tokens: Reaction of aromatic / heterocyclic sulfonamides possessing free amino , imino or hydrazino moieties with 7 - chloro - 4 - chloromethylcoumarin afforded a series of N - [ ( 7 - chloro - 4 - coumarinyl ) - methyl ] - derivatives which showed effective inhibition of three carbonic anhydrase ( CA ) isozymes .