passages.id: split_8_test_891_passage
passages.type: progene_text
passages.text: JNK is activated by JNK - activating kinase ( JNKK1 and JNKK2 ) , a subfamily of the dual specificity MAP kinase kinase ( MEK ) family , through phosphorylation on threonine ( Thr ) 183 and tyrosine ( Tyr ) 185 residues .