The Effect of Milk Protein vs Blends of Milk and Plant Protein on Growth Markers in 7-8 Year Old Healthy Danish Children
Condition: Growth Acceleration; Growth; Stunting, Nutritional
MeSH terms: Growth Disorders
Study type: Interventional

Summary: 
      The purpose of PROGRO is to determine which combinations of milk and plant proteins are
      optimal to promote growth factors in children
    

Detailed description: 
      The main objective is to assess how different protein blends affect growth factors in
      children. There is evidence to support that milk protein increases growth in children in both
      high and low-income countries. Therefore milk protein is often used in food aid for
      undernourished children in low-income countries. The study investigates if plant protein can
      partially replace milk protein without affecting growth promotion negatively. Plant protein
      could potentially reduce food aid costs and at the same time be a more sustainable protein
      source.

      The PROGRO study is a 3-arm randomized, controlled trial. The effect of consuming 35 g pure
      milk protein/day is compared to intake of 35 g milk and rapeseed protein/day (ratio 30:70 and
      54:46, respectively) in 7-8 year old healthy Danish children. The intervention period is 4
      weeks and measurements and blood sampling are performed at baseline, week 1 and week 4. A
      3-day weighed dietary intake is recorded before each visit. The primary outcome is
      Insulin-like growth factor-1 (IGF-1).
    

Intervention name(s): 35 g protein (30% milk + 70% rapeseed); 35 g protein (54% milk + 46% rapeseed); 35 g protein (100% milk)
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): The daily amount of 35 g of protein is provided as a powder. The powder is packed in two separate sachets to be consumed in the morning and evening. Each sachet contains approximately 60 g of powder. The powder is mixed with liquid before intake.
Protein powder ingredients (all are food quality):
Milk protein: Skimmed milk powder (Arla Foods, Viby, Denmark)
Rapeseed protein isolate: Isolexx® (BioExx, Saskatoon, Canada)
Other ingredients: lactose, sucrose, flavors, artificial sweeteners. The protein powders for each treatment group are standardized to contain the same amount of energy and lactose per day.; The daily amount of 35 g of protein is provided as a powder. The powder is packed in two separate sachets to be consumed in the morning and evening. Each sachet contains approximately 60 g of powder. The powder is mixed with liquid before intake.
Protein powder ingredients (all are food quality):
Milk protein: Skimmed milk powder (Arla Foods, Viby, Denmark)
Rapeseed protein isolate: Isolexx® (BioExx, Saskatoon, Canada)
Other ingredients: lactose, sucrose, flavors, artificial sweeteners. The protein powders for each treatment group are standardized to contain the same amount of energy and lactose per day.; The daily amount of 35 g of protein is provided as a powder. The powder is packed in two separate sachets to be consumed in the morning and evening. Each sachet contains approximately 60 g of powder. The powder is mixed with liquid before intake.
Protein powder ingredients (all are food quality):
Milk protein: Skimmed milk powder (Arla Foods, Viby, Denmark)
Other ingredients: lactose, sucrose, flavors, artificial sweeteners. The protein powders for each treatment group are standardized to contain the same amount of energy and lactose per day.
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: The study is a randomized, controlled, double-blind, parallel food intervention study with 3 study arms
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Basic Science
Keywords: Growth factor; Protein; Milk protein; Plant protein; Insulin-like growth factor-1 (IGF-1); Insulin; Insulin-like growth factor-binding protein-3 (IGFBP-3)