passages.id: split_8_test_959_passage
passages.type: progene_text
passages.text: Simultaneous investigation of both TSC genes in a group of 48 unassigned TSC patients , which were previously tested to exclude large intragenic TSC2 rearrangements , revealed aberrant migrating polypeptides resulting from truncating mutations in nine TSC1 cases and in 16 TSC2 cases while three TSC2 cases showed enlarged proteins .