passages.id: split_8_test_2604_passage
passages.type: progene_text
passages.text: Diverse apoptotic stimuli release holocytochrome c from mitochondria , allowing holocytochrome c to bind apoptotic protease activating factor-1 ( Apaf-1 ) , which in turn binds caspase-9 both activating this caspase and forming an Apaf-1 / caspase-9 holoenzyme .