passages.id: 1.0alpha7.train.518.sent
passages.type: sentence
passages.text:  Complicating such studies is the fact that, in many perinatal  rodents,  E2 is much less potent than DES as an  estrogen due to high serum concentrations of  alpha-fetoprotein (AFP), which binds  E2 but not DES with high affinity [ 17].  
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