tokens: In patients , 750 mL of saline lowered DL ( CO ) ( - 8 % , P < 0 . 01 versus baseline ) , D ( M ) ( - 10 % , P < 0 . 01 versus baseline ) , aldosterone ( - 29 % , P < 0 . 01 versus baseline ) , renin ( - 52 % , P < 0 . 01 versus baseline ) , and hematocrit ( - 6 % , P < 0 . 05 versus baseline ) and increased V ( C ) ( 20 % , P < 0 . 01 versus baseline ) , without changing rap and wpp .