passages.id: split_6_test_3451_passage
passages.type: progene_text
passages.text: Our data are consistent with the concepts that LCAT activity : 1 ) is essential for developing large , spherical , apoA-I - containing HDL and for the formation of normal - sized apoC-I and apoC-III HDL ; and 2 ) has little affect on the conversion of prebeta-1 into alpha-4 HDL , only slight effects on apoE HDL , and no effect on apoA-IV HDL particles .