tokens: We now show that : 1 ) CVZ has more than one binding site in a second , independent , B-cell line , IM-9 ; 2 ) the antiglucocorticoid RU 38486 is able to block both CVZ 's higher and lower affinity sites ; 3 ) all of CVZ 's binding sites are on a protein immunologically indistinguishable from the human GR ; and 4 ) freshly isolated clones of CVZ-resistant cells have lost all binding sites for CVZ .