passages.id: split_6_test_101_passage
passages.type: progene_text
passages.text: Because HBx binds to TFIIH - associated proteins , we propose that HBx may interfere with the NER pathway also through binding to and altering the activities of helicases necessary for NER and , thereby , increase the mutation rate induced by chemical carcinogens , such as aflatoxin B1 , during human liver carcinogenesis .