passages.id: split_5_test_2507_passage
passages.type: progene_text
passages.text: In the present study , both the soluble human IL-18 ligand binding alpha chain ( sIL-18Ralpha ) and the sIL-18Rbeta chain were investigated for inhibition of IL-18 - induced interferon-gamma ( IFN-gamma ) production in human peripheral blood mononuclear cells ( PBMC ) , whole blood , and KG-1 macrophage and natural killer ( NK ) cell lines .