sentences.id: IEPA.d56.s143
sentences.origID: 59
sentences.text: Interleukin-1 beta inhibits phospholipase C and insulin secretion at sites apart from KATP channel
sentences.id: IEPA.d56.s143.e0
sentences.origID: 133
sentences.text: phospholipase C
sentences.id: IEPA.d56.s143.e1
sentences.origID: 134
sentences.text: insulin
sentences.id: IEPA.d56.s144
sentences.origID: 60
sentences.text: Surprisingly, however, when islets were depolarized directly using either of two agonists, glyburide (which does not act via generation of purine nucleotides) or 40 mM K+ (which acts distal to KATP channel), PLC and insulin secretion were again obliterated by IL-1 beta
sentences.id: IEPA.d56.s144.e0
sentences.origID: 135
sentences.text: PLC
sentences.id: IEPA.d56.s144.e1
sentences.origID: 136
sentences.text: insulin
sentences.id: IEPA.d56.s145
sentences.origID: 61
sentences.text: These data (together with the finding that IL-1 beta inhibited Ca(2+)-induced insulin release) suggest that, in addition to its effects on ATP synthesis and thereby on the KATP channel, IL-1 beta has at least two undescribed, distal effects to block both PLC as well as Ca(2+)-induced exocytosis
sentences.id: IEPA.d56.s145.e0
sentences.origID: 137
sentences.text: insulin
sentences.id: IEPA.d56.s145.e1
sentences.origID: 138
sentences.text: PLC