bioihbjkbjnl/mcl2 huggingface dataset:
Mechanisms of Arm Recovery in Stroke Patients With Hand Paralysis
Condition: Stroke; Hemiparesis; Cerebral Vascular Accident; Stroke, Ischemic
MeSH terms: Stroke; Paralysis; Paresis; Ischemic Stroke
Study type: Interventional

Summary: 
      This study examines the effect of non-invasive brain stimulation targeting different brain
      areas on movement of the affected arm post-stroke. Participants will receive stimulation to
      each of 3 different brain areas combined with a session of arm exercise.
    

Detailed description: 
      Small improvements in affected arm movement can be made with intensive physical practice.
      These improvements could potentially be enhanced by combining non-invasive brain stimulation
      with practice.

      To develop such an intervention, it is necessary to understand which brain areas should be
      stimulated in which types of patients. It is probably more beneficial to target one side of
      the brain vs. the other, for example, depending on the characteristics of the stroke.

      This study will examine the effect of stimulating one side of the brain vs. the other on the
      amount of improvement that occurs from physically practicing functional arm movements.
    

Intervention name(s): Unaffected Transcranial Magnetic Stimulation; Affected Transcranial Magnetic Stimulation; Control Transcranial Magnetic Stimulation
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): Non-invasive brain stimulation to unaffected hemisphere site prior to practice; Non-invasive brain stimulation to affected hemisphere site prior to practice; Non-invasive brain stimulation to control site prior to practice
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Each participant will receive stimulation targeting each brain area. The order in which the stimulation sites are targeted for each participant is randomized and there is a washout period of several weeks between each treatment.
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: arm; rehabilitation; non-invasive brain stimulation; transcranial magnetic stimulation; upper extremity
Effect of Intermittent Versus Continuous Energy Restriction on Compensatory Mechanisms Activated During Weight Reduction
Condition: Obesity
MeSH terms: Weight Loss
Study type: Interventional

Summary: 
      Obesity has become a global epidemic with huge public health implications. Although clinical
      significant weight loss can be achieved by a combination of diet and behavioral modification,
      strong metabolic adaptations, with increased appetite and suppressed energy expenditure, are
      activated, which compromise weight loss maintenance and increase the risk of relapse. The aim
      of this project is to compare the effects of intermittent versus continuous energy
      restriction on the compensatory responses previously described using two low calory diets,
      with a similar macronutrient distribution. More specifically, this study will analyze, in the
      short-term, if an intermittent energy restricted diet is associated with less appetite and
      low reduction in energy expenditure when compared with a continuous energy restricted diet.
      This project can bring large practical benefits concerning the design of weight loss programs
      to minimize weight relapse.
    


Intervention name(s): Intermittent energy restricted diet; Continuous energy restricted diet
Intervention type(s): Behavioral; Behavioral
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Weight loss; Intermittent energy restriction; Metabolic compensation; Diet therapy
Double Blind Placebo Controlled Study on the Effect of Extracorporal Shock Wave Therapy on Erectile Dysfunction
Condition: Erectile Dysfunction
MeSH terms: Erectile Dysfunction
Study type: Interventional
Phase: Phase 3

Summary: 
      This study aims to evaluate the effect of shockwave therapy on erectile dysfunction on
      patients responding to PDE5i therapy in a sham controlled randomized double blind manner.
    

Detailed description: 
      This study aims to evaluate the effect of a 12-session low intensity shockwave therapy
      protocol for patients with erectile dysfunction.
    

Intervention name(s): "MEDISPEC" treatment probe; "MEDISPEC" Sham Probe; "MEDISPEC" Low intensity shock waves; Sham
Intervention type(s): Device; Device; Device; Device
Intervention description(s): 300 shocks in 5 different anatomical locations of the penis.; Sham probe applied same as treatment probe without energy; Treatment parameters will be as follows: Intensity: 0.09 mj/mm2 ,300 shocks per site, on 5 penile anatomical sites. Total number of shock waves: 1500/ session Frequency of 120/min; Probe does not deliver energy but creates same noise and sensation of active probe
Other intervention name(s): VASCUSPEC; VASCUSPEC; VASCULOSPEC; Vasculospec
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Erectile dysfunction; Low Intensity Shock Wave
A Randomized Evaluation of First-dollar Coverage for Post-MI Secondary Preventive Therapies
Condition: Myocardial Infarction; Coronary Artery Disease
MeSH terms: Coronary Artery Disease; Myocardial Infarction; Infarction
Study type: Interventional
Phase: Phase 4

Summary: 
      The objective of this randomized trial is to evaluate the effect of providing full
      prescription drug coverage (i.e. no co-pays, co-insurance or deductibles) for statins,
      beta-blockers, angiotensin converting enzyme inhibitors and angiotensin II receptor blockers
      to patients recently discharged from hospital after acute myocardial infarction.
    


Intervention name(s): Full drug coverage; Usual coverage
Intervention type(s): Other; Other
Intervention description(s): Patients randomized to first-dollar coverage will have their pharmacy benefits changed so that they have no out-of-pocket costs for any beta-blocker, angiotensin converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) antagonist, or statin for every subsequent prescription after randomization. All co-pays and co-insurance will be waived at the point of care (i.e. pharmacy) as will any contribution that the cost of these drugs contributes to a patient's deductible; Patients randomized to usual coverage will have no change in their existing benefits
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Health Services Research
Keywords: myocardial infarction; secondary prevention; health insurance; cost-sharing
The Safety and Effectiveness of Zidovudine Plus Adefovir in HIV-Infected Patients
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Interventional
Phase: Phase 1

Summary: 
      To study the safety, tolerance, pharmacokinetics, and anti-HIV effects of combination
      zidovudine (AZT) and PMEA (adefovir) therapy.
    

Detailed description: 
      Patients receive AZT daily and intravenous PMEA three times weekly for 4 weeks. An MTD will
      be defined for this regimen.
    

Intervention name(s): Adefovir; Zidovudine
Intervention type(s): Drug; Drug
Intervention MeSH terms: Zidovudine; Adefovir
Primary purpose: Treatment
Keywords: Drug Therapy, Combination; Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Zidovudine; Adenine
Combined Treatment for Cocaine-Alcohol Dependence - 1
Condition: Alcohol Dependence; Cocaine Dependence
MeSH terms: Alcoholism; Cocaine-Related Disorders
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to examine whether Naltrexone and cognitive behavioral therapy
      can be helpful in patients who want to stop using cocaine and alcohol.
    

Detailed description: 
      This is a randomized, double blind placebo-controlled trial to examine the role of Relapse
      Prevention (RP) and Contingency Management (CMP) combined with Naltrexone (NTX) for the
      treatment of cocaine-alcohol dependence. Patients will be randomly assigned to NTX (100mg/d)
      or placebo combined with one of two psychotherapy conditions (RP or RP +CMP). Following a
      standardized consent and intake procedure patients will participate in a 12-week trial with
      thrice weekly visits. Manual-guided RP therapy will be delivered in weekly 60-minute
      individual sessions. CMP will be based on cocaine-negative urine screens and negative breath
      alcohol tests. Follow-up assessments will be conducted at 3 and 6 months after treatment.
    

Intervention name(s): Naltrexone; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Naltrexone; Placebo
Other intervention name(s): Naltrexone 100mg/day
Intervention MeSH terms: Naltrexone
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Alcohol Dependence; Cocaine Dependence
Supplementation With Cholecalciferol in Dialysis Patients
Condition: Chronic Kidney Disease
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic
Study type: Interventional
Phase: Phase 2

Summary: 
      Hypovitaminosis D is highly prevalent among patients with chronic kidney disease, especially
      in those undergoing dialysis. The loss of protein to the dialysis solution seems to
      contribute significantly to the reduced serum levels of vitamin D in these patients. As a
      result of the disease and the dialysis procedure, there is high prevalence of chronic
      inflammation and high risk of infections. There is evidence in other populations, that
      vitamin D has immunomodulatory effects by stimulating the production of cathelicidin, an
      antimicrobial peptide and suppressing the production of proinflammatory cytokines. Thus, this
      study aims to investigate the effects of cholecalciferol supplementation on immunological
      markers in patients in hemodialysis and peritoneal dialysis with hypovitaminosis D . This is
      a randomized, double-blind, placebo-controlled trial in which patients who have vitamin D
      deficiency [25 (OH) D <20 ng / mL] will be allocated to the intervention group
      (cholecalciferol) or control (placebo). Patients will receive supplemented 100,000 IU / week
      cholecalciferol a period of 12 weeks. Before and after the intervention will be determined
      25(OH)D, cathelicidin, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive
      protein serum. In monocytes, we will evaluate cathelicidin, IL-6 and TNF-α, 25(OH)D receptor
      and α 1-hydroxylase enzyme expression.
    


Intervention name(s): Cholecalciferol; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): 100,000 IU/week for 12 weeks; 100 drops/ week for 12 weeks
Other intervention name(s): Vitamina D3
Intervention MeSH terms: Cholecalciferol; Vitamin D
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Cholecalciferol; Kidney diseases
Lung Ultrasound in the Evaluation of Pneumothorax Size
Condition: Pneumothorax
MeSH terms: Pneumothorax
Study type: Observational

Summary: 
      Background

        -  Assessment of the percentage of lung collapse is crucial in the therapeutic
           decision-making of pneumothorax.

        -  The methods normally used to this purpose are radiological. Computerized tomography scan
           (CT) is highly accurate because it allows the exact evaluation of the volume of the air
           layer. However, in clinical practice assessment of the volume of pneumothorax mainly
           relies on the measurement of the inter-pleural distance at conventional chest
           radiography (CXR). This latter method is inaccurate.

        -  Lung ultrasound is a new method highly accurate in the first diagnosis of pneumothorax,
           with a sensitivity superior to CXR and similar to CT in case of traumatic pneumothorax.

        -  The scientific community is actually debating about the usefulness of lung ultrasound in
           the quantification of pneumothorax []. Lung ultrasound can assess the superficial
           extension of the pneumothorax, but cannot evaluate its volume.

      Aim

        -  Main purpose of the study is to compare measurement of the superficial extension of
           pneumothorax on the chest wall obtained by lung ultrasound, to the evaluation of the air
           volume performed by CT in patients with pneumothorax.

        -  The main hypothesis of the study is that the cut-off between small (<11% of lung
           collapse) and large (>11% of lung collapse) pneumothorax can be identified by a lung
           ultrasound evaluation of the superficial extension of pneumothorax.

        -  Second purpose of the study is to compare the accuracies of lung ultrasound and CXR in
           predicting the volume of pneumothorax assessed by CT.

        -  Secondary hypothesis is that lung ultrasound demonstrates greater accuracy in the
           prediction of volume of pneumothorax and percentage of lung collapse.

      Methods

        -  Patients with a diagnosis of pneumothorax confirmed at CT are prospectively enrolled and
           submitted to lung ultrasound within 20 min from the CT study.

        -  Different locations of the sonographic "lung point" on the chest wall (i.e. the point on
           the chest wall where the sonographic pattern of the normally aerated lung alternates
           with the pathologic sonographic pattern of pneumothorax) are compared with different
           volumes of pneumothorax measured by CT.
    


Observational model: Case-Only
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients from the Emergency Department Patients admitted to the Hospital Outpatients from
        the Radiology Department who undergo invasive thoracic procedures
      
Keywords: Pneumothorax; Lung ultrasound; Chest sonography
A Comparison of Three Methods of Hemoglobin Monitoring in Pediatric Patients Undergoing Major Surgery
Condition: Child
Study type: Interventional

Summary: 
      Investigators compare the accuracy of the SpHb and hemocue with blood Hb levels
    

Detailed description: 
      The goal of the study is to compare 3 methods of hemoglobin measurement in pediatric patients
      undergoing major surgery. During general anesthesia investigators will measure and compare at
      different periods of time blood hemoglobin levels obtained from a radial artery catheter with
      2 non invasive methods of measurement using hemocue and SpHb
    

Intervention name(s): blood measurement; pulse co-oxymeter (SpHb); hemoCue
Intervention type(s): Device; Device; Device
Intervention description(s): Hemoglobin measurement; non invasive method of hemoglobin measurement; non invasive method of hemoglobin measurement
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: major pediatric surgery; hemoglobin measurement
Symfony Intraocular Lens Retrospective Chart Review
Condition: Cataract
MeSH terms: Cataract
Study type: Observational

Summary: 
      Retrospective chart review of patients with pre-existing ocular pathology who underwent
      cataract surgery with implantation of the Symfony IOL.
    

Detailed description: 
      This was a retrospective chart review conducted at a single US clinical site. Chart review
      was conducted by John Odette, MD and research assistants. Eligible charts were identified via
      a clinic database search of cataract surgeries with IOL implantation of the Symfony IOL
      during the stated date range. Eligible charts included those of patients 18 to 90 years of
      age who underwent Femto Laser Assisted Cataract Surgery (FLACS) with implantation of a
      Symfony IOL. Charts were excluded for lack of postoperative follow-up or if Symfony IOL was
      not implanted. All qualifying patient charts were examined and further classified into 2
      groups: (1) eyes with glaucoma; and 2) eyes without glaucoma. Visual acuity was evaluated for
      patients who underwent cataract surgery with implantation of the Symfony IOL from 09/1/2016
      to 05/31/2018. Postoperative evaluations at Month 2 included mean monocular uncorrected
      visual acuity at near (UNVA) at 40 cm, far distance (UDVA) at 20 ft, and with best correction
      (CDVA). Outcomes were also compared for toric IOLs versus spherical IOL.
    

Intervention name(s): Symfony IOL
Intervention type(s): Device
Intervention description(s): Implantation of Intraocular lens with extended depth of focus.
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Adult patients (18-90 years old) in need of cataract surgery.
      
Keywords: Cataract surgery; Glaucoma; Retinopathy; Intraocular Lens
TDENV PIV and LAV Dengue Prime-boost Strategy
Condition: Dengue
MeSH terms: Dengue
Study type: Interventional
Phase: Phase 1

Summary: 
      The potential synergistic effect of administering 2 dengue vaccine candidates that were
      previously shown to be safe and immunogenic in humans will be evaluated in this study. A
      prime-boost study of tetravalent dengue virus purified inactivated vaccine (TDENV-PIV) with
      alum and tetravalent dengue live attenuated virus (TDENV-LAV) vaccine Formulation 17 (F17)
      will gather data to help better understand the human immune response to dengue vaccination
      and infection.
    


Intervention name(s): TDENV-LAV; TDENV-PIV 4 µg + alum adjuvant
Intervention type(s): Biological; Biological
Intervention description(s): 0.5 mL of the post-transfection LAV F17 vaccine; 0.5 mL of DENV serotypes 1-4 (4 µg / serotype) in alum adjuvant
Other intervention name(s): TDENV-LAV F17; Tetravalent dengue live attenuated virus formulation 17; Tetravalent dengue virus purified inactivated vaccine with alum adjuvant
Intervention MeSH terms: Aluminum Hydroxide; Aluminum sulfate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: dengue fever; dengue
To Test The Relative Bioavailability Of PF-04191834 When Dosed As An Immediate Release Tablet Compared With Solution Following Single And Multiple Dosing
Condition: Asthma
Study type: Observational

Summary: 
      To test the relative bioavailability of PF-04191834 when dosed as an Immediate Release tablet
      compared with solution following single and multiple dosing.
    


Intervention name(s): PF-04191834
Intervention type(s): Drug
Intervention description(s): PF-04191834. 100mg Immediate Release Tablets or oral suspension
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        young, healthy male volunteers
      
Biospecimen description: 
      whole blood, plasma, urine, saliva
Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology During IVF/ICSI
Condition: In Vitro Fertilization; Intracytoplasmic Sperm Injection; Infertility
MeSH terms: Infertility
Study type: Interventional
Phase: Phase 4

Summary: 
      Selection of developmentally competent oocytes enhances IVF efficiency. Usually, oocyte
      quality is determined based on its nuclear maturation and the presence of specific
      cytoplasmic and extracytoplasmic morphologic features. Gonadotropin-releasing hormone
      agonists (GnRH Agonists) and gonadotropin-releasing hormone antagonists (GnRH Antagonists)
      are used during controlled ovarian stimulation (COS) protocols in order to prevent premature
      luteinizing hormone (LH) surge and premature ovulation. However, GnRH receptors are also
      expressed in extra-pituitary tissues such as ovary, but it is still unknown whether the type
      of GnRH analogues used during COS could affect the oocyte morphology, especially with the
      limited and conflicted currently available data. Thus, we are conducting this prospective,
      non-randomised, open-label, clinical trial to compare the effects of two pituitary
      suppression regimens; GnRH Agonist-Long Protocol and GnRH Antagonist-Flexible Protocol on
      oocyte morphology during IVF/ICSI.
    


Intervention name(s): Triptorelin acetate; Cetrorelix; recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin; Human Chorionic Gonadotropin (hCG)
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): 0.05-0.1 mg subcutaneously (SC) once daily from the mid-luteal phase (day 21) of the cycle until the day of ovulation triggering.; 0.25 mg subcutaneously (SC) once daily starting from the day detecting a leading follicle diameter ≥ 14 mm until the day of ovulation triggering.; Dosage adjustment according to the ovarian response.; Ovulation will be triggered by the administration of 10,000 IU of human chorionic gonadotropin when at least three follicles become more than 16-17 mm.
Intervention MeSH terms: Triptorelin Pamoate; Chorionic Gonadotropin; Cetrorelix; Menotropins
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: GnRH Agonist; GnRH Antagonist; Oocyte morphology; Assisted reproduction technique; In Vitro Fertilization; Intracytoplasmic sperm injection
Fermented Dairy Products and The Metabolic Syndrome
Condition: Overweight or Obesity; Metabolic Syndrome
MeSH terms: Overweight; Metabolic Syndrome; Syndrome
Study type: Interventional

Summary: 
      The study will be conducted as a randomized controlled trial with four parallel arms
      including four dairy products. We will investigate the health effects of including yogurt in
      the diet through a 16-weeks intervention period among 100 volunteering males with symptoms of
      the metabolic syndrome. The study has a total duration of 20 weeks as a wash out period of
      four weeks will be initiated prior to the intervention.
    


Intervention name(s): Regular whole milk; Yogurt with live bacteria; Yogurt with inactivated bacteria; Acidified whole milk
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): 400 g/day of regular whole milk; 400 g/day of yogurt with live bacteria; 400 g/day of yogurt with inactivated bacteria; 400 g/day of yogurt with acidified whole milk
Other intervention name(s): Dairy product; Milk; Fermented dairy product; Yogurt; Fermented dairy product; Yogurt; Dairy product
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: 16-week parallel randomized controlled trial
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Dairy; Liver fat; Glucose metabolism