passages.id: split_6_test_407_passage
passages.type: progene_text
passages.text: Fine mapping by functional analysis of HSF1 - HSF2 chimeras and point mutagenesis revealed that a small region in the amino - terminal portion of the HSF1 linker is required for maintenance of HSF1 in the monomeric state in both yeast and in transfected human 293 cells .