bioihbjkbjnl/mcl2 huggingface dataset:
dTMS in Obsessive Compulsive Disorder
Condition: Obsessive-Compulsive Disorder
MeSH terms: Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Study type: Interventional

Summary: 
      High-frequency deep transcranial magnetic stimulation (dTMS) over the medial prefrontal
      cortex (mPFC) and the anterior cingulate cortex (ACC) with an H-coil has been approved by the
      Food and Drug Administration for use in treatment-resistant obsessive-compulsive disorder
      (OCD). However, there is not yet strong scientific evidence concerning the efficacy and
      safety of performing a similar procedure with a double-cone coil or in an accelerated manner.
      The aim of this study was evaluating the efficacy of dTMS over the medial prefrontal cortex
      (mPFC) and the anterior cingulate cortex (ACC) in an accelerated manner with double-cone
      coil.
    

Detailed description: 
      The current study aimed to investigate the efficacy and safety of multiple deep stimulations
      per day with a double-cone coil to the mPFC and ACC in treatment-resistant patients with OCD.
      This study evaluated (I) the effectiveness of high-frequency stimulation of the mPFC and ACC
      with a double cone coil, and (II) the effectiveness of the application of this protocol in
      three weeks, not six weeks as approved by the FDA. The participants were randomized into two
      parallel groups in a double-blind manner. High frequency (20 Hz) dTMS was applied to the mPFC
      and ACC in one group and sham dTMS to the same regions in the other group, twice a day, for a
      total of 30 sessions. This application was for three weeks in total, excluding weekends.
    

Intervention name(s): deep TMS; Sham TMS
Intervention type(s): Device; Device
Intervention description(s): Deep Transcranial magnetic stimulation on anterior Cingulate cortex and medial prefrontal cortex. 20 Hz.; Sham Transcranial magnetic stimulation on anterior Cingulate cortex and medial prefrontal cortex. 20 Hz.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: obsessive compulsive disorder; Transcranial Magnetic Stimulation
A Study to Evaluate the Effect of LY2189265 on the Speed at Which Food and Drink Leaves the Stomach in Patients With Type 2 Diabetes Mellitus
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 1

Summary: 
      The primary purpose of this Study is to help answer the following research question(s).

        -  How does LY2189265 affect gastric emptying (the speed at which food and drink leaves the
           stomach) in patients with Type 2 diabetes?

        -  How does LY2189265 affect how the body handles metformin (a drug used to treat Type 2
           diabetes)?

        -  Is LY2189265 safe and are any side effects associated with it?

      The study will be participant-blind in Week 1, and participant- and investigator-blind from
      Week 2 through Week 5.

      Each participant will receive placebo on Week 1 and once-weekly doses of LY2189265 or Placebo
      on Weeks 2 to 5. Participants taking metformin for the treatment of Type 2 Diabetes Mellitus
      (T2DM) will continue taking metformin as part of the study.
    


Intervention name(s): LY2189265; Placebo
Intervention type(s): Biological; Drug
Intervention description(s): 1.5 mg administered subcutaneously; Administered subcutaneously
Intervention MeSH terms: Dulaglutide
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Pharmacokinetic Test of High-fat Diet After Oral Administration of SHR2554 in Healthy Subjects
Condition: Malignant Tumor
MeSH terms: Neoplasms
Study type: Interventional
Phase: Phase 1

Summary: 
      The objective of the study is to assess the effect of food on the pharmacokinetics, and
      safety of SHR2554 Tablets in healthy subjects.
    


Intervention name(s): SHR2554; SHR2554
Intervention type(s): Drug; Drug
Intervention description(s): On an empty stomach - after meals; After meals - on an empty stomach
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Randomized, open-label, single-dose, two-cycle, two-sequence, cross-controlled
Masking: None (Open Label)
Primary purpose: Treatment
Safety and Immunogenicity Study of the Hepatitis B Virus (HBV) Vaccine, HEPLISAV Compared to Engerix-B Vaccine
Condition: Healthy
MeSH terms: Hepatitis B
Study type: Interventional
Phase: Phase 3

Summary: 
      The purpose of the study is to evaluate the safety, immunogenicity and lot-to-lot consistency
      of an investigational hepatitis B virus vaccine, HEPLISAV™, in healthy adults 40 to 70 years
      of age
    

Detailed description: 
      The purpose of the study is to evaluate the safety, immunogenicity and lot-to-lot consistency
      of an investigational hepatitis B virus vaccine, HEPLISAV™, in healthy adults 40 to 70 years
      of age
    

Intervention name(s): HEPLISAV and/or Placebo; Engerix-B
Intervention type(s): Biological; Biological
Intervention description(s): Intramuscular (IM) injections on Week 0 and Week 4; placebo (saline) injection at Week 24; Intramuscular (IM) injections on Week 0, Week 4 and Week 24
Other intervention name(s): Hepatitis B vaccine (recombinant), adjuvanted; Hepatitis B vaccine (recombinant)
Intervention MeSH terms: Vaccines
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Prevention
Keywords: HBV vaccine; Hepatitis B vaccine; Hepatitis B; Hepatitis; HBV; Prevention & Control; Healthy; Healthy volunteers
Mechanical Ventilation With and Without Postural Drainage in Burn Patients With ARDS
Condition: Burns (Physical Finding)
MeSH terms: Respiratory Distress Syndrome; Burns
Study type: Interventional

Summary: 
      Inhalation injury become a more common cause of death in burn patients but alone the smoke
      injury has low mortality rate. It is reported that a combination of smoke injury with
      cutaneous burn increases the mortality rate and predispose to Acute Respiratory Distress
      Syndrome. This experimental study aims to report the benefits of postural drainage on the
      respiratory system in burn patients. This study will determine the effects of postural
      drainage on oxygen saturation, airway clearance in burn patients with Acute Respiratory
      Distress Syndrome by comparing mechanical ventilation with and without the application of
      postural drainage. A randomized clinical trial will be conducted in the data and will be
      collected from the ICU of Jinnah Burn & Reconstructive Surgery Centre and Shafique Aziz Free
      Burn Centre through consecutive sampling through technique on 50 patients which will be
      allocated through sealed opaque enveloped into Group A and Group B. Pre and post treatment
      value of oxygenation and other variables for both group will be recorded by using APACHE II.
      Group A will be treated by postural drainage and mechanical ventilation for two consecutive
      days. Similarly, Group B will be treated by mechanical ventilation only. Data will be
      analyzed using SPSS software 25. After assessing the normality of data by the Shapiro-Wilk
      test, it will be decided either parametric or non-parametric tests will be used within a
      group or between two groups.
    


Intervention name(s): Mechanical Ventilation; Mechanical Ventilation with Postural drainage
Intervention type(s): Other; Other
Intervention description(s): Standard Protocol; This Group will be treated by postural drainage and mechanical ventilation for two consecutive days
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Treatment
Keywords: Respiration; Artifical Respiration; Postural drainage; Respiratory distress syndrome; Respiratory physiological phenomena
Effect of Long-term, High-dose N-acetylcysteine on Exacerbations of Bronchiectaisis
Condition: Non-Cystic Fibrosis Bronchiectasis
MeSH terms: Bronchiectasis
Study type: Interventional

Summary: 
      Objective: To evaluate whether long-term oral N-acetylcysteine as an expectorant drug can
      reduce the frequency of acute exacerbations of patients with non-cystic fibrosis
      bronchiectasis and improve their quality of life.

      Methods: Patients with non-cystic fibrosis bronchiectasis will be randomly assigned to the
      observer group (participants receive 600 mg of oral N-acetylcysteine BID for 12 months) or
      the control group (participants receive oral tablet BID for 12 months). The primary endpoint
      was the frequency of acute exacerbations.

      Expected results: Compared with the control group, the frequency of acute exacerbations of
      the observer Group will decrease significantly.

      Hypothesis: Long-term oral N-acetylcysteine can reduce the frequency of acute exacerbations
      of patients with non-cystic fibrosis bronchiectasis and improve their quality of life.
    

Detailed description: 
      Objective: N-acetylcysteine is a classic mucolytic agent. This study aimed to investigate the
      efficacy and safety of N-acetylcysteine on the risk of exacerbations in bronchiectasis
      patients.

      Methods: A prospective, randomized, controlled trial was conducted between April 1, 2014 and
      December 31, 2016 in five general hospitals in Shandong Province, China. Adult bronchiectasis
      patients with at last two exacerbations in the past year were potentially eligible. Patients
      were randomly assigned to receive oral N-acetylcysteine (600 mg, twice daily, 12 months) or
      on-demand treatment.

      Results: A total of 161 patients were eligible for randomization (81 to the N-acetylcysteine
      group and 80 to the control group). During the 12-month follow-up, the incidence of
      exacerbations in the N-acetylcysteine group was significantly lower than that in the control
      group (1.31 vs. 1.98 exacerbations per patient-year; risk ratio, 0.41; 95% CI, 0.17-0.66; P =
      0.0011). The median number of exacerbations in the N-acetylcysteine group was 1 (0.5-2),
      compared with 2 (1-2) in the control group (U=-2.95, P = 0.003). No severe adverse events
      were reported in the intervention group.

      Conclusion: The long-term use of N-acetylcysteine is able to reduce the risk of exacerbations
      for bronchiectasis patients.
    

Intervention name(s): N-acetylcysteine; On-demand treatment
Intervention type(s): Drug; Other
Intervention description(s): 600mg po twice a day for 12 months; receive as-needed therapy
Intervention MeSH terms: Acetylcysteine; N-monoacetylcystine
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: N-acetylcysteine；; Bronchiectasis；; Acute exacerbations；; Antioxidant；; Anti-inflammatory
Pediatric Alliance for International Neurogastrointestinal Functional Research
Condition: Irritable Bowel Syndrome
MeSH terms: Irritable Bowel Syndrome
Study type: Observational

Summary: 
      To explore the predictive value of alarm signs ("red flags") for a diagnosis of functional
      gastrointestinal disorders (FGID) in children.

      To assess the natural history of pain predominant functional gastrointestinal disorders
      (FGID) in newly diagnosed pediatric patients.

      To document the benefit of various treatment regimens currently employed in managing FGID.

      To assess the short- and long-term impact of various FGID regimens.

      To allow physicians to gain a better understanding of the epidemiology of FGID.

      Hypothesis:

      There are presenting symptoms or results from diagnostic tests that are more likely to
      associated with conditions different from FAP or IBS.

      Symptoms of children with FAP/IBS change overtime regardless of the treatments used.
    


Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients ages 4 through 16 years of age (up to the day of the 17th birthday) will be
        recruited from the Nationwide Children's Hospital Gastrointestinal Department that are
        presenting with chronic or intermittent abdominal pain of any severity lasting at least 2
        months.
Effects of a Combination of Polyphenol-rich Extracts on the Protection of Retinal Cells Against Blue Light in the Prevention of Ocular Diseases
Condition: Eye Abnormalities
MeSH terms: Eye Abnormalities
Study type: Interventional

Summary: 
      The aim of the study is to confirm that daily supplementation with a product containing a
      standardized combination of polyphenol-rich extracts has a protective effect against
      potential blue-light-induced damage to retinal cells.
    

Detailed description: 
      Randomized, double-blind, parallel study conducted under medical supervision on a group of 54
      volunteers exposed to blue-light for 6-8h a day. Patients receive one of the investigational
      products or placebo for 6 weeks. Study parameters: OCT (optical coherence tomography), Amsler
      test, Computerized Perimetry, Schirmer test. In addition, subjective symptoms will be
      assessed using the Visual Analog Scale (VAS) method and a Dry Eye-Related Quality-of-Life
      Questionnaire. The studied parameters will be measured before and after supplementation.
    

Intervention name(s): Complex product; Polyphenol-rich extracts; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement; Other
Intervention description(s): Extracts from the fruits of Vaccinium myrtillus L. + Aronia Melanocarpa (Michx.) Elliot + Lonicera caerulea var. Kamtschatica, rutin, vitamin B6, vitamin B12, folic acid Single oral dose - 2 capsules; Extracts from the fruits of Vaccinium myrtillus L. + Aronia Melanocarpa (Michx.) Elliot + Lonicera caerulea var. Kamtschatica Single oral dose - 2 capsules; Single oral dose - 2 capsules
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Supportive Care
Keywords: Retinal cells; Ocular diseases; Blue-light
Exoskeleton and Spinal Cord Injury
Condition: Spinal Cord Injuries
MeSH terms: Spinal Cord Injuries; Wounds and Injuries
Study type: Interventional
Phase: Phase 2

Summary: 
      The purpose of the current study is to investigate the effects of powered exoskeleton (EKSO)
      on cardiovascular performance as measured by resting blood pressure and heart rate, peak
      oxygen consumption during walking, energy expenditure, whole and regional body composition
      assessments. The effects of exoskeleton training on walking kinematics including stand-up
      time, walking time, distance covered and speed of walking will also be evaluated.
    

Detailed description: 
      Powered exoskeletons using robotic suits have recently been introduced for the rehabilitation
      of persons with spinal cord injury (SCI). Exoskeletons offer a unique opportunity for persons
      with SCI to experience standing and walking at a low metabolic cost. Evidence suggested that
      exoskeleton assisted walking can decrease spasticity and improve bowel movement. Training may
      also improve the level of physical activity as well as psychological parameters that are
      likely to interfere with rehabilitation outcomes. Previous studies reported that a frequency
      of 2-3 times per week or more for 1-2 hours may be beneficial in the rehabilitation of
      persons with SCI. Using exoskeletal-assisted walking to improve the level of physical
      activity may be appealing to persons with SCI.

      Exoskeleton training for 12 weeks may enhance energy expenditure, parameters of physical
      activity and result only on modest effects on both cardiovascular and body composition
      parameters. In other words, persons with tetraplegia may have greater cardiovascular and body
      composition adaptations compared to persons with paraplegia. Twenty subjects will participate
      in a powered exoskeleton (EKSO) for one or twice a week for 12 weeks. The program will
      involve walking with the robotic suits for 1 hour for persons with complete (n=10) and
      persons with incomplete (n=10) SCI.
    

Intervention name(s): Exoskeleton Training
Intervention type(s): Device
Intervention description(s): Twenty subjects will participate in a powered exoskeleton (EKSO) for one or twice a week for 12 weeks. The program will involve walking with the robotic suits for 1 hour for persons with complete (n=10) and persons with incomplete (n=10).
Intervention model: Single Group Assignment
Intervention model description: Twenty subjects will participate in a powered exoskeleton (EKSO) for one or twice a week for 12 weeks. The program will involve walking with the robotic suits for 1 hour for persons with complete (n=10) and persons with incomplete (n=10) SCI.
Masking: None (Open Label)
Primary purpose: Treatment
Bed Rest or no Bed Rest?
Condition: In Vitro Fertilization
Study type: Interventional

Summary: 
      A comparative study to determine whether bed rest after embryo transfer (ET) affects on IVF
      (In Vitro Fertilization)outcome. This study includes 240 patients undergoing IVF treatment
      with donated oocytes. All the procedures of IVF, of the embryo transfer, and of the
      administration of medications are performed as always and there are no variations. The only
      highlighted procedure in this study is immediately after the embryo transfer. There are two
      groups: one which will rest in bed for 10 minutes after the transfer and one which will not
      rest after the transfer. Both procedures are common, usually depending on the habitual
      clinical practice of each clinic internationally. Patients from both group receive the
      routine post transfer instructions and treatment.
    


Intervention name(s): Bed rest; No bedrest
Intervention type(s): Behavioral; Behavioral
Intervention description(s): Patients will rest in bed ten minutes after the embryo transfer.; Patients will not rest in bed after the embryo transfer.
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Supportive Care
Keywords: Embryo transfer; Implantation rate; Pregnancy rate; bedrest; neutral; benevolent; deterious; implantation; gestation rates
Dry Needling and Maitland Joint Mobilization Techniques in Patients With Myofacial Chronic Neck Pain
Condition: Myofacial Pain; Neck Pain
MeSH terms: Neck Pain; Facial Pain
Study type: Interventional

Summary: 
      The purpose of my research is to compare the effects of dry needling and Maitland
      mobilization in chronic myofacial neck pain
    

Detailed description: 
      To distinguish which technique is most effective in pain reduction and range gain because in
      chronic cases there is involvement of fascia, muscles and joints due to prolonged stress on
      any of the component affecting the other. Hence, the study will help to design a treatment
      plan with more accurate intervention. After sample collection according to selection criteria
      treatment sessions will be given to both groups for 6 weeks. Data will be collected at
      baseline, then after 2 weeks, 4 weeks and at 8th week. Tools for data collection are Visual
      analogue scale, Neck Disability Index and Goniometer. For statistical analysis SPSS 22 will
      be used. Intra group difference will be calculated by repeated measurement ANOVA / Friedman
      test and inter group analysis will be done by Independent sample t test. Descriptive data
      will be expressed in terms of frequency and proportions.
    

Intervention name(s): Dry Needling; Maitland Mobilization
Intervention type(s): Other; Other
Intervention description(s): TENS 10 minutes, Stretching, Strengthening(girdle),Neck Isometrics, DN; TENS 10 minutes, Stretching, Strengthening(girdle),Neck Isometrics, Maitland joint mobilization
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Neck Pain; Myofacial Pain
Functional Residual Capacity Measured by Capnography in Ventilated Patients
Condition: Respiratory Physiological Phenomena
Study type: Observational

Summary: 
      Changes in body position during anesthesia can alter functional residual capacity and gas
      exchange. The monitoring of such changes in functional residual capacity is difficult at the
      bedside. The present study was designed to determine if volumetric capnography can detect
      changes in the functional residual capacity during surgery.
    

Detailed description: 
      This is a prospective and observational study designed to test the reliability of the
      capnodynamic equation to determine changes in functional residual capacity measured during
      anesthesia. The investigators will studied 40 mechanically ventilated patients undergoing
      general anesthesia. Functional residual capacity will be continuously measured in a non
      invasive way using expired carbon dioxide. Changes in functional residual capacity with
      standard modification in body positioning (Trendelenburg or anti-Trendelenburg position) and
      ventilatory settings wiil be tested.
    

Observational model: Case-Only
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Patients undergoing general anesthesia for laparoscopic surgery
Gender Dependent Difference in Lipemia After 6 x OFTT in Young Healthy Subjects
Condition: Hyperlipidemia
MeSH terms: Hyperlipidemias
Study type: Interventional

Summary: 
      The investigators wanted to study the postprandial lipemia after six oral fat tolerance test
      with varying amounts of saturated fat in young healthy subjects.
    

Detailed description: 
      With six different types of butter added in random order to potatoes the investigators
      studied postprandial lipemia (PPL), lipoprotein, glucose, and insulin increments for eight
      hours in 14 young, lean, healthy students, seven of each gender.

      The six, isocaloric meals contained 55.1 g carbohydrate, 5.8 g protein, 82.3 g fat, and 4177
      kJ. The potatoes, without skin, were boiled in 20 minutes in excess of water with 5 g of salt
      added, were blended in 4 minutes and served hot. The meals were ingested over 10 minutes,
      with 250 ml tap water. The following 8 hours the participants stayed at the clinic to watch
      television, read or take a short walk of 10 minutes.

      Blood samples were drawn at -15, 0, 30, 60, 90,120,180,240,300,360, 420 and 480 minutes after
      the meals and processed after each drawing. After blood collection, plasma was immediately
      separated by centrifugation at 3000 rpm for 10 minutes at 4°C.

      The area under the curve (AUC) were determined for TG, HDL, LDL, total cholesterol, FFA,
      insulin, and glucose concentrations by the trapezoid method. Multiple regression was
      performed to adjust for age, gender, meals, and BMI to the variance of postprandial
      responses. The difference between meals were tested with ANOVA. If p<0.05 in ANOVA,
      post-hoc-testing with Student-Newman-Keul's test was performed to identify, which meal was
      significantly different from the other, and to minimize the risk of error by multiple
      testing.
    

Intervention name(s): Six different types of fat in a meal in random order
Intervention type(s): Dietary Supplement
Intervention description(s): Oral fat tolerance test
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Basic Science
Keywords: Postprandial lipemia; glycemic response