tokens: Three RasV12 mutants ( S35 , G37 , and C40 ) which differ by their ability to bind to Ras effectors ( Raf , Ral - GEFs , and the p110 subunit of PI 3 - kinase , respectively ) were able to induce sustained NR cell proliferation , although none of these mutants was reported to transform NIH 3T3 cells .