passages.id: split_8_test_3232_passage
passages.type: progene_text
passages.text: Intracellular Ca(2+) triggered the activation of mitogen - activated protein kinase ( MAPK ) in HMC-1 , especially p42 and p44 isoforms of extracellular signal - regulated kinase ( ERK ) and p38 MAPK , but not c-Jun N - terminal kinase ( JNK ) .