bioihbjkbjnl/mcl2 huggingface dataset:
Prematurity and Parental Involvement in Child Development Care
Condition: Premature Birth
MeSH terms: Premature Birth
Study type: Observational

Summary: 
      The aims of the study is to evaluate the association between presence and parental
      participation in perinatal care and psychic development of the child at 24 months
    

Detailed description: 
      In France, as in developed countries, the premature birth rate has been rising over the past
      few years. Premature labor is a particularly stressful birth. It is recognized that the level
      of parental stress is greater at a premature birth compared to a term birth. The
      neuro-developmental consequences of premature birth are important. A possible association
      between prematurity and the onset of mental disorders such as hyperactivity, inattention,
      emotional problems, conduct disorders, autistic disorders and social difficulties has been
      shown. It has been shown that parental presence, holding and skin to skin during
      hospitalization would be beneficial for the child's motor development and psychological
      well-being by reducing the stress of the child.
    

Intervention name(s): Questionnaires to evaluate psychic development of the child
Intervention type(s): Other
Intervention description(s): Child Behaviour Checklist. This test, completed by parents and with 52 questions, is designed to screen children at high risk for emotional problems, mood disorders, anxiety, pervasive developmental problems, attention deficit and hyperactivity, antonymic reactions (oppostion, provocation) and sleep problems.
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Premature children
      
Keywords: Parental presence; parental involvement; parental stress; development care; psychic development
Plexin B2 Gene Expression and Polymorphisms in Psoriasis
Condition: Psoriasis Vulgaris
MeSH terms: Psoriasis
Study type: Interventional
Phase: Phase 1

Summary: 
      Patients will be randomly assigned (1:1:1 ) either to ; NB-UVB photo-therapy alone ,
      Acitretin therapy alone or NB-UVB photo-therapy combined with Acitretin therapy randomization
      will be done by closed envelopes . investigator will be blinded to study drug assignment ,
      while patients and data interpreter will not be masked to study drug assignment.
    

Detailed description: 
      Study Setting: Qena University Hospital, Department of Dermatology ,Venereology& Andrology.

      Study subjects: the study will include psoriasis Vulgaris patients who Come to the out
      patients dermatologic clinic and matching inclusion & exclusion criteria as follow, from
      9/2021 up to 3/2023 and then patients will be divided to each group equally as follow:

      Group 1: Patients will be treated with NB-UVB phototherapy 3 sessions weekly for 3 months
      with maximum dose of 1400 mJ/cm2.

      Group 2: Patients will be treated with Acitretin in dose of 0.5-1 mg per kg per day orally
      for 3 months Group 3: Patients will be treated with Acitretin in dose of 0.5-1 mg per kg per
      day orally plus NB-UVB phototherapy 3 sessions weekly for 3 months with maximum dose 1400
      mJ/cm2.

      Group 4: 30 healthy individuals un related , age, sex , BMI matched with volunteers.
    

Intervention name(s): Narrow band Ultraviolet B phototherapy group; Acitretin group; Acitretin plus Narrow band Ultraviolet B phototherapy group
Intervention type(s): Radiation; Drug; Combination Product
Intervention description(s): 3 sessions weekly for 3 months with maximum dose 1400 mJ/cm2.; dose of 0.5-1 mg per kg per day orally for 3 month.; Acitretin in dose of 0.5-1 mg per kg per day orally plus Narrow band Ultraviolet B phototherapy 3 sessions weekly for 3 months with maximum dose 1400 mJ/cm2.
Other intervention name(s): NB-UVB
Intervention MeSH terms: Acitretin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Cost-effectiveness of Topical Fluoride in Preventing Deciduous Dental Caries in Preschool Children
Condition: Dental Caries in Children
MeSH terms: Dental Caries
Study type: Interventional

Summary: 
      Fluoride foam and fluoride varnish are effectiveness in prevention deciduous dental caries.
      However, the relative clinical efficacy and cost-effectiveness of these two interventions are
      uncertain. This study aims to evaluate the relative clinical effectiveness and
      cost-effectiveness of fluoride foam and fluoride varnish in preventing dental caries in the
      primary teeth of preschool children with high caries risk.
    

Detailed description: 
      This 24-month randomized clinical trial aims to compare the clinical efficacy and
      cost-effectiveness of topical fluoride application of fluoride foam and fluoride varnish in
      preventing dental caries in the primary teeth of preschool children with high caries risk in
      Harbin,Heilongjiang Province,China.

      Preschool children (3-4 years) with high caries risk will be invited to participant in this
      study. An invitation letter will be sent to the parents explaining the purpose and procedures
      of this study.Parental concent will be sought.

      The children will be randomly divided into three groups: the control group-no intervention;
      the intervention group 1 - applications of 1.23% fluoride foam every 6 months; the
      intervention group 2- applications of 2.26% fluoride varnish every 6 months.

      Dental clinical examination of the children will be performed at the beginning of the
      study,12 months and 24 months later.The dental examiners will receive unified training and
      consistency test of dental caries survey.Only when the Kappa value reached 0.8 can oral
      examiners participate in the oral examination.Dental caries condition will be recorded.
      Approximately 5% of children will be re-examined to determine the reliability of the results.

      The status of any possible side/adverse effects will be recorded in the follow-up
      examinations.

      The data of the study will be analysed by SPSS Statistical Analysis Software.The differences
      among the groups will be calculated and compared. And p<0.05 will be considered statistically
      significant.
    

Intervention name(s): 1.23% fluoride foam application; 2.26% fluoride varnish application
Intervention type(s): Drug; Drug
Intervention description(s): topical application of fluoride foam every 6 months; topical application of fluoride varnish every 6 months
Other intervention name(s): fluoride foam; Duraphat (Colgate)
Intervention MeSH terms: Fluorides; Fluorides, Topical
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Prevention
Keywords: cost effectiveness; fluoride foam; fluoride varnish; dental caries; clinical trial
Antimicrobial Agent for Reducing Bacteria in Aerosols and Oral Cavity
Condition: Dental Prophylaxis and Implant Surgery
Study type: Interventional
Phase: Phase 4

Summary: 
      The primary objective of this study will be to evaluate the effect of two week pre-surgical
      rinsing with an antimicrobial mouthrinse containing 0.2% w/v Chlorhexidine digluconate on the
      total number of plaque bacteria in the mouth 3 days post implant surgery. The study will be
      conducted at Eastman Clinical Investigation Centre (ECIC), University College London (UCL)
      Eastman Dental Institute. Participants will be those who require a single and simple surgical
      implant to be placed, and will be recruited from new patient referrals within the Eastman
      Dental Hospital
    


Intervention name(s): 0.2% w/v Chlorhexidine digluconate; Sodium fluoride toothpaste (Aquafresh Mild & Minty)
Intervention type(s): Drug; Drug
Intervention description(s): Participants will brush their teeth with the reference product (toothpaste) and thoroughly rinse their mouth with water and wait 5 timed minutes before using 10 ml of the 0.2% w/v Chlorhexidine digluconate mouthwash, except when using at site, where no brushing will take place prior to using the mouthrinse.; Participants will apply a strip of toothpaste to cover the head of the toothbrush and will brush in their usual manner for two timed minutes twice daily. They will then rinse their mouth thoroughly with water after brushing
Intervention MeSH terms: Chlorhexidine; Chlorhexidine gluconate; Listerine; Fluorides; Sodium Fluoride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Primary purpose: Prevention
Omega 3 Fatty Acids on Serum Irisin and Sirtuin-1 in Type 2 Diabetic Mellitus Patients Treated With Glimepiride
Condition: Diabetic Patients
Study type: Interventional

Summary: 
      study the effect of omega 3 fatty acids on blood glucose, lipids profile, serum Irisin and
      sirtuin-1 in type 2 diabetic mellitus patients treated with glimepiride.
    

Detailed description: 
      1. Approval will be obtained from Research Ethics Committee of Faculty of Pharmacy,
           Damanhour University

        2. All Participants agreed to take part in this clinical study and provide informed
           consent.

      Methodology

        -  The study will be conducted in 70 patients who are aged 30-60 years old with type 2
           diabetes mellitus for at least 2 years. The patients will be assigned into two groups
           (Omega - 3/glimepiride, n=35; glimepiride, n=35).

        -  Serum Irisin, sirtuin-1, Hb A1C, Fasting blood sugar (FBS), Lipid profile, Fasting
           insulin, HOMA-IR and Atherogenic index of plasma (AIP) will be measured at the beginning
           and after 12 weeks of intervention.

        -  Anthro-pometric parameters including Weight and height to calculate body mass index will
           be measured at the beginning and after intervention.

        -  past medical history and medication history will be documented.

        -  Each subject in the test group will receive a total dose of 1000 mg of omega-3 fatty
           acids per day in the form of three capsules along with a glimepiride tablet to be taken
           once daily, while each subject in the other group will receive glimepiride tablet to be
           taken once daily for 12 weeks.

        -  Venous blood samples will be obtained from patients at the beginning and after 12 weeks
           of intervention.

        -  A commercially available enzyme-linked immuno-sorbent assay kits will be used for the
           measurement of Irisin and sirtuin-1.

        -  The patients will be advised not to change their usual diet, drug regimen and physical
           activity levels throughout the study.
    

Intervention name(s): Omega 3 fatty acids 1000 mg per day + glimepiride 2 mg or 3 mg oral; Glimepiride
Intervention type(s): Dietary Supplement; Drug
Intervention description(s): Omega 3 fatty acids 1000 mg per day oral; glimepiride 2 mg or 3 mg per day oral
Other intervention name(s): Omega three; Amaryl
Intervention MeSH terms: Glimepiride
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The patients will be divided into two groups: group 1 treated with (Omega - 3 and glimepiride, n=35). group 2 treated with glimepiride alone, n=35).
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: Irisin; sirtuin-1; Omega 3 fatty acids
Validation and Evaluation of a Portable Body Scanner for Determination of Obesity
Condition: Obesity
MeSH terms: Obesity
Study type: Observational

Summary: 
      The objective of this study is to validate a portable 3D human body measurement system which
      will improve approaches in obesity assessment.
    

Detailed description: 
      Obesity has become an epidemic in the United States. A new technique of three-dimensional (3
      D) photonic scanning will be used to create and validate a portable instrument that rapidly
      assesses obesity in clinical and field settings. This new portable body scanner will be a
      safe and easy method to help determine the incidence and type of obesity.
    

Sampling method: Non-Probability Sample
Study population: 
        Subject will be 18-60 years old, BMI 18.50 to 39.99 kg/m3, and free of known diseases, who
        are Hispanic and Not Hispanic or Latino Whites.
      
Keywords: Body Scanning; Body Fat; Body Volume; Obesity; No Conditions
Effectiveness of Kinesiotaping in Primary Dysmenorrhea
Condition: Primary Dysmenorrhea
MeSH terms: Dysmenorrhea
Study type: Interventional

Summary: 
      Determine the effectiveness of kinesiotaping on pain in primary dysmenorrhea.
    

Detailed description: 
      Primary dysmenorrhea is defined as cramping pain in the lower abdomen occurring just before
      or during menstruation, in the absence of other diseases.

      Dysmenorrhea is estimated to occur in 45% to 90% of women of reproductive age. It is a common
      cause of absenteeism and reduced quality of life in women.

      Treatment for dysmenorrhoea aims to relieve pain or symptoms either by affecting the
      physiological mechanisms behind menstrual pain (such as prostaglandin production) or by
      relieving symptoms.

      First line treatment for dysmenorrhoea is oral contraceptives, non-steroidal
      anti-inflammatory drugs, paracetamol or aspirin. However these present side effects and some
      women have contraindications to these treatments. Consequently, it´s necessary to study
      alternative treatments to drug treatments. Alternative treatments like heat, massage therapy,
      acupuncture also are used.

      The Kinesiotaping uses an adhesive elastic cotton tape color invented by Dr. Kase in the
      1970s. It is water resistant and retains its properties up to 5 days.

      It has the characteristic to cause elevation of the epidermis and thereby reduce the pressure
      on the mechanoreceptors below the dermis. This would have the effect of reducing nociceptive
      stimuli.
    

Intervention name(s): kinesiotape; Usual care
Intervention type(s): Device; Other
Intervention description(s): For the Kinesio taping group, a piece of Kinesio tape 5 cm in width and 7-8 cm in length will be applied right from below the navel and will reach to where the pubic hair begins, and another piece of tape 10 cm in length will be applied to make a cross shape with the first piece. A tape of 20cm in length will be placed horizontally to the lower back.; Participants will note the usual self-care used to relief pain (NSAIDs, heat, massage therapy.....).
Other intervention name(s): self-care
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Each woman will be assigned to a sequence of treatments, including two treatments (kinesiotape and usual dysmenorrhea treatment). The sample will be randomized in two different sequences of treatments (kinesiotape/usual treatment or usual treatment/kinesiotape)
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: Primary Dysmenorrhea; Kinesio Taping
ReNu™ Injection to Treat Hip Osteoarthritis Study
Condition: Osteoarthritis, Hip
MeSH terms: Osteoarthritis; Osteoarthritis, Hip
Study type: Interventional

Summary: 
      A pilot study to evaluate changes in hip function and pain in patients with osteoarthritis
      receiving the ReNu™ Hip Injection.
    

Detailed description: 
      This is a prospective, non-randomized pilot study evaluating the efficacy of ReNu™ hip
      injection on patients with moderate osteoarthritis. The effects will be measured primarily
      through patient-reported outcomes questionnaires after a single injection. Patients will be
      followed up to 12 months to evaluate improvements using common pain and function subscales.
    

Intervention name(s): ReNu™ Injection
Intervention type(s): Other
Intervention description(s): Injection into the hip for the treatment of Osteoarthritis.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
3D Radiographic Evaluation of a Novel Implant Site Development Technique
Condition: Tooth Extraction Status Nos; Edentulous Alveolar Ridge
MeSH terms: Mouth, Edentulous
Study type: Interventional
Phase: Phase 4

Summary: 
      The present retrospective study aims at assessing the clinical effects of a novel implant
      site development (Extraction site development - XSD) technique after tooth extraction
      compared with extraction alone in patients requiring dental implant placement following
      healing of extraction sockets.
    

Detailed description: 
      In advanced (Extraction Defect Sounding Class 3-4) alveolar defects, a minimally invasive
      tunnelised socket preservation technique utilising long term resorbable membranes and
      connective tissue grafting was used for extraction site development (XSD). The novel
      technique was evaluated in a retrospective comparative case series study including a total of
      54 extraction sites. In the test group, out of 33 single rooted teeth, 29 in the maxilla and
      4 in the mandible were removed, extractions sites were treated by the XSD method. Out of 33
      teeth, 27 were incisors, 2 canines and 4 premolars. In the control group, out of 21 single
      rooted teeth, 11 in the maxilla and 10 in the mandible were extracted and left for
      spontaneous healing. Out of 21 teeth, 13 were incisors, 2 canines and 6 premolars. CBCT scans
      were taken prior to tooth extraction and 6-9 months later in both groups. Radiographic
      evaluation was carried out using the I-CAT Vision (Imaging Sciences International, LLC;
      Hatfield, USA) and ImageJ (National Institutes of Health) softwares. Following manual
      alignment of CBCTs vertical and horizontal linear measurements as well as planimetric
      measurements of cross-section areas were performed in pre- and postoperative data sets at the
      extraction sites.
    

Intervention name(s): Extraction site development
Intervention type(s): Procedure
Intervention description(s): In the test group, extraction sockets presenting EDS Type 3-4 buccal bony dehiscences were treated by a novel minimally invasive tunnelised modified GBR approach (XSD).
Other intervention name(s): XSD
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: socket preservation, implant site development
Probiotics and Hemodynamic Changes in Cirrhosis
Condition: Cirrhosis
MeSH terms: Liver Cirrhosis; Fibrosis
Study type: Interventional

Summary: 
      This is a single-center blinded randomized interventional placebo-controlled study of the
      effect of probiotics on hemodynamic parameters and liver function in cirrhosis.
    

Detailed description: 
      Forty patients with Child-Pugh class B and C cirrhosis will be randomized in a 1.5:1 ratio to
      test and control arms. Patients in the test arm will receive probiotic Saccharomyces
      boulardii (A07FA02 - Saccharomyces (Enterol) Biocodex Ltd, France, registration number
      LP-000622 from 21.09.2011) for 3 months, patients in the control arm will receive placebo for
      3 months. All patients also will receive standard treatment: spironolactone 100 mg/day in
      ascites and carvedilol 12.5 mg/day in esophageal varices. The patients will be blinded. At
      inclusion and after 3 months after starting of probiotic/placebo treatment, systemic
      hemodynamics parameters (cardiac output and systemic vascular resistance), liver function
      (serum albumin and total bilirubin level, international normalized ratio, presence and degree
      of ascites or hepatic encephalopathy), the gut microbiome, biomarkers of bacterial
      translocation (presepsin, lipopolysaccharide), intestinal permeability (claudin 3), systemic
      inflammation (tumor necrosis factor alpha ) and endothelial dysfunction (nitrites,
      endothelin) will be assessed. After the end of the study, an interim analysis of the effect
      of the probiotic on aforementioned systemic hemodynamics and liver function indicators will
      be carried out. If there is a positive effect, a full analysis of all the aforementioned
      factors contributing to its development will be performed.
    

Intervention name(s): Saccharomyces Boulardii Probiotic Supplement; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Probiotic yeast; Placebo
Other intervention name(s): Probiotics; Enterol; No other name
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: gut-liver axis; microbiota; microbiome; liver; cirrhosis; hemodynamics
Management of Children With Moderate Acute Malnutrition in Mali
Condition: Moderate Acute Malnutrition (MAM)
MeSH terms: Malnutrition
Study type: Interventional

Summary: 
      The objectives of the study are to assess the impact of different dietary strategies for the
      management of children with MAM on: the children's continued participation in the nutritional
      rehabilitation program and their physical growth, recovery from MAM, and change in
      micronutrient status and body composition. The specific dietary regimens that will be
      compared are: 1) a ready-to-use, lipid-based supplementary food (Plumpy'Sup, Nutriset, Inc.),
      providing ~500 kcal/d for 12 weeks; 2) specially formulated CSB for malnourished children,
      providing ~ 500 kcal/d for 12 weeks; 3) Misola, a locally produced, micronutrient-fortified,
      cereal-legume blend, providing ~500 kcal/d for 12 weeks; or 4) packaged, home available foods
      (millet and cowpea flour, sugar, vegetable oil) and a multiple micronutrient powder ("Mix
      Me") for 12 weeks, as is currently recommended by the national CMAM protocol when special
      foods are not available.
    


Intervention name(s): Plumpy'Sup; Local food supplement; Misola; SCSB
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): Lipid-based (vegetable oil, peanut paste, soy protein-containing) fortified nutrient supplement to provide 500 kcal/d; Local foods (millet flour, cowpea flour, sugar, vegetable oil) and a multiple micronutrient powder ("Mix Me") are provide, according to the national Mali CMAM protocol when special processed foods are not available.; Locally produced, millet-soy-peanut-based fortified complementary food (Misola); Processed, fortified, corn-soy-milk-based food blend (SCSB for malnourished children, to be supplied by the World Food Program) to provide an additional 500 kcal/day
Other intervention name(s): Plumpy'Sup, Supplementary Plumpy, Nutriset, France; Misola, Mali; World Food Program
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment