bioihbjkbjnl/mcl2 huggingface dataset:
Effect of Elastic Bandage on Balance in Chronic Ankle Instability
Condition: Ankle Sprain
MeSH terms: Ankle Injuries
Study type: Interventional

Summary: 
      Purpose: To report the immediate and prolonged (one week) effects of elastic bandage on
      balance control in subjects with chronic ankle instability.

      Material and methods: Twenty-eight individuals successfully completed the study protocol, of
      whom 14 were randomly assigned to the elastic bandage group (7 men, 7 women) and 14 were
      assigned to the non-standardized tape group ( 9 men, 5 women). To objectively measure
      postural sway we used computerized dynamic posturography with Sensory Organization Test and
      Unilateral Stance test. We analyzed the following Sensory Organization Test parameters: the
      composite Sensory Organization Test score, the composite Sensory Organization Test strategy
      and the Sensory Organization Test condition 2 and its strategy. In addition, we studied the
      centre of gravity sway velocity with open eyes and close eyes during the US test.
    


Intervention name(s): Elastic Bandage (Idealplast C®); Pretape cramer® (non standarized tape)
Intervention type(s): Device; Device
Intervention description(s): Elastic bandage
One anchor strip is applied around the ankle with no tension applied to the tape to avoid restricting blood flow. A supporting stirrup strap is applied from the inside of the ankle, under the heel with no tension up to this point. As the tape is passed up the outside of the ankle tension is applied to the tape with the foot in slight dorsiflexion and secured to the anchor strap (black arrow).
For heel lock, a second strip is applied on the outside of the ankle, taken across the front of the ankle and just above the bony part on the inside of the ankle and back towards the heel (red arrow). Then taken around and under the heel back the way you have just come and around the front of the ankle (orange arrow). The tape then passes above the bony part of the ankle on the outside and diagonally towards the heel, across to the inside of the ankle then around the top to finish; Pretape cramer® was used.
The individual is in supine position keeping the foot and ankle in a neutral position.
The strip (I) is applied with not stretch in the outside of the leg just above the ankle, and then the rest of the strip is applied on the outside of the ankle and under the heel.
This is the only intervention carried out in this group.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Adhesive elastic bandaging; balance; posturography
Genetic Predisposition for Chronic Non-specific Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain; Disease Susceptibility; Genetic Predisposition to Disease
Study type: Observational

Summary: 
      Patients with inflammatory back pain were shown to differ from healthy controls in genotype
      of the Angiotensin-converting enzyme (ACE), which regulates vasoconstriction/-dilatation. The
      aim of this study is to investigate whether genetic reduction of muscle perfusion might be a
      pathophysiological pathway of how genes influence chronic non-specific low back pain (LBP).
    

Detailed description: 
      The following genes will be investigated:

        -  Insertions-/deletions-polymorphism of the angiotensin-converting enzyme (ACE-I/D gene
           polymorphism; 3 genotypes: ACE-II, ACE-ID, ACE-DD).

        -  Anti-adhesive extracellular matrix protein Tenascin-C: gene polymorphism rs2104772

      The goals of this study are to investigate whether these genotypes correlate with 1)
      endurance of back muscles, 2) comorbidities such as asthma and diabetes and 3) the risk for
      LBP as assessed by a LBP-classification tool.
    

Intervention name(s): no intervention
Intervention type(s): Other
Intervention description(s): observational case-control study
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Patients with chronic low back pain and healthy controls without low back pain.
Plasma and Urine TMAO Formation and Changes to Oxidized LDL After Ingestion of Different Amounts of Egg
Condition: Biomarkers of Cardiovascular Disease
MeSH terms: Cardiovascular Diseases
Study type: Interventional

Summary: 
      Eggs contain an essential nutrient called choline and adequate levels of choline are required
      for good health. Studies in mice have demonstrated that high levels of choline may increase
      risk of heart disease through a process that involves the breakdown of choline by gut
      bacteria. Previous research did not show that human consumption of eggs increases risk of
      heart disease. This study is designed to investigate whether the number of eggs in the diet
      affects blood and urine markers for heart disease.
    

Detailed description: 
      Diets low in choline have adverse health consequences, while observations in humans and
      experiments in mouse models suggest that a diet containing too much choline or
      phosphatidylcholine may activate inflammatory pathways and increase cardiovascular disease
      risk through bacterial conversion of choline to trimethylamine (TMA) and its subsequent
      oxidation to trimethylamine N-oxide (TMAO) in the liver. What is unclear is whether choline
      and phosphatidylcholine in eggs is a source of TMAO formation, and if so how many eggs must
      be eaten before enough TMAO is generated to cause increased oxidized LDL (a biomarker for
      atherosclerosis mechanisms). We hypothesize that TMAO will only be formed from eggs when very
      large quantities are ingested and that TMAO formation will vary greatly between individuals
      for any given dietary exposure. This variability will be determined by 1) the dose at which
      dietary choline or phosphatidylcholine exceeds the absorptive capacity of the volunteer's
      small intestine and therefore spills into large intestine where gut bacteria have access to
      it and 2) the bacterial populations that constitute the volunteer's microbiome.
    

Intervention name(s): Egg Dose
Intervention type(s): Other
Intervention description(s): Different quantities of eggs
Intervention model: Single Group Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Immunopathogenesis of Chlamydia
Condition: CHLAMYDIA INFECTIONS
MeSH terms: Infections; Chlamydia Infections
Study type: Observational

Summary: 
      Sexually transmitted Chlamydia trachomatis infections are a widespread public health concern
      due to their prevalence and potentially devastating reproductive consequences, including
      pelvic inflammatory disease, infertility, and ectopic pregnancy. The goal of this study is to
      evaluate the risk factors for adverse outcomes following genital tract infection with
      Chlamydia trachomatis and to evaluate whether or not the presence of C. trachomatis in the
      rectum act as a reservoir for infection.
    

Detailed description: 
      Sexually transmitted Chlamydia trachomatis infections are a widespread public health concern
      due to their prevalence and potentially devastating reproductive consequences, including
      pelvic inflammatory disease, infertility, and ectopic pregnancy. The goal of this study is to
      evaluate the risk factors for adverse outcomes following genital tract infection with
      Chlamydia trachomatis and to evaluate whether or not the presence of C. trachomatis in the
      rectum act as a reservoir for infection. Our target population will be adolescent females age
      11-21 evaluated at the ACH Adolescent Center who are undergoing pelvic examinations or urine
      screening for sexually transmitted infections (STIs). Laboratory specimens obtained will
      include cervical and rectal swabs, urine and blood specimens, as well as, chart review and
      comprehensive subject interviews in the initial data collection with follow-up evaluations at
      3, 6, 12, 24 and 36 months for qualifying subjects
    

Intervention name(s): No intervention, only observational
Intervention type(s): Other
Intervention description(s): No intervention, only observational
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Adolescent females between 11 and 21 years of age undergoing pelvic examinations or
        screening for STIs at the Arkansas Children's Hospital Adolescent Center will be eligible
        for recruitment
      
Biospecimen description: 
      Endocervical or vaginal swabs, rectal swabs, blood (whole and serum),urine
    
Keywords: Chlamydia; Chlamydia trachomatis; Adolescent Health; Female Health; Sexually Transmitted Infections; Infertility; Pelvic Inflammatory Disease
Clinical Trial of SB-509-0401 in Subjects With Diabetic Neuropathy
Condition: Diabetic Neuropathy
MeSH terms: Peripheral Nervous System Diseases; Diabetic Neuropathies
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the clinical and laboratory safety of SB-509 when
      given as a single treatment by an intramuscular injection to subjects with diabetic
      neuropathy.
    

Detailed description: 
      Primary objective:

      To evaluate the clinical and laboratory safety of SB-509 when given as a single treatment by
      an intramuscular injection. To determine the maximum tolerated dose (MTD) of a single
      treatment by intramuscular injection by SB-509.

      Secondary objective:

      To evaluate the lower extremity clinical effects of SB-509 treatment on lower limb diabetic
      neuropathy by symptoms, neurological examination, and lower extremity electrophysiological
      testing.
    

Intervention name(s): hVEGF-A
Intervention type(s): Genetic
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: Single
Primary purpose: Treatment
Keywords: Diabetes; Neuropathy
Clinical Performance of Two Daily Disposable Silicone Hydrogel Contact Lenses
Condition: Visual Acuity
Study type: Interventional

Summary: 
      This is a subject-masked, randomized, bilateral, 2x2 crossover clinical investigation that
      will assess lens fit acceptance.
    


Intervention name(s): Acuvue® Oasys MAX 1-Day; Dailies Total 1
Intervention type(s): Device; Device
Intervention description(s): TEST Lens; CONTROL Lens
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Treatment
A Phase I Safety and Immunogenicity Trial of Live Recombinant Canarypox ALVAC-HIV vCP300 and HIV-1 SF-2 rgp120 in HIV-1 Uninfected Adult Volunteers
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      To evaluate, in HIV-negative volunteers, the safety and immunogenicity of ALVAC-HIV
      MN120TMGNP (vCP300) followed by or combined with boosting using rgp120/HIV-1SF2. To compare
      ALVAC-HIV vCP300 with ALVAC-RG rabies glycoprotein (vCP65) as a control. To evaluate an
      accelerated immunization schedule at 0, 1, 3, and 6 months versus 0, 1, 6, and 9 months.

      The combination of a live recombinant primer followed by a subunit boost has the potential to
      induce not only cytotoxic T lymphocytes but also neutralizing antibody.
    

Detailed description: 
      The combination of a live recombinant primer followed by a subunit boost has the potential to
      induce not only cytotoxic T lymphocytes but also neutralizing antibody.

      Volunteers are randomized to one of seven groups to receive immunizations with either
      ALVAC-HIV vCP300 or ALVAC-RG vCP65 (control), plus simultaneous or sequential boosting with
      rgp120/HIV-1SF2 or placebo. Immunizations are given at 0, 1, 6, and 9 months or 0, 1, 3, and
      6 months. Volunteers are followed for at least 24 months.
    

Intervention name(s): ALVAC-HIV MN120TMGNP (vCP300); ALVAC-RG Rabies Glycoprotein (vCP65); rgp120/HIV-1 SF-2
Intervention type(s): Biological; Biological; Biological
Intervention MeSH terms: polysaccharide-K
Masking: Double
Primary purpose: Prevention
Keywords: Vaccines, Synthetic; HIV Envelope Protein gp120; AIDS Vaccines; HIV Seronegativity; Avipoxvirus; HIV Preventive Vaccine
Study Describing the Hypertensive Population Treated With Telmisartan and Conditions of Use by Medical Practitioners and Patients
Condition: Hypertension
MeSH terms: Hypertension
Study type: Observational

Summary: 
      Primary objective: to characterize hypertensive patients treated for at least 1 month with
      Telmisartan (alone or in combination with other drugs) in order to define the beneficiary
      population (those actually receiving the treatment).

      Secondary objectives:

        -  to describe the patients' blood pressure values (when self-monitored) and satisfaction
           with the treatment (ease of use, efficacy, safety) on the basis of a patient
           self-questionnaire, filled out 4 weeks after consultation.

        -  to compare the characteristics of the beneficiary population to those of the initial
           target population defined in the SPC (summary of product characteristics) for
           Telmisartan
    


Intervention name(s): Telmisartan
Intervention type(s): Drug
Intervention MeSH terms: Telmisartan
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Hypertensive patients treated with Telmisartan for at least one month recruited by ceneral
        practitioners and cardiologists
A Study to Evaluate Potential Cytochrome P450 and Transporter Protein Interactions With CC-99677
Condition: Healthy Volunteer
Study type: Interventional
Phase: Phase 1

Summary: 
      It is a phase 1, open-label, single-center, three-part study to assess the safety,
      tolerability, and pharmacokinetics of multiple doses of CC-99677 administered alone or in
      combination with either methotrexate and sulfasalazine; itraconazole, rifampin, midazolam, or
      a cocktail of digoxin, metformin, and rosuvastatin in healthy subjects
    

Detailed description: 
      This study will allow investigation of potential drug-drug interaction mediated through
      cytochrome P450 enzymes and drug transporter proteins. During each part, blood samples will
      be collected at prespecified times for pharmacokinetic assessments. Subject safety will be
      monitored throughout the study. There will be approximately 16 subjects enrolled into each
      part.
    

Intervention name(s): CC-99677; Methotrexate; Sulfasalazine; Itraconazole; Rifampin; Midazolam; Digoxin; Metformin; Rosuvastatin
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): CC-99677; Methotrexate; Sulfasalazine; Itraconazole; Rifampin; Midazolam; Digoxin; Metformin; Rosuvastatin
Intervention MeSH terms: Metformin; Itraconazole; Rifampin; Sulfasalazine; Methotrexate; Digoxin; Midazolam; Rosuvastatin Calcium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Healthy Volunteer; Pharmacokinetics; Safety Tolerability; CC-99677
Role of Mineralocorticoid Receptor in Diabetic Cardiovascular Disease
Condition: Type 2 Diabetes Mellitus; Vascular Disease
MeSH terms: Cardiovascular Diseases; Vascular Diseases; Diabetes Mellitus, Type 2
Study type: Interventional

Summary: 
      Aldosterone is a significant mediator of cardiovascular injury associated with heart failure
      and the cardiovascular benefits of mineralocorticoid receptor blockade are additive to those
      of angiotensin converting enzyme inhibitors or angiotensin II (ANGII) receptor blockers. This
      study will test the hypothesis that mineralocorticoid receptor (MR) antagonists exert
      beneficial cardiovascular effects, specifically by decreasing vascular injury and improving
      vascular function. A randomized, double-blind study will be conducted, in which participants
      with Type 2 Diabetes Mellitus will undergo a series of assessments to test heart, blood
      vessel, and kidney function at baseline, and after 2 and 6 months of treatment with one of
      the following drugs:

        1. spironolactone

        2. hydrochlorothiazide (HCTZ) plus potassium

        3. placebo

      In the event of insufficient funds, randomization to the placebo arm will be stopped and
      primary assessment of outcomes will occur at baseline and after 6 months of treatment.
    


Intervention name(s): Spironolactone; Hydrochlorothiazide + potassium; Placebo
Intervention type(s): Drug; Drug; Other
Intervention description(s): 25 mg capsule daily for 6 months; hydrochlorothiazide (HCTZ) + potassium, 12.5 mg/10 milliequivalents (mEq) capsule daily; Placebo capsule daily
Intervention MeSH terms: Hydrochlorothiazide; Spironolactone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Structural and Functional Changes in Supraspinatus Tendinopathy Thtough Percutaneous Electrolysis and Neuromodulation Combined Therapy. A Single-blinded Randomized clínical Trial.
Condition: Supraspinatus Tendinitis
MeSH terms: Tendinopathy
Study type: Interventional

Summary: 
      The supraspinatus muscle tendinopathy show a big impact, however, there is a lack of
      awareness about the options of the physiotherapist treatment. It is necessary to do studies
      about effectiveness of therapeutic percutaneous electrolysis and neuromodulation. This
      technique enables treatment of the tendinopathies. To analyze the effectiveness of
      therapeutic percutaneou electrolysis and neuromodulation in the treatment of supraspinatus
      muscle tendinopathy. Single center randomized controlled trial, parallel treatment design. A
      specialist physician will be diagnosed the supraspinatus muscle tendinopathy. Participants
      will be randomly assigned to receive treatmen for 4 weeks: percutaneou electrolysis and
      neuromodulation associated with eccentric exercises or conventional treatment of
      Physiotherapy with the same eccentric exercises. Both interventions were performed under
      ultrasound guidance with a portable ultrasound (General Electric LogicE). Data will be
      collected by a blinded evaluator.
    

Detailed description: 
      Eccentric exercises of the supraspinatus muscle were performed in 3 sets of 10 repetitions.
      Participants were asked to perform the exercise program on an individual basis twice every
      day for 4 weeks. The eccentric program consisted of 3 exercises, focusing on the
      supraspinatus, infraspinatus, and scapular muscles. Participants were asked to do a normal
      abduction (concentric phase) and a slow return to the initial position (eccentric phase)
      included first the concentric phase, and the eccentric phase was slowly conducted. The
      exercise program was taught by a physiotherapist in the first session and monitored in the
      subsequent sessions.
    

Intervention name(s): Experimental Group; Conventional group
Intervention type(s): Other; Other
Intervention description(s): Therapeutic Percutaneous Electrolysis an neuromodulation associated with eccentric exercises devices at home.; Ultrasound pulsatil therapy (US), transcutaneous electric nerve stimulation (TENS) for 20 minutes and associated with eccentric exercises devices at home.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A specialist physician will be diagnosed the supraspinatus tendinopathy.
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: tendinopathy; electrolysis; exercise; dry needling; physiotherapy
Evaluation of Patellar Dimension and Bristol Index in Asian Population
Condition: Patello Femoral Syndrome
MeSH terms: Patellofemoral Pain Syndrome
Study type: Observational

Summary: 
      Restoration of patellar thickness is pivotal during a total knee arthroplasty (TKA). Several
      studies showed there are differences in the knee measurements between Asian and Western
      population. This study aims to evaluate the patellar dimension and Bristol Index of patellar
      width to thickness (BIPWiT) using magnetic resonance imaging (MRI) in Asian population.
    


Intervention name(s): MRI
Intervention type(s): Diagnostic Test
Intervention description(s): MRI genu non contrast
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        all patients came to clinic
Large Sample PD Patients and Healthy Controls
Condition: Neuro-Degenerative Disease
MeSH terms: Neurodegenerative Diseases
Study type: Observational

Summary: 
      Resting-state functional magnetic resonance imaging (RS-fMRI) has frequently been used to
      investigate local spontaneous brain activity in Parkinson's disease (PD) in a whole-brain,
      voxel-wise manner. To quantitatively integrate these studies, we conducted a coordinate-based
      meta-analysis on 15 studies that used amplitude of low frequency fluctuation (ALFF) and 11
      studies that used regional homogeneity (ReHo). All these ALFF and ReHo studies have compared
      PD patients with healthy controls. We also performed a validation RS-fMRI study of ALFF and
      ReHo in a frequency-dependent manner for a novel dataset consisting of PD and healthy
      controls.
    

Detailed description: 
      Seed-based d Mapping (formerly Signed Differential Mapping, SDM) software (version 5.141 for
      Windows) (www.sdmproject.com) was used for meta-analysis.

      For the validation, fMRI data were acquired on a 3 Tesla Magnetic Resonance scanner (Trio
      system; Siemens Magnetom scanner, Erlangen, Germany) with gradient-echo echo-plannar imaging
      sequences. Whole brain fMRI scanning was carried out. All participants were instructed to
      keep their eyes closed, relax, remain motionless, not think of anything in particular, and
      not fall asleep. Foam pads were used to minimize head motion.
    

Intervention name(s): MRI scan
Intervention type(s): Device
Intervention description(s): All participants underwent the MRI scan
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        PD patients were enrolled from the inpatients and the outptients. Healthy controlls were
        enrolled using advertisement (media and internet)
      
Biospecimen description: 
      no biospecimen was collected