tokens: Allopregnanolone ( 3alpha - hydroxy - 5alpha - pregnan - 20 - one ) , pregnanolone ( 3alpha - hydroxy - 5beta - pregnan - 20 - one ) and ganaxolone ( a synthetic derivative of allopregnanolone 3alpha - hydroxy - 3beta - methyl - 5alpha - pregnan - 20 - one ) were tested for their ability to suppress the expression ( anticonvulsant effect ) and development ( antiepileptogenic effect ) of cocaine - kindled seizures in male , Swiss - Webster mice .