bioihbjkbjnl/mcl2 huggingface dataset:
Mobilization With Movement Versus Mulligan Knee Taping Technique on Patellofemoral Pain Syndrome.
Condition: Patellofemoral Syndrome
MeSH terms: Patellofemoral Pain Syndrome; Syndrome
Study type: Interventional

Summary: 
      This study intends to determine the effects of MWM verses Mulligan knee taping on
      patellofemoral pain syndrome.
    

Detailed description: 
      This is a single blinded randomized controlled trial, will be conducted at Pakistan railway
      general hospital Rawalpindi. Both MWM and Mulligan knee taping Techniques are used in
      patients with patellofemoral pain syndrome. Sample size of 34 individuals was calculated
      through Open Epi tool version 3 with 95 % confidence interval (CI), and power 80%. 34
      individuals were screened out on the basis of inclusion and exclusion criteria. Individuals
      of this selected population were randomly allocated as 17 individuals in MWM (straight leg
      raise with traction and tibial gliding) group and 17 individuals Mulligan knee taping group
      by sealed envelope method. And after this Both groups will receive conventional therapy.

      Assesment will be done at baseline, 2nd week and after 6 weeks Data will be analyzed on SPSS
      version 21.
    

Intervention name(s): Moblization with Movement; Mulligan knee taping
Intervention type(s): Other; Other
Intervention description(s): patients with group 1 will receive two techniques pertaining to MWM intervention (straight leg raised with traction and tibial Gliding) Repeat it 10 times,3 sets and 1 mint interval. .For Tibial Gliding we will asks the patient to perform 10 repetitive active knee extensions. Practice will be performed by doing 10 reps for 3 sets with 1 min interval. After this home exercises will b guided stretching of hamstrings 8 to 10 reps 20 sec hold, strengthening of Quadriceps and VMO with 10 reps and 3 sets; patient with group 2 will receive Mulligan taping technique. Tape will be applied for two days then we will change it. After this home based exercise will be guided which is stretching of hamstrings 8 to 10 reps 20 sec hold , strengthening of Quadriceps and VMO with 10 reps and 3 sets.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: There will be two groups of participant. One group will receive MWM along with conventional therapy and the second group group will receive Mulligan knee taping along with conventional therapy.
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Anterior Knee Pain Syndrome
Impact of Schemas, Cognitive Emotion Regulation on Quality of Life of HIV Patients: Assessing Outcomes of CBT
Condition: Quality of Life
Study type: Interventional

Summary: 
      The present study has investigated the impact of schemas, cognitive emotion regulation and
      social connectedness on the Quality of life of HIV patients in South Punjab region, Pakistan.
    

Detailed description: 
      The present study has investigated the impact of schemas, cognitive emotion regulation and
      social connectedness on the Quality of life of HIV patients in South Punjab region, Pakistan.
      The main study was conducted in four steps as follows:

      Step 1: Pre-testing, N=150 Baseline assessment Random assignment of willing participants to
      control and experimental Step 2: CBT Intervention, N=40, 20 each group Step 3: post-test Step
      4: Follow up Assessmen
    

Intervention name(s): CaCBT
Intervention type(s): Behavioral
Intervention description(s): Culturally adapted Self help guide and modules total eight 80 hour session per week
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Repeated measures design
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Health Services Research
Effects of Gastric Bypass Surgery on Bile Acid Homeostasis
Condition: Obesity
MeSH terms: Obesity
Study type: Observational

Summary: 
      The purpose of this study is to determine whether the bile acid circulation is changed after
      gastric bypass surgery. Further, to account for how the changed anatomy of the gut influences
      how the bile acid and food is mixed in the gut and how this is associated with the changes in
      gut hormone release after the surgery.

      Our hypothesis is that bile acid reabsorption from the gut is increased as animal models
      suggest so and bile acid blood concentration increases after surgery.
    


Observational model: Case-Control
Time perspective: Cross-Sectional
Sampling method: Non-Probability Sample
Study population: 
        Patients are recruited from the population undergoing gastric bypass surgery at Hvidovre
        Hospital (Denmark) Controls are recruited from www.forsoegsperson.dk (Danish webpage for
        recruitment of trial persons). Controls are recruited by advertisement.
      
Keywords: Roux-en-Y Gastric Bypass Surgery; Bile Acid Circulation; Obesity; Bariatric Surgery
Body Fat Percentage Prediction Model After Basic Combat Training on Army Candidate in Indonesia
Condition: Military Activity
Study type: Interventional

Summary: 
      This research is a quantitative study using the Pre-Experimental Model One-Group
      Pretest-Posttest Design with total sampling from the Republic of Indonesia Defense University
      batch 4 cadets that fullfiled criteria. The intervention is 12 weeks basic combat training
      (only one group), a compulsory program for cadets.
    

Detailed description: 
      the purpose of this study is know the effect of basic combat training on the anthropometry
      and body fat percentage prediction model of army cadets after basic combat training in
      Indonesia
    

Intervention name(s): basic combat training (investigator did not design the intervention)
Intervention type(s): Other
Intervention description(s): 12 weeks basic combat training is 12 weeks is a compulsory program for all cadets accepted in republic indonesia defense university
Intervention model: Single Group Assignment
Intervention model description: Pre-Experimental Model One-Group Pretest-Posttest Design
Masking: None (Open Label)
Primary purpose: Screening
Keywords: Anthropometry; body composition; basic combat training; predictive model formula; military cadets
Novel Mobile Application to Assess Dietary Information
Condition: Dietary Assessment
Study type: Interventional

Summary: 
      The study will assess the accuracy of food capture methods using a novel mobile application.
      This will be done by comparing the energy and nutrient content of reported foods against
      those of foods actually consumed (i.e., reported vs actual). Two methods of using the
      application will be tested:

        1. During each eating occasion to report foods and amounts consumed

        2. By taking photographs of every food consumed, using the camera functionality of the
           mobile application and using the application the following day (according to the
           availability of the study subjects) to report foods and amounts consumed. This is to be
           consistent with the concept of a 24-hour dietary recall.

      One group will use a standard 24-hour dietary recall method.
    


Intervention name(s): subjects will install a mobile app for use
Intervention type(s): Other
Intervention description(s): novel mobile application
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Other
Study of IBI308 With Advanced/Metastatic Esophageal Squamous Cell Carcinoma After Failure of First-line Treatment
Condition: Esophageal Squamous Cell Carcinoma
MeSH terms: Carcinoma; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma
Study type: Interventional
Phase: Phase 2

Summary: 
      Efficacy and safety evaluation of IBI308 versus paclitaxel/irinotecan in patients with
      advanced/metastatic esophageal squamous cell carcinoma after failure of first-line treatment:
      a randomized, open-label, multicenter, phase 2 study
    

Detailed description: 
      Efficacy and safety evaluation of IBI308 versus paclitaxel/irinotecan in patients with
      advanced/metastatic esophageal squamous cell carcinoma after failure of first-line treatment:
      a randomized, open-label, multicenter, phase 2 study (ORIENT-2)
    

Intervention name(s): IBI308; paclitaxel/ irinotecan
Intervention type(s): Biological; Drug
Intervention description(s): IBI308 200mg Intravenous drip every three weeks；; paclitaxel 175mg/㎡ Intravenous drip every three weeks or irinotecan 180mg/㎡ Intravenous drip every two weeks
Intervention MeSH terms: Paclitaxel; Irinotecan
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Oxytocin Effect on Attention Inhibition
Condition: Healthy
Study type: Interventional

Summary: 
      Effects of intranasal oxytocin (24IU) on cognitive control of attention
    

Detailed description: 
      The cognitive control of attention towards neutral and emotional stimuli represents a key
      functional domain and disruptions in this domain have been associated with a range of
      psychiatric disorders. Saccadic eye movement tasks have been used to assess individual
      differences in the cognitive control of attention and alterations in psychiatric disorders.
      Recent evidence suggests that the hypothalamic neuropeptide Oxytocin (OXT) may modulate
      attention allocation and regulation. To this end the present randomized between-subject
      placebo-controlled experiment examined whether intranasal OXT modulates behavior in an
      eye-tracking saccade / anti-saccade paradigm in healthy male subjects. The paradigm used
      non-social (neutral shape) as well as social (happy, sad, angry, fear, and neutral faces)
      stimuli to explore emotion-specific effects of OXT.
    

Intervention name(s): oxytocin treatment; placebo treatment
Intervention type(s): Drug; Drug
Intervention description(s): intranasal administration of oxytocin (24IU); intranasal administration of placebo
Intervention MeSH terms: Oxytocin
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: oxytocin, eye-tracking, attention inhibition
Monoclonal Antibody Therapy in Treating Patients With Follicular or Mantle Cell Lymphoma
Condition: Lymphoma
MeSH terms: Lymphoma; Lymphoma, Mantle-Cell
Study type: Interventional
Phase: Phase 3

Summary: 
      RATIONALE: Monoclonal antibodies such as rituximab can locate cancer cells and either kill
      them or deliver cancer-killing substances to them without harming normal cells. It is not yet
      known which treatment regimen is more effective for lymphoma.

      PURPOSE: Randomized phase III trial to compare the effectiveness of different regimens of
      rituximab in treating patients who have follicular or mantle cell lymphoma.
    

Detailed description: 
      OBJECTIVES:

        -  Assess the clinical efficacy of consolidation treatment with rituximab in terms of
           response rate in patients with follicular (closed to accrual 9/18/00) or mantle cell
           lymphoma.

        -  Compare the event free survival of patients after induction with or without
           consolidation.

        -  Compare the tolerability of these two treatment regimens by these patients.

      OUTLINE: This is a randomized, open label, multicenter study. Patients are stratified
      according to participating center, histology (follicular (closed to accrual 9/18/00) vs
      mantle cell), status of disease (de novo vs relapsed vs resistant), response after induction
      (stable disease vs partial or complete response), and treatment status (treated vs
      untreated).

      All patients receive induction therapy consisting of rituximab IV over 3-5 hours once a week
      during weeks 1-4. Patients are then randomized to one of two treatment arms.

        -  Arm I: Patients are observed.

        -  Arm II: Patients receive rituximab IV over 3-5 hours once a week during weeks 12, 20,
           28, and 36.

      Patients are followed weekly for the first month; every 8 weeks for the next 8 months; then
      at 12, 18, and 24 months; and then annually for the next 3 years.

      PROJECTED ACCRUAL: A total of 240 patients (120 per arm) will be accrued for this study
      within 3-4 years.
    

Intervention name(s): rituximab
Intervention type(s): Biological
Intervention MeSH terms: Rituximab
Allocation: Randomized
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: stage I mantle cell lymphoma; contiguous stage II mantle cell lymphoma; noncontiguous stage II mantle cell lymphoma; stage III mantle cell lymphoma; stage IV mantle cell lymphoma; recurrent mantle cell lymphoma
Prevention of Permanent Obesity in Children
Condition: Overweight; Obesity; Child
MeSH terms: Obesity; Overweight; Pediatric Obesity
Study type: Interventional

Summary: 
      In the county of Oppland, Norway, questionnaires addressing physical and mental health and
      socioeconomic status is issued to all (1960) families who meet for the pre-school assessment
      at the public health clinics in 2007. Particularly growth, physical activity and diet is
      addressed.

      Families who have children with a BMI >18.9, which corresponds to BMI>30, and living in
      selected municipalities in the county are invited to participate in a 5 year intervention
      program in order to avoid future overweight conditions in children. Similarly overweight
      children from the rest of the county serve as controls.
    

Detailed description: 
      Background: Intervention programs to limit or reduce weight in severely obese adults and
      adolescents are rarely successful. In the present study intervention is aimed at moderately
      overweight children of 6 years.

      Families in 7 municipalities who have children with BMI >18.9 are invited to a group-based
      family oriented program involving pediatricians, physiotherapists, dieticians, psychologists
      and nurses with special training. The families are invited to meet in groups times the first
      year, two times the second and one time the third year. According to personal interest the
      families are also invited to meet with the nurse between each of the the above gatherings.

      The children are examined by a pediatrician before entry and after 1, 2, 3 and 5 years with
      specific focus on height and weight. No blood studies are routinely done.

      BMI development will be related to BMIs in the family, mother's weight increase in pregnancy,
      socioeconomic background, general health, psychological factors scored through the Strengths
      And Difficulties Questionnaire, and compliance with the program. Furthermore, the results are
      compared to similarly overweight children from the counties who are not invited to
      participate in the intervention program. The results are obtained through the routine health
      follow-up programs in school.
    

Intervention name(s): parental counseling
Intervention type(s): Behavioral
Intervention description(s): Group-based family oriented program involving pediatricians, physiotherapists, dieticians, psychologists and nurses with special training
Other intervention name(s): Life style counseling
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Prevention
Keywords: overweight; obesity; child
Effects of Age on Amino Acid Delivery to Tendon
Condition: Aging
Study type: Interventional

Summary: 
      Dietary amino acid supplementation may provide an effective means to promote tendon injury
      recovery and enhance collagen synthesis. While most published research has been completed in
      animal models, research with young adults has shown that a leucine-rich whey isolate consumed
      during a chronic resistance training (RT) intervention resulted in greater gains (~60%) in
      tendon CSA when compared to placebo. Leucine-rich diets have also improved tendon collagen
      content in rodents. Further, in our preliminary work utilizing microdialysis, we demonstrate
      that oral consumption of a leucine-rich amino acid beverage increased delivery of amino acids
      to tendons in young adults (21-30 years). However, whether aging alters the delivery of amino
      acids to tendons after oral consumption has not be investigated. In order to optimize amino
      acid dosing for chronic interventional studies, we wish to determine if aging influences
      amino acid concentration in the peritendinous (space around the tendon) space after oral
      consumption.
    


Intervention name(s): Amino Acids
Intervention type(s): Dietary Supplement
Intervention description(s): 10 g bolus of essential amino acids
Allocation: Non-Randomized
Intervention model: Factorial Assignment
Intervention model description: Young (21-30 years old) and older (60-75 years) adults will each receive an oral bolus of 10 g of essential amino acids.
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: amino acid; tendon; aging
New Technologies as a Tool for Health Promotion in Schoolchildren of Compulsory Secondary Education
Condition: Adolescent Behavior; Physical Activity; New Technologies
Study type: Interventional

Summary: 
      The rapid development of new technologies could be one of the causes that has favored changes
      in the lifestyle habits of young people. Research carried out to date shows that new
      technologies could be useful in increasing levels of physical activity and motivation to
      practice sports. However, these studies have major limitations that make it difficult to
      generalize the results.

      The objectives of the present project are: 1) to determine the influence of the use of new
      technologies on the levels of sports practice and the physical and psychological health of
      adolescents; 2) to analyze the effects of a physical-sports activity program that integrates
      new technologies through mobile applications related to physical exercise on the level of
      physical activity and the physical and psychological health of adolescents; and 3) to analyze
      the adherence that this type of program generates in the medium term in adolescents as a
      function of age and gender.

      The project will be divided into two phases. In the first phase, 500 students from the
      centers of Compulsory Secondary Education will be included, who will undergo physical tests,
      questionnaires related to sports practice and physical and psychological health, and an
      anthropometric assessment. In the second phase, an intervention will be carried out with four
      experimental groups and a control group. The four experimental groups will use different
      technological applications outside school hours for 12 weeks. Participants will keep a weekly
      record of physical activity and pre-, post and re-test measurements will be taken to evaluate
      the efficacy of the sports technology applications in increasing and maintaining physical
      activity.
    


Intervention name(s): Sports technology application
Intervention type(s): Behavioral
Intervention description(s): Each of the intervention groups will use in after-school hours a different mobile app for 12 weeks, with a frequency and duration of 60 minutes of training, at least three times a week. A weekly record will be kept by the adolescents in which they will have to indicate the weekly practice frequency, the duration of the activity and the kilometers covered through a report that the adolescents will deliver to the teacher at the end of each week.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Other
Keywords: Adolescents; Physical activity; Psychology; New Technologies
A Longitudinal Study of Hermansky-Pudlak Syndrome Pulmonary Fibrosis
Condition: Hermansky Pudlak Syndrome
MeSH terms: Pulmonary Fibrosis; Hermanski-Pudlak Syndrome; Syndrome
Study type: Observational

Summary: 
      Hermansky-Pudlak Syndrome (HPS) is a rare genetic disease that is associated with
      oculocutaneous albinism, bleeding, granulomatous colitis, and pulmonary fibrosis in some
      subtypes, including HPS-1, HPS-2, and HPS-4. Pulmonary fibrosis causes shortness of breath
      and progressive decline in lung function. In HPS patients with at-risk subtypes, almost all
      adults eventually develop fatal pulmonary fibrosis unless they undergo lung transplantation.

      The purpose of this study is to identify the earliest measurable pulmonary disease activity
      in individuals at-risk for HPS pulmonary fibrosis. The study also aims to develop biomarkers
      that will aid in understanding of the causes of HPS pulmonary fibrosis and facilitate more
      rapid conduct of therapeutic trials in HPS patients with mild pulmonary disease in the
      future.
    


Intervention name(s): Pulmonary function test; Chest CT; Sample collection
Intervention type(s): Other; Other; Other
Intervention description(s): Pulmonary function testing performed; Chest CT scan to evaluate for pulmonary fibrosis; Blood and urine sample collections
Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Individuals with diagnosis of Hermansky-Pudlak Syndrome
      
Biospecimen description: 
      blood, urine, lymphocytes