passages.id: split_5_test_3170_passage
passages.type: progene_text
passages.text: RNAi silencing of APBA1 in H4 human neuroglioma cells stably transfected to express either full - length APP or APP-C99 increased APP C - terminal fragment levels and lowered Abeta levels in both cell lines by inhibiting gamma - secretase cleavage of APP .