tokens: Adult male albino rats , treated with ISO ( 200 mg / kg , s . c . ) for 2 days at an interval of 24 h caused a significant ( P < 0 . 05 ) elevation of heart weight , serum marker enzymes , lipid peroxidation and Ca + 2 ATPase level whereas there was a significant ( P < 0 . 05 ) decrease in body weight , endogenous antioxidants , Na + / K + ATPase and Mg + 2 ATPase levels .