bioihbjkbjnl/mcl2 huggingface dataset:
Mobilition With Movement and Soft Tissue Mobiiztion in Tennis Elbow
Condition: Tennis Elbow
MeSH terms: Tennis Elbow
Study type: Interventional

Summary: 
      Lateral epicondylitis or tennis elbow is one of the most common lesions of the arm. This
      injury is a major challenge, as it is difficult to treat, prone to recurrence and may last
      for several weeks or months, with an average duration of a typical episode which has been
      reported to be between six months to two years. This is an RCT study. Subjects who fulfilled
      inclusion criteria will be taken for the study. Before conducting the actual method for
      subjects, lateral epicondylitis evaluation is done. First day before treatment, pain
      evaluation were done by using Numeric Pain Rating Scale. Muscle power was assessed by MMT
      (Manual Muscle Testing) and the function level are tested by Patient-Related Tennis Elbow
      Evaluation (PRTEE) questionnaire and asked to mark the results. Subjects will be divided into
      2 groups randomly by lottery method. Each group consists of 15 patients. Group A will be
      given MWM; Group B will be given soft tissue mobilization. Both groups will be given with the
      above said methods for alternative days in a week as per 3 sessions per week for 4 weeks. At
      the end of program subjects will be reassessed by recording muscle strength, pain intensity
      and functional level. Finally pre and post recordings will be compared and analyzed
      statistically.
    


Intervention name(s): Mobilization with movement; Soft Tissue Mobilization
Intervention type(s): Other; Other
Intervention description(s): Heating fermentation was done for 10 minutes as baseline treatment. MWM with wrist extension was given for alternative days in a week as per 3 sessions per week for 4 weeks.; Heating fermentation was done for 10 minutes as baseline treatment. Parallel and longitudinal massage was given for alternative days in a week as per 3 sessions per week for 4 weeks
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
A Phase 2 Clinical Study of KHK4827
Condition: Moderate to Severe Plaque Psoriasis
MeSH terms: Psoriasis
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is designed to evaluate the efficacy and safety of KHK4827 in subjects with
      moderate to severe plaque psoriasis in a randomized, double-blind, placebo-controlled,
      parallel group study. Pharmacokinetics of KHK4827 will also be assessed.
    


Intervention name(s): KHK4827; Placebo
Intervention type(s): Drug; Drug
Intervention MeSH terms: Brodalumab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Preventing Propofol-associated Injection Pain
Condition: Pain
Study type: Interventional
Phase: Phase 4

Summary: 
      Injection of propofol is associated with discomfort in subsets of patients. Local anesthetics
      have been shown to attenuate this response in some patients. This randomized, double-blind,
      placebo-controlled trial tests the hypothesis that lidocaine mixed with propofol will be
      superior to lidocaine administered directly into the vein, under tourniquet control, prior to
      injection of propofol. Both groups are expected to be superior to placebo.
    


Intervention name(s): Saline; Lidocaine / propofol admixture; lidocaine pretreatment
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 3.3 mL normal saline; lidocaine 50 mg plus propofol 50 mg intravenous (iv); lidocaine 50 mg iv under tourniquet-control
Intervention MeSH terms: Lidocaine; Propofol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: propofol; lidocaine; injection pain
CC100: Safety and Tolerability of Single Doses
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to see if CC100, given by mouth, is safe and is tolerated in
      increasing doses. How long the drug remains in the body will also be calculated.
    

Detailed description: 
      Approximately 18 healthy subjects will be randomized to receive by mouth either 3 single
      increasing doses of CC100 or 1 dose of placebo and 2 increasing doses of CC100. Dosing will
      occur every 2 to 7 days for a study duration of 5 to 15 days from the 1st dose. Subjects are
      required to stay in the Clinic for approximately 24 hours following each dose. Subjects may
      choose to have an optional lumbar puncture following the 3rd dose of study drug.
    

Intervention name(s): CC100; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): CC100 reconstituted in diluent; Diluent. Amount to match CC100 dose.
Other intervention name(s): synthetic caffeic acid phenethylester; Inactive vehicle
Intervention MeSH terms: Caffeic acid
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: Phase 1; Healthy Volunteer; Safety; Healthy Volunteer Safety Study
Do Some Healthy Adults Consistently Have Systemic Reactions to Influenza Vaccines?
Condition: Influenza
MeSH terms: Influenza, Human
Study type: Interventional
Phase: Phase 4

Summary: 
      This study will recruit 35 healthcare workers who had systemic reactions to influenza vaccine
      the last 2 times they were vaccinated, to ask whether influenza vaccine is indeed associated
      with systemic reactions in these workers.
    

Detailed description: 
      Randomized controlled trials of split virus vaccines in healthy adults have not been able to
      detect an increase in systemic adverse events compared to control vaccination. These trials
      do identify a non-trivial risk of systemic symptoms occurring in the week after both placebo
      and vaccine. There is a small population of healthcare workers who report consistent systemic
      symptoms after split virus vaccination which may occur because a small group of healthy
      adults have true physical reactions to components of the vaccine or excipients. If this is
      true, then alternatives - such as the use of subunit vaccines or live attenuated nasal spray
      vaccines - might be expected to be better tolerated by these people.
    

Intervention name(s): Vaccine
Intervention type(s): Biological
Intervention description(s): Licensed trivalent inactivated influenza vaccine
Other intervention name(s): Trivalent inactivated influenza vaccine
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: influenza vaccine; adult; safety; reactogenicity
Oral Health-related Patterns of Food Selectivity in Dental Populations
Condition: Oral Disease; Food Selection
MeSH terms: Mouth Diseases
Study type: Observational

Summary: 
      The present study was undertaken in order to describe the clinical profiles of food selective
      behavior in 35-65 years dental and non-dental populations.
    

Detailed description: 
      The study population included 125 participants, recruited within the general population and
      in a dental clinic: -Non-dental group included 62 non-seeking dental treatment subjects, aged
      30-65 years, previously recruited during the OralPom survey. -Dental group included 63
      patients recruited from September 2019 to December 2020 among patients seeking/pending dental
      treatment within the university dental clinic of the Rothschild hospital (AP-HP Sorbonne
      University, Paris, France).

      Both groups took part in an individual session with a dental practitioner during which food
      selectivity, medical history, and oral health status were assessed.
    

Intervention name(s): Clinical oral examination; Food behavior
Intervention type(s): Diagnostic Test; Diagnostic Test
Intervention description(s): Clinical oral examinations are conducted by a dental practitioner. They point out the number of teeth (ranging from 0 to 32), the number of occlusal functional units (OFU, ranging from 0 to 10, with one unit considered as a pair of antagonist premolars and molars that had at least one contact area during maximum intercuspal relationships, evaluated by asking the participants to clench on a 200 µm thick articulating paper, the presence of dental prostheses (fixed prosthesis and removable denture), the number of denture worn during meals (removable partial or complete denture, either maxillary or mandibular, or both, with number ranging from 0 to 2), the number of decayed, missing, filled teeth (DMFT index, based on 28 teeth), and the Russel's periodontal index which is presently preferred to the Community (namely CPITN) because it takes tooth mobility into account.; Food selective behavior is assessed using a food selectivity questionnaire previously developed for French adults 34. Participants will be interviewed and asked to check each food item they do not eat among a list of 71 familiar products which includes raw foods and dishes from the following categories: starters, meat, fish, egg, garnish, dairy products, desserts, bread, and beverages. A food selectivity score corresponding to the total number of avoided foods will be assessed for each participant. For each avoided food, participants explain why they do not eat it among reasons including "I don't know it", "I dislike it", "I suffer from chewing or swallowing it (oral discomfort)", "I experience difficulties digesting the food", "This food is forbidden for medical reason", and "This food is forbidden for ethical or religious reasons".
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        French adults, aged from 30 to 65 years old.
      
Keywords: eating behavior; food preferences
Optical Measurement of Cerebral Hemodynamics in Children With Acute Arterial Ischemic Stroke
Condition: Acute Arterial Ischemic Stroke
MeSH terms: Stroke; Ischemic Stroke; Cerebral Infarction; Ischemia
Study type: Observational

Summary: 
      Acute ischemic stroke affects roughly 1 in 50,000 children every year and is one of the top
      ten causes of death in children. Currently, caregivers lay the affected child flat in hopes
      of increasing blood flow to the brain and reducing the volume of the brain which is damaged.
      However, there are currently no techniques to measure brain blood flow at the child's bedside
      and indicate if this treatment is effective. We will probe brain blood volume, oxygen
      saturation, and flow with red light to determine the efficacy of this intervention.
    

Detailed description: 
      Arterial ischemic stroke (AIS) affects about 2 children per 100,000 per year and is one of
      the top 10 causes of mortality in children. After stroke, there is a disturbance in cerebral
      blood flow (CBF) autoregulation, and changes in head position may change CBF. Currently,
      practice at the Children's Hospital of Philadelphia (CHOP) is to keep the head of bed (HOB)
      of a child with AIS flat for 24 hours; however, there is no evidence that this practice is
      efficacious in children. Furthermore, maintaining a child supine for 24 hours is
      uncomfortable for the child and is often unenforceable in younger children. This study will
      use a noninvasive optical technique to measure CBF as HOB position is changed to assess the
      effectiveness of head of bed position in increasing CBF in children with acute arterial
      ischemic stroke.

      The primary objectives are to determine the difference in CBF at HOB flat (0 degrees) and HOB
      at +30 degrees in healthy children and in children with AIS. The secondary objectives are to
      examine CBF in healthy children and in children with AIS at other HOB angles (0, +15, and +30
      degrees) compared to the CBF at HOB 0 degrees and to determine if the position that maximizes
      CBF varies over time from stroke onset.
    

Observational model: Other
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Children (2-18 y.o.) presenting at the Children's Hospital of Philadelphia with a confirmed
        arterial ischemic stroke
Yoga in Controlling Symptoms and Reducing Stress in Women With Ovarian Cancer or Breast Cancer
Condition: Breast Cancer; Fatigue; Ovarian Cancer; Psychosocial Effects of Cancer and Its Treatment
MeSH terms: Breast Neoplasms; Ovarian Neoplasms; Carcinoma, Ovarian Epithelial; Fatigue
Study type: Interventional

Summary: 
      RATIONALE: Yoga may improve symptoms and quality of life and reduce stress in patients with
      ovarian cancer or breast cancer and may help them live more comfortably.

      PURPOSE: This clinical trial is studying how well yoga works in controlling symptoms and
      reducing stress in women with ovarian cancer or breast cancer.
    

Detailed description: 
      OBJECTIVES:

        -  Determine the feasibility of implementing a restorative yoga intervention as a
           complementary supportive therapy for women with ovarian or breast cancer.

        -  Measure changes in fatigue, psychosocial distress (anxiety, depression), psychological
           well-being (positive emotions), and overall quality of life from baseline to completion
           of the study treatment.

      OUTLINE: This is a pilot study.

      Patients undergo a 75-minute restorative yoga session once a week for 10 weeks.

      Patients complete questionnaires regarding fatigue, psychological distress (anxiety,
      depression), positive affect, and quality of life at baseline, immediately after the final
      yoga session, and then at 2 months after the final yoga session.
    

Intervention name(s): yoga therapy
Intervention type(s): Procedure
Intervention description(s): 10 week yoga class
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: fatigue; psychosocial effects of cancer and its treatment; recurrent breast cancer; stage I breast cancer; stage II breast cancer; stage IIIA breast cancer; stage IIIB breast cancer; stage IIIC breast cancer; stage IV breast cancer; recurrent ovarian epithelial cancer; recurrent ovarian germ cell tumor; stage I ovarian epithelial cancer; stage I ovarian germ cell tumor; stage II ovarian epithelial cancer; stage II ovarian germ cell tumor; stage III ovarian epithelial cancer; stage III ovarian germ cell tumor; stage IV ovarian epithelial cancer; stage IV ovarian germ cell tumor
Exploration of Clonal Hematopoiesis of Indeterminate Potential in Non-ischemic Heart Failure With Reduced Ejection Fraction
Condition: Heart Failure With Reduced Ejection Fraction
MeSH terms: Heart Failure
Study type: Observational

Summary: 
      Clonal hematopoiesis of indeterminate potential (CHIP) refers to a phenomenon in which blood
      cells with somatic mutation circulate in the peripheral blood due to abnormal proliferation
      and differentiation of mutant hematopoietic cells.

      CHIP is considered one of the aging phenomena, and the mutant blood cells increased by CHIP
      cause chronic inflammation, thereby increasing the occurrence of atherosclerotic
      cardiovascular disease. Therefore, CHIP is known to be closely related to poor prognosis of
      ischemic heart failure. Meanwhile, chronic inflammation may be involved in the development of
      non-ischemic myocardial disease, which is one of the major causes of heart failure.

      This study will identify CHIP and perform NLRP3 inflammasome assay in 100 non-ischemic heart
      failure patients and evaluate the relationship between CHIP and inflammation, imaging markers
      of heart failure, Left ventricle reverse remodeling after guideline-directed medical
      treatment, and prognosis of heart failure with reduced ejection fraction.
    


Observational model: Other
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients who need ACEI for cardiovascular disease
Lyrica Dose Response Study With Restless Legs Syndrome (RLS) Patients
Condition: Restless Legs Syndrome
MeSH terms: Psychomotor Agitation; Restless Legs Syndrome; Syndrome
Study type: Interventional
Phase: Phase 2

Summary: 
      To test the effectiveness and tolerability of Lyrica at various dose levels in RLS patients
    


Intervention name(s): placebo; Pregabalin; Pregabalin; Pregabalin; Pregabalin; Pregabalin
Intervention type(s): Drug; Drug; Drug; Drug; Drug; Drug
Intervention description(s): Placebo control (capsule), once a day, 1- 3 hours before bedtime for 6 weeks; 50 mg (capsule) per day, 1 - 3 hours before bedtime for 6 weeks; 100 mg (capsule) per day, 1 - 3 hours before bedtime for 6 weeks; 150 mg (capsule) per day, 1 - 3 hours before bedtime for 6 weeks; 300 mg (capsule) per day, 1 - 3 hours before bedtime for 6 weeks; 450 mg (capsule) per day, 1 - 3 hours before bedtime for 6 weeks
Other intervention name(s): Sugar pill; Lyrica, PD 0144723; CI-1008; Lyrica, PD 0144723; CI-1008; Lyrica, PD 0144723; CI-1008; Lyrica, PD 0144723; CI-1008; Lyrica, PD 0144723; CI-1008
Intervention MeSH terms: Pregabalin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: pregabalin, RLS, efficacy, safety
A Study to Compare PK, PD and Safety of the AD-214 and AD-2141
Condition: Gastroesophageal Reflux Disease
MeSH terms: Gastroesophageal Reflux
Study type: Interventional
Phase: Phase 1

Summary: 
      A study to compare safety, pharmacokinetics and pharmacodynamics of AD-214 to AD-2141 in
      healthy volunteers.
    

Detailed description: 
      This study is to compare the safety, pharmacokinetic characteristics and pharmacodynamics
      characteristics of AD-214 compared with administration of AD-2141 in healthy volunteers.
    

Intervention name(s): AD-214; AD-2141
Intervention type(s): Drug; Drug
Intervention description(s): 1 tablet administered before the breakfast during 7 days; 1 tablet administered before the breakfast during 7 days
Other intervention name(s): Test drug; Reference Drug
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Best Cardiac Output During Cardiopulmonary Bypass
Condition: Bypass Complications
Study type: Observational

Summary: 
      The purpose of this study is to determine whether the patients cardiac output measured before
      cardiopulmonary bypass (CPB), is more sufficient to secure the patients oxygen needs than the
      estimated cardiac output from Ficks principle, and thereby prevent organ failure.
    

Detailed description: 
      For more than 50 years, CPB has been used to mechanically support the functions of the heart
      and lungs. In early studies, systemic oxygen uptake, calculated using Ficks global principle,
      was used to assess the efficiency of CPB. Using this measure of efficiency, a pump flow rate
      in liters per minute, based on the product of the body surface area (BSA) and a constant of
      2.4 was found adequate to perfuse the body during normothermia. Ficks global principle is
      still used together with other methods to secure adequated perfusion under CPB.

      The purpose of this study is to determine whether the patients cardiac output measured before
      CPB, is more sufficient to secure the patients oxygen needs than the estimated cardiac output
      from Ficks principle, and thereby prevent organ failure.

      The hypothesis is that the patients cardiac output is a better marker for the optimal cardiac
      output than the estimated cardiac output.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients to be admitted to Aalborg Hospital, department of cardiac surgery for scheduled
        cardiac surgery
      
Keywords: cardiopulmonary bypass; cardiac output; flow rate; lactate
Motivational Interviewing to Promote Sustained Breastfeeding
Condition: Breastfeeding
Study type: Interventional

Summary: 
      1. Evaluate the cultural appropriateness of an intervention protocol related to: a)
           motivational interviewing technique; b) stool, urine, and breast milk sample collection;
           and c) infant breastfeeding test weight procedure.

        2. Compare Motivational Interviewing with an attention intervention (infant safety) on: a)
           breastfeeding self-efficacy, b) intended length of breastfeeding, and c) duration of
           breastfeeding.

        3. Examine urine samples of infants for the presence of the inflammatory cytokine (LTE4)
           and evaluate fecal and breast milk samples of infants for human milk oligosaccharide
           levels.
    

Detailed description: 
      The incidence of asthma, the most common serious chronic inflammatory disease among children,
      is rising each year. Therefore nursing interventions aimed at promoting infant immunity and
      mitigating factors to which the infant may be exposed may reduce the complications of this
      chronic illness. Breastfeeding is an ideal initial prevention strategy that strengthens the
      infant's immune system. In addition, the identification of biomarkers that reflect infant
      immune response sets the stage for the evaluation of nursing interventions targeted to
      decrease the impact of this chronic inflammatory disease. Although more mothers currently
      initiate breastfeeding, they do not sustain breastfeeding for the recommended 6 to 12 months.
      In general, Native American mothers' breastfeed for a shorter period of time and mothers in
      rural setting have fewer resources to support breastfeeding.
    

Intervention name(s): Motivational Interviewing
Intervention type(s): Behavioral
Intervention description(s): Client-centered strategy that may decrease ambivalence in behavior performance with attention intervention (infant safety) on: a) breastfeeding self-efficacy, b) intended length of breastfeeding, and c) duration of breastfeeding.
Other intervention name(s): Counseling
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: Breastfeeding; Self-efficacy; Motivational Interviewing
A Study Investigating Lu AG06466 in Healthy Men
Condition: Healthy Volunteers
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to investigate how the drug Lu AG06466 is absorbed, metabolized,
      and excreted from the body, for example, what the body does to the drug after swallowing a
      single dose.
    

Detailed description: 
      Researchers will measure the levels of the drug and its breakdown product in each
      participants blood for up to 5 days after dosing. Radioactivity in urine and feces will be
      measured for up to 3.5 weeks after dosing.
    

Intervention name(s): [14C]-Lu AG06466
Intervention type(s): Drug
Intervention description(s): [14C]-Lu AG06466 will be administered per schedule specified in the arm description.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment