bioihbjkbjnl/mcl2 huggingface dataset:
Examining the Impacts of Fidget Technology on Attention in Children With ADHD
Condition: ADHD
MeSH terms: Attention Deficit Disorder with Hyperactivity
Study type: Interventional

Summary: 
      Purpose: The purpose of this study is to investigate the usage of fidget technology and its
      effects on attention, working memory, and comprehension in children ages 6-13 with Attention
      Deficit Hyperactivity Disorder (ADHD). This study aims to examine the implications of fidget
      usage 2 different measures of attention; attentional control (working memory domain) and
      comprehension (recall, encoding, and recognition).

      Participants: 6-13 year-old clients at 3-C Family Services, a private mental health clinic in
      Cary, NC, with a diagnosis of ADHD (Inattentive, Hyperactive, or combined types). Exclusion
      criteria: participants with an Intelligence Quotient (IQ) below 70 as estimated by referring
      3-C clinical staff, or any history of psychosis.

      Procedures (methods): This research will use a demographic and background collecting survey
      to gather relevant data about each participant. Parents will be asked to fill out a baseline
      ADHD Rating Scale-IV: Home Version (ADHD-RS), to account for their child's symptoms of ADHD
      over the past 6 months. Participants will be randomly assigned to one of 2 conditions, an
      experimental group where participants select a fidget, and a control group where participants
      are not provided a fidget. Fidget options will include a fidget spinner, pop-it, stress ball,
      and fidget cube as not all children would benefit from the same type of fidget equally.
      Participants in the experimental group will then be allowed to practice with and familiarize
      themselves with the fidget for 1 minute to decrease the attentional drain that the fidget may
      pose in its initial state.

      After random assignment to either control or experimental group, participants in each group
      will then complete the same 2-back version of the N-back Attention Control Task
      (cognitivefun.net), and a video comprehension multiple choice test. After 3 minutes N-back
      scores will be recorded including visual correct ratio and visual response time scores. The
      video comprehension item is adapted from Lee and List, 2019. The video is a Ted Talk titled
      "The Survival of the Sea Turtle" ( https://www.youtube.com/watch?v=t-KmQ6pGxg4). Items in the
      multiple choice test will be aggregated to a score of percent correctness for each
      participant. Participants may request to have questions read to them by the research
      assistant present.
    


Intervention name(s): Fidget Device; Control group
Intervention type(s): Other; Other
Intervention description(s): Fidget spinner, stress ball, pop-it, or fidget cube; No intervention
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Fidget technology; ADHD; Children; Developmental Psychology
Evaluation of Vaginal Self-sampling Diagnostic Performances to Identify Genital Infections
Condition: Genital Infection; Asymptomatic Infections
MeSH terms: Infections; Communicable Diseases; Asymptomatic Infections
Study type: Interventional

Summary: 
      Screening for genital infection (GI), sexually transmitted infection (STI) and asymptomatic
      carriage of group B streptococcus (GBS) in pregnant women is a common reason for medical
      appointments. Conventional testing is performed by using vaginal and/or cervical classic
      sampling (VCS). Vaginal self-sampling (VSS) has progressively emerged as an alternative to
      VCS for STI agent screening. The use of vaginal self-sampling (VSS) could facilitate
      follow-ups and potentially help in the prevention of gynaecological disorders.
    


Intervention name(s): Vaginal self-sampling
Intervention type(s): Procedure
Intervention description(s): The objective is to determine the non-inferiority of vaginal self-sampling compared with vaginal/cervical classical sampling, and evaluate the possibility of using it in all clinical situations indicating the prescription of such a procedure to screen for genital infections (GIs), sexually transmitted infections (STIs) and group B streptococcus (GBS) asymptomatic carriage in pregnant women.
Intervention model: Single Group Assignment
Intervention model description: Participants were screenned for genital infections
performing vaginal and/or cervical classical-sampling (VCS)
performing vaginal self-sampling (VSS)
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Vaginal self-sampling; STI; Genital infection; Group B streptococcus
Cardiopulmonary Effects of Intrathoracic Pressure Overshoot During Carbon Dioxide Insufflation in Thoracoscopic Surgery
Condition: Esophageal Neoplasms
MeSH terms: Esophageal Neoplasms
Study type: Interventional

Summary: 
      Video-assisted thoracoscopic surgery (VATS) has become a standard technique for addressing
      all types of thoracic pathology. Insufflation of carbon dioxide (CO2) into the operated chest
      cavity could increase lung collapse and improve surgical field view. The actual thoracic
      pressure values may not be identical with the presetting on the insufflator display. This
      overshoot pressure during VATS may compromise cardiac and pulmonary function. The purpose of
      this study is to evaluate the effects of intrathoracic pressure overshoot during two-lung
      ventilation on the hemodynamic and respiratory function and clarify the relative safety of
      two different techniques of insufflation.
    


Intervention name(s): Insufflation of carbon dioxide (CO2)
Intervention type(s): Device
Intervention description(s): After patients were positioned, CO2 was insufflated into right pleural cavity at eight or twenty L/min. during video-assisted thoracoscopic surgery, thoracic pressure, hemodynamic and respiratory parameters were recorded.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Care Provider, Outcomes Assessor)
Primary purpose: Prevention
Keywords: Circulatory and Respiratory Physiological Phenomena; Thoracoscopy
The Identification and Characterization of Autonomic Dysfunction in Migraineurs With and Without Auras
Condition: Migraine
MeSH terms: Autonomic Nervous System Diseases; Primary Dysautonomias
Study type: Observational

Summary: 
      This is a study to compare subject response and symptoms resulting from administration of
      three clinical assessments.

      * The 3 assessments are

        1. passive upright tilt table testing,

        2. quantitative sudomotor axon reflex testing (QSART)and

        3. punch biopsy.

      The comparison of results will be from two subject groups:

        -  Group A, the migraine suffering patient with or without aura

        -  Group B, the migraine suffering patient with or without aura who has diagnosed
           orthostatic intolerance (i.e.,feeling dizzy or faint when making a body position
           change).
    


Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Adult Migraineurs with and without auras, half having orthostatic intolerance.
      
Keywords: autonomic; orthostatic; syncope; biopsy; prevalence of autonomic dysfunction in migraineurs with orthostatic intolerance; characterize autonomic findings utilizing neurocardiac testing, neurophysiological testing and skin biopsies to analyze autonomic fibers in the dermis
Plasmapheresis: a Multi-modal Approach
Condition: Plasmapheresis; Haematology; Sport Performance; Body Composition; Inflammation; Immunology; Adverse Events
MeSH terms: Inflammation
Study type: Interventional

Summary: 
      Only very few studies have prospectively looked at the effect of repeated intensive plasma
      donation. In collaboration with the Rode Kruis Vlaanderen, we have recently found that
      repeated whole blood donation with a 3-month interval in between induced a drop in markers
      for iron status, which worsened with the number of donations. The repetition effect of the
      donations, whether whole blood or plasma, can be different from the effects measured after
      one single donation. It is therefore critical to test and document this repetitive effect to
      build trustable and valid guidelines concerning repetitive plasma donation.
    


Intervention name(s): Plasmapheresis
Intervention type(s): Device
Intervention description(s): Plasma donation at different frequencies
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Health Services Research
Reducing Suicidal Ideation Through Treatment of Nightmares-Post Traumatic Stress Disorder (PTSD)
Condition: Post Traumatic Stress Disorder; Suicidal Ideation; Nightmares
MeSH terms: Stress Disorders, Traumatic; Stress Disorders, Post-Traumatic; Suicidal Ideation
Study type: Interventional
Phase: Phase 4

Summary: 
      Patients with PTSD, and frequent nightmares, and mild-moderate suicidal ideation, who are
      already taking a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Norepinephrine
      Reuptake Inhibitor (SNRI) will be randomized to either prazosin or placebo. The investigators
      hypothesize that patients receiving prazosin will have a greater reduction in suicidal
      ideation.
    


Intervention name(s): Prazosin; Placebo
Intervention type(s): Drug; Drug
Intervention MeSH terms: Prazosin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Cumulative Live Birth Rates in Patients With Repeated Implantation Failure (RIF) Undergoing Preimplantation Genetic Screening (PGS )
Condition: Infertility; Preimplantation Genetic Screening
MeSH terms: Infertility
Study type: Observational

Summary: 
      This is a single centre retrospective study in repeated implantation failure patients: < 39
      years old, at least 4 D3 good quality embryos or 2 good quality blastocysts transferred
      without implantation, absence of known causes of implantation failures (uterine malformation,
      thrombophilia, severe male factor, uncontrolled thyroid disfunction, autoimmune disease).

      Patients scheduled for PGS underwent one or more stimulation cycles (oocyte or blastocyst
      banking) in order to maximize chances of embryo transfer. PGS cycles are analyzed globally.
      Aditionally, PGS cycles with a single stimulation cycle are analyzed in comparison to
      standard IVF cycles.
    


Intervention name(s): PGS (Preimplantation Genetic Screening) with trophectoderm biopsy
Intervention type(s): Procedure
Intervention description(s): PGS (Preimplantation Genetic Screening) with trophectoderm biopsy using arrays comparative genomic hybridizatioon (aCGH)
Observational model: Cohort
Time perspective: Retrospective
Sampling method: Probability Sample
Study population: 
        Repeated implantation failure patients: patients <39 years old that have received at least
        4 day 3 good quality embryos or 2 good quality blastocists with no implantation.
Diffusion Weighted Magnetic Resonance Imaging for Preoperative Staging in Gastric Adenocarcinoma Patients
Condition: Gastric Adenocarcinoma
MeSH terms: Adenocarcinoma; Body Weight
Study type: Interventional
Phase: Early Phase 1

Summary: 
      Preoperative staging for gastric adenocarcinoma is an important procedure to detect advanced
      disease stateS for the patients in which the surgery may be unnecessary to perform. Although
      there are many imaging techniques for this purpose, sensitivity and specificity of these
      techniques still remains to be low.Preoperative detection of peritoneal carcinomatosis and
      involvement of lymph nodes beyond D2 may prevent surgical procedures.

      Removal of the determined lymph nodes according to the type of the surgery is the accepted
      surgical method. However, accurate determination of malignant lymph nodes may prevent
      dissection of some groups of the lymph nodes. These findings may cause a new definition of
      gastric lymph node dissection.
    

Detailed description: 
      1. proven endoscopic diagnosis of gastric adenocarcinoma

        2. for staging purposes, computed tomography for all patients

        3. evaluation of benign and malignant lymph nodes according to computed tomography findings
           and mapping of the lymph nodes

        4. to state precisely resectable patients according to computed tomography and anesthetic
           evaluation

        5. evaluation of benign and malignant lymph nodes according to diffusion weighted magnetic
           resonance imaging findings and mapping of the lymph nodes

        6. standard gastrectomy and D2 lymph node dissection

        7. mapping of the lymph nodes after taking the specimen out

        8. histopathological diagnosis of the lymph nodes and mapping

        9. comparison of the results taken from computed tomography, diffusion weighted magnetic
           resonance imaging and histopathological analysis
    

Intervention name(s): diffusion weighted magnetic resonance imaging
Intervention type(s): Procedure
Intervention description(s): for diagnostic purposes, diffusion weighted magnetic resonance imaging in all patients
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: diffusion weighted; magnetic resonance imaging; surgery; histopathology
The Role of Circulating Soluble CD74 in Acute Lung Injury
Condition: Acute Lung Injury; Acute Respiratory Distress Syndrome
MeSH terms: Respiratory Distress Syndrome; Respiratory Distress Syndrome, Newborn; Acute Lung Injury; Lung Injury
Study type: Observational

Summary: 
      Efforts to identify circulating factors that predict severity of acute lung injury/acute
      respiratory distress syndrome（ALI/ARDS） patients is unrevealing. The primary purpose of this
      study is to verify our hypothesis that soluble CD74 might be a potential novel ALI/ARDS
      biomarker.
    

Detailed description: 
      Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a devastating cause
      of morbidity and mortality characterized by alveolar epithelial and endothelial injury.
      Despite recent advances in pathogenetic mechanisms and therapy strategies of ALI, efforts to
      identify circulating factors that predict severity of ALI/ARDS patients have been
      unrevealing.

      CD74 (also known as a major histocompatibility complex (MHC) class II invariant chain) is a
      type II transmembrane protein, recently found to be the high-affinity receptor of macrophage
      migration inhibitory factor (MIF). MIF promotes neutrophil accumulation in alveolar space via
      binding to CD74 expressed on the cell surface. Our previous study， consistent with others,
      has shown that MIF was highly expressed in acute lung injury (ALI). In addition, we also
      detected highly CD74 expression in lipopolysaccharide (LPS)-induced ALI mouse model.
      Recently, a circulating form of CD74 was discovered in autoimmune liver disease. Similarly,
      we investigated the existence of soluble form of CD74 in serum and bronchoalveolar lavage
      fluid (BALF) in ALI mouse model and burn or trauma related ALI patients. Based on these
      finds, we postulated that soluble CD74 might participate in regulating lung inflammation and
      be a potential novel ALI/ARDS biomarker.
    

Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with and without ARDS were screened from Changhai Hospital. Patients were enrolled
        consecutively over a 2-year time period (2014-2015). All enrolled patients with ALI met the
        American-European Consensus Committee criteria.In addition, healthy individuals were
        recruited from the general population.
      
Biospecimen description: 
      ARDS patients and healthy volunteers
Body Fat Distribution and Its Associated Factors in Chinese Women With Polycystic Ovary Syndrome
Condition: Polycystic Ovary Syndrome (PCOS)
MeSH terms: Polycystic Ovary Syndrome; Syndrome
Study type: Observational

Summary: 
      To investigate the body fat distribution in chinese women with polycystic ovary syndrome
      (PCOS) and the association of those distribution with metabolic parameters, microeconomics,
      hormone profiles and psychological state.
    

Detailed description: 
      The polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic
      disorders in women of reproductive age. It is also one of the leading causes of anovulatory
      infertility and secondary amenorrhea, which represent major stress factors in the female
      life. In the previous studies, the investigators found that PCOS patients showed decreased
      quality-of-life and increased psychological disturbances compared with healthy controls. Body
      mass index (BMI) was associated with emotional disorders and physical aspects of
      quality-of-life and negative emotions were negatively correlated with BMI in PCOS
      patients.These results prompted that PCOS could be separated into at least two subtypes by
      the fat content. So the investigators expand the epidemiological investigation for comparing
      the body composition between the PCOS and the normal women, and finding specific biological
      indicators in different subtypes.
    

Intervention name(s): Clinical data collection
Intervention type(s): Other
Intervention description(s): Basic characteristics: Participants were carefully characterized with regard to a general health history, a medical history, clinical, demographic and anthropomorphic measurements, skin problems (hirsutism is modified by Ferriman-Gallwey (mF-G) score , global acne score and premature alopecia).
A transvaginal ultrasound scan was performed on every participant during a clinical examination to determine the number of follicles and ovarian volume.
Metabolic and other assessments: General gynecological examination, prolactin, thyroid, androgen, LH, FSH, DA, 5-HT, metabonomics, glucose, insulin, triglyceride (TG), LDL and HDL were determined, OGTT was performed.
Questionnaires: The perceived stress scale(Chinese 14-item PSS), self-rating anxiety scale (SAS）, self-rating depressive scale(SDS) were used to assess the participants' mental health status. The MOS item short from health survey (SF-36) was used to assess the quality of life .
Observational model: Other
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        a cross-sectional study was conducted in women of reproductive age (19- 45 years) from the
        Peking university third hospital
      
Biospecimen description: 
      blood samples
    
Keywords: fat distribution; insulin resistance; negative emotion; polycystic ovary syndrome (PCOS)
Effect of Vitamin D on the Honeymoon Period in Children and Adolescents With Type 1 Diabetes
Condition: Type 1 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Interventional

Summary: 
      The purpose of this study is to determine if supplementation with Vitamin D in children and
      adolescents with newly diagnosed type 1 diabetes increases the number of patients who enter
      the honeymoon period.
    

Detailed description: 
      Type 1 diabetes is an autoimmune disease characterized by destruction of the insulin
      secreting beta-cells of the pancreas. There is evidence that Vitamin D may play a role in the
      initial risk of development of autoimmune disease, including type 1 diabetes. However,
      Vitamin D may also play a role the natural progression of type 1 diabetes by altering innate
      insulin secretion and sensitivity and by influencing systemic inflammation, directly at the
      level of the beta-cell. Studies have shown that Vitamin D insufficiency or deficiency is
      frequently reported in children and adolescents with type 1 diabetes. A majority of newly
      diagnosed patients with type 1 diabetes enter a period of partial clinical remission,
      characterized by low or even absent insulin requirements, also known as a honeymoon period.
      This honeymoon period is associated with improved metabolic control, near normal insulin
      sensitivity, and recovery of beta-cell function leading to preservation of endogenous insulin
      secretion. We hypothesize that supplementation with Vitamin D in children and adolescents
      with newly diagnosed type 1 diabetes will halt the destructive process within the beta cell
      and improve beta-cell function by increasing endogenous insulin secretion and decreasing
      systemic inflammation, thereby increasing the rate of partial clinical remission.
    

Intervention name(s): Vitamin D; Placebo
Intervention type(s): Drug; Drug
Other intervention name(s): Cholecalciferol
Intervention MeSH terms: Vitamin D; Cholecalciferol
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Keywords: Type 1 Diabetes; Vitamin D; Clinical Remission
Effect of Dietary Flavonoids on Intestinal Microbiota, Intestinal Inflammation and Metabolic Syndrome
Condition: Metabolic Syndrome X; Inflammation
MeSH terms: Metabolic Syndrome; Syndrome; Inflammation
Study type: Interventional

Summary: 
      The investigators have hypothesized that dietary flavonoids reduce insulin resistance and
      subclinical inflammation secondary to reductions in intestinal inflammation and permeability
      and that these events are mediated through alterations in gut microbiota composition. To test
      this hypothesis, 30 overweight/obese men and women will be provided two well-controlled diets
      that are identical in macronutrient content (Protein, 17% en; Fat, 30% en; Carbohydrate, 53%
      en), but differ markedly in flavonoid content (Low Flavonoid Diet, 10 mg/1000 Kcals; High
      Flavonoid Diet, 340 mg/1000 Kcals). All meals for both diets will be prepared and fed for 6
      weeks each in a randomized cross-over design with endpoints determined in duplicate during
      the last week of each diet period.
    


Intervention name(s): High Dietary Flavonoids; Low Dietary Flavonoids
Intervention type(s): Other; Other
Intervention description(s): A prepared diet consisting of whole foods with a macronutrient composition of 17% en from protein, 30% en from fat and 53% energy from carbohydrate and containing high levels of dietary flavonoids including anthocyanins, flavanones, flavan-3-ols, flavonols, flavones, and polyflavonoids.; A prepared diet consisting of whole foods with a macronutrient composition of 17% en from protein, 30% en from fat and 53% energy from carbohydrate and containing low levels of dietary flavonoids including anthocyanins, flavanones, flavan-3-ols, flavonols, flavones, and polyflavonoids.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: flavonoids; insulin resistance; plasma lipids; intestinal microbiome; intestinal inflammation; subclinical inflammation