tokens: Although the energy - based DFT was not affected by isoproterenol ( from 6 . 1 + / - 1 . 5 to 6 . 0 + / - 1 . 7 J ) , it was decreased to 3 . 7 + / - 1 . 6 J in the third stage by infusion of E4031 and isoproterenol ( p < 0 . 01 vs . baseline and vs . isoproterenol ) .