passages.id: split_6_test_3129_passage
passages.type: progene_text
passages.text: Activation of p38 MAPK pathway was required for TGF-beta - induced cell migration , invasion and MMP-2 / - 9 up - regulation , indicating a critical role of p38 MAPK signaling in TGF-beta - promoted tumor progression of H-ras - activated cells .