tokens: It was also found that though inhibition of phosphatidyl-inositol 3-kinase ( PI-3K ) by LY294002 in alpha ( IIb ) beta ( 3 ) ( + ) cells induced apoptosis and inhibited chemotaxis adhesion and the secretion of MMP-9 and VEGF , the inhibition of MAPK p42/44 ( by the MEK inhibitor U0126 ) had no effect on the survival , proliferation , and migration of these cells .