sentences.id: IEPA.d80.s190
sentences.origID: 356
sentences.text: To explore the possible roles of the hypothalamic melanocortin system in leptin action, we examined the effects of intracerebroventricular (i.c.v.) injection of leptin with or without SHU9119, a potent antagonist of alpha-melanocyte stimulating hormone, on food intake, body weight, and mitochondrial uncoupling protein-1 (UCP-1) mRNA expression in the brown adipose tissue (BAT) in rats
sentences.id: IEPA.d80.s190.e0
sentences.origID: 813
sentences.text: leptin
sentences.id: IEPA.d80.s190.e1
sentences.origID: 814
sentences.text: leptin
sentences.id: IEPA.d80.s190.e2
sentences.origID: 815
sentences.text: uncoupling protein-1
sentences.id: IEPA.d80.s191
sentences.origID: 357
sentences.text: A single i.c.v. injection of leptin decreased cumulative food intake and body weight gain, and increased UCP-1 mRNA expression during 3 h at the onset of the dark phase
sentences.id: IEPA.d80.s191.e0
sentences.origID: 816
sentences.text: leptin
sentences.id: IEPA.d80.s191.e1
sentences.origID: 817
sentences.text: UCP-1
sentences.id: IEPA.d80.s191.i0
sentences.e1: IEPA.d80.s191.e0
sentences.e2: IEPA.d80.s191.e1
sentences.type: PPI
sentences.id: IEPA.d80.s192
sentences.origID: 358
sentences.text: Co-injection of SHU9119 also inhibited completely the leptin-induced increase in UCP-1 mRNA expression in the BAT
sentences.id: IEPA.d80.s192.e0
sentences.origID: 818
sentences.text: leptin
sentences.id: IEPA.d80.s192.e1
sentences.origID: 819
sentences.text: UCP-1
sentences.id: IEPA.d80.s192.i0
sentences.e1: IEPA.d80.s192.e0
sentences.e2: IEPA.d80.s192.e1
sentences.type: PPI