sentences.id: IEPA.d195.s469
sentences.origID: 132
sentences.text: Leptin Rapidly Inhibits Hypothalamic Neuropeptide Y Secretion and Stimulates Corticotropin-Releasing Hormone Secretion in Adrenalectomized Mice
sentences.id: IEPA.d195.s469.e0
sentences.origID: 295
sentences.text: Leptin
sentences.id: IEPA.d195.s469.e1
sentences.origID: 296
sentences.text: Neuropeptide Y
sentences.id: IEPA.d195.s469.i0
sentences.e1: IEPA.d195.s469.e0
sentences.e2: IEPA.d195.s469.e1
sentences.type: PPI
sentences.id: IEPA.d195.s470
sentences.origID: 133
sentences.text: Leptin may rapidly inhibit food intake by altering the secretion of hypothalamic neuropeptides such as neuropeptide Y (NPY), a stimulator of food intake, and/or corticotropin-releasing hormone (CRH), an inhibitor of food intake
sentences.id: IEPA.d195.s470.e0
sentences.origID: 297
sentences.text: Leptin
sentences.id: IEPA.d195.s470.e1
sentences.origID: 298
sentences.text: neuropeptide Y
sentences.id: IEPA.d195.s470.i0
sentences.e1: IEPA.d195.s470.e0
sentences.e2: IEPA.d195.s470.e1
sentences.type: PPI
sentences.id: IEPA.d195.s471
sentences.origID: 134
sentences.text: We measured concentrations of NPY and CRH in specific hypothalamic regions [i.e., arcuate nucleus (ARC), paraventricular nucleus (PVN), ventromedial nucleus and dorsomedial nucleus] of 7- to 8-wk-old lean and ob/ob mice at 1 or 3 h after intracerebroventricular leptin administration
sentences.id: IEPA.d195.s471.e0
sentences.origID: 299
sentences.text: NPY
sentences.id: IEPA.d195.s471.e1
sentences.origID: 300
sentences.text: leptin
sentences.id: IEPA.d195.s472
sentences.origID: 135
sentences.text: No rapid-onset effects of leptin on hypothalamic NPY or CRH concentrations were observed in intact mice
sentences.id: IEPA.d195.s472.e0
sentences.origID: 301
sentences.text: leptin
sentences.id: IEPA.d195.s472.e1
sentences.origID: 302
sentences.text: NPY
sentences.id: IEPA.d195.s473
sentences.origID: 136
sentences.text: The addition of leptin to hypothalamic preparations from intact mice also did not alter NPY or CRH secretion
sentences.id: IEPA.d195.s473.e0
sentences.origID: 303
sentences.text: leptin
sentences.id: IEPA.d195.s473.e1
sentences.origID: 304
sentences.text: NPY
sentences.id: IEPA.d195.s474
sentences.origID: 137
sentences.text: Within 20 min after exposure to leptin, NPY secretion from hypothalamic preparations obtained from adrenalectomized mice was lowered by 27% and CRH secretion was elevated by 51%
sentences.id: IEPA.d195.s474.e0
sentences.origID: 305
sentences.text: leptin
sentences.id: IEPA.d195.s474.e1
sentences.origID: 306
sentences.text: NPY
sentences.id: IEPA.d195.s474.i0
sentences.e1: IEPA.d195.s474.e0
sentences.e2: IEPA.d195.s474.e1
sentences.type: PPI
sentences.id: IEPA.d195.s475
sentences.origID: 138
sentences.text: The current study demonstrates that leptin rapidly influences the secretion of hypothalamic NPY and CRH and that these actions of leptin within the hypothalamus are restrained by the presence of endogenous corticosterone
sentences.id: IEPA.d195.s475.e0
sentences.origID: 307
sentences.text: leptin
sentences.id: IEPA.d195.s475.e1
sentences.origID: 308
sentences.text: NPY
sentences.id: IEPA.d195.s475.e2
sentences.origID: 309
sentences.text: leptin
sentences.id: IEPA.d195.s475.i0
sentences.e1: IEPA.d195.s475.e0
sentences.e2: IEPA.d195.s475.e1
sentences.type: PPI