passages.id: split_8_test_3462_passage
passages.type: progene_text
passages.text: We have shown previously that one of the TPR subunits of the Drosophila APC / C , Apc3 ( also known as Cdc27 or MÃ?Â¡kos ) , is essential for development , and perturbation of its function results in mitotic cyclin accumulation and metaphase - like arrest .