passages.id: split_8_test_2910_passage
passages.type: progene_text
passages.text: In this study , based on the hypothesis that APP - CTs might exert neurotoxicity by inducing some gene transcription , we investigated the effects of APP - CTs on histone acetylation which indicates that transcription is actively going on and also on the relationship between histone acetylation and the cytotoxicity induced by APP - CTs in nerve growth factor ( NGF ) - differentiated PC12 cells and rat primary cortical neurons .