passages.id: split_8_test_1424_passage
passages.type: progene_text
passages.text: The objective of this investigation was to determine the amino acid residues of the human neutrophil CXC chemokine receptor-2 ( CXCR2 ) that are critical for binding the ligands interleukin 8 ( IL-8 ) , neutrophil - activating peptide-2 ( NAP-2 ) , and growth - related protein alpha ( GROalpha ) and critical for receptor - mediated signal transduction .