bioihbjkbjnl/mcl2 huggingface dataset:
Educational Intervention to Increase Physician Satisfaction and Effectiveness With a New Electronic Health Record
Condition: Attitude of Health Personnel
Study type: Interventional

Summary: 
      This study was intended to test the effects of adding a one-on-one educational intervention
      taught by a physician to a physician during their clinical work to improve their acceptance
      and satisfaction with a new inpatient electronic health record and ordering system.
    

Detailed description: 
      This study was a randomized, parallel , non- blinded controlled trial of real-time, focused
      educational interventions in an intervention arm compared with usual training and support in
      the control arm. Improvement in performance, defined as the time between opening and closing
      a progress note, and number of notes completed after shift , were the primary outcomes.
      Physician satisfaction was a secondary outcome. Participants from one 550-bed Academic
      Independent Medical Center were invited to participate if they were full-time hospitalists or
      residents in internal medicine with no prior experience with the EPIC electronic health
      record.
    

Intervention name(s): One-on-one physician training; Usual training
Intervention type(s): Other; Other
Intervention description(s): Physicians in the experimental arm were visited by a instructing physician at a computer while performing clinical duties who had observed others to identify best practices. Instructors watched subjects' work, looking for a specific tip that could be applied to the current work, then demonstrated the tip, and answered any questions the subject had about using or applying this new technique .; Usual training included online e-modules, 12 hours of classroom time, practice in the EPIC Playground, user acceptability training classes,non-physician technical support on all of the floors, and a physician-only help line.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Physicians; Electronic Health Record; Education
Lactate Imaging as a Tumour Biomarker
Condition: Cancer
Study type: Observational

Summary: 
      This project is designed to investigate whether measurements of lactate in tumours, made
      using a magnetic resonance technique similar to MRI, is an effective non-invasive method to
      detect whether some new targeted drugs are having their desired effect.

      The study hypothesis is that by using magnetic resonance spectroscopy techniques, we will be
      able to observe changes in tumour lactate levels in vivo, in response to treatment.
    


Intervention name(s): Magnetic Resonance Imaging (MRI)
Intervention type(s): Device
Intervention description(s): Magnetic Resonance Spectroscopy
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Primary care clinic
      
Keywords: Magnetic Resonance Spectroscopy; Lactate
Functional and Value-Added Dairy Products and Blood Glucose Control
Condition: Blood Glucose, High; Metabolic Disease; Overweight and Obesity
MeSH terms: Overweight; Metabolic Diseases
Study type: Interventional

Summary: 
      Milk proteins possess multiple biological activities including their effect on blood glucose
      control, satiety and energy intake. The design of functional food products with added milk
      protein fractions has many challenges related to their inferior sensory properties. Chocolate
      milk presents the universal vehicle for added milk protein fractions that might partially
      mask their sensory characteristics. However, commercially produced chocolate milk has a
      significant amount of added sugar. This project will investigate the properties of a
      value-added dairy product (chocolate milk with reduced sugar content) enriched with
      individual milk protein fractions on characteristics of blood glucose control, satiety and
      energy intake in young healthy adults.
    


Intervention name(s): Food
Intervention type(s): Other
Intervention description(s): Dairy products with reduced sugar content
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Sugar intake; Sweeteners; Milk Proteins; Diabetes; Obesity; Sweetened food products; Chocolate milk; Blood glucose; Insulin; Satiety; Food Intake; Casein; Whey protein
Effect of Soy Phytoestrogens and Acupuncture on Bone Mineral Density in Female Athlete Triad at Adolescence Age
Condition: Osteoporosis, Osteopenia
MeSH terms: Osteoporosis; Bone Diseases, Metabolic; Female Athlete Triad Syndrome
Study type: Interventional

Summary: 
      The aim of this study to determine the effect of soy phytoestrogens and acupuncture on
      osteoporosis in female athlete triad at adolescence age. It is hypothesized that:

      - There will be no statistical significant difference between the effects of soy
      phytoestrogens and acupuncture on osteoporosis in female athlete triad at adolescence age.
      RESEARCH QUESTION: Do soy phytoestrogens and acupuncture have an effect on bone mineral
      density in female athlete triad at adolescence age?
    

Detailed description: 
      Many female athletes don't depend only on physical training and exercising to obtain the
      ideal slim and thin body. So that they follow harmful unhealthy diet to achieve the ideal
      body shape they are seeking. These types of diet can lead to malnutrition, menstrual
      disturbances, and bone loss, and these three components form a triad called female athlete
      triad. A limited number of studies have examined the effect of acupuncture and soy products
      on irregularities related to female athletes so the aim of this study is to investigate the
      effect of both acupuncture in line with diet modification using soy products on osteopenia in
      female athlete triad. Study Design: A prospective, randomized, single-blind, pre-post-test,
      controlled trial.

      Sixty female athletes with ages ranged from 14 to 18 years, playing gymnastics and all
      diagnosed and referred with female athlete triad resulting in decreased bone mineral density
      and osteoporosis. All participants will be treated with soy products and acupuncture and will
      be closely followed for six months. DEXA will be used to assess bone mineral density before
      and after the treatment program.
    

Intervention name(s): Acupuncture needles; Soy phytoestrogens
Intervention type(s): Device; Dietary Supplement
Intervention description(s): Standard acupuncture needle which is 3 cm long with diameter o.3 mm; 100 millilitre of soy milk every day or 100 gram of cooked soy beans per day.
Intervention MeSH terms: Phytoestrogens
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Keywords: female athlete triad
Prevention and Treatment of Hypertension Study (PATHS)
Condition: Cardiovascular Diseases; Heart Diseases; Hypertension; Vascular Diseases
MeSH terms: Hypertension; Cardiovascular Diseases; Heart Diseases; Vascular Diseases
Study type: Interventional
Phase: Phase 3

Summary: 
      To evaluate the long-term effect of reduction of alcohol intake on blood pressure in moderate
      but non-dependent drinkers with mild hypertension or high normal blood pressure.
    

Detailed description: 
      BACKGROUND:

      Numerous observational epidemiologic studies have established ethanol intake as one of the
      most important determinants of blood pressure levels. However, data from intervention studies
      were very limited.

      The study was an inter-agency agreement involving the Veterans Administration and the
      National Institute on Alcohol Abuse and Alcoholism (NIAAA). Protocol development occurred
      between October 1988 and June 1989. The protocol was approved by the VA Cooperative Studies
      Evaluation Committee in July 1989 and reviewed by a separate Data and Safety Monitoring Board
      in September 1989.

      DESIGN NARRATIVE:

      Subjects were randomized to intervention or control groups. Intervention aimed to reduce
      alcohol intake to no more than 14 drinks per week and 50 percent or less of each
      participant's baseline level. The intervention technique consisted of a cognitive-behavioral
      program, the intensive phase of which consisted of six counseling sessions over three months.
      Echocardiograms were obtained at baseline and six months after randomization. Biochemical
      markers were used to validate changes in alcohol consumption. The trial included an
      eighteen-month feasibility phase with six-month follow-up and a 36-month main trial with two
      years of follow-up. Recruitment for the full-scale trial ended in June 1993. Final study
      visits were conducted in September and October 1994.

      The study completion date listed in this record was obtained from the "End Date" entered in
      the Query View Report System (QVR).
    

Intervention name(s): behavior therapy
Intervention type(s): Behavioral
Allocation: Randomized
Primary purpose: Prevention
Immunogenicity and Safety of Concomitant and Non-Concomitant Administration of RotaTeq® (V260) and Inactivated Poliomyelitis Vaccine in Healthy Chinese Infants (V260-074)
Condition: Prevention of Rotavirus Gastroenteritis in Infants and Children Caused by Serotypes G1, G2, G3, G4, and G9
MeSH terms: Poliomyelitis; Gastroenteritis
Study type: Interventional
Phase: Phase 3

Summary: 
      This study will evaluate the immunogenicity and safety of concomitant administration of
      RotaTeq® (V260) and inactivated poliomyelitis vaccine (IPV) in Chinese infants. Its primary
      objective is to demonstrate that the immunogenicity of IPV in the concomitant-use group is
      non-inferior to the immunogenicity of IPV in the staggered-use group. The hypothesis to be
      tested is: The seroconversion percentage at 1 month post dose 3 for poliovirus types 1, 2,
      and 3 in the concomitant-use group is non-inferior to those of the staggered-use group.
    


Intervention name(s): RotaTeq (V260); IPV
Intervention type(s): Biological; Biological
Intervention description(s): Live, pentavalent rotavirus vaccine administered as a 2 mL-dose oral solution; 0.5 mL dose IPV (Sabin strain based), administered via IM injection
Other intervention name(s): RotaTeq; V260
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Prospective Radiologic Evaluation of Changes Following Fat Grafting
Condition: Breast Cancer
MeSH terms: Breast Neoplasms
Study type: Observational

Summary: 
      Breast implants are currently used for cosmetic breast augmentation and in breast
      reconstruction following mastectomy for breast cancer. Fat grafting is a technique where fat
      is injected around the periphery of a breast implant to camouflage the transition between
      implant and the body. The investigators propose to show mammography images of women who have
      had breast implants with fat grafting to informed and blinded radiologists and evaluate their
      readings of the images.

      Hypothesis: with mammographic screening, radiologists will be able to distinguish between
      findings associated with fat grafting and those which are suspicious for breast cancer.
    


Observational model: Case-Only
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        We will select patients from Clinique Spontini Paris France and from patients at the
        University of Minnesota USA who have undergone placement of silicone breast implants with
        fat grafting.
Haemodynamic Effects of Oxytocin and Carbetocin
Condition: Pregnancy Related; Cesarean Section; Complications; Adverse Reaction to Oxytocic Agents
Study type: Observational

Summary: 
      The purpose of this study is to evaluate the immediate effects of carbetocin and oxytocin on
      maternal hemodynamic parameters (heart rate and blood pressure) in a non-invasive setup
      (TaskeForce®-Monitor) during primary Caesarean section.
    

Detailed description: 
      As there is a trend toward childbearing in later life, pre-existing maternal cardiovascular
      problems may become more frequent during pregnancy and at delivery. In addition the
      increasing number of women with congenital or acquired cardiac diseases may not tolerate the
      induced haemodynamic changes as well as healthy patients. Therefore uterotonic drugs must be
      safe for the cardiovascular system.

      Currently oxytocin is used as a common uterotonic agent in obstetrics. The use of this drug
      in uterotonic reasons can cause serious haemodynamic side effects which has been shown by
      several investigators.

      Preliminary clinical observations of maternal heart rate and blood pressure suggest that that
      the use of carbetocin causes less hemodynamic changes than oxytocin.

      Primary objective(s):

      To evaluate the effect of carbetocin on maternal hemodynamic parameters (heart rate, blood
      pressure, systemic vascular resistance, cardiac output, stroke volume, heart rate
      variability, and blood pressure variability) in a non-invasive setup (TaskeForce®-Monitor)
      during primary Caesarean section.

      To compare the haemodynamic changes of carbetocin versus oxytocin.

      Secondary objective(s) To evaluate the need of additional drugs and methods to control
      uterine tone.
    

Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        Women undergoing elective caesarean section after regional anesthesia at an University
        hospital providing intrapartum care.
      
Keywords: Caesarean section; Cardiovascular effects; Postpartum hemorrhage; Carbetocin; Oxytocin
Metoclopramide for Migraine: A Dose Finding Study
Condition: Migraine
MeSH terms: Migraine Disorders
Study type: Interventional
Phase: Phase 3

Summary: 
      Metoclopramide is an effective intravenous treatment for acute migraine attacks, but we do
      not know the best dose to administer. This study compares three different doses of
      metoclorpamide.
    

Detailed description: 
      Patients with acute migraine attacks are eligible for enrollment if they present to the
      emergency department of Montefiore Medical Center. Pain scores are assessed at baseline and
      every 30 minutes for two hours, and then again by telephone 48 hours after discharge
    

Intervention name(s): metoclopramide; metoclopramide; metoclopramide; Diphenhydramine 25mg
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): metoclopramide 20 mg; metoclopramide 40 mg; metoclopramide 10 mg; Diphenhydramine 25mg, administered as an intravenous drip over 20 minutes
Intervention MeSH terms: Diphenhydramine; Promethazine; Metoclopramide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Effect of Probiotics on Health-related Quality of Life in College Students With Upper Respiratory Infections
Condition: Upper Respiratory Infection
MeSH terms: Infections; Communicable Diseases; Respiratory Tract Infections
Study type: Interventional

Summary: 
      The main purpose of the study is to find out if probiotics (healthy bacteria found in yogurt)
      can improve the health-related quality of life (HRQL) during upper respiratory infections
      (like the common cold) in college students living in residence hall on-campus at Framingham
      State University (Framingham, MA) who are randomized to receive a probiotic or placebo candy
      daily for 12 weeks. HRQL is a subjective measure, defined as the aspects of quality of life
      (i.e., one's satisfaction with their life) that related specifically to a person's health
      (for example, ability to carry out normal daily activities). The investigators hypothesize
      that HRQL during URIs will be significantly higher in the probiotic groups compared to the
      placebo group. The proposed study will also seek to address the following secondary
      objectives: missed school and work days due to a upper respiratory infection.
    


Intervention name(s): Probiotics; placebo
Intervention type(s): Dietary Supplement; Dietary Supplement
Other intervention name(s): Lactobacillus rhamnosus LGG® (LGG®); Bifidobacterium animalis ssp lactis BB-12® (BB-12®)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Keywords: Health related quality of life; Functional Status
Study to Determine the Maximum Tolerated Dose, Safety and Effectiveness of Pomalidomide for Patients With Sickle Cell Disease
Condition: Anemia, Sickle Cell
MeSH terms: Anemia, Sickle Cell
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of the study is to determine the maximum tolerated dose, safety and effect on
      induction of fetal hemoglobin of pomalidomide in patients with Sickle Cell Disease.
    


Intervention name(s): pomalidomide
Intervention type(s): Drug
Intervention description(s): Pomalidomide orally for 84 days daily in doses ranging from 0.5 mg to 4.0 mg
Other intervention name(s): CC-4047
Intervention MeSH terms: Pomalidomide
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Pomalidomide; Sickle Cell Disease; Fetal Hemoglobin
Study to Evaluate the Safety and Tolerability of GBT440 Administered to Subjects With IPF
Condition: Idiopathic Pulmonary Fibrosis; Hypoxemia
MeSH terms: Pulmonary Fibrosis; Idiopathic Pulmonary Fibrosis; Fibrosis; Hypoxia
Study type: Interventional
Phase: Phase 2

Summary: 
      This study is a randomized, double-blind, placebo-controlled trial in which eligible IPF
      subjects will be randomized to receive GBT440 or Placebo orally daily.
    


Intervention name(s): GBT440; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Capsules which contain GBT440 drug substance in Swedish orange; Placebo capsules
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Supportive Care
Study Evaluating Single Doses of BLI-489 in Healthy Subjects
Condition: Healthy Subjects
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to evaluate the safety, and tolerability of single doses of
      BLI-489 administered intravenously in healthy subjects, and also how the drug is absorbed and
      eliminated.
    


Intervention name(s): BLI-489; Placebo
Intervention type(s): Drug; Drug
Intervention MeSH terms: BLI-489
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double
Primary purpose: Treatment
Preliminary Testing of the Vitaliti CVSM Wearable, Vitaliti Spirotoscope, and Vitaliti IVD Station
Condition: Urinary Tract Infection; Diabetes Mellitus; Atrial Fibrillation; OSA; COPD; Pneumonia; Acute Otitis Media; Leukocytosis; Iron Deficient Anemia; Hypertension; Healthy Volunteers
MeSH terms: Urinary Tract Infections; Otitis Media; Atrial Fibrillation; Leukocytosis
Study type: Observational

Summary: 
      The study objective is to satisfy the testing requirements for the Qualcomm Tricorder XPRIZE
      Competition. This requires an oversight model using the Vitaliti CVSM Wearable, Vitaliti
      Spirotoscope, and Vitaliti IVD Station to continuously monitor the patient's five core vital
      signs and to detect the health conditions required by the competition.
    


Intervention name(s): Vitaliti
Intervention type(s): Device
Observational model: Other
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        Adult subjects with urinary tract infection, diabetes mellitus, atrial fibrillation, sleep
        apnea, COPD, pneumonia, acute otitis media, leukocytosis, anemia, or hypertension will be
        recruited to participate in this observational study from Oakville-Trafalgar Memorial
        Hospital.
Volumetric Three-dimensional Analysis of the Pediatric Upper Airway Shape Using Computed Tomography Imaging.
Condition: Airway Management
Study type: Observational

Summary: 
      CT and MRI based measurements of the pediatric airway has changed the age-old cone shape
      concept of the pediatric airway and define airway shape as elliptical structure. The cone
      shape was based on the cadaveric measurements done by Bayeux in 1897 and described later by
      Eckenhoff in 1951.

      The present study is based on three-dimensional CT images of the airway column replicating
      the cylinders used by Bayeux for his cadaveric measurements. The purpose of this study was to
      determine the cone shape of the pediatric airway.
    

Detailed description: 
      This is a retrospective review of three-dimensional CT air column images of 60 children aged
      1 month to 8 years undergoing radiological evaluation unrelated to airways symptomatology.
      The CT scans will be evaluated in children either sleeping naturally or sedated throughout
      the study period. Volumetric analysis of the air-column was done at the level of cricoid,
      subglottis and trachea

      Exclusion Criteria:

      Patients with a tracheostomy or endotracheal tube in place, tracheo-esophageal fistula,
      pulmonary collapse or atelectasis, mediastinal mass, diaphragmatic hernia, extrapulmonary and
      intrathoracic mass, preterm infants, and patients with genetic syndromes and primary lung
      diseases.

      Patients with poor image quality were also excluded from the study.
    

Intervention name(s): CT Scan
Intervention type(s): Radiation
Intervention description(s): CT imaging
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        Children aged 1 month to 8 years undergoing radiological evaluation (CT Imaging) unrelated
        to airways symptomatology
      
Keywords: Pediatric Airway, Three-dimensional Imaging, CT Scan