sentences.id: IEPA.d190.s454
sentences.origID: 141
sentences.text: Leptin effects on pulsatile gonadotropin releasing hormone secretion from the adult rat hypothalamus and interaction with cocaine and amphetamine regulated transcript peptide and neuropeptide Y [In Process Citation]
sentences.id: IEPA.d190.s454.e0
sentences.origID: 314
sentences.text: Leptin
sentences.id: IEPA.d190.s454.e1
sentences.origID: 315
sentences.text: neuropeptide Y
sentences.id: IEPA.d190.s454.i0
sentences.e1: IEPA.d190.s454.e0
sentences.e2: IEPA.d190.s454.e1
sentences.type: PPI
sentences.id: IEPA.d190.s455
sentences.origID: 142
sentences.text: Leptin may act as a negative feedback signal to the hypothalamic control of appetite through suppression of neuropeptide Y (NPY) secretion and stimulation of cocaine and amphetamine regulated transcript (CART).
sentences.id: IEPA.d190.s455.e0
sentences.origID: 316
sentences.text: Leptin
sentences.id: IEPA.d190.s455.e1
sentences.origID: 317
sentences.text: neuropeptide Y
sentences.id: IEPA.d190.s455.i0
sentences.e1: IEPA.d190.s455.e0
sentences.e2: IEPA.d190.s455.e1
sentences.type: PPI
sentences.id: IEPA.d190.s456
sentences.origID: 143
sentences.text: We aimed at studying the effects of leptin, CART and NPY on the hypothalamic control of the pituitary-gonadal system.
sentences.id: IEPA.d190.s456.e0
sentences.origID: 318
sentences.text: leptin
sentences.id: IEPA.d190.s456.e1
sentences.origID: 319
sentences.text: NPY
sentences.id: IEPA.d190.s457
sentences.origID: 144
sentences.text: The increase in GnRH pulse amplitude caused by leptin was totally prevented by coincubation with an anti-CART antiserum whereas it was not affected by coincubation with the NPY Y5-receptor antagonist (10(-7) M).
sentences.id: IEPA.d190.s457.e0
sentences.origID: 320
sentences.text: leptin
sentences.id: IEPA.d190.s457.e1
sentences.origID: 321
sentences.text: NPY
sentences.id: IEPA.d190.s458
sentences.origID: 145
sentences.text: In conclusion, leptin and NPY show separate permissive effects on GnRH secretion in the adult rat hypothalamus.
sentences.id: IEPA.d190.s458.e0
sentences.origID: 322
sentences.text: leptin
sentences.id: IEPA.d190.s458.e1
sentences.origID: 323
sentences.text: NPY