passages.id: split_8_test_338_passage
passages.type: progene_text
passages.text: We previously described a control element in the granulocyte - macrophage colony - stimulating factor ( GM-CSF ) enhancer that is necessary and sufficient to mediate both transcriptional activation in response to T-cell stimuli and transcriptional repression by 1,25-dihydroxyvitamin D3 [ 1,25(OH)2D3 ] through the vitamin D3 receptor ( VDR ) .