Comparison of the Effect of Exercises on Vasomotor Symptoms in Middle Aged Women
Condition: Hot Flashes; Menopause
MeSH terms: Hot Flashes
Study type: Interventional

Summary: 
      Vasomotor symptoms (VMS) develop in the premenopausal period and symptoms may persist for
      years after menopause.Vasomotor symptoms such as hot flashes, night sweats, mood swings and
      sleep disturbances affect women's quality of life. There is a need for alternative treatments
      to reduce vasomotor symptoms due to the inadequacy of current treatments and the need for an
      effective treatment. Exercise is seen as a low-risk treatment to reduce vasomotor symptoms.
      Resistance trainig combined with aerobic training may be effective in reducing vasomotor
      symptoms and improving quality of life. The effects of the combination of resistance trainig
      2 days a week and aerobic trainig 3 days a week on vasomotor symptoms, quality of life, sleep
      disturbance and depression will be investigated and compared with the control group.
    

Detailed description: 
      The climacterium, which is seen in the transition of women from the fertile period to the
      life stage where they lose their fertility, is seen as a natural process of aging. The World
      Health Organization (WHO) defines menopause as "the permanent cessation of menstruation as a
      result of loss of ovarian activity". The diagnosis of menopause in women is made
      retrospectively, usually one year after the cessation of menstrual bleeding between the ages
      of 45-55. The climacteric period, which consists of four phases: premenopause, menopause,
      perimenopause and postmenopause, covers a period of time starting around the age of 40-45 and
      extending to the age of 65. The premenopausal period covers the period from the onset of
      menstrual irregularities and the first symptoms to menopause. The first symptoms in the
      premenopausal period can be seen 4 years before the cessation of menstrual bleeding.
      Perimenopause (transition to menopause) covers premenopause, menopause and the one-year
      period after menopause. The postmenopausal stage, on the other hand, takes place in a long
      period of time from one year after menopause in women to old age. During the climacteric
      period, women may experience various symptoms. Vasomotor symptoms (VMS), including both
      daytime hot flashes and night sweats during sleep, can be experienced by middle-aged women
      with regular menstrual cycles, with a prevalence peaking at approximately 79% in late
      perimenopause. Vasomotor symptoms affects approximately 60% to 80% of women report that they
      feel discomfort due to vasomotor symptoms and negatively affect their quality of life. In
      women, these symptoms last up to 1-2 years after menopause. However, some women may
      experience symptoms for 10 years or longer. Vasomotor episodes are usually felt as
      spontaneous warmth on the chest, neck, and face of women, and this condition has often been
      found to be associated with sweating, anxiety, and palpitations. These symptoms can be seen
      as hot flashes, night sweats and facial flushing. Vasomotor symptoms interrupt women's work
      and daily activities and may cause sleep problems that require medical treatment. Although
      the cause of vasomotor symptoms is not known exactly, it is thought to develop due to
      hormonal changes.

      Exercise is seen as a low-risk treatment to reduce vasomotor symptoms, but the evidence in
      the literature is inconclusive. Some observational studies have reported less VMS in
      physically active postmenopausal women than in sedentary women. Results from intervention
      studies are of low quality. The World Health Organization recommends resistance exercise
      twice a week for all adults. The American College of Sports Medicine (ACSM) recommends at
      least two days a week of resistance exercise, as well as aerobic activities three days a
      week. Exercise training is especially important in postmenopausal women, where decreases in
      muscle strength, bone mineral density and basal metabolic rate are accelerated. Previous
      studies, although limited, have focused on the effect of resistance training on vasomotor
      symptoms. In our current study, the effects of aerobic activity combined with resistance
      exercises on vasomotor symptoms, quality of life, sleep disturbance and depression will be
      investigated and compared with the control group.
    

Intervention name(s): Resistance and Aerobic Training
Intervention type(s): Other
Intervention description(s): For aerobic exercise, participants will do brisk walking 30 minutes in the first two weeks, 3-6. weeks will be 35 minutes, 7th and 8th weeks will be 40 minutes.The first and last 10 minutes of each walk will be said to be done at a slow pace, for the warm-up and cool-down periods. Participants will be called regularly to monitor their participation in the aerobic exercise program, and their compliance with the exercise will be checked, and they will be motivated to continue the exercises by providing the necessary information. Resistance exercises sessions will include five minutes of warm-up, forty minutes of resistance training and five minutes of cool-down. The training load will be provided by progressively increasing the repetitions. The Borg Scale will be used to adjust the exercise intensity. Rest time between sets will be 60 seconds.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Exercise; Hot flashes; Menopause; Resistance training; Aerobic exercise; Vasomotor symptoms; Quality of life; Sleep quality