passages.id: split_5_test_1045_passage
passages.type: progene_text
passages.text: RepA was shown to bind to these sites quite differently , binding primarily as a monomer or dimer to BD-1 to initiate RepA transcription and plasmid replication , and as higher oligomers to BD-2 to autoregulate repA transcription , the balance being reflected in plasmid copy number .