passages.id: split_8_test_2480_passage
passages.type: progene_text
passages.text: EGF increased the tyrosine phosphorylation of several proteins ( the EGF receptor , insulin receptor substrate ( IRS ) - 1 , IRS-2 , and Grb2 - associated binder 1 ) , whereas Shc and Gab2 were only weakly and inconsistently phosphorylated .