6e7866bc-4ec0-4536-943c-f7d1a5fe251f
title
No association between the  insulin degrading enzyme  gene and Alzheimer's disease in a Japanese population.
2f7da9c6-a9c0-4785-9b90-19c8f84f472b
abstract
Susceptibility to Alzheimer's disease (AD) is thought to be regulated by multiple genetic factors. Recently, three independent studies have reported that loci on chromosome 10q are linked with AD, and the  insulin degrading enzyme  ( IDE ; MIM 146680) gene located on chromosome 10q23-q25;  IDE  is located close to the maker D10S583, which exhibits a maximum LOD score for late-onset AD. We examined seven polymorphisms in the  IDE  gene, the marker D10S583 in the 5' flanking region, and SNPs in introns 1, 3, 11, 20, 21, and 22 ( rs#1999764 ,  1855915 ,  1970244 ,  538469 ,  551266 , and  489517 , respectively). Four SNPs in introns 3, 11, 20, and 22 did not exhibit any polymorphisms in the Japanese population that was studied. D10S583 and two SNPs in introns 1 and 21 did not exhibit a significant association with early- or late-onset AD. In addition, no associations were observed for subgroups of AD grouped according to  APOE  status. The present study indicates that the  IDE  gene polymorphisms do not confer susceptibility to early- or late-onset AD at least in a Japanese population.