78fc68cc-0306-4985-b865-2e1a9f5e39b2
title
Association of  TAP2  gene polymorphisms in Chinese patients with rheumatoid arthritis.
0369aa6c-b8ac-4e92-bde3-0cbbb9b33511
abstract
The aim of this study was to investigate the association between the polymorphism of transporters associated with antigen processing (  TAP1 / TAP2 ) genes and rheumatoid arthritis in Chinese patients. A total of 100 RA patients and 99 healthy control subjects were enrolled. Analyses with polymerase chain reaction (PCR) based restrictions were used to identify the polymorphisms of the  TAP1  and  TAP2  genes, which were mapped on chromosome 6. There was a significant difference in the distribution of the  TAP2  gene codon 565 polymorphism frequency between the RA patients and healthy control subjects ( p<0.001). The odds ratio for the risk of the 'A' allele in RA patients was 1.60 (95% CI: 0.82-2.92). No statistical associations in the distribution of the  TAP1  gene polymorphism frequency were found between RA patients and controls. There were some physical links found between  TAP1 / TAP2  gene polymorphism loci. However, there was no linkage observed from  TAP1 / TAP2  gene polymorphisms and  HLA-DRB1*04  between RA patients and healthy controls. We concluded that the  TAP2  gene codon  565 'A'  allele was associated with RA in Chinese patients in Taiwan. Individuals possessing the 'A' allele had a higher incidence of RA. A lack of association of  TAP1  gene polymorphisms between RA patients and healthy individuals was noted. The results of this study provide genetic evidence that  TAP2  gene codon 565 polymorphism may play a role in RA.