Prevention of Osteoporosis: Effects of Mini-trampoline Training on the Bone Remodeling
Condition: Perimenopausal Bone Loss; Postmenopausal Osteopenia
MeSH terms: Bone Diseases, Metabolic; Osteoporosis, Postmenopausal
Study type: Interventional

Summary: 
      The aim of the project is to study the effects on bone remodeling induced by training carried
      out with the trampoline in order to evaluate the reduction of the resorption itself and
      therefore the onset of osteoporosis in women.
    

Detailed description: 
      Bone mineral density is modified by various factors and in particular by diet, nutritional
      status and exercise recommended to preserve or increase bone mass in adults. The degree of
      bone formation and resorption can be assessed by measuring bone resorption markers in the
      blood or urine. To date, there is no information about the effect of training with an elastic
      trampoline on the reduction of bone resorption. The aim of the project is to study the
      effects on bone remodeling induced by training carried out with the trampoline, in order to
      evaluate the reduction of the resorption itself and therefore the onset of osteoporosis in
      women. To examine whether exercise affects bone remodeling, the C-terminal telopeptide bone
      resorption markers (CTX) and osteocalcin formation marker will be measured. For the
      evaluation of bone metabolism osteocalcin parathyroid hormone, Calcitonin, Vitamin D,
      Calcium, albumin, Phosphate, Potassium markers will be evaluated. The markers can be detected
      in serum. Women with no previous experience with the trampoline activity will participate in
      the project randomly assigned to the experimental training group (Jumpers) or to the control
      group, who will not do any training during the observation period (not Jumpers). The control
      group will be inserted in order to compare the data and further verify the efficiency of the
      treatment. Blood samples for bone resorption assay will be collected on the first day of
      training with the trampoline and 20 weeks. Each training session will be monitored by
      detecting heart rate (heart rate monitor) and subjective perception of fatigue (Borg scale).
      Each subject will be subjected to two venous blood samples taken at the beginning of the
      observation and at the end. The samples thus obtained will be transported in certified
      containers for the safe transport of biological samples, and, subsequently, processed by the
      experimenters at the laboratories of the Molecular Biology section of the University of
      Palermo. Serum and plasma will be obtained from each blood sample. All information thus
      obtained will be recorded in a database in which each person will be identified with a
      numerical code, in order to comply with current privacy regulations. Body weight, Barefoot
      standing height, Body mass index, Body composition will be measured in the different groups
      of study. Blood samples will be collected from the different groups of study. Samples will be
      analyzed and compared for Osteocalcin, parathyroid hormone, CTX, Calcitonin, Vitamin D
      Calcium, albumin, Phosphate, Potassium.
    

Intervention name(s): physical activity
Intervention type(s): Other
Intervention description(s): training with trampoline. Each session lasted sixty minutes. Organization: a 5 minutes warm-up with breathing and mobility exercises from upper to lower body, central phase with jumping exercises involving the total body and 5 minutes of cool-down phase with total body active stretching exercise.
Other intervention name(s): SuperJump® Training
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The control group not performed physical activity during the time of the study. In the exercise group SuperJump® training was performed for three times a week, each session lasting 60 minutes for a total of 20-weeks.
Masking: None (Open Label)
Primary purpose: Prevention