passages.id: split_8_test_1428_passage
passages.type: progene_text
passages.text: Point mutations in the amino terminus domain ( Asp9 and Glu12 ) and the first extracellular loop ( Lys108 , Asn110 , and Lys120 ) of CXCR2 reduced cell activation to all three ligands as measured by changes in intracellular calcium concentration .