passages.id: 1.0alpha7.train.923.sent
passages.type: sentence
passages.text: In the water-mediated  S1 binding mode of  APC-10950, the ether oxygen does not make hydrogen bonds (  Fig. 6b), whereas in the direct amidine-Asp189 hydrogen-bonded mode of  APC-11092, this oxygen receives a hydrogen bond from N 2His57 (  Fig. 6a).
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