passages.id: split_5_test_49_passage
passages.type: progene_text
passages.text: In a previously validated case - control study from Northern Ireland , consisting of 95 patients with insulin - dependent ( type 1 ) diabetes and nephropathy ( cases ) and 96 patients with insulin - dependent ( type 1 ) diabetes without nephropathy ( controls ) , the authors performed PCR - based genotyping of specific DNA polymorphisms within the interleukin 1A , interleukin 1B , interleukin 1 ( type 1 ) receptor and interleukin 1 receptor antagonist genes .