passages.id: split_5_test_236_passage
passages.type: progene_text
passages.text: In budding yeast , the protein Skp1p , the cullin - family member Cdc53p , and the F-box / WD - repeat protein Cdc4p form the SCFCdc4p ubiquitin ligase complex , which targets the cyclin - dependent kinase ( Cdk ) inhibitor Sic1p for proteolysis [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] .