text: Primary hyperparathyroidism and the heart: cardiac abnormalities correlated to clinical and biochemical data.
  Comparing patients with primary hyperparathyroidism (PHP) to a normocalcemic control population, those with PHP have a higher incidence of cardiovascular disease and cardiac abnormalities. This study aimed at correlating cardiac findings (valvular and myocardial calcification, myocardial hypertrophy) with clinical data (age, sex, clinical manifestation, nephrolithiasis, nephrocalcinosis, hypertension, skeletal abnormalities, hypercalcemic syndrome) and biochemical data (serum calcium, serum phosphate, serum iPTH level, serum creatinine). A group of 132 consecutive patients with surgically verified PHP (94 women, 38 men; ages 15-86, mean age 57 +/- 16 years) were included in this study. Blood chemistry, clinical presentation, radiography, and echocardiography were carried out in all patients for univariate and multivariate analyses of all parameters. There was no statistical correlation between clinical symptoms, biochemical data, and cardiac calcific alterations. Typical skeletal manifestations (osteolysis/subperiostal resorption) and valvular calcifications were significantly correlated to left ventricular hypertrophy (p = 0.005). Cardiac abnormalities such as calcific myocardial deposits or mitral and aortic valvular calcifications do not correlate with laboratory findings and clinical presentation at the time of diagnosis. There was no biochemical or clinical variable that could predict the frequency or severity of valvular sclerosis or calcific deposits in the myocardium. However, PHP-related skeletal abnormalities and valvular calcification were predicting factors for left ventricular hypertrophy, a reversible cardiac manifestation of PHP. Myocardial hypertrophy is more often found with classic symptomatic PHP with osseous abnormalities.
  
entities.text: ['heart']
entities.type: Organ
entities.entity_id: PMID-7725754_T1
entities.text: ['cardiac']
entities.type: Organ
entities.entity_id: PMID-7725754_T2
entities.text: ['cardiovascular']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T3
entities.text: ['cardiac']
entities.type: Organ
entities.entity_id: PMID-7725754_T4
entities.text: ['cardiac']
entities.type: Organ
entities.entity_id: PMID-7725754_T5
entities.text: ['valvular']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T6
entities.text: ['myocardial']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T7
entities.text: ['myocardial']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T8
entities.text: ['skeletal']
entities.type: Anatomical_system
entities.entity_id: PMID-7725754_T9
entities.text: ['serum']
entities.type: Organism_substance
entities.entity_id: PMID-7725754_T10
entities.text: ['serum']
entities.type: Organism_substance
entities.entity_id: PMID-7725754_T11
entities.text: ['serum']
entities.type: Organism_substance
entities.entity_id: PMID-7725754_T12
entities.text: ['serum']
entities.type: Organism_substance
entities.entity_id: PMID-7725754_T13
entities.text: ['Blood']
entities.type: Organism_substance
entities.entity_id: PMID-7725754_T14
entities.text: ['cardiac']
entities.type: Organ
entities.entity_id: PMID-7725754_T15
entities.text: ['skeletal']
entities.type: Anatomical_system
entities.entity_id: PMID-7725754_T16
entities.text: ['valvular']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T17
entities.text: ['left ventricular']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T18
entities.text: ['Cardiac']
entities.type: Organ
entities.entity_id: PMID-7725754_T19
entities.text: ['myocardial']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T20
entities.text: ['mitral']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T21
entities.text: ['aortic valvular']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T22
entities.text: ['valvular']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T23
entities.text: ['myocardium']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T24
entities.text: ['skeletal']
entities.type: Anatomical_system
entities.entity_id: PMID-7725754_T25
entities.text: ['valvular']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T26
entities.text: ['left ventricular']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T27
entities.text: ['cardiac']
entities.type: Organ
entities.entity_id: PMID-7725754_T28
entities.text: ['Myocardial']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-7725754_T29
entities.text: ['osseous']
entities.type: Organ
entities.entity_id: PMID-7725754_T30