sentences.id: IEPA.d40.s96
sentences.origID: 81
sentences.text: Roles of GTP and phospholipase C in the potentiation of Ca(2+)-induced insulin secretion by glucose in rat pancreatic islets
sentences.id: IEPA.d40.s96.e0
sentences.origID: 182
sentences.text: phospholipase C
sentences.id: IEPA.d40.s96.e1
sentences.origID: 183
sentences.text: insulin
sentences.id: IEPA.d40.s97
sentences.origID: 82
sentences.text: There was a 98% greater augmentation of insulin secretion by 16.7 mM glucose (in the presence of diazoxide and 40 mM K+) in primed islets; however, the ability of high glucose to augment PLC activity bore no relationship to the secretory response
sentences.id: IEPA.d40.s97.e0
sentences.origID: 184
sentences.text: insulin
sentences.id: IEPA.d40.s97.e1
sentences.origID: 185
sentences.text: PLC
sentences.id: IEPA.d40.s98
sentences.origID: 83
sentences.text: MPA markedly inhibited PLC in both conditions; however, insulin secretion was only inhibited (by 46%) in primed islets
sentences.id: IEPA.d40.s98.e0
sentences.origID: 186
sentences.text: PLC
sentences.id: IEPA.d40.s98.e1
sentences.origID: 187
sentences.text: insulin
sentences.id: IEPA.d40.s99
sentences.origID: 84
sentences.text: These data indicate that an adequate level of GTP is critical for glucose's potentiation of Ca(2+)-induced insulin secretion in primed islets but that PLC activation can clearly be dissociated from insulin secretion and therefore cannot be the major cause of glucose's augmentation of Ca(2+)-induced insulin secretion
sentences.id: IEPA.d40.s99.e0
sentences.origID: 188
sentences.text: insulin
sentences.id: IEPA.d40.s99.e1
sentences.origID: 189
sentences.text: PLC
sentences.id: IEPA.d40.s99.e2
sentences.origID: 190
sentences.text: insulin
sentences.id: IEPA.d40.s99.e3
sentences.origID: 191
sentences.text: insulin