passages.id: split_6_test_1471_passage
passages.type: progene_text
passages.text: To elucidate the possible involvement of angiotensin II ( AII ) in the pathogenesis of microvascular changes in severe hypertension , we investigated the effects of angiotensin II type 1 ( AT1 ) receptor antagonist and angiotensin - converting enzyme inhibitor ( ACEI ) on the expression of adhesion molecules of leukocytes and brain microvessels .