5719c533-8dcb-4f32-aa98-b8e3139997eb
title
Polymorphisms in the  interleukin-20  gene: relationships to plaque-type psoriasis.
89ddb893-cb6a-45dc-8861-ef44755d3bf0
abstract
We analyzed the frequency of single-nucleotide polymorphisms (SNPs) at positions -1053 ( rs 2981572 ), 1380 ( rs 2981573 ), 1462 ( rs 2232360 ), and 3978 ( rs 1518108 ) of the human  interleukin-20  ( IL-20 ) gene by tetraprimer ARMS-PCR method. A significant association between patients with psoriasis and the  G allele at position -1053  (P<0.05) was established. The pairwise linkage disequilibrium (LD) matrix showed that the nearly complete LD was present within the polymorphisms at positions -1053, 1380, and 1462 of the  IL-20  gene. We found that patients with plaque psoriasis had a higher frequency of the  HT3  GAA haplotype (P<0.01, OR 2.341, 95% CI: 1.346-4.074) compared to the control group. Likewise, the  HT3  GAA haplotype was associated with an increased risk of early-onset psoriasis (P<0.01, OR 2.305, 95% CI: 1.285-4.132), late onset of disease (P<0.01, OR 2.542, 95% CI: 1.266-5.102), familial psoriasis (P<0.02, OR 2.220, 95% CI: 1.249-3.945), and sporadic disease (P<0.01, OR 2.523, 95% CI: 1.390-4.580). Our data indicate that  IL-20  gene polymorphisms should have a role in determining susceptibility to plaque-type psoriasis. The possible role of the studied SNPs in the regulation of the expression of  IL-20  is unknown yet and needs further studies.