tokens: Significantly , two proximal GATA - 1 - binding sites ( - 118 / - 113 and - 98 / - 93 ) and a region located within - 518 to - 315bp of the mouse ALAS2 promoter were essential for transcriptional activation during chemically induced differentiation of MEL cells , implying their importance in conferring erythroid specificity to the ALAS2 transcriptional activation .