. Measurements will be taken in
      a warm-up, exercise, and recovery phase for both groups.
    

Intervention name(s): High-flow Nasal Cannula
Intervention type(s): Device
Intervention description(s): HFNC is a device that, in this study, will give the maximum flow (60 L/min), with minimum adjusted temperature (31°C) and FiO2 of 21% or room air.
Other intervention name(s): HFNC
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Participants receive one of two alternative interventions during the initial phase of the study and receive the other intervention during the second phase of the study
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: High-Flow Nasal Cannula; Electrical Impedance Tomography; Respiratory Physiology; Exercise
ACTIV- Exercise Intervention in Healthy Young Men
Condition: Insulin Resistance
MeSH terms: Insulin Resistance
Study type: Interventional

Summary: 
      The study is designed to compare muscle energy capacity in men with obesity or diabetes as
      compared to athletes. This study will also enable researchers to determine whether MRS can
      replace muscle biopsy for this type of assessment.
    

Detailed description: 
      Skeletal muscle mitochondrial defects are a sine qua non of insulin resistance in patients
      with type 2 diabetes mellitus (T2DM), obese and subjects with family history of T2DM (FH+).
      Exercise increases mitochondrial capacity whereas lipid infusion or high fat diet decreases
      genes involved in mitochondrial biogenesis. In this study 2 cohorts will be involved: Cohort
      I (athletes, T2DM and obese) and Cohort II (healthy with "FH+" or without "FH-" family
      history of T2DM). This randomized, parallel arm clinical trial will consist of 4 periods:
      screening, stabilization (3 days), baseline (for Cohort I and II) and exercise period (14
      days, only for Cohort II). The overall objective of the study is to validate a paradigm for
      the evaluation of compounds and drugs that activate mitochondrial biogenesis in skeletal
      muscle. In Specific Aim 1 we will compare and contrast biopsy and MRS power to detect
      differences in mitochondrial capacity in 78 subjects: athletes (N=10), FH- (N=24), FH+
      (N=24), obese (N=10) and T2DM (N=10). In Specific Aim 2 we will compare mitochondrial changes
      in response to exercise in subjects FH - vs. FH + subjects. In Specific Aim 3 we will
      determine if HFD impairs mitochondrial changes in response to exercise in FH+ subjects. In
      Specific Aim 4 we will determine the role of mitochondrial capacity in metabolic flexibility
      and insulin sensitivity in T2DM, obese, FH+, FH- and athlete subjects.
    

Intervention name(s): Exercise
Intervention type(s): Behavioral
Intervention description(s): Interval Exercise Training: Each interval training session will start with 10 minutes of warm up and will end with 10 minutes of cool down period at 40% VO2 peak. Training duration, intensity and number of exercise bout will increase with the progression of training period
Aerobic training: Each endurance training session will start with 5 minutes of warm up and will end with 5 minutes of cool down at 40% VO2 peak. Subjects will exercise at 70% VO2 peak for 45 minutes on day 3 and 5, for 55 minutes on day 8 and 10, and for 35 minutes on day 14 using a bicycle ergometer.
Other intervention name(s): Aerobic and interval exercise training
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Kiwifruit Effect on Periodontal Inflammation Kiwifruit Effect on Periodontal Inflammation
Condition: Periodontitis
MeSH terms: Periodontitis
Study type: Interventional

Summary: 
      The importance of micronutrients has been extensively reviewed and it was concluded that for
      prevention and treatment of periodontitis daily nutrition should include sufficient
      antioxidants, vitamin D and calcium.

      Up to now there is limited research available investigating the effect of vitamin C
      supplementation on the periodontal condition. Supplementation of vitamins and micronutrients
      has however raised numerous questions on clinical efficacy. Recently, a significant increase
      of medical literature on the effect of nutraceutical dietary aliments on general health has
      been noted.

      the aim of the present study is twofold. The first objective is to investigate the effect of
      twice-daily kiwifruit consumption as sole treatment modality in untreated periodontitis,
      followed after two months by initial periodontal therapy supported by continued kiwifruit
      consumption. The second objective is to investigate the effect of twice daily kiwifruit
      consumption on periodontal and systemic parameters of these periodontitis patients 3 months
      after treatment.
    


Intervention name(s): Kiwifruit addition to the diet; Non Surgical periodontal treatment
Intervention type(s): Dietary Supplement; Procedure
Intervention description(s): Subjects were instructed to eat two kiwifruit per day during the whole study period. No recommendation on the type of kiwifruit, brand or origin was delivered. Kiwifruit was suggested to be taken as a whole and not mixed with sugar or other ingredients. No changes to their routinely dietary habits were suggested.; Non-surgical treatment of periodontal pockets with hand and ultrasonic instrumentation
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Single-centre randomized, parallel design, clinical trial with a 5-month follow
Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Mechanical Ventilation Controlled by the Electrical Activity of the Patient's Diaphragm - Effects of Changes in Ventilator Parameters on Breathing Pattern
Condition: Mechanical Ventilation
Study type: Interventional
Phase: Phase 1

Summary: 
      Neurally adjusted ventilatory assist (NAVA) is a new concept of mechanical ventilation. NAVA
      delivers assist to spontaneous breathing based on the detection of the electrical activity of
      the diaphragm. We study the effect of changing ventilatory parameters on the patient's
      breathing pattern during NAVA.
    


Intervention name(s): neurally adjusted ventilatory assist (NAVA)
Intervention type(s): Device
Intervention description(s): assessment of breathing pattern at various ventilator settings
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Cognitive Behavioral Therapy Plus Motivational Interviewing for Treatment of Obsessive-Compulsive Disorder
Condition: Obsessive-Compulsive Disorder
MeSH terms: Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will determine the effectiveness of adding motivational interviewing to cognitive
      behavioral therapy, consisting of exposure and ritual prevention, in improving treatment
      outcomes in people with obsessive-compulsive disorder.
    

Detailed description: 
      Obsessive Compulsive Disorder (OCD) is a chronic and debilitating anxiety disorder. People
      with OCD often experience recurrent unwanted thoughts, or obsessions. Some examples of
      obsessions include the following: repetitive fears of causing harm or being harmed; fears of
      contamination and illness; fears of making mistakes; intrusive distressing sexual or
      religious imagery; and fears of losing things. In an effort to relieve anxiety about these
      obsessions, people with OCD develop repetitive behaviors called compulsions. Some examples of
      compulsions include the following: repetitive washing and cleaning; excessive checking;
      excessive ordering and arranging; and extreme hoarding and saving. These thoughts and
      behaviors interfere with everyday life to a great extent. Cognitive behavior therapy (CBT)
      with exposure and ritual prevention (EX/RP) is a standard treatment for OCD. EX/RP involves
      both imaginary and real exposure to situations or settings that may stimulate OCD behavior,
      and it requires that patients refrain from ritualizing. Motivational interviewing (MI) may
      help to enhance an individual's motivation to change by exploring and resolving ambivalence.
      This study will determine the effectiveness of adding MI to CBT that consists of EX/RP in
      improving treatment outcome in people with OCD.

      Participants in this single-blind study will be randomly assigned to receive either standard
      CBT with EX/RP or CBT with EX/RP plus MI. All participants will report to the study site
      twice weekly for both therapy and assessments for a total of 2 months. Assessments will
      include interviews and self-rating forms. No medication will be administered during this
      study. However, participants will continue on any medication that they are taking at the time
      of study entry. All participants will be assessed for outcomes upon study completion.
      Participants who respond to therapy will be assessed again 6 months following study
      completion.
    

Intervention name(s): Motivational interviewing plus exposure and response prevention (MI plus EX/RP); Exposure and response prevention (EX/RP)
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Participants will receive 18 sessions of MI plus EX/RP.; Participants will receive 18 sessions of EX/RP.
Other intervention name(s): MI plus EX/RP; EX/RP
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: OCD
A Phase 1 Dose Escalation Study of VX-708 in Healthy Participants
Condition: Pain
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the safety, pharmacokinetics, and pharmacodynamics
      of multiple ascending doses of VX-708 in healthy participants
    

Detailed description: 
      This clinical trial information was submitted voluntarily under the applicable law and,
      therefore, certain submission deadlines may not apply. (That is, clinical trial information
      for this applicable clinical trial was submitted under section 402(j)(4)(A) of the Public
      Health Service Act and 42 CFR 11.60 and is not subject to the deadlines established by
      sections 402(j)(2) and (3) of the Public Health Service Act or 42 CFR 11.24 and 11.44.).
    

Intervention name(s): VX-708; Itraconazole; Midazolam; Placebo
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Solution for intravenous (IV) administration.; Solution for oral administration.; Solution for oral administration.; Placebo matched to VX-708 for IV administration.
Intervention MeSH terms: Itraconazole; Midazolam
Allocation: Randomized
Intervention model: Sequential Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Delivery Room Skin-to-skin Study
Condition: Very Low Birthweight Infants; Mother Child Interaction; Preterm Infant
MeSH terms: Birth Weight
Study type: Interventional

Summary: 
      The first hours after birth are a sensitive period for promotion of optimal
      mother-child-interaction and secure attachment. Maternal sensitivity and responsivness are
      high in the first hours after birth due to high oxytocin levels. Developing optimal
      mother-child-interaction is more difficult for preterm mothers because mother and child are
      separated after birth and the preterm infant is not able to show strong signs to promote
      maternal sensitivity. We hypothesize that promoting skin-to-skin contact of VLBW infants and
      their mothers for 60 minutes within the first hours after birth improves
      mother-child-interaction at 5 to 6 months corrected age. We also hypothesize that reactivity
      of HPA axis and molecular patterns of stress signaling pathways differ in preterm infant with
      or without SSC after birth.
    


Intervention name(s): skin-to.skin-contact
Intervention type(s): Procedure
Intervention description(s): Immediately after initial stabilization/ assessment of the VLBW infant, skin-to-skin contact of mother and infant is initiated and kept up for 60 minutes.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: reactivity of HPA axis
Sleeper's and Adduction Stretch to Increase Shoulder ROM
Condition: Stiffness of Shoulder, Not Elsewhere Classified
Study type: Interventional

Summary: 
      The study aimed to compare the efficacy of modified sleeper stretch and modified cross-body
      adduction stretch in improving shoulder internal rotation range of motion and upper limb
      function. Thirty male lawn tennis players aged between 20 to 35, with more than 150
      glenohumeral internal rotation deficiency (GIRD) on the dominant shoulder (compared to the
      nondominant side) participate in the study and divided into two groups (A and B). Group A
      received a modified sleeper stretch and group B received a modified cross-body adduction
      stretch for four weeks, five times per week. The outcome measures were the internal rotation
      range of motion measured by a universal goniometer and upper limb functions measured by the
      Disability of the Arm, Shoulder, and Hand (DASH) scale.
    


Intervention name(s): Modified sleeper stretching; Modified cross-body adduction stretch
Intervention type(s): Other; Other
Intervention description(s): Modified sleeper stretching was performed on shoulder joint to increase internal rotation range of motion.; Modified cross-body adduction stretching was performed on shoulder joint to increase internal rotation range of motion.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Two-group two-factor research design was used.
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Sleeper Stretch; Cross-Body Stretch; Range of Motion; Shoulder; Tennis Players
A Trauma-Informed Approach for Positive Youth Development for Montana Students
Condition: Depression, Anxiety; Adolescent Behavior; Stress
MeSH terms: Depression
Study type: Interventional

Summary: 
      Given the prevalence of suicide and mental health issues in rural Montana, this project is
      intended to help mitigate stressors that may contribute to poor behavioral and mental health
      in high school-aged children. The immediate goal is to determine viability of a partnership
      with a rural southwestern Montana school and test the feasibility of a piloted implementation
      of a trauma-informed yoga intervention to address behavioral health outcomes and positive
      youth development.
    


Intervention name(s): Trauma-Informed Yoga
Intervention type(s): Behavioral
Intervention description(s): Trauma-Informed Yoga practice held within a high school weight training class
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Cardiometabolic Outcomes With Light Exposure During Sleep
Condition: Light
Study type: Interventional

Summary: 
      This study tested the hypothesis that acute exposure to light during nighttime sleep
      adversely affects cardiometabolic function.
    

Detailed description: 
      This study tested the hypothesis that acute exposure to light during sleep adversely affects
      next morning glucose homeostasis and whether this effect occurs via reduced sleep quality,
      melatonin suppression, or sympathetic nervous system (SNS) activation during sleep. Twenty
      young adults participated in this parallel-group study design. The room light condition
      (n=10) included one night of sleep in dim light (< 3 lux) followed by one night of sleep with
      overhead room lighting (100 lux). The dim light condition (n=10) included two consecutive
      nights of sleep in dim light.
    

Intervention name(s): room light
Intervention type(s): Behavioral
Intervention description(s): The room light condition (n=10) included one night of sleep in dim light (< 3 lux) followed by one night of sleep with overhead room lighting (100 lux). The dim light condition (n=10) included two consecutive nights of sleep in dim light.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: light; sleep; metabolism; sympathetic nervous system; insulin resistance
Evaluation of Efficacy and Patient Acceptance of Sound Amplifier Téo First, in Mild and Moderate Presbycusis Patient 60 Years of Age and Older, With no Previous Hearing Aid
Condition: Mild and Moderate Presbycusis
MeSH terms: Presbycusis
Study type: Interventional

Summary: 
      A personal sound amplifying device (PASP) like Teo First is a wearable electronic product
      that is not intended to compensate for impaired hearing, but rather is intended for
      non-hearing impaired consumers to amplify sounds in the environment for a number of reasons,
      such as for recreational activities. Nevertheless, a lot of mild and moderate impaired
      hearing people don't want to buy and wear all day a real hearing aid.

      The goal of our study is to evaluate the benefit of such a device for mild and moderate
      presbycusis patient 60 years of age and older, with no previous hearing aid.
    


Intervention name(s): Use of a personal sound amplifying device = TeoFirst
Intervention type(s): Device
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care