passages.id: split_5_test_2492_passage
passages.type: progene_text
passages.text: Some amino acid substitutions at positions 86 and 90 ( helix C ) of hybrid IFN-alpha21a / alpha2c also affected the immunoreactivity of C-terminal - specific mAb , which recognize helix D , but did not influence the structure of C-terminus of IFN ( aa 151 - 165 ) .