passages.id: split_5_test_1212_passage
passages.type: progene_text
passages.text: Although actin has been implicated in vesicle trafficking , and rafts are sites of active phosphoinositide and tyrosine kinase signaling that mediate apically directed vesicle trafficking , it is not known whether phosphoinositide regulation of actin dynamics occurs in rafts , or if it is linked to vesicle movements .