passages.id: split_5_test_103_passage
passages.type: progene_text
passages.text: Using this cell model , we demonstrate that the induced expression of p202 in asynchronous cultures of these cells was accompanied by : (a) an increase in steady - state levels of p21 ( WAF1 / CIP1 / SDI1 ) ( p21 ) mRNA and protein ; (b) a decrease in Cdk2 protein kinase activity ; and (c) an increase in the functional form of retinoblastoma protein ( pRb ) .