passages.id: split_8_test_2911_passage
passages.type: progene_text
passages.text: Here we demonstrate that the expression of APP - CTs [ C31 , AICD ( C59 ) and C99 ] induces increases in acetylation of histone 3 and histone 4 and that treatment with sodium butyrate , an inhibitor of histone deacetylase , significantly enhances the cytotoxicity induced by APP - CTs .