Abdominal Obesity and Cardiovascular Risk Factors in Women Who Survived Cancer or a Related Illness Following Total Body Irradiation and Stem Cell Transplant
Condition: Leukemia; Hodgkin's Lymphoma; Non-Hodgkin's Lymphoma; Myelodysplastic Syndrome
MeSH terms: Lymphoma; Leukemia; Lymphoma, Non-Hodgkin; Preleukemia; Hodgkin Disease; Myelodysplastic Syndromes; Obesity, Abdominal
Study type: Observational

Summary: 
      The purpose of this study is to better understand why some women who survived cancer or a
      related illness later develop diabetes, problems with their cholesterol, or other problems
      that may lead to heart disease. Because these problems may be related to treatment with total
      body irradiation and a stem cell transplant, the investigators will compare the rates of
      obesity, cholesterol problems, and diabetes between women who were treated with total body
      irradiation and a stem cell transplant and women who were not.

      The amount and location of fat stores in the abdomen is more important than overall weight or
      total body fat in the development of diabetes and cholesterol problems. In general, fat can
      be stored in several areas in the abdomen: around the organs (visceral fat), under the skin
      (subcutaneous fat), and in the liver (liver fat). People with higher amounts of fat around
      the organs (visceral fat), even those with a normal weight, are more likely to become
      diabetic or have high cholesterol. The amount of fat in each of these areas can be measured
      with an abdominal magnetic resonance imaging (MRI).

      In this study, the investigators will use blood tests, height, weight, waist circumference,
      blood pressure measurements, and an abdominal MRI to evaluate for several risk factors of
      heart disease, including cholesterol problems, diabetes and pre-diabetes, elevated blood
      pressure, and increased abdominal fat.
    

Detailed description: 
      We will enroll 60 female participants in this study. From the population of interest, female
      cancer survivors (or women treated for a related illness) who were treated with TBI prior to
      a SCT, we will enroll 30 participants, 10 from each of the following cancer groups: acute
      lymphoblastic leukemia, acute myeloid leukemia, and chronic myeloid leukemia. We are
      interested in determining the outcomes in adult survivors who have completed their growth by
      the time of study and yet are younger than the age when most women generally begin to develop
      insulin resistance or dyslipidemia in the general population. For this reason, we will enroll
      women who are 18 - 49 years of age at the time of study.
    

Intervention name(s): Questionnaires, Laboratory tests, Abdominal MRI
Intervention type(s): Other
Intervention description(s): Height, weight, waist and hip circumference; systolic and diastolic blood pressure; questionnaires; fasting blood tests: insulin, glucose, lipids (low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides, LDL pattern, HDL and LDL subspecies), cardiac inflammatory markers (hsCRP, IL-1B, IL-6, IL-10, TNFa), leptin, adiponectin, IGF-1, and IGFBP3; abdominal MRI for visceral and subcutaneous fat measurement
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Potential research subjects will be identified by a member of the research team from the
        SCT database and the medicine and pediatrics leukemia databases.
      
Biospecimen description: 
      whole blood
    
Keywords: leukemia; survivors; women; leukemia survivors; cancer or a related illness; Hodgkin's Lymphoma; Non-Hodgkin's Lymphoma; myelodysplastic syndrome; aplastic anemia; treated with total body irradiation; followed by an allogeneic or autologous stem cell transplant