sentences.id: IEPA.d122.s290
sentences.origID: 327
sentences.text: Effects of intravenously infused leptin on insulin sensitivity and on the expression of uncoupling proteins in brown adipose tissue
sentences.id: IEPA.d122.s290.e0
sentences.origID: 731
sentences.text: leptin
sentences.id: IEPA.d122.s290.e1
sentences.origID: 732
sentences.text: uncoupling proteins
sentences.id: IEPA.d122.s290.i0
sentences.e1: IEPA.d122.s290.e0
sentences.e2: IEPA.d122.s290.e1
sentences.type: PPI
sentences.id: IEPA.d122.s291
sentences.origID: 328
sentences.text: Centrally administered leptin has been shown to increase insulin-stimulated glucose utilization and to favor the expression of uncoupling proteins (UCPs)
sentences.id: IEPA.d122.s291.e0
sentences.origID: 733
sentences.text: leptin
sentences.id: IEPA.d122.s291.e1
sentences.origID: 734
sentences.text: uncoupling proteins
sentences.id: IEPA.d122.s291.i0
sentences.e1: IEPA.d122.s291.e0
sentences.e2: IEPA.d122.s291.e1
sentences.type: PPI
sentences.id: IEPA.d122.s292
sentences.origID: 329
sentences.text: To study if leptin also has direct peripherally mediated effects on these processes, this hormone (1 mg/day) or its vehicle was infused i.v. for 4 days to lean rats and insulin-stimulated glucose utilization in skeletal muscle and adipose tissue as well as the expression of UCP messenger RNAs (mRNAs) in brown adipose tissue were measured
sentences.id: IEPA.d122.s292.e0
sentences.origID: 735
sentences.text: leptin
sentences.id: IEPA.d122.s292.e1
sentences.origID: 736
sentences.text: UCP
sentences.id: IEPA.d122.s293
sentences.origID: 330
sentences.text: I.v. leptin infusion also favored the expression of UCPs in brown adipose tissue, either by increasing their expression or preventing the fall occurring during the pair-feeding regimen.
sentences.id: IEPA.d122.s293.e0
sentences.origID: 737
sentences.text: leptin
sentences.id: IEPA.d122.s293.e1
sentences.origID: 738
sentences.text: UCPs
sentences.id: IEPA.d122.s293.i0
sentences.e1: IEPA.d122.s293.e0
sentences.e2: IEPA.d122.s293.e1
sentences.type: PPI
sentences.id: IEPA.d122.s294
sentences.origID: 331
sentences.text: Relative UCP expression levels were 100, 104, and 33 for UCP1, 100, 191, and 125 for UCP2 and 100, 107, and 29 for UCP3 in ad libitum fed control rats, in leptin-treated rats and in pair-fed control rats, respectively
sentences.id: IEPA.d122.s294.e0
sentences.origID: 739
sentences.text: UCP
sentences.id: IEPA.d122.s294.e1
sentences.origID: 740
sentences.text: UCP1
sentences.id: IEPA.d122.s294.e2
sentences.origID: 741
sentences.text: UCP2
sentences.id: IEPA.d122.s294.e3
sentences.origID: 742
sentences.text: UCP3
sentences.id: IEPA.d122.s294.e4
sentences.origID: 743
sentences.text: leptin
sentences.id: IEPA.d122.s295
sentences.origID: 332
sentences.text: These results suggest that the overall effect of leptin on glucose utilization and on the expression of UCPs may be mediated through central mechanism
sentences.id: IEPA.d122.s295.e0
sentences.origID: 744
sentences.text: leptin
sentences.id: IEPA.d122.s295.e1
sentences.origID: 745
sentences.text: UCPs
sentences.id: IEPA.d122.s295.i0
sentences.e1: IEPA.d122.s295.e0
sentences.e2: IEPA.d122.s295.e1
sentences.type: PPI