Comparison of Nebulized Ketamine to Intravenous Sub-Dissociative Dose Ketamine for Pain
Condition: Pain
Study type: Interventional
Phase: Phase 4

Summary: 
      Ketamine is a non-competitive N-methyl-D-aspartate (NMDA)/glutamate receptor complex
      antagonist that decreases pain by diminishing central sensitization, hyperalgesia, and
      "wind-up" phenomenon at the level of the spinal cord (dorsal ganglion) and central nervous
      system (1). Ketamine administration in sub-dissociative doses (SDK) of 0.1-0.3 mg/kg in
      pre-hospital settings and in the ED results in effective pain relief in patients with acute
      traumatic and non-traumatic pain, chronic non-cancer and cancer pain, and in patients with
      opioid-tolerant pain by virtue of providing anti-hyperalgesia, anti-allodynia, and
      anti-tolerance (2-4). Two commonly utilized routes of SDK administration in the ED include an
      intravenous route (intravenous push dose or short infusion) and intranasal route.

      In the situation when intravenous access is not readily available or unobtainable, and
      intranasal route is not feasible, another non-invasive route of ketamine administration such
      as inhalation via Breath-Actuated Nebulizer (BAN) is coming into the play. The BAN allows a
      controlled patient-initiated delivery of analgesics in titratable fashion. Nebulized
      administration of ketamine has been studied in the areas of acute postoperative pain
      management (post-intubational sore throat), in anesthesia (pre-medication for general
      anesthesia,) and in managing cancer pain, and status asthmaticus therapy.

      However, our research team has published a case series of 5 patients receiving nebulized
      ketamine for a variety of acute painful conditions and has recently completed a randomized
      double-blind trial of 120 adult patients that evaluated analgesic efficacy and safety of
      nebulized ketamine at three different dosing regimens for acute pain in the ED. Currently, we
      are conducting two additional studies evaluating the role of nebulized ketamine in pediatric
      ED and pre-hospital arena.

      In this study the investigators hypothesize that intravenous sub-dissociative-dose ketamine
      of 0.3 mg/kg will provide better analgesia at 30 min post-medication administration in
      comparison to nebulized ketamine administered at 0.75 mg/kg. The primary outcome of this
      trial is the comparative reduction in participant's pain scores at 30 minutes post medication
      administration.
    

Detailed description: 
      Design: This is a prospective, randomized, double-blind, double dummy trial comparing
      analgesic efficacy and safety of intravenous SDK administered at 0.3 mg/kg over 15 minutes to
      nebulized ketamine at 0.75mg/kg administered via BAN to patients presenting to the ED of
      Maimonides Medical Center with acute and chronic painful conditions. Upon meeting the
      eligibility criteria, patients will be randomized into two study groups: IV SDK and Nebulized
      K-BAN.

      Subjects: Patients 18 years of age and older presenting to the ED with acute and chronic
      painful conditions such as traumatic and non-traumatic abdominal, flank, back,
      musculoskeletal pain, headache, as well as exacerbation of chronic abdominal, musculoskeletal
      and neuropathic pain with a score of 5 or more on a standard 11- point (0 to 10) numeric
      rating scale and requiring parenteral analgesia as determined by the treating attending
      physician. Patients' screening and enrollment will be performed by study investigators and
      research assistants. All patients will be enrolled at various times of the day when study
      investigators will be available for patient enrollment and an ED pharmacist will be available
      for medication preparation

      Data Collection Procedures: Each patient will be approached by a study investigator for
      acquisition of written informed consent and Health Insurance Portability and Accountability
      Act authorization after being evaluated by the treating emergency physician and determined to
      meet study eligibility criteria. When English will not be the participant's primary language,
      a language- appropriate consent form will be used and non-investigator, hospital-employed,
      trained interpreters or licensed telephone interpreter will assist in acquisition of informed
      consent. Baseline pain score will be determined with an 11-point numeric rating scale (0 to
      10), described to the patient as "no pain" being 0 and "the worst pain imaginable" being 10.
      A study investigator will record the patient's body weight and baseline vital signs.

      The on-duty ED pharmacist will prepare either a breath-actuated nebulizer with a dose of 0.75
      mg/kg or an infusion dose of IV SDK at 0.3 mg/kg in 100 ml normal saline bag according to the
      predetermined randomization list, which will be created in SPSS (version 24; IBM Corp,
      Armonk, NY) with block randomization of every 10 participants. All participants will receive
      a corresponding placebo in order to maintain double-dummy design: the subjects randomized to
      receive IV SDK will also receive nebulized saline via BAN, and the subjects receiving K-BAN
      will also receive an IV infusion of Normal Saline over 15 minutes. The medication will be
      delivered to the treating nurse in a blinded fashion who will set up an infusion pump with a
      run time of 15 minutes. The nebulization of active drug and placebo via BAN will have a
      minimum time of 5 min and maximum time of 15 min.

      Study investigators will record pain scores, vital signs, and adverse effects at 15, 30, 60,
      90, and 120 minutes. If patients reported a pain numeric rating scale score of 5 or greater
      and requested additional pain relief, intravenous morphine at 0.1 mg/kg will be administered
      as a rescue analgesic.

      The preparing ED pharmacist, research manager, and statistician will be the only ones with
      knowledge of the study arm to which each participant would be randomized. Treating providers,
      participants, and the data collecting research team will be blind to the medication route
      received.

      All data will be recorded on data collection sheets, including patients' sex, demographics,
      medical history, and vital signs, and entered into SPSS (version 24.0; IBM Corp) by the
      research manager. Development of the randomization list, confirmation of written consent
      acquisition for all participants, and statistical analyses will be conducted by the research
      administrator and/or statistician who will work independently of any data collection.

      Patients will be closely monitored for any change in vital sings and for adverse effects
      during the entire study period (up to 120 minutes) by study investigators. Common adverse
      effects that are associated with sub-dissociative dose ketamine are felling of unreality,
      dizziness, nausea, vomiting, and sedation.
    

Intervention name(s): Ketamine via Intravenous; Ketamine via BAN
Intervention type(s): Drug; Drug
Intervention description(s): Ketamine administration in sub-dissociative doses; Ketamine administered via Breath-Actuated Nebulizer (BAN)
Intervention MeSH terms: Ketamine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Treatment