tokens: Diltiazem decreased the total body clearance from 34 . 0 + / - 8 . 0 to 28 . 6 + / - 6 . 1 mL / min ( P less than . 01 ) , and prolonged the elimination half - life from 12 . 6 + / - 3 . 0 to 14 . 3 + / - 2 . 5 hours ( P less than . 01 ) of antipyrine without any changes in volume of distribution .