passages.id: split_6_test_3188_passage
passages.type: progene_text
passages.text: Furthermore , a marked reduction in procollagen and TGF-beta synthesis was observed in TNFR-1 KO mice , which also had little detectable NF-kappa B , STAT3 , and AP1 binding , and reduced levels of liver interleukin-6 ( IL-6 ) mRNA compared to WT and TNFR-2 KO mice .