passages.id: split_8_test_2881_passage
passages.type: progene_text
passages.text: Although the 11R oxygenation was not perturbed , changing Leu-384 ( into Phe , Trp ) , Trp-387 ( Phe , Tyr ) , Phe-518 ( Ile , Trp , Tyr ) , and Gly-526 ( Ala , Ser , Thr , Val ) impaired or abrogated PGG2 synthesis , and typically 11R-HETE was the main product formed .