passages.id: 1.0alpha7.train.907.sent
passages.type: sentence
passages.text: Taken together, these findings support a model in which binding of Hsp90 with Apaf-1: (i) induces a potential conformational change in Apaf-1 and (ii) inhibits cyt c/dATP-mediated oligomerization of Apaf-1, and thereby exerts a dominant-negative effect on the function of Apaf-1 to activate procaspase-9. 
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