sentences.id: IEPA.d129.s307
sentences.origID: 320
sentences.text: Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats
sentences.id: IEPA.d129.s307.e0
sentences.origID: 709
sentences.text: leptin
sentences.id: IEPA.d129.s307.e1
sentences.origID: 710
sentences.text: uncoupling protein
sentences.id: IEPA.d129.s308
sentences.origID: 321
sentences.text: To further investigate neural effects on leptin and uncoupling proteins (UCPs), we studied in vivo perturbations intended to block adrenergic input to peripheral tissues
sentences.id: IEPA.d129.s308.e0
sentences.origID: 711
sentences.text: leptin
sentences.id: IEPA.d129.s308.e1
sentences.origID: 712
sentences.text: uncoupling proteins
sentences.id: IEPA.d129.s309
sentences.origID: 322
sentences.text: We examined plasma leptin, leptin mRNA, and adipose and muscle UCP subtype mRNA in rats treated with alpha-methyl-p-tyrosine methyl ester (AMPT-ME), which inhibits catecholamine synthesis and 6-hydroxydopamine (6HDA), which is toxic to catecholinergic nerve terminals but, unlike AMPT-ME, does not enter the central nervous system
sentences.id: IEPA.d129.s309.e0
sentences.origID: 713
sentences.text: leptin
sentences.id: IEPA.d129.s309.e1
sentences.origID: 714
sentences.text: leptin
sentences.id: IEPA.d129.s309.e2
sentences.origID: 715
sentences.text: UCP
sentences.id: IEPA.d129.s310
sentences.origID: 323
sentences.text: Intraperitoneal 6HDA, 100 mg/kg, as a single dose at 1800, increased plasma leptin approximately twofold after 18-20 h, increased IBAT (but not epididymal fat) leptin mRNA by two- to threefold, and decreased IBAT UCP-3 mRNA to 30-40% of control
sentences.id: IEPA.d129.s310.e0
sentences.origID: 716
sentences.text: leptin
sentences.id: IEPA.d129.s310.e1
sentences.origID: 717
sentences.text: leptin
sentences.id: IEPA.d129.s310.e2
sentences.origID: 718
sentences.text: UCP-3
sentences.id: IEPA.d129.s311
sentences.origID: 324
sentences.text: However, the in vivo modulation of leptin and UCPs appears complex and, beyond a causal effect of SNA per se, may depend on concurrent changes in plasma insulin, glucose, and circulatory hemodynamics
sentences.id: IEPA.d129.s311.e0
sentences.origID: 719
sentences.text: leptin
sentences.id: IEPA.d129.s311.e1
sentences.origID: 720
sentences.text: UCPs