tokens: Since 1985 the combination of chlorambucil ( 10 mg daily , initially for six weeks , then alternating fortnights for 12 weeks ) and interferon - alpha 2b ( Schering - Plough ; 2 x 10 ( 6 ) U / m2 three times weekly by subcutaneous injection for 18 weeks ) has been compared in a randomised trial with chlorambucil alone in previously untreated patients with stage III or IV follicular lymphoma .