passages.id: split_8_test_2466_passage
passages.type: progene_text
passages.text: To investigate the myelin sheath formation in shiverer mutant mice resulting from the absence of compact myelin , firstly we developed new methods for generating oligodendrocyte precursor cells ( OPCs ) from an E17 mouse brain , and examined homozygous shiverer ( shi / shi ) OPCs with respect to myelinogenesis in vitro .