4151fc43-4186-4c8d-8ed6-d1c8400e28dd
title
Association of  NQO1  polymorphism with spontaneous breast cancer in two independent populations.
c738b86a-b86b-4767-94b3-a67b71ddd815
abstract
Eight different single-nucleotide polymorphisms (SNPs) in six different genes were investigated for possible association with breast cancer. We used a case-control study design in two Caucasian populations, one from Tyrol, Austria, and the other from Prague, Czech Republic. Two SNPs showed an association with breast cancer:  R72P  in TP53  and  P187S  in  NQO1 . Six SNPs,  Q356R  and  P871L  in  BRCA1 ,  N372H  in  BRCA2 ,  C112R (E4)  and  R158C (E2)  in  ApoE  and  C825T  in  GNB3 , did not show any sign of association. The  P187S  polymorphism in  NQO1  was associated with breast cancer in both populations from Tyrol and Prague with a higher risk for carriers of the  187S  allele. Combining the results of the two populations, we observed a highly significant difference (P=0.0004) of genotype and allele frequencies (odds ratio (OR)=1.46; 95% confidence interval (CI) 1.16-1.85; P=0.001) and of the homozygote ratio (OR=3.8; 95% CI 1.73-8.34; P=0.0001). Combining the two 'candidate' SNPs ( P187S  and  R72P ) revealed an increased risk for breast cancer of double heterozygotes ( P187S / R72P ) of the  NQO1  and  TP53  genes (OR=1.88; 95% CI 1.13-3.15; P=0.011), suggesting a possible interaction of these two loci.