passages.id: split_6_test_1306_passage
passages.type: progene_text
passages.text: In a B-cell line that fails to elevate cAMP , attenuate NRE - binding protein ( NRE-BP ) activity or express CD25 following IL-4 treatment , stimulation of cAMP accumulation by forskolin facilitates IL-4 - mediated induction of both the endogenous gene and an exogenous reporter gene under the control of a minimal promoter / enhancer fragment of the CD25 gene .