passages.id: split_6_test_2569_passage
passages.type: progene_text
passages.text: The inactivated X chromosomes are covered with Xist ( X - inactive specific transcript ) RNA , and also enriched with the histone H2A variant , macroH2A1.2 . The N-terminal one - third of macroH2A1.2 is homologous to core histone H2A , but the function of the C - terminal two - thirds , which contains a basic , putative leucine zipper domain , remains unknown.In this study , we tried analyzing protein - protein interaction with a yeast two - hybrid system to interact with the nonhistone region of mouse macroH2A1.2 .