Can Latency of Action in Infraclavicular Brachial Plexus Block be Shortened With Warmed Bupivacaine?
Condition: Effect Increased
Study type: Interventional
Phase: Phase 1

Summary: 
      Brachial plexus blocks have some advantages, but also have some disadvantages as well. As
      with all nerve blocks, having to wait sometime for an effective block, sometimes failure to
      achieve an adequate block and possible requirement for isolated nerve block, having to wait a
      long time for resolution of the block, and immobilization of the extremity for some time can
      be seen as handicaps for brachial plexus block as well. In the present study, Study was aimed
      to compare the effects of bupivacaine warmed to body temperature and kept at room temperature
      on the onset time of ultrasound guided infraclavicular brachial plexus block.
    

Detailed description: 
      The study design was approved by the locale ethics committee. This double-blinded,
      randomized, controlled clinical trial recruited 60 patients aged between 18 and 65 years with
      the American society of anesthesiologists (ASA) physical status classification systems I/II
      and III who were candidated for surgical operations on any of the forearm, wrist and hand
      regions. All the participants were asked to sign an informed consent form after having been
      provided with details of the aim and proceedings of the study.

      Patients were excluded from the study if they had a neurological and neuromuscular disorders,
      psychiatric problems, cardiopulmonary diseases, coagulopathy, infections or allergy to local
      anesthetic agents.

      The patients were equally and randomly distributed into a 24C° 20 ml 0,5% bupivacaine group
      (Group 1), and 37C° 20 ml 0,5% bupivacaine group (Group 2) via closed envelope technique. All
      the participants were premedicated with 0.05 mg/kg of intravenous midazolam and monitored
      routinely before attempting nerve block.

      Bupivacaine stored for at least 2 hours in a bain-marie (Memmert Waterbath WNB7, Germany) at
      38˚C (regular temperature calibration was made) for Group 2.

      The block process was accomplished by an anesthesiologist, who was blind to the temperature
      of bupivacaine and local anesthetic agent was administered by different anesthesiologist.

      At the end of the ICBP block, an anesthetist blinded to the technique evaluated sensory and
      motor block in every minutes between 5th and 30th minutes as follows. The innervated areas
      (each dermatome) was evaluated using a pinprick test. The motor block was evaluated by
      bromage modified scale in every minutes between 10th and 30th minutes. Anxious patients were
      administered additional midazolam. Subjects refusing awake surgery were administered a
      propofol infusion with supplemental oxygen as necessary.
    

Intervention name(s): Bupivacaine Hydrochloride 5 MG/ML
Intervention type(s): Drug
Intervention description(s): Ultrasound guided infraclavicular brachial plexus block with warmed bupivacaine
Intervention MeSH terms: Bupivacaine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Bupivacaine; Brachial Plexus Block; Ultrasound