bioihbjkbjnl/mcl2 huggingface dataset:
Results From a Mexican Acute Promyelocytic Leukemia.
Condition: Promyelocytic Leukemia, Acute
MeSH terms: Leukemia; Leukemia, Promyelocytic, Acute
Study type: Observational

Summary: 
      Retrospective, observational study, comparing treatments of acute promyelocytic leukemia in
      different centers in México.

      There is no sufficient information about acute promyelocytic leukemia in America Latina,
      particularly in Mexico.

      For these reason the investigators started a study adding all promyelocityc patients from the
      main Hospital in Mexico in order to put together a group of patient and analyze the response,
      overall survival and what are the characteristics of the population.

      The investigators included 5 Hospital in Mexico City and states as Monterrey, Guadalajara,
      San Luis Potosi, Puebla, Veracruz, Yucatán, Oaxaca, Guanajuato, Estado de México.

      Even do, the investigators didn´t have arsenic trioxide they are treating patients with
      standard chemotherapy. These paper will help to show the authorities that the cost of
      treating patient with standard chemotherapy is much more higher than ATO-ATRA. The
      investigators are now doing a cost benefit analysis so the investigators, can soon have ATO
      treatment as standard of care in Mexico for the treatment of acute promyelocytic leukemia.
    

Detailed description: 
      A multicentric, retrospective, descriptive, longitudinal study was carried out. Between
      January 2007 and January 2017, patients of both sexes and different ages, who were candidates
      for receiving intensive chemotherapy along with tretinoin were included in the study. The
      diagnosis for Acute Promyelocytic Leukemia was determined based on the following criteria:
      abnormal promyelocytes in the bone marrow and verification of the t(15;17) translocation by
      karyotype or using RT-PCR to determine the genetic lesion and define the type of PML/RARA
      isoform.

      In Mexico the investigators still treating patients with anthracycline and cytarabine +
      transretinoic acid. These information will help the authorities to realize the importance of
      having arsenic trioxide as part of the treatment of these disease, knowing the amount of
      patient that the investigators have in Mexico, knowing that in the hispanic race the
      incidence is greater.
    

Intervention name(s): Diagnosis; Molecular and Karyotype; Leucocytes
Intervention type(s): Diagnostic Test; Diagnostic Test; Diagnostic Test
Intervention description(s): Determine the number of center that are able to process PCR or FISH/Karyotype for PML/RAR or t(15;17); To realize the need of having more center we the technology to perform all of these tests
Other intervention name(s): FISH; Karyotype; PCR; Risk status
Observational model: Other
Time perspective: Retrospective
Sampling method: Non-Probability Sample
Study population: 
        All patient older 15 years old with acute promyelocytic Leukemia treated at a Mecican
        Center
IOBA - Impact on Body Awareness
Condition: Perception, Self; Body Image; Self-Assessment
Study type: Interventional

Summary: 
      Due to social isolation and increased stress factors during the COVID-19 pandemic an increase
      of psychological and psychosomatic complaints in the population can be observed. There is
      growing evidence of the importance of body awareness (BA) in these complaints. The question
      arises how BA can be modified through therapeutic measures. The Awareness Body Chart (ABC),
      an innovative non-verbal tool for investigating subjective body awareness, implemented in
      clinical practice brings to light astonishing findings of patients' bodily experiences which
      have not been collected through verbal communication so far. In a randomized controlled study
      with 96 healthy adults in three groups (massage, gymnastics and control group), the use of
      the ABC questionnaire and further German questionnaires (Short questionnaire on
      self-perception of the body, self-rating mood scale - revised) concerning body awareness and
      well-being should analyse the following hypotheses: Primary hypothesis: There is a difference
      in the change of BA between the massage group and the control group, and there is a
      difference in the change of BA between the gymnastics group and the control group. Secondary
      hypothesis: There is a difference in the change of BA between the massage group and the
      gymnastics group. Before interventions demographic data and further questionnaires concerning
      health conditions of the participants (Simple Physical Activity Questionnaire, Short Form
      Health Survey, Brief Symptom Inventory and additional questions) are administered.
      Correlations between BA and the results of these tests will be investigated too. All these
      analyses can provide innovative information about BA and be indicative in the use of
      physiotherapeutic measures.
    


Intervention name(s): Massage; Gymnastics; Lecture
Intervention type(s): Procedure; Procedure; Other
Intervention description(s): 20-minute manual full-body massage; 20-minute moderate body workout; 20-minute lecture on medicinal herbs
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Basic Science
A Trial Investigating Lu AF28996 in Adult Japanese Participants With Parkinson's Disease (PD)
Condition: Parkinson Disease
MeSH terms: Parkinson Disease
Study type: Interventional
Phase: Phase 1

Summary: 
      This trial will evaluate the effects of Lu AF28996 in adult Japanese men and women with
      Parkinson's disease (PD). The main goals of the trial are to learn more about a) the safety
      and tolerability of Lu AF28996 (any new or worsening medical issues the participants have
      with treatment), and b) the pharmacokinetic parameters of Lu AF28996 (how the drug is
      absorbed, distributed, and processed by the body). Participants will take Lu AF28996 capsules
      orally once a day (OD). The participants will start with a low dose of Lu AF28996, which will
      be increased gradually over a period of 2 weeks, and then decreased gradually over a period
      of about 2 weeks.
    


Intervention name(s): Lu AF28996
Intervention type(s): Drug
Intervention description(s): Hard capsule, orally, per schedule specified in the arm description.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Biological Stardadization of D. Pteronyssinus and D. Farinae Allergen Extracts
Condition: Immune System Diseases
MeSH terms: Immune System Diseases
Study type: Interventional

Summary: 
      Four concentrations of Dermatophagoides pteronyssinus and Dermatophagoides farinae allergen
      extracts, together with a positive and negative control, using 10 mg/ml histamine
      dihydrochloride solution and a glycerinated phenol saline solution, respectively, will be
      tested in every patient in duplicate on the volar surface of the forearm..
    

Detailed description: 
      This is an open, unblinded and non-randomized biological assay. The study design is a slight
      modification of the recommendations proposed by the Nordic Guidelines.
    

Intervention name(s): Allergen extracts
Intervention type(s): Diagnostic Test
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: Immune System Diseases; Prick Test; Dermatophagoides pteronyssinus; Dermatophagoides farinae
Body Image in Youth With HIV
Condition: Human Immunodeficiency Virus; HIV
MeSH terms: Acquired Immunodeficiency Syndrome; HIV Infections
Study type: Observational

Summary: 
      This is an observational study that seeks to gather information about perceptions of body
      image through the use of a one-time questionnaire completed by participants at the time of
      study enrollment.

      Effective management of Human Acquired Immune Deficiency Syndrome (AIDS) caused by the Human
      Immunodeficiency Virus (HIV) has become possible through the use of Highly Active
      Antiretroviral Treatment (HAART). As a result of more successful treatment options, HIV/AIDS
      has transitioned from a terminal illness to one which is treated as a chronic condition. One
      particular group that has been impacted tremendously by HIV in the United States is the
      adolescent population. As youth are living longer with HIV/AIDS, clinicians and researchers
      are beginning to examine ways in which the disease can affect one's physical health, mental
      health, and other psychosocial factors. Research emerging involving adults with HIV/AIDS has
      suggested that increased attention to and negative views of one's body image may be found at
      a higher rate in this group. To our knowledge, very few studies have examined this
      relationship in adolescents with HIV.
    

Detailed description: 
      The purpose of this exploratory study is to characterize body image perceptions among youth
      with perinatally and behaviorally acquired HIV. In a cross-sectional design, adolescents will
      be asked to complete an ACASI questionnaire that will assess body image, medication
      adherence, depressive symptoms, medical, and other sociodemographic variables which may
      relate to adolescents with HIV. Information regarding the adolescents' medical history,
      medications, and physical functioning also will be abstracted from his or her medical record.
      Guided by the Intervention Mapping (IM) approach, findings from this study will inform future
      intervention studies designed to enhance HIV disease management among adolescents.

      PRIMARY OBJECTIVE:

      To characterize body image perceptions among youth with HIV.
    

Intervention name(s): Questionnaire
Intervention type(s): Other
Intervention description(s): The primary outcome, characterizing body image among HIV infected adolescents, will be measured using a questionnaire administered to study participants through Audio Computer Assisted Self-Interview (ACASI) technology.
Other intervention name(s): Audio Computer Assisted Self-Interview; ACASI
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients with documented HIV infection between the ages of 16 and 24 who are willing and
        able to consent.
      
Keywords: Adolescents; Body Image
Open-Label, Extension Study to Evaluate the Safety of Hydrocodone Bitartrate Extended-Release Tablets
Condition: Low Back Pain
MeSH terms: Back Pain; Low Back Pain
Study type: Interventional
Phase: Phase 3

Summary: 
      This is a 6-month, nonrandomized, open-label extension study to assess the long-term safety
      of hydrocodone bitartrate extended-release (ER) tablets in patients with moderate to severe
      chronic low back pain who require continuous opioid treatment for an extended period of time.

      To be eligible for Study 3104, patients were required to have completed the entire double
      blind treatment period on study drug (either placebo or hydrocodone bitartrate ER tablets)
      through week 12 of Study 3103 (NCT01789970) and to have met the entry criteria for Study
      3104.
    

Detailed description: 
      Eligible patients from Study 3103 (NCT01789970) were enrolled for participation in this
      extension study. For these patients, the final study visit in Study 3103 was visit 1 for this
      study (also referred to as the titration or adjustment baseline visit, depending on whether
      the patient was enrolled under the original or amended protocol, respectively). The original
      protocol was amended after 26 patients had been enrolled in the study. Those who were
      enrolled under the original protocol participated in a double-blind titration period of up to
      approximately 4 weeks followed by an open-label treatment period of 22 weeks. Those patients
      who were enrolled under the amended protocol participated in an open-label adjustment period
      of up to approximately 3 weeks followed by an open-label treatment period of 22 weeks.
    

Intervention name(s): Hydrocodone ER; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Participants were instructed to take hydrocodone ER tablets orally with a glass of water on an empty stomach at least 1 hour before or 2 hours after eating.; During the double-blind titration period used in the original protocol, placebo tablets matching each dose of hydrocodone bitartrate ER tablets (active drug) were used to maintain the blind but not for purposes of comparison.
Other intervention name(s): CEP-33237; Hydrocodone bitartrate extended-release tablets
Intervention MeSH terms: Hydrocodone
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: low back pain; hydrocodone bitartrate; opioids
Somesthesic Role of the Ventro-lateral Prefrontal Cortex in Speech Motor Learning
Condition: Speech; Motor Activity
Study type: Interventional

Summary: 
      These studies test the hypothesis that frontal areas of the brain participate in the cortical
      networks involved in the somotosensory processing that happens during speech motor learning.
    

Detailed description: 
      This work aims to study the role of sensory systems in human motor learning and specifically
      addresses the involvement of somatosensory cortical networks in motor learning of speech.
      Previous studies in the literature have highlighted the plasticity of cortical sensory
      networks, notably the primary and secondary somatosensory cortex and the ventral premotor
      cortex, during motor learning tasks. The present project focuses on the somatosensory region
      with connections to the sensorimotor regions of the frontal and parietal cortex. We propose
      to use neuroimaging (fMRI), in order to verify which areas in the prefrontal cortex are part
      of the sensorimotor network used in the learning of speech motor tasks in humans. Subjects
      will be tested in the fMRI scanner while performing either a behavioral task in which the
      auditory feedback of their own speech is altered or while performing a vibrotactile
      discrimination task.
    

Intervention name(s): Speech adaptation; Vibrotactile Discrimination; fMRI; Speech production
Intervention type(s): Behavioral; Behavioral; Other; Behavioral
Intervention description(s): Sensorimotor adaptation in speech; Vibrotactile Discrimination; fMRI measurement of brain activity; Speech production task
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Comparison of Intermittent Occlusion and Static Stretching
Condition: Muscle Soreness
MeSH terms: Myalgia
Study type: Interventional

Summary: 
      To determine changes in Vitals caused by Intermittent Occlusion ( 220 mg ) and to compare the
      effectiveness of Intermittent Occlusion and Static Stretching of the lower limb muscle group
      in preventing the development of exercise induce Muscle Soreness
    

Detailed description: 
      Main purpose of this study is to determine changes in Vitals caused by Intermittent Occlusion
      ( 220 mg ) and to compare the effectiveness of Intermittent Occlusion and Static Stretching
      of the lower limb muscle group in preventing the development of exercise induce Muscle
      Soreness. As muscle soreness is very major and basis problem of every individual , specially
      after enrolling into some physical activity .

      First consent form will be given to both male and female participants from 18 to 25 years of
      age and after that PAR-Q Questionnaire will be filled for every individual, so that we will
      check their readiness for the Exercise then all the four Vitals will measured from every
      individual .They will randomly assigned by lottery method to intervention group and control
      group. Both group individuals will be exerted by Warm up for 5 mints, heel raise in 3 sets
      for 10 to 15 mints until we get 4 on RPE scale, by asking to hold dumbbells of 2 kg on both
      of the hands. Rate of perceived exertion (RPE) is calculated by Borg grading scale .Plus, leg
      circumference, ROM of planter and dorsal flexion and numeric pain rating scale (NPRS) will be
      measured for comparison within and between the groups. Again vitals will be monitored.
    

Intervention name(s): Static Stretching; Intermittent Occlusion
Intervention type(s): Other; Other
Intervention description(s): In Control group all the individuals will be asked to perform static stretching for 10 mints, 1 set . Vitals will be monitored from every individual. On 3rd day to this protocol leg circumference, ROM of planter and dorsal flexion and numeric pain rating scale (NPRS ) will be measured alone with all the Vitals from every individual.; Individuals of Interventional group will be asked to lay down in supine position, apply proximal thigh cuff, 220mg for 12 minutes for intermittent occlusion. During this procedure discomfort will be checked on numeric pain rating scale, if we get 6 on scale, will stop the occlusion. Vitals will be monitored from every individual. On 3rd day to this protocol leg circumference, ROM of planter and dorsal flexion and numeric pain rating scale (NPRS ) will be measured alone with all the Vitals from every individual
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Prevention
Keywords: Muscle soreness; Vital Signs; Intermittent occlusion; Static stretching
Comparison of Bioactive Glass Ceramics Spacer and PEEK Cages in Posterior Lumbar Interbody Fusion: A Prospective, RCT
Condition: Degenerative Lumbar Spinal Stenosis
MeSH terms: Spinal Stenosis
Study type: Interventional

Summary: 
      The authors aimed to compare the clinical efficacy and safety of CaO-SiO2-P2O5-B2O3 glass
      ceramics with PEEK cage that is widely used for posterior lumbar interbody fusion (PLIF)
      surgery in the clinical field.
    


Intervention name(s): NovoMax, BioAlpha Inc, Seong-nam, Korea; PEEK cage
Intervention type(s): Device; Device
Intervention description(s): CaO-SiO2-P2O5-B2O3 glass ceramics spacer; PEEK cage
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Comparison of Airway Intubation Devices When Using a Biohazard Suit
Condition: Intubation; Difficult
Study type: Interventional

Summary: 
      We will investigate the impact biohazard gear has on time to successful intubation and, in
      particular, determine how the Supraglottic Airway Laryngopharyngeal Tube (Ecolab, Columbus,
      Missouri) device compares to traditional direct laryngoscopy and fiber-optic (video)
      intubation techniques.
    

Detailed description: 
      This study will take place in an academic/training facility at Lehigh Valley Health Network
      simulating intubation during a bio-terrorism attack. As a part of their usual (standard of
      care) residency education, the study volunteers will be participating in a day-long airway
      training course in the Fall of 2013 where each of the tested devices will be introduced and
      the residents will be able to practice using them on a variety of training mannequins.

      As part of this training, the enrolled study subjects will be timed using each of three
      intubation devices, both with and without wearing biohazard protective gear, for a total of
      six measurements per resident. Residents will have been assigned chronological numbers as
      they arrived and signed in for the course. These numbers will be also used for study
      identification numbers. Subjects will be randomized by odd or even identification numbers as
      to whether they will make their initial attempt in street clothing or the biohazard suit.
      This will help control for individual subject's skill learning. The subject will then
      intubate the same mannequins using each of the tested devices.

      The order of devices used will be the same as in actual clinical practice: 1) Direct
      Laryngoscopy (the classic standard of care), 2) the GlideScope or C-MAC video laryngoscope
      (fiber-optic technology, which has become increasingly popular among emergency physicians),
      and 3) the Supraglottic Airway Laryngopharyngeal Tube airway device (an inexpensive,
      convenient supraglottic device that allows for a blind intubation technique through the
      device).

      Data will be collected, per device, on the time taken and tubes used for each attempt.
      Demographic information will also be collected from participants such as gender, resident
      year, prior intubation experience, prior exposure to each of the tested devices, and
      experience wearing a biohazard suit. Study participants' satisfaction with each of the
      devices will also be recorded.
    

Intervention name(s): standard clothing; Biohazard gear; Direct Laryngoscopy; Glidescope; Supraglottic Airway
Intervention type(s): Other; Other; Device; Device; Device
Other intervention name(s): (the classic standard of care); Supraglottic Airway Laryngopharyngeal Tube
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Airway
Efficacy of Lappa Arctium (Homoeopathic Medicine) in Treatment of Acne Vulgaris
Condition: Acne Vulgaris
MeSH terms: Acne Vulgaris
Study type: Interventional
Phase: Phase 1

Summary: 
      Acne is one of the most common skin problems in teenagers and adolescents. There are many
      lesser known homoeopathic medicines which have been mentioned in the literature for treatment
      of acne but their potential has not been properly assessed /documented and therefore these
      medicines don't form a part of many prescriptions. As a part of this study,efficacy of Lappa
      Arctium will be studied in the treatment of Acne vulgaris
    


Intervention name(s): Lappa Arctium
Intervention type(s): Drug
Intervention description(s): To start with subjects will be prescribed Lappa Arctium in 6 potency to be taken in form of pills 4 times a day for seven days. Dosage and frequency will be changed, if required, based on the condition of subject and their response according to homoeopathic principles.
Other intervention name(s): Lappa Major
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Acne Vulgaris; Homoeopathy; Lappa Arctium