sentences.id: IEPA.d177.s426
sentences.origID: 160
sentences.text: As expected, in fusion of NPY alone (18 microg/day) augmented food intake (191.6% over the initial control, P < 0.05) and produced a 25.1% weight gain in conjunction with a 10-fold increase in serum leptin concentrations at the end of the 7-day period
sentences.id: IEPA.d177.s426.e0
sentences.origID: 354
sentences.text: NPY
sentences.id: IEPA.d177.s426.e1
sentences.origID: 355
sentences.text: leptin
sentences.id: IEPA.d177.s426.i0
sentences.e1: IEPA.d177.s426.e0
sentences.e2: IEPA.d177.s426.e1
sentences.type: PPI
sentences.id: IEPA.d177.s427
sentences.origID: 161
sentences.text: Interestingly, coinfusion of this regimen of NPY with the highly effective anorectic and body reducing effects of CNTF (5.0 microg/day) not only prevented the CNTF-induced anorexia and weight loss, but also normalized serum leptin concentrations and hypothalamic NPY gene expression
sentences.id: IEPA.d177.s427.e0
sentences.origID: 356
sentences.text: NPY
sentences.id: IEPA.d177.s427.e1
sentences.origID: 357
sentences.text: leptin
sentences.id: IEPA.d177.s427.e2
sentences.origID: 358
sentences.text: NPY
sentences.id: IEPA.d177.s427.i0
sentences.e1: IEPA.d177.s427.e0
sentences.e2: IEPA.d177.s427.e1
sentences.type: PPI
sentences.id: IEPA.d177.s428
sentences.origID: 162
sentences.text: These results demonstrate that chronic central infusion to produce a persistent elevation of the cytokine at pathophysiological levels (a situation that may normally manifest during infection, injury and inflammation) produced severe anorexia and weight loss in conjunction with reduction in both serum leptin concentrations and hypothalamic NPY gene expression
sentences.id: IEPA.d177.s428.e0
sentences.origID: 359
sentences.text: leptin
sentences.id: IEPA.d177.s428.e1
sentences.origID: 360
sentences.text: NPY