Effects of Transcutaneous Acupoint Electrical Stimulation on Postoperative HRV and Hs-cTnT of Elderly With CHD
Condition: Coronary Artery Disease; Anesthesia
MeSH terms: Coronary Artery Disease
Study type: Interventional

Summary: 
      The aim of this study was to observe the effect of transcutaneous acupoint electrical
      stimulation (TAES) on postoperative heart rate variability and high-sensitive cardiac
      troponin T of elderly patients with coronary heart disease.
    

Detailed description: 
      General anesthesia can inhibit sympathetic nerve activity and attenuate stress response, but
      it also inhibits vagus nerve activity. The decrease of vagus nerve activity can cause
      cardiovascular complications, especially ventricular arrhythmia in patients with coronary
      heart disease. Some study have shown that electrical stimulation of transcutaneous acupoints
      can regulate the function of autonomic nervous system and enhance the activity of vagus nerve
      so as to protect myocardial tissue. But the effect on autonomic nervous function and
      myocardial injury markers in elderly patients with coronary heart disease was not reported.
      Heart rate variability (HRV) is a noninvasive and reliable index reflecting cardiac autonomic
      nervous function. High-sensitive cardiac troponin hs-cTnT is the best myocardial injury
      marker.

      The investigators plan to recruite 150 patients with coronary heart disease of both sexes,
      aged 65-80 yr, undergoing elective lumbar decompression and fusion internal fixation surgery.
      They will be randomly divided into 2 groups(n=75 each)using random number table : control
      group ( group C ) and TAES group (group T). Patients in group T receive TEAS (disperse-dense
      waves, frequency 4/20Hz) at the points of PC6 (Neiguan) and PC4 (Ximen) from 30 min before
      anesthesia induction to the end of surgery, the optimal intensity will be adjusted to
      maintain a slight twitching of the midfinger or ring finger (De-Qi response). Patients in
      group C receive electrode plate at the same acupoints without any electrical stimulation.
      Heart rate variability will be collected on 1 day before surgery, 1, 3 and 5d after surgery.
      3mL of venous blood will be collected before the induction of anesthesia, 1, 3 and 5d after
      surgery, the serum will be isolated for the measurement of serum concentration of
      high-sensitive troponin T (hs-cTnT)、CK、CRP.
    

Intervention name(s): transcutaneous acupoint electrical stimulation; sham transcutaneous acupoint electrical stimulation
Intervention type(s): Procedure; Procedure
Intervention description(s): Transcutaneous acupoint electrical stimulation(TAES) is a kind of noninvasive therapy similar to acupuncture and moxibustion. Its physiological effect is similar to that of electroacupuncture and hand acupuncture which is a Chinese traditonal therapy using acupuncture.; Sham transcutaneous acupoint electrical stimulation is the same procedure as transcutaneous acupoint electrical stimulation at points without electronic stimulation.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Anesthesia, General