tokens: Results indicated that ( i ) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy ( p < 0.01 ) and positively correlated with the proportion of lymphocytes ( r = 0.6895 , p < 0.01 ) and negatively with the proportion of immature cells ( r = -0.568 , p < 0.01 ) contained in the pbmc preparations tested , ( ii ) constitutive mRNA levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other , but failed to relate to disease parameters , and ( iii ) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients .