f8683426-8805-469e-aa9b-9990da521bdc
title
The  Arg753GLn  polymorphism of the human  toll-like receptor 2  gene in tuberculosis disease.
e6b65436-1e48-4e4b-9133-f1eb0a3bb835
abstract
Toll-like receptor 2 (TLR2) TLR2 ), a member of the Toll-like receptor family, plays an important role in recognition of, and subsequent immune response activation against, mycobacteria. The genetic polymorphism of  TLR2  ( arginine to glutamine substitution at residue 753  ( Arg753Gln )) has been associated with a negative influence on  TLR2  function, which may, in turn, determine the innate host response to mycobacteria. The aim of the present study was to investigate the  Arg753Gln  single nucleotide polymorphism of the  TLR2  gene in tuberculosis (TB) patients compared to healthy controls. A retrospective case/control study was carried out. The Arg753Gln polymorphism of the  TLR2  gene was studied in 151 TB patients compared to 116 ethnically and age-matched healthy control subjects. The  TLR2  polymorphism (adenine (A) allele) was observed in 17.9 and 7.7% of TB patients and controls, respectively. When the ratios of the three genotypes were compared between the two groups, the AA genotype was found to be more significantly associated with TB. Allele frequencies for guanine (G) and A were found to be 0.95 and 0.05 in the control group and 0.86 and 0.14 in the TB patient group, respectively. The risk of developing TB disease was increased 6.04- and 1.60-fold for carriers of the AA and GA genotypes, respectively. In conclusion, the present data suggest that the  arginine to glutamine substitution at residue 753  polymorphism of the Toll-like receptor 2 gene influences the risk of developing tuberculosis.