passages.id: split_8_test_497_passage
passages.type: progene_text
passages.text: In an attempt to reduce the incidence of NSAID - induced gastrointestinal lesions , the following approaches have been proposed : (i) use of the prostaglandin analogue misoprostol , which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID - induced gastric and duodenal ulcers as in the reduction of serious upper gastrointestinal complications ; (ii) histamine H2 receptor antagonists ( H2 antagonists ) , e.g. ranitidine , cimetidine and famotidine , which are useful in the prevention of NSAID - induced duodenal ulcers during long term treatment , but not in the prevention of NSAID - induced gastric ulcers ; (iii) proton pump inhibitors , e.g omeprazole , and pantoprazole , whose efficacy in preventing NSAID - associated ulcers has been recently demonstrated ; and (iv) barrier agents , e.g. sucralfate , which cannot be recommended as prophylactic agents to prevent NSAID - induced gastropathy .