passages.id: split_6_test_804_passage
passages.type: progene_text
passages.text: The dominant negative form of MAPKAP-K3 , a downstream kinase activated by p38 MAPK , and the dominant negative form of cAMP - response element - binding protein , inhibited the reporter gene activation by IGF-I and p38beta MAPK significantly ( p < 0.01 ) .