passages.id: split_5_test_1727_passage
passages.type: progene_text
passages.text: Three open - label , randomized , two - sequence , multiple - dose studies having the same design ( 7 days of APV or RTV alone followed by 7 days of both drugs together ) used 450 or 900 mg APV with 100 or 300 mg RTV every 12 h with pharmacokinetic assessments on days 7 and 14 .