bioihbjkbjnl/mcl2 huggingface dataset:
Blood Flow Change After Free Flap Surgery in Diabetic Patients
Condition: Diabetes
Study type: Observational

Summary: 
      We aim to evaluate the flow change of arterial anastomosis site during free flap surgery in
      diabetic patients.
    

Detailed description: 
      Objective: flow change of arterial anastomosis site during free flap surgery in diabetic
      patients.

      Background: No research was published about flow change of arterial anastomosis site of the
      free flap during surgery.

      Plan: Using Duplex sonography, various parameters related flap perfusion will be evaluated
      before and after the administration of alprostadil.
    

Intervention name(s): Alprostadil
Intervention type(s): Drug
Intervention description(s): Vasodilator for anastomosis-site of free flap
Other intervention name(s): Eglandin
Intervention MeSH terms: Alprostadil
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Diabetic patients who are undergoing free flap surgery
Multi-Center Trial of Anti-Thymocyte Globulin in Treatment of Aplastic Anemia and Other Hematologic Disorders
Condition: Anemia, Aplastic; Hematologic Diseases; Pancytopenia; Blood Disease
MeSH terms: Anemia; Hematologic Diseases; Anemia, Aplastic; Pancytopenia
Study type: Interventional
Phase: Phase 3

Summary: 
      To determine the therapeutic effects of anti-thymocyte globulin (ATG) in patients with
      aplastic anemia and related bone marrow failure diseases.
    

Detailed description: 
      BACKGROUND:

      Aplastic anemia has been shown to respond to ATG. An immunological basis for aplastic anemia
      has been suggested by previous observations although the precise mechanism of action of ATG
      has not been defined. This serum, produced by immunization of horses with human thymocytes,
      may have broad reactivity with many human cells.

      DESIGN NARRATIVE:

      Patients in Group I with acute severe disease were randomized to receive ATG in either ten
      day or twenty-eight day courses. Patients in Group II with moderate or chronic disease were
      randomized to receive either ATG for ten days or high doses of the androgen, nandrolone
      decanoate. Patients in Group III with a variety of bone marrow diseases were also treated
      with ATG.

      The study completion date listed in this record was inferred from the last publication listed
      in the Citations section of this study record.
    

Intervention name(s): antilymphocyte serum; nandrolone
Intervention type(s): Drug; Drug
Intervention MeSH terms: Nandrolone Decanoate; Nandrolone; Nandrolone phenpropionate; Antilymphocyte Serum
Allocation: Randomized
Primary purpose: Treatment
Duration of Platelet Inhibition by Aspirin
Condition: Coronary Artery Disease
MeSH terms: Coronary Artery Disease
Study type: Observational

Summary: 
      The well established importance of regular aspirin administration stands on firm grounds, as
      large meta-analyses have shown this therapy to significantly reduce the risk of death.
      However, not all patients benefit of aspirin administration to the same extent, thus
      high-lighting a sub-population of patients with inadequate platelet response to ASA. The
      mechanisms underlying reduced ASA efficacy remain elusive. A recent report has suggested that
      platelets, long believed to be incapable of de novo protein synthesis, may retain their
      ability to form the cyclooxygenase enzyme, once it has been inactivated by aspirin. This may
      explain the inefficacy of the drug to induce sustained platelet inhibition in certain
      patients.

      The current study aims to evaluate, in patients suffering from stable coronary artery
      disease, the stability of platelet inhibition by aspirin during the normal once daily dosing
      regimen.
    


Intervention name(s): Platelet aggregation
Intervention type(s): Other
Intervention description(s): Platelet aggregation TxA2 formation
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Patients suffering from stable CAD, on chronic ASA therapy
      
Keywords: platelet aggregation; aspirin
Hyperbaric Oxygen and Manipulative Therapies to Regain Function Post Stroke
Condition: Stroke; Motor Dysfunction; Chronic Stroke; Ischemic Stroke
MeSH terms: Stroke; Ischemic Stroke
Study type: Interventional
Phase: Early Phase 1

Summary: 
      To study safety, feasibility and outcomes of combining osteopathic manipulative therapies
      with hyperbaric oxygen therapy in reducing the functional deficits in stroke survivors in
      subacute and chronic phases post ischemic stroke. To document the same as part of a pilot
      project in anticipation of further investigational studies.
    

Detailed description: 
      The primary objective of this study is to show that hyperbaric oxygen therapy combined with
      osteopathic manipulative therapies improve outcomes in patients who have persistent
      neurological deficits after ischemic stroke compared to historical norms.

      The secondary objectives of this study is to demonstrate safety and feasibility of treating
      patients post stroke with hyperbaric oxygen and osteopathic therapies as well as determine
      improvements in multiple assessment scales of motor function, depression, activities of daily
      living(ADL) and pain
    

Intervention name(s): HBOT and OMT
Intervention type(s): Combination Product
Intervention description(s): Hyperbaric oxygen therapy (HBOT) is defined as breathing 100% oxygen at increased atmospheric pressure. Osteopathic manipulative therapy (OMT) is used for myriad ailments including contractures, pain, spasticity. Patients in intervention arms will receive hyperbaric oxygen therapy at 2ATM (atmospheres) for 90minutes daily for up to 6weeks. In addition, they will receive osteopathic manipulative therapies twice a week during the same treatment phase.
Other intervention name(s): Osteopathic manipulative therapies (OMT); Hyperbaric Oxygen Therapy (HBOT)
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: There will be two populations based on when they experienced a stroke. Subacute stroke patients will have suffered an ischemic stroke within 3 months of enrollment and have persistent neurological deficits. The second group will be patients who suffered an ischemic stroke more than 6 months (chronic) from time of enrollment and have persistent neurological deficits compromising activities of daily living.
Masking: None (Open Label)
Primary purpose: Treatment
The Association Between Body Constitution and Meridian Energy in Prediabetes
Condition: Prediabetes
MeSH terms: Prediabetic State; Glucose Intolerance
Study type: Observational

Summary: 
      Traditional Chinese medicine (TCM) theories assert that body constitution and meridian energy
      are the foundations for disease prevention. However, few studies have incorporated TCM
      concepts into risk factors. This study aimed to examine the association between body
      constitution and meridian energy in individuals with prediabetes. We conducted a matched
      case-control study that included 60 individuals with prediabetes. Finally, the reseachers
      have found that body constitution may be a risk factor fpr progression to type 2 diabetes
      mellitus in individuals with prediabetes.
    

Detailed description: 
      Objective: Traditional Chinese medicine (TCM) theories assert that body constitution and
      meridian energy are the foundations for disease prevention. However, few studies have
      incorporated TCM concepts into risk factors. This study aimed to examine the association
      between body constitution and meridian energy in patients with prediabetes.

      Methods: The researchers conducted a matched case-control study from January to December 2019
      that included 30 adults with prediabetes and 30 healthy controls, matched for age and sex,
      recruited from the outpatient clinic and health examination center at a teaching hospital in
      northern Taiwan. Body constitution was measured using the Body Constitution Questionnaire,
      which classifies the constitution as yang-deficiency, ying-deficiency, and phlegm-stasis,
      while meridian energy was measured using an Aetoscan meridian energy device (Aeto Technology
      Co. Ltd., Taiwan). The associations between body constitution, meridian energy, and
      prediabetes were examined using binary logistic regression analyses.

      Conclusion: Body constitution may be a risk factor for progression to type 2 diabetes
      mellitus in patients with prediabetes and warrants further study.
    

Intervention name(s): Routine care
Intervention type(s): Other
Intervention description(s): Both two groups received the same routine care.
Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        The researchers included 30 adults with prediabetes and 30 healthy controls, matched for
        age and sex, recruited from the outpatient clinic and health examination center at a
        teaching hospital in northern Taiwan.
      
Keywords: prediabetes; traditional Chinese medicine; body constitution
Study to Evaluate Implant Survival Rate of Astra Tech Fixture ST in the Posterior Maxilla With One-stage Surgery and Early Loading
Condition: Jaw, Edentulous, Partially
MeSH terms: Jaw, Edentulous; Jaw, Edentulous, Partially
Study type: Interventional

Summary: 
      The purpose of this study is primarily to evaluate implant survival rate of Astra Tech
      Fixture ST placed in the posterior maxilla. A one-stage surgical protocol will be used and
      the implants will be loaded four weeks after implant installation (early loading). Marginal
      bone levels, plaque and status of the periimplant mucosa will also be evaluated. The subjects
      will be followed for three years.
    


Intervention name(s): Astra Tech Fixture ST
Intervention type(s): Device
Intervention description(s): Astra Tech Fixture ST Ø 3.5 and 4.5 cm in lengths of 9, 11, 13, 15, 17 and 19 mm.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Risperidone and Suicidality in Major Depressive Disorder
Condition: Depression
MeSH terms: Depressive Disorder; Depressive Disorder, Major; Suicidal Ideation
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this trial is to investigate the efficacy of risperidone as an adjunct to an
      antidepressant treatment in the acute management of suicidality during an episode of major
      depressive disorder.
    

Detailed description: 
      Using a double blind, placebo-controlled design, subjects diagnosed with a current episode of
      major depressive disorder (defined by DSM-IV criteria and supported by the Mini International
      Neuropsychiatric Interview), severe with suicidality despite currently taking an
      antidepressant, will be enrolled in the eight-week study. The treatment will be initiated by
      randomizing patients to receive risperidone or placebo in addition to the antidepressant that
      the patient is already taking. The clinical efficacy will be evaluated after 4 days, weekly
      for 4 weeks, then every other week for 4 weeks with the efficacy measures. During the
      eight-week study, treatment with risperidone or placebo will continue at the highest
      effective dosage (up to 2 mg per day). The dose of the antidepressant will not be changed
      during the study.
    

Intervention name(s): Risperidone and placebo comparator
Intervention type(s): Drug
Intervention description(s): Up to 2 mg risperidone or matching placebo daily
Intervention MeSH terms: Risperidone
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: suicidality; antipsychotic; antidepressant; treatment
LLLT for Alopecia of the Eyebrow in Women
Condition: Alopecia
MeSH terms: Alopecia; Alopecia Areata
Study type: Interventional

Summary: 
      The purpose of this research is to study the ongoing effectiveness of a light therapy device
      for human hair growth. This device, called the iRestore Eyebrow Device, is a type of cold, or
      non-heat producing light therapy system that will emit light on the hair growth cells within
      and around the hair follicle. When these cells do not function properly, one may experience
      common problems such as baldness and thinning or brittle hair. The application of a special
      category of low-level light to be studied in the project may cause an increase in essential
      nutrients to the damaged hair follicles and skin cells, leading to a reduction in hair loss
      and in some cases, possibly leading to re-growth.
    

Detailed description: 
      This study on LLLT aims to define the safety and physiologic effects that occur when the
      human hair follicle and surrounding tissue structures are exposed to this type of radiation.
      Thus far, all reports on the efficacy of laser light and LED light in this area, have been,
      in large part, unsupported by multi-center, randomized, double blind, controlled studies. To
      properly identify the effects in human subjects, exposure to LLLT is not sufficient. The
      analysis of the non-radiated and radiated tissues is required to elucidate the tissue
      response and efficacy of the laser therapy. The theory that is widely accepted is that the
      mitochondria are the powerhouse of the stem cells that cause hair growth. The LLLT "turns on"
      the nutrient pump process that energizes the mitochondria, which leads to an increase in ATP
      and subsequent reversal of hair follicles from the dormant stage of growth called telogen, to
      the active growth stage called anagen.
    

Intervention name(s): LLLT
Intervention type(s): Device
Intervention description(s): This is a low-level light (LED) device configured in the shape of a headband, operating at 650 +/-10 nanometers and 940 +/- 10 nanometers, that contains 12 of each wavelength for a total of 24 LEDs.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Study to Investigate the Influence of MK0859 on Blood Pressure (MK-0859-012)(COMPLETED)
Condition: Ambulatory Blood Pressure
Study type: Interventional
Phase: Phase 1

Summary: 
      This study will investigate the influence of MK0859 on ambulatory blood pressure, and how
      safe and tolerable MK0859 is on the subjects This is an early phase trial and some specific
      protocol information is in progress and not publicly available at this time. (Full
      information is available to trial participants).
    


Intervention name(s): MK0859
Intervention type(s): Drug
Intervention MeSH terms: Anacetrapib
Validation of Child Drawing Hospital Scale (CD: H) and the Place of the Drawing in the Evaluation of Dental Anxiety
Condition: Dental Anxiety; Dental Pain; Validation; Child Drawing Hospital Scale
MeSH terms: Anxiety Disorders
Study type: Interventional

Summary: 
      Objectives: Our study aimed to perform a Turkish validation study of the Child Drawing:
      Hospital (CD:H) Scale and evaluate the dental anxiety and pain experienced during the
      treatment by drawing.

      Study Design: Pediatric patients between the ages of 4-13 who applied to the Pediatric
      Dentistry Department between 2018-2020 were included in the study. Following the translation
      of the CD:H Scale into Turkish and linguistic-cultural validation, the behaviors of pediatric
      patients during treatment were evaluated with the Frankl Behavior Rating Scale, the pain they
      experienced during treatment with the Wong- Baker Face Rating Scale, and their anxiety levels
      were evaluated with the pictures drawn by the patients at the end of the treatment. The data
      were analyzed with Statistical Package for the Social Sciences v23, and the significance
      level was taken as p <0.05.

      Results: Within the scope of the scale's reliability-validity study, the Intra-Class
      Correlation Coefficient (ICC) was evaluated with test-retest consistency. For section A,B,C
      and total score reliability was found to be positive and strong level correlation. Dental
      anxiety of boys was higher than girls.

      Conclusions: The Turkish version of the CD:H Scale is a reliable and valid scale that can be
      used to evaluate the dental anxiety of Turkish pediatric patients.
    


Intervention name(s): survey research
Intervention type(s): Behavioral
Intervention description(s): Children with dental treatment were asked to draw pictures.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
Neuroendocrine Mechanisms in Behavioral Treatment of Insomnia
Condition: Insomnia
MeSH terms: Sleep Initiation and Maintenance Disorders
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to evaluate the change in measures of physiological arousal
      before and after behavioral treatment of insomnia.
    

Detailed description: 
      There is good evidence that physiological arousal, associated with sustained activation of
      the hypothalamic-pituitary axis and the sympathetic nervous system, is an underlying cause of
      chronic insomnia. Accordingly, relaxation-related treatments that address elevated cognitive
      and somatic arousal have been effective for insomnia. Previous studies have documented the
      effectiveness of behavioral treatments in reducing activation of the hypothalamic-pituitary
      axis and the sympathetic nervous system and in the treatment of specific medical disorders
      including insomnia. The aim of this proposal is to evaluate the hypothesis that improvements
      in chronic psychophysiological insomnia following a behavioral treatment are tightly
      associated with reduction of arousal in the hypothalamic-pituitary axis, as measured by
      plasma cortisol, and in the sympathetic nervous system, as measured by urinary
      catecholamines. Objective measures of sleep will be derived from polysomnographic recordings
      from subjects randomized into a 10-week active behavioral treatment or placebo behavioral
      control treatment group. Continuous 24-hour evaluation of cortisol and catecholamines will be
      performed under controlled laboratory conditions before and after treatment. We anticipate
      significant reductions in cortisol and catecholamines in the active treatment group as
      compared with the control group. We also anticipate that the active treatment will yield
      reductions in related measures of arousal including heart rate, autonomic arousal (as
      determined from heart rate variability), and body temperature. Given reported evidence that
      melatonin levels are chronically low in insomnia we anticipate an increase in the
      sleep-related hormone melatonin in the yoga treatment group. If achieved, these results will
      provide a novel demonstration of a reduction of arousal in a behavioral insomnia treatment
      and a behaviorally enhanced melatonin secretion under controlled laboratory conditions.
    

Intervention name(s): mind body treatment; desensitization
Intervention type(s): Behavioral; Behavioral
Intervention description(s): regulation of attention, respiration and posture; mentation on insomnia behaviors and cognitive activity
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: sleep; arousal; stress; cortisol; catecholamines
AVANDAMET Versus Metformin And Sulphonylurea In People With Poorly Controlled Type 2 Diabetes
Condition: Non-Insulin-Dependent Diabetes Mellitus
MeSH terms: Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 3

Summary: 
      This study compares the effects of Avandamet (rosiglitazone maleate/metformin) treatment and
      metformin plus sulphonylurea treatment in overweight people with type 2 diabetes.
    


Intervention name(s): metformin; sulphonylurea; Avandamet
Intervention type(s): Drug; Drug; Drug
Other intervention name(s): metformin; sulphonylurea
Intervention MeSH terms: Metformin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Primary purpose: Treatment
Keywords: Type 2 diabetes; overweight; AVANDAMET; metformin; sulphonylurea
"Effects of Manual Lymphatic Drainage in the Neck in Healthy Subjects. Experimental Randomized Crossover Study"
Condition: Blood Pressure; Nervous System Diseases, Sympathetic; Heart Rate Low; Lymphatic Diseases
MeSH terms: Nervous System Diseases; Autonomic Nervous System Diseases; Bradycardia; Lymphatic Diseases
Study type: Interventional

Summary: 
      Drainage manoeuvres described in different Manual Lymphatic Drainage methods, suggest
      modificactions in vital signs, by changes at nervous system, that would involve modifications
      to heart rate, breathing rate, blood pressure, cardiac vascular level (arteries and
      lymphatics). In addition this hypothetical relaxing effect could be beneficial for other
      types of pathologies associated with the presence of stress, cardiac problems, respiratory
      pathology, muscle tension, muscle trigger points, etc. With this study investigators compare
      different manoeuvres in the neck area to observe the results in the participants regarding
      the basal state.
    

Detailed description: 
      Differentes drainage manoeuvres suggest changes at nervous system (sympathetic and
      parasympathetic nervous system) and other vital constants
    

Intervention name(s): cervical stimuli; terminus; Placebo; Control group
Intervention type(s): Other; Other; Other; Other
Intervention description(s): Manouvres Godoy; Manouvres Vodder; placebo manouvre; lie down
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Endocan, VEGF and TNF-alpha Levels in Periodontal Disease and After Treatment
Condition: Periodontal Disease
MeSH terms: Periodontal Diseases
Study type: Observational

Summary: 
      The primer aim of the study was to determine serum and gingival crevicular fluid (GCF)
      endocan levels in periodontal diseases pathogenesis supported with vascular endothelial
      growth factor (VEGF) and tumor necrosis factor alpha (TNF-α) levels.
    

Detailed description: 
      The study consist of three groups: periodontally healthy individuals (group 1; n = 20),
      individuals with generalized chronic periodontitis (group 2; n = 20), the same patients with
      chronic periodontitis after they had been treated with scaling and root planing (SRP) were
      considered as Group 3. Clinical measurements were recorded; GCF and serum samples were
      obtained from each participant before and 6 weeks after therapy. Endocan, VEGF-A and TNF-α
      levels were measured by enzyme-linked immunosorbent assay.
    

Intervention name(s): Non-surgical periodontal treatment
Intervention type(s): Procedure
Intervention description(s): Non-surgical periodontal therapy is an anti-infective therapy which includes both mechanical and chemotherapeutic approaches to minimize or eliminate microbial biofilm, the primary etiology of gingivitis and periodontitis
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Total of 40 individuals
      
Biospecimen description: 
      Gingival crevicular fluid and Serum
    
Keywords: endocan protein; VEGF A; TNF-alpha; after treatment