passages.id: split_6_test_501_passage
passages.type: progene_text
passages.text: Strikingly , Gab2 has an inhibitory effect on the activation of Elk-1 - dependent transcription triggered by a dominant active Ras mutant ( RasV12 ) or under growth factor stimulation , whereas Gab1 acts to potentiate slightly the Elk-1 activity in the same system .