passages.id: split_5_test_1356_passage
passages.type: progene_text
passages.text: Thus , under conditions that mimic an inflammatory or stressful microenvironment in vivo , BEC produce , secrete and respond to IL-6 , via upregulation and activation of the IL-6Ralpha ( gp80 ) / gp130 signaling system in an autocrine / paracrine manner .