9a7fc193-e296-4778-baf1-cc37922b3f1f
title
Toll-like receptor 2 Arg677Trp  polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.
e82af0c8-a9cb-46df-9a6f-7f3a2c90bd9e
abstract
Toll-like receptor 2 (TLR2)  is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2  Arg677Trp  polymorphism  (C2029T nucleotide substitution)  in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.