The Presence Of Sarcopenia In Patients With Knee Osteoarthritis
Condition: Sarcopenia; Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee; Sarcopenia
Study type: Observational

Summary: 
      Osteoarthritis (OA) is one of the most common joint disorders worldwide . The knee is the
      most common symptomatic joint in osteoarthritis. In this study, we evaluated the presence of
      sarcopenia multidimensionally in patients with knee osteoarthritis (OA) using clinical,
      ultrasonographic and biochemical parameters, and in this respect, it was aimed to investigate
      the relation between OA and sarcopenia and to identify the most practical, easily accessible
      and inexpensive method for investigating sarcopenia.
    

Detailed description: 
      102 patients with clinical and radiological diagnosis of knee osteoarthritis and 33 healthy
      control subjects were included in the study. A total of 135 subjects were evaluated using the
      European Working Group on Sarcopenia in Older People (EWGSOP) diagnostic criteria of
      sarcopenia. The first group consists of (OA) patients with sarcopenia, the second group
      consist of OA patients without sarcopenia and the third group is controls subjects. The
      detailed musculoskeletal system examination of the patients included in the study was carried
      out by a single physician, and complete blood count, renal function tests, electrolytes,
      total protein, albumin, 25 (OH) vitamin D, serum leptin, serum adiponectin, PTH, TSH and
      vitamin B12 values were recorded using the venous blood samples taken from the study
      group.Dual-X-ray absorptiometry (DEXA) is used to measure Body composition parameters and
      muscle mass measurements, isometric muscle strength evaluations, handgrip strength and gait
      speeds for diagnosis of sarcopenia. Short-form -36 (SF-36) The Nutritional Assessment-short
      form (MNA), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the
      International Physical Assessment Questionnaire Short Form (IPAQ-SF) and the Center for
      Epidemiologic Studies Depression Scale (CES-D scale) were administered to every patient as
      outcome measures.
    

Intervention name(s): Musculoskeletal ultrasound; Dual-X-ray absorptiometry; Isokinetic dynamometer
Intervention type(s): Diagnostic Test; Diagnostic Test; Diagnostic Test
Intervention description(s): The ultrasonographic assesment will be used to examine the rectus femoris, gastrocnemius medailalis and rectus abdominis subcutaneous and muscle thickness. Additionally, fascicle length and pennation angle were measured between the two parallel aponeuroses of the gastrocnemius muscle (bulkiest part of medial head) in the longitudinal view when subjects were in prone position with their ankles at 90°.; The muscle masses of the patients were evaluated by measuring the fat mass (Fat Mass-FM), fat mass index (FMI), lean body mass (LBM) and skeletal muscle index (SMI) calculated by DEXA. Appendicular muscle mass (ASM) is calculated by summing the lean soft tissue of the two upper limbs and the two lower limbs. Skeletal muscle mass index is calculated by dividing the appendicular lean mass by the square of the neck height [SMI = ASM / height2 (kg / m2)].; Quadriceps-hamstring Peak Torque (PT) values and the ratio of PT values to body weight (PT / VA) (at 60 and 180 ° / sec speeds) were evaluated with an isokinetic dynamometer
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        A total of 102 patients ages 50 to 70 years were diagnosed with knee osteoarthritis
        according to the American College of Rheumatology criteria and 33 healthy volunteers were
        enrolled in this study.
      
Keywords: Dual-X-ray absorptiometry; Sarcopenia; Knee osteoarthritis; ultrasonography