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passages.text: Based on a sequence comparison between IP4-sensitive and -insensitive isoforms (Figs. 3 and 4 A) and deletion or mutational analysis of synaptotagmin III (Figs. 4 and 5), we propose that the primitive form of synaptotagmin originally bound IP4 and that, during the diversification of synaptotagmin in vertebrates, some isoforms (III, V, and X) lost their IP4 binding activity as a consequence of several amino acid substitutions mainly in the C-terminal region of the C2B domain, but not in the putative IP4-binding site itself.
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