passages.id: split_6_test_1138_passage
passages.type: progene_text
passages.text: The present in vivo and in vivo experiments were performed to test the hypothesis that in rats with glomerular proteinuria , the bioactive growth factors transforming growth factor - beta ( TGF-beta ) and hepatocyte growth factor ( HGF ) are ultrafiltered into tubular fluid , can interact with respective receptors in apical tubular cell membranes , increase the expression and basolateral secretion of C - C - chemokines , which interact with cells in the renal interstitium and indirectly cause myofibroblasts to increase the expression of extracellular matrix proteins .