bioihbjkbjnl/mcl2 huggingface dataset:
Cardiovascular and Muscular Adaptations to Recreational Soccer and Strength Training in Elderly Healthy 65-75-year-old Men
Condition: Adaptation Reaction
Study type: Interventional

Summary: 
      A one-year intervention study of 41 healthy elderly men aged 65-75-years.Of these, 24
      subjects are untrained men with no regular training activity for the last 5 years. After
      medical screening and pre-testing, they will be randomized into a football group (n=9), a
      strength-training group (n=9) or a sedentary control group (n=6). Additional 17 subjects are
      recruited from local football clubs and have been active football players for the last 40
      years. Training will be performed 3x1 hour per week and evaluation will take place after 0, 3
      and 12 months. Primary endpoints will be changes in cardiac and vascular structure and
      function measured by advanced echocardiography (tissue Doppler and speckle tracking imaging),
      and peripheral arterial tonometry (Endo---PAT device). Secondary endpoints will be evaluation
      of potential changes in VO2 max, blood pressure, muscle capillaries, lipid profile,
      circulating catecholamines, body composition, and insulin resistance.
    


Intervention name(s): physical training
Intervention type(s): Other
Intervention description(s): training
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Prevention
Keywords: cardiac; vascular; muscular; adaptations; soccer training; strength training
3 Dimensional Ultrasound in Comparison to Hysteroscopy in Myomas
Condition: Fibroid
MeSH terms: Leiomyoma
Study type: Observational

Summary: 
      • three-dimensional saline infusion sonohysterography (3D SIS) was performed in all cases. A
      sterile Cuscoe speculum was passed, the cervix visualized and cleaned with sterile
      chlorhexidine solution. A 3.3 mm soft plastic paediatric naso-gastric suction catheter was
      then passed through the cervix into the uterine cavity without grasping the cervix.
    

Detailed description: 
      The speculum was removed and a 5 MHz transvaginal 3D ultrasound probe inserted into the
      vagina (Voluson 730; KretzTechnik, Austria).
    

Intervention name(s): 3D Ultrasound; Hysteroscopy
Intervention type(s): Diagnostic Test; Diagnostic Test
Intervention description(s): Doing 3D ultrasound for diagnosis of submucous myoma; Doing hysteroscopy for diagnosis of submucous myoma
Observational model: Other
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Women between 20 and 60 years with abnormal uterine bleeding
Effects of Labetalol on Nicotine Administration in Humans - 14
Condition: Tobacco Use Disorder
MeSH terms: Tobacco Use Disorder
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to investigate the effects of labetalol in response to
      intravenous nicotine
    

Detailed description: 
      The purpose of this study is to determine whether labetalol, an alpha and beta adrenergic
      blocker, will block the subjective and physiological effects of intravenously administered
      nicotine in humans. A total of 12 subjects will participate in the double blind placebo
      controlled, outpatient study. Subjects will have 3 separate experimental sessions 3-9 days
      apart. On each of the experimental sessions, a single oral dose of low (100mg) or high dose
      of labetalol (200mg ), or placebo will be administered. Two hours after labetalol or placebo
      treatment, subjects will receive 15 variance grams nicotine base/kg intravenously. Several
      physiological endocrine and subjective measures will be obtained during the sessions. We
      propose that blockage of adrenergic receptors by labetalol will significantly block the
      physological and subjective effects of nicotine.
    

Intervention name(s): Labetalol
Intervention type(s): Drug
Intervention MeSH terms: Labetalol
Masking: Double
Primary purpose: Treatment
Inhibitory Control and Pediatric Weight Management
Condition: Overweight and Obesity
MeSH terms: Overweight
Study type: Interventional

Summary: 
      The purpose of this pilot study is to explore the benefits of supplementing the Kurbo online
      program with a cognitive training game (PolyRules!) among youth ages 7-13 with overweight or
      obesity.
    


Intervention name(s): Kurbo Only; Kurbo + PolyRules!
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Kurbo is a structured behavioral weight management program for youth that focuses on diet, physical activity and mindset skills and is based on the traffic light diet developed at Stanford University. The dietary approach is based on creating an energy deficit diet to produce weight loss while also being attentive to the quality of the calories consumed. Foods are categorized into the colors of a traffic light signal based on their nutritional and caloric content, such that youth are encouraged to eat more of green and yellow foods, and less of red foods. Participants will log their daily food intake and self-monitor dietary and physical activity behaviors, incorporating behavior substitution and habit formation. Participants will also have 15 minute weekly individualized coaching sessions.; In addition to Kurbo, participants will be asked to engage in daily cognitive training using the PolyRules! app for three months. They will be instructed to start with 20-min of daily cognitive training and to progressively increase their training time to 30-min.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
End-range Maitland Mobilization on Glenohumeral Internal Rotation Deficit and Proprioception
Condition: Sports Physical Therapy
Study type: Interventional

Summary: 
      Glenohumeral internal rotation deficit (GIRD) is one of the main reasons for glenohumeral
      pain in athletes with over-head activity. As GIRD increases, the ratio between internal and
      external rotation changes resulting in decreased joint stability.

      Joint mobilization is a possible option for the decrease of GIRD and contribution to
      improvement of proprioception in addition to physical therapy. The aim of this trial is to
      investigate the effect of end-range Maitland mobilization in addition to physical therapy on
      GIRD, other joint movements and proprioception.
    

Detailed description: 
      Glenohumeral internal rotation deficit (GIRD) is one of the main reasons for glenohumeral
      pain in athletes with over-head activity. As GIRD increases, the ratio between internal and
      external rotation changes resulting in decreased joint stability. The occurence of GIRD and
      decreased joint proprioception may lead to different shoulder pathologies (e.g. Impingement
      syndrome).

      Joint mobilization is a possible option for the decrease of GIRD and contribution to
      improvement of proprioception in addition to physical therapy. Several joint mobilization
      techniques exists, which can be applied for stretching of periarticular tissues. Maitland
      mobilization is a well applied mobilization type. The effectiveness of both end-range and not
      end-range Maitland mobilization in lengthening of periarticular tissues and improvement of
      joint proprioception has been previously confirmed amongst several diseases. However, the
      effect of end-range Maitland mobilization on decrease of GIRD and proprioception in addition
      to physical therapy has not been investigated in volleyball players so far.

      The aim of this trial is to investigate the effect of end-range Maitland mobilization in
      addition to physical therapy on GIRD, other joint movements and proprioception.
    

Intervention name(s): End-range Maitland mobilization + proprioception training; Non end-range Maitland mobilization + proprioception training; Sham manual therapy technique + proprioception training
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): End-range Maitland mobilization performed in end position of internal rotation of the shoulder accompanied with 8--week long proprioception training; Non end-range Maitland mobilization performed in loose position of the shoulder accompanied with 8--week long proprioception training; Placebo performed in loose position of the shoulder accompanied with 8--week long proprioception training
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Musculoskeletal Manipulations; Range Of Motion, Articular; Proprioception; Volleyball
Treatment of Social Phobia and Panic Disorder in Adults
Condition: Social Phobia; Panic Disorder
MeSH terms: Phobic Disorders; Panic Disorder; Phobia, Social
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to compare a stepped care model for the treatment of social
      phobia and panic disorder with standard psychological treatment. The stepped care model
      comprises three steps: short psycho-education, a 10 weeks Internet-based self-help program,
      12 weeks individual cognitive-behavioural therapy. Patients are assessed at each step and
      taken out of the study if they show significant clinical improvement and follow for 12
      months. Patients are randomized to either the stepped care model or standard psychological
      treatment, i.e. individual cognitive-behavioural therapy. All treatment components are
      manualized.
    


Intervention name(s): individual cognitive-behavioural therapy; stepped care model
Intervention type(s): Behavioral; Behavioral
Intervention description(s): 1 session per week for 12 weeks; three steps: short psycho-education, a 10 weeks Internet-based self-help program, 12 weeks individual cognitive-behavioural therapy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Cognitive therapy; Stepped care; Self-help; Internet; Anxiety
Endoscopic Sleeve Gastroplasty
Condition: Morbid Obesity
MeSH terms: Obesity, Morbid
Study type: Observational

Summary: 
      The endoscopic sleeve gastroplasty allows stomach size reduction through an endoluminal
      suture approach without any incision. It could reduce the complications associated with
      current surgical techniques while obtaining the target gastric restriction, weight loss,
      comorbidities and quality of life improvement.

      The primary objective of this study is to assess weight loss after endoscopic sleeve
      gastroplasty in patients with morbid obesity.
    

Detailed description: 
      Gastric restriction is one of the fundamental principles of gastric bypass and gastric
      banding. Nowadays, practitioners have the possibility to reduce stomach size by merging
      tissues through an endoscopic endoluminal suture approach without any incision. This could
      reduce the complications associated with current surgical techniques while obtaining the
      target gastric restriction, weight loss, comorbidities and quality of life improvement.

      The primary objective of this study is to assess weight loss after endoscopic sleeve
      gastroplasty in patients with morbid obesity according to the technique described in the
      literature: reduction of the gastric pouch into a sleeve structure by modification of the
      stomach greater curvature thanks to a plication.
    

Intervention name(s): Endoscopic sleeve gastroplasty
Intervention type(s): Procedure
Intervention description(s): Endoscopic sleeve gastroplasty is performed using a CE marked endoscopic suture device (Overstitch, Apollo Endosurgery, Austin, Tx. USA). Continuous stitches are placed to create a sleeve-shaped gastric path of 2 cm diameter to reduce stomach volume from the proximal antrum to the oeso-gastric junction.
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients over 18 years old requiring a treatment for morbid obesity.
      
Keywords: Endoscopic sleeve gastroplasty; Excess weight loss; Quality of life
A Study of a Hypertensive Population Under Treatment With Micardis® and Micardis Plus® to Control the Early Morning BP Rise (SURGE II)
Condition: Hypertension
MeSH terms: Hypertension
Study type: Observational

Summary: 
      The primary objective was to evaluate, through the use of Home blood pressure monitoring
      (HBPM), the degree of BP control in the early morning hours after 8 weeks of treatment in
      patients with essential hypertension under treatment with Micardis®, Telmisartan or Micardis
      Plus®, Telmisartan hydrochlorothiazide.

      The co-primary endpoints were the degree of BP control, and change from baseline until study
      end in mean systolic blood pressure (mSBP) and mean diastolic blood pressure (mDBP) HBPM in
      the early morning hours after 8 weeks of treatment with Micardis®, Telmisartan or Micardis
      Plus®, Telmisartan hydrochlorothiazide.

      Secondary endpoints were office BP control rates, office BP response rates, and reduction in
      mSBP and mDBP Office blood pressure measurement (OBPM) from baseline to final visit,
      discontinuations and tolerability
    


Intervention name(s): Telmisartan; Telmisartan hydrochlorothiazide
Intervention type(s): Drug; Drug
Other intervention name(s): Micardis®; Micardis Plus®
Intervention MeSH terms: Hydrochlorothiazide; Telmisartan; Telmisartan, hydrochlorothiazide drug combination
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Hypertensive population under real life clinical practice in an ambulatory setting
Single or Triple Uterine Tourniquet at Myomectomy
Condition: Uterine Myoma
MeSH terms: Leiomyoma; Myofibroma
Study type: Interventional

Summary: 
      The aim of study is to compare triple tourniquet vs. single tourniquet to reduce blood loss
      at open myomectomy.
    


Intervention name(s): Single tourniquet; Triple tourniquet
Intervention type(s): Procedure; Procedure
Intervention description(s): Single tourniquet is tourniquet applied uterine isthmus to occlude the uterine arteries. For this purpose, a small opening is made in the avascular place of the broad ligament on either side of the uterine isthmus superior to the uterine vessels. A pediatric Foley catheter is threaded through the two holes and tied tightly anteriorly around the cervix at the level of the internal os.; Triple tourniquet consist of two tourniquet applied both infundibulopelvic ligaments and one uterine isthmus to occlude the left and right ovarian vessels and to occlude the uterine arteries. For this purpose, a small opening is made in the avascular place of the broad ligament on either side of the uterine isthmus superior to the uterine vessels. A pediatric Foley catheter is threaded through the two holes and tied tightly anteriorly around the cervix at the level of the internal os.
Through the same openings in the broad ligament each side a Foley catheter looped around the infundibulopelvic ligament lateral to the fallopian tube and ovary.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Leiomyoma of uterus; Hemostasis, Surgical; Prevention of Surgical Blood Loss; mechanical uterine tourniquet
Advanced Gravitational Physiology the Lung Under High-G Acceleration
Condition: Respiratory Physiology
Study type: Interventional

Summary: 
      This is a study of advanced lung physiology in altered gravitational conditions, consisting
      of respiratory measurements in healthy volunteers during high G acceleration on a long-arm
      human centrifuge.
    

Detailed description: 
      The lung is highly gravity-dependent - it has little actual tissue mass and deforms under its
      own weight. This is relevant to astronauts in space, but is actually much more broadly
      important to life on Earth. Every time we change our posture - for example from lying to
      standing - the direction in which gravity acts across the lung changes. These postural
      effects can become clinically important in critically ill patients. Currently there is debate
      in the scientific world about how gravity actually influences lung function, and how it
      interacts with other factors such as the anatomical structure of the airways and blood
      vessels of the lung. New technology developed by researchers at the University of Oxford now
      has the potential to help answer some of these questions. This device uses a technique called
      laser absorption spectroscopy to make measurements of breathing gases that are much more
      accurate than previous techniques - it is able to count the number of oxygen, carbon dioxide
      and water vapour molecules in and out while a person breathes. A non-invasive 15-minute
      breathing test with this technology provides information on the distributions of airflow and
      blood flow in the lungs, and it has been deployed successfully in the operating theatre and
      in intensive care units. This study aims to make comprehensive measurements of lung
      physiology under altered gravitational conditions and develop the technology and measurement
      techniques for possible future use in microgravity. This will include measurements of oxygen
      and carbon dioxide from the laser gas analyser (and measures of lung inhomogeneity obtained
      from these), lung mechanics and breathing drive.
    

Intervention name(s): High G acceleration on a long-arm human centrifuge
Intervention type(s): Other
Intervention description(s): Gx (chest-to-back) and Gz (head-to-toe)
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: respiratory; physiology; gravity
Flexibility Deficit in Chronic Ankle Instability
Condition: Chronic Ankle Instability
Study type: Observational

Summary: 
      chronic ankle instability could be associated with some proximal deficits as in hip and knee
      regions. these deficits include alternations in motor neurons pools excitability, muscle
      strength, kinematics and kinetics. this study add muscle inflexibility to the preciouse
      literature.
    

Detailed description: 
      Background: influence of a localized injury in a distal joint on the function of proximal
      muscles is an important consideration in assessment and treatment of musculoskeletal
      injuries. Up to the investigator's knowledge, there is no study assess flexibility changes in
      CAI. Objectives: The objective of this study is to investigate Hamstring flexibility in CAI.
      Material and methods: The study conducted on 42 subjects with unilateral CAI and controls had
      measure of hamstring flexibility using digital inclinometer during passive knee extension
      test .Results: Revealed statistical and clinical significant difference between non-injured
      control group and CAI group with decreased hamstring flexibility in the later. Conclusion:
      CAI subjects have proximal muscular affection include hamstring tightness which may alter
      sacroiliac joint stability and subsequently back pain.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Outpatients clinic faculty of physical therapy Cairo university
      
Biospecimen description: 
      21 patients with CAI and 21 participants without ankle sprain injury
    
Keywords: chronic ankle instability; Hamstring; flexibility
Effect of Eradication of Helicobacter Pylori on the Dyspeptic Symptoms
Condition: Functional Dyspepsia; Helicobacter Pylori Infection
MeSH terms: Dyspepsia
Study type: Interventional

Summary: 
      Helicobacter pylori eradication and its impact on symptoms in patients with non-ulcer
      dyspepsia remain controversial . Many studies have examined the effect of H. pylori
      eradication on dyspeptic symptoms, but the results have been conflicting and inconclusive,
      with as many studies yielding positive as negative results. Some studies have shown a
      significant (although weak) symptomatic improvement after H. pylori eradication, and while
      other yielding negative results. A recent Cochrane review has comprehensively demonstrated
      that H.pylori eradication therapy has a small but statistically significant effect in
      H.pylori positive non-ulcer dyspepsia. An economic model suggests this modest benefit may
      still be cost effective . However it is difficult to reconcile these results in areas with
      very high prevalence of H. pylori infection such as Pakistan since no such studies have been
      conducted in developing countries.

      The investigators hypothesize that eradication of Helicobacter pylori (H. pylori) leads to a
      sustained improvement in symptoms of patients diagnosed with H. pylori associated functional
      (non-ulcer) dyspepsia.
    


Intervention name(s): Omeprazole + Clarithromycin + Amoxycillin; Omeprazole + placebo antibiotics
Intervention type(s): Drug; Drug
Intervention description(s): Omeprazole 20mg BID for 1 week along with Clarithromycin 500mg BD and Amoxycillin 1g BD for 1 week; omeprazole 20 mg bid for 1 week along with placebo antibiotics for 1 week
Intervention MeSH terms: Anti-Bacterial Agents; Amoxicillin; Clarithromycin; Omeprazole
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary purpose: Treatment
Keywords: Functional Dyspepsia; Helicobacter Pylori eradication; Quality of Life; Dyspeptic Symptoms
Comparison of Synthetic Bone Substitute and a Bovine-derived Xenograft in Horizontal Bone Augmentation
Condition: Jaw, Edentulous; Jaw, Edentulous, Partially
MeSH terms: Jaw, Edentulous; Jaw, Edentulous, Partially; Mouth, Edentulous
Study type: Interventional

Summary: 
      The objective of the study is to test the efficacy on bone formation of Straumann Bone
      Ceramic as a grafting material applied in buccal bone dehiscences on simultaneously placed
      oral implants.
    

Detailed description: 
      This is a randomized, controlled, split mouth, prospective, single centre study. The total
      study duration for each patient should be 76 weeks +/-18 months.

      In total 8 visits per patient are scheduled in this study.

      The study devices Straumann Bone Ceramic and Bio-Oss are CE-marked, and approved by the FDA.
      The products are used within the indication.

      One center in Beligum will participate.
    

Intervention name(s): Straumann BoneCeramic; Bio-Oss
Intervention type(s): Device; Device
Intervention description(s): Bone augmentation procedure performed with Bone Ceramic; Bone Augmentation procedure performed with Bio Oss
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment