passages.id: split_6_test_618_passage
passages.type: progene_text
passages.text: Interleukin-4 ( IL-4 ) and IL-10 , belonging to Th2 , and transforming growth factor - beta ( TGF-beta ) , belonging to T regulatory ( Tr ) 1 cytokines , are known to suppress the development of NK , NK T cells , as well as CTLs and to block Th0 cell differentiation to Th1 cells , suggesting that tumor cells can evade the innate and acquired immunity by virtue of cells producing these inhibitory cytokines .