passages.id: split_5_test_2536_passage
passages.type: progene_text
passages.text: We describe the functional consequences of three mis - sense mutations in the arylsulphatase A gene ( Asp - 335 - Val , Arg-370 - Trp and Arg-370-Gln ) , affecting an apparent intramolecular Asp-335 to Arg-370 salt bridge , and interpret the effects and clinical consequences on the basis of the three - dimensional structure of arylsulphatase A .