passages.id: split_8_test_2486_passage
passages.type: progene_text
passages.text: Both insulin and EGF increase the tyrosine phosphorylation and activation of IRS-1 and IRS-2 , whereas EGF is also capable of activating additional PI 3-kinase pools and , thus , can augment the downstream signaling of insulin in insulin - resistant states like Type 2 diabetes .