passages.id: split_5_test_1646_passage
passages.type: progene_text
passages.text: The biguanide metformin had no effect on either enzyme , whereas the thiazolidinedione troglitazone inhibited 3betaHSDII ( K(I) = 25.4 +/- 5.1 microm ) and both activities of P450c17 ( K(I) for 17alpha-hydroxylase , 8.4 +/- 0.6 microm ; K(I) for 17,20-lyase , 5.3 +/- 0.7 microm ) .