passages.id: split_6_test_108_passage
passages.type: progene_text
passages.text: In HeLa cells , sustained PDT - induced JNK1 and p38 mitogen - activated protein kinase ( MAPK ) activations overlap the activation of a DEVD - directed caspase activity , poly(ADP-ribose ) polymerase ( PARP ) cleavage , and the onset of apoptosis .