passages.id: split_5_test_2886_passage
passages.type: progene_text
passages.text: When bone marrow from IFN-gamma ( -/- ) B6 mice was transplanted into lethally irradiated IFN-gamma ( +/+ ) B6 mice , the level of IFN-gamma mRNA expression in the skin or peripheral blood mononuclear cells ( PBMCs ) of recipient mouse was markedly reduced , suggesting that IFN-gamma is normally produced by bone marrow - derived cells .