passages.id: split_8_test_3199_passage
passages.type: progene_text
passages.text: Small - to - large substitutions ( G207A , G207T , G207M , G207L , G207F , and G207W ) resulted in loss of the octaketide - forming activity and concomitant formation of shorter chain length polyketides ( from triketide to heptaketide ) including a pentaketide chromone , 2,7-dihydroxy-5-methylchromone , and a hexaketide pyrone , 6-(2,4-dihydroxy-6-methylphenyl)-4-hydroxy-2-pyrone , depending on the size of the side chain .