bioihbjkbjnl/mcl2 huggingface dataset:
Individually Tailored Web-based Cbt for Eating Disorders and the Role of Knowledge Acquisition
Condition: Eating Disorders; Bulimia
MeSH terms: Bulimia; Feeding and Eating Disorders
Study type: Interventional

Summary: 
      Background: Previous studies on Internet-based treatment with eating disorders have shown
      promising results.

      Objective: The first aim of this study was to investigate the effects of a tailored therapist
      guided internet-based treatment for individuals with eating disorders. The second aim was to
      examine the role of knowledge acquisition.

      Method: 138 participants were recruited. Screening consisted of online questionnaires
      followed by a telephone interview. A total of 92 participants were included after a
      semi-structured diagnostic interview and randomized to an 8 week treatment program (n=46) or
      to a control condition (n=46). Treatment consisted of individually prescribed cognitive
      behaviour therapy text modules in conjunction with online therapist guidance. The control
      group consisted of a waitlist who later received treatment.
    

Detailed description: 
      As above
    

Intervention name(s): Internet-delivered CBT
Intervention type(s): Behavioral
Intervention description(s): Guided internet treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: emotional eating; restrictive eating; body dissatisfaction
The Impact of Patient Motivational Dialogue (PMD) on Patient Self-advocacy for Hand Hygiene
Condition: Hand Disinfection
Study type: Interventional

Summary: 
      This exploratory cross sectional cohort study will evaluate the feasibility and fidelity of
      using an innovative strategy, the Patient Motivational Dialogue (PMD)/PMDPlus that will
      intentionally motivate and encourage the patient toward self-advocacy for their Health Care
      Professional's (HCP's) hand hygeine (HH) adherence.
    

Detailed description: 
      This study will be implemented with two volunteer innovation champion physicians, one in
      radiation oncology and one in the chemotherapy oncology clinic. If other physicians begin to
      use the PMD/ PMDPlus in their clinics, the initiation will be considered a positive
      indication of feasibility and fidelity.

      New patients will be enrolled in the study starting September 2016 until the sample size
      reaches 30 patients per clinic (n=60). Each patient will be followed in each clinic visit
      longitudinal through March 2017 or until discharged from the clinic treatment depending on
      which comes first. PMD will be administered in the first clinic visit followed by the PMDPlus
      each visit thereafter to ensure an adequate treatment dose. The PMD is estimated to take
      about two minutes of the initial clinic visit and the PMDPlus is estimated to take about one
      minute of the follow-up clinic visit.

      The following steps will be taken based on the innovation decision model:

        1. The PI will instruct the physicians, or designee in the use of the PMD/PMDPlus. Script
           cards with the PMD/PMDPlus will be provided to each physician. The physician will be
           instructed in use of PMD at the initial visit and the PMDPlus every follow-up clinic
           visit thereafter until discharge from the clinic.

        2. A HCP survey will be conducted pre-intervention asking the HCP: "Has a patient or family
           ever ask you to clean your hands? If yes, the HCP will be asked to describe the
           situation.
    

Intervention name(s): PMD; PMDPlus
Intervention type(s): Other; Other
Intervention description(s): A script used to train the physician to engage with the patient in the topic of hand hygiene compliance used on the initial visit.; A script used to train the physician to engage with the patient in the topic of hand hygiene compliance on follow up visits
Other intervention name(s): Patient Motivational Dialogue; Patient Motivational Dialogue Plus
Intervention model: Single Group Assignment
Intervention model description: Subjects will be included from two oncology clinics, one in radiation oncology and one in chemotherapy oncology
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Motivation, hand hygiene
Gene Expression Profiles in Muscle After Immunisation
Condition: Healthy
Study type: Interventional

Summary: 
      This clinical study is part of the BIOVACSAFE project which is funded by the Innovative
      Medicine Initiative. In this study we will take a small muscle biopsy in order to identify
      any differences in the response around the actual site of injection compared with responses
      we measure in blood at the same time.
    


Intervention name(s): Fluad; Fendrix; Placebo
Intervention type(s): Biological; Biological; Biological
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Basic Science
Pentoxifylline as an Adjunct to Citalopram in Adult Patients With Major Depressive Disorder
Condition: Major Depressive Disorder
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      The aim of this study is to test if combining the antidepressant Citalopram with
      Pentoxifylline (PTX), a medicine with anti-inflammatory and phosphodiesterase inhibitory
      properties, enhanced antidepressant efficacy in adult patients with major depressive disorder
      (MDD) when compared to Citalopram alone.
    

Detailed description: 
      According to mounting evidence, inflammation and phosphodiesterase (PDE) pathways may play a
      role in the pathogenesis of psychiatric diseases such as MDD. PTX is a phosphodiesterase
      inhibitor and has anti-inflammatory and antioxidant effects. Therefore, it has been
      hypothesized that MDD patients taking combined administration of the Citalopram, a Selective
      Serotonin Reuptake Inhibitor (SSRI), and PTX would show a higher improvement in depression
      symptoms. The relationship between the Hamilton Depression Rating Scale-17 items (Ham-D-17)
      score and various biological markers and their potential role in the therapeutic outcome of
      MDD will be assessed.
    

Intervention name(s): Citalopram (tablet) 20 mg + Pentoxifylline (tablet) 400Mg; Citalopram (tablet) 20 mg + Placebo (tablet)
Intervention type(s): Drug; Drug
Intervention description(s): Selective serotonin reuptake inhibitor (SSRI) + phosphodiesterase inhibitor with anti-inflammatory properties; Selective serotonin reuptake inhibitor (SSRI) + placebo
Intervention MeSH terms: Pentoxifylline; Dexetimide; Citalopram; Escitalopram
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Safety Study of Chinese Herbal Therapy to Treat Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to determine the safety of an anti-asthma herbal medicine
      intervention (ASHMI) in adult asthmatics and to see what effects ASHMI has on certain parts
      of the immune system.
    

Detailed description: 
      Asthma is a major public health problem worldwide, particularly in westernized societies and
      has continued to increase in prevalence over the past two decades. Inhaled corticosteroids
      have become the first-line treatment for persistent asthma even though significant side
      effects have been reported. New asthma medications, including leukotriene inhibitors and
      anti-IgE, have shown only marginal benefits. Patients have increasingly turned to
      complementary and alternative medicine (CAM) for treatment of their asthma, despite the
      uncertainty of its benefits due a lack of well-controlled scientific studies.

      We have developed a Chinese herbal formula composed of 3 herbs called ASHMI. It has been
      previously shown in murine studies that ASHMI (a formula containing Ling Zhi, Ku Shen and Gan
      Cao) has therapeutic effects on the major pathogenic mechanisms of asthma-airway
      hyperreactivity, pulmonary inflammation, and airway remodeling, as well as a down-regulating
      of TH2 response. A subsequent study in 91 asthmatic patients in Weifang, China found ASHMI to
      be a safe and effective alternative to prednisone for treating asthma and exhibited a
      beneficial effect on TH1 and TH2 balance. Based on these preliminary studies, we hypothesize
      that ASHMI will be a safe medication in atopic patients with asthma and will lead to
      identifiable changes in serum immunologic markers.
    

Intervention name(s): Anti-Asthma Herbal Medical Intervention (ASHMI)
Intervention type(s): Drug
Intervention description(s): We propose to test 3 daily doses in which 2,4, or 6 ASHMI or placebo capsules will be administered orally twice daily (BID) for 7 days.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Chinese Herbal Therapy; Asthma; Investigational new drug (IND); Complementary and Alternative Medicine
Compare Celecoxib and Ibuprofen Sr In The Management Of Acute Pain Post Orthopedic Or Gynecological Surgery
Condition: Pain, Postoperative
MeSH terms: Pain, Postoperative; Acute Pain
Study type: Interventional
Phase: Phase 3

Summary: 
      To validate the analgesic efficacy and safety of celecoxib compared with ibuprofen SR in the
      management of acute pain post orthopedic or gynecological surgery
    


Intervention name(s): celecoxib and ibuprofen SR
Intervention type(s): Drug
Intervention MeSH terms: Ibuprofen; Celecoxib
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Pharmacokinetic Interactions Between Buprenorphine and Tipranavir/Ritonavir
Condition: HIV Infections
MeSH terms: HIV Infections
Study type: Interventional

Summary: 
      The main purpose of this study is to examine the effect of tipranavir combined with
      ritonavir, medications for the treatment of HIV-infection, on buprenorphine/naloxone (BUP) in
      people who have been receiving the same dose of buprenorphine/naloxone for at least 3 weeks
      before study entry.
    

Detailed description: 
      A large number of people with HIV-infection obtained HIV through injection drug use. Some of
      these people are currently being treated with buprenorphine/naloxone (BUP) for their
      addiction and with medications for HIV infection. Tipranavir is a medication that was
      recently approved by the Food and Drug Administration (FDA) for the treatment of
      HIV-infection. Tipranavir is given in combination with another HIV medication, ritonavir.
      Tipranavir acts by making it more difficult for the virus that causes AIDS to multiply and
      cause more damage to the immune system. Ritonavir acts by increasing the amount of tipranavir
      available to fight HIV.

      Earlier studies looking at the combination of BUP and HIV medications have shown that BUP and
      some HIV medications act differently when taken together. It is important to learn if taking
      BUP and HIV medications together results in changes in the blood level of either medication.
      If the HIV medication decreases the level of BUP in the blood, an individual taking BUP and
      HIV medications may experience symptoms of withdrawal ("dope sickness"), even while taking
      their usual dose of BUP. On the other hand, if BUP decreases the amount of HIV medication in
      the blood, then the HIV medication may be less effective in controlling HIV infection. It is
      therefore important to learn if tipranavir/ritonavir and BUP will affect each other when
      taken together.

      In order to learn about the effects of BUP on tipranavir/ritonavir, we will need to measure
      the amount of BUP in your blood for 24 hours after you have taken tipranavir/ritonavir and
      BUP together and then compare that to the amount of BUP in your blood when you are not taking
      tipranavir/ritonavir.
    

Intervention name(s): Buprenorphine, Tipranavir and ritonavir
Intervention type(s): Drug
Intervention description(s): After determining buprenorphine/naloxone pharmacokinetics over a 24-hour period, tipranavir/ritonavir and buprenorphine/naloxone will be coadministered for 7 days.
Intervention MeSH terms: Ritonavir; Tipranavir; Buprenorphine
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: HIV; Pharmacokinetics; Buprenorphine; Tipranavir; HIV Seronegativity
Evaluation of Diagnostic Methods and Dietary Treatment of Diabetic Gastroparesis
Condition: Diabetic Gastroparesis
MeSH terms: Gastroparesis
Study type: Interventional
Phase: Phase 2

Summary: 
      The objective of the study is in subjects with Insulin Treated Diabetes Mellitus type 1 or 2
      and gastroparesis:

        -  validate radiopaque markers with fluoroscopy with gastric scintigraphy method

        -  study the difference of metabolic control including the frequents of hypoglycaemia,
           gastrointestinal symptoms, quality of life and nutrition state during dietary treatment
           of food of small particle size compared with food of large particle size

        -  validate the radiopaque markers method and measurement of the blood glucose and
           gastrointestinal symptoms after a test meal, against the gastric scintigraphy

        -  determine if the function of gastric emptying can be improved after intervention
    


Intervention name(s): dietary treatment: food of small particle size; Validate X-ray diagnostic method.; Can the motility be improved; postprandial plasma glucose
Intervention type(s): Dietary Supplement; Radiation; Other; Biological
Intervention description(s): Subjects with diabetes mellitus and gastroparesis. Insulin treatment. Dietary treatment with food of small particle size.; Follow 20 radiopaque markers throw the ventricle by X-ray.; Registered the gastric emptying after intervention. Comparing the registrations at the beginning and at the end of the study.; Measure the blood glucose response and gastrointestinal symptoms after a test meal
Other intervention name(s): Randomized study; Diabetic gastroparesis; Dietary treatment:Food of small particle size; Metabolic control; Gastrointestinal symptoms; Quality of life; Nutrition status; Autonomic neuropathy; Radiopaque markers method; Gastric scintigraphy; motility; gastric emptying; improved gastric emptying; gastric emptying; plasma glucose response; metabolic control
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Diet; Dietary treatment; Particle size; Gastroparesis; Diabetes Mellitus
A Study in Schizophrenia Patients
Condition: Schizophrenia
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 2

Summary: 
      An inpatient/outpatient study to see if LY2140023 is better than placebo in acutely ill
      patients with schizophrenia.
    


Intervention name(s): Risperidone; Placebo; LY2140023
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Administered orally.; Administered orally.; Administered orally.
Intervention MeSH terms: Risperidone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Ultrasound Guided Adductor Canal Block Versus Femoral Nerve Block for Quadriceps Strength and Fall-risk
Condition: Quadriceps Muscle Weakness; Adductor Muscle Weakness; Fall Risk
MeSH terms: Muscle Weakness; Paresis; Asthenia
Study type: Interventional
Phase: Phase 4

Summary: 
      Our objective was to determine if an ultrasound guided ACB can preserve quadriceps strength,
      thus minimizing weakness of knee extension compared with ultrasound guided femoral nerve
      block. Our primary outcome was the percent of maximum voluntary isometric contraction (MVIC)
      of knee extension preserved at 30 mins after either an ACB or FNB. Secondary outcomes
      included MVIC of knee extension at 60 min, hip adduction at 30 and 60 mins, and assessment of
      fall risk with the Berg Balance Scale (BBS) at 30 minutes.
    


Intervention name(s): Ultrasound Guided Adductor Canal Block; Ultrasound Guided Femoral Nerve Block
Intervention type(s): Procedure; Procedure
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Identifying the Most Accurate Method for Predicting the Safe Depth of Orally Placed Neonatal Endotracheal Tubes (ETT).
Condition: Infant Showing No Response to Resuscitation; Ventilator Adverse Event; Apparent Life Threatening Event in Newborn and Infant
MeSH terms: Brief, Resolved, Unexplained Event
Study type: Observational

Summary: 
      Placing artificial airways in infants is often performed under emergent life-saving
      conditions, which necessitates a procedure that is both accurate and efficient. Intubations
      of the newborn are often necessary before an accurate weight can be reported and estimations
      are often inaccurate. The current national standard uses body weight to predict the
      appropriate tube depth yet this approach tends to place the tube too deep for the smallest
      and most vulnerable neonate; and placement accuracy of any size infant is only 50-70%. The
      consequence of malpositioned ETTs resulting from poor oxygenation, lung hyperinflation,
      pneumothoraces and death has been suggested to cost $20 to $54 million annually.

      The morbidity and the financial impact suggest an optimal and accurate approach to place ETT
      in neonates has not been identified. Other methods to estimate the proper depth of the
      orotracheal tube have shown promise yet no comparison studies have been performed.
      Identifying the most accurate method to safely place neonatal orotracheal tubes will improve
      placement precision and reduce adverse events and their associated costs.

      Hypothesis

      Compared to weight, sternal to xyphoid length and shoulder to elbow length, the nasal to
      tragus length will become the most accurate method for predicting the safe depth of orally
      placed neonatal endotracheal tubes.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Infants <72 hours of age and orally intubated
      
Keywords: Infant; Newborn; Neonate; Intubation; Neonatal resuscitation
Treatment of Depression in Adults
Condition: Depression
MeSH terms: Depression; Depressive Disorder
Study type: Interventional
Phase: Phase 4

Summary: 
      This study will determine how certain features of depressed individuals affect their
      responses to depression treatment.
    

Detailed description: 
      Major depression is a serious condition that can have devastating functional consequences.
      Although numerous depression studies have been conducted, understanding of how best to
      achieve long-term recovery remains limited. This study will assess the mood, personality,
      pharamcokinetic and genetic characteristics of depressed participants to determine the
      effects of these features on treatment response.

      This study will be conducted at two international treatment sites, including the University
      of Pittsburgh and the University of Pisa, Italy. Participants will be randomly assigned to
      receive either interpersonal psychotherapy (IPT) or escitalopram pharmacotherapy for a
      minimum of 32 weeks or approximately 8 months. Participants whose symptoms become stabilized
      will continue the initial treatment for another 6 months; those who do not will have the
      second treatment added to their regimen until remission occurs. Clinical evaluations and
      questionnaires will be used to assess participants.
    

Intervention name(s): Escitalopram; Interpersonal Psychotherapy; Escitalopram plus IPT
Intervention type(s): Drug; Behavioral; Other
Intervention description(s): Participants will receive escitalopram for a minimum of 32 weeks or approximately 8 months. Participants whose symptoms become stabilized will continue the initial treatment for another 6 months.; Participants will receive interpersonal psychotherapy (IPT) for 8 months and possibly an additional 6 months.; Participants whose symptoms become stabilized will continue the initial treatment for another 6 months. Those who do not will have the second treatment added to their regimen until remission occurs.
Intervention MeSH terms: Dexetimide; Citalopram; Escitalopram
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Psychotherapy; Depressive disorder; Antidepressive agents; Citalopram
Imagery Vividness and Arousal Responses to Prospective Imagery
Condition: Healthy
Study type: Observational

Summary: 
      Research has shown that mental imagery appears to carry emotion better than verbal
      communication. One way this can be noted is that emotional mental imagery trigger
      physiological arousal responses. These may be important for treatment techniques using mental
      imagery, such as imaginal exposure and imagery re-scripting. However, as the development of
      clinical applications increasingly considers the use of flashpoint imagery, i.e. mental
      imagery of short duration, it is of interest to examine whether also flashpoint imagery
      trigger arousal responses. This study examines the arousal response to flashpoint imagery of
      different valence (positive, negative, and neutral).

      Moreover, emerging evidence suggest that depressed individuals find it more difficult to
      produce mental imagery of positive future events (less accessible and vivid) than healthy
      controls. In addition, individuals with clinical anxiety appear to be able to produce imagery
      of negative future events more easily than healthy controls. This study explores whether
      these results can be noted also in sub-clinical symptoms of depression and anxiety, and if
      so, if they are accompanied with corresponding changes in arousal responses.
    

Detailed description: 
      This study takes part in a single session. Participants will produce flashpoint imagery of
      future events while skin conductance responses, imagery vividness ratings, valence and
      arousal ratings are collected. Participants will also fill in questionnaires on depression
      and anxiety symptoms, as well as a questionnaire measuring general propensity for mental
      imagery.
    

Intervention name(s): Prospective Imagery visualization task
Intervention type(s): Behavioral
Intervention description(s): Participant visualizes brief mental imagery of prospective situations of different valence (neutral, positive, negative).
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Healthy participants
      
Keywords: Mental Imagery; Skin conductance