passages.id: split_5_test_3406_passage
passages.type: progene_text
passages.text: Our previous report has shown that Irsogladine maleate ( IM ) counters and obviates the reduction in gap junction intercellular communication ( GJIC ) and the increase in IL-8 levels , respectively , induced by outer membrane protein 29 from Actinobacillus actinomycetemcomitans ( A. actinomycetemcomitans ) in cultured human gingival epithelial cells ( HGEC ) .