passages.id: split_5_test_2945_passage
passages.type: progene_text
passages.text: Ectopic expression of the CREB - binding protein ( CBP ) histone acetyltransferase ( HAT ) stimulated plasmid - based ORF50 transcription in a HAT - dependent manner , suggesting that CBP recruitment to the ORF50 promoter can be an initiating event for transcription and viral reactivation .