bioihbjkbjnl/mcl2 huggingface dataset:
Controlled Phonation and Vocal Rest Programs After Acute Vocal Exertion in Healthy Adults
Condition: Healthy
Study type: Interventional

Summary: 
      The proposed research will investigate the most effective strategy to reduce vocal exertion
      reported by speakers in noisy environments. Repeated vocal exertion can lead to voice
      problems and therefore identifying effective strategies can lead to better prevention of
      acquired voice disorders. This study will compare the effects of vocal rest and controlled
      phonation both before and after vocal exertion. The investigators hypothesize that vocal rest
      and controlled phonation will mitigate the negative effects of vocal exertion.
    


Intervention name(s): Vocal rest and Controlled Phonation
Intervention type(s): Behavioral
Intervention description(s): Voice rest and semi occluded vocal tract voice exercises
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Within Subject Design
Masking: None (Open Label)
Primary purpose: Treatment
Comparison of Salivary pH After Consuming Milk of Origin Vegetable vs Cow's Milk in Children
Condition: pH
Study type: Interventional

Summary: 
      The study was carried out in 21 first grade primary school children, 100% aged 6 years, 52.4%
      were female. They were given 5 types of milk, each one was measured on different days (Monday
      cow's milk, Tuesday coconut milk, Wednesday almond milk, Thursday soy milk, Friday rice milk)
    

Detailed description: 
      -  The study was carried out in 21 first grade primary school children, 100% aged 6 years,
           52.4% were female.

        -  The group was given a brushing technique using a model and 2 videos were shown to
           reinforce the brushing technique and explanation of what was going to be done in the
           study.

        -  Supervised tooth brushing was performed in a group of 5 people.

        -  They were given 5 types of milk, each one was measured on different days (Monday cow's
           milk, Tuesday coconut milk, Wednesday almond milk, Thursday soy milk, Friday rice milk).

        -  Each child was given 7 plastic cups each day and asked to pour their saliva into the cup
           when instructed.

        -  The samples were taken with pH indicator strips and the result was recorded in
           personalized tables.
    

Intervention name(s): Comparison of salivary pH after consuming milk of origin vegetable vs cow's milk
Intervention type(s): Dietary Supplement
Intervention description(s): They were given 5 types of milk, each one was measured on different days (Monday cow's milk, Tuesday coconut milk, Wednesday almond milk, Thursday soy milk, Friday rice milk).
Other intervention name(s): cow´s milk, coconut milk, almond milk, soy milk and rice milk
Intervention model: Single Group Assignment
Intervention model description: The study was carried out in 21 first grade primary school children, they were given 5 types of milk, each one was measured on different days (Monday cow's milk, Tuesday coconut milk, Wednesday almond milk, Thursday soy milk, Friday rice milk).
Masking: None (Open Label)
Primary purpose: Other
Language Treatment for Progressive Aphasia
Condition: Primary Progressive Aphasia; Nonfluent Progressive Aphasia; Semantic Dementia
MeSH terms: Dementia; Aphasia; Aphasia, Primary Progressive; Pick Disease of the Brain; Frontotemporal Dementia
Study type: Interventional

Summary: 
      Progressive aphasia is characterized by a steady and progressive loss of language skills in
      the presence of relatively preserved memory, attention, and thinking. The aim of this study
      is to slow the progression of language decline in progressive aphasia via language therapy.
      The first goal of this study is to improve naming abilities of individuals with progressive
      aphasia. This will be accomplished by carrying out an intensive treatment program for anomia.
      The second goal is to evaluate whether this intense language treatment re-activates affected
      areas and/or connections within the language network, using functional Magnetic Resonance
      Imaging (to measure neural activity in specific brain regions) and Diffusion Tensor Imaging
      tractography (to measure the connectivity between specific brain regions). This is the first
      study on progressive aphasia addressing both treatment and imaging in the same patients.
    


Intervention name(s): Errorless learning
Intervention type(s): Behavioral
Intervention description(s): Language testing,20 sessions of language therapy, and 2 neuroimaging sessions for participants with progressive aphasia Language testing and 1 imaging session for healthy controls
Other intervention name(s): treatment for anomia
Intervention model: Single Group Assignment
Masking: None (Open Label)
Keywords: progressive aphasia; semantic dementia; neuroimaging; treatment; errorless learning
Comparison of the Efficacy of Inflexal V With a Commercially Available Influenza Vaccine in Young Children
Condition: Influenza
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 3

Summary: 
      A study to assess whether the Northern Hemisphere 2009/2010 season influenza vaccine Inflexal
      V is as immunogenic as a locally sourced competitor vaccine in young children.
    


Intervention name(s): Inflexal V; Inflexal V; Agrippal
Intervention type(s): Biological; Biological; Biological
Intervention description(s): Inflexal V influenza vaccine, formulated for the WHO requirements of the 2009-2010 season, containing per 0.5 mL dose:
15 µg hemagglutinin (HA) antigen of A/Brisbane/59/2007 (H1N1)-like virus
15 µg HA antigen of A/Brisbane/10/2007 (H3N2)-like virus
15 µg HA antigen of B/Brisbane/60/2008-like virus
Dose: intramuscular administration (M. deltoideus) of a single dose of 0.5 mL on Days 0 and 28; Inflexal V influenza vaccine, formulated for the WHO requirements of the 2009-2010 season, containing per 0.5 mL dose:
15 µg HA antigen of A/Brisbane/59/2007 (H1N1)-like virus
15 µg HA antigen of A/Brisbane/10/2007 (H3N2)-like virus
15 µg HA antigen of B/Brisbane/60/2008-like virus
Dose: intramuscular administration (M. deltoideus) of a single dose of 0.25 mL on Days 0 and 28; Agrippal influenza vaccine
Dose: intramuscular administration (M. deltoideus) of a single dose of 0.25 mL on Days 0 and 28
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Influenza; Virus; Vaccination; Immunisation
Groin Injuries in Finnish Contact Sports
Condition: Groin Injury
MeSH terms: Wounds and Injuries
Study type: Observational

Summary: 
      The prevalence of acute and chronic groin injuries in athletes is between 5 and 10 %. This
      observational case-control study follows three contact sport teams (soccer, ice-hockey and
      bandy) for two years to find out the prevalence and reasons for groin pain. Clinical
      examination, pain scores and pelvic magnetic resonance imaging (MRI) are performed. Hip and
      groin questionnaire (HAGOS) is used to determine severity of groin injuries.
    

Detailed description: 
      The prevalence of chronic groin pain in athletes and physically active adults is between 5
      and 10 %. Common causes include adductor tendonitis, musculus rectus abdominis tendopathy,
      osteitis pubis (edema on MRI scans at pubic symphysis) or disruption of the posterior wall of
      inguinal canal or iliopsoas muscle. This observational case-control study follows three
      contact sports team (male soccer, ice-hockey and bandy) for two years to find out prevalence
      of acute and chronic groin pain. Adult (>18 years old) male athletes with acute or chronic
      groin pain during the study pediod are included. Outcome measures are clinical examination,
      pain scores, exact diagnosis and repeated pelvic MRI (two times) are performed in each
      patients and three control atheletes in each team. Hip and groin questionnaire (HAGOS) is
      used to determine the severity of groin injuries. The end-points of study are prevalence of
      groin injuries and exact diagnosis.
    

Intervention name(s): magnetic resonance imaging
Intervention type(s): Device
Intervention description(s): to diagonose groin injury exactly in magnetic resonance imaging
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        three contact sport teams (male ice-hockey, soccer, bandy)
      
Keywords: groin pain, groin injury, magnetic resonance imaging
A Study to Assess Bioquivalence Between a Novel Naproxen Sodium 275 mg Film-coated Tablet and Nalgesin Naproxen Sodium 275 mg Film-coated Tablet in Healthy Adult Volunteers
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a research study designed to evaluate the rate and extent of absorption of Naproxen
      from a novel Naproxen sodium tablet and Nalgesin naproxen sodium 275 mg.
    

Detailed description: 
      The study has an open-label, randomized, two-way crossover design. 28 healthy participants
      will be included. Single-doses of 1 tablet of Naproxen sodium 275 mg and Nalgesin 275 mg will
      be given on separate treatment visits to healthy adult participants under fasting conditions.
      A crossover design is chosen in order to allow within-subject comparisons of treatments. To
      minimize the risk of carry-over effect, the washout period between the study drug
      administrations is set to 7 days. The study is open-label because the primary data collected
      are concentration measurements that cannot be expected to be affected by a participant's
      knowledge of the product administered.
    

Intervention name(s): Naproxen sodium (test product); Naproxen sodium (reference product)
Intervention type(s): Drug; Drug
Intervention description(s): Participants will be administered single doses of 275 mg Naproxen sodium (test product) tablet orally.; Participants will be administered single doses of 275 mg Naproxen sodium (reference product - Nalgesin) tablet orally.
Other intervention name(s): Nalgesin
Intervention MeSH terms: Naproxen
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Bioequivalence
Effects of Electromagnetic Therapy Versus Laser Therapy on Peripheral Diabetic Neuropathy
Condition: Diabetes
Study type: Interventional
Phase: Phase 2

Summary: 
      This study are to:

        -  Evaluate effect of magnetic therapy on peripheral neuropathy in diabetic patients.

        -  Evaluate effect of laser therapy on peripheral neuropathy in diabetic patients.

        -  Compare effects of magnetic therapy with that of laser therapy on peripheral neuropathy
           in diabetic patients.
    

Detailed description: 
      Sixty- five male and female diabetic patients with peripheral neuropathy will be selected to
      participate in this study. They will be equally divided into two groups Group-I: Twenty five
      patient with diabetic peripheral neuropathy will be exposed to low intensity pulsed magnetic
      therapy Group-II: Twenty five patients with diabetic peripheral neuropathy will be exposed
      for 24 treatment sessions of laser therapy Group-III 15 patient received only medical
      treatment
    

Intervention name(s): Magnetic therapy; laser therapy; Only medical treatment
Intervention type(s): Device; Device; Drug
Intervention description(s): low intensity pulsed magnetic therapy with a frequency of 200 Hertz and intensity of 50 Gauss . Magnetic device will be applied on each patient from a comfortable supine lying position. After the connection of appliance to electrical supply, the actions of PEMF will be directed and adjusted over lumbar spine, hip regions and calf muscles of both lower limbs.; laser therapy of Helium neon infrared laser (850 nano-meter) was used in continuous wave mode from a comfortable prone lying position on the whole plantar surface of the foot and the lumbo-sacral area by four points, and two points laterally to the spine.; Fifteen patients with diabetic peripheral neuropathy were treated with antidiabtic drugs and lyrica 150 milligram daily
Other intervention name(s): Lyrica 150 milligram
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Neuropathies laser and magnetic therapy
Oral Dydrogesterone (OD) Versus Micronized Vaginal Progesterone (MVP) for Luteal Phase Support (LPS) in IVF/ICSI
Condition: Infertility, Female; Infertility; Genital Diseases, Male; Genital Diseases, Female; Progesterone; Dydrogesterone; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Physiological Effects of Drugs; Progestins
MeSH terms: Infertility; Infertility, Female; Genital Diseases; Genital Diseases, Male; Genital Diseases, Female
Study type: Interventional
Phase: Phase 4

Summary: 
      Female inability to conceive a child. The purpose of this prospective randomized,
      double-blinded, double dummy, two-arm cross-over study is to investigate the difference on
      histological, transcriptional and immunological level in endometrium between 3x10mg
      Dydrogesterone oral tablets and 3x200 mg Micronized progesterone intravaginal capsules for
      the luteal support in egg cell donors. Beside that, the pharmacokinetics, the impact on the
      peripheral immunology (by blood sampling) and the microbiota (by genital swabs) will be
      investigated.
    


Intervention name(s): Dydrogesterone Oral Tablet; Micronized progesterone; Placebo Dydrogesterone oral tablet; Placebo Micronized progesterone
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Tablet, oral, 10 mg, 3 times daily, starting on the day of oocyte retrieval in the morning and during 8 days; Capsule, vaginal, 200 mg, 3 times daily, starting on the day of oocyte retrieval in the morning and during 8 days; Tablet, indistinguishable from dydrogesterone oral tablet; Capsule, indistinguishable from micronized vaginal progesterone capsules
Other intervention name(s): OD; Duphaston; MVP; Utrogestan; Placebo OD; Placebo MVP
Intervention MeSH terms: Progesterone; Dydrogesterone
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: A randomised, cross-over, double blind double dummy study
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN3918 in Healthy Volunteers
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      To evaluate the safety and tolerability of single ascending intravenous (IV) and subcutaneous
      (SC) doses and a multiple dose regimen.
    

Detailed description: 
      Participants will be randomized to single IV or SC or multiple dose treatment with REGN3918
      or matched placebo.
    

Intervention name(s): REGN3918; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Intravenous (IV) or Subcutaneous (SC); Matching Placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Safety and Efficacy Study in Subjects With Diabetic Neuropathic Pain
Condition: Diabetic Neuralgia; Diabetic Neuropathies; Diabetic Neuropathy, Painful; Diabetic Polyneuropathy; Neuralgia, Diabetic
MeSH terms: Peripheral Nervous System Diseases; Neuralgia; Diabetic Neuropathies; Polyneuropathies
Study type: Interventional
Phase: Phase 2

Summary: 
      This study will compare the efficacy and the safety of ABT-894 (1mg, 2mg or 4mg capsules)
      administered BID to placebo in the treatment of DNP. Another treatment arm will be Duloxetine
      60mg administered once daily (QD). Approximately 275 subjects will be enrolled into the study
      at approximately 50 sites in both the United States and Europe. The study will be divided
      into the following periods: Screening/Washout (21 days) followed by a Baseline Visit, an
      8-week Treatment Period and a 1-week Follow-up Visit.
    


Intervention name(s): ABT-894; ABT-894; ABT-894; placebo; Duloxetine
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): ABT-894 1 mg capsule BID throughout treatment period; ABT-894 2 mg capsule BID throughout treatment period; ABT-894 4 mg capsule BID throughout treatment period; placebo capsule BID throughout the treatment period; Duloxetine 60 mg QD throughout treatment period
Intervention MeSH terms: Duloxetine Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Diabetic Neuropathy; Painful; Diabetic Polyneuropathy; Neuralgia; Diabetic; Diabetic Neuropathies; Diabetic Neuralgia
Compare Pharmaceutical Economics and Efficacy of Sevoflurane With Low Fresh Gas Flow Balanced Anesthesia, Propofol Target Controlled Infusion Anesthesia and Propofol Induction Sevoflurane Maintenance Anesthesia
Condition: Elective Laparoscopic Surgery
Study type: Interventional
Phase: Phase 4

Summary: 
      This study is being performed to compare the cost of anesthetic techniques with sevoflurane
      (low fresh gas flow balanced anesthesia) versus propofol (target controlled infusion [TCI])
      versus propofol induction and sevoflurane maintenance anesthesia in subjects undergoing
      elective laparoscopic surgery with predicted anesthesic use between 1 and 3 hour duration.
    

Detailed description: 
      Three hundred thirty-six subjects were enrolled in this study. Two subjects, one treated with
      propofol for induction and maintenance and one treated with propofol for induction and
      sevoflurane for maintenance are not included in the study participation since no information
      was available for these two subjects.
    

Intervention name(s): Sevoflurane Inhalational Induction and Maintenance; Propofol Target Controlled Infusion for Induction and Maintenance; Propofol Target Controlled Infusion for Induction and Sevoflurane Inhalation for Maintenance
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Sevoflurane was administered at a concentration of 8% via vital capacity induction and sevoflurane 0.8-1.5 minimum alveolar concentration (MAC) with a rate of 1 L/min fresh gas flow for maintenance.; Propofol IV 4 ug/mL was administered with target controlled infusion (TCI) for induction and propofol 3 to 6 ug/mL was administered with TCI for maintenance.; Propofol was administered as a bolus IV dose of 1.5 mg/kg for induction at a rate of 40 mg/10 seconds. During maintenance, a sevoflurane concentration of 0.8-1.5 minimal alveolar concentration (MAC) was administered at a rate of 1 L/min fresh gas flow.
Other intervention name(s): ABT-941; sevoflurane; Ultane; Sevorane; Sevofrane; Propofol; ABT-941; sevoflurane; Ultane; Sevorane; Sevofrane
Intervention MeSH terms: Propofol; Sevoflurane
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Sevoflurane; Propofol; Economics; Pharmaceutical; Chinese
β Blocker Use and Mortality in Hospital Survivors of Acute Myocardial Infarction Without Heart Failure
Condition: Acute Myocardial Infarction
MeSH terms: Heart Failure; Myocardial Infarction; Infarction
Study type: Observational [Patient Registry]

Summary: 
      The aim of the study is to investigate the association between the use of β blockers and
      mortality among hospital survivors of acute myocardial infarction without heart failure.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The study population comprised of 179,810 in hospital survivors of acute myocardial
        infarction without heart failure recorded in the Myocardial Ischaemia National Audit
        Project registry between 2007 and June 2013
      
Keywords: Acute myocardial infarction; mortality; evidence-based care; Myocardial Ischaemia National Audit Project; β blockers
Effects of Diet-induced Weight Loss in Obese Men
Condition: Sexual Dysfunction; Endothelial Dysfunction; Quality of Life; Inflammation
MeSH terms: Inflammation; Weight Loss
Study type: Interventional
Phase: Phase 4

Summary: 
      This study aims to compare the efficacy of a partial meal replacement diet with a
      conventional diet, for inducing weight loss and improving metabolic and inflammatory profile,
      endothelial function, erectile function, sexual desire, lower urinary tract symptoms (LUTS),
      and quality of life in obese men.
    

Detailed description: 
      This study aims to compare the efficacy of a partial meal replacement diet with a
      conventional diet, for inducing weight loss, and improving metabolic and inflammatory
      profile, endothelial function, erectile function, sexual desire, lower urinary tract symptoms
      (LUTS), and quality of life in obese men. Men aged 30-65 years, with body mass index (BMI) ≥
      27.5 kg/m2, will be recruited from the community in Singapore. The study will be conducted at
      Changi General Hospital by trained medical investigators, dieticians and sports trainers. At
      baseline and 12 weeks, fasting glucose and lipids, insulin, testosterone, sex-hormone binding
      globulin, serum C-reactive protein and interleukin-6 are measured, endothelial function is
      measured by the non-invasive EndoPAT method, and validated questionnaires administered to
      assess changes in erectile function, sexual desire, LUTS and quality of life
    

Intervention name(s): Optifast; Conventional diet counseling
Intervention type(s): Dietary Supplement; Behavioral
Intervention description(s): 1-2 sachets of Optifast daily as part of diet modification (partial meal replacement diet)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: obesity; men; sexual function; urinary tract symptoms; endothelial function; inflammation; quality of life
Study Evaluating BLI-489 and Piperacillin in Healthy Subjects
Condition: Healthy Subjects
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate how BLI-489 and piperacillin interact when given
      together to healthy subjects.
    


Intervention name(s): BLI-489/Piperacillin; BLI-489; Piperacillin
Intervention type(s): Drug; Drug; Drug
Intervention MeSH terms: Piperacillin; BLI-489
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment