tokens: The results indicated that concomitant treatment with gum Arabic and GM significantly increased creatinine and urea by about 183 and 239 % , respectively ( compared to 432 and 346 % , respectively , in rats treated with cellulose and GM ) , and decreased that of cortical GSH by 21 % ( compared to 27 % in the cellulose plus GM group ) The GM - induced proximal tubular necrosis appeared to be slightly less severe in rats given GM together with gum Arabic than in those given GM and cellulose .