sentences.id: IEPA.d109.s256
sentences.origID: 336
sentences.text: Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between messenger ribonucleic acid and protein expression
sentences.id: IEPA.d109.s256.e0
sentences.origID: 755
sentences.text: leptin
sentences.id: IEPA.d109.s256.e1
sentences.origID: 756
sentences.text: uncoupling protein
sentences.id: IEPA.d109.s256.i0
sentences.e1: IEPA.d109.s256.e0
sentences.e2: IEPA.d109.s256.e1
sentences.type: PPI
sentences.id: IEPA.d109.s257
sentences.origID: 337
sentences.text: In this study, we examined the effects of fasting for 2 days and exogenous s.c. leptin, 200 microg every 8 h for 2 days, on the regulation of uncoupling protein (UCP) subtypes in brown adipose tissue (BAT) and gastrocnemius muscle
sentences.id: IEPA.d109.s257.e0
sentences.origID: 757
sentences.text: leptin
sentences.id: IEPA.d109.s257.e1
sentences.origID: 758
sentences.text: uncoupling protein
sentences.id: IEPA.d109.s258
sentences.origID: 338
sentences.text: Leptin, compared with vehicle, did not alter BAT UCP-1 or UCP-3 mRNA or protein expression when administered to normal ad libitum fed rats
sentences.id: IEPA.d109.s258.e0
sentences.origID: 759
sentences.text: Leptin
sentences.id: IEPA.d109.s258.e1
sentences.origID: 760
sentences.text: UCP-1
sentences.id: IEPA.d109.s258.e2
sentences.origID: 761
sentences.text: UCP-3
sentences.id: IEPA.d109.s259
sentences.origID: 339
sentences.text: Fasting significantly decreased BAT UCP-1 and UCP-3 mRNA expression, to 31% and 30% of ad libitum fed controls, respectively, effects which were prevented by administration of leptin to fasted rats
sentences.id: IEPA.d109.s259.e0
sentences.origID: 762
sentences.text: UCP-1
sentences.id: IEPA.d109.s259.e1
sentences.origID: 763
sentences.text: UCP-3
sentences.id: IEPA.d109.s259.e2
sentences.origID: 764
sentences.text: leptin
sentences.id: IEPA.d109.s259.i0
sentences.e1: IEPA.d109.s259.e0
sentences.e2: IEPA.d109.s259.e2
sentences.type: PPI
sentences.id: IEPA.d109.s259.i1
sentences.e1: IEPA.d109.s259.e1
sentences.e2: IEPA.d109.s259.e2
sentences.type: PPI
sentences.id: IEPA.d109.s260
sentences.origID: 340
sentences.text: Fasting also significantly decreased BAT UCP-1 protein expression, to 67% of control; however, that effect was not prevented by leptin treatment
sentences.id: IEPA.d109.s260.e0
sentences.origID: 765
sentences.text: UCP-1
sentences.id: IEPA.d109.s260.e1
sentences.origID: 766
sentences.text: leptin
sentences.id: IEPA.d109.s261
sentences.origID: 341
sentences.text: Fasting, with or without leptin administration, did not affect BAT UCP-2 mRNA; however, leptin administration to ad libitum fed rats significantly increased BAT UCP-2 mRNA, to 138% of control
sentences.id: IEPA.d109.s261.e0
sentences.origID: 767
sentences.text: leptin
sentences.id: IEPA.d109.s261.e1
sentences.origID: 768
sentences.text: UCP-2
sentences.id: IEPA.d109.s261.e2
sentences.origID: 769
sentences.text: leptin
sentences.id: IEPA.d109.s261.e3
sentences.origID: 770
sentences.text: UCP-2
sentences.id: IEPA.d109.s261.i0
sentences.e1: IEPA.d109.s261.e2
sentences.e2: IEPA.d109.s261.e3
sentences.type: PPI
sentences.id: IEPA.d109.s262
sentences.origID: 342
sentences.text: Fasting significantly enhanced gastrocnemius muscle UCP-3 mRNA (411% of control) and protein expression (168% of control), whereas leptin administration to fasted rats did not alter either of these effects
sentences.id: IEPA.d109.s262.e0
sentences.origID: 771
sentences.text: UCP-3
sentences.id: IEPA.d109.s262.e1
sentences.origID: 772
sentences.text: leptin
sentences.id: IEPA.d109.s263
sentences.origID: 343
sentences.text: In summary, UCP subtype mRNA and protein are regulated in tissue- and subtype-specific fashion by leptin and food restriction
sentences.id: IEPA.d109.s263.e0
sentences.origID: 773
sentences.text: UCP
sentences.id: IEPA.d109.s263.e1
sentences.origID: 774
sentences.text: leptin
sentences.id: IEPA.d109.s263.i0
sentences.e1: IEPA.d109.s263.e0
sentences.e2: IEPA.d109.s263.e1
sentences.type: PPI