Appetite and Exercise in Breast Cancer Survivors
Condition: Overweight; Breast Cancer; Obesity
MeSH terms: Breast Neoplasms; Overweight
Study type: Interventional

Summary: 
      The overall aim of this research is to investigate the acute effects of resistance exercise
      (REx) on the hormonal and behavioral indices of energy balance regulation in breast cancer
      survivors. This pilot study is designed to provide preliminary data to support future
      exercise interventions with more comprehensive energy balance profiling.
    

Detailed description: 
      After screening, eligible and consented participants will complete baseline evaluations of
      REE, body composition, and subjective questionnaires to assess energy balance. Eligible and
      interested individuals will attend an exercise familiarization session in the two weeks
      before the initial study visit. Individuals will then be randomized to either sedentary
      control/REx or REx/sedentary control in a 1:1. A washout period of approximately 7-14 days
      will separate testing sessions.

      A randomized cross-over short-term study design was chosen to assessment to profile appetite,
      energy intake, and physical activity in controlled and free-living settings while also
      reducing participant burden (as opposed to a long-term intervention). Participants will serve
      as their own controls, thereby circumventing inter-individual variation in physiology that
      may confound results. It is anticipated that responses to acute exercise will be amplified in
      chronic interventions and may therefore be used as a basis for generating hypotheses on the
      regulation of certain energy balance components. The study will end after the completion of 3
      days of dietary intake recall and physical activity measurement for the last participant.
    

Intervention name(s): REx Condition First; Sedentary Control Condition First
Intervention type(s): Behavioral; Behavioral
Intervention description(s): REx condition: Participants will complete a whole-body REx workout consisting of 1-set to failure (e.g. RPE of 9-10 on 10-point scale on final reps) on 12 exercises in the Exercise Research Laboratory (located in the CTRC), with a 3-minute rest between exercises. Participants will complete the following exercises: leg press; leg extension; leg curl; hip abduction; hip adduction; chest press; overhead press; seated row; overheard pulldowns and assisted triceps dips on Cybex resistance equipment; barbell calf raises on a Smith machine; and dumbbell biceps curls. Resistance for the REx trial will be determined based on the exercise familiarization session. Specifically, we will target a resistance level needed for each participant to complete ~12-15 repetitions per exercise, using proper form, with an RPE of 9-10 on a 10-point scale on final reps. This protocol eliminates the need for max testing in order to set an exercise protocol off of a specific intensity based on % of 1RM.; Sedentary control condition: Participants will sit quietly in a seated position for the entire duration of this condition.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Individuals will be randomized to either sedentary control/REx or REx/sedentary control in a 1:1 manner using online software (http://www.randomization.com).
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Appetite; Energy intake; Energy metabolism; Nutrition; Exercise