sentences.id: IEPA.d50.s127
sentences.origID: 68
sentences.text: Insulin secretion is regulated by changes in blood glucose, as well as by peptides from the gastrointestinal tract and neurotransmitters that activate the pancreatic islet adenylyl cyclase (e.g., glucagon-like peptide-1) and phospholipase C (PLC) (e.g., acetylcholine) signaling pathways to further potentiate glucose-induced insulin secretion
sentences.id: IEPA.d50.s127.e0
sentences.origID: 153
sentences.text: Insulin
sentences.id: IEPA.d50.s127.e1
sentences.origID: 154
sentences.text: phospholipase C
sentences.id: IEPA.d50.s127.e2
sentences.origID: 155
sentences.text: insulin
sentences.id: IEPA.d50.s127.i0
sentences.e1: IEPA.d50.s127.e1
sentences.e2: IEPA.d50.s127.e2
sentences.type: PPI
sentences.id: IEPA.d50.s128
sentences.origID: 69
sentences.text: However, leptin did constrain the enhanced PLC-mediated insulin secretion characteristic of islets from ob/ob mice, without influencing release from islets of lean mice
sentences.id: IEPA.d50.s128.e0
sentences.origID: 156
sentences.text: PLC
sentences.id: IEPA.d50.s128.e1
sentences.origID: 157
sentences.text: insulin
sentences.id: IEPA.d50.s128.i0
sentences.e1: IEPA.d50.s128.e0
sentences.e2: IEPA.d50.s128.e1
sentences.type: PPI
sentences.id: IEPA.d50.s129
sentences.origID: 70
sentences.text: A specific enhancement in PLC-mediated insulin secretion is the earliest reported developmental alteration in insulin secretion from islets of ob/ob mice, and thus a logical target for leptin action
sentences.id: IEPA.d50.s129.e0
sentences.origID: 158
sentences.text: PLC
sentences.id: IEPA.d50.s129.e1
sentences.origID: 159
sentences.text: insulin
sentences.id: IEPA.d50.s129.e2
sentences.origID: 160
sentences.text: insulin
sentences.id: IEPA.d50.s129.i0
sentences.e1: IEPA.d50.s129.e0
sentences.e2: IEPA.d50.s129.e1
sentences.type: PPI
sentences.id: IEPA.d50.s130
sentences.origID: 71
sentences.text: This action of leptin on PLC-mediated insulin secretion was dose-dependent, rapid-onset (i.e., within 3 min), and reversible
sentences.id: IEPA.d50.s130.e0
sentences.origID: 161
sentences.text: PLC
sentences.id: IEPA.d50.s130.e1
sentences.origID: 162
sentences.text: insulin
sentences.id: IEPA.d50.s130.i0
sentences.e1: IEPA.d50.s130.e0
sentences.e2: IEPA.d50.s130.e1
sentences.type: PPI
sentences.id: IEPA.d50.s131
sentences.origID: 72
sentences.text: Leptin was equally effective in constraining the enhanced insulin release from islets of ob/ob mice caused by protein kinase C (PKC) activation, a downstream mediator of the PLC signal pathway
sentences.id: IEPA.d50.s131.e0
sentences.origID: 163
sentences.text: insulin
sentences.id: IEPA.d50.s131.e1
sentences.origID: 164
sentences.text: PLC
sentences.id: IEPA.d50.s132
sentences.origID: 73
sentences.text: One function of leptin in control of body composition is thus to target a PKC-regulated component of the PLC-PKC signaling system within islets to prevent hypersecretion of insulin
sentences.id: IEPA.d50.s132.e0
sentences.origID: 165
sentences.text: PLC
sentences.id: IEPA.d50.s132.e1
sentences.origID: 166
sentences.text: insulin