passages.id: split_5_test_559_passage
passages.type: progene_text
passages.text: Together with the activity of mutant VP16 proteins , the structure of free VP16 suggests that it contains (1) a disordered carboxy - terminal region that associates with HCF , Oct-1 , and DNA in the VP16 - induced complex , and ( 2 ) a structured region involved in virion assembly and possessing a novel DNA - binding surface that differentiates among TAATGARAT VP16 - response elements .