text: Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.
  The nonsteroidal anti-inflammatory drugs flurbiprofen and ibuprofen were modified in an attempt to alter the kinetics of inhibitor binding by COX-1. Contrary to prior predictions, a halogen substituent is not sufficient to confer slow tight-binding behavior. Conversion of the carboxylate moiety of flurbiprofen to an ester or amide abolishes slow tight-binding behavior, regardless of halogenation state.
entities.id: T10 T1 T2 T3 T4 T5 T6 T7 T8 T9
entities.type: GENE-N CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL GENE-Y
entities.text: cyclooxygenase halogen carboxylate flurbiprofen ester amide flurbiprofen ibuprofen 2-aryl propionic acid COX-1