passages.id: split_5_test_981_passage
passages.type: progene_text
passages.text: Expression of SHP2 in C2C12 mouse muscle cells attenuated the neuregulin - induced expression of an AChR epsilon - promoter reporter gene , whereas a catalytically inactive SHP2 mutant or a mutant lacking the N-terminal Src homology 2 ( SH2 ) domain enhanced reporter expression , suggesting that SHP2 negatively regulates the neuregulin signaling pathway .