bioihbjkbjnl/mcl2 huggingface dataset:
Mobilization Versus Manipulation for the Treatment of Cervicogenic Headaches
Condition: Cervicogenic Headache
MeSH terms: Post-Traumatic Headache; Headache
Study type: Interventional

Summary: 
      There is currently a gap within the literature as to the effects of a thrust versus
      non-thrust mobilizations techniques specifically to the upper cervical spine C0-C3 along with
      home exercise program to help reduce frequency and intensity of cervicogenic headaches.
      Therefore, the purpose of this study is to examine the effectiveness of in treating headaches
      using non-thrust or thrust mobilizations in addition to postural corrective exercises on
      patient outcomes measures.
    

Detailed description: 
      Cervicogenic headaches are classified as secondary headaches and typically rise from a
      musculoskeletal, cervical spine, disc, or soft tissue elements and are accompanied by neck
      pain. Dominant features of cervicogenic headache include unilateral head pain, external
      pressure over the ipsilateral upper neck, limited cervical range of motion, and trigger
      attacks by various neck motions. Cervicogenic headaches typically originate from the
      atlanto-occipital and upper 3 segments of the cervical spine and can radiate to the head or
      face region. Physical therapist have for some time been treating cervicogenic headaches with
      a variety of different treatment techniques ranging from conservative therapy, passive and
      active range of motion, stretching for cervical, strengthening exercises for the upper
      extremity, and manual therapy. However, little is known about the effects of thrust and
      non-thrust manipulative physical therapy treatments along with exercises to help reduce
      cervicogenic headaches. The purpose of this study is to assess the effectiveness of physical
      therapy in treating headaches using non-thrust to the upper 3 segments of the cervical spine
      or thrust mobilizations to the upper 3 segments, plus the addition of postural corrective
      exercises in treating cervicogenic headaches.
    

Intervention name(s): Thrust Mobilization; Non-Thrust Mobilizations
Intervention type(s): Other; Other
Intervention description(s): Once therapist has assessed subject and has found the patients most comparable sign they will be performing a high velocity thrust at the end of the patients available range, as described by Maitland's Approach. The thrust will be performed only once. The therapist will perform either a localized cervical rotation thrust which primary movement is rotation or a longitudinal cephalad C1 and C2 thrust, both targeting the upper cervical spine; Therapists will perform unilateral posterior to anterior mobilization (UPA) or central posterior to anterior (CPA) mobilizations grades I-IV as described above by Maitland concepts at levels C0-C3 which reproduce the patient's most comparable sign. Therapists will be instructed to perform 3x 30 second bouts of mobilizations at that level.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Treatment of Lateral Elbow Tendinopathy
Condition: Epicondylitis, Lateral Humeral
MeSH terms: Tendinopathy; Elbow Tendinopathy; Tennis Elbow
Study type: Interventional

Summary: 
      This study investigates the treatment effect on lateral elbow tendinopathy of strength
      training in combination with cortico-steroid injection, dry-needling or placebo in a
      double-blinded randomized controlled trial.
    

Detailed description: 
      The prevalence of lateral elbow tendinopathy is prevalence of 1-3%, with a peak incidence
      between 35-50 years of age (Green et al., 2002). The main symptoms are pain over the lateral
      humeral epicondyle upon palpation and pain full resisted dorsiflexion of the wrist.
      Ultrasonographic changes include hyper-/hypo-echoic areas and increased doppler signal in the
      most proximal part of the common extensor tendon. The condition is often self-limiting,
      however full recovery often takes months to years and recurrence is common. Several different
      treatment modalities are used in order to increase tendon healing and decrease time to
      recovery. Deep transverse friction massage showed no significant effect on pain, grip
      strength or function relative to other physiotherapy modalities (Brosseau et al., 2002).
      Anti-inflammatory treatment with NSAID's or corticosteroids is typically effective in the
      short term, however on a longer term there is a poorer outcome than with other treatment
      strategies including exercise (Coombes et al., 2010). Surgery does not seem to have any
      beneficial effect (Buchbinder et al., 2011), and there are no conclusive data regarding the
      use of orthotic devises for the treatment of lateral elbow tendinopathy (Struijs et al.,
      2002). Eccentric exercise of the extensor muscles has been shown to reduced pain, increase
      muscle strength, and decrease tendon thickness and time to return to sport (Croisier et al.,
      2007).

      Loading of human tendon leads to increased tendon collagen synthesis, and interestingly,
      tendon tissue sampling (biopsies), which causes a minor trauma to the tendon has been shown
      to increase the level of growth factors locally and stimulate tendon collagen synthesis
      (Magnusson et al., 2010).

      It is hypothesized that both minimal tissue damage and anti-inflammatory treatment could
      increase tendon healing and decrease time to recovery, when combined with mechanical loading.
    

Intervention name(s): Strength Training; Placebo; Cortico-Steroid Injection. Depomedrol 40mg/1ml.; Dry Needling
Intervention type(s): Other; Procedure; Drug; Procedure
Intervention MeSH terms: Methylprednisolone Acetate; Methylprednisolone; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
ST36 Acupoint Injection With Anisodamine for Postoperative Nausea and Vomiting
Condition: Postoperative Nausea and Vomiting
MeSH terms: Nausea; Vomiting; Postoperative Nausea and Vomiting
Study type: Interventional

Summary: 
      Postoperative nausea and vomiting (PONV) is particularly distressing although it is not a
      fatal postoperative complication. Numbers of studies have been focused on identifying risk
      factors and therapies of PONV. Unfortunately, there' no consistent comments for PONV
      prevention in women after laparoscopic sleeve gastrectomy. Notably, Zusanli (ST36) acupoint
      and anisodamine have been evidenced to treat various gastrointestinal conditions. The primary
      outcome of this study was to evaluate the impact of anisodamine injection in ST36 on PONV in
      women following bariatric surgery.
    

Detailed description: 
      Acupuncture has been used as a medical technique in China for at least 2,000 years. More
      recently, it's also been extensively used in managing headache, chronic back pain, and PONV
      in USA. ST36 acupuncture is reported to be an effective preventive treatment for
      postoperative nausea and vomiting (PONV). However, It is not clear if it could efficiently
      prevent PONV in female patient who has underwent bariatric surgery. At the onset of this
      investigation, we have already identified several methodologic issues, such as the timing of
      the acupuncture intervention, sample size, perioperative anesthetic techniques, and
      appropriate control groups. The primary outcome of this study was the total incidence of PONV
      during the hospital and after the discharge. Participants were randomly assigned into
      different groups according to the with a computer-generated randomization sequence
      (http://www.randomization.com). Patients, surgeons, anesthesiologists, nursing staff, and the
      research assistant, were all blinded to the group assignment.
    

Intervention name(s): ST36 acupuncture
Intervention type(s): Procedure
Intervention description(s): ST36 is located on the lateral surface of leg, 3 cun distal to the lower border of the patella, 1 finger-breadth lateral to the anterior crest of the tibia, between the tibialis anterior muscle and the tendon of the extensor digitorum longus. (The breadth of patient's middle finger was the proportional unit of measure "the cun", defined as the distance between the two medial ends of the creases of the interphalangeal joints when the patient's middle finger is flexed).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: postoperative nausea and vomiting; bariatric surgery; Zusanli (ST36); anisodamine
Effects of Sensomotoric Insoles on Postural Control in Elderly People
Condition: Sensorimotor Gait Disorder
MeSH terms: Gait Disorders, Neurologic
Study type: Interventional

Summary: 
      People with weak balance ability or subjective feeling of dizziness and unsure gait are
      separated into 3 training-groups. One Group is getting no insoles, the second group is
      getting modern sensomotoric insoles, and the third group is getting normal standard insoles.
      All are passing a 6 week proprioceptive training.

      Main outcome measurements are posturography at baseline, 3 weeks and 6 weeks. Secondary
      measurements are ABC-Scale, Tinetti Gait and balance test and functional reach test at
      baseline and after 6 weeks.
    

Detailed description: 
      People with weak balance ability or subjective feeling of dizziness and unsure gait are
      separated into 3 training-groups. Exclusion criteria are structural neuropathic cause for
      dizziness, severe ocular deficience, cochlear causes for dizziness.

      The 3 Groups differ in following criteria:

      Group 1: Gets basic insoles after 3-D-Scan of the foot Group 2: Gets sensomotoric insoles
      (Jahrling) after 3-D-Scan of the foot. Group 3: Control-Group = no insoles

      Alle groups are doing a 6 weeks proprioceptive training 2 times a week for 45min.
      Balance-Ability is measured by a posturographic plate prior to the training, after 3 weeks
      training and after 6 weeks of training. ABC-Score, Tinetti Gait and Balance test and
      functional reach test are secondary outcome measurements and are evaluated prior the training
      and after 6 weeks of training.
    

Intervention name(s): sensomotoric insoles; normal standard insoles; No insoles
Intervention type(s): Device; Device; Other
Intervention description(s): sensomotoric insoles were published by Jahrling (2007) and have a certain shape that could improve balance abilities. The toes 2-4 are higher that toe 1, so that the tendons of the toe-flectors are pre-stressed.; Normal standard insole like you will get them by receipe from an orthotic shop; control group with no insoles in the shoes
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Prospective randomized controlled trial
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: sensomotoric insoles; postural control; proprioceptive insoles; insoles
PET Trial to Evaluate Target Occupancy of CVL-231 on Brain Receptors Following Oral Dosing
Condition: Schizophrenia
MeSH terms: Schizophrenia
Study type: Interventional
Phase: Phase 1

Summary: 
      PET Trial to Evaluate Target Occupancy of CVL-231 at Muscarinic Receptors Type 4 in Brain
      Following Oral Dosing
    

Detailed description: 
      CVL-231 is a muscarinic acetylcholine receptor (mAChR) activator that selectively binds to
      the M4 muscarinic receptor subtype (M4 mAChR). CVL-231 is being developed for treatment of
      psychosis in schizophrenia. The aim of this trial is to characterize the relationship between
      the M4 receptor occupancy in different regions of the brain following a single oral doses of
      CVL-231 in healthy adult subjects by positron emission tomography (PET) using the radioligand
      [11C]MK-6884.
    

Intervention name(s): CVL-231; CVL-231; CVL-231
Intervention type(s): Drug; Drug; Drug
Intervention description(s): Cohort 1: 30mg dose of CVL-231; Cohort 2: CVL-231 dose to be decided based on results of Cohort 1 or trial may be concluded; Cohort 3: CVL-231 dose to be decided based on results of Cohorts 1 and/or 2
Other intervention name(s): PF-06852231; PF-06852231; PF-06852231
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Schizophrenia; PET; Healthy Volunteer
Protection of Rectum From High Radiation Doses
Condition: Prostate Cancer
MeSH terms: Prostatic Neoplasms
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate the usefulness of diluted DuraSeal product as a
      spacer between prostate and rectum in prostate cancer low dose brachytherapy.
    

Detailed description: 
      Radiation therapy for prostate cancer leads to inappropriate radiation dose to the rectum
      wall leading rectum adverse effects in long term for some patients. A resorbable spaces
      between prostate and rectum could decrease the incidence of these side effect. In this trial,
      men with prostate cancer with intention to curative treatment by low dose brachytherapy will
      be recruited. Diluted DuraSeal will be applied between rectum and prostate at the end of the
      brachytherapy seed implantation procedure. After the implantation of the brachytherapy seeds,
      a needle is placed between rectum and prostate through perineal skin under transrectal
      ultrasound guidance. The proper position of the needle is confirmed by the injection of 10-15
      ml sterile saline solution. After that, DuraSeal components are diluted in 1:1 with sterile
      saline and 6-10 ml of this diluted product will be injected using DuraSeal applicator. The
      resolution of the spacer will be followed by repeated plain computer tomography (CT) of
      pelvis performed a day before operation, a day after the operation, 4 weeks after the
      operation and 8 weeks after the operation. In addition, magnetic resonance imaging of pelvis
      performed 8 to 16 weeks after the operation. The space created between prostate and rectum
      will be documented by plain CT and magnetic resonance imaging. Rectum radiation dose will be
      calculated based on these scans. Time to DuraSeal resolution will be evaluated from the
      scans. Possible side effects will be collected by subject interviews during follow-up visits
      at 4, 8 and 12 weeks after the operation.
    

Intervention name(s): DuraSeal
Intervention type(s): Device
Intervention description(s): Single dose of DuraSeal product with DuraSeal components diluted 1:1 in sterile saline injected between rectum and prostate
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: prostate cancer; brachytherapy; spacer; side effect
Single Versus Multi-port Robotic Assisted Sacrocolpopexy for Repair of Vaginal Apex Prolapse
Condition: Pelvic Organ Prolapse
MeSH terms: Prolapse; Pelvic Organ Prolapse
Study type: Interventional

Summary: 
      A prospective randomized controlled study intended to compare the efficacy of 2 methods of
      robotic assisted sacrocolpopexy for the repair of vaginal apex prolapse:

        1. Via single-port.

        2. Via multi-port.
    

Detailed description: 
      One hundred female patients diagnosed with vaginal apex prolapse will be recruited to a
      prospective randomized controlled study intended to compare the efficacy of 2 methods of
      robotic assisted sacrocolpopexy:

        1. Via single-port.

        2. Via multi-port. The patients will be evaluated and randomized 2 weeks before the
           expected date of surgery during which eligibility will be examined.

      Patients' electronic files will be reviewed post operatively to acquire information regarding
      medical history, prolapse scores, surgical information, anesthesia information and surgical
      complications.

      Patients will have 3 week and 3 month post operative follow-up sessions to determine surgical
      success, late complications and patient satisfaction.
    

Intervention name(s): Single-port sacrocolpopexy; Multi-port sacrocolpopexy
Intervention type(s): Procedure; Procedure
Intervention description(s): Single-port sacrocolpopexy surgery for the repair of vaginal apex prolapse.; Multi-port sacrocolpopexy surgery for the repair of vaginal apex prolapse.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Comparison of Two Neuromuscular Anesthetics Reversal in Obese Patient Undergoing Bariatric Surgery
Condition: Anesthesia; Surgery
Study type: Observational

Summary: 
      The study is a prospective, single center, double arm study aiming at the comparison of 2
      commercial neuromuscular block reversal drugs: Neostigmine (Cooper S.A.) and Sugammadex
      (MSD). A faster recovery from neuromuscular block is expected for patients receiving
      Sugammadex and this protocol is of high importance for anesthesia of morbid obese patients
      during bariatric surgery.
    


Intervention name(s): Sugammadex vs. Neostigmine
Intervention type(s): Drug
Intervention description(s): Sugammadex Group (n=20) - anesthesia induced by Rocuronium 0.4mg/kg body, additional Rocuronium 0.1-0.2 mg/kg body as needed during surgery (not more than x2), muscular blockage reversal using Sugammadex 2.0 mg/kg body.
Neostigmine Group (n=20) - anesthesia induced by Rocuronium 0.4mg/kg body, additional Rocuronium 0.1-0.2 mg/kg body as needed during surgery (not more than x2), muscular blockage reversal using Neostigmine 0.05 mg/kg body and atropine 0.1 mg/kg body.
Intervention MeSH terms: Neostigmine
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Subjects for the study will be recruited from patients within the community who have sought
        treatment for morbid obesity by bariatric surgery, are qualified for the surgery and meet
        all of the eligibility criteria listed below.
      
Keywords: Morbid obesity; Bariatric Surgery; Neuromuscular block reversal
Study Evaluating The Potential Effect Of Multiple Doses Of Neratinib On The Pharmacokinetics Of A Single Dose Of Digoxin
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the potential effect of multiple doses of neratinib
      on the pharmacokinetics (how the body absorbs, distributes, metabolizes and/or excretes) of a
      single dose of digoxin.
    


Intervention name(s): Digoxin; Neratinib
Intervention type(s): Drug; Drug
Intervention description(s): HKI-272
Intervention MeSH terms: Digoxin
Allocation: Non-Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Healthy Subjects
Ultrasound Guided Versus Landmark Guided Arterial Line Placement by Emergency Medicine Interns
Condition: Vascular Access Complication
MeSH terms: Emergencies
Study type: Interventional

Summary: 
      Critically ill patients in the emergency department commonly require arterial line placement
      for continuous direct blood pressure monitoring, frequent arterial blood gas sampling, and
      frequent blood sampling. Trans-radial catheterization has been shown to reduce access site
      complications and increase patient comfort compared to trans-femoral access. Radial artery
      access on the first attempt is optimal; attempts at reentry delay care and increase the risk
      of vascular spasm, hematoma, infection, neurovascular injury, and pain. The traditional pulse
      palpation method of radial artery cannulation can be challenging, especially in patients with
      weak pulses (i.e. morbidly obese or hypotensive individuals).

      A review of literature suggests that ultrasound guided trans-radial catheterization compared
      to standard pulse palpation reduces access time and increases rate of first-entry success
      when performed by physicians trained in ultrasound. Thus, complications ascribed to reentry
      are prevented and timely care is provided.

      To the investigator's knowledge, only one other prospective study has been conducted to
      assess the utility of ultrasound guided radial artery cannulation in the emergency
      department. Due to the paucity of literature to support the use of ultrasound guided
      trans-radial catheterization in critically ill patients, the study will aim to provide
      further data on the topic. Both techniques are considered standard of care.
    

Detailed description: 
      Patients presenting to the Emergency Department 18 years old or greater, who do not belong to
      a vulnerable group, requiring arterial line placement will be included in this trial. The
      investigators will randomize each patient into LM vs US. Data collected will include number
      of attempts, success rate, and time for procedure to be completed. PGY-1 residents will
      perform the arterial line placement.
    

Intervention name(s): Arterial Line Placement
Intervention type(s): Procedure
Intervention description(s): arterial line placement
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Care Provider)
Primary purpose: Diagnostic
A Study to Evaluate the Safety, Tolerability, and Blood Levels of ACU193 in Participants With MCI or Mild AD
Condition: Alzheimer Disease
MeSH terms: Alzheimer Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      This Phase 1 study is a single ascending dose (SAD) and multiple ascending dose (MAD),
      placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics (PK), and
      pharmacodynamics (PD) of intravenous ACU193 when administered to participants diagnosed with
      Mild Cognitive Impairment (MCI) or Mild Dementia due to Alzheimer's disease (AD).
    


Intervention name(s): ACU193; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Intravenous ACU193; Intravenous Placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Study ACU-001 is a placebo-controlled study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple escalating doses of intravenous ACU193. A two-part single-ascending dose (SAD)/multiple-ascending dose (MAD) study design will be conducted in a population of individuals with early AD (MCI or mild dementia due to AD).
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Alzheimer's Diseases; Mild Cognitive Impairment; Mild dementia