passages.id: split_6_test_1152_passage
passages.type: progene_text
passages.text: These apical signals are translated into basolateral events that are recognized by cells in the interstitium , such as the basolateral secretion of the C - C - chemokines MCP-1 and RANTES , which may ( via macrophages ) stimulate interstitial myofibroblasts , and thus lead to accumulation of extracellular matrix proteins and progressive interstitial fibrosis .