sentences.id: IEPA.d148.s359
sentences.origID: 313
sentences.text: In vivo effects of CGP-12177 on the expression of leptin and uncoupling protein genes in mouse brown and white adipose tissues
sentences.id: IEPA.d148.s359.e0
sentences.origID: 691
sentences.text: leptin
sentences.id: IEPA.d148.s359.e1
sentences.origID: 692
sentences.text: uncoupling protein
sentences.id: IEPA.d148.s360
sentences.origID: 314
sentences.text: OBJECTIVE: To assess the effect of chronic treatment with CGP-12177 a beta3-adrenergic receptor (AR) agonist with beta2/beta1-AR antagonist action, on the expression of the leptin gene and of genes coding for uncoupling proteins (ucp1, ucp2 and ucp3) in brown and white adipose tissues
sentences.id: IEPA.d148.s360.e0
sentences.origID: 693
sentences.text: leptin
sentences.id: IEPA.d148.s360.e1
sentences.origID: 694
sentences.text: uncoupling proteins
sentences.id: IEPA.d148.s361
sentences.origID: 315
sentences.text: CONCLUSION: The results reveal that simultaneous stimulation of the expression of certain ucp genes and the leptin gene can be achieved, and suggest that adrenergic regulation of the leptin gene and of genes of the ucp family in adipose tissues is the result of complex interactions between the different beta-AR pathways
sentences.id: IEPA.d148.s361.e0
sentences.origID: 695
sentences.text: ucp
sentences.id: IEPA.d148.s361.e1
sentences.origID: 696
sentences.text: leptin
sentences.id: IEPA.d148.s361.e2
sentences.origID: 697
sentences.text: leptin
sentences.id: IEPA.d148.s361.e3
sentences.origID: 698
sentences.text: ucp