tokens: The doses calculated to cause 50 % reversal of hyperalgesia ( ED50 ) were 7 . 54 ( 1 . 81 ) and 4 . 83 ( 1 . 54 ) in the carrageenan model and 44 . 18 ( 1 . 37 ) and 9 . 14 ( 1 . 24 ) in the STZ - induced neuropathy model for CNSB002 and morphine , respectively ( mg / kg ; mean , SEM ) .