passages.id: split_5_test_329_passage
passages.type: progene_text
passages.text: Analyses of tyrosine residue - mutated PDGF receptors show that Src homology 2 domain - containing proteins including Src family kinases , phosphatidylinositol 3-kinase , the GTPase - activating protein of Ras , the Src homology 2 domain - containing phosphatase SHP-2 , phospholipase C-gamma , and Crk do not play a major role in mediating the PDGF - induced activation of p38 .