Whole Body Periodic Acceleration on Blood Lactate and Recovery
Condition: Acidosis, Lactic
MeSH terms: Acidosis; Acidosis, Lactic
Study type: Interventional

Summary: 
      Whole-body periodic acceleration (WBPA) is a new, non-invasive, and promising therapy for a
      diverse and growing list of disorders including cardiovascular disease 6. During WBPA,
      patients lie in the supine position on a bed that is capable of translating back and forth
      parallel to the ground, along the head-to-foot axis of the patient. Thus, this treatment is
      best described as a form of "passive exercise." The frequency of the translation (up to 180
      cycles/minute; cpm) as well as the distance traveled (2-24mm) by the bed can be adjusted by
      the patient or health care professional.

      The science behind the therapeutic effects of WBPA still remains largely unknown.

      The objective of this study is to determine if WBPA may be used as an effective way to reduce
      lactic acid concentrations during recovery after intense exercise more rapidly than
      previously established methods.
    

Detailed description: 
      Each visit Subjects will perform a graded treadmill exercise test. They will rest for 10
      minutes. At the end of the rest period, resting vital signs (HR and BP) will be recorded as
      well as resting oxygen consumption (VO2). Resting capillary blood sample will be taken and
      analyzed by the Accutrend portable lactate analyzer to measure blood lactate levels. The
      cardiac and metabolic recordings will be measured by PFT GX machine (Medgraphics Ultima; St.
      Paul, Minnesota) that will record VO2, VCO2, RER (respiratory exchange ratio), Ve. Heart Rate
      will be monitored by a Polar® HR monitor. This machine is attached to a motorized treadmill
      with handrails. Each subject will perform a Modified Bruce Protocol which consists of a
      maximum of five 3-minute stages. The criteria set for peak exercise is one of the following:
      1) 90% of THR; 2) a plateau of oxygen uptake is indicated; 3) if the subject is unable to
      maintain the pace of the treadmill; 4) an RER of over 1.0 and/or 5) a plateau in Ve (3).
      Additionally, the American College of Sports Medicine (ACSM) guidelines for terminating
      exercise testing will be followed(American College of Sports Medicine).

      TIMELINE of PROCEDURES

      The following recoveries will be tested on 3 separate days:

      Visit 1 The subject will walk at 30-40 % of V02 max for the next 20 minutes on the treadmill
      after peak exercise. Blood lactate will be taken at minute 20.

      Visit 2 The subject will be taken off the treadmill after a 3 minute walk and placed on the
      WBPA bed. The horizontal displacement will be held constant at 14 mm, and cycles/min will be
      held constant at 140. There is a footboard where the subjects feet are strapped in while
      wearing their own shoes. The platform moves in a repetitive motion from head-to- foot
      imparting mild periodic inertial forces in the subject's spinal axis (pGz). Blood lactate
      will be taken at minute 20.

      Visit 3

      The subject will be taken off the treadmill after a 3 minute walk and asked to sit in a chair
      for 20 minutes. Blood lactate will be taken at minute 20.
    

Intervention name(s): Whole Body Periodic Acceleration
Intervention type(s): Device
Intervention description(s): A bed that translates back and forth at different frequencies while the subject lies supine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science