sentences.id: IEPA.d162.s390
sentences.origID: 178
sentences.text: We previously reported that adiposity and serum leptin levels increase with age in male F-344xBN rats and that when physiological levels of serum leptin are manipulated by fasting, there is a corresponding reciprocal change in hypothalamic neuropeptide Y (NPY) mRNA in young rats, but there are no changes in older rats
sentences.id: IEPA.d162.s390.e0
sentences.origID: 387
sentences.text: leptin
sentences.id: IEPA.d162.s390.e1
sentences.origID: 388
sentences.text: leptin
sentences.id: IEPA.d162.s390.e2
sentences.origID: 389
sentences.text: neuropeptide Y
sentences.id: IEPA.d162.s391
sentences.origID: 179
sentences.text: These findings suggest that the regulation of hypothalamic NPY mRNA by leptin may be impaired with age
sentences.id: IEPA.d162.s391.e0
sentences.origID: 390
sentences.text: NPY
sentences.id: IEPA.d162.s391.e1
sentences.origID: 391
sentences.text: leptin
sentences.id: IEPA.d162.s391.i0
sentences.e1: IEPA.d162.s391.e0
sentences.e2: IEPA.d162.s391.e1
sentences.type: PPI
sentences.id: IEPA.d162.s392
sentences.origID: 180
sentences.text: We examined daily food consumption, body weight, whole-body oxygen consumption, serum leptin, and NPY mRNA in the hypothalamus
sentences.id: IEPA.d162.s392.e0
sentences.origID: 392
sentences.text: leptin
sentences.id: IEPA.d162.s392.e1
sentences.origID: 393
sentences.text: NPY
sentences.id: IEPA.d162.s393
sentences.origID: 181
sentences.text: Leptin infusion diminished hypothalamic NPY levels by nearly 50% compared with pair-fed young rats, whereas there were no changes in the hypothalamic NPY mRNA levels in senescent rats
sentences.id: IEPA.d162.s393.e0
sentences.origID: 394
sentences.text: Leptin
sentences.id: IEPA.d162.s393.e1
sentences.origID: 395
sentences.text: NPY
sentences.id: IEPA.d162.s393.e2
sentences.origID: 396
sentences.text: NPY
sentences.id: IEPA.d162.s393.i0
sentences.e1: IEPA.d162.s393.e0
sentences.e2: IEPA.d162.s393.e1
sentences.type: PPI
sentences.id: IEPA.d162.s394
sentences.origID: 182
sentences.text: These diminished responses to leptin were associated with and may be the result of an impaired suppression of hypothalamic NPY mRNA levels
sentences.id: IEPA.d162.s394.e0
sentences.origID: 397
sentences.text: leptin
sentences.id: IEPA.d162.s394.e1
sentences.origID: 398
sentences.text: NPY