text: Methotrexate osteopathy in rheumatic disease.
  OBJECTIVE:
  To determine whether two adults with stress fractures receiving low weekly doses of methotrexate had methotrexate osteopathy.
  CASE REPORTS:
  Two adult patients developed features consistent with methotrexate osteopathy while receiving low weekly doses of methotrexate.
  METHODS:
  Iliac crest biopsy samples were taken and bone histomorphometry carried out.
  RESULTS:
  Symptoms resolved when the methotrexate was discontinued. Bone histology showed changes consistent with osteoblast inhibition by methotrexate.
  CONCLUSIONS:
  When given in low doses for prolonged periods, methotrexate may have adverse effects on bone, particularly in post-menopausal women.
  
entities.text: ['Iliac crest biopsy samples']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-8215620_T1
entities.text: ['bone']
entities.type: Tissue
entities.entity_id: PMID-8215620_T2
entities.text: ['Bone']
entities.type: Tissue
entities.entity_id: PMID-8215620_T3
entities.text: ['osteoblast']
entities.type: Cell
entities.entity_id: PMID-8215620_T4
entities.text: ['bone']
entities.type: Organ
entities.entity_id: PMID-8215620_T5