Micro-osteoperforations and Tooth Movement
Condition: Malocclusion
MeSH terms: Malocclusion
Study type: Interventional

Summary: 
      The purpose of this study is determine the effect the Microosteoperforation (MOPs) using the
      miniscrew on the rate tooth movement. Moreover, measurement of the level of the pain and
      pain's interference, the level of satisfaction and comfort using this protocol. Finally root
      resorption associate with this technique will be evaluated.
    

Detailed description: 
      This study will be randomized, split mouth design controlled trial with a 1:1 allocation
      ratio. One resident (A.A), calibrated by the main supervisor (S.M), will be reliable for
      recruiting the subjects, undertaking the orthodontic treatment under the supervision. The
      eligibility of the cases will be reevaluated by main supervisor (E.M) before the start of
      treatment.

      Split mouth design will be utilized with MOPs that will be randomly assigned to the patients'
      left or right sides to eliminate the possibility of uneven occlusal forces because of
      habitual occlusion predominantly on 1 side and also the eliminate the biological variability
      between subjects. The allocation sequence will be concealed from the researcher (A.A)
      enrolling and assessing participants in sequentially numbered, opaque, sealed and stapled
      envelopes with the participant's the name and date of birth are written before the
      intervention. Allocation concealment seeks to prevent selection bias, protects the assignment
      sequence until allocation.

      A Ethical approval will be granted by Jordan University of science and technology research
      center, and permission will be given at postgraduate dental clinics at Jordan University of
      science and technology, Irbid, Jordan.

      We hypothesized that 50% increased in rate of tooth movement in MOP group would produce a
      clinically significant difference. The sample size was calculated depend on a type I error
      frequency of 5%. According to the power analysis and assuming a large effect size difference
      between groups with 50% of acceleration rate of tooth movement, the power analysis yields a
      total sample size estimate of 44 samples at a conventional alpha-level (p = 0.05) and desired
      power (1 - β err prob) of 0.90, yielding 22 samples per group (means 22 patients that
      represent 22 MOP group and 22 Control group). Assuming an overall attrition rate of 15%,
      initial recruitment should target a total of 55 samples with 18 patients per group. All
      calculations were performed with the computer application G-Power (Erdfelder et al., 1996)
    

Intervention name(s): Micro-osteoperforation
Intervention type(s): Device
Intervention description(s): Three Micro-osteoperforation (MOPs) will be performed distal to canine by Mini screw. Before the application of the MOPs, Patient will be asked to wash their mouth twice by chorhexidine for 1 minute.
Other intervention name(s): Selective alveolar decortication
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Micro-Osteoperforation (MOPs); regional acceleratory phenomenon (RAP); Malocculsion