bioihbjkbjnl/mcl2 huggingface dataset:
The Effect of Wound Problems Wound Dressing in Patients With Colorectal Cancer Surgery
Condition: Colorectal Cancer; Surgery; Surgery--Complications; Surgical Site Infection; Wound Complication
MeSH terms: Surgical Wound Infection; Colorectal Neoplasms; Wounds and Injuries
Study type: Interventional

Summary: 
      This study was conducted as a randomized controlled trial in order to determine the effect of
      prophylactic negative pressure wound therapy for the prevention of surgical site
      complications in high-risk colorectal cancer surgery.

      Hypothesis: Prophylactic negative pressure wound therapy applied after open colorectal cancer
      surgery to high-risk patients affects surgical wound complications.

      pNBYT group: The study was completed with a total of 50 patients, 24 of intervention group
      anda 26 of the control group, who met the inclusion criteria at the surgical oncology service
      of a university hospital.

      The data were collected using Patient Identification Form, Surgical Procedure Form, Wound
      Follow-up Chart and ASEPSİS Wound Scoring System. Ethics committee approval and written
      informed consent of the individuals was taken in the research.

      The data were analyzed in SPSS Statistics 24.0 program using Shapiro Wilk test and Q-Q
      graphs, Independent Sample t test, Mann Whitney U test, Chi-square, Cochran's Q and Friedman
      test. The value of p<0.05 was accepted for the statistical significance level. It was
      determined that the groups were similar in terms of identification and surgical procedure
      characteristics.
    

Detailed description: 
      The effects of negative pressure wound treatment applied to high-risk patients after open
      colorectal cancer surgery on four SWCs, including surgical site infections, hematoma, seroma,
      and wound dehiscence, were studied. The study started before surgery and lasted up to one
      month after surgery.

      Preoperatively, patients fasted for eight hours before the operation and were required to
      take a shower with 2% chlorhexidine gluconate at night. The patients who required surgical
      hair removal were shaved with a clipper in the operating room before the operation. Also,
      patients received 1g of ampicillin + sulbactam/cefazolin within 60 minutes before the
      incision.
    

Intervention name(s): pNBYT
Intervention type(s): Device
Intervention description(s): pNPWT device (80mm Hg) was placed in the pNPWT group for seven days The incision area was evaluated during the first seven days, and on the 15th, 21st, and 30th days postoperatively for the presence of hematoma, seroma, wound dehiscence/evisceration, and SSI.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: colorectal cancer; colorectal surgery; surgical site infection; surgical wound complication; negative pressure wound therapy
PK/PD of High Dose Pip/Tazo in Obese Patients
Condition: Obesity
MeSH terms: Obesity
Study type: Interventional

Summary: 
      Worldwide rates of obesity have doubled in the last 30 years, and obesity has been associated
      as a risk factor for hospital-acquired infections and increased occurrence of death in
      critically-ill patients. Piperacillin/tazobactam is a commonly prescribed antibiotic for
      critically ill patients with an infection, however, limited information exists for dosing
      this drug in obese patients. In these limited reports, standard doses of
      piperacillin/tazobactam given to the small number of obese patients resulted in lower blood
      concentrations, which could lead to inadequate killing of bacteria. The purpose of this study
      is to compare blood concentrations from standard piperacillin/tazobactam dosing compared to
      higher dosing regimens in obese patients. This study will also include information on the
      safety and tolerability of the higher dose regimens. The study investigators believe that the
      higher dosing regimen will produce adequate blood levels in obese patients and will not add
      any more risk of harm to obese patients receiving this higher dose.
    


Intervention name(s): Piperacillin/Tazobactam Standard Dose to High Dose
Intervention type(s): Drug
Intervention description(s): Patients will receive a standard dose of piperacillin/tazobactam, then will have subsequent pharmacokinetic analyses on the blood concentrations drawn while on standard dose. Patients will be switched to higher dose after receiving the standard dose, with subsequent pharmacokinetic analyses performed on those blood concentrations while on higher dose. These pharmacokinetics of each dosing regimen will be compared.
Other intervention name(s): Zosyn
Intervention MeSH terms: Tazobactam; Piperacillin; Piperacillin, Tazobactam Drug Combination
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: pharmacokinetics; obesity; piperacillin-tazobactam combination product; pharmacodynamics; piperacillin/tazobactam
A Study of r-PA Treating Patients With Acute Ischemic Stroke（RAISE）
Condition: Acute Ischemic Stroke
MeSH terms: Stroke; Ischemic Stroke; Cerebral Infarction; Ischemia
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to assess the efficacy and safety of recombinant human tissue
      plasminogen kinase derivatives for injection and alteplase in the treatment of patients with
      acute ischemic stroke within 4.5 hours.
    

Detailed description: 
      This study is a multicenter, randomized, blind endpoint and positive drug control study.

      The study plans to recruit 1412 AIS patients within 4.5 hours of onset. Qualified subjects
      are assigned to the test drug and control drug alteplase group according to the ratio of 1:1.
      After receiving thrombolytic drugs, the subjects need to carry out a series of safety and
      effectiveness tests. The mRS score and Barthel index score visits are carried out on the 90th
      day (± 7 days) after thrombolysis. After the visit, the subjects can leave the group.

      In this study, independent blind endpoint evaluators were set up in each research center to
      evaluate the mRS and Barthel index score 30 and 90 days after thrombolysis.
    

Intervention name(s): Injection of recombinant human tissue plasminogen kinase derivatives; Recombinant human tissue plasminogen activator
Intervention type(s): Drug; Drug
Intervention description(s): 18mg/10ml/stick, provided by Angde Biotech; 20mg/stick, 50mg/stick, provided by Shanghai Boehringer Ingelheim Pharmaceutical Co. Ltd.
Other intervention name(s): Reteplase; brand name: Ruitongli; r-PA; Alteplase; brand name: Actilyse; rt-PA
Intervention MeSH terms: Tissue Plasminogen Activator; Plasminogen; Reteplase
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Effect of Visceral Osteopathic Manipulations on Low Back Pain
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional

Summary: 
      Forty female patients with age ranging from 30-40 years old were suffering from low back pain
      due to visceral dysfunctions participated in this study. They were recruited from a private
      clinic. They were assigned into two groups equal in number; Group (A): included twenty
      patients who received osteopathic manipulative techniques, 1 session per week for 3 weeks,
      and Group (B): included twenty patients who received only analgesic drugs.
    

Detailed description: 
      Twenty patients received osteopathic manipulative techniques including Suboccipital release
      technique, diaphragmatic release.,mesentery release and Colonic manipulation were applied to
      the study group according to the patients' needs.

      The treatment program comprised a total of 3 sessions for 3 weeks at one session per week for
      an average of 50 minutes per session. Twenty patients in the second group (control ) took
      only analgesics during the three weeks.
    

Intervention name(s): Osteopathic manipulation
Intervention type(s): Other
Intervention description(s): Osteopathic manipulative techniques including; suboccipital release technique,sacral release technique, diaphragmatic release, mesentery release, and Colonic manipulation
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: A randomized, controlled, parallel study
Masking: Single (Outcomes Assessor)
Primary purpose: Supportive Care
OXIRI [Oxaliplatin (O), Xeloda (X) and Irinotecan (I)] in Pancreatic Adenocarcinoma
Condition: Pancreatic Cancer
MeSH terms: Adenocarcinoma
Study type: Interventional
Phase: Phase 1

Summary: 
      This is an exploratory Phase I study is to assess the safety and tolerability of the OXIRI
      regimen [oxaliplatin (O), xeloda (X) and irinotecan (I)] and to evaluate for preliminary
      evidence of efficacy, in patients with advanced and/or metastatic pancreatic adenocarcinoma.
      The investigators hypothesize that 2 of 3 weekly doses of oxaliplatin and genotype
      directed-dosing of irinotecan in combination with chronomodulated capecitabine (xeloda)
      administered continuously will be more tolerable than the FOLFIRINOX regimen (folinic acid,
      fluorouracil, irinotecan and oxaliplatin) while maintaining anti-tumour activity.
    

Detailed description: 
      This study comprises a dose escalation phase using 3+3 design to determine the safety,
      tolerability and pharmacokinetics of the OXIRI regimen and an expansion phase to further
      evaluate the MTD and to determine early signs of efficacy.

      Eligible patients will receive a novel chemotherapeutic regimen (OXIRI regimen) with xeloda
      being administered in a chronomodulated fashion and the dose of irinotecan being guided by
      the UGT1A1*28 and UGT1A1*6 genotype status of the patient.
    

Intervention name(s): oxaliplatin, irinotecan, capecitabine
Intervention type(s): Drug
Intervention description(s): fixed doses of intravenous oxaliplatin 50 mg/m2, and intravenous irinotecan administered on days 1 and 8 in a 21 day-cycle while xeloda will be administered daily at around midnight from day 1 to day 14
Other intervention name(s): Eloxatin, Camptosar, CPT-11, Xeloda
Intervention MeSH terms: Capecitabine; Oxaliplatin; Irinotecan
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of MK-8666 in Participants With Type 2 Diabetes Mellitus (MK-8666-003)
Condition: Type 2 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      This is a study of the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD)
      of MK-8666 in participants with type 2 diabetes mellitus (T2DM). Participants enrolled in
      this trial would be either treatment-naive or have washed off of oral anti-hyperglycemic
      agents. MK-8666 is planned to be administered orally for up to 2 weeks. The primary
      hypothesis for this study is that after 14 days of once daily treatment with MK-8666, at a
      dose that is safe and well tolerated, the placebo-corrected fasting plasma glucose reduction
      from baseline is ≥34 mg/dL.
    


Intervention name(s): MK-8666; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): MK-8666, capsules, oral, QD, Days 1 to 14; Placebo, capsules, oral, QD, Days 1 to 14
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
A Study of Two Different Formulations of LY3209590 in Healthy Participants
Condition: Healthy
Study type: Interventional
Phase: Phase 1

Summary: 
      The main purpose of this study is to look at the amount of the study drug, LY3209590, that
      gets into the blood stream and how long it takes the body to get rid of LY3209590 when given
      as different formulations. The tolerability of LY3209590 will also be evaluated and
      information about any side effects experienced will be collected. The study will last up to
      142 days.
    


Intervention name(s): LY3209590
Intervention type(s): Drug
Intervention description(s): Administered SC.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Physical Activity Tracking in Paediatric Elective Tonsillectomy
Condition: Tonsillectomy
Study type: Observational

Summary: 
      This pilot study will investigate the feasibility of physical activity tracking in patients
      aged 4-16 years before and after elective tonsillectomy as an innovative tool in paediatric
      research. The participating patients will receive a wearable physical activity tracker
      (CE-certified) that will continuously measure the patients' physical activity before and
      after an elective tonsillectomy, in addition to their parents' documentation of their child's
      activity in a conventional diary.
    


Observational model: Other
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Children undergoing elective tonsillectomy or tonsillotomy
Demonstration of the Presence of a Carbonyl Stress in the Hair Follicles of Postpartum Women
Condition: Telogen Effluvium
Study type: Interventional

Summary: 
      In this study, the investigator will try to highlight the presence of carbonyl compounds in
      the hair follicles of postpartum women by comparing these compounds before and after
      delivery.
    

Detailed description: 
      At the cutaneous level, oxidative stress induces the formation of carbonyl compounds which,
      by binding to proteins, produce non-functional adducts inducing cutaneous aging. This
      mechanism is called "carbonyl stress".

      During pregnancy, estrogen increases massively, stimulates the whole body and prolongs the
      life of the hair (slower passage in telogen phase).

      After delivery, estrogen levels drop, resulting in a massive and simultaneous hair loss that
      should have "naturally" fallen earlier. In addition, birth is a stressful stage for most
      moms. This stress and excessive fatigue and possibly a return to work may also be responsible
      for hair loss.

      Is the carbonyl stress also present in the scalp and can it be one of the mechanisms involved
      in the occurrence of postpartum hair loss? To demonstrate this, samples of hair follicles are
      taken. The proteins are extracted from the samples and then assayed. The oxidized (carbonyl)
      proteins are labeled with specific fluorescent probes
    

Intervention name(s): Hair follicles sampling
Intervention type(s): Other
Intervention description(s): The hair follicles will be collected by strand of 5 to 6 hairs approximately in the scalp (centro-parietal part), in order to obtain 20 follicles with epithelial sheath.
Intervention model: Sequential Assignment
Intervention model description: 2 sampling timepoints:
before delivery
after delivery
Masking: None (Open Label)
Primary purpose: Basic Science
A Retrospective Review of Enseal Laparoscopic Vaginal Assisted Hysterectomy (LAVH) Versus Traditional LAVH
Condition: Benign Uterine Disease
MeSH terms: Uterine Diseases
Study type: Observational

Summary: 
      Retrospective charts review from one surgeon to compare Group A- cases where the laparoscopic
      portion of the case used an EN~SEAL device to Group B - the laparoscopic BSO was done using a
      3mm EN-SEAL device through 2 lateral 5mm ports.
    

Detailed description: 
      79 women with benign uterine disease underwent laparoscopic assisted vaginal hysterectomy
      with or without bilateral salpingo-oophorectomy. Subjects charts were divided into two groups
      based on surgical technique and the following parameters were reviewed retrospectively:
      surgical time, blood loss, uterine weight, patient weight, patient age, post operative fever
      >100.4 F, readmission to hospital within one week, return to operating room within 24 hours,
      length of hospital stay, and blood transfusion. Group A, N=35 used traditional suture
      technique vaginally. Group B, N=44 used Enseal coagulation cutting device vaginally.
    

Intervention name(s): Laparoscopic assisted vaginal hysterectomy
Intervention type(s): Procedure
Intervention description(s): Surgical removal of uterus vaginally
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        patients who underwent Laparoscopically Assisted Vaginal Hysterectomy (LAVH)
      
Keywords: laparoscopic; vaginal; hysterectomy
Osseointegrated Transdermal Femoral Amputation Prostheses
Condition: Osseointegrated Implants; Bone Mineral Density
Study type: Interventional

Summary: 
      Femur amputated patients often suffer from several problems with conventional socket
      prosthesis. Some experience changes in gait, discomfort when sitting, altered skin conditions
      (infection, irritation, rashes, sweat), phantom pain or lack of stabilization between the
      prosthesis and the residual limb. Many have a low score on "health-related quality of life"
      questionnaires (HRQL).

      Some femur amputated patients may be a candidate to osseointegrated prosthesis.
      Osseointegrated prosthesis is an implant, where the fixture is inserted into the femur canal
      and an abutment screw, on which the leg-prostheses is inserted, protrudes the skin. By this
      procedure the patient have a high score on HRQL and experience fewer problems. They have
      improved gait, reduced discomfort when sitting, increased prosthetic use, and experience
      fewer skin and pain problems.

      Femur amputee patients formerly mobilized on socket prosthesis have a reduced bone mineral
      density in the affected femur and pelvis.

      The Phd-theses compromise of three studies. The aim of the first study is to follow patients
      with oosseointegrated prosthesis before and after surgery with DXA-scans to monitor the BMD.
      In the second study patients will be randomised to receive medical treatment with an
      RANKL-inhibitor, approved for treatment of osteoporosis, and monitored with DXA,
      microdialysis and radiostereometry. Depending on the DXA-results patients in the third study
      may receive fast track rehabilitation.

      The hypothesis is that patients with osseointegrated prosthesis will have an increased BMD
      after surgery, 2 years follow up. Patients receiving RANKL inhibitor will have increased BMD,
      stability of the prosthesis, and some receive fast-track rehabilitation due to high BMD.
    


Intervention name(s): Denosumab; Placebo
Intervention type(s): Drug; Drug
Intervention MeSH terms: Denosumab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Polyglucosamine L112 in Overweight and Obese Subjects
Condition: Obesity
MeSH terms: Overweight
Study type: Interventional

Summary: 
      This research proposes as its main purpose to evaluate the effectiveness of the intake of
      Polyglucosamine at a dose of 3 g / day on weight loss in a group of subjects suffering from
      overweight and mild obesity (BMI between 25 and 32 kg / m2). and with weight> 75 kg
    


Intervention name(s): Polyglucosamine L112; Placebo
Intervention type(s): Dietary Supplement; Combination Product
Intervention description(s): 750 mg of chitosan for tablet formulated with ascorbic acid and tartaric acids in the relative proportions of 91-6-3% with the addition of formulating excipients; excipients and gum arabic
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Obesity; Polyglucosamine; Body composition; Inflammation
Clinical Outcomes in Narcolepsy and Cataplexy: An Evaluation of Reboxetine Treatment (CONCERT)
Condition: Narcolepsy; Cataplexy Narcolepsy; Excessive Sleepiness
MeSH terms: Narcolepsy; Cataplexy; Sleepiness
Study type: Interventional
Phase: Phase 2

Summary: 
      CONCERT (Clinical Outcomes in Narcolepsy and Cataplexy: An Evaluation of Reboxetine
      Treatment) is a Phase 2, double-blind, randomized, placebo-controlled, crossover, multicenter
      trial of AXS-12 in patients with narcolepsy. Subjects meeting the entry criteria will be
      randomized in a 1:1 ratio either to placebo for three weeks followed by AXS-12 (up to 10 mg
      daily) for three weeks, or to AXS-12 (up to 10 mg daily) for three weeks followed by placebo
      for three weeks. Efficacy assessments will include the frequency of cataplexy attacks, and
      measures of other symptoms of narcolepsy.
    


Intervention name(s): AXS-12 (Reboxetine); Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Dosed orally, twice daily for up to 3 weeks; Dosed orally, twice daily for up to 3 weeks
Intervention MeSH terms: Reboxetine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: CONCERT; AXS-12; EDS; Cataplexy; Narcolepsy; Axsome; Reboxetine
Effect of Forward Head and Rounded Shoulder Posture on Hand Grip Strength in Asymptomatic Young Adults
Condition: Muscle Weakness
MeSH terms: Muscle Weakness
Study type: Observational

Summary: 
      -  see if there is significant difference between subjects with forward head rounded
           shoulder posture and subjects with normal posture in hand grip strength in asymptomatic
           young adults

        -  see if there is significant difference between subjects with rounded shoulder posture
           and subjects with normal posture in hand grip strength in asymptomatic young adults
    

Detailed description: 
      -  in forward head posture there is flexion in lower cervical vertebrae that causes tension
           on lower cervical nerve roots according to Harrison systemic review and these lower
           cervical nerve roots supply hand muscles

        -  also in rounded shoulder posture there is weakness in scapular stabilizers and
           retractors which affect proximal stability of the arm

        -  proximal stability is important for distal mobility

        -  so from this biomechanical point of veiw we conduct this study to see if forward head
           and rounded shoulder posture can affect hand grip strength in asymptomatic young adults.
    

Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        asymptomatic young adults students

          1. forward head rounded shoulder posture group

          2. rounded shoulder posture group

          3. normal posture group
      
Keywords: RS-FHRSP-grip strength
Evaluating the Effect of Mucinex® 1200 mg on Mucociliary and Cough Clearance From the Human Lung
Condition: Mucociliary Clearance
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this research study is to test the ability of Mucinex, an oral,
      over-the-counter, FDA approved expectorant) to stimulate the clearance of inhaled particles
      from the subject's lungs (called "mucociliary clearance"). The study will also monitor the
      metabolism of the drug by the subject's body.
    


Intervention name(s): Mucinex 1200mg; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Compared to Placebo; Compare to active Mucinex
Intervention MeSH terms: Phenylpropanolamine; Guaifenesin; Chlorpheniramine, phenylpropanolamine drug combination
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: healthy nonsmokers