tokens: Candidate factors have been identified by the observation that changes in glucocorticoid induction parameters in CV - 1 cells could be reproduced by varying the cellular levels of coactivators [ transcriptional intermediary factor 2 ( TIF2 ) , steroid receptor coactivator 1 ( SRC - 1 ) , and amplified in breast cancer 1 ( AIB1 ) ] , comodulator [ CREB - binding protein ( CBP ) ] , or corepressor [ silencing mediator for retinoid and thyroid - hormone receptors ( SMRT ) ] without concomitant increases in GR .