bioihbjkbjnl/mcl2 huggingface dataset:
Pain Relief Effects on Length of Labor
Condition: Labor Pain
MeSH terms: Labor Pain
Study type: Interventional

Summary: 
      This study divides patients into two groups when they ask for medicine to help relieve the
      pain of contractions. One group will be selected to receive an epidural and another group
      will be selected to receive both a spinal dose and an epidural. The investigators will then
      measure how long it takes to deliver the baby. The investigators think that the group that
      has the combination spinal and epidural will have a faster labor.
    

Detailed description: 
      In this randomized controlled trial, the investigators will evaluate conventional continuous
      lumbar epidural analgesia compared to the combined spinal-epidural analgesia. The primary
      outcome of interest will be duration of the active phase of the first stage of labor.
      Secondary outcomes include the cesarean delivery rate, operative vaginal delivery rate,
      analgesia requirements, maternal and neonatal safety profiles (incidence of maternal
      hypotension, post puncture dural headache, fetal acidemia and NICU admissions, respectively),
      Adequacy of maternal pain relief will also be measured using visual analog scores (VAS). The
      investigators hypothesize that the instantaneous pain relief that is achieved with combined
      spinal-epidural analgesia reduces catecholamines quickly and to a greater degree than the
      conventional epidural, leading to a more effective uterine contraction pattern thus
      decreasing the duration of the active phase of the first stage of labor.
    

Intervention name(s): Combined Spinal-epidural; Continuous Lumbar epidural
Intervention type(s): Procedure; Procedure
Intervention description(s): See arm description; See arm description
Other intervention name(s): Spinal dose: 1 ml of 0.25 % bupivicaine; 20 mcg of fentanyl; Epidural dose: 0.25 % bupivicaine (various amounts according to protocol); fentanyl; 3 ml of 1.5% lidocaine with epinephrine 1:200000; 0.25 % bupivicaine; fentanyl
Intervention MeSH terms: Lidocaine; Epinephrine; Fentanyl; Bupivacaine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Labor; analgesia; epidural; spinal
Anticipatory Guidance to Prevent Childhood Obesity
Condition: Childhood Obesity
MeSH terms: Obesity; Pediatric Obesity
Study type: Interventional

Summary: 
      The purpose of this pilot project is to test anticipatory guidance, which is information
      given to families during a well child visit to prevent obesity during childhood. The
      objectives were to compare two styles of anticipatory guidance during the first year of life,
      maternal focused and infant focused, versus usual care and determine which style, if any,
      showed the most ideal infant feeding behaviors at age 1 year and to see if there were any
      differences in infant weight for height at one year of age. The investigators hypothesized
      that mothers who received the maternal focused anticipatory guidance (which gave information
      on eating family meals, not having tv on during meals, and maternal nutrition) would actually
      have the best infant feeding behaviors and weight for height of infants at one year.
    


Intervention name(s): Maternal focused intervention; Ounce of Prevention
Intervention type(s): Behavioral; Behavioral
Intervention description(s): This is a series of information given to mothers at child's well child visits (6 in all) starting at the newborn visit focused in maternal eating habits, using the mother as a potential 'agent of change' for the family and infant in modeling healthy eating habits.; This intervention is given via a series of handouts given to mothers at their child's well visit from newborn period to one year of age, focusing on serving size and frequency and the introduction of new foods.
Other intervention name(s): MOMS; "Ounce"
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary purpose: Prevention
Keywords: well child visit; anticipatory guidance; obesity prevention; infant feeding
Open-label Comparison of 24hr Gastric pH on Days 1, 2, 7 With Once-daily Administration of Lavoltidine 40 mg.
Condition: Gastroesophageal Reflux Disease; Reflux, Gastroesophageal
MeSH terms: Gastroesophageal Reflux
Study type: Interventional
Phase: Phase 1

Summary: 
      Current treatment for gastroesophageal reflux disease(GERD)confirms an unmet need in
      patients, based on slow onset of action and an inability to provide 24-hour gastric acid
      suppression. Clinical data on lavoltidine demonstrates a rapid onset of action, high potency,
      and prolonged duration of effect after single dose. Since tolerance to the class of compounds
      to which lavoltidine belongs may be dose dependent, the current study is designed to
      determine if 40mg lavoltdine given for 7days develops tolerance.
    


Intervention name(s): Lavoltidine
Intervention type(s): Drug
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Keywords: pharmacodynamics,; tolerance; H2 antagonist,; AH23844,; lavoltidine,; gastroesophageal reflux disease (GERD), pharmacokinetics,
Creative Arts Diabetes Initiative for Youth/Young Adults Transitioning to Adult Care
Condition: Coping Behavior; Emotional Distress; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 1
Study type: Interventional

Summary: 
      The Creative Arts Diabetes Initiative will offer facilitated art therapy with a
      group/peer-support environment to two groups of youth/young adults, one with type 1 diabetes,
      and one with type 2 diabetes. This environment intends to "meet youth where they are",
      promote universality, hope and self-understanding, has the potential to be therapeutic and
      allows youth to express and learn about themselves and each other while developing healthy
      coping skills and address their fears and concerns.
    

Detailed description: 
      The Creative Arts Diabetes Initiative will offer facilitated art therapy with a
      group/peer-support environment to two groups of youth/young adults, one with type 1 diabetes,
      and one with type 2 diabetes. This environment intends to "meet youth where they are",
      promote universality, hope and self-understanding, has the potential to be therapeutic and
      allows youth to express and learn about themselves and each other while developing healthy
      coping skills and address their fears and concerns.

      As much of diabetes management is about meeting physical health goals - it is the vision of
      this study that offering additional support in the form of art therapy will have positive
      effects for bringing awareness and avenues for self-care to the other often neglected
      dimensions of patients' mental, emotional and spiritual health as part of a more holistic
      health process.

      Engaging in art therapy has the potential to decrease diabetes related distress by giving
      youth a means and opportunity to identify, understand and express their feelings about having
      diabetes. Improved self-awareness and self-reflectiveness can help youth integrate their
      feelings and learn how this can motivate, influence and impact their behaviors and life
      choices.

      Youth will have the opportunity for engaging in peer support, and to build relationships that
      are meaningful, thus increasing their sense of belonging and positively affect their level of
      self-confidence, purpose and wellbeing.
    

Intervention name(s): Art therapy - pre and post test measures
Intervention type(s): Behavioral
Intervention description(s): 12 weeks of 90 minutes of art therapy with pre and post test measures to determine changes in social support and levels of diabetes distress
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: type 1 diabetes; type 2 diabetes; children; adolescents; young adults; youth; transition; art therapy; behavioral therapy
The Effects of Smell on Mood and Physical Responses
Condition: Stress; Anxiety; Depression
MeSH terms: Depression
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to examine the body's response to relaxing and stimulating
      fragrances commonly used in aromatherapy.
    

Detailed description: 
      Despite aromatherapy's popularity, efficacy data are scant, and potential mechanisms are
      controversial. This randomized controlled trial examined the psychological, autonomic,
      endocrine, and immune consequences of one purported relaxant odor (lavender), one stimulant
      odor (lemon), and a no-odor control (water), before and after a stressor (cold pressor); 56
      healthy men and women were exposed to each of the odors during three separate visits. To
      assess the effects of expectancies, participants randomized to the "blind" condition were
      given no information about the odors they would smell; "primed" individuals were told what
      odors they would smell during the session, and what changes to expect. Experimenters were
      blind.

      In each case we measured several different aspects of the cellular immune response, as well
      as skin barrier repair following tape stripping. This design allowed us to examine the
      ability of the odors to modulate endocrine and immune function, and health-relevant cutaneous
      responses.
    

Intervention name(s): Exposure to relaxant and stimulant odors
Intervention type(s): Behavioral
Intervention description(s): A yellow-tinted cotton ball containing 100 ml of the essential oil or distilled water was taped between the nose and upper lip on top of a piece of surgical tape; use of the barrier tape avoided percutaneous absorption . This method provided continuous and uniform exposure across subjects that would not have been possible with ambient room inhalation, and helped maintain experimenter blindness.
Other intervention name(s): Citrus: lemon.
Intervention MeSH terms: Central Nervous System Stimulants
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Aromatherapy; Smell
Effect of Metformin on Gut Microbiota Changes and Glycemic Control of Newly Diagnosed Type 2 Diabetes
Condition: Type 2 Diabetes
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 4

Summary: 
      This study was aimed to investigate the effect of metformin on the gut microbiota and
      glycemic control in newly diagnosed type 2 diabetes patients.
    

Detailed description: 
      This study was aimed to investigate the effect of metformin on the gut microbiota and
      glycemic control in newly diagnosed type 2 diabetes patients. All the recurited patients were
      treated with metformin 1500-2000mg daily for 3 months. Stool specimens and blood samples were
      collected at the beginning and 3 months later.
    

Intervention name(s): Metformin Hydrochloride
Intervention type(s): Drug
Intervention description(s): treated with metformin 1500-2000mg daily
Other intervention name(s): intervention group
Intervention MeSH terms: Metformin
Intervention model: Single Group Assignment
Intervention model description: newly diagnosed type 2 diabetes was treated with metfomin for 3 months.
Masking: None (Open Label)
Primary purpose: Treatment
A Study of Tocilizumab in Patients With Active Polyarticular Juvenile Idiopathic Arthritis
Condition: Juvenile Idiopathic Arthritis
MeSH terms: Arthritis; Arthritis, Juvenile
Study type: Interventional
Phase: Phase 3

Summary: 
      This 3-part study evaluated the efficacy and safety of tocilizumab in patients with active
      polyarticular-course juvenile idiopathic arthritis who have an inadequate response to, or
      were intolerant of methotrexate. In Part I of the study, all patients received intravenous
      (iv) infusions of tocilizumab (8 mg/kg for patients ≥ 30kg, 8 mg/kg or 10 mg/kg for patients
      < 30kg) every 4 weeks for 16 weeks. In Part II of the study, patients with an adequate
      response in Part I were randomized to receive either tocilizumab at the same dose as in Part
      I or placebo every 4 weeks for up to 24 weeks. In Part III of the study, patients received
      tocilizumab at the same dose as in Part I every 4 weeks for up to another 64 weeks. Standard
      of care therapy with or without non-steroidal anti-inflammatory drugs (NSAID),
      corticosteroids, or methotrexate was continued throughout the study.
    


Intervention name(s): Tocilizumab; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Tocilizumab was supplied as a sterile solution in vials.; Placebo to tocilizumab was supplied as a sterile solution in vials.
Other intervention name(s): RoActemra; Actemra
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Efficacy and Safety Study of Ozanimod in Ulcerative Colitis
Condition: Ulcerative Colitis
MeSH terms: Colitis; Colitis, Ulcerative; Ulcer
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of this study is to determine whether RPC1063 is effective in the treatment of
      ulcerative colitis (UC).
    


Intervention name(s): Ozanimod; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Ozanimod capsules by mouth daily.
Other intervention name(s): Zeposia, RPC 1063
Intervention MeSH terms: Ozanimod
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Study to Evaluate Safety and Efficacy of PF-06826647 For Moderate To Severe Plaque Psoriasis
Condition: Psoriasis
MeSH terms: Psoriasis
Study type: Interventional
Phase: Phase 2

Summary: 
      This multicenter study is being conducted to provide additional PF-06826647 safety and
      tolerability data, and to further explore the clinical efficacy of PF-06826647 in the
      treatment of moderate to severe plaque psoriasis. Additionally, the study is intended to
      enable selection of oral dose and dosing regimen for the future clinical development of
      PF-06826647.
    


Intervention name(s): PF-06826647 or Placebo; PF-06826647
Intervention type(s): Drug; Drug
Intervention description(s): Delivered orally (tablet) once daily (QD) for 16 weeks during the Investigational Treatment Period; Delivered orally (tablet) once daily (QD) for 24 weeks during the Extension Period
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Automated Analysis Algorithms in Second Trimester Obstetric Ultrasound
Condition: Ultrasonography, Prenatal
Study type: Interventional

Summary: 
      This study aims to evaluate the effect of the use of automated algorithms for the measurement
      of fetal biometry, and for the reconstruction of standard planes of fetal anatomy, compared
      with the standard ultrasound technique, during the second trimester ultrasound scan.
    

Detailed description: 
      In recent years in many ultrasound equipment were fitted with automated algorithms for
      measuring fetal biometry, and for the reconstruction of standard planes of fetal anatomy.
      Although there are studies that have assessed the application of these algorithms in terms of
      repeatability of the measurements made, or of possibility of acquiring diagnostic planes,
      there are no randomized controlled studies that evaluated their impact on the second
      trimester ultrasound scan.

      The aim of the study is to evaluate the effect of the use of automated algorithms for the
      measurement of fetal biometry, and for the reconstruction of standard planes of fetal
      anatomy, compared with the standard ultrasound technique, in terms of:

        -  duration of the ultrasound scan

        -  quality of biometric measurements

        -  quality of the diagnostic planes

        -  operator satisfaction
    

Intervention name(s): Automated algorithms; Standard technique
Intervention type(s): Diagnostic Test; Diagnostic Test
Intervention description(s): Automated algorithms for measuring fetal biometry, and for the reconstruction of standard planes of fetal anatomy; Standard ultrasound examination without use of automated algorithms for measuring fetal biometry, and for the reconstruction of standard planes of fetal anatomy
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Diagnostic
Walking With FES or AFO in People With MS With Foot Drop
Condition: Multiple Sclerosis; Foot Drop
MeSH terms: Multiple Sclerosis; Peroneal Neuropathies; Sclerosis
Study type: Observational

Summary: 
      This investigation consists of two parallel groups of participants who will follow the same
      protocol. The aim of the study is to investigate the effects of using Functional Electrical
      Stimulation/Ankle Foot Orthosis (AFO) or splint as an assistive mobility device over a 12
      week period in people with MS who experience foot drop. Patients who are clinically
      prescribed FES will be invited to participate in the FES arm of the study. Patients who are
      clinically prescribed an AFO will be invited to participate in the AFO arm. Participants will
      be asked to make four visits to the gait laboratory at Queen Margaret University. Four weeks
      before the start of device use (Baseline - 4 weeks), start of device use (Baseline), after 6
      weeks and 12 weeks of device use. Participants' walking will assessed using computerised
      three dimensional motion analysis, which will provide a detailed description of the movements
      (kinematics) of the lower limbs. Participants will also be asked to carry out a 10 metre walk
      and a two minute walk. Both gait analysis and the walking performance tests will be carried
      out with and without an assistive device; apart from their first session where participants
      will only be assessed without their assistive device.

      Participants will be asked to wear an activity monitor for 7 days after each assessment. In
      addition participants will be asked to complete four short standardised questionnaires (MS
      walking scale, MS impact scale (MSIS-29), Fatigue severity score and the Leeds MS Quality of
      life score) at each assessment.
    


Intervention name(s): Functional Electrical Stimulation; Ankle Foot Orthosis
Intervention type(s): Device; Device
Other intervention name(s): Odstock Dropped Foot Stimulator (ODFS) III; ODFS Pace; splint
Observational model: Case-Control
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        People with Multiple Sclerosis who have been prescribed either FES or an AFO to treat foot
        drop by their physiotherapist.
      
Keywords: Multiple Sclerosis; Functional Electrical Stimulation; Ankle Foot Orthosis; Walking performance; gait analysis; fatigue; activity monitoring
Study in Allergic Adults to Support the Development of Immunological Assays
Condition: Immunologic Tests
Study type: Interventional

Summary: 
      The purpose of this study is to develop and characterize immunological assays on blood
      samples.
    

Detailed description: 
      This is a clinical study in which there is no vaccine administered. It is designed for
      research purposes such as developing immunological assays.
    

Intervention name(s): Blood withdrawal
Intervention type(s): Procedure
Intervention description(s): Blood sampling
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Keywords: Immunological assay; Birch allergy
Double-lumen Tube Intubation Technique to Reduce Laryngeal Injuries
Condition: Laryngeal Injuries
MeSH terms: Wounds and Injuries
Study type: Interventional

Summary: 
      The purpose of this study is to devise the method to reduce laryngeal injuries during
      double-lumen tube intubation.
    


Intervention name(s): 90 degrees rotation; 180 degrees rotation
Intervention type(s): Procedure; Procedure
Intervention description(s): Double-lumen tube intubation with 90 degrees rotation; Double-lumen tube intubation with 180 degrees rotation
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: during double-lumen; tube intubation
Gynecological Presentations Following Supracervical Hysterectomy
Condition: Gynecological Survey
Study type: Observational [Patient Registry]

Summary: 
      Supracervical hysterectomy is widely common and had many complications either immediate or
      delayed. In these patients bleeding, infection, chronic pelvic pain are common. In these
      patients cervical biopsy will be done and histopathological examinations will be done to
      evaluate the pathology in these patients.
    

Detailed description: 
      -  Study design and settings: Cross sectional descriptive studies

        -  Patients: 130 patients with hysterectomy recruited at Tanta University Hospital,
           gynecology clinics in central hospitals in Gharbia governorate will be recruited
           according inclusion and exclusion criteria. Inclusion criteria include all
           symptomatizing patients following supracervical hysterectomy, of any age, of any
           complaints. The

        -  Methods: All patients' demographic data, history, indication of hysterectomy, duration
           since operation, postoperative complications and their main complaint.
    

Intervention name(s): Questionanniare
Intervention type(s): Other
Intervention description(s): Filling printed questionnaire + Pelvic examination
Other intervention name(s): Pelvic examination
Observational model: Cohort
Time perspective: Cross-Sectional
Sampling method: Probability Sample
Study population: 
        • Patients: 1280 patients with hysterectomy recruited at Tanta University Hospital,
        gynecology clinics in central hospitals in Gharbia governorate
Clinical Trial to Evaluate CD19 CAR T (CT032) in Patients With Relapsed and/or Refractory Non-Hodgkin's B Cell Lymphoma
Condition: Refractory B-Cell Non-Hodgkin Lymphoma; Relapsed B-cell Non-Hodgkin Lymphoma
MeSH terms: Lymphoma; Lymphoma, Non-Hodgkin; Lymphoma, B-Cell
Study type: Interventional
Phase: Phase 1/Phase 2

Summary: 
      This is an open-label, single arm study to evaluate the safety and tolerability of treatment
      with CT032 CAR-CD19 T in patients with relapsed and/or refractory non-Hodgkin's B cell
      lymphoma (R/R B-NHL).
    

Detailed description: 
      This study is a single-arm, open label, phase I/II clinical trial to evaluate the safety,
      efficacy and cellular kinetics of CT032 CAR-CD19 T cells in patients with R/R B-NHL. The
      study is composed of two stages, Phase I stage is for dose escalation and recommendation of
      phase 2 dose, and Phase II stage is to verify the efficacy and safety of the dose proposed.
    

Intervention name(s): CAR-CD19 T Cells
Intervention type(s): Biological
Intervention description(s): The CAR- CD19 T cells (study drug) used in this study are chimeric antigen receptor specifically expressing T cells targeting CD19.
Fludarabine and Cyclophosphamide are used for lymphodepletion.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Relapsed and/or Refractory B-cell Non-Hodgkin Lymphoma; CAR T