sentences.id: IEPA.d145.s346
sentences.origID: 262
sentences.text: Aggregated beta amyloid peptide 1-40 decreases Ca2+- and cholinergic receptor-mediated phosphoinositide degradation by alteration of membrane and cytosolic phospholipase C in brain cortex
sentences.id: IEPA.d145.s346.e0
sentences.origID: 571
sentences.text: amyloid
sentences.id: IEPA.d145.s346.e1
sentences.origID: 572
sentences.text: phospholipase C
sentences.id: IEPA.d145.s346.i0
sentences.e1: IEPA.d145.s346.e0
sentences.e2: IEPA.d145.s346.e1
sentences.type: PPI
sentences.id: IEPA.d145.s347
sentences.origID: 263
sentences.text: The effects of full-length amyloid beta protein, A(beta) (1-40), on phosphoinositide-specific phospholipase C (PLC) were investigated in synaptic plasma membranes (SPM) and cytosol prepared from the cerebral cortex of adult rats
sentences.id: IEPA.d145.s347.e0
sentences.origID: 573
sentences.text: amyloid
sentences.id: IEPA.d145.s347.e1
sentences.origID: 574
sentences.text: phospholipase C
sentences.id: IEPA.d145.s348
sentences.origID: 264
sentences.text: Aggregated A(beta) also decreased significantly the level of diacylglycerol, the product of PLC
sentences.id: IEPA.d145.s348.e0
sentences.origID: 575
sentences.text: A(beta)
sentences.id: IEPA.d145.s348.e1
sentences.origID: 576
sentences.text: PLC
sentences.id: IEPA.d145.s349
sentences.origID: 265
sentences.text: This additionally supports the inhibitory effect of A(beta) on membrane-bound and cytosolic PLC
sentences.id: IEPA.d145.s349.e0
sentences.origID: 577
sentences.text: A(beta)
sentences.id: IEPA.d145.s349.e1
sentences.origID: 578
sentences.text: PLC
sentences.id: IEPA.d145.s349.i0
sentences.e1: IEPA.d145.s349.e0
sentences.e2: IEPA.d145.s349.e1
sentences.type: PPI
sentences.id: IEPA.d145.s350
sentences.origID: 266
sentences.text: Moreover, A(beta) (1-40) significantly decreased the basal activity of the PIP2-PLC in SPM and the enzyme activity regulated through cholinergic receptors
sentences.id: IEPA.d145.s350.e0
sentences.origID: 579
sentences.text: A(beta) (1-40)
sentences.id: IEPA.d145.s350.e1
sentences.origID: 580
sentences.text: PIP2-PLC
sentences.id: IEPA.d145.s350.i0
sentences.e1: IEPA.d145.s350.e0
sentences.e2: IEPA.d145.s350.e1
sentences.type: PPI