sentences.id: IEPA.d42.s103
sentences.origID: 85
sentences.text: Signal transduction in pancreatic beta-cells: Regulation of insulin secretion by information flow in the phospholipase C/Protein kinase C pathway
sentences.id: IEPA.d42.s103.e0
sentences.origID: 192
sentences.text: insulin
sentences.id: IEPA.d42.s103.e1
sentences.origID: 193
sentences.text: phospholipase C
sentences.id: IEPA.d42.s103.i0
sentences.e1: IEPA.d42.s103.e0
sentences.e2: IEPA.d42.s103.e1
sentences.type: PPI
sentences.id: IEPA.d42.s104
sentences.origID: 86
sentences.text: The physiologic regulation of glucose-induced insulin secretion is dependent upon the activation of information flow in the phospholipase C (PLC)/protein kinase C (PKC) signal transduction system
sentences.id: IEPA.d42.s104.e0
sentences.origID: 194
sentences.text: insulin
sentences.id: IEPA.d42.s104.e1
sentences.origID: 195
sentences.text: phospholipase C
sentences.id: IEPA.d42.s104.i0
sentences.e1: IEPA.d42.s104.e0
sentences.e2: IEPA.d42.s104.e1
sentences.type: PPI
sentences.id: IEPA.d42.s105
sentences.origID: 87
sentences.text: When rat islet are cultured for short periods, the content and activation of PLC in response to glucose decreases and this biochemical defect in signal transduction is paralleled by significant reductions in glucose-induced insulin secretion
sentences.id: IEPA.d42.s105.e0
sentences.origID: 196
sentences.text: PLC
sentences.id: IEPA.d42.s105.e1
sentences.origID: 197
sentences.text: insulin
sentences.id: IEPA.d42.s106
sentences.origID: 88
sentences.text: Biphasic insulin secretion can be evoked and time-dependent potentiation can be induced in mouse islets by carbachol, an agonist that activates an isozyme of PLC distinct from that activated by glucose
sentences.id: IEPA.d42.s106.e0
sentences.origID: 198
sentences.text: insulin
sentences.id: IEPA.d42.s106.e1
sentences.origID: 199
sentences.text: PLC
sentences.id: IEPA.d42.s106.i0
sentences.e1: IEPA.d42.s106.e0
sentences.e2: IEPA.d42.s106.e1
sentences.type: PPI
sentences.id: IEPA.d42.s107
sentences.origID: 89
sentences.text: When taken in their entirety, the experimental evidence suggests that the activation of PLC is an essential component in the physiologic regulation of insulin secretion and that disordered activation of the enzyme culminates in disordered insulin release
sentences.id: IEPA.d42.s107.e0
sentences.origID: 200
sentences.text: PLC
sentences.id: IEPA.d42.s107.e1
sentences.origID: 201
sentences.text: insulin
sentences.id: IEPA.d42.s107.e2
sentences.origID: 202
sentences.text: insulin
sentences.id: IEPA.d42.s107.i0
sentences.e1: IEPA.d42.s107.e0
sentences.e2: IEPA.d42.s107.e1
sentences.type: PPI