passages.id: split_5_test_2090_passage
passages.type: progene_text
passages.text: In both epithelial and fibroblastic cells , EMD ( 25 - 100 microgram / ml ) rapidly produced dose - dependent phosphorylation of the mitogen - activated protein kinase ( MAPK ) family : extracellular signal response kinase ( ERK ) , p38 - MAPK ( p38 - K ) , and c-Jun - terminal kinase / stress - activated protein kinase ( JNK ) .