text:  Bone Marrow_Vehicle 2_Topotecan [1346-04F_8M 96] Bone Marrow_5% Dextrose followed by Topotecan strain: Sprague-Dawley; Sex: Male; age: 8 weeks; tissue: Bone marrow; dose 1: 0 mg/kg; vehicle 1: 5% Dextrose in water; compound 2: Topotecan; dose 2: 4.7 mg/kg; vehicle 2: 0.9% NaCl; time: 24 hour; route: intravenous (IV)