sentences.id: IEPA.d44.s112
sentences.origID: 383
sentences.text: Further, the oxytocin-induced activation of IK(sl) was effectively antagonized by 5 x 10(-8) mol/l U-73122 or 5 x 10(-6) mol/l 2-nitro-4-carboxyphenyl N,N-diphenylcarbamate (inhibitors of the cell membrane phospholipase C), as well as by intracellularly applied heparin (selective inhibitor of inositol-1,4,5-trisphosphate (IP3)-induced Ca2+ release channels)
sentences.id: IEPA.d44.s112.e0
sentences.origID: 874
sentences.text: oxytocin
sentences.id: IEPA.d44.s112.e1
sentences.origID: 875
sentences.text: inositol-1,4,5-trisphosphate
sentences.id: IEPA.d44.s113
sentences.origID: 384
sentences.text: The data obtained suggest (i) that selective oxytocin receptors are present on the membranes of guinea-pig antral smooth muscle cells, (ii) that the oxytocin-related relaxation may result from the activation of Ca(2+)-sensitive K+ conductivity via activation of IP3-induced release of Ca2+ from the submembrane located cisternae of the sarcoplasmic reticulum Ca2+ stores and (iii) in turn, this evokes a non-inactivating component of IK, hyperpolarizing the cell membrane
sentences.id: IEPA.d44.s113.e0
sentences.origID: 876
sentences.text: oxytocin
sentences.id: IEPA.d44.s113.e1
sentences.origID: 877
sentences.text: IP3