bioihbjkbjnl/mcl2 huggingface dataset:
A Long-Term Examination of Asthma From Childhood Through Adolescence
Condition: Asthma; Dermatitis, Atopic; Rhinitis; Urticaria
MeSH terms: Rhinitis; Asthma; Dermatitis, Atopic; Dermatitis; Urticaria
Study type: Observational

Summary: 
      Asthma is a common disease that is often diagnosed in childhood. In some teenagers, asthma
      symptoms disappear and treatment can be stopped; however, for some of these people, asthma
      symptoms return in adulthood. This study will examine data collected over the lifetime of
      18-year olds to identify factors that may increase a person's chance of having recurrent
      asthma as an adult.
    

Detailed description: 
      Asthma is a serious, long-term illness that affects around 15% of children in the United
      States. During adolescence, up to 50% of teenagers stop experiencing symptoms and are able to
      discontinue treatment. However, asthma symptoms often reoccur in adulthood for many of these
      people. It is not known exactly what causes this recurrence, but potential risk factors may
      include obesity, elevated serum leptin levels, early onset of puberty, exposure to
      pollutants, parental smoking habits, and lack of breastfeeding. Additionally, it is not known
      why childhood asthma is initially more prevalent in boys, but during adolescence it becomes
      more prevalent in girls. Beginning in 1989, a group of children born on the Isle of Wight in
      the United Kingdom has been followed by study researchers to provide long-term information on
      asthma. These children have been periodically evaluated over the years and are now 18 years
      old. The purpose of this study is to analyze participants' data collected over a span of 18
      years to identify factors that may increase a person's risk of experiencing persistent or
      recurrent asthma in adulthood.

      At previous study visits that occurred when participants were 1, 2, 4, and 10 years old,
      information on the following was collected: asthma and other allergic diseases, family
      history of asthma, and early life risk factors, including breastfeeding and tobacco smoke
      exposure. A blood sample was collected at participants' 10-year study visit. For this current
      study, all 18-year-old participants will return for a study visit. Participants will complete
      questionnaires on asthma and allergy symptoms and environmental exposures, including tobacco
      smoke and pollution. Blood collection, an allergy skin prick test, lung function testing, and
      a bronchial challenge test to assess airway function will occur. Select participants will
      also have a sputum sample collected.
    

Observational model: Cohort
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        The study population consists of around 1500 unselected subjects (now age 18) who were
        recruited at birth. This is a homogenous population with 99% being Caucasians.
      
Biospecimen description: 
      Whole blood, serum, saliva, urine
    
Keywords: Bronchial Asthma; Food Allergy; Bronchial Hyperresponsiveness
Early Use of Rosuvastatin in Acute Coronary Syndromes: Targeting Platelet-Leukocyte Interactions
Condition: Acute Coronary Syndrome; Angioplasty, Transluminal, Percutaneous Coronary; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Blood Platelets
MeSH terms: Acute Coronary Syndrome; Syndrome
Study type: Interventional
Phase: Phase 1

Summary: 
      The central hypothesis for this work is that platelet - leukocyte interactions play a
      critical role in the pathogenesis of acute ischemic events. The primary objective of the
      study is to determine if early, high-dose administration of the HMG-CoA reductase inhibitor
      rosuvastatin in the setting of acute coronary syndrome and percutaneous coronary intervention
      exerts beneficial vascular effects by reducing platelet - leukocyte interactions.
    


Intervention name(s): rosuvastatin; placebo
Intervention type(s): Drug; Drug
Intervention description(s): Patients (n = 54) presenting acute coronary syndrome/non-ST elevation myocardial infarction who present within 8 hours of symptom-onset will be randomized to two groups to receive rosuvastatin (40 mg oral dose) or placebo at the time of presentation, in addition to standard of care (aspirin, clopidogrel, low molecular weight heparin). Blood will be collected at baseline (time of enrollment, immediately prior to drug or placebo), at 6 - 8 hours, at 18 - 24 hours, and at 30 days for analysis of platelet - leukocyte co-aggregate formation, biomarkers of platelet - leukocyte interactions, and biomarkers of myocardial necrosis. Additional samples may be collected just after revascularization, in patients undergoing PCI. The group of patients treated with rosuvastatin will be maintained on rosuvastatin 20 mg daily and the group randomized to placebo will be given rosuvastatin (20 mg oral once daily) within 48 hoursof enrollment and after planned PCI, but before hospital discharge.; frequency and duration
Other intervention name(s): crestor
Intervention MeSH terms: Rosuvastatin Calcium
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: Platelet activation; platelet leukocyte aggregates
Botanical Supplement Muscle Function and Lean Body Mass
Condition: Healthy Volunteers
Study type: Interventional

Summary: 
      Purpose: To evaluate the acute and chronic effects of a botanical supplement on strength,
      muscle function, and lean body mass

      Participants: The acute phase will include 30 participants, and the chronic phase will
      include 84 participants. All participants must be healthy recreationally active males between
      the ages of 18 and 35 years.

      Procedures (methods):

      Acute phase: Participants will complete three testing visits as part of as part of a
      cross-over design, during which strength and muscle function will be assessed prior to and
      following consumption of a supplement. The experimental supplement is a blend of the
      botanical extracts; treatment arms will include a full dose (FULL; 350 mg capsule), half dose
      (HALF; 175 mg plus maltodextrin), or placebo (PLA; maltodextrin).

      Chronic phase: Body composition, muscle cross-sectional area, a complete blood count and
      metabolic panel, subjective surveys, and strength will be measured prior to and following an
      8-week supervised resistance training program, in conjunction with daily supplementation of
      FULL, HALF, or PLA.
    


Intervention name(s): CS16-003 Full dose; CS16-003 Half dose; Placebo
Intervention type(s): Dietary Supplement; Dietary Supplement; Dietary Supplement
Intervention description(s): 350 mg 'Rhodiola rosea L. & Rhaptonticum carthamoides extracts; 175 mg 'Rhodiola rosea L. & Rhaptonticum carthamoides extracts + maltodextrin 175 mg; Maltodextrin: 350 mg
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary purpose: Other
Keywords: Botanical Supplement; Performance-Enhancing Supplement
A 12-Week Study To Assess The Safety Of Fluticasone Propionate/Salmeterol 100/50 Hydrofluoroalkane (HFA) Versus Fluticasone Propionate 100 HFA In Children With Asthma
Condition: Asthma
MeSH terms: Asthma
Study type: Interventional
Phase: Phase 3

Summary: 
      This study is to assess the safety of an investigational drug in children 4 to 11 years of
      age who have asthma. The subjects will attend 7 clinic visits, of which up to 3 will be in
      the morning, and have lung function tests performed.
    


Intervention name(s): fluticasone propionate; fluticasone propionate/salmeterol
Intervention type(s): Drug; Drug
Intervention description(s): fluticasone propionate 100mcg HFA; fluticasone propionate/salmeterol 100/50mcg HFA
Intervention MeSH terms: Fluticasone; Xhance; Salmeterol Xinafoate
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
Keywords: asthma; fluticasone propionate; children; fluticasone propionate/salmeterol
The Effect of Atorvastatin on Androgens, Glucose Metabolism and Inflammation in Polycystic Ovary Syndrome (PCOS) Women
Condition: Polycystic Ovary Syndrome
MeSH terms: Polycystic Ovary Syndrome; Syndrome; Inflammation
Study type: Interventional

Summary: 
      This is a placebo controlled trial investigating the effect of 6 months atorvastatin 20mg/day
      therapy on androgens, glucose metabolism and inflammatory markers in women with PCOS.

      We assume that during 6 months atorvastatin therapy a significant improvement in
      hyperandrogenism, glucose metabolism and inflammatory markers is observed.
    

Detailed description: 
      30 women diagnosed for PCOS (aged 30-50 years) are enrolled for the study. 15 women are
      randomized in the atorvastatin group and 15 in the placebo group. The women with PCOS
      participating in the study are required to use safe non-hormonal contraception during the
      medication.

      The study includes transvaginal ultrasonography, serum samples, oral glucose tolerance test
      (OGTT) and intra venous tolerance test (IVGTT) before and after receiving 6 months
      atorvastatin 20mg/day therapy or placebo.

      Measurements for androgen levels, pituitary hormones, glucose, insulin and inflammatory
      markers are performed.
    

Intervention name(s): Atorvastatin; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Atorvastatin 20mg/day for 6 months; Placebo for 6 months
Other intervention name(s): Lipitor 20mg, Pfizer
Intervention MeSH terms: Atorvastatin
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: PCOS; Atorvastatin; Androgens; Glucose metabolism; Inflammatory markers
The Effect of Brimonidine
Condition: Intraocular Pressure
Study type: Interventional
Phase: Phase 4

Summary: 
      This study will evaluate whether pre-treating patients with Brimonidine 0.2% before and/or
      after dilating the pupils will help to control the changes in intraocular pressure often seen
      when using dilating drops. The study will also evaluate the effects of different sequences of
      administering dilating drops along with Brimonidine on pupil size and reactivity.
    

Detailed description: 
      Intraocular pressure (IOP) can fluctuate due to various external factors such as exercise,
      medications, and eye movements. Although it is considered natural for IOP to fluctuate daily,
      prolonged increases in IOP can be harmful. Sustained elevated IOP has been linked to optic
      nerve damage and glaucoma. Mydriatic drops routinely given to dilate pupils in patients in
      need of an eye exam have been known to increase IOP. In practice, a combination of drugs are
      used to achieve pupil dilation needed for routine eye exams or in perioperative situations.
      The use of Tropicamide 1% and Phenylephrine 2.5% are known to be safe and effective options
      for dilating the pupils when used in conjunction with one another, but these drugs can
      increase IOP. Drugs such as Brimonidine, a selective alpha-2 agonist, are known to reduce IOP
      through several different methods. This study seeks to understand the effects of Brimonidine
      used along with Tropicamide and Phenylephrine to control IOP.
    

Intervention name(s): Brimonidine; Tropicamide; Phenylephrine Ophthalmic Product
Intervention type(s): Drug; Drug; Drug
Intervention description(s): 2 drops administered once in the left eye in both study arms; 1 drop administered at two different times points in both eyes in both study arms; 1 drop administered at two different time points in both eyes in both study arms
Other intervention name(s): Alphagan; Mirvaso; Mydriacyl
Intervention MeSH terms: Brimonidine Tartrate; Phenylephrine; Oxymetazoline; Tropicamide
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Prevention
Keywords: Brimonidine; Pupil Effects
Effects of Biphasic Insulin Aspart 70/30 vs. Exenatide in Type 2 Diabetes Patients Not Reaching Blood Glucose Targets on Metformin and a Sulfonylurea.
Condition: Diabetes; Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Study type: Interventional
Phase: Phase 3

Summary: 
      This trial is conducted in the United States of America (USA). The study will compare A1C
      reduction achieved in patients receiving biphasic insulin aspart 70/30 once or twice daily to
      patients receiving exenatide twice daily. Patients enrolled in the study will be insulin
      naive patients who have not achieved glycemic control with metformin and sulfonylurea.
    


Intervention name(s): biphasic insulin aspart; exenatide
Intervention type(s): Drug; Drug
Intervention MeSH terms: Insulin Aspart; Exenatide; Biphasic Insulins
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
A Comparative Study Between Postextubation of Preterm Infants Into High-Flow Nasal Cannulae V.S Nasal Continuous Positive Airway Pressure
Condition: Neonatal Respiratory Distress
MeSH terms: Respiratory Distress Syndrome, Newborn; Respiratory Distress Syndrome
Study type: Observational

Summary: 
      The investigators hypothesize that there is a growing trend of the feasibility of HFNC as an
      alternative to other forms of non-invasive ventilation mechanism to provide continuous
      distending pressure to preterm infants. However, there remains uncertainty about the efficacy
      and safety of HFNC in this population.
    

Detailed description: 
      Our primary outcome is to determine whether postextubation respiratory support via heated
      humidified high-flow nasal cannula results in a greater proportion of infants younger than 34
      weeks gestation being successfully extubated after a period of endotracheal positive pressure
      ventilation compared with conventional (NCPAP).

      The following study will be conducted in the neonatal intensive care unit (NICU) of
      Gynecology and Obstetric department of Kasr El Aini hospital and neonatal intensive care unit
      of Military Hospital throughout a time interval of at least 6 months for a minimum of 100
      preterm infants.

      Infants will be eligible for the study if they born at less than 34 weeks' gestation,
      required endotracheal intubation and positive pressure ventilation, and considered ready for
      extubation by the clinical team.

      The investigators will assign extubation of preterm ventilated infants (50 preterm infant) in
      NICU of Military Hospital into HHFNC and extubation of preterm ventilated infants (50 preterm
      infant) in (NICU) of Gynecology and Obstetric department of Kasr El Aini hospital into NCPAP
      (50 preterm infant).
    

Intervention name(s): High flow nasal cannula vs. Nasal continuous positive airway pressure
Intervention type(s): Device
Intervention description(s): High flow nasal cannula
Observational model: Cohort
Time perspective: Prospective
Sampling method: Probability Sample
Study population: 
        The following study will be conducted in the neonatal intensive care unit (NICU) of
        Gynecology and Obstetric department of Kasr El Aini hospital and neonatal intensive care
        unit of Military Hospital throughout a time interval of at least 6 months for a minimum of
        100 preterm infants.

        Infants will be eligible for the study if they born at less than 34 weeks' gestation,
        required endotracheal intubation and positive pressure ventilation, and considered ready
        for extubation by the clinical team.
Effects of Fetal Positioning During Venipuncture
Condition: Preterm Neonates; Venipuncture
MeSH terms: Premature Birth
Study type: Interventional

Summary: 
      The study was aimed to examine the effects of fetal positioning during venipuncture on the
      neonates' pain score and physiological parameters (heart rate, blood-oxygen saturation, body
      temperature, crying duration) in neonatal intensive care unit (NICU).

      This randomized controlled clinical trial was conducted between 10.2021-07.2022 with 60
      preterm neonates, aged 26-32 week of gestation. Neonates were divided into intervention group
      (n=30) and control group (n=30) according to the randomization method. The neonates in the
      intervention group were put into fetal positioning at least 10 minutes before the procedure,
      and then venipuncture was performed. The fetal positioning was maintained throughout the
      procedure and the patient was kept in the fetal position for at least five more minutes after
      the procedure. Changes in the neonates' pain score and crying duration as well as heart rate,
      blood temperature, blood-oxygen saturation at three time points: before the procedure,
      immediately after needle insertion, five minutes after needle removal. Data was collected
      using the sociodemographic form, neonatal observation form and Neonatal Pain, Agitation and
      Sedation Scale (N-PASS). The collected data were analyzed using the SPSS 15 software.

      The main questions it aims to answer:

        1. Does fetal positioning have an effect on pain score of premature neonates?

        2. Does fetal positioning have an effect on heart rate of preterm neonates?

        3. Does fetal positioning have an effect on oxygen saturation of preterm neonates?

        4. Does fetal positioning have an effect on body temperature of the preterm neonates?

        5. Does fetal positioning have an effect on the crying duration of preterm neonates?
    

Detailed description: 
      Neonates who were hypotonic, lethargic, in shock or had seizures, stage 3-4 intracranial
      hemorrhage and a history of surgery were not included in the study. Additionally, neonates
      was taken any analgesic and/or sedative in the last 24 hours were excluded from the study.
    

Intervention name(s): Fetal Positioning
Intervention type(s): Behavioral
Intervention description(s): In the study, venipuncture was applied to the intervention and control groups. While the procedure was performed by an experienced neonatal nurse, the neonates' pain score, crying duration and physiological parameters were monitored by another researcher (observer).
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Supportive Care
Keywords: Preterm neonates; Venipuncture; Fetal positioning; Pain; Physiological parameters; Nursing
Comparison of Peak Airway Pressure and Gastric Insufflation in Manual Ventilation and Pressure-controlled Ventilation With Facemask During Anesthesia Induction in Children
Condition: Elective Urologic Surgeries
Study type: Interventional

Summary: 
      Comparison of peak airway pressure and gastric insufflation in manual ventilation and
      pressure-controlled ventilation with facemask during anesthesia induction in children.
    


Intervention name(s): manual ventilation; pressure-controlled ventilation
Intervention type(s): Other; Other
Intervention description(s): Anesthesia will be induced by propofol 1mg/kg via intravenous line. Once loss of eyelash reflex occurred, ultrasonography of antral area will be started by same physician. After administration of muscle relaxant (rocuronium 0.2-0.4mg/kg), manual ventilation will be performed with respiratory rate 20 breathes/min, I:E ratio of 1:1 and tidal volume with 9-10mL/kg. The pop-off valve will be set at 15cmH2O at fixed gas flow of 500mL/min of oxygen. Pressure-controlled ventilation will be performed with respiratory rate 20 breaths/min, I:E ratio of 1:1 and peak airway pressure will be set to get a tidal volume of 9-10mL/kg. The peak airway pressure during facemask ventilation will be checked. Another physician will auscultate the epigastric area to detect gastric insufflation during facemask ventilation. Ultrasonography of antral area will be checked once again after 3 minutes of facemask ventilation.; Anesthesia will be induced by propofol 1mg/kg via intravenous line. Once loss of eyelash reflex occurred, ultrasonography of antral area will be started by same physician. After administration of muscle relaxant (rocuronium 0.2-0.4mg/kg), manual ventilation will be performed with respiratory rate 20 breathes/min, I:E ratio of 1:1 and tidal volume with 9-10mL/kg. The pop-off valve will be set at 15cmH2O at fixed gas flow of 500mL/min of oxygen. Pressure-controlled ventilation will be performed with respiratory rate 20 breaths/min, I:E ratio of 1:1 and peak airway pressure will be set to get a tidal volume of 9-10mL/kg. The peak airway pressure during facemask ventilation will be checked. Another physician will auscultate the epigastric area to detect gastric insufflation during facemask ventilation. Ultrasonography of antral area will be checked once again after 3 minutes of facemask ventilation.
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Primary purpose: Other
Keywords: manual ventilation; pressure-controlled ventilation; peak airway pressure; antral area
Skeletal Health of Klinefelter Patients
Condition: Osteoporosis
MeSH terms: Osteoporosis; Klinefelter Syndrome
Study type: Interventional

Summary: 
      This study compared the bone health of KS patients who were actively monitored in our clinic
      by dual-energy X-ray absorptiometry (DXA) with that of a control group of healthy volunteers.
    

Detailed description: 
      Klinefelter syndrome (KS) is the most common chromosome number abnormality of men, occurring
      in 1/500 to 1/1000 live births . It was first described in 1942 as an endocrine disorder
      characterised by small, hard testicles androgen deficiency, gynaecomastia and increased
      follicle stimulating hormone (FSH). Osteoporosis is a progressive bone remodelling disorder
      in which bone loss exceeds bone formation. The resulting micro-architectural defects and bone
      fragility are associated with increased fracture risk and mortality. In KS, testosterone
      deficiency is associated with decreased bone mass and low bone mineral density (BMD) , and a
      positive correlation of total serum testosterone and BMD has been reported . There are some
      exceptions ; however, most studies have reported that KS increases the risk of osteopenia and
      osteoporosis compared with age-matched control groups.
    

Intervention name(s): dual-energy X-ray absorptiometry
Intervention type(s): Diagnostic Test
Intervention description(s): dual-energy X-ray absorptiometry
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Intervention model description: To compare bone mineral density of klinefelter patients and normal population
Masking: None (Open Label)
Primary purpose: Screening
Keywords: Klinefelter; Osteoporosis; dual-energy X-ray absorptiometry