passages.id: split_8_test_1418_passage
passages.type: progene_text
passages.text: To test this hypothesis , we performed a deletion analysis of X11alpha effects on metabolism of APP ( 695 ) Swedish ( K595N / M596L ) ( APP (sw) ) by transient cotransfection of HEK 293 cells with : 1 ) X11alpha ( X11alpha - wt , N - MID - CID - PTB - PDZ - PDZ - C ) , 2 ) amino - terminal deletion ( X11alpha - DeltaN , PTB - PDZ - PDZ ) , 3 ) carboxyl - terminal deletion ( X11alpha - DeltaPDZ , MID - CID - PTB ) , or 4 ) deletion of both termini ( PTB domain only , PTB ) .