bioihbjkbjnl/mcl2 huggingface dataset:
Comparison of Shoulder Stretches
Condition: Shoulder Impingement; Shoulder Pain; Adhesive Capsulitis; Rotator Cuff Tears; Posterior Capsule Tear; Glenohumeral Subluxation; Glenohumeral Dysplasia; Acromioclavicular; Sprain (Strain); Internal Rotation Contracture-shoulder; External Rotation Contracture-Shoulder; Flexion Contracture; Extension Contracture-Shoulder
MeSH terms: Shoulder Pain; Bursitis; Contracture; Shoulder Impingement Syndrome; Shoulder Dislocation; Rotator Cuff Injuries; Sprains and Strains
Study type: Interventional

Summary: 
      Various stretches are used to lengthen the posterior shoulder capsule. No study has reported
      the comparison of the pragmatic posterior capsular stretch and cross body stertch
    

Detailed description: 
      Background: Posterior capsular tightness (PCT) is frequently seen in shoulders in athletic
      population and shoulder disoders. PCT leads to variation in scapular and humeral kinematics.
      Two techniques considered in our study for regaining normal range of motion at shoulder joint
      and improving PCT, one is the pragmatic posterior capsular stretch (PPCS) & the other one is
      cross body stretch (CBS) Objective: The aim of our study id to compare the short
      term/intermediate term effect of PPCS and CBS on range of motion on shoulder joint in healthy
      individuals. And to evaluate the feedback of subjects regarding both the interventions.

      Methodology: Sixty a symtomatic shoulder of 30 subjects (15 males, 15 females) were recruited
      for this restricted randomised control trials. A simple random sampling technique was used.
      Subjects were screen through a functional movement screening tool of shoulder mobility. The
      change in hand behind neck and hand behind back will be measured through measuring tape.
      Shoulder ROM and functional movements for both the stretches will be campared. Particpants
      will be follwed for 4 weeks for the change in their shoulder range of motion.
    

Intervention name(s): pragmatic posterior capsular stretch; cross body stretch
Intervention type(s): Other; Other
Intervention description(s): pragmatic posterior stretch is used to increase the length of the posterior capsule; crossbody stretch performed by an individual
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: RCT
Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Effect of Honey and Dexamethason on Extraction Healing
Condition: Impacted Third Molar Tooth
MeSH terms: Tooth, Impacted
Study type: Interventional
Phase: Early Phase 1

Summary: 
      Natural honey and dexamethason will be given before impaction removal then postoperative
      complications will be evaluated
    

Detailed description: 
      Patient with impacted lower third molar will be selected to this study agording to agent
      applied preoperative. Group 1 will receive topical honey and Group 2 will receive IV
      dexamethason. After surgical removal of impacted tooth under local anesthesia postoperative
      pain mouth opening, and swelling will be evaluated
    

Intervention name(s): Normal saline; Dexamethasone; Honey; Dexamethasone and honey
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): Saline will be applied after surgery; Dexamethason will be given IV before surgery; Honey will be applied locally after surgery; Dexamethason will be given IV before surgery and then Honey will be applied locally after surgery
Intervention MeSH terms: Dexamethasone; Dexamethasone acetate; BB 1101
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Tele Nursing Application For Type 1 Diabetes Mellitus Adolescents
Condition: Telenursing; Adolescent; Type 1 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Interventional

Summary: 
      Studies have shown that tele-nursing practice is effective in children with Type 1 Diabetes
      Mellitus, but the number of studies conducted is very few. No study examining the concepts of
      metabolic control, self-efficacy, quality of life and anxiety together was found in the
      literature review. With this study, it is aimed that diabetes education given by tele-nursing
      has an effect on metabolic control, self-efficacy, quality of life and anxiety level of
      adolescents with type 1 diabetes, and that diabetic adolescents can easily obtain the
      information they need about nursing care when they cannot come to the clinic.
    


Intervention name(s): educational intervention
Intervention type(s): Behavioral
Intervention description(s): In the light of up-to-date information, "Type I Diabetes Education Guide" was created. With this guide, both face-to-face and tele-nursing training will be provided. Both working groups will receive training before starting research. The intervention group will continue their weekly training throughout the study.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized controlled and quasi-experimental research
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Telenursing; Type 1 Diabetes Mellitus; Metabolic Control; Self Efficacy; Quality of Life; Anxiety
Study of Pediatric Migraine: The Pediatric Migraine Registry
Condition: Migraine
MeSH terms: Migraine Disorders
Study type: Observational [Patient Registry]

Summary: 
      This is a multi-center registry that will prospectively collect regulatory compliant data
      from children and adolescents with migraine. This study will enroll approximately 200
      participants from approximately 20 sites and will examine migraine symptoms, therapeutics
      used, and biomarkers associated with migraine.
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Participants aged 4-17 years old (inclusive) diagnosed with migraine with or without aura
        will be eligible for participation in this study.
      
Biospecimen description: 
      Whole blood, buccal swab, urine, stool.
The Different Analgesic Potency of Volatile Anesthetics at Equi-MAC
Condition: Orthopedic Disorders
MeSH terms: Musculoskeletal Diseases
Study type: Interventional
Phase: Phase 3

Summary: 
      The aim of this clinical trial is to evaluate the difference of analgesic potency of
      sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth
      index.
    

Detailed description: 
      Volatile anesthetics vary in their relative hypnotic potencies. Recent studies demonstrated
      that equi-minimum alveolar concentration of various volatile anesthetics produced different
      EEG-derived indices such as bispectral index. However, there was no controlled study that
      demonstrates the difference of analgesic potency. The aim of this clinical trial is to
      evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum
      alveolar concentration using a surgical pleth index.
    

Intervention name(s): Sevoflurane; Desflurane
Intervention type(s): Drug; Drug
Intervention description(s): Anesthesia was maintained with sevoflurane in patients undergoing arthroscopic shoulder surgery under general anesthesia and interscalene brachial plexus block.; Anesthesia was maintained with desflurane in patients undergoing arthroscopic shoulder surgery under general anesthesia and interscalene brachial plexus block.
Other intervention name(s): SEVO; DES
Intervention MeSH terms: Sevoflurane; Desflurane
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Desaturation Validation of INVSENSOR00006
Condition: Healthy
Study type: Interventional

Summary: 
      This study is designed to compare the accuracy of a noninvasive measurement of oxygen
      saturation compared to reference values obtained by a laboratory blood gas analyzer. Arterial
      blood samples will be collected from healthy adult subjects while undergoing a desaturation
      procedure wherein the concentration of oxygen inhaled is slowly reduced until the subject's
      arterial oxygen concentration is approximately 70%. The subject will then be returned to
      inhaling room air.
    


Intervention name(s): INVSENSOR00006
Intervention type(s): Device
Intervention description(s): Noninvasive pulse oximeter sensor
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Other
A Study to Assess the Relative Bioavailability of Gilteritinib Following a Single Dose of Gilteritinib Mini-tablet Oral Suspension and Gilteritinib Mini-tablets Compared to a Single Dose of Gilteritinib Tablet in Healthy Subjects
Condition: Healthy Volunteer
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to assess the relative bioavailability as well as the safety and
      tolerability of single doses of gilteritinib mini-tablets oral suspension and gilteritinib
      mini tablets compared to gilteritinib tablets under fasting conditions in healthy male and
      female participants.
    

Detailed description: 
      Participants will be screened for up to 28 days prior to investigational product (IP)
      administration on day 1. Eligible participants will be admitted to the clinical unit on day
      -1 and will be residential for 10 days/9 nights.
    

Intervention name(s): gilteritinib; gilteritinib mini tablet
Intervention type(s): Drug; Drug
Intervention description(s): oral; oral
Other intervention name(s): ASP2215; ASP2215
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: gilteritinib; ASP2215; Healthy volunteer
Intracardiac Versus Transesophageal Echocardiography Versus Fluoroscopy Only Guidance for Combined Catheter Ablation for Atrial Fibrillation and Left Atrial Appendage Occlusion
Condition: Atrial Fibrillation
MeSH terms: Atrial Fibrillation
Study type: Interventional

Summary: 
      A total of 75 patients with atrial fibrillation were scheduled to receive left atrial
      appendage occlusion combined with radiofrequency ablation, which were divided into 3 groups.
      The operation was performed under the guidance of intracardiac echocardiography and
      transesophageal echocardiography and fluoroscope only respectively (allocation ratio 1:1:1).
      During the operation, the total amount of contrast medium injected, the fluoroscopy time and
      the time from femoral vein puncture to transseptal puncture to closure were recorded in all
      patients. All patients underwent transesophageal echocardiography before and 3 months after
      operation, and the results were explained by two experienced ultrasound doctors to measure
      the presence of left atrial thrombus, residual shunt and device-related thrombus. All
      patients were examined by transthoracic echocardiography 3 months after operation to evaluate
      new pericardial effusion, pericardial tamponade, instrument embolization / displacement and
      so on. The baseline clinical and surgical features and hospitalization outcomes of patients
      guided by ICE and TEE and fluoroscopy only were recorded and compared. Clinical endpoints
      include death, new pericardial effusion that does not require pericardiocentesis, tamponade
      with pericardiocentesis, instrument embolism / displacement, bleeding at the entry site,
      thromboembolic events (stroke / transient ischemic attack [TIA]). The purpose of this study
      was to evaluate the feasibility, safety and effectiveness of intracardiac echocardiographic
      (ICE)-guided and transesophageal echocardiographic (TEE)-guided and fluoroscopy only-guided
      left atrial appendage occlusion combined with radiofrequency ablation. The average follow-up
      time is 3 months.
    


Intervention name(s): LAAC combined with radiofrequency ablation
Intervention type(s): Procedure
Intervention description(s): Each patient received the same group of patients with simple radiofrequency ablation and LAAC
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Enteral Administration of Docosahexaenoic Acid to Prevent Retinopathy of Prematurity
Condition: Retinopathy of Prematurity
MeSH terms: Retinal Diseases; Retinopathy of Prematurity; Premature Birth
Study type: Interventional

Summary: 
      The purpose of this study is to evaluate whether docosahexaenoic acid given by enteral
      feeding prevent retinopathy of prematurity and/or diminish its severity in preterm infants.
    

Detailed description: 
      Preterm neonates who start receiving enteral feeding will receive the intervention with
      docosahexaenoic acid (DHA) since the first day and throughout 14 days, one dose per day.

      The opthalmic evaluation will be done after 4-5 weeks after birth and followed until 42-45
      corrected gestational age.
    

Intervention name(s): docosahexaenoic acid; sunflower oil
Intervention type(s): Dietary Supplement; Dietary Supplement
Intervention description(s): Docosahexaenoic acid is a dietary supplement derived from algae.; Sunflower similar to the excipient used in experimental group
Other intervention name(s): n-3 long chain polyunsaturated fatty acid
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Regarding the Study phase, the intervention was a nutraceutical, docosahexaenoic acid, derived from omega 3 fatty acid family.
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary purpose: Prevention
Keywords: DHA; Retinopathy of Prematurity
Femoral Triangle Block: Early Mobilization and Postoperative Analgesia After Total Knee Arthroplasty
Condition: Arthroplasty, Replacement, Knee; Anesthesia, Conduction; Pain, Postoperative; Ultrasonography, Interventional
MeSH terms: Pain, Postoperative
Study type: Interventional

Summary: 
      The objective of this trial is to compare the efficacy of three different nerve blocks as an
      analgesic option after total knee arthroplasty (TKA), based on muscle strength, mobilization
      and pain.

      The Adductor Canal Block has been proposed as an equally effective technique to the Femoral
      Nerve Block in terms of pain control after a TKA, with the benefit of preserving muscle
      function. We hypothesize that a block performed at the apex of the femoral triangle would
      best balance analgesia with quadriceps function.
    


Intervention name(s): Apex Femoral Triangle Block; Femoral Nerve Block; Adductor Canal Block
Intervention type(s): Procedure; Procedure; Procedure
Intervention description(s): Nerve block that aims the vastus medialis nerve, the saphenous nerve and the anterior femoral cutaneous nerve.; Regional anesthetic technique that blocks the sensory and motor information of the femoral nerve (and it's branches).; Interfascial block that targets mainly the saphenous nerve.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Preoperative Serum Albumin and Duration of Intraoperative Hypotension on Postoperative Acute Kidney Injury
Condition: Acute Kidney Injury
MeSH terms: Acute Kidney Injury; Hypotension; Wounds and Injuries
Study type: Observational

Summary: 
      Acute kidney injury is one of major adverse postoperative complications. research about
      postoperative acute kidney injury conclude that low preoperative albumin and intraoperative
      hypotension is associated to postoperative acute kidney injury. However, due to ethic issue
      and nonlinear realtionship between these factors and postoperative acute kidney injury, the
      exact threshold of these two risk factors were not be able to identified. The research tried
      to locate the exact threshold with implementation of penalized splines by generalized
      additive model.
    


Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        adult non-cardiac, non-obsteric, non- kidney elective surgery patients
Childhood Metabolic Markers of Adult Morbidity in Blacks
Condition: Healthy; Normal Weight; Overweight
MeSH terms: Overweight
Study type: Observational

Summary: 
      Blacks are at increased risk for obesity, type 2 diabetes mellitus and cardiovascular
      disease. A common pathogenetic link among these entities is insulin
      resistance/hyperinsulinemia.

      The specific aims of this project are: 1) to compare skeletal muscle lipid content (SMLC) in
      black vs white children by computed tomography (CT) scan of the mid-thigh, and assess the
      relationship to in vivo insulin sensitivity; 2) to test the hypothesis that free fatty acid
      (FFA) - induced insulin resistance is associated with larger increases in intramyocellular
      lipid (IMCL) in black vs white adolescents; 3) to examine if β-cell insulin secretion in
      prepubertal black children is more sensitive to the stimulatory effect of FFA than in whites;
      and 4) to test if the β-cell in black obese adolescents is more susceptible to the lipotoxic
      effect of FFA compared with whites. The methods to be used are: the well- established CT
      method as well as Magnetic Resonance Spectroscopy (1H-MRS) to assess SMLC and IMCL;
      intralipid infusion to elevate circulating FFA levels; the hyperinsulinemic-euglycemic clamp
      with stable isotopes and indirect calorimetry to measure insulin sensitivity and substrate
      turnover; the hyperglycemic clamp to assess insulin secretion; DEXA and whole body MRI for
      body composition assessments.
    


Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Healthy black and white volunteers who are 8 to 17 years of age
MGTA-456 in Patients With Inherited Metabolic Disorders Undergoing Hematopoietic Stem Cell Transplantation (HSCT)
Condition: Inherited Metabolic Disorders (IMD)
MeSH terms: Metabolic Diseases
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is designed to assess the safety and efficacy of using MGTA-456 in patients with
      Inherited Metabolic Disorders (IMD) undergoing stem cell transplantation.
    

Detailed description: 
      This phase 2 study is designed to evaluate the safety and efficacy of MGTA-456 in patients
      with IMD after receiving myeloablative conditioning and HSCT. MGTA-456 is an expanded CD34+
      cell therapy product candidate given to induce rapid and sustained hematopoietic engraftment.
      In patients with selected IMDs, transplant is expected to replace defective or missing
      protein and preserve neurodevelopment. Since MGTA-456 offers increased numbers of HSCs over
      standard umbilical cord blood, it is expected to reduce the risks of prolonged neutropenia
      and thrombocytopenia and graft failure, and potentially transplant-related mortality (TRM).
      Patients with Hurler syndrome (also referred to as mucopolysaccharidosis-1H (MPS-1H)),
      cerebral adrenoleukodystrophy (cALD), metachromatic leukodystrophy (MLD) or globoid cell
      leukodystrophy (GLD) (also referred to as Krabbe disease) are eligible for this study.
    

Intervention name(s): MGTA-456
Intervention type(s): Drug
Intervention description(s): Hematopoietic stem cell transplantation will be done with the cell therapy product MGTA-456.
Other intervention name(s): HSC835
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: inherited metabolic disorders; cerebral adrenoleukodystrophy; Hurler syndrome; globoid cell leukodystrophy; Krabbe disease; metachromatic leukodystrophy; hematopoietic stem cells; hematopoietic stem cell transplant; umbilical cord blood; umbilical cord blood transplant; MGTA-456; myeloablative conditioning regimen; bone marrow transplant; mucopolysaccharidosis-1H
A Study to Investigate the Effect of Mirabegron (YM178) on Subjects With Mild or Moderate Hepatic Impairment Compared to Healthy Subjects
Condition: Pharmacokinetics; Healthy Subjects; Mild and Moderate Hepatic Impairment
MeSH terms: Liver Diseases
Study type: Interventional
Phase: Phase 1

Summary: 
      The study aims to investigate and compare the effect of Mirabegron (YM178) on subjects with
      mild and moderate hepatic impairment compared to healthy subjects.
    

Detailed description: 
      Healthy subjects and subjects with mild and moderate hepatic impairment are admitted on Day
      1. Subjects receive a single oral dose of Mirabegron in the morning of Day 1 and will remain
      in the unit till Day 5 with outpatient visits on Days 6 and 7 for healthy subjects and Days
      6, 7, 9 and 11 for subjects with hepatic impairment. Blood sampling for PK assessment will be
      up to 144 hrs post dose for healthy subjects and up to 240 hrs post dose for subjects with
      hepatic impairment. An additional blood sample was obtained for all subjects 4 hrs post dose
      for protein binding.
    

Intervention name(s): mirabegron
Intervention type(s): Drug
Intervention description(s): oral
Other intervention name(s): YM178
Intervention MeSH terms: Mirabegron
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Pharmacokinetics; mirabegron; hepatic impairment; Phase 1
Efficacy of XP20B Following Bunionectomy Surgery
Condition: Acute Pain
MeSH terms: Acute Pain
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of this study is to determine if XP20B is an effective treatment for the relief
      of pain following bunionectomy surgery.
    


Intervention name(s): XP20B; Placebo
Intervention type(s): Drug; Drug
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: pain
Importance of Hollow or Solid Centralizer for Polished, Collarless and Tapered Stems in Total Hip Arthroplasty
Condition: Total Hip Arthroplasty
Study type: Interventional

Summary: 
      The study aims at comparing the effect of hollow or solid centralizer designs on the long
      time fixation behaviour of hip prosthesis stems that are polished, tapered and collarless. In
      a prospective, controlled and randomized study comprising two groups of 30 patients/hips
      each, the patients will be followed up by RadioStereometric Analysis (RSA) for ten years. In
      completion general health questionnaires as well as hip specific scoring instruments will be
      used to evaluate patient satisfaction and outcome.The hypothesis of the study is that the
      different centralizers will result in different migration patterns of the stems, which might
      affect the risk for late aseptic loosening.
    


Intervention name(s): Hollow Centralizer; Solid Centralizer; MS-30 femoral stem
Intervention type(s): Procedure; Procedure; Device
Intervention description(s): The stem used (MS30)was originally designed with a solid centralizer but has been redesigned to be used with a hollow centralizer. The patients are randomized to either solid or hollow centralizer; The stem used (MS30)was originally designed with a solid centralizer but has been redesigned to be used with a hollow centralizer. The patients are randomized to either solid or hollow centralizer; This is the stem used in the study.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Radiostereometry; Total Hip Arthroplasty; Stem design