Following a single intravenous dose of [14C]alendronate , approximately 50% of the radioactivity was excreted in the urine within 72 hours and little or no radioactivity was recovered in the faeces .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

After single dose intravenous administration of [14C] alendronate , approximately 50% of the radioactivity is excreted in the urine within 72 hours . Little or no radioactivity is found in the faeces .


Following treatment , ticks will detach from the host within 24 to 48 hours after infestation; however , single ticks might remain on the animal .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

After treatment , ticks will detach from the host within 24 to 48 hours after infestation . However , some ticks can remain attached to the animal .


For EE , slight increases were observed due to treadmill and other aerobic exercise; however , the Css values following these treatments were within the reference range .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

For EE , a slight increase was seen with the treadmill and other aerobic exercise . However , the Css values following these treatments were within the reference limits .


For cereals and products of plant origin including fruit and vegetables , residue levels reflect the use of minimum quantities of pesticides necessary to achieve effective protection of plants , applied in such a manner that the amount of residue is both as low as practicable and toxicologically acceptable , having regard in particular to the protection of the environment and to the protection of the consumers notably in terms of the estimated dietary intake by consumers .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In the case of cereals and products of plant origin , including fruit and vegetables , the residue levels reflect the use of the minimum amount of pesticides required to achieve effective plant protection . These are to be used in such a way that the amount of residue is as low as possible and toxicologically justifiable , particularly with regard to environmental protection and the estimated consumption by consumers with food .


For practical reasons , a rate that approximates the actual rate at the date of the transaction is often used , for example , an average rate for a week or a month might be used for all transactions in each foreign currency occurring during that period .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

For practical reasons , an approximate value is often used that comes close to the actual rate at the time of the business transaction . For example , the average exchange rate for a week or a month can be used for all business transactions in this period in the relevant foreign currency .


For raw cereals other than maize , no data have been submitted and therefore the maximum levels established for cereals intended for direct human consumption should apply as from 1 July 2001 also to cereals to be subjected to sorting or other physical treatment before human consumption or use as an ingredient in foodstuffs .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

No data was submitted for unprocessed cereals other than maize . Consequently , the maximum levels established for cereals intended for direct human consumption should also apply from 1 July 2001 to cereals intended to be subjected to sorting or other physical treatment before human consumption or use as an ingredient of foodstuffs .


For section 4 . 4 , the CHMP implemented a revised wording for the hyperprolactinaemia section , excluding specific mention of prolactinoma and breast cancer , as although data supporting a possible relationship between hyperprolactinaemia and risk of some prolactin-dependent tumours exists , the data is still largely inconclusive from a clinical perspective .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In Section 4 . 4 , the CHMP introduced revised wording for the section on hyperprolactinemia , excluding specific statements on prolactinoma and breast cancer . Indeed , although there is some evidence to support a possible relationship between hyperprolactinemia and the risk of developing certain prolactin-dependent tumors , most of it is still clinically inconclusive .


For some of the anorectic agents , some Marketing Authorisation Holders ( Annex IV ) appealed against the opinion and the grounds for appeal were received on 15 and 30 April 1996 .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

For some anorectic agents , some marketing authorization holders ( Annex IV ) have appealed against this opinion . The grounds for their appeal were received on April 15 and 30 , 1996 .


For some of the anorectic agents , some Marketing Authorisation Holders ( Annex IV ) appealed against the opinion and the grounds for appeal were received on 30 April 1996 .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

For some anorectic agents , some marketing authorization holders ( Annex IV ) have appealed against this opinion . The reasons for their appeal were received on April 30 , 1996 .


For some people stopping smoking , with or without treatment , has been associated with an increased risk of experiencing feelings such as depression and anxiety and can be associated with a worsening of psychiatric illness .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In some people , stopping smoking with or without treatment has been associated with an increased risk of developing depression or anxiety . Additionally , quitting smoking may be associated with worsening psychiatric illnesses .


For the indication in Manic episodes associated with Bipolar Disorders , the CHMP assessed the safety and efficacy of the proposed 2 mg and 3 mg starting doses and noted that no comparisons on the change in efficacy measurements in the first days of treatment were made .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In the indication of manic episodes associated with bipolar disorder , the CHMP assessed the safety and efficacy of the proposed starting doses of 2 mg and 3 mg . He noticed that no comparison of the variation in measures of the drug's effectiveness in the first few days of treatment had been made .


For these reasons , it is considered that there is a correlation between the increase in imports at low prices and the serious injury suffered by the Community producers , and that the increase in imports has had injurious effects in particular in terms of pressure on prices and a reduction in the volume sold by the Community producers on the Community market .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

For these reasons , it is considered that there is a link between the increased imports of cheap products and the serious injury suffered by the Community industry . The increased imports had an injurious effect as it put pressure on prices and decreased the sales volume of the Community producers in the Community .


Formal male fertility studies have not been conducted; however , microscopic evaluation of male reproductive organs from repeat-dose toxicity studies in cynomolgus monkeys at doses up to approximately 5-fold the human dose on a mg/ kg basis , revealed no differences compared to control male monkeys .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

No fundamental studies on male fertility have been conducted . However , microscopic observation of male reproductive organs in repeated dose toxicity studies in the Cynomolgus monkey , at doses approximately 5 times the human dose expressed in mg / kg , showed no difference from male monkeys controls .


Furthermore since metabolism of varenicline represents less than 10% of its clearance , active substances known to affect the cytochrome P450 system are unlikely to alter the pharmacokinetics of varenicline ( see section 5 . 2 ) and therefore a dose adjustment of CHAMPIX would not be required .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In addition , since metabolism contributes less than 10% of the clearance of varenicline , the active substances known to have an effect on cytochrome P450 are unlikely to alter the pharmacokinetics of varenicline ( see section 5 . 2 ) . Therefore , dosage adjustment of CHAMPIX is not normally required .


Given the lack of cooperation from Indonesian exporters , the price comparison was made on the basis of Eurostat data duly adjusted for customs duties and post importation costs and compared , at the same level of trade , to Community producers' ex-works prices .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Due to the lack of cooperation from the Indonesian exporters , the comparison was made on the basis of Eurostat data , adjusted for customs duties and post-importation costs . These prices were compared at the same level of trade with the prices of the Community producers ex works .


Given the seriousness of the adverse reaction and the implications on public health it was agreed on May 17 , 1995 by the CPMP that the issue was of community interest and anorectic agents concerned were identified on June 8 , 1995 .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Given the seriousness of the side effect and the consequences for public health , the CSP recognized on May 17 , 1995 that the problem was of Community interest . The appetite suppressants concerned were identified on June 8 , 1995 .


Half of the patients in each group were already being treated with intravenous epoprostenol and the dose of epoprostenol remained constant for the duration of the trial .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

At inclusion in the trial , half of the patients in each group were treated with intravenous epoprostenol . The dose of epoprostenol was not changed throughout the trial .


Having determined , after consulting the Advisory Committee , that sufficient evidence existed for the initiation of a partial interim review , the Commission published a notice in the Official Journal of the European Communities ( 3 ) and commenced an investigation .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The Commission , after consultation in the Advisory Committee , determined that there was sufficient evidence to initiate a mid-term review . It published this in the Official Journal of the European Communities ( 3 ) and started an investigation .


He moved to the German Federal Ministry for Health in 1975 where he has served in various posts , including in the division responsible for veterinary pharmaceutical sector , and in 1990 he collaborated in the reconstruction of the veterinary services in the new federal Lander .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

He joined the German Federal Ministry of Health in 1975 where he held various positions , notably in the department responsible for the veterinary pharmaceuticals sector . In 1990 he took part in the reconstruction of the veterinary services in the new Lander .


Hold pipette in upright position , twist and pull off cap and use the opposite end of the cap to break the seal .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Hold the pipette in an upright position , twist and pull the cap . Use the cap upside down to screw on and puncture the pipette opening .


Homocystinuria is a disease caused by the accumulation of homocysteine which is not converted to cysteine and is characterized by formation of clots in the veins , bone weakness , and skeletal and crystalline lens abnormalities .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Homocystinuria is a disease caused by the build-up of homocysteine that is not converted to cysteine . It is characterized by the formation of clots in the veins , brittle bones and abnormalities of the skeleton and lens .


However , as the liver and kidney are frequently removed from carcasses moving in international trade , maximum residue limits should consequently be established always for muscle or fat tissues .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

However , liver and kidneys are often removed from carcasses in international trade . For this reason , maximum levels should always be set for residues in muscle or fat tissue .


However , because maternal IgG is excreted in human milk , and rituximab was detectable in milk from lactating monkeys , women should not breastfeed while treated with MabThera and for 12 months following MabThera treatment .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

However , maternal IgG passes into milk , and rituximab has been detected in breast milk in monkeys . Therefore , women should not breast-feed while taking MabThera and for 12 months after stopping it .


However , dizziness has been reported in some patients during treatment with regimens containing PREZISTA co-administered with 100 mg ritonavir and should be borne in mind when considering a patients ability to drive or operate machinery ( see section 4 . 8 ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

However , cases of dizziness have been reported in some patients receiving treatment with PREZISTA co-administered with 100 mg ritonavir . This should be taken into account when assessing a patient's ability to drive or use machines ( see section 4 . 8 ) .


However , if intercourse has already occurred , pregnancy should be excluded before the actual start of EVRA or the woman has to wait for her first menstrual period .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

However , if intercourse has already occurred , you will need to rule out pregnancy before you can start EVRA . Otherwise the woman will have to wait for her first menstrual cycle .


However , in combining with platinum agents , there is a distinct sequence-dependent interaction depending on whether the platinum agent is given on day 1 or 5 of the topotecan dosing .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

However , there is a distinct and sequence-dependent interaction when combined with platinum derivatives . This interaction depends on the day of administration of the platinum derivative: day 1 or day 5 of administration of topotecan .


However , maropitant can produce acute eye irritation and in the case of accidental eye exposure , flush the eyes with plenty of water and seek medical attention .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

However , maropitant may cause severe eye irritation . In case of accidental eye exposure , rinse thoroughly with water and consult a doctor .


However , patients should be advised that they may experience undesirable effects such as dizziness , light-headedness or fainting spells during treatment and told not to drive or operate machines in such circumstances .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

However , patients should be informed of the potential side effects of the treatment , such as dizziness , lightheadedness or fainting . They will then be advised not to drive or use machines in such circumstances .


However , the Commission has already indicated that compensation is not necessary for the period from January 1992 to July 1994 , during which Adriatica took part in a prohibited pact .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

However , the Commission has already pointed out that the compensation was not necessary between January 1992 and July 1994 . During this period Adriatica participated in an illegal price agreement .


IONSYS is not recommended for use in patients who have received monoamine oxidase ( MAO ) inhibitors within 14 days because severe and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The use of IONSYS is not recommended in patients who have received monoamine oxidase inhibitors ( MAOIs ) within the previous 14 days . Serious and unpredictable potentiation of the effects of opioid analgesics by MAOIs has been observed .


Ibuprofen competes with bilirubin for albumin binding in newborn infant serum and , as a consequence , the free fraction of bilirubin may be increased at high ibuprofen concentrations .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Ibuprofen competes with bilirubin for binding to albumin in newborn serum . The free fraction of bilirubin could therefore be increased at high concentrations of ibuprofen .


Idursulfase is a purified form of the lysosomal enzyme iduronate-2-sulfatase , produced in a human cell line providing a human glycosylation profile , which is analogous to the naturally occurring enzyme .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Idursulfase is a purified form of the lysosomal enzyme iduronate-2-sulfatase . It is produced from a human cell line giving it a human glycosylation profile similar to that of the naturally produced enzyme .


If , however , no such agreement is reached on sharing the information , the Commission may decide to disclose information necessary to avoid repeating toxicological tests on vertebrates , while ensuring a reasonable balance between the interests of the parties concerned .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

If no such agreement on data sharing is reached , the Commission may decide to make public the information necessary to prevent a repetition of toxicological tests on vertebrates . It ensures that the interests of the parties involved remain reasonably balanced .


If at least 20 % of the cartons of a particular cut are found to be in breach , the whole day's production of that particular cut shall be rejected by the intervention agency and no payment shall be due; the boning plant shall pay the intervention agency an amount equal to the price shown in Annex VIII for the cuts that have been rejected .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

If at least 20% of the cardboard boxes filled with the section in question have demonstrably not complied with , the entire daily production for this section will be rejected by the intervention agency and payment will not be owed . In this case the cutting plant shall pay the intervention agency an amount equal to the price set out in Annex VIII for the cuts that have been rejected .


If legal aid is granted , it must cover the entire proceeding , including expenses incurred in having a judgment enforced; the recipient should continue receiving this aid if an appeal is brought either against or by the recipient in so far as the conditions relating to the financial resources and the substance of the dispute remain fulfilled .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

If legal aid is granted , it must cover the entire procedure , including the costs incurred for a judgment to be declared enforceable or enforced . The beneficiary should continue to receive this aid if an appeal is brought either against him or by him , as long as the conditions relating to financial resources and the substance of the dispute continue to be met .


If more than 12 hours has elapsed since missing a dose at the normal time , the patient should not take the dose , but take the next dose at the normal time on the following day .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Beyond 12 hours after forgetting , the missed dose should not be caught up . The next dose will be taken at the normal time the next day .


If not used immediately , in-use storage times and conditions prior to use are the responsibility of the user and should not be longer than 24 hours at 2 to 8C .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

If it is not used immediately , the user becomes responsible for estimating the shelf life and conditions of the product . However , it should not be stored for more than 24 hours at 2 to 8 C .


If not used immediately , in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than the above mentioned conditions when dilution has taken place in controlled and validated aseptic conditions .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

If the diluted product is not used immediately , storage times and conditions after dilution and before use are the responsibility of the user . They should normally not exceed the times mentioned above when dilution has taken place under controlled and validated aseptic conditions .


If treatment with Replagal makes your body produce antibodies this will not stop Replagal working and the antibodies may disappear with time .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Treatment with Replagal may cause your body to make antibodies . This will not affect how Replagal works , and the antibodies may go away over time .


If you become pregnant while taking Clopidogrel Winthrop , consult your doctor immediately as it is recommended not to take clopidogrel while you are pregnant .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

If you become pregnant while taking Clopidogrel Winthrop , consult your doctor immediately . It is recommended that you do not take clopidogrel when you are pregnant .


If you become pregnant while taking Iscover , consult your doctor immediately as it is recommended not to take clopidogrel while you are pregnant .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

If you become pregnant while taking Iscover , consult your doctor immediately . It is recommended that you do not take clopidogrel when you are pregnant .


If you become pregnant while taking Plavix , consult your doctor immediately as it is recommended not to take clopidogrel while you are pregnant .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

If you become pregnant while taking Plavix , consult your doctor immediately . It is recommended that you do not take clopidogrel when you are pregnant .


If you have depression , your doctor may still prescribe Avonex for you , but it's important to let your doctor know if you have had depression or any similar problems affecting your moods .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

If you have depression your doctor may still prescribe Avonex for you . However , it is important to let your doctor know that you have had depression or a similar problem affecting your mood .


If your doctor notices that you are suffering from , or are likely to suffer from , any of these severe side- effects described above , you will be immediately transferred to an intensive care unit ( ICU ) within the hospital , where your doctor can more closely monitor you and prescribe suitable treatment to deal with any dangerous side-effects which have developed .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

If your doctor notices that you are suffering from any of the above serious side effects or thinks you may have them , they will immediately transfer you to the intensive care unit of the hospital . Doctors will be able to monitor you more closely and prescribe you the right treatment to combat possible serious side effects .


Impairment of fertility Men being treated with cladribine are advised not to father a child up to 6 months after treatment and to seek advice of cryoconservation of sperm prior to treatment because of the possibility of infertility due to therapy with cladribine ( see Section 5 . 3 Preclinical safety data ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Impaired fertility Men taking cladribine are advised not to father a child for 6 months after stopping treatment . Possible cryopreservation of semen before treatment should be considered due to the risk of subfertility associated with treatment with cladribine ( see section 5 . 3 ) .


Important information about some of the ingredients of Zyrtec Zyrtec film-coated tablets contains lactose; if you have been told by your doctor that you have an intolerance to some sugars , please contact your doctor before taking this medicinal product .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Important information about some of the ingredients of Zyrtec Zyrtec , film-coated tablet contains lactose . If you have an intolerance to some sugars , ask your doctor for advice before taking this medicine .


Imports of meat from other Member States amount to approximately 16 % of all meat consumed in France and are mainly intended for home catering .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Meat imports from other Member States account for about 16% of the total meat consumption in France . This meat is mainly intended for home use .


In 2001 , production destined for sales declined by 7 % to 1 , 92m tonnes so that , relative to production sold on the free market , imports increased by over 32 % ( to 9 , 8 % of production sold on the free market ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In 2001 , production destined for sale decreased by 7% , to 1 . 92 million tons . Imports therefore increased by more than 32% relative to production sold on the free market ( to represent 9 . 8% of this production ) .


In a clinical study where a mock-up formulation of aluminium-adjuvanted whole virus vaccine ( AH9/ N2 ) containing 3 . 8 g HA was evaluated following a 0 , 10 day schedule , it has been shown that a faster onset of protection could be reached as compared to the recommended 0 , 21 day schedule .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In a clinical study , a prototype whole virion vaccine with aluminum ( adjuvant ) ( AH9 / N2 ) containing 3 . 8 g HA was evaluated according to the 0 , 10 days schedule . Faster protection was obtained compared to the 0 . 21 day regimen .


In a placebo-controlled , double-blind , study , 98 adults 60 years of age or older received a second dose of ZOSTAVAX 42 days following the initial dose; the vaccine was generally well tolerated .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In a double-blind , placebo-controlled study , 98 adults aged 60 years or older received a second dose of ZOSTAVAX 42 days after the initial dose . The vaccine was generally well tolerated .


In a second 12 month recurrence prevention study in manic episode patients who achieved remission with a combination of olanzapine and lithium and were then randomised to olanzapine or lithium alone , olanzapine was statistically non-inferior to lithium on the primary endpoint of bipolar recurrence ( olanzapine 30 . 0% , lithium 38 . 3%; p = 0 . 055 ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

A second randomized study evaluating the non-inferiority at 12 months of olanzapine versus lithium in the prevention of recurrence , in patients who have achieved remission of a manic episode , after treatment combining olanzapine with lithium , was conducted . Olanzapine was statistically non-inferior to lithium in relapse rate , the primary endpoint of the study ( olanzapine 30 . 0% , lithium 38 . 3%; p = 0 . 055 ) .


In a single-arm , open-label clinical study of treatment with romiplostim in patients with MDS , there were reported cases of progression to acute myeloid leukaemia ( AML ) , however this is an expected clinical outcome of MDS and the relationship to romiplostim treatment is unclear .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In a single-arm clinical study evaluating romiplostim in patients with MDS , cases of progression to acute myeloid leukemia ( AML ) were observed . However , this is an expected clinical course of MDS and the relationship to romiplostim is unclear .


In accordance with Article 11 ( 9 ) of the basic Regulation , the Commission used the same methodology as in the original investigation , so normal value was determined on the basis of information obtained in a market economy third country ( the analogue country ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In accordance with Article 11 ( 9 ) of the basic Regulation , the Commission applied the same methods used in the original investigation . Therefore , normal value was established on the basis of information obtained in a market economy third country ( hereinafter referred to as the "analogue country" ) .


In addition , Kinzalkomb should be used with caution in patients with impaired hepatic function or progressive liver disease , since minor alterations of fluid and electrolyte balance may precipitate hepatic coma .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Kinzalkomb should be used with caution in patients with impaired liver function or active liver injury . In such patients , even a minor change in fluid or electrolyte balance can trigger hepatic coma .


In addition , MicardisPlus should be used with caution in patients with impaired hepatic function or progressive liver disease , since minor alterations of fluid and electrolyte balance may precipitate hepatic coma .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

MicardisPlus should be used with caution in patients with impaired hepatic function or active hepatic impairment . In such patients , even a minor change in fluid or electrolyte balance can trigger hepatic coma .


In addition , rosiglitazone inhibited ovarian oestradiol and progesterone synthesis and lowered plasma levels of these hormones resulting in effects on oestrus/ menstrual cycles and fertility ( see section 4 . 4 ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In addition , rosiglitazone inhibits the ovarian synthesis of estradiol and progesterone thus lowering the plasma concentrations of these hormones . This causes effects on menstrual cycles and fertility ( see section 4 . 4 ) .


In addition to the drug related adverse reactions described above , adverse events ( reported regardless of causal relationship to medicinal product ) occurring in at least 5% and more commonly in patients treated with sitagliptin included upper respiratory tract infection and nasopharyngitis .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In addition to the drug-related adverse reactions described above , adverse reactions have been reported regardless of the causal relationship with the drug in at least 5% of patients , and more frequently in those treated with sitagliptin . They included upper respiratory tract infections and nasopharyngitis .


In addition to the drug-related adverse experiences described above , adverse experiences reported regardless of causal relationship to medication and occurring in at least 5% and more commonly in patients treated with TESAVEL included upper respiratory tract infection and nasopharyngitis .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In addition to the drug-related adverse reactions described above , adverse reactions have been reported regardless of the causal relationship with the drug in at least 5% of patients , and more frequently in those treated with TESAVEL . They included upper respiratory tract infections and nasopharyngitis .


In all of the studies , all of the patients also received ciclosporin and corticosteroids , and the main measure of effectiveness was the proportion of patients whose new organ had been rejected after six months .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In all studies , all patients also received ciclosporin and corticosteroids . The main measure of effectiveness was the proportion of patients whose new organ was rejected at six months .


In cattle , the volume administered per injection site should not exceed 7 ml; consecutive daily doses have to be administered at different injection sites .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In cattle , the volume administered should not exceed 7 ml per injection site . From one day to the next , the doses should be given to different injection sites .


In chronic hepatitis C , Pegasys has been studied on its own in three studies involving a total of 1 , 441 patients , and in combination with ribavirin in one study involving 1 , 149 patients .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

For chronic hepatitis C , Pegasys monotherapy has been studied in three studies involving a total of 1 , 441 patients . It has also been studied in combination with ribavirin in a study involving 1 , 149 patients .


In clinical studies approximately 5% of subjects receiving abacavir develop a hypersensitivity reaction; some of these cases were life-threatening and resulted in a fatal outcome despite taking precautions .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In clinical studies , hypersensitivity reactions have been observed in approximately 5% of patients treated with abacavir . In some cases , these hypersensitivity reactions have been life-threatening and sometimes have fatal outcome , despite precautions being taken .


In clinical trials with pioglitazone there was evidence of dose related weight gain , which may be due to fat accumulation and in some cases associated with fluid retention .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Clinical trials with pioglitazone have shown dose-dependent weight gain . This weight gain is linked to the accumulation of fat associated in some cases with fluid retention .


In conclusion , the Commission finds , firstly , that over the period 1988 to 1994 the public funds paid by the French authorities to France 2 and France 3 were lower than the cost of their public service activity and secondly that there is no conclusive evidence of anticompetitive behaviour by the public broadcasters on the market in the sale of advertising slots .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The Commission concludes that , firstly , the public funds granted to France 2 and France 3 in the period 1988-1994 are lower than the costs incurred by the broadcasters in connection with their public service activities . On the other hand , that there are no indications of anti-competitive behavior on the part of public television broadcasters when selling advertising time .


In dogs , these adverse reactions occur generally within the first treatment week and are in most cases transient and disappear following termination of the treatment but in very rare cases may be serious or fatal .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

These side effects usually appear during the first week of treatment . They are in most cases transient and go away after stopping treatment , but in very rare cases they can be severe or fatal .


In every Member State , two- or three-wheel motor vehicles must , as regards speedometers , display certain technical characteristics laid down as compulsory requirements that vary from Member State to Member State; such variation constitutes an obstacle to intra-Community trade .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Two-wheel and three-wheel motor vehicles in the individual Member States must have certain technical characteristics with regard to the speedometer which are laid down in binding requirements that differ from Member State to Member State . These differences hinder intra-Community trade .


In exceptional cases where the draft assessment report clearly does not fulfil those requirements the Commission shall agree with the EFSA and the rapporteur Member State on a period for resubmission of an amended report which shall not exceed three months .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In exceptional cases , where the draft assessment report clearly does not meet the formal requirements recommended by the Commission , the Commission shall agree with EFSA and the rapporteur Member State on a deadline for resubmitting an updated report . This period may not exceed three months .


In four patients , zidovudine-resistant isolates tested in vitro retained susceptibility to nevirapine and in six patients nevirapine-resistant isolates were susceptible to zidovudine and didanosine .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Strains from four patients exhibited resistance to zidovudine in vitro but remained susceptible to nevirapine . Strains isolated from six patients resistant to nevirapine remained susceptible to zidovudine and didanosine .


In its communication of 20 May 1999 entitled "the Status of OCTs associated with the EC and options for 'OCT 2000'" , the Commission examined the features and the development of the OCT-EC association since 1957 , noted the basic principles and the current situation of the association and sketched out alternative policies for it for the period beginning 1 March 2000 .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The Commission , in its Communication "Review of the status of the EC associated OCTs and guidelines for OCT 2000" of 20 May 1999 , analyzed the nature and evolution of the association of the OCTs with the Community since 1957 . In that text she referred to the basic principles and the current context of that association , and outlined the possibilities for developing it further in the course of the period starting on 1 March 2000 .


In multifocal patients , the risk for CDMS was independent from MRI findings at baseline , indicating a high risk for CDMS because of the dissemination of the disease based on clinical findings .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In patients with multifocal onset , the risk of clinically defined MS was independent of baseline MRI results . These patients were considered to be at high risk for clinically defined MS due to the spread of their disease as evidenced by clinical findings .


In no case has it been shown conclusively that reactions were actually caused by the vaccine; however , the data suggest the possibility that some of these cases may have been caused by measles vaccines .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In no case has it been conclusively shown that the side effects were actually induced by the vaccine . However , the data suggest that some of these cases could have been induced by measles vaccines .


In order for it to be authorised by the Commission , restructuring aid must fulfil a second condition , namely that measures must be taken to mitigate as far as possible any adverse effects of the aid on competitors .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

For restructuring aid to be approved by the Commission , it must meet a second condition . Indeed , measures must be taken to mitigate as far as possible any adverse effects of the aid on competitors .


In order to allow legitimate expectations to be fulfilled for existing stocks of pesticides to be used , the Commission non-inclusion Decisions allowed a phasing out period , and it is appropriate that MRLs premised on the notion that use of the substance concerned is not authorised in the Community , should not apply until the end of the phasing out period applying to that substance .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In order to meet legitimate expectations regarding the use of existing stocks of pesticides , a transitional period is foreseen in the Commission decisions on non-inclusion . It is recommended that MRLs based on the principle that the use of the substance in question is not authorized in the Community should apply only after the end of the transitional period set for that substance .


In order to authorise a plant protection product , Member States must apply the uniform principles provided for in Annex VI to Directive 91/414/EEC in evaluating , in particular , a dossier conforming to the requirements of Annex III to Directive 91/414/EEC , submitted by the applicant for authorisation .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

When authorizing a plant protection product , the Member States must apply the uniform principles set out in Annex VI to Directive 91/414 / EEC . This applies in particular to the evaluation of documents in accordance with the requirements of Annex III of Directive 91/414 / EEC , which are submitted by the applicant for approval .


In order to determine whether there was a likelihood of continuation of dumping , the Commission investigated the existence of current dumping on exports from the countries concerned to the Community on the grounds that if dumping was taking place , then it was reasonable , in the absence of any information to the contrary , to consider that it would be likely to continue in the future .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In order to determine whether there was a likelihood of continuation of dumping , the Commission investigated the current dumping practices affecting exports from the countries concerned to the Community . Indeed , if dumping takes place , it is reasonable to consider , in the absence of information to the contrary , that it is likely to continue in the future .


In particular , it considers that the conditions laid down in the programme act in respect of towage , in particular the criteria "at sea with a clearance certificate" , are insufficient to prevent unfair competition within the Community in the port towage sector , asking the Commission to extend the formal investigation procedure also to this aspect of the programme act .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In particular , it considers that the conditions laid down in the program law for towage , in particular the criteria "with certificate" and "at sea" , are not sufficient to prevent unfair competition in the harbor towage sector within the Community . It therefore asks the Commission to extend the formal investigation procedure also to this aspect of the program law .


In pigs it is injected into a muscle , and the dose is divided in pigs weighing over 80 kg so that no more than 2 ml are injected at one site .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In pigs , it is injected into a muscle . The dose is divided in pigs over 80 kg so that no more than 2 ml is injected at a single site .


In reproductive toxicity studies with fosamprenavir in rats , male fertility was not affected , but in females gravid uterine weights , numbers of ovarian corpora lutea and uterine implantation sites were reduced .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In reproductive toxicity studies with fosamprenavir in rats , male fertility was not affected . However , in pregnant females , a decrease in uterine weight , number of ovarian corpora lutea and uterine implantation sites was observed .


In schizophrenia , Zyprexa tablets have been studied in about 3 , 000 adults , in which their effectiveness was compared with that of placebo ( a dummy treatment ) or haloperidol ( another antipsychotic medicine ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Regarding schizophrenia , Zyprexa tablets have been studied in approximately 3000 adult patients . Their effectiveness has been compared with either placebo ( a dummy treatment ) or haloperidol ( another neuroleptic ) .


In serious , but rare cases , an ovarian hyperstimulation syndrome with clearly enlarged ovaries , can go hand in hand with possible accumulation of fluid in the abdomen or thorax as well as more serious thromboembolic complications .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

233 be practiced as soon as possible . In severe but rare cases , ovarian hyperstimulation syndrome with enlargement of the ovaries may be accompanied by a possible accumulation of fluid in the abdomen or thorax as well as more serious thrombosis complications .


In the case of concentrated butter with a minimum butterfat content of less than 99 , 8 % , the aforesaid quantities shall be reduced proportionally by 1 , 23 kg and 1 , 26 kg respectively per percent difference between the minimum butterfat content of the concentrated butter produced and the aforesaid figure of 99 , 8 % .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Concentrated butter contains at least 99 . 8% butterfat . When the concentrated butter contains less butterfat , the aforementioned quantities of butter are reduced proportionately by 1 . 23 kg and 1 . 26 kg respectively for each percent of butterfat that the concentrate contains less than 99 . 8% .


In the event of once daily dosing when the patient has a history of nocturnal symptoms the dose should be given at night and when the patient has a history of mainly day-time symptoms the dose should be given in the morning .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The time you take Seretide will depend on how often you have symptoms . If the predominance of symptoms is nocturnal , Seretide should be administered in the evening; if it is daytime , Seretide will be administered in the morning .


In the event of overdosage , patients should be monitored for signs and symptoms of hypocalcaemia , and treatment should be symptomatic and supportive .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In case of overdose , signs and symptoms of hypocalcaemia should be looked for . Treatment should be symptomatic and adjuvant .


In the first study , type A resistant patients ( A-non responders ) were randomised to receive placebo or 10 , 000 U of NeuroBloc and in the second , type A toxin responsive patients ( A-responders ) were randomised to receive placebo , 5000 U or 10 , 000 U of toxin .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In the first study , patients resistant to type A ( A-non-responders ) received , after randomization , either a placebo or 10 , 000 U of NeuroBloc . In the second , patients responding to type A toxin ( A-responders ) were randomized to receive either a placebo or 5 , 000 U or 10 , 000 U of toxin .


In the treatment of acute manic episodes in adults with bipolar disorder , Zyprexa tablets were compared with placebo , haloperidol or valproate ( another medicine used in manic episodes ) in five studies , including one where patients were also receiving other medicines .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

For the treatment of acute manic episodes , Zyprexa tablets have been studied in adult patients with bipolar disorder . Their efficacy has been compared with that of placebo , haloperidol , or valproate ( another medicine used during manic episodes ) in five studies , including one in patients who were also receiving other medicines .


In the treatment of generalised anxiety disorder , eight studies involved over 3 , 000 patients , the effectiveness of Lyrica was measured using an anxiety questionnaire ( Hamilton Anxiety Rating Scale ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Regarding the treatment of generalized anxiety disorder , eight studies have been carried out on more than 3 , 000 patients . Lyrica's effectiveness was measured using an Anxiety Rating Scale ( HARS ) questionnaire .


In the years after 2005 , the budgetary outcome could be worse than projected in the programme , although the general government deficit is likely to remain below 3 % of GDP .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In the years after 2005 , the budgetary result may turn out to be less favorable than expected in the program . The government deficit is likely to remain below 3% of GDP .


In their letter dated 16 September 2002 , the Greek authorities requested an extension of the deadline to respond to the comments of interested parties , and informed the Commission that the Greek Government contemplated the abolition of the contested State aid measures , by law .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

By letter dated 16 September 2002 , the Greek authorities requested an extension of the deadline for replying to third party comments . They also informed the Commission that the Greek government was envisaging by law abolishing the disputed aid measures .


In this respect , it should be noted that the conditions for initiation , and in particular the 25 % and 50 % thresholds of Article 10 ( 8 ) , were met and , therefore , the initiation of the investigation was warranted .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

However , the conditions for initiating a procedure were met , and in particular the 25% and 50% thresholds referred to in Article 10 ( 8 ) . The initiation of the investigation was therefore justified .


Investment banking would in future no longer be a strategic focus or target product of the capital market business , which would concentrate on fields with a high yield potential , such as customer business with share , interest and credit products and , to a lesser extent , ownaccount business , and would diminish still further in its importance .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In the future , investment banking will no longer be a strategic focus or a target product of the capital market business . The capital market business concentrates on areas with high earnings potential , such as the customer business with shares , interest rate and credit products and , to a lesser extent , proprietary trading and will continue to decrease in scope .


Iscover is taken to prevent blood clots ( thrombi ) forming in hardened blood vessels ( arteries ) , a process known as atherothrombosis , which can lead to atherothrombotic events ( such as stroke , heart attack , or death ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Iscover is used to prevent blood clots ( thrombi ) from forming in blood vessels ( arteries ) that have become rigid . This disease also called atherothrombosis can lead to the occurrence of atherothrombotic events ( such as stroke , heart attack , or death ) .


Isolated limb perfusion should be undertaken in specialised centres by surgical teams experienced in the management of limb sarcomas and ILP procedure , with an intensive care unit readily available and with the facilities for continuous monitoring for medicinal product leakage into the systemic circulation .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The isolated limb perfusion technique must be implemented in specialized centers , by teams experienced in the treatment of limb sarcomas and the ILP technique . These hospitals must have an intensive care unit and all the necessary equipment to continuously monitor and detect the passage of the drug into the systemic circulation .


It backs this up with extracts from the concession which emphasise generally the social and educational aims of Bioscope and with other extracts dealing more specifically with the prices to be charged for certain categories of visitor ( children accompanied by their parents , school groups , elderly people ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The French authorities back up their arguments with extracts from the concession , which highlight Bioscope's social and educational objectives . In other excerpts , reference is primarily made to the tariffs for certain groups of visitors ( children accompanied by their parents , school groups and senior citizens ) .


It has a very low potential to decrease mitochondrial DNA content , is not permanently incorporated into mitochondrial DNA , and does not act as an inhibitor of mitochondrial DNA polymerase gamma .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Lamivudine has a very low potential for reducing mitochondrial DNA content . It is not permanently incorporated into the DNA of mitochondria and does not act as a gamma polymerase antagonist in mitochondrial DNA .


It has seen the importance of identifying and focusing on core responsibilities; recognised the value of good communication systems; and become convinced of the need for performance goals and indicators and for transparency about that performance .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

He recognized the importance of good communication networks . Finally , he became aware of the need for objectives and performance indicators and of the need for transparency in this area .


It is generally considered inappropriate for weight-reducing drugs to be used during pregnancy , so women of childbearing potential should employ an adequate method of contraception while taking sibutramine and notify their physician if they become pregnant or intend to become pregnant during therapy .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The use of anti-obesity agents during pregnancy is generally considered inappropriate . Women of childbearing potential should therefore use an effective contraceptive method during treatment with sibutramine and notify their doctor if they become pregnant or want to become pregnant during treatment .


It is important to tell your doctor if you have had or have a serious heart condition ( see Take special care with Humira ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

It is important to tell your doctor if you have had severe heart problems .  ( see "Special precautions for use with Humira" ) .


It is necessary to set up a procedure to carry out technical amendments to the annexes to this Guideline in an effective manner , provided that such amendments neither change the underlying conceptual framework nor affect the reporting burden .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

It is necessary to develop a procedure for the efficient implementation of technical changes to the annexes to this guideline . However , these changes must neither change the underlying conceptual framework nor affect the reporting burden .


It is necessary to specify who may lodge a complaint and the information that such a complaint should contain; a complaint should be rejected where there is insufficient evidence of injury to proceed .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

It is necessary to specify who can file a complaint and what information the complaint should contain . A complaint must be rejected if damage has not been sufficiently proven .


It is not known whether TMZ is excreted in human milk; thus , breast-feeding should be discontinued while receiving treatment with TMZ .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

It is not known whether TMZ is excreted in human milk . Therefore , breast-feeding should be discontinued during treatment with TMZ .


It is not known whether measles or mumps vaccine virus is secreted in human milk; therefore , caution should be exercised when M-M-RVAXPRO is administered to a breast-feeding woman .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

It is not known whether the measles or mumps vaccine virus is excreted in breast milk . Also , special care is recommended when M-M-RVAXPRO is given to a nursing woman .


It is recommended that women do not breast-feed during treatment with Erbitux and for 2 months after the last dose , because it is not known whether cetuximab is excreted in breast milk .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

It is not known whether Erbitux is excreted in human milk . Breast-feeding is not recommended during treatment with Erbitux and for up to 2 months after the last administration .


It is unclear whether or not there is a direct association between pioglitazone and macular oedema but prescribers should be alert to the possibility of macular oedema if patients report disturbances in visual acuity; an appropriate ophthalmological referral should be considered .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

A direct relationship between pioglitazone and macular edema has not been clearly established . Prescribers should be warned , however , of the possible occurrence of macular edema in patients with visual acuity disorders; in this case , an ophthalmologic consultation should be considered .


It may occur if the insulin dose is too high in relation to the insulin requirement and therefore require special attention during dose intensification as outlined in section 4 . 2 .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

This occurs when the dose of insulin is too large for the insulin requirements . Particular attention is therefore required when intensifying the dosage as described in section 4 . 2 .


It was also claimed that , should the scheme be found to be countervailable , only actual excess remissions should be used as a basis for the calculation of the benefit , and the Commission should have examined whether there was in fact an excess drawback of import charges on inputs consumed in the production process .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Should the regulation nevertheless be regarded as contestable , only the actual excessive reimbursement of import duties should be used as the basis for calculating the benefit . The Commission should have examined whether there was in fact an excessive reimbursement of import duties on inputs used in production .


It was consequently concluded that the claim for an adjustment with regard to start-up costs was contradictory and not confirmed by any evidence and was therefore rejected .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

It was therefore concluded that the claim for an adjustment for start-up costs was contradicted by the facts and was not supported by any evidence . It was therefore rejected .


It was therefore considered that this particular product type was sold in insufficient quantities for the domestic prices to provide an appropriate basis for the establishment of the normal value and another method had to be applied .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

It was therefore concluded that sales of this product type were not sufficient to provide a suitable basis for the determination of normal value . A different method therefore had to be applied .


KIOVIG contains a wide variety of different antibodies , some of which can affect blood tests .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

KIOVIG contains a wide variety of different antibodies . Some can affect blood tests .


Kinzalkomb may increase the blood pressure lowering effect of other medicines and you should consult with your doctor if you need to adjust the dose of your other medicine while taking Kinzalkomb .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Kinzalkomb may increase the blood pressure lowering effect of other medicines . You should check with your doctor to see if the dose of these other medicines will need to be adjusted while you are taking Kinzalkomb .


Kivexa contains abacavir and lamivudine , therefore any interactions identified for these individually are relevant to Kivexa .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Kivexa contains abacavir and lamivudine . As such , the drug interactions observed for each of the two components can occur with Kivexa .


Lamivudine induces early embryolethality when administered to pregnant rabbits at exposure levels comparable to those achieved in man , but not in the rat even at very high systemic exposures .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Lamivudine induces early embryonic lethality in pregnant rabbits exposed to lamivudine concentrations comparable to those obtained in humans . This was not observed in female rats , even after very high systemic exposure .


Lapatinib is not significantly renally excreted and is highly bound to plasma proteins , therefore haemodialysis would not be expected to be an effective method to enhance the elimination of lapatinib .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Lapatinib is not significantly excreted in the kidneys and is highly bound to plasma proteins . Therefore , hemodialysis does not appear to be an effective method of promoting the elimination of lapatinib .


Less than 1% of dose-related material is excreted in urine and therefore renal impairment would not be expected to affect the pharmacokinetics of fluticasone furoate .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Less than 1% of the administered dose is excreted in the urine . Also , renal impairment is not expected to affect the pharmacokinetics of fluticasone furoate .


Lisonorm tablet contains 5mg amlodipine/ 10mg lisinopril and is an anti-hypertensive indicated in patients with blood pressure adequately controlled with lisinopril and amlodipine given concurrently at the same dose level .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Lisonorm tablet contains 5 mg amlodipine and 10 mg lisinopril . It is an antihypertensive drug indicated in patients whose blood pressure is adequately controlled by lisinopril and amlodipine given simultaneously at the same strength .


Local toxicity and sensitising potential was absent in animal studies , but slight irritating properties to the rabbit eye were identified .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

No sensitizing potential , nor local toxicity , was observed in animals . However , slight eye irritation was observed in the rabbit .


Lumiracoxib does not accumulate in plasma under once or twice daily administration and steady state is achieved on the first day of administration with no increase in Cmax or AUC after extended dosing .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Lumiracoxib does not accumulate in plasma on repeated once or twice daily administration . Steady state is achieved on the first day of administration , with no subsequent increase in Cmax or AUC after prolonged administration .


Luveris should not be administered as a mixture with other medicinal products , in the same injection , except follitropin alfa for which studies have shown that co-administration does not significantly alter the activity , stability , pharmacokinetic nor pharmacodynamic properties of the active substances .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Luveris must not be mixed in the same syringe with other medicines , except with follitropin alfa . Studies have shown that the simultaneous administration of these two drugs does not significantly alter the activity , stability , pharmacokinetics or pharmacodynamics of their active substances .


MRLs for pesticides should be kept under review and may be changed to take account of new information and data .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The maximum residue levels for pesticides should be constantly monitored . They can be changed to reflect new information and dates .


Many of these patients had signs of local infection including osteomyelitis , and the majority of the reports refer to cancer patients following tooth extractions or other dental surgeries .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Many of them showed signs of local infection including osteomyelitis . The majority of cases involve cancer patients who have had tooth extraction or other dental surgeries .


Meanwhile , the Commission will pay particular attention to the import prices of urea originating in Russia and the attention of the customs authorities is drawn to this issue .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

For now , the Commission will pay particular attention to the import prices of urea originating in Russia . The attention of the customs authorities is drawn to this problem .


Meetings with interested parties , including industry representatives , have taken place on a quarterly basis and bilateral meetings with FEDESA , also on a quarterly basis , have provided an excellent forum for frank and in-depth discussions on the issues of the day .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Meetings with interested parties , including industry representatives , were held quarterly . Bilateral meetings with FEDESA , also on a quarterly basis , provided an excellent forum for frank and in-depth discussions on the issues of the day .


Member States shall bring into force the laws , regulations and administrative provisions necessary to comply with this Directive before 8 April 2001 and shall forthwith inform the Commission thereof .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Member States shall bring into force the laws , regulations and administrative provisions necessary to comply with this Directive before 8 April 2001 . They shall immediately inform the Commission thereof .


Member States shall bring into force the laws , regulations and administrative provisions needed in order to comply with this Directive by 31 July 1993 , except for railways for which the date of implementation will be decided later .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Member States shall adopt the laws , regulations and administrative provisions necessary to comply with this Directive by 31 July 1993 . This does not apply to transport by rail , for which the application date will be set at a later date .


Member States shall check whether the undertaking referred to in Article 3 ( 2 ) has been fulfilled , by periodic on-the-spot inspections in such a way that each holding is inspected at least every five years .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Member States shall ensure that the commitment referred to in Article 3 ( 2 ) is fulfilled . To this end , they carry out regular on-the-spot checks in such a way that each holding is inspected at least every five years .


Member States shall have 22 days to forward their written observations on the draft decision to the Commission; however , if a decision has to be taken urgently , a shorter time-limit may be set by the Chairman according to the degree of urgency involved .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Member States have twenty-two days to communicate to the Commission their written observations on the draft decision . However , in cases where the decision-making is of an urgent nature , a shorter deadline may be set by the president depending on the urgency .


Member States shall take appropriate and practicable measures to reduce the risk of transmission of avian influenza from birds living in the wild to susceptible birds kept in zoos , taking into account the criteria and risk factors set out in Annex I .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Member States shall take appropriate and practicable measures to prevent the risk of transmission of avian influenza virus from wild wild birds to susceptible zoo birds . In doing so , they take into account the criteria and risk factors specified in Annex I .


Member States which can demonstrate , after the Directive has been brought into force , that there are substantial problems for the operation of their small isolated systems , may apply for derogations from the relevant provisions of Chapters IV , V , VI , VII , as well as Chapter III , in the case of micro isolated systems , as far as refurbishing , upgrading and expansion of existing capacity are concerned , which may be granted to them by the Commission .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Member States which can demonstrate , after the entry into force of this Directive , that there are significant management problems for their small isolated networks , may request derogations from the relevant provisions of Chapters IV , V , VI and VII and , for micro isolated systems , Chapter III with with a view to refurbishing , improving and increasing existing capacity . The Commission may grant them such derogations .


Mimpara should be used with caution in patients with moderate to severe hepatic impairment and treatment should be closely monitored during dose titration and continued treatment ( see sections 4 . 4 and 5 . 2 ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Mimpara should be used with caution in patients with severe or moderate hepatic impairment . Close monitoring should be performed during the dose adjustment phase and during the maintenance phase of treatment ( see sections 4 . 4 and 5 . 2 ) .


Most patients treated with Zevalin experience a severely reduced number of blood cells , which needs some time to normalise again after treatment .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Most patients treated with Zevalin have experienced a severe decrease in the number of blood cells . It takes some time for this to normalize after treatment .


Naxcel should be handled with care and all the recommended precautions be taken to avoid exposure to the product .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Naxcel should be handled with care . All recommended precautions should be followed exactly to avoid direct exposure to the product .


Neupopeg contains less than 1 mmol ( 23 mg ) sodium per 6 mg dose , i . e . essentially sodium-free .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

in Neupopeg contains less than 1 mmol ( 23 mg ) sodium per 6 mg dose .  It is therefore practically free of sodium .


No dose recommendation can be given for the co- administration of amprenavir and Kaletra , but close monitoring is advised because the safety and efficacy of this combination is unknown .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

No dosage recommendation can be made when amprenavir and Kaletra are co-administered . Close monitoring is recommended , as the efficacy and safety of this combination are not known .


No effects were observed in dogs; however in rats , there was an apparent dose-dependent decrease in total and free T4 that was more consistent in the female .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

No effects were seen in dogs . However , an apparent dose-related drop in free and total T4 levels was observed in rats , especially females .


No management company may engage in activities other than the management of UCITS authorised according to this Directive except the additional management of other collective investment undertakings which are not covered by this Directive and for which the management company is subject to prudential supervision but which cannot be marketed in other Member States under this Directive .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The activities of the management company should be limited to the management of UCITS authorized in accordance with this Directive . This does not preclude that they may additionally engage in the management of other collective investment undertakings not covered by this Directive and whose management company is subject to prudential supervision but whose units cannot be marketed in other Member States under this Directive .


No modification of the apparatus or the grading method may be authorised except by means of a new Commission Decision adopted in the light of experience gained; for this reason , the present authorisation may be revoked .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

No modification of the apparatus or of the grading method can be authorized except by a new Commission decision adopted in the light of experience gained . For this reason , this authorization may be revoked .


No pig may leave the holding before the negative results of the serological tests are available; if none of the pigs has developed antibodies against African swine fever virus , full repopulation may then take place;
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

No pig may leave the farm before the negative results of the serological tests are available . If no antibodies against the ASF virus have developed in any of the pigs , they can be fully replenished .


No studies on the effects on the ability to drive and use machines have been performed; however erlotinib is not associated with impairment of mental ability .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The effects on the ability to drive and use machines have not been studied . However , treatment with erlotinib is not associated with impaired higher functions .


No treatment was given for the majority of injection site reactions in the Enbrel treatment groups , and the majority of patients who were given treatment received topical preparations such as corticosteroids , or oral antihistamines .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The majority of injection site reactions in the groups treated with Enbrel did not require treatment . The majority of patients who received treatment received topical preparations such as corticosteroids , or oral antihistamines .


None of the degarelix-treated patients experienced a testosterone surge; there was an average decrease of 94% in testosterone at day 3 .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

None of the patients treated with degarelix experienced peak testosterone secretion . An average decrease of 94% in testosterone concentration was observed on D . 3 .


Notification shall be made even where no application has been submitted in a Member State: it shall state that no submission has been received within the period referred to in Article 4 ( 3 ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

A communication must be made even if no request has been made in a Member State . This must indicate that no request has been received within the time limit referred to in Article 4 ( 3 ) .


Notifications shall be made in writing and must reach the competent authority at least 48 hours before the day on which the operation is to take place .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Statements are made in writing . They must reach the competent authority at least 48 hours before the day of the operation .


OPTISON is a transpulmonary echocardiographic contrast agent for use in patients with suspected or established cardiovascular disease to provide opacification of cardiac chambers , enhance left ventricular endocardial border delineation with resulting improvement in wall motion visualisation .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

OPTISON is a pulmonary capillary bed echocardiography contrast medium used in patients with known or suspected cardiovascular disease . It allows the ultrasound opacification of the heart chambers , obtaining a better definition of the left ventricular endocardial relief , hence better visualization of the wall kinetics .


On 11 July 2002 the Romanian authorities provided the revised list of eligible expenditure in conformity with Article 4 ( 1 ) , Section B of the MAFA , and this did not give rise to objections by the Commission .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

On 11 July 2002 , the Romanian authorities provided the revised list of eligible expenditure in accordance with Article 4 ( 1 ) , section B , of the CFP . The Commission did not raise any objections to this list .


On 15 November 2004 the Council adopted Decision 2004/767/CFSP [2] , which amended the list contained in the Annex to Common Position 2004/694/CFSP .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

On 15 November 2004 , the Council adopted Decision 2004/767 / CFSP [2] . In that decision , the list in the Annex to Common Position 2004/694 / CFSP was amended .


On 17 May 2006 , CIS bio international has officially notified the Committee for Medicinal Products for Human Use ( CHMP ) that they wish to withdraw their application for a marketing authorisation for SCINTIMUN , for diagnostic imaging to determine the location of infectious or inflammatory lesions and to detect metastases ( when cancer spreads ) in bone marrow .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

On May 17 , 2006 , CIS bio international officially informed the Committee for Medicinal Products for Human Use ( CHMP ) of its decision to withdraw its application for marketing authorization for the product SCINTIMUN . The claimed indication was for the determination of the location of infectious or inflammatory lesions and the detection of metastases ( when cancer has spread ) in the bone marrow by diagnostic imaging .


On 26 March 2007 , Insmed Europe Ltd officially notified the Committee for Medicinal Products for Human Use ( CHMP ) that it wishes to withdraw its application for a marketing authorisation for IPLEX , for the treatment of patients with primary growth hormone insensitivity and of patients with growth hormone gene deletion who have developed neutralising antibodies to growth hormone .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

On March 26 , 2007 , Insmed Europe Ltd officially informed the Committee for Medicinal Products for Human Use ( CHMP ) of its decision to withdraw its marketing authorization application for IPLEX . The requested indication related to the treatment of patients with primary insensitivity to growth hormone and patients with a deletion of the growth hormone gene and who have developed neutralizing antibodies against the hormone . growth .


On 6 January 2004 , the Commission received a request pursuant to Article 23 ( 2 ) of the basic Regulation ( the request ) from the Community producers DuPont Teijin Films , Mitsubishi Polyester Film GmbH and Nuroll SpA ( the applicants ) to investigate the alleged circumvention of the countervailing measures imposed on imports of PET film originating in India .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

On 6 January 2004 the Commission received a request pursuant to Article 23 ( 2 ) of the Basic Regulation ( hereinafter referred to as "the request" ) to investigate alleged circumvention of the countervailing measures imposed on imports of PET film originating in India . The application was submitted by the joint producers DuPont Teijin Films , Mitsubishi Polyester Film GmbH and Nuroll SpA ( hereinafter referred to as "the applicant" ) .


On a unitary board , one way to ensure this is that the roles of chairman and chief executive are separate; in the case of unitary and dual boards , one option may be that the chief executive does not immediately become the chairman of the ( supervisory ) board .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In a unified management body ( board of directors ) one of the possible ways of ensuring this is that the duties of the chairman and the general manager responsible for the management are separated from one another . Another option could be that the general director responsible for the management or ( in the two-tier system ) the chairman of the board does not immediately take over the post of chairman of the board of directors / supervisory board .


On the basis of the mission report and further information provided by the Slovakian Competent Veterinary Authorities , the health status of swine in Slovakia appears to be satisfactory as regards classical swine fever in domestic swine; however , there are a number of designated areas where infection exists in wild boars .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

On the basis of the mission report and the information provided by the competent Slovak authorities , it appears that the health status of pigs in Slovakia , with regard to classical swine fever in domestic pigs , is satisfactory . However , in some areas infection exists in wild boars .


On the business side , negotiations to obtain the best possible service from both hotels and travel organisations will have a high priority as these costs form a large share of EMEAs budget .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

In terms of management , priority will be given to negotiations with hotels and travel agencies in order to obtain the best possible conditions . These costs indeed constitute an important part of the EMEA budget .


On written request the Member State concerned shall provide the Commission , within a period of 20 working days , or such longer period as may be fixed in the request , with all the information that the Commission considers necessary for assessing whether the conditions of this Regulation have been complied with , in particular the total amount of de minimis aid received by any enterprise .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

At the Commission's written request , the Member State concerned shall provide the Commission with all the information it needs to assess whether the conditions of this Regulation have been complied with within twenty working days or a longer period specified by it in the request for information . This information includes in particular the total amount of aid that a company has received under the de minimis rule .


On-the-spot checks of areas , as a general rule , consist of two parts , the first of which relates to verifications and measurements of declared agricultural parcels on the basis of graphic material , aireal photography and so forth .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

On-the-spot checks of areas generally consist of two parts . The first part consists of a verification and measurement of the declared agricultural parcels by means of graphic material , aerial photographs , etc .


Once the general debate has been concluded , any Member may give an oral explanation on the final vote for not longer than one minute or give a written explanation of no more than 200 words , which shall be included in the verbatim report of proceedings .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

When the general discussion is over , each deputy may make an oral statement of no more than one minute or a written statement of no more than 200 words on the final vote . The statement is included in the verbatim report of the discussions .


Only one address should preferably be indicated for each party to proceedings; where several addresses are indicated , only the address mentioned first shall be taken into account , except where the party to proceedings designates one of the other addresses as an address for service .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

If possible , only one address should be given for each party involved . If there are more than one address , only the first named will be taken into account , unless the party involved in the proceedings gives one of the other addresses as the address for service .


Osteoporosis Osteoporosis is a disease that involves the thinning and weakening of the bones and is common in women after the menopause , but can also occur in men .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Osteoporosis Osteoporosis is a disease causing thinning and weakening of the bones . It is common in women after menopause but can also occur in men .


Other antihypertensive agents may increase the hypotensive effects of irbesartan; however Irbesartan Krka has been safely administered with other antihypertensive agents , such as beta-blockers , long- acting calcium channel blockers , and thiazide diuretics .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Other antihypertensive agents may increase the hypotensive effects of irbesartan . However Irbesartan Krka has been used without problems with other antihypertensive drugs such as beta-blockers , long-acting calcium channel blockers and thiazide diuretics .


Other oncogenic HPV types can also cause cervical cancer and therefore routine cervical screening remains critically important and should follow local recommendations .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Other types of oncogenic HPV can also be responsible for cervical cancer . Therefore routine screening for cervical cancer remains very important and should be done according to local recommendations .


PBPC mobilisation should be considered only in donors who meet normal clinical and laboratory eligibility criteria for stem cell donation with special attention to haematological values and infectious disease .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Mobilization of PSCs can only be considered in donors who meet the clinical and biological criteria retained for the donation of stem cells . Particular attention should be paid to haematological values and infectious diseases .


PK/ PD relationship was observed between stomatitis and AUCs in autologous patients and between bilirubin increase and AUCs in a combined autologous and allogeneic patient analysis .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

A PK / PD relationship was observed between the severity of stomatitis and the increase in AUCs in autologous patients . A combined analysis of autograft and allogeneic patients showed a PK / PD relationship between the increase in total plasma bilirubin and that in AUCs .


Panretin is applied twice a day to the skin lesions , avoiding healthy skin , using enough gel to cover each lesion with a generous coating , then left to dry for three to five minutes before covering with clothing .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Panretin should be applied to the skin lesions twice a day , avoiding healthy skin and using a sufficient amount of the gel so that each lesion is covered with a thick layer . The gel should be allowed to dry for three to five minutes before putting on a garment .


Panretin is usually applied for up to 12 weeks at first , and treatment continued after this period only on lesions which have responded to treatment .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

It is recommended that Panretin be applied for an initial period of up to 12 weeks . At the end of this period , treatment is continued only on lesions that have responded to treatment .


Patients aged 4 to 17 years with moderately to severely active polyarticular juvenile idiopathic arthritis refractory to or intolerant of methotrexate were enrolled; patients remained on a stable dose of a single nonsteroidal anti- inflammatory drug and/ or prednisone ( 0 . 2 mg/ kg/ day or 10 mg maximum ) .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The patients included in the study were aged 4 to 17 years with moderate to severe polyarticular juvenile idiopathic arthritis , refractory or intolerant to methotrexate . A stable dose of a single nonsteroidal anti-inflammatory drug and / or prednisone ( <0 . 2 mg / kg / day or maximum 10 mg ) has been maintained in patients .


Patients and their carers must be instructed that Effentora contains an active substance in an amount that can be fatal to a child , and therefore to keep all tablets out of the reach and sight of children .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

It is imperative to inform patients , caregivers that Effentora contains an active substance in a dose which can be fatal to a child . They should therefore keep all tablets out of the reach and sight of children .


Patients must undergo appropriate thyroid blocking treatment prior to injection to minimise thyroid uptake of radioactive iodine , for example by oral administration of approximately 120 mg potassium iodide 1-4 hours prior to injection and again 12-24 hours post-injection of DaTSCAN .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

Before administration , the patient should undergo treatment that blocks the uptake of iodine by the thyroid gland in order to reduce the uptake of radioactive iodine . This can , for example , be done by oral administration of approximately 120 mg of potassium iodide , 1 to 4 hours before and again 12 to 24 hours after the injection of DaTSCAN .


Patients received two 1000 mg intravenous infusions of MabThera , each following an intravenous infusion of 100 mg methylprednisone and separated by an interval of 15 days .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:

The patients received two 1000 mg intravenous infusions of MabThera , 15 days apart . These infusions were each preceded by an intravenous infusion of 100 mg of methylprednisolone .