passages.id: split_6_test_2002_passage
passages.type: progene_text
passages.text: The administration of the reference formulation resulted in a particularly high interindividual variability of pharmacokinetic parameters , with low exposure to compound RR01 ( AUC0-48h of 6.5 microg x h / mL and coefficient of variation ( CV ) of 116 % ) and much higher Tmax , as compared to both pH - sensitive formulations .