abstract: @entity1204 is a common @entity5 of the genital tract. In the present study, we examined the expression of @entity1 @entity624 ( @entity624 ) protein, @entity5986 ( @entity5986 ), 17alpha-hydroxylase/17,20-desmolase (P45017alpha) and aromatase (P450 arom) in @entity1204 cells to clarify the ability of these cells to produce @entity134 hormones. The results of RT-PCR analysis showed that @entity624 , @entity5986 and P45017alpha genes were expressed in @entity1204 cells. To examine the protein expression of @entity624 and @entity5986 , we performed Western blotting using extracts from @entity189 cells. @entity624 protein and @entity5986 were detected in both HHUA and HOUA-1 cells. The production of @entity3333 in HHUA cells increased 2.4-fold with transfection of a @entity624 expression vector and 4.3-fold with transfection of an F2 side-chain cleavage system. The RT-PCR product of @entity1816 dehydrogenase was present in @entity1204 cells. In @entity1204 cells, the production of @entity1420 also increased with over-expression of @entity624 and the F2 system. Results of @entity134 metabolic assays showed that @entity1204 cells produced not only @entity4418 but also @entity2671 . @entity1204 cells express enzymes that are associated with the production of @entity134 hormones. Locally produced @entity134 hormones may have effects on @entity5 proliferation and tumorigenesis.
  
entities_list.pseudoidentifier: @entity1204 @entity1 @entity624 @entity5986 @entity1420 @entity5 @entity3333 @entity1816 @entity189 @entity134 @entity4418 @entity2671
entities_list.identifier: ('MESH:D016889', 'Disease') ('9606', 'Species') ('6770', 'Gene') ('1583', 'Gene') ('MESH:D011374', 'Chemical') ('MESH:D009369', 'Disease') ('MESH:D011284', 'Chemical') ('CHEBI:36836', 'Chemical') ('MESH:D002277', 'Disease') ('CHEBI:35341', 'Chemical') ('MESH:D019326', 'Chemical') ('MESH:D000735', 'Chemical')
entities_list.synonyms: ['endometrial carcinoma', 'Endometrial carcinoma'] ['human'] ['steroidogenic acute regulatory', 'StAR'] ['P450 scc', 'P450 side-chain cleavage enzyme'] ['progesterone'] ['tumor', 'malignancy'] ['pregnenolone'] ['3beta-hydroxysteroid'] ['carcinoma'] ['steroid'] ['17alpha-hydroxyprogesterone'] ['androstenedione']