passages.id: split_5_test_2412_passage
passages.type: progene_text
passages.text: Mechanistic studies with human cells indicated two modes of FGF-10 action : (i) translocation of rFGF - 10 into urothelial cell nuclei and (ii) a signaling cascade that begins with the heparin - dependent phosphorylation of tyrosine residues of surface transmembrane receptors .