passages.id: split_5_test_995_passage
passages.type: progene_text
passages.text: We report here studies on these processes in a human keratinocyte line ( HaCaT ) , which is a constitutive producer of tissue factor ( TF ) and responds to both FVIIa and FXa with elevation of cytosolic Ca(2+) , phosphorylation of extracellular signal - regulated kinase ( Erk ) 1/2 , p38 ( MAPK ) , and c-Jun N - terminal kinase , and up - regulation of transcription of the early growth response gene-1 ( egr-1 ) .