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passages.type: sentence
passages.text: This fact suggests that, in addition to blocking the “adhesive sites” of desmosomal cadherins with anti-Dsg PV IgG, binding of pemphigus antibodies to KC initiates an intracellular signaling cascade that can lead to disassembly of other types of intercellular junctions comprised of classical cadherins, such as tight junctions, adherence junctions, and gap junctions, all of which can mediate keratinocyte cell-to-cell adhesion at low Ca2+ (51-53).
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