sentences.id: IEPA.d173.s419
sentences.origID: 7
sentences.text: We have established that the recovery of secreted N1 is increased by the protein kinase C agonists PDBu and PMA in a time- and dose-dependent manner in both cell lines
sentences.id: IEPA.d173.s419.e0
sentences.origID: 14
sentences.text: N1
sentences.id: IEPA.d173.s419.e1
sentences.origID: 15
sentences.text: protein kinase C
sentences.id: IEPA.d173.s420
sentences.origID: 8
sentences.text: In contrast, secretion of N1 remains unaffected by the inactive PDBu analog alphaPDD and by the protein kinase A effectors dibutyryl cAMP and forskolin
sentences.id: IEPA.d173.s420.e0
sentences.origID: 16
sentences.text: N1
sentences.id: IEPA.d173.s420.e1
sentences.origID: 17
sentences.text: protein kinase A
sentences.id: IEPA.d173.s421
sentences.origID: 9
sentences.text: Overall, our data indicate that the normal processing of PrP(c) is up-regulated by protein kinase C but not protein kinase A in human cells and murine neurons
sentences.id: IEPA.d173.s421.e0
sentences.origID: 18
sentences.text: PrP(c)
sentences.id: IEPA.d173.s421.e1
sentences.origID: 19
sentences.text: protein kinase C
sentences.id: IEPA.d173.s421.e2
sentences.origID: 20
sentences.text: protein kinase A
sentences.id: IEPA.d173.s421.i0
sentences.e1: IEPA.d173.s421.e0
sentences.e2: IEPA.d173.s421.e1
sentences.type: PPI