passages.id: split_5_test_114_passage
passages.type: progene_text
passages.text: The present study also showed that the substitutions of glutamic acid at 42 for aspartic acid and leucine at 44 for phenylalanine in the first potent alpha-helix structure of RRM1 , as were seen in another ELAV - like protein Hel-N1 , markedly affected the RNA binding .