sentences.id: IEPA.d88.s207
sentences.origID: 351
sentences.text: To elucidate the pathophysiologic significance of UCP3 and UCP2 in the effect of TZDs on glucose metabolism and energy expenditure, we examined their basal mRNA levels in the WAT, brown adipose tissue (BAT), and skeletal muscle from Wistar fatty rats, a rat model of NIDDM and obesity with leptin receptor defect, and investigated expression of the genes encoding UCP3 and UCP2 in Wistar fatty rats and in Wistar lean rats with 2-week oral administration of 3 mg x kg(-1) x day(-1) pioglitazone, a TZD derivative
sentences.id: IEPA.d88.s207.e0
sentences.origID: 799
sentences.text: UCP3
sentences.id: IEPA.d88.s207.e1
sentences.origID: 800
sentences.text: UCP2
sentences.id: IEPA.d88.s207.e2
sentences.origID: 801
sentences.text: leptin
sentences.id: IEPA.d88.s207.e3
sentences.origID: 802
sentences.text: UCP3
sentences.id: IEPA.d88.s207.e4
sentences.origID: 803
sentences.text: UCP2
sentences.id: IEPA.d88.s208
sentences.origID: 352
sentences.text: These results clearly demonstrate that UCP3 gene expression is upregulated by TZDs in the WAT and BAT in Wistar fatty rats, an obese model with leptin receptor defect, and that adipose UCP3 gene expression is increased in response to TZDs in vitro
sentences.id: IEPA.d88.s208.e0
sentences.origID: 804
sentences.text: UCP3
sentences.id: IEPA.d88.s208.e1
sentences.origID: 805
sentences.text: leptin
sentences.id: IEPA.d88.s208.e2
sentences.origID: 806
sentences.text: UCP3