Honey and a Mixture of Honey, Beeswax and Olive Oil-propolis Extract in Treatment of Chemotherapy-induced Oral Mucositis
Condition: Oral Mucositis
MeSH terms: Mucositis; Stomatitis
Study type: Observational

Summary: 
      Although, oral mucositis has been studied for many years, no available treatment has been
      shown to be effective in preventing or treating mucositis. Based on the observations that
      honey and other products of honeybees have anti-inflammatory, anti-oxidant, anti-microbial
      and wound healing effects, the present study aims at evaluation of the effect of topical
      application of honey and a mixture of honey, beeswax and olive oil-propolis extract, as
      natural products, in treatment of chemotherapy-induced oral mucositis in children with acute
      lymphoblastic leukemia (ALL). This is a randomised controlled clinical trial in which
      eligible patients were randomly assigned into three equal treatment groups. Group 1 received
      15 gm honey applied topically to the affected oral mucosa three times daily. Group 2 received
      5 gm of a mixture of honey, olive oil-propolis extract and bees wax (HOPE) applied topically
      to the oral mucosa three times daily. Group 3 served as control and received a 7.5%
      benzocaine gel applied to the areas of ulcers three times daily.
    

Detailed description: 
      All patients with ALL during the consolidation phase of treatment, and with
      chemotherapy-related oral mucositis grades 2 and 3 were candidates for this trial.Exclusion
      criteria included the presence of any of the following: (1) coexisting diabetes mellitus, (2)
      administration of antiviral, antifungal therapy and / or any other treatment for oral
      mucositis before enrollment in the study, (3) presence of neutropenia (absolute neutrophilic
      count [ANC] ≤ 1500/mm3), (4) presence of advanced or severe periodontitis (patients with
      periodontal pockets of 6 mm or more. The primary outcome measure was the "recovery time",
      defined as the number of days from initiation of treatment to when complete healing of all
      ulcers occurred.
    

Intervention name(s): honey, hope,mucositis
Intervention type(s): Other
Intervention description(s): Eligible patients were randomly allocated by a computer-generated list of random numbers to be assigned into one of three treatment groups; Group (1) received an empirical dose of 15 gm honey applied topically to the affected oral mucosa three times daily until healing or for 10 days, which ever comes first. Group (2) received an empirical dose of 5 gm of a 4:2:1 mixture of honey, olive oil-propolis extract and beeswax (HOPE) applied topically to the oral mucosa three times daily until healing or for 10 days, which ever comes first. Group (3) served as controls and received benzocaine 7.5% gel applied topically to areas of ulcers three times daily.
Other intervention name(s): honey,propolis,olive oil, mucositis
Intervention MeSH terms: Propolis
Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Eligible patients were randomly allocated by a computer-generated list of random numbers to
        be assigned into one of three treatment groups; 30 patients each. Group (1) received an
        empirical dose of 15 gm honey applied topically to the affected oral mucosa three times
        daily until healing or for 10 days, which ever comes first. Group (2) received an empirical
        dose of 5 gm of a 4:2:1 mixture of honey, olive oil-propolis extract and beeswax (HOPE)
        applied topically to the oral mucosa three times daily until healing or for 10 days, which
        ever comes first. Group (3) served as controls and received benzocaine 7.5% gel applied
        topically to areas of ulcers three times daily.