passages.id: split_8_test_419_passage
passages.type: progene_text
passages.text: By mutational analysis it was previously established that this repression is consistent with EBNA3C being targeted to Cp by binding the cellular sequence - specific DNA - binding protein CBF1 ( also known as recombination signal - binding protein [RBP]-Jkappa. Further analysis suggested that in vivo a corepressor interacts with EBNA3C in this DNA binding complex. Results presented here are all consistent with a component of such a corepressor exhibiting histone deacetylase activity. The drug trichostatin A , which specifically inhibits histone deacetylases , relieved two - to threefold the repression of Cp induced by EBNA3C in two different cell types .