bioihbjkbjnl/mcl2 huggingface dataset:
Multiple Disseminated Hydatidosis With Rare Locations
Condition: Echinococcus Infections
MeSH terms: Echinococcosis
Study type: Observational

Summary: 
      Hydatid disease is an anthropozoonosis due to the development of the larval form of
      Echinococcus granulosus in the human body, which constitutes a 'dead-end' host. It's a common
      parasitosis in North African countries and constitutes a public health problem in Morocco.
      The liver and lung are the most affected while the mediastinum, pancreas and pelvis are
      rarely affected. We report the case of a 40-year-old patient operated 15 years ago for
      cerebral and cervical hydatid cysts and who was hospitalized for generalized mucocutaneous
      jaundice. On exploration, we discover the presence of disseminated abdominal hydatidosis with
      association of 3 rare locations: mediastinal, pancreatic and pelvic. Indirect diagnostic
      tests were positive: indirect hemagglutination (IHA) and Elisa. The Western blot test also
      showed the presence of specific bands, thus making it possible to retain the diagnosis of
      hydatidosis.

      The hydatid cyst with mediastinal, pancreatic and pelvic location is rare and their
      association is very exceptional. It is essential to evoke the hydatid origin of any cystic
      lesion in a patient staying in an endemic area.
    


Intervention name(s): duct diversion
Intervention type(s): Procedure
Intervention description(s): the patient benefited from a diversion of the bile ducts complicated by ruptured cysts with anaphylactic shock
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        This is a descriptive study of a single patient with the particularity of having
        exceptional locations of hydatidosis.
      
Keywords: echinococcus; serology; multiple locations
Non-invasive Device for the Screening and Diagnosis of Sleep Apnea Syndrome
Condition: Obstructive Sleep Apnea
MeSH terms: Apnea; Sleep Apnea Syndromes; Sleep Apnea, Obstructive
Study type: Interventional

Summary: 
      This prospective study aims to establish and evaluate a predictive model to diagnose OSA with
      maxillofacial characteristics 3D acquisition.
    

Detailed description: 
      Polysomnography is the gold-standard for obstructive sleep apnea (OSA) diagnosis. However,
      OSA is still undiagnosed. Maxillofacial profile can influence OSA severity. Morphological
      characteristics can be identified but are not enough measurable and analysable by physicians.
      3D acquisition of maxillofacial characteristics with a user-friendly tool, quick and
      low-priced could be used to obtain a predictive model as an OSA risk indicator. Thus, the aim
      of this study is to establish and evaluate a predictive model to diagnose OSA with
      maxillofacial characteristics 3D acquisition.
    

Intervention name(s): 3D acquisition of maxillofacial characteristics
Intervention type(s): Diagnostic Test
Intervention description(s): A 3D acquisition of maxillofacial characteristics will be performed for each patient in order to validate a predictive model comparable to data obtained by polysomnography
Intervention model: Single Group Assignment
Intervention model description: Prospective
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Sleep apnea diagnosis; 3D acquisition
Effectiveness in Dental Plaque Reduction of Mouthwashes Containing Fatty Acids Compounds (F.A.G.) or Stannous Fluoride
Condition: Gingivitis; Gingival Diseases
MeSH terms: Gingivitis; Dental Plaque; Gingival Diseases
Study type: Interventional

Summary: 
      Comparative study on the efficacy of two mouthwashes Containing Fatty Acids Compounds
      (F.A.G.) or Stannous Fluoride in the reduction of plaque score in individuals with
      spontaneous gengivitis
    


Intervention name(s): Fatty Acids Compounds (F.A.G.) Mouthwash; Stannous Fluoride (SF) Mouthwash
Intervention type(s): Drug; Drug
Intervention description(s): Fatty Acids Compounds (F.A.G.) Mouthwash; Stannous Fluoride (SF) Mouthwash
Intervention MeSH terms: Fluorides; Tin Fluorides
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment
Flexible Electronics for Early Assessment
Condition: Very Low Birth Weight Infant
MeSH terms: Birth Weight
Study type: Interventional

Summary: 
      The morbidities associated with very low birth weight (VLBW) infants constitute a major
      health problem and a significant emotional and financial burden for families and our nation.
      The key to reducing this burden is early diagnosis. This research will be the first step
      towards intervention for cerebral growth and long-term neurodevelopmental morbidities of VLBW
      infants.

      The proposed research is to design and fabricate a new technological innovation in wearable
      soft-sensors, called flexi-mitts, for measuring force modulation and joint angles of the hand
      (wrist and fingers) of toddlers. Building upon the investigators' ongoing work, they plan to
      engineer stretchable electronics for safe, toddler-scaled flexi-mitts to measure planning and
      force modulation.

      The investigators' new flexi-mitt technology has the potential to provide a new diagnostic
      technology and the development of clinical assessment norms. With additional trials of the
      technology in large numbers of young children, it may be possible for clinicians and day care
      providers to eventually make measurements of planning and force modulation in play settings.
    


Intervention name(s): FlexiMitt
Intervention type(s): Device
Intervention description(s): The proposed research designs and fabricates a new technological innovation in wearable soft-sensors, called flexi-mitts, for measuring force modulation and joint angles of the hand (wrist and fingers) of toddlers.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Device Feasibility
Detection of Chlamydia (CT) and Gonorrhea (NG)
Condition: Chlamydia; Gonorrhea
MeSH terms: Chlamydia Infections; Gonorrhea
Study type: Observational

Summary: 
      To evaluate the illumigene Chlamydia and illumigene Gonorrhea assays, using the illumipro-10,
      with male urine, female urine, physician-collected (medical professional) endocervical swabs
      and self-collected vaginal swabs taken from symptomatic and asymptomatic patient populations.
    


Intervention name(s): illumigene CT and NG assays, illumipro-10
Intervention type(s): Device
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Symptomatic and asymptomatic subjects at least 14 years of age
      
Biospecimen description: 
      Leftover urine samples
Kisspeptin Levels in Early Pregnancy
Condition: Early Pregnancy; Ectopic Pregnancy
MeSH terms: Pregnancy, Ectopic; Cardiac Complexes, Premature
Study type: Observational [Patient Registry]

Summary: 
      Kisspeptins are a family of neuropeptides that are critical for the puberty initiation and
      female fertility. The investigators aimed to investigate in this study kisspeptin levels in
      early pregnancy, ectopic pregnancy, and early pregnancy loss.
    

Detailed description: 
      Clinicians can easily do a differential diagnosis of early pregnancy, miscarriage, and
      ectopic pregnancy when the human chorionic gonadotropin (hCG) values higher than 2000 mIU/mL
      with transvaginal ultrasound. However, in cases where the hCG value is below the critical
      threshold of 1500 to 2000 mIU/mL (often called the discrimination level) and ultrasound is
      not likely to be diagnostic, the pregnancy is of unknown location. Plasma or serum kisspeptin
      is mainly derived from the placenta during pregnancy and plasma kisspeptin levels
      significantly increase across pregnancy. Plasma kisspeptin levels could be used as a
      potential biomarker for the discrimination of miscarriage and ectopic pregnancy.

      All statistics will be carried out with the use of SPSS (ver. 21, IBM). A P value of <.05 is
      considered to be statistically significant. Pearson chi-square test will be used to evaluate
      between-group differences by pregnancy outcome for categoric data. Kisspeptin differences
      will be calculated between groups with one way ANOVA.
    

Intervention name(s): blood test
Intervention type(s): Diagnostic Test
Intervention description(s): blood test (serum samples) for biochemical examination
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Women were considered for the study if they presented between 5-6 weeks of gestation by
        last menstrual period. Patients were included if they had either confirmed intrauterine
        pregnancy (IUP) by ultrasound (n=22) or confirmed miscarriage (SAB) by ultrasound (n=20) or
        ectopic pregnancy.
      
Biospecimen description: 
      Kisspeptin is a family of peptide hormones encoded by the KISS1 gene. Kisspeptin acts
      centrally via the kisspeptin receptor to stimulate the release of gonadotropin-releasing
      hormone (GnRH) from the hypothalamus and has a critical role in the initiation of puberty.
      Kisspeptin was first discovered as an inhibitor of tumor metastasis and, as a result, was
      previously known as metastatin. Kisspeptin is also found in high levels in first-trimester
      syncytiotrophoblast cells.
    
Keywords: kisspeptin; ectopic pregnancy
Renal Effects of Hormones/Biomarkers in Transgender PrEP Recipients
Condition: Transgender; Renal Function; Hormone Replacement Therapy
Study type: Interventional
Phase: Phase 4

Summary: 
      Will use a subset of the main study cohort of transgender or non-binary individuals to
      evaluate the relationships between self-reported exogenous hormone use, endogenous hormone
      values, renal biomarkers, drug levels and directly measured renal function.
    

Detailed description: 
      This cross-sectional sub-study will use a subset of the main study cohort of transgender (TG)
      or non-binary (NB) individuals to evaluate the relationships between self-reported exogenous
      hormone use, endogenous hormone values (serum estradiol, estrone, free/total testosterone),
      renal biomarkers, drug levels (measured by tenofovir diphosphate, TFV-DP, and emtricitabine
      triphosphate, FTC-TP, on dried blood spot cards and urine) and directly measured renal
      function (iohexol clearance).
    

Intervention name(s): IHX-CL measurements; Iohexol
Intervention type(s): Diagnostic Test; Drug
Intervention description(s): The distribution of measured IHX-CL values and other continuous variables will be assessed to ensure a parametric distribution.; Iohexol clearance measurement
Other intervention name(s): OMNIPAQUE; Iohexol; OMNIPAQUE
Intervention model: Single Group Assignment
Intervention model description: iohexol
Masking: None (Open Label)
Primary purpose: Diagnostic
PET (Positron Emission Tomography)/Public Speaking Study With A Combination Of 2 Medications In Social Anxiety Patients
Condition: Depressive Disorder and Anxiety Disorders
MeSH terms: Anxiety Disorders; Depressive Disorder
Study type: Interventional
Phase: Phase 2

Summary: 
      This six-arm study is being conducted to measure the effect of a combination of paroxetine
      and vestipitant on the arousal induced by public speaking in Seasonal Effective Disorder
      (SAD) patients, using functional brain imaging readouts (i.e., WAT(Wave Analysis Technology)
      PET(Positron Emission Tomography)), after one or eight weeks of treatment. The effect of
      paroxetine alone after one or eight weeks of treatment will also be measured.
    

Detailed description: 
      A double-blind, double dummy, placebo-controlled, randomised, parallel group positron
      emission tomography study to investigate the effects of a 8 week administration of
      vestipitant and paroxetine in combination or paroxetine alone on regional cerebral blood flow
      during a public speaking test in subjects affected by social anxiety disorder.
    

Intervention name(s): vestipitant; paroxetine
Intervention type(s): Drug; Drug
Other intervention name(s): vestipitant
Intervention MeSH terms: Paroxetine; Vestipitant
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Social Anxiety Disorder; brain imaging; Positron Emission Tomography; antidepressant
High Flavonols Cocoa Intake for the Improvement of Body Fat Composition in Athletes
Condition: Healthy Subjects
Study type: Interventional

Summary: 
      The decrease in body fat percentage improves exercise performance, reducing race time. The
      intake of cocoa improves the body fat composition in obese and diabetic people by improving
      their cardiovascular disease risk factors. Although epidemiological studies indicate that
      healthy subjects who consume cocoa have lower body fat composition, there is no study
      indicating whether cocoa improves fat composition in athletes. The aim of the study was to
      determine if the intake of cocoa rich in flavonoids improves the fat composition of athletes,
      modifying the systemic levels of adipokines (folistatin, myostatin and leptin), resulting in
      an improvement of physical performance.
    

Detailed description: 
      The objective of this project was to investigate the effects of chronic daily consumption of
      high in flavanols cocoa in body composition and performance of endurance athletes:

      A randomized, blinded, parallel placebo controlled intervention study was carried out in
      endurance athletes . The number of male athletes enrolled in the study was 40, with ages
      between 18 and 50 years and an aerobic power consumption of oxygen greater than or equal to
      55 mL / kg / min). The intervention was carried out for 10 weeks. Cocoa or placebo
      (maltodextrin) were supplied in sachets of a single daily dose. Cocoa provided 425 mg of
      flavanols/ day.

      Athlete's body composition was evaluated by dual-energy X-ray absorptiometry (DEXA). Exercise
      performance was evaluated with a treadmill test protocol determining the maximum aerobic
      capacity and also by determining the time necessary to run a kilometer at maximum speed.

      Adipokines (follistatin, myostatin and leptin) in plasma and serum samples were determined by
      ELISA.

      Diet was determined by three 24h-recall questionnaries and a Food Frecuency questionnaire.
    

Intervention name(s): Cocoa group; Placebo group
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Athletes performed a training program and consumed 5 g of cocoa (425 mg of flavonoids) mixed with semi-skimmed fat milk, daily for 10 weeks.; The athletes performed the same training program of the cocoa group and they took for 10 weeks 5 g of maltodextrin mixed with semi-skimmed fat milk.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Placebo controlled study
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Nutritional Supplement; High in flavanoids cocoa; Body Fat composition; Physical Exercise performance
Effect of Tesofensine on Energy Balance in Humans.
Condition: Obesity
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      Purpose:

      To evaluate the effect of tesofensine on energy balance
    


Intervention name(s): Tesofensine
Intervention type(s): Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Combination of Cryosurgery and NK Immunotherapy for Advanced Esophageal Cancer
Condition: Metastatic Esophageal Cancer
MeSH terms: Esophageal Neoplasms
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The aim of this study is the safety and efficacy of cryosurgery plus NK immunotherapy to
      advanced esophageal cancer.
    

Detailed description: 
      By enrolling patients with pancreatic cancer adapted to enrolled criteria, this study will
      document for the first time the safety and the short and long term efficacy of the combined
      therapy using cryosurgery and nature killer (NK) cells for advanced esophageal cancer.

      The safety will be evaluated by statistics of adverse reactions.The efficacy will be
      evaluated according to local relief degree, progress free survival (PFS) and overall survival
      (OS).
    

Intervention name(s): Cryosurgery; NK immunotherapy
Intervention type(s): Device; Biological
Intervention description(s): Argon-helium cryosurgical system; Nutral killer cell immunotherapy for more than 6 times
Intervention MeSH terms: Immunomodulating Agents
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Esophageal Cancer; NK immunotherapy; Safety; Efficacy
Safety and Efficacy Study of a New Intermittent Pneumatic Compression Device to Treat Patients With Peripheral Arterial Disease (PAD) Stage II
Condition: Peripheral Arterial Disease
MeSH terms: Peripheral Arterial Disease; Peripheral Vascular Diseases
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the safety and efficacy of new intermittent
      pneumatic compression device on initial claudication distance in patients with Peripheral
      Arterial Disease stage II
    

Detailed description: 
      Patients with Peripheral Arterial Disease (PAD) suffer from symptoms such as intermittent
      claudication, limb and foot pain and tissue lesions, which are difficult to treat. In recent
      years, there have been reports demonstrating reduction of these symptoms by use of
      compressible sleeve devices.

      This clinical study aims at demonstrating the safety and effectiveness of this device in
      treating PAD symptoms.
    

Intervention name(s): AngioPress Intermittent pneumatic compression (IPC) Device; Medications and Standard walking exercises
Intervention type(s): Device; Other
Intervention description(s): Treatment with Intermittent pneumatic compression (IPC) for PAD; Aspirin/Clopidegrol and Standard walking exercises
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Care Provider)
Primary purpose: Treatment
Keywords: Peripheral Arterial Disease; intermittent pneumatic compression treatment; Initial claudication
A Bioequivalence (BE) Study Comparing The Commericializable And Clinical Formulations Of PF-00299804
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      The study will determine if bioequivalence can be claimed between the proposed
      commericializable formulation and the current clinical formulation. Specifically, if the 90%
      confidence intervals of the ratio for Area under the curve (AUC) and maximum concentration
      (CMax) are within the 80%-125% guidance limits.
    

Detailed description: 
      A bioequivalence (BE) study between two formulations of PF-00299804.
    

Intervention name(s): Treatment A-B; Treatment B-A
Intervention type(s): Drug; Drug
Intervention description(s): Subjects to receive 3 X 15 mg tablets of the clinical formulation in first period then 1 x 45 mg tablet of the commericializable formulation in 2nd period.; Subjects to receive 1 x 45 mg tablet of the commericializable formulation in first period then 3X 15 mg tablets of the clinical formulation in 2nd period.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Keywords: Bioequivalence (BE) Study; Healthy Volunteers
Sustained Acoustic Medicine for Knee Osteoarthritis Pain
Condition: Knee Osteoarthritis
MeSH terms: Osteoarthritis; Osteoarthritis, Knee
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to compare Sustained Acoustic Medicine treatment to topical pain
      relief gel for the symptomatic management of knee osteoarthritis. The study will measure pain
      and function scores for patients undergoing treatment.
    


Intervention name(s): Sustained Acoustic Device with 2.5% Diclofenac Patch; Placebo Sustained Acoustic Device with 0% Diclofenac Patch; 1% Diclofenac Topical Gel
Intervention type(s): Device; Device; Drug
Intervention description(s): Patients apply the SAM Ultrasonic Diathermy Device daily for 1-4 hours of continuous therapeutic ultrasound at 3 megahertz(MHz) frequency and 0.132 Watts/cm@ with 2.5% Diclofenac patches.; Patients apply the placebo SAM Ultrasonic Diathermy Device daily for 1-4 hours with 0% Diclofenac patches.; Topical pain-relief gel
Other intervention name(s): ZetrOZ Ultrasound Device; Wearable Ultrasound Device; Long Duration Ultrasound; LITUS DeviceWearable; Long Duration Low-Intensity Device; ZetrOZ Ultrasound Device; Ultrasound Device; Long Duration Ultrasound; LITUS DeviceWearable; Long Duration Low-Intensity Device; Voltaren
Intervention MeSH terms: Diclofenac
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Continuous ultrasound; Sustained Acoustic Medicine; Musculoskeletal Injuries; Low Intensity Contiguous Ultrasound; Pain; Joint Injury; Osteoarthritis