passages.id: split_8_test_2243_passage
passages.type: progene_text
passages.text: Experiments with PC12 cells transfected with the full - length THRP cDNA and grown in the presence or absence of a tyrosine kinase inhibitor , along with experiments where PC12 cells were cotransfected with the THRP cDNA with or without the wild - type or mutant ( tyrosine kinase deficient ) c - Abl cDNA , showed that THRP is tyrosine phosphorylated ; however , it is not a substrate for c-Abl .