bioihbjkbjnl/mcl2 huggingface dataset:
The Value of Traction in Treatment of Lumbar Radiculopathy
Condition: Sciatica; Radiculopathy; Spinal Diseases; Musculoskeletal Diseases; Neuromuscular Diseases; Intervertebral Disk Displacement
MeSH terms: Musculoskeletal Diseases; Spinal Diseases; Intervertebral Disc Displacement; Radiculopathy; Neuromuscular Diseases; Sciatica
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to determine the effectiveness of adding mechanical traction to
      standard physical therapy treatments for patients with low back pain.
    

Detailed description: 
      Despite the opinions of clinical experts that patients who might benefit from traction may
      represent distinct sub-groups of patients, most studies have not attempted to narrow their
      inclusion criteria beyond loose definitions of 'acute' or 'chronic' symptoms. While these
      studies seem to indicate that traction interventions will be of little benefit when
      administered to large groups of patients without a prior attempt to select which patients are
      most likely to benefit, they are not sufficient to preclude the possibility that a subgroup
      of patients may benefit substantially from the intervention. Recent preliminary studies
      suggest a there exists a subgroup of patients with LBP that is likely to benefit from
      traction.

      The two primary aims of this study are:

        1. Determine the validity of the previously-identified prediction criteria to identify
           patients highly likely to benefit from the addition of traction to a standard physical
           therapy intervention.

        2. Compare the overall effectiveness of addition of a traction component to a standard
           physical therapy intervention.
    

Intervention name(s): Physical therapy rehabilitation; Physical therapy rehabilitation
Intervention type(s): Other; Other
Intervention description(s): Extension oriented exercises. Subjects will be instructed in a progression of extension oriented exercises for the lumbar spine; Mechanical lumbar traction will be applied with subjects in prone utilizing 40-60% of subject's body weight to create a distraction force in the lumbar spine. Following traction, subjects will be instructed in a progression of extension oriented exercises and manual therapy to increase extension as described for the comparator group.
Other intervention name(s): McKenzie exercises; Directional preference; Specific exercise; Saunders 3D Active Trac
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Treatment
Keywords: Sciatica; Radiculopathy; Physical therapy modalities; Rehabilitation
Pilot Study of Cyclophosphamide in Patients With Life-Threatening Systemic Lupus Erythematosus or Antiphospholipid Antibody Syndrome
Condition: Systemic Lupus Erythematosus; Antiphospholipid Antibody Syndrome
MeSH terms: Lupus Erythematosus, Systemic; Antiphospholipid Syndrome; Syndrome
Study type: Interventional

Summary: 
      OBJECTIVES:

      I. Determine the induction of durable remission in patients with life-threatening systemic
      lupus erythematosus or antiphospholipid antibody syndrome treated with cyclophosphamide.

      II. Determine the toxicity of this drug in these patients.
    

Detailed description: 
      PROTOCOL OUTLINE:

      Patients receive cyclophosphamide IV on days 1-4 and filgrastim (G-CSF) beginning on day 10
      and continuing until blood counts recover.

      Patients are followed monthly for 6 months, and then every 3 months thereafter.
    

Intervention name(s): Cyclophosphamide; filgrastim
Intervention type(s): Drug; Drug
Intervention MeSH terms: Cyclophosphamide
Allocation: Non-Randomized
Primary purpose: Treatment
Keywords: antiphospholipid antibody syndrome; arthritis & connective tissue diseases; immunologic disorders and infectious disorders; rare disease; systemic lupus erythematosus
Restylane® Skinboosters™ Vital in the décolletage Region
Condition: Decolletage Rejuvenation
Study type: Interventional
Phase: Phase 4

Summary: 
      Restylane® Skinboosters™ Vital (SBV) is a smooth formulation without particles, which helps
      it distribute evenly and smoothly under the skin to aid in rejuvenation. This feature makes
      RSV particularly well suited for more superficial injections, such as at the level of the
      dermis.

      SBV smooths fine lines and wrinkles and is intended to improve skin smoothness and
      appearance, as well as the elasticity and hydration of the skin in the face and dorsal hands.
      However, many clinicians have used SBV in other regions of the body. Given these attributes,
      SBV are particularly well suited for photo aged skin. A region that is susceptible to
      photo-ageing and may therefore benefit from the use of SBV is the décolletage. Photodamaged
      skin of the chest is characterized by atrophy, skin laxity, fine lines and wrinkles,
      dehydration and tactile roughness. Therefore, SBV may help to improve these signs of aging in
      the décolletage region.

      Study Aim: To investigate the effectiveness and tolerability of SBV for rejuvenation of the
      décolletage region.
    


Intervention name(s): Restylane® Skinboosters™ Vital (SBV)
Intervention type(s): Device
Intervention description(s): Hyaluronic acid
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
How Does Magnesium Status Influence Calcium Homeostasis?
Condition: Magnesium Deficiency; Calcium Metabolism Disorders
MeSH terms: Metabolic Diseases; Magnesium Deficiency; Calcium Metabolism Disorders
Study type: Interventional
Phase: Phase 4

Summary: 
      The investigators aim to recruit 60 women who have agreed to participate in an existing
      randomized, double-blind, placebo-controlled trial (Treatment of Vitamin D Insufficiency, HSC
      2009-0055). In this trial, the investigators propose to evaluate the associations between
      magnesium intake, magnesium stores, fractional magnesium absorption and calcium homeostasis.
      The investigators will stratify 60 subjects in the sub-study, ensuring that approximately 20
      subjects are randomized into each treatment arm (placebo, low-dose and high-dose vitamin D).
      The investigators already assess calcium homeostasis throughout the study by measuring bone
      mineral density, fractional calcium absorption, serum and urine calcium levels, among other
      tests. In the sub-study of 60 women, the investigators will evaluate whether habitually
      higher magnesium intake increases or decreases fractional calcium absorption. The
      investigators will evaluate the interplay between magnesium stores, vitamin D levels and
      serum parathyroid hormone levels. The investigators will directly assess magnesium stores
      using serum magnesium and 24-hour urine magnesium levels, and will measure magnesium
      absorption using the dual stable isotope approach.
    

Detailed description: 
      Use of serum magnesium isotopes to measure fractional magnesium absorption Four day food
      diaries to assess magnesium intake Standard urine and serum chemistries for remaining labs as
      noted above
    

Intervention name(s): vitamin D3
Intervention type(s): Dietary Supplement
Intervention description(s): pharmaceutical grade D3
Other intervention name(s): Cholecalciferol
Intervention MeSH terms: Vitamin D; Cholecalciferol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: vitamin D; cholecalciferol; bone mineral density; Magnesium deficiency; Calcium metabolism disorders
Clinical and Hemodynamic Evaluation After Venous Recanalization of Post-thrombotic Iliofemoral Syndromes
Condition: Venous Recanalisation
MeSH terms: Syndrome
Study type: Observational

Summary: 
      Post-thrombotic syndrome (PTS) is the most common chronic complication of deep vein
      thrombosis (DVT). The endovascular recanalization and stenting technique has become the gold
      standard treatment for medically resistant and disabling PTS.

      Stent thrombosis is a significant complication of this procedure; the risk factors for
      thrombosis are poorly understood.

      Monitoring the patency of the stent is a key component in maintaining clinical success.

      Doppler ultrasound is the first-line diagnostic tool for monitoring patients with venous
      stents, and has the potential to allow accurate assessment of venous stent obstruction.

      Absence of validated morphological and hemodynamic echodoppler criteria for the follow-up of
      these stents.

      • Main objective: Clinical and hemodynamic results of venous recanalisations by stenting in
      the chronic phase

      • Secondary objective (s):

        -  External validation of hemodynamic criteria proposed in the literature to detect venous
           stent obstruction

        -  Risk factors for venous stent restenosis
    


Intervention name(s): Basic demographic information
Intervention type(s): Other
Intervention description(s): Basic demographic information: age, sex, weight, height, BMI. Comorbidities: history of major bleeding, cardiovascular comorbidities, diabetes mellitus, renal failure, smoking, hormone therapy Anticoagulant and antiplatelet therapy (molecule, duration and indication, before and after intervention) Procedure data: number and type of stents implanted, diameters and lengths, name of stented venous segments Postoperative complications: bleeding complications, pelvic pain, early thrombosis, early pulmonary embolism
Clinical examination carried out 1 month after the operation and more than 6 months after the operation
Data from the control ultrasound performed 1 month after the operation and more than 6 months after the operation
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Population with a disabling post-thrombotic syndrome (venous claudication) after at least 6
        months of proximal deep vein thrombosis.
      
Keywords: Post-thrombotic syndrome; Deep vein thrombosisA; Endovascular recanalization and stenting; Morphological and hemodynamic echodoppler criteria; Venous stent restenosis
Serratus Plane Block vs Erector Spinae Plane Block on Postoperative Analgesia in Patients Undergoing Unilateral Breast Surgery
Condition: Breast Cancer; Postoperative Pain
MeSH terms: Pain, Postoperative
Study type: Interventional
Phase: Phase 4

Summary: 
      Interfacial plan blocks are becoming more widely used for postoperative analgesia because of
      their easier applicability and less risk of complications. In this study, we aimed to compare
      the effects of serratus plane block (SPB) and erector spinae plane block (ESPB) on
      postoperative analgesia in patients undergoing unilateral breast surgery
    


Intervention name(s): Bupivacaine Injection
Intervention type(s): Drug
Intervention description(s): Block with bupivacaine
Intervention MeSH terms: Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: serratus plane block, erector spinae plane block, postoperative analgesia
Thromboprophylaxis After Surgery for Gynecologic Malignancy in China
Condition: Gynecologic Neoplasms; Venous Thromboembolism; Low Molecular Weight Heparin; Argatroban
MeSH terms: Genital Neoplasms, Female; Thromboembolism; Venous Thromboembolism
Study type: Interventional
Phase: Phase 3

Summary: 
      Venous thromboembolism (VTE) is an important cause of post-operative morbidity and mortality
      in women undergoing surgery for gynecologic malignancies. Although the benefit of
      thromboprophylaxis in reduction of post-operative VTE events after surgery for gynecologic
      cancers has been well documented around the world, the evidence for Chinese women is rare.
      The investigators designed this prospective and randomized study to assess the benefit of
      pharmacologic prophylaxis for patients received surgical treatment for gynecologic
      malignancies in China.
    


Intervention name(s): s-LMWH; LMWH; Argatroban
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 2125KU, subcutaneous injection of 5-10 days; 4250KU, subcutaneous injection of 5-10 days; 20mg, injection for 5-10 days
Intervention MeSH terms: Heparin, Low-Molecular-Weight; Tinzaparin; Dalteparin; Argatroban
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Multicomponent Risk Factor Intervention for People With a Severe Mental Illness: a Feasibility Study
Condition: Psychotic Disorder; Obesity; Behavior, Addictive
MeSH terms: Mental Disorders; Psychotic Disorders; Behavior, Addictive
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is a feasibility study of a multi-component intervention to enhance healthy living
      among young people with psychotic disorders, specifically targeting smoking and weight.
    

Detailed description: 
      We propose a feasibility study of a multi-component intervention to enhance healthy living
      among young people (18 to 40 years) with psychotic disorders, specifically targeting smoking
      and weight. Smoking is very common amongst people with psychotic disorders (around 70% of
      males, and over 50% of females) and this adds to the overall cardiovascular risk for this
      group. Obesity is also a common problem for people with psychosis, with an estimated 40-60%
      being obese or overweight. Obesity in this population may contribute to adverse medical and
      psychological consequences. For many obese people, targeted pharmacotherapy in addition to
      diet and increased physical activity can assist in both weight reduction and the maintenance
      of gains. Similarly, smoking cessation is enhanced by use of adjunctive medications such as
      nicotine replacement; such strategies continue to produce abstinence rates for up to 10
      years.

      The proposed study will assess the feasibility of a multi-component behavioural intervention
      focussing on smoking cessation/diet/physical activity.

      The primary outcome measures from the feasibility study are smoking cessation and reduction
      in body mass index (BMI). Secondary outcomes will include tolerability and safety, as well as
      the impact the package has on other cardiovascular risk factors including serum lipids, blood
      sugar levels and depression in young people with psychosis. We will also establish whether
      smoking cessation and reduction in obesity is correlated with gains in terms of body image,
      quality and enjoyment of life and reduction in depression. Based on published data,
      behavioural interventions for smoking cessation and diet and physical activity lead smoking
      cessation in 20% of people at 12 months and to modest weight loss (around 5%).
    

Intervention name(s): nicotine transdermal patch/lozenge
Intervention type(s): Drug
Intervention MeSH terms: Nicotine
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Study of A3309 in Patients With Dyslipidemia
Condition: Dyslipidemia
MeSH terms: Dyslipidemias
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this trial is to determine the efficacy and safety of A3309 administered to
      patients with dyslipidemia (high cholesterol levels).
    


Intervention name(s): A3309; A3309; Placebo
Intervention type(s): Drug; Drug; Drug
Intervention description(s): A3309 in two different dosage levels; A3309 in two different dosage levels for the duration of the study; Placebo comparator once daily for the duration of the trial
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: dyslipidemia; cholesterol; LDL
Transepithelial Corneal Collagen Cross-linking (CXL) in Treatment of Keratoconus
Condition: Keratoconus
MeSH terms: Keratoconus
Study type: Interventional
Phase: Phase 2

Summary: 
      Transepithelial CXL (performed without epithelial removal) seem to have similar clinical
      effect on keratoconic eyes compared to the standard CXL (which includes epithelial removal).
      The current study attempts to prove that hypothesis.

      A prospective, controlled, randomized, contralateral trial, will involve one eye of the
      patient to be treated with transepithelial CXL, while the control eye will be treated with
      the standard CXL. Totally 20 patients (age >18 and <40 years) referred by an ophthalmologist
      to the eye department of the University Hospital North Norway for CXL treatment of bilateral
      progressive keratoconus, will be recruited.
    

Detailed description: 
      CXL appears to hinder the development of keratoconus by strengthening the cross-bindings in
      the corneal stroma with a resultant increase in corneal biomechanical strength of up to 300%.
      The method was introduced in the mid-nineties and has been approved for use in the EU
      countries since 2007. Standard treatment protocol, involving the removal of the corneal
      epithelium before the Riboflavin application, has been used. In order to avoid potential
      complications following removal of the epithelium (infection, delayed healing, scar
      formation, as well as discomfort and pain), a modified procedure where the epithelium is kept
      intact, so called transepithelial CXL, has been suggested. According to the preliminary
      results of the published retrospective studies, no significant difference in the clinical
      effect between the standard CXL with epithelial removal and the transepithelial CXL was
      found.
    

Intervention name(s): CXL without epithelial removal; CXL with epithelial removal
Intervention type(s): Procedure; Procedure
Intervention description(s): UV-radiation of a Riboflavin saturated cornea without prior epithelial removal; UV-radiation of a Riboflavin saturated cornea after surgical epithelial removal has been performed
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
TACE Combined With RFA/MV Treatment in Hepatocellular Carcinoma Beyond Milan Criterial
Condition: Hepatocellular Carcinoma
MeSH terms: Carcinoma; Carcinoma, Hepatocellular
Study type: Interventional
Phase: Phase 3

Summary: 
      This study was designed to evaluate the effectiveness of radiofrequency /microwave ablation
      in patients with hepatocellular carcinoma beyond Milan Criteria.
    

Detailed description: 
      The aim of this study is to included 120 patients with intermediate stage hepatocellular
      carcinoma beyond Milan criteria .These patients were randomizedly allocated to TACE treatment
      group or TACE+RFA/MV .The treatment effectiveness, local tumor control and survival outcome
      between the two groups were compared.
    

Intervention name(s): Transcatheter arterial chemoembolization; radiofrequency ablation/microwave ablation
Intervention type(s): Device; Device
Intervention description(s): Transcatheter arterial chemoembolization; radiofrequency ablation/microwave ablation
Other intervention name(s): TACE; RFA/MW
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: TACE vs.TACE+RFA
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Using Mean Ages on Clothing Size Labels in Revised Advanced Pediatric Life Support Formulas for Weight Estimation
Condition: Body Weight
MeSH terms: Body Weight
Study type: Observational

Summary: 
      Weight calculation based on age could be performed according to APLS (Advanced Pediatric Life
      Support) guideline recommendations in children requiring emergency treatment and intervention
      in the field or during resuscitation with no active weight and height measurements. The aim
      of the study is to investigate the suitability of weight calculation using mean ages on
      clothing size labels (ACL) to the actual weight in real emergencies with no known actual age
      of the patient (AA).
    

Detailed description: 
      Weight calculation based on age could be performed according to APLS guideline
      recommendations in children requiring emergency treatment and intervention in the field or
      during resuscitation with no active weight and height measurements. Age formulas require only
      knowledge of the actual age of the child and widely used all over the world with being
      catchy. However, situations in which one has to intervene a child without having any patient
      data, including information on children's ages, especially in the field or during
      resuscitation are not uncommon. The objective of this study is to investigate the
      availability of age information contained in clothing size labels of children in weight
      calculation according to APLS recommendations. Usability of labels can protect victims from
      overdose and underdose problems in cases where the actual age is unknown and the measurements
      cannot be done
    

Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Data of children, aged between 1 to 12 years, were consecutively collected. Patients were
        divided into two groups as under the age of 6 (age <6) and over 6 years of age (age≥6).
      
Keywords: weight estimation; emergency; child
Pulmonary Hypertension in Haemodialysis Patients :Frequency and Risk Factors
Condition: Pulmonary Hypertension
MeSH terms: Hypertension, Pulmonary; Hypertension
Study type: Observational

Summary: 
      High mortality rates due to cardiovascular disease in end-stage renal disease patients been
      described by epidemiological and clinical studies. It accounts for approximately 50 percent
      of deaths in dialysis patients. Although controversial, this may be due to the presence of
      excess vascular calcification particularly in the form of extensive coronary artery
      calcification which can be observed even in very young dialysis patients. It was suggested
      that abnormalities of the right ventricular function in patients with end-stage renal disease
      were largely due to pulmonary hypertension which usually develops secondary to pulmonary
      artery calcifications.
    

Detailed description: 
      Primary whose mechanisms are incompletely known, is another vascular disease entity recently
      described in chronic kidney disease particularly in patients undergoing haemodialysis. It
      corresponds to 5th subtype of World Symposium on Pulmonary Hypertension classification
      established in 2008 in Dana Point and updated in 2013 in Nice. Pulmonary hypertension is
      defined by Pulmonary arterial pressure mean ≥25 mm Hg at rest measured by right heart
      catheterization. Its pathophysiological mechanism is controversy maybe explained by vascular
      calcification, blood flow in arteriovenous fistula and fluid overload. Primary pulmonary
      hypertension is a major problem of haemodialysis patients because of its high prevalence,
      sometimes reaching 68% and by its significant morbidity and mortality.
    

Intervention name(s): plain chest x-ray
Intervention type(s): Radiation
Intervention description(s): the participants will be subjected to plain chest x-ray with other tools to help diagnose pulmonary hypertension in haemodialysis patients
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        80 subjects undergoing haemodialysis for more than one year will be subjected to some
        diagnostic tools to detect and know the frequency of pulmonary hypertension(PH) among those
        patients.
      
Keywords: cardiovascular complications