passages.id: split_5_test_3172_passage
passages.type: progene_text
passages.text: The notion of attenuating gamma - secretase cleavage of APP via the APP adaptor protein X11alpha is particularly attractive with regard to therapeutic potential given that side effects of gamma-secretase inhibition due to impaired proteolysis of other gamma - secretase substrates , e.g. Notch , might be avoided .