sentences.id: IEPA.d141.s338
sentences.origID: 29
sentences.text: Tolbutamide and diazoxide modulate phospholipase C-linked Ca(2+) signaling and insulin secretion in beta-cells
sentences.id: IEPA.d141.s338.e0
sentences.origID: 69
sentences.text: phospholipase C
sentences.id: IEPA.d141.s338.e1
sentences.origID: 70
sentences.text: insulin
sentences.id: IEPA.d141.s338.i0
sentences.e1: IEPA.d141.s338.e0
sentences.e2: IEPA.d141.s338.e1
sentences.type: PPI
sentences.id: IEPA.d141.s339
sentences.origID: 30
sentences.text: We examined whether tolbutamide and diazoxide, which close or open ATP-sensitive K(+) channels (K(ATP) channels), respectively, interact with PLC-linked Ca(2+) signals in HIT-T15 and mouse beta-cells and with PLC-linked insulin secretion from HIT-T15 cells
sentences.id: IEPA.d141.s339.e0
sentences.origID: 71
sentences.text: PLC
sentences.id: IEPA.d141.s339.e1
sentences.origID: 72
sentences.text: PLC
sentences.id: IEPA.d141.s339.e2
sentences.origID: 73
sentences.text: insulin
sentences.id: IEPA.d141.s339.i0
sentences.e1: IEPA.d141.s339.e1
sentences.e2: IEPA.d141.s339.e2
sentences.type: PPI
sentences.id: IEPA.d141.s340
sentences.origID: 31
sentences.text: Thus tolbutamide and diazoxide regulate both PLC-linked Ca(2+) signaling and insulin secretion from pancreatic beta-cells by modulating K(ATP) channels, thereby determining voltage-sensitive Ca(2+) influx
sentences.id: IEPA.d141.s340.e0
sentences.origID: 74
sentences.text: PLC
sentences.id: IEPA.d141.s340.e1
sentences.origID: 75
sentences.text: insulin
sentences.id: IEPA.d141.s340.i0
sentences.e1: IEPA.d141.s340.e0
sentences.e2: IEPA.d141.s340.e1
sentences.type: PPI