bioihbjkbjnl/mcl2 huggingface dataset:
The Relationship Between Physical Activity Level and Fear of Birth (Tokophobia) in Pregnant Women
Condition: Fear of Childbirth
Study type: Observational

Summary: 
      The aim of this study is to determine the effects of physical activity on fear of childbirth
      (tokophobia) in pregnant women.
    

Detailed description: 
      Fear of childbirth is defined as the fear felt and experienced before, during and after
      birth. Fear of childbirth is an acceptable level of fear and motivates the woman to prepare
      for the birth. However, if the fear developed before pregnancy and/or the severity of the
      fear increased during pregnancy, this situation is called "Tokophobia".

      Physical activity is defined as body movements that are performed by using the body's muscles
      and joints, require energy expenditure above the basal level, can be performed at different
      intensities, increase heart rate and respiration, and occur with the contraction of large
      muscle groups.

      It has been shown in the literature that physical activity in pregnant women contributes to
      the health of both the mother and the infant.

      Several studies have reported the benefits of physical activity and exercise in preventing
      many risks of pregnancy, including lowering the risks of excess weight gain, preeclampsia,
      gestational diabetes, gestational hypertension, prenatal depression and macrosomia, and
      improving psychological well-being.

      Despite the reported benefits of regular physical activity in the literature, it has been
      reported that the level of physical activity during pregnancy is lower compared to the
      pre-pregnancy period.
    

Observational model: Case-Crossover
Time perspective: Prospective
Sampling method: Non-Probability Sample
Study population: 
        Healthy pregnant women
      
Keywords: pregnancy; fear of childbirth; tokophobia; physical activity
Efficacy of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild to Moderate Acne Vulgaris
Condition: Acne Vulgaris
MeSH terms: Acne Vulgaris
Study type: Interventional

Summary: 
      To compare the efficacy of 25% trichloroacetic acid peel versus 30% salicylic acid peel in
      mild to moderate acne vulgaris.

      Study Design: Randomized Control Trial. Place And Duration of Study: Department of
      Dermatology, CMH Abbottabad from 01 Jun 2022 to 30th Nov, 2022.

      Methodology: A total of 60 patients presented with mild or moderate acne vulgaris were
      randomized into two groups comprising 30 patients in each group and treated with either the
      TCA peel or the SA peel at 2-week intervals for 12 weeks. Patients in Group A were treated
      with 25% TCA peel whereas patients in Group B were treated with 30% SA peel. At the end of
      therapy after 12 weeks, evaluation of active acne was done by individual lesion counts
      (comedones, papules and pustules) and calculation of the Michaelsson acne score (MAS).
    


Intervention name(s): 25% TRICHLOROACETIC ACID; 30% salicylic acid
Intervention type(s): Drug; Drug
Intervention description(s): Patients of group A were treated with 25% TCA peel and patients at 2-week intervals for a total of 12 weeks. Clinical evaluation was done at the end of therapy after 12-weeks of treatment.; Patients of group B were treated with 30 % salicylic acid peel and patients at 2 weeks interval for a total of 12 weeks.clinical evaluation was done at the end of therapy after 12 weeks of treatment
Other intervention name(s): Peeling agent; Peeling agent
Intervention MeSH terms: Salicylic Acid; Salicylates
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Satiety Effects of the Combination of Egg and Whole Grains
Condition: Food Selection
Study type: Interventional

Summary: 
      The satiety effects of the combination of protein and fiber within egg and whole grain
      breakfast meals. High protein with low and high-fiber is hypothesized to be more satiating
      than low protein, low fiber.
    

Detailed description: 
      Subjects will consume 3 different breakfast meals. Satiety will be measured by visual
      analogue scales; food intake will be recorded at subsequent meal as well as 24 hour food log;
      blood glucose response will be assessed following test meals. Subjects will consume an ad
      libitum lunch meal 3.5 hours after breakfast meal and food intake will be measured.
    

Intervention name(s): Egg refined grain; Egg Whole Grain; Cereal Refined grain
Intervention type(s): Other; Other; Other
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Single (Participant)
Pilot Study of the Impact of Exercise on Hippocampal Function
Condition: Anxiety
Study type: Interventional

Summary: 
      The goal of this pilot study is to test the procedural aspects of the behavioral tests and
      the exercise components of the study. This includes establishing typical scores for anxiety
      patients in these behavioral tests, and administering and coaching anxiety patients in an
      at-home exercise regimen. This pilot study will produce the information necessary to design a
      larger future study including both patients and healthy control participants.
    

Detailed description: 
      This is a pilot study to explore whether High Intensity Interval Training (HIIT) aerobic
      exercise can improve performance on hippocampal dependent behaviors or anxiety measures .
      HIIT is a form of interval training that alternates short periods of high effort exercise
      with less intense recovery periods. Participants in this study will undertake a 6-week
      protocol of HIIT exercise, performed at home on a portable stepper device. Outcome measures
      for this study will be performance on two hippocampus-dependent behaviors and responses to
      mood and anxiety questionnaires.

      The hippocampus is a brain structure that is involved in learning and memory, and is one of
      the two sites of adult neurogenesis, the process of generating of new neurons from stem cells
      in the adult mammalian brain. Adult neurogenesis may represent a new target for the treatment
      of anxiety disorders. The tests in this study consist of a picture-based memory task and a
      location memory task. Eligible participants will complete both game tasks. In each test,
      participants will sit in front of a computer and play these games using the computer keyboard
      or a handheld video game controller.
    

Intervention name(s): High Intensity Interval Exercise
Intervention type(s): Behavioral
Intervention description(s): 6 week at-home aerobic exercise protocol
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Keywords: Neurogenesis; Memory; Spatial Processing; Hippocampus; Cognition; Aerobic Exercise
A Study of Mirikizumab (LY3074828) in Participants With Moderate to Severe Ulcerative Colitis
Condition: Ulcerative Colitis
MeSH terms: Colitis; Colitis, Ulcerative; Ulcer
Study type: Interventional
Phase: Phase 2

Summary: 
      The main purpose of this study is to test the hypothesis that treatment with mirikizumab is
      superior to placebo in providing clinical benefit to participants with moderate to severe
      ulcerative colitis (UC). This study will also investigate how the body processes the drug.
    


Intervention name(s): Mirikizumab; Placebo
Intervention type(s): Drug; Drug
Other intervention name(s): LY3074828
Intervention MeSH terms: Mirikizumab
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: IL-23 antibody
Reverse Medical Barrel™ Device for Adjunctive Treatment for Wide-Neck, Intracranial, Bifurcating/Branching Aneurysms
Condition: Intracranial Bifurcating Aneurysms
MeSH terms: Aneurysm
Study type: Interventional

Summary: 
      Single arm study to evaluate the outcomes of treatment with the Barrel VRD device as an
      adjunctive treatment to coiling for wide neck, intracranial, bifurcating/branching aneurysms
      in the middle cerebral and basilar arteries.
    


Intervention name(s): BARREL VRD
Intervention type(s): Device
Intervention description(s): The Barrel VRD was implanted as adjunctive to embolic coils in subjects with wide necked bifurcating aneurysms within the Middle Cerebral and Basilar Arteries.
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Post-exercise Appetite Responses in Type 1 Diabetes
Condition: Type 1 Diabetes Mellitus
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 1
Study type: Interventional

Summary: 
      The investigators hypothesise that manipulating the glycaemic index of the meal after
      exercise will influence the acute appetite responses of Type 1 diabetes individuals
    


Intervention name(s): Meal composition - Low versus high GI.
Intervention type(s): Dietary Supplement
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Basic Science
Keywords: Type 1 Diabetes Mellitus; Exercise; Appetite
Soy and Brain Vascular Function
Condition: Brain Vascular Function; Cerebral Blood Flow; Glucose Metabolism; Cognitive Performance
Study type: Interventional

Summary: 
      Cognitive performance is negatively related to an impaired glucose metabolism, possibly due
      to impairments in brain vascular function. Supported by the statement from the American Heart
      and American Stroke Association that healthy plant-based diets, which consist of soy foods,
      protect against cognitive decline, we now hypothesize that soy-induced changes in glucose
      metabolism cause beneficial effects on brain vascular function thereby improving cognitive
      performance. The primary objective of this intervention study is thus to evaluate in elderly
      men and women the effect of a 16-week soy intervention on cerebral blood flow, as quantified
      by the non-invasive gold standard magnetic resonance imaging (MRI) perfusion method Arterial
      Spin Labeling (ASL). Cerebral blood flow is a robust and sensitive physiological marker of
      brain vascular function. Secondary objectives are to examine effects on glucose metabolism
      using the oral glucose tolerance test and cognitive performance as assessed with a
      neurophysiological test battery.
    


Intervention name(s): Soy nuts
Intervention type(s): Dietary Supplement
Intervention description(s): Study volunteers will receive daily 70 g of soy nuts (roasted soybeans containing approximately 100 mg isoflavones). The amount of soy protein provided by the nuts equals the FDA recommended daily intake of 25-30 g.
Allocation: Randomized
Intervention model: Crossover Assignment
Intervention model description: Participants will receive, in random order, daily 70 g of soy nuts (soy treatment) or no food products (control treatment) for sixteen weeks, separated by a wash-out period of at least 8 weeks.
Masking: Double (Investigator, Outcomes Assessor)
Primary purpose: Prevention
Bioequivalence Study of Olanzapine Tablets, 5 mg Under Fed Study
Condition: Fed
MeSH terms: Malnutrition
Study type: Interventional
Phase: Phase 1

Summary: 
      The purpose of this study is to compare the bioequivalence and characterize the profile of
      the olanzapine tablets, 5 mg with zyprexa tablets, 5 mg in healthy, adult, human subjects
      under fed conditions and to monitor the adverse events and ensure the safety of the subjects.
    

Detailed description: 
      An open label, balanced, randomized, two-treatment, two-period, two-sequence, single oral
      dose, crossover, bioequivalence study of Olanzapine Tablets 5 mg of Dr. Reddy's Laboratories
      Limited, India, comparing with that of Zyprexa® (Olanzapine) Tablets 5 mg of Eli Lilly and
      Company, USA, in healthy, adult, human subjects under fed conditions.
    

Intervention name(s): Olanzapine
Intervention type(s): Drug
Intervention description(s): Olanzapine Tablets, 5 mg
Other intervention name(s): Zyprexa
Intervention MeSH terms: Olanzapine
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Primary purpose: Treatment
Safety and Tolerability of RNS60 Given by IV to Healthy Subjects
Condition: Myocardial Infarct
MeSH terms: Myocardial Infarction
Study type: Interventional
Phase: Phase 1

Summary: 
      The objective of this study is to evaluate the safety and tolerability of RNS60 administered
      intravenously to healthy subjects. 12 subjects will receive RNS60 or placebo at three
      escalating rates for 48 hours for each rate.
    


Intervention name(s): RNS60; Placebo
Intervention type(s): Drug; Drug
Intervention description(s): RNS60 for intravenous administration; 0.9% normal saline for injection
Intervention MeSH terms: RNS60
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary purpose: Treatment
A Study of AZD4901 in Females With Polycystic Ovary Syndrome
Condition: Polycystic Ovary Syndrome (PCOS), Female Endocrine Disorder
MeSH terms: Polycystic Ovary Syndrome; Endocrine System Diseases; Syndrome
Study type: Interventional
Phase: Phase 2

Summary: 
      To assess the effects of AZD4901 when given in multiple doses to females with Polycystic
      Ovary Syndrome
    


Intervention name(s): AZD4901 (oral); Placebo to match AZD4901
Intervention type(s): Drug; Drug
Intervention description(s): Patients randomized to 1 of 4 treatment groups: AZD4901 20 mg once a day, AZD4901 20 mg twice a day, AZD4901 40 mg twice a day or placebo; Patients randomized to 1 of 4 treatment groups: AZD4901 20 mg once a day, AZD4901 20 mg twice a day, AZD4901 40 mg twice a day or placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Basic Science
Keywords: Pharmacokinetics, Pharmacodynamics, endocrinopathies, PCOS, female, hormone, LH
The Results of Oxford Unicompartmental Knee Arthroplasty in Patients With and Without Preoperative Genu Recurvatum
Condition: Primary Gonarthrosis; Genu Recurvatum
MeSH terms: Osteoarthritis, Knee
Study type: Interventional

Summary: 
      The purpose of this study is to explore the effects of the Oxford unicompartmental knee
      arthroplasty on two groups of patients, namely one with genu recurvatum before the procedure
      and one without. Specifically, this study compare the number of occurrences of postoperative
      genu recurvatum and the postoperative hyperextension angles among the patients. Additionally,
      the knee scores, the pain scores, and the functional scores for the two groups of patients
      are compared.

      Materials and methods: This study prospectively followed 104 patients (114 knees) who had
      been treated with cemented minimally invasive surgery unicompartmental knee arthroplasty and
      had had a minimum of 24 months of follow-up. The patients were divided into two groups: those
      without preoperative genu recurvatum (85 patients; 94 knees) and those with preoperative genu
      recurvatum (19 patients; 20 knees). The incidence of the postoperative genu recurvatum, the
      postoperative hyperextension angles, the knee scores, the pain scores, and the functional
      scores were recorded and compared between two groups..
    

Detailed description: 
      The patients in both groups were applied with cemented Oxford unicompartmental knee
      arthroplasty with the same surgeon. The all patients were performed surgery with minimally
      invasive surgery technique. The gender, site, range of motion, alignment of prosthesis,
      operative time, blood loss, and posterior slope of tibial component also were recorded and
      compared between two groups. The incidence of postoperative genu recurvatum, gender, and site
      were computed using Fisher's exact test. The hyperextension angle, knee score, pain score,
      functional score,range of motion, alignment of prosthesis, posterior slope of tibial
      component, operative time, and blood loss were compared with student t-test.
    

Intervention name(s): Oxford unicompartmental knee arthroplasty
Intervention type(s): Device
Intervention description(s): The Oxford unicompartmental knee arthroplasty was applied in all patients with medial osteoarthritis knee.The Oxford unicompartmental knee arthroplasty is mobile bearing unicompartmental knee arthroplasty.
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary purpose: Treatment
Efficacy and Safety of Olanzapine in the Extended Treatment for Manic or Mixed Episode of Bipolar I Disorder
Condition: Manic or Mixed Episode Associated With Bipolar I Disorder
MeSH terms: Mania
Study type: Interventional
Phase: Phase 3

Summary: 
      The efficacy and safety of the extended treatment to patients with most recent episode manic
      or mixed who completed previous double blind study (F1D-JE-BMAC [Study BMAC]) will be
      examined.
    


Intervention name(s): olanzapine; lithium; valproate; carbamazepine
Intervention type(s): Drug; Drug; Drug; Drug
Intervention description(s): oral, daily; Dose adjusted according to local package insert; Dose adjusted according to local package insert; Dose adjusted according to local package insert
Other intervention name(s): LY170053; Zyprexa
Intervention MeSH terms: Carbamazepine; Valproic Acid; Olanzapine
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Treatment
B-slim, a Multi-source Digital Super Coach for Sustainable Weight Loss
Condition: Obesity
MeSH terms: Weight Loss
Study type: Interventional

Summary: 
      The purpose of this study is to carry out a field trial to evaluate the effectiveness and
      added value of the b-SLIM digital Super Coach in a convenient sample of overweight and obese
      adults.
    

Detailed description: 
      The purpose of this study is to carry out a field trial to evaluate the effectiveness of the
      b-SLIM digital Super Coach in a convenient sample of overweight and obese adults. The
      effectiveness will be evaluated at the individual level by means of a randomized trial. By
      combining or not combining the use of the b-SLIM digital Super Coach with a conventional
      physical activity and nutrition coaching, the effectiveness of the Super Coach of the
      (user-driven) 'Super Coach' compared to a conventional face to face weight loss program can
      be determined. Outcomes will be measured at the level of health behavior (i.e., physical
      activity and nutrition), body composition, physical fitness, psychosocial factors (e.g.,
      motivation) and program adherence. The field trial will take place in Leuven (Belgium).

      This study can be seen as a pilot trial. The central hypothesis of this field trial is that
      using the multi-source b-SLIM digital Super Coach will support and assist overweight and
      obese adults to change their health behavior (i.e., physical activity and nutrition) and to
      lose body weight by improving their self-control, self-determined motivation and attitude
      towards regular physical activity and healthy diet. The investigators will check if the Super
      Coach can be a valuable alternative for a conventional physical activity and nutrition
      coaching.
    

Intervention name(s): Digital Super Coach; Conventional face to face PA & dietitian; Digital Super Coach + minimal coaching; Waiting Group
Intervention type(s): Other; Other; Other; Other
Intervention description(s): Receive Digital Super Coach during 12 weeks; Receive 7 face-to-face contacts (dietary and physical activity advice); Receive 3 face-to-face contacts (dietary and physical activity advice); Receive Digital Super Coach during 12 weeks, after 12 weeks of no treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Primary purpose: Supportive Care
Keywords: Digital coaching; Sustainable weight loss; Self-determination theory; Obesity; Overweight; Diet; Physical activity
An Invivo Study to Compare the Stability of Dental Implants With or Without Platelet Rich Fibrin Application
Condition: Dental Implant
Study type: Interventional

Summary: 
      The purpose of this study was to evaluate the effects of (Platelet Rich Fibrin) PRF
      application on implant osseointegration in the early phase of healing.
    

Detailed description: 
      Objectives:Achieving accelerated implant osseointegration could provide immediate or early
      loading of implants. Platelet-rich fibrin (PRF) is widely used to accelerate soft and hard
      tissue healing. Activated platelets in PRF release growth factors resulting in cellular
      proliferation, collagen synthesis and osteoid production. The aim of this study was to
      compare the stability of dental implants inserted with one-stage surgical protocol with or
      without PRF application.

      Design: Non-randomized, Active Controlled Trial. Material and Methods: Twenty healthy
      patients (n=10 test group, n= control group) with adequate alveolar bone, having 2 or more
      adjacent missing teeth, extracted at least 6 months ago were included in this study. Minimum
      two tapered implants (Ankylosis, DentsplyFriadent) were placed to each patient. After
      surgical preparation of implant sockets, PRF that was prepared preoperatively was placed
      randomly to one of the sockets (PRF+). Acellular plasma portion of PRF was used to wet the
      implant placed into the PRF-coated socket. Resonance frequency measurements were made by
      Osstell ISQ after placement of implants, at 1 week and one month postoperatively.

      Key Words: Dental implant stability, Platelet Rich Fibrin, Resonance frequency analysis
    

Intervention name(s): Dental implant
Intervention type(s): Device
Intervention description(s): This longitudinal human clinical trial is designed to measure implant stability with the resonance frequency analyzer (Osstell, Integration Diagnostics AB, Sweden) at time of implant placement and up to 4 weeks post placement. delivered. No further follow-up will be done with the resonance frequency approach
Other intervention name(s): The implant in this protocol; 3.5 mm width and 11 mm length) ANKYLOS C/X dental implants were used (Dentsply, Hanau, Germany
Intervention model: Single Group Assignment
Masking: None (Open Label)
Primary purpose: Health Services Research
Keywords: Dental Implant,
Study to Investigate the Efficacy of a Non-hormonal Drug Against Endometriosis Associated Pelvic Pain
Condition: Endometriosis
MeSH terms: Endometriosis
Study type: Interventional
Phase: Phase 2

Summary: 
      This study was designed as a proof-of-concept trial to evaluate safety, tolerability, and the
      efficacy of 1800 mg (ZK 811752 600 mg given orally three times daily) over 12 weeks for the
      treatment of endometriosis associated pelvic pain (EAPP) in comparison to placebo.
    

Detailed description: 
      The study has previously been posted by Schering AG, Germany. Schering AG, Germany has been
      renamed to Bayer Schering Pharma AG, Germany.

      Bayer Schering Pharma AG, Germany is the sponsor of the trial.
    

Intervention name(s): CCR1-Antagonist (BAY86-5047, ZK811752); Placebo
Intervention type(s): Drug; Drug
Intervention description(s): Given orally in a dose of 600 mg three times daily over 12 weeks; Placebo
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary purpose: Treatment
Keywords: Endometriosis associated pelvic pain