Effectiveness of Artificial Balneotherapy, Phototherapy and Artificial Balneophototherapy in the Treatment of Psoriasis
Condition: Psoriasis
MeSH terms: Psoriasis
Study type: Interventional

Summary: 
      The purpose of this study is to compare the effectiveness of artificial balneotherapy (AB),
      phototherapy (PT) and artificial balneophototherapy (BPT) in the treatment of plaque
      psoriasis, evaluating the plaque area, alteration of skin pigmentation, Psoriasis Area and
      Severity Index (PASI) score determination and quality-of-life assessment by Short Form 36
      Health Survey (SF-36) and Psoriasis Disability Index (PDI) scores during the month of
      treatment. Methods: Experimental study, prospective, randomized, single-blind. 14 subjects
      participated from the city of Talca, Chile medically diagnosed with psoriasis, more than one
      plaque in the skin without topical treatment voluntarily. All subjects completed the study
      that consisted of 12 sessions.
    

Detailed description: 
      On the selected subjects, it was also performed the evaluation of Minimal Erythema Dose (MED)
      in order to determine an acceptable dose of UV-B light for the type of skin of each patient.
      Thus, the evaluations were performed according to psoriasis type, area, color and plaques
      severity. The formula used for the calculation was:

      MED = 2×t(s)×0,75 t: minimum time for erythema occurrence.

      Each psoriatic plaque was submitted to three therapeutic sessions per week, during 4 weeks,
      for a total of 12 sessions.

      For the application of AB, the AB group plaques were immersed during 15 minutes in a 35 or 75
      l hydrotherapy whirlpool (TB-T45 model and TB-T90 model respectively, Enraf Nonius Company
      SA, Spain) filled with a solution of warm water (32 °C) and natural sea salt (250 g/L),
      following the similar protocol of others authors always ensuring that the plaques not
      receiving this treatment were kept isolated with flexible and insulating adhesive patches
      (Nexcare® Factory 3M, Chile).

      For the implementation of PT, the PT group plaques that would not receive radiation were
      covered with thick cloth towels, while the healthy skin surrounding the treated plaques were
      coated with liquid petroleum jelly. Both patients and attendant were protected with special
      lenses with filter against UV light (Oakley Jupiter, USA). UV-B radiation was applied with
      the UV Endolamp 474 device (Enraf Nonius Company SA, Spain), 60 cm away from the plaque and
      in a perpendicular position. In session 1, the MED was calculated for each subject and used
      as the time of UV-B exposure. On each further session, the exposure time was increased by
      25%, until the limit of 5 minutes.

      The BPT group plaques received both AB and PT treatments, on the same conditions described
      above, consecutively.

      The C group plaques did not receive any treatment.

      Data Collection The plaques were photographed at a distance of 20 cm with a 12 pixel Lumix
      digital camera (Panasonic, USA). For area quantification, the photographs were taken before
      session 1 and a day after session 6 and 12, and were analyzed with ImageJ software (version
      1.46j; National Institute of Health, MD, USA). For color evaluation, the photographs taken
      before session 1 and after session 12 were analyzed with the Average color seeker software
      (Version 0.41; IDimager Systems Inc., Scotts Valley, CA, USA), which uses the Red-Green-Blue
      (RGB) coordinates system that reports the information about the red color channel, associated
      to erythema occurrence, in arbitrary units. Therefore, greater red color measurements for
      skin pigmentation may indicate increased erythema.

      The psoriatic plaque severity was assessed before session 1 and one day after session 12
      through PASI, which considers erythema, induration and plaque scaling, being 72 points the
      maximum score.

      Quality of life assessment was performed using the SF-36 TM v2 health questionnaire,
      validated for the Chilean population10, and with the psoriasis disability index (PDI), both
      performed before session 1 and one day after session 12.
    

Intervention name(s): phototherapy; balneotherapy; balneophototherapy
Intervention type(s): Radiation; Procedure; Procedure
Intervention description(s): Twelve sessions of phototherapy (UV-B) according to individual initial evaluation of Minimal Erythema Dose (MED).; Twelve sessions of 15 minutes of balneotherapy (warm water, 32 °C and natural sea salt, 250 g/L).; Twelve sessions of both balneotherapy and phototherapy treatments.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Psoriasis; balneotherapy; phototherapy; balneophototherapy