passages.id: split_4_validation_1350_passage
passages.type: progene_text
passages.text: Although overexpression of SHIP2 did not affect insulin - induced tyrosine phosphorylation of the insulin receptor beta - subunit and Shc , subsequent association of Shc with Grb2 was inhibited , possibly by competition between the SH2 domains of SHIP2 and Grb2 for the Shc phosphotyrosine .