passages.id: split_8_test_2023_passage
passages.type: progene_text
passages.text: Here we show that expression of BCR - ABL in myeloid precursor cells leads to transcriptional suppression of the granulocyte colony - stimulating factor receptor G-CSF-R ( encoded by CSF3R ) , possibly through down - modulation of C / EBPalpha - the principal regulator of granulocytic differentiation .