bioihbjkbjnl/mcl2 huggingface dataset:
Effects of Polyvinylpyrrolidone Iodine on Postoperative Trismus and Swelling During Impacted Third Molar Surgery
Condition: Impacted Third Molar Tooth
MeSH terms: Tooth, Impacted; Trismus
Study type: Interventional
Phase: Phase 4

Summary: 
      The aim of the present study was to evaluate the effects of different concentrations of
      povidone iodine (PVP-I) on postoperative swelling and trismus when used as a coolant and
      irrigation solution during the surgical removal of impacted mandibular third molars.
    


Intervention name(s): Control; 0.5% concentration of PVP-I; 1 % concentration of PVP-I; 3 % concentration of PVP-I
Intervention type(s): Procedure; Procedure; Procedure; Procedure
Intervention description(s): During the third molar extraction the saline solution will be used in the control group.; During the third molar extraction 0.5% concentration of PVP-I solution will be used in the test group.; During the third molar extraction 1 % concentration of PVP-I solution will be used in the test group.; During the third molar extraction 3 % concentration of PVP-I solution will be used in the test group.
Intervention MeSH terms: Povidone-Iodine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: third molar surgery; povidone iodine
Multimodal Sleep Intervention Using Wearable Technology
Condition: Drinking, Alcohol
MeSH terms: Alcohol Drinking
Study type: Interventional

Summary: 
      This research study is examining three different components of a mobile sleep intervention:
      web-based sleep hygiene advice, sleep and alcohol diary self-monitoring, and personalized
      sleep and alcohol consumption feedback. The study is designed to find out which of these
      components are most effective for mitigating alcohol use disorders and improving sleep
      quality among young adults. The study has three parts: 1) an intake session; 2) a 2-week
      treatment phase; and 3) three follow-up visits over the next 10 weeks.
    

Detailed description: 
      Targeting sleep concerns may be a novel strategy for reducing increased risk of alcohol use
      disorders in young adults. The current study will develop and test a mobile intervention
      addressing sleep concerns in 120 heavy-drinking young adults. All participants will wear
      sleep and alcohol trackers daily. Participants will be randomized to one of three
      interventions. The primary intervention (60 participants) will include web-based sleep
      hygiene advice + sleep/alcohol diary self-monitoring + sleep/alcohol data feedback. The
      comparison interventions will be compared to matched control conditions only including these
      components: (1) web-based sleep hygiene advice (30 participants) or (2) web-based sleep
      hygiene advice + sleep/alcohol diary self-monitoring (30 participants). The primary objective
      is to evaluate sleep intervention component feasibility, acceptability, and preliminary
      efficacy on alcohol outcomes to inform a Stage II randomized trial comparing the final sleep
      intervention with a standard alcohol intervention.
    

Intervention name(s): Advice; Self-monitoring; Feedback
Intervention type(s): Behavioral; Behavioral; Behavioral
Intervention description(s): Once per week for two weeks, participants will come to in-person visits to receive brief web-based sleep hygiene advice.; Participants will complete daily web-based sleep and alcohol diaries for two weeks.; Participants will receive feedback once per week for two weeks on their sleep and alcohol consumption, using all possible data derived from Fitbit actigraphs and Milo Sensor blood-alcohol trackers.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Random assignment to one of three groups in 2:1:1 ratio, each group receiving some variation on 2-week intervention. Measurements taken at baseline, 4 weeks, 8 weeks, 12 weeks.
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Sleep Disorders; Self-Management; Telemedicine; Health Education; Wearable Electronic Devices
FSME IMMUN NEW Follow-up to Study 199 in Children Aged 1 to 6 Years
Condition: Encephalitis, Tick-borne
MeSH terms: Encephalitis, Tick-Borne; Encephalitis
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to investigate the safety and immunogenicity of the third
      vaccination with one of three different concentrations of a TBE vaccine in all subjects who
      completed two vaccinations in one of the three treatment groups of Baxter study 199 (a
      dose-finding study to investigate the safety and immunogenicity of two vaccinations with FSME
      IMMUN NEW in healthy subjects aged 1 to 6 years).
    


Intervention name(s): Tick-Borne Encephalitis (TBE) Vaccine (Inactivated)
Intervention type(s): Biological
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double
Reactogenicity, Safety and Immunogenicity of a TB/FLU-01L Tuberculosis Vaccine
Condition: Tuberculosis
MeSH terms: Tuberculosis
Study type: Interventional
Phase: Phase 1

Summary: 
      The study is a single centre, phase I, open, randomized, by intranasal and sublingual
      application trial that explored the safety and immunogenicity of 2 doses (Day 1 and Day 21)
      TB/FLU-01L tuberculosis vaccine in BCG-vaccinated healthy adult subjects aged 18-50 years.
    


Intervention name(s): TB/FLU-01L; TB/FLU-01L
Intervention type(s): Biological; Biological
Intervention description(s): TB / FLU-01L (intranasal application); TB/FLU-01L (sublingual application)
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: influenza vector; tuberculosis; vaccine
A Study in Subjects With Relapsing-Remitting Multiple Sclerosis (RRMS) to Assess the Efficacy, Safety and Tolerability of Glatiramer Acetate (GA) Injection 40 mg Administered Three Times a Week Compared to Placebo
Condition: Relapsing Remitting Multiple Sclerosis
MeSH terms: Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Sclerosis
Study type: Interventional
Phase: Phase 3

Summary: 
      The study is designed to assess the efficacy of Glatiramer Acetate (GA) injection 40 mg
      administered three times a week compared to placebo in subjects with RRMS, as measured by the
      number of confirmed relapses during the 12 month placebo controlled period. The study has two
      periods:

        -  Placebo Controlled Period: 12 months of 40 mg administered three times a week by
           subcutaneous injection or matching placebo.

        -  Open Label Extension Period: All subjects will continue treatment with GA 40 mg
           administered three times a week, until this dose strength is commercially available for
           the treatment of relapsing remitting multiple sclerosis (RRMS) patients or until the
           development of this GA dose regimen is stopped by the Sponsor
    

Detailed description: 
      Participants who were randomized to the GA 40 mg treatment arm in the Double-Blind Period,
      continue that treatment in the Open-Label Extension Period and are referred to as "Early
      Start" participants. Participants randomized to the Placebo arm in the Double-Blind Period
      and switched to GA 40 mg subcutaneous injections three times a week in the Open-Label
      Extension are referred to as "Delayed Start" participants.
    

Intervention name(s): Glatiramer acetate (GA); Placebo
Intervention type(s): Drug; Drug
Intervention description(s): GA 40 mg/mL administered 3 times a week by subcutaneous injection for a period of 12 months for participants assigned to GA treatment in the Double-Blind Period, and GA 40 mg/mL administered 3 times a week by subcutaneous injection for all participants in the Open-Label Extension Period.; Placebo comparator administered by subcutaneous injection three times each week for 12 months during the Double-Blind Period.
Other intervention name(s): Copaxone
Intervention MeSH terms: Glatiramer Acetate; (T,G)-A-L
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Relapsing Remitting Multiple Sclerosis; Glatiramer Acetate
Individual Differences in the Response to Drugs
Condition: Healthy
Study type: Interventional

Summary: 
      The purpose of this study is to examine whether individual differences in acute responses to
      drugs co-vary across three drugs from different drug classes: alcohol, amphetamine and
      delta-9-tetrahydrocannabinol (THC). The investigators hypothesize that individuals who
      experience greater rewarding effects from one drug will also experience more rewarding
      effects from the other drugs.
    

Detailed description: 
      Here, the investigators aim to investigate whether individuals exhibit similar responses to
      three different drugs from different classes. This study used a within-subjects design (total
      N = 24). All subjects received alcohol, amphetamine and delta-9-tetrahydrocannabinol (THC) in
      a double-blind, double-dummy fashion. Subjects completed six sessions wherein they received
      either alcohol, amphetamine, or THC, or corresponding placebos, on separate days. Subjects
      completed questionnaires about mood, general drug effects, and specific drug effects.
    

Intervention name(s): THC; AMP; ALC; Placebo capsules; Placebo beverage
Intervention type(s): Drug; Drug; Drug; Drug; Drug
Intervention description(s): This is a within-subjects, double-blind, placebo controlled design. We administered oral THC to healthy volunteers to measure their subjective response, which we later compared to their responses to two other drugs.; This is a within-subjects, double-blind, placebo controlled design. We administered AMP to healthy volunteers to measure their subjective response, which we later compared to their responses to two other drugs.; This is a within-subjects, double-blind, placebo controlled design. We administered alcohol to healthy volunteers to measure their subjective response, which we later compared to their responses to two other drugs.; This is a within-subjects, double-blind, placebo controlled design. We administered size 00 gelatin capsules containing dextrose to healthy volunteers as a control for when they received either amphetamine or THC.; This is a within-subjects, double-blind, placebo controlled design. We administered a drink containing cranberry juice plus 1% alcohol added as a taste mask.
Other intervention name(s): delta-9-tetrahydrocannabinol; d-Amphetamine; Alcohol; Sugar Pills
Intervention MeSH terms: Dronabinol; Amphetamine; Dextroamphetamine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Subjective Effects; Alcohol; Amphetamine; THC; Personality
Effect Of Schroth Method On Balance In Upper Crossed Syndrome
Condition: Postural; Defect
Study type: Interventional

Summary: 
      The study will be conducted to investigate the effect of Schroth method on balance in
      patients with the upper cross syndrome
    

Detailed description: 
      Upper crossed syndrome (UCS) is the most common postural dysfunction in the musculature of
      the shoulder girdle /cervicothoracic region, which creates joint dysfunction, particularly at
      the atlanto-occipital joint, cervicothoracic joint C4-C5 segment, glenohumeral joint and
      T4-T5 segment.

      The Schroth method helps patients to halt curve progression, reverse abnormal curves, reduce
      pain, increase vital capacity and improve posture and appearance The Schroth method consists
      of sensorimotor, postural, and breathing exercises aimed at recalibration of normal postural
      alignment, static and dynamic postural control and spinal stability.

      There are no studies on Schroth method on the upper cross syndrome, so this study will be
      conducted to know the effective method of treatment for upper cross syndrome.. forty patients
      with the upper cross syndrome will be allocated randomly to two equal groups; one
      experimental group will receive Schroth method twice a week for four weeks and control group
      will receive postural correction exercise twice a week for four weeks.
    

Intervention name(s): schroth exercise; postural correction exercise
Intervention type(s): Other; Other
Intervention description(s): the patients will receive the Schroth three-dimensional exercise. patient first assumes a posture in the cervico-cranial and shoulder girdle and the thoracic region is held in the correct posture. The patient inspires air into the concave side and during the exhalation phase isometric and isotonic muscle tensing occur. While the patient is breathing, the therapist should observe the posture and movement of the thoracic cage and diaphragm. Basic posture correction in sitting and walking and Sensorimotor training by the ball will be applied; the patients will receive postural correction exercises, stretches, and exercises to the pectoralis major, elevator scapulae, upper trapezius, serratus anterior, rhomboids, and deep neck flexors. The stretches included sitting chair stretches, Brugger's, wall angels, and doorway stretches. The exercises included push up- plus, head-neck-retraction, and Kibler squeeze
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Schroth exercise and postural correction group
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Schroth Method; upper cross syndrome; balance
Sunstone IPL (Intense Pulsed Light) for Hair Reduction
Condition: Hair Removal
Study type: Interventional

Summary: 
      This is a prospective, multi-center, single-arm, single blinded study to evaluate the safety
      and efficacy of the Sunstone IPL (Intense Pulsed Light) device to remove hair.
    

Detailed description: 
      Prospective, multi-center, single-arm, single blinded (Philips hair counter) study in healthy
      women of skin types I up to and including V.

      Safety and efficacy of hair removal with the Investigational Philips IPL-device will be
      investigated.

      In-clinic, each study subject will undergo twelve IPL-treatments at four areas bilaterally
      (face, axilla, bikini line, and legs) with an investigational IPL device applied by a device
      operator.

      Hair re-growth in four body areas, face, axillae, bikini line and leg will be evaluated
      separately.

      After the 4 bi-weekly treatments, one follow-up visit will be organized. After the completion
      of full treatment cycle (12 treatments), subjects will be followed for 1 and 3 months
      (short-term follow-up) and for 6, 9 and 12 months (long-term follow up).
    

Intervention name(s): Treatment with IPL device
Intervention type(s): Device
Intervention description(s): Exposure of body parts to the IPL device
Intervention model: Single Group Assignment
Intervention model description: All enrolled subjects will be treated with the investigation device.
Masking: None (Open Label)
Primary purpose: Treatment
Clinical Trial To Evaluate ANT-1207 In Subjects With Crow's Feet
Condition: Lateral Canthal Lines; Crow's Feet
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to provide evidence of the safety, tolerance, and efficacy of
      ANT-1207 in the treatment of Crow's Feet.
    


Intervention name(s): ANT-1207; Botulinum Toxin, Type A; Botulinum Toxin Type A
Intervention type(s): Biological; Biological; Biological
Intervention description(s): The interventions differ by dose of investigational product applied.; The interventions differ by dose of investigational product applied.; The interventions differ by dose of investigational product applied.
Intervention MeSH terms: Botulinum Toxins; Botulinum Toxins, Type A; abobotulinumtoxinA
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Lateral Canthal Lines; Crow's Feet
Yoga Chikitsa for Neck Pain Caused by Cervical Spondylosis
Condition: Cervical Spondylosis
MeSH terms: Spondylosis; Neck Pain
Study type: Interventional

Summary: 
      Neck Pain caused by Cervical spondylosis (CS) is one of the most common health complaints.
      Despite its frequency as clinical problem worldwide, there are few evidence-based studies
      that document efficacy of therapies for neck pain. The aim of this study was to evaluate the
      effects of Yoga chikitsa (Yoga therapy) on pain and quality of life (QOL) in CS patients
      compared to usual care.
    


Intervention name(s): Yoga Chikitsa; Usual care
Intervention type(s): Other; Drug
Intervention description(s): Intervention consisted of combination of static movements, yoga style exercise, yoga postures, breathing practices, relaxation and yoga counselling.; Intervention included pain medications and exercise movements for neck.
Other intervention name(s): Yoga therapy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Atomoxetine Treatment for ADHD and Marijuana Dependence
Condition: Marijuana Abuse; Attention Deficit Disorder With Hyperactivity
MeSH terms: Marijuana Abuse; Attention Deficit Disorder with Hyperactivity
Study type: Interventional
Phase: Phase 2

Summary: 
      The aim of the study is to determine if atomoxetine treatment combined with motivational
      enhancement therapy is effective in reducing marijuana use in adult individuals with
      attention-deficit hyperactivity disorder and marijuana dependence.
    

Detailed description: 
      The purpose of this study is to determine whether the medication atomoxetine, or Strattera,
      plus 3 sessions of counseling can help people to reduce the symptoms of ADHD and to help cut
      back on their marijuana use. Participation in the study is approximately 12 weeks of
      medication treatment and doctor's visits once a week. The first 2 visits consist of
      evaluations to determine if you qualify to participate. These visits are approximately 2-3
      hours long and will include questions about your past and present substance use, psychiatric
      history, a routine physical exam, bloodwork, and paper and pencil questionnaires about your
      marijuana use. Once you are enrolled in the study, visits are typically 30 minutes long, once
      a week. The one-on-one counseling sessions regarding marijuana use are 1 hour long and you
      will have 3 sessions throughout the study. If you qualify for this study, you will receive
      either atomoxetine, or a placebo (sugar pill). Study participants will have a 50% chance of
      receiving atomoxetine. Atomoxetine is a non-stimulant, commonly used to treat ADHD.
    

Intervention name(s): Atomoxetine; Motivational enhancement therapy; Placebo
Intervention type(s): Drug; Procedure; Drug
Intervention description(s): 25 to 100 mg daily; Three sessions; 25 to 100 mg daily
Other intervention name(s): Strattera; MET; Sugar pill
Intervention MeSH terms: Atomoxetine Hydrochloride
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Immunogenicity And Safety of COVID-19 Vaccine , Inactivated Co -Administration With EV71 Vaccine (Vero Cell)
Condition: COVID-19
MeSH terms: COVID-19
Study type: Interventional
Phase: Phase 4

Summary: 
      This study is a randomized and controlled Phase IV clinical trial of the COVID-19 vaccine
      (Vero cell), Inactivated manufactured by Sinovac Research & Development Co., Ltd. The purpose
      of this study is to evaluate the immunogenicity and safety of COVID-19 vaccine (Vero cell),
      Inactivated co-administration with EV71 vaccine
    

Detailed description: 
      This study is a randomized and controlled phase IV clinical trial in children aged 3-5 years
      old. The purpose of this study is to evaluate the immunogenicity and safety of COVID-19
      vaccine (Vero cell), Inactivated co-administration with EV71 vaccine.The COVID-19 vaccine was
      manufactured by Sinovac Research & Development Co., Ltd and the EV71 vaccine was manufactured
      by Sinovac Biotech Co.A total of 520 subjects aged 3-5 years old will be enrolled.Subjects
      will be randomly divided into 2 groups in a ratio of 1:1.The experimental group is the
      combined immunization group, which will receive the first dose of COVID-19 vaccine and the
      first dose of EV71 vaccine on day 0 and the second dose of COVID-19 vaccine and EV71 vaccine
      on day 28;Control group is the Non-combined immunization group , which will receive the first
      dose of COVID-19 vaccine on day 0 ,the first dose of EV71 vaccine on day 14, the second dose
      of COVID-19 vaccine on day 28 and the second dose of EV71 vaccine on day 42.
    

Intervention name(s): Experimental Group
Intervention type(s): Biological
Intervention description(s): The COVID-19 vaccine was manufactured by Sinovac Research & Development Co., Ltd, and the EV71 vaccine was manufactured by Sinovac Biotech Co.The COVID-19 vaccine:600SU inactivated virus in 0.5mL of aluminium hydroxide solution per injection;The EV71 vaccine:Inactivated EV71 virus antigen no less than 3.0EU in 0.5 mL of aluminium hydroxide solution per injection.
Other intervention name(s): Combined immunization group
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Impact of Conservative Treatment by Custom-made Orthoses in Patients With Haemophilic Ankle Arthropathy
Condition: Haemophilia A; Haemophilia B
MeSH terms: Hemophilia A; Hemophilia B
Study type: Interventional
Phase: Phase 4

Summary: 
      The purpose of this study intend to evaluate the effectiveness of functional orthoses
      (including custom-made insoles and shoes) for preventing and controlling repetitive
      haemarthrosis in patients suffering of haemophilic ankle arthropathy, as well as the
      orthoses' impact on foot health-related quality of life.
    


Intervention name(s): custom-molded insoles and custom-molded shoes
Intervention type(s): Device
Intervention description(s): custom-made insoles in "PELITE" foam (hypoallergenic prosthesis grade foam) or leather top cover cork insoles for patients suffering of mild to moderate ankle arthropathy
custom-molded shoes in leather for patients suffering of end-stage ankle arthropathy
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: patients with haemophilia A moderate or severe; patients with haemophilia B moderate or severe