09fd2ddb-dc6e-4d36-a556-29d98df9e758
title
Genetic variation at the  adiponectin  locus and risk of type 2 diabetes in women.
2a00d122-8888-46cf-ac9a-fa49e4f10220
abstract
Previous data suggesting that polymorphisms in the  adiponectin  gene were associated with insulin resistance or type 2 diabetes have been inconsistent. We assessed the relationship between five common haplotype-tagging single nucleotide polymorphisms (SNPs) in the  adiponectin  gene ( -11365C>G ,  -4034A>C ,  -3964A>G ,  +45T>G , and  +276G>T ), haplotypes defined by these SNPs, and the risk of type 2 diabetes by conducting a nested case-control study of 642 incident cases of type 2 diabetes and 995 matching control subjects in the Nurses' Health Study. Overall, we did not observe significant differences in genotype or allele frequencies for the five SNPs between the case and control subjects. After adjustment for diabetes risk factors, the  -4034 C/C  genotype was associated with a reduced risk of diabetes (odds ratio [OR] compared with the A/A genotype = 0.70, 95% CI 0.50-0.99, P = 0.04). In subgroup analyses, the +276 genotype was significantly associated with diabetes risk only among subjects with  peroxisome proliferator-activated receptor-gamma  ( PPAR gamma ) variant  12Ala  allele (OR comparing  +276 T  alleles with the G/G genotype = 1.69, 1.04-2.75, P = 0.035) or among obese subjects (1.46, 1.03-2.08, P = 0.03). These data suggest a potential interaction between the  adiponectin  genotype and  PPAR gamma  genotype or obesity, but these analyses should be considered exploratory and require further investigation in larger studies.