passages.id: split_8_test_1014_passage
passages.type: progene_text
passages.text: WR-1065 is rapidly formed from WR-2721 and equilibrates between plasma and blood cells ; ( 2 ) WR - 1065 decays in plasma and blood cells with similar rapid initial half - lives of approximately 16 min ; (3) WR-2721 treatment increases cysteine in plasma and blood cells , an effect similar to that of mesna ; (4) WR-2721 treatment appears to increase glutathione levels in blood cells ; (5) Mesna does not have a substantial effect on the fate of WR-2721 in patients .