tokens: Evolution of a case of chronic lymphocytic leukemia ( CLL ) into blast crisis was found to be characterized by three unusual features ( 1 ) the phenotype of the emerging blast cells was that of pre-plasmacytoid cells as shown by plasma cell morphology and an immunological phenotype corresponding partially with CLL- or intermediate B-cells , partially with plasma cells ( terminal transferase - , common acute lymphocytic leukemia antigen - , Ia+ , surface immunoglobulin heavy chains - , surface kappa light chains + , intracytoplasmic immunoglobulin A+ and G+ , BA-1+ , polyclonal gammaglobulin production ) ; ( 2 ) cytogenetic analysis of spontaneous metaphases revealed that in addition to the typical CLL abnormality , trisomy 12 , in all of the cells , an additional translocation between chromosomes 14 and 17 was present in 40 % with a presumptive breakpoint on chromosome 14 ( q12-3 ) never described before ( commonly q32 ) and ( 3 ) the progression of the disease was associated with a striking increase in the expression by the transformed cells of specific binding sites for estradiol ( E2 ) due to an actual increase in total cellular receptor proteins and not to a change in receptor affinity for E2 .